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Search of human proteins with 4502747
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 756 0.0
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 291 8e-79
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 291 8e-79
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 290 1e-78
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 290 1e-78
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 232 5e-61
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 229 4e-60
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 229 4e-60
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 228 9e-60
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 228 9e-60
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 228 9e-60
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 228 9e-60
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 228 9e-60
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 228 9e-60
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 225 4e-59
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 223 2e-58
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 218 5e-57
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 218 7e-57
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 218 7e-57
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 214 8e-56
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 214 1e-55
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 212 4e-55
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 212 5e-55
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 210 1e-54
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 210 1e-54
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 210 1e-54
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 209 4e-54
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 194 1e-49
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens] 192 3e-49
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 192 5e-49
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 756 bits (1951), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
Sbjct: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60
Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
Sbjct: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120
Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
Sbjct: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180
Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240
Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
Sbjct: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300
Query: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP 360
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
Sbjct: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP 360
Query: 361 ATTNQTEFERVF 372
ATTNQTEFERVF
Sbjct: 361 ATTNQTEFERVF 372
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 291 bits (744), Expect = 8e-79
Identities = 160/366 (43%), Positives = 228/366 (62%), Gaps = 20/366 (5%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
V K++ + IG+GT+G+V+KA+ + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 76 ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133
+VVN+ EI K A + + KG+ YLVF++ +HDL GLL + LV F+ IK M+ L
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193
+ GL Y H+ LHRD+K +N+L+ G +KLADFGLAR ++ ++ S+P YTN+V+TLW
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYN-SEESRP--YTNKVITLW 900
Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253
YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS+LCGS P VW
Sbjct: 901 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 960
Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313
P+V + ++ K +R++++ ALDL+D +L LDP++R ++ L D
Sbjct: 961 PDVIKLPYFNTMKPKKQYRRRLREEFSFI--PSAALDLLDHMLTLDPSKRCTAEQTLQSD 1018
Query: 314 FF----WSDPMPSDLKGMLSTHLTSMFEYLAPPRRK----GSQITQQSTNQSRNPATTNQ 365
F S P DL H E + RR+ G + + +++ TT+
Sbjct: 1019 FLKDVELSKMAPPDL-----PHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSG 1073
Query: 366 TEFERV 371
T E V
Sbjct: 1074 TSTEPV 1079
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 291 bits (744), Expect = 8e-79
Identities = 160/366 (43%), Positives = 228/366 (62%), Gaps = 20/366 (5%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
V K++ + IG+GT+G+V+KA+ + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 76 ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133
+VVN+ EI K A + + KG+ YLVF++ +HDL GLL + LV F+ IK M+ L
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193
+ GL Y H+ LHRD+K +N+L+ G +KLADFGLAR ++ ++ S+P YTN+V+TLW
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYN-SEESRP--YTNKVITLW 900
Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253
YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS+LCGS P VW
Sbjct: 901 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 960
Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313
P+V + ++ K +R++++ ALDL+D +L LDP++R ++ L D
Sbjct: 961 PDVIKLPYFNTMKPKKQYRRRLREEFSFI--PSAALDLLDHMLTLDPSKRCTAEQTLQSD 1018
Query: 314 FF----WSDPMPSDLKGMLSTHLTSMFEYLAPPRRK----GSQITQQSTNQSRNPATTNQ 365
F S P DL H E + RR+ G + + +++ TT+
Sbjct: 1019 FLKDVELSKMAPPDL-----PHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSG 1073
Query: 366 TEFERV 371
T E V
Sbjct: 1074 TSTEPV 1079
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 290 bits (742), Expect = 1e-78
Identities = 151/312 (48%), Positives = 214/312 (68%), Gaps = 10/312 (3%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
V K++ + IG+GT+G+V+KAR + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H
Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
Query: 76 ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133
++++N+ EI K A + + KG+ YLVF++ +HDL GLL + LV F + IK M+ L
Sbjct: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193
+ GL Y H+ LHRD+K +N+L+ G +KLADFGLAR +S ++ S+P YTN+V+TLW
Sbjct: 822 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS-SEESRP--YTNKVITLW 878
Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253
YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS++CGS P VW
Sbjct: 879 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 938
Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP-YALDLIDKLLVLDPAQRIDSDDALNH 312
P+V + ++ K +RK+++ +V P ALDL D +L LDP++R ++ AL
Sbjct: 939 PDVIKLPYFNTMKPKKQYRRKLREE---FVFIPAAALDLFDYMLALDPSKRCTAEQALQC 995
Query: 313 DFFWSDPMPSDL 324
+F D PS +
Sbjct: 996 EFL-RDVEPSKM 1006
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 290 bits (742), Expect = 1e-78
Identities = 151/312 (48%), Positives = 214/312 (68%), Gaps = 10/312 (3%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
V K++ + IG+GT+G+V+KAR + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H
Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
Query: 76 ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133
++++N+ EI K A + + KG+ YLVF++ +HDL GLL + LV F + IK M+ L
Sbjct: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193
+ GL Y H+ LHRD+K +N+L+ G +KLADFGLAR +S ++ S+P YTN+V+TLW
Sbjct: 822 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS-SEESRP--YTNKVITLW 878
Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253
YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS++CGS P VW
Sbjct: 879 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 938
Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP-YALDLIDKLLVLDPAQRIDSDDALNH 312
P+V + ++ K +RK+++ +V P ALDL D +L LDP++R ++ AL
Sbjct: 939 PDVIKLPYFNTMKPKKQYRRKLREE---FVFIPAAALDLFDYMLALDPSKRCTAEQALQC 995
Query: 313 DFFWSDPMPSDL 324
+F D PS +
Sbjct: 996 EFL-RDVEPSKM 1006
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 232 bits (591), Expect = 5e-61
Identities = 125/311 (40%), Positives = 182/311 (58%), Gaps = 12/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V ++EKL +IG+GT+G V++AR +T + VALKKV M+ EK+G PI++LREI +L
Sbjct: 33 CRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLR 92
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
L+H N+V L E+ SI+LV +CE DLA LL N+ F+ +++K ++
Sbjct: 93 LRHPNIVELKEVV------VGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQ 146
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
+L GL Y+HRN I+HRD+K +N+L+T G +K ADFGLARA+ + T +VVTL
Sbjct: 147 VLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPM----TPKVVTL 202
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ID+W GCI+AE+ P++ G +E HQ+ LI QL G+ + +
Sbjct: 203 WYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENI 262
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP L + L K +K + L L+ L + DP +R + D L
Sbjct: 263 WPGFSKLPLVGQYSLRKQPYNNLKHKFPWL--SEAGLRLLHFLFMYDPKKRATAGDCLES 320
Query: 313 DFFWSDPMPSD 323
+F P+P +
Sbjct: 321 SYFKEKPLPCE 331
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 229 bits (583), Expect = 4e-60
Identities = 117/311 (37%), Positives = 183/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 407 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 466
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 467 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 520
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVT
Sbjct: 521 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTQ 576
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ GN+E Q+ + + G+ + ++
Sbjct: 577 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKI 636
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP + +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 637 WPGYSELPVVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 695
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 696 EYFRETPLPID 706
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 229 bits (583), Expect = 4e-60
