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Search of human proteins with 4502577
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
(377 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 769 0.0
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 657 0.0
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 560 e-160
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 555 e-158
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 555 e-158
gi|209870073 caspase 5 isoform c [Homo sapiens] 477 e-135
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 368 e-102
gi|209870075 caspase 5 isoform d [Homo sapiens] 368 e-102
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 361 e-100
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 337 8e-93
gi|15431332 caspase 1 isoform delta [Homo sapiens] 269 3e-72
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 95 1e-19
gi|15431334 caspase 1 isoform epsilon [Homo sapiens] 90 4e-18
gi|14790115 caspase 3 preproprotein [Homo sapiens] 89 8e-18
gi|14790119 caspase 3 preproprotein [Homo sapiens] 89 8e-18
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 74 3e-13
gi|6912286 caspase 14 precursor [Homo sapiens] 72 1e-12
gi|15718698 caspase 7 isoform delta [Homo sapiens] 67 3e-11
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 67 3e-11
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 67 3e-11
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 64 2e-10
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 64 3e-10
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 63 4e-10
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 61 1e-09
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 52 7e-07
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 52 7e-07
gi|14916485 caspase 6 isoform beta [Homo sapiens] 51 1e-06
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 51 2e-06
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 51 2e-06
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 51 2e-06
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 769 bits (1985), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
Sbjct: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
Query: 61 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE 120
MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
Sbjct: 61 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE 120
Query: 121 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT 180
RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
Sbjct: 121 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT 180
Query: 181 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN 240
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
Sbjct: 181 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN 240
Query: 241 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 300
RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
Sbjct: 241 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 300
Query: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 360
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
Sbjct: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 360
Query: 361 TIERLSMTRYFYLFPGN 377
TIERLSMTRYFYLFPGN
Sbjct: 361 TIERLSMTRYFYLFPGN 377
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 657 bits (1694), Expect = 0.0
Identities = 321/321 (100%), Positives = 321/321 (100%)
Query: 57 MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 116
MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR
Sbjct: 1 MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
Query: 117 LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 176
LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE
Sbjct: 61 LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
Query: 177 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 236
ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ
Sbjct: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
Query: 237 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 296
IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV
Sbjct: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
Query: 297 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 356
EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK
Sbjct: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
Query: 357 AQMPTIERLSMTRYFYLFPGN 377
AQMPTIERLSMTRYFYLFPGN
Sbjct: 301 AQMPTIERLSMTRYFYLFPGN 321
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 560 bits (1443), Expect = e-160
Identities = 279/377 (74%), Positives = 312/377 (82%), Gaps = 1/377 (0%)
Query: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
MAE NH+KK +K+LE LGKD L GV + L + +VL KEEEKKKYYD K EDK ++ DS
Sbjct: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
Query: 61 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE 120
++ K R+A QM QT N+DQ + K +EAGPPES EST+ LKLCP EEFLRLCK+
Sbjct: 61 LR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKK 119
Query: 121 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT 180
+EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V E+NLT
Sbjct: 120 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT 179
Query: 181 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN 240
ARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQIFNN
Sbjct: 180 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN 239
Query: 241 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 300
