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Search of human proteins with 4503911
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503911 growth associated protein 43 isoform 2 [Homo
sapiens]
(238 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens] 468 e-132
gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens] 446 e-126
gi|30795231 brain abundant, membrane attached signal protein 1 [... 66 2e-11
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 66 3e-11
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 66 3e-11
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 66 3e-11
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 66 3e-11
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 64 9e-11
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 64 9e-11
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 64 1e-10
gi|153070260 myristoylated alanine-rich protein kinase C substra... 62 6e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 61 7e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 61 7e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 60 2e-09
gi|24415404 MDN1, midasin homolog [Homo sapiens] 58 8e-09
gi|157738619 smoothelin-like 1 [Homo sapiens] 56 2e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 55 5e-08
gi|55956788 nucleolin [Homo sapiens] 54 2e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 53 2e-07
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 53 2e-07
gi|42518068 trans-golgi network protein 2 [Homo sapiens] 53 3e-07
gi|117938759 GNAS complex locus XLas [Homo sapiens] 52 3e-07
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 52 6e-07
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 52 6e-07
gi|104526627 triadin [Homo sapiens] 52 6e-07
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 50 2e-06
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 50 2e-06
gi|7662162 ALEX2 protein [Homo sapiens] 49 4e-06
gi|29540562 ALEX2 protein [Homo sapiens] 49 4e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 49 4e-06
>gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens]
Length = 238
Score = 468 bits (1203), Expect = e-132
Identities = 238/238 (100%), Positives = 238/238 (100%)
Query: 1 MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ 60
MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ
Sbjct: 1 MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ 60
Query: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT 120
AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT
Sbjct: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT 120
Query: 121 EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT 180
EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT
Sbjct: 121 EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT 180
Query: 181 TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
Sbjct: 181 TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
>gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens]
Length = 274
Score = 446 bits (1147), Expect = e-126
Identities = 228/229 (99%), Positives = 229/229 (100%)
Query: 10 QVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 69
+VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK
Sbjct: 46 RVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 105
Query: 70 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA
Sbjct: 106 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165
Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189
SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA
Sbjct: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 225
Query: 190 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
Sbjct: 226 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
>gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
Length = 227
Score = 66.2 bits (160), Expect = 2e-11
Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%)
Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108
KK KG +D +A E + + A +G K+ E AE A A K ++P + E
Sbjct: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 168
+EEK+GE DAA A +AP + EK A A + A E PK A
Sbjct: 66 AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 224
+ AA +AA PAA + +K +P ++ A + ++ ++KP S
Sbjct: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
Query: 225 EGKE 228
KE
Sbjct: 182 SSKE 185
Score = 60.8 bits (146), Expect = 1e-09
Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%)
Query: 13 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72
K DQ E + E + AA K +A K + EK + A+AE K E
Sbjct: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106
Query: 73 P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
A G GE AEAA PA + P AGE PS+E EG+ + AP APA
Sbjct: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTE-APAAPA 158
Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189
+ E K+ A + S++ +PSSK + PAA T A ++TP A+ AA
Sbjct: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204
Query: 190 KATAQPPTE 198
A P E
Sbjct: 205 SAEEPKPVE 213
Score = 56.2 bits (134), Expect = 2e-08
Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 35/222 (15%)
Query: 14 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAP 73
N +D+K ++ + KA AAT+ + + + E + A AEA + E P
Sbjct: 13 NVNDEKAKEK----DKKAEGAATEEEGTPK----------ESEPQAAAEPAEAKEGKEKP 58
Query: 74 VAD----GVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
D EK+GE A A ++P++ A E +E K EQAAP PA
Sbjct: 59 DQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA---PEQEQAAP-GPA 114
Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA---------AAAT 180
+ E +AE +A S +P++ E + + EPK+ + PAA A A+ +
Sbjct: 115 AGGEAPKAAEAAAAPAESA--APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
Query: 181 TPAAEDAAAKATAQPPTETGESS--QAEENIEAVDETKPKES 220
P + +AA + P SS +A+ + +E KP E+
Sbjct: 173 KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEA 214
Score = 43.1 bits (100), Expect = 2e-04
Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 11/147 (7%)
Query: 103 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT----KASTDNSPSSKAED 158
K G ++EK E D E AA + + +E A E A K D KAE+
Sbjct: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
Query: 159 -------APAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA 211
A AKEE +A+ AA A + + A P GE+ +A E A
Sbjct: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAA 128
Query: 212 VDETKPKESARQDEGKEEEPEADQEHA 238
E+ + + +E EP+ + A
Sbjct: 129 PAESAAPAAGEEPSKEEGEPKKTEAPA 155
Score = 37.0 bits (84), Expect = 0.015
Identities = 30/84 (35%), Positives = 41/84 (48%), Gaps = 13/84 (15%)
Query: 68 KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 127
KK EAP A ++ T ++ APA+ SK PG + PS + E AATE AP +
Sbjct: 149 KKTEAPAAPAAQE-----TKSDGAPASDSK---PGSSEAAPSSK---ETPAATE--APSS 195
Query: 128 PASSEEKAGSAETESATKASTDNS 151
++ A SAE +A NS
Sbjct: 196 TPKAQGPAASAEEPKPVEAPAANS 219
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 65.9 bits (159), Expect = 3e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 220 SARQ 223
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.8 bits (112), Expect = 9e-06
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%)
Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134
Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
G TPS + + A E + A S+ T T A NS +S
Sbjct: 1135 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1182
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1183 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1231
Query: 215 TKPKESARQDEG 226
T P++S + +G
Sbjct: 1232 TTPQKSRKPKKG 1243
Score = 47.0 bits (110), Expect = 1e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 44.3 bits (103), Expect = 9e-05
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 216 KPKESARQDEGKEEEPE 232
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 43.1 bits (100), Expect = 2e-04
Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)
Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
++ + D+ +E + +KP KA +TK + + K+ G+ V+
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
K+ + P + E EG+ + E APA G++ KA E + + A
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
PA + A A K D+ SS+ E+ PA + QA + AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
+ PA E A PP +TG A +A + +S+ ++ EEE A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 42.4 bits (98), Expect = 4e-04
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)
Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
A TPA AA+ KA A T SS++E+ N+
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023
Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235
+ P KES+R +GK++E A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Score = 41.6 bits (96), Expect = 6e-04
Identities = 55/256 (21%), Positives = 94/256 (36%), Gaps = 34/256 (13%)
Query: 12 EKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKKDDV 59
E++D +++ E +KP K H+ + + G + K+DD
Sbjct: 873 EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932
Query: 60 QAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGETPS 109
++ E++ EAP A + A PA P KA + S
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 110 EEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
+ ++ E P ++ +A A KAS + SSK +
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 162 -KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETKPKE 219
K+E V +AV AT+P + AK T + + E QA + E+ D++ ++
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS--ED 1110
Query: 220 SARQDEGKEEEPEADQ 235
S+ G EE+ E Q
Sbjct: 1111 SSDSSSGSEEDGEGPQ 1126
Score = 37.7 bits (86), Expect = 0.009
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 31.2 bits (69), Expect = 0.82
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Score = 30.4 bits (67), Expect = 1.4
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1187 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1243
Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
G+ A Q+ +S K + E K D + S +
Sbjct: 1244 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1303
Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
+++ D PAA T + A E A + + + T + + +
Sbjct: 1304 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1363
Query: 215 TKPKESARQDEGKEEEPEAD 234
K + + +G ++EPE +
Sbjct: 1364 EKKGKGSLGSQGAKDEPEEE 1383
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 65.9 bits (159), Expect = 3e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 220 SARQ 223
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1114 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1172
Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
G P ET EE A E + A S+ T T A NS +S
Sbjct: 1173 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1219
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1220 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1268
Query: 215 TKPKESARQDEG 226
T P++S + +G
Sbjct: 1269 TTPQKSRKPKKG 1280
Score = 47.0 bits (110), Expect = 1e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 44.3 bits (103), Expect = 9e-05
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 216 KPKESARQDEGKEEEPE 232
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 43.1 bits (100), Expect = 2e-04
Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)
Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
++ + D+ +E + +KP KA +TK + + K+ G+ V+
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
K+ + P + E EG+ + E APA G++ KA E + + A
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
PA + A A K D+ SS+ E+ PA + QA + AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
+ PA E A PP +TG A +A + +S+ ++ EEE A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 42.4 bits (98), Expect = 4e-04
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)
Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
A TPA AA+ KA A T SS++E+ N+
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023
Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235
+ P KES+R +GK++E A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Score = 37.7 bits (86), Expect = 0.009
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 32.7 bits (73), Expect = 0.28
Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%)
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
++ K+ + ++DG +++G T ++ PA+ P + + A A
Sbjct: 1041 SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1088
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
A ++ +G A++ S S +A+ +PK +V A T A ++ +E
Sbjct: 1089 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1147
Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
D++ ++ E GE Q ++ + T + +E E E D
Sbjct: 1148 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1194
Score = 31.2 bits (69), Expect = 0.82
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Score = 30.4 bits (67), Expect = 1.4
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1224 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1280
Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
G+ A Q+ +S K + E K D + S +
Sbjct: 1281 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1340
Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
+++ D PAA T + A E A + + + T + + +
Sbjct: 1341 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1400
Query: 215 TKPKESARQDEGKEEEPEAD 234
K + + +G ++EPE +
Sbjct: 1401 EKKGKGSLGSQGAKDEPEEE 1420
