Guide to the Human Genome
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Search of human proteins with 4502581

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
         (303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15718698 caspase 7 isoform delta [Homo sapiens]                    627   e-180
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                    627   e-180
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]           627   e-180
gi|15718702 caspase 7 isoform beta [Homo sapiens]                     306   2e-83
gi|14790115 caspase 3 preproprotein [Homo sapiens]                    282   3e-76
gi|14790119 caspase 3 preproprotein [Homo sapiens]                    282   3e-76
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]      184   8e-47
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]         168   5e-42
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]         167   1e-41
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]             161   8e-40
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             161   8e-40
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              161   8e-40
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              161   8e-40
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              161   8e-40
gi|14916485 caspase 6 isoform beta [Homo sapiens]                     154   9e-38
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]         150   1e-36
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]      134   1e-31
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]          125   6e-29
gi|6912286 caspase 14 precursor [Homo sapiens]                        100   3e-21
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]              75   9e-14
gi|209870073 caspase 5 isoform c [Homo sapiens]                        75   9e-14
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]              75   9e-14
gi|209870069 caspase 5 isoform a precursor [Homo sapiens]              75   9e-14
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]           69   4e-12
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]           69   4e-12
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]             69   4e-12
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]           67   3e-11
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]            67   3e-11
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap...    65   7e-11
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap...    65   7e-11

>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score =  627 bits (1616), Expect = e-180
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
           MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 34  MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 93

Query: 61  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
           NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 94  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 153

Query: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
           DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
Sbjct: 154 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 213

Query: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
           FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
Sbjct: 214 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 273

Query: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
           FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
Sbjct: 274 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 333

Query: 301 FSQ 303
           FSQ
Sbjct: 334 FSQ 336


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score =  627 bits (1616), Expect = e-180
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
           MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 1   MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60

Query: 61  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
           NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 61  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120

Query: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
           DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
Sbjct: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180

Query: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
           FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
Sbjct: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240

Query: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
           FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300

Query: 301 FSQ 303
           FSQ
Sbjct: 301 FSQ 303


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score =  627 bits (1616), Expect = e-180
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
           MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 1   MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60

Query: 61  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
           NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 61  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120

Query: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
           DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
Sbjct: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180

Query: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
           FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
Sbjct: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240

Query: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
           FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300

Query: 301 FSQ 303
           FSQ
Sbjct: 301 FSQ 303


>gi|15718702 caspase 7 isoform beta [Homo sapiens]
          Length = 253

 Score =  306 bits (783), Expect = 2e-83
 Identities = 148/149 (99%), Positives = 149/149 (100%)

Query: 1   MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
           MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 1   MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60

Query: 61  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
           NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 61  NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120

Query: 121 DLLKKASEEDHTNAACFACILLSHGEENV 149
           DLLKKASEEDHTNAACFACILLSHGEEN+
Sbjct: 121 DLLKKASEEDHTNAACFACILLSHGEENM 149


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  282 bits (721), Expect = 3e-76
 Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)

Query: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
           Y M++ ++G CIIINNKNF K TGM  R+GTD DA  L + FR+L ++V   ND +  ++
Sbjct: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96

Query: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179
            +L++  S+EDH+  + F C+LLSHGEE +I+G +G   +K +T  FRGDRC++L  KPK
Sbjct: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156

Query: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239
           LF IQACRGTELD GI+ DSG  +D      +KIPVEADFL+AYST PGYYSWR+   GS
Sbjct: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213

Query: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299
           WF+Q+LC++L+++   LE M ILTRVN +VA  FES S D  FH KKQIPC+VSMLTKEL
Sbjct: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273

Query: 300 YF 301
           YF
Sbjct: 274 YF 275


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  282 bits (721), Expect = 3e-76
 Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)

Query: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
           Y M++ ++G CIIINNKNF K TGM  R+GTD DA  L + FR+L ++V   ND +  ++
Sbjct: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96

Query: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179
            +L++  S+EDH+  + F C+LLSHGEE +I+G +G   +K +T  FRGDRC++L  KPK
Sbjct: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156

Query: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239
           LF IQACRGTELD GI+ DSG  +D      +KIPVEADFL+AYST PGYYSWR+   GS
Sbjct: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213

