Guide to the Human Genome
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Search of human proteins with 4503911

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503911 growth associated protein 43 isoform 2 [Homo
sapiens]
         (238 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens]      468   e-132
gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens]    446   e-126
gi|30795231 brain abundant, membrane attached signal protein 1 [...    66   2e-11
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    66   3e-11
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    66   3e-11
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    66   3e-11
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    66   3e-11
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    64   9e-11
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    64   9e-11
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              64   1e-10
gi|153070260 myristoylated alanine-rich protein kinase C substra...    62   6e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    61   7e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    61   7e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     60   2e-09
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       58   8e-09
gi|157738619 smoothelin-like 1 [Homo sapiens]                          56   2e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    55   5e-08
gi|55956788 nucleolin [Homo sapiens]                                   54   2e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    53   2e-07
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       53   2e-07
gi|42518068 trans-golgi network protein 2 [Homo sapiens]               53   3e-07
gi|117938759 GNAS complex locus XLas [Homo sapiens]                    52   3e-07
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]     52   6e-07
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          52   6e-07
gi|104526627 triadin [Homo sapiens]                                    52   6e-07
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               50   2e-06
gi|156104891 general transcription factor IIF, polypeptide 1, 74...    50   2e-06
gi|7662162 ALEX2 protein [Homo sapiens]                                49   4e-06
gi|29540562 ALEX2 protein [Homo sapiens]                               49   4e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    49   4e-06

>gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens]
          Length = 238

 Score =  468 bits (1203), Expect = e-132
 Identities = 238/238 (100%), Positives = 238/238 (100%)

Query: 1   MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ 60
           MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ
Sbjct: 1   MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ 60

Query: 61  AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT 120
           AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT
Sbjct: 61  AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT 120

Query: 121 EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT 180
           EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT
Sbjct: 121 EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT 180

Query: 181 TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
           TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
Sbjct: 181 TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238


>gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens]
          Length = 274

 Score =  446 bits (1147), Expect = e-126
 Identities = 228/229 (99%), Positives = 229/229 (100%)

Query: 10  QVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 69
           +VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK
Sbjct: 46  RVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 105

Query: 70  DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
           DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA
Sbjct: 106 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165

Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189
           SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA
Sbjct: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 225

Query: 190 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
           KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
Sbjct: 226 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274


>gi|30795231 brain abundant, membrane attached signal protein 1
           [Homo sapiens]
          Length = 227

 Score = 66.2 bits (160), Expect = 2e-11
 Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%)

Query: 49  KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108
           KK KG   +D +A E +   +  A   +G  K+ E    AE A A   K ++P +  E  
Sbjct: 7   KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 168
           +EEK+GE DAA   A  +AP +  EK   A    A          +    A   E PK A
Sbjct: 66  AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123

Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 224
           +  AA   +AA  PAA +  +K   +P      ++ A +  ++      ++KP  S    
Sbjct: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181

Query: 225 EGKE 228
             KE
Sbjct: 182 SSKE 185



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%)

Query: 13  KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72
           K   DQ  E    + E +   AA K +A         K + EK +    A+AE  K  E 
Sbjct: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106

Query: 73  P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
              A G    GE    AEAA  PA  + P     AGE PS+E   EG+    + AP APA
Sbjct: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTE-APAAPA 158

Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189
           + E K+  A    +   S++ +PSSK             + PAA T A ++TP A+  AA
Sbjct: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204

Query: 190 KATAQPPTE 198
            A    P E
Sbjct: 205 SAEEPKPVE 213



 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 35/222 (15%)

Query: 14  NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAP 73
           N +D+K ++     + KA  AAT+ + + +          E +    A  AEA +  E P
Sbjct: 13  NVNDEKAKEK----DKKAEGAATEEEGTPK----------ESEPQAAAEPAEAKEGKEKP 58

Query: 74  VAD----GVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
             D      EK+GE    A    A  ++P++   A E  +E  K       EQAAP  PA
Sbjct: 59  DQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA---PEQEQAAP-GPA 114

Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA---------AAAT 180
           +  E   +AE  +A   S   +P++  E +  + EPK+ + PAA  A         A+ +
Sbjct: 115 AGGEAPKAAEAAAAPAESA--APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172

Query: 181 TPAAEDAAAKATAQPPTETGESS--QAEENIEAVDETKPKES 220
            P + +AA  +   P      SS  +A+    + +E KP E+
Sbjct: 173 KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEA 214



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 11/147 (7%)

Query: 103 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT----KASTDNSPSSKAED 158
           K G   ++EK  E D   E AA +   + +E    A  E A     K   D     KAE+
Sbjct: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68

Query: 159 -------APAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA 211
                  A AKEE  +A+      AA A     +    +  A  P   GE+ +A E   A
Sbjct: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAA 128

Query: 212 VDETKPKESARQDEGKEEEPEADQEHA 238
             E+    +  +   +E EP+  +  A
Sbjct: 129 PAESAAPAAGEEPSKEEGEPKKTEAPA 155



 Score = 37.0 bits (84), Expect = 0.015
 Identities = 30/84 (35%), Positives = 41/84 (48%), Gaps = 13/84 (15%)

Query: 68  KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 127
           KK EAP A   ++     T ++ APA+ SK   PG +   PS +   E  AATE  AP +
Sbjct: 149 KKTEAPAAPAAQE-----TKSDGAPASDSK---PGSSEAAPSSK---ETPAATE--APSS 195

Query: 128 PASSEEKAGSAETESATKASTDNS 151
              ++  A SAE     +A   NS
Sbjct: 196 TPKAQGPAASAEEPKPVEAPAANS 219


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)

Query: 49  KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
           KK + E +   + +E+E    A  + +   ++ + +    +  A+  P  G+ P  PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323

Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
           G   S+ K G+ +  +E       +SSEE + S E   A KA      S K     A  A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376

Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
           PAKE P++   PA       T PA   A A    +    + E S +EE  EA  + KP  
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431

Query: 220 SARQ 223
            A Q
Sbjct: 432 KAPQ 435



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 33  KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
           K AT       G +  +   G+ ++D +++  E++  ++E P A  + + K  G T+   
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372

Query: 88  -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
                A+ +P  G+ P  PGK G   ++ + G+ +  ++        SS E++ S E   
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424

Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
           A    +  +P  +A  APAKE P++   PA          AA+    K      + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482

Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
               E + A++  + K   +  + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)

Query: 59  VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
           V A +A+++ +D +  +D  + +G+           + + + +PA  + P  PGK G+  
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
            + K G    A     P+  + S E+   +E E+     +    S K     A  APAK 
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309

Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
            P +   PA    A A        A++  A  P E  ESS +EE+ ++ +ET   ++  Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361



 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%)

Query: 35   ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
            +T +QA     + + KL  E +   +A E+  + +D +  + G E+ GEG   A++A   
Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134

Query: 95   GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
                      G TPS  +    + A E +     A S+       T   T A   NS +S
Sbjct: 1135 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1182

Query: 155  KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
            KA        PK    P+     ++T  A +D   K  A+P    G  S      EA   
Sbjct: 1183 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1231

Query: 215  TKPKESARQDEG 226
            T P++S +  +G
Sbjct: 1232 TTPQKSRKPKKG 1243



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)

Query: 52  KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
           K E+  +  + E+  +   E P A    ++       +A P +      P KAG    + 
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
           K  +    +E +   + ++  E+A +A T +  K +     T   P      A AK  P 
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659

Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
           +    A   A  AT+PA    A     Q P E   SS+  ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)

Query: 27  PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
           P  K   AA ++Q   +   +R     E+ D  + A A  N     P+    + K   +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511

Query: 87  TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
                   G+ P  PGK G           E  SE    E   +++   P A A ++E  
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571

Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
                              KAG    +   +   DNS SS+     A  E    + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627

Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
           TAA A                 TT +A+ A  +   Q P + G ++    +  AV     
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687

Query: 216 KPKESARQDEGKEEEPE 232
           +P E +   E  + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)

Query: 8   TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           ++    + D+  +E +  +KP   KA   +TK   + +      K+ G+    V+     
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
             K+ + P  +  E   EG+ + E APA G++     KA E   + +     A       
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314

Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
             PA   +    A    A K   D+  SS+      E+ PA +   QA      +   AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374

Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
           + PA E     A   PP +TG    A    +A    +  +S+ ++   EEE  A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)

Query: 26   KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
            K + KA+ AA +  +     S  G +     + +++   +      N ++   +A G   
Sbjct: 787  KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 78   VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
            V   G+   TA  A  TG + D      E+ SEE+       K  G     +AA  APA 
Sbjct: 847  VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904

Query: 131  SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
               + G+A T    K     + + K +D+ +  E   +D   PAAVT+A           
Sbjct: 905  ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 178  -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
                    A TPA   AA+   KA A   T    SS++E+                N+  
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 212  VDETKP--------------KESARQDEGKEEEPEADQ 235
            +    P              KES+R  +GK++E  A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 55/256 (21%), Positives = 94/256 (36%), Gaps = 34/256 (13%)

Query: 12   EKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKKDDV 59
            E++D +++ E    +KP  K H+    +  +             G       +  K+DD 
Sbjct: 873  EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932

Query: 60   QAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGETPS 109
             ++  E++   EAP A    +                   A PA       P KA  + S
Sbjct: 933  GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992

Query: 110  EEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
              +    ++  E   P          ++     +A    A KAS   + SSK     +  
Sbjct: 993  TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052

Query: 162  -KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETKPKE 219
             K+E     V +AV    AT+P +    AK T +    +  E  QA +  E+ D++  ++
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS--ED 1110

Query: 220  SARQDEGKEEEPEADQ 235
            S+    G EE+ E  Q
Sbjct: 1111 SSDSSSGSEEDGEGPQ 1126



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)

Query: 10  QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
           + EK  D+ +  ++     D  +A  A T  QA     I + K   +K +   +A+    
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656

Query: 68  KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
               APV  G +   K G  T+ A ++PA      +P E   + E    E++  G A T 
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712

Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
             A       + KA S                           AE +  +++S + S S 
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
           +A  +PA+ +       A    AAA  P+A+           AAA+A  + P++      
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832

Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
                     G +S            + +    +D G  EE    +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881



 Score = 31.2 bits (69), Expect = 0.82
 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)

Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
           ++K E DAA +    +       + +S EE+   AET  AT      + S    D P+  
Sbjct: 62  KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
           KE+ K     A  T  +   PA     A        + +A+P   T   S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)

Query: 55   KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
            K D   +  +    KD+    DG ++          +P TG K    G   +   + KKG
Sbjct: 1187 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1243

Query: 115  EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
             G+      A Q+                   +S  K  +   E   K   D +  S  +
Sbjct: 1244 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1303

Query: 158  DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
               +++     D PAA T  +       A E   A  + +  + T +     +      +
Sbjct: 1304 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1363

Query: 215  TKPKESARQDEGKEEEPEAD 234
             K  + +   +G ++EPE +
Sbjct: 1364 EKKGKGSLGSQGAKDEPEEE 1383


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)

Query: 49  KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
           KK + E +   + +E+E    A  + +   ++ + +    +  A+  P  G+ P  PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323

Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
           G   S+ K G+ +  +E       +SSEE + S E   A KA      S K     A  A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376

Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
           PAKE P++   PA       T PA   A A    +    + E S +EE  EA  + KP  
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431

Query: 220 SARQ 223
            A Q
Sbjct: 432 KAPQ 435



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 33  KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
           K AT       G +  +   G+ ++D +++  E++  ++E P A  + + K  G T+   
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372

Query: 88  -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
                A+ +P  G+ P  PGK G   ++ + G+ +  ++        SS E++ S E   
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424

Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
           A    +  +P  +A  APAKE P++   PA          AA+    K      + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482

Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
               E + A++  + K   +  + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)

Query: 59  VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
           V A +A+++ +D +  +D  + +G+           + + + +PA  + P  PGK G+  
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
            + K G    A     P+  + S E+   +E E+     +    S K     A  APAK 
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309

Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
            P +   PA    A A        A++  A  P E  ESS +EE+ ++ +ET   ++  Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)

Query: 35   ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
            +T +QA     + + KL  E +   +A E+  + +D +  + G E+ GEG   A++A   
Sbjct: 1114 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1172

Query: 95   GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
            G  P       ET  EE       A E +     A S+       T   T A   NS +S
Sbjct: 1173 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1219

Query: 155  KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
            KA        PK    P+     ++T  A +D   K  A+P    G  S      EA   
Sbjct: 1220 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1268

Query: 215  TKPKESARQDEG 226
            T P++S +  +G
Sbjct: 1269 TTPQKSRKPKKG 1280



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)

Query: 52  KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
           K E+  +  + E+  +   E P A    ++       +A P +      P KAG    + 
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
           K  +    +E +   + ++  E+A +A T +  K +     T   P      A AK  P 
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659

Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
           +    A   A  AT+PA    A     Q P E   SS+  ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)

Query: 27  PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
           P  K   AA ++Q   +   +R     E+ D  + A A  N     P+    + K   +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511

Query: 87  TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
                   G+ P  PGK G           E  SE    E   +++   P A A ++E  
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571

Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
                              KAG    +   +   DNS SS+     A  E    + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627

Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
           TAA A                 TT +A+ A  +   Q P + G ++    +  AV     
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687

Query: 216 KPKESARQDEGKEEEPE 232
           +P E +   E  + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)

Query: 8   TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           ++    + D+  +E +  +KP   KA   +TK   + +      K+ G+    V+     
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
             K+ + P  +  E   EG+ + E APA G++     KA E   + +     A       
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314

Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
             PA   +    A    A K   D+  SS+      E+ PA +   QA      +   AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374

Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
           + PA E     A   PP +TG    A    +A    +  +S+ ++   EEE  A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)

Query: 26   KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
            K + KA+ AA +  +     S  G +     + +++   +      N ++   +A G   
Sbjct: 787  KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 78   VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
            V   G+   TA  A  TG + D      E+ SEE+       K  G     +AA  APA 
Sbjct: 847  VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904

Query: 131  SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
               + G+A T    K     + + K +D+ +  E   +D   PAAVT+A           
Sbjct: 905  ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 178  -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
                    A TPA   AA+   KA A   T    SS++E+                N+  
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 212  VDETKP--------------KESARQDEGKEEEPEADQ 235
            +    P              KES+R  +GK++E  A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)

Query: 10  QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
           + EK  D+ +  ++     D  +A  A T  QA     I + K   +K +   +A+    
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656

Query: 68  KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
               APV  G +   K G  T+ A ++PA      +P E   + E    E++  G A T 
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712

Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
             A       + KA S                           AE +  +++S + S S 
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
           +A  +PA+ +       A    AAA  P+A+           AAA+A  + P++      
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832

Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
                     G +S            + +    +D G  EE    +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881



 Score = 32.7 bits (73), Expect = 0.28
 Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%)

Query: 66   ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
            ++ K+ + ++DG +++G  T  ++  PA+             P  +   +  A     A 
Sbjct: 1041 SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1088

Query: 126  QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
               A ++  +G         A++  S S +A+      +PK  +V  A T A  ++  +E
Sbjct: 1089 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1147

Query: 186  DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
            D++  ++     E GE  Q  ++   +  T  +     +E   E  E D
Sbjct: 1148 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1194



 Score = 31.2 bits (69), Expect = 0.82
 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)

Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
           ++K E DAA +    +       + +S EE+   AET  AT      + S    D P+  
Sbjct: 62  KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
           KE+ K     A  T  +   PA     A        + +A+P   T   S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)

Query: 55   KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
            K D   +  +    KD+    DG ++          +P TG K    G   +   + KKG
Sbjct: 1224 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1280

Query: 115  EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
             G+      A Q+                   +S  K  +   E   K   D +  S  +
Sbjct: 1281 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1340

Query: 158  DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
               +++     D PAA T  +       A E   A  + +  + T +     +      +
Sbjct: 1341 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1400

Query: 215  TKPKESARQDEGKEEEPEAD 234
             K  + +   +G ++EPE +
Sbjct: 1401 EKKGKGSLGSQGAKDEPEEE 1420


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)

Query: 49  KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
           KK + E +   + +E+E    A  + +   ++ + +    +  A+  P  G+ P  PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323

Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
           G   S+ K G+ +  +E       +SSEE + S E   A KA      S K     A  A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376

Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
           PAKE P++   PA       T PA   A A    +    + E S +EE  EA  + KP  
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431

Query: 220 SARQ 223
            A Q
Sbjct: 432 KAPQ 435



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 33  KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
           K AT       G +  +   G+ ++D +++  E++  ++E P A  + + K  G T+   
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372

Query: 88  -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
                A+ +P  G+ P  PGK G   ++ + G+ +  ++        SS E++ S E   
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424

Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
           A    +  +P  +A  APAKE P++   PA          AA+    K      + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482

Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
               E + A++  + K   +  + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)

Query: 59  VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
           V A +A+++ +D +  +D  + +G+           + + + +PA  + P  PGK G+  
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
            + K G    A     P+  + S E+   +E E+     +    S K     A  APAK 
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309

Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
            P +   PA    A A        A++  A  P E  ESS +EE+ ++ +ET   ++  Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)

Query: 35   ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
            +T +QA     + + KL  E +   +A E+  + +D +  + G E+ GEG   A++A   
Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134

Query: 95   GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
            G  P       ET  EE       A E +     A S+       T   T A   NS +S
Sbjct: 1135 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1181

Query: 155  KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
            KA        PK    P+     ++T  A +D   K  A+P    G  S      EA   
Sbjct: 1182 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1230

Query: 215  TKPKESARQDEG 226
            T P++S +  +G
Sbjct: 1231 TTPQKSRKPKKG 1242



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)

Query: 52  KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
           K E+  +  + E+  +   E P A    ++       +A P +      P KAG    + 
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
           K  +    +E +   + ++  E+A +A T +  K +     T   P      A AK  P 
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659

Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
           +    A   A  AT+PA    A     Q P E   SS+  ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)

Query: 27  PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
           P  K   AA ++Q   +   +R     E+ D  + A A  N     P+    + K   +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511

Query: 87  TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
                   G+ P  PGK G           E  SE    E   +++   P A A ++E  
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571

Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
                              KAG    +   +   DNS SS+     A  E    + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627

Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
           TAA A                 TT +A+ A  +   Q P + G ++    +  AV     
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687

Query: 216 KPKESARQDEGKEEEPE 232
           +P E +   E  + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)

Query: 8   TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           ++    + D+  +E +  +KP   KA   +TK   + +      K+ G+    V+     
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
             K+ + P  +  E   EG+ + E APA G++     KA E   + +     A       
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314

Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
             PA   +    A    A K   D+  SS+      E+ PA +   QA      +   AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374

Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
           + PA E     A   PP +TG    A    +A    +  +S+ ++   EEE  A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)

Query: 26   KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
            K + KA+ AA +  +     S  G +     + +++   +      N ++   +A G   
Sbjct: 787  KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 78   VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
            V   G+   TA  A  TG + D      E+ SEE+       K  G     +AA  APA 
Sbjct: 847  VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904

Query: 131  SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
               + G+A T    K     + + K +D+ +  E   +D   PAAVT+A           
Sbjct: 905  ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 178  -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
                    A TPA   AA+   KA A   T    SS++E+                N+  
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 212  VDETKP--------------KESARQDEGKEEEPEADQ 235
            +    P              KES+R  +GK++E  A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 55/256 (21%), Positives = 94/256 (36%), Gaps = 34/256 (13%)

Query: 12   EKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKKDDV 59
            E++D +++ E    +KP  K H+    +  +             G       +  K+DD 
Sbjct: 873  EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932

Query: 60   QAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGETPS 109
             ++  E++   EAP A    +                   A PA       P KA  + S
Sbjct: 933  GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992

Query: 110  EEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
              +    ++  E   P          ++     +A    A KAS   + SSK     +  
Sbjct: 993  TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052

Query: 162  -KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETKPKE 219
             K+E     V +AV    AT+P +    AK T +    +  E  QA +  E+ D++  ++
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS--ED 1110

Query: 220  SARQDEGKEEEPEADQ 235
            S+    G EE+ E  Q
Sbjct: 1111 SSDSSSGSEEDGEGPQ 1126



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)

Query: 10  QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
           + EK  D+ +  ++     D  +A  A T  QA     I + K   +K +   +A+    
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656

Query: 68  KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
               APV  G +   K G  T+ A ++PA      +P E   + E    E++  G A T 
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712

Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
             A       + KA S                           AE +  +++S + S S 
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
           +A  +PA+ +       A    AAA  P+A+           AAA+A  + P++      
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832

Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
                     G +S            + +    +D G  EE    +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881



 Score = 31.2 bits (69), Expect = 0.82
 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)

Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
           ++K E DAA +    +       + +S EE+   AET  AT      + S    D P+  
Sbjct: 62  KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
           KE+ K     A  T  +   PA     A        + +A+P   T   S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)

Query: 55   KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
            K D   +  +    KD+    DG ++          +P TG K    G   +   + KKG
Sbjct: 1186 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1242

Query: 115  EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
             G+      A Q+                   +S  K  +   E   K   D +  S  +
Sbjct: 1243 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1302

Query: 158  DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
               +++     D PAA T  +       A E   A  + +  + T +     +      +
Sbjct: 1303 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1362

Query: 215  TKPKESARQDEGKEEEPEAD 234
             K  + +   +G ++EPE +
Sbjct: 1363 EKKGKGSLGSQGAKDEPEEE 1382


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)

Query: 49  KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104
           KK + E +   + +E+E    A  + +   ++ + +    +  A+  P  G+ P  PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323

Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159
           G   S+ K G+ +  +E       +SSEE + S E   A KA      S K     A  A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376

Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219
           PAKE P++   PA       T PA   A A    +    + E S +EE  EA  + KP  
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431

Query: 220 SARQ 223
            A Q
Sbjct: 432 KAPQ 435



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 33  KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
           K AT       G +  +   G+ ++D +++  E++  ++E P A  + + K  G T+   
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372

Query: 88  -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
                A+ +P  G+ P  PGK G   ++ + G+ +  ++        SS E++ S E   
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424

Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
           A    +  +P  +A  APAKE P++   PA          AA+    K      + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482

Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
               E + A++  + K   +  + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)

Query: 59  VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108
           V A +A+++ +D +  +D  + +G+           + + + +PA  + P  PGK G+  
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
            + K G    A     P+  + S E+   +E E+     +    S K     A  APAK 
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309

Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
            P +   PA    A A        A++  A  P E  ESS +EE+ ++ +ET   ++  Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361



 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 27/205 (13%)

Query: 47  TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------ 100
           T  ++K EK++D +++E E++  +EA  +    K     T A+A PA    P        
Sbjct: 750 TVTQVKAEKQEDSESSEEESDS-EEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808

Query: 101 PGKA--------GETPSEEKKGEGDAATEQAAPQAPAS--SEEKAGSAETESATKASTDN 150
           PGK           +PS+ K    +        + PAS  S  KA +   ++ T    D+
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868

Query: 151 SPSSKAEDAPAKEEPKQADVPAAVT--AAAATTPAAEDAAAKATAQPPTETGESSQAEEN 208
             S +  D+  + E      P+  T    AA  PA E     A   PP +TG S      
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS------ 922

Query: 209 IEAVDETKPKESARQDEGKEEEPEA 233
             A    K  +S    E  + + EA
Sbjct: 923 --AAQAGKQDDSGSSSEESDSDGEA 945



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)

Query: 52  KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
           K E+  +  + E+  +   E P A    ++       +A P +      P KAG    + 
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
           K  +    +E +   + ++  E+A +A T +  K +     T   P      A AK  P 
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659

Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
           +    A   A  AT+PA    A     Q P E   SS+  ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)

Query: 27  PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
           P  K   AA ++Q   +   +R     E+ D  + A A  N     P+    + K   +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511

Query: 87  TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
                   G+ P  PGK G           E  SE    E   +++   P A A ++E  
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571

Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
                              KAG    +   +   DNS SS+     A  E    + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627

Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
           TAA A                 TT +A+ A  +   Q P + G ++    +  AV     
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687

Query: 216 KPKESARQDEGKEEEPE 232
           +P E +   E  + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%)

Query: 8   TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           ++    + D+  +E +  +KP   KA   +TK   + +      K+ G+    V+     
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
             K+ + P  +  E   EG+ + E APA G++     KA E   + +     A       
Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314

Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179
             PA   +    A    A K   D+  SS+      E+ PA +   QA      +   AA
Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374

Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
           + PA E     A   PP +TG    A    +A    +  +S+ ++   EEE  A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)

Query: 10  QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
           + EK  D+ +  ++     D  +A  A T  QA     I + K   +K +   +A+    
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656

Query: 68  KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
               APV  G +   K G  T+ A ++PA      +P E   + E    E++  G A T 
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712

Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
             A       + KA S                           AE +  +++S + S S 
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
           +A  +PA+ +       A    AAA  P+A+           AAA+A  + P++      
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832

Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
                     G +S            + +    +D G  EE    +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 16/104 (15%)

Query: 56  KDDVQAAEAEANKKDEAPVADGVEKKGE------GTTTAEAAPATGSKPDEPGKAGETPS 109
           ++D  ++E E++ ++EA     V+  G+          A+ +P  G+ P  PGK G  PS
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTG--PS 922

Query: 110 EEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPS 153
             + G+ D         + +SSEE     E  +A  ++ D   S
Sbjct: 923 AAQAGKQD--------DSGSSSEESDSDGEAPAAVTSAQDQESS 958



 Score = 35.8 bits (81), Expect = 0.033
 Identities = 43/169 (25%), Positives = 70/169 (41%), Gaps = 20/169 (11%)

Query: 26  KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
           K + KA+ AA +  +     S  G +     + +++   +      N ++   +A G   
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 78  VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
           V   G+   TA  A  TG + D      E+ SEE+       K  G     +AA  APA 
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904

Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA 177
              + G+A T    K     + + K +D+ +  E   +D   PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA 952



 Score = 31.2 bits (69), Expect = 0.82
 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)

Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161
           ++K E DAA +    +       + +S EE+   AET  AT      + S    D P+  
Sbjct: 62  KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207
           KE+ K     A  T  +   PA     A        + +A+P   T   S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 64.3 bits (155), Expect = 9e-11
 Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%)

Query: 59  VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 108
           V A +A+++ +D +  +D   VE K           +  A+  P  G+ P  PGKAG   
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
           S+ K G+ +  +E       +SSEE + S E   A KA      S K     A  APAKE
Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303

Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
            P++   PA       T PA   A A    +    + E S +EE  EA  + KP   A Q
Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 33  KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
           K AT       G +  +   G+ ++D +++  E++  ++E P A  + + K  G T+   
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295

Query: 88  -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
                A+ +P  G+ P  PGK G   ++ + G+ +  ++        SS E++ S E   
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347

Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
           A    +  +P  +A  APAKE P++   PA          AA+    K      + + ES
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405

Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
               E + A++  + K   +  + K
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430



 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%)

Query: 35   ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
            +T +QA     + + KL  E +   +A E+  + +D +  + G E+ GEG   A++A   
Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095

Query: 95   GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
                      G TPS  +    + A E +     A S+       T   T A   NS +S
Sbjct: 1096 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1143

Query: 155  KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
            KA        PK    P+     ++T  A +D   K  A+P    G  S      EA   
Sbjct: 1144 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1192

Query: 215  TKPKESARQDEG 226
            T P++S +  +G
Sbjct: 1193 TTPQKSRKPKKG 1204



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)

Query: 52  KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
           K E+  +  + E+  +   E P A    ++       +A P +      P KAG    + 
Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
           K  +    +E +   + ++  E+A +A T +  K +     T   P      A AK  P 
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582

Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
           +    A   A  AT+PA    A     Q P E   SS+  ++ E
Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)

Query: 27  PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
           P  K   AA ++Q   +   +R     E+ D  + A A  N     P+    + K   +T
Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434

Query: 87  TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
                   G+ P  PGK G           E  SE    E   +++   P A A ++E  
Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494

Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
                              KAG    +   +   DNS SS+     A  E    + PAA+
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550

Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
           TAA A                 TT +A+ A  +   Q P + G ++    +  AV     
Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610

Query: 216 KPKESARQDEGKEEEPE 232
           +P E +   E  + E E
Sbjct: 611 RPAEDSSSSEESDSEEE 627



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)

Query: 26  KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
           K + KA+ AA +  +     S  G +     + +++   +      N ++   +A G   
Sbjct: 710 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 769

Query: 78  VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
           V   G+   TA  A  TG + D      E+ SEE+       K  G     +AA  APA 
Sbjct: 770 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 827

Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
              + G+A T    K     + + K +D+ +  E   +D   PAAVT+A           
Sbjct: 828 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886

Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
                   A TPA   AA+   KA A   T    SS++E+                N+  
Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946

Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235
           +    P              KES+R  +GK++E  A Q
Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 984



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%)

Query: 72  APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 131
           A    G+   G+  +++E   ++  + D   KA E   + +     A         PA  
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243

Query: 132 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 185
            +    A    A K   D+  SS+      E+ PA +   QA      +   AA+ PA E
Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303

Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
                A   PP +TG    A    +A    +  +S+ ++   EEE  A
Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 52/228 (22%), Positives = 74/228 (32%), Gaps = 21/228 (9%)

Query: 7   RTKQVEKNDDDQKIEQDGIKPEDKAHKA-ATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           + K+   +D     E    + E +A  A AT   AS    +    L    K+  +A   +
Sbjct: 72  QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
           A K       + +     G T A        +      A  T   E + EG      AA 
Sbjct: 132 AGK-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186

Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
                   K G      A  +S D S SS   D   K   K   V       AA+ PA  
Sbjct: 187 --------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKG 232

Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
                AT  PP + G +  ++      +E     S    + +EE P A
Sbjct: 233 TPGKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)

Query: 10  QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
           + EK  D+ +  ++     D  +A  A T  QA     I + K   +K +   +A+    
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579

Query: 68  KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
               APV  G +   K G  T+ A ++PA      +P E   + E    E++  G A T 
Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635

Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
             A       + KA S                           AE +  +++S + S S 
Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
           +A  +PA+ +       A    AAA  P+A+           AAA+A  + P++      
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755

Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
                     G +S            + +    +D G  EE    +E A
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804



 Score = 31.6 bits (70), Expect = 0.63
 Identities = 30/153 (19%), Positives = 62/153 (40%), Gaps = 20/153 (13%)