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 65.9 bits (159), Expect = 3e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 220 SARQ 223
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134
Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
G P ET EE A E + A S+ T T A NS +S
Sbjct: 1135 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1181
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1182 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1230
Query: 215 TKPKESARQDEG 226
T P++S + +G
Sbjct: 1231 TTPQKSRKPKKG 1242
Score = 47.0 bits (110), Expect = 1e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 44.3 bits (103), Expect = 9e-05
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 216 KPKESARQDEGKEEEPE 232
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 43.1 bits (100), Expect = 2e-04
Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)
Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
++ + D+ +E + +KP KA +TK + + K+ G+ V+
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
K+ + P + E EG+ + E APA G++ KA E + + A
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
PA + A A K D+ SS+ E+ PA + QA + AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
+ PA E A PP +TG A +A + +S+ ++ EEE A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 42.4 bits (98), Expect = 4e-04
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)
Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
A TPA AA+ KA A T SS++E+ N+
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023
Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235
+ P KES+R +GK++E A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Score = 41.6 bits (96), Expect = 6e-04
Identities = 55/256 (21%), Positives = 94/256 (36%), Gaps = 34/256 (13%)
Query: 12 EKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKKDDV 59
E++D +++ E +KP K H+ + + G + K+DD
Sbjct: 873 EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932
Query: 60 QAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGETPS 109
++ E++ EAP A + A PA P KA + S
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 110 EEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
+ ++ E P ++ +A A KAS + SSK +
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 162 -KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETKPKE 219
K+E V +AV AT+P + AK T + + E QA + E+ D++ ++
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS--ED 1110
Query: 220 SARQDEGKEEEPEADQ 235
S+ G EE+ E Q
Sbjct: 1111 SSDSSSGSEEDGEGPQ 1126
Score = 37.7 bits (86), Expect = 0.009
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 31.2 bits (69), Expect = 0.82
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Score = 30.4 bits (67), Expect = 1.4
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1186 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1242
Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
G+ A Q+ +S K + E K D + S +
Sbjct: 1243 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1302
Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
+++ D PAA T + A E A + + + T + + +
Sbjct: 1303 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1362
Query: 215 TKPKESARQDEGKEEEPEAD 234
K + + +G ++EPE +
Sbjct: 1363 EKKGKGSLGSQGAKDEPEEE 1382
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 65.9 bits (159), Expect = 3e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 220 SARQ 223
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.8 bits (112), Expect = 9e-06
Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 27/205 (13%)
Query: 47 TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------ 100
T ++K EK++D +++E E++ +EA + K T A+A PA P
Sbjct: 750 TVTQVKAEKQEDSESSEEESDS-EEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
Query: 101 PGKA--------GETPSEEKKGEGDAATEQAAPQAPAS--SEEKAGSAETESATKASTDN 150
PGK +PS+ K + + PAS S KA + ++ T D+
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 151 SPSSKAEDAPAKEEPKQADVPAAVT--AAAATTPAAEDAAAKATAQPPTETGESSQAEEN 208
S + D+ + E P+ T AA PA E A PP +TG S
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS------ 922
Query: 209 IEAVDETKPKESARQDEGKEEEPEA 233
A K +S E + + EA
Sbjct: 923 --AAQAGKQDDSGSSSEESDSDGEA 945
Score = 47.0 bits (110), Expect = 1e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 44.3 bits (103), Expect = 9e-05
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 216 KPKESARQDEGKEEEPE 232
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 43.1 bits (100), Expect = 2e-04
Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)
Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
++ + D+ +E + +KP KA +TK + + K+ G+ V+
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
K+ + P + E EG+ + E APA G++ KA E + + A
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
PA + A A K D+ SS+ E+ PA + QA + AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
+ PA E A PP +TG A +A + +S+ ++ EEE A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 37.7 bits (86), Expect = 0.009
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 36.6 bits (83), Expect = 0.020
Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 16/104 (15%)
Query: 56 KDDVQAAEAEANKKDEAPVADGVEKKGE------GTTTAEAAPATGSKPDEPGKAGETPS 109
++D ++E E++ ++EA V+ G+ A+ +P G+ P PGK G PS
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTG--PS 922
Query: 110 EEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPS 153
+ G+ D + +SSEE E +A ++ D S
Sbjct: 923 AAQAGKQD--------DSGSSSEESDSDGEAPAAVTSAQDQESS 958
Score = 35.8 bits (81), Expect = 0.033
Identities = 43/169 (25%), Positives = 70/169 (41%), Gaps = 20/169 (11%)
Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA 177
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA 952
Score = 31.2 bits (69), Expect = 0.82
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 64.3 bits (155), Expect = 9e-11
Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%)
Query: 59 VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 108
V A +A+++ +D + +D VE K + A+ P G+ P PGKAG
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
S+ K G+ + +E +SSEE + S E A KA S K A APAKE
Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
P++ PA T PA A A + + E S +EE EA + KP A Q
Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295
Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347
Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405
Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
E + A++ + K + + K
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430
Score = 47.8 bits (112), Expect = 9e-06
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%)
Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095
Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
G TPS + + A E + A S+ T T A NS +S
Sbjct: 1096 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1143
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1144 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1192
Query: 215 TKPKESARQDEG 226
T P++S + +G
Sbjct: 1193 TTPQKSRKPKKG 1204
Score = 47.0 bits (110), Expect = 1e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582
Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Score = 44.3 bits (103), Expect = 9e-05
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434
Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
KAG + + DNS SS+ A E + PAA+
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550
Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610
Query: 216 KPKESARQDEGKEEEPE 232
+P E + E + E E
Sbjct: 611 RPAEDSSSSEESDSEEE 627
Score = 42.4 bits (98), Expect = 4e-04
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)
Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 710 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 769
Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 770 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 827
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 828 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886
Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
A TPA AA+ KA A T SS++E+ N+
Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946
Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235
+ P KES+R +GK++E A Q
Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 984
Score = 41.6 bits (96), Expect = 6e-04
Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%)
Query: 72 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 131
A G+ G+ +++E ++ + D KA E + + A PA
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243
Query: 132 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 185
+ A A K D+ SS+ E+ PA + QA + AA+ PA E
Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
A PP +TG A +A + +S+ ++ EEE A
Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348
Score = 39.3 bits (90), Expect = 0.003
Identities = 52/228 (22%), Positives = 74/228 (32%), Gaps = 21/228 (9%)
Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKA-ATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
+ K+ +D E + E +A A AT AS + L K+ +A +
Sbjct: 72 QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
A K + + G T A + A T E + EG AA
Sbjct: 132 AGK-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
K G A +S D S SS D K K V AA+ PA
Sbjct: 187 --------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKG 232
Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
AT PP + G + ++ +E S + +EE P A
Sbjct: 233 TPGKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279
Score = 37.7 bits (86), Expect = 0.009
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579
Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635
Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
A + KA S AE + +++S + S S
Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755
Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
G +S + + +D G EE +E A
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804
Score = 31.6 bits (70), Expect = 0.63
Identities = 30/153 (19%), Positives = 62/153 (40%), Gaps = 20/153 (13%)
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPAT-----GSKPDEPGKAGETPSEEKKGEGDAAT 120
++ K+ + ++DG +++G T ++ PA+ + KA E + + +
Sbjct: 964 SSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGV 1023
Query: 121 EQAAPQAPASSEE-------------KAGSAETESATKA--STDNSPSSKAEDAPAKEEP 165
+ A PA+S + K E + ATKA S+D+S S + ++E+
Sbjct: 1024 DSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDG 1083
Query: 166 KQADVPAAVTAAAATTPAAEDAAAKATAQPPTE 198
+ + TP+ + + TA +E
Sbjct: 1084 EGPQGAKSAHTLVGPTPSRTETLVEETAAESSE 1116
Score = 30.4 bits (67), Expect = 1.4
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1148 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1204
Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
G+ A Q+ +S K + E K D + S +
Sbjct: 1205 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1264
Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
+++ D PAA T + A E A + + + T + + +
Sbjct: 1265 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1324
Query: 215 TKPKESARQDEGKEEEPEAD 234
K + + +G ++EPE +
Sbjct: 1325 EKKGKGSLGSQGAKDEPEEE 1344
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 64.3 bits (155), Expect = 9e-11
Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%)
Query: 59 VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 108
V A +A+++ +D + +D VE K + A+ P G+ P PGKAG
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
S+ K G+ + +E +SSEE + S E A KA S K A APAKE
Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
P++ PA T PA A A + + E S +EE EA + KP A Q
Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295
Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347
Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405
Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
E + A++ + K + + K
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095
Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
G P ET EE A E + A S+ T T A NS +S
Sbjct: 1096 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1142
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1143 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1191
Query: 215 TKPKESARQDEG 226
T P++S + +G
Sbjct: 1192 TTPQKSRKPKKG 1203
Score = 47.0 bits (110), Expect = 1e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582
Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Score = 44.3 bits (103), Expect = 9e-05
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434
Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
KAG + + DNS SS+ A E + PAA+
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550
Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610
Query: 216 KPKESARQDEGKEEEPE 232
+P E + E + E E
Sbjct: 611 RPAEDSSSSEESDSEEE 627
Score = 42.4 bits (98), Expect = 4e-04
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)
Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 710 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 769
Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 770 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 827
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 828 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886
Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
A TPA AA+ KA A T SS++E+ N+
Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946
Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235
+ P KES+R +GK++E A Q
Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 984
Score = 41.6 bits (96), Expect = 6e-04
Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%)
Query: 72 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 131
A G+ G+ +++E ++ + D KA E + + A PA
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243
Query: 132 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 185
+ A A K D+ SS+ E+ PA + QA + AA+ PA E
Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
A PP +TG A +A + +S+ ++ EEE A
Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348
Score = 39.3 bits (90), Expect = 0.003
Identities = 52/228 (22%), Positives = 74/228 (32%), Gaps = 21/228 (9%)
Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKA-ATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
+ K+ +D E + E +A A AT AS + L K+ +A +
Sbjct: 72 QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
A K + + G T A + A T E + EG AA
Sbjct: 132 AGK-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
K G A +S D S SS D K K V AA+ PA
Sbjct: 187 --------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKG 232
Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
AT PP + G + ++ +E S + +EE P A
Sbjct: 233 TPGKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279
Score = 37.7 bits (86), Expect = 0.009
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579
Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635
Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
A + KA S AE + +++S + S S
Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755
Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
G +S + + +D G EE +E A
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804
Score = 32.7 bits (73), Expect = 0.28
Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%)
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
++ K+ + ++DG +++G T ++ PA+ P + + A A
Sbjct: 964 SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1011
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
A ++ +G A++ S S +A+ +PK +V A T A ++ +E
Sbjct: 1012 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1070
Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
D++ ++ E GE Q ++ + T + +E E E D
Sbjct: 1071 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1117
Score = 30.4 bits (67), Expect = 1.4
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1147 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1203
Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
G+ A Q+ +S K + E K D + S +
Sbjct: 1204 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1263
Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
+++ D PAA T + A E A + + + T + + +
Sbjct: 1264 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1323
Query: 215 TKPKESARQDEGKEEEPEAD 234
K + + +G ++EPE +
Sbjct: 1324 EKKGKGSLGSQGAKDEPEEE 1343
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 63.5 bits (153), Expect = 1e-10
Identities = 65/244 (26%), Positives = 115/244 (47%), Gaps = 32/244 (13%)
Query: 10 QVEKNDDDQKIEQDGIKPEDKAH-KAATKIQASFRGHITRKKLKGE---KKDDVQAAEAE 65
++++ +++ + E DG++ + K+ + A +++ +K +G+ + D V+A EAE
Sbjct: 2008 EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE------TQKTEGDAQPESDGVEAPEAE 2061
Query: 66 ANKKDEAPVADGVEKKGEGTTTAE-----AAPATG-SKPDEPG-KAGETPSEEKKGEGDA 118
+EA A+G ++ EG E A A G ++P+ G +A E E +K EG
Sbjct: 2062 ----EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA--AVTA 176
A E P S +A AE E+ + S +A+DA + +P+ + A A
Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQPE-----SEGVEAQDAEGEAQPESEGIEAQEAEEE 2172
Query: 177 AAATTPAAEDAAAKATAQPPTETGESSQAE----ENIEAVDETKPKESARQDEGKEEEPE 232
A E A+ AQP +E E+ +AE +E V+ + +E A+ + E PE
Sbjct: 2173 AQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPE 2232
Query: 233 ADQE 236
A+ E
Sbjct: 2233 AEGE 2236
Score = 62.8 bits (151), Expect = 3e-10
Identities = 64/244 (26%), Positives = 102/244 (41%), Gaps = 42/244 (17%)
Query: 10 QVEKNDDDQKIEQDGIKP---EDKAHKAATKIQASFRGHITRKKLKGEKKD-DVQAAEAE 65
+ +K + D + E DG++ E++A +A ++Q + + E +D D Q AE E
Sbjct: 2040 ETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA------EGEAHPESEDVDAQEAEGE 2093
Query: 66 ANKKDE---APVADGVEKKGEGT----TTAEAAPATGS--KPDEPGKA------------ 104
A + E AP A+G +K EG T EA P + P+ G+A
Sbjct: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
Query: 105 -GETPSEEKKGEGDAATEQAAPQ-----APASSEEKAGSAETESATKASTDNSPSSKAED 158
GE E + E A E+A P+ AP + E +E A +A + P + +
Sbjct: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
Query: 159 AP-----AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVD 213
AP A+ EP+ + P A A + K + Q G+S +A E+ V
Sbjct: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273
Query: 214 ETKP 217
E +P
Sbjct: 2274 EDRP 2277
Score = 58.5 bits (140), Expect = 5e-09
Identities = 61/204 (29%), Positives = 95/204 (46%), Gaps = 28/204 (13%)
Query: 60 QAAEAEANKKDEAPVADGVEKKGE--GTTTAEAAPATG-SKPDEPG-KAGETPSEEKKGE 115
Q + E N + EA A G + G+ G EA A G ++P+ G +A E + ++ E
Sbjct: 1806 QGSGHEDNLQGEA-AAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE 1864
Query: 116 GDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE---EPKQADVPA 172
G+A E +AP + E +E +A + P S+ +AP E +P+ V A
Sbjct: 1865 GEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA 1924
Query: 173 AVT-------AAAATTPAAEDAA--AKATAQPPTETGESSQAE-------ENIEAVD--- 213
T + A AE+AA A+ QP +E ES +AE E++EA++
Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV 1984
Query: 214 ETKPKESARQDEGKE-EEPEADQE 236
ET+ E Q E ++ E PEA+ E
Sbjct: 1985 ETQEAEGEAQPESEDVEAPEAEGE 2008
Score = 57.4 bits (137), Expect = 1e-08
Identities = 54/195 (27%), Positives = 81/195 (41%), Gaps = 20/195 (10%)
Query: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE-------EKK 113
A EAE + E+ V + E + E +E A + + GE E E +
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006
Query: 114 GEGDAATEQAAPQA------PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 167
GE A E+A P++ P S E+A E E+ K D P S +AP EE Q
Sbjct: 2007 GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQ-KTEGDAQPESDGVEAPEAEEEAQ 2065
Query: 168 ADVPAAVTAAAATTPAAEDA---AAKATAQPPTETGESSQAE---ENIEAVDETKPKESA 221
A P +ED A+ AQP +E E+ +AE + E ++ + + A
Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125
Query: 222 RQDEGKEEEPEADQE 236
+ + E PEA+ E
Sbjct: 2126 QPESEGIEAPEAEGE 2140
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/196 (28%), Positives = 89/196 (45%), Gaps = 27/196 (13%)
Query: 54 EKKDDVQAAEAEANKKDE---APVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPS 109
E + D Q AE EA + E AP A+G + + E T EA +P+ G E P
Sbjct: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEV--QPESEG--AEAPE 1910
Query: 110 EEKKGEGDA----ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK---AEDAPAK 162
EK+ + + A E P S +A AE E+A +A P S+ +++A +
Sbjct: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAE-EAAQEAEGQTQPESEVIESQEAEEE 1969
Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
+P+ DV A E A+ AQP +E E+ +AE ++ +E E+
Sbjct: 1970 AQPESEDVEALEVEV-------ETQEAEGEAQPESEDVEAPEAEGEMQEAEE----EAQP 2018
Query: 223 QDEGKEEEPEADQEHA 238
+ +G E +P+++ E A
Sbjct: 2019 ESDGVEAQPKSEGEEA 2034
Score = 52.4 bits (124), Expect = 3e-07
Identities = 52/201 (25%), Positives = 86/201 (42%), Gaps = 21/201 (10%)
Query: 53 GEKKDDVQAAEAEANKKDEAPVADG----VEKKGEGTTTAEAAPATGSKPDE--PGKAG- 105
GE + D A E E + A E++GEG + GS ++ G+A
Sbjct: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAA 1820
Query: 106 ---ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-- 160
+ P + EG A E P S +A AE + A +A + P S+ +AP
Sbjct: 1821 GGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD-AQEAEGEAQPESEDVEAPEA 1879
Query: 161 ---AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVD 213
A+ E + + P A + AE A+ AQP TE+ E+ + E E +
Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE 1939
Query: 214 ETKPKESARQDEGKEEEPEAD 234
+ +E+A++ EG + +PE++
Sbjct: 1940 AQEAEEAAQEAEG-QTQPESE 1959
Score = 51.6 bits (122), Expect = 6e-07
Identities = 45/182 (24%), Positives = 84/182 (46%), Gaps = 8/182 (4%)
Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
+ + +A EAE + E + +E +GE +E A A ++ G+T E +
Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVI 1961
Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-AKEEPKQADVPAA 173
E A E+A P+ S + +A E E+ +A + P S+ +AP A+ E ++A+ A
Sbjct: 1962 ESQEAEEEAQPE---SEDVEALEVEVET-QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ 2017
Query: 174 VTA-AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232
+ P +E A+ +T +Q E + V+ + +E A++ EG+ +E E
Sbjct: 2018 PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES--DGVEAPEAEEEAQEAEGEVQEAE 2075
Query: 233 AD 234
+
Sbjct: 2076 GE 2077
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/201 (26%), Positives = 89/201 (44%), Gaps = 19/201 (9%)
Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
+ +DV+A EAE + E+ + E + E +E A A ++ + + + E +G
Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEG 1929
Query: 115 EGDAATEQA-APQAPASSEEKAGSAETESATKAS--TDNSPSSKAEDAPAKE---EPKQA 168
E + +E A A +A +++E G + ES S + ++ED A E E ++A
Sbjct: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEA 1989
Query: 169 DVPAAVTAAAATTPAAEDAAAKAT--AQPPTETGES---SQAEENIEAVDETKPKESARQ 223
+ A + P AE +A AQP ++ E+ S+ EE E ET+ E Q
Sbjct: 1990 EGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQ 2049
Query: 224 DEG--------KEEEPEADQE 236
E +EE EA+ E
Sbjct: 2050 PESDGVEAPEAEEEAQEAEGE 2070
Score = 33.9 bits (76), Expect = 0.13
Identities = 41/203 (20%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 10 QVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK- 68
Q+E+ ++ ++++G++ E+ +G+++++ Q E E
Sbjct: 1321 QLEETKTEEGLQEEGVQLEETKETEG----------------EGQQEEEAQLEEIEETGG 1364
Query: 69 ---KDEAPVADGVEKKGEGTTTAEAA---------PATGSKPDEPGKAGETPSEEKKGEG 116
++E + V++ EG EA P GS + +P + E
Sbjct: 1365 EGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQED 1424
Query: 117 DAATEQAAPQAPASSEE--KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
D E+ A +A AS+E G+ E ++ PS+ + ++ EP P A
Sbjct: 1425 DPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484
Query: 175 ------TAAAATTPAAEDAAAKA 191
T A T AAE +++ A
Sbjct: 1485 MMGQEHTQAQPTQGAAERSSSVA 1507
Score = 30.8 bits (68), Expect = 1.1
Identities = 25/120 (20%), Positives = 50/120 (41%), Gaps = 9/120 (7%)
Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
+G +A + G++ G GE P G G EQ P + E+ S+++ +
Sbjct: 478 DGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSA 537
Query: 143 ATKASTDNSP--------SSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 194
+T + +S KA +++E + PA+ A + ++ ++D A+ Q
Sbjct: 538 STGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPAS-PALSLSSLRSDDLQAETQGQ 596
Score = 29.6 bits (65), Expect = 2.4
Identities = 41/210 (19%), Positives = 74/210 (35%), Gaps = 21/210 (10%)
Query: 8 TKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQAS------FRGHITRKKLKGEKKDDVQA 61
TKQV + + ++ QDG P ++T+ QAS G + + L G V
Sbjct: 683 TKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTP 742
Query: 62 AEAEANKKDEAP-VADGVEKKGE-GTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119
A +P A G+ G+ T AP D K+G E+ +
Sbjct: 743 AVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQP 802
Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE-----------EPKQA 168
+ Q + G + ++ T P+ +A+ P+ E P+
Sbjct: 803 SSPLVLQVGRPEQGAVGPHRSHCCSQPGT--QPAQEAQRGPSPEASWLCGRYCPTPPRGR 860
Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTE 198
P +++ +T ++ + A+ P E
Sbjct: 861 PCPQRRSSSCGSTGSSHQSTARGPGGSPQE 890
Score = 29.3 bits (64), Expect = 3.1
Identities = 42/195 (21%), Positives = 66/195 (33%), Gaps = 22/195 (11%)
Query: 56 KDDVQAAEAEANKKDEAPVAD-GVEKKGEGT---TTAEAAPATGSKPDEPGKAGETPSEE 111
KD + E + KD P D G ++ G T ++A P GS + S
Sbjct: 1142 KDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGV 1201
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 171
G + +++ P + + + TE K S S E E +Q P
Sbjct: 1202 DISSGSGGSGESS--VPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFP 1259
Query: 172 AAVTAAAATTPAAEDAA----------------AKATAQPPTETGESSQAEENIEAVDET 215
+ A A ED A A+ T Q + E+ + E +E
Sbjct: 1260 TFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEA 1319
Query: 216 KPKESARQDEGKEEE 230
E + +EG +EE
Sbjct: 1320 VQLEETKTEEGLQEE 1334
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 61.6 bits (148), Expect = 6e-10
Identities = 49/196 (25%), Positives = 84/196 (42%), Gaps = 24/196 (12%)
Query: 30 KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD-------EAPVADGVEKKG 82
KA AT ++ +K+ +K + + NKK+ EAP A+G + +
Sbjct: 137 KAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEA 196
Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA--------PASSEEK 134
G A AA A + ++ GE + ++G ++A PQ PAS E K
Sbjct: 197 AGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETK 256
Query: 135 AGSAET--------ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED 186
A + E+ A+ +PS+ AP ++E A+ PAA A++A +++
Sbjct: 257 AAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEEPAAAAASSACAAPSQE 316
Query: 187 AAAKATAQ-PPTETGE 201
A + + + PP E E
Sbjct: 317 AQPECSPEAPPAEAAE 332
Score = 52.4 bits (124), Expect = 3e-07
Identities = 64/222 (28%), Positives = 87/222 (39%), Gaps = 61/222 (27%)
