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Search of human proteins with 4503823
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
(537 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 1110 0.0
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 1038 0.0
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 950 0.0
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 793 0.0
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 758 0.0
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 758 0.0
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 758 0.0
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 745 0.0
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 745 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 615 e-176
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 586 e-167
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 586 e-167
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 582 e-166
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 582 e-166
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 570 e-162
gi|4503787 fyn-related kinase [Homo sapiens] 489 e-138
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 380 e-105
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 369 e-102
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 369 e-102
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 369 e-102
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 369 e-102
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 368 e-102
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 365 e-101
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 365 e-101
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 355 8e-98
gi|148596974 TXK tyrosine kinase [Homo sapiens] 332 4e-91
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 321 1e-87
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 321 1e-87
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 317 2e-86
gi|187475373 c-src tyrosine kinase [Homo sapiens] 286 4e-77
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 1110 bits (2871), Expect = 0.0
Identities = 537/537 (100%), Positives = 537/537 (100%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240
Query: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
Sbjct: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300
Query: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
Sbjct: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360
Query: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
Sbjct: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420
Query: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
Sbjct: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480
Query: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 1038 bits (2684), Expect = 0.0
Identities = 507/537 (94%), Positives = 514/537 (95%), Gaps = 3/537 (0%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE+A GLC
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240
Query: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300
L V P+ + L+ KD WE+ R SL L K+LG G F EVW+GTWNGNTKVAIKT
Sbjct: 241 NLTVIASSCTPQTSGLA---KDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKT 297
Query: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
Sbjct: 298 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 357
Query: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
Sbjct: 358 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 417
Query: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
Sbjct: 418 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 477
Query: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 478 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 950 bits (2456), Expect = 0.0
Identities = 475/537 (88%), Positives = 478/537 (89%), Gaps = 55/537 (10%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQF
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQF------------------- 221
Query: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300
E+LQ Q + + GTWNGNTKVAIKT
Sbjct: 222 ----------------------------ETLQ--------QLVQHYSGTWNGNTKVAIKT 245
Query: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
Sbjct: 246 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 305
Query: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
Sbjct: 306 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 365
Query: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
Sbjct: 366 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 425
Query: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 426 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 793 bits (2047), Expect = 0.0
Identities = 396/546 (72%), Positives = 444/546 (81%), Gaps = 12/546 (2%)
Query: 1 MGCVQCKDKE--ATKLTEERDGSLNQSSGYRYGTDPT-----PQHYPSFGVTSIPNYNNF 53
MGC++ K+ + A K E +S YG +PT P + + +
Sbjct: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
Query: 54 HAAGGQGLTVFGGVNSSSHTGTLRTRGGT--GVTLFVALYDYEARTEDDLSFHKGEKFQI 111
G G+T FGG +SS G GVT+FVALYDYEART +DLSF KGE+FQI
Sbjct: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
Query: 112 LNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG 171
+N++EGDWWEARS+ TG+ GYIPSNYVAP DSIQAEEWYFGK+GRKDAER LL+ GN RG
Sbjct: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
Query: 172 TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
FL+RESETTKGAYSLSIRDWD+++GD+VKHYKIRKLDNGGYYITTRAQF+TLQ+LV+HY
Sbjct: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
Query: 232 SERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWN 291
+E A GLC +L C P+ L+ KD WEIPRESL+L +LG G FGEVWMGTWN
