Search of human proteins with 4503833

Search of human proteins with 4503833

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503833 frizzled 7 [Homo sapiens]
         (574 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503833 frizzled 7 [Homo sapiens]                                 1203   0.0  
gi|4503827 frizzled 2 [Homo sapiens]                                  926   0.0  
gi|4503825 frizzled 1 [Homo sapiens]                                  919   0.0  
gi|27894385 frizzled 5 precursor [Homo sapiens]                       535   e-152
gi|13994190 frizzled 8 [Homo sapiens]                                 504   e-143
gi|6005762 frizzled 10 [Homo sapiens]                                 493   e-139
gi|8393378 frizzled 3 [Homo sapiens]                                  484   e-137
gi|4503835 frizzled 9 [Homo sapiens]                                  459   e-129
gi|34734079 frizzled 6 [Homo sapiens]                                 458   e-129
gi|22547161 frizzled 4 [Homo sapiens]                                 439   e-123
gi|5032099 smoothened [Homo sapiens]                                  182   9e-46
gi|38455388 frizzled-related protein [Homo sapiens]                   130   3e-30
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]      119   6e-27
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]       110   3e-24
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]        105   1e-22
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...   103   6e-22
gi|29244926 corin [Homo sapiens]                                       97   5e-20
gi|13899255 membrane frizzled-related protein [Homo sapiens]           76   7e-14
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                67   3e-11
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      66   8e-11
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    52   2e-06
gi|45433552 G protein-coupled receptor 133 [Homo sapiens]              35   0.24 
gi|93204873 G protein-coupled receptor 157 [Homo sapiens]              35   0.24 
gi|73476377 LBXCOR1 homolog [Homo sapiens]                             33   0.54 
gi|7662494 Kruppel-like factor 15 [Homo sapiens]                       33   0.54 
gi|7019387 G protein-coupled receptor 132 [Homo sapiens]               33   0.93 
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...    32   2.1  
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [...    32   2.1  
gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens]    32   2.1  
gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo sapi...    32   2.1  

>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score = 1203 bits (3113), Expect = 0.0
 Identities = 574/574 (100%), Positives = 574/574 (100%)

Query: 1   MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI 60
           MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI
Sbjct: 1   MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI 60

Query: 61  AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC 120
           AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC
Sbjct: 61  AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC 120

Query: 121 RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYP 180
           RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYP
Sbjct: 121 RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYP 180

Query: 181 TAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRAN 240
           TAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRAN
Sbjct: 181 TAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRAN 240

Query: 241 GLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA 300
           GLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
Sbjct: 241 GLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA 300

Query: 301 VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLT 360
           VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLT
Sbjct: 301 VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLT 360

Query: 361 WFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDA 420
           WFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDA
Sbjct: 361 WFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDA 420

Query: 421 LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTV 480
           LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTV
Sbjct: 421 LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTV 480

Query: 481 PATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIV 540
           PATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIV
Sbjct: 481 PATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIV 540

Query: 541 GITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV 574
           GITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
Sbjct: 541 GITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV 574


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  926 bits (2392), Expect = 0.0
 Identities = 448/572 (78%), Positives = 487/572 (85%), Gaps = 15/572 (2%)

Query: 9   PLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILP 68
           P S+L    L L LL A    AG   +HGEKGIS+PDHGFCQPISIPLCTDIAYNQTI+P
Sbjct: 3   PRSALPRLLLPLLLLPA----AGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMP 58

Query: 69  NLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERAR 128
           NLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVL+QAIPPCRS+CERAR
Sbjct: 59  NLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERAR 118

Query: 129 QGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDL 188
           QGCEALMNKFGFQWPERLRCE+FP HGA +ICVGQN S+      G P    TAP     
Sbjct: 119 QGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSED-----GAPALLTTAPPPGLQ 173

Query: 189 PFTALPPGASDGRGRPA------FPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGL 242
           P     PG   G G P        PF CPR LKVP YL Y+FLGERDC APCEP R +G 
Sbjct: 174 PGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGS 233

Query: 243 MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVA 302
           M+F +EE RFARLW+  WSVLCCAST FTV TYLVDM+RF YPERPIIFLSGCY MV+VA
Sbjct: 234 MFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVA 293

Query: 303 HVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWF 362
           ++AGF+L++R VC ERFS+DGYRTV QGTKKEGCTILFM+LYFF MASSIWWVILSLTWF
Sbjct: 294 YIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWF 353

Query: 363 LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALR 422
           LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQ+DGDLLSGVC+VGL+S+D LR
Sbjct: 354 LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLR 413

Query: 423 GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPA 482
           GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLE+LMVRIGVFSVLYTVPA
Sbjct: 414 GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPA 473

Query: 483 TIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGI 542
           TIV+ACYFYEQAFREHWER+W+ Q CKS A+PCP  + P MSPDFTV+MIKYLMT+IVGI
Sbjct: 474 TIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGI 533