Query: 70 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
D +P A K E A A +P G +PS +KGE AA AAP+A A
Sbjct: 44 DASPAAAESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAA---AAPEAGA 100
Query: 130 SSEEKAG-------------SAETESATKASTDNSPSSKAED----APAKEEPK------ 166
S EK +AE E+A+ AS+ +SP KAED +P+ E PK
Sbjct: 101 SPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSP--KAEDGATPSPSNETPKKKKKRF 158
Query: 167 ------------------------QADVPAAV----TAAAATTPAAEDAAAKATAQPPTE 198
+A+ PAA AA AA +A A + Q
Sbjct: 159 SFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAP 218
Query: 199 TGESSQAEENIEAVD--ETKPKESARQDEGKEEEPEADQEHA 238
E++ EE D E KP+E+A E+ P +D+ A
Sbjct: 219 GEEAAAGEEGAAGGDPQEAKPQEAA---VAPEKPPASDETKA 257
Score = 46.6 bits (109), Expect = 2e-05
Identities = 66/253 (26%), Positives = 89/253 (35%), Gaps = 41/253 (16%)
Query: 22 QDGIKPEDKAH---KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK---KDEAPVA 75
+ G K E +A+ AA K + + G EK + AA EA + EAP
Sbjct: 51 ESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAE 110
Query: 76 DGVEKKGEGTTT----AEAAPATGSKPDE----PGKAGETPSEEKKG------------- 114
+ G T A AA +T S E P + ETP ++KK
Sbjct: 111 GEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFS 170
Query: 115 ------EGDAATEQAAPQAPASSEEKAGSAETESATK-ASTDNSPSSKAEDAPAKEEPKQ 167
E E AP A +E AG A +A A++ ++ E+A A EE
Sbjct: 171 FKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAA 230
Query: 168 ADVPA-AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE------NIEAVDETKPKES 220
P A AA P A+ + A E +AEE EA P
Sbjct: 231 GGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAP 290
Query: 221 ARQDEGKEEEPEA 233
Q+ EEP A
Sbjct: 291 PEQEAAPAEEPAA 303
Score = 45.1 bits (105), Expect = 6e-05
Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 27/151 (17%)
Query: 63 EAEANKKDEAPVADGVEK-----KGEGTTTAEAAPA---TGSKPDEPGKAGETPSEEKKG 114
EA A + EA VA K G +A+PA +G+K +E G P+ +K+
Sbjct: 13 EAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAK-EELQANGSAPAADKEE 71
Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEE------PKQA 168
A + A+P A E A +A A SP K +APA+ E P A
Sbjct: 72 PAAAGSGAASPSAAEKGEPAAAAAPEAGA-------SPVEK--EAPAEGEAAEPGSPTAA 122
Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTET 199
+ AA A++ ++P AED AT P ET
Sbjct: 123 EGEAASAASSTSSPKAEDG---ATPSPSNET 150
Score = 41.6 bits (96), Expect = 6e-04
Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 17/134 (12%)
Query: 81 KGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE----------QAAPQAPAS 130
KGE A P + P KA + K GDA+ QA APA+
Sbjct: 11 KGEA---AAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQANGSAPAA 67
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED---- 186
+E+ +A + +A+ ++ + + A A P + + PA AA +P A +
Sbjct: 68 DKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAA 127
Query: 187 AAAKATAQPPTETG 200
+AA +T+ P E G
Sbjct: 128 SAASSTSSPKAEDG 141
Score = 37.7 bits (86), Expect = 0.009
Identities = 42/139 (30%), Positives = 54/139 (38%), Gaps = 25/139 (17%)
Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAE----------DAPA--K 162
+G+AA E+ A ASS KA E K + D SP++ APA K
Sbjct: 11 KGEAAAERPGEAAVASSPSKANGQEN-GHVKVNGDASPAAAESGAKEELQANGSAPAADK 69
Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQP----------PTETGESSQAEENIEAV 212
EEP A AA +AA A AA +A A P E G + AE EA
Sbjct: 70 EEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEG--EAA 127
Query: 213 DETKPKESARQDEGKEEEP 231
S + ++G P
Sbjct: 128 SAASSTSSPKAEDGATPSP 146
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 61.2 bits (147), Expect = 7e-10
Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 28/234 (11%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
K VE+ ++ K+E + + E+ ++ S +K EKK+ A +
Sbjct: 451 KFVEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEE 494
Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQA 127
K+E P A+ E A+ +P + P+ + GE EE + E + E A + QA
Sbjct: 495 KEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 548
Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTP 182
EK GS+E E + + ++ E+A AKEE K + V A A
Sbjct: 549 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 608
Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
E A + P E G+S + +E ++ +S +++GK P++ E
Sbjct: 609 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 662
Score = 49.7 bits (117), Expect = 2e-06
Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%)
Query: 13 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72
K + + E+ +PE + + A K K+ +GEK+++ + E ++DE
Sbjct: 485 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 542
Query: 73 PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 117
+D G EK+G EG T AEA E +A E E+K E
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 595
Query: 118 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 177
A E+ A EKA S K+ + S +P +E+ K + VP +
Sbjct: 596 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 650
Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 235
+P + + P +++ +A+ + V+E K K + E KEEE + +
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710
Query: 236 E 236
E
Sbjct: 711 E 711
Score = 44.7 bits (104), Expect = 7e-05
Identities = 50/233 (21%), Positives = 87/233 (37%), Gaps = 37/233 (15%)
Query: 6 RRTKQVEKNDDDQKIEQDGI------KPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV 59
+ K+VE+ ++ +++ + KPE KA K +G K E+K
Sbjct: 583 KEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 641
Query: 60 QAAEAEANKKDEAPVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDA 118
++ +K ++PV VE+KG+ + P E S+ + G+G+
Sbjct: 642 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 701
Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178
E+ A EEK E K +D P K++
Sbjct: 702 KEEEEKEVKEAPKEEKVEKKE--------------EKPKDVPEKKK-------------- 733
Query: 179 ATTPAAEDAAAK-ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
A +P E+A A+ T + + +E + + + K KE A + G EEE
Sbjct: 734 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 786
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 61.2 bits (147), Expect = 7e-10
Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 28/234 (11%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
K VE+ ++ K+E + + E+ ++ S +K EKK+ A +
Sbjct: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEE 118
Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQA 127
K+E P A+ E A+ +P + P+ + GE EE + E + E A + QA
Sbjct: 119 KEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 172
Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTP 182
EK GS+E E + + ++ E+A AKEE K + V A A
Sbjct: 173 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 232
Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
E A + P E G+S + +E ++ +S +++GK P++ E
Sbjct: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 286
Score = 49.7 bits (117), Expect = 2e-06
Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%)
Query: 13 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72
K + + E+ +PE + + A K K+ +GEK+++ + E ++DE
Sbjct: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 166
Query: 73 PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 117
+D G EK+G EG T AEA E +A E E+K E
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 219
Query: 118 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 177
A E+ A EKA S K+ + S +P +E+ K + VP +
Sbjct: 220 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 274
Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 235
+P + + P +++ +A+ + V+E K K + E KEEE + +
Sbjct: 275 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 334
Query: 236 E 236
E
Sbjct: 335 E 335
Score = 44.7 bits (104), Expect = 7e-05
Identities = 50/233 (21%), Positives = 87/233 (37%), Gaps = 37/233 (15%)
Query: 6 RRTKQVEKNDDDQKIEQDGI------KPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV 59
+ K+VE+ ++ +++ + KPE KA K +G K E+K
Sbjct: 207 KEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 265
Query: 60 QAAEAEANKKDEAPVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDA 118
++ +K ++PV VE+KG+ + P E S+ + G+G+
Sbjct: 266 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 325
Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178
E+ A EEK E K +D P K++
Sbjct: 326 KEEEEKEVKEAPKEEKVEKKE--------------EKPKDVPEKKK-------------- 357
Query: 179 ATTPAAEDAAAK-ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
A +P E+A A+ T + + +E + + + K KE A + G EEE
Sbjct: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 410
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 59.7 bits (143), Expect = 2e-09
Identities = 53/224 (23%), Positives = 95/224 (42%), Gaps = 15/224 (6%)
Query: 22 QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKK 81
++ IK +K+ K ++ +++ E++ + + E + + E A+G E++
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEE 500
Query: 82 GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE 141
+ EAA + ++P+E K E E+A A S EKA S E
Sbjct: 501 TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE----KEEAKSPAEVKSPEKAKSPAKE 556
Query: 142 SATKASTDNSPSSKAEDAPAK-EEPKQADVPA---------AVTAAAATTPAAEDAAAKA 191
A SP + +PA+ + P++A PA A + A +P E+A + A
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616
Query: 192 TAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235
A+ P + S AE ++ KE A+ E K + PE ++
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE-KAKSPEKEE 659
Score = 56.6 bits (135), Expect = 2e-08
Identities = 57/225 (25%), Positives = 88/225 (39%), Gaps = 17/225 (7%)
Query: 25 IKPEDKA-HKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA-PVADGVEKKG 82
+K E K KA + ++ + K + K DV++ EA+ K+EA AD +K
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785
Query: 83 EGTTTAEA-APATGSKP-DEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAET 140
+ E +P P E KA E +K+ E+ PQ E + E
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845
Query: 141 ESATKASTDNSPSSKAEDAPAKEEPK----QADVPAAVTAAAATTPAAEDAAAKATAQPP 196
++ T+ SK E+AP KE PK + PA + A ++ A P
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905
Query: 197 TETGESSQAEENIEAVDETKPKESA-----RQDEGKEEEPEADQE 236
E +A +E ++ KPKE D+ K +EP E
Sbjct: 906 PE----KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Score = 55.5 bits (132), Expect = 4e-08
Identities = 56/240 (23%), Positives = 108/240 (45%), Gaps = 15/240 (6%)
Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEA 66
+ K EK +K E++ + E++ + + + K+ +G++++ + EAE
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 67 NKKDE----APVADGVEKKGEGTTTAEA-APATGSKPD--EPGKAGETPSEEKKGEGDAA 119
+++ A A EK+ + EA +PA P+ E E S EK
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556
Query: 120 TEQAAPQAPASSEEKAGS-AETESATKASTDNSPSSKAEDAPAK-EEPKQADVPA---AV 174
++ P+A + +E+A S AE +S KA SP+ + +PA+ + P++A P A
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAK---SPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 175 TAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
+ A A +P E+A + A + P + ++ E ++ KE A+ E + +A+
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Score = 55.5 bits (132), Expect = 4e-08
Identities = 61/257 (23%), Positives = 107/257 (41%), Gaps = 31/257 (12%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEAN 67
++ E +++ K E+ G + E + + TK + K+ K K++ ++ AEA++
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
Query: 68 KKDEA--PVADGVEKKGEGTTTAEA-APATGSKPDE-----------PGKAGETPSEEKK 113
+K+EA P +K + EA +P P++ P KA EE K
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593
Query: 114 GEGDAAT---------EQAAPQAPASS---EEKAGSAETESATKASTDNSPSSKAED--- 158
+A + E+A A A S EE AE +S KA + +K+ +
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653
Query: 159 APAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK 218
+P KEE K + + A A +P + KA A+ P + + E ++ K
Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK 713
Query: 219 ESARQDEGKEEEPEADQ 235
E A+ E K + P ++
Sbjct: 714 EEAKSPE-KAKSPVKEE 729
Score = 53.9 bits (128), Expect = 1e-07
Identities = 53/194 (27%), Positives = 86/194 (44%), Gaps = 16/194 (8%)
Query: 47 TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKP--DEPGKA 104
T K+K E+K V K ++ V VE++ E T E K +E GK
Sbjct: 434 THIKVKSEEKIKV------VEKSEKETVI--VEEQTEETQVTEEVTEEEEKEAKEEEGKE 485
Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-E 163
E EE+ G+ T+ + AS E++A S E A + SP + +PA+ +
Sbjct: 486 EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 164 EPKQADVPA---AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220
P++A PA A + A +P E+A + A + P + S A+E ++ E K E
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAKSPEK 603
Query: 221 ARQDEGKEEEPEAD 234
A+ +E + A+
Sbjct: 604 AKSPVKEEAKSPAE 617
Score = 52.8 bits (125), Expect = 3e-07
Identities = 50/222 (22%), Positives = 98/222 (44%), Gaps = 19/222 (8%)
Query: 16 DDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEANKKDEAPV 74
++ K + PE + K+ ++++ +K K K++ ++ AEA++ +K ++PV
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSP-------EKAKSPAKEEAKSPAEAKSPEKAKSPV 608
Query: 75 ADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEK 134
+ + E + + + ++ P KA EE K A + + + A S EK
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE---KEEAKSPEK 665
Query: 135 AGS---AETESATKASTDNSPSSKAED---APAKEEPKQADVPAAVTAAAATTPAAEDAA 188
A S AE +S KA + +K+ + +P KEE K + + A +P +
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725