RNCLSLKDKPKVIIVQACRG GELWVRDSPASL + SSQSSENLE D+V K H EKDF
Sbjct: 240 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF 299
Query: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 360
IAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AKAQMP
Sbjct: 300 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP 359
Query: 361 TIERLSMTRYFYLFPGN 377
TIER ++TR FYLFPGN
Sbjct: 360 TIERATLTRDFYLFPGN 376
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 555 bits (1430), Expect = e-158
Identities = 276/373 (73%), Positives = 309/373 (82%), Gaps = 1/373 (0%)
Query: 5 NHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEK 64
NH+KK +K+LE LGKD L GV + L + +VL KEEEKKKYYD K EDK ++ DS++ K
Sbjct: 76 NHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR-K 134
Query: 65 QRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEE 124
R+A QM QT N+DQ + K +EAGPPES EST+ LKLCP EEFLRLCK+ +E
Sbjct: 135 NRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDE 194
Query: 125 IYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDM 184
IYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V E+NLTARDM
Sbjct: 195 IYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 254
Query: 185 ESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCL 244
ES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQIFNNRNCL
Sbjct: 255 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 314
Query: 245 SLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFC 304
SLKDKPKVIIVQACRG GELWVRDSPASL + SSQSSENLE D+V K H EKDFIAFC
Sbjct: 315 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFC 374
Query: 305 SSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIER 364
SSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AKAQMPTIER
Sbjct: 375 SSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER 434
Query: 365 LSMTRYFYLFPGN 377
++TR FYLFPGN
Sbjct: 435 ATLTRDFYLFPGN 447
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 555 bits (1430), Expect = e-158
Identities = 276/373 (73%), Positives = 309/373 (82%), Gaps = 1/373 (0%)
Query: 5 NHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEK 64
NH+KK +K+LE LGKD L GV + L + +VL KEEEKKKYYD K EDK ++ DS++ K
Sbjct: 63 NHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR-K 121
Query: 65 QRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEE 124
R+A QM QT N+DQ + K +EAGPPES EST+ LKLCP EEFLRLCK+ +E
Sbjct: 122 NRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDE 181
Query: 125 IYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDM 184
IYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V E+NLTARDM
Sbjct: 182 IYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 241
Query: 185 ESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCL 244
ES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQIFNNRNCL
Sbjct: 242 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 301
Query: 245 SLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFC 304
SLKDKPKVIIVQACRG GELWVRDSPASL + SSQSSENLE D+V K H EKDFIAFC
Sbjct: 302 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFC 361
Query: 305 SSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIER 364
SSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AKAQMPTIER
Sbjct: 362 SSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER 421
Query: 365 LSMTRYFYLFPGN 377
++TR FYLFPGN
Sbjct: 422 ATLTRDFYLFPGN 434
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 477 bits (1228), Expect = e-135
Identities = 232/286 (81%), Positives = 252/286 (88%)
Query: 92 MEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPP 151
+EAGPPES EST+ LKLCP EEFLRLCK+ +EIYPIK+R +R RLALIICNT+FDHLP
Sbjct: 7 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPA 66
Query: 152 RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 211
RNGA +DI GMK LL+GL Y+V E+NLTARDMES LRAFA RPEHKSSDSTFLVLMSHG
Sbjct: 67 RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHG 126
Query: 212 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 271
ILEGICGT H +KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG GELWVRDS
Sbjct: 127 ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDS 186
Query: 272 PASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQ 331
PASL + SSQSSENLE D+V K H EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQ
Sbjct: 187 PASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQ 246
Query: 332 KYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 377
KYS CCHL E+FRKVQ+SFE P+AKAQMPTIER ++TR FYLFPGN
Sbjct: 247 KYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 368 bits (944), Expect = e-102
Identities = 196/384 (51%), Positives = 257/384 (66%), Gaps = 8/384 (2%)
Query: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
MA+ ++K + S+G+ + G+LD L++ VLN +E EK K +A DK R + DS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 MQEKQRMAGQMLLQTFFNIDQ-------ISPNKKAHPNMEAGPPESGESTDALKLCPHEE 113
+ K A Q+ + D +S +A + A P SG S +KLC EE
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSG-SEGNVKLCSLEE 119
Query: 114 FLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSV 173
R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+ DITGM LL+ L YSV
Sbjct: 120 AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV 179
Query: 174 DVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDT 233
DV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H E+ PD+L +
Sbjct: 180 DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNA 239
