Search of human proteins with 4502837

Search of human proteins with 4502837

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo
sapiens]
         (498 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]    1013   0.0  
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   621   e-178
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   451   e-127
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   447   e-125
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    429   e-120
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   385   e-107
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   382   e-106
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   382   e-106
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   379   e-105
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   372   e-103
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   358   8e-99
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   356   2e-98
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   337   2e-92
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   318   5e-87
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   306   3e-83
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   289   4e-78
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   280   3e-75
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              247   2e-65
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   204   2e-52
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   204   2e-52
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   190   2e-48
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              185   7e-47
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   148   1e-35
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   147   2e-35
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   136   4e-32
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...    95   1e-19
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...    95   1e-19
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...    91   2e-18
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor...    87   4e-17
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr...    86   6e-17

>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score = 1013 bits (2620), Expect = 0.0
 Identities = 498/498 (100%), Positives = 498/498 (100%)

Query: 1   MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60
           MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL
Sbjct: 1   MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60

Query: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120
           SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN
Sbjct: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120

Query: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180
           ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE
Sbjct: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180

Query: 181 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 240
           IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI
Sbjct: 181 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 240

Query: 241 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 300
           IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM
Sbjct: 241 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 300

Query: 301 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 360
           FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF
Sbjct: 301 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 360

Query: 361 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 420
           PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF
Sbjct: 361 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 420

Query: 421 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP 480
           RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP
Sbjct: 421 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP 480

Query: 481 PLFQTHAASEGPYAAQRD 498
           PLFQTHAASEGPYAAQRD
Sbjct: 481 PLFQTHAASEGPYAAQRD 498


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  621 bits (1601), Expect = e-178
 Identities = 315/486 (64%), Positives = 374/486 (76%), Gaps = 10/486 (2%)

Query: 7   LVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLI 66
           L+ F L+ LC        + EE+L++ LL+ +RYN LIRPAT+ S+L++++L +SLAQLI
Sbjct: 11  LLGFGLLRLCS--GVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLI 68

Query: 67  SVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYE 126
           SV+EREQIMTTNVWL QEW DYRLTW    ++ +  +R+P+K IWLPD+VLYNNADG YE
Sbjct: 69  SVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYE 128

Query: 127 VSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLM 186
           VS Y+N +V  +GS+ WLPPAIYKSACKIEVK+FPFDQQNCT+KFRSWTYD TEID+VL 
Sbjct: 129 VSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLK 188

Query: 187 TPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLT 246
           +  AS+DDFTPSGEWDIVALPGRR  NP D +YVD+TYDFII+RKPLFYTINLIIPCVL 
Sbjct: 189 SEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLI 248

Query: 247 TLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLV 306
           T LAILVFYLPSDCGEKMTLCISVLLALT FLLLISKIVPPTSLDVPL+GKYLMFTMVLV
Sbjct: 249 TSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLV 308

Query: 307 TFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSC 366
           TFSIVTSVCVLNVHHRSP+THTMAPWVK  FL KLP  LFM++P    +  R     +  
Sbjct: 309 TFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR-LRLRRRQ 367

Query: 367 VTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFWLRSSGRFRQD 423
             +  A A     +    +   FVN AS    A    A   PVA P     RS       
Sbjct: 368 REREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG----RSGEPCGCG 423

Query: 424 VQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLF 483
           ++EA++GV FIA HM+++D+DQSV EDWKYVAMV+DRLFLW+F+FVCV GT+G+FL PLF
Sbjct: 424 LREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLF 483

Query: 484 QTHAAS 489
           Q +  +
Sbjct: 484 QNYTTT 489


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  451 bits (1160), Expect = e-127
 Identities = 231/457 (50%), Positives = 302/457 (66%), Gaps = 18/457 (3%)

Query: 40  YNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEG 99
           YN   RP  ++S ++ ++  LS+AQLI V+E+ Q+MTTNVWLKQEW+DY+L WN + +  
Sbjct: 70  YNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGN 129

Query: 100 VNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKY 159
           +  LR+P++ IW+PDIVLYNNADG + V+  T   + S G+V W+PPAIYKS+C I+V +
Sbjct: 130 ITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTF 189

Query: 160 FPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQD--- 216
           FPFDQQNC +KF SWTYD  +ID+  M  T  + D+  SGEW IV   G       D   
Sbjct: 190 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA 249

Query: 217 PSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTF 276
             Y DVTY F+I+R PLFYTINLIIPC+L + L +LVFYLPSDCGEK+TLCISVLL+LT 
Sbjct: 250 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 309

Query: 277 FLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRC 336
           FLLLI++I+P TSL +PLIG+YL+FTM+ VT SIV +V VLNVHHRSPSTHTM  WV+  
Sbjct: 310 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA 369

Query: 337 FLHKLPTFLFMKRPGP----------DSSPARAFPPSKSCVTKPEATATSTSPSNFYGNS 386
            L  +P +L M RP P            SP+  +  S     + E            G+ 
Sbjct: 370 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV 429

Query: 387 MYFVNPASAASKSPAGSTPVAIPRDFWLRSSGR--FRQDVQEALEGVSFIAQHMKNDDED 444
              V    +     +G++    P+   L   G       +Q+ALEGV +IA H++++D D
Sbjct: 430 APSVGTLCSHGHLHSGASG---PKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDAD 486

Query: 445 QSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPP 481
            SV EDWKYVAMV+DR+FLW+F+ VC LGT+GLFLPP
Sbjct: 487 SSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPP 523


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  447 bits (1150), Expect = e-125
 Identities = 229/489 (46%), Positives = 317/489 (64%), Gaps = 15/489 (3%)

Query: 5   PSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQ 64
           P L+L  L++L      R + AE +L + L     YN +IRP  + S  + I  ++S++Q
Sbjct: 15  PRLLLLLLLSLLPVA--RASEAEHRLFERLFED--YNEIIRPVANVSDPVIIHFEVSMSQ 70

Query: 65  LISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGT 124
           L+ V+E  QIM TN+WLKQ W DY+L WN S Y G   +R+PA++IW PDIVLYNNA G 
Sbjct: 71  LVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGD 130

Query: 125 YEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMV 184
           ++V   T  +++  G V W+PPAI+KS+CKI+V YFPFD QNCT+KF SW+YD  +ID+V
Sbjct: 131 FQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV 190

Query: 185 LMTPTASMDDFTPSGEWDIVALPGRR---TVNPQDPSYVDVTYDFIIKRKPLFYTINLII 241
           L+  + ++ D+  SGEW I+  PG +     N  +  Y D+TY   I+R PLFYTINLII
Sbjct: 191 LIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLII 250

