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Search of human proteins with 4503787
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503787 fyn-related kinase [Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503787 fyn-related kinase [Homo sapiens] 1036 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 489 e-138
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 473 e-133
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 469 e-132
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 469 e-132
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 468 e-132
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 468 e-132
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 464 e-131
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 462 e-130
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 462 e-130
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 462 e-130
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 460 e-129
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 449 e-126
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 449 e-126
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 446 e-125
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 380 e-105
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 380 e-105
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 378 e-105
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 374 e-103
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 370 e-102
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 370 e-102
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 370 e-102
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 370 e-102
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 370 e-102
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 370 e-102
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 324 1e-88
gi|148596974 TXK tyrosine kinase [Homo sapiens] 315 6e-86
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 304 1e-82
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 296 2e-80
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 278 1e-74
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 1036 bits (2680), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 60
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED
Sbjct: 1 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 60
Query: 61 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 120
LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA
Sbjct: 61 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 120
Query: 121 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 180
IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR
Sbjct: 121 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 180
Query: 181 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 240
RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL
Sbjct: 181 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 240
Query: 241 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 300
GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED
Sbjct: 241 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 300
Query: 301 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 360
PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV
Sbjct: 301 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 360
Query: 361 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 420
LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG
Sbjct: 361 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 420
Query: 421 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 480
ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF
Sbjct: 421 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 480
Query: 481 ETLRWKLEDYFETDSSYSDANNFIR 505
ETLRWKLEDYFETDSSYSDANNFIR
Sbjct: 481 ETLRWKLEDYFETDSSYSDANNFIR 505
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 489 bits (1259), Expect = e-138
Identities = 249/462 (53%), Positives = 320/462 (69%), Gaps = 18/462 (3%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+DY+ART +DLSF G+K Q+L++ WW AR L G YIPSNYVA
Sbjct: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETG-------YIPSNYVA 139
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG +GR DAE+QLL N G+FLIRESE+ KG +SLS+ D G
Sbjct: 140 PVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH 199
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GG+++T R F TL + V HY++ + GLC +L PC K +P DLS
Sbjct: 200 VKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSV 258
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
KT D WEI R S+QL+KRLG+GQFGEVW G WN T VA+KTLKPG+M P FL EAQIM
Sbjct: 259 KTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 318
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K L+H KL+QLYAV + E+PIYI+TE M GSL ++L++ G + L VDMAAQVA+G
Sbjct: 319 KKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 377
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NYIHRDL + N+LVG I K+ADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 378 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTA 434
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGILL E++T G++PY GM +V++ + + YR+P P +CP
Sbjct: 435 PEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS 494
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
+ +M+ CW +P+ERPTFE L+ LEDYF T+ Y N
Sbjct: 495 LHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 536
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 473 bits (1217), Expect = e-133
Identities = 245/456 (53%), Positives = 316/456 (69%), Gaps = 23/456 (5%)
Query: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
VAL+DY+A EDLSF+ GD++ VL+ E WW AR L R++G YIPSNYVA
Sbjct: 84 VALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEG-------YIPSNYVAR 135
Query: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAVV 162
SL+ E WFF I R DAE+QLL N GSF+IR+SE+ KG +SLSV D G V
