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Search of human proteins with 4504117
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
(918 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 1859 0.0
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 1719 0.0
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 1409 0.0
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 1407 0.0
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 1337 0.0
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 691 0.0
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 664 0.0
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 612 e-175
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 611 e-174
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 592 e-169
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 591 e-168
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 584 e-166
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 583 e-166
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 582 e-166
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 579 e-165
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 579 e-165
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 375 e-104
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 362 e-100
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 260 5e-69
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 255 2e-67
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 255 2e-67
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 190 6e-48
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 184 3e-46
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 184 3e-46
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 184 3e-46
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 179 1e-44
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 174 3e-43
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 162 1e-39
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 153 6e-37
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p... 136 1e-31
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 1859 bits (4815), Expect = 0.0
Identities = 918/918 (100%), Positives = 918/918 (100%)
Query: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
Sbjct: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
Query: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
Sbjct: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
Query: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
Sbjct: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
Query: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
Sbjct: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
Query: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
Sbjct: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
Query: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
Sbjct: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
Query: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI 420
MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI
Sbjct: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI 420
Query: 421 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 480
WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL
Sbjct: 421 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 480
Query: 481 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 540
DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
Sbjct: 481 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 540
Query: 541 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 600
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
Sbjct: 541 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 600
Query: 601 PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL 660
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
Sbjct: 601 PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL 660
Query: 661 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM 720
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
Sbjct: 661 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM 720
Query: 721 WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG 780
WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
Sbjct: 721 WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG 780
Query: 781 VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI 840
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI
Sbjct: 781 VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI 840
Query: 841 VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECG 900
VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECG
Sbjct: 841 VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECG 900
Query: 901 KLIREERGIRKQSSVHTV 918
KLIREERGIRKQSSVHTV
Sbjct: 901 KLIREERGIRKQSSVHTV 918
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 1719 bits (4451), Expect = 0.0
Identities = 855/873 (97%), Positives = 855/873 (97%), Gaps = 15/873 (1%)
Query: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
Sbjct: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
Query: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
Sbjct: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
Query: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
Sbjct: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
Query: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
Sbjct: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
Query: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
Sbjct: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
Query: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
Sbjct: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
Query: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI 420
MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEK IGI
Sbjct: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEK---------------IGI 405
Query: 421 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 480
WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL
Sbjct: 406 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 465
Query: 481 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 540
DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
Sbjct: 466 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 525
Query: 541 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 600
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
Sbjct: 526 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 585
Query: 601 PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL 660
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
Sbjct: 586 PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL 645
Query: 661 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM 720
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
Sbjct: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM 705
Query: 721 WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG 780
WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
Sbjct: 706 WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG 765
Query: 781 VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI 840
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI
Sbjct: 766 VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI 825
Query: 841 VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCF 873
VLAAGLVLSVFVAIGEFIYKSRKNNDIEQ F
Sbjct: 826 VLAAGLVLSVFVAIGEFIYKSRKNNDIEQCLSF 858
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 1409 bits (3647), Expect = 0.0
Identities = 690/860 (80%), Positives = 774/860 (90%), Gaps = 17/860 (1%)
Query: 15 RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74
R T LL L Q VLR GGIFE VE+ P+ EELAF+FAV +INRNRTL+PN
Sbjct: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
Query: 75 TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134
TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
Query: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194
WKH DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
Query: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254
RYN+++KIRQLP+ KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
Query: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
Query: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
G MTT+AALMYDAV++V++A + Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434
ITFNKTNGLR DFDLD+ISLKEEG EK IG W+ SGLNMT+S K
Sbjct: 374 RITFNKTNGLRTDFDLDVISLKEEGLEK---------------IGTWDPASGLNMTESQK 418
Query: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494
K +NITDSL+NR+LIVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y
Sbjct: 419 GKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTY 478
Query: 495 DVKLVPDGKYGAQND-KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
+++LV DGKYGAQ+D G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGI
Sbjct: 479 EIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538
Query: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD 613
SILYRKPNGTNPGVFSFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPD
Sbjct: 539 SILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPD 598
Query: 614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673
SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF
Sbjct: 599 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 658
Query: 674 LTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALV 733
LTVERMESPIDSADDLAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV
Sbjct: 659 LTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLV 718
Query: 734 RNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKI 793
++++EGIQRVLT+DYA LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKI
Sbjct: 719 KSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKI 778
Query: 794 TIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853
TIAILQLQEEGKLHMMKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA
Sbjct: 779 TIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVA 838
Query: 854 IGEFIYKSRKNNDIE-QAFC 872
+GEF+YKS+KN +E ++FC
Sbjct: 839 VGEFLYKSKKNAQLEKRSFC 858