Query: 66   ANKKDEAPVADGVEKKGEGTTTAEAAPAT-----GSKPDEPGKAGETPSEEKKGEGDAAT 120
            ++ K+ + ++DG +++G  T  ++  PA+      +      KA E      + +  +  
Sbjct: 964  SSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGV 1023

Query: 121  EQAAPQAPASSEE-------------KAGSAETESATKA--STDNSPSSKAEDAPAKEEP 165
            + A    PA+S +             K    E + ATKA  S+D+S  S    + ++E+ 
Sbjct: 1024 DSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDG 1083

Query: 166  KQADVPAAVTAAAATTPAAEDAAAKATAQPPTE 198
            +      +       TP+  +   + TA   +E
Sbjct: 1084 EGPQGAKSAHTLVGPTPSRTETLVEETAAESSE 1116



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)

Query: 55   KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
            K D   +  +    KD+    DG ++          +P TG K    G   +   + KKG
Sbjct: 1148 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1204

Query: 115  EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
             G+      A Q+                   +S  K  +   E   K   D +  S  +
Sbjct: 1205 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1264

Query: 158  DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
               +++     D PAA T  +       A E   A  + +  + T +     +      +
Sbjct: 1265 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1324

Query: 215  TKPKESARQDEGKEEEPEAD 234
             K  + +   +G ++EPE +
Sbjct: 1325 EKKGKGSLGSQGAKDEPEEE 1344


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 64.3 bits (155), Expect = 9e-11
 Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%)

Query: 59  VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 108
           V A +A+++ +D +  +D   VE K           +  A+  P  G+ P  PGKAG   
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163
           S+ K G+ +  +E       +SSEE + S E   A KA      S K     A  APAKE
Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303

Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
            P++   PA       T PA   A A    +    + E S +EE  EA  + KP   A Q
Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 33  KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87
           K AT       G +  +   G+ ++D +++  E++  ++E P A  + + K  G T+   
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295

Query: 88  -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
                A+ +P  G+ P  PGK G   ++ + G+ +  ++        SS E++ S E   
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347

Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202
           A    +  +P  +A  APAKE P++   PA          AA+    K      + + ES
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405

Query: 203 SQAEENIEAVDETKPKESARQDEGK 227
               E + A++  + K   +  + K
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)

Query: 35   ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94
            +T +QA     + + KL  E +   +A E+  + +D +  + G E+ GEG   A++A   
Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095

Query: 95   GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
            G  P       ET  EE       A E +     A S+       T   T A   NS +S
Sbjct: 1096 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1142

Query: 155  KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
            KA        PK    P+     ++T  A +D   K  A+P    G  S      EA   
Sbjct: 1143 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1191

Query: 215  TKPKESARQDEG 226
            T P++S +  +G
Sbjct: 1192 TTPQKSRKPKKG 1203



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)

Query: 52  KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
           K E+  +  + E+  +   E P A    ++       +A P +      P KAG    + 
Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166
           K  +    +E +   + ++  E+A +A T +  K +     T   P      A AK  P 
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582

Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
           +    A   A  AT+PA    A     Q P E   SS+  ++ E
Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)

Query: 27  PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86
           P  K   AA ++Q   +   +R     E+ D  + A A  N     P+    + K   +T
Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434

Query: 87  TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133
                   G+ P  PGK G           E  SE    E   +++   P A A ++E  
Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494

Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
                              KAG    +   +   DNS SS+     A  E    + PAA+
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550

Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215
           TAA A                 TT +A+ A  +   Q P + G ++    +  AV     
Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610

Query: 216 KPKESARQDEGKEEEPE 232
           +P E +   E  + E E
Sbjct: 611 RPAEDSSSSEESDSEEE 627



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)

Query: 26  KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77
           K + KA+ AA +  +     S  G +     + +++   +      N ++   +A G   
Sbjct: 710 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 769

Query: 78  VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130
           V   G+   TA  A  TG + D      E+ SEE+       K  G     +AA  APA 
Sbjct: 770 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 827

Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177
              + G+A T    K     + + K +D+ +  E   +D   PAAVT+A           
Sbjct: 828 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886

Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211
                   A TPA   AA+   KA A   T    SS++E+                N+  
Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946

Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235
           +    P              KES+R  +GK++E  A Q
Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 984



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%)

Query: 72  APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 131
           A    G+   G+  +++E   ++  + D   KA E   + +     A         PA  
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243

Query: 132 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 185
            +    A    A K   D+  SS+      E+ PA +   QA      +   AA+ PA E
Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303

Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
                A   PP +TG    A    +A    +  +S+ ++   EEE  A
Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 52/228 (22%), Positives = 74/228 (32%), Gaps = 21/228 (9%)

Query: 7   RTKQVEKNDDDQKIEQDGIKPEDKAHKA-ATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           + K+   +D     E    + E +A  A AT   AS    +    L    K+  +A   +
Sbjct: 72  QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
           A K       + +     G T A        +      A  T   E + EG      AA 
Sbjct: 132 AGK-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186

Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
                   K G      A  +S D S SS   D   K   K   V       AA+ PA  
Sbjct: 187 --------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKG 232

Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
                AT  PP + G +  ++      +E     S    + +EE P A
Sbjct: 233 TPGKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)

Query: 10  QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
           + EK  D+ +  ++     D  +A  A T  QA     I + K   +K +   +A+    
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579

Query: 68  KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121
               APV  G +   K G  T+ A ++PA      +P E   + E    E++  G A T 
Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635

Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154
             A       + KA S                           AE +  +++S + S S 
Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199
           +A  +PA+ +       A    AAA  P+A+           AAA+A  + P++      
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755

Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
                     G +S            + +    +D G  EE    +E A
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804



 Score = 32.7 bits (73), Expect = 0.28
 Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%)

Query: 66   ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125
            ++ K+ + ++DG +++G  T  ++  PA+             P  +   +  A     A 
Sbjct: 964  SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1011

Query: 126  QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
               A ++  +G         A++  S S +A+      +PK  +V  A T A  ++  +E
Sbjct: 1012 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1070

Query: 186  DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
            D++  ++     E GE  Q  ++   +  T  +     +E   E  E D
Sbjct: 1071 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1117



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)

Query: 55   KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
            K D   +  +    KD+    DG ++          +P TG K    G   +   + KKG
Sbjct: 1147 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1203

Query: 115  EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157
             G+      A Q+                   +S  K  +   E   K   D +  S  +
Sbjct: 1204 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1263

Query: 158  DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
               +++     D PAA T  +       A E   A  + +  + T +     +      +
Sbjct: 1264 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1323

Query: 215  TKPKESARQDEGKEEEPEAD 234
             K  + +   +G ++EPE +
Sbjct: 1324 EKKGKGSLGSQGAKDEPEEE 1343


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 63.5 bits (153), Expect = 1e-10
 Identities = 65/244 (26%), Positives = 115/244 (47%), Gaps = 32/244 (13%)

Query: 10   QVEKNDDDQKIEQDGIKPEDKAH-KAATKIQASFRGHITRKKLKGE---KKDDVQAAEAE 65
            ++++ +++ + E DG++ + K+  + A +++         +K +G+   + D V+A EAE
Sbjct: 2008 EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE------TQKTEGDAQPESDGVEAPEAE 2061

Query: 66   ANKKDEAPVADGVEKKGEGTTTAE-----AAPATG-SKPDEPG-KAGETPSEEKKGEGDA 118
                +EA  A+G  ++ EG    E     A  A G ++P+  G +A E   E +K EG  
Sbjct: 2062 ----EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117

Query: 119  ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA--AVTA 176
            A E      P S   +A  AE E+  +     S   +A+DA  + +P+   + A  A   
Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQPE-----SEGVEAQDAEGEAQPESEGIEAQEAEEE 2172

Query: 177  AAATTPAAEDAAAKATAQPPTETGESSQAE----ENIEAVDETKPKESARQDEGKEEEPE 232
            A       E   A+  AQP +E  E+ +AE      +E V+  + +E A+ +    E PE
Sbjct: 2173 AQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPE 2232

Query: 233  ADQE 236
            A+ E
Sbjct: 2233 AEGE 2236



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 64/244 (26%), Positives = 102/244 (41%), Gaps = 42/244 (17%)

Query: 10   QVEKNDDDQKIEQDGIKP---EDKAHKAATKIQASFRGHITRKKLKGEKKD-DVQAAEAE 65
            + +K + D + E DG++    E++A +A  ++Q +        +   E +D D Q AE E
Sbjct: 2040 ETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA------EGEAHPESEDVDAQEAEGE 2093

Query: 66   ANKKDE---APVADGVEKKGEGT----TTAEAAPATGS--KPDEPGKA------------ 104
            A  + E   AP A+G  +K EG     T  EA P +     P+  G+A            
Sbjct: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153

Query: 105  -GETPSEEKKGEGDAATEQAAPQ-----APASSEEKAGSAETESATKASTDNSPSSKAED 158
             GE   E +  E   A E+A P+     AP +  E    +E   A +A  +  P  +  +
Sbjct: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213

Query: 159  AP-----AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVD 213
            AP     A+ EP+  + P A   A   +        K + Q     G+S +A E+   V 
Sbjct: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273

Query: 214  ETKP 217
            E +P
Sbjct: 2274 EDRP 2277



 Score = 58.5 bits (140), Expect = 5e-09
 Identities = 61/204 (29%), Positives = 95/204 (46%), Gaps = 28/204 (13%)

Query: 60   QAAEAEANKKDEAPVADGVEKKGE--GTTTAEAAPATG-SKPDEPG-KAGETPSEEKKGE 115
            Q +  E N + EA  A G +  G+  G    EA  A G ++P+  G +A E   + ++ E
Sbjct: 1806 QGSGHEDNLQGEA-AAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE 1864

Query: 116  GDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE---EPKQADVPA 172
            G+A  E    +AP +  E    +E     +A  +  P S+  +AP  E   +P+   V A
Sbjct: 1865 GEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA 1924

Query: 173  AVT-------AAAATTPAAEDAA--AKATAQPPTETGESSQAE-------ENIEAVD--- 213
              T       +  A    AE+AA  A+   QP +E  ES +AE       E++EA++   
Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV 1984

Query: 214  ETKPKESARQDEGKE-EEPEADQE 236
            ET+  E   Q E ++ E PEA+ E
Sbjct: 1985 ETQEAEGEAQPESEDVEAPEAEGE 2008



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 54/195 (27%), Positives = 81/195 (41%), Gaps = 20/195 (10%)

Query: 61   AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE-------EKK 113
            A EAE   + E+ V +  E + E    +E   A   + +     GE   E       E +
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006

Query: 114  GEGDAATEQAAPQA------PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 167
            GE   A E+A P++      P S  E+A   E E+  K   D  P S   +AP  EE  Q
Sbjct: 2007 GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQ-KTEGDAQPESDGVEAPEAEEEAQ 2065

Query: 168  ADVPAAVTAAAATTPAAEDA---AAKATAQPPTETGESSQAE---ENIEAVDETKPKESA 221
                    A     P +ED     A+  AQP +E  E+ +AE   +  E ++  + +  A
Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125

Query: 222  RQDEGKEEEPEADQE 236
            + +    E PEA+ E
Sbjct: 2126 QPESEGIEAPEAEGE 2140



 Score = 57.0 bits (136), Expect = 1e-08
 Identities = 55/196 (28%), Positives = 89/196 (45%), Gaps = 27/196 (13%)

Query: 54   EKKDDVQAAEAEANKKDE---APVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPS 109
            E + D Q AE EA  + E   AP A+G  + + E   T EA      +P+  G   E P 
Sbjct: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEV--QPESEG--AEAPE 1910

Query: 110  EEKKGEGDA----ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK---AEDAPAK 162
             EK+ + +     A E      P S   +A  AE E+A +A     P S+   +++A  +
Sbjct: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAE-EAAQEAEGQTQPESEVIESQEAEEE 1969

Query: 163  EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
             +P+  DV A            E   A+  AQP +E  E+ +AE  ++  +E    E+  
Sbjct: 1970 AQPESEDVEALEVEV-------ETQEAEGEAQPESEDVEAPEAEGEMQEAEE----EAQP 2018

Query: 223  QDEGKEEEPEADQEHA 238
            + +G E +P+++ E A
Sbjct: 2019 ESDGVEAQPKSEGEEA 2034



 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 52/201 (25%), Positives = 86/201 (42%), Gaps = 21/201 (10%)

Query: 53   GEKKDDVQAAEAEANKKDEAPVADG----VEKKGEGTTTAEAAPATGSKPDE--PGKAG- 105
            GE + D  A E E    +    A       E++GEG +        GS  ++   G+A  
Sbjct: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAA 1820

Query: 106  ---ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-- 160
               + P +    EG  A E      P S   +A  AE + A +A  +  P S+  +AP  
Sbjct: 1821 GGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD-AQEAEGEAQPESEDVEAPEA 1879

Query: 161  ---AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVD 213
               A+ E +  + P A       +  AE   A+  AQP TE+ E+     + E   E  +
Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE 1939

Query: 214  ETKPKESARQDEGKEEEPEAD 234
              + +E+A++ EG + +PE++
Sbjct: 1940 AQEAEEAAQEAEG-QTQPESE 1959



 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 45/182 (24%), Positives = 84/182 (46%), Gaps = 8/182 (4%)

Query: 55   KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
            + +  +A EAE   + E    + +E +GE    +E A A  ++       G+T  E +  
Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVI 1961

Query: 115  EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-AKEEPKQADVPAA 173
            E   A E+A P+   S + +A   E E+  +A  +  P S+  +AP A+ E ++A+  A 
Sbjct: 1962 ESQEAEEEAQPE---SEDVEALEVEVET-QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ 2017

Query: 174  VTA-AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232
              +      P +E   A+       +T   +Q E   + V+  + +E A++ EG+ +E E
Sbjct: 2018 PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES--DGVEAPEAEEEAQEAEGEVQEAE 2075

Query: 233  AD 234
             +
Sbjct: 2076 GE 2077



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 53/201 (26%), Positives = 89/201 (44%), Gaps = 19/201 (9%)

Query: 55   KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114
            + +DV+A EAE   + E+   +  E + E    +E A A  ++ +   +     + E +G
Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEG 1929

Query: 115  EGDAATEQA-APQAPASSEEKAGSAETESATKAS--TDNSPSSKAEDAPAKE---EPKQA 168
            E +  +E A A +A  +++E  G  + ES    S   +     ++ED  A E   E ++A
Sbjct: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEA 1989

Query: 169  DVPAAVTAAAATTPAAEDAAAKAT--AQPPTETGES---SQAEENIEAVDETKPKESARQ 223
            +  A   +     P AE    +A   AQP ++  E+   S+ EE  E   ET+  E   Q
Sbjct: 1990 EGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQ 2049

Query: 224  DEG--------KEEEPEADQE 236
             E         +EE  EA+ E
Sbjct: 2050 PESDGVEAPEAEEEAQEAEGE 2070



 Score = 33.9 bits (76), Expect = 0.13
 Identities = 41/203 (20%), Positives = 79/203 (38%), Gaps = 37/203 (18%)

Query: 10   QVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK- 68
            Q+E+   ++ ++++G++ E+                      +G+++++ Q  E E    
Sbjct: 1321 QLEETKTEEGLQEEGVQLEETKETEG----------------EGQQEEEAQLEEIEETGG 1364