Query: 543 TTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV 574
           T+GFWIWSGKTL SWR+FY RL++S  GET V
Sbjct: 534 TSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV 565


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  919 bits (2375), Expect = 0.0
 Identities = 443/560 (79%), Positives = 484/560 (86%), Gaps = 30/560 (5%)

Query: 33  QPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKV 92
           Q Y+GE+GISVPDHG+CQPISIPLCTDIAYNQTI+PNLLGHTNQEDAGLEVHQFYPLVKV
Sbjct: 100 QQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKV 159

Query: 93  QCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFP 152
           QCS EL+FFLCSMYAPVCTVL+QA+PPCRSLCERARQGCEALMNKFGFQWP+ L+CE FP
Sbjct: 160 QCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFP 219

Query: 153 VHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFP----- 207
           VHGAGE+CVGQNTSD            PT   LP+  F    P    G  R  FP     
Sbjct: 220 VHGAGELCVGQNTSD---------KGTPTPSLLPE--FWTSNPQHGGGGHRGGFPGGAGA 268

Query: 208 -----FSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSV 262
                FSCPR LKVP YL Y FLGE+DCGAPCEP +  GLMYF  EE RF+R W+G+WSV
Sbjct: 269 SERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSV 328

Query: 263 LCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDD 322
           LCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCY  VAVA++AGFLLEDR VC ++F++D
Sbjct: 329 LCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAED 388

Query: 323 GYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFH 382
           G RTVAQGTKKEGCTILFM+LYFF MASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFH
Sbjct: 389 GARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFH 448

Query: 383 LAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLA 442
           LAAWAVPA+KTITILA+GQVDGD+LSGVC+VGL++VDALRGFVLAPLFVYLFIGTSFLLA
Sbjct: 449 LAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLA 508

Query: 443 GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERT 502
           GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIV+ACYFYEQAFR+ WER+
Sbjct: 509 GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERS 568

Query: 503 WLLQTCKSYAVPCP--------PGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTL 554
           W+ Q+CKSYA+PCP        P H PPMSPDFTVFMIKYLMT+IVGIT+GFWIWSGKTL
Sbjct: 569 WVAQSCKSYAIPCPHLQAGGGAPPH-PPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTL 627

Query: 555 QSWRRFYHRLSHSSKGETAV 574
            SWR+FY RL++S +GET V
Sbjct: 628 NSWRKFYTRLTNSKQGETTV 647


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  535 bits (1379), Expect = e-152
 Identities = 286/581 (49%), Positives = 366/581 (62%), Gaps = 63/581 (10%)

Query: 1   MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI 60
           M  P  +AP S   L  L+LA L   +A A   P              CQ I++P+C  I
Sbjct: 1   MARPDPSAPPS---LLLLLLAQLVGRAAAASKAPV-------------CQEITVPMCRGI 44

Query: 61  AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPP 119
            YN T +PN   H  Q++AGLEVHQF+PLV++QCSP+LRFFLCSMY P+C     + +PP
Sbjct: 45  GYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPP 104

Query: 120 CRSLCERARQGCEALMNKFGFQWPERLRCENFPVHG--AGEICVGQNTSDGSGGPGGGPT 177
           CRS+CERA+ GC  LM ++GF WPER+ C+  PV G  A  +C+  N S+ +  P   P 
Sbjct: 105 CRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAP---PR 161

Query: 178 AYPTAPYLPDLPFTALPPGA--SDGRGRPAFPFSCPRQLKVPP--------YLGYRFLGE 227
            +P  P LP       PPGA  S G      PF C  +    P        Y   R    
Sbjct: 162 PFPAKPTLPG------PPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQV 215

Query: 228 RDCGAPC-EPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPE 286
            +C  PC +P        F  +ER FA  W+G+WSVLC  ST  TV T+L+DM RF YPE
Sbjct: 216 PNCAVPCYQPS-------FSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPE 268

Query: 287 RPIIFLSGCYFMVAVAHVAGFLLEDRAV-CVERFSDDGYRTVAQGTKKEGCTILFMVLYF 345
           RPIIFLS CY  V++  +   ++   +V C    +   Y T         CTI+F+++YF
Sbjct: 269 RPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPAL----CTIVFLLVYF 324

Query: 346 FGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGD 405
           FGMASSIWWVILSLTWFLAAGMKWG+EAI   +QYFHLAAW +P+VK+IT LA+  VDGD
Sbjct: 325 FGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGD 384

Query: 406 LLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLE 465
            ++G+CYVG  ++++LRGFVL PL +YL +GT FLLAGFVSLFRIR+++K  GTKT+KLE
Sbjct: 385 PVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLE 444

Query: 466 KLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGH---FPP 522
           KLM+RIG+F++LYTVPA+IV+ACY YEQ +RE WE      TC        PGH    P 
Sbjct: 445 KLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAA---LTCAC------PGHDTGQPR 495

Query: 523 MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHR 563
             P++ V M+KY M ++VGIT+G WIWSGKT++SWRRF  R
Sbjct: 496 AKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSR 536