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 1407 bits (3643), Expect = 0.0
Identities = 688/856 (80%), Positives = 771/856 (90%), Gaps = 16/856 (1%)
Query: 15 RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74
R T LL L Q VLR GGIFE VE+ P+ EELAF+FAV +INRNRTL+PN
Sbjct: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
Query: 75 TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134
TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
Query: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194
WKH DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
Query: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254
RYN+++KIRQLP+ KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
Query: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
Query: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
G MTT+AALMYDAV++V++A + Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434
ITFNKTNGLR DFDLD+ISLKEEG EK IG W+ SGLNMT+S K
Sbjct: 374 RITFNKTNGLRTDFDLDVISLKEEGLEK---------------IGTWDPASGLNMTESQK 418
Query: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494
K +NITDSL+NR+LIVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y
Sbjct: 419 GKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTY 478
Query: 495 DVKLVPDGKYGAQND-KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
+++LV DGKYGAQ+D G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGI
Sbjct: 479 EIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538
Query: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD 613
SILYRKPNGTNPGVFSFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPD
Sbjct: 539 SILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPD 598
Query: 614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673
SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF
Sbjct: 599 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 658
Query: 674 LTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALV 733
LTVERMESPIDSADDLAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV
Sbjct: 659 LTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLV 718
Query: 734 RNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKI 793
++++EGIQRVLT+DYA LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKI
Sbjct: 719 KSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKI 778
Query: 794 TIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853
TIAILQLQEEGKLHMMKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA
Sbjct: 779 TIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVA 838
Query: 854 IGEFIYKSRKNNDIEQ 869
+GEF+YKS+KN +E+
Sbjct: 839 VGEFLYKSKKNAQLEK 854
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 1337 bits (3461), Expect = 0.0
Identities = 648/860 (75%), Positives = 751/860 (87%), Gaps = 22/860 (2%)
Query: 19 WALLYFLCYILPQTA--PQVLRIGGIFETVEN---EPVNVEELAFKFAVTSINRNRTLMP 73
WA L + +P + P V+RIGGIFE + + +N EE AF+F+ INRNRTL+P
Sbjct: 16 WAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLP 75
Query: 74 NTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 133
NTTLTYDIQRI+ DSFEA+++ACDQLALGV A+FGPS S +AVQSICNALEVPHIQ
Sbjct: 76 NTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQL 135
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAP 193
RWKH +DNKD FY+NLYPDYA++S AILDLV Y W++ TVVY+DSTGLIRLQELI AP
Sbjct: 136 RWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAP 195
Query: 194 SRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYY 253
SRYNI++KIRQLP + D++PLLKEMK+G+EF +IFDCSH AA+ILKQ + MGMMTEYY
Sbjct: 196 SRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYY 255
Query: 254 HYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLL 313
H+ FTTLDL+ALDLE YRYSGVN+TGFR+LN+DNPHVS+I+EKWSMERLQA PR E+GLL
Sbjct: 256 HFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLL 315
Query: 314 DGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLT 373
DG+M T+AAL+YDAV++V++ RA Q+TV+SLQCHRHK WR G RFMN IKEA+W+GLT
Sbjct: 316 DGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLT 375
Query: 374 GHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSN 433
G I FNKT+GLR DFDLDIISLKE+G EK +G+W+ GLN+T+
Sbjct: 376 GRIVFNKTSGLRTDFDLDIISLKEDGLEK---------------VGVWSPADGLNITEVA 420
Query: 434 KDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFI 493
K + N+TDSL NR+LIVTT+LEEP+VM+RKSD+ LYGNDRFEGYC+DLLKEL++ILGF
Sbjct: 421 KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS 480
Query: 494 YDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
Y+++LV DGKYGAQ+DKG+WNGMVKELIDH+ADLAVAPLTIT+VREK IDFSKPFMTLG+
Sbjct: 481 YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV 540
Query: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD 613
SILYRKPNGTNP VFSFLNPLSPDIWMYVLLA LGVSCVLFVIARF+PYEWY+ HPCNP
Sbjct: 541 SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG 600
Query: 614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673
S+VVENNFTLLNSFWFG+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAF
Sbjct: 601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660
Query: 674 LTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALV 733
LTVERMESPIDSADDLAKQTKIEYGAV+DG+TMTFFKKSKIST+EKMWAFMSS+ +ALV
Sbjct: 661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALV 719
Query: 734 RNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKI 793
+N++EGIQR LT DYALLMEST+IEYVTQRNCNLTQIGGLIDSKGYG+GTP+GSPYRDKI
Sbjct: 720 KNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKI 779
Query: 794 TIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853
TIAILQLQEE KLH+MKEKWWRG+GCPEE+NKEASALG++ IGGIFIVLAAGLVLSV VA
Sbjct: 780 TIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVA 839
Query: 854 IGEFIYKSRKNNDIEQ-AFC 872
+GEF+YK RK + EQ +FC
Sbjct: 840 VGEFVYKLRKTAEREQRSFC 859
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 691 bits (1783), Expect = 0.0
Identities = 372/825 (45%), Positives = 516/825 (62%), Gaps = 35/825 (4%)
Query: 54 EELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHS 113
E LA A IN + + DI + +E + C L GV ++ GPS S
Sbjct: 40 ERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSS 99
Query: 114 -SSVSAVQSICNALEVPHIQTRWKH-PSVDNKDLFYINLYPDYAAISRAILDLVLYYNWK 171
+S S V IC E+PHI+ + P + ++LYP +S A+ ++ +N+
Sbjct: 100 PASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYP 159
Query: 172 TVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDC 231
+ +++ + L+RL+EL++ + +R L ++D PLLKE++ K +I D
Sbjct: 160 SASLICAKAECLLRLEELVRGFLISKETLSVRMLDD-SRDPTPLLKEIRDDKVSTIIIDA 218
Query: 232 SHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVS 291
+ + IL++ +GM + +Y Y TT+D L L+ N+ GF + N +P
Sbjct: 219 NASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYP 278
Query: 292 SIIEKWSM---ERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIAS---HRASQLTVSS 345
+ +M E +A L AALM+DAV++V A +R+ ++ V
Sbjct: 279 EFVRSLNMSWRENCEASTYLGPAL-------SAALMFDAVHVVVSAVRELNRSQEIGVKP 331
Query: 346 LQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAG 405
L C W G MN ++ +DGLTG + FN + G R ++ L I+ +G
Sbjct: 332 LACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFN-SKGQRTNYTLRILEKSRQGH----- 385
Query: 406 EVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKS 465
++IG+W SN L M + D N++ +LAN+TL+VTTILE PYVM R +
Sbjct: 386 ----------REIGVWYSNRTLAMNATTLD--INLSQTLANKTLVVTTILENPYVMRRPN 433
Query: 466 DKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRA 525
+ L GN+RFEG+C+D+L+EL+ +L F Y ++LV DG YGA G W GMV ELI+ +A
Sbjct: 434 FQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKA 493
Query: 526 DLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLA 585
DLAVA TIT REKVIDFSKPFMTLGISILYR G PG FSFL+P SP +W+++LLA
Sbjct: 494 DLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLA 553
Query: 586 CLGVSCVLFVIARFTPYEWYNPHPC-NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPK 644
L VSCVLF+ AR +PYEWYNPHPC ++EN +TL NS WF VG MQQGSE+MP+
Sbjct: 554 YLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPR 613
Query: 645 ALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGS 704
ALSTR V G+WW FTLIIISSYTANLAAFLTV+RME P++SADDLA QT IEYG + GS
Sbjct: 614 ALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGS 673
Query: 705 TMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRN 764
TMTFF+ S+ TY++MW +M S+Q + V++++EGI RVL + YA L+EST EY + N
Sbjct: 674 TMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLN 733
Query: 765 CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDN 824
CNLTQIGGL+D+KGYG+G P+GSP+RD+IT+AILQLQE +L ++K KWW G CP+E++
Sbjct: 734 CNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEED 793
Query: 825 KEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQ 869
A LG+ENIGGIFIVL GL+++VFVA+ EFI+ +R++ + E+
Sbjct: 794 HRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEE 838
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 664 bits (1712), Expect = 0.0
Identities = 368/855 (43%), Positives = 518/855 (60%), Gaps = 38/855 (4%)
Query: 28 ILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLF 87
++ +P LRI I + E E L+ A INR + + DI +
Sbjct: 16 VMVACSPHSLRIAAILDD-PMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRD 74
Query: 88 DSFEASRRACDQLALGVAALFGPSHS-SSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
+E + C L GV A+ GPS S +S S + +IC EVPH + P K F
Sbjct: 75 SEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVA---PEEFVKFQF 131
Query: 147 Y----INLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKI 202
+NL+P IS A+ ++ ++N T ++ + L+ L++L++ + +
Sbjct: 132 QRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSV 191
Query: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
R L +D PLLKE++ K +I + + IL + +GM++ YY Y FT L+
Sbjct: 192 RMLDD-TRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEF 250
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME-RLQAPPRPETGLLDGMMTTEA 321
++ VN+ GF + N + + + + P TG +
Sbjct: 251 SLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG-----PALSS 305
Query: 322 ALMYDAVYMVAIAS---HRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITF 378
AL++DAVY V A +R+ ++ V L C + W+ G MN ++ +GLTGHI F
Sbjct: 306 ALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEF 365