Query: 189 AKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
K A+ P + S +E ++ ++ K E A+ + K E
Sbjct: 726 VKEEAKTPEKA--KSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765
Score = 51.6 bits (122), Expect = 6e-07
Identities = 56/232 (24%), Positives = 99/232 (42%), Gaps = 36/232 (15%)
Query: 7 RTKQVEKNDDDQKIEQDGIKPEDK-AHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
+T V+ + +++ P DK KA + ++ + + +K K K+D +A E E
Sbjct: 757 KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK---SPEKAKSPLKEDAKAPEKE 813
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQA 123
KK+E E+K + E K E KA TP E+K + + A ++
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPP-----KKAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Query: 124 APQAPASSEEKAGSAET--ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATT 181
AP+ P E+K + E ES +A + + K P KE P + +V
Sbjct: 869 APK-PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV----------- 916
Query: 182 PAAEDAAAKATAQPPTETGESSQAEENIEAVDETKP---KESARQDEGKEEE 230
K A+P +T + + ++ +A + +KP KE+A + + +EE
Sbjct: 917 --------KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Score = 50.4 bits (119), Expect = 1e-06
Identities = 46/197 (23%), Positives = 76/197 (38%), Gaps = 20/197 (10%)
Query: 54 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKK 113
EK++ AE ++ +K ++P + + E + +A + P +A EE K
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
Query: 114 GEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSP------SSKAEDAPAKEE 164
+ + + A + A S EKA S E E A SP S + +P K E
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR-- 222
K + A +P E+A + A+ P + S + +E K E A+
Sbjct: 688 AKSPE--------KAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 223 -QDEGKEEEPEADQEHA 238
++E K E E A
Sbjct: 740 VKEEAKSPEKAKSPEKA 756
Score = 50.1 bits (118), Expect = 2e-06
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 15/228 (6%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEAN 67
K EK + E +K +KA A + S + +K K K++ ++ AEA++
Sbjct: 565 KSPEKEEAKSPAE---VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621
Query: 68 KKDEA--PVADGVEKKGEGTTTAEA-APATGSKPD-EPGKAGETPSEEKKGEGDAATEQA 123
K+EA P +K + T EA +P P+ E K+ E K E + +
Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 124 AP-QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182
+P +A A S EKA S E A S + + S E+A + E+ K A T A +P
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
E+A + A+ P E ++ + +T KE AR K E
Sbjct: 740 VKEEAKSPEKAKSP----EKAKTLDVKSPEAKTPAKEEARSPADKFPE 783
Score = 50.1 bits (118), Expect = 2e-06
Identities = 54/224 (24%), Positives = 92/224 (41%), Gaps = 27/224 (12%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
K++ K ++ + ++ KP++ K K + T K EKKD +K
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT--EEKKD---------SK 860
Query: 69 KDEAPVADG----VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124
K+EAP + VE+K E +K +E + P+ EK+ A +
Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKE-----APAKVE 915
Query: 125 PQAPASSEEKAGSAETE-SATKASTDNSPSSKAEDAPAKEEPKQ--ADVPAAVTAAAATT 181
+ A +EK A+ E KA + P+ K E AP K++ K+ A P A
Sbjct: 916 VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975
Query: 182 PAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDE 225
+ +K ++P E E S + + ++KP E A +D+
Sbjct: 976 KEDDKTLSKEPSKPKAEKAEKSSSTDQ----KDSKPPEKATEDK 1015
Score = 47.0 bits (110), Expect = 1e-05
Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 17/196 (8%)
Query: 49 KKLKGEKKDDVQAAE-AEANKKDEAPVADGVEK--KGEGTTTAEAAPATGSKPDEPGKAG 105
+K K K++ ++ E A++ +K+EA + + K E + +A ++ P KA
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695
Query: 106 ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 165
EE K A ++ + A S EKA S E A SP + +P K +
Sbjct: 696 SPVKEEAKSPEKA---KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKS 752
Query: 166 KQADVPAAVTAAAATTPAAEDA---------AAKATAQPPTETGESSQA--EENIEAVDE 214
+ V + A TPA E+A AK+ + ++ E +++ +E+ +A ++
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK 812
Query: 215 TKPKESARQDEGKEEE 230
PK+ + KEEE
Sbjct: 813 EIPKKEEVKSPVKEEE 828
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 57.8 bits (138), Expect = 8e-09
Identities = 45/234 (19%), Positives = 96/234 (41%), Gaps = 10/234 (4%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
++ ++ ++D K E+ G +++ + K G+ + K + +KK++ + AEA+
Sbjct: 4784 EEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGG 4843
Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP------SEEKKGEGDAATEQ 122
+ E + + ++++ + K EP +A + P SE+K G D E+
Sbjct: 4844 QGEDKINEQIDERDYDENEVDPYHGNQEKVPEP-EALDLPDDLNLDSEDKNGGEDTDNEE 4902
Query: 123 AAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182
+ P +EK A E+ + T+ + +E P + D
Sbjct: 4903 GEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDD---KAEGEEEMDT 4959
Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
A+D A P + E Q+ E + + + E+ D+G + + E ++E
Sbjct: 4960 GADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEERE 5013
Score = 40.8 bits (94), Expect = 0.001
Identities = 42/184 (22%), Positives = 71/184 (38%), Gaps = 24/184 (13%)
Query: 53 GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 112
GE D+ + E + E P G E + G T E P EP E PSE+
Sbjct: 4895 GEDTDNEEGEEENPLEIKEKPEEAGHEAEERGET--ETDQNESQSPQEPE---EGPSEDD 4949
Query: 113 KGEGDAATEQAA----------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 162
K EG+ + A P+ + ++++ + + A + +N P+ + +
Sbjct: 4950 KAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEE 5009
Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
EE + +D V A E + Q E +++QA E A E KE +
Sbjct: 5010 EEREDSDTEEQV------PEALERKEHASCGQTGVENMQNTQAMELAGAAPE---KEQGK 5060
Query: 223 QDEG 226
++ G
Sbjct: 5061 EEHG 5064
Score = 38.5 bits (88), Expect = 0.005
Identities = 44/237 (18%), Positives = 91/237 (38%), Gaps = 23/237 (9%)
Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKG------EKKDDVQ 60
+ K+ ++ + G +P+++ + + + + RK+ E + Q
Sbjct: 4986 KDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQ 5045
Query: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSK-----PDEPGKAGETPSEEKKGE 115
A E ++ G E+ G G A A S + T S ++K
Sbjct: 5046 AMELAGAAPEKE---QGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRK-P 5101
Query: 116 GDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT 175
G A E++ ++ + +T+S + P ++ EDA A E KQ
Sbjct: 5102 GQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQ-------- 5153
Query: 176 AAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232
+ A D A+K Q ++G+ + EE + + +T+ +E + + ++ +PE
Sbjct: 5154 GSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPE 5210
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 56.2 bits (134), Expect = 2e-08
Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 12/185 (6%)
Query: 65 EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124
E+ K+++AP DG+ + +G S+ + GK + +E KK +G+
Sbjct: 67 ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE-DAEAELKKEDGEKEETTVG 125
Query: 125 PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ------ADVP---AAVT 175
Q +E+ S E+ K ST S KAE+ AK E Q D P A V
Sbjct: 126 SQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVE 185
Query: 176 AAAATTPAAEDAAAK--ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
A T + E+ + + +P + + E+ +AV E + K ++ +GKEE
Sbjct: 186 EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHG 245
Query: 234 DQEHA 238
+E A
Sbjct: 246 AKEEA 250
Score = 50.4 bits (119), Expect = 1e-06
Identities = 53/219 (24%), Positives = 81/219 (36%), Gaps = 43/219 (19%)
Query: 49 KKLKGEKKDDVQAA-EAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------- 100
K+ K +D + A + EAN DE V E G+ AE G K +
Sbjct: 70 KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129
Query: 101 PGKAGETPSEEKKGEGDAAT--------------------------EQAAPQAPASSEEK 134
G+ ET SE K+ E +T ++ P+A E+
Sbjct: 130 TGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDA 189
Query: 135 AGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 194
+++ E+ + P KA D AK E ++A V A E+A A
Sbjct: 190 KTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK-- 247
Query: 195 PPTETGESSQAEENIEAVDETKP-KESARQDEGKEEEPE 232
E + A+E E +E +P S Q++ E+EPE
Sbjct: 248 ------EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPE 280
Score = 47.8 bits (112), Expect = 9e-06
Identities = 46/195 (23%), Positives = 79/195 (40%), Gaps = 21/195 (10%)
Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108
KK GEK++ ++ +K+E ++ E T +E KA E
Sbjct: 113 KKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQ-----------KAEEKE 161
Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAG--SAETESATKASTDNSPSSKAEDAPAKEEPK 166
++ + G+ A ++ P+ A+ EE+ +++ E+ + P KA D AK E +
Sbjct: 162 AKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQ 221
Query: 167 QADVPAAVTAAA--------ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK 218
+A V A A A E+A AK A+ E S +EE + V++
Sbjct: 222 KAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEG 281
Query: 219 ESARQDEGKEEEPEA 233
+ EE PE+
Sbjct: 282 GAGVIPSSPEEWPES 296
Score = 47.0 bits (110), Expect = 1e-05
Identities = 52/220 (23%), Positives = 81/220 (36%), Gaps = 30/220 (13%)
Query: 44 GHITRKKLKGEKKDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSK---- 97
G + E ++ ++ E + ++ +P AD E G G E G
Sbjct: 4 GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63
Query: 98 -PDEPGKAGETPSE-----EKKGEGDAATE-------QAAPQAPASSEEKAGSAETESAT 144
P E GK + P+E E +GE + E +A + A +E K E E T
Sbjct: 64 PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETT 123
Query: 145 KASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-----PPTET 199
S + + + + KE ++ A+ A A ++ KA A P T
Sbjct: 124 VGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKAT 183
Query: 200 GE------SSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
E +SQ E T+PKE A +E K E +A
Sbjct: 184 VEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKA 223
Score = 43.5 bits (101), Expect = 2e-04
Identities = 56/228 (24%), Positives = 87/228 (38%), Gaps = 21/228 (9%)
Query: 21 EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKD--DVQAAEAEANKKDEAPVADGV 78
E G K E K+ + + S + +K K E+K+ +A+AN +D+ V
Sbjct: 128 EMTGRKEETKSEPKEAEEKEST---LASEKQKAEEKEAKPESGQKADANDRDKPEPKATV 184
Query: 79 EKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT----EQAAPQAPASSEEK 134
E++ T + E EP + + EE K E A +A P+ P EE
Sbjct: 185 EEEDAKTASQEETGQRKECSTEPKE--KATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
Query: 135 AGSAETESATKASTDN-------SPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187
A+ E+ K ++ SPS + E KE A V + +P E
Sbjct: 243 KHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGH 302
Query: 188 AAKATAQPP--TETGESS-QAEENIEAVDETKPKESARQDEGKEEEPE 232
P +G++S A E+ + P ES E KE+ PE
Sbjct: 303 NLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPE 350
Score = 40.8 bits (94), Expect = 0.001
Identities = 46/182 (25%), Positives = 69/182 (37%), Gaps = 8/182 (4%)
Query: 8 TKQVEK-NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEA 66
T+ EK D++ K E ED+A + K+ K++ A EAE
Sbjct: 205 TEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEP 264
Query: 67 NKKDEAPVADGVEKKGEGTTTAEAAPATGSK-PDEPGKAGETPSEEKKGEGDAATEQAAP 125
E D VEK+ EG A P++ + P+ P G S + G A+ Q +P
Sbjct: 265 GSPSEEQEQD-VEKEPEGG--AGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSP 321
Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT---AAAATTP 182
A SS + ES + + APA+ +A A+ AA+ P
Sbjct: 322 SASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGP 381
Query: 183 AA 184
A
Sbjct: 382 TA 383
Score = 36.6 bits (83), Expect = 0.020
Identities = 34/124 (27%), Positives = 51/124 (41%), Gaps = 16/124 (12%)
Query: 114 GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAA 173
GE D + E A E+K G + T + ++P APA+E A A
Sbjct: 7 GESDCSAE-----AREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAG--KA 59
Query: 174 VTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEE-EPE 232
+ T ++ A P E G S++ + +DE K ES R+ GKE+ E E
Sbjct: 60 INEGPPTESGKQEKA-------PAEDGMSAELQGEANGLDEVK-VESQREAGGKEDAEAE 111
Query: 233 ADQE 236
+E
Sbjct: 112 LKKE 115
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 55.1 bits (131), Expect = 5e-08
Identities = 57/236 (24%), Positives = 88/236 (37%), Gaps = 29/236 (12%)
Query: 12 EKNDDDQKIE--QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 69
+ +++DQK + Q G+KP+ KA KA K K K D ++E E K
Sbjct: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPK------------KAKSSDSDSDSSSEDEP-PK 181
Query: 70 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG-DAATEQAAPQAP 128
++ P V K + T A PA + GKA + S D + E+ A P
Sbjct: 182 NQKPKITPVTVKAQ--TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
Query: 129 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ-----------ADVPAAVTAA 177
+ K A+T SS +ED+ + EE +Q + VP
Sbjct: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299
Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
+ + Q P E+ E S E + + +E KP A + + P A
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355
Score = 52.8 bits (125), Expect = 3e-07
Identities = 53/233 (22%), Positives = 85/233 (36%), Gaps = 30/233 (12%)
Query: 14 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK---- 69
+ DD + E+ P+ K +A + T + K +D + E E KK
Sbjct: 226 SSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTR-KSSSSEDSSSDEEEEQKKPMKN 284
