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Search of human proteins with 4504335
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
(1663 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 3324 0.0
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 3278 0.0
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 2611 0.0
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 231 4e-60
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 231 4e-60
gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens] 229 2e-59
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 226 1e-58
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 226 1e-58
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 226 2e-58
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 226 2e-58
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 218 5e-56
gi|148529025 pleckstrin homology domain containing, family G (wi... 199 1e-50
gi|193211603 pleckstrin homology domain containing, family G (wi... 178 4e-44
gi|193211598 pleckstrin homology domain containing, family G (wi... 178 4e-44
gi|193211596 pleckstrin homology domain containing, family G (wi... 178 4e-44
gi|193211594 pleckstrin homology domain containing, family G (wi... 178 4e-44
gi|55742734 pleckstrin homology domain containing, family G (wit... 178 4e-44
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 170 1e-41
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 134 1e-30
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 134 1e-30
gi|71274148 pleckstrin homology domain containing, family G (wit... 128 4e-29
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 112 3e-24
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 105 4e-22
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 104 8e-22
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 102 3e-21
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 97 2e-19
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 93 2e-18
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 90 2e-17
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 90 2e-17
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 87 1e-16
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 3324 bits (8618), Expect = 0.0
Identities = 1663/1663 (100%), Positives = 1663/1663 (100%)
Query: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF
Sbjct: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
Query: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP
Sbjct: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
Query: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH
Sbjct: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
Query: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA
Sbjct: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
Query: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH
Sbjct: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
Query: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN
Sbjct: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
Query: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF
Sbjct: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
Query: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD
Sbjct: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
Query: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV
Sbjct: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
Query: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA
Sbjct: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
Query: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL
Sbjct: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
Query: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE
Sbjct: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
Query: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE
Sbjct: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
Query: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT
Sbjct: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
Query: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK
Sbjct: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
Query: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ
Sbjct: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
Query: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE
Sbjct: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
Query: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI
Sbjct: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
Query: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK
Sbjct: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
Query: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE
Sbjct: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
Query: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR
Sbjct: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
Query: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL
Sbjct: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
Query: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL
Sbjct: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
Query: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD
Sbjct: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
Query: 1621 GSSQPDTISIASRTSQNTVDSDKDGNLVPRWHLGPGDPFSTYV 1663
GSSQPDTISIASRTSQNTVDSDKDGNLVPRWHLGPGDPFSTYV
Sbjct: 1621 GSSQPDTISIASRTSQNTVDSDKDGNLVPRWHLGPGDPFSTYV 1663
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 3278 bits (8499), Expect = 0.0
Identities = 1643/1643 (100%), Positives = 1643/1643 (100%)
Query: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF
Sbjct: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
Query: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP
Sbjct: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
Query: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH
Sbjct: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
Query: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA
Sbjct: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
Query: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH
Sbjct: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
Query: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN
Sbjct: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
Query: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF
Sbjct: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
Query: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD
Sbjct: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
Query: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV
Sbjct: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
Query: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA
Sbjct: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
Query: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL
Sbjct: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
Query: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE
Sbjct: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
Query: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE
Sbjct: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
Query: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT
Sbjct: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
Query: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK
Sbjct: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
Query: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ
Sbjct: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
Query: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE
Sbjct: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
Query: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI
Sbjct: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
Query: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK
Sbjct: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
Query: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE
Sbjct: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
Query: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR
Sbjct: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
Query: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL
Sbjct: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
Query: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL
Sbjct: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
Query: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD
Sbjct: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
Query: 1621 GSSQPDTISIASRTSQNTVDSDK 1643
GSSQPDTISIASRTSQNTVDSDK
Sbjct: 1621 GSSQPDTISIASRTSQNTVDSDK 1643
Score = 218 bits (554), Expect = 5e-56
Identities = 121/327 (37%), Positives = 200/327 (61%), Gaps = 11/327 (3%)
Query: 1273 EEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGN 1332
E+K K+ R + F++ EL+QTEK YV+DL +E ++ + + +P + K+ I+FGN
Sbjct: 1921 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE--KGVPEDMRGKDKIVFGN 1978
Query: 1333 IQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGT 1392
I +IYD+H + FL ELEK Q + + F+ K +YV YC+NKP S ++ E+
Sbjct: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
Query: 1393 FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD---GLEVMLSV 1449
+F+E++Q ++S +LIKP+QRITKYQLLLK+ L E+ E D +E+M V
Sbjct: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
Query: 1450 PKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD-PKSLIRKGRERHLFLFEISLVFS 1508
PK+ ND M++ L+GF+ L QG+L+ QD F V + + + +ER +FLFE ++FS
Sbjct: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFS 2157
Query: 1509 KEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETK 1568
+ ++ S Y++K + + L + E+V+ DPCKFAL + T + VL+A+N + +
Sbjct: 2158 ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET---SERVVLQAANADIQ 2214
Query: 1569 QEWIKNIREVIQERIIHLKGALKEPLQ 1595
Q W+++I +V++ + L AL+ P++
Sbjct: 2215 QAWVQDINQVLETQRDFL-NALQSPIE 2240
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 2611 bits (6767), Expect = 0.0
Identities = 1273/1626 (78%), Positives = 1464/1626 (90%), Gaps = 27/1626 (1%)
Query: 22 RGSFR-NDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTY 80
R FR ND +KA DVLPILKEKVA++SGGRDKRGGPILTFPARSNHDRIRQEDLR+L++Y
Sbjct: 51 RSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISY 110
Query: 81 LASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKT 140
LA +PSE+VCKRGFTVI+DMRGSKWD IKPLLK LQE+FP IHVALIIKPDNFWQKQ+T
Sbjct: 111 LACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRT 170
Query: 141 NFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHL 200
NFGSSKF FET+MVS+EGLTK+VDPSQLT EFDG L+YNHEEWIE+R++ E++ ++A H+
Sbjct: 171 NFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHM 230
Query: 201 LSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
LSRLE+LQ++LA+KE P D+EG+R +I+EH+QLKKKV+KAP+E+LD EGQ+LLQ I+ S+
Sbjct: 231 LSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSE 290
Query: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
F +N G+AD Q+L+PK++++LD+LHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE
Sbjct: 291 SFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 350
Query: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSE 380
KMFDWI+HNK LFL S+TEIG S+ +A++LQTQHNHFAMN MN YVNINRIMSVA+RL E
Sbjct: 351 KMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVE 410
Query: 381 AGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSE 440
+GHYASQQI+QI++QL+QEWK+FAAALDERST+L MS++FHQKAE+++S VD+WCK C E
Sbjct: 411 SGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGE 470
Query: 441 GGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANY 500
LPSE+QDLE AIHHHQ +YE +T AY+EVSQDGK+LLD LQRPL+PG+S+SLTA+ANY
Sbjct: 471 VDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANY 530
Query: 501 SKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 560
SKAVH VLDV+HEVLHHQR+LE+IWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL
Sbjct: 531 SKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 590
Query: 561 SKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAAR 620
SKHTGVGKSLHRARALQKRH+DFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIY+AA
Sbjct: 591 SKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAH 650
Query: 621 HLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELI 680
LE RIQDFVRRVEQRK+LLDMSVSFHTH KELWTW+E+LQKE+L+DV A+SV+AVQ+LI
Sbjct: 651 QLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLI 710
Query: 681 KQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHI 740
K+F QQQ TL T+NVIKEGEDLIQQL RDSA+S+NKTPH+SSI+HI
Sbjct: 711 KRFGQQQQTTLQVTVNVIKEGEDLIQQL-------------RDSAISSNKTPHNSSINHI 757
Query: 741 ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFN 800
E+VLQQLD+AQ QMEELF ERKIKL++FLQLRIFE+ I++ ++L++WN++L +QMNDF+
Sbjct: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFD 817
Query: 801 TEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQ 860
TEDLT+AEQRLQ H ++ L MNN+TF+VI QGQDL QY+ EVQASG+EL+C++D+D+A +
Sbjct: 818 TEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATR 877
Query: 861 VQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNA 920
VQ+LLEFLHEKQ EL+L AEQ K LEQC+QLRHLQAEVKQVLGWIRNGESMLNA L+ A
Sbjct: 878 VQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITA 937
Query: 921 SSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIREC 980
SSL EAEQLQREHEQFQ AIE KTHQSALQVQQKAE +LQA HYD D IR+C
Sbjct: 938 SSLQEAEQLQREHEQFQHAIE---------KTHQSALQVQQKAEAMLQANHYDMDMIRDC 988
Query: 981 AEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLG 1040
AEKVA HWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEY+R+EDWCGG DKLG
Sbjct: 989 AEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLG 1048
Query: 1041 PAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQ 1100
P +E DHV P+ISKHLEQKEAFLKACTLARRNA+VFLKY+HRN+V+MP + +H + PEQQ
Sbjct: 1049 PNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPGMVTHIKAPEQQ 1108
Query: 1101 VKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTST 1160
VK IL+EL QRENRVLH+WT++KRRLDQCQQYVVFERSAKQAL+WI + GEFYLSTHTST
Sbjct: 1109 VKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTST 1168
Query: 1161 GETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHY 1220
G + + TQELLKE+ EF++ AKQTKE+VKLLIQLAD F EKGH HA EI+K VT VDK Y
Sbjct: 1169 GSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRY 1228
Query: 1221 RDFSLRMGKYRYSLEKALGVNTEDN---KDLELDIIPASLSDREVKLRDANHEVNEEKRK 1277
RDFSLRM KYR SLEKALG++++ N K L+LDIIPAS+ EVKLRDA HE+NEEKRK
Sbjct: 1229 RDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRK 1288
Query: 1278 SARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIY 1337
SAR+KEFIMAEL+QTEKAYVRDL EC++TYLWEMTSGVEEIPPGI+NKE IIFGN+QEIY
Sbjct: 1289 SARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIY 1348
Query: 1338 DFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEI 1397
+FHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDS QLILEHAG++FDEI
Sbjct: 1349 EFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEI 1408
Query: 1398 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAM 1457
QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE+KDGLEVMLSVPK+ANDAM
Sbjct: 1409 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAM 1468
Query: 1458 HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGH 1517
H+SMLEGFDEN++ QGELILQ++FQVWDPK+LIRKGRERHLFLFE+SLVFSKE+KDSSG
Sbjct: 1469 HLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGR 1528
Query: 1518 TKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIRE 1577
+KY+YK+KL TSELGVTEHVEGDPCKFALW GRTP+SDNK VLKAS+IE KQ+WIK+IRE
Sbjct: 1529 SKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIRE 1588
Query: 1578 VIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQN 1637
VIQER IHLKGALKEP+ +PKT R +RDG ED+DSQGDGSSQPDTISIASRTSQN
Sbjct: 1589 VIQERTIHLKGALKEPIHIPKTAPATRQKGRRDG-EDLDSQGDGSSQPDTISIASRTSQN 1647
Query: 1638 TVDSDK 1643
T+DSDK
Sbjct: 1648 TLDSDK 1653
Score = 238 bits (606), Expect = 5e-62
Identities = 138/358 (38%), Positives = 211/358 (58%), Gaps = 16/358 (4%)
Query: 1270 EVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHII 1329
E+ E K S +++ +++ EL++TE+ YVRDL +E Y+ M + +P + K+ I+
Sbjct: 1958 EMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKE--DGVPDDMKGKDKIV 2015
Query: 1330 FGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEH 1389
FGNI +IYD+H + FL ELEK + PE +G FV + MY+ YC+NKP S ++ E+
Sbjct: 2016 FGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEY 2075
Query: 1390 AGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGK---GELKDGLEVM 1446
TFF++++QR G ++ LIKPVQRI KYQLLLK+ L ++ EL+ +EVM
Sbjct: 2076 IDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVM 2135
Query: 1447 LSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS-LIRKGRERHLFLFEISL 1505
VP++ ND M+V L+GFD + QG+L+LQD F V D + L+ + RER +FLFE +
Sbjct: 2136 CIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIV 2195
Query: 1506 VFSKEIKDSSGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
+FS+ + G + +++KN + S L + E+VE DPCKFAL S RT +L +S
Sbjct: 2196 IFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTS-RTGDVVETFILHSS 2254
Query: 1564 NIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDG 1621
+ +Q WI I ++++ + L AL P++ QRN+S G G G
Sbjct: 2255 SPSVRQTWIHEINQILENQRNFL-NALTSPIEY------QRNHSGGGGGGGSGGSGGG 2305
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
Length = 580
Score = 231 bits (589), Expect = 4e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 140 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 197
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 198 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 257
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 258 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 317
Query: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 318 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 377
Query: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 378 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 437
Query: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 438 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 490
Query: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
+ +G G P I + + +T
Sbjct: 491 LG--RPRGPGVGSPGRIRLGDQAQGST 515
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
Length = 619
Score = 231 bits (589), Expect = 4e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 179 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 236
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 237 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 296
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 297 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 356
Query: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 357 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 416
Query: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 417 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 476
Query: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 477 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 529
Query: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
+ +G G P I + + +T
Sbjct: 530 LG--RPRGPGVGSPGRIRLGDQAQGST 554
>gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
Length = 696
Score = 229 bits (583), Expect = 2e-59
Identities = 173/659 (26%), Positives = 304/659 (46%), Gaps = 34/659 (5%)
Query: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
++AS +LPILK+K+AF+SGG+D+R G ILT P ++ ++L + YL S+PSE
Sbjct: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCL--EQTNMDELSVTLDYLLSIPSEKC 58
Query: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF----GSS 145
RGFTVI+D R S+W+++K ++ LQ PAE+ + ++KPD FW K+ T+F
Sbjct: 59 KARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKD 118
Query: 146 KFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLE 205
+ FE +VS LT+ ++P QLTE+F GSL Y+H +W+ RL E+F + LL L
Sbjct: 119 RLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELA 178
Query: 206 DLQE-----MLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
+ KE VD+ +D T VL+ E L QR +
Sbjct: 179 LINNGSDKGNQQEKERSVDL-NFLPSVDPET-----VLQTGHELLSELQQRRF------N 226
Query: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
G G D P++ LLD L ++ R + QL +Q
Sbjct: 227 GSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVM 282
Query: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMN---AYVNINRIMSVASR 377
++ +W+ L++ IG S + + LQ +H YV +N+ +A+
Sbjct: 283 QVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQ--QIAAL 340
Query: 378 LSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKM 437
L+ ++K + QL A+ L+ R +L + FH A+ +D M
Sbjct: 341 LNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGM 400
Query: 438 CSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTAT 497
P++ ++ + + + V + + G+ LLD + S + + T
Sbjct: 401 LCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--T 458
Query: 498 ANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGE 557
+ V + V+ ++ ++R E + R++++ Q +QL ++D Q ++W+ +
Sbjct: 459 IENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLD 518
Query: 558 AFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYK 617
A L H +G + L ++H F +VAQ+TY +LL+A L Q+ C
Sbjct: 519 ALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGD 578
Query: 618 AARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAV 676
L + F E+R L+M+++FH++ +++ + + + ++ D ++AV
Sbjct: 579 TLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAV 637
Score = 77.8 bits (190), Expect = 8e-14
Identities = 104/504 (20%), Positives = 215/504 (42%), Gaps = 51/504 (10%)
Query: 773 IFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTF----EV 828
+FE++T E T+ LD L +N+ + ++ Q+ ER + +N + V
Sbjct: 162 VFEKFTKESTSLLDE-----LALINNGS-------DKGNQQEKERSVDLNFLPSVDPETV 209
Query: 829 IQQGQDLHQYITEVQASGIE---LICEKDIDLAAQ--VQELLEFLHEKQHELELNAEQTH 883
+Q G +L + + + +G + D +L AQ V +LL+ L E+ + Q
Sbjct: 210 LQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRS 269
Query: 884 KRLEQCLQLRHLQAEVKQVLGWIRN-GESMLNASLVNASSLSEAEQLQREHEQFQLAIES 942
KR QL +Q +V QV+ W+ G L A S+ ++ LQ++HE+ +
Sbjct: 270 KRT----QLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSE 325
Query: 943 LFHATSLQKTHQSALQVQQKAEVLLQAG-HYDADAIRECAEKVALHWQQLMLKMEDRLKL 1001
F +++ Q+ LL AG D ++ ++++ + ++E R L
Sbjct: 326 WFAVY---------VELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNL 376
Query: 1002 VNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEA 1061
+ A++ F+ ++ + L+ L D G A I + L+ + L+ +
Sbjct: 377 LQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG-------ASIQQTLKLLEEKLKSVDV 429