Query: 69   ---KDEAPVADGVEKKGEGTTTAEAA---------PATGSKPDEPGKAGETPSEEKKGEG 116
               ++E    + V++  EG    EA          P  GS   +      +P  +   E 
Sbjct: 1365 EGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQED 1424

Query: 117  DAATEQAAPQAPASSEE--KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
            D   E+ A +A AS+E     G+ E        ++  PS+    + ++ EP     P A 
Sbjct: 1425 DPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484

Query: 175  ------TAAAATTPAAEDAAAKA 191
                  T A  T  AAE +++ A
Sbjct: 1485 MMGQEHTQAQPTQGAAERSSSVA 1507



 Score = 30.8 bits (68), Expect = 1.1
 Identities = 25/120 (20%), Positives = 50/120 (41%), Gaps = 9/120 (7%)

Query: 83  EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142
           +G  +A  +   G++    G  GE P     G G    EQ     P +  E+  S+++ +
Sbjct: 478 DGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSA 537

Query: 143 ATKASTDNSP--------SSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 194
           +T +   +S           KA    +++E  +   PA+  A + ++  ++D  A+   Q
Sbjct: 538 STGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPAS-PALSLSSLRSDDLQAETQGQ 596



 Score = 29.6 bits (65), Expect = 2.4
 Identities = 41/210 (19%), Positives = 74/210 (35%), Gaps = 21/210 (10%)

Query: 8   TKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQAS------FRGHITRKKLKGEKKDDVQA 61
           TKQV +  + ++  QDG  P      ++T+ QAS        G +  + L G     V  
Sbjct: 683 TKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTP 742

Query: 62  AEAEANKKDEAP-VADGVEKKGE-GTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119
           A         +P  A      G+ G+ T   AP      D   K+G     E+  +    
Sbjct: 743 AVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQP 802

Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE-----------EPKQA 168
           +     Q     +   G   +   ++  T   P+ +A+  P+ E            P+  
Sbjct: 803 SSPLVLQVGRPEQGAVGPHRSHCCSQPGT--QPAQEAQRGPSPEASWLCGRYCPTPPRGR 860

Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTE 198
             P   +++  +T ++  + A+     P E
Sbjct: 861 PCPQRRSSSCGSTGSSHQSTARGPGGSPQE 890



 Score = 29.3 bits (64), Expect = 3.1
 Identities = 42/195 (21%), Positives = 66/195 (33%), Gaps = 22/195 (11%)

Query: 56   KDDVQAAEAEANKKDEAPVAD-GVEKKGEGT---TTAEAAPATGSKPDEPGKAGETPSEE 111
            KD  +  E  +  KD  P  D G ++   G    T ++A P  GS          + S  
Sbjct: 1142 KDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGV 1201

Query: 112  KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 171
                G   + +++   P + +    +  TE   K S     S   E     E  +Q   P
Sbjct: 1202 DISSGSGGSGESS--VPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFP 1259

Query: 172  AAVTAAAATTPAAEDAA----------------AKATAQPPTETGESSQAEENIEAVDET 215
              + A A      ED A                A+ T Q   +  E+ +  E     +E 
Sbjct: 1260 TFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEA 1319

Query: 216  KPKESARQDEGKEEE 230
               E  + +EG +EE
Sbjct: 1320 VQLEETKTEEGLQEE 1334


>gi|153070260 myristoylated alanine-rich protein kinase C substrate
           [Homo sapiens]
          Length = 332

 Score = 61.6 bits (148), Expect = 6e-10
 Identities = 49/196 (25%), Positives = 84/196 (42%), Gaps = 24/196 (12%)

Query: 30  KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD-------EAPVADGVEKKG 82
           KA   AT   ++      +K+   +K   +     + NKK+       EAP A+G + + 
Sbjct: 137 KAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEA 196

Query: 83  EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA--------PASSEEK 134
            G   A AA A  +  ++    GE  +  ++G      ++A PQ         PAS E K
Sbjct: 197 AGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETK 256

Query: 135 AGSAET--------ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED 186
           A    +        E+   A+   +PS+    AP ++E   A+ PAA  A++A    +++
Sbjct: 257 AAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEEPAAAAASSACAAPSQE 316

Query: 187 AAAKATAQ-PPTETGE 201
           A  + + + PP E  E
Sbjct: 317 AQPECSPEAPPAEAAE 332



 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 64/222 (28%), Positives = 87/222 (39%), Gaps = 61/222 (27%)

Query: 70  DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
           D +P A     K E      A  A   +P   G    +PS  +KGE  AA   AAP+A A
Sbjct: 44  DASPAAAESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAA---AAPEAGA 100

Query: 130 SSEEKAG-------------SAETESATKASTDNSPSSKAED----APAKEEPK------ 166
           S  EK               +AE E+A+ AS+ +SP  KAED    +P+ E PK      
Sbjct: 101 SPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSP--KAEDGATPSPSNETPKKKKKRF 158

Query: 167 ------------------------QADVPAAV----TAAAATTPAAEDAAAKATAQPPTE 198
                                   +A+ PAA      AA     AA +A A +  Q    
Sbjct: 159 SFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAP 218

Query: 199 TGESSQAEENIEAVD--ETKPKESARQDEGKEEEPEADQEHA 238
             E++  EE     D  E KP+E+A      E+ P +D+  A
Sbjct: 219 GEEAAAGEEGAAGGDPQEAKPQEAA---VAPEKPPASDETKA 257



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 66/253 (26%), Positives = 89/253 (35%), Gaps = 41/253 (16%)

Query: 22  QDGIKPEDKAH---KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK---KDEAPVA 75
           + G K E +A+    AA K + +  G         EK +   AA  EA     + EAP  
Sbjct: 51  ESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAE 110

Query: 76  DGVEKKGEGTTT----AEAAPATGSKPDE----PGKAGETPSEEKKG------------- 114
               + G  T      A AA +T S   E    P  + ETP ++KK              
Sbjct: 111 GEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFS 170

Query: 115 ------EGDAATEQAAPQAPASSEEKAGSAETESATK-ASTDNSPSSKAEDAPAKEEPKQ 167
                 E     E  AP A    +E AG A   +A   A++    ++  E+A A EE   
Sbjct: 171 FKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAA 230

Query: 168 ADVPA-AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE------NIEAVDETKPKES 220
              P  A    AA  P    A+ +  A       E  +AEE        EA     P   
Sbjct: 231 GGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAP 290

Query: 221 ARQDEGKEEEPEA 233
             Q+    EEP A
Sbjct: 291 PEQEAAPAEEPAA 303



 Score = 45.1 bits (105), Expect = 6e-05
 Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 27/151 (17%)

Query: 63  EAEANKKDEAPVADGVEK-----KGEGTTTAEAAPA---TGSKPDEPGKAGETPSEEKKG 114
           EA A +  EA VA    K      G      +A+PA   +G+K +E    G  P+ +K+ 
Sbjct: 13  EAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAK-EELQANGSAPAADKEE 71

Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEE------PKQA 168
              A +  A+P A    E  A +A    A       SP  K  +APA+ E      P  A
Sbjct: 72  PAAAGSGAASPSAAEKGEPAAAAAPEAGA-------SPVEK--EAPAEGEAAEPGSPTAA 122

Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTET 199
           +  AA  A++ ++P AED    AT  P  ET
Sbjct: 123 EGEAASAASSTSSPKAEDG---ATPSPSNET 150



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 17/134 (12%)

Query: 81  KGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE----------QAAPQAPAS 130
           KGE    A   P   +    P KA    +   K  GDA+            QA   APA+
Sbjct: 11  KGEA---AAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQANGSAPAA 67

Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED---- 186
            +E+  +A + +A+ ++ +    + A    A   P + + PA   AA   +P A +    
Sbjct: 68  DKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAA 127

Query: 187 AAAKATAQPPTETG 200
           +AA +T+ P  E G
Sbjct: 128 SAASSTSSPKAEDG 141



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 42/139 (30%), Positives = 54/139 (38%), Gaps = 25/139 (17%)

Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAE----------DAPA--K 162
           +G+AA E+    A ASS  KA   E     K + D SP++              APA  K
Sbjct: 11  KGEAAAERPGEAAVASSPSKANGQEN-GHVKVNGDASPAAAESGAKEELQANGSAPAADK 69

Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQP----------PTETGESSQAEENIEAV 212
           EEP  A   AA  +AA     A  AA +A A P            E G  + AE   EA 
Sbjct: 70  EEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEG--EAA 127

Query: 213 DETKPKESARQDEGKEEEP 231
                  S + ++G    P
Sbjct: 128 SAASSTSSPKAEDGATPSP 146


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 61.2 bits (147), Expect = 7e-10
 Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 28/234 (11%)

Query: 9   KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
           K VE+  ++ K+E +  + E+       ++  S         +K EKK+        A +
Sbjct: 451 KFVEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEE 494

Query: 69  KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQA 127
           K+E P A+      E    A+ +P   + P+   + GE   EE + E +   E A + QA
Sbjct: 495 KEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 548

Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTP 182
                EK GS+E E   +   +    ++ E+A AKEE K  +    V       A A   
Sbjct: 549 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 608

Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
             E A +     P  E G+S   +  +E   ++   +S  +++GK   P++  E
Sbjct: 609 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 662



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%)

Query: 13  KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72
           K +  +  E+   +PE +  + A K           K+ +GEK+++    + E  ++DE 
Sbjct: 485 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 542

Query: 73  PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 117
             +D     G EK+G          EG T AEA         E  +A E    E+K E  
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 595

Query: 118 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 177
           A  E+    A     EKA S       K+  +    S    +P +E+ K + VP +    
Sbjct: 596 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 650

Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 235
              +P  +    +    P +++    +A+  +    V+E K K    + E KEEE +  +
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710

Query: 236 E 236
           E
Sbjct: 711 E 711



 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 50/233 (21%), Positives = 87/233 (37%), Gaps = 37/233 (15%)

Query: 6   RRTKQVEKNDDDQKIEQDGI------KPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV 59
           +  K+VE+  ++   +++ +      KPE KA     K     +G     K   E+K   
Sbjct: 583 KEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 641

Query: 60  QAAEAEANKKDEAPVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDA 118
              ++   +K ++PV    VE+KG+   +          P       E  S+ + G+G+ 
Sbjct: 642 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 701

Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178
             E+      A  EEK    E               K +D P K++              
Sbjct: 702 KEEEEKEVKEAPKEEKVEKKE--------------EKPKDVPEKKK-------------- 733

Query: 179 ATTPAAEDAAAK-ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
           A +P  E+A A+  T     +     + +E  + + + K KE A  + G EEE
Sbjct: 734 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 786


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 61.2 bits (147), Expect = 7e-10
 Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 28/234 (11%)

Query: 9   KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
           K VE+  ++ K+E +  + E+       ++  S         +K EKK+        A +
Sbjct: 75  KFVEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEE 118

Query: 69  KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQA 127
           K+E P A+      E    A+ +P   + P+   + GE   EE + E +   E A + QA
Sbjct: 119 KEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 172

Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTP 182
                EK GS+E E   +   +    ++ E+A AKEE K  +    V       A A   
Sbjct: 173 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 232

Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
             E A +     P  E G+S   +  +E   ++   +S  +++GK   P++  E
Sbjct: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 286



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%)

Query: 13  KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72
           K +  +  E+   +PE +  + A K           K+ +GEK+++    + E  ++DE 
Sbjct: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 166

Query: 73  PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 117
             +D     G EK+G          EG T AEA         E  +A E    E+K E  
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 219

Query: 118 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 177
           A  E+    A     EKA S       K+  +    S    +P +E+ K + VP +    
Sbjct: 220 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 274

Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 235
              +P  +    +    P +++    +A+  +    V+E K K    + E KEEE +  +
Sbjct: 275 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 334

Query: 236 E 236
           E
Sbjct: 335 E 335



 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 50/233 (21%), Positives = 87/233 (37%), Gaps = 37/233 (15%)

Query: 6   RRTKQVEKNDDDQKIEQDGI------KPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV 59
           +  K+VE+  ++   +++ +      KPE KA     K     +G     K   E+K   
Sbjct: 207 KEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 265

Query: 60  QAAEAEANKKDEAPVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDA 118
              ++   +K ++PV    VE+KG+   +          P       E  S+ + G+G+ 
Sbjct: 266 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 325

Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178
             E+      A  EEK    E               K +D P K++              
Sbjct: 326 KEEEEKEVKEAPKEEKVEKKE--------------EKPKDVPEKKK-------------- 357

Query: 179 ATTPAAEDAAAK-ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
           A +P  E+A A+  T     +     + +E  + + + K KE A  + G EEE
Sbjct: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 410


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 53/224 (23%), Positives = 95/224 (42%), Gaps = 15/224 (6%)

Query: 22  QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKK 81
           ++ IK  +K+ K    ++         +++  E++ + +  E +  +  E   A+G E++
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEE 500

Query: 82  GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE 141
            +     EAA           +  ++P+E K  E     E+A   A   S EKA S   E
Sbjct: 501 TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE----KEEAKSPAEVKSPEKAKSPAKE 556

Query: 142 SATKASTDNSPSSKAEDAPAK-EEPKQADVPA---------AVTAAAATTPAAEDAAAKA 191
            A       SP  +   +PA+ + P++A  PA         A +   A +P  E+A + A
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616

Query: 192 TAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235
            A+ P +    S AE       ++  KE A+  E K + PE ++
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE-KAKSPEKEE 659



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 57/225 (25%), Positives = 88/225 (39%), Gaps = 17/225 (7%)

Query: 25  IKPEDKA-HKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA-PVADGVEKKG 82
           +K E K   KA + ++   +     K  +  K  DV++ EA+   K+EA   AD   +K 
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785

Query: 83  EGTTTAEA-APATGSKP-DEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAET 140
           +     E  +P     P  E  KA E    +K+       E+  PQ     E    + E 
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845

Query: 141 ESATKASTDNSPSSKAEDAPAKEEPK----QADVPAAVTAAAATTPAAEDAAAKATAQPP 196
           ++     T+    SK E+AP KE PK    +   PA      +   A ++ A      P 
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905

Query: 197 TETGESSQAEENIEAVDETKPKESA-----RQDEGKEEEPEADQE 236
            E     +A   +E  ++ KPKE         D+ K +EP    E
Sbjct: 906 PE----KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946



 Score = 55.5 bits (132), Expect = 4e-08
 Identities = 56/240 (23%), Positives = 108/240 (45%), Gaps = 15/240 (6%)

Query: 7   RTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEA 66
           + K  EK    +K E++ +  E++  +     + +       K+ +G++++  +  EAE 
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496

Query: 67  NKKDE----APVADGVEKKGEGTTTAEA-APATGSKPD--EPGKAGETPSEEKKGEGDAA 119
            +++     A  A   EK+ +     EA +PA    P+  E     E  S EK       
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556

Query: 120 TEQAAPQAPASSEEKAGS-AETESATKASTDNSPSSKAEDAPAK-EEPKQADVPA---AV 174
             ++ P+A +  +E+A S AE +S  KA    SP+ +   +PA+ + P++A  P    A 
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAK---SPAKEEAKSPAEAKSPEKAKSPVKEEAK 613

Query: 175 TAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
           + A A +P  E+A + A  + P +    ++ E       ++  KE A+  E  +   +A+
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673