Sbjct: 241 TEHADGLCHKLTTVCPTVKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWN 297
Query: 292 GNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLL 351
G TKVAIKTLKPGTM PE+FL+EAQIMKKL+HDKLV LYAVVSEEPIYIVTE+M+KGSLL
Sbjct: 298 GTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLL 357
Query: 352 DFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGL 411
DFLK+G+G+ LKLP LVDMAAQ+A GMAYIERMNYIHRDLR+ANILVG L+CKIADFGL
Sbjct: 358 DFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGL 417
Query: 412 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 471
ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TELVTKGRVPYPGM
Sbjct: 418 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMV 477
Query: 472 NREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQY 531
NREVLEQVERGYRMPCPQ CP SLHELM CWKKDP+ERPTFEY+QSFLEDYFTATEPQY
Sbjct: 478 NREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQY 537
Query: 532 QPGENL 537
QPGENL
Sbjct: 538 QPGENL 543
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 758 bits (1958), Expect = 0.0
Identities = 379/540 (70%), Positives = 429/540 (79%), Gaps = 18/540 (3%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERA 235
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 236 AGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK 295
GLC L+ PC P+ L+ KD WEI R S+ L +RLG G FG+VW+GTWNG+TK
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLA---KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK 287
Query: 296 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355
VA+KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK
Sbjct: 288 VAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLK 347
Query: 356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 415
+ EG+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI
Sbjct: 348 NPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407
Query: 416 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 475
+D+EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REV
Sbjct: 408 KDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREV 467
Query: 476 LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 535
LEQVE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 468 LEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 758 bits (1958), Expect = 0.0
Identities = 379/540 (70%), Positives = 429/540 (79%), Gaps = 18/540 (3%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERA 235
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 236 AGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK 295
GLC L+ PC P+ L+ KD WEI R S+ L +RLG G FG+VW+GTWNG+TK
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLA---KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK 287
Query: 296 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355
VA+KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK
Sbjct: 288 VAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLK 347
Query: 356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 415
+ EG+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI
Sbjct: 348 NPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407
Query: 416 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 475
+D+EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REV
Sbjct: 408 KDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREV 467
Query: 476 LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 535
LEQVE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 468 LEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 758 bits (1958), Expect = 0.0
Identities = 379/540 (70%), Positives = 429/540 (79%), Gaps = 18/540 (3%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERA 235
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 236 AGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK 295
GLC L+ PC P+ L+ KD WEI R S+ L +RLG G FG+VW+GTWNG+TK
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLA---KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK 287
Query: 296 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355
VA+KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK
Sbjct: 288 VAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLK 347
Query: 356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 415
+ EG+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI
Sbjct: 348 NPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407
Query: 416 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 475
+D+EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REV
Sbjct: 408 KDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREV 467
Query: 476 LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 535
LEQVE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 468 LEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 745 bits (1923), Expect = 0.0
Identities = 362/478 (75%), Positives = 413/478 (86%), Gaps = 7/478 (1%)
Query: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLC 239
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ A GLC
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 240 CRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIK 299
RL C P+ L+ KD WEIPRESL+L +LG G FGEVWMGTWNG T+VAIK
Sbjct: 242 HRLTTVCPTSKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIK 298
Query: 300 TLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEG 359
TLKPGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G
Sbjct: 299 TLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETG 358
Query: 360 RALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNE 419
+ L+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNE
Sbjct: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418