Query: 379 NKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSS 438
N + G R ++ L I+ G +++IG W+ GL+M DS+ +S
Sbjct: 366 N-SKGQRSNYALKILQFTRNG---------------FRQIGQWHVAEGLSM-DSHL-YAS 407
Query: 439 NITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKL 498
NI+D+L N TL+VTTILE PY+M + + + + GNDR+EG+C+D+LKEL+ IL F Y ++L
Sbjct: 408 NISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRL 467
Query: 499 VPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYR 558
V DG YG G W GMV ELI +ADLAVA LTIT REKVIDFSKPFMTLGISILYR
Sbjct: 468 VGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYR 527
Query: 559 KPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS-DVV 617
G PG FSFL+P SP +W+++LLA L VSCVLF++AR TPYEWY+PHPC +++
Sbjct: 528 VHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLL 587
Query: 618 ENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVE 677
N ++L NS WF VG MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+
Sbjct: 588 VNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQ 647
Query: 678 RMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSD 737
RM+ PI+S DDLA QT IEYG + GS+MTFF+ S+ TY++MW +M S+Q + V++++
Sbjct: 648 RMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTE 707
Query: 738 EGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797
EGI RVL ++YA L+EST EY QRNCNLTQIGGL+D+KGYG+G P+GS +RD+ +AI
Sbjct: 708 EGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAI 767
Query: 798 LQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEF 857
LQLQE +L ++K KWW G CP+E++ A LG+ENIGGIF+VL GL++++F+A+ EF
Sbjct: 768 LQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEF 827
Query: 858 IYKSRKNNDIEQAFC 872
++ R + E + C
Sbjct: 828 LWTLRHSEATEVSVC 842
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 612 bits (1579), Expect = e-175
Identities = 352/908 (38%), Positives = 533/908 (58%), Gaps = 62/908 (6%)
Query: 24 FLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQR 83
FL ++ P ++IGG+F +++ E AF+FA++ + L+P I
Sbjct: 12 FLGAVVGANFPNNIQIGGLFPNQQSQ----EHAAFRFALSQLTEPPKLLPQ------IDI 61
Query: 84 INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK 143
+N+ DSFE + R C Q + GV A+FG +V+ + S C AL V I + VD
Sbjct: 62 VNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTS 118
Query: 144 DLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIK-I 202
+ F + L P+ + A++ ++ +Y W+ +Y+ GL LQ+++ + N ++ +
Sbjct: 119 NQFVLQLRPE---LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAV 175
Query: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
L + + + L ++++K KE V+ DC E IL QI+ + YHY L
Sbjct: 176 NILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGF 235
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+DL ++ SG N+TGF+L+N + + I+++W + R T + +A
Sbjct: 236 MDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWK----NSDARDHTRVDWKRPKYTSA 291
Query: 323 LMYDAVYMVAIA--SHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L YD V ++A A S R ++ +S + PW G +++ R++GLTG
Sbjct: 292 LTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTG 351
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434
++ FN+ G R ++ L +I +K +G +KIG WN + + +
Sbjct: 352 NVQFNE-KGRRTNYTLHVIEMKHDGI---------------RKIGYWNEDDKF-VPAATD 394
Query: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494
++ S+ NRT IVTTILE+PYVM +K+ GNDR+EGYC++L E++ +G+ Y
Sbjct: 395 AQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSY 454
Query: 495 DVKLVPDGKYGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
+++V DGKYGA++ D WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGI
Sbjct: 455 RLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGI 514
Query: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PC 610
SI+ +KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW++
Sbjct: 515 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGR 574
Query: 611 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 670
+ + N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANL
Sbjct: 575 DQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 634
Query: 671 AAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQT 730
AAFLTVERM SPI+SA+DLAKQT+I YG + GST FF++SKI+ +EKMW +M S + +
Sbjct: 635 AAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPS 694
Query: 731 ALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGS 787
VR ++EG+ RV + YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS
Sbjct: 695 VFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS 754
Query: 788 PYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLA 843
R + +A+L+L E+G L +K KWW G C +D+ + SAL + N+ G+F +L
Sbjct: 755 ALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILI 814
Query: 844 AGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQ-----THPTNSTSGTTLSTDLE 898
GL L++ VA+ EF YKSR + + FC + T P NS +G + E
Sbjct: 815 GGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGE 874
Query: 899 CGKLIREE 906
G+++ +
Sbjct: 875 NGRVVSHD 882
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 611 bits (1575), Expect = e-174
Identities = 351/908 (38%), Positives = 532/908 (58%), Gaps = 62/908 (6%)
Query: 24 FLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQR 83
FL ++ P ++IGG+F +++ E AF+FA++ + L+P I
Sbjct: 12 FLGAVVGANFPNNIQIGGLFPNQQSQ----EHAAFRFALSQLTEPPKLLPQ------IDI 61
Query: 84 INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK 143
+N+ DSFE + R C Q + GV A+FG +V+ + S C AL V I + VD
Sbjct: 62 VNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTS 118
Query: 144 DLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIK-I 202
+ F + L P+ + A++ ++ +Y W+ +Y+ GL LQ+++ + N ++ +
Sbjct: 119 NQFVLQLRPE---LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAV 175
Query: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
L + + + L ++++K KE V+ DC E IL QI+ + YHY L
Sbjct: 176 NILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGF 235
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+DL ++ SG N+TGF+L+N + + I+++W + R T + +A
Sbjct: 236 MDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWK----NSDARDHTRVDWKRPKYTSA 291
Query: 323 LMYDAVYMVAIA--SHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L YD V ++A A S R ++ +S + PW G +++ R++GLTG
Sbjct: 292 LTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTG 351
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434
++ FN+ G R ++ L +I +K +G +KIG WN + + +
Sbjct: 352 NVQFNE-KGRRTNYTLHVIEMKHDGI---------------RKIGYWNEDDKF-VPAATD 394
Query: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494
++ S+ NRT IVTTILE+PYVM +K+ GNDR+EGYC++L E++ +G+ Y
Sbjct: 395 AQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSY 454
Query: 495 DVKLVPDGKYGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
+++V DGKYGA++ D WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGI
Sbjct: 455 RLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGI 514
Query: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PC 610
SI+ +KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW++
Sbjct: 515 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGR 574
Query: 611 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 670
+ + N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANL
Sbjct: 575 DQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 634
Query: 671 AAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQT 730
AAFLTVERM SPI+SA+DLAKQT+I YG + GST FF++SKI+ +EKMW +M S + +
Sbjct: 635 AAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPS 694
Query: 731 ALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGS 787
VR ++EG+ RV + YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS
Sbjct: 695 VFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS 754
Query: 788 PYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EDNKEASALGVENIGGIFIVLA 843
R+ + +A+L+L E+G L +K KWW G C + + SAL + N+ G+F +L
Sbjct: 755 ALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILI 814
Query: 844 AGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQ-----THPTNSTSGTTLSTDLE 898
GL L++ VA+ EF YKSR + + FC + T P NS +G + E
Sbjct: 815 GGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGE 874
Query: 899 CGKLIREE 906
G+++ +
Sbjct: 875 NGRVVSHD 882
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 592 bits (1525), Expect = e-169
Identities = 348/861 (40%), Positives = 508/861 (59%), Gaps = 72/861 (8%)
Query: 34 PQVLRIGGIF--ETVENEPVNVEELAFKFAVTSINRNRTLMPNTT-----LTYDIQRINL 86
P + IGG+F TV+ E AF+FAV N N+ NTT L Y + ++
Sbjct: 31 PNTISIGGLFMRNTVQ------EHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVDHLDS 80
Query: 87 FDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
+SF + C Q + GV A+FG S++ + S C AL + + D F
Sbjct: 81 SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP---TDADVQF 137
Query: 147 YINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLP 206
I + P A+ AIL L+ +Y W+ +Y+ G LQ +++A + N ++ R +
Sbjct: 138 VIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSV- 193
Query: 207 SGN----KDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
GN ++ + +++EM + +E + DC E IL+Q++ +G + YHY L
Sbjct: 194 -GNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGF 252
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+ LE + G N+TGF+++N +NP V I++W RL PE + + +A
Sbjct: 253 TDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV--RLDEREFPEAK--NAPLKYTSA 308
Query: 323 LMYDAVYMVAIASH--RASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L +DA+ ++A A R ++ VS + PW G +K + G+TG
Sbjct: 309 LTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTG 368
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434
+I F+ T G R ++ +D+ +K G+ KA G WN +
Sbjct: 369 NIQFD-TYGRRTNYTIDVYEMKVSGSRKA---------------GYWNEYE--RFVPFSD 410
Query: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494
+ SN + S NRT++VTTILE PYVMY+K+ + L GN+R+EGYC+DL E++ + Y
Sbjct: 411 QQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKY 470
Query: 495 DVKLVPDGKYGAQNDKGE-WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
+ +V DGKYGA++ + + WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGI
Sbjct: 471 KLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGI 530