 Score = 55.5 bits (132), Expect = 4e-08
 Identities = 61/257 (23%), Positives = 107/257 (41%), Gaps = 31/257 (12%)

Query: 9   KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEAN 67
           ++ E  +++ K E+ G + E +  +  TK   +       K+ K   K++ ++ AEA++ 
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533

Query: 68  KKDEA--PVADGVEKKGEGTTTAEA-APATGSKPDE-----------PGKAGETPSEEKK 113
           +K+EA  P      +K +     EA +P     P++           P KA     EE K
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593

Query: 114 GEGDAAT---------EQAAPQAPASS---EEKAGSAETESATKASTDNSPSSKAED--- 158
              +A +         E+A   A A S   EE    AE +S  KA +     +K+ +   
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653

Query: 159 APAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK 218
           +P KEE K  +   +   A A +P    +  KA A+ P +     + E       ++  K
Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK 713

Query: 219 ESARQDEGKEEEPEADQ 235
           E A+  E K + P  ++
Sbjct: 714 EEAKSPE-KAKSPVKEE 729



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 53/194 (27%), Positives = 86/194 (44%), Gaps = 16/194 (8%)

Query: 47  TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKP--DEPGKA 104
           T  K+K E+K  V        K ++  V   VE++ E T   E       K   +E GK 
Sbjct: 434 THIKVKSEEKIKV------VEKSEKETVI--VEEQTEETQVTEEVTEEEEKEAKEEEGKE 485

Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-E 163
            E   EE+   G+  T+    +  AS E++A S   E A   +   SP  +   +PA+ +
Sbjct: 486 EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545

Query: 164 EPKQADVPA---AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220
            P++A  PA   A +   A +P  E+A + A  + P +    S A+E  ++  E K  E 
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAKSPEK 603

Query: 221 ARQDEGKEEEPEAD 234
           A+    +E +  A+
Sbjct: 604 AKSPVKEEAKSPAE 617



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 50/222 (22%), Positives = 98/222 (44%), Gaps = 19/222 (8%)

Query: 16  DDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEANKKDEAPV 74
           ++ K   +   PE +  K+  ++++        +K K   K++ ++ AEA++ +K ++PV
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSP-------EKAKSPAKEEAKSPAEAKSPEKAKSPV 608

Query: 75  ADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEK 134
            +  +   E  +  +    + ++   P KA     EE K    A + +   +  A S EK
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE---KEEAKSPEK 665

Query: 135 AGS---AETESATKASTDNSPSSKAED---APAKEEPKQADVPAAVTAAAATTPAAEDAA 188
           A S   AE +S  KA +     +K+ +   +P KEE K  +   +     A +P    + 
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725

Query: 189 AKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
            K  A+ P +    S  +E  ++ ++ K  E A+  + K  E
Sbjct: 726 VKEEAKTPEKA--KSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765



 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 56/232 (24%), Positives = 99/232 (42%), Gaps = 36/232 (15%)

Query: 7   RTKQVEKNDDDQKIEQDGIKPEDK-AHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           +T  V+  +     +++   P DK   KA + ++   +   + +K K   K+D +A E E
Sbjct: 757 KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK---SPEKAKSPLKEDAKAPEKE 813

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQA 123
             KK+E       E+K +     E       K  E  KA  TP  E+K +   + A ++ 
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPP-----KKAEEEKAPATPKTEEKKDSKKEEAPKKE 868

Query: 124 APQAPASSEEKAGSAET--ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATT 181
           AP+ P   E+K  + E   ES  +A  + +   K    P KE P + +V           
Sbjct: 869 APK-PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV----------- 916

Query: 182 PAAEDAAAKATAQPPTETGESSQAEENIEAVDETKP---KESARQDEGKEEE 230
                   K  A+P  +T  + +  ++ +A + +KP   KE+A + +  +EE
Sbjct: 917 --------KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 46/197 (23%), Positives = 76/197 (38%), Gaps = 20/197 (10%)

Query: 54  EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKK 113
           EK++    AE ++ +K ++P  +  +   E  +  +A      +   P +A     EE K
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627

Query: 114 GEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSP------SSKAEDAPAKEE 164
              +  + + A    +  A S EKA S E E A       SP      S +   +P K E
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687

Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR-- 222
            K  +         A +P  E+A +   A+ P +    S  +      +E K  E A+  
Sbjct: 688 AKSPE--------KAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739

Query: 223 -QDEGKEEEPEADQEHA 238
            ++E K  E     E A
Sbjct: 740 VKEEAKSPEKAKSPEKA 756



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 15/228 (6%)

Query: 9   KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEAN 67
           K  EK +     E   +K  +KA   A +   S     + +K K   K++ ++ AEA++ 
Sbjct: 565 KSPEKEEAKSPAE---VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621

Query: 68  KKDEA--PVADGVEKKGEGTTTAEA-APATGSKPD-EPGKAGETPSEEKKGEGDAATEQA 123
            K+EA  P      +K +  T  EA +P     P+ E  K+ E      K E  +  +  
Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681

Query: 124 AP-QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182
           +P +A A S EKA S   E A   S + + S   E+A + E+ K      A T   A +P
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739

Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
             E+A +   A+ P    E ++  +      +T  KE AR    K  E
Sbjct: 740 VKEEAKSPEKAKSP----EKAKTLDVKSPEAKTPAKEEARSPADKFPE 783



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 54/224 (24%), Positives = 92/224 (41%), Gaps = 27/224 (12%)

Query: 9    KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
            K++ K ++ +   ++  KP++   K   K     +   T K    EKKD         +K
Sbjct: 812  KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT--EEKKD---------SK 860

Query: 69   KDEAPVADG----VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124
            K+EAP  +     VE+K E            +K +E     + P+ EK+     A  +  
Sbjct: 861  KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKE-----APAKVE 915

Query: 125  PQAPASSEEKAGSAETE-SATKASTDNSPSSKAEDAPAKEEPKQ--ADVPAAVTAAAATT 181
             +  A  +EK   A+ E    KA   + P+ K E AP K++ K+  A  P       A  
Sbjct: 916  VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975

Query: 182  PAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDE 225
               +   +K  ++P  E  E S + +      ++KP E A +D+
Sbjct: 976  KEDDKTLSKEPSKPKAEKAEKSSSTDQ----KDSKPPEKATEDK 1015



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 49  KKLKGEKKDDVQAAE-AEANKKDEAPVADGVEK--KGEGTTTAEAAPATGSKPDEPGKAG 105
           +K K   K++ ++ E A++ +K+EA   +  +   K E  +  +A     ++   P KA 
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695

Query: 106 ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 165
               EE K    A   ++  +  A S EKA S   E A       SP  +   +P K + 
Sbjct: 696 SPVKEEAKSPEKA---KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKS 752

Query: 166 KQADVPAAVTAAAATTPAAEDA---------AAKATAQPPTETGESSQA--EENIEAVDE 214
            +      V +  A TPA E+A          AK+  +   ++ E +++  +E+ +A ++
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK 812

Query: 215 TKPKESARQDEGKEEE 230
             PK+   +   KEEE
Sbjct: 813 EIPKKEEVKSPVKEEE 828


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 57.8 bits (138), Expect = 8e-09
 Identities = 45/234 (19%), Positives = 96/234 (41%), Gaps = 10/234 (4%)

Query: 9    KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
            ++ ++ ++D K E+ G   +++  +   K      G+  + K + +KK++ + AEA+   
Sbjct: 4784 EEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGG 4843

Query: 69   KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP------SEEKKGEGDAATEQ 122
            + E  + + ++++       +       K  EP +A + P      SE+K G  D   E+
Sbjct: 4844 QGEDKINEQIDERDYDENEVDPYHGNQEKVPEP-EALDLPDDLNLDSEDKNGGEDTDNEE 4902

Query: 123  AAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182
               + P   +EK   A  E+  +  T+   +        +E P + D             
Sbjct: 4903 GEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDD---KAEGEEEMDT 4959

Query: 183  AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
             A+D    A   P   + E  Q+ E  +   + +  E+   D+G + + E ++E
Sbjct: 4960 GADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEERE 5013



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 42/184 (22%), Positives = 71/184 (38%), Gaps = 24/184 (13%)

Query: 53   GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 112
            GE  D+ +  E    +  E P   G E +  G T  E        P EP    E PSE+ 
Sbjct: 4895 GEDTDNEEGEEENPLEIKEKPEEAGHEAEERGET--ETDQNESQSPQEPE---EGPSEDD 4949

Query: 113  KGEGDAATEQAA----------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 162
            K EG+   +  A          P+  +  ++++   + + A +   +N P+ +      +
Sbjct: 4950 KAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEE 5009

Query: 163  EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
            EE + +D    V        A E     +  Q   E  +++QA E   A  E   KE  +
Sbjct: 5010 EEREDSDTEEQV------PEALERKEHASCGQTGVENMQNTQAMELAGAAPE---KEQGK 5060

Query: 223  QDEG 226
            ++ G
Sbjct: 5061 EEHG 5064



 Score = 38.5 bits (88), Expect = 0.005
 Identities = 44/237 (18%), Positives = 91/237 (38%), Gaps = 23/237 (9%)

Query: 7    RTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKG------EKKDDVQ 60
            + K+ ++   +      G +P+++  +  +  +      + RK+         E   + Q
Sbjct: 4986 KDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQ 5045

Query: 61   AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSK-----PDEPGKAGETPSEEKKGE 115
            A E      ++     G E+ G G   A  A    S        +      T S ++K  
Sbjct: 5046 AMELAGAAPEKE---QGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRK-P 5101

Query: 116  GDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT 175
            G A  E++         ++  + +T+S  +      P ++ EDA A E  KQ        
Sbjct: 5102 GQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQ-------- 5153

Query: 176  AAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232
             + A      D A+K   Q   ++G+  + EE  + + +T+ +E  +  + ++ +PE
Sbjct: 5154 GSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPE 5210


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 12/185 (6%)

Query: 65  EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124
           E+ K+++AP  DG+  + +G           S+ +  GK  +  +E KK +G+       
Sbjct: 67  ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE-DAEAELKKEDGEKEETTVG 125

Query: 125 PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ------ADVP---AAVT 175
            Q     +E+  S   E+  K ST  S   KAE+  AK E  Q       D P   A V 
Sbjct: 126 SQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVE 185

Query: 176 AAAATTPAAEDAAAK--ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
              A T + E+   +   + +P  +  +     E+ +AV E + K   ++ +GKEE    
Sbjct: 186 EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHG 245

Query: 234 DQEHA 238
            +E A
Sbjct: 246 AKEEA 250



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 53/219 (24%), Positives = 81/219 (36%), Gaps = 43/219 (19%)

Query: 49  KKLKGEKKDDVQAA-EAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------- 100
           K+ K   +D + A  + EAN  DE  V    E  G+    AE     G K +        
Sbjct: 70  KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129

Query: 101 PGKAGETPSEEKKGEGDAAT--------------------------EQAAPQAPASSEEK 134
            G+  ET SE K+ E   +T                          ++  P+A    E+ 
Sbjct: 130 TGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDA 189

Query: 135 AGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 194
             +++ E+  +      P  KA D  AK E ++A V     A        E+A   A   
Sbjct: 190 KTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK-- 247

Query: 195 PPTETGESSQAEENIEAVDETKP-KESARQDEGKEEEPE 232
                 E + A+E  E  +E +P   S  Q++  E+EPE
Sbjct: 248 ------EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPE 280



 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 46/195 (23%), Positives = 79/195 (40%), Gaps = 21/195 (10%)

Query: 49  KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108
           KK  GEK++    ++    +K+E        ++ E T  +E             KA E  
Sbjct: 113 KKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQ-----------KAEEKE 161

Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAG--SAETESATKASTDNSPSSKAEDAPAKEEPK 166
           ++ + G+   A ++  P+  A+ EE+    +++ E+  +      P  KA D  AK E +
Sbjct: 162 AKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQ 221

Query: 167 QADVPAAVTAAA--------ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK 218
           +A V     A          A   A E+A AK  A+   E    S +EE  + V++    
Sbjct: 222 KAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEG 281

Query: 219 ESARQDEGKEEEPEA 233
            +       EE PE+
Sbjct: 282 GAGVIPSSPEEWPES 296



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 52/220 (23%), Positives = 81/220 (36%), Gaps = 30/220 (13%)

Query: 44  GHITRKKLKGEKKDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSK---- 97
           G +       E ++ ++  E + ++     +P AD  E  G G    E     G      
Sbjct: 4   GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63

Query: 98  -PDEPGKAGETPSE-----EKKGEGDAATE-------QAAPQAPASSEEKAGSAETESAT 144
            P E GK  + P+E     E +GE +   E       +A  +  A +E K    E E  T
Sbjct: 64  PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETT 123

Query: 145 KASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-----PPTET 199
             S + +   +   +  KE  ++    A+    A    A  ++  KA A       P  T
Sbjct: 124 VGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKAT 183

Query: 200 GE------SSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
            E      +SQ E        T+PKE A  +E K E  +A
Sbjct: 184 VEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKA 223



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 56/228 (24%), Positives = 87/228 (38%), Gaps = 21/228 (9%)

Query: 21  EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKD--DVQAAEAEANKKDEAPVADGV 78
           E  G K E K+     + + S    +  +K K E+K+       +A+AN +D+      V
Sbjct: 128 EMTGRKEETKSEPKEAEEKEST---LASEKQKAEEKEAKPESGQKADANDRDKPEPKATV 184

Query: 79  EKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT----EQAAPQAPASSEEK 134
           E++   T + E          EP +  +   EE K E   A      +A P+ P   EE 
Sbjct: 185 EEEDAKTASQEETGQRKECSTEPKE--KATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242

Query: 135 AGSAETESATKASTDN-------SPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187
              A+ E+  K   ++       SPS + E    KE    A V  +       +P  E  
Sbjct: 243 KHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGH 302

Query: 188 AAKATAQPP--TETGESS-QAEENIEAVDETKPKESARQDEGKEEEPE 232
                   P    +G++S  A E+  +     P ES    E KE+ PE
Sbjct: 303 NLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPE 350



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 46/182 (25%), Positives = 69/182 (37%), Gaps = 8/182 (4%)

Query: 8   TKQVEK-NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEA 66
           T+  EK  D++ K E      ED+A     +           K+    K++   A EAE 
Sbjct: 205 TEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEP 264

Query: 67  NKKDEAPVADGVEKKGEGTTTAEAAPATGSK-PDEPGKAGETPSEEKKGEGDAATEQAAP 125
               E    D VEK+ EG   A   P++  + P+ P   G   S +  G    A+ Q +P
Sbjct: 265 GSPSEEQEQD-VEKEPEGG--AGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSP 321

Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT---AAAATTP 182
            A  SS      +  ES +          +   APA+    +A    A+      AA+ P
Sbjct: 322 SASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGP 381

Query: 183 AA 184
            A
Sbjct: 382 TA 383



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 34/124 (27%), Positives = 51/124 (41%), Gaps = 16/124 (12%)

Query: 114 GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAA 173
           GE D + E     A    E+K G    +  T +   ++P      APA+E    A    A
Sbjct: 7   GESDCSAE-----AREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAG--KA 59