Query: 1062 FLKACTLARRNAEVFLKYIHRNNVSMP---SVASHTRGPEQQVKAILSELLQRENRVLHF 1118
L+ R + L I N S V + ++ ++ ++ R+ R
Sbjct: 430 GLQGL---REKGQGLLDQIS-NQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDM 485
Query: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
+++ ++ Q Q E A QA++W+ E + L TH G+ +ET+ LL+++ +F
Sbjct: 486 VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFV 545
Query: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
A+ T + + L+Q + + + +++ ++ F++ + + LE A+
Sbjct: 546 DVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAI 605
Query: 1239 GVNTEDNKDL-ELDIIPASLSDRE 1261
++ K L + P +++D E
Sbjct: 606 AFHSNAEKILQDCPEEPEAINDEE 629
Score = 74.7 bits (182), Expect = 7e-13
Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 37/316 (11%)
Query: 178 YNHEEWIELRLSLE----EFFNSAVHLLSRLEDLQEMLARKEFPVD---VEGSRRLIDEH 230
Y +E R +L EF A L +L+ L ML P D ++ + +L++E
Sbjct: 364 YRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE- 422
Query: 231 TQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHS 290
K K + ++ L +GQ LL I ++ + + + + V I +++ +
Sbjct: 423 ---KLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--TIENKENVDHIQGVMEDMQL 477
Query: 291 TRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDL 350
+Q M VR+LK+ Q QL E+DA + +W+S + L++H +G Q L
Sbjct: 478 RKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVL 537
Query: 351 QTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDER 410
+H F + + Y +++ L ++ S+ +L++ WK F A +ER
Sbjct: 538 LEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEER 597
Query: 411 STILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTE 470
L M+ FH AE+ L C E P + D E + E
Sbjct: 598 VHRLEMAIAFHSNAEKILQD-------CPEE--PEAINDEE---------------QFDE 633
Query: 471 VSQDGKALLDVLQRPL 486
+ GK+LLD L P+
Sbjct: 634 IEAVGKSLLDRLTVPV 649
>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
[Homo sapiens]
Length = 985
Score = 226 bits (576), Expect = 1e-58
Identities = 139/354 (39%), Positives = 206/354 (58%), Gaps = 28/354 (7%)
Query: 1282 KEFIMAELLQTEKAYVRDLHECLETYLWEMTSG--VEEIPPGILNKEHIIFGNIQEIYDF 1339
K ++ EL+QTE+ YVR+L+ L Y EM + + +PP + NK+ I+FGN+ EIY+F
Sbjct: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
Query: 1340 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQ 1398
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ FF E Q
Sbjct: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
Query: 1399 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDA 1456
++ + SYL+KPVQRITKYQLLLKELL + EG LK L+ ML + K ND+
Sbjct: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 735
Query: 1457 MHVSMLEGFDENLDVQGELILQDAFQVW--------DPKSLIR-KGRERHLFLFEISLVF 1507
MH + G+ NL+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
Query: 1508 SKEI----KDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
K + S + Y +K+ E+G+TE+V+GD KF +W G + +++AS
Sbjct: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG---EKEEVYIVQAS 852
Query: 1564 NIETKQEWIKNIREVI--QERIIHLKGALKEPLQLPKTP----AKQRNNSKRDG 1611
N++ K W+K IR ++ Q+ ++ +K K+ QL + + Q+N+ K+ G
Sbjct: 853 NVDVKMTWLKEIRNILLKQQELLTVK-KRKQQDQLTERDKFQISLQQNDEKQQG 905
Score = 134 bits (337), Expect = 7e-31
Identities = 104/372 (27%), Positives = 169/372 (45%), Gaps = 26/372 (6%)
Query: 41 EKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDM 100
+ +AF+SGGR K I+TFP N I +E + K++TYL S+ ++ FT+I+D
Sbjct: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
Query: 101 RGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSSKFIFETSMV-- 154
R W +K L+ + +FP +H+ L+++P +F Q+ T+ F F+ + +V
Sbjct: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
Query: 155 -SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLAR 213
SV L +D QLT E G+L Y H EWI R ++E F + + L+ LA
Sbjct: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
Query: 214 KEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD---GFSGR-NCIP 269
E P D+ ++ + + +LK + + +EG+ LL + D S R C
Sbjct: 182 TELPDDIPSIEEILAIRAE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
Query: 270 G-SADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISH 328
S D+Q+ I LL ++H W +LK++Q QL FEQD +++ +
Sbjct: 241 QISGDWQT----INKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEV-- 294
Query: 329 NKELFLQSHTEI----GVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHY 384
E L E+ G Q ++ N NS ++ +L+ HY
Sbjct: 295 --EFLLNQQAELADVTGTIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHY 351
Query: 385 ASQQIKQISTQL 396
A I Q +L
Sbjct: 352 ALDLICQRCNEL 363
Score = 51.2 bits (121), Expect = 8e-06
Identities = 51/242 (21%), Positives = 105/242 (43%), Gaps = 19/242 (7%)
Query: 419 VFHQKAEQFLSGVDAWCKMCSEGG-------LPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
+F E F V +M G LP ++ +E + Y + T V
Sbjct: 153 IFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAV 212
Query: 472 SQDGKALLDVLQRPLSPGN-SESLTATANYS---KAVHQVLDVVHEVLHHQRRLESIWQH 527
+++GK LL L+ P + G S L S + ++++L VH++ + + W+
Sbjct: 213 TKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM---ETAFDGFWEK 269
Query: 528 RKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ + + K+ ++ +E
Sbjct: 270 HQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQVKQKIKKLENLDE 326
Query: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
+Q + A ++ +LA + I + L V ++ +++ L +
Sbjct: 327 NSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFK 386
Query: 646 FH 647
H
Sbjct: 387 MH 388
Score = 45.1 bits (105), Expect = 6e-04
Identities = 58/258 (22%), Positives = 109/258 (42%), Gaps = 32/258 (12%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
+F KE+ ++ E+ E D + +++E++ ++ + V KEG+ L
Sbjct: 160 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 219
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPH---SSSISHIESVLQQLDDAQVQMEELFHER 761
+ L P + G AVS+ H S I +L Q+ D + + + +
Sbjct: 220 LTNLE-VPDTEG--------AVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKH 270
Query: 762 KIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAE-----QRLQRHTE 816
++K++ +LQL FEQ ++ E+ E LL Q + T+A+ ++L+ E
Sbjct: 271 QLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTGTIAQVKQKIKKLENLDE 326
Query: 817 RKLAMNNMTFEVIQQGQDL---HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQH 873
+ + VI G L H Y ++LIC++ +L L+ + K+
Sbjct: 327 NSQELLSKAQFVILHGHKLAANHHY-------ALDLICQRCNELRYLSDILVNEIKAKRI 379
Query: 874 ELELNAEQTHKRLEQCLQ 891
+L + HK L+Q Q
Sbjct: 380 QLS-RTFKMHKLLQQARQ 396
>gi|153791325 MCF.2 cell line derived transforming sequence isoform b
[Homo sapiens]
Length = 925
Score = 226 bits (576), Expect = 1e-58
Identities = 139/354 (39%), Positives = 206/354 (58%), Gaps = 28/354 (7%)
Query: 1282 KEFIMAELLQTEKAYVRDLHECLETYLWEMTSG--VEEIPPGILNKEHIIFGNIQEIYDF 1339
K ++ EL+QTE+ YVR+L+ L Y EM + + +PP + NK+ I+FGN+ EIY+F
Sbjct: 496 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 555
Query: 1340 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQ 1398
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ FF E Q
Sbjct: 556 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 615
Query: 1399 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDA 1456
++ + SYL+KPVQRITKYQLLLKELL + EG LK L+ ML + K ND+
Sbjct: 616 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 675
Query: 1457 MHVSMLEGFDENLDVQGELILQDAFQVW--------DPKSLIR-KGRERHLFLFEISLVF 1507
MH + G+ NL+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 676 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 735
Query: 1508 SKEI----KDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
K + S + Y +K+ E+G+TE+V+GD KF +W G + +++AS
Sbjct: 736 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG---EKEEVYIVQAS 792
Query: 1564 NIETKQEWIKNIREVI--QERIIHLKGALKEPLQLPKTP----AKQRNNSKRDG 1611
N++ K W+K IR ++ Q+ ++ +K K+ QL + + Q+N+ K+ G
Sbjct: 793 NVDVKMTWLKEIRNILLKQQELLTVK-KRKQQDQLTERDKFQISLQQNDEKQQG 845
Score = 85.5 bits (210), Expect = 4e-16
Identities = 77/295 (26%), Positives = 126/295 (42%), Gaps = 26/295 (8%)
Query: 118 AFPAEIHVALIIKPDNFWQKQKTNFG----SSKFIFETSMV---SVEGLTKLVDPSQLTE 170
+FP +H+ L+++P +F Q+ T+ G F+ + +V SV L +D QLT
Sbjct: 19 SFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTP 78
Query: 171 EFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEH 230
E G+L Y H EWI R ++E F + + L+ LA E P D+ ++
Sbjct: 79 ELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIR 138
Query: 231 TQLKKKVLKAPVEELDREGQRLLQCIRCSD---GFSGR-NCIPG-SADFQSLVPKITSLL 285
+ + +LK + + +EG+ LL + D S R C S D+Q+ I LL
Sbjct: 139 AE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQT----INKLL 193
Query: 286 DKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEI----G 341
++H W +LK++Q QL FEQD +++ + E L E+ G
Sbjct: 194 TQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTG 249
Query: 342 VSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQL 396
Q ++ N NS ++ +L+ HYA I Q +L
Sbjct: 250 TIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNEL 303
Score = 51.2 bits (121), Expect = 8e-06
Identities = 51/242 (21%), Positives = 105/242 (43%), Gaps = 19/242 (7%)
Query: 419 VFHQKAEQFLSGVDAWCKMCSEGG-------LPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
+F E F V +M G LP ++ +E + Y + T V
Sbjct: 93 IFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAV 152
Query: 472 SQDGKALLDVLQRPLSPGN-SESLTATANYS---KAVHQVLDVVHEVLHHQRRLESIWQH 527
+++GK LL L+ P + G S L S + ++++L VH++ + + W+
Sbjct: 153 TKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM---ETAFDGFWEK 209
Query: 528 RKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ + + K+ ++ +E
Sbjct: 210 HQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQVKQKIKKLENLDE 266
Query: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
+Q + A ++ +LA + I + L V ++ +++ L +
Sbjct: 267 NSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFK 326
Query: 646 FH 647
H
Sbjct: 327 MH 328
Score = 45.1 bits (105), Expect = 6e-04
Identities = 58/258 (22%), Positives = 109/258 (42%), Gaps = 32/258 (12%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
+F KE+ ++ E+ E D + +++E++ ++ + V KEG+ L
Sbjct: 100 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 159
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPH---SSSISHIESVLQQLDDAQVQMEELFHER 761
+ L P + G AVS+ H S I +L Q+ D + + + +
Sbjct: 160 LTNLE-VPDTEG--------AVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKH 210
Query: 762 KIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAE-----QRLQRHTE 816
++K++ +LQL FEQ ++ E+ E LL Q + T+A+ ++L+ E
Sbjct: 211 QLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTGTIAQVKQKIKKLENLDE 266
Query: 817 RKLAMNNMTFEVIQQGQDL---HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQH 873
+ + VI G L H Y ++LIC++ +L L+ + K+
Sbjct: 267 NSQELLSKAQFVILHGHKLAANHHY-------ALDLICQRCNELRYLSDILVNEIKAKRI 319
Query: 874 ELELNAEQTHKRLEQCLQ 891
+L + HK L+Q Q
Sbjct: 320 QLS-RTFKMHKLLQQARQ 336
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 226 bits (575), Expect = 2e-58
Identities = 167/522 (31%), Positives = 263/522 (50%), Gaps = 47/522 (9%)
Query: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
+ L + +D+CQ + A+ AL I++ E T +E + KEY
Sbjct: 503 YLLASQPVDKCQS----QDGAEAALQEIEKFLE------TGAENKIQELNAIYKEYES-- 550
Query: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
+ + E V+ + Q S E H ++K + + + R S +
Sbjct: 551 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 610
Query: 1239 GVNT-EDNKDLELDII---PASLSDREV-KLRDANHEVNEEKRKSARKKEFIMAELLQTE 1293
G+ +N E + P + E+ + R EE+ A + +M+ELL TE
Sbjct: 611 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 670
Query: 1294 KAYVRDLHECLETYLWEMTSGVEE--IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKY 1351
+AYV +L LE Y EM + + + G+ NK+ ++FGN++EIY FHN IFL+ELE Y
Sbjct: 671 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 730
Query: 1352 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQQRHGLANSISSY 1410
PE VG CF+ + FQ+Y YC+NKP S L + + FF E Q++ S+ SY
Sbjct: 731 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 790
Query: 1411 LIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDEN 1468
L+KPVQRITKYQLLLKE+L EG +L++ L +L + K ND+MH+ + G+D N
Sbjct: 791 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 850
Query: 1469 LDVQGELILQDAFQVWDP--------KSLIR-KGRERHLFLFEISLVFSKEIKDS-SGHT 1518
L G+L++Q +F VW K L R K +RHLFL E +++F K+ +++ G+
Sbjct: 851 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 910
Query: 1519 K---YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNI 1575
K Y YK L + +G+TE+V+GD KF +W + + +++A E K W+ I
Sbjct: 911 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 967
Query: 1576 REVIQERIIHLKGALKE---------PLQLPKTPAKQRNNSK 1608
R+V+ ++ + A + PL P + + R NS+
Sbjct: 968 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSR 1009
Score = 163 bits (412), Expect = 1e-39
Identities = 136/521 (26%), Positives = 230/521 (44%), Gaps = 51/521 (9%)
Query: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
L A+D+ LK++ A++SGGR + G P++TFP I ++ + ++TYL S+PS
Sbjct: 94 LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD 153
Query: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSS 145
GF ++ID R KW +K + + +FPA + + L+++P F+Q+ ++ F
Sbjct: 154 AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD 213
Query: 146 KFIFETSMV---SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
F + ++ SV L +D SQLTE+ G+LDY H W+ R ++E F
Sbjct: 214 DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ 273
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
L+ LA E P DV+ + ++ HT+ K K K + +EG +L+ +R
Sbjct: 274 MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKA-KEDLRLALKEGHSVLESLRELQAE 332
Query: 263 SGRNCI-PGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQ---D 318
+ D Q+ V + LL +L+ T + W + KL+QC QLR FEQ +
Sbjct: 333 GSEPSVNQDQLDNQATVQR---LLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE 389
Query: 319 AEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRL 378
+ + D S + + T+IG S + L F S A + +L
Sbjct: 390 VKAILDAASQK----IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQL 445
Query: 379 SEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMC 438
HYA I+ +L F+A + R +L+ S H++ E + K C
Sbjct: 446 IGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM-------KWC 498
Query: 439 SEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEV-SQDG-KALLDVLQRPLSPGNSESL-- 494
EG +Y +Q + SQDG +A L +++ L G +
Sbjct: 499 DEG------------------IYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE 540
Query: 495 --TATANYSKAVHQ-VLDVVHEVLHHQRRLESIWQHRKVRL 532
Y ++Q +++ V +V Q +E ++ R+ L
Sbjct: 541 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASL 581
Score = 58.9 bits (141), Expect = 4e-08
Identities = 73/319 (22%), Positives = 128/319 (40%), Gaps = 33/319 (10%)
Query: 803 DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKD-IDLAAQV 861
D+ L HTE+K +++G + + + E+QA G E +D +D A V
Sbjct: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
Query: 862 QELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNAS 921
Q LL L+E + + + ++LEQCLQLRH + ++V + + +
Sbjct: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGN 409
Query: 922 SLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECA 981
SL+ E L R+ F+ ++++ +L +Q L+ HY D+IR
Sbjct: 410 SLAHVEHLLRDLASFEEK-----SGVAVERARALSLDGEQ----LIGNKHYAVDSIRPKC 460
Query: 982 EKVALHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
+++ Q ++ R L++ S+ ++ TS + C E + + D C +D
Sbjct: 461 QELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLASQPVDKCQSQD- 517
Query: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKAC----------TLARRNAEVFLK------YIHR 1082
G A + + + E K L A L +VF K HR
Sbjct: 518 -GAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHR 576
Query: 1083 NNVSMPSVASHTRGPEQQV 1101
S+ +A+ P Q V
Sbjct: 577 RQASLKKLAARQTRPVQPV 595
Score = 56.6 bits (135), Expect = 2e-07
Identities = 75/365 (20%), Positives = 140/365 (38%), Gaps = 44/365 (12%)
Query: 407 LDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQ 466
L +R+ I + + + Q A+ S + +E LP+++Q + H ++ +
Sbjct: 255 LCQRTAIESFALMVKQTAQMLQS----FGTELAETELPNDVQSTSSVLCAHTEKKDKAKE 310
Query: 467 AYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQ 526
++G ++L+ L+ + G+ S+ ++A Q L + ++ + + W
Sbjct: 311 DLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRL--LAQLNETEAAFDEFWA 368
Query: 527 HRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEV 586
+ +L Q LQL F+Q ++V ++ + ++ T +G SL L + FEE
Sbjct: 369 KHQQKLEQCLQLRHFEQGFREVKAILDAASQK-IATFTDIGNSLAHVEHLLRDLASFEEK 427
Query: 587 AQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSF 646
+ A L EQL + I + L F + +R+ LL S+
Sbjct: 428 SGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLEL 487
Query: 647 HTHTKELWTWMED---LQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVI-KE 700
H + W ++ L D C D +A + I++F + LN I KE
Sbjct: 488 HRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKE 547
Query: 701 GEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHE 760
E ++ Q + H+ V Q+ Q MEE+FH
Sbjct: 548 YESILNQ---------------------------DLMEHVRKVFQK----QASMEEVFHR 576
Query: 761 RKIKL 765
R+ L
Sbjct: 577 RQASL 581
Score = 48.5 bits (114), Expect = 5e-05
Identities = 66/325 (20%), Positives = 136/325 (41%), Gaps = 36/325 (11%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
SF K+ ++ E+ E + V + ++ +++ + +KEG +
Sbjct: 263 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 322
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIK 764
++ LR EPS +D + N T ++ +L QL++ + +E + + + K
Sbjct: 323 LESLRELQAEGSEPSVNQDQ-LDNQAT--------VQRLLAQLNETEAAFDEFWAKHQQK 373
Query: 765 LDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNT--------EDLTLAEQRLQRHTE 816
L+ LQLR FEQ EV A LDA ++ + + N+ DL E++ E
Sbjct: 374 LEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVE 433
Query: 817 RKLAMNNMTFEVIQQGQDLHQYITEVQASGIEL--ICEKDIDLAAQVQELLEFLHEKQHE 874
R A++ ++I + H + ++ EL +C++ A+ + LL E
Sbjct: 434 RARALSLDGEQLI---GNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRR 490
Query: 875 LELNAE--------QTHKRLEQCLQLRHLQAEVKQVLGWIRNGE----SMLNASLVNASS 922
LE + + + +++C +A ++++ ++ G LNA S
Sbjct: 491 LETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYES 550
Query: 923 LSEAEQLQREHEQF--QLAIESLFH 945
+ + ++ + F Q ++E +FH
Sbjct: 551 ILNQDLMEHVRKVFQKQASMEEVFH 575
Score = 48.1 bits (113), Expect = 7e-05
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 3/197 (1%)
Query: 1044 EIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNV--SMPSVASHTRGPEQQV 1101
++ ++ H E+K+ + LA + L+ + S PSV + V
Sbjct: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
Query: 1102 KAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTG 1161
+ +L++L + E FW +++L+QC Q FE+ ++ + I + ++T T G
Sbjct: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDIG 408
Query: 1162 ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYR 1221
+ + LL++ F + E+ + L + + H IR +
Sbjct: 409 NSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCD 468
Query: 1222 DFSLRMGKYRYSLEKAL 1238
FS + + R L K+L
Sbjct: 469 QFSAEIARRRGLLSKSL 485
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 226 bits (575), Expect = 2e-58
Identities = 167/522 (31%), Positives = 263/522 (50%), Gaps = 47/522 (9%)
Query: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
+ L + +D+CQ + A+ AL I++ E T +E + KEY
Sbjct: 450 YLLASQPVDKCQS----QDGAEAALQEIEKFLE------TGAENKIQELNAIYKEYES-- 497
Query: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
+ + E V+ + Q S E H ++K + + + R S +
Sbjct: 498 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 557
Query: 1239 GVNT-EDNKDLELDII---PASLSDREV-KLRDANHEVNEEKRKSARKKEFIMAELLQTE 1293
G+ +N E + P + E+ + R EE+ A + +M+ELL TE
Sbjct: 558 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 617
Query: 1294 KAYVRDLHECLETYLWEMTSGVEE--IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKY 1351
+AYV +L LE Y EM + + + G+ NK+ ++FGN++EIY FHN IFL+ELE Y
Sbjct: 618 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 677
Query: 1352 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQQRHGLANSISSY 1410
PE VG CF+ + FQ+Y YC+NKP S L + + FF E Q++ S+ SY
Sbjct: 678 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 737
Query: 1411 LIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDEN 1468
L+KPVQRITKYQLLLKE+L EG +L++ L +L + K ND+MH+ + G+D N
Sbjct: 738 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 797
Query: 1469 LDVQGELILQDAFQVWDP--------KSLIR-KGRERHLFLFEISLVFSKEIKDS-SGHT 1518
L G+L++Q +F VW K L R K +RHLFL E +++F K+ +++ G+
Sbjct: 798 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 857
Query: 1519 K---YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNI 1575
K Y YK L + +G+TE+V+GD KF +W + + +++A E K W+ I
Sbjct: 858 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 914
Query: 1576 REVIQERIIHLKGALKE---------PLQLPKTPAKQRNNSK 1608
R+V+ ++ + A + PL P + + R NS+
Sbjct: 915 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSR 956
Score = 166 bits (420), Expect = 2e-40
Identities = 142/548 (25%), Positives = 238/548 (43%), Gaps = 59/548 (10%)
Query: 11 LWYLRLLRLLDRGSFRNDGLKASDVLPI--------LKEKVAFVSGGRDKRGGPILTFPA 62
LW L R G R D + D++P+ LK++ A++SGGR + G P++TFP
Sbjct: 14 LWSLPRRRRGTAGRSRPDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPD 73
Query: 63 RSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAE 122
I ++ + ++TYL S+PS GF ++ID R KW +K + + +FPA
Sbjct: 74 YPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPAN 133
Query: 123 IHVALIIKPDNFWQKQKTN----FGSSKFIFETSMV---SVEGLTKLVDPSQLTEEFDGS 175
+ + L+++P F+Q+ ++ F F + ++ SV L +D SQLTE+ G+
Sbjct: 134 LQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGT 193
Query: 176 LDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKK 235
LDY H W+ R ++E F L+ LA E P DV+ + ++ HT+ K
Sbjct: 194 LDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKD 253
Query: 236 KVLKAPVEELDREGQRLLQCIRCSDGFSGRNCI-PGSADFQSLVPKITSLLDKLHSTRQH 294
K K + +EG +L+ +R + D Q+ V + LL +L+ T
Sbjct: 254 KA-KEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQR---LLAQLNETEAA 309
Query: 295 LHQMWHVRKLKLDQCFQLRLFEQ---DAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQ 351
+ W + KL+QC QLR FEQ + + + D S + + T+IG S + L
Sbjct: 310 FDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQK----IATFTDIGNSLAHVEHLL 365
Query: 352 TQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERS 411
F S A + +L HYA I+ +L F+A + R
Sbjct: 366 RDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRR 425
Query: 412 TILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
+L+ S H++ E + K C EG +Y +Q +
Sbjct: 426 GLLSKSLELHRRLETSM-------KWCDEG------------------IYLLASQPVDKC 460
Query: 472 -SQDG-KALLDVLQRPLSPGNSESL----TATANYSKAVHQ-VLDVVHEVLHHQRRLESI 524