Sbjct: 136 VDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTV 195
Query: 163 KHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYK 222
KHY+I+ LD GGF+++ R FSTL E V HY K +DGLC KL PC+ + P++
Sbjct: 196 KHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEK--- 252
Query: 223 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMK 282
D WEI R S++L K+LG+GQFGEVW +N T VAVKT+KPGSM FL EA +MK
Sbjct: 253 --DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMK 310
Query: 283 NLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGM 342
L+H KL++L+AV T E PIYIITE M GSL ++L++D GSK L + +D +AQ+A GM
Sbjct: 311 TLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGM 369
Query: 343 AYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAP 402
A++E RNYIHRDL A N+LV + K+ADFGLARV + DNE Y +R K P+KWTAP
Sbjct: 370 AFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE-DNE--YTAREGAKFPIKWTAP 426
Query: 403 EAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQF 462
EAI F+IKSDVWSFGILL EI+TYG++PY GM+ +VI+ L + YR+P+P NCP++
Sbjct: 427 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL 486
Query: 463 YNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497
YNIM+ CW P+ERPTFE ++ L+D++ T+S Y
Sbjct: 487 YNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQY 522
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 469 bits (1206), Expect = e-132
Identities = 240/463 (51%), Positives = 319/463 (68%), Gaps = 22/463 (4%)
Query: 41 QRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYI 100
+ G VAL+ Y +DLSF+ G+K++VL+ H WW A+ L +++G +I
Sbjct: 41 EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEG-------FI 92
Query: 101 PSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-- 158
PSNYVA+ +L+ E WFF I R DAE+QLL N G+FLIRESE+ KG FSLSV D
Sbjct: 93 PSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFD 152
Query: 159 ---GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPA 215
G V+KHY+I+ LD GG++++ R F +++ + HY K +DGLC +L K C+ +
Sbjct: 153 PVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK 212
Query: 216 PFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFL 275
P+D D WEI R SI+L+KRLG+GQFGEVW G +NN+T VAVKTLKPG+M FL
Sbjct: 213 PWDK-----DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFL 267
Query: 276 REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMA 335
EA +MK L+H KL++LYAV T E+PIYIITE M GSL ++L++D G K+ L + +D +
Sbjct: 268 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFS 327
Query: 336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL 395
AQ+A GMAY+E +NYIHRDL A NVLV E + K+ADFGLARV + DNE Y +R K
Sbjct: 328 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE-DNE--YTAREGAKF 384
Query: 396 PVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP 455
P+KWTAPEAI F+IKSDVWSFGILLYEI+TYGK+PY G T A V+ L+Q YR+P+
Sbjct: 385 PIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV 444
Query: 456 SNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497
NCP + Y+IM CW + +ERPTF+ L+ L+D++ T+ Y
Sbjct: 445 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQY 487
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 469 bits (1206), Expect = e-132
Identities = 240/463 (51%), Positives = 319/463 (68%), Gaps = 22/463 (4%)
Query: 41 QRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYI 100
+ G VAL+ Y +DLSF+ G+K++VL+ H WW A+ L +++G +I
Sbjct: 62 EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEG-------FI 113
Query: 101 PSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-- 158
PSNYVA+ +L+ E WFF I R DAE+QLL N G+FLIRESE+ KG FSLSV D
Sbjct: 114 PSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFD 173
Query: 159 ---GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPA 215
G V+KHY+I+ LD GG++++ R F +++ + HY K +DGLC +L K C+ +
Sbjct: 174 PVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK 233
Query: 216 PFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFL 275
P+D D WEI R SI+L+KRLG+GQFGEVW G +NN+T VAVKTLKPG+M FL
Sbjct: 234 PWDK-----DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFL 288
Query: 276 REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMA 335
EA +MK L+H KL++LYAV T E+PIYIITE M GSL ++L++D G K+ L + +D +
Sbjct: 289 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFS 348
Query: 336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL 395
AQ+A GMAY+E +NYIHRDL A NVLV E + K+ADFGLARV + DNE Y +R K
Sbjct: 349 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE-DNE--YTAREGAKF 405
Query: 396 PVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP 455
P+KWTAPEAI F+IKSDVWSFGILLYEI+TYGK+PY G T A V+ L+Q YR+P+
Sbjct: 406 PIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV 465
Query: 456 SNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497
NCP + Y+IM CW + +ERPTF+ L+ L+D++ T+ Y
Sbjct: 466 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQY 508
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 468 bits (1205), Expect = e-132
Identities = 240/462 (51%), Positives = 317/462 (68%), Gaps = 21/462 (4%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+DY++RT DLSF+ G++LQ+++ WW A L S GYIPSNYVA
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSL-------STGQTGYIPSNYVA 141
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG I R ++E+ LL +EN G+FL+RESE+ KG + LSV D G
Sbjct: 142 PSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN 201
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GGF++T R F++L + V++Y+K +DGLC +L C P L+
Sbjct: 202 VKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC-PTSKPQTQGLAK 260
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
D WEI R S++L +LG G FGEVW G WN TT VA+KTLKPG+M P FL+EAQ+M
Sbjct: 261 ---DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K LRH KL+QLYAV + E+PIYI+TE M GSL ++L+ +TG + L Q VDMAAQ+ASG
Sbjct: 318 KKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NY+HRDL A N+LVGE+ + KVADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE--YTARQGAKFPIKWTA 433