Query: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWY----NPHP 609
SI+ +KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ N P
Sbjct: 531 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEP 590
Query: 610 CNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 668
+P S N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTA
Sbjct: 591 RDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 650
Query: 669 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQ 728
NLAAFLTVERM SPI+SA+DLAKQT+I YG + GST FF++SKI+ YEKMW++M S +
Sbjct: 651 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAE 710
Query: 729 QTALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPI 785
+ + + +G+ RV + +A L+EST EY+ QR C+ ++GG +DSKGYGV TP
Sbjct: 711 PSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK 770
Query: 786 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIV 841
GS + +A+L+L E+G L +K KWW G C +D+ + SAL + N+ G+F +
Sbjct: 771 GSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYI 830
Query: 842 LAAGLVLSVFVAIGEFIYKSR 862
L GL L++ VA+ EF YKSR
Sbjct: 831 LVGGLGLAMMVALIEFCYKSR 851
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 591 bits (1523), Expect = e-168
Identities = 347/861 (40%), Positives = 507/861 (58%), Gaps = 72/861 (8%)
Query: 34 PQVLRIGGIF--ETVENEPVNVEELAFKFAVTSINRNRTLMPNTT-----LTYDIQRINL 86
P + IGG+F TV+ E AF+FAV N N+ NTT L Y + ++
Sbjct: 31 PNTISIGGLFMRNTVQ------EHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVDHLDS 80
Query: 87 FDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
+SF + C Q + GV A+FG S++ + S C AL + + D F
Sbjct: 81 SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP---TDADVQF 137
Query: 147 YINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLP 206
I + P A+ AIL L+ +Y W+ +Y+ G LQ +++A + N ++ R +
Sbjct: 138 VIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSV- 193
Query: 207 SGN----KDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
GN ++ + +++EM + +E + DC E IL+Q++ +G + YHY L
Sbjct: 194 -GNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGF 252
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+ LE + G N+TGF+++N +NP V I++W RL PE + + +A
Sbjct: 253 TDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV--RLDEREFPEAK--NAPLKYTSA 308
Query: 323 LMYDAVYMVAIASH--RASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L +DA+ ++A A R ++ VS + PW G +K + G+TG
Sbjct: 309 LTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTG 368
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434
+I F+ T G R ++ +D+ +K G+ KA G WN +
Sbjct: 369 NIQFD-TYGRRTNYTIDVYEMKVSGSRKA---------------GYWNEYE--RFVPFSD 410
Query: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494
+ SN + S NRT++VTTILE PYVMY+K+ + L GN+R+EGYC+DL E++ + Y
Sbjct: 411 QQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKY 470
Query: 495 DVKLVPDGKYGAQNDKGE-WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
+ +V DGKYGA++ + + WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGI
Sbjct: 471 KLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGI 530
Query: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWY----NPHP 609
SI+ +KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ N P
Sbjct: 531 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEP 590
Query: 610 CNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 668
+P S N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTA
Sbjct: 591 RDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 650
Query: 669 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQ 728
NLAAFLTVERM SPI+SA+DLAKQT+I YG + GST FF++SKI+ YEKMW++M S +
Sbjct: 651 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAE 710
Query: 729 QTALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPI 785
+ + + +G+ RV + +A L+EST EY+ QR C+ ++GG +DSKGYGV TP
Sbjct: 711 PSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK 770
Query: 786 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EDNKEASALGVENIGGIFIV 841
GS + + +A+L+L E+G L +K KWW G C + + SAL + N+ G+F +
Sbjct: 771 GSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYI 830
Query: 842 LAAGLVLSVFVAIGEFIYKSR 862
L GL L++ VA+ EF YKSR
Sbjct: 831 LVGGLGLAMMVALIEFCYKSR 851
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 584 bits (1505), Expect = e-166
Identities = 337/854 (39%), Positives = 500/854 (58%), Gaps = 68/854 (7%)
Query: 37 LRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRA 96
++IGG+F ++ E AF+ + + + LT I + + +SF +
Sbjct: 27 IQIGGLFPRGADQ----EYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAF 77
Query: 97 CDQLALGVAALFGPSHSSSVSAVQSICNALEV----PHIQTRWKHPSVDNKDLFYINLYP 152
C Q + GV A+FG SV+ + S C L V P T HP F I + P
Sbjct: 78 CSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHP-------FVIQMRP 130
Query: 153 DYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA 212
D + A+L L+ YY W +Y+ GL LQ ++ + + ++ + + N D
Sbjct: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187
Query: 213 KP-----LLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL 267
K L ++++ KE VI DC + +I+ Q++ +G + YHY L DL
Sbjct: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247
Query: 268 ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDA 327
++ G N++GF++++ D+ VS IE+WS + P T + +AL YDA
Sbjct: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIK----YTSALTYDA 303
Query: 328 VYMV--AIASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFN 379
V ++ A + R ++ +S + PW G +K+ + +GL+G+I F+
Sbjct: 304 VQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFD 363
Query: 380 KTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSN 439
+ NG R ++ ++I+ LK G +KIG W+ + +T + S N
Sbjct: 364 Q-NGKRINYTINIMELKTNGP---------------RKIGYWSEVDKMVVTLTELP-SGN 406
Query: 440 ITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLV 499
T L N+T++VTTILE PYVM +K+ + L GN+R+EGYC+DL E++ GF Y + +V
Sbjct: 407 DTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV 466
Query: 500 PDGKYGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYR 558
DGKYGA++ D WNGMV EL+ +AD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +
Sbjct: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526
Query: 559 KPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PCNPDSD 615
KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ S
Sbjct: 527 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS 586
Query: 616 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 675
N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLT
Sbjct: 587 ESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 646
Query: 676 VERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN 735
VERM SPI+SA+DL+KQT+I YG + GST FF++SKI+ ++KMW +M S + + VR
Sbjct: 647 VERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRT 706
Query: 736 SDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDK 792
+ EG+ RV + YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R
Sbjct: 707 TAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTP 766
Query: 793 ITIAILQLQEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLAAGLVL 848
+ +A+L+L E+G L +K KWW G C +D+ ++ SAL + N+ G+F +L GL L
Sbjct: 767 VNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGL 826
Query: 849 SVFVAIGEFIYKSR 862
++ VA+ EF YKSR
Sbjct: 827 AMLVALIEFCYKSR 840
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 583 bits (1502), Expect = e-166
Identities = 336/854 (39%), Positives = 499/854 (58%), Gaps = 68/854 (7%)
Query: 37 LRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRA 96
++IGG+F ++ E AF+ + + + LT I + + +SF +
Sbjct: 27 IQIGGLFPRGADQ----EYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAF 77
Query: 97 CDQLALGVAALFGPSHSSSVSAVQSICNALEV----PHIQTRWKHPSVDNKDLFYINLYP 152
C Q + GV A+FG SV+ + S C L V P T HP F I + P
Sbjct: 78 CSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHP-------FVIQMRP 130
Query: 153 DYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA 212
D + A+L L+ YY W +Y+ GL LQ ++ + + ++ + + N D
Sbjct: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187
Query: 213 KP-----LLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL 267
K L ++++ KE VI DC + +I+ Q++ +G + YHY L DL
Sbjct: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247
Query: 268 ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDA 327
++ G N++GF++++ D+ VS IE+WS + P T + +AL YDA
Sbjct: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIK----YTSALTYDA 303
Query: 328 VYMV--AIASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFN 379
V ++ A + R ++ +S + PW G +K+ + +GL+G+I F+
Sbjct: 304 VQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFD 363
Query: 380 KTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSN 439
+ NG R ++ ++I+ LK G +KIG W+ + +T + S N
Sbjct: 364 Q-NGKRINYTINIMELKTNGP---------------RKIGYWSEVDKMVVTLTELP-SGN 406
Query: 440 ITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLV 499
T L N+T++VTTILE PYVM +K+ + L GN+R+EGYC+DL E++ GF Y + +V
Sbjct: 407 DTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV 466
Query: 500 PDGKYGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYR 558
DGKYGA++ D WNGMV EL+ +AD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +
Sbjct: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526
Query: 559 KPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PCNPDSD 615
KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ S
Sbjct: 527 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS 586
Query: 616 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 675
N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLT
Sbjct: 587 ESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 646
Query: 676 VERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN 735
VERM SPI+SA+DL+KQT+I YG + GST FF++SKI+ ++KMW +M S + + VR
Sbjct: 647 VERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRT 706
Query: 736 SDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDK 792
+ EG+ RV + YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R+
Sbjct: 707 TAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNA 766
Query: 793 ITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EDNKEASALGVENIGGIFIVLAAGLVL 848
