Search of human proteins with 4502443

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
         (2649 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502443 dystonin isoform 1e precursor [Homo sapiens]              5183   0.0  
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]            2235   0.0  
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]            2191   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                       2124   0.0  
gi|221316622 dystonin isoform 3 [Homo sapiens]                       2124   0.0  
gi|221316618 dystonin isoform 2 [Homo sapiens]                       2124   0.0  
gi|34577047 dystonin isoform 1 [Homo sapiens]                        2124   0.0  
gi|33188445 microfilament and actin filament cross-linker protei...  1070   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       923   0.0  
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       923   0.0  
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        923   0.0  
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        923   0.0  
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        923   0.0  
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        923   0.0  
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        923   0.0  
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        923   0.0  
gi|58530840 desmoplakin isoform I [Homo sapiens]                      858   0.0  
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   667   0.0  
gi|58530842 desmoplakin isoform II [Homo sapiens]                     606   e-172
gi|45439327 periplakin [Homo sapiens]                                 372   e-102
gi|156104874 envoplakin [Homo sapiens]                                300   1e-80
gi|207452735 epiplakin 1 [Homo sapiens]                               261   6e-69
gi|71061468 centromere protein E [Homo sapiens]                       179   4e-44
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            171   1e-41
gi|148746195 trichohyalin [Homo sapiens]                              161   9e-39
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   159   5e-38
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   158   6e-38
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   155   7e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   155   7e-37
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   155   7e-37

>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 5183 bits (13444), Expect = 0.0
 Identities = 2649/2649 (100%), Positives = 2649/2649 (100%)

Query: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60
            MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML
Sbjct: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60

Query: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120
            QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI
Sbjct: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120

Query: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180
            DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL
Sbjct: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180

Query: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240
            NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN
Sbjct: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240

Query: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300
            FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE
Sbjct: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360
            WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK
Sbjct: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR
Sbjct: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA
Sbjct: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540
            YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN
Sbjct: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540

Query: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
            LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS
Sbjct: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660
            PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660

Query: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720
            DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ
Sbjct: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720

Query: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780
            YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI
Sbjct: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
Sbjct: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
            YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
Sbjct: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
            QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
            GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
Sbjct: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
            KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080

Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI 1140
            YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI
Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI 1140

Query: 1141 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200
            SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL
Sbjct: 1141 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200

Query: 1201 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD 1260
            ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD
Sbjct: 1201 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD 1260

Query: 1261 LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR 1320
            LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR
Sbjct: 1261 LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR 1320

Query: 1321 RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ 1380
            RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ
Sbjct: 1321 RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ 1380

Query: 1381 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE 1440
            DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE
Sbjct: 1381 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE 1440

Query: 1441 LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN 1500
            LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN
Sbjct: 1441 LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN 1500

Query: 1501 IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE 1560
            IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE
Sbjct: 1501 IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE 1560

Query: 1561 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG 1620
            ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG
Sbjct: 1561 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG 1620

Query: 1621 FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE 1680
            FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE
Sbjct: 1621 FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE 1680

Query: 1681 VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF 1740
            VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF
Sbjct: 1681 VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF 1740

Query: 1741 QEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI 1800
            QEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI
Sbjct: 1741 QEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI 1800

Query: 1801 KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860
            KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL
Sbjct: 1801 KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860

Query: 1861 VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP 1920
            VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP
Sbjct: 1861 VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP 1920

Query: 1921 LEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLS 1980
            LEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLS
Sbjct: 1921 LEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLS 1980

Query: 1981 EIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVP 2040
            EIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVP
Sbjct: 1981 EIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVP 2040

Query: 2041 SAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQ 2100
            SAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQ
Sbjct: 2041 SAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQ 2100

Query: 2101 LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERI 2160
            LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERI
Sbjct: 2101 LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERI 2160

Query: 2161 IIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSY 2220
            IIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSY
Sbjct: 2161 IIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSY 2220

Query: 2221 SSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQ 2280
            SSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQ
Sbjct: 2221 SSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQ 2280

Query: 2281 FLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRIS 2340
            FLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRIS
Sbjct: 2281 FLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRIS 2340

Query: 2341 VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH 2400
            VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH
Sbjct: 2341 VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH 2400

Query: 2401 FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERI 2460
            FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERI
Sbjct: 2401 FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERI 2460

Query: 2461 SVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQC 2520
            SVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQC
Sbjct: 2461 SVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQC 2520