Query: 234 IFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYK 293
IF + N +NC SLKDKPKVII+QACRG + G +W +DS S ++E E+DA+ K
Sbjct: 240 IFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKK 299
Query: 294 THVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETP 353
H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+Y+ C +EE+FRKV+ SFE P
Sbjct: 300 AHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQP 359
Query: 354 RAKAQMPTIERLSMTRYFYLFPGN 377
+AQMPT ER+++TR FYLFPG+
Sbjct: 360 DGRAQMPTTERVTLTRCFYLFPGH 383
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 368 bits (944), Expect = e-102
Identities = 180/216 (83%), Positives = 192/216 (88%)
Query: 162 MKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVH 221
MK LL+GL Y+V E+NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H
Sbjct: 1 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60
Query: 222 DEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQ 281
+KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG GELWVRDSPASL + SSQ
Sbjct: 61 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120
Query: 282 SSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEE 341
SSENLE D+V K H EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180
Query: 342 VFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 377
+FRKVQ+SFE P+AKAQMPTIER ++TR FYLFPGN
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 361 bits (927), Expect = e-100
Identities = 198/405 (48%), Positives = 259/405 (63%), Gaps = 29/405 (7%)
Query: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
MA+ ++K + S+G+ + G+LD L++ VLN +E EK K +A DK R + DS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 MQEKQRMAGQMLLQTF------------FNIDQIS----------------PNKKAHPNM 92
+ K A Q+ + + DQ S P +A +
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
Query: 93 EAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPR 152
A P SG S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R
Sbjct: 121 PAMPTSSG-SEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRR 179
Query: 153 NGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGI 212
GA+ DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI
Sbjct: 180 TGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGI 239
Query: 213 LEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSP 272
EGICG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG + G +W +DS
Sbjct: 240 REGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV 299
Query: 273 ASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQK 332
S ++E E+DA+ K H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+
Sbjct: 300 GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
Query: 333 YSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 377
Y+ C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 360 YACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 337 bits (865), Expect = 8e-93
Identities = 166/281 (59%), Positives = 208/281 (74%)
Query: 97 PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 156
P S S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
Query: 157 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 216
DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
Query: 217 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 276
CG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG + G +W +DS
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
Query: 277 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 336
S ++E E+DA+ K H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+Y+
Sbjct: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
Query: 337 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 377
C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 269 bits (687), Expect = 3e-72
Identities = 143/281 (50%), Positives = 177/281 (62%), Gaps = 48/281 (17%)
Query: 97 PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 156
P S S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
Query: 157 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 216
DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
Query: 217 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 276
CG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRG---------------- 194
Query: 277 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 336
NVSWR TMGS+FI +LI Q+Y+
Sbjct: 195 --------------------------------DNVSWRHPTMGSVFIGRLIEHMQEYACS 222
Query: 337 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 377
C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 223 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 263
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 94.7 bits (234), Expect = 1e-19
Identities = 73/254 (28%), Positives = 117/254 (46%), Gaps = 18/254 (7%)
Query: 137 LALIICNTEFD---HLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 193
LAL++ N F L R+G D D + + L + L Y V V + TA++M+ L+ FA
Sbjct: 201 LALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQ 260
Query: 194 RPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 253
P H+ +DS + L+SHG+ I G D K +L +FQ+F+N NC SL++KPK+
Sbjct: 261 LPAHRVTDSCIVALLSHGVEGAIYGV--DGK---LLQLQEVFQLFDNANCPSLQNKPKMF 315
Query: 254 IVQACRG--ANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNV 311
+QACRG +RG + +S E+ + D I +
Sbjct: 316 FIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTA 375
Query: 312 SWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERL------ 365
+ R++ GS +I L F + + H+ ++ KV + A R