Query: 174 VTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEE-EPE 232
           +     T    ++ A       P E G S++ +     +DE K  ES R+  GKE+ E E
Sbjct: 60  INEGPPTESGKQEKA-------PAEDGMSAELQGEANGLDEVK-VESQREAGGKEDAEAE 111

Query: 233 ADQE 236
             +E
Sbjct: 112 LKKE 115


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 55.1 bits (131), Expect = 5e-08
 Identities = 57/236 (24%), Positives = 88/236 (37%), Gaps = 29/236 (12%)

Query: 12  EKNDDDQKIE--QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 69
           + +++DQK +  Q G+KP+ KA KA  K            K K    D   ++E E   K
Sbjct: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPK------------KAKSSDSDSDSSSEDEP-PK 181

Query: 70  DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG-DAATEQAAPQAP 128
           ++ P    V  K +  T A   PA  +     GKA  + S        D + E+ A   P
Sbjct: 182 NQKPKITPVTVKAQ--TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239

Query: 129 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ-----------ADVPAAVTAA 177
             +  K           A+T    SS +ED+ + EE +Q           + VP      
Sbjct: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299

Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
              +   +        Q P E+ E S  E +  + +E KP   A   +   + P A
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 53/233 (22%), Positives = 85/233 (36%), Gaps = 30/233 (12%)

Query: 14  NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK---- 69
           + DD + E+    P+    K     +A  +   T  + K    +D  + E E  KK    
Sbjct: 226 SSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTR-KSSSSEDSSSDEEEEQKKPMKN 284

Query: 70  ------DEAPVADGVEKKGEGTT----TAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119
                    P +    KK  GT       E      S  D   ++  +  EEKK    A 
Sbjct: 285 KPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV 344

Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAA 179
             +A  + P + +    S+++  +  +  D +PS      PA      ++ PA  T + A
Sbjct: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK-----PAGTTKNSSNKPAVTTKSPA 399

Query: 180 TTPAAED----------AAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
             PAA               KA +    E   SS+ E+  + V  TKPK +A+
Sbjct: 400 VKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 58/267 (21%), Positives = 114/267 (42%), Gaps = 46/267 (17%)

Query: 7   RTKQVEKNDDDQKIEQDGIK--PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEA 64
           + K    + +D   E++ ++  P  KA   A ++     G    K  +    ++    + 
Sbjct: 79  KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLP-PGKAAAKASESSSSEESSDDDD 137

Query: 65  EANKKDEAPVADGVEKKGEGTTTAEAAP--ATGSKPDEPGKAGETPSEEKKGEGDAATEQ 122
           E ++K + PV  GV+ + +    A+A P  A  S  D    + + P + +K +    T +
Sbjct: 138 EEDQKKQ-PVQKGVKPQAKA---AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVK 193

Query: 123 AAPQAPAS--------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174
           A  +AP          +  KA S+ + S++ +S+D+S   KA   P K  PK+  V A  
Sbjct: 194 AQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKK-QVVAKA 252

Query: 175 TAAAATTPAAEDAAAKATAQ-------------------------PPTETGESSQAEENI 209
              AATTP  + ++++ ++                          PP +    +Q  +  
Sbjct: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK-- 310

Query: 210 EAVDETKPKESARQDEGKEEEPEADQE 236
           +AV++ +P ES+ +D   E +  +++E
Sbjct: 311 KAVEKQQPVESS-EDSSDESDSSSEEE 336



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 49/228 (21%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 9   KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
           +Q  ++ +D   E D    E+K  K  TK   S +        K   +    ++++++++
Sbjct: 316 QQPVESSEDSSDESDSSSEEEK--KPPTKAVVS-KATTKPPPAKKAAESSSDSSDSDSSE 372

Query: 69  KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAP 128
            DEAP       K  GTT   +     +      K    P +   G     T +A     
Sbjct: 373 DDEAP------SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKA---DS 423

Query: 129 ASSEEKAGSAETESATKASTDNSPSSKAEDA---PAKEEPKQADVPAAVTAAAATTPAAE 185
           +SSEE++ S+E E   K      P + A+ A   PAK+ P+ +   ++ + ++++    E
Sbjct: 424 SSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEE 483

Query: 186 DAAAKATAQPPTE-TGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232
             +  A  + P +  G ++ ++       + +   S+  D+  EEE E
Sbjct: 484 KTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 48/233 (20%), Positives = 91/233 (39%), Gaps = 19/233 (8%)

Query: 13  KNDDDQKIEQDGIKPEDKAHK--AATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 70
           K D     E+     E+K  K  A TK +A+ +  ++           + A +A    +D
Sbjct: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALS-----------LPAKQAPQGSRD 468

Query: 71  EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130
            +  +D    + E   T+++A     +    G A   P+  KKG+ +++   ++  +   
Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEE 528

Query: 131 SEEK---AGSAETES--ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185
            EEK    GS   ++  A   S   + + KA     +EE ++      V+ + +     +
Sbjct: 529 EEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588

Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
           + AAK  A+ P       Q         + + + S+     +EEE E D   A
Sbjct: 589 NEAAK-EAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVA 640



 Score = 37.4 bits (85), Expect = 0.012
 Identities = 36/174 (20%), Positives = 61/174 (35%), Gaps = 7/174 (4%)

Query: 65  EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124
           E   +   PVA   +KK   + + +++         P K    P++        A  +A+
Sbjct: 65  ERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKAS 124

Query: 125 PQAPASSEEKAGSAETESATKASTDNS--PSSKAEDAP---AKEEPKQADVPAAVTAAAA 179
             +  SSEE +   + E   K        P +KA  AP   AK     +D  +       
Sbjct: 125 ESS--SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKN 182

Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233
             P       KA  + P +   ++    N +A   +    S+   +  EEE  A
Sbjct: 183 QKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA 236



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 24/134 (17%), Positives = 53/134 (39%), Gaps = 8/134 (5%)

Query: 103 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 162
           K+ + P  + +  G  A +     + + SE+ +   E      A     P+ +    P K
Sbjct: 59  KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118

Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222
              K ++       ++++  +++D   +   + P + G   QA+       + K  +S  
Sbjct: 119 AAAKASE-------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDS-D 170

Query: 223 QDEGKEEEPEADQE 236
            D   E+EP  +Q+
Sbjct: 171 SDSSSEDEPPKNQK 184


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 60/248 (24%), Positives = 94/248 (37%), Gaps = 20/248 (8%)

Query: 9   KQVEKNDDDQKIEQDG---------IKPEDKAHKAATKIQASFRGHITRKKLKGE--KKD 57
           K+VE++ +D+++ +D          + P+ K  KAA           T+K       KK 
Sbjct: 22  KEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKA 81

Query: 58  DV---QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE--PGKAGETPSEEK 112
            V   + A A   KK   P         +G T  +A  AT  K     P K  +     K
Sbjct: 82  AVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAK 141

Query: 113 KGEGDAATEQAAPQAPASSE-EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 171
           K + D   +  + +     E E     E E A   +   +P+S+ ED    E+ +  D  
Sbjct: 142 KEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDD 201

Query: 172 A---AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKE 228
               +   A  TTPA    AAK          E    EE+ E  D+   ++    D+  +
Sbjct: 202 EEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDD 261

Query: 229 EEPEADQE 236
           EE E ++E
Sbjct: 262 EEEEEEEE 269



 Score = 31.2 bits (69), Expect = 0.82
 Identities = 36/159 (22%), Positives = 55/159 (34%), Gaps = 20/159 (12%)

Query: 49  KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGE----GTTTAEAAPATGSKPDEPG-- 102
           K  K  KK+D    E + +++DE    D  E + E        A AAPA+  + DE    
Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDED 194

Query: 103 --------------KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 148
                         +A ET   + K        +A   A    EE+    E +   +   
Sbjct: 195 DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE 254

Query: 149 DNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187
           D+      E+   +EE    + P       A   AA +A
Sbjct: 255 DDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEA 293


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 44/197 (22%), Positives = 74/197 (37%), Gaps = 15/197 (7%)

Query: 52   KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA----GET 107
            +GE + + +  E E  ++ E    +G E++GEG    E     G   +E G+     GE 
Sbjct: 890  EGEGEGEEEEGEGEGEEEGEG---EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946

Query: 108  PSEEKKGEGDAATEQAA----PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE 163
              EE++GE +   E+       +     EE  G  E E       +     + E+    E
Sbjct: 947  EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006

Query: 164  EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVDETKPKE 219
            E  + +               E+   +   +   E GE      + EEN    +E + +E
Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066

Query: 220  SARQDEGKEEEPEADQE 236
               Q+ G+EE    D E
Sbjct: 1067 GKYQETGEEENERQDGE 1083



 Score = 52.0 bits (123), Expect = 5e-07
 Identities = 52/237 (21%), Positives = 88/237 (37%), Gaps = 24/237 (10%)

Query: 9   KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN- 67
           ++ E+ + + K E +G + E +  K   + +   R     K+ KGE++ D    E E   
Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG---KEEKGEEEGDQGEGEEEETE 802

Query: 68  -----KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQ 122
                K++   V  G  ++G+G    E     G + +  G+  E   EE++GEG    E 
Sbjct: 803 GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG 862

Query: 123 AAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182
              +     EE  G  E E       +       E+    E  ++ +             
Sbjct: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE------------G 910

Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD---EGKEEEPEADQE 236
             E+   +   +   E GE    EE  E   E    E   ++   EG+EEE E + E
Sbjct: 911 EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 55/241 (22%), Positives = 90/241 (37%), Gaps = 22/241 (9%)

Query: 5   MRRTKQVEKN--DDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAA 62
           M R  + EK   + ++  ++DG + E K  +         +GH   +  + E+  + +  
Sbjct: 686 MERPGEGEKELAEKEEWKKRDGEEQEQKERE---------QGHQKERNQEMEEGGEEEHG 736

Query: 63  EAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPG--KAGETPSEEKKG--EGDA 118
           E E  + D     +  EK+GEG    E     G +  E G  K  E   +E+KG  EGD 
Sbjct: 737 EGEEEEGDRE---EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793

Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178
             E    +     EEK    E E             + E+   +EE  + +         
Sbjct: 794 G-EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE 852

Query: 179 ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGK---EEEPEADQ 235
                 E+   +   +   E GE    EE  E   E + +    ++EG+   EEE E + 
Sbjct: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912

Query: 236 E 236
           E
Sbjct: 913 E 913



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 48/240 (20%), Positives = 90/240 (37%), Gaps = 12/240 (5%)

Query: 9    KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
            ++ E+  + ++ E +G + E +  +   + +    G     + +GE+ +     E    +
Sbjct: 827  EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886

Query: 69   KDEAPVADGVEKKGEGTTTAEA-----APATGSKPDEPGKAGETPSEEKKGEG---DAAT 120
             +E    +G E++GEG    E            K +E G+ GE   EE++GEG   D   
Sbjct: 887  GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946

Query: 121  EQAAPQAPASSEEKAGSAETESATKASTD----NSPSSKAEDAPAKEEPKQADVPAAVTA 176
            E    +     EE+ G  E E   +   +         + E    +EE ++         
Sbjct: 947  EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006

Query: 177  AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236
                    E+   +   +   E GE    EE  E   E + KE   ++  +  E E ++E
Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066



 Score = 35.8 bits (81), Expect = 0.033
 Identities = 32/155 (20%), Positives = 60/155 (38%), Gaps = 16/155 (10%)

Query: 21   EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEK 80
            E++G    +       + +  + G     + +GE++ + +  E E   ++E    +G E+
Sbjct: 934  EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993

Query: 81   KGE--------GTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSE 132
            +GE        G    E     G + +E    GE   EE +GEG    E+   +      
Sbjct: 994  EGEEEGEEEGEG---EEEGEGEGEEEEEGEVEGEVEGEEGEGEG----EEEEGEEEGEER 1046

Query: 133  EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 167
            EK G  E E+      +     K ++   +E  +Q
Sbjct: 1047 EKEGEGE-ENRRNREEEEEEEGKYQETGEEENERQ 1080


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 53/195 (27%), Positives = 82/195 (42%), Gaps = 19/195 (9%)

Query: 25  IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEG 84
           +  E  A +A  ++Q+      T ++   E    +Q   A     DE P A+      E 
Sbjct: 495 LSEETSAEEAHAEVQSPLAEETTAEEASAE----IQLLAAIEAPADETP-AEAQSPLSE- 548

Query: 85  TTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESA 143
            T+AE APA    P   G +  E P E +   G+  T          +EE + + +  +A
Sbjct: 549 ETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETT----------AEEASAAIQLLAA 598

Query: 144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKATAQPPTETGES 202
           T+AS + +P+ + +  PA+E P +   P A  A A    P AE+A A+    P  E    
Sbjct: 599 TEASAEEAPA-EVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAE 657

Query: 203 SQAEENIEAVDETKP 217
            Q     EA  E +P
Sbjct: 658 VQPPPAEEAPAEVQP 672



 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 53/192 (27%), Positives = 86/192 (44%), Gaps = 18/192 (9%)

Query: 54  EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPA-------TGSKPDEPGKAGE 106
           E+  ++Q + A     +EAP         E  TTAE A A       T    DE      
Sbjct: 435 EEARELQLSTAMETPAEEAPTEFQSPLPKE--TTAEEASAEIQLLAATEPPADETPAEAR 492

Query: 107 TPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE--SATKASTDNSPSSKAEDAPAKEE 164
           +P  E+    +A  E  +P A  ++ E+A SAE +  +A +A  D +P+     +P  EE
Sbjct: 493 SPLSEETSAEEAHAEVQSPLAEETTAEEA-SAEIQLLAAIEAPADETPAE--AQSPLSEE 549

Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 224
               + PA V + +A   + E+A  +   QPP  +GE + AEE   A+      E++ ++
Sbjct: 550 TSAEEAPAEVQSPSAKGVSIEEAPLE--LQPP--SGEETTAEEASAAIQLLAATEASAEE 605

Query: 225 EGKEEEPEADQE 236
              E +P   +E
Sbjct: 606 APAEVQPPPAEE 617



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 12/226 (5%)

Query: 22  QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV--QAAEAEANKKDEAPVADGVE 79
           Q  +  E  A +A+ +IQ          +   E +  +  + +  EA+ + ++P+A+   
Sbjct: 458 QSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETT 517

Query: 80  KKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAG--- 136
            + E +   +   A  +  DE     ++P  E+    +A  E  +P A   S E+A    
Sbjct: 518 AE-EASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL 576

Query: 137 ---SAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKAT 192
              S E  +A +AS      + A +A A+E P +   P A  A A    P AE+A A+  
Sbjct: 577 QPPSGEETTAEEASAAIQLLA-ATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 635

Query: 193 AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
             P  E     Q     EA  E +P   A +   + + P A++  A
Sbjct: 636 PPPAEEAPAEVQPPPAEEAPAEVQP-PPAEEAPAEVQPPPAEEAPA 680



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 9/133 (6%)

Query: 92  PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNS 151
           PA G+  + P K      EE   +      + AP+      E+A   +  +A +   + +
Sbjct: 400 PAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPR------EEARELQLSTAMETPAEEA 453

Query: 152 PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTET-GESSQAEENIE 210
           P+     +P  +E    +  A +   AAT P A++  A+A +    ET  E + AE    
Sbjct: 454 PTE--FQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSP 511

