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Search of human proteins with 4502581
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
(303 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15718698 caspase 7 isoform delta [Homo sapiens] 627 e-180
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 627 e-180
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 627 e-180
gi|15718702 caspase 7 isoform beta [Homo sapiens] 306 2e-83
gi|14790115 caspase 3 preproprotein [Homo sapiens] 282 3e-76
gi|14790119 caspase 3 preproprotein [Homo sapiens] 282 3e-76
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 184 8e-47
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 168 5e-42
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 167 1e-41
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 161 8e-40
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 161 8e-40
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 161 8e-40
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 161 8e-40
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 161 8e-40
gi|14916485 caspase 6 isoform beta [Homo sapiens] 154 9e-38
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 150 1e-36
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 134 1e-31
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 125 6e-29
gi|6912286 caspase 14 precursor [Homo sapiens] 100 3e-21
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 75 9e-14
gi|209870073 caspase 5 isoform c [Homo sapiens] 75 9e-14
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 75 9e-14
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 75 9e-14
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 69 4e-12
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 69 4e-12
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 69 4e-12
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 67 3e-11
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 67 3e-11
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap... 65 7e-11
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap... 65 7e-11
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 627 bits (1616), Expect = e-180
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 34 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 93
Query: 61 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 94 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 153
Query: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
Sbjct: 154 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 213
Query: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
Sbjct: 214 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 273
Query: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
Sbjct: 274 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 333
Query: 301 FSQ 303
FSQ
Sbjct: 334 FSQ 336
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 627 bits (1616), Expect = e-180
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 1 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
Query: 61 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 61 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
Query: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
Sbjct: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
Query: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
Sbjct: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
Query: 301 FSQ 303
FSQ
Sbjct: 301 FSQ 303
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 627 bits (1616), Expect = e-180
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 1 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
Query: 61 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 61 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
Query: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
Sbjct: 121 DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL 180
Query: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
Sbjct: 181 FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
Query: 301 FSQ 303
FSQ
Sbjct: 301 FSQ 303
>gi|15718702 caspase 7 isoform beta [Homo sapiens]
Length = 253
Score = 306 bits (783), Expect = 2e-83
Identities = 148/149 (99%), Positives = 149/149 (100%)
Query: 1 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
Sbjct: 1 MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY 60
Query: 61 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
Sbjct: 61 NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ 120
Query: 121 DLLKKASEEDHTNAACFACILLSHGEENV 149
DLLKKASEEDHTNAACFACILLSHGEEN+
Sbjct: 121 DLLKKASEEDHTNAACFACILLSHGEENM 149
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 282 bits (721), Expect = 3e-76
Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)
Query: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Y M++ ++G CIIINNKNF K TGM R+GTD DA L + FR+L ++V ND + ++
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179
+L++ S+EDH+ + F C+LLSHGEE +I+G +G +K +T FRGDRC++L KPK
Sbjct: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
Query: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239
LF IQACRGTELD GI+ DSG +D +KIPVEADFL+AYST PGYYSWR+ GS
Sbjct: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
Query: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299
WF+Q+LC++L+++ LE M ILTRVN +VA FES S D FH KKQIPC+VSMLTKEL
Sbjct: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
Query: 300 YF 301
YF
Sbjct: 274 YF 275
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 282 bits (721), Expect = 3e-76
Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)
Query: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Y M++ ++G CIIINNKNF K TGM R+GTD DA L + FR+L ++V ND + ++
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179
+L++ S+EDH+ + F C+LLSHGEE +I+G +G +K +T FRGDRC++L KPK
Sbjct: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
Query: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239
LF IQACRGTELD GI+ DSG +D +KIPVEADFL+AYST PGYYSWR+ GS
Sbjct: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
