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Search of human proteins with 4504191
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504191 mutS homolog 6 [Homo sapiens]
(1360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504191 mutS homolog 6 [Homo sapiens] 2742 0.0
gi|68303635 mutS homolog 3 [Homo sapiens] 290 5e-78
gi|4557761 mutS homolog 2 [Homo sapiens] 233 7e-61
gi|4505253 mutS homolog 5 isoform c [Homo sapiens] 142 2e-33
gi|26638666 mutS homolog 5 isoform c [Homo sapiens] 142 2e-33
gi|26638662 mutS homolog 5 isoform a [Homo sapiens] 141 4e-33
gi|26638664 mutS homolog 5 isoform b [Homo sapiens] 138 4e-32
gi|36949366 mutS homolog 4 [Homo sapiens] 129 2e-29
gi|13699811 WHSC1L1 protein isoform long [Homo sapiens] 76 3e-13
gi|13699813 WHSC1L1 protein isoform short [Homo sapiens] 76 3e-13
gi|19913356 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 72 4e-12
gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 72 4e-12
gi|6594683 Wolf-Hirschhorn syndrome candidate 1 protein isoform ... 72 4e-12
gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 72 4e-12
gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 72 4e-12
gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isofor... 72 4e-12
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 55 6e-07
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 55 6e-07
gi|94721344 zinc finger, CW type with PWWP domain 1 [Homo sapiens] 53 2e-06
gi|27477095 nuclear receptor binding SET domain protein 1 isofor... 53 2e-06
gi|19923586 nuclear receptor binding SET domain protein 1 isofor... 53 2e-06
gi|221316599 chromogranin B precursor [Homo sapiens] 53 2e-06
gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo... 52 4e-06
gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo... 52 4e-06
gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo ... 52 4e-06
gi|221219020 NYD-SP11 protein [Homo sapiens] 51 7e-06
gi|40556376 cytokine-like nuclear factor n-pac [Homo sapiens] 47 1e-04
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens] 45 4e-04
gi|7705320 hepatoma-derived growth factor, related protein 3 [Ho... 45 5e-04
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 45 5e-04
>gi|4504191 mutS homolog 6 [Homo sapiens]
Length = 1360
Score = 2742 bits (7109), Expect = 0.0
Identities = 1360/1360 (100%), Positives = 1360/1360 (100%)
Query: 1 MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL 60
MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL
Sbjct: 1 MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL 60
Query: 61 ARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFI 120
ARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFI
Sbjct: 61 ARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFI 120
Query: 121 REKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRAD 180
REKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRAD
Sbjct: 121 REKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRAD 180
Query: 181 EALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRR 240
EALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRR
Sbjct: 181 EALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRR 240
Query: 241 SSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKR 300
SSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKR
Sbjct: 241 SSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKR 300
Query: 301 KRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSS 360
KRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSS
Sbjct: 301 KRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSS 360
Query: 361 RPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQN 420
RPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQN
Sbjct: 361 RPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQN 420
Query: 421 FDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKV 480
FDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKV
Sbjct: 421 FDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKV 480
Query: 481 ARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLL 540
ARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLL
Sbjct: 481 ARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLL 540
Query: 541 SLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGN 600
SLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGN
Sbjct: 541 SLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGN 600
Query: 601 LSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLK 660
LSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLK
Sbjct: 601 LSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLK 660
Query: 661 GMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTT 720
GMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTT
Sbjct: 661 GMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTT 720
Query: 721 RSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCA 780
RSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCA
Sbjct: 721 RSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCA 780
Query: 781 PLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDS 840
PLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDS
Sbjct: 781 PLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDS 840
Query: 841 RAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEG 900
RAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEG
Sbjct: 841 RAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEG 900
Query: 901 RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN 960
RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN
Sbjct: 901 RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN 960
Query: 961 RIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLIN 1020
RIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLIN
Sbjct: 961 RIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLIN 1020
Query: 1021 AEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVIL 1080
AEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVIL
Sbjct: 1021 AEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVIL 1080
Query: 1081 LPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGK 1140
LPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGK
Sbjct: 1081 LPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGK 1140