Query: 2521 ELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEAL 2580
            ELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEAL
Sbjct: 2521 ELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEAL 2580

Query: 2581 QVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640
            QVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT
Sbjct: 2581 QVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640

Query: 2641 GISSLYYSS 2649
            GISSLYYSS
Sbjct: 2641 GISSLYYSS 2649


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score = 2235 bits (5791), Expect = 0.0
 Identities = 1280/2059 (62%), Positives = 1468/2059 (71%), Gaps = 172/2059 (8%)

Query: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60
            MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML
Sbjct: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60

Query: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120
            QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI
Sbjct: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120

Query: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180
            DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL
Sbjct: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180

Query: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240
            NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN
Sbjct: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240

Query: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300
            FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE
Sbjct: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360
            WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK
Sbjct: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR
Sbjct: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA
Sbjct: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540
            YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN
Sbjct: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540

Query: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
            LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS
Sbjct: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660
            PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660

Query: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720
            DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ
Sbjct: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720

Query: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780
            YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI
Sbjct: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
Sbjct: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
            YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
Sbjct: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
            QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
            GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
Sbjct: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
            KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080

Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LENSKLT 1137
            YTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L++++  
Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140

Query: 1138 GK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNVE---- 1180
            GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + ++    
Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1200

Query: 1181 -----------------DISLQKIRAESEAKQYRRELETI-------------------- 1203
                             D+ +++       ++Y+ +L+ I                    
Sbjct: 1201 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1260

Query: 1204 ------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFTRRTLE 1253
                  +++ ++ + EL++  Q + +A A+     EN L       +Q ++    ++  E
Sbjct: 1261 GDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNE 1320

Query: 1254 DHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQ 1313
              +K + L+L   EQ K +L + +      E E +  +KQ+E+     K   E  L    
Sbjct: 1321 AKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENLLDWLS 1375

Query: 1314 KIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ---KA 1361
             ++ ++ R  T+ +    +N        Q    ++  G         L+ + D Q     
Sbjct: 1376 NVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1431

Query: 1362 EELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKLDETNN 1415
            E L QQ  ++ A + K     + +     + Q  LEK     S EEK +L K+ + E   
Sbjct: 1432 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKV 1490

Query: 1416 TLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK-----------K 1464
                   E E+K +      ++L +      +     +++ QE  +L+           K
Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1550

Query: 1465 IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQ 1524
            +KR      + ++H KG L+       R    A+   +    ++ +    +E+      Q
Sbjct: 1551 LKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV------Q 1603

Query: 1525 RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNECAEML 1572
            RK DH  ++F   + +        K+  DK Q   +            E   S   +E +
Sbjct: 1604 RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPI 1663

Query: 1573 KQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHL 1632
                + L RQ  ETK +  +I   S+ + +EK         LK  A+   D   S     
Sbjct: 1664 AVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGSLLPAK 1712

Query: 1633 HKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASK 1692
            +   KT  D   +     EDL+KS N  +E  Q    +++ +Q+   E+ +    + +S 
Sbjct: 1713 NDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL 1768

Query: 1693 EEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHR 1735
            +E+ +                  EQ +  +Q+ +  +N ++KK      ++T +      
Sbjct: 1769 KEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDPSTASS 1823

Query: 1736 KMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKL 1795
                 ++ S +F +++ + ++ + K+ E K   E     +     +  +  ++A     +
Sbjct: 1824 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQALTEVDV 1882

Query: 1796 CETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
               ++ EL + +Q+   E ++  +H+E  H    +     L + K  V      + ++ K
Sbjct: 1883 PGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFK 1942

Query: 1855 EHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-PRSPLL 1912
            E E  +       +KK     C  + D F++ VK  +   + +++    + P+     L 
Sbjct: 1943 EMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 1996

Query: 1913 RWTQEPQPLEEKWQHRVVE 1931
            +  ++ + L+EKW  +  E
Sbjct: 1997 KSLEDTKKLQEKWSLKTPE 2015



 Score = 98.6 bits (244), Expect = 7e-20
 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1525 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1584

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1585 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1644

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 1645 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 1700

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 1701 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 1756

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 1757 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 1814

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 1815 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 1870

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 1871 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 1920

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 1921 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 1979

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 1980 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2035

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2036 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2070

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2071 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2121

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2122 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2181

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2182 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2239