Query: 242 PCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMF 301
           PC+L + L +LVFYLPSDCGEK+TLCISVLL+LT FLL+I++ +P TSL +PLIG+YL+F
Sbjct: 251 PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLF 310

Query: 302 TMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFP 361
           TM+ VT SIV +V VLNVH+R+P+THTM  WVK  FL+ LP  +FM RP  +   A+   
Sbjct: 311 TMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR 370

Query: 362 P-------SKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDF-W 413
           P       + +C ++ E+           G   Y  +     S   A  T  +       
Sbjct: 371 PLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA 430

Query: 414 LRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLG 473
           + S      +++EA++ V +IA++MK  +E + + +DWKYVAMV+DR+FLWVF  VC+LG
Sbjct: 431 VLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILG 490

Query: 474 TVGLFLPPL 482
           T GLFL PL
Sbjct: 491 TAGLFLQPL 499


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  429 bits (1102), Expect = e-120
 Identities = 209/467 (44%), Positives = 300/467 (64%), Gaps = 12/467 (2%)

Query: 21  CRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVW 80
           C     EE+L   L +   YN  IRP  + S  +++  ++++ QL +V+E  QIM TN+W
Sbjct: 28  CVGCATEERLFHKLFS--HYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLW 85

Query: 81  LKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGS 140
           L+  W DY+L W+   Y+G+  LR+PA +IW PDIVLYNNA G ++V   T  +++ NG 
Sbjct: 86  LRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGM 145

Query: 141 VLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGE 200
           + W PPAI+KS+C +++ +FPFD QNC+LKF SWTYD  EID++++     M+DF  + E
Sbjct: 146 ITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSE 205

Query: 201 WDIVALPGRR---TVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLP 257
           W+I+   G +     N  +  Y D+TY F I+R P+FYTINLIIPC+  + L +LVFYLP
Sbjct: 206 WEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLP 265

Query: 258 SDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVL 317
           SDCGEK+TLCISVLL+LT FLL+I++ +P TSL VPL+G+YL+FTM+ VT SIV +V VL
Sbjct: 266 SDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVL 325

Query: 318 NVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATST 377
           N+H+R+P+THTM  WVK  FL  LP  L M+ P   +    +    +    +P     ++
Sbjct: 326 NIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLAS 385

Query: 378 SPSNFYGNSMYFVNPAS--AASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIA 435
                +    +  + ++  A SK      P+      W+  +     +V++ +  V FIA
Sbjct: 386 HGEPRHLKECFHCHKSNELATSKRRLSHQPLQ-----WVVENSEHSPEVEDVINSVQFIA 440

Query: 436 QHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPL 482
           ++MK+ +E + V +DWKYVAMVVDR+FLWVF+ VCV GT GLFL PL
Sbjct: 441 ENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPL 487


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  385 bits (989), Expect = e-107
 Identities = 197/465 (42%), Positives = 288/465 (61%), Gaps = 57/465 (12%)

Query: 23  VANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLK 82
           +A  E+ L+ DL     Y   +RP    +  I IK  L+++QL+ V+E+ Q+MTTNVWLK
Sbjct: 43  IAKHEDSLLKDLFQD--YERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLK 100

Query: 83  QEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVL 142
           QEW D +L WN   Y G+ ++R+P+  +W PDIVL++NADG +E    T  ++R NG+V 
Sbjct: 101 QEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVT 159

Query: 143 WLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWD 202
           W PPA YKS+C I+V +FPFD QNC++KF SWTYD +++D++L        DF  +GEW+
Sbjct: 160 WTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWE 219

Query: 203 IVALPGRRTVNPQDPS--YVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDC 260
           IV+  G +  N  D    Y  VTY F+IKR PLFYT+ LIIPC+  + L +LVFYLPS+ 
Sbjct: 220 IVSATGSKG-NRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNE 278

Query: 261 GEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVH 320
           GEK+ LC SVL++LT FLL+I +I+P +S  +PLIG+YL+FTM+ VT SI+ +V  +N+H
Sbjct: 279 GEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIH 338

Query: 321 HRSPSTH-TMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSP 379
           HRS STH  MAP V++ FLH LP  L M+     S   R F       T+ E T + + P
Sbjct: 339 HRSSSTHNAMAPLVRKIFLHTLPKLLCMR-----SHVDRYF-------TQKEETESGSGP 386

Query: 380 SNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMK 439
            +                                       R  ++ AL+ + +I +H+ 
Sbjct: 387 KS--------------------------------------SRNTLEAALDSIRYITRHIM 408

Query: 440 NDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQ 484
            +++ + VVEDWK++A V+DR+FLW F+FV ++G++GLF+P +++
Sbjct: 409 KENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYK 453


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  382 bits (982), Expect = e-106
 Identities = 200/464 (43%), Positives = 286/464 (61%), Gaps = 42/464 (9%)

Query: 23  VANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLK 82
           +A  E+ L+  L     Y   +RP   S+  I +   L ++QL+ V+E+ Q+MTTNVWLK
Sbjct: 25  IAENEDALLRHLFQG--YQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLK 82

Query: 83  QEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVL 142
           QEWTD++L WN   Y G++ +++P++ +WLPDIVL+ NADG +E S+ T +IV+SNG+V+
Sbjct: 83  QEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVV 142

Query: 143 WLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWD 202
           W PPA YKS+C ++V +FPFD+QNC++KF SWTYD T +D++L+       DF  +GEW+
Sbjct: 143 WTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWE 202

Query: 203 IVALPGRRTVNPQDP--SYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDC 260
           I+   G +  N +D   SY  +TY F+++R PLFYT+ LIIPC+  + L +LVFYLPSD 
Sbjct: 203 ILNAKGMKG-NRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 261

Query: 261 GEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVH 320
           GEK++L  SVL++LT FLL+I +I+P +S  +PLIG+YL+F M+ VT SI+ +V V+NVH
Sbjct: 262 GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVH 321

Query: 321 HRSPST-HTMAPWVKRCFLHKLPTFLFMK-RPGPDSSPARAFPPSKSCVTKPEATATSTS 378
           HRS ST H MAPWVKR FL KLP  L MK      SSP +        V K +       
Sbjct: 322 HRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEK---EESQPVVKGKVLEKKKQ 378

Query: 379 PSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHM 438
                G  +       AA                                + + +I++H+
Sbjct: 379 KQLSDGEKVLVAFLEKAA--------------------------------DSIRYISRHV 406

Query: 439 KNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPL 482
           K +     VV+DWK+VA V+DR+FLW+F+ V V G+V +F P L
Sbjct: 407 KKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL 450


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  382 bits (980), Expect = e-106
 Identities = 193/349 (55%), Positives = 244/349 (69%), Gaps = 12/349 (3%)