SQDG +A L +++ L G + Y ++Q +++ V +V Q +E +
Sbjct: 461 QSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEV 520
Query: 525 WQHRKVRL 532
+ R+ L
Sbjct: 521 FHRRQASL 528
Score = 58.9 bits (141), Expect = 4e-08
Identities = 73/319 (22%), Positives = 128/319 (40%), Gaps = 33/319 (10%)
Query: 803 DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKD-IDLAAQV 861
D+ L HTE+K +++G + + + E+QA G E +D +D A V
Sbjct: 237 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 296
Query: 862 QELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNAS 921
Q LL L+E + + + ++LEQCLQLRH + ++V + + +
Sbjct: 297 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGN 356
Query: 922 SLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECA 981
SL+ E L R+ F+ ++++ +L +Q L+ HY D+IR
Sbjct: 357 SLAHVEHLLRDLASFEEK-----SGVAVERARALSLDGEQ----LIGNKHYAVDSIRPKC 407
Query: 982 EKVALHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
+++ Q ++ R L++ S+ ++ TS + C E + + D C +D
Sbjct: 408 QELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLASQPVDKCQSQD- 464
Query: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKAC----------TLARRNAEVFLK------YIHR 1082
G A + + + E K L A L +VF K HR
Sbjct: 465 -GAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHR 523
Query: 1083 NNVSMPSVASHTRGPEQQV 1101
S+ +A+ P Q V
Sbjct: 524 RQASLKKLAARQTRPVQPV 542
Score = 56.6 bits (135), Expect = 2e-07
Identities = 75/365 (20%), Positives = 140/365 (38%), Gaps = 44/365 (12%)
Query: 407 LDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQ 466
L +R+ I + + + Q A+ S + +E LP+++Q + H ++ +
Sbjct: 202 LCQRTAIESFALMVKQTAQMLQS----FGTELAETELPNDVQSTSSVLCAHTEKKDKAKE 257
Query: 467 AYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQ 526
++G ++L+ L+ + G+ S+ ++A Q L + ++ + + W
Sbjct: 258 DLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRL--LAQLNETEAAFDEFWA 315
Query: 527 HRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEV 586
+ +L Q LQL F+Q ++V ++ + ++ T +G SL L + FEE
Sbjct: 316 KHQQKLEQCLQLRHFEQGFREVKAILDAASQK-IATFTDIGNSLAHVEHLLRDLASFEEK 374
Query: 587 AQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSF 646
+ A L EQL + I + L F + +R+ LL S+
Sbjct: 375 SGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLEL 434
Query: 647 HTHTKELWTWMED---LQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVI-KE 700
H + W ++ L D C D +A + I++F + LN I KE
Sbjct: 435 HRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKE 494
Query: 701 GEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHE 760
E ++ Q + H+ V Q+ Q MEE+FH
Sbjct: 495 YESILNQ---------------------------DLMEHVRKVFQK----QASMEEVFHR 523
Query: 761 RKIKL 765
R+ L
Sbjct: 524 RQASL 528
Score = 48.5 bits (114), Expect = 5e-05
Identities = 66/325 (20%), Positives = 136/325 (41%), Gaps = 36/325 (11%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
SF K+ ++ E+ E + V + ++ +++ + +KEG +
Sbjct: 210 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 269
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIK 764
++ LR EPS +D + N T ++ +L QL++ + +E + + + K
Sbjct: 270 LESLRELQAEGSEPSVNQDQ-LDNQAT--------VQRLLAQLNETEAAFDEFWAKHQQK 320
Query: 765 LDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNT--------EDLTLAEQRLQRHTE 816
L+ LQLR FEQ EV A LDA ++ + + N+ DL E++ E
Sbjct: 321 LEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVE 380
Query: 817 RKLAMNNMTFEVIQQGQDLHQYITEVQASGIEL--ICEKDIDLAAQVQELLEFLHEKQHE 874
R A++ ++I + H + ++ EL +C++ A+ + LL E
Sbjct: 381 RARALSLDGEQLI---GNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRR 437
Query: 875 LELNAE--------QTHKRLEQCLQLRHLQAEVKQVLGWIRNGE----SMLNASLVNASS 922
LE + + + +++C +A ++++ ++ G LNA S
Sbjct: 438 LETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYES 497
Query: 923 LSEAEQLQREHEQF--QLAIESLFH 945
+ + ++ + F Q ++E +FH
Sbjct: 498 ILNQDLMEHVRKVFQKQASMEEVFH 522
Score = 48.1 bits (113), Expect = 7e-05
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 3/197 (1%)
Query: 1044 EIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNV--SMPSVASHTRGPEQQV 1101
++ ++ H E+K+ + LA + L+ + S PSV + V
Sbjct: 237 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 296
Query: 1102 KAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTG 1161
+ +L++L + E FW +++L+QC Q FE+ ++ + I + ++T T G
Sbjct: 297 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDIG 355
Query: 1162 ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYR 1221
+ + LL++ F + E+ + L + + H IR +
Sbjct: 356 NSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCD 415
Query: 1222 DFSLRMGKYRYSLEKAL 1238
FS + + R L K+L
Sbjct: 416 QFSAEIARRRGLLSKSL 432
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 218 bits (554), Expect = 5e-56
Identities = 121/327 (37%), Positives = 200/327 (61%), Gaps = 11/327 (3%)
Query: 1273 EEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGN 1332
E+K K+ R + F++ EL+QTEK YV+DL +E ++ + + +P + K+ I+FGN
Sbjct: 224 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE--KGVPEDMRGKDKIVFGN 281
Query: 1333 IQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGT 1392
I +IYD+H + FL ELEK Q + + F+ K +YV YC+NKP S ++ E+
Sbjct: 282 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 340
Query: 1393 FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD---GLEVMLSV 1449
+F+E++Q ++S +LIKP+QRITKYQLLLK+ L E+ E D +E+M V
Sbjct: 341 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400
Query: 1450 PKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD-PKSLIRKGRERHLFLFEISLVFS 1508
PK+ ND M++ L+GF+ L QG+L+ QD F V + + + +ER +FLFE ++FS
Sbjct: 401 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFS 460
Query: 1509 KEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETK 1568
+ ++ S Y++K + + L + E+V+ DPCKFAL + T + VL+A+N + +
Sbjct: 461 ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET---SERVVLQAANADIQ 517
Query: 1569 QEWIKNIREVIQERIIHLKGALKEPLQ 1595
Q W+++I +V++ + L AL+ P++
Sbjct: 518 QAWVQDINQVLETQRDFL-NALQSPIE 543
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 199 bits (507), Expect = 1e-50
Identities = 117/334 (35%), Positives = 178/334 (53%), Gaps = 14/334 (4%)
Query: 1254 PASLSDREVKLRDANHEVNEEKRKS--ARKKEFIMAELLQTEKAYVRDLHECLETYLWEM 1311
P R + H E+ R+ + + IMAE++ TE+ Y+R L ++ Y EM
Sbjct: 776 PPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEM 835
Query: 1312 TSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQM 1371
++P G+ K H+IFGN+++++DFH FL+ELE+ + P VG F+ ++F M
Sbjct: 836 ER--MDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGM 893
Query: 1372 YVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTC 1431
YV Y KNKP S+ L+ H FF + Q+ G ++SYL++PVQR+ KY LLL++LL
Sbjct: 894 YVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKE 953
Query: 1432 CEEG------KGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD 1485
G GEL+ V+ + ND + + + G D NL QG+L +D F V
Sbjct: 954 ASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-- 1011
Query: 1486 PKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFA 1545
RK RH+FLFE ++FSK K H Y+YK T+E+G+TE+V +F
Sbjct: 1012 --CCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFE 1069
Query: 1546 LWSGRTPSSDNKTVLKASNIETKQEWIKNIREVI 1579
+W R S + +L+AS+ E K W I ++
Sbjct: 1070 IWFRRRRKSQDTYILQASSAEVKSAWTDVIGRIL 1103
Score = 77.4 bits (189), Expect = 1e-13
Identities = 73/282 (25%), Positives = 126/282 (44%), Gaps = 29/282 (10%)
Query: 38 ILKEKVAFVSGGRDKRGGPILTFPARS---NHDRIRQEDLRKLVTYLASVPSEDVCKRGF 94
+L+ V + G RD+ G ++ RS + +L +L+ Y S+P ++V G
Sbjct: 197 LLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGL 256
Query: 95 TVIIDMRGSKW-DLIKPLLKTLQEAFPAEIH-VALIIKPDNFWQKQKTNFGSSKFIFETS 152
V++D R S + L LQ IH + L++ ++ ++ K I +
Sbjct: 257 VVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDA------IIQCE 310
Query: 153 MVS-VEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEML 211
+VS ++ + K VD QLT + DGS Y+H +WI R LE F + + L++ L
Sbjct: 311 VVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSL 370
Query: 212 ARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG 270
P + LID+H + K VL+ P + L EG +L +R + G
Sbjct: 371 NTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE--------LG 422
Query: 271 SADFQSLVPKITSLLDKLH--------STRQHLHQMWHVRKL 304
+ D + + TSL D++ ++ L Q+ H+R+L
Sbjct: 423 TEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLREL 464
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 178 bits (451), Expect = 4e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 704
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 705 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 764
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 824
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 825 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 877
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 878 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 936
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 937 WTADISHLLWRQAVHNK 953
Score = 52.4 bits (124), Expect = 4e-06
Identities = 62/288 (21%), Positives = 117/288 (40%), Gaps = 32/288 (11%)
Query: 39 LKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLASVPSEDVCKRGFT 95
+ ++ G RD +G +L A S ++L +L+ YL S+P +V G T
Sbjct: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
Query: 96 VIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMV 154
V++D R + + L LQEA P ++ L++ T + +
Sbjct: 169 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLLKEVPSGLQLEQL 220
Query: 155 SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARK 214
+ L + + L G L Y H+ W++ R LE + + L+ E +
Sbjct: 221 PSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAV 280
Query: 215 EFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG--- 270
P++ +L+ + L ++VL +P + L +G R L ++ +P
Sbjct: 281 PQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE--------VPEVTL 332
Query: 271 SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 333 SPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 377
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 178 bits (451), Expect = 4e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 54.3 bits (129), Expect = 1e-06
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
Query: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
Query: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
Query: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 178 bits (451), Expect = 4e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 54.3 bits (129), Expect = 1e-06
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
Query: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
Query: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
Query: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 178 bits (451), Expect = 4e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 54.3 bits (129), Expect = 1e-06
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
Query: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
Query: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
Query: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 178 bits (451), Expect = 4e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 54.3 bits (129), Expect = 1e-06
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
Query: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
Query: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
Query: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 170 bits (430), Expect = 1e-41
Identities = 120/419 (28%), Positives = 191/419 (45%), Gaps = 25/419 (5%)
Query: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
L A +++ L + A +SGGR + G PI+TFP S I ED ++TYL S+PS +
Sbjct: 36 LMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEA 95
Query: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFG----SS 145
GF V+ID R KW +K L + AFP + + I++P F Q+ T+ G +
Sbjct: 96 ASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRN 155
Query: 146 KFIFETSMVSVEGLTKL---VDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
+F + ++ V ++ L +D SQLT E G+L+Y H +W+ R ++E F +
Sbjct: 156 EFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ 215
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
L+ LA E P + + L+ HT+ + K L+ ++ L ++G LL CI+
Sbjct: 216 MLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDK-LQDELKLLGKQGTTLLSCIQ----E 270
Query: 263 SGRNCIPGSADFQSL--VPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQD-- 318
C + L V + LL +L T + W LKL+QC QL+ FE D
Sbjct: 271 PATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFC 330
Query: 319 -AEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASR 377
A+ D + + F T IG S + + +H S + V +
Sbjct: 331 KAKLALDNLLEEQAEF----TGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQ 386
Query: 378 LSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCK 436
L ++ HYA+ I+ +L F ++ IL S FH++ L V WC+
Sbjct: 387 LIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQ----LDKVSQWCE 441
Score = 125 bits (314), Expect = 3e-28
Identities = 114/409 (27%), Positives = 187/409 (45%), Gaps = 59/409 (14%)
Query: 1233 SLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEV--------NEEKRKSARKKEF 1284
S+ A + T + E ++ D E K + E+ N E + AR +
Sbjct: 558 SVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDL 617
Query: 1285 -----IMAELLQTEKAYVRDLHECLETYLWEMTS-GVEEIPPGIL-NKEHIIFGNIQEIY 1337
I+ +LL+TE+ Y++++ ++ Y+ M ++ + P +L N + +FGNI+E+Y
Sbjct: 618 SPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELY 677
Query: 1338 DFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEI 1397
+FHN FLKELEK + PE + HCF+ + Q+Y Y KN P + + E + +
Sbjct: 678 EFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGV 737
Query: 1398 QQR---HGLANSISSYLIKPVQRITKYQLLLKELLTC-----CEEGKGEL----KDG--- 1442
QR H L + YL P QR+ KYQ+LLK LL E GEL KDG
Sbjct: 738 CQRQLDHNL--PLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKR 795
Query: 1443 -------------LEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVW----- 1484
L V+ + K A+ ++ + +++ G+L+L F VW
Sbjct: 796 TKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKD 855
Query: 1485 --DPKSLIR-KGRERHLFLFEISLVFSK---EIKDSSGHTKYVYKNKLLTSELGVTEHVE 1538
K LIR K +R ++LFE +VF K E D Y +K + L + +
Sbjct: 856 RYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGR 915
Query: 1539 GDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLK 1587
G KF + S + K +L+A++ E + W I +++ E+ ++K
Sbjct: 916 GSHRKFEIAS---RNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIK 961
Score = 58.9 bits (141), Expect = 4e-08
Identities = 95/441 (21%), Positives = 170/441 (38%), Gaps = 70/441 (15%)
Query: 335 QSHTEIGVSYQYALDLQTQHNHFAMNS---MNAYVNINRIMSVASRLSEAGHYASQQIKQ 391
++ T+IG+ Y Y + +T+ +NS ++ Y++ +++ E H
Sbjct: 143 RTFTDIGIKY-YRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRH-------- 193
Query: 392 ISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLE 451
+W + A++ + L +A Q + F S C +E LP M E
Sbjct: 194 ------GQWVNHRTAIENFALTLKTTA---QMLQTFGS-----CLATAE--LPRSMLSTE 237
Query: 452 LAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLS--PGNSESLTATANYSKAVHQVLD 509
+ H +++ + + G LL +Q P + P + +L N + + ++L
Sbjct: 238 DLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVT-TMERLLV 296
Query: 510 VVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKS 569
+ E ++ W ++L+Q LQL F+ D + ++N E ++ TG+G S
Sbjct: 297 QLDET---EKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEE-QAEFTGIGDS 352
Query: 570 LHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDF 629
+ + K H EE +Q A L +QL Q+ + I L DF
Sbjct: 353 VMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDF 412
Query: 630 VRRVEQRKLLLDMSVSFHTHTKELWTWMED---LQKEMLEDVC--ADSVDAVQELIKQFQ 684
+ +++ +L S+ FH ++ W E L D C + VD I F
Sbjct: 413 INGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATF- 471
Query: 685 QQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVL 744
L +KE L +P E + + K + VL
Sbjct: 472 ----------LGTVKEYPLL------SPKEFYNEFELLLTLDAKAKA---------QKVL 506
Query: 745 QQLDDAQVQMEELFHERKIKL 765
Q+LDD Q E+FH+R++ L
Sbjct: 507 QRLDDVQ----EIFHKRQVSL 523
Score = 56.2 bits (134), Expect = 3e-07
Identities = 49/205 (23%), Positives = 89/205 (43%), Gaps = 15/205 (7%)
Query: 1051 LISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQ--QVKAILSEL 1108
L+ H Q++ L + L I P+ + E ++ +L +L
Sbjct: 239 LLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQL 298
Query: 1109 LQRENRVLHFWTLKKRRLDQCQQYVVFER---SAKQALD-WIQETGEFYLSTHTSTGETT 1164
+ E HFW+ +L+QC Q FE AK ALD ++E EF T G++
Sbjct: 299 DETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEF-----TGIGDSV 353
Query: 1165 EETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFS 1224
+++LKE+ + +++ EK +LL + D ++ H A IR + +H D
Sbjct: 354 MHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVEL-RHLCDDF 412
Query: 1225 LRMGKYRYSLEKALGVNTEDNKDLE 1249
+ K ++ + LG + E ++ L+
Sbjct: 413 INGNKKKWDI---LGKSLEFHRQLD 434
Score = 38.9 bits (89), Expect = 0.042
Identities = 49/191 (25%), Positives = 81/191 (42%), Gaps = 29/191 (15%)
Query: 800 NTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYI----TEVQASGIELICEKDI 855
+TEDL L HT ++ + + + +QG L I T+ S + L +
Sbjct: 235 STEDL------LMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNL---NQL 285
Query: 856 DLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQ---AEVKQVLGWIRNGESM 912
+ ++ LL L E + + H +L QCLQL+H + + K L + ++
Sbjct: 286 ENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAE 345
Query: 913 LNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHY 972
S+ EQ+ +EH++ + + L+K AL Q L+Q+ HY
Sbjct: 346 FTGI---GDSVMHVEQILKEHKKLEEKSQE-----PLEKAQLLALVGDQ----LIQSHHY 393
Query: 973 DADAIR-ECAE 982
ADAIR C E
Sbjct: 394 AADAIRPRCVE 404
Score = 31.2 bits (69), Expect = 8.8
Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 17/146 (11%)
Query: 672 SVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPS-EARDSAVSNNK 730
S+ + ++L+ +Q+ D + K+G L+ ++ EP+ + +S ++ N+
Sbjct: 232 SMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQ-------EPATKCPNSKLNLNQ 284
Query: 731 TPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNE 790
+++ +E +L QLD+ + + E +KL+ LQL+ FE + LD
Sbjct: 285 L---ENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALD---- 337
Query: 791 DLLRQMNDFN--TEDLTLAEQRLQRH 814
+LL + +F + + EQ L+ H
Sbjct: 338 NLLEEQAEFTGIGDSVMHVEQILKEH 363
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 134 bits (336), Expect = 1e-30
Identities = 97/329 (29%), Positives = 172/329 (52%), Gaps = 23/329 (6%)
Query: 1271 VNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIF 1330
V+E++ K+ + ++ ELL +E+A+V +L + L+++ + +P + ++ +IF
Sbjct: 5685 VSEDEYKA--RLSSVIQELLSSEQAFVEEL-QFLQSHHLQHLERCPHVPIAVAGQKAVIF 5741
Query: 1331 GNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHA 1390
N+++I FH++ FL+EL++ + +DV CF+ F+ Y+ + + + +++ A
Sbjct: 5742 RNVRDIGRFHSS-FLQELQQCDT-DDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTA 5799
Query: 1391 -GTFFDEIQQRHGLANSISS--------YLIKPVQRITKYQLLLKELLTCCEEGKGE--- 1438
F+ + + LA S YL +PV+R+ +YQ LLKEL+ +
Sbjct: 5800 IQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNRQNCAL 5859
Query: 1439 LKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIR---KGRE 1495
L+ V+ ++P++A + +HVS++E + L GE I Q F VW+ R KG
Sbjct: 5860 LEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMPWKGHN 5919
Query: 1496 RHLFLFEISLVFSKEIKDSSGHT-KYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSS 1554
RH+FLF LV K +DS T YV++N + S + + + VEGD F +W R S
Sbjct: 5920 RHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQER-EDS 5978
Query: 1555 DNKTVLKASNIETKQEWIKNIREVIQERI 1583
K +L+A K W+K I IQ+R+
Sbjct: 5979 VRKYLLQARTAIIKSSWVKEICG-IQQRL 6006
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 134 bits (336), Expect = 1e-30
Identities = 97/329 (29%), Positives = 172/329 (52%), Gaps = 23/329 (6%)
Query: 1271 VNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIF 1330
V+E++ K+ + ++ ELL +E+A+V +L + L+++ + +P + ++ +IF
Sbjct: 5685 VSEDEYKA--RLSSVIQELLSSEQAFVEEL-QFLQSHHLQHLERCPHVPIAVAGQKAVIF 5741
Query: 1331 GNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHA 1390
N+++I FH++ FL+EL++ + +DV CF+ F+ Y+ + + + +++ A
Sbjct: 5742 RNVRDIGRFHSS-FLQELQQCDT-DDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTA 5799
Query: 1391 -GTFFDEIQQRHGLANSISS--------YLIKPVQRITKYQLLLKELLTCCEEGKGE--- 1438
F+ + + LA S YL +PV+R+ +YQ LLKEL+ +
Sbjct: 5800 IQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNRQNCAL 5859
Query: 1439 LKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIR---KGRE 1495
L+ V+ ++P++A + +HVS++E + L GE I Q F VW+ R KG
Sbjct: 5860 LEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMPWKGHN 5919
Query: 1496 RHLFLFEISLVFSKEIKDSSGHT-KYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSS 1554
RH+FLF LV K +DS T YV++N + S + + + VEGD F +W R S
Sbjct: 5920 RHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQER-EDS 5978
Query: 1555 DNKTVLKASNIETKQEWIKNIREVIQERI 1583
K +L+A K W+K I IQ+R+
Sbjct: 5979 VRKYLLQARTAIIKSSWVKEICG-IQQRL 6006
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 128 bits (322), Expect = 4e-29
Identities = 95/317 (29%), Positives = 163/317 (51%), Gaps = 36/317 (11%)
Query: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
++ E+L+TE+ YV+DL +E YL + ++P G + +FGNIQ+IY F++ +
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYL-DCIRDQTKLPLGT-EERSALFGNIQDIYHFNSEL- 173
Query: 1345 LKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQ 1399
L++LE E P + CFV+ +++F +Y YC N P S ++ E FF E Q+
Sbjct: 174 LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE 233
Query: 1400 RHGLANSISSYLIKPVQRITKYQLLLKEL---LTCCEEGKGELKDGLEVMLSVPKKAND- 1455
+ + SYL+KPVQRI KY LLL E+ L EG + D ++ M V ND
Sbjct: 234 TLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293
Query: 1456 ------AMHVSMLEGFDEN-----LDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEIS 1504
A+ + ++ N L GEL+L+ F++ K+ ER LFLF+
Sbjct: 294 KRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKN------ERTLFLFDKL 347
Query: 1505 LVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASN 1564
L+ +K+ D+ + YK +L L + E + +P F+++ + P + ++A +
Sbjct: 348 LLITKKRDDT-----FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH--TVQAKS 400
Query: 1565 IETKQEWIKNIREVIQE 1581
+ K+ W+ +++ +I E
Sbjct: 401 QQDKRLWVLHLKRLILE 417
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 112 bits (280), Expect = 3e-24
Identities = 101/327 (30%), Positives = 153/327 (46%), Gaps = 46/327 (14%)
Query: 1283 EFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILN----KEHIIFGNIQEIYD 1338
E + E+++TE+AYVRDL +E YL + G G+L + +F NI++IY+
Sbjct: 104 ERVAREIVETERAYVRDLRSIVEDYLGPLLDG------GVLGLSVEQVGTLFANIEDIYE 157
