Search of human proteins with 4502827

Search of human proteins with 4502827

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
precursor [Homo sapiens]
         (627 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...  1295   0.0  
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   580   e-165
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   488   e-138
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    475   e-134
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   419   e-117
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   417   e-116
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   402   e-112
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   399   e-111
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   385   e-107
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     382   e-106
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   329   5e-90
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   317   3e-86
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   296   3e-80
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   295   9e-80
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   285   9e-77
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   283   3e-76
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   276   3e-74
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              226   4e-59
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   212   1e-54
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   211   2e-54
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   196   4e-50
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              171   2e-42
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   161   2e-39
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   159   7e-39
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   152   7e-37
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...    81   3e-15
gi|4504023 glycine receptor, beta [Homo sapiens]                       81   3e-15
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...    80   4e-15
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...    78   3e-14
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...    77   6e-14

>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score = 1295 bits (3352), Expect = 0.0
 Identities = 627/627 (100%), Positives = 627/627 (100%)

Query: 1   MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD 60
           MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD
Sbjct: 1   MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD 60

Query: 61  VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR 120
           VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR
Sbjct: 61  VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR 120

Query: 121 PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG 180
           PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG
Sbjct: 121 PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG 180

Query: 181 SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR 240
           SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR
Sbjct: 181 SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR 240

Query: 241 RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS 300
           RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS
Sbjct: 241 RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS 300

Query: 301 LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR 360
           LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR
Sbjct: 301 LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR 360

Query: 361 PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP 420
           PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP
Sbjct: 361 PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP 420

Query: 421 SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG 480
           SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG
Sbjct: 421 SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG 480

Query: 481 GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV 540
           GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV
Sbjct: 481 GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV 540

Query: 541 SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR 600
           SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR
Sbjct: 541 SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR 600

Query: 601 IFLWMFIIVCLLGTVGLFLPPWLAGMI 627
           IFLWMFIIVCLLGTVGLFLPPWLAGMI
Sbjct: 601 IFLWMFIIVCLLGTVGLFLPPWLAGMI 627


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  580 bits (1496), Expect = e-165
 Identities = 287/373 (76%), Positives = 309/373 (82%), Gaps = 9/373 (2%)

Query: 4   GGPGAPRLLP-----PLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANI 58
           GG  A R  P     PL     T L +  SH ET    E+RL K LF GYN+W+RPV N 
Sbjct: 25  GGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTET----EDRLFKHLFRGYNRWARPVPNT 80

Query: 59  SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELI 118
           SDVV+VRFGLSIAQLIDVDEKNQMMTTNVW+KQEW DYKLRW+P D+ N+TS+R+PSE+I
Sbjct: 81  SDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMI 140

Query: 119 WRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK 178
           W PDIVLYNNADG+FAVTH+TKAHLF  G V W PPAIYKSSCSIDVTFFPFDQQNC MK
Sbjct: 141 WIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMK 200

Query: 179 FGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFV 238
           FGSWTYDKAKIDL  M   VD  D+WESGEW IV+A GTYN++KY+CCAEIYPD+TYAFV
Sbjct: 201 FGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFV 260

Query: 239 IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPS 298
           IRRLPLFYTINLIIPCLLISCLTVLVFYLPS+CGEKITLCISVLLSLTVFLLLITEIIPS
Sbjct: 261 IRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPS 320

Query: 299 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLM 358
           TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP THTMP WVR   L  VPR LLM
Sbjct: 321 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLM 380

Query: 359 KRPSVVKDNCRRL 371
            RP    + C  L
Sbjct: 381 NRPPPPVELCHPL 393



 Score =  119 bits (297), Expect = 1e-26
 Identities = 55/70 (78%), Positives = 63/70 (90%)

Query: 558 LPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGL 617
           L LSP + +A+EGV YIADHL++ED D SVKEDWKYVAMVIDRIFLW+FIIVC LGT+GL
Sbjct: 460 LLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGL 519

Query: 618 FLPPWLAGMI 627
           FLPP+LAGMI
Sbjct: 520 FLPPFLAGMI 529


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  488 bits (1257), Expect = e-138
 Identities = 238/360 (66%), Positives = 289/360 (80%), Gaps = 3/360 (0%)

Query: 11  LLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70
           L PP LLLL   LL +   V   + AE RL ++LF  YN+  RPVAN+SD V++ F +S+
Sbjct: 12  LSPPRLLLL---LLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSM 68

Query: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130
           +QL+ VDE NQ+M TN+W+KQ W+DYKL+W+P+DY     +R+P++ IW+PDIVLYNNA 
Sbjct: 69  SQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAV 128

Query: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKID 190
           GDF V   TKA L + G V W PPAI+KSSC IDVT+FPFD QNCTMKFGSW+YDKAKID
Sbjct: 129 GDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKID 188

Query: 191 LVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINL 250
           LV + S ++  D+WESGEW I+ A G  +  KY CC EIYPDITY+  IRRLPLFYTINL
Sbjct: 189 LVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINL 248

Query: 251 IIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYL 310
           IIPCLLIS LTVLVFYLPS+CGEK+TLCISVLLSLTVFLL+ITE IPSTSLVIPLIGEYL
Sbjct: 249 IIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYL 308

Query: 311 LFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRR 370
           LFTMIFVTLSIVITVFVLNVH+R+P THTMP+WV+ VFL+++PR++ M RP+  + N ++
Sbjct: 309 LFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQK 368



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 37/65 (56%), Positives = 53/65 (81%)

Query: 560 LSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
           LSP +  A++ V+YIA+++KA++    +++DWKYVAMVIDRIFLW+F +VC+LGT GLFL
Sbjct: 437 LSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFL 496

Query: 620 PPWLA 624
            P +A
Sbjct: 497 QPLMA 501


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  475 bits (1223), Expect = e-134
 Identities = 220/325 (67%), Positives = 272/325 (83%)

Query: 37  EERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDY 96
           EERL  KLFS YN++ RPV N+SD V V F ++I QL +VDE NQ+M TN+W++  W+DY
Sbjct: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93

Query: 97  KLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAI 156
           KLRWDP +Y+ + ++R+P++ IW+PDIVLYNNA GDF V   TKA L ++G + WTPPAI
Sbjct: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153

Query: 157 YKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVG 216
           +KSSC +D+TFFPFD QNC++KFGSWTYDKA+IDL+ + S+VD  DFWE+ EW I+DA G
Sbjct: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213