Sbjct: 376 AMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEY 435
Query: 366 --SMTRYFYLFPGN 377
++ R+ YLFPG+
Sbjct: 436 CSTLCRHLYLFPGH 449
>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
Length = 88
Score = 89.7 bits (221), Expect = 4e-18
Identities = 44/81 (54%), Positives = 57/81 (70%)
Query: 297 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 356
EK + S NVSWR TMGS+FI +LI Q+Y+ C +EE+FRKV+ SFE P +
Sbjct: 8 EKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 67
Query: 357 AQMPTIERLSMTRYFYLFPGN 377
AQMPT ER+++TR FYLFPG+
Sbjct: 68 AQMPTTERVTLTRCFYLFPGH 88
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 88.6 bits (218), Expect = 8e-18
Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 137 LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 193
L +II N F + R+G D D ++E L Y V + +LT ++ +R +
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
Query: 194 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 250
+ +H S VL+SHG I+ G G V D KK I F C SL KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155
Query: 251 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 310
K+ I+QACRG L+ S ++ A +K VE DF+ S+ P
Sbjct: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
Query: 311 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 360
SWR+S GS FI L ++Y+ + L V RKV FE T AK Q+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
Query: 361 TI-ERLSMTRYFY 372
I L+ YFY
Sbjct: 264 CIVSMLTKELYFY 276
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 88.6 bits (218), Expect = 8e-18
Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 137 LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 193
L +II N F + R+G D D ++E L Y V + +LT ++ +R +
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
Query: 194 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 250
+ +H S VL+SHG I+ G G V D KK I F C SL KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155
Query: 251 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 310
K+ I+QACRG L+ S ++ A +K VE DF+ S+ P
Sbjct: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
Query: 311 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 360
SWR+S GS FI L ++Y+ + L V RKV FE T AK Q+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
Query: 361 TI-ERLSMTRYFY 372
I L+ YFY
Sbjct: 264 CIVSMLTKELYFY 276
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 73.6 bits (179), Expect = 3e-13
Identities = 67/240 (27%), Positives = 106/240 (44%), Gaps = 20/240 (8%)
Query: 139 LIICNTEF---DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195
LII N F L R G++ D ++ L + V+V+ +LTA+ M AL A +
Sbjct: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
Query: 196 EHKSSDSTFLVLMSHGILEG---ICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 252
+H + D +V++SHG G V+ V + + I IFN +C SL KPK+
Sbjct: 223 DHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSV-EKIVNIFNGTSCPSLGGKPKL 281
Query: 253 IIVQACRGANRGELW-------VRDSPAS-LEVASSQSSENL----EEDAVYKTHVEKDF 300
+QAC G + + +SP S E ++ E L + DA+ D
Sbjct: 282 FFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDI 341
Query: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 360
S+ P VSWRD GS ++ L F++++ L+ + +V + QMP
Sbjct: 342 FVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 71.6 bits (174), Expect = 1e-12
Identities = 67/251 (26%), Positives = 112/251 (44%), Gaps = 49/251 (19%)
Query: 136 RLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195
RLALI+C T+ R G++ D+ ++ + L + ++ + TA + L F
Sbjct: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
Query: 196 EHKSS--DSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 250
+ + F+VLM+HG L+G G +++ + +F+ NN+NC +L+ KP
Sbjct: 73 DSREDPVSCAFVVLMAHGREGFLKGEDG--------EMVKLENLFEALNNKNCQALRAKP 124
Query: 251 KVIIVQACRGANR--GE--------LWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 300
KV I+QACRG R GE + ++DSP ++ + DA++ + +
Sbjct: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYT---------DALHVYSTVEGY 175
Query: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCC--HLEEVFRKVQQSFETPRAKAQ 358
IA+ R GS FI L+ F K L EV R++ ++ KA+
Sbjct: 176 IAY----------RHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKAR 225
Query: 359 MPTIERLSMTR 369
E S R
Sbjct: 226 KTNPEIQSTLR 236
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 66.6 bits (161), Expect = 3e-11
Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)
Query: 139 LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195
+II N FD + RNG D D + + L + V V + + M+ L+ A+
Sbjct: 104 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 162
Query: 196 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 255
+H ++ +L+SHG I G K V + F C +L +KPK+ +
Sbjct: 163 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 216
Query: 256 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 315
QACRG + ++ A S + + + YK VE DF+ S+ P SWR
Sbjct: 217 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 267
Query: 316 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 346
GS F+ L + +++ + ++ +V
Sbjct: 268 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 298
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 66.6 bits (161), Expect = 3e-11
Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)
Query: 139 LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195
+II N FD + RNG D D + + L + V V + + M+ L+ A+
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 196 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 255
