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Search of human proteins with 4503195
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503195 cytochrome P450, family 17 [Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 1024 0.0
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1... 249 5e-66
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 239 4e-63
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ... 231 2e-60
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 220 3e-57
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 213 3e-55
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide... 206 3e-53
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1... 202 4e-52
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 202 6e-52
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ... 201 1e-51
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ... 197 2e-50
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 197 2e-50
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ... 195 7e-50
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ... 192 5e-49
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide... 192 5e-49
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ... 190 2e-48
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ... 190 3e-48
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 186 6e-47
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ... 185 1e-46
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6... 182 5e-46
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ... 180 2e-45
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18... 174 2e-43
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ... 169 7e-42
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ... 144 1e-34
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ... 140 3e-33
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 122 1e-27
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 119 5e-27
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 119 7e-27
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 119 8e-27
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 119 8e-27
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 1024 bits (2648), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
Sbjct: 1 MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60
Query: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
Sbjct: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120
Query: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
Sbjct: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180
Query: 181 LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN 240
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
Sbjct: 181 LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN 240
Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
Sbjct: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300
Query: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
Sbjct: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360
Query: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
Sbjct: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420
Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480
Query: 481 KVVFLIDSFKVKIKVRQAWREAQAEGST 508
KVVFLIDSFKVKIKVRQAWREAQAEGST
Sbjct: 481 KVVFLIDSFKVKIKVRQAWREAQAEGST 508
>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
[Homo sapiens]
Length = 512
Score = 249 bits (635), Expect = 5e-66
Identities = 152/459 (33%), Positives = 241/459 (52%), Gaps = 25/459 (5%)
Query: 24 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 83
G K P PL+G + L ++ H+ + ++ ++YG + +R+G+ V++ +
Sbjct: 36 GLKNPPGPWGWPLIGHMLTLGKNPHLALS--RMSQQYGDVLQIRIGSTPVVVLSGLDTIR 93
Query: 84 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALFKDGDQ 140
+ L+++G DF GRP + T + SN + DSG W RRLA + +F++ D
Sbjct: 94 QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153
Query: 141 K----LEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGD 192
LE+ + +E ISTL +++A G + V V+VTNVI ICF Y +
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGP-GHFNPYRY-VVVSVTNVICAICFGRRYDHNH 211
Query: 193 PELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKE 252
EL + N N + + + D +P L+ PN +L K + + K+++ + +
Sbjct: 212 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271
Query: 253 KFRSDSITNMLDTLM---QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309
F I ++ D+L+ Q K +N N LSD I+ + D+FGAG +T T+
Sbjct: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQ-------LSDEKIINIVLDLFGAGFDTVTT 324
Query: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 369
+ W+L +L+ NP+V++K+ EE+D +G SR P +SDR+ L +EA I E R P
Sbjct: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384
Query: 370 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 429
IPH D+S+ F + KG V +N W ++H++K W P +F+PERFL P G S
Sbjct: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444
Query: 430 VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468
+ FG G R CIGE +AR E+FL +A LLQR + VP
Sbjct: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 239 bits (610), Expect = 4e-63
Identities = 147/454 (32%), Positives = 240/454 (52%), Gaps = 34/454 (7%)
Query: 56 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 115
L +K+GPIY + +G + V++ + +E ++KK DF+GRP+ T + S N ++
Sbjct: 52 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111
Query: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175
D W+ H++L + AL +E ++ Q C+ + G + I +
Sbjct: 112 DYSLLWKAHKKLTRS--ALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 169
Query: 176 TNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDS-----LVDLVPWLKIFPNKTLE 230
++I + F K+ N++ Y + I + L S +VD++P+L+ FPN L
Sbjct: 170 CSIICYLTFGDKIKDD----NLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLR 225
Query: 231 KLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP--DQDSELLS 288
+LK ++ R+ ++ L +KE + +M+D ++Q G A P ++ S L
Sbjct: 226 RLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQ-------GVAQPSMEEGSGQLL 278
Query: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG----FSRTPTI 344
+ H+ D+ G ETT + + W + FLLH+P+++++L EE+D +G SR P
Sbjct: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-Y 337
Query: 345 SDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEK 404
DR RL LL ATI EVLRLRPV P+ +PH+ SSI + + +GT +I NL H +E
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397
Query: 405 EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464
W +P +F P+RFL P + L FG G R C+GE LAR ELF+++ LLQ F
Sbjct: 398 VWERPHEFWPDRFLEP------GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFT 451
Query: 465 LEVPDDGQLPSLEGIP--KVVFLIDSFKVKIKVR 496
L +P LPSL+ +P V+ + F+V+++ R