Query: 217 TYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKIT 276
             +  KY CC EIY DITY+F IRRLP+FYTINLIIPCL IS LTVLVFYLPS+CGEK+T
Sbjct: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273

Query: 277 LCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR 336
           LCISVLLSLTVFLL+ITE IPSTSLV+PL+GEYLLFTMIFVTLSIV+TVFVLN+H+R+P 
Sbjct: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333

Query: 337 THTMPTWVRRVFLDIVPRLLLMKRP 361
           THTMP WV+ VFL ++P++LLM+ P
Sbjct: 334 THTMPRWVKTVFLKLLPQVLLMRWP 358



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 34/63 (53%), Positives = 48/63 (76%)

Query: 561 SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLP 620
           SP +   +  VQ+IA+++K+ +    V++DWKYVAMV+DR+FLW+FIIVC+ GT GLFL 
Sbjct: 426 SPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQ 485

Query: 621 PWL 623
           P L
Sbjct: 486 PLL 488


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  419 bits (1076), Expect = e-117
 Identities = 212/364 (58%), Positives = 269/364 (73%), Gaps = 12/364 (3%)

Query: 5   GPGAPRLLPPLLLLLGT--------GLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVA 56
           GP A RLL  + L+ G         G  R  S   + A  E+ LLK LF  Y +W RPV 
Sbjct: 7   GPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVE 66

Query: 57  NISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSE 116
           +++D + ++FGL+I+QL+DVDEKNQ+MTTNVW+KQEW D KLRW+P DY  +  IR+PS+
Sbjct: 67  HLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSD 126

Query: 117 LIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCT 176
            +W PDIVL++NADG F  T  TK  + ++G V WTPPA YKSSC+IDVTFFPFD QNC+
Sbjct: 127 SVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCS 185

Query: 177 MKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYA 236
           MKFGSWTYD +++D++     VD+ DF+++GEW IV A G+   R   CC   YP +TY+
Sbjct: 186 MKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCW--YPYVTYS 243

Query: 237 FVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEII 296
           FVI+RLPLFYT+ LIIPC+ +S LTVLVFYLPS  GEKI LC SVL+SLTVFLL+I EII
Sbjct: 244 FVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEII 303

Query: 297 PSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTH-TMPTWVRRVFLDIVPRL 355
           PS+S VIPLIGEYL+FTMIFVTLSI++TVF +N+HHRS  TH  M   VR++FL  +P+L
Sbjct: 304 PSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKL 363

Query: 356 LLMK 359
           L M+
Sbjct: 364 LCMR 367



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 25/57 (43%), Positives = 41/57 (71%)

Query: 564 LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLP 620
           L  A++ ++YI  H+  E+    V EDWK++A V+DR+FLW F+ V ++G++GLF+P
Sbjct: 393 LEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVP 449


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  417 bits (1073), Expect = e-116
 Identities = 208/347 (59%), Positives = 268/347 (77%), Gaps = 4/347 (1%)

Query: 15  LLLLLGTGL-LRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQL 73
           +L+L+  G+   A++   + A  E+ LL+ LF GY KW RPV + +D + V FGL I+QL
Sbjct: 6   MLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQL 65

Query: 74  IDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDF 133
           +DVDEKNQ+MTTNVW+KQEW D+KLRW+P DY  + SI++PSE +W PDIVL+ NADG F
Sbjct: 66  VDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRF 125

Query: 134 AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVN 193
             + +TK  +  +G V WTPPA YKSSC++DVTFFPFD+QNC+MKFGSWTYD   +DL+ 
Sbjct: 126 EGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLIL 185

Query: 194 MHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIP 253
           ++  VD+ DF+++GEW I++A G    R+    +  YP ITY+FV+RRLPLFYT+ LIIP
Sbjct: 186 INENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIP 243

Query: 254 CLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT 313
           CL +S LTVLVFYLPS+ GEK++L  SVL+SLTVFLL+I EIIPS+S VIPLIGEYLLF 
Sbjct: 244 CLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFI 303

Query: 314 MIFVTLSIVITVFVLNVHHRSPRT-HTMPTWVRRVFLDIVPRLLLMK 359
           MIFVTLSI++TVFV+NVHHRS  T H M  WV+R+FL  +P+LL MK
Sbjct: 304 MIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK 350



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 27/57 (47%), Positives = 41/57 (71%)

Query: 564 LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLP 620
           L +A + ++YI+ H+K E     V +DWK+VA V+DRIFLW+F+IV + G+V +F P
Sbjct: 392 LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTP 448


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  402 bits (1033), Expect = e-112
 Identities = 208/360 (57%), Positives = 263/360 (73%), Gaps = 11/360 (3%)

Query: 14  PLLLLLGTGLLRASSHVETRAHAEERLLKKLF--SGYNKWSRPVANISDVVLVRFGLSIA 71
           P+ LLLG GLLR  S V      EERL++ L   S YNK  RP  N S++V V+  +S+A
Sbjct: 7   PVALLLGFGLLRLCSGV-WGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLA 65

Query: 72  QLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADG 131
           QLI V E+ Q+MTTNVW+ QEW DY+L W P +++N+  +R+PS+ IW PD+VLYNNADG
Sbjct: 66  QLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADG 125

Query: 132 DFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL 191
            + V+  + A + +DG + W PPAIYKS+C I+V  FPFDQQNCTMKF SWTYD+ +IDL
Sbjct: 126 MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL 185

Query: 192 VNMHSRVDQL-DFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINL 250
           V + S V  L DF  SGEW IV   G  N    +     Y DITY F+IRR PLFYTINL
Sbjct: 186 V-LKSEVASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITYDFIIRRKPLFYTINL 241

Query: 251 IIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYL 310
           IIPC+LI+ L +LVFYLPS+CGEK+TLCISVLL+LTVFLLLI++I+P TSL +PL+G+YL
Sbjct: 242 IIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYL 301

Query: 311 LFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRR 370
           +FTM+ VT SIV +V VLNVHHRSP THTM  WV+ VFL+ +P LL M++P   + +C R
Sbjct: 302 MFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQP---RHHCAR 358



 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 53/125 (42%), Positives = 71/125 (56%), Gaps = 14/125 (11%)

