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Search of human proteins with 4502831
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor
[Homo sapiens]
(502 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H... 1045 0.0
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens] 803 0.0
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens] 661 0.0
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens] 358 8e-99
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ... 357 1e-98
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens] 337 2e-92
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens] 331 1e-90
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec... 329 4e-90
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec... 328 7e-90
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi... 328 7e-90
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [... 322 5e-88
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec... 314 1e-85
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre... 300 2e-81
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [... 287 1e-77
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens] 278 1e-74
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec... 270 2e-72
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr... 251 8e-67
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p... 234 1e-61
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ... 221 1e-57
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform... 208 8e-54
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform... 207 2e-53
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform... 193 3e-49
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor... 162 5e-40
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens] 150 2e-36
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens] 148 1e-35
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens] 78 2e-14
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 75 2e-13
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 75 2e-13
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s... 73 5e-13
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 72 9e-13
>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
sapiens]
Length = 502
Score = 1045 bits (2702), Expect = 0.0
Identities = 502/502 (100%), Positives = 502/502 (100%)
Query: 1 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL 60
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
Sbjct: 1 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL 60
Query: 61 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
Sbjct: 61 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120
Query: 121 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL 180
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
Sbjct: 121 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL 180
Query: 181 QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP 240
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
Sbjct: 181 QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP 240
Query: 241 CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST 300
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
Sbjct: 241 CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST 300
Query: 301 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK 360
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
Sbjct: 301 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK 360
Query: 361 QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL 420
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
Sbjct: 361 QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL 420
Query: 421 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI 480
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
Sbjct: 421 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI 480
Query: 481 ICTIGILMSAPNFVEAVSKDFA 502
ICTIGILMSAPNFVEAVSKDFA
Sbjct: 481 ICTIGILMSAPNFVEAVSKDFA 502
>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
Length = 412
Score = 803 bits (2074), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 118 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 177
ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS
Sbjct: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
Query: 178 LDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNL 237
LDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNL
Sbjct: 88 LDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNL 147
Query: 238 LIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYF 297
LIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYF
Sbjct: 148 LIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYF 207
Query: 298 ASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPAC 357
ASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPAC
Sbjct: 208 ASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPAC 267
Query: 358 QHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHD 417
QHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHD
Sbjct: 268 QHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHD 327
Query: 418 EHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSV 477
EHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSV
Sbjct: 328 EHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSV 387
Query: 478 FTIICTIGILMSAPNFVEAVSKDFA 502
FTIICTIGILMSAPNFVEAVSKDFA
Sbjct: 388 FTIICTIGILMSAPNFVEAVSKDFA 412
>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
Length = 321
Score = 661 bits (1705), Expect = 0.0
Identities = 321/321 (100%), Positives = 321/321 (100%)
Query: 182 MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 241
MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC
Sbjct: 1 MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60
Query: 242 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 301
VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM
Sbjct: 61 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120
Query: 302 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 361
IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ
Sbjct: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180
Query: 362 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 421
RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL
Sbjct: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 240
Query: 422 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 481
HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII
Sbjct: 241 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300
Query: 482 CTIGILMSAPNFVEAVSKDFA 502
CTIGILMSAPNFVEAVSKDFA
Sbjct: 301 CTIGILMSAPNFVEAVSKDFA 321
>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
Length = 505
Score = 358 bits (918), Expect = 8e-99
Identities = 189/493 (38%), Positives = 294/493 (59%), Gaps = 17/493 (3%)
Query: 4 SPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIM 63
SP + L L SLL V+ E + +L++ L ++YN + RPVAN S P+ ++F +S+ Q++
Sbjct: 13 SPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLV 72
Query: 64 DVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFD 123
VDE NQ++ TN+WL+ W D+ L+WN S+Y G + +R P +IWKPDI+LYN+A F
Sbjct: 73 KVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQ 132
Query: 124 ATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM- 182
T L+ +G ++PP IFKSSC IDV +FPFD Q+C +KFGSWSY +DL +
Sbjct: 133 VDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLI 192
Query: 183 -QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 241
++ Y +GEW ++ PG + + Y CC+E YPD+T+++ +RR L+Y +NL+IPC
Sbjct: 193 GSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPC 252
Query: 242 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 301
+LIS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS +PLI +Y TM
Sbjct: 253 LLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTM 312
Query: 302 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 361
I V LS+V+TV VL H+ P MP W + + LN + M RP ++ + Q
Sbjct: 313 IFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNE-----GNAQ 367
Query: 362 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV--HC----VPTPDSGVVCGRMACSPT 415
+ L E+S + + G+ DG+ +C + + R + S +
Sbjct: 368 KPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSES 427
Query: 416 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 475
D L PE + + ++ V+YIA + Q+E++ + +WK+ A V+DR+ L F
Sbjct: 428 VDAVLSLSALSPE----IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVF 483
Query: 476 SVFTIICTIGILM 488
++ I+ T G+ +
Sbjct: 484 TLVCILGTAGLFL 496
>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
(neuronal) [Homo sapiens]
Length = 529
Score = 357 bits (916), Expect = 1e-98
Identities = 193/488 (39%), Positives = 277/488 (56%), Gaps = 46/488 (9%)
Query: 24 EFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWT 83
E + +L+K L + YN RPV N S + V F LS+ Q++DVDEKNQ++TTN+WL+ W+
Sbjct: 57 ETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS 116
Query: 84 DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP 143
D+ L+WN +++ + ++R P IW PDI+LYN+AD F T T + S+G ++PP
Sbjct: 117 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPP 176
Query: 144 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE--ADISGYIPNGEWDLVGI 201
I+KSSC IDV +FPFD Q+CK+KFGSW+Y +DL+ E D+ Y +GEW +V
Sbjct: 177 AIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNA 236
Query: 202 PGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEK 261
G + + Y+CC E YPDVT+ +RR L+Y +NL+IPC+LIS L +LVF LP+D GEK
Sbjct: 237 TGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEK 296
Query: 262 ISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHD 321
I+L I+VLLSLTVF+LL+ EI+P+TS +PLI +Y TMI V LS+V+TV VL HH
Sbjct: 297 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS 356
Query: 322 PDGGKMPKWTRVILLNWCAWFLRMKRPGED-------KVRPACQHKQRRCSLASVEMSAV 374
P MP W R LL +L M RP +++ + + ++ + E V
Sbjct: 357 PSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVV 416
Query: 375 APPP---ASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGD- 430
A G++ P G +C HL G P+ +
Sbjct: 417 VEEEDRWACAGHV---------------APSVGTLCSH--------GHLHSGASGPKAEA 453
Query: 431 ----------PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI 480
P + K LE V YIA+ R +D +V +WK+ A V+DR+ L F +
Sbjct: 454 LLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCF 513
Query: 481 ICTIGILM 488
+ TIG+ +
Sbjct: 514 LGTIGLFL 521
>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
Length = 498
Score = 337 bits (863), Expect = 2e-92
Identities = 182/471 (38%), Positives = 277/471 (58%), Gaps = 26/471 (5%)
Query: 26 QRKLYKELVKN--YNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWT 83
+ KL +L+ YN L RP + SQ +++ LSL Q++ V+E+ Q++TTN+WL+ WT
Sbjct: 27 EEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWT 86
Query: 84 DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP 143
D+ L WN S Y GV +R P +IW PDI+LYN+AD ++ + +TN++V S+G +LPP
Sbjct: 87 DYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPP 146
Query: 144 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE--ADISGYIPNGEWDLVGI 201
I+KS+C I+V++FPFD Q+C LKF SW+Y +D+ + A + + P+GEWD+V +
Sbjct: 147 AIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVAL 206
Query: 202 PGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEK 261
PG+R+ + Y DVT+ ++R+ L+Y +NL+IPCVL + LA+LVF LP+D GEK
Sbjct: 207 PGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEK 263
Query: 262 ISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHD 321
++L I+VLL+LT F+LL+++I+P TS VPLI +Y TM++V S+V +V VL HH
Sbjct: 264 MTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRS 323
Query: 322 PDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPAS- 380
P M W + L+ FL MKRPG D PA + + E +A + P++
Sbjct: 324 PSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS-SPARAFPPSKSCVTKPEATATSTSPSNF 382
Query: 381 NGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT---HDEHLLHGGQPPEGDPDLAKIL 437
GN +Y P S +P D L G+ + D+ + L
Sbjct: 383 YGNSMYF-----------VNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQ---DVQEAL 428
Query: 438 EEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488
E V +IA + DE ++V +WK+ A VVDRL L F ++ T+G+ +
Sbjct: 429 EGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL 479
>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
Length = 494
Score = 331 bits (848), Expect = 1e-90
Identities = 175/490 (35%), Positives = 278/490 (56%), Gaps = 30/490 (6%)
Query: 8 VWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDE 67
+WL + + + +L+ +L +YN RPV N S P+TV+F +++ Q+ +VDE
Sbjct: 16 LWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDE 75
Query: 68 KNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFH 127
NQ++ TN+WL+ W D+ L+W+ EY G++T+R P +IWKPDI+LYN+A F
Sbjct: 76 VNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGK 135
Query: 128 TNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM--QEA 185