Sbjct: 452 L-LPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
[Homo sapiens]
Length = 516
Score = 231 bits (588), Expect = 2e-60
Identities = 138/458 (30%), Positives = 240/458 (52%), Gaps = 24/458 (5%)
Query: 24 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 83
G K P PL+G + L ++ H+ + ++ ++YG + +R+G+ +++ +
Sbjct: 38 GLKSPPEPWGWPLLGHVLTLGKNPHLALS--RMSQRYGDVLQIRIGSTPVLVLSRLDTIR 95
Query: 84 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALFKDGDQ 140
+ L+++G DF GRP + T + ++ + DSG W RRLA + TF++ D
Sbjct: 96 QALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155
Query: 141 K----LEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSY-KNG 191
LE+ + +E IS L +++A D V V+V NVI +CF + ++
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMAGPG--HFDPYNQVVVSVANVIGAMCFGQHFPESS 213
Query: 192 DPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYK 251
D L++++N +E ++ S + +D P L+ PN L++ K+ + L K ++ +
Sbjct: 214 DEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHY 272
Query: 252 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 311
+ F +S+ ++ L + + GP L+ I+ + DIFGAG +T T+ +
Sbjct: 273 QDFDKNSVRDITGALFK------HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 326
Query: 312 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLI 371
W+L +L+ P++++K+ +E+D +G R P +SDR +L LEA I E R P I
Sbjct: 327 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 386
Query: 372 PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP-SV 430
PH D+++ F + K V +N W ++H+ + W P +F PERFL GT + P S
Sbjct: 387 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446
Query: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468
+ FG G R CIGE+LA+ E+FL +A LLQ+ + VP
Sbjct: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 220 bits (560), Expect = 3e-57
Identities = 148/500 (29%), Positives = 248/500 (49%), Gaps = 36/500 (7%)
Query: 6 ALLLLTLAYLF---WPKRRCPGAKYPKSLLSLPLVGSL------PFLPRHGHMHNN---- 52
ALLL L L W +RR P PLVG+ PFL R + +
Sbjct: 36 ALLLCGLVALLGWSWLRRR-RARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAA 94
Query: 53 ------------FFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMA 100
L + YG I+S +G V++ +E L+++ + FS RP++
Sbjct: 95 GIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVP 154
Query: 101 TLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH 160
+ I + KG+ FA G W+ R+ + +T F G LE I +E + + H
Sbjct: 155 LISIVTKE-KGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKH 213
Query: 161 NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNY-NEGIIDNL-SKDSLVDLV 218
+ AV+N+I +CF + + E + + + G+ L S+ LV++
Sbjct: 214 GEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNIC 273
Query: 219 PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNA 278
PWL P ++L+ K L KI+++++E ++ + +D + N+
Sbjct: 274 PWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNS 333
Query: 279 GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGF 338
D E ++ IGD+F AG +TTT+ + W L ++ NP V++K++EEI++ +G
Sbjct: 334 NSSFDEE-----YLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGA 388
Query: 339 SRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA 398
+R P+++D+ ++ EATI EV RL V P+ IPH + ++ + + + KGT ++ NLW+
Sbjct: 389 NRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWS 448
Query: 399 LHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAW 458
+H + W +P+ F P RFL+ G QLI +++PFG G R C+GE LA+ ELFL+
Sbjct: 449 VHRDPAIWEKPEDFYPNRFLDDQG-QLIKKE-TFIPFGIGKRVCMGEQLAKMELFLMFVS 506
Query: 459 LLQRFDLEVPDDGQLPSLEG 478
L+Q F +P+D + P L G
Sbjct: 507 LMQSFAFALPEDSKKPLLTG 526
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 213 bits (542), Expect = 3e-55
Identities = 134/467 (28%), Positives = 242/467 (51%), Gaps = 13/467 (2%)
Query: 7 LLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKK-YGPIYS 65
LLL L K+R P +P LP +G++ L + + + + Q + YG I+S
Sbjct: 20 LLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFS 78
Query: 66 VRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHR 125
+ +G +TV++ + + KE L+ + + F+ RP + L + G+ + G W HR
Sbjct: 79 LDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLP-LFMKMTKMGGLLNSRYGRGWVDHR 137
Query: 126 RLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFN 185
RLA+ +F F G + E I +E D + T+ G+ D + AV+N+ +LI F
Sbjct: 138 RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFG 197
Query: 186 TSYKNGDPEL-NVIQNYNEGI-IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243
+ D + ++I+ ++E + + + L + PW+ I P ++L + + D L
Sbjct: 198 ERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFL 257
Query: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAG 303
++++E + + +D + D + G + S S +++ ++G++ AG
Sbjct: 258 SRLIEKASVNRKPQLPQHFVDAYL------DEMDQGKNDPSSTFSKENLIFSVGELIIAG 311
Query: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363
ETTT+V++W + F+ P ++ ++ +EID +G + P+ D+ ++ EA + EVLR
Sbjct: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371
Query: 364 RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT 423
+ P+ I H + D+ + +++ KGT VI NL+++H +EK W P+ F PERFL+ +G
Sbjct: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG- 430
Query: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
+ + +PF G R C+GE LAR E+FL LLQRF L P +
Sbjct: 431 -YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 476
>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
[Homo sapiens]
Length = 543
Score = 206 bits (525), Expect = 3e-53
Identities = 132/484 (27%), Positives = 234/484 (48%), Gaps = 22/484 (4%)
Query: 28 PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 87
P + PL+G+ + + H+ +F +L ++YG ++ +R+G+ V++ + + L+
Sbjct: 51 PPGPFAWPLIGNAAAVGQAAHL--SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALV 108
Query: 88 KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF----KDGDQKLE 143
++G F+ RP A+ + S R +AF HW++ RR A + F Q LE
Sbjct: 109 QQGSAFADRPAFASFRVVSGGRS-MAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLE 167
Query: 144 KIICQEISTLCDMLA--THNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNY 201
+ E L +L + +G +D VAV NV+S +CF Y + DPE + ++
Sbjct: 168 GHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSH 227
Query: 202 NEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRS----D 257
NE + SLVD++PWL+ FPN + ++ + N IL+ + S
Sbjct: 228 NEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGA 287
Query: 258 SITNMLDTLM---QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314
+ +M+D + + K D+ G D E ++ TI DIFGA +T ++ ++W
Sbjct: 288 APRDMMDAFILSAEKKAAGDSHGGGARLDLE-----NVPATITDIFGASQDTLSTALQWL 342
Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374
L P V+ ++ E+DQ VG R P + D+ L + A + E +R P+ IPH
Sbjct: 343 LLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHA 402
Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434
++S+ + + K T V +N W+++H+ +W P+ F P RFL+ G + +