Query: 12  LVALCGRGNCRV-------ANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQ 64
           L+ L G G  R        A+AEE+L+  L +   YN   RP  + S ++ ++  LS+AQ
Sbjct: 15  LLLLLGTGLLRASSHVETRAHAEERLLKKLFSG--YNKWSRPVANISDVVLVRFGLSIAQ 72

Query: 65  LISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGT 124
           LI V+E+ Q+MTTNVW+KQEW DY+L W+ + YE V  +RIP++ IW PDIVLYNNADG 
Sbjct: 73  LIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGD 132

Query: 125 YEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMV 184
           + V+  T   +  +G V W PPAIYKS+C I+V +FPFDQQNCT+KF SWTYD  +ID+V
Sbjct: 133 FAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLV 192

Query: 185 LMTPTASMDDFTPSGEWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLII 241
            M       DF  SGEW IV   G       +     Y D+TY F+I+R PLFYTINLII
Sbjct: 193 NMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLII 252

Query: 242 PCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMF 301
           PC+L + L +LVFYLPS+CGEK+TLCISVLL+LT FLLLI++I+P TSL +PLIG+YL+F
Sbjct: 253 PCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLF 312

Query: 302 TMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRP 350
           TM+ VT SIV +V VLNVHHRSP THTM  WV+R FL  +P  L MKRP
Sbjct: 313 TMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRP 361



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 39/55 (70%), Positives = 48/55 (87%)

Query: 427 ALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPP 481
           A+EGV +IA H+K +D D SV EDWKYVAMV+DR+FLW+F+ VC+LGTVGLFLPP
Sbjct: 567 AVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPP 621


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  379 bits (972), Expect = e-105
 Identities = 205/482 (42%), Positives = 295/482 (61%), Gaps = 39/482 (8%)

Query: 22  RVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWL 81
           R + AE +L + L +   Y++ +RPA      + + + L LAQLIS+NE+++ M+T V+L
Sbjct: 22  RGSEAEGRLREKLFSG--YDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYL 79

Query: 82  KQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSV 141
             EWTDYRL+W+ + ++G++ LRI A+ +WLPD+VL NN DG ++V++  +++V S+GSV
Sbjct: 80  DLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSV 139

Query: 142 LWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVL-MTPTASMDD------ 194
            W PP IY+S+C I+V YFPFD QNCT+ F S++YD +E+ +   + P            
Sbjct: 140 RWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHE 199

Query: 195 --FTPSGEWDIVALPGRRTVNPQDP------SYVDVTYDFIIKRKPLFYTINLIIPCVLT 246
             F  +G+W+I+  P R    P DP         +V +  II+RKPLFY +N+I PC+L 
Sbjct: 200 GTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILI 259

Query: 247 TLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLV 306
           TLLAI VFYLP D GEKM L I  LL LT FLLL++  VP TSL VP+I KYLMFTMVLV
Sbjct: 260 TLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLV 319

Query: 307 TFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSC 366
           TFS++ SV VLN+HHRSP TH M  WV++ F+HKLP +L +KRP P+       P    C
Sbjct: 320 TFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERD---LMPEPPHC 376

Query: 367 VTKPEATATSTSPSNFYGNSM--YFVN--PASAASKSPAGSTPVAIPRDFWLRSSGRFR- 421
                     +SP + +G     YF+   P+      P    P     D      G  R 
Sbjct: 377 ----------SSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRA 426

Query: 422 ----QDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGL 477
                +++E +  +S+IA+ ++  ++  ++ EDW++VAMVVDRLFLW F+    +GT+ +
Sbjct: 427 VALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486

Query: 478 FL 479
           FL
Sbjct: 487 FL 488


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  372 bits (954), Expect = e-103
 Identities = 196/483 (40%), Positives = 287/483 (59%), Gaps = 43/483 (8%)

Query: 9   LFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISV 68
           L  L +LC  G    +  E +L+  L     Y++++RP     Q++ + + L L QLI+V
Sbjct: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQLIQLINV 63

Query: 69  NEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVS 128
           +E  QI+TTNV LKQ+W DY L WN   Y GV  + IP+++IW PD+VLYNNADG + + 
Sbjct: 64  DEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIV 123

Query: 129 VYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTP 188
            +T ++++  G + W PPAI+KS C+I V +FPFD+QNC++K  +WTYD + + +   + 
Sbjct: 124 KFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESD 183

Query: 189 TASMDDFTPSGEWDIVALPG-RRTVNPQ---DPSYVDVTYDFIIKRKPLFYTINLIIPCV 244
              + +F  SGEW I    G + +V      D  Y+D+TY F+++R PL++ +N+IIPC+
Sbjct: 184 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL 243

Query: 245 LTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMV 304
           L + L  LVFYLP+D GEKMTL ISVLL+LT FLL+I +++P TS  VPLIGKY++FTMV
Sbjct: 244 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV 303

Query: 305 LVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLF---MKRPGPDSSPARAFP 361
            V  SI+ +V V+N HHRSPSTH M  WV++ F+  +P  +F   MKRP  +    + F 
Sbjct: 304 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIF- 362

Query: 362 PSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFR 421
                    + +  S  P            P      SP    P                
Sbjct: 363 -----TEDIDISDISGKP-----------GPPPMGFHSPLIKHP---------------- 390

Query: 422 QDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPP 481
            +V+ A+EG+ +IA+ MK+D E  +   +WKYVAMV+D + L VFM VC++GT+ +F   
Sbjct: 391 -EVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGR 449

Query: 482 LFQ 484
           L +
Sbjct: 450 LIE 452


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  358 bits (918), Expect = 8e-99
 Identities = 196/508 (38%), Positives = 287/508 (56%), Gaps = 68/508 (13%)

Query: 9   LFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISV 68
           L  L +LC  G    +  E +L+  L     Y++++RP     Q++ + + L L QLI+V
Sbjct: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQLIQLINV 63

Query: 69  NEREQIMTTNVWLKQ-------------------------EWTDYRLTWNSSRYEGVNIL 103
           +E  QI+TTNV LKQ                         +W DY L WN   Y GV  +
Sbjct: 64  DEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKI 123

Query: 104 RIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFD 163
            IP+++IW PD+VLYNNADG + +  +T ++++  G + W PPAI+KS C+I V +FPFD
Sbjct: 124 HIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFD 183

Query: 164 QQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPG-RRTVNPQ---DPSY 219
           +QNC++K  +WTYD + + +   +    + +F  SGEW I    G + +V      D  Y
Sbjct: 184 EQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPY 243