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGILL E+ T G++PY GM +V+ + + YR+P P CP+
Sbjct: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
+++M +CW EP+ERPTFE L+ LEDYF T+ Y N
Sbjct: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 535
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 468 bits (1205), Expect = e-132
Identities = 240/462 (51%), Positives = 317/462 (68%), Gaps = 21/462 (4%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+DY++RT DLSF+ G++LQ+++ WW A L S GYIPSNYVA
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSL-------STGQTGYIPSNYVA 141
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG I R ++E+ LL +EN G+FL+RESE+ KG + LSV D G
Sbjct: 142 PSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN 201
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GGF++T R F++L + V++Y+K +DGLC +L C P L+
Sbjct: 202 VKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC-PTSKPQTQGLAK 260
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
D WEI R S++L +LG G FGEVW G WN TT VA+KTLKPG+M P FL+EAQ+M
Sbjct: 261 ---DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K LRH KL+QLYAV + E+PIYI+TE M GSL ++L+ +TG + L Q VDMAAQ+ASG
Sbjct: 318 KKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NY+HRDL A N+LVGE+ + KVADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE--YTARQGAKFPIKWTA 433
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGILL E+ T G++PY GM +V+ + + YR+P P CP+
Sbjct: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
+++M +CW EP+ERPTFE L+ LEDYF T+ Y N
Sbjct: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 535
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 464 bits (1194), Expect = e-131
Identities = 238/462 (51%), Positives = 313/462 (67%), Gaps = 21/462 (4%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+DY+ART EDLSF+ G++ Q+++ WW AR + ++G YIPSNYVA
Sbjct: 96 FVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNG-------YIPSNYVA 148
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG +GR DAE+ LL N+ G FL+RESE+ KG +SLS+ D G
Sbjct: 149 PADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDN 208
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GG+++T R F TL + V HYT+ +DGLC KL C ++ P L+
Sbjct: 209 VKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVK-PQTQGLAK 267
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
D WEI R S++L +LG G FGEVW G WN TT VA+KTLKPG+M P FL+EAQIM
Sbjct: 268 ---DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K LRH KL+ LYAV + E+PIYI+TE M GSL ++L+ G + L Q VDMAAQ+A G
Sbjct: 325 KKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NYIHRDL A N+LVGE+ + K+ADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE-DNE--YTARQGAKFPIKWTA 440
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGIL E++T G++PY GM +V++ + + YR+P P CP+
Sbjct: 441 PEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 500
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
+ +M CW +P ERPTFE ++ LEDYF T+ Y N
Sbjct: 501 LHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGEN 542
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 462 bits (1189), Expect = e-130
Identities = 240/450 (53%), Positives = 303/450 (67%), Gaps = 20/450 (4%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
F+AL+DY+ART +DL+F G+K +L+ WW AR L + G IPSNYVA
Sbjct: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGC-------IPSNYVA 134
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG IGR DAE+QLL N G+FLIRESE+ KG +SLS+ D G
Sbjct: 135 PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH 194
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GG+++T R F+++ E V HY + +DGLC L PC I P L+
Sbjct: 195 VKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK 253
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
D WEI R+SI L +RLG+G FG+VW G WN +T VAVKTLKPG+M P FL EAQ+M
Sbjct: 254 ---DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K LRH KL+QLYAV + E+PIYI+TE M HGSL ++L+N G + L Q VDMAAQVA G
Sbjct: 311 KLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NYIHRDL A N+LVGE K+ADFGLAR+ K +D Y K P+KWTA
Sbjct: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIK---DDEYNPCQGSKFPIKWTA 426
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGILL E+IT G++PY GM +V++ + Q Y +P P CP
Sbjct: 427 PEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPAS 486
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491
Y M + W +P+ERPTFE L+ LEDYF
Sbjct: 487 LYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 462 bits (1189), Expect = e-130
Identities = 240/450 (53%), Positives = 303/450 (67%), Gaps = 20/450 (4%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
F+AL+DY+ART +DL+F G+K +L+ WW AR L + G IPSNYVA
Sbjct: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGC-------IPSNYVA 134
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG IGR DAE+QLL N G+FLIRESE+ KG +SLS+ D G
Sbjct: 135 PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH 194
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GG+++T R F+++ E V HY + +DGLC L PC I P L+
Sbjct: 195 VKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK 253
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
D WEI R+SI L +RLG+G FG+VW G WN +T VAVKTLKPG+M P FL EAQ+M
Sbjct: 254 ---DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K LRH KL+QLYAV + E+PIYI+TE M HGSL ++L+N G + L Q VDMAAQVA G
Sbjct: 311 KLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NYIHRDL A N+LVGE K+ADFGLAR+ K +D Y K P+KWTA
Sbjct: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIK---DDEYNPCQGSKFPIKWTA 426
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGILL E+IT G++PY GM +V++ + Q Y +P P CP
Sbjct: 427 PEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPAS 486
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491
Y M + W +P+ERPTFE L+ LEDYF
Sbjct: 487 LYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 462 bits (1189), Expect = e-130