Query: 1141 STLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASI 1200
STLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASI
Sbjct: 1141 STLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASI 1200
Query: 1201 LMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNV 1260
LMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNV
Sbjct: 1201 LMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNV 1260
Query: 1261 AVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKA 1320
AVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKA
Sbjct: 1261 AVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKA 1320
Query: 1321 REFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL 1360
REFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL
Sbjct: 1321 REFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL 1360
>gi|68303635 mutS homolog 3 [Homo sapiens]
Length = 1137
Score = 290 bits (743), Expect = 5e-78
Identities = 260/965 (26%), Positives = 449/965 (46%), Gaps = 133/965 (13%)
Query: 407 TPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLV-FMKGNWAHSGFPEIA 465
TP ++ ++K Q+ D V+C + G Y + DA I EL + + N+ + P
Sbjct: 230 TPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHR 289
Query: 466 FGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGT---- 521
+ LV KGYKV V+QTET + + + S R++ + TK T
Sbjct: 290 LFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSLFS-------RKLTALYTKSTLIGE 342
Query: 522 QTYSVLEGDPSENYSK--------YLLSLKEKEEDSSGHTRA---YGVCFVDTSLGKFFI 570
+++ D + N + YLL + E +E+ + G+ V + G+
Sbjct: 343 DVNPLIKLDDAVNVDEIMTDTSTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVF 402
Query: 571 GQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQ---- 626
F D S T ++ PV++L LS++T+ ++ + S S+Q+ I +
Sbjct: 403 DSFQDSASRSELETRMSSLQPVELLLPSA-LSEQTEALIHRATSVSVQDDRIRVERMDNI 461
Query: 627 FWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGG 686
+++ S + + E F K D + + Q++ G+ + + + +L
Sbjct: 462 YFEYSHAFQAVTE---FYAK--DTVDIKGSQIISGIVNLEKPV-----------ICSLAA 505
Query: 687 CVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIF 746
+ YLK+ +++ L NF++ + + M ++ TL NLEI
Sbjct: 506 IIKYLKEFNLEKMLSKPENFKQ-----------------LSSKMEFMTINGTTLRNLEIL 548
Query: 747 LNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKI- 805
N T+ T+G+LL +D T FG+R LK+W+ PL IN RLDA+ +++ +
Sbjct: 549 QNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVF 608
Query: 806 SEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGF 865
++ L+KLPD+ER L I++ + + +T Y K
Sbjct: 609 GQIENHLRKLPDIERGLCSIYH-------KKCSTQEFFLIVKTLYHLKS----------- 650
Query: 866 KVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTG 925
+ I+ V +S +L+ VI P+L + + + E+A K G
Sbjct: 651 ----EFQAIIPAVNSHIQSDLLRTVIL--------EIPELLSPVEHYLKILN-EQAAKVG 697
Query: 926 LITPKAGFDSDYDQALADIRENE-QSLLE----YLEKQRNRIGCRTIVYWGIGRNRYQLE 980
T SD+ L R++E Q +++ +L++ R + + Y + + +E
Sbjct: 698 DKTELFKDLSDFP--LIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIE 755
Query: 981 IPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRR---LF 1037
I +N +P ++ + K R+ + I + +L + R+ + DC
Sbjct: 756 I-KNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHL---NQLREQLVLDCSAEWLDFL 811
Query: 1038 YNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVILLPEDTPPFLELKGSRHP 1097
F ++Y AV +A +D + LA ++ GD CRP + + +K RHP
Sbjct: 812 EKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGD--YCRPTVQEERK----IVIKNGRHP 865
Query: 1098 CITKTFFG--DDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQ 1155
I G D ++PN+ + + E +++TGPNMGGKS+ ++Q L+ +MAQ
Sbjct: 866 VID-VLLGEQDQYVPNNTDLSEDSER-------VMIITGPNMGGKSSYIKQVALITIMAQ 917
Query: 1156 MGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDEL 1215
+G YVPAE + +D +FTR+GA+D I G STF EL++TA I+ AT+ SLV++DEL
Sbjct: 918 IGSYVPAEEATIGIVDGIFTRMGAADNIYKGRSTFMEELTDTAEIIRKATSQSLVILDEL 977
Query: 1216 GRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLG--HMACMV-E 1272
GRGT+T DG AIA A ++ +K TLF THY + E +N + ++G HM +V E
Sbjct: 978 GRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCE-LEKNYSHQVGNYHMGFLVSE 1036
Query: 1273 NECE-DPS-----QETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKM 1326
+E + DP + +TFLY+ +G +SYG N A+LA++P E+++K K++E E +
Sbjct: 1037 DESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGL 1096
Query: 1327 NQSLR 1331
+ R
Sbjct: 1097 INTKR 1101
>gi|4557761 mutS homolog 2 [Homo sapiens]
Length = 934
Score = 233 bits (595), Expect = 7e-61
Identities = 217/821 (26%), Positives = 358/821 (43%), Gaps = 112/821 (13%)
Query: 521 TQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCS 580
+Q +L G+ + S ++ +K D R GV +VD+ K + +F D+ S
Sbjct: 129 SQFEDILFGNNDMSASIGVVGVKMSAVDGQ---RQVGVGYVDSIQRKLGLCEFPDNDQFS 185
Query: 581 RFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEE 640
L+ P + + G + + L +Q G I ++ A + + + ++
Sbjct: 186 NLEALLIQIGPKECVLPGGETAGDM-----GKLRQIIQRGGILITERKKADFSTKDIYQD 240
Query: 641 EYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQEL 700
L ++LKG E + + P ++++A+S+L + +L+ D
Sbjct: 241 --------------LNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNF 286
Query: 701 ----LSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEG 756
L+ +F +Y+ LD V LN + + T GS
Sbjct: 287 GQFELTTFDFSQYMKLDIAAVRA--------------------LNLFQGSVEDTTGSQ-- 324
Query: 757 TLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVE-LLKKL 815
+L ++ C TP G+RL+ QW+ PL + I +RL+ +E + + + E LL++
Sbjct: 325 SLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRF 384
Query: 816 PDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIM 875
PDL RL K + L+ D +G + +I +
Sbjct: 385 PDLNRLAKKFQRQAANLQ-----------------------DCYRLYQGINQLPNVIQAL 421
Query: 876 EEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFD- 934
E+ +G K+L V + F + +T D ++ + K FD
Sbjct: 422 EK-HEGKHQKLLLAVFVTPLTDLRSDFSKFQEMI---ETTLDMDQVENHEFLV-KPSFDP 476
Query: 935 --SDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIP--ENFTTRNL 990
S+ + + D+ + QS L + + I + Y + E RN
Sbjct: 477 NLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNN 536
Query: 991 PEEYELKSTKKGCK---RYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKD- 1046
+ K G K T E+ N EE +D +K+ + N Y +
Sbjct: 537 KNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIV-----NISSGYVEP 591