Sbjct: 403 TTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMI 462
Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIK 494
F G R CIGE L++ +LFL ++ L + D + + + + SFKV +
Sbjct: 463 FSVGKRRCIGEELSKMQLFLFISILAHQCDFRA-NPNEPAKMNFSYGLTIKPKSFKVNVT 521
Query: 495 VRQA 498
+R++
Sbjct: 522 LRES 525
>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
[Homo sapiens]
Length = 490
Score = 202 bits (515), Expect = 4e-52
Identities = 141/474 (29%), Positives = 240/474 (50%), Gaps = 36/474 (7%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63
L LLLL++ W + G K P LP++G++ + + + L K YGP+
Sbjct: 11 LSCLLLLSI----WRQSSGRG-KLPPGPTPLPVIGNILQIDIKD-VSKSLTNLSKIYGPV 64
Query: 64 YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123
+++ G + V++ +++ KE LI G++FSGR + A N GI F++ G W+
Sbjct: 65 FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERA-NRGFGIVFSN-GKRWKE 122
Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183
RR ++ T F G + +E + +E L + L D +F + A NVI I
Sbjct: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182
Query: 184 FNTSYKNGDPE-LNVIQNYNEGIIDNLSKDSLVDLVPWLKI----------FPNKTLEKL 232
F + D + LN+++ NE I + PW++I FP + L
Sbjct: 183 FQKRFDYKDQQFLNLMEKLNENI--------RIVSTPWIQICNNFPTIIDYFPGTHNKLL 234
Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
K+ + +D+L K+ E ++E ++ + +D + KM + N Q SE +N +
Sbjct: 235 KNLAFMESDILEKVKE-HQESMDINNPRDFIDCFL-IKMEKEKQN----QQSEFTIENLV 288
Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
+T D+ GAG ETT++ +++ L LL +P+V K+ EEI++ +G +R+P + DR +
Sbjct: 289 ITA-ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPY 347
Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
+A + EV R + P +PH D + + KGT ++ +L ++ H+ KE+ P+ F
Sbjct: 348 TDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMF 407
Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
P FL+ G S ++PF AG R C+GE LAR ELFL + ++LQ F+L+
Sbjct: 408 DPRHFLDEGGN--FKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 202 bits (514), Expect = 6e-52
Identities = 137/454 (30%), Positives = 223/454 (49%), Gaps = 64/454 (14%)
Query: 56 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 115
L +K+GPIY + +G + ++ S N ++
Sbjct: 52 LTQKFGPIYRLHLGLQDKLV------------------------------SRNYPDLSLG 81
Query: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175
D W+ H++L + AL +E ++ Q C+ + G + I +
Sbjct: 82 DYSLLWKAHKKLTRS--ALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 139
Query: 176 TNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDS-----LVDLVPWLKIFPNKTLE 230
++I + F K+ N++ Y + I + L S +VD++P+L+ FPN L
Sbjct: 140 CSIICYLTFGDKIKDD----NLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLR 195
Query: 231 KLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP--DQDSELLS 288
+LK ++ R+ ++ L +KE + +M+D ++Q G A P ++ S L
Sbjct: 196 RLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQ-------GVAQPSMEEGSGQLL 248
Query: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG----FSRTPTI 344
+ H+ D+ G ETT + + W + FLLH+P+++++L EE+D +G SR P
Sbjct: 249 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-Y 307
Query: 345 SDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEK 404
DR RL LL ATI EVLRLRPV P+ +PH+ SSI + + +GT +I NL H +E
Sbjct: 308 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 367
Query: 405 EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464
W +P +F P+RFL P + L FG G R C+GE LAR ELF+++ LLQ F
Sbjct: 368 VWERPHEFWPDRFLEP------GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFT 421
Query: 465 LEVPDDGQLPSLEGIP--KVVFLIDSFKVKIKVR 496
L +P LPSL+ +P V+ + F+V+++ R
Sbjct: 422 L-LPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 454
>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 1 [Homo sapiens]
Length = 490
Score = 201 bits (511), Expect = 1e-51
Identities = 147/475 (30%), Positives = 240/475 (50%), Gaps = 33/475 (6%)
Query: 5 VALLL-LTLAYLFWPKRRCPG-AKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGP 62
VAL+L L+ +L R+ G + P LP++G++ L M + K YGP
Sbjct: 5 VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKD-MSKSLTNFSKVYGP 63
Query: 63 IYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-GAHW 121
+++V G K V++ ++ KE LI G++FSGR + +A KG+ S G W
Sbjct: 64 VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGR---GSFPVAEKVNKGLGILFSNGKRW 120
Query: 122 QLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISL 181
+ RR + T F G + +E + +E L + L N D +F + A NVI
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
Query: 182 ICFNTSYKNGDPE-LNVIQNYNEGIIDNLSKDSLVDLVPWLKI---FPNKTLEKLKSHVK 237
+ F+ + D LN+++ +NE + S PW+++ FP SH K
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSS--------PWIQVCNNFPALIDYLPGSHNK 232
Query: 238 IRND---LLNKILENYKEKFRS---DSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNH 291
I + + + +LE KE S +S + +D + KM + N Q SE ++
Sbjct: 233 IAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFL-IKMEQEKHN----QQSEFTVES- 286
Query: 292 ILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLL 351
++ T+ D+FGAG ETT++ +++ L LL P+V K+ EEI+ VG +R+P + DR+ +
Sbjct: 287 LIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP 346
Query: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQ 411
+A + E+ R + P +PH D + + KGT +I +L ++ HN+KE+ P+
Sbjct: 347 YTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEM 406
Query: 412 FMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
F P FL+ +G S ++PF AG R C+GE LAR ELFL + +LQ F+L+
Sbjct: 407 FDPGHFLDKSGN--FKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK 459
>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
[Homo sapiens]
Length = 490
Score = 197 bits (500), Expect = 2e-50
Identities = 143/474 (30%), Positives = 240/474 (50%), Gaps = 36/474 (7%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63
L LLLL+L W + G K P LP++G++ + + + L K YGP+
Sbjct: 11 LSCLLLLSL----WRQSSGRG-KLPPGPTPLPVIGNILQIGIKD-ISKSLTNLSKVYGPV 64
Query: 64 YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123
+++ G K V++ ++ KE LI G++FSGR + A N GI F++ G W+
Sbjct: 65 FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERA-NRGFGIVFSN-GKKWKE 122
Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183
RR ++ T F G + +E + +E L + L D +F + A NVI I
Sbjct: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182
Query: 184 FNTSYKNGDPE-LNVIQNYNEGIIDNLSKDSLVDLVPWLKI----------FPNKTLEKL 232
F+ + D + LN+++ NE I S PW++I FP + L
Sbjct: 183 FHKRFDYKDQQFLNLMEKLNENIKILSS--------PWIQICNNFSPIIDYFPGTHNKLL 234
Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
K+ +++ +L K+ E ++E ++ + +D + KM + N Q SE ++ +
Sbjct: 235 KNVAFMKSYILEKVKE-HQESMDMNNPQDFIDCFLM-KMEKEKHN----QPSEFTIES-L 287
Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
T D+FGAG ETT++ +++ L LL +P+V K+ EEI++ +G +R+P + DR+ +