Query: 501 EADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATV--KTRSTKAPPPHL 558
           + + + AGAL  R    A+           CTC    +SV   A       +  A P   
Sbjct: 367 QREREGAGALFFREAPGAD----------SCTCFVNRASVQGLAGAFGAEPAPVAGPGRS 416

Query: 559 --PLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVG 616
             P    L  AV+GV++IADH+++ED D SV EDWKYVAMVIDR+FLW+F+ VC+ GT+G
Sbjct: 417 GEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIG 476

Query: 617 LFLPP 621
           +FL P
Sbjct: 477 MFLQP 481


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  399 bits (1026), Expect = e-111
 Identities = 206/384 (53%), Positives = 263/384 (68%), Gaps = 14/384 (3%)

Query: 14  PLLLLLG---TGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70
           PLLLL      GL+  S H       E RL+ KLF  Y+   RPV +   VV V  GL +
Sbjct: 5   PLLLLFSLCSAGLVLGSEH-------ETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57

Query: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130
            QLI+VDE NQ++TTNV +KQ+W DY L+W+P DY  V  I IPSE IWRPD+VLYNNAD
Sbjct: 58  IQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD 117

Query: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKID 190
           GDFA+   TK  L + G + WTPPAI+KS C I VT FPFD+QNC+MK G+WTYD + + 
Sbjct: 118 GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVA 177

Query: 191 LVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEI-YPDITYAFVIRRLPLFYTIN 249
           +     + D  +F ESGEWVI ++ G  ++  Y CC +  Y DITY FV++RLPL++ +N
Sbjct: 178 INPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVN 237

Query: 250 LIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEY 309
           +IIPCLL S LT LVFYLP++ GEK+TL ISVLLSLTVFLL+I E+IPSTS  +PLIG+Y
Sbjct: 238 VIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKY 297

Query: 310 LLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLL---MKRPSVVKD 366
           +LFTM+FV  SI+ITV V+N HHRSP TH MP WVR+VF+D +P ++    MKRPS  K 
Sbjct: 298 MLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQ 357

Query: 367 NCRRLIESMHKMASAPRFWPEPEG 390
           + +   E +     + +  P P G
Sbjct: 358 DKKIFTEDIDISDISGKPGPPPMG 381



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 30/70 (42%), Positives = 48/70 (68%), Gaps = 5/70 (7%)

Query: 554 PPP---HLPL--SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFII 608
           PPP   H PL   P +  A+EG++YIA+ +K++    +   +WKYVAMV+D I L +F++
Sbjct: 377 PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436

Query: 609 VCLLGTVGLF 618
           VC++GT+ +F
Sbjct: 437 VCIIGTLAVF 446


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  385 bits (990), Expect = e-107
 Identities = 206/409 (50%), Positives = 263/409 (64%), Gaps = 39/409 (9%)

Query: 14  PLLLLLG---TGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70
           PLLLL      GL+  S H       E RL+ KLF  Y+   RPV +   VV V  GL +
Sbjct: 5   PLLLLFSLCSAGLVLGSEH-------ETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57

Query: 71  AQLIDVDEKNQMMTTNVWVKQ-------------------------EWHDYKLRWDPADY 105
            QLI+VDE NQ++TTNV +KQ                         +W DY L+W+P DY
Sbjct: 58  IQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDY 117

Query: 106 ENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDV 165
             V  I IPSE IWRPD+VLYNNADGDFA+   TK  L + G + WTPPAI+KS C I V
Sbjct: 118 GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIV 177

Query: 166 TFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYEC 225
           T FPFD+QNC+MK G+WTYD + + +     + D  +F ESGEWVI ++ G  ++  Y C
Sbjct: 178 THFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSC 237

Query: 226 CAEI-YPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLS 284
           C +  Y DITY FV++RLPL++ +N+IIPCLL S LT LVFYLP++ GEK+TL ISVLLS
Sbjct: 238 CPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS 297

Query: 285 LTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWV 344
           LTVFLL+I E+IPSTS  +PLIG+Y+LFTM+FV  SI+ITV V+N HHRSP TH MP WV
Sbjct: 298 LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWV 357

Query: 345 RRVFLDIVPRLLL---MKRPSVVKDNCRRLIESMHKMASAPRFWPEPEG 390
           R+VF+D +P ++    MKRPS  K + +   E +     + +  P P G
Sbjct: 358 RKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMG 406



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 30/70 (42%), Positives = 48/70 (68%), Gaps = 5/70 (7%)

Query: 554 PPP---HLPL--SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFII 608
           PPP   H PL   P +  A+EG++YIA+ +K++    +   +WKYVAMV+D I L +F++
Sbjct: 402 PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 461

Query: 609 VCLLGTVGLF 618
           VC++GT+ +F
Sbjct: 462 VCIIGTLAVF 471


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  382 bits (980), Expect = e-106
 Identities = 193/349 (55%), Positives = 244/349 (69%), Gaps = 12/349 (3%)

Query: 15  LLLLLGTGLLRASSHVETRAHAEERLLKKLFSG--YNKWSRPVANISDVVLVRFGLSIAQ 72
           L+ L G G  R        A+AEE+L+  L +   YN   RP  + S ++ ++  LS+AQ
Sbjct: 12  LVALCGRGNCRV-------ANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQ 64

Query: 73  LIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGD 132
           LI V+E+ Q+MTTNVW+KQEW DY+L W+ + YE V  +RIP++ IW PDIVLYNNADG 
Sbjct: 65  LISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGT 124

Query: 133 FAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLV 192
           + V+  T   +  +G V W PPAIYKS+C I+V +FPFDQQNCT+KF SWTYD  +ID+V
Sbjct: 125 YEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMV 184

Query: 193 NMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLII 252
            M       DF  SGEW IV   G       +     Y D+TY F+I+R PLFYTINLII
Sbjct: 185 LMTPTASMDDFTPSGEWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLII 241

Query: 253 PCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLF 312
           PC+L + L +LVFYLPS+CGEK+TLCISVLL+LT FLLLI++I+P TSL +PLIG+YL+F
Sbjct: 242 PCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMF 301

Query: 313 TMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRP 361
           TM+ VT SIV +V VLNVHHRSP THTM  WV+R FL  +P  L MKRP
Sbjct: 302 TMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRP 350



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 39/55 (70%), Positives = 48/55 (87%)