Identities = 240/450 (53%), Positives = 303/450 (67%), Gaps = 20/450 (4%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
F+AL+DY+ART +DL+F G+K +L+ WW AR L + G IPSNYVA
Sbjct: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGC-------IPSNYVA 134
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG IGR DAE+QLL N G+FLIRESE+ KG +SLS+ D G
Sbjct: 135 PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH 194
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GG+++T R F+++ E V HY + +DGLC L PC I P L+
Sbjct: 195 VKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK 253
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
D WEI R+SI L +RLG+G FG+VW G WN +T VAVKTLKPG+M P FL EAQ+M
Sbjct: 254 ---DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K LRH KL+QLYAV + E+PIYI+TE M HGSL ++L+N G + L Q VDMAAQVA G
Sbjct: 311 KLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NYIHRDL A N+LVGE K+ADFGLAR+ K +D Y K P+KWTA
Sbjct: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIK---DDEYNPCQGSKFPIKWTA 426
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGILL E+IT G++PY GM +V++ + Q Y +P P CP
Sbjct: 427 PEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPAS 486
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491
Y M + W +P+ERPTFE L+ LEDYF
Sbjct: 487 LYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 460 bits (1183), Expect = e-129
Identities = 238/462 (51%), Positives = 307/462 (66%), Gaps = 21/462 (4%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+DY+ART +DLSF G+K Q+L++ WW AR L G YIPSNYVA
Sbjct: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETG-------YIPSNYVA 139
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
S+QAE W+FG +GR DAE+QLL N G+FLIRESE+ KG +SLS+ D G
Sbjct: 140 PVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH 199
Query: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
VKHY+I++LD GG+++T R F TL + V HY++ +DGLC L I S
Sbjct: 200 VKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNL----TVIASSCTPQTSG 255
Query: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
D WE+ R S+ L K+LG G F EVW G WN T VA+KTLKPG+M P FL EAQIM
Sbjct: 256 LAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 315
Query: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
K L+H KL+QLYAV + E+PIYI+TE M GSL ++L++ G + L VDMAAQVA+G
Sbjct: 316 KKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 374
Query: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
MAY+E NYIHRDL + N+LVG I K+ADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 375 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTA 431
Query: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
PEA +F+IKSDVWSFGILL E++T G++PY GM +V++ + + YR+P P +CP
Sbjct: 432 PEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS 491
Query: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
+ +M+ CW +P+ERPTFE L+ LEDYF T+ Y N
Sbjct: 492 LHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 533
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 449 bits (1155), Expect = e-126
Identities = 233/466 (50%), Positives = 314/466 (67%), Gaps = 23/466 (4%)
Query: 38 PQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQ 97
P S + +AL Y+ DL F G++L++L+ E WW A+ L ++G
Sbjct: 57 PASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGE-WWKAQSLTTGQEG------ 109
Query: 98 GYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL 157
+IP N+VA+ SL+ EPWFF + R DAE+QLL N GSFLIRESES G FSLSV
Sbjct: 110 -FIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVR 168
Query: 158 D-----GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQ 212
D G VVKHY+I+ LD GGF+++ R F L+E V HYT SDGLC +L +PC +
Sbjct: 169 DFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQK 228
Query: 213 VPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN 272
P+ D+WE+ R +++L++RLG+GQFGEVW G +N T VAVK+LK GSM P+
Sbjct: 229 PQKPW-----WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD 283
Query: 273 DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV 332
FL EA +MK L+H +L++LYAV T ++PIYIITE M +GSL ++L+ +G K+ + + +
Sbjct: 284 AFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLL 342
Query: 333 DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE 392
DMAAQ+A GMA++E RNYIHRDL A N+LV + K+ADFGLAR+ + DNE Y +R
Sbjct: 343 DMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNE--YTAREG 399
Query: 393 IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRL 452
K P+KWTAPEAI F+IKSDVWSFGILL EI+T+G++PY GMT +VIQ L + YR+
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
Query: 453 PQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497
+P NCP++ Y +M CW P++RPTF+ LR LED+F T+ Y
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQY 505
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 449 bits (1155), Expect = e-126
Identities = 233/466 (50%), Positives = 314/466 (67%), Gaps = 23/466 (4%)
Query: 38 PQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQ 97
P S + +AL Y+ DL F G++L++L+ E WW A+ L ++G
Sbjct: 57 PASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGE-WWKAQSLTTGQEG------ 109
Query: 98 GYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL 157
+IP N+VA+ SL+ EPWFF + R DAE+QLL N GSFLIRESES G FSLSV
Sbjct: 110 -FIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVR 168
Query: 158 D-----GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQ 212
D G VVKHY+I+ LD GGF+++ R F L+E V HYT SDGLC +L +PC +
Sbjct: 169 DFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQK 228
Query: 213 VPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN 272
P+ D+WE+ R +++L++RLG+GQFGEVW G +N T VAVK+LK GSM P+
Sbjct: 229 PQKPW-----WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD 283
Query: 273 DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV 332
FL EA +MK L+H +L++LYAV T ++PIYIITE M +GSL ++L+ +G K+ + + +
Sbjct: 284 AFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLL 342
Query: 333 DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE 392
DMAAQ+A GMA++E RNYIHRDL A N+LV + K+ADFGLAR+ + DNE Y +R