Query: 211 AVDETKPKESARQ 223
             +ET  +E++ +
Sbjct: 512 LAEETTAEEASAE 524



 Score = 33.5 bits (75), Expect = 0.17
 Identities = 56/250 (22%), Positives = 95/250 (38%), Gaps = 38/250 (15%)

Query: 19  KIEQDGIKPEDKAHKAATKIQAS----FRGHITRKKLKGEKKDDVQAAEAEANKKDEAPV 74
           K ++D +K     HK++ KI AS    F+      +  G+K     +   E  K     +
Sbjct: 176 KSKEDALK-----HKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLL 230

Query: 75  ADGVEKKGEGTTTAE--AAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS-- 130
            D + ++       E  A     S   EP    + P++ +    + AT +A P+ PA   
Sbjct: 231 EDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPR-PAEET 289

Query: 131 ------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA------AA 178
                 S E+   AE  +A   ++       AE+AP  E P +   P+A  +      A 
Sbjct: 290 HVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAE 349

Query: 179 ATTPAAEDAAAK----ATAQPPTETGESSQAEENIEAVDETK--------PKESARQDEG 226
              P+AE++ ++        PP E   S +    I +    K        P E A ++  
Sbjct: 350 ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAP 409

Query: 227 KEEEPEADQE 236
            + EP   +E
Sbjct: 410 AKVEPPTVEE 419


>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
          Length = 437

 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 50/209 (23%), Positives = 81/209 (38%), Gaps = 28/209 (13%)

Query: 56  KDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGE 115
           KD    + AEA   +++P   G E K +  + +++     +  D P K+G      K G 
Sbjct: 134 KDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGS 193

Query: 116 GDAATEQAAP-----------QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-- 162
             +  E   P           Q P     K+G+ E       S   +    ++D+P K  
Sbjct: 194 SKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVV 253

Query: 163 -EEPKQAD--VPAAVTAAAATTPAAE--DAAAKATAQP---PTETGES----SQAEENI- 209
            E+P + D   P +  +     P A+    A K    P    TE+GE     S  +E + 
Sbjct: 254 PEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVK 313

Query: 210 --EAVDETKPKESARQDEGKEEEPEADQE 236
             E  ++ +PKE+   D G EE     +E
Sbjct: 314 SSEPTEDVEPKEAEDDDTGPEEGSPPKEE 342



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 62/262 (23%), Positives = 102/262 (38%), Gaps = 55/262 (20%)

Query: 19  KIEQDGIKPEDKAHKAATKIQASFR-GHITRKKLKGEK-KDDVQAAEAEANKKDEAPVAD 76
           K E+ G++P   A   +T    S R G  T+   + +  KD    + AEA   ++ P   
Sbjct: 27  KQEEAGVRPS--AGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKS 84

Query: 77  GVEKKGE---------------GTT-------------TAEAAPATGSKPDEPGKAG--- 105
           G E K +               G+T             T+++ P   +  D  GK+G   
Sbjct: 85  GAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEA 144

Query: 106 ETPSEEKKGEG-DAATEQAAPQAPASSEEKAGSAETESATKAST--DNSPSSKAEDAPAK 162
           +TP +     G +A T++ +P    S  +       +S     T  D S  S AED   K
Sbjct: 145 QTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPK 204

Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKES 220
           + P +       + A   TP      + A  Q P +    S AEE    ++ ++  P++ 
Sbjct: 205 DVPNK-------SGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQP 257

Query: 221 ARQDEGK--------EEEPEAD 234
           +R+D  K        +E P+AD
Sbjct: 258 SRKDHSKPISNPSDNKELPKAD 279



 Score = 32.3 bits (72), Expect = 0.37
 Identities = 27/145 (18%), Positives = 56/145 (38%), Gaps = 11/145 (7%)

Query: 88  AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS 147
           A A P   ++  +  +AG  PS      G+ +T       P+ S+   GS ++    +  
Sbjct: 15  AGAVPLLATESVKQEEAGVRPSA-----GNVSTH------PSLSQRPGGSTKSHPEPQTP 63

Query: 148 TDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE 207
            D+   S AE    ++ P ++   A     ++    AE    K +        ++++   
Sbjct: 64  KDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDST 123

Query: 208 NIEAVDETKPKESARQDEGKEEEPE 232
           +    +   PK+S  +   + + PE
Sbjct: 124 SKSHPELQTPKDSTGKSGAEAQTPE 148


>gi|117938759 GNAS complex locus XLas [Homo sapiens]
          Length = 1037

 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 61/213 (28%), Positives = 76/213 (35%), Gaps = 15/213 (7%)

Query: 14  NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAP 73
           N D   I  DG  P  K   A  K + + R  +  +  + E   D     AE  K     
Sbjct: 324 NMDSPPIALDG--PPIKVSGAPDKRERAERPPVEEEAAEMEGAADA----AEGGKVPSPG 377

Query: 74  VADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA-PASSE 132
                       T A AAPA  + PD    +G TP +   G   A  +  A  A P S  
Sbjct: 378 YGSPAAGAASADTAARAAPAAPADPD----SGATPEDPDSGTAPADPDSGAFAADPDSGA 433

Query: 133 EKAGSAETESATKASTDNSPSS-KAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAK 190
             A  A+ +S         P S  A DAPA  +P     P A  A AAA T AA  A A 
Sbjct: 434 APAAPADPDSGAAPDAPADPDSGAAPDAPA--DPDAGAAPEAPAAPAAAETRAAHVAPAA 491

Query: 191 ATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
             A  PT    S+     +       P   AR+
Sbjct: 492 PDAGAPTAPAASATRAAQVRRAASAAPASGARR 524



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 46/178 (25%), Positives = 67/178 (37%), Gaps = 27/178 (15%)

Query: 53  GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 112
           G   +D  +  A A+    A  AD           A A P +G+ PD P       + + 
Sbjct: 405 GATPEDPDSGTAPADPDSGAFAAD---PDSGAAPAAPADPDSGAAPDAPADPDSGAAPDA 461

Query: 113 KGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA 172
             + DA     AP APA++E +A               +P + A  APA    + A V  
Sbjct: 462 PADPDAGAAPEAPAAPAAAETRAAHV---------APAAPDAGAPTAPAASATRAAQVRR 512

Query: 173 AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES-ARQDEGKEE 229
           A +AA A+      A  K   +PP+           I+A D   P+ + A    GK E
Sbjct: 513 AASAAPAS-----GARRKIHLRPPS---------PEIQAADPPTPRPTRASAWRGKSE 556



 Score = 37.0 bits (84), Expect = 0.015
 Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 9/139 (6%)

Query: 98  PDEPGKAGETPSEEKKGEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSPSS 154
           PD+  +A   P EE+  E + A + A      +P      AG+A  ++A +A+   +  +
Sbjct: 343 PDKRERAERPPVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAP--AAPA 400

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
             +     E+P     PA   + A        AA  A A P +     + A+ +  A   
Sbjct: 401 DPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAA-- 458

Query: 215 TKPKESARQDEGKEEEPEA 233
             P   A  D G   E  A
Sbjct: 459 --PDAPADPDAGAAPEAPA 475



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 41/156 (26%), Positives = 55/156 (35%), Gaps = 11/156 (7%)

Query: 89  EAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 148
           EAA   G+     G    +P       G A+ + AA  APA+  +    A  E     + 
Sbjct: 357 EAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTA 416

Query: 149 DNSPSSKAEDAPAKEEPKQADVPAAV----TAAAATTPAAEDAAAKATAQPPTETGESSQ 204
              P S A  A    +P     PAA     + AA   PA  D+ A   A    + G + +
Sbjct: 417 PADPDSGAFAA----DPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPE 472

Query: 205 AEENIEAVDETKPKE--SARQDEGKEEEPEADQEHA 238
           A     A  ET+      A  D G    P A    A
Sbjct: 473 APA-APAAAETRAAHVAPAAPDAGAPTAPAASATRA 507


>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
          Length = 3664

 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 55/202 (27%), Positives = 82/202 (40%), Gaps = 21/202 (10%)

Query: 46   ITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAG 105
            +TR + K EK+ D +  E E  +  E              +  +  P+ G          
Sbjct: 1590 LTRMQQK-EKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLE 1648

Query: 106  ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 165
              PS  +K  GD   E     AP  +EEK      E AT  S +  P+S+   AP  E+ 
Sbjct: 1649 SAPSALEKTTGDKTVE-----APLVTEEKT----VEPAT-VSEEAKPASEPAPAPV-EQL 1697

Query: 166  KQADVP--------AAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE-AVDETK 216
            +Q D+P        AA+  A     ++ D      A+PPT     SQAE N++   D T+
Sbjct: 1698 EQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQ 1757

Query: 217  PKESARQDEGKEEEPEADQEHA 238
            P     Q   +  EP+A++  A
Sbjct: 1758 PLSKPAQKSEEANEPKAEKPDA 1779



 Score = 45.1 bits (105), Expect = 6e-05
 Identities = 47/213 (22%), Positives = 84/213 (39%), Gaps = 13/213 (6%)

Query: 28   EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAE-AEANKKDEAPVADGVEKKGEGTT 86
            E +  +AA       RG   + + + +++++ +A E AE  K  E   +   +K      
Sbjct: 1935 ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK------ 1988

Query: 87   TAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKA 146
            TA      G K     K   T  E     G     + +   P ++EE+AGS +      A
Sbjct: 1989 TAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA 2048

Query: 147  STDNSPSSKA-----EDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGE 201
             TD +P   A     E  PA E+  ++    +  +  A   +A      A   P     +
Sbjct: 2049 GTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQ 2108

Query: 202  SSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234
            + + E  + AV   K  ES ++++G   + ++D
Sbjct: 2109 AGERESGVVAVSPEK-SESPQKEDGLSSQLKSD 2140



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 47/210 (22%), Positives = 72/210 (34%), Gaps = 8/210 (3%)

Query: 11   VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 70
            +EK   D+ +E   +  E     A    +A          +  E+ + V         K+
Sbjct: 1654 LEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPV--EQLEQVDLPPGADPDKE 1711

Query: 71   EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130
             A +  GVE+   G    +  P   +KP  PG +          E D+ T+  +  A  S
Sbjct: 1712 AAMMPAGVEEGSSG----DQPPYLDAKPPTPGASFSQAESNVDPEPDS-TQPLSKPAQKS 1766

Query: 131  SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAK 190
             E     AE   AT A  +   + KAE AP  + P   D+      AA      +   +K
Sbjct: 1767 EEANEPKAEKPDAT-ADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSK 1825

Query: 191  ATAQPPTETGESSQAEENIEAVDETKPKES 220
               Q    +          E +D  K K S
Sbjct: 1826 TPVQAAAVSIVEKPVTRKSERIDREKLKRS 1855



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 47/193 (24%), Positives = 72/193 (37%), Gaps = 17/193 (8%)

Query: 49   KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108
            +K KG +K      +   NKK  APV   V +  +    + AA   G+    P    E P
Sbjct: 2327 RKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANE-GTTVQHP----EAP 2381

Query: 109  SEEKKGEGDAATEQAA--------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 160
             EEK+ E   +T   +        P    SS+E   S E  + TKAS         + AP
Sbjct: 2382 QEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEI--SVEERTPTKASVPPDLPPPPQPAP 2439

Query: 161  AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220
              EEP+      ++  +   TP ++ +    T   P+ T            +    P   
Sbjct: 2440 VDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL--PSVTAAKLSPPVASGGIPHQSPPTK 2497

Query: 221  ARQDEGKEEEPEA 233
              +   ++EEP A
Sbjct: 2498 VTEWITRQEEPRA 2510



 Score = 32.0 bits (71), Expect = 0.48
 Identities = 39/178 (21%), Positives = 61/178 (34%), Gaps = 15/178 (8%)

Query: 60   QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119
            + A A+A +++   VA   EK          +    S P +P K  E       G    A
Sbjct: 2103 RGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEA 2162

Query: 120  TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAA 179
            T+ A       + E        SA+ A   ++P   A +    +  K A   +    AAA
Sbjct: 2163 TQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPE----DRDKPAHQASETELAAA 2218

Query: 180  TTPAAEDAAAKAT--AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235
                  D + +      PP   GES           + +P   A+  +  EE  E D+
Sbjct: 2219 IGSIINDISGEPENFPAPPPYPGESQ---------TDLQPPAGAQALQPSEEGMETDE 2267



 Score = 29.6 bits (65), Expect = 2.4
 Identities = 17/42 (40%), Positives = 18/42 (42%)

Query: 152  PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATA 193
            P+SKA   P KE  K  D  AA T   A  P      A A A
Sbjct: 3221 PASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPA 3262



 Score = 28.5 bits (62), Expect = 5.3
 Identities = 17/85 (20%), Positives = 35/85 (41%)

Query: 95  GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154
           G +P+   +   + S       + + ++ A QA   +   +GS     ++ + + +S SS
Sbjct: 230 GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAA 179
            + D+         D PA    +AA
Sbjct: 290 TSSDSSDSSSSSSDDSPARSVQSAA 314


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 9/184 (4%)

Query: 54   EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE---PGKAGETPSE 110
            EK  + +  EA   +K+        E   EG TT E        P+E     K G    E
Sbjct: 865  EKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIE 924

Query: 111  EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADV 170
            + + EG    E +        EEKA + E E   +   ++   S ++ +P ++E      
Sbjct: 925  KFEDEGAGFEESSET---GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAE 981

Query: 171  PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
              A       + A+ D  A+       E GE+ Q+EE     DE    E AR++E + E+
Sbjct: 982  ADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEE---ADEEDKAEDAREEEYEPEK 1038

Query: 231  PEAD 234
             EA+
Sbjct: 1039 MEAE 1042



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 57/241 (23%), Positives = 95/241 (39%), Gaps = 26/241 (10%)

Query: 9   KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
           K+ +   +D+K E++  KP+ +  K   K          ++++K E K +++  E +  K
Sbjct: 640 KETKVKPEDKKEEKE--KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697

Query: 69  KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQA 127
           K+        E K E     E       +  EP K   + P + KK    ++T  +  + 
Sbjct: 698 KEVKKETPPKEVKKE--VKKEEKKEVKKEEKEPKKEIKKLPKDAKK----SSTPLSEAKK 751

Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187
           PA+ + K    E      +     P  K +    K+E K A+  AA     ATT A   A
Sbjct: 752 PAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAA 811

Query: 188 AAKATAQPP----------------TETGESSQAEENIEAVDETKPKESARQDEGKEEEP 231
           A  A   P                 T+  E  +AEE ++   + KP+    +DE K +E 
Sbjct: 812 AGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE-VDVTKDIKPQLELIEDEEKLKET 870

Query: 232 E 232
           E
Sbjct: 871 E 871



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 54/194 (27%), Positives = 84/194 (43%), Gaps = 21/194 (10%)

Query: 57   DDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK---K 113
            DD++  E E    +E+      E+K E T  AE     G +      +  +P+E++   K
Sbjct: 921  DDIEKFEDEGAGFEESSETGDYEEKAE-TEEAEEPEEDGEEHVCVSASKHSPTEDEESAK 979

Query: 114  GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS-----KAEDAPAKE-EPKQ 167
             E DA   +   ++ AS +++A     E+  K   + S        KAEDA  +E EP++
Sbjct: 980  AEADAYIREKR-ESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEK 1038