Query: 567 AVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPP 621
           A+EGV +IA H+K +D D SV EDWKYVAMV+DR+FLW+F+ VC+LGTVGLFLPP
Sbjct: 427 ALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPP 481


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  329 bits (843), Expect = 5e-90
 Identities = 170/380 (44%), Positives = 233/380 (61%), Gaps = 6/380 (1%)

Query: 20  GTGLLRASS--HVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVD 77
           G  L  A+S  HV  +   + +L K+L   YN   RPVAN S  + V F LS+ Q++DVD
Sbjct: 7   GVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVD 66

Query: 78  EKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTH 137
           EKNQ++TTN+W++  W D+ L+W+ ++Y  V ++R P   IW+PDI+LYN+AD  F  T 
Sbjct: 67  EKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATF 126

Query: 138 LTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSR 197
            T   +   G  Q+ PP I+KSSC IDV +FPFD Q+C +KFGSW+Y    +DL      
Sbjct: 127 HTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL--QMQE 184

Query: 198 VDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLI 257
            D   +  +GEW +V   G  + R YECC E YPD+T+   +RR  L+Y +NL+IPC+LI
Sbjct: 185 ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 244

Query: 258 SCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFV 317
           S L +LVF LP++ GEKI+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +Y   TMI V
Sbjct: 245 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 304

Query: 318 TLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHK 377
            LS+V+TV VL  HH  P    MP W R + L+     L MKRP   +D  R   +   +
Sbjct: 305 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG--EDKVRPACQHKQR 362

Query: 378 MASAPRFWPEPEGEPPATSG 397
             S           PPA++G
Sbjct: 363 RCSLASVEMSAVAPPPASNG 382



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 19/58 (32%), Positives = 36/58 (62%)

Query: 562 PALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
           P L + +E V+YIA+  + +D   +V  +WK+ A V+DR+ L  F +  ++ T+G+ +
Sbjct: 431 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  317 bits (811), Expect = 3e-86
 Identities = 164/376 (43%), Positives = 235/376 (62%), Gaps = 29/376 (7%)

Query: 12  LPPLLLLLGTGLLRASSHVETR-AHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70
           + P  LL+  G L A      R + AE RL +KLFSGY+   RP   + D V V  GL +
Sbjct: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60

Query: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130
           AQLI ++EK++ M+T V++  EW DY+L WDPA+++ + S+RI +E +W PD+VL NN D
Sbjct: 61  AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND 120

Query: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKID 190
           G+F V       +  DG V+W PP IY+SSCSI VT+FPFD QNCTM F S++YD +++ 
Sbjct: 121 GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS 180

Query: 191 LV---------NMHSRVDQLDFWESGEWVIV-----------DAVGTYNTRKYECCAEIY 230
           L          +    + +  F E+G+W I+           D  G    ++ E      
Sbjct: 181 LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQE------ 234

Query: 231 PDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLL 290
             + +  +IRR PLFY +N+I PC+LI+ L + VFYLP + GEK+ L I  LL+LTVFLL
Sbjct: 235 --VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLL 292

Query: 291 LITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLD 350
           L+ + +P TSL +P+I +YL+FTM+ VT S++++V VLN+HHRSP TH MP WVR++F+ 
Sbjct: 293 LLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIH 352

Query: 351 IVPRLLLMKRPSVVKD 366
            +P  L +KRP   +D
Sbjct: 353 KLPLYLRLKRPKPERD 368



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 40/122 (32%), Positives = 59/122 (48%), Gaps = 9/122 (7%)

Query: 500 PEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSP--SATVKTRSTKAPPPH 557
           P      +G     + +    PP D   P       +P+   P  SA    R    P   
Sbjct: 374 PHCSSPGSGWGRGTDEYFIRKPPSDFLFP-------KPNRFQPELSAPDLRRFIDGPNRA 426

Query: 558 LPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGL 617
           + L P L   V  + YIA  L+ ++   ++KEDW++VAMV+DR+FLW FII   +GT+ +
Sbjct: 427 VALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486

Query: 618 FL 619
           FL
Sbjct: 487 FL 488


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  296 bits (759), Expect = 3e-80
 Identities = 149/341 (43%), Positives = 221/341 (64%), Gaps = 15/341 (4%)

Query: 37  EERLLKKLFS--GYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWH 94
           EERL++ LF   GYNK  RPVA+  + V V   L+++ LI + E  + +TTNVW++  W 
Sbjct: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84

Query: 95  DYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPP 154
           D +L+W+  ++ N++ +R+P +++W P+IVL NN DG F +++     ++H G V W PP
Sbjct: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144

Query: 155 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSR------------VDQLD 202
           AI++SSC I VT+FPFD QNC++KF S  Y   +I L                  +D   
Sbjct: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204

Query: 203 FWESGEWVIVDAVGTYNTR-KYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLT 261
           F E+GEW IV      N   +    +    DIT+  +IRR PLFY IN+++PC+LIS + 
Sbjct: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264

Query: 262 VLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSI 321
            LVFYLP++ GEK ++ ISVLL+ +VFLLLI++ +P+TS+ IPLIG++LLF M+ VT+ +
Sbjct: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324

Query: 322 VITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPS 362
           VI V VLN+H R+P TH +   V+++FL+ +P LL M RP+
Sbjct: 325 VICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPA 365



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 32/127 (25%), Positives = 54/127 (42%), Gaps = 7/127 (5%)

Query: 500 PEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLP 559
           P  DG + GAL  R++    +   ++    K          S    +  R T A  P   
Sbjct: 364 PAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPAS 423

Query: 560 LSPA-------LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLL 612
              A       L  AV+G  +I +H++ ++     K+ W  VA  +DR+ L++   V ++
Sbjct: 424 SEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVV 483

Query: 613 GTVGLFL 619
           GT  +FL
Sbjct: 484 GTAWIFL 490


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  295 bits (755), Expect = 9e-80
 Identities = 138/321 (42%), Positives = 204/321 (63%), Gaps = 1/321 (0%)

Query: 38  ERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYK 97
           ++L   LF  Y+   RPV +   V+ V   ++++Q+ D+DE+NQ++T  +W++Q WHD  
Sbjct: 32  QKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAY 91

Query: 98  LRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIY 157
           L WD   Y+ + SIRIPS+L+WRPDIVLYN AD + +    T   L +DG + W  PAI 
Sbjct: 92  LTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAIT 151