Identities = 117/311 (37%), Positives = 183/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 417 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 476
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 477 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 530
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVT
Sbjct: 531 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTQ 586
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ GN+E Q+ + + G+ + ++
Sbjct: 587 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKI 646
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP + +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 647 WPGYSELPVVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 705
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 706 EYFRETPLPID 716
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 228 bits (580), Expect = 9e-60
Identities = 117/311 (37%), Positives = 182/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 408 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 467
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 468 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 521
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVTL
Sbjct: 522 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTL 577
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ G +E Q+ + + G+ + ++
Sbjct: 578 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 637
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 638 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 696
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 697 EYFRETPLPID 707
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 228 bits (580), Expect = 9e-60
Identities = 117/311 (37%), Positives = 182/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 417 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 476
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 477 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 530
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVTL
Sbjct: 531 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTL 586
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ G +E Q+ + + G+ + ++
Sbjct: 587 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 646
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 647 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 705
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 706 EYFRETPLPID 716
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 228 bits (580), Expect = 9e-60
Identities = 117/311 (37%), Positives = 182/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 385 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 444
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 445 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 498
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVTL
Sbjct: 499 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTL 554
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ G +E Q+ + + G+ + ++
Sbjct: 555 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 614
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 615 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 673
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 674 EYFRETPLPID 684
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 228 bits (580), Expect = 9e-60
Identities = 117/311 (37%), Positives = 182/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 374 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 433
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 434 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 487
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVTL
Sbjct: 488 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTL 543
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ G +E Q+ + + G+ + ++
Sbjct: 544 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 603
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 604 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 662
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 663 EYFRETPLPID 673
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 228 bits (580), Expect = 9e-60
Identities = 117/311 (37%), Positives = 182/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 163 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 222
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 223 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 276
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVTL
Sbjct: 277 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTL 332
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ G +E Q+ + + G+ + ++
Sbjct: 333 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 392
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 393 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 451
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 452 EYFRETPLPID 462