Sbjct: 288 ENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347
Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
+A + EV R + P +PH D + + KGT ++I+L ++ H+ KE+ P+ F
Sbjct: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 407
Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
P FL+ G S ++PF AG R C+GE LA ELFL + +LQ F+L+
Sbjct: 408 DPHHFLDEGGN--FKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 197 bits (500), Expect = 2e-50
Identities = 135/481 (28%), Positives = 236/481 (49%), Gaps = 21/481 (4%)
Query: 1 MWELV---ALLLLTLAYLF---WPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFF 54
+W +V LLL T+A+L + KRR P YP LP +G+ FL H
Sbjct: 12 LWAVVHPRTLLLGTVAFLLAADFLKRRRP-KNYPPGPWRLPFLGNF-FLVDFEQSHLEVQ 69
Query: 55 KLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAF 114
KKYG ++S+ +G + V++ L KE LI ++F RP + +K
Sbjct: 70 LFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF--KKNGLI 127
Query: 115 ADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVA 174
SG W+ RR + F G + LE+ I +E L + + NGQ D F + A
Sbjct: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
Query: 175 VTNVISLICFNTSYKNGDPELNVIQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKL 232
V+N+I I F ++ D + + + ++ L ++ PW+ F + L
Sbjct: 188 VSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247
Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
S+ K ++ +++ +++ + + +D ++ +M+ GN S +N I
Sbjct: 248 FSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK-EMSKHTGNP----TSSFHEENLI 302
Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352
+T+ D+F AG ETT++ ++W L ++ P++++K+ EID+ +G + P+ + R +
Sbjct: 303 CSTL-DLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPY 361
Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412
A I EV R+ + P+ +P + VD+++ + + KGT ++ NL ALH + EW PD F
Sbjct: 362 TNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTF 421
Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQ 472
P+ FL +++PF G R+C+GE LAR ELF+ L+Q+F P++ +
Sbjct: 422 NPDHFLE---NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK 478
Query: 473 L 473
L
Sbjct: 479 L 479
>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
[Homo sapiens]
Length = 494
Score = 195 bits (496), Expect = 7e-50
Identities = 137/468 (29%), Positives = 238/468 (50%), Gaps = 16/468 (3%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63
L+A L + + W +R+ G K P LP +G+ L M+N+ K+ ++YGP+
Sbjct: 11 LLACLTVMVLMSVWRQRKSRG-KLPPGPTPLPFIGNYLQLNTE-QMYNSLMKISERYGPV 68
Query: 64 YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123
+++ +G + V++ H KE L+ + ++FSGR + AT D G+AF++ QL
Sbjct: 69 FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGY-GVAFSNGERAKQL 127
Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183
RR ++AT F G + +E+ I +E L D L +G +ID +F + V+NVIS I
Sbjct: 128 -RRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIV 186
Query: 184 FNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVKIRN 240
F + D E + G S L ++ +K P + K ++
Sbjct: 187 FGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE-LQGLE 245
Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300
D + K +E+ + +S + +D+ + +M + N ++E N ++TT+ ++F
Sbjct: 246 DFIAKKVEHNQRTLDPNSPRDFIDSFL-IRMQEEEKNP----NTEFYLKNLVMTTL-NLF 299
Query: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360
AG ET ++ +++ L+ +P+V+ K++EEID+ +G +R P DR ++ EA I E+
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEI 359
Query: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420
R + PM + H+ N D+ +F + KGTEV L ++ + + + P F P+ FL+
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468
G S +++PF G R C GE LAR ELFL ++Q F + P
Sbjct: 420 KGQ--FKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSP 465
>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
[Homo sapiens]
Length = 490
Score = 192 bits (489), Expect = 5e-49
Identities = 145/495 (29%), Positives = 239/495 (48%), Gaps = 23/495 (4%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63
LV L L + W ++ C K P LP++G++ + + +F K YGP+
Sbjct: 7 LVLCLSFMLLFSLW-RQSCRRRKLPPGPTPLPIIGNMLQIDVKD-ICKSFTNFSKVYGPV 64
Query: 64 YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-GAHWQ 122
++V G V+ ++ KE LI G++FSGR I+ KG+ S G W+
Sbjct: 65 FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGR---GNSPISQRITKGLGIISSNGKRWK 121
Query: 123 LHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLI 182
RR ++ T F G + +E + +E L + L D +F + A NVI +
Sbjct: 122 EIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSV 181
Query: 183 CFNTSYKNGDPE-LNVIQNYNEGI-IDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVKIR 239
F + D L +++ +NE I N + + P L FP + LK+ R
Sbjct: 182 VFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTR 241
Query: 240 NDLLNKILENYKEKFRSDSITNMLDTL--MQAKMNSDNGNAGPDQDSELLSDNHILTTIG 297
+ + K+ KE S + N D + KM + N Q SE +N ++ T+
Sbjct: 242 SYIREKV----KEHQASLDVNNPRDFIDCFLIKMEQEKDN----QKSEFNIEN-LVGTVA 292
Query: 298 DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATI 357
D+F AG ETT++ +++ L LL +P+V K+ EEID +G R+P + DR+ + +A +
Sbjct: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352
Query: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
E+ R + P +PH D+ + + KGT ++ L ++ H++KE+ P+ F P F
Sbjct: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412
Query: 418 LNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLE 477
L+ G S ++PF AG R C GE LAR ELFL + +LQ F+L+ DD + +
Sbjct: 413 LDKNGN--FKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTT 470
Query: 478 GIPK-VVFLIDSFKV 491
+ K +V L S+++
Sbjct: 471 AVTKGIVSLPPSYQI 485
>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
[Homo sapiens]
Length = 494
Score = 192 bits (489), Expect = 5e-49
Identities = 139/469 (29%), Positives = 240/469 (51%), Gaps = 19/469 (4%)
Query: 4 LVALLL-LTLAYLF--WPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60
LVALL+ LT+ L W +R+ G K P LP +G+ L M+N+ K+ ++Y
Sbjct: 8 LVALLVCLTVMVLMSVWQQRKSKG-KLPPGPTPLPFIGNYLQLNTE-QMYNSLMKISERY 65
Query: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120
GP++++ +G + V++ H +E L+ + ++FSGR + AT D G+ F++
Sbjct: 66 GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGY-GVVFSNGERA 124
Query: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180
QL RR ++AT F G + +E+ I +E L D L G +ID +F + V+NVIS
Sbjct: 125 KQL-RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVIS 183
Query: 181 LICFNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVK 237
I F + D E + GI + S L ++ +K P + + ++
Sbjct: 184 SIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL-LQ 242
Query: 238 IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIG 297
D + K +E+ + +S + +D+ + +M + N ++E N ++TT+
Sbjct: 243 GLEDFIAKKVEHNQRTLDPNSPRDFIDSFL-IRMQEEEKNP----NTEFYLKNLVMTTL- 296
Query: 298 DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATI 357