Query: 1339 FHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTF 1393
F + + L++LE + CFV ++ F +Y YC N P S L+ E A +
Sbjct: 158 FSSEL-LEDLENSSSAG-GIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALW 215
Query: 1394 FDE--IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE-----LKDGLEVM 1446
E Q RH L + S+L+KPVQRI KY LLL+EL EG G +++ + M
Sbjct: 216 LQERQAQLRHSLP--LQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSM 273
Query: 1447 LSVPKKANDAM----HVSMLEGFDE--------NLDVQGELILQDAFQVWDPKSLIRKGR 1494
+V ND H + L+ L GEL+L+ AF+ +G
Sbjct: 274 TAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGG 333
Query: 1495 ERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSS 1554
ER LFLF L+ +K +Y YK + L V+E DP F + P
Sbjct: 334 ERLLFLFSRMLLVAKR-----RGLEYTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK- 386
Query: 1555 DNKTVLKASNIETKQEWIKNIREVIQE 1581
++ +L+A N E K+ WI ++ + E
Sbjct: 387 -HRHLLQAKNQEEKRLWIHCLQRLFFE 412
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 105 bits (262), Expect = 4e-22
Identities = 251/1344 (18%), Positives = 506/1344 (37%), Gaps = 192/1344 (14%)
Query: 285 LDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSY 344
+ +L+ + L Q+ R L +++ F +DA++ +WI + + G
Sbjct: 1208 IKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL--NTDNYGHDL 1265
Query: 345 QYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFA 404
LQ +H F + +N + A RL ++ +++ +++ T+L+Q W S
Sbjct: 1266 ASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLG 1325
Query: 405 AALDERSTILAMSAVFHQKAEQF---LSGVDAWCKMCSEGGLPSEMQDLELAIHHHQ--- 458
D+R L S + F +S ++ + S L ++ E + HQ
Sbjct: 1326 KRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
Query: 459 TLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANY-SKAVHQVLDVVHEVLHH 517
T + + Q G+ LL A +Y S + Q LD++ +
Sbjct: 1386 TEIDARAGTFQAFEQFGQQLL----------------AHGHYASPEIKQKLDILDQ---E 1426
Query: 518 QRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQ 577
+ LE W R++ L Q L+L +F +D +Q +W+ EAFL+ G SL AL
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAR-EAFLNTE-DKGDSLDSVEALI 1484
Query: 578 KRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDF-VRRVEQR 636
K+H+DF++ L A+QL G +I + R + + +E+R
Sbjct: 1485 KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
Query: 637 KLLLDMSV--SFHTHTKELWTWMEDLQKEMLEDVCAD--SVDAVQELIKQFQQQQTATLD 692
L + F E+ W+ + + ++ D ++ + + + F+ + A D
Sbjct: 1545 SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANAD 1604
Query: 693 ATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQV 752
VI G LI+ R A + +AR +A+++ + ++Q+ +
Sbjct: 1605 RIRGVIDMGNSLIE--RGACAGSEDAVKARLAALAD----------QWQFLVQKSAEKSQ 1652
Query: 753 QMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQ 812
+++E ++ I + F+ + EV A L D+ +DL L+
Sbjct: 1653 KLKEANKQQNFNTGI----KDFDFWLSEVEA---------LLASEDYG-KDLASVNNLLK 1698
Query: 813 RHTERKLAMNNMTFEVIQQGQDLHQ-YITEVQASGIELICEKDIDLAAQVQELLEFLHEK 871
+H ++++ H+ + ++ + L+ D +QV++ + ++ +
Sbjct: 1699 KH------------QLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGR 1745
Query: 872 QHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQR 931
+++ A +L + +L ++ WI+ + +L S L+ + L++
Sbjct: 1746 FQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRK 1804
Query: 932 EHEQFQLAIESLFHATSLQKTHQSALQ-VQQKAEVLLQAGHYDADAIRECAEKVALHWQQ 990
+H++ + + + H+ A+Q V + L + I++ + HW++
Sbjct: 1805 KHKRLEAELAA----------HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKE 1854
Query: 991 LMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIP 1050
L R + + S+ + + + ++E+E E W + L + + +
Sbjct: 1855 LKQLAAARGQRLEESLEYQQ-------FVANVEEE----EAWINEKMTLVASEDYGDTLA 1903
Query: 1051 LISKHLEQKEAFLKACTLARRNAEVFL----KYIHRNNVSMPSVASHTRGPEQQVKAILS 1106
I L++ EAF T+ + I +NN +++S +G +V +
Sbjct: 1904 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK 1963
Query: 1107 ELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEE 1166
QR K +LD+ ++ F A WI E E L T G
Sbjct: 1964 AAAQR-----------KAKLDENSAFLQFNWKADVVESWIGEK-ENSLKT-DDYGRDLSS 2010
Query: 1167 TQELLKEYGEFRVPAKQ-TKEKVKLLIQLADSFVEKGHI--------HATEIRKW----- 1212
Q LL + F + +E + + L D + H+ HA+ +++W
Sbjct: 2011 VQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLA 2070
Query: 1213 --------VTTVDKHYR---DFSLRMGKYRYSLEKALGVNT-EDNKDLELDIIPASLSDR 1260
+ H+R D L K KA N+ +N + +L S
Sbjct: 2071 NSAARKKKLLEAQSHFRKVEDLFLTFAK------KASAFNSWFENAEEDLTDPVRCNSLE 2124
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
E+K H+ SA+ +AEL ++ Y W +EE
Sbjct: 2125 EIKALREAHDAFRSSLSSAQADFNQLAEL----DRQIKSFRVASNPYTWFTMEALEE--- 2177
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
+ N+Q+I + L++ ++ ++ + + F A+ F ++ +
Sbjct: 2178 --------TWRNLQKIIK-ERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYL 2228
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
++E +GT +++ + Q I + LK++ +L
Sbjct: 2229 LDGSCMVEESGTLESQLEATK-----------RKHQEIRAMRSQLKKI--------EDLG 2269
Query: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
+E L + K + V + + +D+ LD G + + Q ++ E L
Sbjct: 2270 AAMEEALILDNKYTEHSTVGLAQQWDQ-LDQLGMRMQHNLEQQIQARNTTGVTEEA---L 2325
Query: 1501 FEISLVFSKEIKDSSG---HTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNK 1557
E S++F KD SG H ++ + L +L + E E DP A+ P+ D
Sbjct: 2326 KEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGH 2385
Query: 1558 TVLK---ASNIETKQEWIKNIREV 1578
L+ A I + E +K+ E+
Sbjct: 2386 VSLQEYMAFMISRETENVKSSEEI 2409
Score = 102 bits (253), Expect = 4e-21
Identities = 174/980 (17%), Positives = 376/980 (38%), Gaps = 117/980 (11%)
Query: 280 KITSLLDKLHSTRQHLHQMWH-------VRKLKLDQCFQLRLFEQDAEKMFDWISHNKEL 332
K+ + + RQ + +H +R+ KL+ ++ + F++DAE++ WI ++
Sbjct: 7 KVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI 66
Query: 333 FLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQI 392
+ + + Q L +H F I ++ + + GH+AS+ I+
Sbjct: 67 ASDENYKDPTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTR 123
Query: 393 STQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLEL 452
+L ++W+ + E+ L + QK Q+L + ++ ++L
Sbjct: 124 LMELHRQWELLLEKMREKGIKLLQA----QKLVQYLRECEDVMDWINDKEAIVTSEELGQ 179
Query: 453 AIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVH 512
+ H + L ++ + T+++ + + +V Q A + H +++
Sbjct: 180 DLEHVEVLQKKFEEFQTDMAAHEERVNEVNQ------------FAAKLIQEQHPEEELIK 227
Query: 513 ----EVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGK 568
EV +RL+ + R+ +L ++ F +DV + + WI+ + S G+
Sbjct: 228 TKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDD--FGR 285
Query: 569 SLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQD 628
L +AL ++H+ E L A++L Q+ +I L +
Sbjct: 286 DLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQ 345
Query: 629 FVRRVEQRKLLLDMSVS---FHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQ 685
+R L+ S F ++L +W+ +++ + D A V + L+ + Q+
Sbjct: 346 IRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQE 405
Query: 686 QQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQ 745
+ +DA + K ++ Q L +A H +S + L
Sbjct: 406 HK-GEIDAHEDSFKSADESGQALLAAG--------------------HYAS-DEVREKLT 443
Query: 746 QLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLT 805
L + + + EL+ R+ + + + L++F + T +V + LL N+ + L
Sbjct: 444 VLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLL---NEDLGDSLD 500
Query: 806 LAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDI---DLAAQVQ 862
E L++H + FE Q+ + IT + +LI D+A +
Sbjct: 501 SVEALLKKHED---------FEKSLSAQE--EKITALDEFATKLIQNNHYAMEDVATRRD 549
Query: 863 ELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASS 922
LL +++ L A + +L L+ + ++ W+ E M A+
Sbjct: 550 ALLS----RRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN--EKMKTATDEAYKD 603
Query: 923 LSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKA-EVLLQAGHYDADAIRECA 981
S + ++H+ F+ + + +QS + +KA + L+ HY D +
Sbjct: 604 PSNLQGKVQKHQAFEAELSA----------NQSRIDALEKAGQKLIDVNHYAKDEVAARM 653
Query: 982 EKVALHWQQLMLKME---DRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
+V W++L+ E +L+ N F + E + L +E D+ G+D
Sbjct: 654 NEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDY---GKDL 710
Query: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPE 1098
++L++K A L+A A ++ I +
Sbjct: 711 TNV------------QNLQKKHALLEADVAAHQDR------IDGITIQARQFQDAGHFDA 752
Query: 1099 QQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHT 1158
+ +K L+ R + +K++L + R + WI+E ++ T
Sbjct: 753 ENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP--IAAST 810
Query: 1159 STGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDK 1218
+ G+ Q LLK++ + + ++K + Q ++ VE+GH A +++ + +++
Sbjct: 811 NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQ 870
Query: 1219 HYRDFSLRMGKYRYSLEKAL 1238
+ + + R LE +L
Sbjct: 871 KWEALKAKASQRRQDLEDSL 890
Score = 100 bits (248), Expect = 2e-20
Identities = 163/772 (21%), Positives = 295/772 (38%), Gaps = 125/772 (16%)
Query: 513 EVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHR 572
E L+H L + + RK L + + + ++ ++ WI A S+ VG L +
Sbjct: 1070 EELYHS--LLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE--VGADLEQ 1125
Query: 573 ARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTG-------ECDPEEIY--------- 616
LQK+ DDF++ + + + + AE L G +E+Y
Sbjct: 1126 VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETD 1185
Query: 617 -------KAAR-------------HLEVRIQDFVRRVEQRKLLLDMS---VSFHTHTKEL 653
K+AR L R + + E+R LL + FH E
Sbjct: 1186 SKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADET 1245
Query: 654 WTWMEDLQKEMLEDVCADSVDAVQELIKQFQ--QQQTATLDATLNVIKEGEDLIQQLRSA 711
W+E+ + + D + +VQ L ++ + ++ A L +N
Sbjct: 1246 KEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVN--------------- 1290
Query: 712 PPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQL 771
SLGE +E + H S ++ +L+ A + + +RK KL L
Sbjct: 1291 --SLGETAERLIQS-------HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDL 1341
Query: 772 RIFEQYTIEVTAELDAWNEDLLRQM-NDFNTEDLTLAEQRLQRHTERKLAMNNM--TFEV 828
+ F + +L +W + + +D +D+T AE L+RH E + ++ TF+
Sbjct: 1342 QRF----LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Query: 829 IQQ-GQDL--HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKR 885
+Q GQ L H + + ++++ L+ L +++ +LE Q
Sbjct: 1398 FEQFGQQLLAHGHYA-----------------SPEIKQKLDILDQERADLEKAWVQRRMM 1440
Query: 886 LEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFH 945
L+QCL+L+ + +Q W+ E+ LN SL E L ++HE F AI
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTE-DKGDSLDSVEALIKKHEDFDKAI----- 1494
Query: 946 ATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNAS 1005
++Q+ +ALQ A+ L+ AGHY I +V W++L +M ++ + S
Sbjct: 1495 --NVQEEKIAALQA--FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGES 1550
Query: 1006 VAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKA 1065
+ S V + E W +KL A++ + P + QK +A
Sbjct: 1551 QTLQQFSRDVDEI-----------EAWIS--EKLQTASDESYKDPTNIQSKHQKHQAFEA 1597
Query: 1066 CTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRR 1125
A NA+ I N + A G E VKA L+ L + ++ K ++
Sbjct: 1598 ELHA--NADRIRGVIDMGNSLIERGA--CAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1653
Query: 1126 LDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTK 1185
L + + F K W+ E S G+ LLK++ +
Sbjct: 1654 LKEANKQQNFNTGIKDFDFWLSEVEALLAS--EDYGKDLASVNNLLKKHQLLEADISAHE 1711
Query: 1186 EKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKA 1237
+++K L ADS + ++++ T++ ++ R L ++
Sbjct: 1712 DRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNES 1763
Score = 94.4 bits (233), Expect = 8e-19
Identities = 207/1106 (18%), Positives = 393/1106 (35%), Gaps = 157/1106 (14%)
Query: 286 DKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQ 345
D L S R LH+ R+ +L F L+ F +D++++ W++ + T +Y+
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK------TATDEAYK 602
Query: 346 YALDLQ---TQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKS 402
+LQ +H F I+ + +L + HYA ++ ++ WK
Sbjct: 603 DPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
Query: 403 FAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYE 462
A + + I A Q+ + + ++ W EG L S+ +L +
Sbjct: 663 LLEATELKG-IKLREANQQQQFNRNVEDIELWLYEV-EGHLASDDYGKDLTNVQNLQKKH 720
Query: 463 QVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLE 522
+ +A QD + + R A K + L +E L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFD----AENIKKKQEALVARYEALKEPMVA- 775
Query: 523 SIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDD 582
RK +L L+L +DV+ WI ++ T GK L + L K+H
Sbjct: 776 -----RKQKLADSLRLQQLFRDVEDEETWIREKEP--IAASTNRGKDLIGVQNLLKKHQA 828
Query: 583 FEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDM 642
+ + + + + G E++ L + + + QR+ L+
Sbjct: 829 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED 888
Query: 643 SVS---FHTHTKELWTWMEDLQ----------------------KEMLEDVCA--DSVDA 675
S+ + E +WM + + + ++ D+ A S+ A
Sbjct: 889 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA 948
Query: 676 VQELIKQFQQQQTATLDAT----------------LNVIKEGEDLIQQLRSA-------- 711
++E + +QQ T D T V + D++ L S
Sbjct: 949 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE 1008
Query: 712 --------PPSLGEPSEARDSAVSNNKTPHSSSIS----HIESVLQQLDDA------QVQ 753
P + + + SA N SI+ I++ + +A Q
Sbjct: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ 1068
Query: 754 MEELFH-------ERKIKLD-------IFLQLRIFEQYTIEVTAELDAWN--------ED 791
+EEL+H +RK L+ +F + +Q+ E A L + E
Sbjct: 1069 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 792 LLRQMNDFNTEDLTLAEQRLQ--RHTERKLAMNNMTFEVIQQGQDLHQY------ITEVQ 843
L ++ +DF +DL E RL+ L + E +Q Q Y T+ +
Sbjct: 1129 LQKKFDDFQ-KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSK 1187
Query: 844 ASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVL 903
+ + A + E L+E+ L+ AE+ + L +++ + +
Sbjct: 1188 TASPWKSARLMVHTVATFNSIKE-LNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246
Query: 904 GWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKA 963
WI LN L+ + LQR+HE F+ + +L + + + A
Sbjct: 1247 EWIEEKNQALNTDNYG-HDLASVQALQRKHEGFERDLAALGDKVN---------SLGETA 1296
Query: 964 EVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLE 1023
E L+Q+ A+ ++E ++ W L + + R + S L+
Sbjct: 1297 ERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-----------HDLQRFL 1345
Query: 1024 QEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRN 1083
++R W G L + E+ +K + EA L+ R +
Sbjct: 1346 SDFRDLMSWINGIRGLVSSDEL-------AKDVTGAEALLERHQEHRTEIDARAGTFQAF 1398
Query: 1084 NVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQAL 1143
+ +H ++K L L Q + W ++ LDQC + +F R +QA
Sbjct: 1399 EQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAE 1458
Query: 1144 DWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGH 1203
+W+ E +L+T G++ + + L+K++ +F +EK+ L AD + GH
Sbjct: 1459 NWM-AAREAFLNTE-DKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGH 1516
Query: 1204 IHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVK 1263
+I V +R +M + R L ++ T ++D I A +S++
Sbjct: 1517 YAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGES---QTLQQFSRDVDEIEAWISEKLQT 1573
Query: 1264 LRDANHEVNEEKRKSARKKEFIMAEL 1289
D +++ + +K + AEL
Sbjct: 1574 ASDESYKDPTNIQSKHQKHQAFEAEL 1599
Score = 93.6 bits (231), Expect = 1e-18
Identities = 172/839 (20%), Positives = 315/839 (37%), Gaps = 103/839 (12%)
Query: 190 LEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKV--LKAPVEELDR 247
L+ F + L+S + ++ +++ E DV G+ L++ H + + ++ + ++
Sbjct: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Query: 248 EGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLD 307
GQ+LL A P+I LD L R L + W R++ LD
Sbjct: 1401 FGQQLL------------------AHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLD 1442
Query: 308 QCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVN 367
QC +L+LF +D E+ +W++ +E FL + + G S L +H F
Sbjct: 1443 QCLELQLFHRDCEQAENWMA-AREAFLNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEK 1500
Query: 368 INRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQF 427
I + + A +L AGHYA I ++ W+ A + E+ + L S Q +QF
Sbjct: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGES----QTLQQF 1556
Query: 428 LSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLS 487
VD E + ++Q + T + Q + + A D ++ +
Sbjct: 1557 SRDVDE-----IEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVID 1611
Query: 488 PGNS-ESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQ---HRKVRLHQRLQLCVFQQ 543
GNS A A AV L L WQ + Q+L+ QQ
Sbjct: 1612 MGNSLIERGACAGSEDAVKARL----------AALADQWQFLVQKSAEKSQKLKEANKQQ 1661
Query: 544 DVQ---QVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
+ + D+ + EA L+ GK L L K+H E L
Sbjct: 1662 NFNTGIKDFDFWLSEVEALLASE-DYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1720
Query: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKEL---WTWM 657
A+ L + D ++ + R Q R+ L+ S H +++ +W+
Sbjct: 1721 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWI 1780
Query: 658 EDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGE 717
++ + + + + VQ L K+ ++ L+A L E IQ + L +
Sbjct: 1781 KEKKLLVGSEDYGRDLTGVQNLRKKHKR-----LEAEL---AAHEPAIQGVLDTGKKLSD 1832
Query: 718 PSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQY 777
D+ + + I+ L Q + ++++L R +L+ L+ ++Q+
Sbjct: 1833 -----DNTIGKEE---------IQQRLAQFVEHWKELKQLAAARGQRLEESLE---YQQF 1875
Query: 778 TIEVTAELDAW-NEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLH 836
V E +AW NE + ++ + L + L++H E + +H
Sbjct: 1876 VANVEEE-EAWINEKMTLVASEDYGDTLAAIQGLLKKH------------EAFETDFTVH 1922
Query: 837 Q-YITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHL 895
+ + +V +G +LI +K+ + ++ L+ K +LE A Q +L++
Sbjct: 1923 KDRVNDVCTNGQDLI-KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1981
Query: 896 QAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQS 955
+ V WI E+ L LS + L + E F +++ +
Sbjct: 1982 NWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAF--------QQEG 2032
Query: 956 ALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDR-LKLVNASVAFYKTSE 1013
+ + LL A H + AI + W QL+ R KL+ A F K +
Sbjct: 2033 IANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2091
Score = 91.7 bits (226), Expect = 5e-18
Identities = 218/1201 (18%), Positives = 435/1201 (36%), Gaps = 162/1201 (13%)
Query: 190 LEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKV--LKAPVEELDR 247
L+ F L S + +++ ++ E DV G+ L+D H + K ++ + + D
Sbjct: 363 LQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADE 422
Query: 248 EGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLD 307
GQ LL G + K+T L ++ R L ++W +R+ + +
Sbjct: 423 SGQALLAA--------------GHYASDEVREKLTVLSEE----RAALLELWELRRQQYE 464
Query: 308 QCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVN 367
QC L+LF +D E++ +W+S + L + ++G S L +H F +
Sbjct: 465 QCMDLQLFYRDTEQVDNWMSKQEAFLL--NEDLGDSLDSVEALLKKHEDFEKSLSAQEEK 522
Query: 368 INRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMS---AVFHQKA 424
I + A++L + HYA + + L + R LA S F + +
Sbjct: 523 ITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDS 582
Query: 425 EQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQR 484
++ S V+ K ++ + +L+ + HQ +++ ++ +D L++
Sbjct: 583 DELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAFEAELSA--------NQSRIDALEK 633
Query: 485 PLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQD 544
+ L +Y+K +V ++EV+ ++L + + ++L + Q F ++
Sbjct: 634 A-----GQKLIDVNHYAK--DEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
Query: 545 VQQVLDWI-ENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQ 603
V+ + W+ E G + GK L + LQK+H E D + A Q
Sbjct: 687 VEDIELWLYEVEGHLASDDY---GKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743
Query: 604 LAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKEL---WTWMEDL 660
G D E I K L R + + RK L S+ +++ TW+ +
Sbjct: 744 FQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK 803
Query: 661 QKEMLEDVCADSVDAVQELIKQFQQQQT----------ATLDATLNVIKEGEDLIQQLRS 710
+ + VQ L+K+ Q Q A +++EG + +++
Sbjct: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863
Query: 711 APPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEE---LFHERKIKLDI 767
L + EA + S + S+ + ++A+ M E + D
Sbjct: 864 KLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESWMREKEPIVGSTDYGKDE 922
Query: 768 FLQLRIFEQYTIEVTAELDAWNEDL--LRQM-----------NDFNTEDLTLAEQRLQRH 814
+ +++ + ++L A+ + LR+ +D ++L LA Q
Sbjct: 923 DSAEALLKKHE-ALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEK 981
Query: 815 TERKLAMNNMTFEVIQQGQDLHQYITEV------------------QASGIELICEKDID 856
+ R++ M + + + EV Q++ E + E+
Sbjct: 982 SPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGS 1041
Query: 857 LAAQVQEL----------------LEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
+A + +++ ++ + E H L E+ LE+ + L E
Sbjct: 1042 IALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREAN 1101
Query: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIES----LFHATSLQKTHQSA 956
++ WI E+ L + V A L + E LQ++ + FQ +++ L + + +S
Sbjct: 1102 ELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
Query: 957 LQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKME-----DRLKLVNAS-VAFYK 1010
+ ++ + + Q Y E K A W+ L + + +K +N + +
Sbjct: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
Query: 1011 TSEQVCSVLESLE--QEYRRDED----WCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLK 1064
+E+ +L S Q + RD D W +++ H + + + E F +
Sbjct: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
Query: 1065 ACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKR 1124
+ R S P A + ++ S L +R ++ +K
Sbjct: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQ-------RKA 1333
Query: 1125 RLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQT 1184
+L F + + WI S + T E LL+ + E R
Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEA--LLERHQEHRTEIDAR 1391
Query: 1185 KEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALG----- 1239
+ Q + GH + EI++ + +D+ D + R L++ L
Sbjct: 1392 AGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFH 1451
Query: 1240 ----------------VNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKE 1283
+NTED D LD + A + E D + +N ++ K A +
Sbjct: 1452 RDCEQAENWMAAREAFLNTEDKGD-SLDSVEALIKKHE----DFDKAINVQEEKIAALQA 1506
Query: 1284 F 1284
F
Sbjct: 1507 F 1507
Score = 86.7 bits (213), Expect = 2e-16
Identities = 168/848 (19%), Positives = 336/848 (39%), Gaps = 116/848 (13%)
Query: 184 IELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLK--AP 241
+E L +++F A S + + + ++ ++ D + + L+ +H L + +
Sbjct: 886 LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSS 945
Query: 242 VEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSL-----LDKLHSTRQHLH 296
++ L + Q Q + +D +G+ + D+Q P+ ++ L L+ST +
Sbjct: 946 IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKD-- 1003