Query: 420 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 479
YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QV
Sbjct: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478
Query: 480 ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
ERGYRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 745 bits (1923), Expect = 0.0
Identities = 362/478 (75%), Positives = 413/478 (86%), Gaps = 7/478 (1%)
Query: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLC 239
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ A GLC
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 240 CRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIK 299
RL C P+ L+ KD WEIPRESL+L +LG G FGEVWMGTWNG T+VAIK
Sbjct: 242 HRLTTVCPTSKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIK 298
Query: 300 TLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEG 359
TLKPGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G
Sbjct: 299 TLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETG 358
Query: 360 RALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNE 419
+ L+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNE
Sbjct: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418
Query: 420 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 479
YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QV
Sbjct: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478
Query: 480 ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
ERGYRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 615 bits (1585), Expect = e-176
Identities = 301/472 (63%), Positives = 373/472 (79%), Gaps = 7/472 (1%)
Query: 62 TVFGGVNS-SSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
T+ G NS +S+T +R G + + VALYDYEA +DLSF KG++ +L S G+WW
Sbjct: 58 TIKPGPNSHNSNTPGIREAGSEDI-IVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWW 115
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
+ARSL T + GYIPSNYVA VDS++ EEW+F + RKDAERQLL+ GN G+F+IR+SET
Sbjct: 116 KARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSET 175
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240
TKG+YSLS+RD+D +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY + GLC
Sbjct: 176 TKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQ 235
Query: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300
+L VPC P+ KD WEIPRESL+L K+LG GQFGEVWM T+N +TKVA+KT
Sbjct: 236 KLSVPCMSSKPQ----KPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKT 291
Query: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360
+KPG+MS E+FL EA +MK L+HDKLV+L+AVV++EPIYI+TE+M KGSLLDFLK EG
Sbjct: 292 MKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS 351
Query: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420
LP L+D +AQ+A GMA+IE+ NYIHRDLR+ANILV L+CKIADFGLAR+IEDNEY
Sbjct: 352 KQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEY 411
Query: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480
TAR+GAKFPIKWTAPEA +G FTIKSDVWSFGILL E+VT GR+PYPGM+N EV+ +E
Sbjct: 412 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE 471
Query: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 532
RGYRMP P++CP L+ +M+ CWK PEERPTFEY+QS L+D++TATE QYQ
Sbjct: 472 RGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 586 bits (1510), Expect = e-167
Identities = 282/448 (62%), Positives = 355/448 (79%), Gaps = 5/448 (1%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265
R LDNGG+YI+ R F L +LV+HY+ + GLC RL PC P+ +D WE
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ----KPWWEDEWE 239
Query: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
+PRE+L+L++RLG GQFGEVWMG +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +
Sbjct: 240 VPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQR 299
Query: 326 LVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 385
LV+LYAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE N
Sbjct: 300 LVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
Query: 386 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 445
YIHRDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTI
Sbjct: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
Query: 446 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 505
KSDVWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+
Sbjct: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
Query: 506 DPEERPTFEYLQSFLEDYFTATEPQYQP 533
PE+RPTF+YL+S LED+FTATE QYQP
Sbjct: 480 RPEDRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 586 bits (1510), Expect = e-167
Identities = 282/448 (62%), Positives = 355/448 (79%), Gaps = 5/448 (1%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265
R LDNGG+YI+ R F L +LV+HY+ + GLC RL PC P+ +D WE
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ----KPWWEDEWE 239
Query: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
+PRE+L+L++RLG GQFGEVWMG +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +
Sbjct: 240 VPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQR 299
Query: 326 LVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 385
LV+LYAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE N
Sbjct: 300 LVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
Query: 386 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 445
YIHRDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTI
Sbjct: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
Query: 446 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 505
KSDVWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+
Sbjct: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
Query: 506 DPEERPTFEYLQSFLEDYFTATEPQYQP 533
PE+RPTF+YL+S LED+FTATE QYQP
Sbjct: 480 RPEDRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 582 bits (1500), Expect = e-166