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 228 bits (580), Expect = 9e-60
Identities = 117/311 (37%), Positives = 182/311 (58%), Gaps = 11/311 (3%)
Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72
C V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI +
Sbjct: 419 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 478
Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132
+H N+V + EI IY+V ++ EHDL L+ + F E+K +M
Sbjct: 479 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 532
Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192
LL G+ ++H N ILHRD+K +N+L++ G+LK+ DFGLAR + S YT VVTL
Sbjct: 533 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTL 588
Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252
WYR PELLLG ++Y +D+W GCI E+ T+ P+ G +E Q+ + + G+ + ++
Sbjct: 589 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 648
Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
WP +K+ + ++ R A + D DL++K L P +RI ++D L H
Sbjct: 649 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 707
Query: 313 DFFWSDPMPSD 323
++F P+P D
Sbjct: 708 EYFRETPLPID 718
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 225 bits (574), Expect = 4e-59
Identities = 124/300 (41%), Positives = 181/300 (60%), Gaps = 19/300 (6%)
Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78
Y K+ KIG+GT+G V+K RH+ TGQ VA+KK+ +E+E+EG P TA+REI +L+ L+H N+
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63
Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQMLLNG 136
V+L ++ + +YL+F+F DL L ++ S +K + +L G
Sbjct: 64 VSLQDVLMQDS--------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115
Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYR 195
+ + H ++LHRD+K N+LI G +KLADFGLARAF + P R YT+ VVTLWYR
Sbjct: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-----PIRVYTHEVVTLWYR 170
Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255
PE+LLG Y P+D+W G I AE+ T+ P+ G++E QL I + G+ EVWP
Sbjct: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230
Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
V++ + Y K K + + +K D LDL+ K+L+ DPA+RI ALNH +F
Sbjct: 231 VESLQDY-KNTFPKWKPGSLASHVKNL--DENGLDLLSKMLIYDPAKRISGKMALNHPYF 287
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 223 bits (569), Expect = 2e-58
Identities = 122/300 (40%), Positives = 180/300 (60%), Gaps = 19/300 (6%)
Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78
Y K+ KIG+GT+G V+K RH+ TGQ VA+KK+ +E+E+EG P TA+REI +L+ L+H N+
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63
Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQMLLNG 136
V+L ++ + +YL+F+F DL L ++ S +K + +L G
Sbjct: 64 VSLQDVLMQDS--------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115
Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYR 195
+ + H ++LHRD+K N+LI G +KLADFGLARAF + P R YT+ +TLWYR
Sbjct: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-----PIRVYTHEAITLWYR 170
Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255
PE+LLG Y P+D+W G I AE+ T+ P+ G++E QL I + G+ EVWP
Sbjct: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230
Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
V++ + Y K K + + +K D LDL+ K+L+ DPA+RI ALNH +F
Sbjct: 231 VESLQDY-KNTFPKWKPGSLASHVKNL--DENGLDLLSKMLIYDPAKRISGKMALNHPYF 287
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 218 bits (556), Expect = 5e-57
Identities = 124/305 (40%), Positives = 185/305 (60%), Gaps = 17/305 (5%)
Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78
++K+ KIG+GT+G V+KA++R+TGQ VALKK+ ++ E EG P TA+REI +L+ LKH N+
Sbjct: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNI 63
Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRVMQMLLNGL 137
V L+++ + +YLVF+F DL + S + L IK + LL G+
Sbjct: 64 VRLLDVVHNER--------KLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGV 115
Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197
+ H ++++HRD+K N+LI G +KLADFGLARAF + + YT+ VVTLWYR P
Sbjct: 116 SFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRT----YTHEVVTLWYRAP 171
Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257
E+LLG + Y +D+W GCI AEM TR + G++E QL I ++ G+ + + WP V
Sbjct: 172 EILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVT 231
Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317
Y K K ++ +++ + +P DL+ +LL DP+QRI + AL H +F S
Sbjct: 232 QLPDY-KGSFPKWTRKGLEEIVPNL--EPEGRDLLMQLLQYDPSQRITAKTALAHPYF-S 287
Query: 318 DPMPS 322
P PS
Sbjct: 288 SPEPS 292
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 218 bits (555), Expect = 7e-57
Identities = 123/303 (40%), Positives = 176/303 (58%), Gaps = 15/303 (4%)
Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74
++ Y KL K+G+GT+ V+K + + T VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 167 KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLK 225
Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
H N+V L +I T+ S + LVF++ + DL L + + +K + LL