Query: 1047 WQSAVECIAVLDVLLCLANYSRGGDGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGD 1106
Q+ + +A LD ++ A+ S G P RP IL E + LK SRH C+ D
Sbjct: 592 MQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAIL--EKGQGRIILKASRHACVEVQ---D 646
Query: 1107 D--FIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEV 1164
+ FIPND+ E K ++TGPNMGGKST +RQ G++ +MAQ+GC+VP E
Sbjct: 647 EIAFIPNDVYF-------EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCES 699
Query: 1165 CRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDG 1224
++ +D + R+GA D + G STF E+ ETASIL AT SL+++DELGRGT+T+DG
Sbjct: 700 AEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDG 759
Query: 1225 TAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETIT 1284
+A A+ + +A I +F+TH+H L +Q V H+ + ++ET+T
Sbjct: 760 FGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALT-------TEETLT 812
Query: 1285 FLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEK 1325
LY+ KG C +S+G + A LAN P+ VI+ +KA E E+
Sbjct: 813 MLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEE 853
>gi|4505253 mutS homolog 5 isoform c [Homo sapiens]
Length = 834
Score = 142 bits (359), Expect = 2e-33
Identities = 176/669 (26%), Positives = 294/669 (43%), Gaps = 106/669 (15%)
Query: 679 LALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAV 738
L + ALGG + +L + I EL E+Y VS G + +D
Sbjct: 178 LTVRALGGLLKFLGRRRIGVEL------EDY------NVSVPILGFKKFMLTHLVNIDQD 225
Query: 739 TLNNLEIFLNGTN--------GSTEG-TLLERVDTCHTPFGKRLLKQWLCAPLCNHYAIN 789
T + L+IF + ++ G EG +L ++ CH +G++LL+ W P + ++
Sbjct: 226 TYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELS 285
Query: 790 DRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYE--- 846
RLD I+ ++P + ++ ++L RLL I NV LK ++ ++
Sbjct: 286 SRLDVIQ-FFLLPQNL-DMAQML------HRLLGHIKNVPLILKRMKLSHTKVSDWQVLY 337
Query: 847 ETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFK------SKILKQVISLQTKNPEG 900
+T YS + D +L + I + ++A F + ++ +V+ + E
Sbjct: 338 KTVYSALGLRDACRSLP------QSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAEN 391
Query: 901 RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN 960
RF L D D +K R GL L ++ E LE +
Sbjct: 392 RF----TVLPNIDPEIDEKKRRLMGL-----------PSFLTEVARKE------LENLDS 430
Query: 961 RIGCRTIVYWGIGRNRYQLEIPE--------NFTTRNLPEEYELKSTKKGCKRYWTKTIE 1012
RI +++Y I + L IP +F L + L K + TK ++
Sbjct: 431 RIPSCSVIY--IPLIGFLLSIPRLPSMVEASDFEINGLDFMF-LSEEKLHYRSARTKELD 487
Query: 1013 KKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSR--GG 1070
L +L + E R +L M +L ++ + LDVLL LA+ +R G
Sbjct: 488 ALLGDL-HCEIRDQETL--LMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGY 544
Query: 1071 DGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCV 1130
P P +L + ++ RHP + F+PN G + K
Sbjct: 545 SRPRYSPQVL-------GVRIQNGRHPLME--LCARTFVPNSTECGGD-------KGRVK 588
Query: 1131 LVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTF 1190
++TGPN GKS ++Q GL+ MA +G +VPAE + +D +FTR+ + + I G STF
Sbjct: 589 VITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTF 648
Query: 1191 FVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKE-LAETIKCRTLF-STH 1248
++L++ A + +ATA SLVL+DE G+GT T DG A+ AV++ LA C +F +T+
Sbjct: 649 MIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATN 708
Query: 1249 YHSLVEDYSQNVAVRLGHMACMVENE-CEDPSQETITFLYKFIKGACPKSYGFNAARLAN 1307
+ SLV Q + G + + E CED + + F Y+ +G S+ + A A
Sbjct: 709 FLSLV----QLQLLPQGPLVQYLTMETCEDGND--LVFFYQVCEGVAKASHASHTAAQAG 762
Query: 1308 LPEEVIQKG 1316
LP++++ +G
Sbjct: 763 LPDKLVARG 771
>gi|26638666 mutS homolog 5 isoform c [Homo sapiens]
Length = 834
Score = 142 bits (359), Expect = 2e-33
Identities = 176/669 (26%), Positives = 294/669 (43%), Gaps = 106/669 (15%)
Query: 679 LALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAV 738
L + ALGG + +L + I EL E+Y VS G + +D
Sbjct: 178 LTVRALGGLLKFLGRRRIGVEL------EDY------NVSVPILGFKKFMLTHLVNIDQD 225
Query: 739 TLNNLEIFLNGTN--------GSTEG-TLLERVDTCHTPFGKRLLKQWLCAPLCNHYAIN 789
T + L+IF + ++ G EG +L ++ CH +G++LL+ W P + ++
Sbjct: 226 TYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELS 285
Query: 790 DRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYE--- 846
RLD I+ ++P + ++ ++L RLL I NV LK ++ ++
Sbjct: 286 SRLDVIQ-FFLLPQNL-DMAQML------HRLLGHIKNVPLILKRMKLSHTKVSDWQVLY 337
Query: 847 ETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFK------SKILKQVISLQTKNPEG 900
+T YS + D +L + I + ++A F + ++ +V+ + E
Sbjct: 338 KTVYSALGLRDACRSLP------QSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAEN 391
Query: 901 RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN 960
RF L D D +K R GL L ++ E LE +
Sbjct: 392 RF----TVLPNIDPEIDEKKRRLMGL-----------PSFLTEVARKE------LENLDS 430
Query: 961 RIGCRTIVYWGIGRNRYQLEIPE--------NFTTRNLPEEYELKSTKKGCKRYWTKTIE 1012
RI +++Y I + L IP +F L + L K + TK ++
Sbjct: 431 RIPSCSVIY--IPLIGFLLSIPRLPSMVEASDFEINGLDFMF-LSEEKLHYRSARTKELD 487
Query: 1013 KKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSR--GG 1070
L +L + E R +L M +L ++ + LDVLL LA+ +R G
Sbjct: 488 ALLGDL-HCEIRDQETL--LMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGY 544
Query: 1071 DGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCV 1130
P P +L + ++ RHP + F+PN G + K
Sbjct: 545 SRPRYSPQVL-------GVRIQNGRHPLME--LCARTFVPNSTECGGD-------KGRVK 588
Query: 1131 LVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTF 1190
++TGPN GKS ++Q GL+ MA +G +VPAE + +D +FTR+ + + I G STF
Sbjct: 589 VITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTF 648
Query: 1191 FVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKE-LAETIKCRTLF-STH 1248
++L++ A + +ATA SLVL+DE G+GT T DG A+ AV++ LA C +F +T+
Sbjct: 649 MIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATN 708
Query: 1249 YHSLVEDYSQNVAVRLGHMACMVENE-CEDPSQETITFLYKFIKGACPKSYGFNAARLAN 1307
+ SLV Q + G + + E CED + + F Y+ +G S+ + A A
Sbjct: 709 FLSLV----QLQLLPQGPLVQYLTMETCEDGND--LVFFYQVCEGVAKASHASHTAAQAG 762
Query: 1308 LPEEVIQKG 1316
LP++++ +G
Sbjct: 763 LPDKLVARG 771
>gi|26638662 mutS homolog 5 isoform a [Homo sapiens]
Length = 851
Score = 141 bits (356), Expect = 4e-33
Identities = 162/613 (26%), Positives = 274/613 (44%), Gaps = 94/613 (15%)
Query: 735 LDAVTLNNLEIFLNGTN--------GSTEG-TLLERVDTCHTPFGKRLLKQWLCAPLCNH 785