T L+ +G + PP IFKSSC +D+ +FPFD Q+C LKFGSW+Y +DL + +
Sbjct: 136 TKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKV 195
Query: 186 DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLIS 245
D++ + N EW+++ G + + Y CC+E Y D+T++ +RR ++Y +NL+IPC+ IS
Sbjct: 196 DMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFIS 255
Query: 246 ALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVG 305
L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS VPL+ +Y TMI V
Sbjct: 256 FLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVT 315
Query: 306 LSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRP-------GEDKVRPACQ 358
LS+VVTV VL H+ P MP+W + + L L M+ P G D V
Sbjct: 316 LSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLA 375
Query: 359 HKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDE 418
+ + L AS+G ++ + HC + + R++ P
Sbjct: 376 RRPAKGKL------------ASHGEPRHL----KECFHCHKSNELATSKRRLSHQP---- 415
Query: 419 HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVF 478
L + E P++ ++ V++IA + +E++ V +WK+ A VVDR+ L F +
Sbjct: 416 -LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIV 474
Query: 479 TIICTIGILM 488
+ T G+ +
Sbjct: 475 CVFGTAGLFL 484
>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
precursor [Homo sapiens]
Length = 627
Score = 329 bits (843), Expect = 4e-90
Identities = 170/380 (44%), Positives = 233/380 (61%), Gaps = 6/380 (1%)
Query: 7 GVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVD 66
G L A+S HV + + +L K+L YN RPVAN S + V F LS+ Q++DVD
Sbjct: 20 GTGLLRASS--HVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVD 77
Query: 67 EKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATF 126
EKNQ++TTN+W++ W D+ L+W+ ++Y V ++R P IW+PDI+LYN+AD F T
Sbjct: 78 EKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTH 137
Query: 127 HTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL--QMQE 184
T + G Q+ PP I+KSSC IDV +FPFD Q+C +KFGSW+Y +DL
Sbjct: 138 LTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSR 197
Query: 185 ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 244
D + +GEW +V G + R YECC E YPD+T+ +RR L+Y +NL+IPC+LI
Sbjct: 198 VDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLI 257
Query: 245 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 304
S L +LVF LP++ GEKI+L I+VLLSLTVF+LL+ EI+P+TS +PLI +Y TMI V
Sbjct: 258 SCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFV 317
Query: 305 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG--EDKVRPACQHKQR 362
LS+V+TV VL HH P MP W R + L+ L MKRP +D R + +
Sbjct: 318 TLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHK 377
Query: 363 RCSLASVEMSAVAPPPASNG 382
S PPA++G
Sbjct: 378 MASAPRFWPEPEGEPPATSG 397
Score = 47.4 bits (111), Expect = 3e-05
Identities = 19/58 (32%), Positives = 36/58 (62%)
Query: 431 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488
P L + +E V+YIA+ + +D +V +WK+ A V+DR+ L F + ++ T+G+ +
Sbjct: 562 PALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
precursor [Homo sapiens]
Length = 502
Score = 328 bits (841), Expect = 7e-90
Identities = 175/495 (35%), Positives = 279/495 (56%), Gaps = 27/495 (5%)
Query: 2 RCSPGGVWLALAASLLHVSLQG-EFQRKLYKELV--KNYNPLERPVANDSQPLTVYFSLS 58
RC P + L L + G + + +L + L+ YN L RP N S+ +TV +S
Sbjct: 4 RCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVS 63
Query: 59 LLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSA 118
L Q++ V E+ Q++TTN+WL W D+ L W E+ +K VR P IW PD++LYN+A
Sbjct: 64 LAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNA 123
Query: 119 DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 178
D ++ +F++N +V+ G +LPP I+KS+C I+V+ FPFD Q+C +KF SW+Y +
Sbjct: 124 DGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEI 183
Query: 179 DLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLN 236
DL ++ A + + P+GEWD+V +PG+R+E + Y D+T+ +RR+ L+Y +N
Sbjct: 184 DLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITYDFIIRRKPLFYTIN 240
Query: 237 LLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQY 296
L+IPCVLI++LA+LVF LP+D GEK++L I+VLL+LTVF+LL+++I+P TS VPL+ +Y
Sbjct: 241 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY 300
Query: 297 FASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPA 356
TM++V S+V +V VL HH P M W +V+ L L M++P R
Sbjct: 301 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR 360
Query: 357 CQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTH 416
+ ++R+ P ++ ++ + G + G P
Sbjct: 361 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQG-----------LAGAFGAEPAP 409
Query: 417 DEHLLHGGQPPEGDP---DLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 473
G G+P L + ++ VR+IA+ R +D+ ++V +WK+ A V+DRL L
Sbjct: 410 -----VAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLW 464
Query: 474 AFSVFTIICTIGILM 488
F + TIG+ +
Sbjct: 465 IFVFVCVFGTIGMFL 479
>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
sapiens]
Length = 450
Score = 328 bits (841), Expect = 7e-90
Identities = 183/471 (38%), Positives = 262/471 (55%), Gaps = 49/471 (10%)
Query: 22 QGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMS 81
+G KL+++L NY RPVA+ Q L V ++L QI+D+DE+NQVLT +W++
Sbjct: 26 EGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQE 85
Query: 82 WTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYL 141
WTD YL+W+ + Y G+ +R P +W+PDI+LYN AD + + TNV++ G ++
Sbjct: 86 WTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWD 145
Query: 142 PPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ--EADISGYIPNGEWDLV 199
P I +SSC +DV FPFD QHC L FGSW++GG LD++ + A ++ ++ N EW ++
Sbjct: 146 APAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVL 205
Query: 200 GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSG 259
G+P +R Y CC EPYPDVTFT+ +RRR Y NLL+PCVLIS LA L F LPADSG
Sbjct: 206 GMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSG 265
Query: 260 EKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHH 319
EK+SLG+TVLL+LTVF LL+AE MP ++SVPLI +Y+ +TM +V S +T++++ H+
Sbjct: 266 EKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIMNLHY 324
Query: 320 HDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPA 379
P +P W R +LL A L ++ GE P Q + S + A PPA
Sbjct: 325 CGPSVRPVPAWARALLLGHLARGLCVRERGE----PCGQSRPPELSPSPQSPEGGAGPPA 380
Query: 380 SNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEE 439
P + +C E LLH
Sbjct: 381 G------------------PCHEPRCLC--------RQEALLH----------------H 398
Query: 440 VRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490