Query: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299
           WF+Q+LC++L+++   LE M ILTRVN +VA  FES S D  FH KKQIPC+VSMLTKEL
Sbjct: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273

Query: 300 YF 301
           YF
Sbjct: 274 YF 275


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score =  184 bits (467), Expect = 8e-47
 Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)

Query: 56  PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115
           P  +Y M+  + G  +I N++ F     +  R GT  D + L + F  LGF+V  +ND  
Sbjct: 33  PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92

Query: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 175
             ++   + + S   H +A CF C+ LSHGE N IY  D    I+ LT  F+GD+C +L+
Sbjct: 93  AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152

Query: 176 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 225
            KPK+F IQACRG +          +D+  +     I + DA   Y +P  ADFL  YS 
Sbjct: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212

Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
             GYYS R    GSW++Q LC +L ++G  LE  ++LT VN +V++       DP    K
Sbjct: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272

Query: 286 KQIPCVVSMLTKELYF 301
           KQ+PC  SMLTK+L+F
Sbjct: 273 KQVPCFASMLTKKLHF 288


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score =  168 bits (426), Expect = 5e-42
 Identities = 99/274 (36%), Positives = 151/274 (55%), Gaps = 14/274 (5%)

Query: 33  PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 92
           PSL S+  +  +  ++ +         Y MN    G C+I+NN +F   T +  R GT K
Sbjct: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305

Query: 93  DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIY 151
           DAE L   F+ LGF V ++N+ +  +M+ +L+K      H +  CF   +L+HG    +Y
Sbjct: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365

Query: 152 GKD-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--N 208
             D  + PI+++ +HF   +C  L EKPKLFFIQAC+G E+   +  ++  +N   A  +
Sbjct: 366 SSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS 425

Query: 209 PRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVND 267
            +  IP EADFL   +TVPGY S+R    GSW++Q+LC+ L++   +  +I+ ILT VND
Sbjct: 426 LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVND 485

Query: 268 RVARHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
            V+R  + Q        KKQ+P     L K+L F
Sbjct: 486 DVSRRVDKQG------TKKQMPQPAFTLRKKLVF 513


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score =  167 bits (422), Expect = 1e-41
 Identities = 99/272 (36%), Positives = 153/272 (56%), Gaps = 15/272 (5%)

Query: 36  FSKKKKNVTMRSIKTTRDRVPTYQ-YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDA 94
           +  +++ V+   +KT  + +P    Y MN    G C+I+NN +F   T +  R GT KDA
Sbjct: 208 YQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDA 264

Query: 95  EALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIYGK 153
           E L   F+ LGF V ++N+ +  +M+ +L+K      H +  CF   +L+HG    +Y  
Sbjct: 265 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 324

Query: 154 D-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--NPR 210
           D  + PI+++ +HF   +C  L EKPKLFFIQAC+G E+   +  ++  +N   A  + +
Sbjct: 325 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ 384

Query: 211 YKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVNDRV 269
             IP EADFL   +TVPGY S+R    GSW++Q+LC+ L++   +  +I+ ILT VND V
Sbjct: 385 DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDV 444

Query: 270 ARHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
           +R  + Q        KKQ+P     L K+L F
Sbjct: 445 SRRVDKQG------TKKQMPQPAFTLRKKLVF 470


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score =  161 bits (407), Expect = 8e-40
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344

Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 345 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 404

Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 405 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 464

Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 465 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 518

Query: 285 KKQIPCVVSMLTKELYF 301
            KQ+P     L K+L F
Sbjct: 519 GKQMPQPTFTLRKKLVF 535


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  161 bits (407), Expect = 8e-40
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270

Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330

Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390

Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444

Query: 285 KKQIPCVVSMLTKELYF 301
            KQ+P     L K+L F
Sbjct: 445 GKQMPQPTFTLRKKLVF 461


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  161 bits (407), Expect = 8e-40
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270

Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330

Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390

Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444

Query: 285 KKQIPCVVSMLTKELYF 301
            KQ+P     L K+L F
Sbjct: 445 GKQMPQPTFTLRKKLVF 461


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  161 bits (407), Expect = 8e-40
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285

Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 286 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 345

Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 346 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 405

Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 406 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 459