Sbjct: 343 DMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNE--YTAREG 399
Query: 393 IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRL 452
K P+KWTAPEAI F+IKSDVWSFGILL EI+T+G++PY GMT +VIQ L + YR+
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
Query: 453 PQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497
+P NCP++ Y +M CW P++RPTF+ LR LED+F T+ Y
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQY 505
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 446 bits (1147), Expect = e-125
Identities = 229/452 (50%), Positives = 310/452 (68%), Gaps = 23/452 (5%)
Query: 45 HYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNY 104
H+ VAL+DY A DL G+KLQVL + WW AR L R+G Y+PSN+
Sbjct: 61 HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGD-WWLARSLVTGREG-------YVPSNF 112
Query: 105 VAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD----GA 160
VA SL+ E WFF + GR +AE+QLL NK GSFLIRESE+ KG FSLSV D G
Sbjct: 113 VARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGE 172
Query: 161 VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLS 220
++KHY+I+ LDEGG++++ R F +L V HY+K DGLC +L PC++ PAP +
Sbjct: 173 LIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVR---PAPQNPW 229
Query: 221 YKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQI 280
+ D+WEI R S++L+++LGSGQFGEVW G + N VA+KTLK G+M P FL EA +
Sbjct: 230 AQ--DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANV 287
Query: 281 MKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVAS 340
MK L+H +L++LYAV T E PIYI+TE M G L ++L+ D GS++ L + +DM+AQ+A
Sbjct: 288 MKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAE 346
Query: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400
GMAY+E N IHRDL A N+LV E K+ADFGLAR+ +D+E Y ++ K P+KWT
Sbjct: 347 GMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARI--IDSE--YTAQEGAKFPIKWT 402
Query: 401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQ 460
APEAI F+IK+DVWSFG+LL E++TYG++PY GM+ +VI+ L + YR+P+P CP
Sbjct: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
Query: 461 QFY-NIMLECWNAEPKERPTFETLRWKLEDYF 491
+ Y ++ ECW + P+ERPTFE L+ LED++
Sbjct: 463 ELYRGVIAECWRSRPEERPTFEFLQSVLEDFY 494
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 380 bits (975), Expect = e-105
Identities = 198/466 (42%), Positives = 286/466 (61%), Gaps = 16/466 (3%)
Query: 35 LCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQ 94
L + S+ + FVAL+D+ A LS G+KL+VL H G W + ++
Sbjct: 54 LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC--------EAQTK 105
Query: 95 QLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSL 154
QG++PSNY+ SL+ W+ G + R+ AE L S GSFL+RESES G+ S+
Sbjct: 106 NGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSI 163
Query: 155 SVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVP 214
S+ V HYRI +G +++ F+TL E V H++ +DGL L P K P
Sbjct: 164 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKP 223
Query: 215 APFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPND 273
+ +S D+WE++R I + +LG GQ+GEV+EG+W + VAVKTLK +M+ +
Sbjct: 224 TVYGVS-PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE 282
Query: 274 FLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD 333
FL+EA +MK ++HP L+QL VCT E P YIITE M +G+L +YL+ +++ +
Sbjct: 283 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 342
Query: 334 MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEI 393
MA Q++S M YLE +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y +
Sbjct: 343 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---TGDTYTAHAGA 399
Query: 394 KLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLP 453
K P+KWTAPE++ NKFSIKSDVW+FG+LL+EI TYG PY G+ +QV ++L ++YR+
Sbjct: 400 KFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRME 459
Query: 454 QPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
+P CP++ Y +M CW P +RP+F + E F+ +SS SD
Sbjct: 460 RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ-ESSISD 504
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 380 bits (975), Expect = e-105
Identities = 198/466 (42%), Positives = 286/466 (61%), Gaps = 16/466 (3%)
Query: 35 LCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQ 94
L + S+ + FVAL+D+ A LS G+KL+VL H G W + ++
Sbjct: 73 LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC--------EAQTK 124
Query: 95 QLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSL 154
QG++PSNY+ SL+ W+ G + R+ AE L S GSFL+RESES G+ S+
Sbjct: 125 NGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSI 182
Query: 155 SVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVP 214
S+ V HYRI +G +++ F+TL E V H++ +DGL L P K P
Sbjct: 183 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKP 242
Query: 215 APFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPND 273
+ +S D+WE++R I + +LG GQ+GEV+EG+W + VAVKTLK +M+ +
Sbjct: 243 TVYGVS-PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE 301
Query: 274 FLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD 333
FL+EA +MK ++HP L+QL VCT E P YIITE M +G+L +YL+ +++ +
Sbjct: 302 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 361
Query: 334 MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEI 393
MA Q++S M YLE +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y +
Sbjct: 362 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---TGDTYTAHAGA 418
Query: 394 KLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLP 453
K P+KWTAPE++ NKFSIKSDVW+FG+LL+EI TYG PY G+ +QV ++L ++YR+
Sbjct: 419 KFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRME 478
Query: 454 QPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
+P CP++ Y +M CW P +RP+F + E F+ +SS SD
Sbjct: 479 RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ-ESSISD 523
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 378 bits (970), Expect = e-105
Identities = 204/458 (44%), Positives = 278/458 (60%), Gaps = 24/458 (5%)
Query: 32 PGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDG 91