V IAN FR ++ +WK A V+DR L F ++ ++ +L+ A
Sbjct: 399 VATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449
>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
[Homo sapiens]
Length = 479
Score = 322 bits (825), Expect = 5e-88
Identities = 179/497 (36%), Positives = 276/497 (55%), Gaps = 45/497 (9%)
Query: 9 WLALAASLLHVS--LQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVD 66
W+ AAS L + G++ +KL+ +L ++Y+ RPV + + L V ++L QI D+D
Sbjct: 12 WIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMD 71
Query: 67 EKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATF 126
E+NQ+LT +W++ W D YL W+ +Y G+ ++R P +W+PDI+LYN AD+
Sbjct: 72 ERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPV 131
Query: 127 HTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL--QMQE 184
+TNV++ G + P I KSSC +DV +FPFD Q C L FGSW+Y G +D+ +
Sbjct: 132 NTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDS 191
Query: 185 ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 244
D+S +I + EW++ G+P ++ Y CC EPYPDVTFT+ ++RR+ +Y +NLLIPCVLI
Sbjct: 192 GDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLI 251
Query: 245 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 304
S LA L F LPA SGEK+SLG+T+LL++TVF L+VAEIMPA S++VPLI +Y+ +TM ++
Sbjct: 252 SFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALI 310
Query: 305 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 364
S +T++V+ H + +P W RV++L + + L + GE + P H + R
Sbjct: 311 TASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP--HHSRERD 368
Query: 365 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR---MACSPTHDEHL- 420
L V P+S + R ++ ++ L
Sbjct: 369 HLTKVYSK---------------------------LPESNLKAARNKDLSRKKDMNKRLK 401
Query: 421 ----LHGGQPPEGDPDLAK---ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 473
G P E + A+ + + YIA + + + SEWK A V+DR +
Sbjct: 402 NDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMW 461
Query: 474 AFSVFTIICTIGILMSA 490
F + + TI I+ A
Sbjct: 462 IFFIMVFVMTILIIARA 478
>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
precursor [Homo sapiens]
Length = 457
Score = 314 bits (804), Expect = 1e-85
Identities = 171/477 (35%), Positives = 266/477 (55%), Gaps = 62/477 (12%)
Query: 21 LQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQM 80
L E + +L +L K+Y+ + RPV + Q + V L L+Q+++VDE NQ++TTN+ L+
Sbjct: 19 LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78
Query: 81 SWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQY 140
W D+ L+WN +Y GVK + P +IW+PD++LYN+AD F T VL+ +GH +
Sbjct: 79 QWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITW 138
Query: 141 LPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGG--WSLDLQMQEADISGYIPNGEWDL 198
PP IFKS C I V FPFD Q+C +K G+W+Y G +++ + + D+S ++ +GEW +
Sbjct: 139 TPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVI 198
Query: 199 VGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD 257
G + Y CC + PY D+T+ M+R LY+ +N++IPC+L S L LVF LP D
Sbjct: 199 KESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTD 258
Query: 258 SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQY 317
SGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI +Y TM+ V S+++TVIV+
Sbjct: 259 SGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINT 318
Query: 318 HHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAV 374
HH P MP W R + ++ +F MKRP +K + ++ +++S +
Sbjct: 319 HHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREK-------QDKKIFTEDIDISDI 371
Query: 375 A----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGD 430
+ PPP +GF H + H
Sbjct: 372 SGKPGPPP--------MGF--------------------------HSPLIKH-------- 389
Query: 431 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGIL 487
P++ +E ++YIA + ES +EWK+ A V+D + L VF ++C IG L
Sbjct: 390 PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILL---GVFMLVCIIGTL 443
>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
precursor [Homo sapiens]
Length = 482
Score = 300 bits (768), Expect = 2e-81
Identities = 171/502 (34%), Positives = 266/502 (52%), Gaps = 87/502 (17%)
Query: 21 LQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQM 80
L E + +L +L K+Y+ + RPV + Q + V L L+Q+++VDE NQ++TTN+ L+
Sbjct: 19 LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78
Query: 81 S-------------------------WTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLY 115
W D+ L+WN +Y GVK + P +IW+PD++LY
Sbjct: 79 GDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLY 138
Query: 116 NSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGG 175
N+AD F T VL+ +GH + PP IFKS C I V FPFD Q+C +K G+W+Y G
Sbjct: 139 NNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDG 198
Query: 176 W--SLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLY 232
+++ + + D+S ++ +GEW + G + Y CC + PY D+T+ M+R LY
Sbjct: 199 SVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLY 258
Query: 233 YGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPL 292
+ +N++IPC+L S L LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPL
Sbjct: 259 FIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPL 318
Query: 293 IAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPG 349
I +Y TM+ V S+++TVIV+ HH P MP W R + ++ +F MKRP
Sbjct: 319 IGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPS 378
Query: 350 EDKVRPACQHKQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGV 405
+K + ++ +++S ++ PPP +GF
Sbjct: 379 REK-------QDKKIFTEDIDISDISGKPGPPP--------MGF---------------- 407
Query: 406 VCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAAC 465
H + H P++ +E ++YIA + ES +EWK+ A
Sbjct: 408 ----------HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAM 449
Query: 466 VVDRLCLMAFSVFTIICTIGIL 487
V+D + L VF ++C IG L
Sbjct: 450 VMDHILL---GVFMLVCIIGTL 468
>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
[Homo sapiens]
Length = 458
Score = 287 bits (735), Expect = 1e-77
Identities = 161/473 (34%), Positives = 249/473 (52%), Gaps = 56/473 (11%)
Query: 24 EFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWT 83
E + L + L + Y RPV + + + VYF L + Q++DVDEKNQ++TTN+WL+ WT
Sbjct: 27 ENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWT 86
Query: 84 DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP 143
DH L+WN +Y G+ +++ P +W PDI+L+ +AD RF+ + T V+V S+G + PP
Sbjct: 87 DHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPP 146
Query: 144 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM--QEADISGYIPNGEWDLV-- 199