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  504 bits (1299), Expect = e-143
 Identities = 285/610 (46%), Positives = 360/610 (59%), Gaps = 106/610 (17%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108
           CQ I++PLC  I YN T +PN   H  Q++AGLEVHQF+PLV++QCSP+L+FFLCSMY P
Sbjct: 35  CQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTP 94

Query: 109 VCTV-LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGE-ICVGQNTS 166
           +C     + +PPCRS+CERA+ GC  LM ++GF WP+R+RC+  P  G  + +C+  N +
Sbjct: 95  ICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRT 154

Query: 167 DGSGGPGGGPTAYPTAPY-LPDLPFTALPPGASDGRGRPAFPFSCPRQ-----------L 214
           D +       TA P+ P  LP  P    PP  S G GRP  P + P              
Sbjct: 155 DLT-------TAAPSPPRRLPPPPPGEQPPSGS-GHGRP--PGARPPHRGGGRGGGGGDA 204

Query: 215 KVPPYLGYRFLGE-RDCG---APCEPGR-------------------------ANGLM-- 243
             PP  G    G+ R  G   APCEPG                          AN  +  
Sbjct: 205 AAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPC 264

Query: 244 ---YFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA 300
              +F ++ER F   W+G+WSVLC  ST  TV T+L+DM RF YPERPIIFLS CY  V+
Sbjct: 265 HNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVS 324

Query: 301 VAHVAGFLLEDRAVCVERFSDD-----GYRTVAQGTKKEG-------------------- 335
           V ++   +     V     +       G    A G    G                    
Sbjct: 325 VGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQ 384

Query: 336 -----------CTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLA 384
                      CT++F+++YFFGMASSIWWVILSLTWFLAAGMKWG+EAI   SQYFHLA
Sbjct: 385 HVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLA 444

Query: 385 AWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGF 444
           AW VP+VK+I +LA+  VDGD ++G+CYVG  S+D LRGFVLAPL +YLFIGT FLLAGF
Sbjct: 445 AWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGF 504

Query: 445 VSLFRIRTIMK-HDG-TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERT 502
           VSLFRIR+++K  DG TKT KLEKLM+R+G+F+VLYTVPA +V+AC FYEQ  R  WE T
Sbjct: 505 VSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEAT 564

Query: 503 WLLQTCKSYAVPCPPGHFPPMS--PDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRF 560
                   +  PC     P  +  PD+ VFM+KY M ++VGIT+G W+WSGKTL+SWR  
Sbjct: 565 --------HNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSL 616

Query: 561 YHRLSHSSKG 570
             R   +SKG
Sbjct: 617 CTRCCWASKG 626


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  493 bits (1269), Expect = e-139
 Identities = 259/552 (46%), Positives = 343/552 (62%), Gaps = 30/552 (5%)

Query: 18  LVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQE 77
           LVL ++G+ +A +          +  P  G CQPI IP+C DI YN T +PNL+GH NQ 
Sbjct: 10  LVLQVMGSCAAISSMD-------MERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQR 62

Query: 78  DAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCRSLCERARQGCEALMN 136
           +A +++H+F PLV+  C   LRFFLCS+YAP+CT  +   IP CR +CE+AR  C  +M 
Sbjct: 63  EAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIME 122

Query: 137 KFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPG 196
           +F F+WP+ L C   P          +  ++GS  P  G   +P   + P  P +A    
Sbjct: 123 QFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPL-FRPQRPHSAQEHP 181

Query: 197 ASDGR-GRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARL 255
             DG  GR      C    K      +       C   C PG     +Y+  E++RFA +
Sbjct: 182 LKDGGPGRGG----CDNPGKF-----HHVEKSASCAPLCTPGVD---VYWSREDKRFAVV 229

Query: 256 WVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVC 315
           W+ +W+VLC  S+ FTVLT+L+D  RF YPERPIIFLS CY + +V ++        ++ 
Sbjct: 230 WLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIA 289

Query: 316 VERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIE 375
            +R S   Y  + +G +  GCT++F+VLY+FGMASS+WWV+L+LTWFLAAG KWGHEAIE
Sbjct: 290 CDRDSGQLY-VIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIE 348

Query: 376 ANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFI 435
           ANS YFHLAAWA+PAVKTI IL M +V GD L+GVCYVG   V+AL GFVL PL  YL I
Sbjct: 349 ANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVI 408

Query: 436 GTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAF 495
           GTSF+L+GFV+LF IR +MK  G  T+KLEKLMVRIG+FSVLYTVPAT V+ACYFYE+  
Sbjct: 409 GTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLN 468

Query: 496 REHWERTWLLQTCK----SYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSG 551
            ++W+       CK    +  + C         P   +FM+K  M ++VGIT+G WIW+ 
Sbjct: 469 MDYWKILAAQHKCKMNNQTKTLDC---LMAASIPAVEIFMVKIFMLLVVGITSGMWIWTS 525