++F G ET ++ +++ L+ +P+V+ K++EEID+ +G +R P DR ++ +EA I
Sbjct: 297 NLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVI 356
Query: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
E+ R V PM + + D+ +F + KGTEV L ++ + + P F P+ F
Sbjct: 357 HEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHF 416
Query: 418 LNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
LN G S +++PF G R+C GE LAR ELFL ++Q F L+
Sbjct: 417 LNEKGQ--FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463
>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 1 [Homo sapiens]
Length = 497
Score = 190 bits (483), Expect = 2e-48
Identities = 134/483 (27%), Positives = 237/483 (49%), Gaps = 21/483 (4%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNN---FFKLQKKY 60
+VA+ LL + + +R+ A+YP L LP +G+L H N F +L++++
Sbjct: 12 IVAIFLLLVDLMH--RRQRWAARYPPGPLPLPGLGNL----LHVDFQNTPYCFDQLRRRF 65
Query: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS--NNRKGIAFADSG 118
G ++S+++ V++ +E L+ G+D + RP + I +G+ A G
Sbjct: 66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125
Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178
W+ RR +++T G + LE+ + +E + LC A H+G+ + + AV+NV
Sbjct: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185
Query: 179 ISLICFNTSYKNGDPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHV 236
I+ + ++ DP L ++ EG+ + +++ VP L P + L+
Sbjct: 186 IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQK 245
Query: 237 KIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTI 296
L +++L ++ + L A+M GN P+ +D ++ +
Sbjct: 246 AFLTQL-DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FNDENLCIVV 299
Query: 297 GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356
D+F AG+ TT++ + W L ++ +P V++++ +EID +G R P + D+ + A
Sbjct: 300 ADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAV 359
Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416
I EV R + P+ + H + D + F + KGT +I NL ++ +E W +P +F PE
Sbjct: 360 IHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH 419
Query: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476
FL+ G + P ++LPF AG R+C+GE LAR ELFL LLQ F VP PS
Sbjct: 420 FLDAQG-HFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH 477
Query: 477 EGI 479
G+
Sbjct: 478 HGV 480
>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
[Homo sapiens]
Length = 491
Score = 190 bits (482), Expect = 3e-48
Identities = 142/478 (29%), Positives = 236/478 (49%), Gaps = 18/478 (3%)
Query: 5 VALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIY 64
+ LLLL L L K P L ++G+L L M + KL K+YG +Y
Sbjct: 8 ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQD-MLTSLTKLSKEYGSMY 66
Query: 65 SVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQM-ATLDIASNNRKGIAFADSGAHWQL 123
+V +G + V++ +Q KE L+ +G++FSGR A + N GIAF+ SG W++
Sbjct: 67 TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGN--GIAFS-SGDRWKV 123
Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183
R+ ++ F G + +E+ I +E S L L G+ D +F + +V+N+I +
Sbjct: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183
Query: 184 FNTSYKNGDPEL-NVIQNYNEGI-IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRND 241
F + + D L +I+ N+ I + L D+ P L + +++ + K D
Sbjct: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
Query: 242 LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301
L+ + +++ S + + + KM + D S D ++TT +FG
Sbjct: 244 LIAHSVHDHQASLDPRSPRDFIQCFL-TKMAEEK----EDPLSHFHMDTLLMTTHNLLFG 298
Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361
G +T ++ + L+ P+V+ ++ EEID VG +R P + DR + +A I EV
Sbjct: 299 -GTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQ 357
Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421
R + PM +PH+ D++ F + KGT+VI L +H++ ++ P +F PE FL+
Sbjct: 358 RFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLD-- 415
Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE---VPDDGQLPSL 476
Q S +++PF AG R C+GE LAR ELFL + +LQ F L+ P+D L L
Sbjct: 416 ANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPL 473
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 186 bits (471), Expect = 6e-47
Identities = 135/449 (30%), Positives = 237/449 (52%), Gaps = 30/449 (6%)
Query: 28 PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 87
P LP++G+L F ++ +F +L +++GP++++ +G++ V++ ++ KE L+
Sbjct: 33 PPGPFPLPIIGNL-FQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91
Query: 88 KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147
+FSGR + ++ +GI F ++G W+ RR ++ T + G Q E I
Sbjct: 92 DYKDEFSGRGDLPAFH--AHRDRGIIF-NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQ 148
Query: 148 QEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LNVIQNYNEGII 206
+E L + L GQ D +F + A NVI+ I F + D + L ++ +NE
Sbjct: 149 REAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF- 207
Query: 207 DNLSKDSLVDLVPWLKIFPN--KTLEKLK-SHVK-IRN--DLLNKILENYKEKFRS---D 257
L+ PWL+++ N L L SH K I+N ++ + E KE +S +
Sbjct: 208 ------HLLS-TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260
Query: 258 SITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317
++ D L+ +M + +A L + + I T+ D+F AG ETT++ +++ L
Sbjct: 261 CPRDLTDCLL-VEMEKEKHSA-----ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLI 314
Query: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377
L+ P++++KL+EEID+ +G SR P I DR + ++A + E+ R + P +PH+A
Sbjct: 315 LMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATR 374
Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437
D+ + + KGT V+ L ++ ++ +E+ P++F PE FLN G S + PF
Sbjct: 375 DTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK--FKYSDYFKPFST 432
Query: 438 GPRSCIGEILARQELFLIMAWLLQRFDLE 466
G R C GE LAR ELFL++ +LQ F+L+
Sbjct: 433 GKRVCAGEGLARMELFLLLCAILQHFNLK 461
>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 1 [Homo sapiens]
Length = 494
Score = 185 bits (469), Expect = 1e-46
Identities = 132/466 (28%), Positives = 237/466 (50%), Gaps = 16/466 (3%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63
L+A L + + W +R+ G K P LP +G+ L H+ ++ K + YGP+
Sbjct: 11 LLACLTVMVLMSVWQQRKSRG-KLPPGPTPLPFIGNYLQLNTE-HICDSIMKFSECYGPV 68
Query: 64 YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123
+++ +G + V++ H +E L+ + ++FSGR + AT D G+AF++ QL
Sbjct: 69 FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGY-GVAFSNGERAKQL 127
Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183
R A+AT F G + +E+ I +E L + + + +G +ID +F + V+NVIS I
Sbjct: 128 -LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIV 186
Query: 184 FNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVKIRN 240
F + D E + + GI + S L ++ +K P + K ++
Sbjct: 187 FGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL-LQGLE 245
Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300
D + K +E+ + +S + +D+ + M + N ++E N +++T+ ++F