Query: 220 VDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLL 279
           +D+TY F+++R PL++ +N+IIPC+L + L  LVFYLP+D GEKMTL ISVLL+LT FLL
Sbjct: 244 LDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLL 303

Query: 280 LISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLH 339
           +I +++P TS  VPLIGKY++FTMV V  SI+ +V V+N HHRSPSTH M  WV++ F+ 
Sbjct: 304 VIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFID 363

Query: 340 KLPTFLF---MKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAA 396
            +P  +F   MKRP  +    + F          + +  S  P            P    
Sbjct: 364 TIPNIMFFSTMKRPSREKQDKKIF------TEDIDISDISGKP-----------GPPPMG 406

Query: 397 SKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAM 456
             SP    P                 +V+ A+EG+ +IA+ MK+D E  +   +WKYVAM
Sbjct: 407 FHSPLIKHP-----------------EVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAM 449

Query: 457 VVDRLFLWVFMFVCVLGTVGLFLPPLFQ 484
           V+D + L VFM VC++GT+ +F   L +
Sbjct: 450 VMDHILLGVFMLVCIIGTLAVFAGRLIE 477


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  356 bits (914), Expect = 2e-98
 Identities = 202/502 (40%), Positives = 287/502 (57%), Gaps = 34/502 (6%)

Query: 5   PSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQ 64
           P L L  L AL   G+  + N EE+L+  L  +  YN  +RP     + + + L L+L+ 
Sbjct: 4   PVLTLGLLAALAVCGSWGL-NEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSN 62

Query: 65  LISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGT 124
           LIS+ E E+ +TTNVW++  WTD RL WN+  +  +++LR+P   +WLP+IVL NN DG+
Sbjct: 63  LISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGS 122

Query: 125 YEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMV 184
           +++S   N++V   G V WLPPAI++S+C I V YFPFD QNC+LKF S  Y   EI + 
Sbjct: 123 FQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLS 182

Query: 185 LMTPT------------ASMDDFTPSGEWDIVALPGRRTVNPQ----DPSYVDVTYDFII 228
           L                   + FT +GEW+IV  P R  V+P+     PS  D+T+  II
Sbjct: 183 LKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLII 242

Query: 229 KRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPT 288
           +RKPLFY IN+++PCVL + +  LVFYLP+D GEK ++ ISVLLA + FLLLISK +P T
Sbjct: 243 RRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPAT 302

Query: 289 SLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMK 348
           S+ +PLIGK+L+F MVLVT  +V  V VLN+H R+PSTH ++  VK+ FL  LP  L M 
Sbjct: 303 SMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMS 362

Query: 349 RPGPDS-SPARAFPPSKSC--VTKPEATATSTSPSNFYGNSMY----FVNPASAASKSPA 401
           RP  D  SP      S S   ++K E      S S+                + A + PA
Sbjct: 363 RPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPA 422

Query: 402 GSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRL 461
            S           ++      +++ A++G +FI  HM++ +      + W  VA  VDRL
Sbjct: 423 SSE----------QAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRL 472

Query: 462 FLWVFMFVCVLGTVGLFLPPLF 483
            L+V   V V+GT  +FL  ++
Sbjct: 473 CLFVVTPVMVVGTAWIFLQGVY 494


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  337 bits (863), Expect = 2e-92
 Identities = 182/471 (38%), Positives = 277/471 (58%), Gaps = 26/471 (5%)

Query: 27  EEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWT 86
           + KL  +L+    YN L RP  + SQ +++   LSL Q++ V+E+ Q++TTN+WL+  WT
Sbjct: 26  QRKLYKELVKN--YNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWT 83

Query: 87  DYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPP 146
           D+ L WN S Y GV  +R P  +IW PDI+LYN+AD  ++ + +TN++V S+G   +LPP
Sbjct: 84  DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP 143

Query: 147 AIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVAL 206
            I+KS+C I+V++FPFD Q+C LKF SW+Y    +D+ +    A +  + P+GEWD+V +
Sbjct: 144 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE--ADISGYIPNGEWDLVGI 201

Query: 207 PGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEK 263
           PG+R+    +     Y DVT+   ++R+ L+Y +NL+IPCVL + LA+LVF LP+D GEK
Sbjct: 202 PGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEK 261

Query: 264 MTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRS 323
           ++L I+VLL+LT F+LL+++I+P TS  VPLI +Y   TM++V  S+V +V VL  HH  
Sbjct: 262 ISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHD 321

Query: 324 PSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS-SPARAFPPSKSCVTKPEATATSTSPSNF 382
           P    M  W +   L+    FL MKRPG D   PA      +  +   E +A +  P++ 
Sbjct: 322 PDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPAS- 380

Query: 383 YGNSMYF-----------VNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQ---DVQEAL 428
            GN +Y              P S         +P     D  L   G+  +   D+ + L
Sbjct: 381 NGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT---HDEHLLHGGQPPEGDPDLAKIL 437

Query: 429 EGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL 479
           E V +IA   +  DE ++V  +WK+ A VVDRL L  F    ++ T+G+ +
Sbjct: 438 EEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  318 bits (816), Expect = 5e-87
 Identities = 189/492 (38%), Positives = 275/492 (55%), Gaps = 25/492 (5%)

Query: 7   LVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLI 66
           L+L  L+A+C     R  N EE+L+ DL+    Y+  +RPA   S ++++ L+L+L  LI
Sbjct: 8   LLLLLLLAVCLGAQGR--NQEERLLADLMQN--YDPNLRPAERDSDVVNVSLKLTLTNLI 63

Query: 67  SVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYE 126
           S+NERE+ +TTNVW++ +W DYRL W+   YEG+ +LR+P+  +W PDIVL NN DG +E
Sbjct: 64  SLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFE 123

Query: 127 VSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLM 186
           V++Y N++V  +G + WLPPAI++SAC I V YFPFD QNC+L F+S TY   EID+ L 
Sbjct: 124 VALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLS 183

Query: 187 TPTASM--------DDFTPSGEWDIVALPGRRTVNP----QDPSYVDVTYDFIIKRKPLF 234
                         + FT +GEW I   P +  ++P    Q+  +  V +  +I+RKPLF
Sbjct: 184 QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLF 243

Query: 235 YTINLIIPCVLTTLLAILVFYLPSDC-GEKMTLCISVLLALTFFLLLISKIVPPTSLDVP 293
           Y IN+I PCVL + +AIL+ +LP+   G+K T+ I+VLLA T FL L++K VP TS  VP
Sbjct: 244 YVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVP 303

Query: 294 LIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMK-RP-- 350
           LI KYL F +V+    +V +V VLNV  RSP TH+MA  V++ FL  LP  L M  RP  
Sbjct: 304 LISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLA 363