Query: 552 KTLQSWRRFYHR 563
           KTLQSW++   R
Sbjct: 526 KTLQSWQQVCSR 537


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score =  484 bits (1246), Expect = e-137
 Identities = 237/516 (45%), Positives = 316/516 (61%), Gaps = 33/516 (6%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108
           C+PI++ +C D+ YN T +PNLL H +Q+ A L +  F+P+V + CS + R FLC++YAP
Sbjct: 28  CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87

Query: 109 VCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDG 168
           +C    +   PCR LC+RA   C  LM  FG  WPE + C  FP                
Sbjct: 88  ICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP---------------- 131

Query: 169 SGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGER 228
                         P L DL     P   +    +  + F CPR+LK+ P LGY FL  R
Sbjct: 132 --------DCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVR 183

Query: 229 DCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERP 288
           DC  PC        MYF+ EE  FAR ++G+ S++C ++TLFT LT+L+D+ RF YPERP
Sbjct: 184 DCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERP 237

Query: 289 IIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYR--TVAQGTKKEGCTILFMVLYFF 346
           IIF + CY MV++    GFLLEDR  C        Y+  TV QG+  + CT+LFM+LYFF
Sbjct: 238 IIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQ-YKASTVTQGSHNKACTMLFMILYFF 296

Query: 347 GMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDL 406
            MA S+WWVIL++TWFLAA  KWG EAIE  +  FH +AW +P   TI +LAM +++GD 
Sbjct: 297 TMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDN 356

Query: 407 LSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEK 466
           +SGVC+VGL  VDALR FVLAPL +Y+ +G S LLAG +SL R+R  +  +    +KL K
Sbjct: 357 ISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVK 416

Query: 467 LMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPD 526
            M+RIGVFS+LY VP  +V+ CYFYEQA+R  WE TW+ + C+ Y +PCP        PD
Sbjct: 417 FMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPD 476

Query: 527 FTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYH 562
             +F++KYLM +IVGI + FW+ S KT   W  F+H
Sbjct: 477 LILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFH 512


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  459 bits (1181), Expect = e-129
 Identities = 254/570 (44%), Positives = 341/570 (59%), Gaps = 40/570 (7%)

Query: 6   AAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQT 65
           A APL    L   +LA  GA        P  G           CQ + IP+C  I YN T
Sbjct: 2   AVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAP------CQAVEIPMCRGIGYNLT 55

Query: 66  ILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT-VLDQAIPPCRSLC 124
            +PNLLGHT+Q +A  E+ +F PLV+  C   LRFFLCS+YAP+CT  +   IP CR +C
Sbjct: 56  RMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMC 115

Query: 125 ERARQGCEALMNKFGFQWPERLRCENFPVHGAGE-ICVG--QNTSDGSGGPGGGPTAYPT 181
           E+AR  C  +M +F F WP+ L C   P       +C+   +N + G   P  G    P 
Sbjct: 116 EQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPV 175

Query: 182 APYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGE-RDCGAPCEPGRAN 240
           AP  P  P   L PGA  G G      +C    K      ++++ + R C   C PG   
Sbjct: 176 APR-PARPPGDLGPGAG-GSG------TCENPEK------FQYVEKSRSCAPRCGPGVE- 220

Query: 241 GLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA 300
             +++   ++ FA +W+ VWS LC  ST FTVLT+L++  RF YPERPIIFLS CY + +
Sbjct: 221 --VFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYS 278

Query: 301 VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLT 360
           +A +   +   ++V  ++ +   Y  + +G +  GCT++F++LY+FGMASS+WWV+L+LT
Sbjct: 279 LAFLIRAVAGAQSVACDQEAGALY-VIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLT 337

Query: 361 WFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDA 420
           WFLAAG KWGHEAIEA+  YFH+AAW +PA+KTI IL + +V GD L+G+CYV  +   A
Sbjct: 338 WFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAA 397

Query: 421 LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTV 480
           L GFVL PL  YL +G+SFLL GFV+LF IR IMK  GT TEKLEKLMV+IGVFS+LYTV
Sbjct: 398 LTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTV 457

Query: 481 PATIVLACYFYEQAFREHWERTWLLQTCKSYAVP-------CPPGHFPPMSPDFTVFMIK 533
           PAT V+ CY YE+   + W      Q C + A P        P G  P ++    VFM+K
Sbjct: 458 PATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVA----VFMLK 513

Query: 534 YLMTMIVGITTGFWIWSGKTLQSWRRFYHR 563
             M+++VGIT+G W+WS KT Q+W+   +R
Sbjct: 514 IFMSLVVGITSGVWVWSSKTFQTWQSLCYR 543


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score =  458 bits (1178), Expect = e-129
 Identities = 227/518 (43%), Positives = 305/518 (58%), Gaps = 35/518 (6%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108
           C+PI++P C  +AYN T  PNL+GH +Q  A +E+  F PL  ++CSP +  FLC  + P
Sbjct: 24  CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83

Query: 109 VCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDG 168
            C      +PPCR LCE+    C+ L++ FG +WPE L C+        + C        
Sbjct: 84  TCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL------QYCD------- 130