P CSP Q F+AL+D+ AR +LS R GD+L L+ G+ FAR L
Sbjct: 45 PAEPCSPFPQ----LFLALYDFTARCGGELSVRRGDRLCALEE-GGGYIFARRL------ 93
Query: 92 SSQQLQGYIPSNYVAE--DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQK 149
S Q G +P +VA+ +L +PW+F + R+ A++ LL N+ G+FLIR SES
Sbjct: 94 SGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSL 153
Query: 150 GEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCL 209
G +SLSV A V HYR+ +G +L + R+F L E +++Y + L +PC+
Sbjct: 154 GGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM 213
Query: 210 KIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSM 269
+ P D WE + L ++LG G FGEVWEGLW + PVA+K +K +M
Sbjct: 214 PQKAPRQ--------DVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANM 265
Query: 270 DPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLT 329
D +E Q +K LRH +LI+L+AVC+ +P+YI+TELMR G+LQ +L G + L
Sbjct: 266 KLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLP 325
Query: 330 QQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYES 389
+ A QVA GM+YLE + +HRDLAARNVLV + KVADFGLAR+ K +DIY
Sbjct: 326 PLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLK---DDIYSP 382
Query: 390 RHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN 449
K+PVKWTAPEA FS KSDVWSFG+LL+E+ TYG+ PY GMT + +Q + +
Sbjct: 383 SSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRG 442
Query: 450 YRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKL 487
YRLP+P+ CP + Y +MLECW + P+ERP+F TLR KL
Sbjct: 443 YRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 374 bits (960), Expect = e-103
Identities = 209/457 (45%), Positives = 270/457 (59%), Gaps = 63/457 (13%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+DY+ART +DLSF G+K Q+L++ WW AR L G YIPSNYVA
Sbjct: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETG-------YIPSNYVA 139
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
S+QAE W+FG +GR DAE+QLL N G+FLIRESE+ KG +SLS+ D +K
Sbjct: 140 PVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMK--- 196
Query: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
+ V HY KL I A F+ + V
Sbjct: 197 --------------------GDHVKHYKIR------KLDNGGYYITTRAQFETLQQLVQH 230
Query: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRH 286
+ G WN T VA+KTLKPG+M P FL EAQIMK L+H
Sbjct: 231 YS----------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 268
Query: 287 PKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLE 346
KL+QLYAV + E+PIYI+TE M GSL ++L++ G + L VDMAAQVA+GMAY+E
Sbjct: 269 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 327
Query: 347 SRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIR 406
NYIHRDL + N+LVG I K+ADFGLAR+ + DNE Y +R K P+KWTAPEA
Sbjct: 328 RMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTAPEAAL 384
Query: 407 SNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIM 466
+F+IKSDVWSFGILL E++T G++PY GM +V++ + + YR+P P +CP + +M
Sbjct: 385 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 444
Query: 467 LECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
+ CW +P+ERPTFE L+ LEDYF T+ Y N
Sbjct: 445 IHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 481
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 370 bits (951), Expect = e-102
Identities = 201/454 (44%), Positives = 281/454 (61%), Gaps = 15/454 (3%)
Query: 39 QSQRH-GHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQ 97
+ Q H G +V L+D+++RT E+LSFRAGD V E WW+A L+ + Q
Sbjct: 4 RDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARK-EEQWWWATLLD---EAGGAVAQ 59
Query: 98 GYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL 157
GY+P NY+AE ++++EPWFFG I RS+A ++L N TG+FLIR SE ++ LSV
Sbjct: 60 GYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVR 119
Query: 158 DGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPF 217
D V+HY+I R G L F +L E V+++ S ++L PC K + P P
Sbjct: 120 DTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHE-PEPL 178
Query: 218 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR- 276
D WE R L ++LGSG FGEV+EGLW + VA+K + ++ L+
Sbjct: 179 P----HWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQS 234
Query: 277 EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAA 336
E Q MK LRH ++ LYAV ++ DP+YIITELM GSL E L++ + +++ +D+A
Sbjct: 235 EIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAW 294
Query: 337 QVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLP 396
QVA GM YLES+NYIHRDLAARN+LVGE+ + KV DFGLAR+ K ED+Y S H+ +P
Sbjct: 295 QVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIK---EDVYLS-HDHNIP 350
Query: 397 VKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPS 456
KWTAPEA+ +S KSDVWSFGILL+E+ + G++PY GM+ + + YR+P P
Sbjct: 351 YKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPL 410
Query: 457 NCPQQFYNIMLECWNAEPKERPTFETLRWKLEDY 490
CP + +ML CW +P++RP F+ LR +L +
Sbjct: 411 ECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSF 444
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 97 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 148
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 265
Query: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 266 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 325
Query: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
Query: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 442
Query: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 502
Query: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
M CW P +RP+F E F DSS S+
Sbjct: 503 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 535
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 163
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 164 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 221
Query: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 280
Query: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 340
Query: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400
Query: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 457