Query: 168  A---DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAV-DETKPKES--- 220
                D   AV   AA    AE+     T  P  + G  S   E   ++ DET P  S   
Sbjct: 1039 MEAEDYVMAVVDKAAEAGGAEEQYGFLTT-PTKQLGAQSPGREPASSIHDETLPGGSESE 1097

Query: 221  --ARQDEGKEEEPE 232
              A  +E +E++PE
Sbjct: 1098 ATASDEENREDQPE 1111



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 56/253 (22%), Positives = 95/253 (37%), Gaps = 37/253 (14%)

Query: 8   TKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67
           +K V K   ++  E   +   +K  K  +K +   +     K +K E K  V   E  + 
Sbjct: 554 SKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKD---KPIKTETKPSVTEKEVPS- 609

Query: 68  KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 127
           K++ +PV   V +K       +AA     K +   K  +   E++K + + A ++   + 
Sbjct: 610 KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKE--DKT 667

Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAE-----DAPAKE------------------E 164
           P   EEK    E +   K         + +     + P KE                  E
Sbjct: 668 PIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKE 727

Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR-- 222
           PK+        A  ++TP +E A   A  +P     E S  ++++ A    KPKE  +  
Sbjct: 728 PKKEIKKLPKDAKKSSTPLSE-AKKPAALKPKVPKKEESVKKDSVAA---GKPKEKGKIK 783

Query: 223 --QDEGKEEEPEA 233
             + EGK  E  A
Sbjct: 784 VIKKEGKAAEAVA 796



 Score = 33.9 bits (76), Expect = 0.13
 Identities = 37/191 (19%), Positives = 68/191 (35%), Gaps = 33/191 (17%)

Query: 76   DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE--QAAPQAPASSEE 133
            DG    G+ + + E      S P+  G + ET ++  +   D +T   + A +   + + 
Sbjct: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTP-DTSTYCYETAEKITRTPQA 2054

Query: 134  KAGSAETESATKASTDNSPSSKAEDAP-----------------------------AKEE 164
               S ET      +   SPS   +D                               A EE
Sbjct: 2055 STYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEE 2114

Query: 165  P-KQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
            P ++++ P   +  A   P  +    +    PPT   ES+ ++ + +   ET+   S   
Sbjct: 2115 PTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITA 2174

Query: 224  DEGKEEEPEAD 234
            D   + E E++
Sbjct: 2175 DANIDSEDESE 2185



 Score = 32.0 bits (71), Expect = 0.48
 Identities = 31/125 (24%), Positives = 49/125 (39%), Gaps = 8/125 (6%)

Query: 49   KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAA-PATGSKPDEPGKAGET 107
            K LK + K+  +  +     K  +PV     KK +G +   AA P      +   K    
Sbjct: 2233 KALKKDLKEKTKTKKPGTKTKSSSPV-----KKSDGKSKPLAASPKPAGLKESSDKVSRV 2287

Query: 108  PSEEKKGEGD-AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPK 166
             S +KK   + AA     P+  A+  E+    ET++A  AS   S  +        +  K
Sbjct: 2288 ASPKKKESVEKAAKPTTTPEVKAARGEEKDK-ETKNAANASASKSAKTATAGPGTTKTTK 2346

Query: 167  QADVP 171
             + VP
Sbjct: 2347 SSAVP 2351



 Score = 29.3 bits (64), Expect = 3.1
 Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 18/120 (15%)

Query: 25   IKPEDKAHKAATKIQASFRGHITRKKLK---------GEKKDDVQAAEAEANKKDEAPVA 75
            +K + K  K  TK ++S     +  K K         G K+   + +   + KK E+   
Sbjct: 2239 LKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKES--- 2295

Query: 76   DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKA 135
              VEK  + TTT E   A G + D+  K     S  K     A T  A P    +++  A
Sbjct: 2296 --VEKAAKPTTTPEVKAARGEEKDKETKNAANASASK----SAKTATAGPGTTKTTKSSA 2349



 Score = 27.7 bits (60), Expect = 9.1
 Identities = 30/138 (21%), Positives = 48/138 (34%), Gaps = 7/138 (5%)

Query: 102  GKAGETP-----SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKA 156
            G AG TP     ++EK         +  P  P S E      E E A+ +  D       
Sbjct: 1329 GSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSE 1388

Query: 157  EDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETK 216
                    P ++       +A  +  +A+D A+   A+ P E  E S  + + + V    
Sbjct: 1389 SPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFE--EKSGKQGSPDQVSPVS 1446

Query: 217  PKESARQDEGKEEEPEAD 234
               S    + K+E    D
Sbjct: 1447 EMTSTSLYQDKQEGKSTD 1464


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 56/248 (22%), Positives = 96/248 (38%), Gaps = 29/248 (11%)

Query: 6   RRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65
           ++    EK +  +K E   +  E K  K A K +       T+K++KG K++ V+   A+
Sbjct: 182 KKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEK-----TKKEVKGGKQEKVKQTAAK 236

Query: 66  ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPG--------------KAGETPSEE 111
             +  + P      K  E     +AA +   + D+                K G++P+  
Sbjct: 237 VKEVQKTP-----SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA-DV 170
                   TEQA+   PAS   +    E + A K  T  +   + ED   K E + A DV
Sbjct: 292 PP----LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347

Query: 171 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230
                  A+ T       A   A    E  E S+  +    V++ K K+  ++++  E  
Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407

Query: 231 PEADQEHA 238
               +EH+
Sbjct: 408 KSPKKEHS 415



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 51/206 (24%), Positives = 83/206 (40%), Gaps = 42/206 (20%)

Query: 52  KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111
           +GEKK   +   +E  KK++    + ++KK E  T  +       +  EPGKA ET    
Sbjct: 313 EGEKKKAEKKVTSETKKKEK----EDIKKKSEKETAIDV------EKKEPGKASET---- 358

Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAED------APAKEEP 165
           K+G     T + A QA A  +EK    +++   K +    P  K ++       PAK   
Sbjct: 359 KQG-----TVKIAAQAAAKKDEK--KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411

Query: 166 KQADVPAAVTAAAATTPAAEDAAAKA---------------TAQPPTETGESSQAEENIE 210
           K+  VP+     A T  A E+  A +               T +      +S +    ++
Sbjct: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471

Query: 211 AVDETKPKESARQDEGKEEEPEADQE 236
             +  K KE       KE+EPE  ++
Sbjct: 472 DKEPIKGKEEKVPASLKEKEPETKKD 497



 Score = 29.6 bits (65), Expect = 2.4
 Identities = 42/177 (23%), Positives = 70/177 (39%), Gaps = 27/177 (15%)

Query: 17  DQKIEQDG--IKPED------KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68
           D+K+ + G  +KP+       K  K   +I+   +  I+ +K++  K+D V+  +  ++ 
Sbjct: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAIS-EKVQIHKQDIVKPEKTVSHG 555

Query: 69  KDEAPV-----ADGVEKKGEGTTTAEAA---------PATGSKPDEPGKAGETPSEEKKG 114
           K E  V     A  +EK  +   T +A               KP   G +  T S +KK 
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615

Query: 115 EGDAATEQAAPQAPASSEEKAG----SAETESATKASTDNSPSSKAEDAPAKEEPKQ 167
           E      +         EEK      S +  + TKA      S   ED PA ++ K+
Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 49/208 (23%), Positives = 83/208 (39%), Gaps = 35/208 (16%)

Query: 28  EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK--KDEAPVADGVEKKGEGT 85
           ED   K   K +A        ++ + E ++D    + EA K  KDE    DG E K  G 
Sbjct: 106 EDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKN-GN 164

Query: 86  TTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATK 145
              E A     K  E GK GE    + KG G+   E+   +      ++ G  +     K
Sbjct: 165 EKGEDA-----KEKEDGKKGE----DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGK 215

Query: 146 ASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQA 205
              D     + +D   KE+ K+ +               ED              E+ + 
Sbjct: 216 EKGDKK---EGKDVKVKEDEKERE------------DGKEDEGGNEE--------EAGKE 252

Query: 206 EENIEAVDETKPKESARQDEGKEEEPEA 233
           +E+++  +E K ++  ++D+GK+EEP++
Sbjct: 253 KEDLKEEEEGKEEDEIKEDDGKKEEPQS 280


>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
           [Homo sapiens]
          Length = 517

 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 57/254 (22%), Positives = 106/254 (41%), Gaps = 34/254 (13%)

Query: 6   RRTKQVEKNDDDQKIEQDGIKP---------EDKAHKAATKIQASFR--GHITRKKLK-- 52
           RR K  ++++D+++ E+ G +          ED    ++    AS    G + + K K  
Sbjct: 180 RRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAP 239

Query: 53  ----GEKKDDVQAAEAEANKKDEAPVADG--VEKKGEGTTTAEAAPATGSKP-------- 98
               G KK   + ++ EA +  +    +G  V+   +G+++++  P + +K         
Sbjct: 240 LAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPK 299

Query: 99  --DEPGKAGETPSEEKKGEGDAATEQ--AAPQAPASSEEKAGSAETESATKASTDNSPSS 154
             DE   + E   EEK  E D   E+   AP        K  S E++S+ ++  D+  SS
Sbjct: 300 GVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASS 359

Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
               A  K  PK+   P+  ++   + P    A   +T+   T    +S+ E+  + V E
Sbjct: 360 ALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSS--TLRAAASKLEQG-KRVSE 416

Query: 215 TKPKESARQDEGKE 228
               +  R D G +
Sbjct: 417 MPAAKRLRLDTGPQ 430



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 35/196 (17%), Positives = 78/196 (39%), Gaps = 25/196 (12%)

Query: 48  RKKLKGEKKDDVQAAEAEANKKDEAPVA-----DGVEKKGEGTTTA--EAAPATGSKPDE 100
           +++LK + +D+ +  + +  ++  + +      D +E   + +  +  E      +K   
Sbjct: 179 QRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKA 238

Query: 101 PGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 160
           P   G    ++KKG  D A E +        + +    +  S   +S+   P SKA+   
Sbjct: 239 PLAKGGRKKKKKKGSDDEAFEDSD-----DGDFEGQEVDYMSDGSSSSQEEPESKAKAPQ 293

Query: 161 AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220
            +E PK  D  +             D++ ++  + P E  +  + E+      E K ++ 
Sbjct: 294 QEEGPKGVDEQS-------------DSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKD 340

Query: 221 ARQDEGKEEEPEADQE 236
           + ++    EE + D E
Sbjct: 341 SSEESDSSEESDIDSE 356



 Score = 38.9 bits (89), Expect = 0.004
 Identities = 42/177 (23%), Positives = 79/177 (44%), Gaps = 30/177 (16%)

Query: 62  AEAEANKKDEAPVADGVEKKGEGTTTAEAA-PATGSKPDEPGKAGETPSEEKK------- 113
           ++A+A +++E P   GV+++ + +  +E   P    K +E  K   TP E+K+       
Sbjct: 287 SKAKAPQQEEGP--KGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEE 344

Query: 114 ----------GEGDAATEQAAPQAPASSEEK--AGSAETES--ATKASTDNSPSSKAEDA 159
                      E  +A   A  + P   E K   GS+   S   T ++   S SS    A
Sbjct: 345 SDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAA 404

Query: 160 PAKEE--PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214
            +K E   + +++PAA      T P  +  + K+T QPP  +G+++    +++  ++
Sbjct: 405 ASKLEQGKRVSEMPAAKRLRLDTGP--QSLSGKSTPQPP--SGKTTPNSGDVQVTED 457


>gi|7662162 ALEX2 protein [Homo sapiens]
          Length = 632

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%)

Query: 26  KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 82
           KP+++A      + +A  R   T     G        AEAE   +DEA   D  G E   
Sbjct: 40  KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99

Query: 83  EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 123
              ++AEA    GS+  E   AG  P  E                     G  +A     
Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159

Query: 124 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 168
           AP   +AP  +E    +        TE+A        P     +K  +AP    P +A  
Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219

Query: 169 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 211
             VPA  T AAA T AAE                 AA KAT  P   TG   +A     A
Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277

Query: 212 VDETKPKESAR-----QDEGKEEEPEADQ 235
           V +   K   R     + +GK+ + E D+
Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306



 Score = 34.3 bits (77), Expect = 0.097
 Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%)

Query: 85  TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 138
           T  AEA  PAT +    P  A E+P            G +A ++A P A   +  KA SA
Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274

Query: 139 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 193
                +   K  T +    K +   +K E  +  +       AAAA   +A    A    
Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334

Query: 194 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 231
            P +E GES  +  E + ++  ET+ +   R+    ++ P
Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374


>gi|29540562 ALEX2 protein [Homo sapiens]
          Length = 632

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%)

Query: 26  KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 82
           KP+++A      + +A  R   T     G        AEAE   +DEA   D  G E   
Sbjct: 40  KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99

Query: 83  EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 123
              ++AEA    GS+  E   AG  P  E                     G  +A     
Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159

Query: 124 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 168
           AP   +AP  +E    +        TE+A        P     +K  +AP    P +A  
Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219

Query: 169 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 211
             VPA  T AAA T AAE                 AA KAT  P   TG   +A     A
Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277

Query: 212 VDETKPKESAR-----QDEGKEEEPEADQ 235
           V +   K   R     + +GK+ + E D+
Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306



 Score = 34.3 bits (77), Expect = 0.097
 Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%)

Query: 85  TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 138
           T  AEA  PAT +    P  A E+P            G +A ++A P A   +  KA SA
Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274

Query: 139 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 193
                +   K  T +    K +   +K E  +  +       AAAA   +A    A    
Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334

Query: 194 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 231
            P +E GES  +  E + ++  ET+ +   R+    ++ P
Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 56/241 (23%), Positives = 94/241 (39%), Gaps = 28/241 (11%)

Query: 18  QKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEA-EANKKDEA-PVA 75
           QK E+   + E++  K+A   + S +    R+ L    +  + A+ A E + K +A P +
Sbjct: 413 QKKEKKDKERENEKEKSALARERSLK---KRQSLPASPRARLSASTASELSPKSKARPSS 469

Query: 76  DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE----KKGEGDAATEQAAPQAPASS 131
                    +      P     P  P   G T S +    +K E   +   A P+  + S
Sbjct: 470 PSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQS 529

Query: 132 EEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAA------- 184
           + +A S E ESA  AS   SP+     AP ++E   A+ P    AA  T+P A       
Sbjct: 530 KRRA-SNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETP--TDAAVLTSPPAPAPPVTP 586

Query: 185 ---------EDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235
                     + A +  A+   +  E  + EE    +   + K    +   +E E  A++
Sbjct: 587 SKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAER 646

Query: 236 E 236
           E
Sbjct: 647 E 647


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.294    0.113    0.293 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,070,716
Number of Sequences: 37866
Number of extensions: 520723
Number of successful extensions: 9483
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 528
Number of HSP's successfully gapped in prelim test: 1193
Number of HSP's that attempted gapping in prelim test: 4386
Number of HSP's gapped (non-prelim): 4487
length of query: 238
length of database: 18,247,518
effective HSP length: 99
effective length of query: 139
effective length of database: 14,498,784
effective search space: 2015330976
effective search space used: 2015330976
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.8 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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