Query: 158 KSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGT 217
           KSSC +DVT+FPFD Q C + FGSWTY+  ++D+ N     D  DF E  EW +      
Sbjct: 152 KSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAV 211

Query: 218 YNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITL 277
            N   Y CC+E YPD+T+  +++R   FY +NL+IPC+LIS L  L FYLP+  GEK++L
Sbjct: 212 KNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSL 271

Query: 278 CISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRT 337
            +++LL++TVF L++ EI+P++  V PLIG+Y + TM  +T S  +T+ V+N+H      
Sbjct: 272 GVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEA 330

Query: 338 HTMPTWVRRVFLDIVPRLLLM 358
             +P W R V L  + R+L +
Sbjct: 331 RPVPHWARVVILKYMSRVLFV 351



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/52 (44%), Positives = 30/52 (57%), Gaps = 3/52 (5%)

Query: 564 LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTV 615
           LTR +E   YIA  LK      S   +WK VA VIDR F+W+F I+  + T+
Sbjct: 424 LTRNIE---YIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  285 bits (729), Expect = 9e-77
 Identities = 136/321 (42%), Positives = 201/321 (62%), Gaps = 1/321 (0%)

Query: 39  RLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKL 98
           +L + LF+ Y    RPVA+    + V   ++++Q+ID+DE+NQ++T  +W++QEW D  L
Sbjct: 32  KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYL 91

Query: 99  RWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYK 158
           RWDP  Y  + +IRIPS L+WRPDIVLYN AD     +  T   L HDG V+W  PAI +
Sbjct: 92  RWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITR 151

Query: 159 SSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTY 218
           SSC +DV  FPFD Q+C + FGSWT+   ++D+    +     DF E+ EW ++      
Sbjct: 152 SSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARR 211

Query: 219 NTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLC 278
               Y CC+E YPD+T+  ++RR    Y  NL++PC+LIS L  L F+LP++ GEK++L 
Sbjct: 212 RVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLG 271

Query: 279 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTH 338
           ++VLL+LTVF LL+ E +P    V PLIG+Y + TM  VT S  +T+ ++N+H+  P   
Sbjct: 272 VTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVR 330

Query: 339 TMPTWVRRVFLDIVPRLLLMK 359
            +P W R + L  + R L ++
Sbjct: 331 PVPAWARALLLGHLARGLCVR 351



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 6/92 (6%)

Query: 524 DQPSPCKCTCKKEPSSVSPSATVKTRSTKAP--PPHLPLSPALTRAV-EGVQYIADHLKA 580
           ++  PC    +  P  +SPS          P  P H P       A+   V  IA+  ++
Sbjct: 352 ERGEPCG---QSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRS 408

Query: 581 EDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLL 612
                   EDWK +A V+DR FL +F  + L+
Sbjct: 409 HRAAQRCHEDWKRLARVMDRFFLAIFFSMALV 440


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  283 bits (724), Expect = 3e-76
 Identities = 159/372 (42%), Positives = 221/372 (59%), Gaps = 18/372 (4%)

Query: 14  PLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQL 73
           PLLLLL   LL      + R + EERLL  L   Y+   RP    SDVV V   L++  L
Sbjct: 7   PLLLLL---LLAVCLGAQGR-NQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNL 62

Query: 74  IDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDF 133
           I ++E+ + +TTNVW++ +W DY+LRWDP DYE +  +R+PS ++WRPDIVL NN DG F
Sbjct: 63  ISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVF 122

Query: 134 AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVN 193
            V       +  DG + W PPAI++S+CSI VT+FPFD QNC++ F S TY   +IDL  
Sbjct: 123 EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL 182

Query: 194 MHSR--------VDQLDFWESGEWVIVDAVGTYNTRKYECCAEI-YPDITYAFVIRRLPL 244
                       +D   F E+GEW I                E  +  + +  +I+R PL
Sbjct: 183 SQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPL 242

Query: 245 FYTINLIIPCLLISCLTVLVFYLPSEC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVI 303
           FY IN+I PC+LIS + +L+ +LP++  G+K T+ I+VLL+ TVFL L+ + +P TS  +
Sbjct: 243 FYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAV 302

Query: 304 PLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMK---- 359
           PLI +YL F ++   L +V  V VLNV  RSP TH+M   VR+VFL ++P+LL M     
Sbjct: 303 PLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPL 362

Query: 360 RPSVVKDNCRRL 371
            P+ V+D   RL
Sbjct: 363 APAAVQDTQSRL 374



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 17/59 (28%), Positives = 28/59 (47%)

Query: 561 SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
           +PA+   VE    IA     +    +  E+W  V  V+DR+     + + + GT G+FL
Sbjct: 435 APAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFL 493


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  276 bits (707), Expect = 3e-74
 Identities = 146/356 (41%), Positives = 220/356 (61%), Gaps = 19/356 (5%)

Query: 14  PLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQL 73
           PL +LL  GLL          + E RL   LF+ Y+  SRPV    D V +   +++  L
Sbjct: 5   PLGVLLLLGLLGRG----VGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL 60

Query: 74  IDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDF 133
           I ++EK + +TT+VW+  +W DY+L +   D+  + ++R+PSEL+W P+IVL NN DG F
Sbjct: 61  ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF 120

Query: 134 AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLV- 192
            V +     ++  G V W PPAIY+S C+++VT+FPFD QNC++ F S TY+  +++   
Sbjct: 121 GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF 180

Query: 193 ---NMHSRVDQLD-----FWESGEWVIVDAVGTYNTRKYECCAEIYP---DITYAFVIRR 241
              N    ++++D     + E+GEW I    G    R++   A   P   D+ Y+ +IRR
Sbjct: 181 AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGV--IRRHHGGATDGPGETDVIYSLIIRR 238

Query: 242 LPLFYTINLIIPCLLISCLTVLVFYLPSEC-GEKITLCISVLLSLTVFLLLITEIIPSTS 300
            PLFY IN+I+PC+LIS L +L ++LP++  G+K T+ I+VLL+ TVFL LI + IP TS
Sbjct: 239 KPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETS 298

Query: 301 LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLL 356
           L +PL+G +L+F M+  TL ++  V VLNV  R+P TH M   +R V L+++PRLL
Sbjct: 299 LSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL 354



 Score = 30.0 bits (66), Expect = 6.7
 Identities = 12/59 (20%), Positives = 29/59 (49%)