Query: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299
WF+Q+LC++L+++ LE M ILTRVN +VA FES S D FH KKQIPC+VSMLTKEL
Sbjct: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
Query: 300 YF 301
YF
Sbjct: 274 YF 275
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 184 bits (467), Expect = 8e-47
Identities = 98/256 (38%), Positives = 140/256 (54%), Gaps = 10/256 (3%)
Query: 56 PTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS 115
P +Y M+ + G +I N++ F + R GT D + L + F LGF+V +ND
Sbjct: 33 PAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLK 92
Query: 116 CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLL 175
++ + + S H +A CF C+ LSHGE N IY D I+ LT F+GD+C +L+
Sbjct: 93 AEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLV 152
Query: 176 EKPKLFFIQACRGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYST 225
KPK+F IQACRG + +D+ + I + DA Y +P ADFL YS
Sbjct: 153 GKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSV 212
Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
GYYS R GSW++Q LC +L ++G LE ++LT VN +V++ DP K
Sbjct: 213 AEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK 272
Query: 286 KQIPCVVSMLTKELYF 301
KQ+PC SMLTK+L+F
Sbjct: 273 KQVPCFASMLTKKLHF 288
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 168 bits (426), Expect = 5e-42
Identities = 99/274 (36%), Positives = 151/274 (55%), Gaps = 14/274 (5%)
Query: 33 PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 92
PSL S+ + + ++ + Y MN G C+I+NN +F T + R GT K
Sbjct: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305
Query: 93 DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIY 151
DAE L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365
Query: 152 GKD-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--N 208
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A +
Sbjct: 366 SSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS 425
Query: 209 PRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVND 267
+ IP EADFL +TVPGY S+R GSW++Q+LC+ L++ + +I+ ILT VND
Sbjct: 426 LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVND 485
Query: 268 RVARHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
V+R + Q KKQ+P L K+L F
Sbjct: 486 DVSRRVDKQG------TKKQMPQPAFTLRKKLVF 513
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 167 bits (422), Expect = 1e-41
Identities = 99/272 (36%), Positives = 153/272 (56%), Gaps = 15/272 (5%)
Query: 36 FSKKKKNVTMRSIKTTRDRVPTYQ-YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDA 94
+ +++ V+ +KT + +P Y MN G C+I+NN +F T + R GT KDA
Sbjct: 208 YQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDA 264
Query: 95 EALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIYGK 153
E L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 265 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 324
Query: 154 D-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--NPR 210
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A + +
Sbjct: 325 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ 384
Query: 211 YKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVNDRV 269
IP EADFL +TVPGY S+R GSW++Q+LC+ L++ + +I+ ILT VND V
Sbjct: 385 DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDV 444
Query: 270 ARHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
+R + Q KKQ+P L K+L F
Sbjct: 445 SRRVDKQG------TKKQMPQPAFTLRKKLVF 470
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 161 bits (407), Expect = 8e-40
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 345 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 404
Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 405 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 464
Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 465 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 518
Query: 285 KKQIPCVVSMLTKELYF 301
KQ+P L K+L F
Sbjct: 519 GKQMPQPTFTLRKKLVF 535
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 161 bits (407), Expect = 8e-40
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
Query: 285 KKQIPCVVSMLTKELYF 301
KQ+P L K+L F
Sbjct: 445 GKQMPQPTFTLRKKLVF 461
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 161 bits (407), Expect = 8e-40
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
Query: 285 KKQIPCVVSMLTKELYF 301
KQ+P L K+L F
Sbjct: 445 GKQMPQPTFTLRKKLVF 461
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 161 bits (407), Expect = 8e-40
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 286 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 345
Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 346 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 405
Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 406 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 459
Query: 285 KKQIPCVVSMLTKELYF 301
KQ+P L K+L F
Sbjct: 460 GKQMPQPTFTLRKKLVF 476
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 161 bits (407), Expect = 8e-40
Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)
Query: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112
Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++
Sbjct: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Query: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171
DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C
Sbjct: 303 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 362
Query: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225
+L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T
Sbjct: 363 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 422
Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284
V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D +
Sbjct: 423 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 476
Query: 285 KKQIPCVVSMLTKELYF 301
KQ+P L K+L F
Sbjct: 477 GKQMPQPTFTLRKKLVF 493
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 154 bits (389), Expect = 9e-38
Identities = 79/185 (42%), Positives = 106/185 (57%), Gaps = 10/185 (5%)
Query: 127 SEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQAC 186
