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Search of human proteins with 4503951
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503951 glucokinase isoform 1 [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503951 glucokinase isoform 1 [Homo sapiens] 931 0.0
gi|15967161 glucokinase isoform 3 [Homo sapiens] 903 0.0
gi|15967159 glucokinase isoform 2 [Homo sapiens] 902 0.0
gi|15553127 hexokinase 2 [Homo sapiens] 520 e-148
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens] 504 e-143
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens] 504 e-143
gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 504 e-143
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 504 e-143
gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens] 504 e-143
gi|156151420 hexokinase domain containing 1 [Homo sapiens] 495 e-140
gi|194097330 hexokinase 3 [Homo sapiens] 475 e-134
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 34 0.25
gi|219881540 hypothetical protein LOC199870 isoform 4 [Homo sapi... 32 1.2
gi|219881538 hypothetical protein LOC199870 isoform 2 [Homo sapi... 32 1.2
gi|219881536 hypothetical protein LOC199870 isoform 1 [Homo sapi... 32 1.2
gi|221139693 hypothetical protein LOC199870 isoform 5 [Homo sapi... 32 1.2
gi|22749341 hypothetical protein LOC199870 isoform 3 [Homo sapiens] 32 1.2
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 32 1.2
gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens] 32 1.6
gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens] 31 2.7
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 30 3.6
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 30 3.6
gi|194018732 hypothetical protein LOC100130958 [Homo sapiens] 30 3.6
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 30 3.6
gi|73623035 sperm associated antigen 5 [Homo sapiens] 30 4.7
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 30 4.7
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 30 4.7
gi|65287717 eukaryotic translation initiation factor 2 alpha kin... 30 4.7
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 30 6.1
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 30 6.1
>gi|4503951 glucokinase isoform 1 [Homo sapiens]
Length = 465
Score = 931 bits (2405), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
Sbjct: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60
Query: 61 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE 120
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
Sbjct: 61 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE 120
Query: 121 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN 180
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
Sbjct: 121 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN 180
Query: 181 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN 240
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
Sbjct: 181 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN 240
Query: 241 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE 300
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
Sbjct: 241 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE 300
Query: 301 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS 360
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
Sbjct: 301 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS 360
Query: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
Sbjct: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420
Query: 421 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Sbjct: 421 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465
>gi|15967161 glucokinase isoform 3 [Homo sapiens]
Length = 464
Score = 903 bits (2333), Expect = 0.0
Identities = 450/451 (99%), Positives = 451/451 (100%)
Query: 15 KVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 74
+VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF
Sbjct: 14 QVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 73
Query: 75 LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL 134
LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL
Sbjct: 74 LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL 133
Query: 135 DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 194
DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD
Sbjct: 134 DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 193
Query: 195 FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN 254
FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN
Sbjct: 194 FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN 253
Query: 255 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL 314
TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL
Sbjct: 254 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL 313
Query: 315 LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV 374
LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV
Sbjct: 314 LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV 373
Query: 375 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC 434
STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC
Sbjct: 374 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC 433
Query: 435 EITFIESEEGSGRGAALVSAVACKKACMLGQ 465
EITFIESEEGSGRGAALVSAVACKKACMLGQ
Sbjct: 434 EITFIESEEGSGRGAALVSAVACKKACMLGQ 464
>gi|15967159 glucokinase isoform 2 [Homo sapiens]
Length = 466
Score = 902 bits (2332), Expect = 0.0
