BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens] (238 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens] 468 e-132 gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens] 446 e-126 gi|30795231 brain abundant, membrane attached signal protein 1 [... 66 2e-11 gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 66 3e-11 gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 66 3e-11 gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 66 3e-11 gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 66 3e-11 gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 64 9e-11 gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 64 9e-11 gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 64 1e-10 gi|153070260 myristoylated alanine-rich protein kinase C substra... 62 6e-10 gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 61 7e-10 gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 61 7e-10 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 60 2e-09 gi|24415404 MDN1, midasin homolog [Homo sapiens] 58 8e-09 gi|157738619 smoothelin-like 1 [Homo sapiens] 56 2e-08 gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 55 5e-08 gi|55956788 nucleolin [Homo sapiens] 54 2e-07 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 53 2e-07 gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 53 2e-07 gi|42518068 trans-golgi network protein 2 [Homo sapiens] 53 3e-07 gi|117938759 GNAS complex locus XLas [Homo sapiens] 52 3e-07 gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 52 6e-07 gi|153945728 microtubule-associated protein 1B [Homo sapiens] 52 6e-07 gi|104526627 triadin [Homo sapiens] 52 6e-07 gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 50 2e-06 gi|156104891 general transcription factor IIF, polypeptide 1, 74... 50 2e-06 gi|7662162 ALEX2 protein [Homo sapiens] 49 4e-06 gi|29540562 ALEX2 protein [Homo sapiens] 49 4e-06 gi|78042577 MAP7 domain containing 1 [Homo sapiens] 49 4e-06 >gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens] Length = 238 Score = 468 bits (1203), Expect = e-132 Identities = 238/238 (100%), Positives = 238/238 (100%) Query: 1 MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ 60 MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ Sbjct: 1 MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ 60 Query: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT 120 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT Sbjct: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT 120 Query: 121 EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT 180 EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT Sbjct: 121 EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT 180 Query: 181 TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA Sbjct: 181 TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 >gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens] Length = 274 Score = 446 bits (1147), Expect = e-126 Identities = 228/229 (99%), Positives = 229/229 (100%) Query: 10 QVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 69 +VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK Sbjct: 46 RVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 105 Query: 70 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA Sbjct: 106 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165 Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA Sbjct: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 225 Query: 190 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA Sbjct: 226 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274 >gi|30795231 brain abundant, membrane attached signal protein 1 [Homo sapiens] Length = 227 Score = 66.2 bits (160), Expect = 2e-11 Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%) Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108 KK KG +D +A E + + A +G K+ E AE A A K ++P + E Sbjct: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 168 +EEK+GE DAA A +AP + EK A A + A E PK A Sbjct: 66 AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123 Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 224 + AA +AA PAA + +K +P ++ A + ++ ++KP S Sbjct: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181 Query: 225 EGKE 228 KE Sbjct: 182 SSKE 185 Score = 60.8 bits (146), Expect = 1e-09 Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%) Query: 13 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72 K DQ E + E + AA K +A K + EK + A+AE K E Sbjct: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106 Query: 73 P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129 A G GE AEAA PA + P AGE PS+E EG+ + AP APA Sbjct: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTE-APAAPA 158 Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189 + E K+ A + S++ +PSSK + PAA T A ++TP A+ AA Sbjct: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204 Query: 190 KATAQPPTE 198 A P E Sbjct: 205 SAEEPKPVE 213 Score = 56.2 bits (134), Expect = 2e-08 Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 35/222 (15%) Query: 14 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAP 73 N +D+K ++ + KA AAT+ + + + E + A AEA + E P Sbjct: 13 NVNDEKAKEK----DKKAEGAATEEEGTPK----------ESEPQAAAEPAEAKEGKEKP 58 Query: 74 VAD----GVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129 D EK+GE A A ++P++ A E +E K EQAAP PA Sbjct: 59 DQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA---PEQEQAAP-GPA 114 Query: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA---------AAAT 180 + E +AE +A S +P++ E + + EPK+ + PAA A A+ + Sbjct: 115 AGGEAPKAAEAAAAPAESA--APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172 Query: 181 TPAAEDAAAKATAQPPTETGESS--QAEENIEAVDETKPKES 220 P + +AA + P SS +A+ + +E KP E+ Sbjct: 173 KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEA 214 Score = 43.1 bits (100), Expect = 2e-04 Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 11/147 (7%) Query: 103 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT----KASTDNSPSSKAED 158 K G ++EK E D E AA + + +E A E A K D KAE+ Sbjct: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68 Query: 159 -------APAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA 211 A AKEE +A+ AA A + + A P GE+ +A E A Sbjct: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAA 128 Query: 212 VDETKPKESARQDEGKEEEPEADQEHA 238 E+ + + +E EP+ + A Sbjct: 129 PAESAAPAAGEEPSKEEGEPKKTEAPA 155 Score = 37.0 bits (84), Expect = 0.015 Identities = 30/84 (35%), Positives = 41/84 (48%), Gaps = 13/84 (15%) Query: 68 KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 127 KK EAP A ++ T ++ APA+ SK PG + PS + E AATE AP + Sbjct: 149 KKTEAPAAPAAQE-----TKSDGAPASDSK---PGSSEAAPSSK---ETPAATE--APSS 195 Query: 128 PASSEEKAGSAETESATKASTDNS 151 ++ A SAE +A NS Sbjct: 196 TPKAQGPAASAEEPKPVEAPAANS 219 >gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e [Homo sapiens] Length = 1451 Score = 65.9 bits (159), Expect = 3e-11 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%) Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104 KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323 Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159 G S+ K G+ + +E +SSEE + S E A KA S K A A Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376 Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219 PAKE P++ PA T PA A A + + E S +EE EA + KP Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431 Query: 220 SARQ 223 A Q Sbjct: 432 KAPQ 435 Score = 57.4 bits (137), Expect = 1e-08 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%) Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87 K AT G + + G+ ++D +++ E++ ++E P A + + K G T+ Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372 Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142 A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424 Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202 A + +P +A APAKE P++ PA AA+ K + + ES Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482 Query: 203 SQAEENIEAVDETKPKESARQDEGK 227 E + A++ + K + + K Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507 Score = 50.8 bits (120), Expect = 1e-06 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%) Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108 V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+ Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163 + K G A P+ + S E+ +E E+ + S K A APAK Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309 Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361 Score = 47.8 bits (112), Expect = 9e-06 Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%) Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94 +T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134 Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154 G TPS + + A E + A S+ T T A NS +S Sbjct: 1135 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1182 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 KA PK P+ ++T A +D K A+P G S EA Sbjct: 1183 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1231 Query: 215 TKPKESARQDEG 226 T P++S + +G Sbjct: 1232 TTPQKSRKPKKG 1243 Score = 47.0 bits (110), Expect = 1e-05 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111 K E+ + + E+ + E P A ++ +A P + P KAG + Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166 K + +E + + ++ E+A +A T + K + T P A AK P Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659 Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210 + A A AT+PA A Q P E SS+ ++ E Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703 Score = 44.3 bits (103), Expect = 9e-05 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%) Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86 P K AA ++Q + +R E+ D + A A N P+ + K +T Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511 Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133 G+ P PGK G E SE E +++ P A A ++E Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571 Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 KAG + + DNS SS+ A E + PAA+ Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627 Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215 TAA A TT +A+ A + Q P + G ++ + AV Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687 Query: 216 KPKESARQDEGKEEEPE 232 +P E + E + E E Sbjct: 688 RPAEDSSSSEESDSEEE 704 Score = 43.1 bits (100), Expect = 2e-04 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%) Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 ++ + D+ +E + +KP KA +TK + + K+ G+ V+ Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 K+ + P + E EG+ + E APA G++ KA E + + A Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179 PA + A A K D+ SS+ E+ PA + QA + AA Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374 Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 + PA E A PP +TG A +A + +S+ ++ EEE A Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425 Score = 42.4 bits (98), Expect = 4e-04 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%) Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77 K + KA+ AA + + S G + + +++ + N ++ +A G Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846 Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130 V G+ TA A TG + D E+ SEE+ K G +AA APA Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177 + G+A T K + + K +D+ + E +D PAAVT+A Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963 Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211 A TPA AA+ KA A T SS++E+ N+ Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023 Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235 + P KES+R +GK++E A Q Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061 Score = 41.6 bits (96), Expect = 6e-04 Identities = 55/256 (21%), Positives = 94/256 (36%), Gaps = 34/256 (13%) Query: 12 EKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKKDDV 59 E++D +++ E +KP K H+ + + G + K+DD Sbjct: 873 EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932 Query: 60 QAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGETPS 109 ++ E++ EAP A + A PA P KA + S Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992 Query: 110 EEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161 + ++ E P ++ +A A KAS + SSK + Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052 Query: 162 -KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETKPKE 219 K+E V +AV AT+P + AK T + + E QA + E+ D++ ++ Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS--ED 1110 Query: 220 SARQDEGKEEEPEADQ 235 S+ G EE+ E Q Sbjct: 1111 SSDSSSGSEEDGEGPQ 1126 Score = 37.7 bits (86), Expect = 0.009 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%) Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67 + EK D+ + ++ D +A A T QA I + K +K + +A+ Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656 Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121 APV G + K G T+ A ++PA +P E + E E++ G A T Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712 Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154 A + KA S AE + +++S + S S Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199 +A +PA+ + A AAA P+A+ AAA+A + P++ Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832 Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 G +S + + +D G EE +E A Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881 Score = 31.2 bits (69), Expect = 0.82 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%) Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161 ++K E DAA + + + +S EE+ AET AT + S D P+ Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121 Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207 KE+ K A T + PA A + +A+P T S+ EE Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175 Score = 30.4 bits (67), Expect = 1.4 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%) Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114 K D + + KD+ DG ++ +P TG K G + + KKG Sbjct: 1187 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1243 Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157 G+ A Q+ +S K + E K D + S + Sbjct: 1244 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1303 Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 +++ D PAA T + A E A + + + T + + + Sbjct: 1304 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1363 Query: 215 TKPKESARQDEGKEEEPEAD 234 K + + +G ++EPE + Sbjct: 1364 EKKGKGSLGSQGAKDEPEEE 1383 >gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d [Homo sapiens] Length = 1488 Score = 65.9 bits (159), Expect = 3e-11 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%) Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104 KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323 Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159 G S+ K G+ + +E +SSEE + S E A KA S K A A Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376 Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219 PAKE P++ PA T PA A A + + E S +EE EA + KP Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431 Query: 220 SARQ 223 A Q Sbjct: 432 KAPQ 435 Score = 57.4 bits (137), Expect = 1e-08 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%) Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87 K AT G + + G+ ++D +++ E++ ++E P A + + K G T+ Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372 Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142 A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424 Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202 A + +P +A APAKE P++ PA AA+ K + + ES Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482 Query: 203 SQAEENIEAVDETKPKESARQDEGK 227 E + A++ + K + + K Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507 Score = 50.8 bits (120), Expect = 1e-06 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%) Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108 V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+ Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163 + K G A P+ + S E+ +E E+ + S K A APAK Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309 Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361 