Query: 351 ---GPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVA 407
                D+        S   +T  E  A     S             +AA +       + 
Sbjct: 364 PAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGPELG 423

Query: 408 IPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFM 467
           + +  +  S  +    +Q  +E  + IA          +  E+W  V  V+DR+     +
Sbjct: 424 LSQ--FCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAML 481

Query: 468 FVCVLGTVGLFL 479
            + + GT G+FL
Sbjct: 482 SLFICGTAGIFL 493


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  306 bits (784), Expect = 3e-83
 Identities = 185/512 (36%), Positives = 278/512 (54%), Gaps = 42/512 (8%)

Query: 1   MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60
           M RAP  VL  L+ L GRG  +  N E +L   L N   Y+   RP       ++I L++
Sbjct: 1   MARAPLGVLL-LLGLLGRGVGK--NEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKV 55

Query: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120
           +L  LIS+NE+E+ +TT+VW+  +W DYRL ++   + G+  LR+P++ +WLP+IVL NN
Sbjct: 56  TLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENN 115

Query: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180
            DG + V+   N++V   GSV WLPPAIY+S C +EV YFPFD QNC+L FRS TY+  E
Sbjct: 116 IDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEE 175

Query: 181 IDMVLMTPT---------ASMDDFTPSGEWDIVALPG---RRTVNPQD-PSYVDVTYDFI 227
           ++                   + +T +GEW I   PG   R      D P   DV Y  I
Sbjct: 176 VEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLI 235

Query: 228 IKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCG-EKMTLCISVLLALTFFLLLISKIVP 286
           I+RKPLFY IN+I+PCVL + L +L ++LP+  G +K T+ I+VLLA T FL LI++ +P
Sbjct: 236 IRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIP 295

Query: 287 PTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLF 346
            TSL VPL+G++L+F MV+ T  ++  V VLNV  R+P+TH M+P ++   L  LP  L 
Sbjct: 296 ETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL- 354

Query: 347 MKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA----ASKSPAG 402
              P P  +P  A PP ++          S+         +    P S       +   G
Sbjct: 355 -GSPPPPEAPRAASPPRRA----------SSVGLLLRAEELILKKPRSELVFEGQRHRQG 403

Query: 403 STPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLF 462
           +   A     + +S G    +V+  ++ V+F+A+  ++ +     V DW  +   +D + 
Sbjct: 404 TWTAA-----FCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNIC 458

Query: 463 LWVFMFVCVLGTVGLFLPPLFQTHAASEGPYA 494
            W  + +  +G+  +FL   F  +   + PYA
Sbjct: 459 FWAALVLFSVGSSLIFLGAYF--NRVPDLPYA 488


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  289 bits (740), Expect = 4e-78
 Identities = 170/469 (36%), Positives = 259/469 (55%), Gaps = 44/469 (9%)

Query: 7   LVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLI 66
           L+LF L A C     R+A    KL  DL     Y + +RP   + Q +++ L+++L+Q+I
Sbjct: 13  LLLFLLPAECLGAEGRLAL---KLFRDLF--ANYTSALRPVADTDQTLNVTLEVTLSQII 67

Query: 67  SVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYE 126
            ++ER Q++T  +W++QEWTD  L W+ + Y G++ +RIP+  +W PDIVLYN AD    
Sbjct: 68  DMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPP 127

Query: 127 VSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLM 186
            S  TN+++R +G+V W  PAI +S+C+++V  FPFD Q+C L F SWT+   ++D+   
Sbjct: 128 GSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPR 187

Query: 187 TPTASMDDFTPSGEWDIVALPGRRTVNPQ---DPSYVDVTYDFIIKRKPLFYTINLIIPC 243
              AS+ DF  + EW ++ +P RR V         Y DVT+  +++R+   Y  NL++PC
Sbjct: 188 GAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPC 247

Query: 244 VLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTM 303
           VL +LLA L F+LP+D GEK++L ++VLLALT F LL+++ +PP    VPLIGKY M TM
Sbjct: 248 VLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMATM 306

Query: 304 VLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPS 363
            +VTFS   ++ ++N+H+  PS   +  W +   L  L   L ++  G     +R     
Sbjct: 307 TMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRP---- 362

Query: 364 KSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQD 423
                 PE + +  SP    G               PAG  P   PR          RQ+
Sbjct: 363 ------PELSPSPQSPEGGAG--------------PPAG--PCHEPRCLC-------RQE 393

Query: 424 VQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVL 472
               L  V+ IA   ++    Q   EDWK +A V+DR FL +F  + ++
Sbjct: 394 A--LLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALV 440


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  280 bits (715), Expect = 3e-75
 Identities = 152/459 (33%), Positives = 252/459 (54%), Gaps = 29/459 (6%)

Query: 28  EKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTD 87
           +KL +DL     Y+N +RP   + +++++ LQ++L+Q+  ++ER QI+T  +W++Q W D
Sbjct: 32  QKLFNDLFED--YSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHD 89

Query: 88  YRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPA 147
             LTW+  +Y+G++ +RIP+  +W PDIVLYN AD      V TN+++R +G + W  PA
Sbjct: 90  AYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPA 149

Query: 148 IYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALP 207
           I KS+C ++V YFPFD Q C L F SWTY+  ++D+     +  + DF    EW++  +P
Sbjct: 150 ITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMP 209

Query: 208 GRRTVNPQ---DPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKM 264
             + V         Y DVT+  ++KR+  FY +NL+IPCVL + LA L FYLP+  GEK+
Sbjct: 210 AVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKV 269

Query: 265 TLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSP 324
           +L +++LLA+T F L++++I+ P S +VPLIGKY + TM L+T S   ++ V+N+H    
Sbjct: 270 SLGVTILLAMTVFQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIHFCGA 328

Query: 325 STHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTK-----PEA---TATS 376
               +  W +   L  +   LF+   G +S  +      +  +TK     PE+    A +
Sbjct: 329 EARPVPHWARVVILKYMSRVLFVYDVG-ESCLSPHHSRERDHLTKVYSKLPESNLKAARN 387

Query: 377 TSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQ 436
              S     +    N      K+P              + +  +    +     + +IA+
Sbjct: 388 KDLSRKKDMNKRLKNDLGCQGKNP--------------QEAESYCAQYKVLTRNIEYIAK 433

Query: 437 HMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTV 475
            +K+     S   +WK VA V+DR F+W+F  +  + T+
Sbjct: 434 CLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  247 bits (631), Expect = 2e-65
 Identities = 140/377 (37%), Positives = 215/377 (57%), Gaps = 24/377 (6%)

Query: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180
           AD  ++ + +TN++V S+G   +LPP I+KS+C I+V++FPFD Q+C LKF SW+Y    
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87