Query: 297 QMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNH 356
W ++ Q F + +K+ S ++E L+ I + Q +D QT+
Sbjct: 1004 --WWKVEVNDRQGFVPAAY---VKKLDPAQSASRENLLEEQGSIALR-QEQIDNQTR--- 1054
Query: 357 FAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLD--------QEW---KSFAA 405
+ + + + ++ + L E G +++ + Q+W K A
Sbjct: 1055 ITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 406 ALDERSTILAMSAVFHQKAEQFLSGVDA-WCKMCSEGGLPSEMQDLELAIHHHQTLYEQV 464
+E L V +K + F + A ++ + +++ L Q + +Q
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ- 1173
Query: 465 TQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQV--LDVVHEVLHHQRRLE 522
+ Y + +D + + SP S L VH V + + E+ R L+
Sbjct: 1174 -EVYGMMPRD-----ETDSKTASPWKSARLM--------VHTVATFNSIKELNERWRSLQ 1219
Query: 523 SIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDD 582
+ + R L ++ F +D + +WIE +A + + G L +ALQ++H+
Sbjct: 1220 QLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN--YGHDLASVQALQRKHEG 1277
Query: 583 FEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDM 642
FE + L E AE+L Q+ E++ + L +R +QRK L
Sbjct: 1278 FERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGD 1337
Query: 643 S---VSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIK 699
S F + ++L +W+ ++ + D A V + L+++ Q+ +T +DA +
Sbjct: 1338 SHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT-EIDARAGTFQ 1396
Query: 700 EGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFH 759
E QQL + H +S I+ L LD + +E+ +
Sbjct: 1397 AFEQFGQQLLA--------------------HGHYAS-PEIKQKLDILDQERADLEKAWV 1435
Query: 760 ERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTED----LTLAEQRLQRHT 815
+R++ LD L+L++F + E A E L NTED L E +++H
Sbjct: 1436 QRRMMLDQCLELQLFHR-DCEQAENWMAAREAFL------NTEDKGDSLDSVEALIKKHE 1488
Query: 816 ERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDI---DLAAQVQELLEFLHEKQ 872
+ A+N +Q+ + I +QA +LI D++++ E+L ++
Sbjct: 1489 DFDKAIN------VQE-----EKIAALQAFADQLIAAGHYAKGDISSRRNEVL----DRW 1533
Query: 873 HELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQRE 932
L+ + +L + L+ +V ++ WI E + AS S + +Q +
Sbjct: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWI--SEKLQTAS---DESYKDPTNIQSK 1588
Query: 933 HEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHY--DADAIRECAEKVALHWQQ 990
H++ Q A E+ HA + V L++ G DA++ +A WQ
Sbjct: 1589 HQKHQ-AFEAELHANA-----DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQF 1642
Query: 991 LMLKMEDR 998
L+ K ++
Sbjct: 1643 LVQKSAEK 1650
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 104 bits (259), Expect = 8e-22
Identities = 253/1349 (18%), Positives = 507/1349 (37%), Gaps = 197/1349 (14%)
Query: 285 LDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSY 344
+ +L+ + L Q+ R L +++ F +DA++ +WI + + G
Sbjct: 1208 IKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL--NTDNYGHDL 1265
Query: 345 QYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFA 404
LQ +H F + +N + A RL ++ +++ +++ T+L+Q W S
Sbjct: 1266 ASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLG 1325
Query: 405 AALDERSTILAMSAVFHQKAEQF---LSGVDAWCKMCSEGGLPSEMQDLELAIHHHQ--- 458
D+R L S + F +S ++ + S L ++ E + HQ
Sbjct: 1326 KRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
Query: 459 TLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANY-SKAVHQVLDVVHEVLHH 517
T + + Q G+ LL A +Y S + Q LD++ +
Sbjct: 1386 TEIDARAGTFQAFEQFGQQLL----------------AHGHYASPEIKQKLDILDQ---E 1426
Query: 518 QRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQ 577
+ LE W R++ L Q L+L +F +D +Q +W+ EAFL+ G SL AL
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAR-EAFLNTE-DKGDSLDSVEALI 1484
Query: 578 KRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDF-VRRVEQR 636
K+H+DF++ L A+QL G +I + R + + +E+R
Sbjct: 1485 KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
Query: 637 KLLLDMSV--SFHTHTKELWTWMEDLQKEMLEDVCADSVD-AVQELIKQFQQQQT----- 688
L + F E+ W+ + + ++ D + + +L+ + Q+ Q
Sbjct: 1545 SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAEL 1604
Query: 689 -ATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQL 747
A D VI G LI+ R A + +AR +A+++ + ++Q+
Sbjct: 1605 HANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALAD----------QWQFLVQKS 1652
Query: 748 DDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLA 807
+ +++E ++ I + F+ + EV A L D+ +DL
Sbjct: 1653 AEKSQKLKEANKQQNFNTGI----KDFDFWLSEVEA---------LLASEDYG-KDLASV 1698
Query: 808 EQRLQRHTERKLAMNNMTFEVIQQGQDLHQ-YITEVQASGIELICEKDIDLAAQVQELLE 866
L++H ++++ H+ + ++ + L+ D +QV++ +
Sbjct: 1699 NNLLKKH------------QLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRD 1745
Query: 867 FLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEA 926
++ + +++ A +L + +L ++ WI+ + +L S L+
Sbjct: 1746 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGV 1804
Query: 927 EQLQREHEQFQLAIESLFHATSLQKTHQSALQ-VQQKAEVLLQAGHYDADAIRECAEKVA 985
+ L+++H++ + + + H+ A+Q V + L + I++ +
Sbjct: 1805 QNLRKKHKRLEAELAA----------HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFV 1854
Query: 986 LHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEI 1045
HW++L R + + S+ + + + ++E+E E W + L + +
Sbjct: 1855 EHWKELKQLAAARGQRLEESLEYQQ-------FVANVEEE----EAWINEKMTLVASEDY 1903
Query: 1046 DHVIPLISKHLEQKEAFLKACTLARRNAEVFL----KYIHRNNVSMPSVASHTRGPEQQV 1101
+ I L++ EAF T+ + I +NN +++S +G +V
Sbjct: 1904 GDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKV 1963
Query: 1102 KAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTG 1161
+ QR K +LD+ ++ F A WI E E L T G
Sbjct: 1964 SDLEKAAAQR-----------KAKLDENSAFLQFNWKADVVESWIGEK-ENSLKT-DDYG 2010
Query: 1162 ETTEETQELLKEYGEFRVPAKQ-TKEKVKLLIQLADSFVEKGHI--------HATEIRKW 1212
Q LL + F + +E + + L D + H+ HA+ +++W
Sbjct: 2011 RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRW 2070
Query: 1213 -------------VTTVDKHYR---DFSLRMGKYRYSLEKALGVNT-EDNKDLELDIIPA 1255
+ H+R D L K KA N+ +N + +L
Sbjct: 2071 SQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK------KASAFNSWFENAEEDLTDPVR 2124
Query: 1256 SLSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGV 1315
S E+K H+ SA+ +AEL ++ Y W +
Sbjct: 2125 CNSLEEIKALREAHDAFRSSLSSAQADFNQLAEL----DRQIKSFRVASNPYTWFTMEAL 2180
Query: 1316 EEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTY 1375
EE + N+Q+I + L++ ++ ++ + + F A+ F ++
Sbjct: 2181 EE-----------TWRNLQKIIK-ERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQE 2228
Query: 1376 CKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG 1435
+ ++E +GT +++ + Q I + LK++
Sbjct: 2229 TRTYLLDGSCMVEESGTLESQLEATK-----------RKHQEIRAMRSQLKKI------- 2270
Query: 1436 KGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE 1495
+L +E L + K + V + + +D+ LD G + + Q ++ E
Sbjct: 2271 -EDLGAAMEEALILDNKYTEHSTVGLAQQWDQ-LDQLGMRMQHNLEQQIQARNTTGVTEE 2328
Query: 1496 RHLFLFEISLVFSKEIKDSSG---HTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTP 1552
L E S++F KD SG H ++ + L +L + E E DP A+ P
Sbjct: 2329 A---LKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDP 2385
Query: 1553 SSDNKTVLK---ASNIETKQEWIKNIREV 1578
+ D L+ A I + E +K+ E+
Sbjct: 2386 NRDGHVSLQEYMAFMISRETENVKSSEEI 2414
Score = 102 bits (253), Expect = 4e-21
Identities = 174/980 (17%), Positives = 376/980 (38%), Gaps = 117/980 (11%)
Query: 280 KITSLLDKLHSTRQHLHQMWH-------VRKLKLDQCFQLRLFEQDAEKMFDWISHNKEL 332
K+ + + RQ + +H +R+ KL+ ++ + F++DAE++ WI ++
Sbjct: 7 KVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI 66
Query: 333 FLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQI 392
+ + + Q L +H F I ++ + + GH+AS+ I+
Sbjct: 67 ASDENYKDPTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTR 123
Query: 393 STQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLEL 452
+L ++W+ + E+ L + QK Q+L + ++ ++L
Sbjct: 124 LMELHRQWELLLEKMREKGIKLLQA----QKLVQYLRECEDVMDWINDKEAIVTSEELGQ 179
Query: 453 AIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVH 512
+ H + L ++ + T+++ + + +V Q A + H +++
Sbjct: 180 DLEHVEVLQKKFEEFQTDMAAHEERVNEVNQ------------FAAKLIQEQHPEEELIK 227
Query: 513 ----EVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGK 568
EV +RL+ + R+ +L ++ F +DV + + WI+ + S G+
Sbjct: 228 TKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDD--FGR 285
Query: 569 SLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQD 628
L +AL ++H+ E L A++L Q+ +I L +
Sbjct: 286 DLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQ 345
Query: 629 FVRRVEQRKLLLDMSVS---FHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQ 685
+R L+ S F ++L +W+ +++ + D A V + L+ + Q+
Sbjct: 346 IRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQE 405
Query: 686 QQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQ 745
+ +DA + K ++ Q L +A H +S + L
Sbjct: 406 HK-GEIDAHEDSFKSADESGQALLAAG--------------------HYAS-DEVREKLT 443
Query: 746 QLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLT 805
L + + + EL+ R+ + + + L++F + T +V + LL N+ + L
Sbjct: 444 VLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLL---NEDLGDSLD 500
Query: 806 LAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDI---DLAAQVQ 862
E L++H + FE Q+ + IT + +LI D+A +
Sbjct: 501 SVEALLKKHED---------FEKSLSAQE--EKITALDEFATKLIQNNHYAMEDVATRRD 549
Query: 863 ELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASS 922
LL +++ L A + +L L+ + ++ W+ E M A+
Sbjct: 550 ALLS----RRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN--EKMKTATDEAYKD 603
Query: 923 LSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKA-EVLLQAGHYDADAIRECA 981
S + ++H+ F+ + + +QS + +KA + L+ HY D +
Sbjct: 604 PSNLQGKVQKHQAFEAELSA----------NQSRIDALEKAGQKLIDVNHYAKDEVAARM 653
Query: 982 EKVALHWQQLMLKME---DRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
+V W++L+ E +L+ N F + E + L +E D+ G+D
Sbjct: 654 NEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDY---GKDL 710
Query: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPE 1098
++L++K A L+A A ++ I +
Sbjct: 711 TNV------------QNLQKKHALLEADVAAHQDR------IDGITIQARQFQDAGHFDA 752
Query: 1099 QQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHT 1158
+ +K L+ R + +K++L + R + WI+E ++ T
Sbjct: 753 ENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP--IAAST 810
Query: 1159 STGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDK 1218
+ G+ Q LLK++ + + ++K + Q ++ VE+GH A +++ + +++
Sbjct: 811 NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQ 870
Query: 1219 HYRDFSLRMGKYRYSLEKAL 1238
+ + + R LE +L
Sbjct: 871 KWEALKAKASQRRQDLEDSL 890
Score = 100 bits (249), Expect = 1e-20
Identities = 167/781 (21%), Positives = 300/781 (38%), Gaps = 138/781 (17%)
Query: 513 EVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHR 572
E L+H L + + RK L + + + ++ ++ WI A S+ VG L +
Sbjct: 1070 EELYHS--LLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE--VGADLEQ 1125
Query: 573 ARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTG-------ECDPEEIY--------- 616
LQK+ DDF++ + + + + AE L G +E+Y
Sbjct: 1126 VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETD 1185
Query: 617 -------KAAR-------------HLEVRIQDFVRRVEQRKLLLDMS---VSFHTHTKEL 653
K+AR L R + + E+R LL + FH E
Sbjct: 1186 SKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADET 1245
Query: 654 WTWMEDLQKEMLEDVCADSVDAVQELIKQFQ--QQQTATLDATLNVIKEGEDLIQQLRSA 711
W+E+ + + D + +VQ L ++ + ++ A L +N
Sbjct: 1246 KEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVN--------------- 1290
Query: 712 PPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQL 771
SLGE +E + H S ++ +L+ A + + +RK KL L
Sbjct: 1291 --SLGETAERLIQS-------HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDL 1341
Query: 772 RIFEQYTIEVTAELDAWNEDLLRQM-NDFNTEDLTLAEQRLQRHTERKLAMNNM--TFEV 828
+ F + +L +W + + +D +D+T AE L+RH E + ++ TF+
Sbjct: 1342 QRF----LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Query: 829 IQQ-GQDL--HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKR 885
+Q GQ L H + + ++++ L+ L +++ +LE Q
Sbjct: 1398 FEQFGQQLLAHGHYA-----------------SPEIKQKLDILDQERADLEKAWVQRRMM 1440
Query: 886 LEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFH 945
L+QCL+L+ + +Q W+ E+ LN SL E L ++HE F AI
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTE-DKGDSLDSVEALIKKHEDFDKAI----- 1494
Query: 946 ATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNAS 1005
++Q+ +ALQ A+ L+ AGHY I +V W++L +M ++ + S
Sbjct: 1495 --NVQEEKIAALQA--FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGES 1550
Query: 1006 VAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIP-------LISKHLEQ 1058
+ S V + E W +KL A++ + P L+SKH +
Sbjct: 1551 QTLQQFSRDVDEI-----------EAWIS--EKLQTASDESYKDPTNIQLSKLLSKHQKH 1597
Query: 1059 K--EAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVL 1116
+ EA L A NA+ I N + A G E VKA L+ L + ++
Sbjct: 1598 QAFEAELHA------NADRIRGVIDMGNSLIERGA--CAGSEDAVKARLAALADQWQFLV 1649
Query: 1117 HFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGE 1176
K ++L + + F K W+ E S G+ LLK++
Sbjct: 1650 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLAS--EDYGKDLASVNNLLKKHQL 1707
Query: 1177 FRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEK 1236
++++K L ADS + ++++ T++ ++ R L +
Sbjct: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1767
Query: 1237 A 1237
+
Sbjct: 1768 S 1768
Score = 94.7 bits (234), Expect = 6e-19
Identities = 221/1174 (18%), Positives = 416/1174 (35%), Gaps = 164/1174 (13%)
Query: 286 DKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQ 345
D L S R LH+ R+ +L F L+ F +D++++ W++ + T +Y+
Sbjct: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK------TATDEAYK 602
Query: 346 YALDLQ---TQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKS 402
+LQ +H F I+ + +L + HYA ++ ++ WK
Sbjct: 603 DPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
Query: 403 FAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYE 462
A + + I A Q+ + + ++ W EG L S+ +L +
Sbjct: 663 LLEATELKG-IKLREANQQQQFNRNVEDIELWLYEV-EGHLASDDYGKDLTNVQNLQKKH 720
Query: 463 QVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLE 522
+ +A QD + + R A K + L +E L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFD----AENIKKKQEALVARYEALKEPMVA- 775
Query: 523 SIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDD 582
RK +L L+L +DV+ WI ++ T GK L + L K+H
Sbjct: 776 -----RKQKLADSLRLQQLFRDVEDEETWIREKEP--IAASTNRGKDLIGVQNLLKKHQA 828
Query: 583 FEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDM 642
+ + + + + G E++ L + + + QR+ L+
Sbjct: 829 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED 888
Query: 643 SVS---FHTHTKELWTWMEDLQ----------------------KEMLEDVCA--DSVDA 675
S+ + E +WM + + + ++ D+ A S+ A
Sbjct: 889 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA 948
Query: 676 VQELIKQFQQQQTATLDAT----------------LNVIKEGEDLIQQLRSA-------- 711
++E + +QQ T D T V + D++ L S
Sbjct: 949 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE 1008
Query: 712 --------PPSLGEPSEARDSAVSNNKTPHSSSIS----HIESVLQQLDDA------QVQ 753
P + + + SA N SI+ I++ + +A Q
Sbjct: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ 1068
Query: 754 MEELFH-------ERKIKLD-------IFLQLRIFEQYTIEVTAELDAWN--------ED 791
+EEL+H +RK L+ +F + +Q+ E A L + E
Sbjct: 1069 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 792 LLRQMNDFNTEDLTLAEQRLQ--RHTERKLAMNNMTFEVIQQGQDLHQY------ITEVQ 843
L ++ +DF +DL E RL+ L + E +Q Q Y T+ +
Sbjct: 1129 LQKKFDDFQ-KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSK 1187
Query: 844 ASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVL 903
+ + A + E L+E+ L+ AE+ + L +++ + +
Sbjct: 1188 TASPWKSARLMVHTVATFNSIKE-LNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246
Query: 904 GWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKA 963
WI LN L+ + LQR+HE F+ + +L + + + A
Sbjct: 1247 EWIEEKNQALNTDNYG-HDLASVQALQRKHEGFERDLAALGDKVN---------SLGETA 1296
Query: 964 EVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLE 1023
E L+Q+ A+ ++E ++ W L + + R + S L+
Sbjct: 1297 ERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-----------HDLQRFL 1345
Query: 1024 QEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRN 1083
++R W G L + E+ +K + EA L+ R +
Sbjct: 1346 SDFRDLMSWINGIRGLVSSDEL-------AKDVTGAEALLERHQEHRTEIDARAGTFQAF 1398
Query: 1084 NVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQAL 1143
+ +H ++K L L Q + W ++ LDQC + +F R +QA
Sbjct: 1399 EQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAE 1458
Query: 1144 DWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGH 1203
+W+ E +L+T G++ + + L+K++ +F +EK+ L AD + GH
Sbjct: 1459 NWM-AAREAFLNTE-DKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGH 1516
Query: 1204 IHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVK 1263
+I V +R +M + R L ++ T ++D I A +S+ K
Sbjct: 1517 YAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGES---QTLQQFSRDVDEIEAWISE---K 1570
Query: 1264 LRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPG-I 1322
L+ A+ E ++ K + Q +A+ +LH + + G I G
Sbjct: 1571 LQTASDESYKDPTNIQLSK---LLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGAC 1627
Query: 1323 LNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPE 1356
E + + + D + K EK ++L E
Sbjct: 1628 AGSEDAVKARLAALADQWQFLVQKSAEKSQKLKE 1661
Score = 91.7 bits (226), Expect = 5e-18
Identities = 218/1201 (18%), Positives = 435/1201 (36%), Gaps = 162/1201 (13%)
Query: 190 LEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKV--LKAPVEELDR 247
L+ F L S + +++ ++ E DV G+ L+D H + K ++ + + D
Sbjct: 363 LQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADE 422
Query: 248 EGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLD 307
GQ LL G + K+T L ++ R L ++W +R+ + +
Sbjct: 423 SGQALLAA--------------GHYASDEVREKLTVLSEE----RAALLELWELRRQQYE 464
Query: 308 QCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVN 367
QC L+LF +D E++ +W+S + L + ++G S L +H F +
Sbjct: 465 QCMDLQLFYRDTEQVDNWMSKQEAFLL--NEDLGDSLDSVEALLKKHEDFEKSLSAQEEK 522
Query: 368 INRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMS---AVFHQKA 424
I + A++L + HYA + + L + R LA S F + +
Sbjct: 523 ITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDS 582
Query: 425 EQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQR 484
++ S V+ K ++ + +L+ + HQ +++ ++ +D L++
Sbjct: 583 DELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAFEAELSA--------NQSRIDALEK 633
Query: 485 PLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQD 544
+ L +Y+K +V ++EV+ ++L + + ++L + Q F ++
Sbjct: 634 A-----GQKLIDVNHYAK--DEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
Query: 545 VQQVLDWI-ENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQ 603
V+ + W+ E G + GK L + LQK+H E D + A Q
Sbjct: 687 VEDIELWLYEVEGHLASDDY---GKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743
Query: 604 LAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKEL---WTWMEDL 660
G D E I K L R + + RK L S+ +++ TW+ +
Sbjct: 744 FQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK 803
Query: 661 QKEMLEDVCADSVDAVQELIKQFQQQQT----------ATLDATLNVIKEGEDLIQQLRS 710
+ + VQ L+K+ Q Q A +++EG + +++
Sbjct: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863
Query: 711 APPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEE---LFHERKIKLDI 767
L + EA + S + S+ + ++A+ M E + D
Sbjct: 864 KLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESWMREKEPIVGSTDYGKDE 922
Query: 768 FLQLRIFEQYTIEVTAELDAWNEDL--LRQM-----------NDFNTEDLTLAEQRLQRH 814
+ +++ + ++L A+ + LR+ +D ++L LA Q
Sbjct: 923 DSAEALLKKHE-ALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEK 981
Query: 815 TERKLAMNNMTFEVIQQGQDLHQYITEV------------------QASGIELICEKDID 856
+ R++ M + + + EV Q++ E + E+
Sbjct: 982 SPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGS 1041
Query: 857 LAAQVQEL----------------LEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
+A + +++ ++ + E H L E+ LE+ + L E
Sbjct: 1042 IALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREAN 1101
Query: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIES----LFHATSLQKTHQSA 956
++ WI E+ L + V A L + E LQ++ + FQ +++ L + + +S
Sbjct: 1102 ELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
Query: 957 LQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKME-----DRLKLVNAS-VAFYK 1010
+ ++ + + Q Y E K A W+ L + + +K +N + +
Sbjct: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
Query: 1011 TSEQVCSVLESLE--QEYRRDED----WCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLK 1064
+E+ +L S Q + RD D W +++ H + + + E F +
Sbjct: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
Query: 1065 ACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKR 1124
+ R S P A + ++ S L +R ++ +K
Sbjct: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQ-------RKA 1333
Query: 1125 RLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQT 1184
+L F + + WI S + T E LL+ + E R
Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEA--LLERHQEHRTEIDAR 1391
Query: 1185 KEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALG----- 1239
+ Q + GH + EI++ + +D+ D + R L++ L
Sbjct: 1392 AGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFH 1451
Query: 1240 ----------------VNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKE 1283
+NTED D LD + A + E D + +N ++ K A +
Sbjct: 1452 RDCEQAENWMAAREAFLNTEDKGD-SLDSVEALIKKHE----DFDKAINVQEEKIAALQA 1506
Query: 1284 F 1284
F
Sbjct: 1507 F 1507
Score = 83.2 bits (204), Expect = 2e-15
Identities = 164/848 (19%), Positives = 333/848 (39%), Gaps = 111/848 (13%)
Query: 184 IELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLK--AP 241
+E L +++F A S + + + ++ ++ D + + L+ +H L + +
Sbjct: 886 LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSS 945
Query: 242 VEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSL-----LDKLHSTRQHLH 296
++ L + Q Q + +D +G+ + D+Q P+ ++ L L+ST +
Sbjct: 946 IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKD-- 1003
Query: 297 QMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNH 356
W ++ Q F + +K+ S ++E L+ I + Q +D QT+
Sbjct: 1004 --WWKVEVNDRQGFVPAAY---VKKLDPAQSASRENLLEEQGSIALR-QEQIDNQTR--- 1054
Query: 357 FAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLD--------QEW---KSFAA 405
+ + + + ++ + L E G +++ + Q+W K A
Sbjct: 1055 ITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 406 ALDERSTILAMSAVFHQKAEQFLSGVDA-WCKMCSEGGLPSEMQDLELAIHHHQTLYEQV 464
+E L V +K + F + A ++ + +++ L Q + +Q
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ- 1173
Query: 465 TQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQV--LDVVHEVLHHQRRLE 522
+ Y + +D + + SP S L VH V + + E+ R L+
Sbjct: 1174 -EVYGMMPRD-----ETDSKTASPWKSARLM--------VHTVATFNSIKELNERWRSLQ 1219
Query: 523 SIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDD 582
+ + R L ++ F +D + +WIE +A + + G L +ALQ++H+
Sbjct: 1220 QLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN--YGHDLASVQALQRKHEG 1277