+KSSC +DV +FPFD Q+C +KFGSW+Y G +DL + + D + NGEW+++
Sbjct: 147 ASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNA 206
Query: 200 -GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADS 258
G+ G R + Y YP +T++ +RR L+Y L L+IPC+ +S L +LVF LP+D
Sbjct: 207 KGMKGNRRDGVYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 261
Query: 259 GEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYH 318
GEK+SL +VL+SLTVF+L++ EI+P++S +PLI +Y MI V LS++VTV V+ H
Sbjct: 262 GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVH 321
Query: 319 HHDPDG-GKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPP 377
H M W + + L L MK + P + Q +E
Sbjct: 322 HRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKK--KQK 379
Query: 378 PASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKIL 437
S+G + + F L K
Sbjct: 380 QLSDGEKVLVAF-------------------------------------------LEKAA 396
Query: 438 EEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490
+ +RYI+ + + V +WKF A V+DR+ L F + ++ ++ I A
Sbjct: 397 DSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPA 449
>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
Length = 468
Score = 278 bits (710), Expect = 1e-74
Identities = 133/320 (41%), Positives = 204/320 (63%), Gaps = 5/320 (1%)
Query: 2 RCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQ 61
RC G L S + + L K+L ++Y RPV + + + + F L++ Q
Sbjct: 23 RCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQ 82
Query: 62 IMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADER 121
++DVDEKNQ++TTN+WL+ W D L+WN +Y G+K +R P +W PDI+L+++AD R
Sbjct: 83 LVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGR 142
Query: 122 FDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 181
F+ T T ++ +G + PP +KSSC IDV +FPFD+Q+C +KFGSW+Y G +D+
Sbjct: 143 FEGT-STKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDII 201
Query: 182 MQEADIS--GYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 239
+++ D+ + NGEW++V G + R CC PY VT++ ++R L+Y L L+I
Sbjct: 202 LEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLII 259
Query: 240 PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 299
PC+ +S L +LVF LP++ GEKI L +VL+SLTVF+L++ EI+P++S +PLI +Y
Sbjct: 260 PCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVF 319
Query: 300 TMIIVGLSVVVTVIVLQYHH 319
TMI V LS++VTV + HH
Sbjct: 320 TMIFVTLSIMVTVFAINIHH 339
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/74 (28%), Positives = 35/74 (47%)
Query: 415 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA 474
T E G P L L+ +RYI +++ V +WKF A V+DR+ L
Sbjct: 375 TQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWT 434
Query: 475 FSVFTIICTIGILM 488
F +I+ ++G+ +
Sbjct: 435 FLFVSIVGSLGLFV 448
>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
precursor [Homo sapiens]
Length = 501
Score = 270 bits (691), Expect = 2e-72
Identities = 167/518 (32%), Positives = 271/518 (52%), Gaps = 60/518 (11%)
Query: 4 SPGGVWL---ALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL 60
+PG + + AL A L E + +L ++L Y+ RP + V L L
Sbjct: 2 TPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILA 61
Query: 61 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120
Q++ ++EK++ ++T ++L + WTD+ L W+ +E+ G+ ++R +W PD++L N+ D
Sbjct: 62 QLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDG 121
Query: 121 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL 180
FD +V+V+S G ++ PPGI++SSC I V +FPFD Q+C + F S+SY + L
Sbjct: 122 NFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSL 181
Query: 181 QM---------QEADI--SGYIPNGEWDLVGIPGKRSERFYECCKEPY-------PDVTF 222
Q QE I +I NG+W+++ P R + +P +V F
Sbjct: 182 QTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPS----RLIQPPGDPRGGREGQRQEVIF 237
Query: 223 TVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEI 282
+ +RR+ L+Y +N++ PC+LI+ LA+ VF LP D+GEK+ L I LL+LTVF+LL+A+
Sbjct: 238 YLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADK 297
Query: 283 MPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWF 342
+P TS SVP+I +Y TM++V SV+++V+VL HH P +MP W R I ++ +
Sbjct: 298 VPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLY 357
Query: 343 LRMKRPGEDK----VRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCV 398
LR+KRP ++ P C + E PP + L+
Sbjct: 358 LRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPP----SDFLF------------ 401
Query: 399 PTPD------SGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDE 452
P P+ S R P LL P+L +++ + YIA + + Q++
Sbjct: 402 PKPNRFQPELSAPDLRRFIDGPNRAVALL---------PELREVVSSISYIARQLQEQED 452
Query: 453 SEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490
+A+ +W+F A VVDRL L F +FT + T+ I + A
Sbjct: 453 HDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDA 490
>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
precursor [Homo sapiens]
Length = 517
Score = 251 bits (642), Expect = 8e-67
Identities = 156/477 (32%), Positives = 241/477 (50%), Gaps = 31/477 (6%)
Query: 27 RKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHY 86
R L++E K YN RPVA+ + + V +L+L ++ + E + LTTN+W++ WTD+
Sbjct: 30 RHLFQE--KGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNR 87
Query: 87 LQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIF 146
L+WN E+ + +R P +W P+I+L N+ D F ++ NVLV G +LPP IF
Sbjct: 88 LKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIF 147
Query: 147 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE--------------ADISGYIP 192
+SSC I V +FPFD Q+C LKF S Y + L +++ D G+
Sbjct: 148 RSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTE 207
Query: 193 NGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLV 251
NGEW++V P + + P D+TF + +RR+ L+Y +N+L+PCVLIS + LV
Sbjct: 208 NGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLV 267
Query: 252 FLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVT 311
F LPADSGEK S+ I+VLL+ +VF+LL+++ +PATS ++PLI ++ M++V + VV+
Sbjct: 268 FYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVIC 327
Query: 312 VIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEM 371
VIVL H P + + + + L L M RP ED P +R SL +
Sbjct: 328 VIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGAL-VRRSSSLGYISK 386
Query: 372 SAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDP 431
+ S +L++ G+ T R S + L
Sbjct: 387 AEEYFLLKSRSDLMFEKQSERHGLARRLT-----TARRPPASSEQAQQELFN-------- 433
Query: 432 DLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488
+L ++ +I N R Q+ W A VDRLCL + ++ T I +