Sbjct: 226 HANIVTLHDIIHTEKS--------LTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 277
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
GL Y HR K+LHRD+K N+LI G LKLADFGLARA S+ + Y+N VVTLWY
Sbjct: 278 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKT----YSNEVVTLWY 333
Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
RPP++LLG DY ID+WG GCI EM T P+ G+T + QL I ++ G+ T E WP
Sbjct: 334 RPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP 393
Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
+ + E ++ K + + A D DL+ KLL + RI ++DA+ H F
Sbjct: 394 GILSNEEFKTYNYPKYRAEALLSH--APRLDSDGADLLTKLLQFEGRNRISAEDAMKHPF 451
Query: 315 FWS 317
F S
Sbjct: 452 FLS 454
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 218 bits (555), Expect = 7e-57
Identities = 123/303 (40%), Positives = 176/303 (58%), Gaps = 15/303 (4%)
Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74
++ Y KL K+G+GT+ V+K + + T VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 161 KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLK 219
Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
H N+V L +I T+ S + LVF++ + DL L + + +K + LL
Sbjct: 220 HANIVTLHDIIHTEKS--------LTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 271
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
GL Y HR K+LHRD+K N+LI G LKLADFGLARA S+ + Y+N VVTLWY
Sbjct: 272 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKT----YSNEVVTLWY 327
Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
RPP++LLG DY ID+WG GCI EM T P+ G+T + QL I ++ G+ T E WP
Sbjct: 328 RPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP 387
Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
+ + E ++ K + + A D DL+ KLL + RI ++DA+ H F
Sbjct: 388 GILSNEEFKTYNYPKYRAEALLSH--APRLDSDGADLLTKLLQFEGRNRISAEDAMKHPF 445
Query: 315 FWS 317
F S
Sbjct: 446 FLS 448
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 214 bits (546), Expect = 8e-56
Identities = 122/309 (39%), Positives = 177/309 (57%), Gaps = 16/309 (5%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
+ +Y L +IG+G G VFKA+H +TG+ VALKKV + ++GFP ALREIK LQ ++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135
V ++ P+ G L F+F DLA ++ + +++K +QMLL
Sbjct: 61 NQYVVQLKA----VFPHG---GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLK 113
Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195
G+ + H N I+HRD+K AN+LI+ G LK+ADFGLAR FS YT++V T WYR
Sbjct: 114 GVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFS---PDGSRLYTHQVATRWYR 170
Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255
PELL G R Y +DLW GCIM E+ SP+ G + QL + ++ G+ P+VWP
Sbjct: 171 APELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 230
Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRD--PYALDLIDKLLVLDPAQRIDSDDALNHD 313
+ Y K+ K +V L+ + D P ALDL+ + L+ P QRI + AL H
Sbjct: 231 LTELPDYNKISF----KEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQ 286
Query: 314 FFWSDPMPS 322
+F++ P+P+
Sbjct: 287 YFFTAPLPA 295
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 214 bits (545), Expect = 1e-55
Identities = 123/303 (40%), Positives = 175/303 (57%), Gaps = 20/303 (6%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
+ KYEKL KIG+GT+G VFKA++R+T + VALK+V ++++ EG P +ALREI +L+ LKH
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135
+N+V L ++ + + LVF+FC+ DL + +K + LL
Sbjct: 61 KNIVRLHDVLHSDK--------KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLK 112
Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195
GL + H +LHRD+K N+LI R+G LKLADFGLARAF + Y+ VVTLWYR
Sbjct: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC----YSAEVVTLWYR 168
Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPEVWP 254
PP++L G + Y ID+W AGCI AE+ P+ GN QL I +L G+ T E WP
Sbjct: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228
Query: 255 NVDNYELYEKLELVKGQKR--KVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312
++ Y+ + V +L A R DL+ LL +P QRI +++AL H
Sbjct: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGR-----DLLQNLLKCNPVQRISAEEALQH 283
Query: 313 DFF 315
+F
Sbjct: 284 PYF 286
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 212 bits (540), Expect = 4e-55
Identities = 120/301 (39%), Positives = 176/301 (58%), Gaps = 16/301 (5%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
+ ++K+ KIG+GT+G V+KAR++ TG+ VALKK+ ++ E EG P TA+REI +L+ L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRVMQMLL 134
N+V L+++ T + +YLVF+F DL + ++ L L IK + LL
Sbjct: 61 PNIVKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
GL + H +++LHRD+K N+LI +G +KLADFGLARAF + + YT+ VVTLWY
Sbjct: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----YTHEVVTLWY 168
Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
R PE+LLG + Y +D+W GCI AEM TR + G++E QL I + G+ VWP
Sbjct: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228
Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
V + Y K K ++ + D L+ ++L DP +RI + AL H F