Query: 181 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTI 237
           +D+ +    A +  + P+GEWD+V +PG+R+    +     Y DVT+   ++R+ L+Y +
Sbjct: 88  LDLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145

Query: 238 NLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGK 297
           NL+IPCVL + LA+LVF LP+D GEK++L I+VLL+LT F+LL+++I+P TS  VPLI +
Sbjct: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205

Query: 298 YLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS-SP 356
           Y   TM++V  S+V +V VL  HH  P    M  W +   L+    FL MKRPG D   P
Sbjct: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 265

Query: 357 ARAFPPSKSCVTKPEATATSTSPSNFYGNSMYF-----------VNPASAASKSPAGSTP 405
           A      +  +   E +A +  P++  GN +Y              P S         +P
Sbjct: 266 ACQHKQRRCSLASVEMSAVAPPPAS-NGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSP 324

Query: 406 VAIPRDFWLRSSGRFRQ---DVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLF 462
                D  L   G+  +   D+ + LE V +IA   +  DE ++V  +WK+ A VVDRL 
Sbjct: 325 T---HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC 381

Query: 463 LWVFMFVCVLGTVGLFL 479
           L  F    ++ T+G+ +
Sbjct: 382 LMAFSVFTIICTIGILM 398


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  204 bits (519), Expect = 2e-52
 Identities = 130/486 (26%), Positives = 238/486 (48%), Gaps = 35/486 (7%)

Query: 6   SLVLFFLVALCGRGNCRVAN-----AEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60
           +L+   L  L  +G  R +      A  +L D LL  T Y   +RP     +  ++ + +
Sbjct: 14  ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLL--TNYRKGVRPVRDWRKPTTVSIDV 71

Query: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120
            +  +++V+E+ Q++TT +W +Q WTD  L WN   ++ +  L IP   IW+PDI++   
Sbjct: 72  IVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEF 131

Query: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180
            D     ++   + +R  G V    P    +AC +++  FPFD QNC+L F SW +   +
Sbjct: 132 VDVGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQD 190

Query: 181 IDMVLMT-PTASMDD---FTPSGEWDIVA-LPGRRTVNPQDPSY-VDVTYDFIIKRKPLF 234
           I++ L   P     D   F   GEW+++  LP  R  + +  +Y  ++ +  +I+R+PLF
Sbjct: 191 INISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLF 250

Query: 235 YTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPL 294
           Y ++L++P +   ++ I+ FYLP + GE+++  I++LL  + FL+++S  +P T++  PL
Sbjct: 251 YVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPL 310

Query: 295 IGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS 354
           IG Y +  M L+  S+  ++ ++ + H+      +  W++   L ++   L ++      
Sbjct: 311 IGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQ 370

Query: 355 SPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAG-STPVAIPRDFW 413
                 PP+ S        AT T   +  GN    +       KSP    +P   PR+  
Sbjct: 371 R-----PPATS-------QATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREAS 418

Query: 414 LRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLG 473
           L   G         L+ +S I Q ++  DE + V  DW  V  V+D+L   +++   +  
Sbjct: 419 LAVCG--------LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAY 470

Query: 474 TVGLFL 479
           ++ L +
Sbjct: 471 SITLVM 476


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  204 bits (518), Expect = 2e-52
 Identities = 130/476 (27%), Positives = 234/476 (49%), Gaps = 32/476 (6%)

Query: 11  FLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNE 70
           FL A   R   R A    +L D LL  T Y   +RP     +  ++ + + +  +++V+E
Sbjct: 5   FLQARRSRNTTRPALL--RLSDYLL--TNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDE 60

Query: 71  REQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVY 130
           + Q++TT +W +Q WTD  L WN   ++ +  L IP   IW+PDI++    D     ++ 
Sbjct: 61  KNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNI- 119

Query: 131 TNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMT-PT 189
             + +R  G V    P    +AC +++  FPFD QNC+L F SW +   +I++ L   P 
Sbjct: 120 PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPE 179

Query: 190 ASMDD---FTPSGEWDIVA-LPGRRTVNPQDPSY-VDVTYDFIIKRKPLFYTINLIIPCV 244
               D   F   GEW+++  LP  R  + +  +Y  ++ +  +I+R+PLFY ++L++P +
Sbjct: 180 KVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSI 239

Query: 245 LTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMV 304
              ++ I+ FYLP + GE+++  I++LL  + FL+++S  +P T++  PLIG Y +  M 
Sbjct: 240 FLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMA 299

Query: 305 LVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSK 364
           L+  S+  ++ ++ + H+      +  W++   L ++   L ++            PP+ 
Sbjct: 300 LLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQR-----PPAT 354

Query: 365 SCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAG-STPVAIPRDFWLRSSGRFRQD 423
           S        AT T   +  GN    +       KSP    +P   PR+  L   G     
Sbjct: 355 S-------QATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCG----- 402

Query: 424 VQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL 479
               L+ +S I Q ++  DE + V  DW  V  V+D+L   +++   +  ++ L +
Sbjct: 403 ---LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 455


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  190 bits (483), Expect = 2e-48
 Identities = 131/518 (25%), Positives = 239/518 (46%), Gaps = 67/518 (12%)

Query: 6   SLVLFFLVALCGRGNCRVAN-----AEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60
           +L+   L  L  +G  R +      A  +L D LL  T Y   +RP     +  ++ + +
Sbjct: 14  ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLL--TNYRKGVRPVRDWRKPTTVSIDV 71

Query: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120
            +  +++V+E+ Q++TT +W +Q WTD  L WN   ++ +  L IP   IW+PDI++   
Sbjct: 72  IVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEF 131

Query: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180
            D     ++   + +R  G V    P    +AC +++  FPFD QNC+L F SW +   +
Sbjct: 132 VDVGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQD 190

Query: 181 IDMVLMT-PTASMDD---FTPSGEWDIVA-LPGRRTVNPQDPSY-VDVTYDFIIKRKPLF 234
           I++ L   P     D   F   GEW+++  LP  R  + +  +Y  ++ +  +I+R+PLF
Sbjct: 191 INISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLF 250

Query: 235 YTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPL 294
           Y ++L++P +   ++ I+ FYLP + GE+++  I++LL  + FL+++S  +P T++  PL
Sbjct: 251 YVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPL 310

Query: 295 IGK--------------------------------YLMFTMVLVTFSIVTSVCVLNVHHR 322
           IGK                                Y +  M L+  S+  ++ ++ + H+
Sbjct: 311 IGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHK 370

Query: 323 SPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNF 382
                 +  W++   L ++   L ++       P     P+ S        AT T   + 
Sbjct: 371 QDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP-----PATS-------QATKTDDCSA 418