Sbjct: 434 ELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFL 490
>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
precursor [Homo sapiens]
Length = 517
Score = 234 bits (597), Expect = 1e-61
Identities = 163/514 (31%), Positives = 250/514 (48%), Gaps = 50/514 (9%)
Query: 6 GGVWLALAASLLHVSL--QGEFQR-KLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQI 62
GG L LL V L QG Q +L +L++NY+P RP DS + V L+L +
Sbjct: 3 GGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNL 62
Query: 63 MDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERF 122
+ ++E+ + LTTN+W++M W D+ L+W+ +Y G+ +R P +W+PDI+L N+ D F
Sbjct: 63 ISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVF 122
Query: 123 DATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM 182
+ + NVLV+ G +LPP IF+S+C I V +FPFD Q+C L F S +Y +DLQ+
Sbjct: 123 EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL 182
Query: 183 QE----------ADISGYIPNGEWDLVGIPGKR-SERFYECCKEPYPDVTFTVTMRRRTL 231
+ D + NGEW + P K + + + V F + ++R+ L
Sbjct: 183 SQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPL 242
Query: 232 YYGLNLLIPCVLISALALLVFLLPADS-GEKISLGITVLLSLTVFMLLVAEIMPATSDSV 290
+Y +N++ PCVLIS++A+L+ LPA + G+K ++ I VLL+ TVF+ LVA+ +P TS +V
Sbjct: 243 FYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAV 302
Query: 291 PLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE 350
PLI++Y +++ L VV V+VL P M + R + L LRM
Sbjct: 303 PLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM----- 357
Query: 351 DKVRP----ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD---- 402
VRP A Q Q R NG+ + G + C+P +
Sbjct: 358 -HVRPLAPAAVQDTQSR---------------LQNGSSGWSITTGEEVALCLPRSELLFQ 401
Query: 403 ----SGVVCGRMACSPTHDEHLLHG--GQPPEGDPDLAKILEEVRYIANRFRCQDESEAV 456
G+V + E L G + P + +E IA Q +
Sbjct: 402 QWQRQGLVAAALEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNG 461
Query: 457 CSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490
EW V+DR+C +A I T GI + A
Sbjct: 462 NEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMA 495
>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
precursor [Homo sapiens]
Length = 493
Score = 221 bits (563), Expect = 1e-57
Identities = 148/505 (29%), Positives = 243/505 (48%), Gaps = 49/505 (9%)
Query: 1 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL 60
M +P GV L L LL + + +LY L NY+P RPV +T+ ++L
Sbjct: 1 MARAPLGVLLLLG--LLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLT 58
Query: 61 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120
++ ++EK + LTT++W+ + W D+ L ++ ++ G++T+R P +W P+I+L N+ D
Sbjct: 59 NLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDG 118
Query: 121 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLD- 179
+F + NVLV G +LPP I++S C ++V +FPFD Q+C L F S +Y ++
Sbjct: 119 QFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEF 178
Query: 180 ----------LQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRR 228
+ + D Y NGEW + PG P DV +++ +RR
Sbjct: 179 TFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRR 238
Query: 229 RTLYYGLNLLIPCVLISALALLVFLLPADS-GEKISLGITVLLSLTVFMLLVAEIMPATS 287
+ L+Y +N+++PCVLIS L LL + LPA + G+K ++ I VLL+ TVF+ L+A+ +P TS
Sbjct: 239 KPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETS 298
Query: 288 DSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKR 347
SVPL+ ++ M++ L V+ VIVL P M R +LL L
Sbjct: 299 LSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPP 358
Query: 348 PGEDKVRPACQHKQRRCSLASVEMSA---VAPPPASNGNLLYIGFRGLDGVHCVPTPDSG 404
P E P RR S + + A + P S L++ G R G +
Sbjct: 359 PPE---APRAASPPRRASSVGLLLRAEELILKKPRS--ELVFEGQRHRQGTW------TA 407
Query: 405 VVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAA 464
C + + P++ ++ V ++A R Q+ + S+W
Sbjct: 408 AFCQSLGAAA----------------PEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMG 451
Query: 465 CVVDRLC----LMAFSVFTIICTIG 485
+D +C L+ FSV + + +G
Sbjct: 452 NALDNICFWAALVLFSVGSSLIFLG 476
>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
precursor [Homo sapiens]
Length = 484
Score = 208 bits (530), Expect = 8e-54
Identities = 144/499 (28%), Positives = 235/499 (47%), Gaps = 57/499 (11%)
Query: 11 ALAASLLHVSL-QGEFQR----------KLYKELVKNYNPLERPVANDSQPLTVYFSLSL 59
AL A LL L QGE +R +L L+ NY RPV + +P TV + +
Sbjct: 14 ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73
Query: 60 LQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSAD 119
I++VDEKNQVLTT IW + WTD +LQWN ++ + + P IW PDIL+ D
Sbjct: 74 YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133
Query: 120 ERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLD 179
V + G Q P ++C +D+ FPFDVQ+C L F SW + ++
Sbjct: 134 VGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192
Query: 180 LQMQ------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYY 233
+ + ++D S ++ GEW+L+G+ E E Y ++ F V +RRR L+Y
Sbjct: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFY 251
Query: 234 GLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI 293
++LL+P + + + ++ F LP +SGE++S IT+LL +VF+++V++ +PAT+ PLI
Sbjct: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311
Query: 294 AQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKV 353
YF M ++ +S+ T+ +++ H +P W R ++L AW L ++ +
Sbjct: 312 GVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQR 371
Query: 354 RPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMA 411
PA + +++ G HC + P R
Sbjct: 372 PPATSQATKTDDCSAM------------------------GNHCSHMGGPQDFEKSPRDR 407
Query: 412 CSPTHDEHLLHGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDR 469
CSP PP + LA +L+E+ I +DE V +W V+D+
Sbjct: 408 CSPP----------PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDK 457
Query: 470 LCLMAFSVFTIICTIGILM 488
L + + + +I ++M
Sbjct: 458 LLFHIYLLAVLAYSITLVM 476
>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
[Homo sapiens]
Length = 463
Score = 207 bits (526), Expect = 2e-53
Identities = 134/471 (28%), Positives = 224/471 (47%), Gaps = 46/471 (9%)
Query: 28 KLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYL 87
+L L+ NY RPV + +P TV + + I++VDEKNQVLTT IW + WTD +L
Sbjct: 21 RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80
Query: 88 QWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFK 147
QWN ++ + + P IW PDIL+ D V + G Q P
Sbjct: 81 QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNI-PYVYIRHQGEVQNYKPLQVV 139
Query: 148 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ------EADISGYIPNGEWDLVGI 201
++C +D+ FPFDVQ+C L F SW + +++ + ++D S ++ GEW+L+G+