Sbjct: 229 GVTSMPDY-KPSFPKWARQDFSKVVPPLDED--GRSLLSQMLHYDPNKRISAKAALAHPF 285
Query: 315 F 315
F
Sbjct: 286 F 286
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 212 bits (539), Expect = 5e-55
Identities = 116/303 (38%), Positives = 180/303 (59%), Gaps = 15/303 (4%)
Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74
++ Y KL K+G+GT+ V+K R + T VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 188 KMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLK 246
Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
H N+V L +I T S + LVF++ + DL + + ++ +K + +L
Sbjct: 247 HANIVTLHDIVHTDKS--------LTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQIL 298
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
GL Y HR K+LHRD+K N+LI G LKLADFGLARA S+ + Y+N VVTLWY
Sbjct: 299 RGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKT----YSNEVVTLWY 354
Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
RPP++LLG +Y ID+WG GCI EM + P+ G+T + +L LI +L G+ + E WP
Sbjct: 355 RPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWP 414
Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
+ + E ++ K + + + + A D ++LI K L + +R+ +++A+ H +
Sbjct: 415 GISSNEEFKNYNFPKYKPQPLINH--APRLDSEGIELITKFLQYESKKRVSAEEAMKHVY 472
Query: 315 FWS 317
F S
Sbjct: 473 FRS 475
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 210 bits (535), Expect = 1e-54
Identities = 121/303 (39%), Positives = 175/303 (57%), Gaps = 15/303 (4%)
Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74
++ Y KL K+G+GT+ VFK R + T VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 170 KLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLK 228
Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
H N+V L ++ T S + LVF++ + DL L + ++ +K M LL
Sbjct: 229 HANIVTLHDLIHTDRS--------LTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLL 280
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
GL Y H KILHRD+K N+LI G LKLADFGLARA S+ + Y+N VVTLWY
Sbjct: 281 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKT----YSNEVVTLWY 336
Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
RPP++LLG +Y PID+WG GCI EM T P+ G+T + +L LI +L G+ T E WP
Sbjct: 337 RPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWP 396
Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
V + + + + + A D + L+ LL+ + R+ ++ AL+H +
Sbjct: 397 GVTAFSEFRTYSFPCYLPQPLINH--APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSY 454
Query: 315 FWS 317
F S
Sbjct: 455 FRS 457
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 210 bits (535), Expect = 1e-54
Identities = 121/303 (39%), Positives = 175/303 (57%), Gaps = 15/303 (4%)
Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74
++ Y KL K+G+GT+ VFK R + T VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 140 KLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLK 198
Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
H N+V L ++ T S + LVF++ + DL L + ++ +K M LL
Sbjct: 199 HANIVTLHDLIHTDRS--------LTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLL 250
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
GL Y H KILHRD+K N+LI G LKLADFGLARA S+ + Y+N VVTLWY
Sbjct: 251 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKT----YSNEVVTLWY 306
Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
RPP++LLG +Y PID+WG GCI EM T P+ G+T + +L LI +L G+ T E WP
Sbjct: 307 RPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWP 366
Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
V + + + + + A D + L+ LL+ + R+ ++ AL+H +
Sbjct: 367 GVTAFSEFRTYSFPCYLPQPLINH--APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSY 424
Query: 315 FWS 317
F S
Sbjct: 425 FRS 427
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 210 bits (535), Expect = 1e-54
Identities = 121/303 (39%), Positives = 175/303 (57%), Gaps = 15/303 (4%)
Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74
++ Y KL K+G+GT+ VFK R + T VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 140 KLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLK 198
Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
H N+V L ++ T S + LVF++ + DL L + ++ +K M LL
Sbjct: 199 HANIVTLHDLIHTDRS--------LTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLL 250
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
GL Y H KILHRD+K N+LI G LKLADFGLARA S+ + Y+N VVTLWY
Sbjct: 251 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKT----YSNEVVTLWY 306
Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
RPP++LLG +Y PID+WG GCI EM T P+ G+T + +L LI +L G+ T E WP
Sbjct: 307 RPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWP 366
Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
V + + + + + A D + L+ LL+ + R+ ++ AL+H +
Sbjct: 367 GVTAFSEFRTYSFPCYLPQPLINH--APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSY 424
Query: 315 FWS 317
F S
Sbjct: 425 FRS 427
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 209 bits (531), Expect = 4e-54