Query: 383 YGNSMYFVNPASAASKSPAGS-TPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKND 441
            GN    +       KSP    +P   PR+  L   G         L+ +S I Q ++  
Sbjct: 419 MGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCG--------LLQELSSIRQFLEKR 470

Query: 442 DEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL 479
           DE + V  DW  V  V+D+L   +++   +  ++ L +
Sbjct: 471 DEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  185 bits (470), Expect = 7e-47
 Identities = 111/308 (36%), Positives = 168/308 (54%), Gaps = 22/308 (7%)

Query: 190 ASMDDFTPSGEWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLT 246
           A +  + P+GEWD+V +PG+R+    +     Y DVT+   ++R+ L+Y +NL+IPCVL 
Sbjct: 4   ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 63

Query: 247 TLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLV 306
           + LA+LVF LP+D GEK++L I+VLL+LT F+LL+++I+P TS  VPLI +Y   TM++V
Sbjct: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123

Query: 307 TFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS-SPARAFPPSKS 365
             S+V +V VL  HH  P    M  W +   L+    FL MKRPG D   PA      + 
Sbjct: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183

Query: 366 CVTKPEATATSTSPSNFYGNSMYF-----------VNPASAASKSPAGSTPVAIPRDFWL 414
            +   E +A +  P++  GN +Y              P S         +P     D  L
Sbjct: 184 SLASVEMSAVAPPPAS-NGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT---HDEHL 239

Query: 415 RSSGRFRQ---DVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCV 471
              G+  +   D+ + LE V +IA   +  DE ++V  +WK+ A VVDRL L  F    +
Sbjct: 240 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI 299

Query: 472 LGTVGLFL 479
           + T+G+ +
Sbjct: 300 ICTIGILM 307


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  148 bits (374), Expect = 1e-35
 Identities = 81/291 (27%), Positives = 151/291 (51%), Gaps = 12/291 (4%)

Query: 39  RYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYE 98
           +Y+  +RP  + ++  ++ L L +  ++ V+   QI+ T+VW ++ W D  L+WNSS ++
Sbjct: 42  KYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFD 101

Query: 99  GVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNL---IVRSNGSVLWLPPAIYKSACKI 155
            +  + +P   IW PDI++    D    +  Y +L    V S+G++    P    SAC +
Sbjct: 102 EIREISLPLSAIWAPDIIINEFVD----IERYPDLPYVYVNSSGTIENYKPIQVVSACSL 157

Query: 156 EVKYFPFDQQNCTLKFRSWTYDHTEIDMV-LMTPTASMDD---FTPSGEWDIVALPGRRT 211
           E   FPFD QNC+L F+S  +   ++D+  L +P     D   F    EW+++++    +
Sbjct: 158 ETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYS 217

Query: 212 V-NPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISV 270
           +       +  + ++ +++R PL Y ++L+IP +   L+ +  FYLP +C  ++    SV
Sbjct: 218 ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSV 277

Query: 271 LLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHH 321
           L+  T F + +S  VP +    PLIG +    M  +  S+  S+ ++   H
Sbjct: 278 LVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  147 bits (372), Expect = 2e-35
 Identities = 89/312 (28%), Positives = 154/312 (49%), Gaps = 10/312 (3%)

Query: 35  LNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNS 94
           LN        RP T+ S    + +  +++ ++ VNE+  ++++ +WL+  W +  ++WN 
Sbjct: 60  LNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNP 119

Query: 95  SRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACK 154
              EG+  + + AK +WLPDI +    D        T   V + G + +  P    S C 
Sbjct: 120 EECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICN 178

Query: 155 IEVKYFPFDQQNCTLKFRSWTY--DHTEIDM---VLMTPTASMDDFTPSGEWDIVAL-PG 208
           +++ YFPFDQQNCTL F S+ Y  D   +DM   V     AS +     GEW+++ L   
Sbjct: 179 LDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKA 238

Query: 209 RRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCI 268
              ++     Y  + +   I+R+P  Y INL++P      +  L FYLP   G ++   I
Sbjct: 239 TAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKI 298

Query: 269 SVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHT 328
           ++LL    FLL++S ++P +    PLIG Y    + L+  S++ ++ + ++ H + +   
Sbjct: 299 TLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPP 356

Query: 329 MAP-WVKRCFLH 339
             P W+    LH
Sbjct: 357 PLPRWLHSLLLH 368


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  136 bits (343), Expect = 4e-32
 Identities = 90/352 (25%), Positives = 171/352 (48%), Gaps = 20/352 (5%)

Query: 2   RRAPSLVLFFLVALCGRGNCRVANA---EEKLMDDLLNKTRYNN-LIRPATSSSQLISIK 57
           R++  L L   + L GRG+    N    ++  +D  + +  ++    RP T+ S    + 
Sbjct: 8   RQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVN 67

Query: 58  LQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVL 117
           +  +L+ ++ V+ + Q++T+ +W+   W +  + WN     G+N L + A+ +WLPDI +
Sbjct: 68  ISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFI 127

Query: 118 YNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYD 177
             + D     S  T   + S G + +  P    S C +++ YFPFDQQNCT  F S+ Y 
Sbjct: 128 VESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLY- 185

Query: 178 HTEIDMVLMTPTASMDDFTPS--------GEWDIVAL-PGRRTVNPQDPSYVDVTYDFII 228
              +D +L+     + + T +        GEW+++ +      ++  +  Y  + +   I
Sbjct: 186 --TVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAI 243

Query: 229 KRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPT 288
           +R+P  Y INL++P      +  L FYLP++   +    I++LL    FLL+++ ++P +
Sbjct: 244 RRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPAS 303

Query: 289 SLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAP-WVKRCFLH 339
               PLI  Y    + L+  S++ +V +  + H + +     P W+    LH
Sbjct: 304 G--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLH 353


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 73/299 (24%), Positives = 137/299 (45%), Gaps = 24/299 (8%)

Query: 29  KLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDY 88
           +++D LL+   Y+N +RP    S +  +   + +     V++ +   T +V+ +Q+W D 
Sbjct: 44  RILDRLLDG--YDNRLRPGLGDS-ITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDE 100

Query: 89  RLTWNSSRYEGVNILRIP---AKRIWLPDIVLYNNADGTYEVSVYTNLIVR--SNGSVLW 143
           RL +       +NILR+    A +IW PD   +N            N ++R   +G++L+
Sbjct: 101 RLKFKGP----MNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLY 156

Query: 144 LPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSG---- 199
                 ++ C + ++ FP D  +C LKF S+ Y  +E+  +     +      P G    
Sbjct: 157 TMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLN 216