Score = 47.4 bits (111), Expect = 1e-05 Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%) Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94 +T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A Sbjct: 1114 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1172 Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154 G P ET EE A E + A S+ T T A NS +S Sbjct: 1173 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1219 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 KA PK P+ ++T A +D K A+P G S EA Sbjct: 1220 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1268 Query: 215 TKPKESARQDEG 226 T P++S + +G Sbjct: 1269 TTPQKSRKPKKG 1280 Score = 47.0 bits (110), Expect = 1e-05 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111 K E+ + + E+ + E P A ++ +A P + P KAG + Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166 K + +E + + ++ E+A +A T + K + T P A AK P Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659 Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210 + A A AT+PA A Q P E SS+ ++ E Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703 Score = 44.3 bits (103), Expect = 9e-05 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%) Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86 P K AA ++Q + +R E+ D + A A N P+ + K +T Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511 Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133 G+ P PGK G E SE E +++ P A A ++E Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571 Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 KAG + + DNS SS+ A E + PAA+ Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627 Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215 TAA A TT +A+ A + Q P + G ++ + AV Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687 Query: 216 KPKESARQDEGKEEEPE 232 +P E + E + E E Sbjct: 688 RPAEDSSSSEESDSEEE 704 Score = 43.1 bits (100), Expect = 2e-04 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%) Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 ++ + D+ +E + +KP KA +TK + + K+ G+ V+ Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 K+ + P + E EG+ + E APA G++ KA E + + A Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179 PA + A A K D+ SS+ E+ PA + QA + AA Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374 Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 + PA E A PP +TG A +A + +S+ ++ EEE A Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425 Score = 42.4 bits (98), Expect = 4e-04 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%) Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77 K + KA+ AA + + S G + + +++ + N ++ +A G Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846 Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130 V G+ TA A TG + D E+ SEE+ K G +AA APA Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177 + G+A T K + + K +D+ + E +D PAAVT+A Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963 Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211 A TPA AA+ KA A T SS++E+ N+ Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023 Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235 + P KES+R +GK++E A Q Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061 Score = 37.7 bits (86), Expect = 0.009 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%) Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67 + EK D+ + ++ D +A A T QA I + K +K + +A+ Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656 Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121 APV G + K G T+ A ++PA +P E + E E++ G A T Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712 Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154 A + KA S AE + +++S + S S Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199 +A +PA+ + A AAA P+A+ AAA+A + P++ Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832 Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 G +S + + +D G EE +E A Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881 Score = 32.7 bits (73), Expect = 0.28 Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%) Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 ++ K+ + ++DG +++G T ++ PA+ P + + A A Sbjct: 1041 SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1088 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185 A ++ +G A++ S S +A+ +PK +V A T A ++ +E Sbjct: 1089 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1147 Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234 D++ ++ E GE Q ++ + T + +E E E D Sbjct: 1148 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1194 Score = 31.2 bits (69), Expect = 0.82 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%) Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161 ++K E DAA + + + +S EE+ AET AT + S D P+ Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121 Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207 KE+ K A T + PA A + +A+P T S+ EE Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175 Score = 30.4 bits (67), Expect = 1.4 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%) Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114 K D + + KD+ DG ++ +P TG K G + + KKG Sbjct: 1224 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1280 Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157 G+ A Q+ +S K + E K D + S + Sbjct: 1281 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1340 Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 +++ D PAA T + A E A + + + T + + + Sbjct: 1341 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1400 Query: 215 TKPKESARQDEGKEEEPEAD 234 K + + +G ++EPE + Sbjct: 1401 EKKGKGSLGSQGAKDEPEEE 1420 >gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo sapiens] Length = 1450 Score = 65.9 bits (159), Expect = 3e-11 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%) Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104 KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323 Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159 G S+ K G+ + +E +SSEE + S E A KA S K A A Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376 Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219 PAKE P++ PA T PA A A + + E S +EE EA + KP Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431 Query: 220 SARQ 223 A Q Sbjct: 432 KAPQ 435 Score = 57.4 bits (137), Expect = 1e-08 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%) Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87 K AT G + + G+ ++D +++ E++ ++E P A + + K G T+ Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372 Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142 A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424 Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202 A + +P +A APAKE P++ PA AA+ K + + ES Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482 Query: 203 SQAEENIEAVDETKPKESARQDEGK 227 E + A++ + K + + K Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507 Score = 50.8 bits (120), Expect = 1e-06 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%) Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108 V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+ Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163 + K G A P+ + S E+ +E E+ + S K A APAK Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309 Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361 Score = 47.4 bits (111), Expect = 1e-05 Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%) Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94 +T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134 Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154 G P ET EE A E + A S+ T T A NS +S Sbjct: 1135 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1181 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 KA PK P+ ++T A +D K A+P G S EA Sbjct: 1182 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1230 Query: 215 TKPKESARQDEG 226 T P++S + +G Sbjct: 1231 TTPQKSRKPKKG 1242 Score = 47.0 bits (110), Expect = 1e-05 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111 K E+ + + E+ + E P A ++ +A P + P KAG + Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166 K + +E + + ++ E+A +A T + K + T P A AK P Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659 Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210 + A A AT+PA A Q P E SS+ ++ E Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703 Score = 44.3 bits (103), Expect = 9e-05 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%) Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86 P K AA ++Q + +R E+ D + A A N P+ + K +T Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511 Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133 G+ P PGK G E SE E +++ P A A ++E Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571 Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 KAG + + DNS SS+ A E + PAA+ Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627 Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215 TAA A TT +A+ A + Q P + G ++ + AV Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687 Query: 216 KPKESARQDEGKEEEPE 232 +P E + E + E E Sbjct: 688 RPAEDSSSSEESDSEEE 704 Score = 43.1 bits (100), Expect = 2e-04 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%) Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 ++ + D+ +E + +KP KA +TK + + K+ G+ V+ Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 K+ + P + E EG+ + E APA G++ KA E + + A Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179 PA + A A K D+ SS+ E+ PA + QA + AA Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374 Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 + PA E A PP +TG A +A + +S+ ++ EEE A Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425 Score = 42.4 bits (98), Expect = 4e-04 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%) Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77 K + KA+ AA + + S G + + +++ + N ++ +A G Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846 Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130 V G+ TA A TG + D E+ SEE+ K G +AA APA Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177 + G+A T K + + K +D+ + E +D PAAVT+A Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963 Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211 A TPA AA+ KA A T SS++E+ N+ Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023 Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235 + P KES+R +GK++E A Q Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061 Score = 41.6 bits (96), Expect = 6e-04 Identities = 55/256 (21%), Positives = 94/256 (36%), Gaps = 34/256 (13%) Query: 12 EKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKKDDV 59 E++D +++ E +KP K H+ + + G + K+DD Sbjct: 873 EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932 Query: 60 QAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGETPS 109 ++ E++ EAP A + A PA P KA + S Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992 Query: 110 EEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161 + ++ E P ++ +A A KAS + SSK + Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052 Query: 162 -KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETKPKE 219 K+E V +AV AT+P + AK T + + E QA + E+ D++ ++ Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS--ED 1110 Query: 220 SARQDEGKEEEPEADQ 235 S+ G EE+ E Q Sbjct: 1111 SSDSSSGSEEDGEGPQ 1126 Score = 37.7 bits (86), Expect = 0.009 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%) Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67 + EK D+ + ++ D +A A T QA I + K +K + +A+ Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656 Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121 APV G + K G T+ A ++PA +P E + E E++ G A T Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712 Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154 A + KA S AE + +++S + S S Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199 +A +PA+ + A AAA P+A+ AAA+A + P++ Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832 Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 G +S + + +D G EE +E A Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881 Score = 31.2 bits (69), Expect = 0.82 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%) Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161 ++K E DAA + + + +S EE+ AET AT + S D P+ Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121 Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207 KE+ K A T + PA A + +A+P T S+ EE Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175 Score = 30.4 bits (67), Expect = 1.4 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%) Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114 K D + + KD+ DG ++ +P TG K G + + KKG Sbjct: 1186 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1242 Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157 G+ A Q+ +S K + E K D + S + Sbjct: 1243 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1302 Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 +++ D PAA T + A E A + + + T + + + Sbjct: 1303 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1362 Query: 215 TKPKESARQDEGKEEEPEAD 234 K + + +G ++EPE + Sbjct: 1363 EKKGKGSLGSQGAKDEPEEE 1382 >gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo sapiens] Length = 958 Score = 65.9 bits (159), Expect = 3e-11 Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%) Query: 49 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 104 KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323 Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 159 G S+ K G+ + +E +SSEE + S E A KA S K A A Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376 Query: 160 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 219 PAKE P++ PA T PA A A + + E S +EE EA + KP Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431 Query: 220 SARQ 223 A Q Sbjct: 432 KAPQ 435 Score = 57.4 bits (137), Expect = 1e-08 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%) Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87 K AT G + + G+ ++D +++ E++ ++E P A + + K G T+ Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372 Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142 A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424 Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202 A + +P +A APAKE P++ PA AA+ K + + ES Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482 Query: 203 SQAEENIEAVDETKPKESARQDEGK 227 E + A++ + K + + K Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507 Score = 50.8 bits (120), Expect = 1e-06 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%) Query: 59 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 108 V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+ Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163 + K G A P+ + S E+ +E E+ + S K A APAK Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309 Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361 Score = 47.8 bits (112), Expect = 9e-06 Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 27/205 (13%) Query: 47 TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------ 100 T ++K EK++D +++E E++ +EA + K T A+A PA P Sbjct: 750 TVTQVKAEKQEDSESSEEESDS-EEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808 Query: 101 PGKA--------GETPSEEKKGEGDAATEQAAPQAPAS--SEEKAGSAETESATKASTDN 150 PGK +PS+ K + + PAS S KA + ++ T D+ Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868 Query: 151 SPSSKAEDAPAKEEPKQADVPAAVT--AAAATTPAAEDAAAKATAQPPTETGESSQAEEN 208 S + D+ + E P+ T AA PA E A PP +TG S Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS------ 922 Query: 209 IEAVDETKPKESARQDEGKEEEPEA 233 A K +S E + + EA Sbjct: 923 --AAQAGKQDDSGSSSEESDSDGEA 945 Score = 47.0 bits (110), Expect = 1e-05 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111 K E+ + + E+ + E P A ++ +A P + P KAG + Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166 K + +E + + ++ E+A +A T + K + T P A AK P Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659 Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210 + A A AT+PA A Q P E SS+ ++ E Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703 Score = 44.3 bits (103), Expect = 9e-05 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%) Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86 P K AA ++Q + +R E+ D + A A N P+ + K +T Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511 Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133 G+ P PGK G E SE E +++ P A A ++E Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571 Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 KAG + + DNS SS+ A E + PAA+ Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627 Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215 TAA A TT +A+ A + Q P + G ++ + AV Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687 Query: 216 KPKESARQDEGKEEEPE 232 +P E + E + E E Sbjct: 688 RPAEDSSSSEESDSEEE 704 Score = 43.1 bits (100), Expect = 2e-04 Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 16/234 (6%) Query: 8 TKQVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 ++ + D+ +E + +KP KA +TK + + K+ G+ V+ Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV-GDVTPQVKGGALP 258 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 K+ + P + E EG+ + E APA G++ KA E + + A Sbjct: 259 PAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQVRAASAPAKGTPGKG 314 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAA 179 PA + A A K D+ SS+ E+ PA + QA + AA Sbjct: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374 Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 + PA E A PP +TG A +A + +S+ ++ EEE A Sbjct: 375 SAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 425 Score = 37.7 bits (86), Expect = 0.009 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%) Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67 + EK D+ + ++ D +A A T QA I + K +K + +A+ Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656 Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121 APV G + K G T+ A ++PA +P E + E E++ G A T Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712 Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154 A + KA S AE + +++S + S S Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199 +A +PA+ + A AAA P+A+ AAA+A + P++ Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832 Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 G +S + + +D G EE +E A Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881 Score = 36.6 bits (83), Expect = 0.020 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 16/104 (15%) Query: 56 KDDVQAAEAEANKKDEAPVADGVEKKGE------GTTTAEAAPATGSKPDEPGKAGETPS 109 ++D ++E E++ ++EA V+ G+ A+ +P G+ P PGK G PS Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTG--PS 922 Query: 110 EEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPS 153 + G+ D + +SSEE E +A ++ D S Sbjct: 923 AAQAGKQD--------DSGSSSEESDSDGEAPAAVTSAQDQESS 958 Score = 35.8 bits (81), Expect = 0.033 Identities = 43/169 (25%), Positives = 70/169 (41%), Gaps = 20/169 (11%) Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77 K + KA+ AA + + S G + + +++ + N ++ +A G Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846 Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130 V G+ TA A TG + D E+ SEE+ K G +AA APA Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA 177 + G+A T K + + K +D+ + E +D PAAVT+A Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA 952 Score = 31.2 bits (69), Expect = 0.82 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%) Query: 111 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 161 ++K E DAA + + + +S EE+ AET AT + S D P+ Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121 Query: 162 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 207 KE+ K A T + PA A + +A+P T S+ EE Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175 >gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f [Homo sapiens] Length = 1412 Score = 64.3 bits (155), Expect = 9e-11 Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%) Query: 59 VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 108 V A +A+++ +D + +D VE K + A+ P G+ P PGKAG Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163 S+ K G+ + +E +SSEE + S E A KA S K A APAKE Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303 Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 P++ PA T PA A A + + E S +EE EA + KP A Q Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358 Score = 57.4 bits (137), Expect = 1e-08 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%) Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87 K AT G + + G+ ++D +++ E++ ++E P A + + K G T+ Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295 Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142 A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347 Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202 A + +P +A APAKE P++ PA AA+ K + + ES Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405 Query: 203 SQAEENIEAVDETKPKESARQDEGK 227 E + A++ + K + + K Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430 Score = 47.8 bits (112), Expect = 9e-06 Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%) Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94 +T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095 Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154 G TPS + + A E + A S+ T T A NS +S Sbjct: 1096 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1143 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 KA PK P+ ++T A +D K A+P G S EA Sbjct: 1144 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1192 Query: 215 TKPKESARQDEG 226 T P++S + +G Sbjct: 1193 TTPQKSRKPKKG 1204 Score = 47.0 bits (110), Expect = 1e-05 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111 K E+ + + E+ + E P A ++ +A P + P KAG + Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166 K + +E + + ++ E+A +A T + K + T P A AK P Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582 Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210 + A A AT+PA A Q P E SS+ ++ E Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626 Score = 44.3 bits (103), Expect = 9e-05 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%) Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86 P K AA ++Q + +R E+ D + A A N P+ + K +T Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434 Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133 G+ P PGK G E SE E +++ P A A ++E Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494 Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 KAG + + DNS SS+ A E + PAA+ Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550 Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215 TAA A TT +A+ A + Q P + G ++ + AV Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610 Query: 216 KPKESARQDEGKEEEPE 232 +P E + E + E E Sbjct: 611 RPAEDSSSSEESDSEEE 627 Score = 42.4 bits (98), Expect = 4e-04 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%) Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77 K + KA+ AA + + S G + + +++ + N ++ +A G Sbjct: 710 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 769 Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130 V G+ TA A TG + D E+ SEE+ K G +AA APA Sbjct: 770 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 827 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177 + G+A T K + + K +D+ + E +D PAAVT+A Sbjct: 828 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886 Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211 A TPA AA+ KA A T SS++E+ N+ Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946 Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235 + P KES+R +GK++E A Q Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 984 Score = 41.6 bits (96), Expect = 6e-04 Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%) Query: 72 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 131 A G+ G+ +++E ++ + D KA E + + A PA Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243 Query: 132 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 185 + A A K D+ SS+ E+ PA + QA + AA+ PA E Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303 Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 A PP +TG A +A + +S+ ++ EEE A Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348 Score = 39.3 bits (90), Expect = 0.003 Identities = 52/228 (22%), Positives = 74/228 (32%), Gaps = 21/228 (9%) Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKA-ATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 + K+ +D E + E +A A AT AS + L K+ +A + Sbjct: 72 QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 A K + + G T A + A T E + EG AA Sbjct: 132 AGK-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185 K G A +S D S SS D K K V AA+ PA Sbjct: 187 --------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKG 232 Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 AT PP + G + ++ +E S + +EE P A Sbjct: 233 TPGKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279 Score = 37.7 bits (86), Expect = 0.009 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%) Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67 + EK D+ + ++ D +A A T QA I + K +K + +A+ Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579 Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121 APV G + K G T+ A ++PA +P E + E E++ G A T Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635 Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154 A + KA S AE + +++S + S S Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199 +A +PA+ + A AAA P+A+ AAA+A + P++ Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755 Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 G +S + + +D G EE +E A Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804 Score = 31.6 bits (70), Expect = 0.63 Identities = 30/153 (19%), Positives = 62/153 (40%), Gaps = 20/153 (13%) Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPAT-----GSKPDEPGKAGETPSEEKKGEGDAAT 120 ++ K+ + ++DG +++G T ++ PA+ + KA E + + + Sbjct: 964 SSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGV 1023 Query: 121 EQAAPQAPASSEE-------------KAGSAETESATKA--STDNSPSSKAEDAPAKEEP 165 + A PA+S + K E + ATKA S+D+S S + ++E+ Sbjct: 1024 DSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDG 1083 Query: 166 KQADVPAAVTAAAATTPAAEDAAAKATAQPPTE 198 + + TP+ + + TA +E Sbjct: 1084 EGPQGAKSAHTLVGPTPSRTETLVEETAAESSE 1116 Score = 30.4 bits (67), Expect = 1.4 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%) Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114 K D + + KD+ DG ++ +P TG K G + + KKG Sbjct: 1148 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1204 Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157 G+ A Q+ +S K + E K D + S + Sbjct: 1205 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1264 Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 +++ D PAA T + A E A + + + T + + + Sbjct: 1265 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1324 Query: 215 TKPKESARQDEGKEEEPEAD 234 K + + +G ++EPE + Sbjct: 1325 EKKGKGSLGSQGAKDEPEEE 1344 >gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo sapiens] Length = 1411 Score = 64.3 bits (155), Expect = 9e-11 Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%) Query: 59 VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 108 V A +A+++ +D + +D VE K + A+ P G+ P PGKAG Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 163 S+ K G+ + +E +SSEE + S E A KA S K A APAKE Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303 Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 P++ PA T PA A A + + E S +EE EA + KP A Q Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358 Score = 57.4 bits (137), Expect = 1e-08 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%) Query: 33 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 87 K AT G + + G+ ++D +++ E++ ++E P A + + K G T+ Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295 Query: 88 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142 A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347 Query: 143 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 202 A + +P +A APAKE P++ PA AA+ K + + ES Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405 Query: 203 SQAEENIEAVDETKPKESARQDEGK 227 E + A++ + K + + K Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430 Score = 47.4 bits (111), Expect = 1e-05 Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%) Query: 35 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 94 +T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095 Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154 G P ET EE A E + A S+ T T A NS +S Sbjct: 1096 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1142 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 KA PK P+ ++T A +D K A+P G S EA Sbjct: 1143 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1191 Query: 215 TKPKESARQDEG 226 T P++S + +G Sbjct: 1192 TTPQKSRKPKKG 1203 Score = 47.0 bits (110), Expect = 1e-05 Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111 K E+ + + E+ + E P A ++ +A P + P KAG + Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 166 K + +E + + ++ E+A +A T + K + T P A AK P Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582 Query: 167 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210 + A A AT+PA A Q P E SS+ ++ E Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626 Score = 44.3 bits (103), Expect = 9e-05 Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%) Query: 27 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 86 P K AA ++Q + +R E+ D + A A N P+ + K +T Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434 Query: 87 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 133 G+ P PGK G E SE E +++ P A A ++E Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494 Query: 134 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 KAG + + DNS SS+ A E + PAA+ Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550 Query: 175 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 215 TAA A TT +A+ A + Q P + G ++ + AV Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610 Query: 216 KPKESARQDEGKEEEPE 232 +P E + E + E E Sbjct: 611 RPAEDSSSSEESDSEEE 627 Score = 42.4 bits (98), Expect = 4e-04 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%) Query: 26 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 77 K + KA+ AA + + S G + + +++ + N ++ +A G Sbjct: 710 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 769 Query: 78 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 130 V G+ TA A TG + D E+ SEE+ K G +AA APA Sbjct: 770 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 827 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 177 + G+A T K + + K +D+ + E +D PAAVT+A Sbjct: 828 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886 Query: 178 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 211 A TPA AA+ KA A T SS++E+ N+ Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946 Query: 212 VDETKP--------------KESARQDEGKEEEPEADQ 235 + P KES+R +GK++E A Q Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 984 Score = 41.6 bits (96), Expect = 6e-04 Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%) Query: 72 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 131 A G+ G+ +++E ++ + D KA E + + A PA Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243 Query: 132 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 185 + A A K D+ SS+ E+ PA + QA + AA+ PA E Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303 Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 A PP +TG A +A + +S+ ++ EEE A Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348 Score = 39.3 bits (90), Expect = 0.003 Identities = 52/228 (22%), Positives = 74/228 (32%), Gaps = 21/228 (9%) Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKA-ATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 + K+ +D E + E +A A AT AS + L K+ +A + Sbjct: 72 QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 A K + + G T A + A T E + EG AA Sbjct: 132 AGK-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185 K G A +S D S SS D K K V AA+ PA Sbjct: 187 --------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKG 232 Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 AT PP + G + ++ +E S + +EE P A Sbjct: 233 TPGKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279 Score = 37.7 bits (86), Expect = 0.009 Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%) Query: 10 QVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67 + EK D+ + ++ D +A A T QA I + K +K + +A+ Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579 Query: 68 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 121 APV G + K G T+ A ++PA +P E + E E++ G A T Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635 Query: 122 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 154 A + KA S AE + +++S + S S Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 199 +A +PA+ + A AAA P+A+ AAA+A + P++ Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755 Query: 200 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 G +S + + +D G EE +E A Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804 Score = 32.7 bits (73), Expect = 0.28 Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%) Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 125 ++ K+ + ++DG +++G T ++ PA+ P + + A A Sbjct: 964 SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1011 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185 A ++ +G A++ S S +A+ +PK +V A T A ++ +E Sbjct: 1012 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1070 Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234 D++ ++ E GE Q ++ + T + +E E E D Sbjct: 1071 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1117 Score = 30.4 bits (67), Expect = 1.4 Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%) Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114 K D + + KD+ DG ++ +P TG K G + + KKG Sbjct: 1147 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1203 Query: 115 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 157 G+ A Q+ +S K + E K D + S + Sbjct: 1204 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1263 Query: 158 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 +++ D PAA T + A E A + + + T + + + Sbjct: 1264 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1323 Query: 215 TKPKESARQDEGKEEEPEAD 234 K + + +G ++EPE + Sbjct: 1324 EKKGKGSLGSQGAKDEPEEE 1343 >gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] Length = 2400 Score = 63.5 bits (153), Expect = 1e-10 Identities = 65/244 (26%), Positives = 115/244 (47%), Gaps = 32/244 (13%) Query: 10 QVEKNDDDQKIEQDGIKPEDKAH-KAATKIQASFRGHITRKKLKGE---KKDDVQAAEAE 65 ++++ +++ + E DG++ + K+ + A +++ +K +G+ + D V+A EAE Sbjct: 2008 EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE------TQKTEGDAQPESDGVEAPEAE 2061 Query: 66 ANKKDEAPVADGVEKKGEGTTTAE-----AAPATG-SKPDEPG-KAGETPSEEKKGEGDA 118 +EA A+G ++ EG E A A G ++P+ G +A E E +K EG Sbjct: 2062 ----EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117 Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA--AVTA 176 A E P S +A AE E+ + S +A+DA + +P+ + A A Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQPE-----SEGVEAQDAEGEAQPESEGIEAQEAEEE 2172 Query: 177 AAATTPAAEDAAAKATAQPPTETGESSQAE----ENIEAVDETKPKESARQDEGKEEEPE 232 A E A+ AQP +E E+ +AE +E V+ + +E A+ + E PE Sbjct: 2173 AQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPE 2232 Query: 233 ADQE 236 A+ E Sbjct: 2233 AEGE 2236 Score = 62.8 bits (151), Expect = 3e-10 Identities = 64/244 (26%), Positives = 102/244 (41%), Gaps = 42/244 (17%) Query: 10 QVEKNDDDQKIEQDGIKP---EDKAHKAATKIQASFRGHITRKKLKGEKKD-DVQAAEAE 65 + +K + D + E DG++ E++A +A ++Q + + E +D D Q AE E Sbjct: 2040 ETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA------EGEAHPESEDVDAQEAEGE 2093 Query: 66 ANKKDE---APVADGVEKKGEGT----TTAEAAPATGS--KPDEPGKA------------ 104 A + E AP A+G +K EG T EA P + P+ G+A Sbjct: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153 Query: 105 -GETPSEEKKGEGDAATEQAAPQ-----APASSEEKAGSAETESATKASTDNSPSSKAED 158 GE E + E A E+A P+ AP + E +E A +A + P + + Sbjct: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213 Query: 159 AP-----AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVD 213 AP A+ EP+ + P A A + K + Q G+S +A E+ V Sbjct: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273 Query: 214 ETKP 217 E +P Sbjct: 2274 EDRP 2277 Score = 58.5 bits (140), Expect = 5e-09 Identities = 61/204 (29%), Positives = 95/204 (46%), Gaps = 28/204 (13%) Query: 60 QAAEAEANKKDEAPVADGVEKKGE--GTTTAEAAPATG-SKPDEPG-KAGETPSEEKKGE 115 Q + E N + EA A G + G+ G EA A G ++P+ G +A E + ++ E Sbjct: 1806 QGSGHEDNLQGEA-AAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE 1864 Query: 116 GDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE---EPKQADVPA 172 G+A E +AP + E +E +A + P S+ +AP E +P+ V A Sbjct: 1865 GEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA 1924 Query: 173 AVT-------AAAATTPAAEDAA--AKATAQPPTETGESSQAE-------ENIEAVD--- 213 T + A AE+AA A+ QP +E ES +AE E++EA++ Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV 1984 Query: 214 ETKPKESARQDEGKE-EEPEADQE 236 ET+ E Q E ++ E PEA+ E Sbjct: 1985 ETQEAEGEAQPESEDVEAPEAEGE 2008 Score = 57.4 bits (137), Expect = 1e-08 Identities = 54/195 (27%), Positives = 81/195 (41%), Gaps = 20/195 (10%) Query: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE-------EKK 113 A EAE + E+ V + E + E +E A + + GE E E + Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006 Query: 114 GEGDAATEQAAPQA------PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 167 GE A E+A P++ P S E+A E E+ K D P S +AP EE Q Sbjct: 2007 GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQ-KTEGDAQPESDGVEAPEAEEEAQ 2065 Query: 168 ADVPAAVTAAAATTPAAEDA---AAKATAQPPTETGESSQAE---ENIEAVDETKPKESA 221 A P +ED A+ AQP +E E+ +AE + E ++ + + A Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125 Query: 222 RQDEGKEEEPEADQE 236 + + E PEA+ E Sbjct: 2126 QPESEGIEAPEAEGE 2140 Score = 57.0 bits (136), Expect = 1e-08 Identities = 55/196 (28%), Positives = 89/196 (45%), Gaps = 27/196 (13%) Query: 54 EKKDDVQAAEAEANKKDE---APVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPS 109 E + D Q AE EA + E AP A+G + + E T EA +P+ G E P Sbjct: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEV--QPESEG--AEAPE 1910 Query: 110 EEKKGEGDA----ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK---AEDAPAK 162 EK+ + + A E P S +A AE E+A +A P S+ +++A + Sbjct: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAE-EAAQEAEGQTQPESEVIESQEAEEE 1969 Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222 +P+ DV A E A+ AQP +E E+ +AE ++ +E E+ Sbjct: 1970 AQPESEDVEALEVEV-------ETQEAEGEAQPESEDVEAPEAEGEMQEAEE----EAQP 2018 Query: 223 QDEGKEEEPEADQEHA 238 + +G E +P+++ E A Sbjct: 2019 ESDGVEAQPKSEGEEA 2034 Score = 52.4 bits (124), Expect = 3e-07 Identities = 52/201 (25%), Positives = 86/201 (42%), Gaps = 21/201 (10%) Query: 53 GEKKDDVQAAEAEANKKDEAPVADG----VEKKGEGTTTAEAAPATGSKPDE--PGKAG- 105 GE + D A E E + A E++GEG + GS ++ G+A Sbjct: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAA 1820 Query: 106 ---ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-- 160 + P + EG A E P S +A AE + A +A + P S+ +AP Sbjct: 1821 GGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD-AQEAEGEAQPESEDVEAPEA 1879 Query: 161 ---AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVD 213 A+ E + + P A + AE A+ AQP TE+ E+ + E E + Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE 1939 Query: 214 ETKPKESARQDEGKEEEPEAD 234 + +E+A++ EG + +PE++ Sbjct: 1940 AQEAEEAAQEAEG-QTQPESE 1959 Score = 51.6 bits (122), Expect = 6e-07 Identities = 45/182 (24%), Positives = 84/182 (46%), Gaps = 8/182 (4%) Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114 + + +A EAE + E + +E +GE +E A A ++ G+T E + Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVI 1961 Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-AKEEPKQADVPAA 173 E A E+A P+ S + +A E E+ +A + P S+ +AP A+ E ++A+ A Sbjct: 1962 ESQEAEEEAQPE---SEDVEALEVEVET-QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ 2017 Query: 174 VTA-AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232 + P +E A+ +T +Q E + V+ + +E A++ EG+ +E E Sbjct: 2018 PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES--DGVEAPEAEEEAQEAEGEVQEAE 2075 Query: 233 AD 234 + Sbjct: 2076 GE 2077 Score = 50.8 bits (120), Expect = 1e-06 Identities = 53/201 (26%), Positives = 89/201 (44%), Gaps = 19/201 (9%) Query: 55 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 114 + +DV+A EAE + E+ + E + E +E A A ++ + + + E +G Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEG 1929 Query: 115 EGDAATEQA-APQAPASSEEKAGSAETESATKAS--TDNSPSSKAEDAPAKE---EPKQA 168 E + +E A A +A +++E G + ES S + ++ED A E E ++A Sbjct: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEA 1989 Query: 169 DVPAAVTAAAATTPAAEDAAAKAT--AQPPTETGES---SQAEENIEAVDETKPKESARQ 223 + A + P AE +A AQP ++ E+ S+ EE E ET+ E Q Sbjct: 1990 EGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQ 2049 Query: 224 DEG--------KEEEPEADQE 236 E +EE EA+ E Sbjct: 2050 PESDGVEAPEAEEEAQEAEGE 2070 Score = 33.9 bits (76), Expect = 0.13 Identities = 41/203 (20%), Positives = 79/203 (38%), Gaps = 37/203 (18%) Query: 10 QVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK- 68 Q+E+ ++ ++++G++ E+ +G+++++ Q E E Sbjct: 1321 QLEETKTEEGLQEEGVQLEETKETEG----------------EGQQEEEAQLEEIEETGG 1364 Query: 69 ---KDEAPVADGVEKKGEGTTTAEAA---------PATGSKPDEPGKAGETPSEEKKGEG 116 ++E + V++ EG EA P GS + +P + E Sbjct: 1365 EGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQED 1424 Query: 117 DAATEQAAPQAPASSEE--KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 D E+ A +A AS+E G+ E ++ PS+ + ++ EP P A Sbjct: 1425 DPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484 Query: 175 ------TAAAATTPAAEDAAAKA 191 T A T AAE +++ A Sbjct: 1485 MMGQEHTQAQPTQGAAERSSSVA 1507 Score = 30.8 bits (68), Expect = 1.1 Identities = 25/120 (20%), Positives = 50/120 (41%), Gaps = 9/120 (7%) Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 142 +G +A + G++ G GE P G G EQ P + E+ S+++ + Sbjct: 478 DGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSA 537 Query: 143 ATKASTDNSP--------SSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 194 +T + +S KA +++E + PA+ A + ++ ++D A+ Q Sbjct: 538 STGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPAS-PALSLSSLRSDDLQAETQGQ 596 Score = 29.6 bits (65), Expect = 2.4 Identities = 41/210 (19%), Positives = 74/210 (35%), Gaps = 21/210 (10%) Query: 8 TKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQAS------FRGHITRKKLKGEKKDDVQA 61 TKQV + + ++ QDG P ++T+ QAS G + + L G V Sbjct: 683 TKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTP 742 Query: 62 AEAEANKKDEAP-VADGVEKKGE-GTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119 A +P A G+ G+ T AP D K+G E+ + Sbjct: 743 AVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQP 802 Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE-----------EPKQA 168 + Q + G + ++ T P+ +A+ P+ E P+ Sbjct: 803 SSPLVLQVGRPEQGAVGPHRSHCCSQPGT--QPAQEAQRGPSPEASWLCGRYCPTPPRGR 860 Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTE 198 P +++ +T ++ + A+ P E Sbjct: 861 PCPQRRSSSCGSTGSSHQSTARGPGGSPQE 890 Score = 29.3 bits (64), Expect = 3.1 Identities = 42/195 (21%), Positives = 66/195 (33%), Gaps = 22/195 (11%) Query: 56 KDDVQAAEAEANKKDEAPVAD-GVEKKGEGT---TTAEAAPATGSKPDEPGKAGETPSEE 111 KD + E + KD P D G ++ G T ++A P GS + S Sbjct: 1142 KDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGV 1201 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 171 G + +++ P + + + TE K S S E E +Q P Sbjct: 1202 DISSGSGGSGESS--VPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFP 1259 Query: 172 AAVTAAAATTPAAEDAA----------------AKATAQPPTETGESSQAEENIEAVDET 215 + A A ED A A+ T Q + E+ + E +E Sbjct: 1260 TFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEA 1319 Query: 216 KPKESARQDEGKEEE 230 E + +EG +EE Sbjct: 1320 VQLEETKTEEGLQEE 1334 >gi|153070260 myristoylated alanine-rich protein kinase C substrate [Homo sapiens] Length = 332 Score = 61.6 bits (148), Expect = 6e-10 Identities = 49/196 (25%), Positives = 84/196 (42%), Gaps = 24/196 (12%) Query: 30 KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD-------EAPVADGVEKKG 82 KA AT ++ +K+ +K + + NKK+ EAP A+G + + Sbjct: 137 KAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEA 196 Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA--------PASSEEK 134 G A AA A + ++ GE + ++G ++A PQ PAS E K Sbjct: 197 AGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETK 256 Query: 135 AGSAET--------ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED 186 A + E+ A+ +PS+ AP ++E A+ PAA A++A +++ Sbjct: 257 AAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEEPAAAAASSACAAPSQE 316 Query: 187 AAAKATAQ-PPTETGE 201 A + + + PP E E Sbjct: 317 AQPECSPEAPPAEAAE 332 Score = 52.4 bits (124), Expect = 3e-07 Identities = 64/222 (28%), Positives = 87/222 (39%), Gaps = 61/222 (27%) Query: 70 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129 D +P A K E A A +P G +PS +KGE AA AAP+A A Sbjct: 44 DASPAAAESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAA---AAPEAGA 100 Query: 130 SSEEKAG-------------SAETESATKASTDNSPSSKAED----APAKEEPK------ 166 S EK +AE E+A+ AS+ +SP KAED +P+ E PK Sbjct: 101 SPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSP--KAEDGATPSPSNETPKKKKKRF 158 Query: 167 ------------------------QADVPAAV----TAAAATTPAAEDAAAKATAQPPTE 198 +A+ PAA AA AA +A A + Q Sbjct: 159 SFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAP 218 Query: 199 TGESSQAEENIEAVD--ETKPKESARQDEGKEEEPEADQEHA 238 E++ EE D E KP+E+A E+ P +D+ A Sbjct: 219 GEEAAAGEEGAAGGDPQEAKPQEAA---VAPEKPPASDETKA 257 Score = 46.6 bits (109), Expect = 2e-05 Identities = 66/253 (26%), Positives = 89/253 (35%), Gaps = 41/253 (16%) Query: 22 QDGIKPEDKAH---KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK---KDEAPVA 75 + G K E +A+ AA K + + G EK + AA EA + EAP Sbjct: 51 ESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAE 110 Query: 76 DGVEKKGEGTTT----AEAAPATGSKPDE----PGKAGETPSEEKKG------------- 114 + G T A AA +T S E P + ETP ++KK Sbjct: 111 GEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFS 170 Query: 115 ------EGDAATEQAAPQAPASSEEKAGSAETESATK-ASTDNSPSSKAEDAPAKEEPKQ 167 E E AP A +E AG A +A A++ ++ E+A A EE Sbjct: 171 FKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAA 230 Query: 168 ADVPA-AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE------NIEAVDETKPKES 220 P A AA P A+ + A E +AEE EA P Sbjct: 231 GGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAP 290 Query: 221 ARQDEGKEEEPEA 233 Q+ EEP A Sbjct: 291 PEQEAAPAEEPAA 303 Score = 45.1 bits (105), Expect = 6e-05 Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 27/151 (17%) Query: 63 EAEANKKDEAPVADGVEK-----KGEGTTTAEAAPA---TGSKPDEPGKAGETPSEEKKG 114 EA A + EA VA K G +A+PA +G+K +E G P+ +K+ Sbjct: 13 EAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAK-EELQANGSAPAADKEE 71 Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEE------PKQA 168 A + A+P A E A +A A SP K +APA+ E P A Sbjct: 72 PAAAGSGAASPSAAEKGEPAAAAAPEAGA-------SPVEK--EAPAEGEAAEPGSPTAA 122 Query: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTET 199 + AA A++ ++P AED AT P ET Sbjct: 123 EGEAASAASSTSSPKAEDG---ATPSPSNET 150 Score = 41.6 bits (96), Expect = 6e-04 Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 17/134 (12%) Query: 81 KGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE----------QAAPQAPAS 130 KGE A P + P KA + K GDA+ QA APA+ Sbjct: 11 KGEA---AAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQANGSAPAA 67 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED---- 186 +E+ +A + +A+ ++ + + A A P + + PA AA +P A + Sbjct: 68 DKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAA 127 Query: 187 AAAKATAQPPTETG 200 +AA +T+ P E G Sbjct: 128 SAASSTSSPKAEDG 141 Score = 37.7 bits (86), Expect = 0.009 Identities = 42/139 (30%), Positives = 54/139 (38%), Gaps = 25/139 (17%) Query: 115 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAE----------DAPA--K 162 +G+AA E+ A ASS KA E K + D SP++ APA K Sbjct: 11 KGEAAAERPGEAAVASSPSKANGQEN-GHVKVNGDASPAAAESGAKEELQANGSAPAADK 69 Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQP----------PTETGESSQAEENIEAV 212 EEP A AA +AA A AA +A A P E G + AE EA Sbjct: 70 EEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEG--EAA 127 Query: 213 DETKPKESARQDEGKEEEP 231 S + ++G P Sbjct: 128 SAASSTSSPKAEDGATPSP 146 >gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo sapiens] Length = 916 Score = 61.2 bits (147), Expect = 7e-10 Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 28/234 (11%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 K VE+ ++ K+E + + E+ ++ S +K EKK+ A + Sbjct: 451 KFVEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEE 494 Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQA 127 K+E P A+ E A+ +P + P+ + GE EE + E + E A + QA Sbjct: 495 KEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 548 Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTP 182 EK GS+E E + + ++ E+A AKEE K + V A A Sbjct: 549 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 608 Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236 E A + P E G+S + +E ++ +S +++GK P++ E Sbjct: 609 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 662 Score = 49.7 bits (117), Expect = 2e-06 Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%) Query: 13 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72 K + + E+ +PE + + A K K+ +GEK+++ + E ++DE Sbjct: 485 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 542 Query: 73 PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 117 +D G EK+G EG T AEA E +A E E+K E Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 595 Query: 118 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 177 A E+ A EKA S K+ + S +P +E+ K + VP + Sbjct: 596 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 650 Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 235 +P + + P +++ +A+ + V+E K K + E KEEE + + Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710 Query: 236 E 236 E Sbjct: 711 E 711 Score = 44.7 bits (104), Expect = 7e-05 Identities = 50/233 (21%), Positives = 87/233 (37%), Gaps = 37/233 (15%) Query: 6 RRTKQVEKNDDDQKIEQDGI------KPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV 59 + K+VE+ ++ +++ + KPE KA K +G K E+K Sbjct: 583 KEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 641 Query: 60 QAAEAEANKKDEAPVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDA 118 ++ +K ++PV VE+KG+ + P E S+ + G+G+ Sbjct: 642 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 701 Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178 E+ A EEK E K +D P K++ Sbjct: 702 KEEEEKEVKEAPKEEKVEKKE--------------EKPKDVPEKKK-------------- 733 Query: 179 ATTPAAEDAAAK-ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230 A +P E+A A+ T + + +E + + + K KE A + G EEE Sbjct: 734 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 786 >gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo sapiens] Length = 540 Score = 61.2 bits (147), Expect = 7e-10 Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 28/234 (11%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 K VE+ ++ K+E + + E+ ++ S +K EKK+ A + Sbjct: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEE 118 Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQA 127 K+E P A+ E A+ +P + P+ + GE EE + E + E A + QA Sbjct: 119 KEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 172 Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTP 182 EK GS+E E + + ++ E+A AKEE K + V A A Sbjct: 173 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 232 Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236 E A + P E G+S + +E ++ +S +++GK P++ E Sbjct: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 286 Score = 49.7 bits (117), Expect = 2e-06 Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%) Query: 13 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72 K + + E+ +PE + + A K K+ +GEK+++ + E ++DE Sbjct: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 166 Query: 73 PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 117 +D G EK+G EG T AEA E +A E E+K E Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 219 Query: 118 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 177 A E+ A EKA S K+ + S +P +E+ K + VP + Sbjct: 220 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 274 Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 235 +P + + P +++ +A+ + V+E K K + E KEEE + + Sbjct: 275 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 334 Query: 236 E 236 E Sbjct: 335 E 335 Score = 44.7 bits (104), Expect = 7e-05 Identities = 50/233 (21%), Positives = 87/233 (37%), Gaps = 37/233 (15%) Query: 6 RRTKQVEKNDDDQKIEQDGI------KPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV 59 + K+VE+ ++ +++ + KPE KA K +G K E+K Sbjct: 207 KEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 265 Query: 60 QAAEAEANKKDEAPVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDA 118 ++ +K ++PV VE+KG+ + P E S+ + G+G+ Sbjct: 266 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 325 Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178 E+ A EEK E K +D P K++ Sbjct: 326 KEEEEKEVKEAPKEEKVEKKE--------------EKPKDVPEKKK-------------- 357 Query: 179 ATTPAAEDAAAK-ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230 A +P E+A A+ T + + +E + + + K KE A + G EEE Sbjct: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 410 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 59.7 bits (143), Expect = 2e-09 Identities = 53/224 (23%), Positives = 95/224 (42%), Gaps = 15/224 (6%) Query: 22 QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKK 81 ++ IK +K+ K ++ +++ E++ + + E + + E A+G E++ Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEE 500 Query: 82 GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE 141 + EAA + ++P+E K E E+A A S EKA S E Sbjct: 501 TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE----KEEAKSPAEVKSPEKAKSPAKE 556 Query: 142 SATKASTDNSPSSKAEDAPAK-EEPKQADVPA---------AVTAAAATTPAAEDAAAKA 191 A SP + +PA+ + P++A PA A + A +P E+A + A Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616 Query: 192 TAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235 A+ P + S AE ++ KE A+ E K + PE ++ Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE-KAKSPEKEE 659 Score = 56.6 bits (135), Expect = 2e-08 Identities = 57/225 (25%), Positives = 88/225 (39%), Gaps = 17/225 (7%) Query: 25 IKPEDKA-HKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA-PVADGVEKKG 82 +K E K KA + ++ + K + K DV++ EA+ K+EA AD +K Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785 Query: 83 EGTTTAEA-APATGSKP-DEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAET 140 + E +P P E KA E +K+ E+ PQ E + E Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845 Query: 141 ESATKASTDNSPSSKAEDAPAKEEPK----QADVPAAVTAAAATTPAAEDAAAKATAQPP 196 ++ T+ SK E+AP KE PK + PA + A ++ A P Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905 Query: 197 TETGESSQAEENIEAVDETKPKESA-----RQDEGKEEEPEADQE 236 E +A +E ++ KPKE D+ K +EP E Sbjct: 906 PE----KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946 Score = 55.5 bits (132), Expect = 4e-08 Identities = 56/240 (23%), Positives = 108/240 (45%), Gaps = 15/240 (6%) Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEA 66 + K EK +K E++ + E++ + + + K+ +G++++ + EAE Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496 Query: 67 NKKDE----APVADGVEKKGEGTTTAEA-APATGSKPD--EPGKAGETPSEEKKGEGDAA 119 +++ A A EK+ + EA +PA P+ E E S EK Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556 Query: 120 TEQAAPQAPASSEEKAGS-AETESATKASTDNSPSSKAEDAPAK-EEPKQADVPA---AV 174 ++ P+A + +E+A S AE +S KA SP+ + +PA+ + P++A P A Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAK---SPAKEEAKSPAEAKSPEKAKSPVKEEAK 613 Query: 175 TAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234 + A A +P E+A + A + P + ++ E ++ KE A+ E + +A+ Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673 Score = 55.5 bits (132), Expect = 4e-08 Identities = 61/257 (23%), Positives = 107/257 (41%), Gaps = 31/257 (12%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEAN 67 ++ E +++ K E+ G + E + + TK + K+ K K++ ++ AEA++ Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533 Query: 68 KKDEA--PVADGVEKKGEGTTTAEA-APATGSKPDE-----------PGKAGETPSEEKK 113 +K+EA P +K + EA +P P++ P KA EE K Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593 Query: 114 GEGDAAT---------EQAAPQAPASS---EEKAGSAETESATKASTDNSPSSKAED--- 158 +A + E+A A A S EE AE +S KA + +K+ + Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653 Query: 159 APAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK 218 +P KEE K + + A A +P + KA A+ P + + E ++ K Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK 713 Query: 219 ESARQDEGKEEEPEADQ 235 E A+ E K + P ++ Sbjct: 714 EEAKSPE-KAKSPVKEE 729 Score = 53.9 bits (128), Expect = 1e-07 Identities = 53/194 (27%), Positives = 86/194 (44%), Gaps = 16/194 (8%) Query: 47 TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKP--DEPGKA 104 T K+K E+K V K ++ V VE++ E T E K +E GK Sbjct: 434 THIKVKSEEKIKV------VEKSEKETVI--VEEQTEETQVTEEVTEEEEKEAKEEEGKE 485 Query: 105 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-E 163 E EE+ G+ T+ + AS E++A S E A + SP + +PA+ + Sbjct: 486 EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545 Query: 164 EPKQADVPA---AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220 P++A PA A + A +P E+A + A + P + S A+E ++ E K E Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAKSPEK 603 Query: 221 ARQDEGKEEEPEAD 234 A+ +E + A+ Sbjct: 604 AKSPVKEEAKSPAE 617 Score = 52.8 bits (125), Expect = 3e-07 Identities = 50/222 (22%), Positives = 98/222 (44%), Gaps = 19/222 (8%) Query: 16 DDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEANKKDEAPV 74 ++ K + PE + K+ ++++ +K K K++ ++ AEA++ +K ++PV Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSP-------EKAKSPAKEEAKSPAEAKSPEKAKSPV 608 Query: 75 ADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEK 134 + + E + + + ++ P KA EE K A + + + A S EK Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE---KEEAKSPEK 665 Query: 135 AGS---AETESATKASTDNSPSSKAED---APAKEEPKQADVPAAVTAAAATTPAAEDAA 188 A S AE +S KA + +K+ + +P KEE K + + A +P + Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725 Query: 189 AKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230 K A+ P + S +E ++ ++ K E A+ + K E Sbjct: 726 VKEEAKTPEKA--KSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765 Score = 51.6 bits (122), Expect = 6e-07 Identities = 56/232 (24%), Positives = 99/232 (42%), Gaps = 36/232 (15%) Query: 7 RTKQVEKNDDDQKIEQDGIKPEDK-AHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 +T V+ + +++ P DK KA + ++ + + +K K K+D +A E E Sbjct: 757 KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK---SPEKAKSPLKEDAKAPEKE 813 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQA 123 KK+E E+K + E K E KA TP E+K + + A ++ Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPP-----KKAEEEKAPATPKTEEKKDSKKEEAPKKE 868 Query: 124 APQAPASSEEKAGSAET--ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATT 181 AP+ P E+K + E ES +A + + K P KE P + +V Sbjct: 869 APK-PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV----------- 916 Query: 182 PAAEDAAAKATAQPPTETGESSQAEENIEAVDETKP---KESARQDEGKEEE 230 K A+P +T + + ++ +A + +KP KE+A + + +EE Sbjct: 917 --------KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960 Score = 50.4 bits (119), Expect = 1e-06 Identities = 46/197 (23%), Positives = 76/197 (38%), Gaps = 20/197 (10%) Query: 54 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKK 113 EK++ AE ++ +K ++P + + E + +A + P +A EE K Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627 Query: 114 GEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSP------SSKAEDAPAKEE 164 + + + A + A S EKA S E E A SP S + +P K E Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687 Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR-- 222 K + A +P E+A + A+ P + S + +E K E A+ Sbjct: 688 AKSPE--------KAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739 Query: 223 -QDEGKEEEPEADQEHA 238 ++E K E E A Sbjct: 740 VKEEAKSPEKAKSPEKA 756 Score = 50.1 bits (118), Expect = 2e-06 Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 15/228 (6%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEAN 67 K EK + E +K +KA A + S + +K K K++ ++ AEA++ Sbjct: 565 KSPEKEEAKSPAE---VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621 Query: 68 KKDEA--PVADGVEKKGEGTTTAEA-APATGSKPD-EPGKAGETPSEEKKGEGDAATEQA 123 K+EA P +K + T EA +P P+ E K+ E K E + + Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681 Query: 124 AP-QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182 +P +A A S EKA S E A S + + S E+A + E+ K A T A +P Sbjct: 682 SPVKAEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739 Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230 E+A + A+ P E ++ + +T KE AR K E Sbjct: 740 VKEEAKSPEKAKSP----EKAKTLDVKSPEAKTPAKEEARSPADKFPE 783 Score = 50.1 bits (118), Expect = 2e-06 Identities = 54/224 (24%), Positives = 92/224 (41%), Gaps = 27/224 (12%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 K++ K ++ + ++ KP++ K K + T K EKKD +K Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT--EEKKD---------SK 860 Query: 69 KDEAPVADG----VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124 K+EAP + VE+K E +K +E + P+ EK+ A + Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKE-----APAKVE 915 Query: 125 PQAPASSEEKAGSAETE-SATKASTDNSPSSKAEDAPAKEEPKQ--ADVPAAVTAAAATT 181 + A +EK A+ E KA + P+ K E AP K++ K+ A P A Sbjct: 916 VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975 Query: 182 PAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDE 225 + +K ++P E E S + + ++KP E A +D+ Sbjct: 976 KEDDKTLSKEPSKPKAEKAEKSSSTDQ----KDSKPPEKATEDK 1015 Score = 47.0 bits (110), Expect = 1e-05 Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 17/196 (8%) Query: 49 KKLKGEKKDDVQAAE-AEANKKDEAPVADGVEK--KGEGTTTAEAAPATGSKPDEPGKAG 105 +K K K++ ++ E A++ +K+EA + + K E + +A ++ P KA Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695 Query: 106 ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 165 EE K A ++ + A S EKA S E A SP + +P K + Sbjct: 696 SPVKEEAKSPEKA---KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKS 752 Query: 166 KQADVPAAVTAAAATTPAAEDA---------AAKATAQPPTETGESSQA--EENIEAVDE 214 + V + A TPA E+A AK+ + ++ E +++ +E+ +A ++ Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK 812 Query: 215 TKPKESARQDEGKEEE 230 PK+ + KEEE Sbjct: 813 EIPKKEEVKSPVKEEE 828 >gi|24415404 MDN1, midasin homolog [Homo sapiens] Length = 5596 Score = 57.8 bits (138), Expect = 8e-09 Identities = 45/234 (19%), Positives = 96/234 (41%), Gaps = 10/234 (4%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 ++ ++ ++D K E+ G +++ + K G+ + K + +KK++ + AEA+ Sbjct: 4784 EEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGG 4843 Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP------SEEKKGEGDAATEQ 122 + E + + ++++ + K EP +A + P SE+K G D E+ Sbjct: 4844 QGEDKINEQIDERDYDENEVDPYHGNQEKVPEP-EALDLPDDLNLDSEDKNGGEDTDNEE 4902 Query: 123 AAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182 + P +EK A E+ + T+ + +E P + D Sbjct: 4903 GEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDD---KAEGEEEMDT 4959 Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236 A+D A P + E Q+ E + + + E+ D+G + + E ++E Sbjct: 4960 GADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEERE 5013 Score = 40.8 bits (94), Expect = 0.001 Identities = 42/184 (22%), Positives = 71/184 (38%), Gaps = 24/184 (13%) Query: 53 GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 112 GE D+ + E + E P G E + G T E P EP E PSE+ Sbjct: 4895 GEDTDNEEGEEENPLEIKEKPEEAGHEAEERGET--ETDQNESQSPQEPE---EGPSEDD 4949 Query: 113 KGEGDAATEQAA----------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 162 K EG+ + A P+ + ++++ + + A + +N P+ + + Sbjct: 4950 KAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEE 5009 Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222 EE + +D V A E + Q E +++QA E A E KE + Sbjct: 5010 EEREDSDTEEQV------PEALERKEHASCGQTGVENMQNTQAMELAGAAPE---KEQGK 5060 Query: 223 QDEG 226 ++ G Sbjct: 5061 EEHG 5064 Score = 38.5 bits (88), Expect = 0.005 Identities = 44/237 (18%), Positives = 91/237 (38%), Gaps = 23/237 (9%) Query: 7 RTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKG------EKKDDVQ 60 + K+ ++ + G +P+++ + + + + RK+ E + Q Sbjct: 4986 KDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQ 5045 Query: 61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSK-----PDEPGKAGETPSEEKKGE 115 A E ++ G E+ G G A A S + T S ++K Sbjct: 5046 AMELAGAAPEKE---QGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRK-P 5101 Query: 116 GDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT 175 G A E++ ++ + +T+S + P ++ EDA A E KQ Sbjct: 5102 GQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQ-------- 5153 Query: 176 AAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232 + A D A+K Q ++G+ + EE + + +T+ +E + + ++ +PE Sbjct: 5154 GSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPE 5210 >gi|157738619 smoothelin-like 1 [Homo sapiens] Length = 512 Score = 56.2 bits (134), Expect = 2e-08 Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 12/185 (6%) Query: 65 EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124 E+ K+++AP DG+ + +G S+ + GK + +E KK +G+ Sbjct: 67 ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE-DAEAELKKEDGEKEETTVG 125 Query: 125 PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ------ADVP---AAVT 175 Q +E+ S E+ K ST S KAE+ AK E Q D P A V Sbjct: 126 SQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVE 185 Query: 176 AAAATTPAAEDAAAK--ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 A T + E+ + + +P + + E+ +AV E + K ++ +GKEE Sbjct: 186 EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHG 245 Query: 234 DQEHA 238 +E A Sbjct: 246 AKEEA 250 Score = 50.4 bits (119), Expect = 1e-06 Identities = 53/219 (24%), Positives = 81/219 (36%), Gaps = 43/219 (19%) Query: 49 KKLKGEKKDDVQAA-EAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------- 100 K+ K +D + A + EAN DE V E G+ AE G K + Sbjct: 70 KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129 Query: 101 PGKAGETPSEEKKGEGDAAT--------------------------EQAAPQAPASSEEK 134 G+ ET SE K+ E +T ++ P+A E+ Sbjct: 130 TGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDA 189 Query: 135 AGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 194 +++ E+ + P KA D AK E ++A V A E+A A Sbjct: 190 KTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK-- 247 Query: 195 PPTETGESSQAEENIEAVDETKP-KESARQDEGKEEEPE 232 E + A+E E +E +P S Q++ E+EPE Sbjct: 248 ------EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPE 280 Score = 47.8 bits (112), Expect = 9e-06 Identities = 46/195 (23%), Positives = 79/195 (40%), Gaps = 21/195 (10%) Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108 KK GEK++ ++ +K+E ++ E T +E KA E Sbjct: 113 KKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQ-----------KAEEKE 161 Query: 109 SEEKKGEGDAATEQAAPQAPASSEEKAG--SAETESATKASTDNSPSSKAEDAPAKEEPK 166 ++ + G+ A ++ P+ A+ EE+ +++ E+ + P KA D AK E + Sbjct: 162 AKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQ 221 Query: 167 QADVPAAVTAAA--------ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK 218 +A V A A A E+A AK A+ E S +EE + V++ Sbjct: 222 KAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEG 281 Query: 219 ESARQDEGKEEEPEA 233 + EE PE+ Sbjct: 282 GAGVIPSSPEEWPES 296 Score = 47.0 bits (110), Expect = 1e-05 Identities = 52/220 (23%), Positives = 81/220 (36%), Gaps = 30/220 (13%) Query: 44 GHITRKKLKGEKKDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSK---- 97 G + E ++ ++ E + ++ +P AD E G G E G Sbjct: 4 GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63 Query: 98 -PDEPGKAGETPSE-----EKKGEGDAATE-------QAAPQAPASSEEKAGSAETESAT 144 P E GK + P+E E +GE + E +A + A +E K E E T Sbjct: 64 PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETT 123 Query: 145 KASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-----PPTET 199 S + + + + KE ++ A+ A A ++ KA A P T Sbjct: 124 VGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKAT 183 Query: 200 GE------SSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 E +SQ E T+PKE A +E K E +A Sbjct: 184 VEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKA 223 Score = 43.5 bits (101), Expect = 2e-04 Identities = 56/228 (24%), Positives = 87/228 (38%), Gaps = 21/228 (9%) Query: 21 EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKD--DVQAAEAEANKKDEAPVADGV 78 E G K E K+ + + S + +K K E+K+ +A+AN +D+ V Sbjct: 128 EMTGRKEETKSEPKEAEEKEST---LASEKQKAEEKEAKPESGQKADANDRDKPEPKATV 184 Query: 79 EKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT----EQAAPQAPASSEEK 134 E++ T + E EP + + EE K E A +A P+ P EE Sbjct: 185 EEEDAKTASQEETGQRKECSTEPKE--KATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242 Query: 135 AGSAETESATKASTDN-------SPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187 A+ E+ K ++ SPS + E KE A V + +P E Sbjct: 243 KHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGH 302 Query: 188 AAKATAQPP--TETGESS-QAEENIEAVDETKPKESARQDEGKEEEPE 232 P +G++S A E+ + P ES E KE+ PE Sbjct: 303 NLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPE 350 Score = 40.8 bits (94), Expect = 0.001 Identities = 46/182 (25%), Positives = 69/182 (37%), Gaps = 8/182 (4%) Query: 8 TKQVEK-NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEA 66 T+ EK D++ K E ED+A + K+ K++ A EAE Sbjct: 205 TEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEP 264 Query: 67 NKKDEAPVADGVEKKGEGTTTAEAAPATGSK-PDEPGKAGETPSEEKKGEGDAATEQAAP 125 E D VEK+ EG A P++ + P+ P G S + G A+ Q +P Sbjct: 265 GSPSEEQEQD-VEKEPEGG--AGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSP 321 Query: 126 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT---AAAATTP 182 A SS + ES + + APA+ +A A+ AA+ P Sbjct: 322 SASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGP 381 Query: 183 AA 184 A Sbjct: 382 TA 383 Score = 36.6 bits (83), Expect = 0.020 Identities = 34/124 (27%), Positives = 51/124 (41%), Gaps = 16/124 (12%) Query: 114 GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAA 173 GE D + E A E+K G + T + ++P APA+E A A Sbjct: 7 GESDCSAE-----AREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAG--KA 59 Query: 174 VTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEE-EPE 232 + T ++ A P E G S++ + +DE K ES R+ GKE+ E E Sbjct: 60 INEGPPTESGKQEKA-------PAEDGMSAELQGEANGLDEVK-VESQREAGGKEDAEAE 111 Query: 233 ADQE 236 +E Sbjct: 112 LKKE 115 >gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sapiens] Length = 699 Score = 55.1 bits (131), Expect = 5e-08 Identities = 57/236 (24%), Positives = 88/236 (37%), Gaps = 29/236 (12%) Query: 12 EKNDDDQKIE--QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 69 + +++DQK + Q G+KP+ KA KA K K K D ++E E K Sbjct: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPK------------KAKSSDSDSDSSSEDEP-PK 181 Query: 70 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG-DAATEQAAPQAP 128 ++ P V K + T A PA + GKA + S D + E+ A P Sbjct: 182 NQKPKITPVTVKAQ--TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239 Query: 129 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ-----------ADVPAAVTAA 177 + K A+T SS +ED+ + EE +Q + VP Sbjct: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299 Query: 178 AATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 + + Q P E+ E S E + + +E KP A + + P A Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355 Score = 52.8 bits (125), Expect = 3e-07 Identities = 53/233 (22%), Positives = 85/233 (36%), Gaps = 30/233 (12%) Query: 14 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK---- 69 + DD + E+ P+ K +A + T + K +D + E E KK Sbjct: 226 SSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTR-KSSSSEDSSSDEEEEQKKPMKN 284 Query: 70 ------DEAPVADGVEKKGEGTT----TAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119 P + KK GT E S D ++ + EEKK A Sbjct: 285 KPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV 344 Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAA 179 +A + P + + S+++ + + D +PS PA ++ PA T + A Sbjct: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK-----PAGTTKNSSNKPAVTTKSPA 399 Query: 180 TTPAAED----------AAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222 PAA KA + E SS+ E+ + V TKPK +A+ Sbjct: 400 VKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452 Score = 50.8 bits (120), Expect = 1e-06 Identities = 58/267 (21%), Positives = 114/267 (42%), Gaps = 46/267 (17%) Query: 7 RTKQVEKNDDDQKIEQDGIK--PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEA 64 + K + +D E++ ++ P KA A ++ G K + ++ + Sbjct: 79 KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLP-PGKAAAKASESSSSEESSDDDD 137 Query: 65 EANKKDEAPVADGVEKKGEGTTTAEAAP--ATGSKPDEPGKAGETPSEEKKGEGDAATEQ 122 E ++K + PV GV+ + + A+A P A S D + + P + +K + T + Sbjct: 138 EEDQKKQ-PVQKGVKPQAKA---AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVK 193 Query: 123 AAPQAPAS--------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 174 A +AP + KA S+ + S++ +S+D+S KA P K PK+ V A Sbjct: 194 AQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKK-QVVAKA 252 Query: 175 TAAAATTPAAEDAAAKATAQ-------------------------PPTETGESSQAEENI 209 AATTP + ++++ ++ PP + +Q + Sbjct: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK-- 310 Query: 210 EAVDETKPKESARQDEGKEEEPEADQE 236 +AV++ +P ES+ +D E + +++E Sbjct: 311 KAVEKQQPVESS-EDSSDESDSSSEEE 336 Score = 46.6 bits (109), Expect = 2e-05 Identities = 49/228 (21%), Positives = 95/228 (41%), Gaps = 16/228 (7%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 +Q ++ +D E D E+K K TK S + K + ++++++++ Sbjct: 316 QQPVESSEDSSDESDSSSEEEK--KPPTKAVVS-KATTKPPPAKKAAESSSDSSDSDSSE 372 Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAP 128 DEAP K GTT + + K P + G T +A Sbjct: 373 DDEAP------SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKA---DS 423 Query: 129 ASSEEKAGSAETESATKASTDNSPSSKAEDA---PAKEEPKQADVPAAVTAAAATTPAAE 185 +SSEE++ S+E E K P + A+ A PAK+ P+ + ++ + ++++ E Sbjct: 424 SSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEE 483 Query: 186 DAAAKATAQPPTE-TGESSQAEENIEAVDETKPKESARQDEGKEEEPE 232 + A + P + G ++ ++ + + S+ D+ EEE E Sbjct: 484 KTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531 Score = 41.6 bits (96), Expect = 6e-04 Identities = 48/233 (20%), Positives = 91/233 (39%), Gaps = 19/233 (8%) Query: 13 KNDDDQKIEQDGIKPEDKAHK--AATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 70 K D E+ E+K K A TK +A+ + ++ + A +A +D Sbjct: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALS-----------LPAKQAPQGSRD 468 Query: 71 EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130 + +D + E T+++A + G A P+ KKG+ +++ ++ + Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEE 528 Query: 131 SEEK---AGSAETES--ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 185 EEK GS ++ A S + + KA +EE ++ V+ + + + Sbjct: 529 EEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588 Query: 186 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 + AAK A+ P Q + + + S+ +EEE E D A Sbjct: 589 NEAAK-EAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVA 640 Score = 37.4 bits (85), Expect = 0.012 Identities = 36/174 (20%), Positives = 61/174 (35%), Gaps = 7/174 (4%) Query: 65 EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 124 E + PVA +KK + + +++ P K P++ A +A+ Sbjct: 65 ERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKAS 124 Query: 125 PQAPASSEEKAGSAETESATKASTDNS--PSSKAEDAP---AKEEPKQADVPAAVTAAAA 179 + SSEE + + E K P +KA AP AK +D + Sbjct: 125 ESS--SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKN 182 Query: 180 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 233 P KA + P + ++ N +A + S+ + EEE A Sbjct: 183 QKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA 236 Score = 30.4 bits (67), Expect = 1.4 Identities = 24/134 (17%), Positives = 53/134 (39%), Gaps = 8/134 (5%) Query: 103 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 162 K+ + P + + G A + + + SE+ + E A P+ + P K Sbjct: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118 Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 222 K ++ ++++ +++D + + P + G QA+ + K +S Sbjct: 119 AAAKASE-------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDS-D 170 Query: 223 QDEGKEEEPEADQE 236 D E+EP +Q+ Sbjct: 171 SDSSSEDEPPKNQK 184 >gi|55956788 nucleolin [Homo sapiens] Length = 710 Score = 53.5 bits (127), Expect = 2e-07 Identities = 60/248 (24%), Positives = 94/248 (37%), Gaps = 20/248 (8%) Query: 9 KQVEKNDDDQKIEQDG---------IKPEDKAHKAATKIQASFRGHITRKKLKGE--KKD 57 K+VE++ +D+++ +D + P+ K KAA T+K KK Sbjct: 22 KEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKA 81 Query: 58 DV---QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE--PGKAGETPSEEK 112 V + A A KK P +G T +A AT K P K + K Sbjct: 82 AVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAK 141 Query: 113 KGEGDAATEQAAPQAPASSE-EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 171 K + D + + + E E E E A + +P+S+ ED E+ + D Sbjct: 142 KEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDD 201 Query: 172 A---AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKE 228 + A TTPA AAK E EE+ E D+ ++ D+ + Sbjct: 202 EEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDD 261 Query: 229 EEPEADQE 236 EE E ++E Sbjct: 262 EEEEEEEE 269 Score = 31.2 bits (69), Expect = 0.82 Identities = 36/159 (22%), Positives = 55/159 (34%), Gaps = 20/159 (12%) Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGE----GTTTAEAAPATGSKPDEPG-- 102 K K KK+D E + +++DE D E + E A AAPA+ + DE Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDED 194 Query: 103 --------------KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 148 +A ET + K +A A EE+ E + + Sbjct: 195 DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE 254 Query: 149 DNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187 D+ E+ +EE + P A AA +A Sbjct: 255 DDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEA 293 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 53.1 bits (126), Expect = 2e-07 Identities = 44/197 (22%), Positives = 74/197 (37%), Gaps = 15/197 (7%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA----GET 107 +GE + + + E E ++ E +G E++GEG E G +E G+ GE Sbjct: 890 EGEGEGEEEEGEGEGEEEGEG---EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946 Query: 108 PSEEKKGEGDAATEQAA----PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE 163 EE++GE + E+ + EE G E E + + E+ E Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006 Query: 164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVDETKPKE 219 E + + E+ + + E GE + EEN +E + +E Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066 Query: 220 SARQDEGKEEEPEADQE 236 Q+ G+EE D E Sbjct: 1067 GKYQETGEEENERQDGE 1083 Score = 52.0 bits (123), Expect = 5e-07 Identities = 52/237 (21%), Positives = 88/237 (37%), Gaps = 24/237 (10%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN- 67 ++ E+ + + K E +G + E + K + + R K+ KGE++ D E E Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG---KEEKGEEEGDQGEGEEEETE 802 Query: 68 -----KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQ 122 K++ V G ++G+G E G + + G+ E EE++GEG E Sbjct: 803 GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG 862 Query: 123 AAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTP 182 + EE G E E + E+ E ++ + Sbjct: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE------------G 910 Query: 183 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD---EGKEEEPEADQE 236 E+ + + E GE EE E E E ++ EG+EEE E + E Sbjct: 911 EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967 Score = 50.4 bits (119), Expect = 1e-06 Identities = 55/241 (22%), Positives = 90/241 (37%), Gaps = 22/241 (9%) Query: 5 MRRTKQVEKN--DDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAA 62 M R + EK + ++ ++DG + E K + +GH + + E+ + + Sbjct: 686 MERPGEGEKELAEKEEWKKRDGEEQEQKERE---------QGHQKERNQEMEEGGEEEHG 736 Query: 63 EAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPG--KAGETPSEEKKG--EGDA 118 E E + D + EK+GEG E G + E G K E +E+KG EGD Sbjct: 737 EGEEEEGDRE---EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793 Query: 119 ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 