+D T + L+IF + ++ G EG +L ++ CH +G++LL+ W P +
Sbjct: 239 IDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDL 298
Query: 786 YAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMY 845
++ RLD I+ ++P + ++ ++L RLL I NV LK ++ +
Sbjct: 299 GELSSRLDVIQ-FFLLPQNL-DMAQML------HRLLGHIKNVPLILKRMKLSHTKVSDW 350
Query: 846 E---ETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFK------SKILKQVISLQTK 896
+ +T YS + D +L + I + ++A F + ++ +V+ +
Sbjct: 351 QVLYKTVYSALGLRDACRSLP------QSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGS 404
Query: 897 NPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLE 956
E RF L D D +K R GL L ++ E LE
Sbjct: 405 LAENRF----TVLPNIDPEIDEKKRRLMGL-----------PSFLTEVARKE------LE 443
Query: 957 KQRNRIGCRTIVYWGIGRNRYQLEIPE--------NFTTRNLPEEYELKSTKKGCKRYWT 1008
+RI +++Y I + L IP +F L + L K + T
Sbjct: 444 NLDSRIPSCSVIY--IPLIGFLLSIPRLPSMVEASDFEINGLDFMF-LSEEKLHYRSART 500
Query: 1009 KTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSR 1068
K ++ L +L + E R +L M +L ++ + LDVLL LA+ +R
Sbjct: 501 KELDALLGDL-HCEIRDQETL--LMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAAR 557
Query: 1069 --GGDGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGK 1126
G P P +L + ++ RHP + F+PN G + K
Sbjct: 558 DYGYSRPRYSPQVL-------GVRIQNGRHPLME--LCARTFVPNSTECGGD-------K 601
Query: 1127 AYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSG 1186
++TGPN GKS ++Q GL+ MA +G +VPAE + +D +FTR+ + + I G
Sbjct: 602 GRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLG 661
Query: 1187 ESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKE-LAETIKCRTLF 1245
STF ++L++ A + +ATA SLVL+DE G+GT T DG A+ AV++ LA C +F
Sbjct: 662 LSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIF 721
Query: 1246 -STHYHSLVEDYSQNVAVRLGHMACMVENE-CEDPSQETITFLYKFIKGACPKSYGFNAA 1303
+T++ SLV Q + G + + E CED + + F Y+ +G S+ + A
Sbjct: 722 VATNFLSLV----QLQLLPQGPLVQYLTMETCEDGND--LVFFYQVCEGVAKASHASHTA 775
Query: 1304 RLANLPEEVIQKG 1316
A LP++++ +G
Sbjct: 776 AQAGLPDKLVARG 788
>gi|26638664 mutS homolog 5 isoform b [Homo sapiens]
Length = 835
Score = 138 bits (347), Expect = 4e-32
Identities = 176/670 (26%), Positives = 294/670 (43%), Gaps = 107/670 (15%)
Query: 679 LALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAV 738
L + ALGG + +L + I EL E+Y VS G + +D
Sbjct: 178 LTVRALGGLLKFLGRRRIGVEL------EDY------NVSVPILGFKKFMLTHLVNIDQD 225
Query: 739 TLNNLEIFLNGTN--------GSTEG-TLLERVDTCHTPFGKRLLKQWLCAPLCNHYAIN 789
T + L+IF + ++ G EG +L ++ CH +G++LL+ W P + ++
Sbjct: 226 TYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELS 285
Query: 790 DRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYE--- 846
RLD I+ ++P + ++ ++L RLL I NV LK ++ ++
Sbjct: 286 SRLDVIQ-FFLLPQNL-DMAQML------HRLLGHIKNVPLILKRMKLSHTKVSDWQVLY 337
Query: 847 ETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFK------SKILKQVISLQTKNPEG 900
+T YS + D +L + I + ++A F + ++ +V+ + E
Sbjct: 338 KTVYSALGLRDACRSLP------QSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAEN 391
Query: 901 RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN 960
RF L D D +K R GL L ++ E LE +
Sbjct: 392 RF----TVLPNIDPEIDEKKRRLMGL-----------PSFLTEVARKE------LENLDS 430
Query: 961 RIGCRTIVYWGIGRNRYQLEIPE--------NFTTRNLPEEYELKSTKKGCKRYWTKTIE 1012
RI +++Y I + L IP +F L + L K + TK ++
Sbjct: 431 RIPSCSVIY--IPLIGFLLSIPRLPSMVEASDFEINGLDFMF-LSEEKLHYRSARTKELD 487
Query: 1013 KKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSR--GG 1070
L +L + E R +L M +L ++ + LDVLL LA+ +R G
Sbjct: 488 ALLGDL-HCEIRDQETL--LMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGY 544
Query: 1071 DGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCV 1130
P P +L + ++ RHP + F+PN G + K
Sbjct: 545 SRPRYSPQVL-------GVRIQNGRHPLME--LCARTFVPNSTECGGD-------KGRVK 588
Query: 1131 LVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTF 1190
++TGPN GKS ++Q GL+ MA +G +VPAE + +D +FTR+ + + I G STF
Sbjct: 589 VITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTF 648
Query: 1191 FVELS-ETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKE-LAETIKCRTLF-ST 1247
++L+ + A + +ATA SLVL+DE G+GT T DG A+ AV++ LA C +F +T
Sbjct: 649 MIDLNQQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVAT 708
Query: 1248 HYHSLVEDYSQNVAVRLGHMACMVENE-CEDPSQETITFLYKFIKGACPKSYGFNAARLA 1306
++ SLV Q + G + + E CED + + F Y+ +G S+ + A A
Sbjct: 709 NFLSLV----QLQLLPQGPLVQYLTMETCEDGND--LVFFYQVCEGVAKASHASHTAAQA 762
Query: 1307 NLPEEVIQKG 1316
LP++++ +G
Sbjct: 763 GLPDKLVARG 772
>gi|36949366 mutS homolog 4 [Homo sapiens]
Length = 936
Score = 129 bits (324), Expect = 2e-29
Identities = 106/371 (28%), Positives = 165/371 (44%), Gaps = 51/371 (13%)
Query: 1016 ANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVEC-------IAVLDVLLCLANYSR 1068
A+LI ER SL++ + K + + C +++LD+LL A+
Sbjct: 572 ADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACT 631
Query: 1069 GGD--GPMCRPVILLPEDTPPFLELKGSRHPCITKTFF--GDDFIPNDILIGCEEEEQEN 1124
D P + + + P LE + P T+ G +F+
Sbjct: 632 LSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFL--------------- 676
Query: 1125 GKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIM 1184
++TGPNM GKST ++Q L +MAQ+G YVPAE ++FTR+ D I
Sbjct: 677 ------IITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIE 730
Query: 1185 SGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTL 1244
+ STF E+ E A IL +A SL+L+DELGRGT T +G I AV + L ++K TL
Sbjct: 731 TNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLL-SLKAFTL 789
Query: 1245 FSTHYHSLVEDYSQNVAVRLGHMACM-VENECEDPSQETITFLYKFIKGAC-PKSYGFNA 1302
F+TH+ L + V H V+N ++E I + YK KG K+YG A
Sbjct: 790 FATHFLELCHIDALYPNVENMHFEVQHVKNTSR--NKEAILYTYKLSKGLTEEKNYGLKA 847
Query: 1303 ARLANLPEEV--------------IQKGHRKAREFEKMNQSLRLFREVCLASERSTVDAE 1348
A +++LP + I + R E E+ L + + S +D +
Sbjct: 848 AEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPD 907
Query: 1349 AVHKLLTLIKE 1359
++ L+ +K+
Sbjct: 908 SLRIYLSNLKK 918
Score = 49.3 bits (116), Expect = 3e-05
Identities = 33/125 (26%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Query: 700 LLSMANFEEYIPLDSDTVSTTRSGAI-FTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTL 758
L ++A +Y+ ++V +S I F + Q ++D+ + NLE+ +N + TL
Sbjct: 276 LAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDYRNNHTL 335