+ +A+L+L E+G L +K KWW G C + ++ SAL + N+ G+F +L GL L
Sbjct: 767 VNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGL 826
Query: 849 SVFVAIGEFIYKSR 862
++ VA+ EF YKSR
Sbjct: 827 AMLVALIEFCYKSR 840
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 582 bits (1501), Expect = e-166
Identities = 330/814 (40%), Positives = 484/814 (59%), Gaps = 59/814 (7%)
Query: 77 LTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEV----PHIQ 132
LT I + + +SF + C Q + GV A+FG SV+ + S C L V P
Sbjct: 11 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP 70
Query: 133 TRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKA 192
T HP F I + PD + A+L L+ YY W +Y+ GL LQ ++ +
Sbjct: 71 TDGTHP-------FVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDS 120
Query: 193 PSRYNIKIKIRQLPSGNKDAKP-----LLKEMKKGKEFYVIFDCSHETAAEILKQILFMG 247
+ ++ + + N D K L ++++ KE VI DC + +I+ Q++ +G
Sbjct: 121 AAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIG 180
Query: 248 MMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPR 307
+ YHY L DL ++ G N++GF++++ D+ VS IE+WS + P
Sbjct: 181 KHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPG 240
Query: 308 PETGLLDGMMTTEAALMYDAVYMV--AIASHRASQLTVS------SLQCHRHKPWRLGPR 359
T + +AL YDAV ++ A + R ++ +S + PW G
Sbjct: 241 AHTTTIK----YTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVE 296
Query: 360 FMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIG 419
+K+ + +GL+G+I F++ NG R ++ ++I+ LK G +KIG
Sbjct: 297 IERALKQVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGP---------------RKIG 340
Query: 420 IWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYC 479
W+ + +T + S N T L N+T++VTTILE PYVM +K+ + L GN+R+EGYC
Sbjct: 341 YWSEVDKMVVTLTELP-SGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYC 399
Query: 480 LDLLKELSNILGFIYDVKLVPDGKYGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVR 538
+DL E++ GF Y + +V DGKYGA++ D WNGMV EL+ +AD+A+APLTIT VR
Sbjct: 400 VDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVR 459
Query: 539 EKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIAR 598
E+VIDFSKPFM+LGISI+ +KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++R
Sbjct: 460 EEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 519
Query: 599 FTPYEWYNPH---PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIW 655
F+PYEW+ S N F + NS WF +GA M+QG ++ P++LS RIVGG+W
Sbjct: 520 FSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVW 579
Query: 656 WFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIS 715
WFFTLIIISSYTANLAAFLTVERM SPI+SA+DL+KQT+I YG + GST FF++SKI+
Sbjct: 580 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA 639
Query: 716 TYEKMWAFMSSRQQTALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGG 772
++KMW +M S + + VR + EG+ RV + YA L+EST EY+ QR C+ ++GG
Sbjct: 640 VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGG 699
Query: 773 LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEDN---KEAS 828
+DSKGYG+ TP GS R + +A+L+L E+G L +K KWW G C +D+ ++ S
Sbjct: 700 NLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTS 759
Query: 829 ALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 862
AL + N+ G+F +L GL L++ VA+ EF YKSR
Sbjct: 760 ALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 793
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 579 bits (1493), Expect = e-165
Identities = 332/849 (39%), Positives = 491/849 (57%), Gaps = 51/849 (6%)
Query: 34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEAS 93
P ++IGG+F ++ LA TS N + L + I +SF +
Sbjct: 24 PSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF---NLVPHVDNIETANSFAVT 80
Query: 94 RRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPD 153
C Q + GV A+FG SV + S C+AL + I + + + F + L P
Sbjct: 81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP---TEGESQFVLQLRP- 136
Query: 154 YAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA- 212
++ A+L L+ +Y W +Y+ G LQ +++ + + + + N +
Sbjct: 137 --SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSY 194
Query: 213 KPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRY 272
+ LL+E+ + +E + DC E IL+QI+ +G + YHY L + LE + +
Sbjct: 195 RQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIH 254
Query: 273 SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVA 332
G N+TGF+L++ + P V ++++W + P ET +AL YD V ++A
Sbjct: 255 GGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETP-----PKYTSALTYDGVLVMA 309
Query: 333 --IASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL 384
S R ++ +S + PW G +K+ R GLTG++ F+ G
Sbjct: 310 ETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHY-GR 368
Query: 385 RKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSL 444
R ++ +D+ LK G +K+G WN L + + N T ++
Sbjct: 369 RVNYTMDVFELKSTGP---------------RKVGYWNDMDKLVLIQ-DVPTLGNDTAAI 412
Query: 445 ANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKY 504
NRT++VTTI+E PYVMY+K+ + GND++EGYC+DL E++ +G Y + +VPDGKY
Sbjct: 413 ENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKY 472
Query: 505 GAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGT 563
GA++ D WNGMV EL+ +A++A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP +
Sbjct: 473 GARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 532
Query: 564 NPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD---SDVVENN 620
PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ P + SD N
Sbjct: 533 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNE 592
Query: 621 FTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERME 680
F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM
Sbjct: 593 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 652
Query: 681 SPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGI 740
SPI+SA+DLAKQT+I YG + GST FF++SKI+ YEKMW +M S + + R + EG+
Sbjct: 653 SPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGV 712
Query: 741 QRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797
RV + +A L+EST EY+ QR C+ ++GG +DSKGYGV TP GS + + +A+
Sbjct: 713 ARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAV 772
Query: 798 LQLQEEGKLHMMKEKWWRGNG-CPE---EDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853
L+L E+G L +K KWW G C + + SAL + N+ G+F +L GL L++ VA
Sbjct: 773 LKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVA 832
Query: 854 IGEFIYKSR 862
+ EF YKSR
Sbjct: 833 LIEFCYKSR 841
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 579 bits (1493), Expect = e-165
Identities = 333/849 (39%), Positives = 491/849 (57%), Gaps = 51/849 (6%)
Query: 34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEAS 93
P ++IGG+F ++ LA TS N + L + I +SF +
Sbjct: 24 PSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF---NLVPHVDNIETANSFAVT 80
Query: 94 RRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPD 153
C Q + GV A+FG SV + S C+AL + I + + + F + L P
Sbjct: 81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP---TEGESQFVLQLRP- 136
Query: 154 YAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA- 212
++ A+L L+ +Y W +Y+ G LQ +++ + + + + N +
Sbjct: 137 --SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSY 194
Query: 213 KPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRY 272
+ LL+E+ + +E + DC E IL+QI+ +G + YHY L + LE + +
Sbjct: 195 RQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIH 254
Query: 273 SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVA 332
G N+TGF+L++ + P V ++++W + P ET +AL YD V ++A
Sbjct: 255 GGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETP-----PKYTSALTYDGVLVMA 309
Query: 333 --IASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL 384
S R ++ +S + PW G +K+ R GLTG++ F+ G
Sbjct: 310 ETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHY-GR 368
Query: 385 RKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSL 444
R ++ +D+ LK G +K+G WN L + + N T ++
Sbjct: 369 RVNYTMDVFELKSTGP---------------RKVGYWNDMDKLVLIQ-DVPTLGNDTAAI 412
Query: 445 ANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKY 504
NRT++VTTI+E PYVMY+K+ + GND++EGYC+DL E++ +G Y + +VPDGKY
Sbjct: 413 ENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKY 472
Query: 505 GAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGT 563
GA++ D WNGMV EL+ +A++A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP +
Sbjct: 473 GARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 532
Query: 564 NPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD---SDVVENN 620
PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ P + SD N
Sbjct: 533 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNE 592
Query: 621 FTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERME 680
F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM
Sbjct: 593 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 652
Query: 681 SPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGI 740
SPI+SA+DLAKQT+I YG + GST FF++SKI+ YEKMW +M S + + R + EG+
Sbjct: 653 SPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGV 712
Query: 741 QRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797
RV + +A L+EST EY+ QR C+ ++GG +DSKGYGV TP GS + +A+
Sbjct: 713 ARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAV 772
Query: 798 LQLQEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLAAGLVLSVFVA 853
L+L E G L +K KWW G C +D+ + SAL + N+ G+F +L GL L++ VA
Sbjct: 773 LKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVA 832
Query: 854 IGEFIYKSR 862
+ EF YKSR
Sbjct: 833 LIEFCYKSR 841
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 375 bits (964), Expect = e-104
Identities = 273/896 (30%), Positives = 438/896 (48%), Gaps = 90/896 (10%)
Query: 17 TSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTT 76
T W LL ++C + A ++ IG IFE E ++ F+ AV+ ++ N ++ +
Sbjct: 5 TLW-LLPWICQCVSVRADSIIHIGAIFE----ENAAKDDRVFQLAVSDLSLNDDILQSEK 59
Query: 77 LTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWK 136
+TY I+ I + F+A + ACD + G+ AL + +S +A+QS+ +A+ +PH+ + +
Sbjct: 60 ITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-R 118
Query: 137 HPSVDNKDLFYINLYPD---YAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRL 186
+P + ++N PD Y SR +L LV W+ + Y+ + L