Identities = 281/448 (62%), Positives = 352/448 (78%), Gaps = 6/448 (1%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265
R LDNGGYYI+ R F + +++HY ++A GLC RL C P+ KD WE
Sbjct: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ----KPWDKDAWE 220
Query: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
IPRES++L+KRLG GQFGEVWMG +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDK
Sbjct: 221 IPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDK 280
Query: 326 LVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 384
LV+LYAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER
Sbjct: 281 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 340
Query: 385 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 444
NYIHRDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FT
Sbjct: 341 NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT 400
Query: 445 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 504
IKSDVWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK
Sbjct: 401 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWK 460
Query: 505 KDPEERPTFEYLQSFLEDYFTATEPQYQ 532
+ EERPTF+YLQS L+D++TATE QYQ
Sbjct: 461 EKAEERPTFDYLQSVLDDFYTATEGQYQ 488
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 582 bits (1500), Expect = e-166
Identities = 281/448 (62%), Positives = 352/448 (78%), Gaps = 6/448 (1%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 67 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265
R LDNGGYYI+ R F + +++HY ++A GLC RL C P+ KD WE
Sbjct: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ----KPWDKDAWE 241
Query: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
IPRES++L+KRLG GQFGEVWMG +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDK
Sbjct: 242 IPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDK 301
Query: 326 LVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 384
LV+LYAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER
Sbjct: 302 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 361
Query: 385 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 444
NYIHRDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FT
Sbjct: 362 NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT 421
Query: 445 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 504
IKSDVWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK
Sbjct: 422 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWK 481
Query: 505 KDPEERPTFEYLQSFLEDYFTATEPQYQ 532
+ EERPTF+YLQS L+D++TATE QYQ
Sbjct: 482 EKAEERPTFDYLQSVLDDFYTATEGQYQ 509
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 570 bits (1469), Expect = e-162
Identities = 283/446 (63%), Positives = 349/446 (78%), Gaps = 8/446 (1%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
VALYDY A + DL KGEK Q+L + GDWW ARSL TG GY+PSN+VA V+S++ E
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
Query: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
W+F GRK+AERQLL+ N G+FLIRESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
Query: 208 LDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIP 267
LD GGYYI+ R F +LQ LVQHYS++ GLC RL +PC + P+ + +D WEIP
Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQ----NPWAQDEWEIP 237
Query: 268 RESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLV 327
R+SL+L+++LG+GQFGEVWMG + N KVAIKTLK GTMSPE+FL EA +MK L+H++LV
Sbjct: 238 RQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLV 297
Query: 328 QLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387
+LYAVV++EPIYIVTEYM +G LLDFLK EG L LP L+DM+AQ+A GMAYIERMN I
Sbjct: 298 RLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSI 357
Query: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447
HRDLR+ANILV L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+
Sbjct: 358 HRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKA 416
Query: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKD 506
DVWSFG+LL E+VT GRVPYPGM+N EV+ +ERGYRMP P CP L+ ++ CW+
Sbjct: 417 DVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSR 476
Query: 507 PEERPTFEYLQSFLEDYFTATEPQYQ 532
PEERPTFE+LQS LED++TATE QY+
Sbjct: 477 PEERPTFEFLQSVLEDFYTATERQYE 502
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 489 bits (1259), Expect = e-138
Identities = 249/462 (53%), Positives = 320/462 (69%), Gaps = 18/462 (3%)
Query: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETG-------YIPSNYVA 139
FVAL+DY+ART +DLSF G+K Q+L++ WW AR L G YIPSNYVA
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 140 PVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH 199
S+QAE W+FG +GR DAE+QLL N G+FLIRESE+ KG +SLS+ D G
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
Query: 200 VKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSV 258
VKHY+I++LD GG+++T R F TL + V HY++ + GLC +L PC K +P DLS
Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
Query: 259 KTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 318
KT D WEI R S+QL+KRLG+GQFGEVW G WN T VA+KTLKPG+M P FL EAQIM
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
Query: 319 KKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 377
K L+H KL+QLYAV + E+PIYI+TE M GSL ++L++ G + L VDMAAQVA+G
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
Query: 378 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTA 434
MAY+E NYIHRDL + N+LVG I K+ADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
Query: 435 PEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS 494
PEA +F+IKSDVWSFGILL E++T G++PY GM +V++ + + YR+P P +CP
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
Query: 495 LHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 536