Sbjct: 246 DFIAKKVEHNQRTLDPNSPQDFIDSFL-IHMQEEEKNP----NTEFYLKNLMMSTL-NLF 299
Query: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360
AG ET ++ +++ L+ +P+V+ K++EEID+ +G +R P DR ++ +EA I E+
Sbjct: 300 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEI 359
Query: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420
R V PM + + D+ +F + KGTEV L ++ + + P F P+ FL+
Sbjct: 360 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDD 419
Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
G S +++PF G R+C GE LAR ELFL ++Q F L+
Sbjct: 420 KGQ--FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463
>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
[Homo sapiens]
Length = 491
Score = 182 bits (463), Expect = 5e-46
Identities = 138/473 (29%), Positives = 231/473 (48%), Gaps = 19/473 (4%)
Query: 3 ELVALLLLTL--AYLFWPKRRCPGA--KYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58
EL LL L L L +R P + P LPL+G+L + R G + +F + ++
Sbjct: 2 ELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLL-KSFLRFRE 60
Query: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118
KYG +++V +G + V++ + +E L+ K + FSGR ++A +D G+ FA+ G
Sbjct: 61 KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGY-GVIFAN-G 118
Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178
W++ RR ++ T F G + +E+ I +E L + L G +D +F N+
Sbjct: 119 NRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANI 178
Query: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK--DSLVDLVP-WLKIFPNKTLEKLKSH 235
I I F + D E + N +S L +L +LK FP + K+
Sbjct: 179 ICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238
Query: 236 VKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTT 295
+I N + +E ++E + +++DT + M + NA SE N L T
Sbjct: 239 QEI-NAYIGHSVEKHRETLDPSAPKDLIDTYL-LHMEKEKSNA----HSEFSHQNLNLNT 292
Query: 296 IGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEA 355
+ +F AG ETT++ +++ +L P V +++Y EI+Q +G R P + DR ++ EA
Sbjct: 293 LS-LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEA 351
Query: 356 TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE 415
I E+ R + PM +PH +S + + K TEV + L H+ + +PD F P+
Sbjct: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411
Query: 416 RFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468
FL+ G + + +++PF G R C+GE +AR ELFL +LQ F + P
Sbjct: 412 HFLDANGA--LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462
>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
[Homo sapiens]
Length = 490
Score = 180 bits (457), Expect = 2e-45
Identities = 138/488 (28%), Positives = 225/488 (46%), Gaps = 22/488 (4%)
Query: 4 LVALLLLTLAYLFWPKRRC-----PGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58
L+ LL L L L+ C P A++P LPLVG+L L R + +L +
Sbjct: 3 LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLL-RLSQQDRSLMELSE 61
Query: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118
+YGP+++V +G + TV++ + KE L G++ + RP +A + R G F SG
Sbjct: 62 RYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQ--RGGGIFFSSG 119
Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178
A W+ R+ + G + + I QE+ L L + G+ ++ + A +N+
Sbjct: 120 ARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGW-APSNI 178
Query: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSL--VDLVPWLKIFPNKTLEKLKSHV 236
+ F + DP + + ++ L L ++ PWL L+
Sbjct: 179 TFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIE 238
Query: 237 KIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTI 296
++R L + D + + +D L+Q G D + N + T+
Sbjct: 239 EVRAILRTLLEARRPHVCPGDPVCSYVDALIQQ-------GQGDDPEGLFAEANAVACTL 291
Query: 297 GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356
D+ AG ETT++ ++W + +P V+ ++ EE+D+ +G RTP + D+ L A
Sbjct: 292 -DMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAV 350
Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416
+ EV R + P +P D+ +G F + KGT VI L ++ +E +W P QF P
Sbjct: 351 LHEVQRFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGH 409
Query: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476
FL+ G + ++LPF AG R C+GE LAR ELFL+ A LLQR+ L P SL
Sbjct: 410 FLDANGHFV--KREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASL 467
Query: 477 EGIPKVVF 484
+ P F
Sbjct: 468 DTTPARAF 475
>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 2 [Homo sapiens]
Length = 431
Score = 174 bits (440), Expect = 2e-43
Identities = 132/465 (28%), Positives = 215/465 (46%), Gaps = 72/465 (15%)
Query: 5 VALLL-LTLAYLFWPKRRCPG-AKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGP 62
VAL+L L+ +L R+ G + P LP++G++ L M + K YGP
Sbjct: 5 VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKD-MSKSLTNFSKVYGP 63
Query: 63 IYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-GAHW 121
+++V G K V++ ++ KE LI G++FSGR + +A KG+ S G W
Sbjct: 64 VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGR---GSFPVAEKVNKGLGILFSNGKRW 120
Query: 122 QLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISL 181
+ RR + T F G + +E + +E L + L N D +F + A NVI
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
Query: 182 ICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRND 241
+ F+ R D
Sbjct: 181 VIFHD----------------------------------------------------RFD 188
Query: 242 LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301
++ N EKF ++++ + +Q K N Q SE ++ ++ T+ D+FG
Sbjct: 189 YKDQRFLNLMEKF-NENLRILSSPWIQEKHN---------QQSEFTVES-LIATVTDMFG 237
Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361
AG ETT++ +++ L LL P+V K+ EEI+ VG +R+P + DR+ + +A + E+
Sbjct: 238 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQ 297
Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421
R + P +PH D + + KGT +I +L ++ HN+KE+ P+ F P FL+ +
Sbjct: 298 RYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKS 357
Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
G S ++PF AG R C+GE LAR ELFL + +LQ F+L+
Sbjct: 358 GN--FKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK 400
>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
[Homo sapiens]
Length = 504
Score = 169 bits (427), Expect = 7e-42
Identities = 135/496 (27%), Positives = 239/496 (48%), Gaps = 17/496 (3%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63
L+AL LL L L R G P LPL+G+L L R G +++ +L KKYGP+
Sbjct: 10 LLALALLLLLTLALSGTRARG-HLPPGPTPLPLLGNLLQL-RPGALYSGLMRLSKKYGPV 67
Query: 64 YSVRMGT-KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQ 122
+++ +G + V++ + +E L + ++FSGR +A L+ + + G+ F++ G W+
Sbjct: 68 FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLE-GTFDGHGVFFSN-GERWR 125
Query: 123 LHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLI 182
R+ M G ++ E++I E L + G+ D S + A +NV+ +
Sbjct: 126 QLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSL 185
Query: 183 CFNTSYKNGDPELNVIQNYNEGIIDNLSKDS--LVDLVPW-LKIFPNKTLEKLKSHVKIR 239