Sbjct: 119 NPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGL 178
Query: 187 QELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFY--------VIFDCSHETAAE 238
Q + SR + + ++++ L K +E I S + A
Sbjct: 179 QSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHS 238
Query: 239 ILKQILFMGMMTEYYHYFFTTLDLFALD-LELYRYSGVNMTGFRLL----------NIDN 287
+ + + + ++ H+ F ++ + L+L + MT R + +N
Sbjct: 239 FINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNN 298
Query: 288 PHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQ----LTV 343
+SS++ P+ G L M+ +YD+V M+A A HR + ++
Sbjct: 299 HRISSLLCD-----------PQEGYLQ-MLQISNLYLYDSVLMLANAFHRKLEDRKWHSM 346
Query: 344 SSLQCHRH--KPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTE 401
+SL C R KPW G ++ IK+ GLTG + F R+D + + GT
Sbjct: 347 ASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEF------REDSSNPYVQFEILGTT 400
Query: 402 KAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVM 461
S+ K +K+ W+S GLN + + S L TL V T+LEEP+VM
Sbjct: 401 -----YSETFGKDMRKLATWDSEKGLNGSLQERPMGSR----LQGLTLKVVTVLEEPFVM 451
Query: 462 YRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELI 521
++ L R++G+ +D+L L+ LGF Y++ PDG+YG Q WNGM+ ELI
Sbjct: 452 V--AENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELI 509
Query: 522 DHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMY 581
RADLA++ +TIT RE V+DFSK +M + IL +KP +FS P +W
Sbjct: 510 SKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPE-EKISIFSLFAPFDFAVWAC 568
Query: 582 VLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL 641
+ A V ++FV+ R + P + TL ++ W GA +QQG E
Sbjct: 569 IAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASA-----TLHSAIWIVYGAFVQQGGES 623
Query: 642 MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVR 701
+++ RIV G WW FTLI+ SSYTANLAAFLTV RM++PI + DL+KQ ++ YG VR
Sbjct: 624 SVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVR 683
Query: 702 DGSTMTFFKK------SKISTYEKMWAFMSSR-QQTALVRNSDEGIQRVLTTDYALLMES 754
D + +F+ + ST+ ++W +S V + EGI++ +YA L +
Sbjct: 684 DSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDV 743
Query: 755 TSIEY--VTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK 812
+EY +T +C++T IG I SKGYG+ GSPYRD + IL+LQ+ G L ++K+K
Sbjct: 744 AVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQK 803
Query: 813 WWRGNG-CPEEDNKEASA----LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRK 863
WW G C + A A L + + G+F +LA GL+L+ VA E + S +
Sbjct: 804 WWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNR 859
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 362 bits (930), Expect = e-100
Identities = 257/873 (29%), Positives = 433/873 (49%), Gaps = 70/873 (8%)
Query: 33 APQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEA 92
A ++ IG IF+ E ++ F+ AV +N+N ++ +T+ + ++ + F+A
Sbjct: 23 ADSIIHIGAIFD----ESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQA 78
Query: 93 SRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPH--IQTRWKHPSVDNKDLFYINL 150
+ AC+ + G+ AL +S ++QS+ +A+ +PH IQ L N
Sbjct: 79 VQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNR 138
Query: 151 YPDYAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIR 203
DY R IL +V Y W+ + Y+ + +QE + S+ + + ++
Sbjct: 139 NDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQ 198
Query: 204 QLPSG-NKDAKPL-----LKEMKKGKEFY--VIFDCSHETAAEILKQILFMGMMTEYYHY 255
++ + NK L ++E+ + ++ I + TA + +++ ++ H+
Sbjct: 199 KVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHW 258
Query: 256 FFTTLDLFALDL-ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
++ +D+ EL R S +T R ++S + + P+
Sbjct: 259 IIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQ 318
Query: 315 GMMTTEAALMYDAVYMVAIASHRASQ----LTVSSLQCHRH--KPWRLGPRFMNLIKEAR 368
M + + YD V ++A A H+ + +++SL C R KPW+ G + IK+
Sbjct: 319 NMEISNLYI-YDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGG 377
Query: 369 WDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLN 428
GLTG + F + NG + +I+ G E G +K+G WN +GLN
Sbjct: 378 VSGLTGELEFGE-NGGNPNVHFEILGTNY-GEELGRGV---------RKLGCWNPVTGLN 426
Query: 429 MTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSN 488
+ ++K +N+ + L V T+LEEP+VM S+ L +++G+ +D+L LSN
Sbjct: 427 GSLTDKKLENNMRGVV----LRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSN 480
Query: 489 ILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPF 548
LGF Y++ + PD KYG+ + G WNG+V EL+ RAD+ ++ LTIT RE V+DF+ +
Sbjct: 481 YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540
Query: 549 MTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH 608
M + +L R+ T +F+ L P +W + L V +++++ W NP
Sbjct: 541 MDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNPP 593
Query: 609 PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 668
S + TL NS WF G+ +QQG E+ L+TR++ G WW F LI+ISSYTA
Sbjct: 594 RLQMGS---MTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTA 650
Query: 669 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKI------STYEKMWA 722
NLAAFLT+ R+ES I S DL+KQT+I YG V D + + + S Y +MW
Sbjct: 651 NLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWR 710
Query: 723 FMS-SRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYV--TQRNCNLTQIGGLIDSKGY 779
++ S V S GIQ+V +YA + ++ +EYV +C+ IG + +GY
Sbjct: 711 MINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGY 770
Query: 780 GVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEDNKEASALGVEN 834
G+ GSPYRD + IL+LQ+ G + ++K KWW NG + ++ AL +++
Sbjct: 771 GIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKS 830
Query: 835 IGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDI 867
G+F +LAAG+VLS F+A+ E + RK + +
Sbjct: 831 FAGVFCILAAGIVLSCFIAMLETWWNKRKGSRV 863
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 260 bits (664), Expect = 5e-69
Identities = 242/939 (25%), Positives = 421/939 (44%), Gaps = 135/939 (14%)
Query: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
Query: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
Query: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
Query: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Y + ++ L RY+ + G +L+N N
Sbjct: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Query: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSN 424
+++ DG+TG + FN+ +G RK + I++L+ + H+ +KI IW
Sbjct: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKI-IWPGG 384
Query: 425 SGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG----- 471
++ K + ++ L + TI +EP+V + K + + G
Sbjct: 385 ------ETEKPRGYQMSTRLK-----IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKK 433
Query: 472 ------NDRFEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----N 508
ND G +C+DLL +L+ + F Y+V LV DGK+G Q +
Sbjct: 434 VICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNS 493
Query: 509 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPG 566
+K EWNGM+ EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T
Sbjct: 494 NKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST--- 550
Query: 567 VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNS 626
+ SF+ P +W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++
Sbjct: 551 LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSA 606
Query: 627 FWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685
WF G L+ G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I
Sbjct: 607 MWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITG 666
Query: 686 ADDLAKQT---KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQ 741
+D + K Y V+ S +F++ ++ST M+ M ++ E IQ
Sbjct: 667 INDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQ 719
Query: 742 RVLTTD-YALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 800
V +A + +S +E+ + C+L G L G+G+G SP++ ++++IL+
Sbjct: 720 AVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKS 779
Query: 801 QEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYK 860
E G + + + W R C N A+ L EN+ G+F+++A G+V +F+ E YK
Sbjct: 780 HENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK 838
Query: 861 SRKNNDIEQAFCFFYGL-----QCKQTHPTNSTSGTTLS 894
K+ +Q F + +Q HPT+ T LS
Sbjct: 839 RHKDARRKQMQLAFAAVNVWRKNLQQYHPTDITGPLNLS 877
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 255 bits (651), Expect = 2e-67
Identities = 233/904 (25%), Positives = 408/904 (45%), Gaps = 130/904 (14%)
Query: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
Query: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
Query: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
Query: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Y + ++ L RY+ + G +L+N N
Sbjct: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Query: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSN 424
+++ DG+TG + FN+ +G RK + I++L+ + H+ +KI IW
Sbjct: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKI-IWPGG 384
Query: 425 SGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG----- 471
++ K + ++ L + TI +EP+V + K + + G
Sbjct: 385 ------ETEKPRGYQMSTRLK-----IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKK 433
Query: 472 ------NDRFEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----N 508
ND G +C+DLL +L+ + F Y+V LV DGK+G Q +
Sbjct: 434 VICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNS 493
Query: 509 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPG 566
+K EWNGM+ EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T
Sbjct: 494 NKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST--- 550
Query: 567 VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNS 626
+ SF+ P +W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++
Sbjct: 551 LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSA 606
Query: 627 FWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685
WF G L+ G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I
Sbjct: 607 MWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITG 666
Query: 686 ADDLAKQT---KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQ 741
+D + K Y V+ S +F++ ++ST M+ M ++ E IQ
Sbjct: 667 INDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQ 719
Query: 742 RVLTTD-YALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 800
V +A + +S +E+ + C+L G L G+G+G SP++ ++++IL+