Query: 285 KKQIPCVVSMLTKELYF 301
            KQ+P     L K+L F
Sbjct: 460 GKQMPQPTFTLRKKLVF 476


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  161 bits (407), Expect = 8e-40
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302

Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 303 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 362

Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 363 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 422

Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 423 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 476

Query: 285 KKQIPCVVSMLTKELYF 301
            KQ+P     L K+L F
Sbjct: 477 GKQMPQPTFTLRKKLVF 493


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score =  154 bits (389), Expect = 9e-38
 Identities = 79/185 (42%), Positives = 106/185 (57%), Gaps = 10/185 (5%)

Query: 127 SEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQAC 186
           S   H +A CF C+ LSHGE N IY  D    I+ LT  F+GD+C +L+ KPK+F IQAC
Sbjct: 15  STVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAC 74

Query: 187 RGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPG 236
           RG +          +D+  +     I + DA   Y +P  ADFL  YS   GYYS R   
Sbjct: 75  RGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETV 134

Query: 237 RGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLT 296
            GSW++Q LC +L ++G  LE  ++LT VN +V++       DP    KKQ+PC  SMLT
Sbjct: 135 NGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLT 194

Query: 297 KELYF 301
           K+L+F
Sbjct: 195 KKLHF 199


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score =  150 bits (380), Expect = 1e-36
 Identities = 81/223 (36%), Positives = 126/223 (56%), Gaps = 7/223 (3%)

Query: 33  PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 92
           PSL S+  +  +  ++ +         Y MN    G C+I+NN +F   T +  R GT K
Sbjct: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305

Query: 93  DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIY 151
           DAE L   F+ LGF V ++N+ +  +M+ +L+K      H +  CF   +L+HG    +Y
Sbjct: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365

Query: 152 GKD-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--N 208
             D  + PI+++ +HF   +C  L EKPKLFFIQAC+G E+   +  ++  +N   A  +
Sbjct: 366 SSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS 425

Query: 209 PRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE 251
            +  IP EADFL   +TVPGY S+R    GSW++Q+LC+ L++
Sbjct: 426 LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score =  134 bits (337), Expect = 1e-31
 Identities = 88/271 (32%), Positives = 130/271 (47%), Gaps = 39/271 (14%)

Query: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
           Y ++ E  G C+IINN NF + +G+  R G++ D E L + F SL F V V  D +  KM
Sbjct: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212

Query: 120 QDLLKKASEEDHTNAACFACILLSHGEE-------NVIYGKDGV-TPIKDLTAHFRGDRC 171
              L + +++DH    C   ++LSHG +         +YG DG    ++ +   F G  C
Sbjct: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272

Query: 172 KTLLEKPKLFFIQACRGTELDDGIQADS--------GPINDTDANPRYK----------- 212
            +L  KPKLFFIQAC G + D G +  S        G   + DA P  +           
Sbjct: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAI 332

Query: 213 --IPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVA 270
             +P  +D   +YST PG+ SWR P  GSW+V+ L  I E+     ++  +L RV + V+
Sbjct: 333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS 392

Query: 271 RHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
                          KQ+P   + L K+L+F
Sbjct: 393 VK----------GIYKQMPGCFNFLRKKLFF 413


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score =  125 bits (313), Expect = 6e-29
 Identities = 77/255 (30%), Positives = 128/255 (50%), Gaps = 16/255 (6%)

Query: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
           Y +     G  ++++N +F     +  R+G D D   L   F+ LG+DV V  D +  +M
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251

Query: 120 QDLLKKASEEDHTNAACFACI--LLSHGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLE 176
           Q+ L+  ++    +    +CI  LLSHG E  IYG DG +  ++++   F    C +L  
Sbjct: 252 QEKLQNFAQLP-AHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310

Query: 177 KPKLFFIQACRGTELDDGIQADSGP-------INDTDAN----PRYKIPVEADFLFAYST 225
           KPK+FFIQACRG E D G+    G          ++DA     P+ ++P  +D +  Y+ 
Sbjct: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370

Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
           + G  + R+  RGSW+++AL  +  E   D+ +  +L +VN  + +  E  +    FH  
Sbjct: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVN-ALIKDREGYAPGTEFHRC 429

Query: 286 KQIPCVVSMLTKELY 300
           K++    S L + LY
Sbjct: 430 KEMSEYCSTLCRHLY 444


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 67/218 (30%), Positives = 106/218 (48%), Gaps = 10/218 (4%)