Query: 759 LERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDL 818
++ TP G R L+ + PL + IN RLD +++L+ + + ++ + D
Sbjct: 336 FGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDT 395
Query: 819 ERLLS 823
E+LLS
Sbjct: 396 EQLLS 400
>gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]
Length = 1437
Score = 75.9 bits (185), Expect = 3e-13
Identities = 49/157 (31%), Positives = 74/157 (47%), Gaps = 11/157 (7%)
Query: 86 TSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVR-VHVQFFDDSPTRGWVS 144
T F GDLVW+K+ YPWWPC+V + P + + R HVQFF + P R WV
Sbjct: 264 TGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVH 323
Query: 145 KRLLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEP 199
++ ++ Y G K EA K +S K +I + + + A I E A+
Sbjct: 324 EKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKAL---- 379
Query: 200 SEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQ 236
+ EE +E T DK E+ ++++ V KT+
Sbjct: 380 -KMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTE 415
Score = 31.6 bits (70), Expect = 5.4
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 10/106 (9%)
Query: 95 LVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYT-G 153
+VW K+ Y WWP + N I+ + FF S WV + + PY G
Sbjct: 963 IVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEG 1022
Query: 154 SKS---------KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKR 190
KS K +K + + + L+A + + EAL +K R
Sbjct: 1023 DKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSR 1068
>gi|13699813 WHSC1L1 protein isoform short [Homo sapiens]
Length = 645
Score = 75.9 bits (185), Expect = 3e-13
Identities = 49/157 (31%), Positives = 74/157 (47%), Gaps = 11/157 (7%)
Query: 86 TSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVR-VHVQFFDDSPTRGWVS 144
T F GDLVW+K+ YPWWPC+V + P + + R HVQFF + P R WV
Sbjct: 264 TGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVH 323
Query: 145 KRLLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEP 199
++ ++ Y G K EA K +S K +I + + + A I E A+
Sbjct: 324 EKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKAL---- 379
Query: 200 SEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQ 236
+ EE +E T DK E+ ++++ V KT+
Sbjct: 380 -KMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTE 415
>gi|19913356 Wolf-Hirschhorn syndrome candidate 1 protein isoform 3
[Homo sapiens]
Length = 647
Score = 72.0 bits (175), Expect = 4e-12
Identities = 48/166 (28%), Positives = 81/166 (48%), Gaps = 12/166 (7%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKG--KSVR-VHVQFFDDSPTRGWVSKR 146
++ GDLVW+K+ GYPWWPC+V P ++ + KG KS R HVQFF D+P R W+ ++
Sbjct: 220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEK 279
Query: 147 LLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSE 201
L + G +E+ K + K ++L+ + A + I + E A S
Sbjct: 280 SLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAA----SM 335
Query: 202 PEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKK 247
EE + + YV D+ + ++ E + ++ G S + +
Sbjct: 336 SVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSE 381
>gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 72.0 bits (175), Expect = 4e-12
Identities = 48/166 (28%), Positives = 81/166 (48%), Gaps = 12/166 (7%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKG--KSVR-VHVQFFDDSPTRGWVSKR 146
++ GDLVW+K+ GYPWWPC+V P ++ + KG KS R HVQFF D+P R W+ ++
Sbjct: 220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEK 279
Query: 147 LLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSE 201
L + G +E+ K + K ++L+ + A + I + E A S
Sbjct: 280 SLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAA----SM 335
Query: 202 PEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKK 247
EE + + YV D+ + ++ E + ++ G S + +
Sbjct: 336 SVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSE 381
Score = 35.0 bits (79), Expect = 0.49
Identities = 25/124 (20%), Positives = 47/124 (37%), Gaps = 8/124 (6%)
Query: 94 DLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTG 153
D++W K+ Y WWP V + I++ + FF S W + + PY
Sbjct: 882 DIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPY-- 939
Query: 154 SKSKEAQKGGHFYSAK---PEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEV 210
E +G + + A+Q A+ + K++R + +P + ++V
Sbjct: 940 ---MEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKV 996
Query: 211 GTTY 214
Y
Sbjct: 997 NKPY 1000
>gi|6594683 Wolf-Hirschhorn syndrome candidate 1 protein isoform 4
[Homo sapiens]
Length = 629
Score = 72.0 bits (175), Expect = 4e-12
Identities = 48/166 (28%), Positives = 81/166 (48%), Gaps = 12/166 (7%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKG--KSVR-VHVQFFDDSPTRGWVSKR 146
++ GDLVW+K+ GYPWWPC+V P ++ + KG KS R HVQFF D+P R W+ ++
Sbjct: 220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEK 279
Query: 147 LLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSE 201
L + G +E+ K + K ++L+ + A + I + E A S
Sbjct: 280 SLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAA----SM 335
Query: 202 PEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKK 247
EE + + YV D+ + ++ E + ++ G S + +
Sbjct: 336 SVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSE 381
>gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 72.0 bits (175), Expect = 4e-12
Identities = 48/166 (28%), Positives = 81/166 (48%), Gaps = 12/166 (7%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKG--KSVR-VHVQFFDDSPTRGWVSKR 146
++ GDLVW+K+ GYPWWPC+V P ++ + KG KS R HVQFF D+P R W+ ++
Sbjct: 220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEK 279
Query: 147 LLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSE 201
L + G +E+ K + K ++L+ + A + I + E A S
Sbjct: 280 SLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAA----SM 335
Query: 202 PEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKK 247
EE + + YV D+ + ++ E + ++ G S + +
Sbjct: 336 SVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSE 381
Score = 35.0 bits (79), Expect = 0.49
Identities = 25/124 (20%), Positives = 47/124 (37%), Gaps = 8/124 (6%)
Query: 94 DLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTG 153
D++W K+ Y WWP V + I++ + FF S W + + PY
Sbjct: 882 DIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPY-- 939
Query: 154 SKSKEAQKGGHFYSAK---PEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEV 210
E +G + + A+Q A+ + K++R + +P + ++V