F + D E + G + +S ++ W L+ P + L +
Sbjct: 186 LFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLA 245
Query: 240 NDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDI 299
+ ++ ++ S +++D + KM + N G +E + N ++T I +
Sbjct: 246 AFTVRQVQQHQGNLDASGPARDLVDAFL-LKMAQEEQNPG----TEFTNKNMLMTVIYLL 300
Query: 300 FGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIRE 359
F AG T ++ V +TL L+ P V+K + EE+++ +G + P++ DR RL +A + E
Sbjct: 301 F-AGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHE 359
Query: 360 VLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
RL + PM IP + + + +GTEV L ++ H+ + P++F P+RFL+
Sbjct: 360 AQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419
Query: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGI 479
G ++LPF G R C+GE LA+ ELFL +LQ F LE P SL+
Sbjct: 420 ADGR--FRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPT 477
Query: 480 PKVVFLI-DSFKVKIK 494
+F I +F+++++
Sbjct: 478 VSGLFNIPPAFQLQVR 493
>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 2 [Homo sapiens]
Length = 446
Score = 144 bits (364), Expect = 1e-34
Identities = 122/483 (25%), Positives = 213/483 (44%), Gaps = 72/483 (14%)
Query: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNN---FFKLQKKY 60
+VA+ LL + + +R+ A+YP L LP +G+L H N F +L++++
Sbjct: 12 IVAIFLLLVDLMH--RRQRWAARYPPGPLPLPGLGNL----LHVDFQNTPYCFDQLRRRF 65
Query: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIA--SNNRKGIAFADSG 118
G ++S+++ V++ +E L+ G+D + RP + I +G F +G
Sbjct: 66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNG 125
Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178
L+K + +NV
Sbjct: 126 L----------------------LDKAV-----------------------------SNV 134
Query: 179 ISLICFNTSYKNGDPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHV 236
I+ + ++ DP L ++ EG+ + +++ VP L P K+
Sbjct: 135 IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIP-ALAGKVLRFQ 193
Query: 237 KIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTI 296
K L+++L ++ + L A+M GN P+ +D ++ +
Sbjct: 194 KAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FNDENLCIVV 248
Query: 297 GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356
D+F AG+ TT++ + W L ++ +P V++++ +EID +G R P + D+ + A
Sbjct: 249 ADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAV 308
Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416
I EV R + P+ + H + D + F + KGT +I NL ++ +E W +P +F PE
Sbjct: 309 IHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH 368
Query: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476
FL+ G + P ++LPF AG R+C+GE LAR ELFL LLQ F VP PS
Sbjct: 369 FLDAQG-HFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH 426
Query: 477 EGI 479
G+
Sbjct: 427 HGV 429
>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 2 [Homo sapiens]
Length = 443
Score = 140 bits (353), Expect = 3e-33
Identities = 103/360 (28%), Positives = 184/360 (51%), Gaps = 13/360 (3%)
Query: 110 KGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISF 169
+G+AF++ QL R A+AT F G + +E+ I +E L + + + +G +ID +F
Sbjct: 63 QGVAFSNGERAKQL-LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTF 121
Query: 170 PVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPN 226
+ V+NVIS I F + D E + + GI + S L ++ +K P
Sbjct: 122 FLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPG 181
Query: 227 KTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286
+ K ++ D + K +E+ + +S + +D+ + M + N ++E
Sbjct: 182 PQQQAFKL-LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFL-IHMQEEEKNP----NTEF 235
Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346
N +++T+ ++F AG ET ++ +++ L+ +P+V+ K++EEID+ +G +R P D
Sbjct: 236 YLKNLMMSTL-NLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFED 294
Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406
R ++ +EA I E+ R V PM + + D+ +F + KGTEV L ++ + +
Sbjct: 295 RTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFF 354
Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
P F P+ FL+ G S +++PF G R+C GE LAR ELFL ++Q F L+
Sbjct: 355 SNPQDFNPQHFLDDKGQ--FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 412
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 122 bits (305), Expect = 1e-27
Identities = 125/458 (27%), Positives = 206/458 (44%), Gaps = 34/458 (7%)
Query: 32 LSLPLVGSLPFLPRHGHMHNNF----FKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 87
L +P LPFL H F + KKYG ++ G + + + + K VL+
Sbjct: 36 LGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV 95
Query: 88 KKGKD-FSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 146
K+ F+ R + + I+ A+ W+ R L TF KL++++
Sbjct: 96 KECYSVFTNRRPFGPVGFM---KSAISIAED-EEWKRLRSLLSPTFT-----SGKLKEMV 146
Query: 147 CQEISTLCDMLATHNGQSIDISFPVFVA-VTNVISL-ICFNTSYKNGDPELNVIQNYNEG 204
I+ D+L + + + PV + V S+ + +TS+ LN N +
Sbjct: 147 -PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN---NPQDP 202
Query: 205 IIDNLSK----DSLVDLVPWLKIFPN--KTLEKLKSHVKIRN--DLLNKILENYKEKFRS 256
++N K D L + +FP LE L V R + L K ++ KE
Sbjct: 203 FVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262
Query: 257 DSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLA 316
D+ + +D L ++ D+ N+ + + LSD ++ AG ETT+SV+ + +
Sbjct: 263 DTQKHRVDFL---QLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMY 319
Query: 317 FLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKAN 376
L +P V++KL EEID + PT ++ L+ + E LRL P+A M +
Sbjct: 320 ELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCK 378
Query: 377 VDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFG 436
D I + KG V+I +ALH + K W +P++F+PERF + I P + Y PFG
Sbjct: 379 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-SKKNKDNIDPYI-YTPFG 436
Query: 437 AGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474
+GPR+CIG A + L + +LQ F + + Q+P
Sbjct: 437 SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 119 bits (299), Expect = 5e-27
Identities = 129/488 (26%), Positives = 214/488 (43%), Gaps = 40/488 (8%)
Query: 2 WELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQ---- 57
W L+A+ L+ L YL+ + K L +P LPFL ++
Sbjct: 12 WLLLAVSLILL-YLYGTRTHGLFKK-----LGIPGPTPLPFLGNALSFRKGYWTFDMECY 65
Query: 58 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKD-FSGRPQMATLDIASNNRKGIAFAD 116
KKY ++ + + + + + K VL+K+ F+ R + N I+ A+
Sbjct: 66 KKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKN---AISIAE 122
Query: 117 SGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA--THNGQSIDISFPVFVA 174
W+ R L TF K +++ II Q L L G+ + +
Sbjct: 123 D-EEWKRIRSLLSPTFTSGKL--KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAY 179
Query: 175 VTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK----DSLVDLVPWLKIFPNKT-- 228
+VI+ F S ++ + N + ++N K + L V +K+FP T
Sbjct: 180 SMDVITSTSFGVS-------IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPI 232