Identities = 450/450 (100%), Positives = 450/450 (100%)
Query: 16 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75
VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL
Sbjct: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
Query: 76 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 135
SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD
Sbjct: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
Query: 136 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 195
KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
Query: 196 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 255
EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
Query: 256 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 315
EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
Query: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375
FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
Query: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 435
TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
Query: 436 ITFIESEEGSGRGAALVSAVACKKACMLGQ 465
ITFIESEEGSGRGAALVSAVACKKACMLGQ
Sbjct: 437 ITFIESEEGSGRGAALVSAVACKKACMLGQ 466
>gi|15553127 hexokinase 2 [Homo sapiens]
Length = 917
Score = 520 bits (1340), Expect = e-148
Identities = 242/447 (54%), Positives = 340/447 (76%), Gaps = 2/447 (0%)
Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73
+KV+Q L +L +E L ++ +R +KEM++GL TH A+VKMLPT+VRSTP+G+E G+
Sbjct: 20 QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 79
Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133
FL+LDLGGTNFRV+ VKV + G V+ ++Q+Y+IPED M G+ LFD+I+EC+++F
Sbjct: 80 FLALDLGGTNFRVLWVKVTDN--GLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANF 137
Query: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193
+DK Q+K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI+RRG
Sbjct: 138 MDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 197
Query: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253
DF++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+
Sbjct: 198 DFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCI 257
Query: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313
N EWGAFGD G L++ E+D+ +D S NPG+QL+EK+I G YMGELVRL+L+++ E
Sbjct: 258 NMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEE 317
Query: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373
LLF G+ S +L G FET+ +S +E + ++ +L LGL P+ DC R C+
Sbjct: 318 LLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQI 377
Query: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433
VSTR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P
Sbjct: 378 VSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG 437
Query: 434 CEITFIESEEGSGRGAALVSAVACKKA 460
C++ F+ SE+GSG+GAA+V+AVA + A
Sbjct: 438 CDVRFLRSEDGSGKGAAMVTAVAYRLA 464
Score = 516 bits (1329), Expect = e-146
Identities = 250/442 (56%), Positives = 334/442 (75%), Gaps = 2/442 (0%)
Query: 17 EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLS 76
++ L QL + L +V RRM+ EM+RGL ETH A VKMLPTYV +TP+G+E GDFL+
Sbjct: 471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA 530
Query: 77 LDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK 136
LDLGGTNFRV+LV+V G+ G V+ +++Y+IP++ M GT + LFD+I +CI+DFL+
Sbjct: 531 LDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEY 588
Query: 137 HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE 196
MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI RR +F+
Sbjct: 589 MGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFD 648
Query: 197 MDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTE 256
+DVVA+VNDTV TM++C +ED CEVG+IVGTG NACYMEEM+NVELVEG+EGRMCVN E
Sbjct: 649 LDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNME 708
Query: 257 WGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLF 316
WGAFGD+G LD+F E+D VDE S NPG+Q +EK+I G Y+GE+VR +L+ LLF
Sbjct: 709 WGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLF 768
Query: 317 HGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVST 376
G SE+L+TRG FET+F+SQ+ESD Q+ IL LGL + D IV+ C V+
Sbjct: 769 RGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVAR 828
Query: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEI 436
RAA +C AG+A V++R+RE+R D +++TVGVDG++YKLHP F + H +V+ L P C++
Sbjct: 829 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 888
Query: 437 TFIESEEGSGRGAALVSAVACK 458
+F++SE+GSG+GAAL++AVAC+
Sbjct: 889 SFLQSEDGSGKGAALITAVACR 910
>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
Length = 905
Score = 504 bits (1298), Expect = e-143
Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)
Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+
Sbjct: 452 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 511
Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
E GDFL+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I C
Sbjct: 512 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 569
Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI
Sbjct: 570 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 629
Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 630 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 689
Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 690 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 749
Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
+ LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+