Sbjct: 720 AVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKS 779
Query: 801 QEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYK 860
E G + + + W R C N A+ L EN+ G+F+++A G+V +F+ E YK
Sbjct: 780 HENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK 838
Query: 861 SRKN 864
K+
Sbjct: 839 RHKD 842
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 255 bits (651), Expect = 2e-67
Identities = 233/904 (25%), Positives = 408/904 (45%), Gaps = 130/904 (14%)
Query: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
Query: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
Query: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
Query: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Y + ++ L RY+ + G +L+N N
Sbjct: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Query: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSN 424
+++ DG+TG + FN+ +G RK + I++L+ + H+ +KI IW
Sbjct: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKI-IWPGG 384
Query: 425 SGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG----- 471
++ K + ++ L + TI +EP+V + K + + G
Sbjct: 385 ------ETEKPRGYQMSTRLK-----IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKK 433
Query: 472 ------NDRFEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----N 508
ND G +C+DLL +L+ + F Y+V LV DGK+G Q +
Sbjct: 434 VICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNS 493
Query: 509 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPG 566
+K EWNGM+ EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T
Sbjct: 494 NKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST--- 550
Query: 567 VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNS 626
+ SF+ P +W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++
Sbjct: 551 LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSA 606
Query: 627 FWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685
WF G L+ G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I
Sbjct: 607 MWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITG 666
Query: 686 ADDLAKQT---KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQ 741
+D + K Y V+ S +F++ ++ST M+ M ++ E IQ
Sbjct: 667 INDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQ 719
Query: 742 RVLTTD-YALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 800
V +A + +S +E+ + C+L G L G+G+G SP++ ++++IL+
Sbjct: 720 AVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKS 779
Query: 801 QEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYK 860
E G + + + W R C N A+ L EN+ G+F+++A G+V +F+ E YK
Sbjct: 780 HENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK 838
Query: 861 SRKN 864
K+
Sbjct: 839 RHKD 842
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 190 bits (482), Expect = 6e-48
Identities = 140/485 (28%), Positives = 240/485 (49%), Gaps = 55/485 (11%)
Query: 415 WKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD-------- 466
W+++G W S L M + T+ + L + T+ E P+V+ D
Sbjct: 373 WERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMR 431
Query: 467 -----------------KPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 509
+P Y +G+C+D+LK++S + F YD+ LV +GK+G + +
Sbjct: 432 NTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKIN 491
Query: 510 KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVF 568
G WNGM+ E++ RA +AV LTI R +V+DFS PF+ GIS++ + NGT +P
Sbjct: 492 -GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS-- 548
Query: 569 SFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPHPCNPDS-DVVENNFTLLNS 626
+FL P S D+W+ + + L VS V +FV F+P + + C D + +FT+ +
Sbjct: 549 AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGGPSFTIGKA 605
Query: 627 FWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685
W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E +
Sbjct: 606 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSG 665
Query: 686 ADDLAKQ------TKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEG 739
D Q +G V +GST +++ + Y +M A+M Q R D+
Sbjct: 666 LSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMGKFNQ----RGVDDA 717
Query: 740 IQRVLTTDY-ALLMESTSIEYVTQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKIT 794
+ + T A + ++ + Y+ R+ C L IG + S GYG+ S ++ ++
Sbjct: 718 LLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVD 777
Query: 795 IAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAI 854
+AILQL +G++ ++ W G E++ +S L ++N+ G+F +L A + LS+ I
Sbjct: 778 LAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFI 837
Query: 855 GEFIY 859
E ++
Sbjct: 838 CEHLF 842
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 184 bits (467), Expect = 3e-46
Identities = 184/703 (26%), Positives = 313/703 (44%), Gaps = 115/703 (16%)
Query: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
Query: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
Query: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
+ Y+ + Q+ + H P+ + WDG
Sbjct: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDG------------ 345
Query: 384 LRKDFDLDIISLKEEGTEKAAGEVSKHLYK--VWKKIGIWNSNSGLNMTDSNKDKSSNIT 441
KD +S EEG + V L K W+K+G W +++ L++ + + + +
Sbjct: 346 --KD-----LSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFS 397
Query: 442 DSLANRT-LIVTTILEEPYVMYRKSDKPL----------------YGNDRFEG------- 477
D + L + T+ E P+V+ D PL N EG
Sbjct: 398 DCEPDDNHLSIVTLEEAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCC 456
Query: 478 --YCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 535
+C+D+LK+LS + F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 536 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-L 593
R +V+DFS PF+ GIS++ + NGT +P +FL P S +W+ + + L VS + +
Sbjct: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAV 573
Query: 594 FVIARFTPYEWYNPH------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKAL 646
FV F+P YN + P P +FT+ + W G + + PK
Sbjct: 574 FVFEYFSPVG-YNRNLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
Query: 647 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAV 700
+++I+ +W FF +I ++SYTANLAAF+ E + D Q +Y G V
Sbjct: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
Query: 701 RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYV 760
+GST + + ++ M F + ALV + A + ++ + Y
Sbjct: 686 PNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYK 738
Query: 761 TQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG 816
R+ C L IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G
Sbjct: 739 AGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTG 798
Query: 817 NGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859
E++ +S L ++N+ G+F +LAA + LS+ I E ++
Sbjct: 799 ICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 184 bits (467), Expect = 3e-46
Identities = 184/703 (26%), Positives = 313/703 (44%), Gaps = 115/703 (16%)
Query: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
Query: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
Query: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
+ Y+ + Q+ + H P+ + WDG
Sbjct: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDG------------ 345
Query: 384 LRKDFDLDIISLKEEGTEKAAGEVSKHLYK--VWKKIGIWNSNSGLNMTDSNKDKSSNIT 441
KD +S EEG + V L K W+K+G W +++ L++ + + + +
Sbjct: 346 --KD-----LSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFS 397
Query: 442 DSLANRT-LIVTTILEEPYVMYRKSDKPL----------------YGNDRFEG------- 477
D + L + T+ E P+V+ D PL N EG
Sbjct: 398 DCEPDDNHLSIVTLEEAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCC 456
Query: 478 --YCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 535
+C+D+LK+LS + F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 536 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-L 593
R +V+DFS PF+ GIS++ + NGT +P +FL P S +W+ + + L VS + +
Sbjct: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAV 573
Query: 594 FVIARFTPYEWYNPH------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKAL 646
FV F+P YN + P P +FT+ + W G + + PK
Sbjct: 574 FVFEYFSPVG-YNRNLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
Query: 647 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAV 700
+++I+ +W FF +I ++SYTANLAAF+ E + D Q +Y G V
Sbjct: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
Query: 701 RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYV 760
+GST + + ++ M F + ALV + A + ++ + Y
Sbjct: 686 PNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYK 738
Query: 761 TQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG 816
R+ C L IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G
Sbjct: 739 AGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTG 798
Query: 817 NGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859
E++ +S L ++N+ G+F +LAA + LS+ I E ++
Sbjct: 799 ICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 184 bits (467), Expect = 3e-46
Identities = 184/703 (26%), Positives = 313/703 (44%), Gaps = 115/703 (16%)
Query: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
Query: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
Query: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
+ Y+ + Q+ + H P+ + WDG
Sbjct: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDG------------ 345
Query: 384 LRKDFDLDIISLKEEGTEKAAGEVSKHLYK--VWKKIGIWNSNSGLNMTDSNKDKSSNIT 441
KD +S EEG + V L K W+K+G W +++ L++ + + + +
Sbjct: 346 --KD-----LSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFS 397
Query: 442 DSLANRT-LIVTTILEEPYVMYRKSDKPL----------------YGNDRFEG------- 477
D + L + T+ E P+V+ D PL N EG
Sbjct: 398 DCEPDDNHLSIVTLEEAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCC 456
Query: 478 --YCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 535
+C+D+LK+LS + F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 536 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-L 593
R +V+DFS PF+ GIS++ + NGT +P +FL P S +W+ + + L VS + +
Sbjct: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAV 573
Query: 594 FVIARFTPYEWYNPH------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKAL 646
FV F+P YN + P P +FT+ + W G + + PK
Sbjct: 574 FVFEYFSPVG-YNRNLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
Query: 647 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAV 700