Query: 87  RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK---ASEEDHTNAACFACILLS 143
           R G+++D +AL   FR L F+  +  D +  + Q+ L+K   A +      +C   +L++
Sbjct: 29  REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88

Query: 144 HGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
           HG E  + G+DG +  +++L        C+ L  KPK++ IQACRG + D G       I
Sbjct: 89  HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEI 148

Query: 203 NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQIL 262
                +    IP   D L  YSTV GY ++R   +GS F+Q L  +  +  +   I+++L
Sbjct: 149 VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILELL 206

Query: 263 TRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
           T V  R+A     Q        +K  P + S L K LY
Sbjct: 207 TEVTRRMAEAELVQEG----KARKTNPEIQSTLRKRLY 240


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)

Query: 22  VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
           ++A P  S+   ++     +   +R  K   D +  Y      ++    +II N  FD +
Sbjct: 162 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 219

Query: 82  TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
                RNG   D   + +  + LG+ V+   + +   M+ +L+  A+  +H ++     +
Sbjct: 220 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 276

Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
           L+SHG    I G      K  V     +   F    C +L +KPK+  +QACRG +  + 
Sbjct: 277 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 336

Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
              DS             + +A+   KI  E DF+   S+ P   SWR   RGS F+  L
Sbjct: 337 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396

Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
            +  +++     +M+I  +V     + FE          K Q+P +  + LT++ Y
Sbjct: 397 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 442


>gi|209870073 caspase 5 isoform c [Homo sapiens]
          Length = 292

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)

Query: 22  VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
           ++A P  S+   ++     +   +R  K   D +  Y      ++    +II N  FD +
Sbjct: 7   IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 64

Query: 82  TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
                RNG   D   + +  + LG+ V+   + +   M+ +L+  A+  +H ++     +
Sbjct: 65  PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 121

Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
           L+SHG    I G      K  V     +   F    C +L +KPK+  +QACRG +  + 
Sbjct: 122 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 181

Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
              DS             + +A+   KI  E DF+   S+ P   SWR   RGS F+  L
Sbjct: 182 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 241

Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
            +  +++     +M+I  +V     + FE          K Q+P +  + LT++ Y
Sbjct: 242 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 287


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)

Query: 22  VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
           ++A P  S+   ++     +   +R  K   D +  Y      ++    +II N  FD +
Sbjct: 91  IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 148

Query: 82  TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
                RNG   D   + +  + LG+ V+   + +   M+ +L+  A+  +H ++     +
Sbjct: 149 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 205

Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
           L+SHG    I G      K  V     +   F    C +L +KPK+  +QACRG +  + 
Sbjct: 206 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 265

Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
              DS             + +A+   KI  E DF+   S+ P   SWR   RGS F+  L
Sbjct: 266 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325

Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
            +  +++     +M+I  +V     + FE          K Q+P +  + LT++ Y
Sbjct: 326 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 371


>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
          Length = 434

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)

Query: 22  VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
           ++A P  S+   ++     +   +R  K   D +  Y      ++    +II N  FD +
Sbjct: 149 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 206

Query: 82  TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
                RNG   D   + +  + LG+ V+   + +   M+ +L+  A+  +H ++     +
Sbjct: 207 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 263

Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
           L+SHG    I G      K  V     +   F    C +L +KPK+  +QACRG +  + 
Sbjct: 264 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 323

Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
              DS             + +A+   KI  E DF+   S+ P   SWR   RGS F+  L
Sbjct: 324 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383

Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
            +  +++     +M+I  +V     + FE          K Q+P +  + LT++ Y
Sbjct: 384 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 429


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)

Query: 71  IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
           +II N+ FD +     R G + D   +    ++LG+ V V  + + + M   L+  A   
Sbjct: 73  LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 129

Query: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
           +H  +     + +SHG    I GK   + V  I  L A F       C +L +KPK+  I
Sbjct: 130 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 189

Query: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
           QACRG         DS  ++   + P           K  +E DF+   S+ P   SWR 
Sbjct: 190 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 249

Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
           P  GS F+  L   ++E+    ++ +I  +V
Sbjct: 250 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 280


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)