Sbjct: 750 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 809
Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+
Sbjct: 810 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 869
Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458
L+P C ++F+ SE+GSG+GAAL++AV +
Sbjct: 870 LSPKCNVSFLLSEDGSGKGAALITAVGVR 898
Score = 474 bits (1219), Expect = e-134
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 16 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 10 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69
Query: 76 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 135
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 70 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 127
Query: 136 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 195
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 128 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 187
Query: 196 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 255
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 188 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 247
Query: 256 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 315
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 248 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 307
Query: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 308 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 367
Query: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 435
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 368 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 427
Query: 436 ITFIESEEGSGRGAALVSAVACKKA 460
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 428 VRFLLSESGSGKGAAMVTAVAYRLA 452
>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
Length = 917
Score = 504 bits (1298), Expect = e-143
Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)
Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+
Sbjct: 464 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 523
Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
E GDFL+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I C
Sbjct: 524 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 581
Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI
Sbjct: 582 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 641
Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 701
Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761
Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
+ LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+
Sbjct: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821
Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+
Sbjct: 822 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881
Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458
L+P C ++F+ SE+GSG+GAAL++AV +
Sbjct: 882 LSPKCNVSFLLSEDGSGKGAALITAVGVR 910
Score = 476 bits (1225), Expect = e-134
Identities = 223/447 (49%), Positives = 322/447 (72%), Gaps = 2/447 (0%)
Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73
+K+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GD
Sbjct: 20 KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 79
Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133
F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF
Sbjct: 80 FIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 137
Query: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193
++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RG
Sbjct: 138 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 197
Query: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253
D++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+
Sbjct: 198 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257
Query: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313
NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E
Sbjct: 258 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 317
Query: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373
LLF G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C
Sbjct: 318 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377
Query: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433
VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P
Sbjct: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 437
Query: 434 CEITFIESEEGSGRGAALVSAVACKKA 460
++ F+ SE GSG+GAA+V+AVA + A
Sbjct: 438 SDVRFLLSESGSGKGAAMVTAVAYRLA 464
>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 504 bits (1298), Expect = e-143
Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)
Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+
Sbjct: 468 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 527
Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
E GDFL+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I C
Sbjct: 528 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 585
Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI
Sbjct: 586 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 645
Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 646 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 705
Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 706 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 765
Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
+ LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+