Query: 70 ------DEAPVADGVEKKGEGTT----TAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119
P + KK GT E S D ++ + EEKK A
Sbjct: 285 KPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV 344
Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAA 179
+A + P + + S+++ + + D +PS PA ++ PA T + A
Sbjct: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK-----PAGTTKNSSNKPAVTTKSPA 399
Query: 180 TTPAAED----------AAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
PAA KA + E SS+ E+ + V TKPK +A+
Sbjct: 400 VKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452
Score = 50.8 bits (120), Expect = 1e-06
Identities = 58/267 (21%), Positives = 114/267 (42%), Gaps = 46/267 (17%)
Query: 7 RTKQVEKNDDDQKIEQDGIK--PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEA 64
+ K + +D E++ ++ P KA A ++ G K + ++ +
Sbjct: 79 KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLP-PGKAAAKASESSSSEESSDDDD 137
Query: 65 EANKKDEAPVADGVEKKGEGTTTAEAAP--ATGSKPDEPGKAGETPSEEKKGEGDAATEQ 122
E ++K + PV GV+ + + A+A P A S D + + P + +K + T +
Sbjct: 138 EEDQKKQ-PVQKGVKPQAKA---AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVK 193
Query: 123 AAPQAPAS--------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
A +AP + KA S+ + S++ +S+D+S KA P K PK+ V A
Sbjct: 194 AQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKK-QVVAKA 252
Query: 175 TAAAATTPAAEDAAAKATAQ-------------------------PPTETGESSQAEENI 209
AATTP + ++++ ++ PP + +Q +
Sbjct: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK-- 310
Query: 210 EAVDETKPKESARQDEGKEEEPEADQE 236
+AV++ +P ES+ +D E + +++E
Sbjct: 311 KAVEKQQPVESS-EDSSDESDSSSEEE 336
Score = 46.6 bits (109), Expect = 2e-05
Identities = 49/228 (21%), Positives = 95/228 (41%), Gaps = 16/228 (7%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
+Q ++ +D E D E+K K TK S + K + ++++++++
Sbjct: 316 QQPVESSEDSSDESDSSSEEEK--KPPTKAVVS-KATTKPPPAKKAAESSSDSSDSDSSE 372
Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAP 128
DEAP K GTT + + K P + G T +A
Sbjct: 373 DDEAP------SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKA---DS 423
Query: 129 ASSEEKAGSAETESATKASTDNSPSSKAEDA---PAKEEPKQADVPAAVTAAAATTPAAE 185
+SSEE++ S+E E K P + A+ A PAK+ P+ + ++ + ++++ E
Sbjct: 424 SSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEE 483
Query: 186 DAAAKATAQPPTE-TGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232
+ A + P + G ++ ++ + + S+ D+ EEE E
Sbjct: 484 KTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531
Score = 41.6 bits (96), Expect = 6e-04
Identities = 48/233 (20%), Positives = 91/233 (39%), Gaps = 19/233 (8%)
Query: 13 KNDDDQKIEQDGIKPEDKAHK--AATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 70
K D E+ E+K K A TK +A+ + ++ + A +A +D
Sbjct: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALS-----------LPAKQAPQGSRD 468
Query: 71 EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130
+ +D + E T+++A + G A P+ KKG+ +++ ++ +
Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEE 528
Query: 131 SEEK---AGSAETES--ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
EEK GS ++ A S + + KA +EE ++ V+ + + +
Sbjct: 529 EEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588
Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
+ AAK A+ P Q + + + S+ +EEE E D A
Sbjct: 589 NEAAK-EAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVA 640
Score = 37.4 bits (85), Expect = 0.012
Identities = 36/174 (20%), Positives = 61/174 (35%), Gaps = 7/174 (4%)
Query: 65 EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124
E + PVA +KK + + +++ P K P++ A +A+
Sbjct: 65 ERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKAS 124
Query: 125 PQAPASSEEKAGSAETESATKASTDNS--PSSKAEDAP---AKEEPKQADVPAAVTAAAA 179
+ SSEE + + E K P +KA AP AK +D +
Sbjct: 125 ESS--SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKN 182
Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
P KA + P + ++ N +A + S+ + EEE A
Sbjct: 183 QKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA 236
Score = 30.4 bits (67), Expect = 1.4
Identities = 24/134 (17%), Positives = 53/134 (39%), Gaps = 8/134 (5%)
Query: 103 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 162
K+ + P + + G A + + + SE+ + E A P+ + P K
Sbjct: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
K ++ ++++ +++D + + P + G QA+ + K +S
Sbjct: 119 AAAKASE-------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDS-D 170
Query: 223 QDEGKEEEPEADQE 236
D E+EP +Q+
Sbjct: 171 SDSSSEDEPPKNQK 184
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 53.5 bits (127), Expect = 2e-07
Identities = 60/248 (24%), Positives = 94/248 (37%), Gaps = 20/248 (8%)
Query: 9 KQVEKNDDDQKIEQDG---------IKPEDKAHKAATKIQASFRGHITRKKLKGE--KKD 57
K+VE++ +D+++ +D + P+ K KAA T+K KK
Sbjct: 22 KEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKA 81
Query: 58 DV---QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE--PGKAGETPSEEK 112
V + A A KK P +G T +A AT K P K + K
Sbjct: 82 AVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAK 141
Query: 113 KGEGDAATEQAAPQAPASSE-EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 171
K + D + + + E E E E A + +P+S+ ED E+ + D
Sbjct: 142 KEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDD 201
Query: 172 A---AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKE 228
+ A TTPA AAK E EE+ E D+ ++ D+ +
Sbjct: 202 EEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDD 261
Query: 229 EEPEADQE 236
EE E ++E
Sbjct: 262 EEEEEEEE 269
Score = 31.2 bits (69), Expect = 0.82
Identities = 36/159 (22%), Positives = 55/159 (34%), Gaps = 20/159 (12%)
Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGE----GTTTAEAAPATGSKPDEPG-- 102
K K KK+D E + +++DE D E + E A AAPA+ + DE
Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDED 194
Query: 103 --------------KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 148
+A ET + K +A A EE+ E + +
Sbjct: 195 DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE 254
Query: 149 DNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187
D+ E+ +EE + P A AA +A
Sbjct: 255 DDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEA 293
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 53.1 bits (126), Expect = 2e-07
Identities = 44/197 (22%), Positives = 74/197 (37%), Gaps = 15/197 (7%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA----GET 107
+GE + + + E E ++ E +G E++GEG E G +E G+ GE
Sbjct: 890 EGEGEGEEEEGEGEGEEEGEG---EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946
Query: 108 PSEEKKGEGDAATEQAA----PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE 163
EE++GE + E+ + EE G E E + + E+ E
Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006
Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVDETKPKE 219
E + + E+ + + E GE + EEN +E + +E
Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
Query: 220 SARQDEGKEEEPEADQE 236
Q+ G+EE D E
Sbjct: 1067 GKYQETGEEENERQDGE 1083
Score = 52.0 bits (123), Expect = 5e-07
Identities = 52/237 (21%), Positives = 88/237 (37%), Gaps = 24/237 (10%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN- 67
++ E+ + + K E +G + E + K + + R K+ KGE++ D E E
Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG---KEEKGEEEGDQGEGEEEETE 802
Query: 68 -----KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQ 122
K++ V G ++G+G E G + + G+ E EE++GEG E
Sbjct: 803 GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG 862
Query: 123 AAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182
+ EE G E E + E+ E ++ +
Sbjct: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE------------G 910
Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD---EGKEEEPEADQE 236
E+ + + E GE EE E E E ++ EG+EEE E + E
Sbjct: 911 EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967
Score = 50.4 bits (119), Expect = 1e-06
Identities = 55/241 (22%), Positives = 90/241 (37%), Gaps = 22/241 (9%)
Query: 5 MRRTKQVEKN--DDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAA 62
M R + EK + ++ ++DG + E K + +GH + + E+ + +
Sbjct: 686 MERPGEGEKELAEKEEWKKRDGEEQEQKERE---------QGHQKERNQEMEEGGEEEHG 736
Query: 63 EAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPG--KAGETPSEEKKG--EGDA 118
E E + D + EK+GEG E G + E G K E +E+KG EGD
Sbjct: 737 EGEEEEGDRE---EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793
Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178
E + EEK E E + E+ +EE + +
Sbjct: 794 G-EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE 852
Query: 179 ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGK---EEEPEADQ 235
E+ + + E GE EE E E + + ++EG+ EEE E +
Sbjct: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912
Query: 236 E 236
E
Sbjct: 913 E 913
Score = 50.1 bits (118), Expect = 2e-06
Identities = 48/240 (20%), Positives = 90/240 (37%), Gaps = 12/240 (5%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
++ E+ + ++ E +G + E + + + + G + +GE+ + E +
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886
Query: 69 KDEAPVADGVEKKGEGTTTAEA-----APATGSKPDEPGKAGETPSEEKKGEG---DAAT 120
+E +G E++GEG E K +E G+ GE EE++GEG D
Sbjct: 887 GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946
Query: 121 EQAAPQAPASSEEKAGSAETESATKASTD----NSPSSKAEDAPAKEEPKQADVPAAVTA 176
E + EE+ G E E + + + E +EE ++
Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006
Query: 177 AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
E+ + + E GE EE E E + KE ++ + E E ++E
Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
Score = 35.8 bits (81), Expect = 0.033
Identities = 32/155 (20%), Positives = 60/155 (38%), Gaps = 16/155 (10%)
Query: 21 EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEK 80
E++G + + + + G + +GE++ + + E E ++E +G E+
Sbjct: 934 EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993
Query: 81 KGE--------GTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSE 132
+GE G E G + +E GE EE +GEG E+ +
Sbjct: 994 EGEEEGEEEGEG---EEEGEGEGEEEEEGEVEGEVEGEEGEGEG----EEEEGEEEGEER 1046
Query: 133 EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 167
EK G E E+ + K ++ +E +Q
Sbjct: 1047 EKEGEGE-ENRRNREEEEEEEGKYQETGEEENERQ 1080
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 53.1 bits (126), Expect = 2e-07
Identities = 53/195 (27%), Positives = 82/195 (42%), Gaps = 19/195 (9%)
Query: 25 IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEG 84
+ E A +A ++Q+ T ++ E +Q A DE P A+ E
Sbjct: 495 LSEETSAEEAHAEVQSPLAEETTAEEASAE----IQLLAAIEAPADETP-AEAQSPLSE- 548
Query: 85 TTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESA 143
T+AE APA P G + E P E + G+ T +EE + + + +A
Sbjct: 549 ETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETT----------AEEASAAIQLLAA 598
Query: 144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKATAQPPTETGES 202
T+AS + +P+ + + PA+E P + P A A A P AE+A A+ P E
Sbjct: 599 TEASAEEAPA-EVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAE 657
Query: 203 SQAEENIEAVDETKP 217
Q EA E +P
Sbjct: 658 VQPPPAEEAPAEVQP 672
Score = 51.6 bits (122), Expect = 6e-07
Identities = 53/192 (27%), Positives = 86/192 (44%), Gaps = 18/192 (9%)
Query: 54 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPA-------TGSKPDEPGKAGE 106
E+ ++Q + A +EAP E TTAE A A T DE
Sbjct: 435 EEARELQLSTAMETPAEEAPTEFQSPLPKE--TTAEEASAEIQLLAATEPPADETPAEAR 492
Query: 107 TPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE--SATKASTDNSPSSKAEDAPAKEE 164
+P E+ +A E +P A ++ E+A SAE + +A +A D +P+ +P EE
Sbjct: 493 SPLSEETSAEEAHAEVQSPLAEETTAEEA-SAEIQLLAAIEAPADETPAE--AQSPLSEE 549
Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 224
+ PA V + +A + E+A + QPP +GE + AEE A+ E++ ++
Sbjct: 550 TSAEEAPAEVQSPSAKGVSIEEAPLE--LQPP--SGEETTAEEASAAIQLLAATEASAEE 605
Query: 225 EGKEEEPEADQE 236
E +P +E
Sbjct: 606 APAEVQPPPAEE 617
Score = 46.6 bits (109), Expect = 2e-05
Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 12/226 (5%)
Query: 22 QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV--QAAEAEANKKDEAPVADGVE 79
Q + E A +A+ +IQ + E + + + + EA+ + ++P+A+
Sbjct: 458 QSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETT 517
Query: 80 KKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAG--- 136
+ E + + A + DE ++P E+ +A E +P A S E+A
Sbjct: 518 AE-EASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL 576
Query: 137 ---SAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKAT 192
S E +A +AS + A +A A+E P + P A A A P AE+A A+
Sbjct: 577 QPPSGEETTAEEASAAIQLLA-ATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 635
Query: 193 AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
P E Q EA E +P A + + + P A++ A
Sbjct: 636 PPPAEEAPAEVQPPPAEEAPAEVQP-PPAEEAPAEVQPPPAEEAPA 680
Score = 39.7 bits (91), Expect = 0.002
Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 9/133 (6%)
Query: 92 PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNS 151
PA G+ + P K EE + + AP+ E+A + +A + + +
Sbjct: 400 PAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPR------EEARELQLSTAMETPAEEA 453
Query: 152 PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTET-GESSQAEENIE 210
P+ +P +E + A + AAT P A++ A+A + ET E + AE
Sbjct: 454 PTE--FQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSP 511
Query: 211 AVDETKPKESARQ 223
+ET +E++ +
Sbjct: 512 LAEETTAEEASAE 524
Score = 33.5 bits (75), Expect = 0.17
Identities = 56/250 (22%), Positives = 95/250 (38%), Gaps = 38/250 (15%)
Query: 19 KIEQDGIKPEDKAHKAATKIQAS----FRGHITRKKLKGEKKDDVQAAEAEANKKDEAPV 74