+ +M+ CW +P+ERPTFE L+ LEDYF T+ Y N
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 380 bits (975), Expect = e-105
Identities = 194/448 (43%), Positives = 277/448 (61%), Gaps = 15/448 (3%)
Query: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET---GYIPSNYVAPVDS 143
+V L+D+++RT+++LSF G+ F + E WW G GY+P NY+A ++
Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
+++E W+FG + R +A R+L + GN G FLIR SE Y LS+RD V+HY
Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
Query: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDV 263
KI + G ++ F +L +LV ++ ++ RL PC K P + D
Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPE----PLPHWDD 183
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLE-EAQIMKKLK 322
WE PRE L ++LG+G FGEV+ G W +VAIK + + + L+ E Q MKKL+
Sbjct: 184 WERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR 243
Query: 323 HDKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H ++ LYAVVS +P+YI+TE M KGSLL+ L+D + + L + L+D+A QVA GM Y+
Sbjct: 244 HKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 303
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E NYIHRDL + NILVG +CK+ DFGLARLI+++ Y + P KWTAPEA G
Sbjct: 304 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRG 362
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
++ KSDVWSFGILL E+ ++G+VPYPGM+N E +V+ GYRMPCP +CP S+H+LM+
Sbjct: 363 HYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLT 422
Query: 502 CWKKDPEERPTFEYLQSFLEDYFTATEP 529
CW +DPE+RP F+ L+ L + + P
Sbjct: 423 CWCRDPEQRPCFKALRERLSSFTSYENP 450
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 369 bits (946), Expect = e-102
Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 265
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 266 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 325
Query: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 445
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 446 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 505
Query: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
CWK P +RP+F E F + + E L
Sbjct: 506 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 369 bits (946), Expect = e-102
Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 280
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 340
Query: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 460
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 461 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520
Query: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
CWK P +RP+F E F + + E L
Sbjct: 521 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 369 bits (946), Expect = e-102
Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 265
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 266 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 325
Query: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 445
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 446 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 505
Query: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
CWK P +RP+F E F + + E L
Sbjct: 506 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 369 bits (946), Expect = e-102
Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 185
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 244
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 245 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 304
Query: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 305 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 364
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 365 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 424
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 425 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 484
Query: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
CWK P +RP+F E F + + E L
Sbjct: 485 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 368 bits (945), Expect = e-102
Identities = 199/443 (44%), Positives = 277/443 (62%), Gaps = 14/443 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 200
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 259
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 260 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 319
Query: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 320 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 379
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 380 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 439
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 440 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 499
Query: 502 CWKKDPEERPTFEYLQSFLEDYF 524
CWK P +RP+F E F
Sbjct: 500 CWKWSPADRPSFAETHQAFETMF 522
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 365 bits (937), Expect = e-101
Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 14/443 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L + G+W EA+ T G++PSNY+ PV+S+
Sbjct: 65 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 122
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
I +G Y+++ ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PNYDK 234
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
WE+ R + + +LG GQ+GEV+ G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 294
Query: 323 HDKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H LVQL V + EP YI+TE+M G+LLD+L++ + + L+ MA Q+++ M Y+
Sbjct: 295 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 354
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 355 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 414
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