Sbjct: 766 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 825
Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+
Sbjct: 826 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 885
Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458
L+P C ++F+ SE+GSG+GAAL++AV +
Sbjct: 886 LSPKCNVSFLLSEDGSGKGAALITAVGVR 914
Score = 476 bits (1225), Expect = e-134
Identities = 222/457 (48%), Positives = 326/457 (71%), Gaps = 2/457 (0%)
Query: 4 DRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVR 63
++ ++ + ++++ L +L +E L +M R +KEM GL + + A+VKMLPT+VR
Sbjct: 14 EKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVR 73
Query: 64 STPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLF 123
S P+GSE GDF++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LF
Sbjct: 74 SIPDGSEKGDFIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLF 131
Query: 124 DYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVG 183
D+++EC+ DF++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV
Sbjct: 132 DHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVK 191
Query: 184 LLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVEL 243
LL AIK+RGD++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++L
Sbjct: 192 LLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDL 251
Query: 244 VEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVR 303
VEGDEGRMC+NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVR
Sbjct: 252 VEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVR 311
Query: 304 LVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTD 363
L+L+++ E LLF G + +L TRG F T VS +E + IL+ LG+ PS D
Sbjct: 312 LILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDD 371
Query: 364 CDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERF 423
C V+ C VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RF
Sbjct: 372 CVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRF 431
Query: 424 HASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA 460
H ++RRL P ++ F+ SE GSG+GAA+V+AVA + A
Sbjct: 432 HKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLA 468
>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 504 bits (1298), Expect = e-143
Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)
Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+
Sbjct: 468 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 527
Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
E GDFL+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I C
Sbjct: 528 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 585
Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI
Sbjct: 586 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 645
Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 646 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 705
Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 706 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 765
Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
+ LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+
Sbjct: 766 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 825
Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+
Sbjct: 826 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 885
Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458
L+P C ++F+ SE+GSG+GAAL++AV +
Sbjct: 886 LSPKCNVSFLLSEDGSGKGAALITAVGVR 914
Score = 476 bits (1225), Expect = e-134
Identities = 222/457 (48%), Positives = 326/457 (71%), Gaps = 2/457 (0%)
Query: 4 DRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVR 63
++ ++ + ++++ L +L +E L +M R +KEM GL + + A+VKMLPT+VR
Sbjct: 14 EKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVR 73
Query: 64 STPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLF 123
S P+GSE GDF++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LF
Sbjct: 74 SIPDGSEKGDFIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLF 131
Query: 124 DYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVG 183
D+++EC+ DF++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV
Sbjct: 132 DHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVK 191
Query: 184 LLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVEL 243
LL AIK+RGD++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++L
Sbjct: 192 LLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDL 251
Query: 244 VEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVR 303
VEGDEGRMC+NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVR
Sbjct: 252 VEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVR 311
Query: 304 LVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTD 363
L+L+++ E LLF G + +L TRG F T VS +E + IL+ LG+ PS D
Sbjct: 312 LILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDD 371
Query: 364 CDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERF 423
C V+ C VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RF
Sbjct: 372 CVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRF 431
Query: 424 HASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA 460
H ++RRL P ++ F+ SE GSG+GAA+V+AVA + A
Sbjct: 432 HKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLA 468
>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
Length = 916
Score = 504 bits (1298), Expect = e-143
Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)
Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+
Sbjct: 463 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 522
Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
E GDFL+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I C
Sbjct: 523 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 580
Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI
Sbjct: 581 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 640
Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 641 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 700
Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 701 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 760
Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
+ LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+
Sbjct: 761 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 820
Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+
Sbjct: 821 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 880
Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458
L+P C ++F+ SE+GSG+GAAL++AV +
Sbjct: 881 LSPKCNVSFLLSEDGSGKGAALITAVGVR 909
Score = 474 bits (1219), Expect = e-134
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 16 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 21 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
Query: 76 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 135
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 81 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 138
Query: 136 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 195
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 139 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 198
Query: 196 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 255
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 199 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 258
Query: 256 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 315
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 259 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 318
Query: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 319 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 378
Query: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 435
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 379 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 438
Query: 436 ITFIESEEGSGRGAALVSAVACKKA 460
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 439 VRFLLSESGSGKGAAMVTAVAYRLA 463
>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
Length = 917
Score = 495 bits (1274), Expect = e-140
Identities = 236/446 (52%), Positives = 327/446 (73%), Gaps = 3/446 (0%)
Query: 11 AKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE 70
A++++++++LA FQL E L V +M+ E++ GL+ ++H A+V+MLPTYV P+G+E
Sbjct: 465 AQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTE 524
Query: 71 VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECI 130
G FL+LDLGGTNFRV+LVK+ G SV+ +++++IP + M GT E LFD+I +CI
Sbjct: 525 KGKFLALDLGGTNFRVLLVKIRSGRR---SVRMYNKIFAIPLEIMQGTGEELFDHIVQCI 581
Query: 131 SDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIK 190
+DFLD +K LPLGFTFSFP R IDKG L+ WTKGFKA+ EG +VV +LR+AIK
Sbjct: 582 ADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIK 641
Query: 191 RRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR 250
RR +F++D+VA+VNDTV TM++C YED CE+G+I GTG N CYME+M+N+E+VEG EG+
Sbjct: 642 RRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGK 701
Query: 251 MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLV 310
MC+NTEWG FGD+G +D+ YD VDE S NPG+Q YEK+ G Y+GE+VR +L+ L
Sbjct: 702 MCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLT 761
Query: 311 DENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRA 370
+ LLF G+ SE+LRTRG FET+F+SQ+ESD Q+ IL LGL + D +V+
Sbjct: 762 KQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEV 821
Query: 371 CESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL 430
C +VS RAA +C AGLA ++ + RE + + +RITVGVDG++YKLHP F +V+ L
Sbjct: 822 CGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKEL 881
Query: 431 TPSCEITFIESEEGSGRGAALVSAVA 456
P C++TF+ SE+GSG+GAAL++AVA
Sbjct: 882 APRCDVTFMLSEDGSGKGAALITAVA 907
Score = 472 bits (1214), Expect = e-133
Identities = 222/453 (49%), Positives = 323/453 (71%), Gaps = 2/453 (0%)
Query: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65
++++ + +KV++ L +L ++ L +MRR + EM++GL +T+ A+VKMLPT+VR+
Sbjct: 12 SKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAI 71
Query: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 125
P+GSE G+FLSLDLGG+ FRV+ V+V E EG+ V+ + Q Y P + + G LF+Y
Sbjct: 72 PDGSENGEFLSLDLGGSKFRVLKVQVAE--EGKRHVQMESQFYPTPNEIIRGNGTELFEY 129
Query: 126 ISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL 185
+++C++DF+ +KHKKLPLG TFSFP R +++G+LL+WTK FKA G + +VV L
Sbjct: 130 VADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRL 189
Query: 186 RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVE 245
A++R D ++D++A+VNDTV TM++C Y+D CEVG+I+GTG NACYME+M N++LVE
Sbjct: 190 TKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVE 249
Query: 246 GDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLV 305
GDEGRMC+NTEWGAFGD G L++ E+DR +D S NPG+QL+EK+I G Y+GELVRL+
Sbjct: 250 GDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLI 309
Query: 306 LLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCD 365
LL++ LLF GE S L T+G ETR V+ +E IL LGL PS DC