Query: 169 SGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGER 228
                       T P   D     L P     + +    F CPR LK     GY+FLG  
Sbjct: 131 -----------ETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGID 179

Query: 229 DCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERP 288
            C  PC        MYFK +E  FA+ ++G  S+ C  +TLFT LT+L+D+RRF YPERP
Sbjct: 180 QCAPPCPN------MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERP 233

Query: 289 IIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYR---TVAQGTKKEGCTILFMVLYF 345
           II+ S CY +V++ +  GFLL D   C +  +D+      TV  G++ + CT+LFM+LYF
Sbjct: 234 IIYYSVCYSIVSLMYFIGFLLGDSTACNK--ADEKLELGDTVVLGSQNKACTVLFMLLYF 291

Query: 346 FGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGD 405
           F MA ++WWVIL++TWFLAAG KW  EAIE  + +FH  AW  P   T+ +LAM +V+GD
Sbjct: 292 FTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGD 351

Query: 406 LLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLE 465
            +SGVC+VGL  +DA R FVL PL + +F+G S LLAG +SL  +R +++HDG   EKL+
Sbjct: 352 NISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLK 411

Query: 466 KLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSP 525
           K M+RIGVFS LY VP   +L CY YEQ  R  WE TW+   C+ Y +PCP        P
Sbjct: 412 KFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARP 471

Query: 526 DFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHR 563
           +  +FMIKYLMT+IVGI+  FW+ S KT   W  F+ R
Sbjct: 472 ELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  439 bits (1130), Expect = e-123
 Identities = 246/572 (43%), Positives = 330/572 (57%), Gaps = 72/572 (12%)

Query: 4   PGAAAPLS-SLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAY 62
           PGA   +  SLGL   +L LLG              +G    +   C PI I +C ++ Y
Sbjct: 11  PGAPGGVGLSLGLLLQLLLLLGPA------------RGFGDEEERRCDPIRISMCQNLGY 58

Query: 63  NQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCR 121
           N T +PNL+GH  Q DA L++  F PL++  CS +L+FFLCS+Y P+CT  ++  I PC 
Sbjct: 59  NVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCG 118

Query: 122 SLCERARQGCEALMNKFGFQWPERLRCENFPVHGA-GEICVGQNTSDGSGGPGGGPTAYP 180
            +C   ++ CE ++ +FGF WPE L C  FP       +C+         GPG      P
Sbjct: 119 GMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCME--------GPGDEEVPLP 170

Query: 181 TAPYLPDLPFTALPPGA---SDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPG 237
                     T + PG    S G     + +   R L      GY      D G      
Sbjct: 171 HK--------TPIQPGEECHSVGTNSDQYIW-VKRSLNCVLKCGY------DAGL----- 210

Query: 238 RANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYF 297
                  +    + F  +W+ VW+ LC  ST FTVLT+L+D  RFSYPERPIIFLS CY 
Sbjct: 211 -------YSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYN 263

Query: 298 MVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVIL 357
           + ++A++    +    +  +         + +G K  GC I+F+++YFFGMASSIWWVIL
Sbjct: 264 IYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVIL 323

Query: 358 SLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSS 417
           +LTWFLAAG+KWGHEAIE +S YFH+AAWA+PAVKTI IL M  VD D L+G+CYVG  +
Sbjct: 324 TLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQN 383

Query: 418 VDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVL 477
           +DAL GFV+APLF YL IGT F+ AG V+LF+IR+ ++ DGTKT+KLE+LMV+IGVFSVL
Sbjct: 384 LDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVL 443

Query: 478 YTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMT 537
           YTVPAT V+ACYFYE +        W L              +     +  V M+K  M+
Sbjct: 444 YTVPATCVIACYFYEIS-------NWAL------------FRYSADDSNMAVEMLKIFMS 484

Query: 538 MIVGITTGFWIWSGKTLQSWRRFYHRLSHSSK 569
           ++VGIT+G WIWS KTL +W++  +RL +S K
Sbjct: 485 LLVGITSGMWIWSAKTLHTWQKCSNRLVNSGK 516


>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score =  182 bits (461), Expect = 9e-46
 Identities = 142/498 (28%), Positives = 224/498 (44%), Gaps = 74/498 (14%)

Query: 93  QCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRC--EN 150
           +C   ++  LC++Y P C   D+   P R+LC+  R  C  +  + G  WP+ LRC  + 
Sbjct: 117 RCWAVIQPLLCAVYMPKCEN-DRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDR 173

Query: 151 FPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSC 210
           FP     E+   QN    S G    P      P               D  G        
Sbjct: 174 FPEGCTNEV---QNIKFNSSGQCEVPLVRTDNP----------KSWYEDVEG-------- 212

Query: 211 PRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLF 270
                              CG  C+    N L  F E E +    ++  +  +    TLF
Sbjct: 213 -------------------CGIQCQ----NPL--FTEAEHQDMHSYIAAFGAVTGLCTLF 247