+F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ YRM P+ CP ++ELM
Sbjct: 415 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 474
Query: 502 CWKKDPEERPTFEYLQSFLEDYF 524
CW+ +P +RP+F + E F
Sbjct: 475 CWQWNPSDRPSFAEIHQAFETMF 497
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 365 bits (937), Expect = e-101
Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 14/443 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L + G+W EA+ T G++PSNY+ PV+S+
Sbjct: 84 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 141
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 142 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 194
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
I +G Y+++ ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 195 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PNYDK 253
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
WE+ R + + +LG GQ+GEV+ G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 254 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 313
Query: 323 HDKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
H LVQL V + EP YI+TE+M G+LLD+L++ + + L+ MA Q+++ M Y+
Sbjct: 314 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 373
Query: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 374 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 433
Query: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
+F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ YRM P+ CP ++ELM
Sbjct: 434 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 493
Query: 502 CWKKDPEERPTFEYLQSFLEDYF 524
CW+ +P +RP+F + E F
Sbjct: 494 CWQWNPSDRPSFAEIHQAFETMF 516
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 355 bits (910), Expect = 8e-98
Identities = 190/438 (43%), Positives = 263/438 (60%), Gaps = 15/438 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--DS 143
LF+ALYD+ AR +LS +G++ L G + R G +P +VA ++
Sbjct: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
+ + WYF + R A++ LLS N G FLIR SE++ G YSLS+R V HY
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR-----AQAKVCHY 169
Query: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDV 263
++ +G Y+ F L++L+ +Y + L+ PC MP+ +DV
Sbjct: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPC---MPQ----KAPRQDV 222
Query: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 323
WE P L ++LG G FGEVW G W G+ VAIK +K M +E Q +K L+H
Sbjct: 223 WERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
Query: 324 DKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 382
++L++L+AV S EP+YIVTE M KG+L FL EGRAL+LP L+ A QVA GM+Y+E
Sbjct: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
Query: 383 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 442
+HRDL + N+LV +GL CK+ADFGLARL++D+ Y+ +K P+KWTAPEAA Y
Sbjct: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
Query: 443 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 502
F+ KSDVWSFG+LL E+ T G+ PY GM N E L+Q+ RGYR+P P CP ++ LM+ C
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
Query: 503 WKKDPEERPTFEYLQSFL 520
W+ PEERP+F L+ L
Sbjct: 463 WRSSPEERPSFATLREKL 480
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 332 bits (852), Expect = 4e-91
Identities = 173/432 (40%), Positives = 265/432 (61%), Gaps = 8/432 (1%)
Query: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP--VDSIQA 146
ALYD+ R +L+ + E++ IL WW+AR G G IPSNYV + +++
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
Query: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKHYKI 205
EWY + R AE LL + G F++R+S G+Y++S+ + +KHY+I
Sbjct: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265
+K D+G +Y+ R F+++ +L+ ++ AAGL RL P L + + + WE
Sbjct: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
Query: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
I L IK +G+GQFG V +G W + +VAIK + G+MS E F+EEA++M KL H K
Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
Query: 326 LVQLYAV-VSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 384
LVQLY V + +P+YIVTE+M G LL++L++ +G+ L+ L+ + + GM Y+ER
Sbjct: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
Query: 385 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 444
YIHRDL + N LV + I KI+DFG+ R + D+EY + GAKFPIKW+ PE L+ +++
Sbjct: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
Query: 445 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 504
KSDVWSFG+L+ E+ T+G++P+ +N +V+E + G+R+ P P+S++E+M CW
Sbjct: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
Query: 505 KDPEERPTFEYL 516
+ PE RPTF L
Sbjct: 505 EKPEGRPTFAEL 516
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 321 bits (822), Expect = 1e-87
Identities = 172/442 (38%), Positives = 258/442 (58%), Gaps = 15/442 (3%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV-DSIQA 146
VALYDY +DL KG+++ IL S WW AR G+ GYIPSNYV DSI+
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
Query: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI--RDWDDMKGDHVKHYK 204
EWY + R AE QLL G F++R+S G Y++S+ + D +G ++HY
Sbjct: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYV 335
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPC---HKGMPRLTDLSVKTK 261
+ YY+ + F T+ +L+ ++ +AGL RL P +K P L +
Sbjct: 336 VCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS- 394
Query: 262 DVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKL 321
WEI + L +K LG GQFG V G W G VAIK +K G+MS + F+EEA++M L
Sbjct: 395 --WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 452
Query: 322 KHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 380
H+KLVQLY V +++ PI+I+TEYM G LL++L++ R + L++M V M Y
Sbjct: 453 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEY 511
Query: 381 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 440