+H ++ +L+SHG I G K V + F C +L +KPK+ +
Sbjct: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183
Query: 256 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 315
QACRG + ++ A S + + + YK VE DF+ S+ P SWR
Sbjct: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234
Query: 316 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 346
GS F+ L + +++ + ++ +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 66.6 bits (161), Expect = 3e-11
Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)
Query: 139 LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195
+II N FD + RNG D D + + L + V V + + M+ L+ A+
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 196 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 255
+H ++ +L+SHG I G K V + F C +L +KPK+ +
Sbjct: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183
Query: 256 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 315
QACRG + ++ A S + + + YK VE DF+ S+ P SWR
Sbjct: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234
Query: 316 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 346
GS F+ L + +++ + ++ +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 63.9 bits (154), Expect = 2e-10
Identities = 73/350 (20%), Positives = 134/350 (38%), Gaps = 31/350 (8%)
Query: 3 EGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQ 62
+G + L LE L K + +L +N+ +K E+ + + + A+S Q
Sbjct: 159 QGKIDEDNLTCLEDLCKTVVPKLL-----RNIEKYKREKAIQIVTPPVDKE----AESYQ 209
Query: 63 EKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERA 122
++ + Q ++TF + H +G + + L E +
Sbjct: 210 GEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETS 269
Query: 123 EEIYPIKERNNRTR-LALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA 181
+ + N R L +I+ N F L R G D + + + L ++V + N+T
Sbjct: 270 TKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTK 329
Query: 182 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR 241
+ME L+ P H D +++HG G V+ + + + + I F
Sbjct: 330 VEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTAL 384
Query: 242 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI 301
C L +KPK+ +QAC+G P+ A + + E E DF+
Sbjct: 385 QCPRLAEKPKLFFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFL 437
Query: 302 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFE 351
++ P VS+R GS +I L C HL+++ ++ + E
Sbjct: 438 LGLATVPGYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 63.5 bits (153), Expect = 3e-10
Identities = 70/331 (21%), Positives = 126/331 (38%), Gaps = 22/331 (6%)
Query: 3 EGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQ 62
+G + L LE L K + +L +N+ +K E+ + + + A+S Q
Sbjct: 159 QGKIDEDNLTCLEDLCKTVVPKLL-----RNIEKYKREKAIQIVTPPVDKE----AESYQ 209
Query: 63 EKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERA 122
++ + Q ++TF + H +G + + L E +
Sbjct: 210 GEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETS 269
Query: 123 EEIYPIKERNNRTR-LALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA 181
+ + N R L +I+ N F L R G D + + + L ++V + N+T
Sbjct: 270 TKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTK 329
Query: 182 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR 241
+ME L+ P H D +++HG G V+ + + + + I F
Sbjct: 330 VEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTAL 384
Query: 242 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI 301
C L +KPK+ +QAC+G P+ A + + E E DF+
Sbjct: 385 QCPRLAEKPKLFFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFL 437
Query: 302 AFCSSTPHNVSWRDSTMGSIFITQLITCFQK 332
++ P VS+R GS +I L +K
Sbjct: 438 LGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 63.2 bits (152), Expect = 4e-10
Identities = 49/200 (24%), Positives = 81/200 (40%), Gaps = 12/200 (6%)
Query: 133 NRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 192
N L +I+ N F L R G D + + + L ++V + N+T +ME L+
Sbjct: 238 NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQK 297
Query: 193 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 252
P H D +++HG G V+ + + + + I F C L +KPK+
Sbjct: 298 CNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAEKPKL 352
Query: 253 IIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVS 312
+QAC+G P+ A + + E E DF+ ++ P VS
Sbjct: 353 FFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVS 405
Query: 313 WRDSTMGSIFITQLITCFQK 332
+R GS +I L +K
Sbjct: 406 FRHVEEGSWYIQSLCNHLKK 425
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 61.2 bits (147), Expect = 1e-09
Identities = 83/309 (26%), Positives = 127/309 (41%), Gaps = 45/309 (14%)
Query: 86 KKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTE 145
++ HP AG E+ TDA + R + AE+ K + R +ALI +
Sbjct: 8 RRGHP---AGGEENMTETDAF-------YKREMFDPAEKY---KMDHRRRGIALIFNHER 54
Query: 146 FDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDS 202
F LP R G D + L + V +L A ++ + +T H +D
Sbjct: 55 FFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVST-VSHADADC 113
Query: 203 TFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN 262
V +SHG EG +D K + T+ +F C SL KPK+ I+QACRG N
Sbjct: 114 FVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG-N 166
Query: 263 RGELWVRDSPASLEVASSQSSE------NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDS 316
+ ++ V L+V +Q+ + ++ +VY DF+ S S R++
Sbjct: 167 QHDVPV----IPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 222
Query: 317 TMGSIFITQLITCFQKYSWCCHLEE----VFRKVQQS----FETPRA--KAQMPTIERLS 366
GS +I L KY E V RKV Q + P A K Q+P +
Sbjct: 223 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASM- 281
Query: 367 MTRYFYLFP 375