Query: 583 FEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDM 642
FE + L E AE+L Q+ E++ + L +R +QRK L
Sbjct: 1278 FERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGD 1337
Query: 643 S---VSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIK 699
S F + ++L +W+ ++ + D A V + L+++ Q+ +T +DA +
Sbjct: 1338 SHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT-EIDARAGTFQ 1396
Query: 700 EGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFH 759
E QQL + H +S I+ L LD + +E+ +
Sbjct: 1397 AFEQFGQQLLA--------------------HGHYAS-PEIKQKLDILDQERADLEKAWV 1435
Query: 760 ERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTED----LTLAEQRLQRHT 815
+R++ LD L+L++F + E A E L NTED L E +++H
Sbjct: 1436 QRRMMLDQCLELQLFHR-DCEQAENWMAAREAFL------NTEDKGDSLDSVEALIKKHE 1488
Query: 816 ERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDI---DLAAQVQELLEFLHEKQ 872
+ A+N +Q+ + I +QA +LI D++++ E+L ++
Sbjct: 1489 DFDKAIN------VQE-----EKIAALQAFADQLIAAGHYAKGDISSRRNEVL----DRW 1533
Query: 873 HELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQRE 932
L+ + +L + L+ +V ++ WI + + + +L +
Sbjct: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
Query: 933 HEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHY--DADAIRECAEKVALHWQQ 990
H++ Q A E+ HA + V L++ G DA++ +A WQ
Sbjct: 1594 HQKHQ-AFEAELHANA-----DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQF 1647
Query: 991 LMLKMEDR 998
L+ K ++
Sbjct: 1648 LVQKSAEK 1655
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 102 bits (254), Expect = 3e-21
Identities = 85/322 (26%), Positives = 152/322 (47%), Gaps = 28/322 (8%)
Query: 1274 EKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNI 1333
E+++S ++ +++EL+ E+ YV L E + E+T + L+
Sbjct: 1078 ERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSAR------- 1130
Query: 1334 QEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTF 1393
+ + FH FL+EL+ P +G CF+ D+F +Y Y K++ LE+
Sbjct: 1131 ERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHK-----LENGLAA 1185
Query: 1394 FDEIQQRHGLANS-ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD-------GLEV 1445
+ + A + L +P++++T+Y LL+ELL E EL +++
Sbjct: 1186 LSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELL---REAGPELSSECRALGAAVQL 1242
Query: 1446 MLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISL 1505
+ + D + V + G + +L QG+L+ +D F V RK RH+FLFE L
Sbjct: 1243 LREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTV----ICGRKKCLRHVFLFEHLL 1298
Query: 1506 VFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNI 1565
+FSK G +VYK T+++G+TE++ F LW R + + T L+A++
Sbjct: 1299 LFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYT-LQATSP 1357
Query: 1566 ETKQEWIKNIREVIQERIIHLK 1587
E K +W +I +++ + H K
Sbjct: 1358 EIKLKWTSSIAQLLWRQAAHNK 1379
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 96.7 bits (239), Expect = 2e-19
Identities = 257/1268 (20%), Positives = 454/1268 (35%), Gaps = 246/1268 (19%)
Query: 191 EEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQ 250
+ F + LL E +Q L KE VDV ++RL+ EH L +EE+ +
Sbjct: 1070 QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDL--------LEEIHLWQE 1121
Query: 251 RLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCF 310
RL Q S + +C P S + + + L L Q L +W R+ L +
Sbjct: 1122 RLQQLDAQSQPMAALDC-PDSQE-------VPNTLRVLGQQGQELKVLWEQRQQWLQEGL 1173
Query: 311 QLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINR 370
+L+ F ++ + F N + +L +G + AL L QH F
Sbjct: 1174 ELQKFGREVDG-FTATCANHQAWLHL-DNLGEDVREALSLLQQHREFGRLLSTLGPRAEA 1231
Query: 371 IMSVASRLSE----AGHYASQQIKQISTQLD-------------------QEWKSFAAAL 407
+ + +L + A H +Q++ I Q QEWK A L
Sbjct: 1232 LRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL 1291
Query: 408 ----DERSTILA-----------MSAVFHQKAEQFLSGVDAWCKMCSEGG------LPSE 446
+E+ + A + H+ AE L + + G P
Sbjct: 1292 MQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCG 1351
Query: 447 MQDLELAIHHHQTLYEQVTQAYTEVS----------------QDGKALLDVLQRPLSPGN 490
+D++ + ++ +E + + TE QD K L+ L+ L
Sbjct: 1352 QEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSE 1411
Query: 491 SESLTATANYSKAVHQVLD-------------------------VVHEVLHHQRRLESIW 525
+ ++ + HQ L+ ++ E H RRLE +
Sbjct: 1412 TGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQ 1471
Query: 526 QH---RKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDD 582
H R ++L ++L F L W+ H T + L+ A++L ++H +
Sbjct: 1472 GHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPH--GSPTSYTECLNGAQSLHRKHKE 1529
Query: 583 FEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDM 642
+ + ++L + LA +G + I + + LE + R E R L
Sbjct: 1530 LQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQ 1589
Query: 643 SVSFHTH---TKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQ--QQQTA-------T 690
+V+F + EL W+E+ + + A LI + Q Q++ A
Sbjct: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
Query: 691 LDATLNV-----IKEGEDLIQQ-LRSAPPSLGEPSEARDSAVSNNKTPHS--SSISHIES 742
LD T + E + ++Q+ LR +L E + RD + H ++
Sbjct: 1650 LDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQG 1709
Query: 743 VLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDA----WNEDLL----- 793
L A E L + + L + + F Q+ +E+ ++ A E LL
Sbjct: 1710 WLASQKQAAKGGESLGEDPEHALHLCTKFAKF-QHQVEMGSQRVAACRLLAESLLERGHS 1768
Query: 794 ------RQMNDFNTE-----DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQD-------- 834
++ D T +LT A R TE L ++ EV+ Q Q+
Sbjct: 1769 AGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNN 1828
Query: 835 -------------LHQYITEVQASGIELICEKDIDLAAQVQEL-----LEFLHEKQHE-- 874
HQ + E + G E ++ ++ A +VQ+L + ++Q
Sbjct: 1829 VARDLCGLEAQLRSHQGL-ERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVT 1887
Query: 875 -----LELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQL 929
L+ EQ +LE+ L + V+ W L + S +L
Sbjct: 1888 QAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKL 1947
Query: 930 QREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAG------HYDADAIRECAEK 983
H+ + +E + +K Q A Q+ Q+A LL AG + A+++ ++
Sbjct: 1948 S-AHQWLRAELE------AREKLWQQATQLGQQA--LLAAGTPTKEVQEELRALQDQRDQ 1998
Query: 984 VALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAA 1043
V W + ++RL+ F + ++ +L + E + LG +
Sbjct: 1999 VYQTW----ARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLK--------TSALGSSV 2046
Query: 1044 EIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKA 1103
E V LI KH E FLK T A+ E L+ + P V
Sbjct: 2047 E--EVEQLIRKH----EVFLKVLT-AQDKKEAALRE-RLKTLRRPRVRDR---------- 2088
Query: 1104 ILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGET 1163
L LLQR RV + L F ++A QA DWIQ + L G+
Sbjct: 2089 -LPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQ-QLKEPVPPGDL 2146
Query: 1164 TEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDF 1223
++ + LLK + F + +E + + + ++ + + H A E+ + + + KH+ D
Sbjct: 2147 RDKLKPLLK-HQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDL 2205
Query: 1224 SLRMGKYRYSLEKALGVNTEDNKDL-----ELDIIPASLSDREVKLR--DANHEVNEEKR 1276
M G ED ++ +D+ A + ++EVK+ D ++ +
Sbjct: 2206 RQAMA--------LRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
Query: 1277 KSARKKEF 1284
R +EF
Sbjct: 2258 LRRRLREF 2265
Score = 76.6 bits (187), Expect = 2e-13
Identities = 203/1055 (19%), Positives = 388/1055 (36%), Gaps = 182/1055 (17%)
Query: 285 LDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSY 344
L L R ++Q W ++ +L Q +LF ++ ++ + ++ +E+ L++ + +G S
Sbjct: 1989 LRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAA-QEVSLKT-SALGSSV 2046
Query: 345 QYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFA 404
+ L +H F + + A + ++ RL + I Q K A
Sbjct: 2047 EEVEQLIRKHEVF-LKVLTA--QDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELA 2103
Query: 405 AALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQV 464
+ + A F Q A Q + AW + E P +++D + HQ +V
Sbjct: 2104 ESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEV 2163
Query: 465 T---QAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRL 521
+ T V++ G+ALL A +V + + H L
Sbjct: 2164 QAHEEVMTSVAKKGEALL------------------AQSHPRAGEVSQRLQGLRKHWEDL 2205
Query: 522 ESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTG-VGKSLHRARALQKRH 580
R L R F Q V WI+ E + + G +G+ L L++R
Sbjct: 2206 RQAMALRGQELEDRRNFLEFLQRVDLAEAWIQ---EKEVKMNVGDLGQDLEHCLQLRRRL 2262
Query: 581 DDFEEVAQNTYTNADKLLEAAEQLA-QTGECDPEE---IYKAARHLEVRIQDFVRRVEQR 636
+F + T D + + L+ Q DPEE I + L R F + +
Sbjct: 2263 REFRGNSAGD-TVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRY 2321
Query: 637 KLLLDMSVSFHTHTKELWTWMEDLQ-KEMLEDV--CADSVDAVQELIKQFQQQQTATLDA 693
+ L+ ++ H ++EL + +Q KE L C +++VQ L+++ ++ +
Sbjct: 2322 QQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPI 2381
Query: 694 TLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQ-- 751
V + E + +L P R V+ + S L L AQ
Sbjct: 2382 QAQV-ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKL 2440
Query: 752 --VQMEELFHERKIKLDIFLQ---------LRIFEQYTIEVTAELDAWNEDL-------- 792
+ E L ++++ + R+ E++ E AELD+W + +
Sbjct: 2441 QAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQ-ECKAELDSWTDSISLARSTGQ 2499
Query: 793 ------------LRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
+RQ+ ++L+ E Q H + +QQ +L +++
Sbjct: 2500 QLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQ-----------LQQALELQLFLS 2548
Query: 841 EVQASGIELICEKDIDLAAQ--------------VQELLEFLHEKQ----HELELNAEQT 882
V+ +C K+ LA++ ++LE+ E Q LE A
Sbjct: 2549 SVEKME-RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGL 2607
Query: 883 HK--------------------------------RLEQCLQLRHLQAEVKQVLGWIRNGE 910
H+ RLE+ QL+ + ++V W+R
Sbjct: 2608 HQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKN 2667
Query: 911 SM-LNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQA 969
+ L L++ + L QLQ++ + FQ +++ H ++Q++ + LLQ
Sbjct: 2668 LVALEEGLLDTAMLPA--QLQKQ-QNFQAELDASMHQQQ---------ELQREGQRLLQG 2715
Query: 970 GHYDADAIRECAEKVALHWQQLMLKMEDRL-KLVNASVAFY--KTSEQVCSVLESLEQEY 1026
GH ++AI+E E++ W +L + ++ KL A A ++ E++ + LE +E E
Sbjct: 2716 GHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVEL 2775
Query: 1027 RRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFL----KYIHR 1082
R A + +P + + L + A R AE L ++
Sbjct: 2776 R--------------APTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE 2821
Query: 1083 NNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQA 1142
+ V R Q+ K++ L +R L+ R L + F R A +
Sbjct: 2822 GHCLAQDVEEQARRLLQRFKSLREPLQERRT------ALEARSL-----LLKFFRDADEE 2870
Query: 1143 LDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKG 1202
+ W+QE + L+ G++ + L +++ + ++++ V+ G
Sbjct: 2871 MAWVQE--KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAG 2928
Query: 1203 HIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKA 1237
H A E+ V ++K + R L++A
Sbjct: 2929 HFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQA 2963
Score = 71.6 bits (174), Expect = 6e-12
Identities = 173/921 (18%), Positives = 347/921 (37%), Gaps = 138/921 (14%)
Query: 183 WIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPV 242
W E +L L++ + LS +E ++ L KE + EG L D ++ + K +
Sbjct: 2530 WQEHQLQLQQALELQL-FLSSVEKMERWLCSKEDSLASEG---LWDPLAPMEPLLWKHKM 2585
Query: 243 EELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVR 302
E D E Q I + + G + QS + + ++L + ++ L + R
Sbjct: 2586 LEWDLEVQA--GKISALEATARGLHQGGHPEAQSALGRCQAMLLR----KEALFRQAGTR 2639
Query: 303 KLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSM 362
+ +L++ QL+ F QD++++ W+ + L+ G+ L Q Q +
Sbjct: 2640 RHRLEELRQLQAFLQDSQEVAAWLREKNLVALEE----GLLDTAMLPAQLQKQQNFQAEL 2695
Query: 363 NAYVNINR-IMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFH 421
+A ++ + + RL + GH AS+ I++ +L W ++ L A
Sbjct: 2696 DASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKL-QKACEA 2754
Query: 422 QKAEQFLSGVDAWCKMCS-EGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
+ + + ++ W + E P+ Q L + ++ A + ++ +ALL
Sbjct: 2755 LRLRRSMEELENWLEPIEVELRAPTVGQALP-GVGELLGTQRELEAAVDKKARQAEALLG 2813
Query: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
Q + G+ V + +L + L Q R+ L R L
Sbjct: 2814 QAQAFVREGHC-----------LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
Query: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
F +D + + W++ + L+ G+SL R LQ++H + E + +L
Sbjct: 2863 FFRDADEEMAWVQE--KLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGT 2920
Query: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDM---SVSFHTHTKELWTWM 657
+L Q G E+ + LE + +R+LLL + F T E +W+
Sbjct: 2921 GYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWL 2980
Query: 658 EDLQKEMLEDVCADSVDAVQELIKQFQ----------------QQQTATLDATLNVIKEG 701
+ + + S +A Q L+++ + QQ A L++ N E
Sbjct: 2981 AERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKN--PES 3038
Query: 702 EDLIQQL---RSAPPSLGEPSEARDSAVSNNKTPH---------------SSSISHIESV 743
++ QL R A L +EAR + H ++ + +
Sbjct: 3039 PKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDY 3098
Query: 744 LQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELD----------------- 786
Q L+ +V +EE F + ++ Q +++ + T E
Sbjct: 3099 GQDLEGVKV-LEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
Query: 787 AWNEDLLRQMNDFNTEDLTLAEQ---------RLQRHTERKLAM-----NNMTFEVIQQG 832
AW + L Q TE+L A + LQ + K A+ + ++
Sbjct: 3158 AW--ERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTL 3215
Query: 833 QDLHQYITEVQASGIELICEKDIDLAAQVQEL-------LEFLHEKQHELELNAEQTHKR 885
Q H+ + E + +E + A ++ +L L + E L+ A++ +
Sbjct: 3216 QQQHRRL-ERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQW 3274
Query: 886 LEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFH 945
L Q Q +++L W + + + ++ + A ++ AEQL +HE+
Sbjct: 3275 LAQAAQGHAFLGRCQELLAWAQERQELASSEEL-AEDVAGAEQLLGQHEEL--------- 3324
Query: 946 ATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKV-----------ALHWQQL--- 991
+++ A ++Q+ + L+ H+ + + EC +++ AL WQ+
Sbjct: 3325 GQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAES 3384
Query: 992 --MLKMEDRLKLVNASVAFYK 1010
+ K+ RL+ A +A ++
Sbjct: 3385 WGLQKLRQRLEQAEAWLACWE 3405
Score = 69.7 bits (169), Expect = 2e-11
Identities = 165/752 (21%), Positives = 299/752 (39%), Gaps = 107/752 (14%)
Query: 235 KKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQH 294
++ L+A V++ R+ + LL G + G Q + + LL + S R+
Sbjct: 2794 QRELEAAVDKKARQAEALL-------GQAQAFVREGHCLAQDVEEQARRLLQRFKSLREP 2846
Query: 295 LHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQH 354
L + R+ L+ L F +DA++ W+ ++L L + + G S LQ QH
Sbjct: 2847 LQE----RRTALEARSLLLKFFRDADEEMAWVQ--EKLPLAAAQDYGQSLSAVRHLQEQH 2900
Query: 355 NHFAMNSMNAYVNINRI-MSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTI 413
+ + M+++ + R+ + +L +AGH+A+ ++ QL++ A R +
Sbjct: 2901 QNLE-SEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLL 2959
Query: 414 LAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQV------TQA 467
L + Q+A+QFL+ + +E G + +D+ + Q L ++ +A
Sbjct: 2960 LQQA----QEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
Query: 468 YT---EVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESI 524
++ E Q ALL+ + P SP K + Q+ V RR E+
Sbjct: 3016 FSPRIERLQQTAALLESRKNPESP-------------KVLAQLQAVREAHAELLRRAEA- 3061
Query: 525 WQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFE 584
R L ++LQL +++ + W+ +A ++ G+ L + L+++ D F
Sbjct: 3062 ---RGHGLQEQLQLHQLERETLLLDAWLTT--KAATAESQDYGQDLEGVKVLEEKFDAFR 3116
Query: 585 EVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQ------RKL 638
+ Q+ + A +LA T E Y + RI+ R++Q L
Sbjct: 3117 KEVQSL---GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENL 3173
Query: 639 LLDMSV-SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNV 697
V SF EL M++ M + S+ +V+ L QQQ L+ L
Sbjct: 3174 AAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTL-----QQQHRRLERELEA 3228
Query: 698 IKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEEL 757
+ E + +L++ LG+ A L ++ +A ++
Sbjct: 3229 M---EKEVARLQTEACRLGQLHPAAPGG------------------LAKVQEAWATLQAK 3267
Query: 758 FHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLR-QMNDFNTEDLTLAEQRLQRHTE 816
ER L Q F + EL AW ++ ++ ED+ AEQ L +H E
Sbjct: 3268 AQERGQWLAQAAQGHAF----LGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEE 3323
Query: 817 RKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELE 876
+ E Q QDL Q G +L+ + ++A+V E L+ L + ELE
Sbjct: 3324 ----LGQEIRECRLQAQDLRQ-------EGQQLV-DNSHFMSAEVTECLQELEGRLQELE 3371
Query: 877 LNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQF 936
+R + L+ L+ ++Q W+ E +L S+S+ E L H+
Sbjct: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLL-LKPDYGHSVSDVELLLHRHQD- 3429
Query: 937 QLAIESLFHATSLQKTHQSALQVQQKAEVLLQ 968
+E L A + +++Q E+LLQ
Sbjct: 3430 ---LEKLLAAQEEKFAQMQKTEMEQ--ELLLQ 3456
Score = 65.9 bits (159), Expect = 3e-10
Identities = 190/1076 (17%), Positives = 394/1076 (36%), Gaps = 142/1076 (13%)
Query: 184 IELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKK--VLKAP 241
++ ++ +++F L +E+ + +++ +++ D + RLI++H L+++ + +
Sbjct: 1587 LQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSS 1646
Query: 242 VEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHV 301
+EELD+ Q L P + Q +V ++L + L ++
Sbjct: 1647 MEELDQTAQTLTG--------------PEVPEQQRVVQ------ERLREQLRALQELAAT 1686
Query: 302 RKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNS 361
R +L+ +L F ++AE + W++ K+ + +G ++AL L T+ F
Sbjct: 1687 RDRELEGTLRLHEFLREAEDLQGWLASQKQA-AKGGESLGEDPEHALHLCTKFAKFQHQV 1745
Query: 362 MNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAV-- 419
+ +A L E GH A ++Q L W R L +
Sbjct: 1746 EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTL 1805
Query: 420 -FHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKAL 478
H+ + L+ V + ++ LE + HQ L ++ ++ + L
Sbjct: 1806 RVHRDLLEVLTQVQEKATSL-PNNVARDLCGLEAQLRSHQGLERELVGTERQLQE----L 1860
Query: 479 LDVLQR--PLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRL 536
L+ R L PG A +AV Q V+ QRR+E R+ +L +
Sbjct: 1861 LETAGRVQKLCPG--PQAHAVQQRQQAVTQAWAVL------QRRME----QRRAQLERAR 1908
Query: 537 QLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADK 596
L F+ V+ W V + L + Q+ +++ + + A+
Sbjct: 1909 LLARFRTAVRDYASWAAR-----------VRQDLQVEESSQEPSSGPLKLSAHQWLRAE- 1956
Query: 597 LLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTW 656
LEA E+L Q ++ AA +Q+ +R ++ ++ + T ++
Sbjct: 1957 -LEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQR-----DQVYQTWARK---- 2006
Query: 657 MEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLG 716
E LQ E E + ++E++ Q+ + A + ++E E LI++ L
Sbjct: 2007 QERLQAEQQEQLFLRECGRLEEILA--AQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
Query: 717 EPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQ 776
+ + KT + +L Q +++++EL R L L + F Q
Sbjct: 2065 AQDKKEAALRERLKTLRRPRVRDRLPILLQ---RRMRVKELAESRGHALHASLLMASFTQ 2121
Query: 777 YTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLH 836
+ + AW + L + + D + K + + FE Q +
Sbjct: 2122 AATQAEDWIQAWAQQLKEPVPPGDLRD------------KLKPLLKHQAFEAEVQAHE-- 2167
Query: 837 QYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQ 896
+ +T V G L+ + A +V + L+ L + +L + LE
Sbjct: 2168 EVMTSVAKKGEALLAQSH-PRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFL 2226
Query: 897 AEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSA 956
V WI+ E +N + L QL+R +F+ S T A
Sbjct: 2227 QRVDLAEAWIQEKEVKMNVGDL-GQDLEHCLQLRRRLREFR--------GNSAGDTVGDA 2277
Query: 957 LQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVC 1016
++ +++ LQ + D + ++ ++ R +L N +F+ +
Sbjct: 2278 C-IRSISDLSLQLKNRDPEEVKIICQR--------------RSQLNNRWASFHGNLLRYQ 2322
Query: 1017 SVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLAR------ 1070
LE G + + E+D+V +K +++KEA ++A +
Sbjct: 2323 QQLE-------------GALEIHVLSRELDNV----TKRIQEKEALIQALDCGKDLESVQ 2365
Query: 1071 ---RNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLD 1127
R E + +H + S+ Q+ L R+ V W + R
Sbjct: 2366 RLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQ 2425
Query: 1128 QCQQYVVFERSAKQALDWIQE--TGEFYLSTHTSTG---ETTEETQELLKEYGEFRVPAK 1182
+ ++ + A++ +QE L T + E + +L+E+ E +
Sbjct: 2426 KRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELD 2485
Query: 1183 QTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
+ + L + GH +++IR+ + +++ +++ L++AL
Sbjct: 2486 SWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQAL 2541
Score = 64.7 bits (156), Expect = 7e-10
Identities = 187/899 (20%), Positives = 342/899 (38%), Gaps = 135/899 (15%)
Query: 172 FDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHT 231
F G+L +++ +E L + ++ R+++ + ++ + D+E +RL+ +H
Sbjct: 2314 FHGNL-LRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHE 2372
Query: 232 QLKKKV--LKAPVEELDREGQRLLQCIRCSDGFSG-----RNCIPGSADFQSLVPKITSL 284
+L+++V ++A VE L+RE RL C R + G + +S K
Sbjct: 2373 ELEREVHPIQAQVESLEREVGRL--CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREA 2430
Query: 285 LDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSY 344
LD LH Q L M L Q + ++ A + L+ H E
Sbjct: 2431 LDALHQA-QKLQAMLQ-ELLVSAQRLRAQMDTSPAPRS----PVEARRMLEEHQEC---- 2480
Query: 345 QYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFA 404
+ LD T +I+ S +L AGH S I+Q+ L+QE S
Sbjct: 2481 KAELDSWTD-------------SISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE 2527
Query: 405 AALDERSTILAMSAVFHQKAEQFLSGVDAWCK-MCS-EGGLPSE-----MQDLELAIHHH 457
A E L + + + FLS V+ + +CS E L SE + +E + H
Sbjct: 2528 GAWQEHQLQLQQAL----ELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKH 2583
Query: 458 QTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHH 517
+ L + EV + L+ R L G A + Q + + E L
Sbjct: 2584 KMLEWDL-----EVQAGKISALEATARGLHQGGHPE----AQSALGRCQAMLLRKEALFR 2634
Query: 518 QRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQ 577
Q R+ RL + QL F QD Q+V W+ L + G+ + LQ
Sbjct: 2635 QAGT------RRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEE--GLLDTAMLPAQLQ 2686
Query: 578 KRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEV---RIQDFVRRVE 634
K+ +F+ + +L ++L Q G E I + L +QD ++
Sbjct: 2687 KQ-QNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKV 2745
Query: 635 QRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDAT 694
+ ++ +EL W+E ++ E+ ++ V EL+ Q++ A +D
Sbjct: 2746 AKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGT-QRELEAAVD-- 2802
Query: 695 LNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQM 754
++ R A LG+ A + + H + +E ++L +
Sbjct: 2803 -----------KKARQAEALLGQ-------AQAFVREGHCLA-QDVEEQARRLLQRFKSL 2843
Query: 755 EELFHERKIKLDI-FLQLRIFEQYTIEVTAELDAWNEDL--LRQMNDFNTEDLTLAEQRL 811
E ER+ L+ L L+ F E+ AW ++ L D+ + L+
Sbjct: 2844 REPLQERRTALEARSLLLKFFRDADEEM-----AWVQEKLPLAAAQDYG-QSLSAVRHLQ 2897
Query: 812 QRHTERKLAMNNMTFEVIQQGQDLHQYITE-VQASGIELICEKDI---DLAAQVQELLEF 867
++H + M++ H+ +T V +G +L+ ++AA+VQ+L