Query: 561 SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
           +P +   V+ V ++A+  + ++       DW  +   +D I  W  +++  +G+  +FL
Sbjct: 417 APEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFL 475


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  226 bits (577), Expect = 4e-59
 Identities = 121/269 (44%), Positives = 160/269 (59%), Gaps = 4/269 (1%)

Query: 129 ADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAK 188
           AD  F  T  T   +   G  Q+ PP I+KSSC IDV +FPFD Q+C +KFGSW+Y    
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87

Query: 189 IDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTI 248
           +DL       D   +  +GEW +V   G  + R YECC E YPD+T+   +RR  L+Y +
Sbjct: 88  LDL--QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145

Query: 249 NLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGE 308
           NL+IPC+LIS L +LVF LP++ GEKI+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +
Sbjct: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205

Query: 309 YLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNC 368
           Y   TMI V LS+V+TV VL  HH  P    MP W R + L+     L MKRP   +D  
Sbjct: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG--EDKV 263

Query: 369 RRLIESMHKMASAPRFWPEPEGEPPATSG 397
           R   +   +  S           PPA++G
Sbjct: 264 RPACQHKQRRCSLASVEMSAVAPPPASNG 292



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 19/58 (32%), Positives = 36/58 (62%)

Query: 562 PALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
           P L + +E V+YIA+  + +D   +V  +WK+ A V+DR+ L  F +  ++ T+G+ +
Sbjct: 341 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 398


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  212 bits (539), Expect = 1e-54
 Identities = 114/356 (32%), Positives = 197/356 (55%), Gaps = 10/356 (2%)

Query: 11  LLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70
           LL P LL  G     A     T   A  RL   L + Y K  RPV +      V   + +
Sbjct: 18  LLLPTLLAQG----EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73

Query: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130
             +++VDEKNQ++TT +W +Q W D  L+W+P D++N+T + IP++ IW PDI++    D
Sbjct: 74  YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133

Query: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSW--TYDKAK 188
              +  ++   ++ H G VQ   P    ++CS+D+  FPFD QNC++ F SW  T     
Sbjct: 134 VGKS-PNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192

Query: 189 IDLVNMHSRV--DQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFY 246
           I L  +  +V  D+  F   GEW ++  +  +     E  +  Y ++ +  VIRR PLFY
Sbjct: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFY 251

Query: 247 TINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLI 306
            ++L++P + +  + ++ FYLP   GE+++  I++LL  +VFL+++++ +P+T++  PLI
Sbjct: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311

Query: 307 GEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPS 362
           G Y +  M  + +S+  T+F++ + H+      +P W+R + L+ +  LL ++  S
Sbjct: 312 GVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQS 367



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 16/66 (24%), Positives = 31/66 (46%)

Query: 554 PPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLG 613
           PPP    S A+   ++ +  I   L+  D    V  DW  V  V+D++   ++++  L  
Sbjct: 411 PPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAY 470

Query: 614 TVGLFL 619
           ++ L +
Sbjct: 471 SITLVM 476


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  211 bits (537), Expect = 2e-54
 Identities = 109/343 (31%), Positives = 193/343 (56%), Gaps = 6/343 (1%)

Query: 24  LRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMM 83
           L+A     T   A  RL   L + Y K  RPV +      V   + +  +++VDEKNQ++
Sbjct: 6   LQARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVL 65

Query: 84  TTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHL 143
           TT +W +Q W D  L+W+P D++N+T + IP++ IW PDI++    D   +  ++   ++
Sbjct: 66  TTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS-PNIPYVYI 124

Query: 144 FHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSW--TYDKAKIDLVNMHSRV--D 199
            H G VQ   P    ++CS+D+  FPFD QNC++ F SW  T     I L  +  +V  D
Sbjct: 125 RHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSD 184

Query: 200 QLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISC 259
           +  F   GEW ++  +  +     E  +  Y ++ +  VIRR PLFY ++L++P + +  
Sbjct: 185 RSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMV 243

Query: 260 LTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTL 319
           + ++ FYLP   GE+++  I++LL  +VFL+++++ +P+T++  PLIG Y +  M  + +
Sbjct: 244 MDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVI 303

Query: 320 SIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPS 362
           S+  T+F++ + H+      +P W+R + L+ +  LL ++  S
Sbjct: 304 SLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQS 346



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 16/66 (24%), Positives = 31/66 (46%)

Query: 554 PPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLG 613
           PPP    S A+   ++ +  I   L+  D    V  DW  V  V+D++   ++++  L  
Sbjct: 390 PPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAY 449

Query: 614 TVGLFL 619
           ++ L +
Sbjct: 450 SITLVM 455


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  196 bits (499), Expect = 4e-50
 Identities = 114/388 (29%), Positives = 198/388 (51%), Gaps = 42/388 (10%)

Query: 11  LLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70
           LL P LL  G     A     T   A  RL   L + Y K  RPV +      V   + +
Sbjct: 18  LLLPTLLAQG----EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73

Query: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130
             +++VDEKNQ++TT +W +Q W D  L+W+P D++N+T + IP++ IW PDI++    D
Sbjct: 74  YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133

Query: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSW--TYDKAK 188
              +  ++   ++ H G VQ   P    ++CS+D+  FPFD QNC++ F SW  T     
Sbjct: 134 VGKS-PNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192

Query: 189 IDLVNMHSRV--DQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFY 246
           I L  +  +V  D+  F   GEW ++  +  +     E  +  Y ++ +  VIRR PLFY
Sbjct: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFY 251

Query: 247 TINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLI 306
            ++L++P + +  + ++ FYLP   GE+++  I++LL  +VFL+++++ +P+T++  PLI
Sbjct: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311

Query: 307 GE--------------------------------YLLFTMIFVTLSIVITVFVLNVHHRS 334
           G+                                Y +  M  + +S+  T+F++ + H+ 
Sbjct: 312 GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQ 371

Query: 335 PRTHTMPTWVRRVFLDIVPRLLLMKRPS 362
                +P W+R + L+ +  LL ++  S
Sbjct: 372 DLQQPVPAWLRHLVLERIAWLLCLREQS 399



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 16/66 (24%), Positives = 31/66 (46%)