178 E + EEK E E + E+ +EE + + Sbjct: 794 G-EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE 852 Query: 179 ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGK---EEEPEADQ 235 E+ + + E GE EE E E + + ++EG+ EEE E + Sbjct: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912 Query: 236 E 236 E Sbjct: 913 E 913 Score = 50.1 bits (118), Expect = 2e-06 Identities = 48/240 (20%), Positives = 90/240 (37%), Gaps = 12/240 (5%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 ++ E+ + ++ E +G + E + + + + G + +GE+ + E + Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886 Query: 69 KDEAPVADGVEKKGEGTTTAEA-----APATGSKPDEPGKAGETPSEEKKGEG---DAAT 120 +E +G E++GEG E K +E G+ GE EE++GEG D Sbjct: 887 GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946 Query: 121 EQAAPQAPASSEEKAGSAETESATKASTD----NSPSSKAEDAPAKEEPKQADVPAAVTA 176 E + EE+ G E E + + + E +EE ++ Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006 Query: 177 AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 236 E+ + + E GE EE E E + KE ++ + E E ++E Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066 Score = 35.8 bits (81), Expect = 0.033 Identities = 32/155 (20%), Positives = 60/155 (38%), Gaps = 16/155 (10%) Query: 21 EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEK 80 E++G + + + + G + +GE++ + + E E ++E +G E+ Sbjct: 934 EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993 Query: 81 KGE--------GTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSE 132 +GE G E G + +E GE EE +GEG E+ + Sbjct: 994 EGEEEGEEEGEG---EEEGEGEGEEEEEGEVEGEVEGEEGEGEG----EEEEGEEEGEER 1046 Query: 133 EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 167 EK G E E+ + K ++ +E +Q Sbjct: 1047 EKEGEGE-ENRRNREEEEEEEGKYQETGEEENERQ 1080 >gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] Length = 825 Score = 53.1 bits (126), Expect = 2e-07 Identities = 53/195 (27%), Positives = 82/195 (42%), Gaps = 19/195 (9%) Query: 25 IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEG 84 + E A +A ++Q+ T ++ E +Q A DE P A+ E Sbjct: 495 LSEETSAEEAHAEVQSPLAEETTAEEASAE----IQLLAAIEAPADETP-AEAQSPLSE- 548 Query: 85 TTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESA 143 T+AE APA P G + E P E + G+ T +EE + + + +A Sbjct: 549 ETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETT----------AEEASAAIQLLAA 598 Query: 144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKATAQPPTETGES 202 T+AS + +P+ + + PA+E P + P A A A P AE+A A+ P E Sbjct: 599 TEASAEEAPA-EVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAE 657 Query: 203 SQAEENIEAVDETKP 217 Q EA E +P Sbjct: 658 VQPPPAEEAPAEVQP 672 Score = 51.6 bits (122), Expect = 6e-07 Identities = 53/192 (27%), Positives = 86/192 (44%), Gaps = 18/192 (9%) Query: 54 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPA-------TGSKPDEPGKAGE 106 E+ ++Q + A +EAP E TTAE A A T DE Sbjct: 435 EEARELQLSTAMETPAEEAPTEFQSPLPKE--TTAEEASAEIQLLAATEPPADETPAEAR 492 Query: 107 TPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE--SATKASTDNSPSSKAEDAPAKEE 164 +P E+ +A E +P A ++ E+A SAE + +A +A D +P+ +P EE Sbjct: 493 SPLSEETSAEEAHAEVQSPLAEETTAEEA-SAEIQLLAAIEAPADETPAE--AQSPLSEE 549 Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 224 + PA V + +A + E+A + QPP +GE + AEE A+ E++ ++ Sbjct: 550 TSAEEAPAEVQSPSAKGVSIEEAPLE--LQPP--SGEETTAEEASAAIQLLAATEASAEE 605 Query: 225 EGKEEEPEADQE 236 E +P +E Sbjct: 606 APAEVQPPPAEE 617 Score = 46.6 bits (109), Expect = 2e-05 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 12/226 (5%) Query: 22 QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV--QAAEAEANKKDEAPVADGVE 79 Q + E A +A+ +IQ + E + + + + EA+ + ++P+A+ Sbjct: 458 QSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETT 517 Query: 80 KKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAG--- 136 + E + + A + DE ++P E+ +A E +P A S E+A Sbjct: 518 AE-EASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL 576 Query: 137 ---SAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKAT 192 S E +A +AS + A +A A+E P + P A A A P AE+A A+ Sbjct: 577 QPPSGEETTAEEASAAIQLLA-ATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 635 Query: 193 AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238 P E Q EA E +P A + + + P A++ A Sbjct: 636 PPPAEEAPAEVQPPPAEEAPAEVQP-PPAEEAPAEVQPPPAEEAPA 680 Score = 39.7 bits (91), Expect = 0.002 Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 9/133 (6%) Query: 92 PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNS 151 PA G+ + P K EE + + AP+ E+A + +A + + + Sbjct: 400 PAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPR------EEARELQLSTAMETPAEEA 453 Query: 152 PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTET-GESSQAEENIE 210 P+ +P +E + A + AAT P A++ A+A + ET E + AE Sbjct: 454 PTE--FQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSP 511 Query: 211 AVDETKPKESARQ 223 +ET +E++ + Sbjct: 512 LAEETTAEEASAE 524 Score = 33.5 bits (75), Expect = 0.17 Identities = 56/250 (22%), Positives = 95/250 (38%), Gaps = 38/250 (15%) Query: 19 KIEQDGIKPEDKAHKAATKIQAS----FRGHITRKKLKGEKKDDVQAAEAEANKKDEAPV 74 K ++D +K HK++ KI AS F+ + G+K + E K + Sbjct: 176 KSKEDALK-----HKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLL 230 Query: 75 ADGVEKKGEGTTTAE--AAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS-- 130 D + ++ E A S EP + P++ + + AT +A P+ PA Sbjct: 231 EDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPR-PAEET 289 Query: 131 ------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA------AA 178 S E+ AE +A ++ AE+AP E P + P+A + A Sbjct: 290 HVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAE 349 Query: 179 ATTPAAEDAAAK----ATAQPPTETGESSQAEENIEAVDETK--------PKESARQDEG 226 P+AE++ ++ PP E S + I + K P E A ++ Sbjct: 350 ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAP 409 Query: 227 KEEEPEADQE 236 + EP +E Sbjct: 410 AKVEPPTVEE 419 >gi|42518068 trans-golgi network protein 2 [Homo sapiens] Length = 437 Score = 52.8 bits (125), Expect = 3e-07 Identities = 50/209 (23%), Positives = 81/209 (38%), Gaps = 28/209 (13%) Query: 56 KDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGE 115 KD + AEA +++P G E K + + +++ + D P K+G K G Sbjct: 134 KDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGS 193 Query: 116 GDAATEQAAP-----------QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-- 162 + E P Q P K+G+ E S + ++D+P K Sbjct: 194 SKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVV 253 Query: 163 -EEPKQAD--VPAAVTAAAATTPAAE--DAAAKATAQP---PTETGES----SQAEENI- 209 E+P + D P + + P A+ A K P TE+GE S +E + Sbjct: 254 PEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVK 313 Query: 210 --EAVDETKPKESARQDEGKEEEPEADQE 236 E ++ +PKE+ D G EE +E Sbjct: 314 SSEPTEDVEPKEAEDDDTGPEEGSPPKEE 342 Score = 46.2 bits (108), Expect = 2e-05 Identities = 62/262 (23%), Positives = 102/262 (38%), Gaps = 55/262 (20%) Query: 19 KIEQDGIKPEDKAHKAATKIQASFR-GHITRKKLKGEK-KDDVQAAEAEANKKDEAPVAD 76 K E+ G++P A +T S R G T+ + + KD + AEA ++ P Sbjct: 27 KQEEAGVRPS--AGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKS 84 Query: 77 GVEKKGE---------------GTT-------------TAEAAPATGSKPDEPGKAG--- 105 G E K + G+T T+++ P + D GK+G Sbjct: 85 GAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEA 144 Query: 106 ETPSEEKKGEG-DAATEQAAPQAPASSEEKAGSAETESATKAST--DNSPSSKAEDAPAK 162 +TP + G +A T++ +P S + +S T D S S AED K Sbjct: 145 QTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPK 204 Query: 163 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKES 220 + P + + A TP + A Q P + S AEE ++ ++ P++ Sbjct: 205 DVPNK-------SGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQP 257 Query: 221 ARQDEGK--------EEEPEAD 234 +R+D K +E P+AD Sbjct: 258 SRKDHSKPISNPSDNKELPKAD 279 Score = 32.3 bits (72), Expect = 0.37 Identities = 27/145 (18%), Positives = 56/145 (38%), Gaps = 11/145 (7%) Query: 88 AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS 147 A A P ++ + +AG PS G+ +T P+ S+ GS ++ + Sbjct: 15 AGAVPLLATESVKQEEAGVRPSA-----GNVSTH------PSLSQRPGGSTKSHPEPQTP 63 Query: 148 TDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE 207 D+ S AE ++ P ++ A ++ AE K + ++++ Sbjct: 64 KDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDST 123 Query: 208 NIEAVDETKPKESARQDEGKEEEPE 232 + + PK+S + + + PE Sbjct: 124 SKSHPELQTPKDSTGKSGAEAQTPE 148 >gi|117938759 GNAS complex locus XLas [Homo sapiens] Length = 1037 Score = 52.4 bits (124), Expect = 3e-07 Identities = 61/213 (28%), Positives = 76/213 (35%), Gaps = 15/213 (7%) Query: 14 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAP 73 N D I DG P K A K + + R + + + E D AE K Sbjct: 324 NMDSPPIALDG--PPIKVSGAPDKRERAERPPVEEEAAEMEGAADA----AEGGKVPSPG 377 Query: 74 VADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA-PASSE 132 T A AAPA + PD +G TP + G A + A A P S Sbjct: 378 YGSPAAGAASADTAARAAPAAPADPD----SGATPEDPDSGTAPADPDSGAFAADPDSGA 433 Query: 133 EKAGSAETESATKASTDNSPSS-KAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAK 190 A A+ +S P S A DAPA +P P A A AAA T AA A A Sbjct: 434 APAAPADPDSGAAPDAPADPDSGAAPDAPA--DPDAGAAPEAPAAPAAAETRAAHVAPAA 491 Query: 191 ATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 A PT S+ + P AR+ Sbjct: 492 PDAGAPTAPAASATRAAQVRRAASAAPASGARR 524 Score = 44.3 bits (103), Expect = 9e-05 Identities = 46/178 (25%), Positives = 67/178 (37%), Gaps = 27/178 (15%) Query: 53 GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 112 G +D + A A+ A AD A A P +G+ PD P + + Sbjct: 405 GATPEDPDSGTAPADPDSGAFAAD---PDSGAAPAAPADPDSGAAPDAPADPDSGAAPDA 461 Query: 113 KGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA 172 + DA AP APA++E +A +P + A APA + A V Sbjct: 462 PADPDAGAAPEAPAAPAAAETRAAHV---------APAAPDAGAPTAPAASATRAAQVRR 512 Query: 173 AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES-ARQDEGKEE 229 A +AA A+ A K +PP+ I+A D P+ + A GK E Sbjct: 513 AASAAPAS-----GARRKIHLRPPS---------PEIQAADPPTPRPTRASAWRGKSE 556 Score = 37.0 bits (84), Expect = 0.015 Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 9/139 (6%) Query: 98 PDEPGKAGETPSEEKKGEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSPSS 154 PD+ +A P EE+ E + A + A +P AG+A ++A +A+ + + Sbjct: 343 PDKRERAERPPVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAP--AAPA 400 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 + E+P PA + A AA A A P + + A+ + A Sbjct: 401 DPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAA-- 458 Query: 215 TKPKESARQDEGKEEEPEA 233 P A D G E A Sbjct: 459 --PDAPADPDAGAAPEAPA 475 Score = 36.6 bits (83), Expect = 0.020 Identities = 41/156 (26%), Positives = 55/156 (35%), Gaps = 11/156 (7%) Query: 89 EAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 148 EAA G+ G +P G A+ + AA APA+ + A E + Sbjct: 357 EAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTA 416 Query: 149 DNSPSSKAEDAPAKEEPKQADVPAAV----TAAAATTPAAEDAAAKATAQPPTETGESSQ 204 P S A A +P PAA + AA PA D+ A A + G + + Sbjct: 417 PADPDSGAFAA----DPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPE 472 Query: 205 AEENIEAVDETKPKE--SARQDEGKEEEPEADQEHA 238 A A ET+ A D G P A A Sbjct: 473 APA-APAAAETRAAHVAPAAPDAGAPTAPAASATRA 507 >gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] Length = 3664 Score = 51.6 bits (122), Expect = 6e-07 Identities = 55/202 (27%), Positives = 82/202 (40%), Gaps = 21/202 (10%) Query: 46 ITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAG 105 +TR + K EK+ D + E E + E + + P+ G Sbjct: 1590 LTRMQQK-EKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLE 1648 Query: 106 ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 165 PS +K GD E AP +EEK E AT S + P+S+ AP E+ Sbjct: 1649 SAPSALEKTTGDKTVE-----APLVTEEKT----VEPAT-VSEEAKPASEPAPAPV-EQL 1697 Query: 166 KQADVP--------AAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE-AVDETK 216 +Q D+P AA+ A ++ D A+PPT SQAE N++ D T+ Sbjct: 1698 EQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQ 1757 Query: 217 PKESARQDEGKEEEPEADQEHA 238 P Q + EP+A++ A Sbjct: 1758 PLSKPAQKSEEANEPKAEKPDA 1779 Score = 45.1 bits (105), Expect = 6e-05 Identities = 47/213 (22%), Positives = 84/213 (39%), Gaps = 13/213 (6%) Query: 28 EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAE-AEANKKDEAPVADGVEKKGEGTT 86 E + +AA RG + + + +++++ +A E AE K E + +K Sbjct: 1935 ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK------ 1988 Query: 87 TAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKA 146 TA G K K T E G + + P ++EE+AGS + A Sbjct: 1989 TAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA 2048 Query: 147 STDNSPSSKA-----EDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGE 201 TD +P A E PA E+ ++ + + A +A A P + Sbjct: 2049 GTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQ 2108 Query: 202 SSQAEENIEAVDETKPKESARQDEGKEEEPEAD 234 + + E + AV K ES ++++G + ++D Sbjct: 2109 AGERESGVVAVSPEK-SESPQKEDGLSSQLKSD 2140 Score = 42.4 bits (98), Expect = 4e-04 Identities = 47/210 (22%), Positives = 72/210 (34%), Gaps = 8/210 (3%) Query: 11 VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 70 +EK D+ +E + E A +A + E+ + V K+ Sbjct: 1654 LEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPV--EQLEQVDLPPGADPDKE 1711 Query: 71 EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130 A + GVE+ G + P +KP PG + E D+ T+ + A S Sbjct: 1712 AAMMPAGVEEGSSG----DQPPYLDAKPPTPGASFSQAESNVDPEPDS-TQPLSKPAQKS 1766 Query: 131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAK 190 E AE AT A + + KAE AP + P D+ AA + +K Sbjct: 1767 EEANEPKAEKPDAT-ADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSK 1825 Query: 191 ATAQPPTETGESSQAEENIEAVDETKPKES 220 Q + E +D K K S Sbjct: 1826 TPVQAAAVSIVEKPVTRKSERIDREKLKRS 1855 Score = 41.6 bits (96), Expect = 6e-04 Identities = 47/193 (24%), Positives = 72/193 (37%), Gaps = 17/193 (8%) Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108 +K KG +K + NKK APV V + + + AA G+ P E P Sbjct: 2327 RKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANE-GTTVQHP----EAP 2381 Query: 109 SEEKKGEGDAATEQAA--------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 160 EEK+ E +T + P SS+E S E + TKAS + AP Sbjct: 2382 QEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEI--SVEERTPTKASVPPDLPPPPQPAP 2439 Query: 161 AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220 EEP+ ++ + TP ++ + T P+ T + P Sbjct: 2440 VDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL--PSVTAAKLSPPVASGGIPHQSPPTK 2497 Query: 221 ARQDEGKEEEPEA 233 + ++EEP A Sbjct: 2498 VTEWITRQEEPRA 2510 Score = 32.0 bits (71), Expect = 0.48 Identities = 39/178 (21%), Positives = 61/178 (34%), Gaps = 15/178 (8%) Query: 60 QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 119 + A A+A +++ VA EK + S P +P K E G A Sbjct: 2103 RGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEA 2162 Query: 120 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAA 179 T+ A + E SA+ A ++P A + + K A + AAA Sbjct: 2163 TQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPE----DRDKPAHQASETELAAA 2218 Query: 180 TTPAAEDAAAKAT--AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235 D + + PP GES + +P A+ + EE E D+ Sbjct: 2219 IGSIINDISGEPENFPAPPPYPGESQ---------TDLQPPAGAQALQPSEEGMETDE 2267 Score = 29.6 bits (65), Expect = 2.4 Identities = 17/42 (40%), Positives = 18/42 (42%) Query: 152 PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATA 193 P+SKA P KE K D AA T A P A A A Sbjct: 3221 PASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPA 3262 Score = 28.5 bits (62), Expect = 5.3 Identities = 17/85 (20%), Positives = 35/85 (41%) Query: 95 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 154 G +P+ + + S + + ++ A QA + +GS ++ + + +S SS Sbjct: 230 GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAA 179 + D+ D PA +AA Sbjct: 290 TSSDSSDSSSSSSDDSPARSVQSAA 314 >gi|153945728 microtubule-associated protein 1B [Homo sapiens] Length = 2468 Score = 51.6 bits (122), Expect = 6e-07 Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 9/184 (4%) Query: 54 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE---PGKAGETPSE 110 EK + + EA +K+ E EG TT E P+E K G E Sbjct: 865 EKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIE 924 Query: 111 EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADV 170 + + EG E + EEKA + E E + ++ S ++ +P ++E Sbjct: 925 KFEDEGAGFEESSET---GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAE 981 Query: 171 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230 A + A+ D A+ E GE+ Q+EE DE E AR++E + E+ Sbjct: 982 ADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEE---ADEEDKAEDAREEEYEPEK 1038 Query: 231 PEAD 234 EA+ Sbjct: 1039 MEAE 1042 Score = 49.7 bits (117), Expect = 2e-06 Identities = 57/241 (23%), Positives = 95/241 (39%), Gaps = 26/241 (10%) Query: 9 KQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 K+ + +D+K E++ KP+ + K K ++++K E K +++ E + K Sbjct: 640 KETKVKPEDKKEEKE--KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697 Query: 69 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQA 127 K+ E K E E + EP K + P + KK ++T + + Sbjct: 698 KEVKKETPPKEVKKE--VKKEEKKEVKKEEKEPKKEIKKLPKDAKK----SSTPLSEAKK 751 Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 187 PA+ + K E + P K + K+E K A+ AA ATT A A Sbjct: 752 PAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAA 811 Query: 188 AAKATAQPP----------------TETGESSQAEENIEAVDETKPKESARQDEGKEEEP 231 A A P T+ E +AEE ++ + KP+ +DE K +E Sbjct: 812 AGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE-VDVTKDIKPQLELIEDEEKLKET 870 Query: 232 E 232 E Sbjct: 871 E 871 Score = 46.6 bits (109), Expect = 2e-05 Identities = 54/194 (27%), Positives = 84/194 (43%), Gaps = 21/194 (10%) Query: 57 DDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK---K 113 DD++ E E +E+ E+K E T AE G + + +P+E++ K Sbjct: 921 DDIEKFEDEGAGFEESSETGDYEEKAE-TEEAEEPEEDGEEHVCVSASKHSPTEDEESAK 979 Query: 114 GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS-----KAEDAPAKE-EPKQ 167 E DA + ++ AS +++A E+ K + S KAEDA +E EP++ Sbjct: 980 AEADAYIREKR-ESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEK 1038 Query: 168 A---DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAV-DETKPKES--- 220 D AV AA AE+ T P + G S E ++ DET P S Sbjct: 1039 MEAEDYVMAVVDKAAEAGGAEEQYGFLTT-PTKQLGAQSPGREPASSIHDETLPGGSESE 1097 Query: 221 --ARQDEGKEEEPE 232 A +E +E++PE Sbjct: 1098 ATASDEENREDQPE 1111 Score = 39.7 bits (91), Expect = 0.002 Identities = 56/253 (22%), Positives = 95/253 (37%), Gaps = 37/253 (14%) Query: 8 TKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 67 +K V K ++ E + +K K +K + + K +K E K V E + Sbjct: 554 SKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKD---KPIKTETKPSVTEKEVPS- 609 Query: 68 KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 127 K++ +PV V +K +AA K + K + E++K + + A ++ + Sbjct: 610 KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKE--DKT 667 Query: 128 PASSEEKAGSAETESATKASTDNSPSSKAE-----DAPAKE------------------E 164 P EEK E + K + + + P KE E Sbjct: 668 PIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKE 727 Query: 165 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR-- 222 PK+ A ++TP +E A A +P E S ++++ A KPKE + Sbjct: 728 PKKEIKKLPKDAKKSSTPLSE-AKKPAALKPKVPKKEESVKKDSVAA---GKPKEKGKIK 783 Query: 223 --QDEGKEEEPEA 233 + EGK E A Sbjct: 784 VIKKEGKAAEAVA 796 Score = 33.9 bits (76), Expect = 0.13 Identities = 37/191 (19%), Positives = 68/191 (35%), Gaps = 33/191 (17%) Query: 76 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE--QAAPQAPASSEE 133 DG G+ + + E S P+ G + ET ++ + D +T + A + + + Sbjct: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTP-DTSTYCYETAEKITRTPQA 2054 Query: 134 KAGSAETESATKASTDNSPSSKAEDAP-----------------------------AKEE 164 S ET + SPS +D A EE Sbjct: 2055 STYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEE 2114 Query: 165 P-KQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223 P ++++ P + A P + + PPT ES+ ++ + + ET+ S Sbjct: 2115 PTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITA 2174 Query: 224 DEGKEEEPEAD 234 D + E E++ Sbjct: 2175 DANIDSEDESE 2185 Score = 32.0 bits (71), Expect = 0.48 Identities = 31/125 (24%), Positives = 49/125 (39%), Gaps = 8/125 (6%) Query: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAA-PATGSKPDEPGKAGET 107 K LK + K+ + + K +PV KK +G + AA P + K Sbjct: 2233 KALKKDLKEKTKTKKPGTKTKSSSPV-----KKSDGKSKPLAASPKPAGLKESSDKVSRV 2287 Query: 108 PSEEKKGEGD-AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPK 166 S +KK + AA P+ A+ E+ ET++A AS S + + K Sbjct: 2288 ASPKKKESVEKAAKPTTTPEVKAARGEEKDK-ETKNAANASASKSAKTATAGPGTTKTTK 2346 Query: 167 QADVP 171 + VP Sbjct: 2347 SSAVP 2351 Score = 29.3 bits (64), Expect = 3.1 Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 18/120 (15%) Query: 25 IKPEDKAHKAATKIQASFRGHITRKKLK---------GEKKDDVQAAEAEANKKDEAPVA 75 +K + K K TK ++S + K K G K+ + + + KK E+ Sbjct: 2239 LKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKES--- 2295 Query: 76 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKA 135 VEK + TTT E A G + D+ K S K A T A P +++ A Sbjct: 2296 --VEKAAKPTTTPEVKAARGEEKDKETKNAANASASK----SAKTATAGPGTTKTTKSSA 2349 Score = 27.7 bits (60), Expect = 9.1 Identities = 30/138 (21%), Positives = 48/138 (34%), Gaps = 7/138 (5%) Query: 102 GKAGETP-----SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKA 156 G AG TP ++EK + P P S E E E A+ + D Sbjct: 1329 GSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSE 1388 Query: 157 EDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETK 216 P ++ +A + +A+D A+ A+ P E E S + + + V Sbjct: 1389 SPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFE--EKSGKQGSPDQVSPVS 1446 Query: 217 PKESARQDEGKEEEPEAD 234 S + K+E D Sbjct: 1447 EMTSTSLYQDKQEGKSTD 1464 >gi|104526627 triadin [Homo sapiens] Length = 729 Score = 51.6 bits (122), Expect = 6e-07 Identities = 56/248 (22%), Positives = 96/248 (38%), Gaps = 29/248 (11%) Query: 6 RRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAE 65 ++ EK + +K E + E K K A K + T+K++KG K++ V+ A+ Sbjct: 182 KKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEK-----TKKEVKGGKQEKVKQTAAK 236 Query: 66 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPG--------------KAGETPSEE 111 + + P K E +AA + + D+ K G++P+ Sbjct: 237 VKEVQKTP-----SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA-DV 170 TEQA+ PAS + E + A K T + + ED K E + A DV Sbjct: 292 PP----LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347 Query: 171 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 230 A+ T A A E E S+ + V++ K K+ ++++ E Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407 Query: 231 PEADQEHA 238 +EH+ Sbjct: 408 KSPKKEHS 415 Score = 47.4 bits (111), Expect = 1e-05 Identities = 51/206 (24%), Positives = 83/206 (40%), Gaps = 42/206 (20%) Query: 52 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 111 +GEKK + +E KK++ + ++KK E T + + EPGKA ET Sbjct: 313 EGEKKKAEKKVTSETKKKEK----EDIKKKSEKETAIDV------EKKEPGKASET---- 358 Query: 112 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAED------APAKEEP 165 K+G T + A QA A +EK +++ K + P K ++ PAK Sbjct: 359 KQG-----TVKIAAQAAAKKDEK--KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411 Query: 166 KQADVPAAVTAAAATTPAAEDAAAKA---------------TAQPPTETGESSQAEENIE 210 K+ VP+ A T A E+ A + T + +S + ++ Sbjct: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471 Query: 211 AVDETKPKESARQDEGKEEEPEADQE 236 + K KE KE+EPE ++ Sbjct: 472 DKEPIKGKEEKVPASLKEKEPETKKD 497 Score = 29.6 bits (65), Expect = 2.4 Identities = 42/177 (23%), Positives = 70/177 (39%), Gaps = 27/177 (15%) Query: 17 DQKIEQDG--IKPED------KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 68 D+K+ + G +KP+ K K +I+ + I+ +K++ K+D V+ + ++ Sbjct: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAIS-EKVQIHKQDIVKPEKTVSHG 555 Query: 69 KDEAPV-----ADGVEKKGEGTTTAEAA---------PATGSKPDEPGKAGETPSEEKKG 114 K E V A +EK + T +A KP G + T S +KK Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615 Query: 115 EGDAATEQAAPQAPASSEEKAG----SAETESATKASTDNSPSSKAEDAPAKEEPKQ 167 E + EEK S + + TKA S ED PA ++ K+ Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672 >gi|13540523 nucleosomal binding protein 1 [Homo sapiens] Length = 282 Score = 49.7 bits (117), Expect = 2e-06 Identities = 49/208 (23%), Positives = 83/208 (39%), Gaps = 35/208 (16%) Query: 28 EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK--KDEAPVADGVEKKGEGT 85 ED K K +A ++ + E ++D + EA K KDE DG E K G Sbjct: 106 EDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKN-GN 164 Query: 86 TTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATK 145 E A K E GK GE + KG G+ E+ + ++ G + K Sbjct: 165 EKGEDA-----KEKEDGKKGE----DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGK 215 Query: 146 ASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQA 205 D + +D KE+ K+ + ED E+ + Sbjct: 216 EKGDKK---EGKDVKVKEDEKERE------------DGKEDEGGNEE--------EAGKE 252 Query: 206 EENIEAVDETKPKESARQDEGKEEEPEA 233 +E+++ +E K ++ ++D+GK+EEP++ Sbjct: 253 KEDLKEEEEGKEEDEIKEDDGKKEEPQS 280 >gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa [Homo sapiens] Length = 517 Score = 49.7 bits (117), Expect = 2e-06 Identities = 57/254 (22%), Positives = 106/254 (41%), Gaps = 34/254 (13%) Query: 6 RRTKQVEKNDDDQKIEQDGIKP---------EDKAHKAATKIQASFR--GHITRKKLK-- 52 RR K ++++D+++ E+ G + ED ++ AS G + + K K Sbjct: 180 RRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAP 239 Query: 53 ----GEKKDDVQAAEAEANKKDEAPVADG--VEKKGEGTTTAEAAPATGSKP-------- 98 G KK + ++ EA + + +G V+ +G+++++ P + +K Sbjct: 240 LAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPK 299 Query: 99 --DEPGKAGETPSEEKKGEGDAATEQ--AAPQAPASSEEKAGSAETESATKASTDNSPSS 154 DE + E EEK E D E+ AP K S E++S+ ++ D+ SS Sbjct: 300 GVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASS 359 Query: 155 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 A K PK+ P+ ++ + P A +T+ T +S+ E+ + V E Sbjct: 360 ALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSS--TLRAAASKLEQG-KRVSE 416 Query: 215 TKPKESARQDEGKE 228 + R D G + Sbjct: 417 MPAAKRLRLDTGPQ 430 Score = 39.7 bits (91), Expect = 0.002 Identities = 35/196 (17%), Positives = 78/196 (39%), Gaps = 25/196 (12%) Query: 48 RKKLKGEKKDDVQAAEAEANKKDEAPVA-----DGVEKKGEGTTTA--EAAPATGSKPDE 100 +++LK + +D+ + + + ++ + + D +E + + + E +K Sbjct: 179 QRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKA 238 Query: 101 PGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 160 P G ++KKG D A E + + + + S +S+ P SKA+ Sbjct: 239 PLAKGGRKKKKKKGSDDEAFEDSD-----DGDFEGQEVDYMSDGSSSSQEEPESKAKAPQ 293 Query: 161 AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 220 +E PK D + D++ ++ + P E + + E+ E K ++ Sbjct: 294 QEEGPKGVDEQS-------------DSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKD 340 Query: 221 ARQDEGKEEEPEADQE 236 + ++ EE + D E Sbjct: 341 SSEESDSSEESDIDSE 356 Score = 38.9 bits (89), Expect = 0.004 Identities = 42/177 (23%), Positives = 79/177 (44%), Gaps = 30/177 (16%) Query: 62 AEAEANKKDEAPVADGVEKKGEGTTTAEAA-PATGSKPDEPGKAGETPSEEKK------- 113 ++A+A +++E P GV+++ + + +E P K +E K TP E+K+ Sbjct: 287 SKAKAPQQEEGP--KGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEE 344 Query: 114 ----------GEGDAATEQAAPQAPASSEEK--AGSAETES--ATKASTDNSPSSKAEDA 159 E +A A + P E K GS+ S T ++ S SS A Sbjct: 345 SDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAA 404 Query: 160 PAKEE--PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 214 +K E + +++PAA T P + + K+T QPP +G+++ +++ ++ Sbjct: 405 ASKLEQGKRVSEMPAAKRLRLDTGP--QSLSGKSTPQPP--SGKTTPNSGDVQVTED 457 >gi|7662162 ALEX2 protein [Homo sapiens] Length = 632 Score = 48.9 bits (115), Expect = 4e-06 Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%) Query: 26 KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 82 KP+++A + +A R T G AEAE +DEA D G E Sbjct: 40 KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99 Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 123 ++AEA GS+ E AG P E G +A Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159 Query: 124 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 168 AP +AP +E + TE+A P +K +AP P +A Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219 Query: 169 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 211 VPA T AAA T AAE AA KAT P TG +A A Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277 Query: 212 VDETKPKESAR-----QDEGKEEEPEADQ 235 V + K R + +GK+ + E D+ Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306 Score = 34.3 bits (77), Expect = 0.097 Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%) Query: 85 TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 138 T AEA PAT + P A E+P G +A ++A P A + KA SA Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274 Query: 139 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 193 + K T + K + +K E + + AAAA +A A Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334 Query: 194 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 231 P +E GES + E + ++ ET+ + R+ ++ P Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374 >gi|29540562 ALEX2 protein [Homo sapiens] Length = 632 Score = 48.9 bits (115), Expect = 4e-06 Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%) Query: 26 KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 82 KP+++A + +A R T G AEAE +DEA D G E Sbjct: 40 KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99 Query: 83 EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 123 ++AEA GS+ E AG P E G +A Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159 Query: 124 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 168 AP +AP +E + TE+A P +K +AP P +A Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219 Query: 169 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 211 VPA T AAA T AAE AA KAT P TG +A A Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277 Query: 212 VDETKPKESAR-----QDEGKEEEPEADQ 235 V + K R + +GK+ + E D+ Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306 Score = 34.3 bits (77), Expect = 0.097 Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%) Query: 85 TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 138 T AEA PAT + P A E+P G +A ++A P A + KA SA Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274 Query: 139 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 193 + K T + K + +K E + + AAAA +A A Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334 Query: 194 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 231 P +E GES + E + ++ ET+ + R+ ++ P Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374 >gi|78042577 MAP7 domain containing 1 [Homo sapiens] Length = 841 Score = 48.9 bits (115), Expect = 4e-06 Identities = 56/241 (23%), Positives = 94/241 (39%), Gaps = 28/241 (11%) Query: 18 QKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEA-EANKKDEA-PVA 75 QK E+ + E++ K+A + S + R+ L + + A+ A E + K +A P + Sbjct: 413 QKKEKKDKERENEKEKSALARERSLK---KRQSLPASPRARLSASTASELSPKSKARPSS 469 Query: 76 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE----KKGEGDAATEQAAPQAPASS 131 + P P P G T S + +K E + A P+ + S Sbjct: 470 PSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQS 529 Query: 132 EEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAA------- 184 + +A S E ESA AS SP+ AP ++E A+ P AA T+P A Sbjct: 530 KRRA-SNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETP--TDAAVLTSPPAPAPPVTP 586 Query: 185 ---------EDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 235 + A + A+ + E + EE + + K + +E E A++ Sbjct: 587 SKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAER 646 Query: 236 E 236 E Sbjct: 647 E 647 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.294 0.113 0.293 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,070,716 Number of Sequences: 37866 Number of extensions: 520723 Number of successful extensions: 9483 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 528 Number of HSP's successfully gapped in prelim test: 1193 Number of HSP's that attempted gapping in prelim test: 4386 Number of HSP's gapped (non-prelim): 4487 length of query: 238 length of database: 18,247,518 effective HSP length: 99 effective length of query: 139 effective length of database: 14,498,784 effective search space: 2015330976 effective search space used: 2015330976 T: 11 A: 40 X1: 17 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 44 (21.8 bits) S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.