Query: 200 EWDIVALP-GRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPS 258
           ++D++    G+ T+      Y  +T  F +KRK  ++ I   +PC++T +L+ + F+L  
Sbjct: 217 QYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR 276

Query: 259 DCGEKMTLCISVLLALTFFLLLIS------KIVPPTSLDVPLIGKYLMFTMVLVTFSIV 311
           +     T+   V   LT   L IS      K+   T++D  +   Y      L+ F+ V
Sbjct: 277 ESVPARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV 334


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 73/299 (24%), Positives = 137/299 (45%), Gaps = 24/299 (8%)

Query: 29  KLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDY 88
           +++D LL+   Y+N +RP    S +  +   + +     V++ +   T +V+ +Q+W D 
Sbjct: 44  RILDRLLDG--YDNRLRPGLGDS-ITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDE 100

Query: 89  RLTWNSSRYEGVNILRIP---AKRIWLPDIVLYNNADGTYEVSVYTNLIVR--SNGSVLW 143
           RL +       +NILR+    A +IW PD   +N            N ++R   +G++L+
Sbjct: 101 RLKFKGP----MNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLY 156

Query: 144 LPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSG---- 199
                 ++ C + ++ FP D  +C LKF S+ Y  +E+  +     +      P G    
Sbjct: 157 TMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLN 216

Query: 200 EWDIVALP-GRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPS 258
           ++D++    G+ T+      Y  +T  F +KRK  ++ I   +PC++T +L+ + F+L  
Sbjct: 217 QYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR 276

Query: 259 DCGEKMTLCISVLLALTFFLLLIS------KIVPPTSLDVPLIGKYLMFTMVLVTFSIV 311
           +     T+   V   LT   L IS      K+   T++D  +   Y      L+ F+ V
Sbjct: 277 ESVPARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV 334


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 76/308 (24%), Positives = 135/308 (43%), Gaps = 31/308 (10%)

Query: 11  FLVALCGRG---NCRVANAEEKLMDDLLNKTR-YNNLIRPATSSSQLISIKLQLSLAQLI 66
           F   +C +G   N  V  +++  +    N T  YN  +RP     + + I L L +A + 
Sbjct: 15  FTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRP-NFGGEPVQIALTLDIASIS 73

Query: 67  SVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRI---WLPDIVLYNNADG 123
           S++E     T  ++L+Q W D RL      +EG     + A+ +   W+PD  +  +   
Sbjct: 74  SISESNMDYTATIYLRQRWMDQRLV-----FEGNKSFTLDARLVEFLWVPDTYIVESKKS 128

Query: 124 -TYEVSVYTNLI-VRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEI 181
             +EV+V   LI + SNG+VL+        AC +++  +P D Q C L+  SW YD  ++
Sbjct: 129 FLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDV 188

Query: 182 DMVLMTPTAS--------MDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPL 233
           +   +    S        +  +T    + +V    + T N     Y  +   F ++R  L
Sbjct: 189 EFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGN-----YTRLVLQFELRRNVL 243

Query: 234 FYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISK--IVPPTSLD 291
           ++ +   +P     +L+ + F++  D     T CI V   L+   L+I     +P T+  
Sbjct: 244 YFILETYVPSTFLVVLSWVSFWISLDSVPART-CIGVTTVLSMTTLMIGSRTSLPNTNCF 302

Query: 292 VPLIGKYL 299
           +  I  YL
Sbjct: 303 IKAIDVYL 310


>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
           [Homo sapiens]
          Length = 492

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 90/402 (22%), Positives = 168/402 (41%), Gaps = 41/402 (10%)

Query: 29  KLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDY 88
           +++D LL+   Y+N +RP    + +  +K  + +     V++ +   T +V+ +Q W D 
Sbjct: 69  RILDRLLDG--YDNRLRPGLGDA-VTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDE 125

Query: 89  RLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVR--SNGSVLWLPP 146
           RL ++    + + +  + A +IW PD   +N            N ++R   NG++L+   
Sbjct: 126 RLKFDGPM-KILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMR 184

Query: 147 AIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEI----DMVLMTPTASMDDFTPSGEWD 202
               + C + ++ FP D   C LKF S+ Y   E+     +          D +   ++D
Sbjct: 185 LTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYD 244

Query: 203 IVA-LPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCG 261
           ++  + G   +      YV +T  F +KRK  ++ I   +PC++T +L+ + F+L  +  
Sbjct: 245 LLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 304

Query: 262 EKMTLCISVLLALTFFLLLIS------KIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVC 315
              T+   V   LT   L IS      K+   T++D  +   Y      L+ F+ V    
Sbjct: 305 PARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV---- 359

Query: 316 VLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATAT 375
                    +  T   W       K+P  L MK+  P +       P+K   T      T
Sbjct: 360 ---------NYFTKRSWAWEG--KKVPEALEMKKKTPAA-------PAKKTSTTFNIVGT 401

Query: 376 STSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSS 417
            T P N   ++ +      AA  + +  T +A P+  +++ S
Sbjct: 402 -TYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDS 442


>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
           precursor [Homo sapiens]
          Length = 462

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 67/296 (22%), Positives = 134/296 (45%), Gaps = 18/296 (6%)

Query: 29  KLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDY 88
           +++D LL+   Y+N +RP     ++  ++  + +     V++ E   T +V+ +Q W D 
Sbjct: 51  RILDGLLDG--YDNRLRPGLGE-RITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDE 107

Query: 89  RLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVR--SNGSVLWLPP 146
           RL +     + + +  + A +IW PD   +N            N ++R   +G++L+   
Sbjct: 108 RLRFKGPM-QRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMR 166

Query: 147 AIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTAS----MDDFTPSGEWD 202
               + C ++++ FP D   C LKF S+ Y ++E+  V    +       +D +   ++ 
Sbjct: 167 LTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYH 226

Query: 203 IVA-LPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCG 261
           ++    G   ++     Y  +T  F +KRK  ++ I   +PC++T +L+ + F+L  +  
Sbjct: 227 LMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 286

Query: 262 EKMTLCISVLLALTFFLLLIS------KIVPPTSLDVPLIGKYLMFTMVLVTFSIV 311
              T+   V   LT   L IS      K+   T++D  +   Y      L+ F+ V
Sbjct: 287 PARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV 341


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.136    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,831,838
Number of Sequences: 37866
Number of extensions: 893652
Number of successful extensions: 3640
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3362
Number of HSP's gapped (non-prelim): 193
length of query: 498
length of database: 18,247,518
effective HSP length: 106
effective length of query: 392
effective length of database: 14,233,722
effective search space: 5579619024
effective search space used: 5579619024
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.