Query: 554 PPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLG 613
           PPP    S A+   ++ +  I   L+  D    V  DW  V  V+D++   ++++  L  
Sbjct: 443 PPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAY 502

Query: 614 TVGLFL 619
           ++ L +
Sbjct: 503 SITLVM 508


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  171 bits (432), Expect = 2e-42
 Identities = 89/192 (46%), Positives = 119/192 (61%), Gaps = 2/192 (1%)

Query: 206 SGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVF 265
           +GEW +V   G  + R YECC E YPD+T+   +RR  L+Y +NL+IPC+LIS L +LVF
Sbjct: 12  NGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVF 71

Query: 266 YLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITV 325
            LP++ GEKI+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +Y   TMI V LS+V+TV
Sbjct: 72  LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV 131

Query: 326 FVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFW 385
            VL  HH  P    MP W R + L+     L MKRP   +D  R   +   +  S     
Sbjct: 132 IVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG--EDKVRPACQHKQRRCSLASVE 189

Query: 386 PEPEGEPPATSG 397
                 PPA++G
Sbjct: 190 MSAVAPPPASNG 201



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 19/58 (32%), Positives = 36/58 (62%)

Query: 562 PALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
           P L + +E V+YIA+  + +D   +V  +WK+ A V+DR+ L  F +  ++ T+G+ +
Sbjct: 250 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 307


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  161 bits (407), Expect = 2e-39
 Identities = 92/321 (28%), Positives = 173/321 (53%), Gaps = 15/321 (4%)

Query: 36  AEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHD 95
           A+   L  +F+   K  RPV NIS    V    +++ ++DV+E+  ++++ +W++  W +
Sbjct: 55  ADPTALNSVFN--RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDN 112

Query: 96  YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 155
             + W+P + E +T + + ++ +W PDI +    D D     LT A++ ++GR+++  P 
Sbjct: 113 PFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPM 171

Query: 156 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLD------FWESGEW 209
              S C++D+ +FPFDQQNCT+ F S+ Y    + L++M   V ++           GEW
Sbjct: 172 KVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSM-LLDMEKEVWEITDASRNILQTHGEW 230

Query: 210 VIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPS 269
            ++    +  T K      +Y  I +   IRR P  Y INL++P   +  +  L FYLP 
Sbjct: 231 ELLGL--SKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPV 288

Query: 270 ECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN 329
           + G ++   I++LL   VFLL++++++P++    PLIG Y    +  +  S++ T+F+ +
Sbjct: 289 KSGNRVPFKITLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITH 346

Query: 330 -VHHRSPRTHTMPTWVRRVFL 349
            +H  + +   +P W+  + L
Sbjct: 347 LLHVATTQPPPLPRWLHSLLL 367


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  159 bits (402), Expect = 7e-39
 Identities = 94/324 (29%), Positives = 163/324 (50%), Gaps = 8/324 (2%)

Query: 17  LLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDV 76
           +L+  G+L   +H   +  A   L K+L   Y+K  RPV N +    V   L +  ++DV
Sbjct: 13  ILVAAGILATDTH-HPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDV 71

Query: 77  DEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVT 136
           D +NQ++ T+VW ++ W+D  L W+ + ++ +  I +P   IW PDI++    D +    
Sbjct: 72  DAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIE-RYP 130

Query: 137 HLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHS 196
            L   ++   G ++   P    S+CS++   FPFD QNC++ F S  +    +DL  + S
Sbjct: 131 DLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRS 190

Query: 197 ----RVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLII 252
               + D+  F    EW ++    TY+    +  A  +  I +  V+RR PL Y ++L+I
Sbjct: 191 PEDIQHDKKAFLNDSEWELLSVSSTYSI--LQSSAGGFAQIQFNVVMRRHPLVYVVSLLI 248

Query: 253 PCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLF 312
           P + +  + +  FYLP  C  +I    SVL+  TVF + ++  +P +    PLIG +   
Sbjct: 249 PSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTI 308

Query: 313 TMIFVTLSIVITVFVLNVHHRSPR 336
            M F+ LS+  ++ ++   H   R
Sbjct: 309 CMAFLVLSLAKSIVLVKFLHDEQR 332


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  152 bits (385), Expect = 7e-37
 Identities = 88/307 (28%), Positives = 156/307 (50%), Gaps = 19/307 (6%)

Query: 53  RPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIR 112
           RP  N S    V    +++ ++ VD + Q++T+ +W+   W +  + W+P +   +  + 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 113 IPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQ 172
           + +E +W PDI +  + D D   + LT A++  +GR+++  P    S C++D+ +FPFDQ
Sbjct: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173

Query: 173 QNCTMKFGSWTY---------DKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKY 223
           QNCT  F S+ Y         DK   ++ +   +V Q      GEW ++       T K 
Sbjct: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQ----GEWELLGI--NKATPKM 227

Query: 224 ECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLL 283
                +Y  I +   IRR P  Y INL++P   +  +  L FYLP+E   +    I++LL
Sbjct: 228 SMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLL 287

Query: 284 SLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPRTHTMPT 342
              VFLL++ +++P++    PLI  Y    +  + +S++ TVF+   +H  + +   MP 
Sbjct: 288 GYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPR 345

Query: 343 WVRRVFL 349
           W+  + L
Sbjct: 346 WLHSLLL 352


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 76/340 (22%), Positives = 150/340 (44%), Gaps = 20/340 (5%)

Query: 40  LLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLR 99
           +L  L  GY+   RP   +    L+   + +  +  V+  N   T +++  Q W+D +L+
Sbjct: 69  ILNNLLEGYDNKLRPDIGVKPT-LIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLK 127

Query: 100 WDPADYENVTSIRIPSEL---IWRPDIVLYNN--ADGDFAVTHLTKAHLFHDGRVQWTPP 154
           ++      +  +R+ S +   IW PD    N+  AD  +  T      +++DGRV +T  
Sbjct: 128 FN----STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLR 183

Query: 155 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLD--FWESGEWVIV 212
               + C + +  FP D+ +C ++F S+ Y + +I      S V+  D   W   ++  V
Sbjct: 184 LTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFV 243

Query: 213 DAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSEC- 271
               T  T   +  +  Y  ++  F + R   ++TI   IPC LI  L+ + F++  +  
Sbjct: 244 GLRNT--TEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAV 301