K ++D +K HK++ KI AS F+ + G+K + E K +
Sbjct: 176 KSKEDALK-----HKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLL 230
Query: 75 ADGVEKKGEGTTTAE--AAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS-- 130
D + ++ E A S EP + P++ + + AT +A P+ PA
Sbjct: 231 EDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPR-PAEET 289
Query: 131 ------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA------AA 178
S E+ AE +A ++ AE+AP E P + P+A + A
Sbjct: 290 HVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAE 349
Query: 179 ATTPAAEDAAAK----ATAQPPTETGESSQAEENIEAVDETK--------PKESARQDEG 226
P+AE++ ++ PP E S + I + K P E A ++
Sbjct: 350 ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAP 409
Query: 227 KEEEPEADQE 236
+ EP +E
Sbjct: 410 AKVEPPTVEE 419
>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
Length = 437
Score = 52.8 bits (125), Expect = 3e-07
Identities = 50/209 (23%), Positives = 81/209 (38%), Gaps = 28/209 (13%)
Query: 56 KDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGE 115
KD + AEA +++P G E K + + +++ + D P K+G K G
Sbjct: 134 KDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGS 193
Query: 116 GDAATEQAAP-----------QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-- 162
+ E P Q P K+G+ E S + ++D+P K
Sbjct: 194 SKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVV 253
Query: 163 -EEPKQAD--VPAAVTAAAATTPAAE--DAAAKATAQP---PTETGES----SQAEENI- 209
E+P + D P + + P A+ A K P TE+GE S +E +
Sbjct: 254 PEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVK 313
Query: 210 --EAVDETKPKESARQDEGKEEEPEADQE 236
E ++ +PKE+ D G EE +E
Sbjct: 314 SSEPTEDVEPKEAEDDDTGPEEGSPPKEE 342
Score = 46.2 bits (108), Expect = 2e-05
Identities = 62/262 (23%), Positives = 102/262 (38%), Gaps = 55/262 (20%)
Query: 19 KIEQDGIKPEDKAHKAATKIQASFR-GHITRKKLKGEK-KDDVQAAEAEANKKDEAPVAD 76
K E+ G++P A +T S R G T+ + + KD + AEA ++ P
Sbjct: 27 KQEEAGVRPS--AGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKS 84
Query: 77 GVEKKGE---------------GTT-------------TAEAAPATGSKPDEPGKAG--- 105
G E K + G+T T+++ P + D GK+G
Sbjct: 85 GAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEA 144
Query: 106 ETPSEEKKGEG-DAATEQAAPQAPASSEEKAGSAETESATKAST--DNSPSSKAEDAPAK 162
+TP + G +A T++ +P S + +S T D S S AED K
Sbjct: 145 QTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPK 204
Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKES 220
+ P + + A TP + A Q P + S AEE ++ ++ P++
Sbjct: 205 DVPNK-------SGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQP 257
Query: 221 ARQDEGK--------EEEPEAD 234
+R+D K +E P+AD
Sbjct: 258 SRKDHSKPISNPSDNKELPKAD 279
Score = 32.3 bits (72), Expect = 0.37
Identities = 27/145 (18%), Positives = 56/145 (38%), Gaps = 11/145 (7%)
Query: 88 AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS 147
A A P ++ + +AG PS G+ +T P+ S+ GS ++ +
Sbjct: 15 AGAVPLLATESVKQEEAGVRPSA-----GNVSTH------PSLSQRPGGSTKSHPEPQTP 63
Query: 148 TDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE 207
D+ S AE ++ P ++ A ++ AE K + ++++
Sbjct: 64 KDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDST 123
Query: 208 NIEAVDETKPKESARQDEGKEEEPE 232
+ + PK+S + + + PE
Sbjct: 124 SKSHPELQTPKDSTGKSGAEAQTPE 148
>gi|117938759 GNAS complex locus XLas [Homo sapiens]
Length = 1037
Score = 52.4 bits (124), Expect = 3e-07
Identities = 61/213 (28%), Positives = 76/213 (35%), Gaps = 15/213 (7%)
Query: 14 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAP 73
N D I DG P K A K + + R + + + E D AE K
Sbjct: 324 NMDSPPIALDG--PPIKVSGAPDKRERAERPPVEEEAAEMEGAADA----AEGGKVPSPG 377
Query: 74 VADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA-PASSE 132
T A AAPA + PD +G TP + G A + A A P S
Sbjct: 378 YGSPAAGAASADTAARAAPAAPADPD----SGATPEDPDSGTAPADPDSGAFAADPDSGA 433
Query: 133 EKAGSAETESATKASTDNSPSS-KAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAK 190
A A+ +S P S A DAPA +P P A A AAA T AA A A
Sbjct: 434 APAAPADPDSGAAPDAPADPDSGAAPDAPA--DPDAGAAPEAPAAPAAAETRAAHVAPAA 491
Query: 191 ATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
A PT S+ + P AR+
Sbjct: 492 PDAGAPTAPAASATRAAQVRRAASAAPASGARR 524
Score = 44.3 bits (103), Expect = 9e-05
Identities = 46/178 (25%), Positives = 67/178 (37%), Gaps = 27/178 (15%)
Query: 53 GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 112
G +D + A A+ A AD A A P +G+ PD P + +
Sbjct: 405 GATPEDPDSGTAPADPDSGAFAAD---PDSGAAPAAPADPDSGAAPDAPADPDSGAAPDA 461
Query: 113 KGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA 172
+ DA AP APA++E +A +P + A APA + A V
Sbjct: 462 PADPDAGAAPEAPAAPAAAETRAAHV---------APAAPDAGAPTAPAASATRAAQVRR 512
Query: 173 AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES-ARQDEGKEE 229
A +AA A+ A K +PP+ I+A D P+ + A GK E
Sbjct: 513 AASAAPAS-----GARRKIHLRPPS---------PEIQAADPPTPRPTRASAWRGKSE 556
Score = 37.0 bits (84), Expect = 0.015
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 9/139 (6%)
Query: 98 PDEPGKAGETPSEEKKGEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSPSS 154
PD+ +A P EE+ E + A + A +P AG+A ++A +A+ + +
Sbjct: 343 PDKRERAERPPVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAP--AAPA 400
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
+ E+P PA + A AA A A P + + A+ + A
Sbjct: 401 DPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAA-- 458
Query: 215 TKPKESARQDEGKEEEPEA 233
P A D G E A
Sbjct: 459 --PDAPADPDAGAAPEAPA 475
Score = 36.6 bits (83), Expect = 0.020
Identities = 41/156 (26%), Positives = 55/156 (35%), Gaps = 11/156 (7%)
Query: 89 EAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 148
EAA G+ G +P G A+ + AA APA+ + A E +
Sbjct: 357 EAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTA 416
Query: 149 DNSPSSKAEDAPAKEEPKQADVPAAV----TAAAATTPAAEDAAAKATAQPPTETGESSQ 204
P S A A +P PAA + AA PA D+ A A + G + +
Sbjct: 417 PADPDSGAFAA----DPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPE 472
Query: 205 AEENIEAVDETKPKE--SARQDEGKEEEPEADQEHA 238
A A ET+ A D G P A A
Sbjct: 473 APA-APAAAETRAAHVAPAAPDAGAPTAPAASATRA 507
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 51.6 bits (122), Expect = 6e-07
Identities = 55/202 (27%), Positives = 82/202 (40%), Gaps = 21/202 (10%)
Query: 46 ITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAG 105
+TR + K EK+ D + E E + E + + P+ G
Sbjct: 1590 LTRMQQK-EKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLE 1648
Query: 106 ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 165
PS +K GD E AP +EEK E AT S + P+S+ AP E+
Sbjct: 1649 SAPSALEKTTGDKTVE-----APLVTEEKT----VEPAT-VSEEAKPASEPAPAPV-EQL 1697
Query: 166 KQADVP--------AAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE-AVDETK 216
+Q D+P AA+ A ++ D A+PPT SQAE N++ D T+
Sbjct: 1698 EQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQ 1757
Query: 217 PKESARQDEGKEEEPEADQEHA 238
P Q + EP+A++ A
Sbjct: 1758 PLSKPAQKSEEANEPKAEKPDA 1779
Score = 45.1 bits (105), Expect = 6e-05
Identities = 47/213 (22%), Positives = 84/213 (39%), Gaps = 13/213 (6%)
Query: 28 EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAE-AEANKKDEAPVADGVEKKGEGTT 86
E + +AA RG + + + +++++ +A E AE K E + +K
Sbjct: 1935 ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK------ 1988
Query: 87 TAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKA 146
TA G K K T E G + + P ++EE+AGS + A
Sbjct: 1989 TAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA 2048
Query: 147 STDNSPSSKA-----EDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGE 201
TD +P A E PA E+ ++ + + A +A A P +
Sbjct: 2049 GTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQ 2108
Query: 202 SSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
+ + E + AV K ES ++++G + ++D
Sbjct: 2109 AGERESGVVAVSPEK-SESPQKEDGLSSQLKSD 2140
Score = 42.4 bits (98), Expect = 4e-04
Identities = 47/210 (22%), Positives = 72/210 (34%), Gaps = 8/210 (3%)
Query: 11 VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 70
+EK D+ +E + E A +A + E+ + V K+
Sbjct: 1654 LEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPV--EQLEQVDLPPGADPDKE 1711
Query: 71 EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130
A + GVE+ G + P +KP PG + E D+ T+ + A S
Sbjct: 1712 AAMMPAGVEEGSSG----DQPPYLDAKPPTPGASFSQAESNVDPEPDS-TQPLSKPAQKS 1766
Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAK 190
E AE AT A + + KAE AP + P D+ AA + +K
Sbjct: 1767 EEANEPKAEKPDAT-ADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSK 1825
Query: 191 ATAQPPTETGESSQAEENIEAVDETKPKES 220
Q + E +D K K S
Sbjct: 1826 TPVQAAAVSIVEKPVTRKSERIDREKLKRS 1855
Score = 41.6 bits (96), Expect = 6e-04
Identities = 47/193 (24%), Positives = 72/193 (37%), Gaps = 17/193 (8%)
Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108
+K KG +K + NKK APV V + + + AA G+ P E P
Sbjct: 2327 RKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANE-GTTVQHP----EAP 2381
Query: 109 SEEKKGEGDAATEQAA--------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 160
EEK+ E +T + P SS+E S E + TKAS + AP
Sbjct: 2382 QEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEI--SVEERTPTKASVPPDLPPPPQPAP 2439
Query: 161 AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220
EEP+ ++ + TP ++ + T P+ T + P
Sbjct: 2440 VDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL--PSVTAAKLSPPVASGGIPHQSPPTK 2497
Query: 221 ARQDEGKEEEPEA 233
+ ++EEP A
Sbjct: 2498 VTEWITRQEEPRA 2510
Score = 32.0 bits (71), Expect = 0.48
Identities = 39/178 (21%), Positives = 61/178 (34%), Gaps = 15/178 (8%)
Query: 60 QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119
+ A A+A +++ VA EK + S P +P K E G A
Sbjct: 2103 RGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEA 2162
Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAA 179
T+ A + E SA+ A ++P A + + K A + AAA
Sbjct: 2163 TQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPE----DRDKPAHQASETELAAA 2218
Query: 180 TTPAAEDAAAKAT--AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235
D + + PP GES + +P A+ + EE E D+
Sbjct: 2219 IGSIINDISGEPENFPAPPPYPGESQ---------TDLQPPAGAQALQPSEEGMETDE 2267
Score = 29.6 bits (65), Expect = 2.4
Identities = 17/42 (40%), Positives = 18/42 (42%)
Query: 152 PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATA 193
P+SKA P KE K D AA T A P A A A
Sbjct: 3221 PASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPA 3262
Score = 28.5 bits (62), Expect = 5.3
Identities = 17/85 (20%), Positives = 35/85 (41%)
Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
G +P+ + + S + + ++ A QA + +GS ++ + + +S SS
Sbjct: 230 GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAA 179
+ D+ D PA +AA
Sbjct: 290 TSSDSSDSSSSSSDDSPARSVQSAA 314
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 51.6 bits (122), Expect = 6e-07
Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 9/184 (4%)
Query: 54 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE---PGKAGETPSE 110
EK + + EA +K+ E EG TT E P+E K G E
Sbjct: 865 EKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIE 924
Query: 111 EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADV 170
+ + EG E + EEKA + E E + ++ S ++ +P ++E
Sbjct: 925 KFEDEGAGFEESSET---GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAE 981
Query: 171 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
A + A+ D A+ E GE+ Q+EE DE E AR++E + E+
Sbjct: 982 ADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEE---ADEEDKAEDAREEEYEPEK 1038
Query: 231 PEAD 234
EA+
Sbjct: 1039 MEAE 1042
Score = 49.7 bits (117), Expect = 2e-06
Identities = 57/241 (23%), Positives = 95/241 (39%), Gaps = 26/241 (10%)
Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
K+ + +D+K E++ KP+ + K K ++++K E K +++ E + K
Sbjct: 640 KETKVKPEDKKEEKE--KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697
Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQA 127
K+ E K E E + EP K + P + KK ++T + +
Sbjct: 698 KEVKKETPPKEVKKE--VKKEEKKEVKKEEKEPKKEIKKLPKDAKK----SSTPLSEAKK 751
Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187
PA+ + K E + P K + K+E K A+ AA ATT A A
Sbjct: 752 PAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAA 811
Query: 188 AAKATAQPP----------------TETGESSQAEENIEAVDETKPKESARQDEGKEEEP 231
A A P T+ E +AEE ++ + KP+ +DE K +E
Sbjct: 812 AGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE-VDVTKDIKPQLELIEDEEKLKET 870
Query: 232 E 232
E
Sbjct: 871 E 871
Score = 46.6 bits (109), Expect = 2e-05
Identities = 54/194 (27%), Positives = 84/194 (43%), Gaps = 21/194 (10%)
Query: 57 DDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK---K 113
DD++ E E +E+ E+K E T AE G + + +P+E++ K
Sbjct: 921 DDIEKFEDEGAGFEESSETGDYEEKAE-TEEAEEPEEDGEEHVCVSASKHSPTEDEESAK 979
Query: 114 GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS-----KAEDAPAKE-EPKQ 167
E DA + ++ AS +++A E+ K + S KAEDA +E EP++
Sbjct: 980 AEADAYIREKR-ESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEK 1038
Query: 168 A---DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAV-DETKPKES--- 220
D AV AA AE+ T P + G S E ++ DET P S
Sbjct: 1039 MEAEDYVMAVVDKAAEAGGAEEQYGFLTT-PTKQLGAQSPGREPASSIHDETLPGGSESE 1097
Query: 221 --ARQDEGKEEEPE 232
A +E +E++PE
Sbjct: 1098 ATASDEENREDQPE 1111
Score = 39.7 bits (91), Expect = 0.002
Identities = 56/253 (22%), Positives = 95/253 (37%), Gaps = 37/253 (14%)
Query: 8 TKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
+K V K ++ E + +K K +K + + K +K E K V E +
Sbjct: 554 SKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKD---KPIKTETKPSVTEKEVPS- 609