Query: 271 TVLTYLVDMRRFS-YPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQ 329
           T+ T++ D R  + YP   + +++ C+F+ ++  +A F+   R   V R   DG   + +
Sbjct: 248 TLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRA--DGTMRLGE 305

Query: 330 GTKKE--GCTILFMVLYFFGMASSIWWVILSLTW---FLAAGMKWGHEAIEANSQYFHLA 384
            T  E   C I+F+++Y+  MA  +W+V+L+  W   F A G  +  + +   + YFHL 
Sbjct: 306 PTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLL 363

Query: 385 AWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGF 444
            W++P V T+ ILA+ QVDGD +SG+C+VG  +     GFVLAP+ + L +G  FL+ G 
Sbjct: 364 TWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGV 423

Query: 445 VSLFRIRTIMKHDGTKTE----KLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWE 500
           ++LF I++   H G  +E    K+ + M+R+G+F  L      I  +C+FY+   +  WE
Sbjct: 424 MTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWE 481

Query: 501 RTW----LLQTCKSYAVPCP---PGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKT 553
           R++    L Q   +  +P     P       P   V  I        GI    W+W+  T
Sbjct: 482 RSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKAT 541

Query: 554 LQSWRRFYHRLSHSSKGE 571
           L  WRR + RL+  S  E
Sbjct: 542 LLIWRRTWCRLTGQSDDE 559


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score =  130 bits (327), Expect = 3e-30
 Identities = 60/129 (46%), Positives = 84/129 (65%), Gaps = 6/129 (4%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108
           C+P+ IPLC  + +N T +PN L H+ Q +A L + QF  L+   CSP+L FFLC+MYAP
Sbjct: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94

Query: 109 VCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQN-- 164
           +CT+    + I PC+S+CERARQGCE ++ K+   WPE L CE  PV+  G +C+     
Sbjct: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-VCISPEAI 153

Query: 165 -TSDGSGGP 172
            T+DG+  P
Sbjct: 154 VTADGADFP 162


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score =  119 bits (299), Expect = 6e-27
 Identities = 54/115 (46%), Positives = 75/115 (65%), Gaps = 3/115 (2%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108
           C+ + IP+C  + +N T +PN L H+ QE+A L + Q+  LV V CS  LRFFLC+MYAP
Sbjct: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83

Query: 109 VCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICV 161
           +CT+  L   I PC+S+C+RAR  CE LM  +   WPE L C+  PV+  G +C+
Sbjct: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRG-VCI 137


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score =  110 bits (276), Expect = 3e-24
 Identities = 65/167 (38%), Positives = 87/167 (52%), Gaps = 17/167 (10%)

Query: 6   AAAPLSSLGLCALVLALLGALS-----------AGAGAQPYHGEKGISVPDHGFCQPISI 54
           AAA    +   AL L LLGAL             G  A+P HG +  S P      P  +
Sbjct: 3   AAAAGGGVRTAALAL-LLGALHWAPARCEEYDYYGWQAEPLHG-RSYSKPPQCLDIPADL 60

Query: 55  PLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLD 114
           PLC  + Y +  LPNLL H +  +   +   + PL+  +C  + + FLCS++APVC  LD
Sbjct: 61  PLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC--LD 118

Query: 115 QAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICV 161
           + I PCRSLCE  R GC  LM  +GF WPE L C  FP+    ++C+
Sbjct: 119 RPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLD--NDLCI 163


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score =  105 bits (262), Expect = 1e-22
 Identities = 57/155 (36%), Positives = 79/155 (50%), Gaps = 13/155 (8%)

Query: 15  LCALVLALLGALSAG--------AGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTI 66
           L AL  ALL   SA         +   PY   +  + P      P  + LC ++ Y + +
Sbjct: 18  LLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMV 77

Query: 67  LPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCER 126
           LPNLL H    +   +   + PL+   C    + FLCS++APVC  LD+ I PCR LCE 
Sbjct: 78  LPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC--LDRPIYPCRWLCEA 135

Query: 127 ARQGCEALMNKFGFQWPERLRCENFPVHGAGEICV 161
            R  CE +M  FGF WPE L+C+ FP    G++C+
Sbjct: 136 VRDSCEPVMQFFGFYWPEMLKCDKFP---EGDVCI 167


>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score =  103 bits (256), Expect = 6e-22
 Identities = 50/122 (40%), Positives = 72/122 (59%), Gaps = 5/122 (4%)

Query: 49  CQPI--SIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMY 106
           C+PI  ++ LC  I Y    LPNLLGH   ++   +   + PLV  QC P+ + FLCS++
Sbjct: 40  CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLF 99

Query: 107 APVC-TVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNT 165
           APVC   LD+ I PC SLC + +  C  +M+ FGF WP+ L C+ FP     ++C+   +
Sbjct: 100 APVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQD--NDLCIPLAS 157

Query: 166 SD 167
           SD
Sbjct: 158 SD 159


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 44/107 (41%), Positives = 63/107 (58%), Gaps = 3/107 (2%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGL--EVHQFYPLVKVQCSPELRFFLCSMY 106
           C+PI++ LC ++ YN T  PN  GH  Q++A +  E   F  LV+  C   L FF C++ 
Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514