Identities = 127/309 (41%), Positives = 180/309 (58%), Gaps = 21/309 (6%)
Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE---KEGFPITALREIKILQLLK 74
+YEKL +G+G F V+KAR + T Q VA+KK+ + + K+G TALREIK+LQ L
Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70
Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
H N++ L++ K++ I LVFDF E DL ++ + + T S IK M M L
Sbjct: 71 HPNIIGLLDAFGHKSN--------ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122
Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLW 193
GL Y+H++ ILHRD+K N+L+ +GVLKLADFGLA++F PNR YT++VVT W
Sbjct: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-----GSPNRAYTHQVVTRW 177
Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253
YR PELL G R YG +D+W GCI+AE+ R P + G+++ QL I + G+ T E W
Sbjct: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237
Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313
P++ + Y + G + A D LDLI L + +P RI + AL
Sbjct: 238 PDMCSLPDYVTFKSFPG--IPLHHIFSAAGDD--LLDLIQGLFLFNPCARITATQALKMK 293
Query: 314 FFWSDPMPS 322
+F + P P+
Sbjct: 294 YFSNRPGPT 302
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 194 bits (492), Expect = 1e-49
Identities = 105/300 (35%), Positives = 166/300 (55%), Gaps = 13/300 (4%)
Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
+ KYEK+ KIG+G++G VFK R+R TGQ VA+KK L + ALREI++L+ LKH
Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61
Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135
N+VNL+E+ R K ++LVF++C+H + L +K + L
Sbjct: 62 PNLVNLLEVFRRKR--------RLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQ 113
Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195
+ + H++ +HRD+K N+LIT+ V+KL DFG AR + + YT+ V T WYR
Sbjct: 114 AVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT----GPSDYYTDYVATRWYR 169
Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255
PELL+G+ YGPP+D+W GC+ AE+ + P+ G ++ QL LI + G + P
Sbjct: 170 SPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQV 229
Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
+ + +++ + + + + P AL L+ L +DP QR+ + L+H +F
Sbjct: 230 FSTNQYFSGVKIPDPEDMEPLELKFPNISYP-ALGLLKGCLHMDPTQRLTCEQLLHHPYF 288
>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
Length = 289
Score = 192 bits (489), Expect = 3e-49
Identities = 105/272 (38%), Positives = 153/272 (56%), Gaps = 12/272 (4%)
Query: 52 MENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLA 111
M+ EK+G PI++LREI +L L+H N+V L E+ SI+LV +CE DLA
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVV------VGNHLESIFLVMGYCEQDLA 54
Query: 112 GLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA 171
LL N+ F+ +++K ++ +L GL Y+HRN I+HRD+K +N+L+T G +K ADFGLA
Sbjct: 55 SLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLA 114
Query: 172 RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231
RA+ + T +VVTLWYR PELLLG ID+W GCI+AE+ P++ G
Sbjct: 115 RAYGVPVKPM----TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPG 170
Query: 232 NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291
+E HQ+ LI QL G+ + +WP L + L K +K + L L
Sbjct: 171 TSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWL--SEAGLRL 228
Query: 292 IDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323
+ L + DP +R + D L +F P+P +
Sbjct: 229 LHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 260
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 192 bits (487), Expect = 5e-49
Identities = 120/309 (38%), Positives = 165/309 (53%), Gaps = 16/309 (5%)
Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76
S Y L K+G+G++ V+K R GQ VALK + M N +EG P TA+RE +L+ LKH
Sbjct: 50 SSYLNLEKLGEGSYATVYKGISRINGQLVALKVISM-NAEEGVPFTAIREASLLKGLKHA 108
Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136
N+V L +I TK + + VF++ DLA +S ++ M LL G
Sbjct: 109 NIVLLHDIIHTKET--------LTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRG 160
Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196
L YIH +LHRD+K N+LI+ G LKLADFGLARA S+ + Y++ VVTLWYRP
Sbjct: 161 LAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQT----YSSEVVTLWYRP 216
Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG-NTEQHQLALISQLCGSITPEVWPN 255
P+ LLG +Y +D+WGAGCI EM+ P+ G + QL I ++ G T + WP
Sbjct: 217 PDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPG 276
Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
V Y R + R P A DL ++L P R+ + +AL HD+F
Sbjct: 277 VSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
Query: 316 WSDPMPSDL 324
+PS L
Sbjct: 337 --SALPSQL 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,928,982
Number of Sequences: 37866
Number of extensions: 606150
Number of successful extensions: 3623
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 723
Number of HSP's successfully gapped in prelim test: 68
Number of HSP's that attempted gapping in prelim test: 1354
Number of HSP's gapped (non-prelim): 1048
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.