Query: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 517
Query: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
M CW P +RP+F E F DSS S+
Sbjct: 518 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 550
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 91 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 142
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 143 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 200
Query: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 259
Query: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 260 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 319
Query: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 320 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 379
Query: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 380 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 436
Query: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 437 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 496
Query: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
M CW P +RP+F E F DSS S+
Sbjct: 497 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 529
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 97 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 148
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 265
Query: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 266 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 325
Query: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
Query: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 442
Query: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 502
Query: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
M CW P +RP+F E F DSS S+
Sbjct: 503 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 535
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 76 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 127
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 128 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 185
Query: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 244
Query: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 245 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 304
Query: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 305 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 364
Query: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 365 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 421
Query: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 422 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 481
Query: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
M CW P +RP+F E F DSS S+
Sbjct: 482 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 514
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 324 bits (831), Expect = 1e-88
Identities = 185/473 (39%), Positives = 274/473 (57%), Gaps = 26/473 (5%)
Query: 32 PGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDG 91
P +P S VAL+DY A DL R GD+ +L+ + WW AR D
Sbjct: 204 PEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRAR------DK 257
Query: 92 SSQQLQGYIPSNYVAE-DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKG 150
+ Q+ GYIPSNYV E + S++ W+ + RS AE QLL E K G F++R+S S+ G
Sbjct: 258 NGQE--GYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDS-SKAG 313
Query: 151 EFSLSVLDGA------VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKL 204
++++SV + V++HY + + ++L + +FST+ E ++++ S GL +L
Sbjct: 314 KYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRL 373
Query: 205 GKPCLKIQVPAPFD--LSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVK 262
P + AP L Y + WEID + LK LG+GQFG V G W VA+K
Sbjct: 374 KYPVSQQNKNAPSTAGLGYGS---WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIK 430
Query: 263 TLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDT 322
+K GSM ++F+ EA++M NL H KL+QLY VCT + PI+IITE M +G L YL+ +
Sbjct: 431 MIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EM 489
Query: 323 GSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVD 382
+ Q ++M V M YLES+ ++HRDLAARN LV + + KV+DFGL+R + +D
Sbjct: 490 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLD 548
Query: 383 NEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQV 442
+E Y S K PV+W+ PE + +KFS KSD+W+FG+L++EI + GKMPY T ++
Sbjct: 549 DE--YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSET 606
Query: 443 IQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDS 495
+ +AQ RL +P ++ Y IM CW+ + ERPTF+ L + D + +S
Sbjct: 607 AEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 659
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 315 bits (807), Expect = 6e-86
Identities = 173/455 (38%), Positives = 263/455 (57%), Gaps = 27/455 (5%)
Query: 49 ALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAED 108
AL+D+ R +L+ R ++ +L+ + WW AR R G+ +G IPSNYV E+
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD----RLGN----EGLIPSNYVTEN 140
Query: 109 R--SLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGA------ 160
+ +L+ W+ I R+ AE LL E+K G+F++R+S G +++SV GA
Sbjct: 141 KITNLEIYEWYHRNITRNQAE-HLLRQESKEGAFIVRDSR-HLGSYTISVFMGARRSTEA 198
Query: 161 VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPC--LKIQVPAPFD 218
+KHY+IK+ D G +++ R F ++ E + ++ + GL +L P + +PA
Sbjct: 199 AIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAG 258
Query: 219 LSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREA 278
SY ++WEID + + +K +GSGQFG V G W + VA+K + GSM DF+ EA
Sbjct: 259 FSY---EKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEA 315
Query: 279 QIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQV 338
++M L H KL+QLY VC P+YI+TE M +G L YL+ + G K+ + + +
Sbjct: 316 KVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVCQDI 374
Query: 339 ASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK 398
GM YLE YIHRDLAARN LV I K++DFG+ R + +D+E Y S K P+K