Sbjct: 940 ---MEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKV 996
Query: 211 GTTY 214
Y
Sbjct: 997 NKPY 1000
>gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 72.0 bits (175), Expect = 4e-12
Identities = 48/166 (28%), Positives = 81/166 (48%), Gaps = 12/166 (7%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKG--KSVR-VHVQFFDDSPTRGWVSKR 146
++ GDLVW+K+ GYPWWPC+V P ++ + KG KS R HVQFF D+P R W+ ++
Sbjct: 220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEK 279
Query: 147 LLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSE 201
L + G +E+ K + K ++L+ + A + I + E A S
Sbjct: 280 SLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAA----SM 335
Query: 202 PEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKK 247
EE + + YV D+ + ++ E + ++ G S + +
Sbjct: 336 SVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSE 381
Score = 35.0 bits (79), Expect = 0.49
Identities = 25/124 (20%), Positives = 47/124 (37%), Gaps = 8/124 (6%)
Query: 94 DLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTG 153
D++W K+ Y WWP V + I++ + FF S W + + PY
Sbjct: 882 DIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPY-- 939
Query: 154 SKSKEAQKGGHFYSAK---PEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEV 210
E +G + + A+Q A+ + K++R + +P + ++V
Sbjct: 940 ---MEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKV 996
Query: 211 GTTY 214
Y
Sbjct: 997 NKPY 1000
>gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 72.0 bits (175), Expect = 4e-12
Identities = 48/166 (28%), Positives = 81/166 (48%), Gaps = 12/166 (7%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKG--KSVR-VHVQFFDDSPTRGWVSKR 146
++ GDLVW+K+ GYPWWPC+V P ++ + KG KS R HVQFF D+P R W+ ++
Sbjct: 220 YNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEK 279
Query: 147 LLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSE 201
L + G +E+ K + K ++L+ + A + I + E A S
Sbjct: 280 SLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAA----SM 335
Query: 202 PEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKK 247
EE + + YV D+ + ++ E + ++ G S + +
Sbjct: 336 SVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSE 381
Score = 35.0 bits (79), Expect = 0.49
Identities = 25/124 (20%), Positives = 47/124 (37%), Gaps = 8/124 (6%)
Query: 94 DLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTG 153
D++W K+ Y WWP V + I++ + FF S W + + PY
Sbjct: 882 DIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPY-- 939
Query: 154 SKSKEAQKGGHFYSAK---PEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEV 210
E +G + + A+Q A+ + K++R + +P + ++V
Sbjct: 940 ---MEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKV 996
Query: 211 GTTY 214
Y
Sbjct: 997 NKPY 1000
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 54.7 bits (130), Expect = 6e-07
Identities = 78/347 (22%), Positives = 125/347 (36%), Gaps = 77/347 (22%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLK 149
F PGDLV+AKM+GYP WP + + DG K + FF + ++ + L
Sbjct: 5 FKPGDLVFAKMKGYPHWPARI-DDIADGAVKPPPNK----YPIFFFGTHETAFLGPKDLF 59
Query: 150 PYTGSKSK---------------EAQKGGH-FYSAKPEILRAMQRADEALNKDKIKRLEL 193
PY K K E Q H YSA P + + A EA D
Sbjct: 60 PYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPAD------- 112
Query: 194 AVCDEPSEPEEEEEMEVGTTYVTDKSEEDN-EIESEEEVQPKTQGSRRSSRQIKK--RRV 250
++ ++E+ + T VT + D E +S+ + G +R + +K +
Sbjct: 113 ---GSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKR 169
Query: 251 ISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESE---GLNSPVK---VARKRKRMV 304
+ SD+ + V + E SS+ + D E + +P + RK+K+
Sbjct: 170 ARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAP 229
Query: 305 TGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFS----------------------- 341
+ + S + S P A S SS + ++ + S
Sbjct: 230 SASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRG 289
Query: 342 ---APQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRR 385
P+ S + D+ R + W KRRDE RRR
Sbjct: 290 RKPKPERPPSSSSSDSDSDEVDRISEW-----------KRRDEARRR 325
Score = 31.6 bits (70), Expect = 5.4
Identities = 47/235 (20%), Positives = 83/235 (35%), Gaps = 31/235 (13%)
Query: 116 DGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLK--PYTGSKSKEAQKGGHFYSAKPEIL 173
D F EK +VR +P RG + R K P +A G AKPE +
Sbjct: 201 DQDFTPEKKAAVR--------APRRGPLGGRKKKKAPSASDSDSKADSDG----AKPEPV 248
Query: 174 RAMQRADEALNKDKIKRLELAVCDEPS----------EPEEEEEMEVGTTYVTDKSEEDN 223
+ A + + +++V P +P + + + +
Sbjct: 249 AMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSD 308
Query: 224 EIESEEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVG 283
E++ E + + + +RR + ++RR + + + E K +E E G G
Sbjct: 309 EVDRISEWKRRDE-ARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSG 367
Query: 284 DSESEGLNSPVKVARKRKRMVTGNGSLKRKSS------RKETPSATKQATSISSE 332
S + L + +KR R G G S +E + K+ S S+E
Sbjct: 368 GSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTE 422
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 54.7 bits (130), Expect = 6e-07
Identities = 78/347 (22%), Positives = 125/347 (36%), Gaps = 77/347 (22%)
Query: 90 FSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLK 149
F PGDLV+AKM+GYP WP + + DG K + FF + ++ + L
Sbjct: 5 FKPGDLVFAKMKGYPHWPARI-DDIADGAVKPPPNK----YPIFFFGTHETAFLGPKDLF 59
Query: 150 PYTGSKSK---------------EAQKGGH-FYSAKPEILRAMQRADEALNKDKIKRLEL 193
PY K K E Q H YSA P + + A EA D
Sbjct: 60 PYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPAD------- 112
Query: 194 AVCDEPSEPEEEEEMEVGTTYVTDKSEEDN-EIESEEEVQPKTQGSRRSSRQIKK--RRV 250
++ ++E+ + T VT + D E +S+ + G +R + +K +
Sbjct: 113 ---GSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKR 169
Query: 251 ISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESE---GLNSPVK---VARKRKRMV 304
+ SD+ + V + E SS+ + D E + +P + RK+K+
Sbjct: 170 ARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAP 229
Query: 305 TGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFS----------------------- 341
+ + S + S P A S SS + ++ + S
Sbjct: 230 SASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRG 289
Query: 342 ---APQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRR 385
P+ S + D+ R + W KRRDE RRR
Sbjct: 290 RKPKPERPPSSSSSDSDSDEVDRISEW-----------KRRDEARRR 325
Score = 31.6 bits (70), Expect = 5.4