Query: 107 APVCTV-LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFP 152
            P C V   + IPPCR+LCE +++ CE+++   G QWPE   C  FP
Sbjct: 515 VPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFP 561



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 4/106 (3%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108
           C  I+   C  + Y+ T+ P L    N E     +  F  L ++ C   +  F C++  P
Sbjct: 139 CMNITHSQCQMLPYHATLTPLLSVVRNMEMEKF-LKFFTYLHRLSCYQHIMLFGCTLAFP 197

Query: 109 VCTVL---DQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENF 151
            C +       + PCRS CE A++GCE+++    + WP+ LRC  F
Sbjct: 198 ECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQF 243


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 3/113 (2%)

Query: 49  CQPISIPLCTDIAYNQTILPNL-LGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYA 107
           C+P+ + +C  ++YN T  PN+ +G   QE+    +  +  L  + C    R  LC +  
Sbjct: 466 CEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLV 525

Query: 108 PVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEIC 160
           P CT L   +PPCRS+C+ A   C++ +   G  WP    C   P     E C
Sbjct: 526 PRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEAADLEAC 576


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 37/112 (33%), Positives = 55/112 (49%), Gaps = 6/112 (5%)

Query: 45  DHGFCQPISIPLCTDIAYNQTILPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSPELR 99
           D   C  + +  C+D AYN T  PNLL H + E  +A  E   +   + L++ QC+P+LR
Sbjct: 39  DSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLR 98

Query: 100 FFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENF 151
              C++ AP C        PCR +CE  R+ C+   +     WP  L C  +
Sbjct: 99  LLGCAVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 149


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 6/108 (5%)

Query: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSPELRFFLC 103
           C  + +  C+D AYN T  PNLL H + E  +A  E   +   + L++ QC+P+LR   C
Sbjct: 32  CVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 91

Query: 104 SMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENF 151
           ++ AP C        PCR +CE  R+ C+   +     WP  L C  +
Sbjct: 92  AVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 138


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 3/88 (3%)

Query: 47  GFCQPI--SIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCS 104
           G C P+  S+P+C  +  ++  LPN L H + E        +  L++  C P L +F C 
Sbjct: 332 GRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCL 391

Query: 105 MYAPVC-TVLDQAIPPCRSLCERARQGC 131
           +  P C +V   A PPC   CE  +  C
Sbjct: 392 LLVPPCGSVPPPAPPPCCQFCEALQDAC 419


>gi|45433552 G protein-coupled receptor 133 [Homo sapiens]
          Length = 874

 Score = 34.7 bits (78), Expect = 0.24
 Identities = 25/107 (23%), Positives = 53/107 (49%), Gaps = 5/107 (4%)

Query: 336 CTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTIT 395
           C ++ ++L++F +++  W ++  L  +      +G E  ++  +Y++   W  P +  I 
Sbjct: 632 CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSE--DSKHRYYYGMGWGFPLLICII 689

Query: 396 ILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLA 442
            L+   +D    S  C++ L+S  A+  FV   LFV + +    L+A
Sbjct: 690 SLSFA-MDSYGTSNNCWLSLAS-GAIWAFVAPALFV-IVVNIGILIA 733


>gi|93204873 G protein-coupled receptor 157 [Homo sapiens]
          Length = 335

 Score = 34.7 bits (78), Expect = 0.24
 Identities = 35/166 (21%), Positives = 66/166 (39%), Gaps = 25/166 (15%)

Query: 283 SYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMV 342
           S   R ++FLS    + A ++  G L        + F+   +  V QG            
Sbjct: 44  SRARRLLLFLSLADLLSAASYFYGVL--------QNFAGPSWDCVLQGALST-------- 87

Query: 343 LYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQV 402
             F   +S  W V ++L  +L+          +     FH+ +W VP V T+  +A+ ++
Sbjct: 88  --FANTSSFFWTVAIALYLYLSIVRAARGPRTDRLLWAFHVVSWGVPLVITVAAVALKKI 145

Query: 403 D---GDLLSGVCYVGLSSVDALRGFVLA----PLFVYLFIGTSFLL 441
                D+  G C++ L + D +   +L      +  Y+ +   +LL
Sbjct: 146 GYDASDVSVGWCWIDLEAKDHVLWMLLTGKLWEMLAYVLLPLLYLL 191


>gi|73476377 LBXCOR1 homolog [Homo sapiens]
          Length = 921

 Score = 33.5 bits (75), Expect = 0.54
 Identities = 23/52 (44%), Positives = 24/52 (46%), Gaps = 9/52 (17%)

Query: 152 PVHGAGEICVGQNTSDGSGGPG-GGPTAYPTAPYLPDLPFTALPPGASDGRG 202
           PV GAGE   G  T  G GG G GG    P A +        LPPGA  G G
Sbjct: 368 PVLGAGEPKGGPGTGSGGGGAGTGGGAGGPGASH--------LPPGAGAGPG 411