S H +A CF C+ LSHGE N IY D I+ LT F+GD+C +L+ KPK+F IQAC
Sbjct: 15 STVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAC 74
Query: 187 RGTE----------LDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPG 236
RG + +D+ + I + DA Y +P ADFL YS GYYS R
Sbjct: 75 RGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETV 134
Query: 237 RGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLT 296
GSW++Q LC +L ++G LE ++LT VN +V++ DP KKQ+PC SMLT
Sbjct: 135 NGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLT 194
Query: 297 KELYF 301
K+L+F
Sbjct: 195 KKLHF 199
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 150 bits (380), Expect = 1e-36
Identities = 81/223 (36%), Positives = 126/223 (56%), Gaps = 7/223 (3%)
Query: 33 PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 92
PSL S+ + + ++ + Y MN G C+I+NN +F T + R GT K
Sbjct: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305
Query: 93 DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIY 151
DAE L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365
Query: 152 GKD-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--N 208
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A +
Sbjct: 366 SSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS 425
Query: 209 PRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE 251
+ IP EADFL +TVPGY S+R GSW++Q+LC+ L++
Sbjct: 426 LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 134 bits (337), Expect = 1e-31
Identities = 88/271 (32%), Positives = 130/271 (47%), Gaps = 39/271 (14%)
Query: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Y ++ E G C+IINN NF + +G+ R G++ D E L + F SL F V V D + KM
Sbjct: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Query: 120 QDLLKKASEEDHTNAACFACILLSHGEE-------NVIYGKDGV-TPIKDLTAHFRGDRC 171
L + +++DH C ++LSHG + +YG DG ++ + F G C
Sbjct: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
Query: 172 KTLLEKPKLFFIQACRGTELDDGIQADS--------GPINDTDANPRYK----------- 212
+L KPKLFFIQAC G + D G + S G + DA P +
Sbjct: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAI 332
Query: 213 --IPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVA 270
+P +D +YST PG+ SWR P GSW+V+ L I E+ ++ +L RV + V+
Sbjct: 333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS 392
Query: 271 RHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
KQ+P + L K+L+F
Sbjct: 393 VK----------GIYKQMPGCFNFLRKKLFF 413
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 125 bits (313), Expect = 6e-29
Identities = 77/255 (30%), Positives = 128/255 (50%), Gaps = 16/255 (6%)
Query: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Y + G ++++N +F + R+G D D L F+ LG+DV V D + +M
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Query: 120 QDLLKKASEEDHTNAACFACI--LLSHGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLE 176
Q+ L+ ++ + +CI LLSHG E IYG DG + ++++ F C +L
Sbjct: 252 QEKLQNFAQLP-AHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310
Query: 177 KPKLFFIQACRGTELDDGIQADSGP-------INDTDAN----PRYKIPVEADFLFAYST 225
KPK+FFIQACRG E D G+ G ++DA P+ ++P +D + Y+
Sbjct: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
Query: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
+ G + R+ RGSW+++AL + E D+ + +L +VN + + E + FH
Sbjct: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVN-ALIKDREGYAPGTEFHRC 429
Query: 286 KQIPCVVSMLTKELY 300
K++ S L + LY
Sbjct: 430 KEMSEYCSTLCRHLY 444
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 99.8 bits (247), Expect = 3e-21
Identities = 67/218 (30%), Positives = 106/218 (48%), Gaps = 10/218 (4%)
Query: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK---ASEEDHTNAACFACILLS 143
R G+++D +AL FR L F+ + D + + Q+ L+K A + +C +L++
Sbjct: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
Query: 144 HGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
HG E + G+DG + +++L C+ L KPK++ IQACRG + D G I
Sbjct: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEI 148
Query: 203 NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQIL 262
+ IP D L YSTV GY ++R +GS F+Q L + + + I+++L
Sbjct: 149 VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILELL 206
Query: 263 TRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
T V R+A Q +K P + S L K LY
Sbjct: 207 TEVTRRMAEAELVQEG----KARKTNPEIQSTLRKRLY 240
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 74.7 bits (182), Expect = 9e-14
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 162 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 219
Query: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 220 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 276
Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 277 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 336
Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 337 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 397 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 442
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 74.7 bits (182), Expect = 9e-14
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 7 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 64
Query: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 65 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 121
Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 122 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 181
Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 182 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 241
Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 242 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 287
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 74.7 bits (182), Expect = 9e-14
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 91 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 148
Query: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 149 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 205
Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 206 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 265
Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 266 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325
Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 326 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 371
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 74.7 bits (182), Expect = 9e-14
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 149 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 206
Query: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 207 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 263
Query: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 264 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 323
Query: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 324 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383
Query: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 384 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 429
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 73 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 129
Query: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 130 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 189
Query: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 190 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 249
Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
P GS F+ L ++E+ ++ +I +V
Sbjct: 250 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 280
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 166 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 222
Query: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 223 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 282
Query: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 283 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 342
Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
P GS F+ L ++E+ ++ +I +V
Sbjct: 343 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 373
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 145 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 201
Query: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 202 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 261
Query: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 262 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 321
Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
P GS F+ L ++E+ ++ +I +V
Sbjct: 322 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 352
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 66.6 bits (161), Expect = 3e-11
Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)
Query: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
+II N FD + RNG D D + + L + V V + + M+ L+ A+
Sbjct: 83 LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139
Query: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183
+H ++ +L+SHG I G K V + F C +L +KPK+ +
Sbjct: 140 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 199
Query: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234
QACRG + ++ A S + + + YK VE DF+ S+ P SWR
Sbjct: 200 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 259
Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
GS F+ L + +++ + ++ +V
Sbjct: 260 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 290
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 66.6 bits (161), Expect = 3e-11
Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)
Query: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
+II N FD + RNG D D + + L + V V + + M+ L+ A+
Sbjct: 139 LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195
Query: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183
+H ++ +L+SHG I G K V + F C +L +KPK+ +
Sbjct: 196 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 255
Query: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234
QACRG + ++ A S + + + YK VE DF+ S+ P SWR
Sbjct: 256 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 315
Query: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
GS F+ L + +++ + ++ +V
Sbjct: 316 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 346
>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 65.1 bits (157), Expect = 7e-11
Identities = 60/213 (28%), Positives = 91/213 (42%), Gaps = 34/213 (15%)
Query: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHT---NAACFACILLS 143
R G D EAL +LGF+ V D + Q+ L + E+ T +C L++
Sbjct: 192 RPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMA 251
Query: 144 HG-EENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
HG + G DG ++ RC+ L +PK+F +QACRG D G+ + P
Sbjct: 252 HGGPRGQLLGADG-QEVQPEALMQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPW 310
Query: 203 NDTDANPRYKIPV-------------------------EADFLFAYSTVPGYYSWRSPGR 237
+ +P +AD L YS GY ++R +
Sbjct: 311 YWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRD-DK 369
Query: 238 GSWFVQALCSILEEH-GKDLEIMQILTRVNDRV 269
GS F+Q L +L + G+DL +++LT VN RV
Sbjct: 370 GSDFIQTLVEVLRANPGRDL--LELLTEVNRRV 400
>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 65.1 bits (157), Expect = 7e-11
Identities = 60/213 (28%), Positives = 91/213 (42%), Gaps = 34/213 (15%)
Query: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHT---NAACFACILLS 143
R G D EAL +LGF+ V D + Q+ L + E+ T +C L++
Sbjct: 192 RPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVALMA 251
Query: 144 HG-EENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
HG + G DG ++ RC+ L +PK+F +QACRG D G+ + P
Sbjct: 252 HGGPRGQLLGADG-QEVQPEALMQELSRCQVLQGRPKIFLLQACRGGNRDAGVGPTALPW 310
Query: 203 NDTDANPRYKIPV-------------------------EADFLFAYSTVPGYYSWRSPGR 237
+ +P +AD L YS GY ++R +
Sbjct: 311 YWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQADILTVYSAAEGYVAYRD-DK 369
Query: 238 GSWFVQALCSILEEH-GKDLEIMQILTRVNDRV 269
GS F+Q L +L + G+DL +++LT VN RV
Sbjct: 370 GSDFIQTLVEVLRANPGRDL--LELLTEVNRRV 400
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,054,235
Number of Sequences: 37866
Number of extensions: 543695
Number of successful extensions: 1271
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1169
Number of HSP's gapped (non-prelim): 44
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.