Sbjct: 140 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 199
Query: 202 PGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEK 261
E E Y ++ F V +RRR L+Y ++LL+P + + + ++ F LP +SGE+
Sbjct: 200 LPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 258
Query: 262 ISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHD 321
+S IT+LL +VF+++V++ +PAT+ PLI YF M ++ +S+ T+ +++ H
Sbjct: 259 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQ 318
Query: 322 PDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASN 381
+P W R ++L AW L ++ + PA + +++
Sbjct: 319 DLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM------------ 366
Query: 382 GNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAK--IL 437
G HC + P R CSP PP + LA +L
Sbjct: 367 ------------GNHCSHMGGPQDFEKSPRDRCSPP----------PPPREASLAVCGLL 404
Query: 438 EEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488
+E+ I +DE V +W V+D+L + + + +I ++M
Sbjct: 405 QELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 455
>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
precursor [Homo sapiens]
Length = 516
Score = 193 bits (490), Expect = 3e-49
Identities = 144/531 (27%), Positives = 236/531 (44%), Gaps = 89/531 (16%)
Query: 11 ALAASLLHVSL-QGEFQR----------KLYKELVKNYNPLERPVANDSQPLTVYFSLSL 59
AL A LL L QGE +R +L L+ NY RPV + +P TV + +
Sbjct: 14 ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73
Query: 60 LQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSAD 119
I++VDEKNQVLTT IW + WTD +LQWN ++ + + P IW PDIL+ D
Sbjct: 74 YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133
Query: 120 ERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLD 179
V + G Q P ++C +D+ FPFDVQ+C L F SW + ++
Sbjct: 134 VGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192
Query: 180 LQM------QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYY 233
+ + ++D S ++ GEW+L+G+ E E Y ++ F V +RRR L+Y
Sbjct: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFY 251
Query: 234 GLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI 293
++LL+P + + + ++ F LP +SGE++S IT+LL +VF+++V++ +PAT+ PLI
Sbjct: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311
Query: 294 AQ--------------------------------YFASTMIIVGLSVVVTVIVLQYHHHD 321
+ YF M ++ +S+ T+ +++ H
Sbjct: 312 GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQ 371
Query: 322 PDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASN 381
+P W R ++L AW L ++ + PA + +++
Sbjct: 372 DLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM------------ 419
Query: 382 GNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLA--KIL 437
G HC + P R CSP PP + LA +L
Sbjct: 420 ------------GNHCSHMGGPQDFEKSPRDRCSP----------PPPPREASLAVCGLL 457
Query: 438 EEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488
+E+ I +DE V +W V+D+L + + + +I ++M
Sbjct: 458 QELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508
>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
[Homo sapiens]
Length = 441
Score = 162 bits (411), Expect = 5e-40
Identities = 97/306 (31%), Positives = 161/306 (52%), Gaps = 13/306 (4%)
Query: 29 LYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQ 88
L K+L++ Y+ RPV N ++ TVY L + I+DVD +NQ+L T++W Q W D +L
Sbjct: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
Query: 89 WNVSEYPGVKTVRFPDGQIWKPDILLYNSAD-ERF-DATFHTNVLVNSSGHCQYLPPGIF 146
WN S + ++ + P IW PDI++ D ER+ D + V VNSSG + P
Sbjct: 95 WNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY---VYVNSSGTIENYKPIQV 151
Query: 147 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEA------DISGYIPNGEWDLVG 200
S+C ++ FPFDVQ+C L F S + +DL + D ++ + EW+L+
Sbjct: 152 VSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLS 211
Query: 201 IPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGE 260
+ S + + + F V MRR L Y ++LLIP + + + L F LP +
Sbjct: 212 VSSTYS--ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA 269
Query: 261 KISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHH 320
+I +VL+ TVF + ++ +P + S PLI +F M + LS+ +++++++ H
Sbjct: 270 RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHD 329
Query: 321 DPDGGK 326
+ GG+
Sbjct: 330 EQRGGQ 335
>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
Length = 471
Score = 150 bits (380), Expect = 2e-36
Identities = 95/305 (31%), Positives = 157/305 (51%), Gaps = 15/305 (4%)
Query: 42 RPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVR 101
RPV N S P V S ++ I+DV+E+ +L++ +WL+M W + ++ WN E G+ +
Sbjct: 70 RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
Query: 102 FPDGQIWKPDILLYNSADERFDAT-FHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFD 160
+W PDI + D D T V++ G +Y P S C +D+ +FPFD
Sbjct: 130 MAAKNLWLPDIFIIELMD--VDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFD 187
Query: 161 VQHCKLKFGSWSYGGWSLDLQMQE-----ADISGYI--PNGEWDLVGIPGKRSERFYECC 213
Q+C L F S+ Y S+ L M++ D S I +GEW+L+G+ ++
Sbjct: 188 QQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGL--SKATAKLSRG 245
Query: 214 KEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLT 273
Y + F V +RRR Y +NLL+P + A+ L F LP SG ++ IT+LL
Sbjct: 246 GNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYN 305
Query: 274 VFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKWTR 332
VF+L++++++P + PLI YFA + ++ S++ T+ + H +P+W
Sbjct: 306 VFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLH 363
Query: 333 VILLN 337
+LL+
Sbjct: 364 SLLLH 368
>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
Length = 447
Score = 148 bits (373), Expect = 1e-35
Identities = 97/304 (31%), Positives = 154/304 (50%), Gaps = 13/304 (4%)
Query: 42 RPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVR 101
RP N S P V S +L I+ VD + Q+LT+ +W+ + W + ++ WN E G+ +
Sbjct: 55 RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
Query: 102 FPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDV 161
+W PDI + S D + T ++S G +Y P S C +D+ +FPFD
Sbjct: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
Query: 162 QHCKLKFGSWSYGGWSLDLQMQE-----ADISGYI--PNGEWDLVGIPGKRSERFYECCK 214
Q+C F S+ Y S+ L M + D S + GEW+L+GI ++
Sbjct: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGI--NKATPKMSMGN 231
Query: 215 EPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTV 274
Y + F V +RRR Y +NLL+P + A+ L F LPA+S + IT+LL V
Sbjct: 232 NLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNV 291
Query: 275 FMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV-IVLQYHHHDPDGGKMPKWTRV 333
F+L++ +++PA+ PLI+ YFA + ++ +S++ TV I H MP+W