>gi|7662494 Kruppel-like factor 15 [Homo sapiens]
          Length = 416

 Score = 33.5 bits (75), Expect = 0.54
 Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)

Query: 162 GQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYL 220
           G  ++ G+ GPGGGPT  P  P    L    +P     G G PA P   P  +KV   L
Sbjct: 197 GGASAGGAQGPGGGPT--PDGPIPVLLQIQPVPVKQESGTG-PASPGQAPENVKVAQLL 252


>gi|7019387 G protein-coupled receptor 132 [Homo sapiens]
          Length = 380

 Score = 32.7 bits (73), Expect = 0.93
 Identities = 18/72 (25%), Positives = 31/72 (43%), Gaps = 2/72 (2%)

Query: 252 FARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYF-MVAVAHVAGFLLE 310
           F  ++V +  + C +   F  + Y ++ R      R  I +S C F +V + H   F  E
Sbjct: 123 FCNIYVSILFLCCISCDRFVAVVYALESRG-RRRRRTAILISACIFILVGIVHYPVFQTE 181

Query: 311 DRAVCVERFSDD 322
           D+  C +    D
Sbjct: 182 DKETCFDMLQMD 193


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score = 31.6 bits (70), Expect = 2.1
 Identities = 25/80 (31%), Positives = 30/80 (37%), Gaps = 7/80 (8%)

Query: 162 GQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLG 221
           G +   G  GPGG P  +P     P  P    PPG     G P      P Q+  PP  G
Sbjct: 213 GGDRFPGPAGPGGPPPPFPAGQTPPRPPLG--PPGPPGPPGPPP-----PGQVLPPPLAG 265

Query: 222 YRFLGERDCGAPCEPGRANG 241
               G+R       PG+  G
Sbjct: 266 PPNRGDRPPPPVLFPGQPFG 285


>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo
            sapiens]
          Length = 1584

 Score = 31.6 bits (70), Expect = 2.1
 Identities = 44/227 (19%), Positives = 89/227 (39%), Gaps = 41/227 (18%)

Query: 263  LCCASTLFTVLTYL---VDMRRFSYPERPIIFLSGC------YFMVAVAHVA--GFLLED 311
            LC   + F +L  L    +M + + P   +  + GC        M+ + +V+   ++  +
Sbjct: 922  LCDRLSTFAILAQLSADANMEKATLPS--VTLIVGCGVSSLTLLMLVIIYVSVWRYIRSE 979

Query: 312  RAV-----CVERFSDDGYRTVAQGT--KKEGCTILFMVLYFFGMASSIWWVILSLTW--F 362
            R+V     C+   S +    + Q     K  CT++   L+FF ++S  W  +L+  W  +
Sbjct: 980  RSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCW--VLTEAWQSY 1037

Query: 363  LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALR 422
            +A     GH       + F    W +PA+     +   +  G      C++ L       
Sbjct: 1038 MAV---TGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGG---- 1090

Query: 423  GFVLAPLFVYLFIGTS---FLLAGFVSLFRIRTIMKHDGTKTEKLEK 466
                    +Y F+G +    L+   + +     ++  DG   +KL++
Sbjct: 1091 -------LLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKE 1130


>gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens]
          Length = 870

 Score = 31.6 bits (70), Expect = 2.1
 Identities = 17/80 (21%), Positives = 39/80 (48%), Gaps = 4/80 (5%)

Query: 335 GCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTI 394
           G  ++F++LY    ++ +W  +L+++ FL        E ++       ++ W +PA+   
Sbjct: 442 GQILVFVLLYSSLYSTYLWTGLLAISLFLLKK----RERVQIPVGIIIISGWGIPALLVG 497

Query: 395 TILAMGQVDGDLLSGVCYVG 414
            +L  G+ +GD +    + G
Sbjct: 498 VLLITGKHNGDSIDSAFFYG 517


>gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo
           sapiens]
          Length = 870

 Score = 31.6 bits (70), Expect = 2.1
 Identities = 17/80 (21%), Positives = 39/80 (48%), Gaps = 4/80 (5%)

Query: 335 GCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTI 394
           G  ++F++LY    ++ +W  +L+++ FL        E ++       ++ W +PA+   
Sbjct: 442 GQILVFVLLYSSLYSTYLWTGLLAISLFLLKK----RERVQIPVGIIIISGWGIPALLVG 497

Query: 395 TILAMGQVDGDLLSGVCYVG 414
            +L  G+ +GD +    + G
Sbjct: 498 VLLITGKHNGDSIDSAFFYG 517


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.142    0.470 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,174,513
Number of Sequences: 37866
Number of extensions: 1291564
Number of successful extensions: 5082
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 4957
Number of HSP's gapped (non-prelim): 107
length of query: 574
length of database: 18,247,518
effective HSP length: 108
effective length of query: 466
effective length of database: 14,157,990
effective search space: 6597623340
effective search space used: 6597623340
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.