Identities = 47/235 (20%), Positives = 83/235 (35%), Gaps = 31/235 (13%)
Query: 116 DGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLK--PYTGSKSKEAQKGGHFYSAKPEIL 173
D F EK +VR +P RG + R K P +A G AKPE +
Sbjct: 201 DQDFTPEKKAAVR--------APRRGPLGGRKKKKAPSASDSDSKADSDG----AKPEPV 248
Query: 174 RAMQRADEALNKDKIKRLELAVCDEPS----------EPEEEEEMEVGTTYVTDKSEEDN 223
+ A + + +++V P +P + + + +
Sbjct: 249 AMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSD 308
Query: 224 EIESEEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVG 283
E++ E + + + +RR + ++RR + + + E K +E E G G
Sbjct: 309 EVDRISEWKRRDE-ARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSG 367
Query: 284 DSESEGLNSPVKVARKRKRMVTGNGSLKRKSS------RKETPSATKQATSISSE 332
S + L + +KR R G G S +E + K+ S S+E
Sbjct: 368 GSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTE 422
>gi|94721344 zinc finger, CW type with PWWP domain 1 [Homo sapiens]
Length = 648
Score = 53.1 bits (126), Expect = 2e-06
Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 9/81 (11%)
Query: 75 GLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFI----REKGKSVRVH 130
GL VA A+ + PG ++WAK GYPWWP ++ + P G + + H
Sbjct: 305 GLESDVAYAS-----YIPGSIIWAKQYGYPWWPGMIESDPDLGEYFLFTSHLDSLPSKYH 359
Query: 131 VQFFDDSPTRGWVSKRLLKPY 151
V FF ++ +R W+ +LK +
Sbjct: 360 VTFFGETVSRAWIPVNMLKNF 380
>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
[Homo sapiens]
Length = 2427
Score = 52.8 bits (125), Expect = 2e-06
Identities = 59/265 (22%), Positives = 100/265 (37%), Gaps = 35/265 (13%)
Query: 86 TSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVR----VHVQFFDDSPTRG 141
T + GDL+WAK + PWWPC + + P T + K + R +V+ F D R
Sbjct: 48 TPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERA 107
Query: 142 WVSKRLLKPYTG-----------SKSKEAQKGGHFYSAKPEILRAMQRADEALNK--DKI 188
WV+ + + + G + K+ +KG + P+ + + A L + D
Sbjct: 108 WVAGKAIVMFEGRHQFEELPVLRRRGKQKEKG--YRHKVPQKILSKWEASVGLAEQYDVP 165
Query: 189 KRLELAVCDEPS-EPEEEEEMEVGTTYVTDKSEE-------------DNEIESEEEVQPK 234
K + C S + + EE+M +SE D+E ++E+ +P
Sbjct: 166 KGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPC 225
Query: 235 TQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPV 294
+ R S KR + E + E + IS + D+++ N
Sbjct: 226 AKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQAS--NELS 283
Query: 295 KVARKRKRMVTGNGSLKRKSSRKET 319
++A T GS S K T
Sbjct: 284 RIANSLTGSNTAPGSFLFSSCGKNT 308
>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
[Homo sapiens]
Length = 2696
Score = 52.8 bits (125), Expect = 2e-06
Identities = 59/265 (22%), Positives = 100/265 (37%), Gaps = 35/265 (13%)
Query: 86 TSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVR----VHVQFFDDSPTRG 141
T + GDL+WAK + PWWPC + + P T + K + R +V+ F D R
Sbjct: 317 TPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERA 376
Query: 142 WVSKRLLKPYTG-----------SKSKEAQKGGHFYSAKPEILRAMQRADEALNK--DKI 188
WV+ + + + G + K+ +KG + P+ + + A L + D
Sbjct: 377 WVAGKAIVMFEGRHQFEELPVLRRRGKQKEKG--YRHKVPQKILSKWEASVGLAEQYDVP 434
Query: 189 KRLELAVCDEPS-EPEEEEEMEVGTTYVTDKSEE-------------DNEIESEEEVQPK 234
K + C S + + EE+M +SE D+E ++E+ +P
Sbjct: 435 KGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPC 494
Query: 235 TQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPV 294
+ R S KR + E + E + IS + D+++ N
Sbjct: 495 AKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQAS--NELS 552
Query: 295 KVARKRKRMVTGNGSLKRKSSRKET 319
++A T GS S K T
Sbjct: 553 RIANSLTGSNTAPGSFLFSSCGKNT 577
>gi|221316599 chromogranin B precursor [Homo sapiens]
Length = 677
Score = 52.8 bits (125), Expect = 2e-06
Identities = 74/309 (23%), Positives = 109/309 (35%), Gaps = 47/309 (15%)
Query: 112 NHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVS----KRLLKPYTGSKSKEAQKGGHFYS 167
N F+ +R+ + H +S +RG + + P K A+ GGH
Sbjct: 78 NTKFEVRLLRDPADASEAH-----ESSSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRE 132
Query: 168 AKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIES 227
E ++ +D ++++ R E S+ E+EEE E G Y + ED+ E
Sbjct: 133 RADEPQWSLYPSDSQVSEEVKTRHS-----EKSQREDEEEEE-GENYQKGERGEDSSEEK 186
Query: 228 EEEVQPKTQGS----RRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVG 283
E +TQ + R+ + IKK +++ SE+ G E K ++E+ SS E G
Sbjct: 187 HLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQE-KTHSREK-SSQESGEETG 244
Query: 284 DSES-------------------EGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATK 324
E+ E S V R R R G R S PS K
Sbjct: 245 SQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEK 304
Query: 325 QATSISSETKNTLRAFSAPQNSESQAHVSG-------GGDDSSRPTVWYHETLEWLKEEK 377
SE N A + H G + P V E LEW +
Sbjct: 305 GHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRG 364
Query: 378 RRDEHRRRP 386
R E R P
Sbjct: 365 RGSEEYRAP 373
>gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 52.0 bits (123), Expect = 4e-06
Identities = 46/174 (26%), Positives = 77/174 (44%), Gaps = 16/174 (9%)
Query: 89 DFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLL 148
DF PGDL++AKM+GYP WP V P DG K + ++ + FF T ++ + +
Sbjct: 4 DFKPGDLIFAKMKGYPHWPARVDEVP-DGAV---KPPTNKLPIFFFGTHET-AFLGPKDI 58
Query: 149 KPYTGSKSKEAQKGGHFYSAKPEILRAMQRA-DEALNKDKIKRLELAVCDEPSEPEEEEE 207
PY+ +K K KP + E N K+K + S + E
Sbjct: 59 FPYSENKEK---------YGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVE 109
Query: 208 MEVGTTYVTDKSEEDNEIESEEEVQPKTQ-GSRRSSRQIKKRRVISDSESDIGG 260
+E T V+ + + E S E+V + +++R+ +KR+ E++ G
Sbjct: 110 VEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAG 163
>gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo
sapiens]
Length = 333
Score = 52.0 bits (123), Expect = 4e-06
Identities = 46/174 (26%), Positives = 77/174 (44%), Gaps = 16/174 (9%)
Query: 89 DFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLL 148
DF PGDL++AKM+GYP WP V P DG K + ++ + FF T ++ + +
Sbjct: 4 DFKPGDLIFAKMKGYPHWPARVDEVP-DGAV---KPPTNKLPIFFFGTHET-AFLGPKDI 58
Query: 149 KPYTGSKSKEAQKGGHFYSAKPEILRAMQRA-DEALNKDKIKRLELAVCDEPSEPEEEEE 207
PY+ +K K KP + E N K+K + S + E
Sbjct: 59 FPYSENKEK---------YGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVE 109
Query: 208 MEVGTTYVTDKSEEDNEIESEEEVQPKTQ-GSRRSSRQIKKRRVISDSESDIGG 260
+E T V+ + + E S E+V + +++R+ +KR+ E++ G
Sbjct: 110 VEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAG 163
>gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 52.0 bits (123), Expect = 4e-06
Identities = 46/174 (26%), Positives = 77/174 (44%), Gaps = 16/174 (9%)
Query: 89 DFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLL 148
DF PGDL++AKM+GYP WP V P DG K + ++ + FF T ++ + +
Sbjct: 4 DFKPGDLIFAKMKGYPHWPARVDEVP-DGAV---KPPTNKLPIFFFGTHET-AFLGPKDI 58
Query: 149 KPYTGSKSKEAQKGGHFYSAKPEILRAMQRA-DEALNKDKIKRLELAVCDEPSEPEEEEE 207
PY+ +K K KP + E N K+K + S + E
Sbjct: 59 FPYSENKEK---------YGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVE 109
Query: 208 MEVGTTYVTDKSEEDNEIESEEEVQPKTQ-GSRRSSRQIKKRRVISDSESDIGG 260
+E T V+ + + E S E+V + +++R+ +KR+ E++ G
Sbjct: 110 VEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAG 163
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 51.2 bits (121), Expect = 7e-06
Identities = 50/201 (24%), Positives = 88/201 (43%), Gaps = 17/201 (8%)
Query: 122 EKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGS---KSKEAQKGG---HFYSAKPEILRA 175
E+ K R H + D G + + + P+ K KEA++G +S++ + + +
Sbjct: 2163 EESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVES 2222
Query: 176 MQRADEALNK--DKIKRLELAVCDEPSEPEEEEEME---VGTTYVTDKSEEDNE---IES 227
+ E + D++++ E +E E EEEEE E V K EE+ E +E
Sbjct: 2223 EEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEK 2282
Query: 228 EEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSES 287
EEE + K + ++ +K V + E + + E D +EE S + V D E
Sbjct: 2283 EEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEV-DREK 2341
Query: 288 EGL--NSPVKVARKRKRMVTG 306
E L K+ +R++ + G
Sbjct: 2342 EILKKEKQFKLQEQRRKSLRG 2362
>gi|40556376 cytokine-like nuclear factor n-pac [Homo sapiens]
Length = 553
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/167 (24%), Positives = 68/167 (40%), Gaps = 14/167 (8%)
Query: 93 GDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYT 152
GDLVW K+ YP WP + N P D + +GK V+FF + W+ LKPY
Sbjct: 9 GDLVWGKLGRYPPWPGKIVNPPKD--LKKPRGKKC-FFVKFF-GTEDHAWIKVEQLKPYH 64
Query: 153 GSKSK--EAQKGGHFYSAKPEILRAMQRA-------DEALNKDKIKRLELAVCDEPSEPE 203
K + + KG F A + ++RA + DK +R P+ +
Sbjct: 65 AHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGD 124
Query: 204 EEEEMEVGTTYV-TDKSEEDNEIESEEEVQPKTQGSRRSSRQIKKRR 249
E+ ++ + V + E + S + +R+ Q ++R
Sbjct: 125 EKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPLKRAQEQSPRKR 171
>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
Length = 330
Score = 45.4 bits (106), Expect = 4e-04
Identities = 48/175 (27%), Positives = 72/175 (41%), Gaps = 29/175 (16%)
Query: 197 DEPSEPEEEEEMEVGTTYVTDKSEEDNEIE--------SEEEVQPKTQGSRRSSRQIKKR 248
D+ SE EEE+E E + Y D+ E++++ + SEEE K + +RRS + +
Sbjct: 150 DKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSS 209
Query: 249 RVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKRKRMVTGNG 308
S S S S ++ S SS S S +R+R R G
Sbjct: 210 HSRSSSRSSSPSS-------SRSRSRSRSRSSSSSQSRSR------SSSRERSR---SRG 253
Query: 309 SLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSSRPT 363
S R SSR S++ + S SS + + R S++ S GD R T
Sbjct: 254 SKSRSSSRSHRGSSSPRKRSYSSSSSSPER-----NRKRSRSRSSSSGDRKKRRT 303
>gi|7705320 hepatoma-derived growth factor, related protein 3 [Homo
sapiens]
Length = 203
Score = 45.1 bits (105), Expect = 5e-04
Identities = 56/214 (26%), Positives = 86/214 (40%), Gaps = 27/214 (12%)
Query: 83 AAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGW 142
A P ++ GDLV+AKM+GYP WP + P K + + + FF T +
Sbjct: 2 ARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAV----KPPANKYPIFFFGTHET-AF 56
Query: 143 VSKRLLKPYTGSKSK--EAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPS 200
+ + L PY K K ++ K F EI N +K + S
Sbjct: 57 LGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEI----------ENNPGVKFTGYQAIQQQS 106
Query: 201 EPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQ--GSRRSSRQIKKRRVISDSESDI 258
E E E G T EE + +E + + + K + GS+R K+ S +S
Sbjct: 107 --SSETEGEGGNTADASSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKK---SSKQSRK 161
Query: 259 GGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNS 292
D + K +EE S SS GD+ ++ N+
Sbjct: 162 SPGDEDDKDCKEEENKS---SSEGGDAGNDTRNT 192
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 45.1 bits (105), Expect = 5e-04
Identities = 52/216 (24%), Positives = 84/216 (38%), Gaps = 26/216 (12%)
Query: 155 KSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTY 214
KS +KG S P ++A + K ++ + E +EEEE EV
Sbjct: 658 KSPVEEKGKSPVSKSP----VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEV---- 709
Query: 215 VTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGS 274
++ ++ ++E +EE +PK ++ + K +++ + V + +TKEEG
Sbjct: 710 --KEAPKEEKVEKKEE-KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK 766
Query: 275 ------SDEISSGVGDSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATS 328
E + G G SE EG + K +RK V G ++E TK+ S
Sbjct: 767 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNG-----EVEGKEEVEQETKEKGS 821
Query: 329 ISSETKNTLRAFSAPQNSESQAHVSGGGDDSSRPTV 364
E K + S A GGD S V
Sbjct: 822 GREEEKGVV----TNGLDLSPADEKKGGDKSEEKVV 853
Score = 38.5 bits (88), Expect = 0.044
Identities = 37/150 (24%), Positives = 64/150 (42%), Gaps = 22/150 (14%)
Query: 154 SKSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTT 213
S +E ++ +PE + + A K +K V +E E EEEE E
Sbjct: 483 SMKEEKKEAAEEKEEEPEA----EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQE---- 534
Query: 214 YVTDKSEEDNEIESEEEVQPKTQGSRR--SSRQIKKRRVISDSESDIGGSDVEFKPDTKE 271
EE+ E E + Q + GS + SS + + + ++E++ G + E K + K
Sbjct: 535 ------EEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV 588
Query: 272 EGSSDEISSGVGDSESEGLNSPVKVARKRK 301
E S+E+++ E L + KV + K
Sbjct: 589 EEKSEEVAT------KEELVADAKVEKPEK 612
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,605,360
Number of Sequences: 37866
Number of extensions: 2594605
Number of successful extensions: 15628
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 364
Number of HSP's that attempted gapping in prelim test: 13426
Number of HSP's gapped (non-prelim): 1858
length of query: 1360
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1245
effective length of database: 13,892,928
effective search space: 17296695360
effective search space used: 17296695360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.