Sbjct: 2898 EQHQNLESEMSS------------HEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL--- 2942
Query: 868 LHEKQHELELNAEQTHKR--LEQCLQLRHLQAEVKQVLGW------IRNGESMLNASLVN 919
++ L AE +R L+Q + + E+ + W + + E M +++
Sbjct: 2943 ---EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEAT 2999
Query: 920 ASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQ--------SALQVQQKAEV-LLQAG 970
+ L E +R+ E F IE L +L ++ + + LQ ++A LL+
Sbjct: 3000 QALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRA 3059
Query: 971 HYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRD 1029
++E + L + L+L K A Y + VLE +R++
Sbjct: 3060 EARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKE 3118
Score = 63.2 bits (152), Expect = 2e-09
Identities = 186/936 (19%), Positives = 334/936 (35%), Gaps = 146/936 (15%)
Query: 470 EVSQDGKALLDVLQRPLSPGNS---ESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQ 526
E Q+ KA LD +S S + LTA +S + QVL + + L LE WQ
Sbjct: 2475 EEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSS---LEGAWQ 2531
Query: 527 HRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEV 586
+++L Q L+L +F V+++ W+ + ++ S+ G+ L L +H E
Sbjct: 2532 EHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE--GLWDPLAPMEPLLWKHKMLEWD 2589
Query: 587 AQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLD---MS 643
+ L A L Q G + + + + +R + R+ R+ L+
Sbjct: 2590 LEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQL 2649
Query: 644 VSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQ--FQQQQTATLDATLNVIKEG 701
+F ++E+ W+ + LE+ D+ +L KQ FQ + A++ + +EG
Sbjct: 2650 QAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREG 2709
Query: 702 EDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHER 761
+ L+Q A ++ E E + + ++ ++ + L + MEEL
Sbjct: 2710 QRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEAL-RLRRSMEEL---- 2764
Query: 762 KIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAM 821
E + + EL A Q L E
Sbjct: 2765 -------------ENWLEPIEVELRA-----------------PTVGQALPGVGELLGTQ 2794
Query: 822 NNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQ 881
+ V ++ + + + QA E C LA V+E L ++ L ++
Sbjct: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHC-----LAQDVEEQARRLLQRFKSLREPLQE 2849
Query: 882 THKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIE 941
LE L + + + W++ + L A+ SLS LQ +H+ +
Sbjct: 2850 RRTALEARSLLLKFFRDADEEMAWVQE-KLPLAAAQDYGQSLSAVRHLQEQHQNLE---- 2904
Query: 942 SLFHATSLQKTHQSALQ-VQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLK 1000
S +H++ + V L+QAGH+ A +VA QQL E +
Sbjct: 2905 ------SEMSSHEALTRVVLGTGYKLVQAGHF-------AAHEVAARVQQL----EKAMA 2947
Query: 1001 LVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKE 1060
+ A A + Q + E W R + + ++ H E +
Sbjct: 2948 HLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGH-------SAEATQ 3000
Query: 1061 AFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWT 1120
A L+ +R+ E F I R + + S +V A L + + +L
Sbjct: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAE 3060
Query: 1121 LKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVP 1180
+ L + Q ER W L+T +T E+ + Q+L
Sbjct: 3061 ARGHGLQEQLQLHQLERETLLLDAW--------LTTKAATAESQDYGQDL---------- 3102
Query: 1181 AKQTKEKVKLLIQLADSFVEK----GHIHATEIRKWVTTVDK-------HYRDFSLRMGK 1229
E VK+L + D+F ++ G +RK T+++ H + R+
Sbjct: 3103 -----EGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
Query: 1230 YRYSLEKALGVNTED----NKDLELDIIPASLSDRE------VKLRDANHEVN------E 1273
L++A+ TE+ ++ A L R +K D H ++ +
Sbjct: 3158 AWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQ 3217
Query: 1274 EKRKSARKKEFIMAEL--LQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNK------ 1325
+ R+ R+ E + E+ LQTE + LH L ++ + +
Sbjct: 3218 QHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQ 3277
Query: 1326 ---EHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDV 1358
H G QE+ + +EL E+L EDV
Sbjct: 3278 AAQGHAFLGRCQELLAWAQE--RQELASSEELAEDV 3311
Score = 58.2 bits (139), Expect = 7e-08
Identities = 145/785 (18%), Positives = 306/785 (38%), Gaps = 129/785 (16%)
Query: 387 QQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKA---EQFLSGVDAWCKMCSEGGL 443
++++ + Q DQ ++++A ER +F ++ E+ L+ + K + G
Sbjct: 1987 EELRALQDQRDQVYQTWARK-QERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALG-- 2043
Query: 444 PSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKA 503
S ++++E I H+ + +T A + + L L+RP
Sbjct: 2044 -SSVEEVEQLIRKHEVFLKVLT-AQDKKEAALRERLKTLRRP------------------ 2083
Query: 504 VHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKH 563
+V D + +L + R++ + + R LH L + F Q Q DWI+ + L +
Sbjct: 2084 --RVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQ-LKEP 2140
Query: 564 TGVG------KSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYK 617
G K L + +A + EEV + + LL A+ + GE + +
Sbjct: 2141 VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALL--AQSHPRAGEVS-QRLQG 2197
Query: 618 AARHLEVRIQDFVRR---VEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVD 674
+H E Q R +E R+ L+ F W+++ + +M ++
Sbjct: 2198 LRKHWEDLRQAMALRGQELEDRRNFLE----FLQRVDLAEAWIQEKEVKMNVGDLGQDLE 2253
Query: 675 AVQELIKQFQQQQTATLDATLN--VIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTP 732
+L ++ ++ + + T+ I+ DL QL++ P + R S ++N
Sbjct: 2254 HCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWAS 2313
Query: 733 HSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDL 792
++ + QQL+ A L++ + + VT + ++
Sbjct: 2314 FHGNLLRYQ---QQLEGA------------------LEIHVLSRELDNVTKRIQ--EKEA 2350
Query: 793 LRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIEL--I 850
L Q D +DL ++ L++H E + +++H +V++ E+ +
Sbjct: 2351 LIQALDCG-KDLESVQRLLRKHEELE--------------REVHPIQAQVESLEREVGRL 2395
Query: 851 CEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGE 910
C++ + A ++ + + E +L A++ + L+ Q + LQA ++++L +
Sbjct: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR 2455
Query: 911 SMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAG 970
+ ++ S S + EA ++ EH++ + ++S + SL ++ + LL AG
Sbjct: 2456 AQMDTSPAPRSPV-EARRMLEEHQECKAELDSWTDSISLARS---------TGQQLLTAG 2505
Query: 971 HYDADAIRECAEKVALH-------WQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLE 1023
H + IR+ + WQ+ L+++ L+L + K +CS +SL
Sbjct: 2506 HPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLA 2565
Query: 1024 QEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRN 1083
E G D L P + PL+ KH + + EV I
Sbjct: 2566 SE--------GLWDPLAP------MEPLLWKH-----------KMLEWDLEVQAGKISAL 2600
Query: 1084 NVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQAL 1143
+ + Q +L R+ + ++ RL++ +Q F + +++
Sbjct: 2601 EATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVA 2660
Query: 1144 DWIQE 1148
W++E
Sbjct: 2661 AWLRE 2665
Score = 53.1 bits (126), Expect = 2e-06
Identities = 133/697 (19%), Positives = 265/697 (38%), Gaps = 81/697 (11%)
Query: 269 PGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISH 328
PG A+ Q L ++ +L L ++ + Q R + + + F Q+++++ W +
Sbjct: 1030 PGYAESQPLQGQVETLQGLLKQVQEQVAQ----RARRQAETQARQSFLQESQQLLLW-AE 1084
Query: 329 NKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQ 388
+ + L+S E+ V A L +H + ++ + + ++ SQ+
Sbjct: 1085 SVQAQLRSK-EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQE 1143
Query: 389 IKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQ 448
+ L Q+ + ++R L + ++F VD + C+
Sbjct: 1144 VPNTLRVLGQQGQELKVLWEQRQQWLQEGL----ELQKFGREVDGFTATCAN-------- 1191
Query: 449 DLELAIHHHQTLYEQVTQAYTEVSQDGK--ALLDVLQRPLSPGNSESLTATANYSKAVHQ 506
A H L E V +A + + Q + LL L + + A H
Sbjct: 1192 --HQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
Query: 507 VLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGV 566
V + + + RL+ + R+ +L LQL ++QDV +++ W+E G ++ H
Sbjct: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKG--LMAAHEPS 1307
Query: 567 GKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRI 626
G + + L KRH+ E T + + L + +L C E+I + L +
Sbjct: 1308 GARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKW 1366
Query: 627 QDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQ-- 684
+ R++ +R ++LQ+ ++L++Q Q
Sbjct: 1367 EALNRKMTERG--------------------DELQQ----------AGQQEQLLRQLQDA 1396
Query: 685 QQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISH----I 740
++Q L+ L + G+DL R SE+R A K +S++H
Sbjct: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA---KMAALASMAHGMAAS 1453
Query: 741 ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRI-FEQYTIEVTAELDAWNEDLLRQMNDF 799
++L++ ++E L I+ + LQ + Q+ EL E +
Sbjct: 1454 PAILEETQKHLRRLELLQGHLAIR-GLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTS 1512
Query: 800 NTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAA 859
TE L A+ ++H E ++ + QGQ + V +SG L A
Sbjct: 1513 YTECLNGAQSLHRKHKELQVEVK------AHQGQ-----VQRVLSSGRSLAASGH-PQAQ 1560
Query: 860 QVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVN 919
+ E + L ELE E + L+Q + + +V ++ GW+ ++++
Sbjct: 1561 HIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS---R 1617
Query: 920 ASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSA 956
EA L+ ++ L E + +S+++ Q+A
Sbjct: 1618 DYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA 1654
Score = 45.8 bits (107), Expect = 3e-04
Identities = 33/156 (21%), Positives = 71/156 (45%), Gaps = 20/156 (12%)
Query: 182 EWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKV--LK 239
+W+ F LL+ ++ QE+ + +E DV G+ +L+ +H +L +++ +
Sbjct: 3273 QWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECR 3332
Query: 240 APVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMW 299
++L +EGQ+L+ ++ F S ++T L +L Q L + W
Sbjct: 3333 LQAQDLRQEGQQLVD----------------NSHFMS--AEVTECLQELEGRLQELEEAW 3374
Query: 300 HVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQ 335
+R + + + L+ Q E+ W++ + L L+
Sbjct: 3375 ALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLK 3410
Score = 39.7 bits (91), Expect = 0.025
Identities = 124/668 (18%), Positives = 245/668 (36%), Gaps = 71/668 (10%)
Query: 184 IELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVE 243
+E R L +FF A ++ +++ + A +++ + R L ++H L+ ++ + E
Sbjct: 2854 LEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEM--SSHE 2911
Query: 244 ELDR----EGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMW 299
L R G +L+Q + F+ ++ + + +L HL
Sbjct: 2912 ALTRVVLGTGYKLVQ----AGHFAAH--------------EVAARVQQLEKAMAHLRAEA 2953
Query: 300 HVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAM 359
R+L L Q + + F + + W++ + ++G S + A +
Sbjct: 2954 ARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVL--DSEDMGHSAE-ATQALLRRLEATK 3010
Query: 360 NSMNAY-VNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSA 418
+ A+ I R+ A+ L + S ++ + + + R L
Sbjct: 3011 RDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQL 3070
Query: 419 VFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKAL 478
HQ + L +DAW + +E QD + + L E+ EV G+A
Sbjct: 3071 QLHQLERETLL-LDAW---LTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAK 3126
Query: 479 LDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQL 538
+ L R L+ + +A ++ E RL+ + R L ++
Sbjct: 3127 VYAL-RKLAGTLERGAPRRYPHIQAQRSRIEAAWE------RLDQAIKARTENLAAAHEV 3179
Query: 539 CVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLL 598
FQQ ++ ++ + L K G SL R LQ++H E + +L
Sbjct: 3180 HSFQQAAAELQGRMQE--KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQ 3237
Query: 599 EAAEQLAQTGECDP---EEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWT 655
A +L Q P ++ +A L+ + Q+ + + Q +F +EL
Sbjct: 3238 TEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAA----QGHAFLGRCQELLA 3293
Query: 656 WMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSL 715
W ++ Q+ + A+ V ++L+ Q E+L Q++R
Sbjct: 3294 WAQERQELASSEELAEDVAGAEQLLGQH------------------EELGQEIRECRLQA 3335
Query: 716 GEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFE 775
+ + V N+ H S + + LQ+L+ ++EE + R + L+
Sbjct: 3336 QDLRQEGQQLVDNS---HFMS-AEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
Query: 776 QYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDL 835
Q + A L W LL+ + D+ L R Q E+ LA F +Q+ +
Sbjct: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ-DLEKLLAAQEEKFAQMQKTEME 3450
Query: 836 HQYITEVQ 843
+ + + Q
Sbjct: 3451 QELLLQPQ 3458
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 93.2 bits (230), Expect = 2e-18
Identities = 179/1029 (17%), Positives = 381/1029 (37%), Gaps = 160/1029 (15%)
Query: 189 SLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKK--VLKAPVEELD 246
+L+ F + +++ + +L +++ D+ S L H L++ V+ V+EL
Sbjct: 265 NLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELC 324
Query: 247 REGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKL 306
+ ++L + S P+I + + L S+ +H+ + R KL
Sbjct: 325 AKAEKL------------------TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKL 366
Query: 307 DQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVS-YQYALDLQTQHNHFAMNSMNAY 365
+ F D +++ W++ V+ + LD QH H + + +
Sbjct: 367 QATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRF 426
Query: 366 VNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFH---Q 422
+ + L A H AS ++++ LD W + DER FH +
Sbjct: 427 QSAD---ETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYR 483
Query: 423 KAEQFLSGVDAWCK----MCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKAL 478
+EQ VD+W L + + E + H+ E T ++ K
Sbjct: 484 DSEQ----VDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTA 539
Query: 479 LDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQL 538
++ +SE++ A + A D + E +RRL L + L L
Sbjct: 540 TKLIGD--DHYDSENIKAIRDGLLARR---DALREKAATRRRL----------LKESLLL 584
Query: 539 CVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLL 598
+D + +WI + + K + ++ ++ FE+ T + +
Sbjct: 585 QKLYEDSDDLKNWINKKKKLADDEDY---KDIQNLKSRVQKQQVFEKELAVNKTQLENIQ 641
Query: 599 EAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLL---DMSVSFHTHTKELWT 655
+ +++ + G + + + ++ + +Q+ L + + F + ++L
Sbjct: 642 KTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQR 701
Query: 656 WMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSL 715
W+ED++ ++ + + VQ +++ L++ + ++ D++ L + +
Sbjct: 702 WLEDVEWQVTSEDYGKGLAEVQNRLRKH-----GLLESAVAARQDQVDILTDLAAYFEEI 756
Query: 716 GEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFE 775
G P + + S + E++ + L + ++ +L H + I D
Sbjct: 757 GHPDS------KDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRD--------- 801
Query: 776 QYTIEVTAELDAW-NEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQD 834
T + +AW E + + +DL +++ L RH VI +
Sbjct: 802 ------TEDEEAWIQETEPSATSTYLGKDLIASKKLLNRH------------RVILENIA 843
Query: 835 LHQ-YITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLR 893
H+ I E+ G +++ E+ A V ++ L++ L A + LE +Q +
Sbjct: 844 SHEPRIQEITERGNKMV-EEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQ 902
Query: 894 HLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTH 953
A++ + WIR E +++ + A A L ++HE F L + S + +
Sbjct: 903 QYLADLHEAETWIREKEPIVDNTNYGADE-EAAGALLKKHEAFLLDLNSFGDSMKALRNQ 961
Query: 954 QSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSE 1013
+A Q QQ A V AG A+ + + +++ +K D
Sbjct: 962 ANACQQQQAAPVEGVAGEQRVMALYDFQARSP---REVTMKKGD---------------- 1002
Query: 1014 QVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNA 1073
V ++L S+ +++ + E AA+ ++P A + R
Sbjct: 1003 -VLTLLSSINKDWWKVE-----------AADHQGIVP--------------AVYVRRLAH 1036
Query: 1074 EVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYV 1133
+ F R ++ E Q +++L +R +RRL Q
Sbjct: 1037 DEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEER-----------RRRLLQRYNEF 1085
Query: 1134 VFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQ 1193
+ A L+WIQE +TG ++ EL K++ EF+ + +++ + +
Sbjct: 1086 LLAYEAGDMLEWIQE------KKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINK 1139
Query: 1194 LADSFVEKG 1202
+AD + +G
Sbjct: 1140 VADDLLFEG 1148
Score = 88.2 bits (217), Expect = 6e-17
Identities = 202/1047 (19%), Positives = 397/1047 (37%), Gaps = 144/1047 (13%)
Query: 269 PGSADFQSLVPKITSLLDKLHSTRQHLHQMWHV-------RKLKLDQCFQLRLFEQDAEK 321
P +S PK+ +++ RQ + + R KL+ + L++F++DA+
Sbjct: 5 PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
Query: 322 MFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNI-NRIMSVASRLSE 380
+ WI + SY+ ++Q ++ S+ A V +R+MS + E
Sbjct: 65 LGKWIMEKVNILTDK------SYEDPTNIQGKYQKH--QSLEAEVQTKSRLMSELEKTRE 116
Query: 381 A----GHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCK 436
GH A ++ K +L W E+ L + F Q ++ + + W
Sbjct: 117 ERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQE-CADILEWI- 174
Query: 437 MCSEGGLPSEMQDLELAIHHHQT--LYEQVTQAYTE-VSQDGKAL-LDVLQRPLSPGNSE 492
G + +EL +T L+++ E V+++G+ + ++ + N
Sbjct: 175 ----GDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP 230
Query: 493 SLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWI 552
L + V+ + RL + R+ L L F++DV + + WI
Sbjct: 231 DLPLIQSKQNEVNAAWE----------RLRGLALQRQKALSNAANLQRFKRDVTEAIQWI 280
Query: 553 ENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDP 612
+ S+ GK L + L H E +L AE+L + D
Sbjct: 281 KEKEPVLTSE--DYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDA 338
Query: 613 EEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTK---ELWTWMEDLQKEMLEDVC 669
+I + L + R L + +H + EL WM + + D
Sbjct: 339 PQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADEL 398
Query: 670 ADSVDAVQELIKQFQQQQ---TATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAV 726
V + L+ + QQ + + D + + G+DL+ A + E E D
Sbjct: 399 PTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILD--- 455
Query: 727 SNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELD 786
NN T ++L+ D+ Q E+ LD L R EQ +D
Sbjct: 456 -NNWT----------ALLELWDERHRQYEQC-------LDFHLFYRDSEQ--------VD 489
Query: 787 AWNEDLLRQMNDFNTED----LTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEV 842
+W + RQ ED L AE LQ+H + FE Q+ + I V
Sbjct: 490 SW---MSRQEAFLENEDLGNSLGSAEALLQKHED---------FEEAFTAQE--EKIITV 535
Query: 843 QASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQV 902
+ +LI + D + ++ + + L ++ L A + L++ L L+ L + +
Sbjct: 536 DKTATKLIGDDHYD-SENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL 594
Query: 903 LGWIRNGESML-NASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQ 961
WI + + + + +L Q Q+ E+ +LA+ + T L+ +Q+
Sbjct: 595 KNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEK-ELAV----NKTQLE-------NIQK 642
Query: 962 KAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDR---LKLVNASVAFYKTSEQVCSV 1018
+ +++ GHY +D + +VA W++L+ + + L N + F +E +
Sbjct: 643 TGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRW 702
Query: 1019 LESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLK 1078
LE +E + ED+ G AE+ + + +K L++ AR++ L
Sbjct: 703 LEDVEWQV-TSEDYGKG------LAEVQNRL--------RKHGLLESAVAARQDQVDILT 747
Query: 1079 YI--HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFE 1136
+ + + P + ++A L+ R + +K++L +
Sbjct: 748 DLAAYFEEIGHPD--------SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLIC 799
Query: 1137 RSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLAD 1196
R + WIQET +T T G+ +++LL + + +++ + + +
Sbjct: 800 RDTEDEEAWIQETEP--SATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGN 857
Query: 1197 SFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDL-ELDIIPA 1255
VE+GH A ++ V +++++ R + + LE N + + L +L
Sbjct: 858 KMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE----ANVQFQQYLADLHEAET 913
Query: 1256 SLSDREVKLRDANHEVNEEKRKSARKK 1282
+ ++E + + N+ +EE + KK
Sbjct: 914 WIREKEPIVDNTNYGADEEAAGALLKK 940
Score = 85.9 bits (211), Expect = 3e-16
Identities = 200/1026 (19%), Positives = 387/1026 (37%), Gaps = 110/1026 (10%)
Query: 193 FFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRL 252
F + A L + + + M++ +E D+ G L++ H + D E +
Sbjct: 1294 FLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQE----------HRADMEAEA- 1342
Query: 253 LQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQL 312
+ + FS G P+I L + R L + W RK LDQC +L
Sbjct: 1343 -PTFQALEDFSAELIDSG----HHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLEL 1397
Query: 313 RLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIM 372
++F+ + +++ W+ +E L+S + + AL + A+ + I +
Sbjct: 1398 QMFQGNCDQVESWMV-ARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEG--KITDLE 1454
Query: 373 SVASRLSEAGHYASQQIKQISTQLDQEWKSFAAAL-DERSTI--LAMSAVFHQKAEQFLS 429
A L HYA ++I ++ WK+ A L DER+ + A F++ E+
Sbjct: 1455 HFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEE 1514
Query: 430 GVDAWC-KMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSP 488
+ C E + +++ HQT +V DG++ + + ++
Sbjct: 1515 WISEMLPTACDES--YKDATNIQRKYLKHQTFAHEV---------DGRS--EQVHGVINL 1561
Query: 489 GNS-ESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQ 547
GNS +A +A+ + L+ + E H LE K +L++ + F ++
Sbjct: 1562 GNSLIECSACDGNEEAMKEQLEQLKE--HWDHLLERTNDKGK-KLNEASRQQRFNTSIRD 1618
Query: 548 VLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQT 607
W+ + E L+ + L A L K+H E L AE L +
Sbjct: 1619 FEFWL-SEAETLLAM-KDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSS 1676
Query: 608 GECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLED 667
G + ++I K ++ R + + +++ + H KE + + +D
Sbjct: 1677 GTFNVDQIVKKKDNVNKRFLN----------VQELAAAHHEKLKEAYALF-----QFFQD 1721
Query: 668 VCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVS 727
+ + ++LI+ Q L N++K+ + L +L + P++ + +
Sbjct: 1722 LDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-- 1779
Query: 728 NNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDA 787
K + I+ L Q + +++EL R +KL+ L+ F Q E +A
Sbjct: 1780 --KDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQN----AEEEEA 1833
Query: 788 W-NEDLLRQMNDFNTEDLTLAEQRLQRH--TERKLAMNNMTFE-VIQQGQDLHQYITEVQ 843
W NE + + L + L +H E A++ + V QG+D+ + + +
Sbjct: 1834 WINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEE 1893
Query: 844 ASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVL 903
+ E + +E L+EK L +LE + + V
Sbjct: 1894 SQNKE------------ISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVE 1941
Query: 904 GWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSAL-QVQQK 962
WI + E+ L + N + L + L + + SLQ Q L ++
Sbjct: 1942 AWIADKETSLKTN-GNGADLGDFLTLLAKQDTLD---------ASLQSFQQERLPEITDL 1991
Query: 963 AEVLLQAGHYDADAIRECAEKVALHWQQLM-LKMEDRLKLVNASVAFYKTSEQVCSVLES 1021
+ L+ A H + AI E + W+QL+ R KL+ + K + +
Sbjct: 1992 KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAED----LFVE 2047
Query: 1022 LEQEYRRDEDWCGGRDKLGPAAEIDHVIPL--ISKHLEQKEAFLKACTLARRNAEVFLKY 1079
+ +WC ++ +E H + L I + + E FL + A+ + + L+
Sbjct: 2048 FAHKASALNNWCEKMEE--NLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
Query: 1080 IHRNNV----SMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVF 1135