Query: 71  IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
           +II N+ FD +     R G + D   +    ++LG+ V V  + + + M   L+  A   
Sbjct: 166 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 222

Query: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
           +H  +     + +SHG    I GK   + V  I  L A F       C +L +KPK+  I
Sbjct: 223 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 282

Query: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
           QACRG         DS  ++   + P           K  +E DF+   S+ P   SWR 
Sbjct: 283 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 342

Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
           P  GS F+  L   ++E+    ++ +I  +V
Sbjct: 343 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 373


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)

Query: 71  IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
           +II N+ FD +     R G + D   +    ++LG+ V V  + + + M   L+  A   
Sbjct: 145 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 201

Query: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
           +H  +     + +SHG    I GK   + V  I  L A F       C +L +KPK+  I
Sbjct: 202 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 261

Query: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
           QACRG         DS  ++   + P           K  +E DF+   S+ P   SWR 
Sbjct: 262 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 321

Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
           P  GS F+  L   ++E+    ++ +I  +V
Sbjct: 322 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 352


>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
          Length = 321

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)

Query: 71  IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
           +II N  FD +     RNG D D   + +    L + V V  + +   M+  L+  A+  
Sbjct: 83  LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139

Query: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183
           +H ++     +L+SHG    I G      K  V     +   F    C +L +KPK+  +
Sbjct: 140 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 199

Query: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234
           QACRG    +         ++ A S    + + +  YK  VE DF+   S+ P   SWR 
Sbjct: 200 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 259

Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
              GS F+  L +  +++     + ++  +V
Sbjct: 260 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 290


>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
          Length = 377

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)

Query: 71  IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
           +II N  FD +     RNG D D   + +    L + V V  + +   M+  L+  A+  
Sbjct: 139 LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195

Query: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183
           +H ++     +L+SHG    I G      K  V     +   F    C +L +KPK+  +
Sbjct: 196 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 255

Query: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234
           QACRG    +         ++ A S    + + +  YK  VE DF+   S+ P   SWR 
Sbjct: 256 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 315

Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
              GS F+  L +  +++     + ++  +V
Sbjct: 316 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 346


>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 60/213 (28%), Positives = 91/213 (42%), Gaps = 34/213 (15%)

Query: 87  RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHT---NAACFACILLS 143
           R G   D EAL     +LGF+  V  D +    Q+ L +  E+  T     +C    L++
Sbjct: 192 RPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMA 251

Query: 144 HG-EENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
           HG     + G DG   ++         RC+ L  +PK+F +QACRG   D G+   + P 
Sbjct: 252 HGGPRGQLLGADG-QEVQPEALMQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPW 310

Query: 203 NDTDANPRYKIPV-------------------------EADFLFAYSTVPGYYSWRSPGR 237
             +       +P                          +AD L  YS   GY ++R   +
Sbjct: 311 YWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRD-DK 369

Query: 238 GSWFVQALCSILEEH-GKDLEIMQILTRVNDRV 269
           GS F+Q L  +L  + G+DL  +++LT VN RV
Sbjct: 370 GSDFIQTLVEVLRANPGRDL--LELLTEVNRRV 400


>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 60/213 (28%), Positives = 91/213 (42%), Gaps = 34/213 (15%)

Query: 87  RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHT---NAACFACILLS 143
           R G   D EAL     +LGF+  V  D +    Q+ L +  E+  T     +C    L++
Sbjct: 192 RPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMA 251

Query: 144 HG-EENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
           HG     + G DG   ++         RC+ L  +PK+F +QACRG   D G+   + P 
Sbjct: 252 HGGPRGQLLGADG-QEVQPEALMQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPW 310

Query: 203 NDTDANPRYKIPV-------------------------EADFLFAYSTVPGYYSWRSPGR 237
             +       +P                          +AD L  YS   GY ++R   +
Sbjct: 311 YWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRD-DK 369

Query: 238 GSWFVQALCSILEEH-GKDLEIMQILTRVNDRV 269
           GS F+Q L  +L  + G+DL  +++LT VN RV
Sbjct: 370 GSDFIQTLVEVLRANPGRDL--LELLTEVNRRV 400


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,054,235
Number of Sequences: 37866
Number of extensions: 543695
Number of successful extensions: 1271
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1169
Number of HSP's gapped (non-prelim): 44
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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