Query: 68 KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 127
K++ +PV V +K +AA K + K + E++K + + A ++ +
Sbjct: 610 KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKE--DKT 667
Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAE-----DAPAKE------------------E 164
P EEK E + K + + + P KE E
Sbjct: 668 PIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKE 727
Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR-- 222
PK+ A ++TP +E A A +P E S ++++ A KPKE +
Sbjct: 728 PKKEIKKLPKDAKKSSTPLSE-AKKPAALKPKVPKKEESVKKDSVAA---GKPKEKGKIK 783
Query: 223 --QDEGKEEEPEA 233
+ EGK E A
Sbjct: 784 VIKKEGKAAEAVA 796
Score = 33.9 bits (76), Expect = 0.13
Identities = 37/191 (19%), Positives = 68/191 (35%), Gaps = 33/191 (17%)
Query: 76 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE--QAAPQAPASSEE 133
DG G+ + + E S P+ G + ET ++ + D +T + A + + +
Sbjct: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTP-DTSTYCYETAEKITRTPQA 2054
Query: 134 KAGSAETESATKASTDNSPSSKAEDAP-----------------------------AKEE 164
S ET + SPS +D A EE
Sbjct: 2055 STYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEE 2114
Query: 165 P-KQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
P ++++ P + A P + + PPT ES+ ++ + + ET+ S
Sbjct: 2115 PTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITA 2174
Query: 224 DEGKEEEPEAD 234
D + E E++
Sbjct: 2175 DANIDSEDESE 2185
Score = 32.0 bits (71), Expect = 0.48
Identities = 31/125 (24%), Positives = 49/125 (39%), Gaps = 8/125 (6%)
Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAA-PATGSKPDEPGKAGET 107
K LK + K+ + + K +PV KK +G + AA P + K
Sbjct: 2233 KALKKDLKEKTKTKKPGTKTKSSSPV-----KKSDGKSKPLAASPKPAGLKESSDKVSRV 2287
Query: 108 PSEEKKGEGD-AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPK 166
S +KK + AA P+ A+ E+ ET++A AS S + + K
Sbjct: 2288 ASPKKKESVEKAAKPTTTPEVKAARGEEKDK-ETKNAANASASKSAKTATAGPGTTKTTK 2346
Query: 167 QADVP 171
+ VP
Sbjct: 2347 SSAVP 2351
Score = 29.3 bits (64), Expect = 3.1
Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 18/120 (15%)
Query: 25 IKPEDKAHKAATKIQASFRGHITRKKLK---------GEKKDDVQAAEAEANKKDEAPVA 75
+K + K K TK ++S + K K G K+ + + + KK E+
Sbjct: 2239 LKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKES--- 2295
Query: 76 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKA 135
VEK + TTT E A G + D+ K S K A T A P +++ A
Sbjct: 2296 --VEKAAKPTTTPEVKAARGEEKDKETKNAANASASK----SAKTATAGPGTTKTTKSSA 2349
Score = 27.7 bits (60), Expect = 9.1
Identities = 30/138 (21%), Positives = 48/138 (34%), Gaps = 7/138 (5%)
Query: 102 GKAGETP-----SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKA 156
G AG TP ++EK + P P S E E E A+ + D
Sbjct: 1329 GSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSE 1388
Query: 157 EDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETK 216
P ++ +A + +A+D A+ A+ P E E S + + + V
Sbjct: 1389 SPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFE--EKSGKQGSPDQVSPVS 1446
Query: 217 PKESARQDEGKEEEPEAD 234
S + K+E D
Sbjct: 1447 EMTSTSLYQDKQEGKSTD 1464
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 51.6 bits (122), Expect = 6e-07
Identities = 56/248 (22%), Positives = 96/248 (38%), Gaps = 29/248 (11%)
Query: 6 RRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
++ EK + +K E + E K K A K + T+K++KG K++ V+ A+
Sbjct: 182 KKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEK-----TKKEVKGGKQEKVKQTAAK 236
Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPG--------------KAGETPSEE 111
+ + P K E +AA + + D+ K G++P+
Sbjct: 237 VKEVQKTP-----SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA-DV 170
TEQA+ PAS + E + A K T + + ED K E + A DV
Sbjct: 292 PP----LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
Query: 171 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
A+ T A A E E S+ + V++ K K+ ++++ E
Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
Query: 231 PEADQEHA 238
+EH+
Sbjct: 408 KSPKKEHS 415
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/206 (24%), Positives = 83/206 (40%), Gaps = 42/206 (20%)
Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
+GEKK + +E KK++ + ++KK E T + + EPGKA ET
Sbjct: 313 EGEKKKAEKKVTSETKKKEK----EDIKKKSEKETAIDV------EKKEPGKASET---- 358
Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAED------APAKEEP 165
K+G T + A QA A +EK +++ K + P K ++ PAK
Sbjct: 359 KQG-----TVKIAAQAAAKKDEK--KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411
Query: 166 KQADVPAAVTAAAATTPAAEDAAAKA---------------TAQPPTETGESSQAEENIE 210
K+ VP+ A T A E+ A + T + +S + ++
Sbjct: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471
Query: 211 AVDETKPKESARQDEGKEEEPEADQE 236
+ K KE KE+EPE ++
Sbjct: 472 DKEPIKGKEEKVPASLKEKEPETKKD 497
Score = 29.6 bits (65), Expect = 2.4
Identities = 42/177 (23%), Positives = 70/177 (39%), Gaps = 27/177 (15%)
Query: 17 DQKIEQDG--IKPED------KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
D+K+ + G +KP+ K K +I+ + I+ +K++ K+D V+ + ++
Sbjct: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAIS-EKVQIHKQDIVKPEKTVSHG 555
Query: 69 KDEAPV-----ADGVEKKGEGTTTAEAA---------PATGSKPDEPGKAGETPSEEKKG 114
K E V A +EK + T +A KP G + T S +KK
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
Query: 115 EGDAATEQAAPQAPASSEEKAG----SAETESATKASTDNSPSSKAEDAPAKEEPKQ 167
E + EEK S + + TKA S ED PA ++ K+
Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 49.7 bits (117), Expect = 2e-06
Identities = 49/208 (23%), Positives = 83/208 (39%), Gaps = 35/208 (16%)
Query: 28 EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK--KDEAPVADGVEKKGEGT 85
ED K K +A ++ + E ++D + EA K KDE DG E K G
Sbjct: 106 EDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKN-GN 164
Query: 86 TTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATK 145
E A K E GK GE + KG G+ E+ + ++ G + K
Sbjct: 165 EKGEDA-----KEKEDGKKGE----DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGK 215
Query: 146 ASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQA 205
D + +D KE+ K+ + ED E+ +
Sbjct: 216 EKGDKK---EGKDVKVKEDEKERE------------DGKEDEGGNEE--------EAGKE 252
Query: 206 EENIEAVDETKPKESARQDEGKEEEPEA 233
+E+++ +E K ++ ++D+GK+EEP++
Sbjct: 253 KEDLKEEEEGKEEDEIKEDDGKKEEPQS 280
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 49.7 bits (117), Expect = 2e-06
Identities = 57/254 (22%), Positives = 106/254 (41%), Gaps = 34/254 (13%)
Query: 6 RRTKQVEKNDDDQKIEQDGIKP---------EDKAHKAATKIQASFR--GHITRKKLK-- 52
RR K ++++D+++ E+ G + ED ++ AS G + + K K
Sbjct: 180 RRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAP 239
Query: 53 ----GEKKDDVQAAEAEANKKDEAPVADG--VEKKGEGTTTAEAAPATGSKP-------- 98
G KK + ++ EA + + +G V+ +G+++++ P + +K
Sbjct: 240 LAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPK 299
Query: 99 --DEPGKAGETPSEEKKGEGDAATEQ--AAPQAPASSEEKAGSAETESATKASTDNSPSS 154
DE + E EEK E D E+ AP K S E++S+ ++ D+ SS
Sbjct: 300 GVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASS 359
Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
A K PK+ P+ ++ + P A +T+ T +S+ E+ + V E
Sbjct: 360 ALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSS--TLRAAASKLEQG-KRVSE 416
Query: 215 TKPKESARQDEGKE 228
+ R D G +
Sbjct: 417 MPAAKRLRLDTGPQ 430
Score = 39.7 bits (91), Expect = 0.002
Identities = 35/196 (17%), Positives = 78/196 (39%), Gaps = 25/196 (12%)
Query: 48 RKKLKGEKKDDVQAAEAEANKKDEAPVA-----DGVEKKGEGTTTA--EAAPATGSKPDE 100
+++LK + +D+ + + + ++ + + D +E + + + E +K
Sbjct: 179 QRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKA 238
Query: 101 PGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 160
P G ++KKG D A E + + + + S +S+ P SKA+
Sbjct: 239 PLAKGGRKKKKKKGSDDEAFEDSD-----DGDFEGQEVDYMSDGSSSSQEEPESKAKAPQ 293
Query: 161 AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220
+E PK D + D++ ++ + P E + + E+ E K ++
Sbjct: 294 QEEGPKGVDEQS-------------DSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKD 340
Query: 221 ARQDEGKEEEPEADQE 236
+ ++ EE + D E
Sbjct: 341 SSEESDSSEESDIDSE 356
Score = 38.9 bits (89), Expect = 0.004
Identities = 42/177 (23%), Positives = 79/177 (44%), Gaps = 30/177 (16%)
Query: 62 AEAEANKKDEAPVADGVEKKGEGTTTAEAA-PATGSKPDEPGKAGETPSEEKK------- 113
++A+A +++E P GV+++ + + +E P K +E K TP E+K+
Sbjct: 287 SKAKAPQQEEGP--KGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEE 344
Query: 114 ----------GEGDAATEQAAPQAPASSEEK--AGSAETES--ATKASTDNSPSSKAEDA 159
E +A A + P E K GS+ S T ++ S SS A
Sbjct: 345 SDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAA 404
Query: 160 PAKEE--PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
+K E + +++PAA T P + + K+T QPP +G+++ +++ ++
Sbjct: 405 ASKLEQGKRVSEMPAAKRLRLDTGP--QSLSGKSTPQPP--SGKTTPNSGDVQVTED 457
>gi|7662162 ALEX2 protein [Homo sapiens]
Length = 632
Score = 48.9 bits (115), Expect = 4e-06
Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%)
Query: 26 KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 82
KP+++A + +A R T G AEAE +DEA D G E
Sbjct: 40 KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99
Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 123
++AEA GS+ E AG P E G +A
Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159
Query: 124 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 168
AP +AP +E + TE+A P +K +AP P +A
Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219
Query: 169 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 211
VPA T AAA T AAE AA KAT P TG +A A
Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277
Query: 212 VDETKPKESAR-----QDEGKEEEPEADQ 235
V + K R + +GK+ + E D+
Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306
Score = 34.3 bits (77), Expect = 0.097
Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%)
Query: 85 TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 138
T AEA PAT + P A E+P G +A ++A P A + KA SA
Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274
Query: 139 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 193
+ K T + K + +K E + + AAAA +A A
Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334
Query: 194 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 231
P +E GES + E + ++ ET+ + R+ ++ P
Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374
>gi|29540562 ALEX2 protein [Homo sapiens]
Length = 632
Score = 48.9 bits (115), Expect = 4e-06
Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%)
Query: 26 KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 82
KP+++A + +A R T G AEAE +DEA D G E
Sbjct: 40 KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99
Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 123
++AEA GS+ E AG P E G +A
Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159
Query: 124 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 168
AP +AP +E + TE+A P +K +AP P +A
Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219
Query: 169 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 211
VPA T AAA T AAE AA KAT P TG +A A
Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277
Query: 212 VDETKPKESAR-----QDEGKEEEPEADQ 235
V + K R + +GK+ + E D+
Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306
Score = 34.3 bits (77), Expect = 0.097
Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%)
Query: 85 TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 138
T AEA PAT + P A E+P G +A ++A P A + KA SA
Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274
Query: 139 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 193
+ K T + K + +K E + + AAAA +A A
Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334
Query: 194 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 231
P +E GES + E + ++ ET+ + R+ ++ P
Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 48.9 bits (115), Expect = 4e-06
Identities = 56/241 (23%), Positives = 94/241 (39%), Gaps = 28/241 (11%)
Query: 18 QKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEA-EANKKDEA-PVA 75
QK E+ + E++ K+A + S + R+ L + + A+ A E + K +A P +
Sbjct: 413 QKKEKKDKERENEKEKSALARERSLK---KRQSLPASPRARLSASTASELSPKSKARPSS 469
Query: 76 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE----KKGEGDAATEQAAPQAPASS 131
+ P P P G T S + +K E + A P+ + S
Sbjct: 470 PSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQS 529
Query: 132 EEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAA------- 184
+ +A S E ESA AS SP+ AP ++E A+ P AA T+P A
Sbjct: 530 KRRA-SNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETP--TDAAVLTSPPAPAPPVTP 586
Query: 185 ---------EDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235
+ A + A+ + E + EE + + K + +E E A++
Sbjct: 587 SKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAER 646
Query: 236 E 236
E
Sbjct: 647 E 647
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.294 0.113 0.293
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,070,716
Number of Sequences: 37866
Number of extensions: 520723
Number of successful extensions: 9483
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 528
Number of HSP's successfully gapped in prelim test: 1193
Number of HSP's that attempted gapping in prelim test: 4386
Number of HSP's gapped (non-prelim): 4487
length of query: 238
length of database: 18,247,518
effective HSP length: 99
effective length of query: 139
effective length of database: 14,498,784
effective search space: 2015330976
effective search space used: 2015330976
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.