Sbjct: 375 CEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTR-YVLDDE--YVSSFGAKFPIK 431
Query: 399 WTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNC 458
W+ PE NK+S KSDVWSFG+L++E+ T GKMP+ + QV++ +++ +RL +P
Sbjct: 432 WSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLA 491
Query: 459 PQQFYNIMLECWNAEPKERPTFETLRWKLEDYFET 493
P Y +M CW+ +P+ RPTF L + + ET
Sbjct: 492 PMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAET 526
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 304 bits (778), Expect = 1e-82
Identities = 173/462 (37%), Positives = 257/462 (55%), Gaps = 29/462 (6%)
Query: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
VA++D+QA DL G + +L+ WW AR + G+ +GYIPSNYV
Sbjct: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD----KYGN----EGYIPSNYVTG 236
Query: 108 DRS--LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD------G 159
+S L W+ + RS AE QLL SE+K G F++R+S SQ G +++S+
Sbjct: 237 KKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGS 294
Query: 160 AVVKHYRIKRLDEGG--FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPF 217
+ +HY IK ++L + F ++ E + ++ + GL +L P AP
Sbjct: 295 SGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPT 354
Query: 218 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLRE 277
+ + ++WEI+ + + ++ LGSG FG V G W VA+K ++ G+M DF+ E
Sbjct: 355 TAGF-SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEE 413
Query: 278 AQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV--DMA 335
A++M L HPKL+QLY VCT + PIYI+TE M G L +L+ G H ++ V M
Sbjct: 414 AKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG---HFSRDVLLSMC 470
Query: 336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL 395
V GM YLE ++IHRDLAARN LV E + KV+DFG+AR +D Y S K
Sbjct: 471 QDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVL---DDQYTSSSGAKF 527
Query: 396 PVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP 455
PVKW PE ++FS KSDVWSFG+L++E+ T G+MP+ T +V+ M+ + +RL QP
Sbjct: 528 PVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQP 587
Query: 456 SNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSY 497
Y +ML CW +P+ RP+FE L +++ E + ++
Sbjct: 588 KLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETF 629
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 296 bits (759), Expect = 2e-80
Identities = 166/457 (36%), Positives = 258/457 (56%), Gaps = 26/457 (5%)
Query: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
+AL+DYQ ++L+ R ++ +LD+ WW + R+G +GY+PS+Y+ E
Sbjct: 177 IALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD----RNGH----EGYVPSSYLVE 228
Query: 108 D--RSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVV--- 162
+L+ W+ +I R AEK LL K G+F++R+S + G +++SV AVV
Sbjct: 229 KSPNNLETYEWYNKSISRDKAEK-LLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSEN 286
Query: 163 ----KHYRIKRLDEGG--FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAP 216
KHY IK ++ +++ + +F ++ ++++ GL +L P + AP
Sbjct: 287 NPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAP 346
Query: 217 FDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR 276
+ +W ID + + ++ +GSGQFG V G W N VA+KT++ G+M DF+
Sbjct: 347 VTAGLR-YGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIE 405
Query: 277 EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAA 336
EA++M L HPKL+QLY VC + PI ++ E M HG L +YL+ G T + M
Sbjct: 406 EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAET-LLGMCL 464
Query: 337 QVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLP 396
V GMAYLE IHRDLAARN LVGE+ + KV+DFG+ R F +D D Y S K P
Sbjct: 465 DVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLD--DQYTSSTGTKFP 521
Query: 397 VKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPS 456
VKW +PE +++S KSDVWSFG+L++E+ + GK+PY + ++V++ ++ +RL +P
Sbjct: 522 VKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPR 581
Query: 457 NCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFET 493
Y IM CW P++RP F L +L + E+
Sbjct: 582 LASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES 618
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 278 bits (710), Expect = 1e-74
Identities = 159/394 (40%), Positives = 221/394 (56%), Gaps = 13/394 (3%)
Query: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAV----- 161
E+ +L WF G I RS +E QLL + K G+F++R S SQ G +++S+ AV
Sbjct: 287 EEENLDDYDWFAGNISRSQSE-QLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKG 344
Query: 162 -VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLS 220
VKHY + E +L F ++ + + ++ S G+ +L P P +S
Sbjct: 345 TVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVS 404
Query: 221 YKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQI 280
WE+ R I LLK LGSGQFG V G W VAVK +K GSM ++F +EAQ
Sbjct: 405 LGN-GIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQT 463
Query: 281 MKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVAS 340
M L HPKL++ Y VC+ E PIYI+TE + +G L YL++ G + +Q ++M V
Sbjct: 464 MMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVCE 522
Query: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400
GMA+LES +IHRDLAARN LV KV+DFG+ R +D Y S K PVKW+
Sbjct: 523 GMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVL---DDQYVSSVGTKFPVKWS 579
Query: 401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQ 460
APE K+S KSDVW+FGIL++E+ + GK PY +QV+ ++Q +RL +P
Sbjct: 580 APEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASD 639
Query: 461 QFYNIMLECWNAEPKERPTFETLRWKLEDYFETD 494
Y IM CW+ P++RPTF+ L +E E D
Sbjct: 640 TIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKD 673
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,451,735
Number of Sequences: 37866
Number of extensions: 854533
Number of successful extensions: 4439
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 795
Number of HSP's successfully gapped in prelim test: 263
Number of HSP's that attempted gapping in prelim test: 1790
Number of HSP's gapped (non-prelim): 1325
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.