+ S P E+ K + + +RE + + + + CQ+ F
Sbjct: 2106 DQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQE---F 2162
Query: 1136 ERSAKQALDWIQETGEFYL--STHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQ 1193
E++A L WI ET ++L S TG + + ++ E + +Q + V L
Sbjct: 2163 EQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDN 2222
Query: 1194 LADSFV 1199
L D+ +
Sbjct: 2223 LEDALI 2228
Score = 77.8 bits (190), Expect = 8e-14
Identities = 162/779 (20%), Positives = 301/779 (38%), Gaps = 95/779 (12%)
Query: 513 EVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHR 572
++ + R L + R+ RL QR + + +L+WI+ K G L
Sbjct: 1059 QIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQE------KKAENTGVELDD 1112
Query: 573 ARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRR 632
LQK+ D+F++ + + A+ L G PE + + L R R
Sbjct: 1113 VWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGA-QIRQELNSRWGSLQRL 1171
Query: 633 VEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLD 692
++++ LL + H E++ D KE +E C ++ A F Q
Sbjct: 1172 ADEQRQLLGSA-----HAVEVFHREADDTKEQIEKKC-QALSAADPGSDLFSVQ------ 1219
Query: 693 ATLNVIKEG--EDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDA 750
L EG DL+ L LGE +E + H + ++ +L++A
Sbjct: 1220 -ALQRRHEGFERDLV-PLGDKVTILGETAERLSES-------HPDATEDLQRQKMELNEA 1270
Query: 751 QVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFN-TEDLTLAEQ 809
++ +RK L+ + +F + +L W + ++ EDLT E
Sbjct: 1271 WEDLQGRTKDRKESLNEAQKFYLF----LSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326
Query: 810 RLQRHTERKLAM--NNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEF 867
L+RH E + M TF Q L + E+ SG + ++++ L+
Sbjct: 1327 LLERHQEHRADMEAEAPTF------QALEDFSAELIDSGHH--------ASPEIEKKLQA 1372
Query: 868 LHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAE 927
+ ++ +LE E+ K L+QCL+L+ Q QV W+ E+ L + + SSL E
Sbjct: 1373 VKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSD--DKSSLDSLE 1430
Query: 928 QLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALH 987
L ++ + AI + ++ AE L+ HY + I ++V
Sbjct: 1431 ALMKKRDDLDKAITA---------QEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDR 1481
Query: 988 WQQLMLKM-EDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEID 1046
W+ L ++ ++R KL + Y +Q LE L E+W + L A +
Sbjct: 1482 WKALKAQLIDERTKLGD-----YANLKQFYRDLEEL-------EEWIS--EMLPTACDES 1527
Query: 1047 HVIPLISKHLEQKEAFLKACTLARR---NAEVFLKYIHRNNVSMPSVASHTRGPEQQVKA 1103
+ + ++++K +LK T A +E I+ N + S G E+ +K
Sbjct: 1528 Y---KDATNIQRK--YLKHQTFAHEVDGRSEQVHGVINLGNSLIE--CSACDGNEEAMKE 1580
Query: 1104 ILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGET 1163
L +L + + +L K ++L++ + F S + W+ E L
Sbjct: 1581 QLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET--LLAMKDQARD 1638
Query: 1164 TEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDF 1223
LLK++ ++ +K L LA+ + G + +I K V+K + +
Sbjct: 1639 LASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNV 1698
Query: 1224 SLRMGKYRYSLEKALGV-----NTEDNKD-LELDIIPASLSDREVKLRDANHEVNEEKR 1276
+ L++A + + +D + +E +I S D L+ + + + KR
Sbjct: 1699 QELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKR 1757
Score = 72.4 bits (176), Expect = 3e-12
Identities = 147/746 (19%), Positives = 291/746 (39%), Gaps = 97/746 (13%)
Query: 277 LVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQS 336
L P+ + +L+S L ++ ++ L + +F ++A+ + I K+ S
Sbjct: 1150 LTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIE--KKCQALS 1207
Query: 337 HTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQL 396
+ G LQ +H F + + + + A RLSE+ A++ +++ +L
Sbjct: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMEL 1267
Query: 397 DQEWKSFAAALDERSTILAMSAVFH---QKAEQFLSGVDAWCKMCSEGGLPSEMQDLELA 453
++ W+ +R L + F+ KA + + + M S L ++ +E+
Sbjct: 1268 NEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEIL 1327
Query: 454 IHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHE 513
+ HQ E D +A Q L ++E + + + S + + L V
Sbjct: 1328 LERHQ-----------EHRADMEAEAPTFQ-ALEDFSAELIDSGHHASPEIEKKLQAVK- 1374
Query: 514 VLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRA 573
+ LE W+ RK L Q L+L +FQ + QV W+ + S SL
Sbjct: 1375 --LERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDK---SSLDSL 1429
Query: 574 RALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRV 633
AL K+ DD ++ L AE L EEI A L+ R+ D + +
Sbjct: 1430 EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEI---ATRLQ-RVLDRWKAL 1485
Query: 634 EQRKLLLDMSVSFHTHTKELWTWMEDLQK---EMLEDVCADSVDAVQELIKQFQQQQT-- 688
+ + + + + + K+ + +E+L++ EML C +S + +++ + QT
Sbjct: 1486 KAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFA 1545
Query: 689 ----ATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVL 744
+ VI G LI+ A D K H + +L
Sbjct: 1546 HEVDGRSEQVHGVINLGNSLIE------------CSACDGNEEAMKEQLEQLKEHWDHLL 1593
Query: 745 QQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDL 804
++ +D ++ E +++ I R FE + E + L M D DL
Sbjct: 1594 ERTNDKGKKLNEASRQQRFNTSI----RDFEFWLSEA---------ETLLAMKD-QARDL 1639
Query: 805 TLAEQRLQRH--TERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQ 862
A L++H ER++ +DL+ ++ +SG ++D Q+
Sbjct: 1640 ASAGNLLKKHQLLEREMLAREDAL------KDLNTLAEDLLSSG-----TFNVD---QIV 1685
Query: 863 ELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVN-AS 921
+ + ++++ ++ A H++L++ L ++ WI E ++ S +
Sbjct: 1686 KKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIE--EKLIRVSSQDYGR 1743
Query: 922 SLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECA 981
L + L ++H+ +L E + H ++Q A +++ KA V + I+
Sbjct: 1744 DLQGVQNLLKKHK--RLEGELVAHEPAIQNVLDMAEKLKDKAAV-------GQEEIQLRL 1794
Query: 982 EKVALHWQQLM-------LKMEDRLK 1000
+ HW++L LK+E+ L+
Sbjct: 1795 AQFVEHWEKLKELAKARGLKLEESLE 1820
Score = 42.4 bits (98), Expect = 0.004
Identities = 103/554 (18%), Positives = 209/554 (37%), Gaps = 72/554 (12%)
Query: 180 HEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLK 239
H E ++ +L +FF S +E+ ++ +++ D++G + L+ +H +L+
Sbjct: 1705 HHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLE----- 1759
Query: 240 APVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMW 299
EL + + ++ + + G + Q + + +K L ++
Sbjct: 1760 ---GELVAHEPAIQNVLDMAEKLKDKAAV-GQEEIQLRLAQFVEHWEK-------LKELA 1808
Query: 300 HVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSH--TEIGVSYQYALDLQTQHNHF 357
R LKL++ + F Q+AE+ WI+ L ++ + + + + N F
Sbjct: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
Query: 358 AMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQ---LDQEWKSFAAALDERSTIL 414
A++ + + + + Q K+IS++ L+++ S A A+ L
Sbjct: 1869 AVHE----TRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQL 1924
Query: 415 AMSAVFHQKAEQFLSGVDAWC----KMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTE 470
F Q+ V+AW G +++ D + TL + E
Sbjct: 1925 EDDYAF-QEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
Query: 471 VSQDGKALLDVLQRPLSPGNSESLTATANYS---KAVHQVLDVVHEVLHHQRRLESIWQH 527
+ + D+ + +S +++S Y+ K Q+L+ +H Q+ LE
Sbjct: 1984 RLPE---ITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEA--SAVHRQKLLE----- 2033
Query: 528 RKVRLHQRLQLCV-FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEV 586
+++ L + L V F + +W E E V SL+ R LQK H+DF
Sbjct: 2034 KQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCV--SLNEIRQLQKDHEDFLAS 2091
Query: 587 AQNTYTNADKLLEAAEQLAQTGE-------CDPEEIYKAARHL----EVRIQDFVRRVEQ 635
+ LLE +Q+ G E + + +HL E R Q+ + +
Sbjct: 2092 LARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEAR 2151
Query: 636 RKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATL 695
+ +M F + W+ + + L+ L+K +T TL++ L
Sbjct: 2152 QVKNFEMCQEFEQNASTFLQWILETRAYFLDG----------SLLK-----ETGTLESQL 2196
Query: 696 NVIKEGEDLIQQLR 709
K + IQ ++
Sbjct: 2197 EANKRKQKEIQAMK 2210
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 90.1 bits (222), Expect = 2e-17
Identities = 91/358 (25%), Positives = 160/358 (44%), Gaps = 43/358 (12%)
Query: 1266 DANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNK 1325
D+ E ++ K R + +++EL +TE+ YV L + +L M + +
Sbjct: 8 DSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTE 67
Query: 1326 EHI--IFGNIQEIYDFHNNIFLKELEKY----EQLPEDVGHCFVTWADKFQMYVTYCKNK 1379
E + +F NI++I H FLK +E+ ++VG CF+ + DKF++Y YC N
Sbjct: 68 ETVKMLFSNIEDILAVHKE-FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNH 126
Query: 1380 PDSNQLILE-----HAGTFFDEIQQRHGLANS---ISSYLIKPVQRITKYQLLLKELLTC 1431
+ +L+LE TF G N+ + YL+ P+QRI KY L+LKELL
Sbjct: 127 EKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKR 186
Query: 1432 CEEGKGE---LKDGLEVMLSVPKKANDAMH----VSMLEGFDENLD-VQGELILQDAFQV 1483
+ + + L+ M +V N+A + +LE + +++ +G I ++
Sbjct: 187 TPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEM 246
Query: 1484 WDPKSLIRKG----RERHLFLFEISLVFSK----EIKDSSGHT---KYVYKNKLLTSELG 1532
L++ +ER FLF+ LV+ K +K+S T +Y+++ ++ T +
Sbjct: 247 LMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVME 306
Query: 1533 VTEHVEGDPCKFAL--------WSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQER 1582
V E+V+ F W + + V A E K EW + I + + R
Sbjct: 307 V-ENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERR 363
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 90.1 bits (222), Expect = 2e-17
Identities = 91/358 (25%), Positives = 160/358 (44%), Gaps = 43/358 (12%)
Query: 1266 DANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNK 1325
D+ E ++ K R + +++EL +TE+ YV L + +L M + +
Sbjct: 8 DSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTE 67
Query: 1326 EHI--IFGNIQEIYDFHNNIFLKELEKY----EQLPEDVGHCFVTWADKFQMYVTYCKNK 1379
E + +F NI++I H FLK +E+ ++VG CF+ + DKF++Y YC N
Sbjct: 68 ETVKMLFSNIEDILAVHKE-FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNH 126
Query: 1380 PDSNQLILE-----HAGTFFDEIQQRHGLANS---ISSYLIKPVQRITKYQLLLKELLTC 1431
+ +L+LE TF G N+ + YL+ P+QRI KY L+LKELL
Sbjct: 127 EKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKR 186
Query: 1432 CEEGKGE---LKDGLEVMLSVPKKANDAMH----VSMLEGFDENLD-VQGELILQDAFQV 1483
+ + + L+ M +V N+A + +LE + +++ +G I ++
Sbjct: 187 TPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEM 246
Query: 1484 WDPKSLIRKG----RERHLFLFEISLVFSK----EIKDSSGHT---KYVYKNKLLTSELG 1532
L++ +ER FLF+ LV+ K +K+S T +Y+++ ++ T +
Sbjct: 247 LMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVME 306
Query: 1533 VTEHVEGDPCKFAL--------WSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQER 1582
V E+V+ F W + + V A E K EW + I + + R
Sbjct: 307 V-ENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERR 363
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 87.4 bits (215), Expect = 1e-16
Identities = 214/1162 (18%), Positives = 444/1162 (38%), Gaps = 134/1162 (11%)
Query: 279 PKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHT 338
P + L + + + ++ +RK L L +A+ WI KE +L ++
Sbjct: 805 PDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDE-KEQWL-NNM 862
Query: 339 EIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQ 398
+I + +Q + N + + +A +L +GH + ++IK +L+
Sbjct: 863 QIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNT 922
Query: 399 EWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQ 458
W F +D + L +SA+ Q + +W + + + QDL +
Sbjct: 923 RWSQFRELVDRKKDAL-LSALSIQNYHLECNETKSWIR--EKTKVIESTQDLGNDLAGVM 979
Query: 459 TLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQ 518
L ++T + L ++ LS E+ + + +L + E+
Sbjct: 980 ALQRKLTGMERD--------LVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVW 1031
Query: 519 RRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQK 578
+++ ++R+ L + +L F +D+ W+ A S+ + +L A L
Sbjct: 1032 EEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE--DMPNTLTEAEKLLT 1089
Query: 579 RHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAAR--HLEVRIQDFVRRVEQR 636
+H++ + N + K+ + E + Q G+ D + ++ R L+ + + E R
Sbjct: 1090 QHENIKNEIDNYEEDYQKMRDMGEMVTQ-GQTDAQYMFLRQRLQALDTGWNELHKMWENR 1148
Query: 637 KLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLN 696
+ LL S ++ Q+ + + A++ QE + + T TL+
Sbjct: 1149 QNLLSQSHAY--------------QQFLRDTKQAEAFLNNQEYVLAHTEMPT-TLEGAEA 1193
Query: 697 VIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEE 756
IK+ ED + + + + E VS+ + + I+ + +DD + E
Sbjct: 1194 AIKKQEDFMTTMDANEEKINAVVETGRRLVSDG----NINSDRIQEKVDSIDDRHRKNRE 1249
Query: 757 LFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTE 816
E ++L L+ F ++ EL W + + D + ++ + +H
Sbjct: 1250 TASELLMRLKDNRDLQKF----LQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQA 1305
Query: 817 --RKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHE 874
+LA N +++ +++ G++LI EK + A V+E L LH+
Sbjct: 1306 FMAELASNK-------------EWLDKIEKEGMQLISEKP-ETEAVVKEKLTGLHKMWEV 1351
Query: 875 LELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNA-----SLVNASSLSEAEQ- 928
LE + +RL + + W+ ES + + L + + L + +Q
Sbjct: 1352 LESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQM 1411
Query: 929 LQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHW 988
L+ + E + IE L Q +A+ L Q G D + V +
Sbjct: 1412 LENQMEVRKKEIEEL----------------QSQAQALSQEGK-STDEVDSKRLTVQTKF 1454
Query: 989 QQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHV 1048
+L+ + +R + AS ++ + V E E W G R L + + H
Sbjct: 1455 MELLEPLNERKHNLLASKEIHQFNRDV-------EDEIL----WVGERMPLATSTDHGHN 1503
Query: 1049 IPLISKHLEQKEAFLKACTLAR-RNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSE 1107
+ + +++ + K + R ++F + S V + + ++ L++
Sbjct: 1504 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFER-------SQNIVTDSSSLSAEAIRQRLAD 1556
Query: 1108 LLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEET 1167
L Q ++ + RRL++ + + A +A W+ E + +S + E +
Sbjct: 1557 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE--QSA 1614
Query: 1168 QELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRM 1227
+LK++ + E V L + + + V H + I + VDK Y
Sbjct: 1615 VSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLA 1674
Query: 1228 GKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVKL------RDANH--EVNEEKRKSA 1279
+ R L++ + + E+D + +++REV +D H + E R+ A
Sbjct: 1675 EERRGKLDER---HRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA 1731
Query: 1280 RKKEFIMAELLQTEKAYVRDL----HECLETYLWEMTSGVEEIPPGIL---NKEHIIFGN 1332
R I E + T +L H T + E G+ E +L + I
Sbjct: 1732 RDTGNIGQERVDTVNHLADELINSGHSDAAT-IAEWKDGLNEAWADLLELIDTRTQILAA 1790
Query: 1333 IQEIYDFHNN---IFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKN----------- 1378
E++ F+++ IF + +K+++LPE++G T +M+ T+ +
Sbjct: 1791 SYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1850
Query: 1379 KPDSNQLILEHAGTFFDEIQQR 1400
+ D+ +L +AG D+IQ+R
Sbjct: 1851 QEDAARLQAAYAGDKADDIQKR 1872
Score = 74.3 bits (181), Expect = 9e-13
Identities = 204/1047 (19%), Positives = 413/1047 (39%), Gaps = 158/1047 (15%)
Query: 179 NHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVL 238
N + + + ++F + L + + +LA E P +EG+ I +
Sbjct: 1147 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDF----- 1201
Query: 239 KAPVEELDREGQRLLQCIRCSDGFSGRNCI-PGSADFQSLVPKITSLLDKLHSTRQHLHQ 297
+ +D +++ + +GR + G+ + + K+ S+ D+ R+ +
Sbjct: 1202 ---MTTMDANEEKINAVVE-----TGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASE 1253
Query: 298 MWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQT---QH 354
+ ++L L+ F QD +++ WI N+++ T +SY A +L + +H
Sbjct: 1254 L----LMRLKDNRDLQKFLQDCQELSLWI--NEKML----TAQDMSYDEARNLHSKWLKH 1303
Query: 355 NHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTIL 414
F + +++I +L +K+ T L + W+ L+ +
Sbjct: 1304 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE----VLESTTQTK 1359
Query: 415 AMSAVFHQKAEQF---LSGVDAWC--------------KMCSEGGLPSEMQDLELAIHHH 457
A KAE F + +D W + S L + Q LE +
Sbjct: 1360 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVR 1419
Query: 458 QTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHH 517
+ E++ +SQ+GK+ +V +S+ LT + + + + + H +L
Sbjct: 1420 KKEIEELQSQAQALSQEGKSTDEV--------DSKRLTVQTKFMELLEPLNERKHNLLAS 1471
Query: 518 QRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAF-LSKHTGVGKSLHRARAL 576
+ +HQ F +DV+ + W+ GE L+ T G +L + L
Sbjct: 1472 K------------EIHQ------FNRDVEDEILWV---GERMPLATSTDHGHNLQTVQLL 1510
Query: 577 QKRHDDFEEVAQNTYTNADKLLEAAEQL-AQTGECDPEEIYKAARHLEVRIQDFVRRVEQ 635
K++ ++ Q D + E ++ + + E I + L+ + E+
Sbjct: 1511 IKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEK 1570
Query: 636 RKLLLD---MSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLD 692
R L+ + ++ E WM + + M+ + A + ++K+ Q + A
Sbjct: 1571 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQA--- 1627
Query: 693 ATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQV 752
+++ + + QL +L S P S IS +S ++D
Sbjct: 1628 -----VEDYAETVHQLSKTSRALVADSH-----------PESERISMRQS---KVDKLYA 1668
Query: 753 QMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAW--NEDLLRQMNDF--NTEDLTLAE 808
+++L ER+ KLD + R+F Q EV +L+ W +++ ++ + E +T+ +
Sbjct: 1669 GLKDLAEERRGKLD--ERHRLF-QLNREVD-DLEQWIAEREVVAGSHELGQDYEHVTMLQ 1724
Query: 809 QRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFL 868
+R R+ A + T + Q+ D ++ + ELI D AA + E + L
Sbjct: 1725 ERF-----REFARD--TGNIGQERVDTVNHLAD------ELINSGHSD-AATIAEWKDGL 1770
Query: 869 HEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQ 928
+E +L + + L +L + K++ G I++ L L + E
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEEL--GRDQNTVET 1828
Query: 929 LQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHW 988
LQR H F+ I++L T +++ + A ++Q AG AD I++ +V W
Sbjct: 1829 LQRMHTTFEHDIQAL--GTQVRQLQEDAARLQ-----AAYAGD-KADDIQKRENEVLEAW 1880
Query: 989 QQLMLKMED-RLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDH 1047
+ L+ E R++LV+ F + V ++ +E R+ E RD +
Sbjct: 1881 KSLLDACESRRVRLVDTGDKF-RFFSMVRDLMLWMEDVIRQIEAQEKPRD-------VSS 1932
Query: 1048 VIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSE 1107
V L++ H +KA AR ++ + ++ ++ AS +++K L +
Sbjct: 1933 VELLMNNH-----QGIKAEIDARNDSFTTCIELGKSLLARKHYAS------EEIKEKLLQ 1981
Query: 1108 LLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEET 1167
L ++ ++ W + L + F R A A W+ E YLS+ G++ +E
Sbjct: 1982 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQ-EPYLSSR-EIGQSVDEV 2039
Query: 1168 QELLKEYGEFRVPAKQTKEKVKLLIQL 1194
++L+K + F A E+ L +L
Sbjct: 2040 EKLIKRHEAFEKSAATWDERFSALERL 2066
Score = 66.6 bits (161), Expect = 2e-10
Identities = 118/596 (19%), Positives = 233/596 (39%), Gaps = 57/596 (9%)
Query: 144 SSKFIFETSMVSVEGLT-KLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
S + ++S +S E + +L D QL + H E + + +F++A +
Sbjct: 1535 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAA-EAEA 1593
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
+ + + + +E D + + ++ +H ++L+ VE+ +L +
Sbjct: 1594 WMSEQELYMMSEEKAKDEQSAVSMLKKH-----QILEQAVEDYAETVHQLSK-------- 1640
Query: 263 SGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKM 322
+ R + S + S +DKL++ + L + R+ KLD+ +L ++ + +
Sbjct: 1641 TSRALVADSHPESERISMRQSKVDKLYAGLKDLAEE---RRGKLDERHRLFQLNREVDDL 1697
Query: 323 FDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMN-AYVNINRIMSVASRLSEA 381
WI+ +E+ SH E+G Y++ LQ + FA ++ N ++ + +A L +
Sbjct: 1698 EQWIAE-REVVAGSH-ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINS 1755
Query: 382 GHYASQQIKQISTQLDQEWKSFAAALDERSTILAMS----AVFHQKAEQFLSGVDAWCKM 437
GH + I + L++ W +D R+ ILA S +H E F D K+
Sbjct: 1756 GHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL 1815
Query: 438 CSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTAT 497
E L + +E H T + T+V Q LQ ++ L A
Sbjct: 1816 PEE--LGRDQNTVETLQRMHTTFEHDIQALGTQVRQ--------LQE-----DAARLQAA 1860
Query: 498 ANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGE 557
KA + +EVL + L + R+VRL F V+ ++ W+E+
Sbjct: 1861 YAGDKA-DDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIR 1919
Query: 558 AFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYK 617
++ + + L H + + +E + L EEI +
Sbjct: 1920 QIEAQEK--PRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1977
Query: 618 AARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKE---LWTWMEDLQKEMLEDVCADSVD 674
L + ++ + + E R L + + H +++ W+ + + SVD
Sbjct: 1978 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2037
Query: 675 AVQELIKQFQ--QQQTATLD---------ATLNVIKEGEDLIQQLRSAPPSLGEPS 719
V++LIK+ + ++ AT D TL +++ ++ R P EPS
Sbjct: 2038 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2093
Score = 42.7 bits (99), Expect = 0.003
Identities = 94/506 (18%), Positives = 210/506 (41%), Gaps = 65/506 (12%)
Query: 520 RLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHG---EAFLSKHTGV------GKSL 570
RLE R++ L L + Q+ ++Q+ + E +LS++ + G L
Sbjct: 385 RLEKAEHERELALRNEL---IRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDL 441
Query: 571 HRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFV 630
A K+H+ E ++ A +L D + I A + +R+ +++
Sbjct: 442 PAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRI-TARKDNVIRLWEYL 500
Query: 631 RRV-EQRKLLLDMSVSFHTHTKEL---WTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQ 686
+ R+ L+M++ +E+ WM++++ +L + V++L+ Q
Sbjct: 501 LELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLL-----Q 555
Query: 687 QTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQ 746
+ ++A + + E + + GE + D V ++ ++H+E Q+
Sbjct: 556 KHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR------VAHMEFCYQE 609
Query: 747 LDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAW--NEDLLRQMNDFNTEDL 804
L +L ER+ +L+ + R ++ E+ AE + W ++ + +D+ +DL
Sbjct: 610 LC-------QLAAERRARLE---ESRRLWKFFWEM-AEEEGWIREKEKILSSDDYG-KDL 657
Query: 805 TLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQEL 864
T + L +H FE G+ H + G ++I E+ + +++E
Sbjct: 658 TSVMRLLSKHR---------AFEDEMSGRSGH--FEQAIKEGEDMIAEEHFG-SEKIRER 705
Query: 865 LEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLS 924
+ ++ E+ LE + KRLE+ L QA+ + W+ + ++++S V S
Sbjct: 706 IIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYS 765
Query: 925 EAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKV 984
+ L ++H+ +A E + +L H+ A + Q+ H ++ +R +
Sbjct: 766 -TQSLVKKHK--DVAEEIANYRPTLDTLHEQASALPQE--------HAESPDVRGRLSGI 814
Query: 985 ALHWQQLMLKMEDRLKLVNASVAFYK 1010
++++ R + + ++A YK
Sbjct: 815 EERYKEVAELTRLRKQALQDTLALYK 840
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,488,323
Number of Sequences: 37866
Number of extensions: 2667841
Number of successful extensions: 11761
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 432
Number of HSP's that attempted gapping in prelim test: 9576
Number of HSP's gapped (non-prelim): 1847
length of query: 1663
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1547
effective length of database: 13,855,062
effective search space: 21433780914
effective search space used: 21433780914
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.