Query: 272 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIV----ITVFV 327
             + +L I+ +L++T    +  + +P  S V  +   ++    IFV  ++V    +  FV
Sbjct: 302 PARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM-DLFVSVCFIFVFSALVEYGTLHYFV 360

Query: 328 LNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDN 367
            N      +       + R+F    P + +  R + ++ N
Sbjct: 361 SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMN 400


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 77/309 (24%), Positives = 135/309 (43%), Gaps = 36/309 (11%)

Query: 34  AHAEERLLKKLFSGYNKWSRPVANISDV-VLVRFGLSIAQLIDVDEKNQMMTTNVWVKQE 92
           A++   +L +L   Y+   RP  N   + V V   + I     + E       N++++Q+
Sbjct: 53  ANSTSNILNRLLVSYDPRIRP--NFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQK 110

Query: 93  WHDYKLRWDPADYENVTSIRIPSEL---IWRPDIVLYNNADGDF--AVTHLTKAHLFHDG 147
           W+D +L+  P+D+    ++ +   +   +W+PD+   N    +F           +F DG
Sbjct: 111 WNDPRLKL-PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDG 169

Query: 148 RVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDF-WES 206
            V  +       SC +D+T FP D Q C M+  S+ Y              D L F W+S
Sbjct: 170 DVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGY------------TTDDLRFIWQS 217

Query: 207 GEWVIVD--AVGTYNTRK----YECCAEIYPDITY------AFVIRRLPLFYTINLIIPC 254
           G+ V ++  A+  ++ +K    Y  C + Y    Y       F +RR   FY + +  P 
Sbjct: 218 GDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPT 277

Query: 255 LLISCLTVLVFYL-PSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT 313
           LLI  L+ L F++ P     ++ L I  +LSL      +   +P  S V   +  +L+  
Sbjct: 278 LLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYV-KALDVWLIAC 336

Query: 314 MIFVTLSIV 322
           ++F   S+V
Sbjct: 337 LLFGFASLV 345


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 68/291 (23%), Positives = 133/291 (45%), Gaps = 16/291 (5%)

Query: 40  LLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLR 99
           +L  L  GY+   RP   +    L+   + +  +  V+  N   T +++  Q W+D +L+
Sbjct: 69  ILNNLLEGYDNKLRPDIGVKPT-LIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLK 127

Query: 100 WDPADYENVTSIRIPSEL---IWRPDIVLYNN--ADGDFAVTHLTKAHLFHDGRVQWTPP 154
           ++      +  +R+ S +   IW PD    N+  AD  +  T      +++DGRV +T  
Sbjct: 128 FN----STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLR 183

Query: 155 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLD--FWESGEWVIV 212
               + C + +  FP D+ +C ++F S+ Y + +I      S V+  D   W   ++  V
Sbjct: 184 LTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFV 243

Query: 213 DAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSEC- 271
               T  T   +  +  Y  ++  F + R   ++TI   IPC LI  L+ + F++  +  
Sbjct: 244 GLRNT--TEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAV 301

Query: 272 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIV 322
             + +L I+ +L++T    +  + +P  S V  +   ++    IFV  ++V
Sbjct: 302 PARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM-DLFVSVCFIFVFSALV 351


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 80/335 (23%), Positives = 145/335 (43%), Gaps = 28/335 (8%)

Query: 8   APRLLPPLLLLLGTGLLRASSHVETRAHAEER------------------LLKKLFSGYN 49
           AP+LL  LLL L +GL   S  VE   + +                    +L KL   Y+
Sbjct: 2   APKLL--LLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYD 59

Query: 50  KWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVT 109
           K  RP   I   V +   + +  +  V   N     +++  Q W D +LR++ +  + +T
Sbjct: 60  KKLRPDIGIKPTV-IDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFN-STMKILT 117

Query: 110 SIRIPSELIWRPDIVLYNN--ADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTF 167
                  LIW PD +  N+  A+  +  T      +++DG++ +T      + C + +  
Sbjct: 118 LNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHN 177

Query: 168 FPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRK-YECC 226
           FP D+ +C + F S+ Y K ++      + V+  D  +S      D +G  NT +     
Sbjct: 178 FPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAAD-QKSWRLYQFDFMGLRNTTEIVTTS 236

Query: 227 AEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSEC-GEKITLCISVLLSL 285
           A  Y  +T  F + R   ++TI   IPC+L   L+ + F++  +    +  L I+ +L++
Sbjct: 237 AGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTM 296

Query: 286 TVFLLLITEIIPSTSLVIPL-IGEYLLFTMIFVTL 319
           T    +  + +P  S V  + +   + F  +F  L
Sbjct: 297 TTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAAL 331


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 64/287 (22%), Positives = 128/287 (44%), Gaps = 10/287 (3%)

Query: 39  RLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKL 98
           ++L  L  GY+   RP   +   V +   + +  +  VD  N   T ++   Q W D +L
Sbjct: 66  QILNSLLQGYDNKLRPDIGVRPTV-IETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRL 124

Query: 99  RWDPADYENVTSIRIPSELIWRPDIVLYNN--ADGDFAVTHLTKAHLFHDGRVQWTPPAI 156
           +++      + +  +  + IW PD    N+  +D  +  T      +++DGRV +T    
Sbjct: 125 KFNSTMKVLMLNSNMVGK-IWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLT 183

Query: 157 YKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLD--FWESGEWVIVDA 214
             + C + +  FP D+ +C ++F S+ Y K +I+       V+  D  +W   ++  V  
Sbjct: 184 INAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGL 243

Query: 215 VGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSEC-GE 273
               +T      +  Y  +T  F + R   ++TI   IPC+L   L+ + F++  +    
Sbjct: 244 --RNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPA 301

Query: 274 KITLCISVLLSLTVFLLLITEIIPSTSLVIPL-IGEYLLFTMIFVTL 319
           + +L I+ +L++T    +  + +P  S V  + +   + F  +F  L
Sbjct: 302 RTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAAL 348


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,119,324
Number of Sequences: 37866
Number of extensions: 1647141
Number of successful extensions: 13624
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 148
Number of HSP's successfully gapped in prelim test: 831
Number of HSP's that attempted gapping in prelim test: 9747
Number of HSP's gapped (non-prelim): 3494
length of query: 627
length of database: 18,247,518
effective HSP length: 108
effective length of query: 519
effective length of database: 14,157,990
effective search space: 7347996810
effective search space used: 7347996810
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.