Sbjct: 292 FLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHS 349
Query: 334 ILLN 337
+LL+
Sbjct: 350 LLLH 353
>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
Length = 412
Score = 77.8 bits (190), Expect = 2e-14
Identities = 67/276 (24%), Positives = 125/276 (45%), Gaps = 23/276 (8%)
Query: 46 NDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDG 105
N S PL V + + + +VD +++ + L++SW D L WN S +P + P
Sbjct: 55 NGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWE 113
Query: 106 QIWKPDILLYNS--ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQH 163
+W P + + + D R + V+ GH + +++C ++ FP D +
Sbjct: 114 SLWTPRLTILEALWVDWRDQSP---QARVDQDGHVKLNLALATETNCNFELLHFPRDHSN 170
Query: 164 CKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVT-- 221
C L F ++L E + ++ N ++V + KR Y+ + P
Sbjct: 171 CSLSF-------YALSNTAMELEFQAHVVN---EIVSV--KREYVVYDLKTQVPPQQLVP 218
Query: 222 -FTVTMRRRT--LYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLL 278
F VT+R + L + LL+P + + LLP + E+I +T+LLS V
Sbjct: 219 CFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSS 278
Query: 279 VAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIV 314
+ + +P++S PL+ YF ++++ LS + TV++
Sbjct: 279 LVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLL 314
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 74.7 bits (182), Expect = 2e-13
Identities = 76/322 (23%), Positives = 137/322 (42%), Gaps = 20/322 (6%)
Query: 7 GVWL--ALAASLLHVSLQGEFQRKLYKE----LVKNYNPLERPVANDSQPLTVYFSLSLL 60
G+W + A++ S+ L KE L+K Y+ RP P+ V ++ +
Sbjct: 11 GIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFG-GPPVAVGMNIDIA 69
Query: 61 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120
I V E N T ++ Q +W D L +NV R D Q+W PD N
Sbjct: 70 SIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVAD-QLWVPDTYFLNDKKS 128
Query: 121 RFDATFHTNVLV--NSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 178
N ++ + G Y ++C +D+R +P D Q+C L+ S+ Y +
Sbjct: 129 FVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDI 188
Query: 179 DLQMQEAD--ISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLN 236
+ + D ++G + K + YP ++ + ++R Y+ L
Sbjct: 189 EFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQ 248
Query: 237 LLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 295
+P +LI+ L+ + F + D S +++LGIT +L++T + E +P +P +
Sbjct: 249 TYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLP----KIPYVK- 303
Query: 296 YFASTMIIVGLSVVVTVIVLQY 317
A M ++G V V + +L+Y
Sbjct: 304 --AIDMYLMGCFVFVFMALLEY 323
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 74.7 bits (182), Expect = 2e-13
Identities = 76/322 (23%), Positives = 137/322 (42%), Gaps = 20/322 (6%)
Query: 7 GVWL--ALAASLLHVSLQGEFQRKLYKE----LVKNYNPLERPVANDSQPLTVYFSLSLL 60
G+W + A++ S+ L KE L+K Y+ RP P+ V ++ +
Sbjct: 11 GIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFG-GPPVAVGMNIDIA 69
Query: 61 QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120
I V E N T ++ Q +W D L +NV R D Q+W PD N
Sbjct: 70 SIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVAD-QLWVPDTYFLNDKKS 128
Query: 121 RFDATFHTNVLV--NSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 178
N ++ + G Y ++C +D+R +P D Q+C L+ S+ Y +
Sbjct: 129 FVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDI 188
Query: 179 DLQMQEAD--ISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLN 236
+ + D ++G + K + YP ++ + ++R Y+ L
Sbjct: 189 EFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQ 248
Query: 237 LLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 295
+P +LI+ L+ + F + D S +++LGIT +L++T + E +P +P +
Sbjct: 249 TYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLP----KIPYVK- 303
Query: 296 YFASTMIIVGLSVVVTVIVLQY 317
A M ++G V V + +L+Y
Sbjct: 304 --AIDMYLMGCFVFVFMALLEY 323
>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
sapiens]
Length = 440
Score = 73.2 bits (178), Expect = 5e-13
Identities = 65/278 (23%), Positives = 111/278 (39%), Gaps = 20/278 (7%)
Query: 30 YKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYL-- 87
++ L YN RP +P+ + +L + I + E N T I+L+ W D L
Sbjct: 41 FENLTAGYNKFLRPNFG-GEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVF 99
Query: 88 QWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVN--SSGHCQYLPPGI 145
+ N S + V F +W PD + S N L+ S+G Y
Sbjct: 100 EGNKSFTLDARLVEF----LWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRIT 155
Query: 146 FKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKR 205
+C +D+ +P D Q CKL+ SW Y G ++ + G + + +
Sbjct: 156 TTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTW----LRGNDSVRGLEHLRLAQYT 211
Query: 206 SERFYECCKEP------YPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADS- 258
ER++ Y + +RR LY+ L +P + L+ + F + DS
Sbjct: 212 IERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSV 271
Query: 259 GEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQY 296
+ +G+T +LS+T M+ +P T+ + I Y
Sbjct: 272 PARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVY 309
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 72.4 bits (176), Expect = 9e-13
Identities = 68/299 (22%), Positives = 125/299 (41%), Gaps = 19/299 (6%)
Query: 29 LYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQ 88
+ L++ Y+ RP +P ++ + + I V+ N T +I+ +W D L+
Sbjct: 69 ILNNLLEGYDNKLRPDIG-VKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLK 127
Query: 89 WNVSEYPGVKTVRFPD---GQIWKPDILLYNS--ADERFDATFHTNVLVNSSGHCQYLPP 143
+N + +K +R G+IW PD NS AD + T + + + + G Y
Sbjct: 128 FNST----IKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLR 183
Query: 144 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNG----EWDLV 199
+ C + + FP D C L+F S+ Y + Q + + + ++ V
Sbjct: 184 LTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFV 243
Query: 200 GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADS- 258
G+ + + + Y ++ + RR Y+ + IPC LI L+ + F + D+
Sbjct: 244 GL--RNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAV 301
Query: 259 GEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQY 317
+ SLGIT +L++T + + +P S + F S I S +V L Y
Sbjct: 302 PARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM--DLFVSVCFIFVFSALVEYGTLHY 358
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,355,914
Number of Sequences: 37866
Number of extensions: 1011359
Number of successful extensions: 2727
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 2555
Number of HSP's gapped (non-prelim): 113
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.