+E ++HRDL + N LV + + K++DFGL+R + D+EYT+ G+KFP++W+ PE +Y
Sbjct: 512 LESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMY 571
Query: 441 GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 500
+F+ KSD+W+FG+L+ E+ + G++PY N E E + +G R+ P ++ +M
Sbjct: 572 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMY 631
Query: 501 HCWKKDPEERPTFEYLQSFLED 522
CW + +ERPTF+ L S + D
Sbjct: 632 SCWHEKADERPTFKILLSNILD 653
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 321 bits (822), Expect = 1e-87
Identities = 177/452 (39%), Positives = 265/452 (58%), Gaps = 16/452 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDS-- 143
+ VA+YD++A DL +G+++ IL ++ WW AR G GYIPSNYV S
Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKH 202
+ EWY + R AE QLL + G F++R+S + G Y++S+ +G +H
Sbjct: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
Query: 203 YKIRKLDNGG--YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCH---KGMPRLTDLS 257
Y I++ YY+ + F ++ ++++++ AAGL RL P K P S
Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Query: 258 VKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQI 317
+ WEI L ++ LG+G FG V +G W KVAIK ++ G M E F+EEA++
Sbjct: 360 YEK---WEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKV 416
Query: 318 MKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 376
M KL H KLVQLY V +++ PIYIVTE+M +G LL+FL+ +G + L+ M V
Sbjct: 417 MMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCE 475
Query: 377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE 436
GM Y+ER ++IHRDL + N LV + K++DFG+AR + D++YT+ GAKFP+KW PE
Sbjct: 476 GMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPE 535
Query: 437 AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLH 496
Y RF+ KSDVWSFG+L+ E+ T+GR+P+ N EV+ V RG+R+ P+ ++
Sbjct: 536 VFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVY 595
Query: 497 ELMIHCWKKDPEERPTFEYLQSFLEDYFTATE 528
E+M+ CW++ PE RP+FE L +++ E
Sbjct: 596 EVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 317 bits (811), Expect = 2e-86
Identities = 163/439 (37%), Positives = 257/439 (58%), Gaps = 11/439 (2%)
Query: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--D 142
T+ +ALYDY+ +L+ + E++ +L+SSE WW + G GY+PS+Y+ +
Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
Query: 143 SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH--V 200
+++ EWY + R AE+ LL G G F++R+S T G Y++S+ + ++ +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
Query: 201 KHYKIRKLDNGG--YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSV 258
KHY I++ ++ YY+ + F+++ L+ ++ GL RL P G + +
Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
Query: 259 KTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 318
W I L ++ +G+GQFG V +G W KVAIKT++ G MS E F+EEA++M
Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
Query: 319 KKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 377
KL H KLVQLY V E+ PI +V E+M G L D+L+ G L+ M V G
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEG 469
Query: 378 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 437
MAY+E IHRDL + N LVG + K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
Query: 438 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE 497
+ R++ KSDVWSFG+L+ E+ ++G++PY +N EV+E + G+R+ P+ +++
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
Query: 498 LMIHCWKKDPEERPTFEYL 516
+M HCWK+ PE+RP F L
Sbjct: 590 IMNHCWKERPEDRPAFSRL 608
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 286 bits (731), Expect = 4e-77
Identities = 171/449 (38%), Positives = 258/449 (57%), Gaps = 37/449 (8%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
+A Y++ E DL F KG+ I+ + + +W++A++ G G IP+NYV + ++A
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
Query: 147 EE------WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
W+ GK+ R+ AER L + G FL+RES G Y+L + D K +H
Sbjct: 74 GTKLSLMPWFHGKITREQAERLL--YPPETGLFLVRESTNYPGDYTLCVSC--DGKVEHY 129
Query: 201 K-HYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVK 259
+ Y KL I FE L QLV+HY+ A GLC RL+ P++ + +V
Sbjct: 130 RIMYHASKLS-----IDEEVYFENLMQLVEHYTSDADGLCTRLI------KPKVMEGTVA 178
Query: 260 TKDV-----WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEE 314
+D W + + L+L++ +G G+FG+V +G + GN KVA+K +K + ++FL E
Sbjct: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAE 236
Query: 315 AQIMKKLKHDKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAA 372
A +M +L+H LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ +
Sbjct: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296
Query: 373 QVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKW 432
V M Y+E N++HRDL + N+LV + K++DFGL + + T K P+KW
Sbjct: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKW 352
Query: 433 TAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP 492
TAPEA +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP
Sbjct: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412
Query: 493 ISLHELMIHCWKKDPEERPTFEYLQSFLE 521
+++E+M +CW D RP+F L+ LE
Sbjct: 413 PAVYEVMKNCWHLDAAMRPSFLQLREQLE 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,316,317
Number of Sequences: 37866
Number of extensions: 972507
Number of successful extensions: 4851
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 794
Number of HSP's successfully gapped in prelim test: 302
Number of HSP's that attempted gapping in prelim test: 2260
Number of HSP's gapped (non-prelim): 1377
length of query: 537
length of database: 18,247,518
effective HSP length: 107
effective length of query: 430
effective length of database: 14,195,856
effective search space: 6104218080
effective search space used: 6104218080
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.