+++I+ +W FF +I ++SYTANLAAF+ E + D Q +Y G V
Sbjct: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
Query: 701 RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYV 760
+GST + + ++ M F + ALV + A + ++ + Y
Sbjct: 686 PNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYK 738
Query: 761 TQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG 816
R+ C L IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G
Sbjct: 739 AGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTG 798
Query: 817 NGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859
E++ +S L ++N+ G+F +LAA + LS+ I E ++
Sbjct: 799 ICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 179 bits (453), Expect = 1e-44
Identities = 122/401 (30%), Positives = 209/401 (52%), Gaps = 35/401 (8%)
Query: 476 EGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 535
+G+C+D+LK L++ +GF YD+ LV +GK+G + D G WNGM+ E+ RAD+A+ LTI
Sbjct: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID-GVWNGMIGEVFYQRADMAIGSLTIN 543
Query: 536 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCVLF 594
R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ + + CL V V
Sbjct: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTV 601
Query: 595 VIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM--PKALSTRIVG 652
I + YN + FT+ S W + AL+ S + P+ +++I+
Sbjct: 602 FIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPVENPRGTTSKIMV 659
Query: 653 GIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGAVRDGSTM 706
+W FF +I ++SYTANLAAF+ E + D Q +++G V +GST
Sbjct: 660 LVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGST- 718
Query: 707 TFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY-----ALLMESTSIEYVT 761
+K+ S Y M ++M VR + ++ LT A + ++ + Y+
Sbjct: 719 ---EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMA 767
Query: 762 QRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN 817
+++ C L IG + + GYG+ GS ++ I +A+LQ + ++ M++ W G
Sbjct: 768 RKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGI 827
Query: 818 GCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 858
++ +S L ++N+ G+F +L + LS+ V E +
Sbjct: 828 CHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 174 bits (442), Expect = 3e-43
Identities = 133/494 (26%), Positives = 243/494 (49%), Gaps = 70/494 (14%)
Query: 407 VSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD 466
++ + +++W+ +G W S+++ + +R L V T+ E P+V+ D
Sbjct: 361 IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD 420
Query: 467 KPLYG------------NDRF-------------EGYCLDLLKELSNILGFIYDVKLVPD 501
G N F +G+C+D+LK+L+ ++ F YD+ LV +
Sbjct: 421 PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN 480
Query: 502 GKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 561
GK+G + +G WNGM+ E+ RAD+A+ LTI R +++DFS PF+ GIS++ + N
Sbjct: 481 GKHG-KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
Query: 562 GT-NPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENN 620
GT +P +FL P SP +W+ + + CL V + + +E+++P N + + +
Sbjct: 540 GTVSPS--AFLEPYSPAVWVMMFVMCLTVVAITVFM-----FEYFSPVSYNQNLTRGKKS 592
Query: 621 ----FTLLNSFWFGVGALMQQGSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAAFL 674
FT+ S W + AL+ S + P+ +++I+ +W FF +I ++SYTANLAAF+
Sbjct: 593 GGPAFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFM 651
Query: 675 TVERMESPIDSADDLAKQTK------IEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQ 728
E+ + D Q +G V +GST +++ S Y M
Sbjct: 652 IQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGST----ERNIRSNYRDM-------- 699
Query: 729 QTALVRNSDEGIQRVLTTDY-----ALLMESTSIEYVTQRN--CNLTQIGG--LIDSKGY 779
T +V+ + ++ LT+ A + ++ + Y+ ++ C L IG + + GY
Sbjct: 700 HTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGY 759
Query: 780 GVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIF 839
G+ S ++ I +A+LQ +G+ ++ W G E++ +S L ++N+ G+F
Sbjct: 760 GIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVF 819
Query: 840 --IVLAAGLVLSVF 851
+++A GL L VF
Sbjct: 820 YMLLVAMGLALLVF 833
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 162 bits (410), Expect = 1e-39
Identities = 160/661 (24%), Positives = 282/661 (42%), Gaps = 91/661 (13%)
Query: 259 TLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSII-EKWSMERLQAPPRPETGLLDGMM 317
T+ +F D+E R T F ++ P + ++ + ++E L+ P GL+
Sbjct: 324 TVVMFGCDMESIRRIFEITTQFGVMP---PELRWVLGDSQNVEELRTEGLP-LGLIAHGK 379
Query: 318 TTEAALMY---DAVYMVAIASHRASQ------LTVSSLQCHRHKPWRL--GPRFMNLIKE 366
TT++ + DA+ +VA A A+ L S++ C + L G +
Sbjct: 380 TTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLAN 439
Query: 367 ARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNS- 425
+ GL+G I + + + + I +L+ + K +W ++G W
Sbjct: 440 TTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKP----------MWTRLGSWQGGKI 489
Query: 426 ----GLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDK-------------- 467
G+ + + K+ S + L V T++E P+V R+ D
Sbjct: 490 VMDYGIWPEQAQRHKTHFQHPSKLH--LRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM 547
Query: 468 ---------------------PLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGA 506
P+ GYC+DLL++++ + F +D+ +V DGKYGA
Sbjct: 548 TNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGA 607
Query: 507 QNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPG 566
+ G W G+V +L+ A +AV +I R +VIDF+ PF + + IL R + P
Sbjct: 608 WKN-GHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP- 665
Query: 567 VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARF-TPYEWYNPHPCNPDSDVVENNFTLLN 625
+ +F+ PL +W LG+ L + A F T YEW +P P F+ +
Sbjct: 666 IGAFMWPLHWTMW-------LGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSS 718
Query: 626 SFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPID 684
+ L + + PK + R + +W F + +S+YTANLAA + E++ +
Sbjct: 719 ALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELS 778
Query: 685 SADDLA---KQTKIEYGAVRDGSTMTFFKKS--KISTYEKMWAFMSSRQQTALVRNSDEG 739
D +G VR+ S + ++S ++ Y + + ++ ++N E
Sbjct: 779 GIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEK 838
Query: 740 IQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQ 799
+ + D ALL SI+ +C L +G +GYG+G P SP I+ I Q
Sbjct: 839 LDAFI-MDKALLDYEVSID----ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQ 893
Query: 800 LQEEGKLHMMKEKWWRGNGCPEED--NKEASALGVENIGGIFIVLAAGLVLSVFVAIGEF 857
+ G + M+ +KW+R C + E +G+++ G+F++L G LS+ IGE
Sbjct: 894 YKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEH 953
Query: 858 I 858
I
Sbjct: 954 I 954
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 153 bits (387), Expect = 6e-37
Identities = 110/396 (27%), Positives = 189/396 (47%), Gaps = 31/396 (7%)
Query: 477 GYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITY 536
GYC+DLL+ L+ F +++ LV DGKYGA D G W G+V +L+ RA +AV +I
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD-GRWTGLVGDLLAGRAHMAVTSFSINS 536
Query: 537 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 596
R +V+DF+ PF + + I+ R + +P + +F+ PL W LGV L +
Sbjct: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHLT 588
Query: 597 ARF-TPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGI 654
A F T YEW +P+ P F+ ++ L ++ S PK + R++ +
Sbjct: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNL 648
Query: 655 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVRDGSTMTFFKK 711
W F L+++SSYTANLAA + ++ + D + +G V + S + KK
Sbjct: 649 WAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKK 708
Query: 712 SKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD----YALLMESTSIEYVT--QRNC 765
S + M A M R +LT+D A +M+ + ++Y +C
Sbjct: 709 S----FPDMHAHMRRHSAPTTPRG-----VAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
Query: 766 NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE--D 823
L +G +GYG+G P SP ++ I + + G + ++ +KW++ C +
Sbjct: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
Query: 824 NKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859
E + + + G+F++L GL ++ ++GE +
Sbjct: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
precursor [Homo sapiens]
Length = 433
Score = 136 bits (342), Expect = 1e-31
Identities = 110/431 (25%), Positives = 191/431 (44%), Gaps = 40/431 (9%)
Query: 34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEAS 93
P ++IGG+F ++ LA TS N + L + I +SF +
Sbjct: 24 PSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF---NLVPHVDNIETANSFAVT 80
Query: 94 RRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPD 153
C Q + GV A+FG SV + S C+AL + I + + + F + L P
Sbjct: 81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP---TEGESQFVLQLRP- 136
Query: 154 YAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA- 212
++ A+L L+ +Y W +Y+ G LQ +++ + + + + N +
Sbjct: 137 --SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSY 194
Query: 213 KPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRY 272
+ LL+E+ + +E + DC E IL+QI+ +G + YHY L + LE + +
Sbjct: 195 RQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIH 254
Query: 273 SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVA 332
G N+TGF+L++ + P V ++++W + P ET +AL YD V ++A
Sbjct: 255 GGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSET-----PPKYTSALTYDGVLVMA 309
Query: 333 --IASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL 384
S R ++ +S + PW G +K+ R GLTG++ F+ G
Sbjct: 310 ETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDH-YGR 368
Query: 385 RKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSL 444
R ++ +D+ LK G +K+G WN L + + N T ++
Sbjct: 369 RVNYTMDVFELKSTGP---------------RKVGYWNDMDKLVLI-QDVPTLGNDTAAI 412
Query: 445 ANRTLIVTTIL 455
NRT++VTTI+
Sbjct: 413 ENRTVVVTTIM 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,300,298
Number of Sequences: 37866
Number of extensions: 1441111
Number of successful extensions: 4227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3995
Number of HSP's gapped (non-prelim): 75
length of query: 918
length of database: 18,247,518
effective HSP length: 111
effective length of query: 807
effective length of database: 14,044,392
effective search space: 11333824344
effective search space used: 11333824344
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.