+T+ + FP
Sbjct: 282 LTKKLHFFP 290
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 52.4 bits (124), Expect = 7e-07
Identities = 65/315 (20%), Positives = 122/315 (38%), Gaps = 29/315 (9%)
Query: 29 LVEQNVLNWKEEEKKKYYDAKTEDKVRVMA-----DSMQEKQRMAGQMLLQTFFNIDQIS 83
L+++ + K ++ D E + RV+ D ++ + LL+ + ++ S
Sbjct: 182 LLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFS 241
Query: 84 PNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTR-LALIIC 142
K+ ++E P E + + + R ++ + + + ++ R LII
Sbjct: 242 --KERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299
Query: 143 NTEF----------DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 192
N F + RNG D + E L + + ++ T + L+ +
Sbjct: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359
Query: 193 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 252
+H + D ++SHG I GT E +Y+ Q F C SL KPKV
Sbjct: 360 LM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKV 413
Query: 253 IIVQACRGANRGELWVRDSPASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNV 311
+QAC+G N + + P + E +L E DF+ ++ + V
Sbjct: 414 FFIQACQGDN----YQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCV 469
Query: 312 SWRDSTMGSIFITQL 326
S+R+ G+ +I L
Sbjct: 470 SYRNPAEGTWYIQSL 484
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 52.4 bits (124), Expect = 7e-07
Identities = 65/315 (20%), Positives = 122/315 (38%), Gaps = 29/315 (9%)
Query: 29 LVEQNVLNWKEEEKKKYYDAKTEDKVRVMA-----DSMQEKQRMAGQMLLQTFFNIDQIS 83
L+++ + K ++ D E + RV+ D ++ + LL+ + ++ S
Sbjct: 123 LLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFS 182
Query: 84 PNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTR-LALIIC 142
K+ ++E P E + + + R ++ + + + ++ R LII
Sbjct: 183 --KERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240
Query: 143 NTEF----------DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 192
N F + RNG D + E L + + ++ T + L+ +
Sbjct: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300
Query: 193 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 252
+H + D ++SHG I GT E +Y+ Q F C SL KPKV
Sbjct: 301 LM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKV 354
Query: 253 IIVQACRGANRGELWVRDSPASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNV 311
+QAC+G N + + P + E +L E DF+ ++ + V
Sbjct: 355 FFIQACQGDN----YQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCV 410
Query: 312 SWRDSTMGSIFITQL 326
S+R+ G+ +I L
Sbjct: 411 SYRNPAEGTWYIQSL 425
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 51.2 bits (121), Expect = 1e-06
Identities = 56/195 (28%), Positives = 84/195 (43%), Gaps = 28/195 (14%)
Query: 197 HKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQ 256
H +D V +SHG EG +D K + T+ +F C SL KPK+ I+Q
Sbjct: 19 HADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKPKIFIIQ 72
Query: 257 ACRGANRGELWVRDSPASLEVASSQSSE------NLEEDAVYKTHVEKDFIAFCSSTPHN 310
ACRG N+ ++ V L+V +Q+ + ++ +VY DF+ S
Sbjct: 73 ACRG-NQHDVPV----IPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 127
Query: 311 VSWRDSTMGSIFITQLITCFQKYSWCCHLEE----VFRKVQQS----FETPRA--KAQMP 360
S R++ GS +I L KY E V RKV Q + P A K Q+P
Sbjct: 128 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 187
Query: 361 TIERLSMTRYFYLFP 375
+ +T+ + FP
Sbjct: 188 CFASM-LTKKLHFFP 201
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 50.8 bits (120), Expect = 2e-06
Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)
Query: 152 RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 211
RNG D + E L + + ++ T + L+ + +H + D ++SHG
Sbjct: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 303
Query: 212 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 271
I GT E +Y+ Q F C SL KPKV +QAC+G N + +
Sbjct: 304 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 354
Query: 272 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 326
P + E +L E DF+ ++ + VS+R+ G+ +I L
Sbjct: 355 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 50.8 bits (120), Expect = 2e-06
Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)
Query: 152 RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 211
RNG D + E L + + ++ T + L+ + +H + D ++SHG
Sbjct: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 303
Query: 212 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 271
I GT E +Y+ Q F C SL KPKV +QAC+G N + +
Sbjct: 304 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 354
Query: 272 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 326
P + E +L E DF+ ++ + VS+R+ G+ +I L
Sbjct: 355 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 50.8 bits (120), Expect = 2e-06
Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)
Query: 152 RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 211
RNG D + E L + + ++ T + L+ + +H + D ++SHG
Sbjct: 277 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 335
Query: 212 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 271
I GT E +Y+ Q F C SL KPKV +QAC+G N + +
Sbjct: 336 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 386
Query: 272 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 326
P + E +L E DF+ ++ + VS+R+ G+ +I L
Sbjct: 387 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 442
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,699,558
Number of Sequences: 37866
Number of extensions: 620646
Number of successful extensions: 1980
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1889
Number of HSP's gapped (non-prelim): 83
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.