Query: 229 LEKLKSHVKIRN--DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286
LE L V R L K ++ KE ++ + +D L ++ D+ N+ + +
Sbjct: 233 LEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFL---QLMIDSQNSKDSETHKA 289
Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346
LSD ++ AG ETT+SV+ + + L +P V++K+ +EID + PT
Sbjct: 290 LSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDT 349
Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406
+L L+ + E LRL PVA M + D I + KG V+I + LHH+ K W
Sbjct: 350 VLQLEYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYW 408
Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466
+P++F+PERF + I P + Y PFG+GPR+CIG A + L + +LQ F +
Sbjct: 409 TEPEKFLPERF-SKKNKDNIDPYI-YTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466
Query: 467 VPDDGQLP 474
+ Q+P
Sbjct: 467 PCKETQIP 474
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 119 bits (298), Expect = 7e-27
Identities = 111/456 (24%), Positives = 205/456 (44%), Gaps = 46/456 (10%)
Query: 33 SLPLVGSLPFLPRHGHM---HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKK 89
S PL+GSL + G + H+ + KKYG I+ +++G+ +V +G L E L +
Sbjct: 63 SWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLL-EALYRT 121
Query: 90 GKDFSGRPQMATLDIASNNRK---GIAFADSGAHWQLHRRLAMATFALFKDG-----DQK 141
+ R ++ + RK G+ + G WQ R L K G D K
Sbjct: 122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILE-GEDWQRVRSAFQKK--LMKPGEVMKLDNK 178
Query: 142 LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNY 201
+ +++ + + D L G D+ + I L+ + +
Sbjct: 179 INEVLADFMGRI-DELCDERGHVEDLYSELNKWSFESICLVLYEKRF------------- 224
Query: 202 NEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITN 261
G++ + D V+ + +K + + + V++ L K+ +++ + D+I
Sbjct: 225 --GLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAW--DTIFK 280
Query: 262 MLDTLMQAKMNSDNGNAGPDQDSEL-----LSDNHILTTIGDIFGAGVETTTSVVKWTLA 316
+ + ++ + D ++ LS + + ++ A VETT + + W L
Sbjct: 281 SVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILY 340
Query: 317 FLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP--HK 374
L NPQV++KL +EI + ++ P D + L+A ++E +RL P P K
Sbjct: 341 NLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDK 400
Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434
A V +GE+A+ KGT +++N L +E + QF PER+L + I+P ++LP
Sbjct: 401 ATV---LGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE--KEKINP-FAHLP 454
Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470
FG G R CIG LA +L L + W+++++D++ D+
Sbjct: 455 FGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN 490
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 119 bits (297), Expect = 8e-27
Identities = 135/521 (25%), Positives = 218/521 (41%), Gaps = 78/521 (14%)
Query: 5 VALLLLTLAYLFW------PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58
VAL + LA L W + G ++PK P +G+L F R G + +L+K
Sbjct: 19 VALSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFF-RQGFWESQM-ELRK 73
Query: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118
YGP+ +G + +++ + K+VL++ +F+ R + L+ S + D
Sbjct: 74 LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR-MASGLEFKSVADSVLFLRDK- 131
Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH------NGQSIDISFPVF 172
W+ R M+ F+ +KL +++ IS CD+L H +G + DI
Sbjct: 132 -RWEEVRGALMSAFS-----PEKLNEMV-PLISQACDLLLAHLKRYAESGDAFDIQRCYC 184
Query: 173 VAVTNVISLICFNTSYKNG----DPELNVIQNYNEGIIDN------LSKDSLVDLVPWLK 222
T+V++ + F T + DP + + + E I LS S+ +VP +
Sbjct: 185 NYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSI--MVPLAR 242
Query: 223 IFPNKTLEKLKSHVKIRNDLLNKILENY--------KEKFRSDSITNMLDTLMQAK---- 270
I PNK ++L N NK++ N E+ R D + +LD A
Sbjct: 243 ILPNKNRDEL-------NGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGV 295
Query: 271 ---------MNSDNGNAGPDQDSELLSDNHILTTIGDIFG-------AGVETTTSVVKWT 314
+S P + + LT + +I G AG E T+ + +
Sbjct: 296 QDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLT-VDEIVGQAFIFLIAGYEIITNTLSFA 354
Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTI-SDRNRLLLLEATIREVLRLRPVAPMLIPH 373
L NP ++KL E+D P S L L+ I E LR+ P A
Sbjct: 355 TYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTRE 414
Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433
A +G+ + G + + + ALHH+ + W P+ F PERF A Q +YL
Sbjct: 415 AAQDCEVLGQ-RIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ--HRPFTYL 471
Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474
PFGAGPRSC+G L E+ L + +L +F + + Q+P
Sbjct: 472 PFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVP 512
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 119 bits (297), Expect = 8e-27
Identities = 135/521 (25%), Positives = 218/521 (41%), Gaps = 78/521 (14%)
Query: 5 VALLLLTLAYLFW------PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58
VAL + LA L W + G ++PK P +G+L F R G + +L+K
Sbjct: 19 VALSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFF-RQGFWESQM-ELRK 73
Query: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118
YGP+ +G + +++ + K+VL++ +F+ R + L+ S + D
Sbjct: 74 LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR-MASGLEFKSVADSVLFLRDK- 131
Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH------NGQSIDISFPVF 172
W+ R M+ F+ +KL +++ IS CD+L H +G + DI
Sbjct: 132 -RWEEVRGALMSAFS-----PEKLNEMV-PLISQACDLLLAHLKRYAESGDAFDIQRCYC 184
Query: 173 VAVTNVISLICFNTSYKNG----DPELNVIQNYNEGIIDN------LSKDSLVDLVPWLK 222
T+V++ + F T + DP + + + E I LS S+ +VP +
Sbjct: 185 NYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSI--MVPLAR 242
Query: 223 IFPNKTLEKLKSHVKIRNDLLNKILENY--------KEKFRSDSITNMLDTLMQAK---- 270
I PNK ++L N NK++ N E+ R D + +LD A
Sbjct: 243 ILPNKNRDEL-------NGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGV 295
Query: 271 ---------MNSDNGNAGPDQDSELLSDNHILTTIGDIFG-------AGVETTTSVVKWT 314
+S P + + LT + +I G AG E T+ + +
Sbjct: 296 QDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLT-VDEIVGQAFIFLIAGYEIITNTLSFA 354
Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTI-SDRNRLLLLEATIREVLRLRPVAPMLIPH 373
L NP ++KL E+D P S L L+ I E LR+ P A
Sbjct: 355 TYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTRE 414
Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433
A +G+ + G + + + ALHH+ + W P+ F PERF A Q +YL
Sbjct: 415 AAQDCEVLGQ-RIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ--HRPFTYL 471
Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474
PFGAGPRSC+G L E+ L + +L +F + + Q+P
Sbjct: 472 PFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVP 512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,056,802
Number of Sequences: 37866
Number of extensions: 847573
Number of successful extensions: 1978
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1736
Number of HSP's gapped (non-prelim): 100
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.