Sbjct: 310 LLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCI 369
Query: 366 IVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHA 425
V+ C VS R+A++C+A LA ++ R+RE++ + +R TVG+DG++YK+HP + +R H
Sbjct: 370 AVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHK 429
Query: 426 SVRRLTPSCEITFIESEEGSGRGAALVSAVACK 458
VR+L PSC++ F+ SE GS +GAA+V+AVA +
Sbjct: 430 VVRKLVPSCDVRFLLSESGSTKGAAMVTAVASR 462
>gi|194097330 hexokinase 3 [Homo sapiens]
Length = 923
Score = 475 bits (1223), Expect = e-134
Identities = 237/451 (52%), Positives = 324/451 (71%), Gaps = 9/451 (1%)
Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
AA + +E+ LA F+L + L V +M+K M +GLR E +S++MLPT+VR+TP+GS
Sbjct: 477 AAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGS 533
Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
E GDFL+LDLGGTNFRV+LV+V G V+ ++YSIPE G+ + LFD+I +C
Sbjct: 534 ERGDFLALDLGGTNFRVLLVRVTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDC 587
Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
I DF K + + LPLGFTFSFP R +D+GILLNWTKGFKAS EG +VV LLR+AI
Sbjct: 588 IVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAI 647
Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
RR E++VVA+VNDTV TM+SC YED +CE+G+IVGTG NACYMEE++NV V GD G
Sbjct: 648 TRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSG 707
Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
RMC+N EWGAFGD G L +D VD++S NPG+Q +EK+I G Y+GE+VR +LL L
Sbjct: 708 RMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHL 767
Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
+LF G+ ++L+TR F+T+F+S++ESD+ +Q+ IL LGL ++ D +V
Sbjct: 768 TSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLE 827
Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
C++VS RAA +C AG+A V+ ++RE+R + + ++VGVDG++YKLHP F A+VR
Sbjct: 828 VCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRE 887
Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACKKA 460
L P C +TF++SE+GSG+GAALV+AVAC+ A
Sbjct: 888 LAPRCVVTFLQSEDGSGKGAALVTAVACRLA 918
Score = 374 bits (961), Expect = e-104
Identities = 189/449 (42%), Positives = 284/449 (63%), Gaps = 4/449 (0%)
Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73
E V++ L +F++ L+++ + M++ LR + +V+MLPTYV STP G+E GD
Sbjct: 31 ELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGD 90
Query: 74 FLSLDLG--GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECIS 131
F+ L+LG G + RV+ V + G EG V+ + Q + IP++ M G + LFD+ + C+S
Sbjct: 91 FVVLELGATGASLRVLWVTL-TGIEGH-RVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLS 148
Query: 132 DFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKR 191
+FLD + + L LGF+FSFP +D+ L++WTKGF+ SG EG +VV LLRDAI+R
Sbjct: 149 EFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRR 208
Query: 192 RGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM 251
+G + +DVVA+VNDTV TM+ C CEVG++V TG NACYMEE ++V +++ D GR+
Sbjct: 209 QGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRV 268
Query: 252 CVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVD 311
CV+ EWG+F D G L L +D +D S NPG Q +EK+IGG Y+GELVRLVL L
Sbjct: 269 CVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLAR 328
Query: 312 ENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRAC 371
+LF G S L ++G+ V+++E + +++ IL LGL P +D ++V+ C
Sbjct: 329 CGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVC 388
Query: 372 ESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLT 431
+V TRAA +C+A LA V++ ++ SR + +++ V G V + HP F +V L
Sbjct: 389 AAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLA 448
Query: 432 PSCEITFIESEEGSGRGAALVSAVACKKA 460
P C+++ I S +G GRG A+V+AVA + A
Sbjct: 449 PECDVSLIPSVDGGGRGVAMVTAVAARLA 477
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 34.3 bits (77), Expect = 0.25
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 4 DRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEE 52
+RA++++ + + E++LA + ++E+L + + +Q+E D GL L E+
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
>gi|219881540 hypothetical protein LOC199870 isoform 4 [Homo
sapiens]
Length = 278
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/57 (28%), Positives = 32/57 (56%), Gaps = 9/57 (15%)
Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKM 57
ML + +M K++K+ ++ A+FQ QE ++ M +M+K TH+E + ++
Sbjct: 202 MLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEK---------THKEVTEQL 249
>gi|219881538 hypothetical protein LOC199870 isoform 2 [Homo
sapiens]
Length = 312
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/57 (28%), Positives = 32/57 (56%), Gaps = 9/57 (15%)
Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKM 57
ML + +M K++K+ ++ A+FQ QE ++ M +M+K TH+E + ++
Sbjct: 236 MLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEK---------THKEVTEQL 283
>gi|219881536 hypothetical protein LOC199870 isoform 1 [Homo
sapiens]
Length = 341
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/57 (28%), Positives = 32/57 (56%), Gaps = 9/57 (15%)
Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKM 57
ML + +M K++K+ ++ A+FQ QE ++ M +M+K TH+E + ++
Sbjct: 265 MLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEK---------THKEVTEQL 312
>gi|221139693 hypothetical protein LOC199870 isoform 5 [Homo
sapiens]
Length = 227
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/57 (28%), Positives = 32/57 (56%), Gaps = 9/57 (15%)
Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKM 57
ML + +M K++K+ ++ A+FQ QE ++ M +M+K TH+E + ++
Sbjct: 151 MLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEK---------THKEVTEQL 198
>gi|22749341 hypothetical protein LOC199870 isoform 3 [Homo sapiens]
Length = 307
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/57 (28%), Positives = 32/57 (56%), Gaps = 9/57 (15%)
Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKM 57
ML + +M K++K+ ++ A+FQ QE ++ M +M+K TH+E + ++
Sbjct: 231 MLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEK---------THKEVTEQL 278
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/54 (29%), Positives = 30/54 (55%)
Query: 2 LDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASV 55
L D R + ++++Q L E DL+K++RR+ K+ D +R E+ + S+
Sbjct: 721 LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSI 774
>gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens]
Length = 1079
Score = 31.6 bits (70), Expect = 1.6
Identities = 15/57 (26%), Positives = 31/57 (54%)
Query: 2 LDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKML 58
L +R ME EK+ + + Q +++D+ + MQ+ + + ++ T EA +K+L
Sbjct: 252 LQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVL 308
>gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens]
Length = 529
Score = 30.8 bits (68), Expect = 2.7
Identities = 15/46 (32%), Positives = 27/46 (58%)
Query: 11 AKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVK 56
+KK K+EQ+ E ++ E+ KK +++ E + ++ EE SVK
Sbjct: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK 485
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 30.4 bits (67), Expect = 3.6
Identities = 14/52 (26%), Positives = 33/52 (63%), Gaps = 1/52 (1%)
Query: 9 EAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60
E K+K+E++ + Q + KK+++ +QK ++R L+++T ++ + + L T
Sbjct: 810 EPLNKDKIEELKKNREEQVQKKKKILKELQK-VERQLQMKTQQQFTKEYLET 860
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 30.4 bits (67), Expect = 3.6
Identities = 14/52 (26%), Positives = 33/52 (63%), Gaps = 1/52 (1%)
Query: 9 EAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60
E K+K+E++ + Q + KK+++ +QK ++R L+++T ++ + + L T
Sbjct: 810 EPLNKDKIEELKKNREEQVQKKKKILKELQK-VERQLQMKTQQQFTKEYLET 860
>gi|194018732 hypothetical protein LOC100130958 [Homo sapiens]
Length = 242
Score = 30.4 bits (67), Expect = 3.6
Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 3/70 (4%)
Query: 1 MLDDR-ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQK--EMDRGLRLETHEEASVKM 57
ML+ R AR A + EQ+L+E +L L++V RR+ E++ + + +A +++
Sbjct: 142 MLEQRLAREIRALERSKEQLLSERRLVRAKLREVERRLHSPPEVEGAMAVNDGLKAELEI 201
Query: 58 LPTYVRSTPE 67
VRS PE
Sbjct: 202 FGEQVRSAPE 211
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 30.4 bits (67), Expect = 3.6
Identities = 15/40 (37%), Positives = 28/40 (70%), Gaps = 1/40 (2%)
Query: 3 DDRARMEAAKKEKVEQILAEF-QLQEEDLKKVMRRMQKEM 41
++R+ + ++++ EQ+L QLQEEDLK + RR Q+++
Sbjct: 270 EERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKL 309
>gi|73623035 sperm associated antigen 5 [Homo sapiens]
Length = 1193
Score = 30.0 bits (66), Expect = 4.7
Identities = 17/64 (26%), Positives = 34/64 (53%)
Query: 13 KEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVG 72
K + E+++ +FQ L++ +RR KE+++ + H ++ +P VR E +
Sbjct: 1130 KNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLL 1189
Query: 73 DFLS 76
+FLS
Sbjct: 1190 EFLS 1193
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 30.0 bits (66), Expect = 4.7
Identities = 17/60 (28%), Positives = 38/60 (63%), Gaps = 8/60 (13%)
Query: 2 LDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKE----MDR--GLRLETHEEASV 55
+ D +++ ++E Q + + +++ EDLK+ +R++Q+E +D+ GL+L+ +EE V
Sbjct: 267 MQDEVNVKSHQRE--HQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 324
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 30.0 bits (66), Expect = 4.7
Identities = 17/60 (28%), Positives = 38/60 (63%), Gaps = 8/60 (13%)
Query: 2 LDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKE----MDR--GLRLETHEEASV 55
+ D +++ ++E Q + + +++ EDLK+ +R++Q+E +D+ GL+L+ +EE V
Sbjct: 280 MQDEVNVKSHQRE--HQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 337
>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase
4 [Homo sapiens]
Length = 1649
Score = 30.0 bits (66), Expect = 4.7
Identities = 23/56 (41%), Positives = 35/56 (62%), Gaps = 10/56 (17%)
Query: 1 MLDDRAR------MEAAKKEKVEQ--ILAEFQLQEEDLKKVMRRMQKEMDRGLRLE 48
ML+ RA+ +EA +KE+ EQ IL E Q ++E++K+ +R KEM + RLE
Sbjct: 149 MLERRAQEEQQRLLEAKRKEEQEQREILHEIQRRKEEIKEEKKR--KEMAKQERLE 202
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 29.6 bits (65), Expect = 6.1
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 4/36 (11%)
Query: 417 PSFKERFHASVRRLTPSCEIT----FIESEEGSGRG 448
PS E ++RR TPSCE T +E EGSG G
Sbjct: 2200 PSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAG 2235
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 29.6 bits (65), Expect = 6.1
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 4/36 (11%)
Query: 417 PSFKERFHASVRRLTPSCEIT----FIESEEGSGRG 448
PS E ++RR TPSCE T +E EGSG G
Sbjct: 2206 PSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAG 2241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,606,394
Number of Sequences: 37866
Number of extensions: 723978
Number of successful extensions: 2318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 2261
Number of HSP's gapped (non-prelim): 54
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.