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050
                 +   L TQ  Q ++L+ E   ++ + ++     +   S   +D  L+ +    + 
Sbjct: 2240 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2299

Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105
               QK      ++    D I Q  +   T+Y +L+  ++  +     K +         +
Sbjct: 2300 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2358

Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162
             + +  ET++       +Q++K  +     L   +S L   E + AEL +Q   + +   
Sbjct: 2359 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2416

Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222
             V + AEN ++  Q            +  + +Q  R+ +  +  K   + E  +   ++ 
Sbjct: 2417 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2465

Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
            + +   + ++++    +    ++    +T+ +    ++L L     +K  L  +L   + 
Sbjct: 2466 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2522

Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342
            N +   K +K+ E  L   K+  EK LK K+++E      I + Q    E    + P   
Sbjct: 2523 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2578

Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389
              S   +  LQ+E D+     E L    + L           T  N+   Q +  +T +L
Sbjct: 2579 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2638

Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437
            ++ +    +  +K +  ++   E+   L+C K +L+  D    + YS           + 
Sbjct: 2639 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 2698

Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492
            L+ L  Q++     A++ + EASD K    +  L++E++  E   L ++VD       T+
Sbjct: 2699 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 2757

Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548
               +   +  I+ + SQ   F D  EL+ +    R ++ L++Q E  K+  + L+ + A 
Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 2815

Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608
             +N +K  ++    E+++     +K+ +E L++Q N+   ++ R QA  E +   + TI 
Sbjct: 2816 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 2868

Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665
            +R E    +   F   L+   EH        ++ Q  +    E + +  N+   F++   
Sbjct: 2869 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 2920

Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
               +  QQ++      +IQ+  K    + L  +L+      +   +KV  + AQ+QE   
Sbjct: 2921 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 2980

Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772
               + QD L         T   +   +  S +FK  ++  + +K +++L++ +  T   I
Sbjct: 2981 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3040

Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830
               G ++   +   +  +  +   L ++  + L  + +    Q++    +    ++  + 
Sbjct: 3041 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3100

Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857
            L + L   ++ + N +       K+++QI +H+
Sbjct: 3101 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3133



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 2894

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 2895 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 2951 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3008

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3009 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3064

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E          TQ   
Sbjct: 3065 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3124

Query: 991  QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027
             E Q    K L             A  + Q   ++S  E   M QSK+D       E Q+
Sbjct: 3125 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3184

Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071
             +   S  ++          + E++ M +   V       S Q    +    Q S   ++
Sbjct: 3185 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3244

Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115
            QE + LR +    AL+  +    +  GD +  +++  E IK R K+ ++           
Sbjct: 3245 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3304

Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161
                    H  + +L   L + +  +L  E   L G + S+ +    ELKK+    +  L
Sbjct: 3305 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3364

Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221
              + E +   L        +  L+K+ AE + ++YR   +TI ++ E  +  + R +Q  
Sbjct: 3365 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3422

Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271
              A+A+ + +   E+ L++  +   E   T   L+       + L+ KD+ ++DL +  +
Sbjct: 3423 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3481

Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331
            K+M        +EEE   + K+++K L     +   Q+  ++ ++LE  + +    +   
Sbjct: 3482 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3534

Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390
            E   P    TQ+  S      L+ E  +Q+ EE  +Q+ EL A ++     M +   +L 
Sbjct: 3535 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3593

Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449
             L   +  S ++  +  D L  +    ++   + L+        +  ++ ++   L +  
Sbjct: 3594 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3653

Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493
             +  +    +++++KIK      +N  +++E L   +E  K + E         D+   A
Sbjct: 3654 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 3713

Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551
             AV +K   +  +   IH+  +E+E + L + +     L E+F   H  L+  I   K+ 
Sbjct: 3714 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 3765

Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603
             D I+ L +       +++  E AE ++++++ L  + +    L  + I A  E +  + 
Sbjct: 3766 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 3825

Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650
            K++I +   A       +KD++    E +    + +   Q               +  + 
Sbjct: 3826 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 3885

Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703
             DL   +  + E KQ   +     Q  + E  N  AEL   K  +   +  VQ       
Sbjct: 3886 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 3943

Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754
             +  +  + + NR  K++  L         L  +   +TH + +L +++       A E 
Sbjct: 3944 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4003

Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808
                  ++++ V+           +G  L   S  +E S  Q   ++     + +  + +
Sbjct: 4004 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4063

Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
            Q ++Q+          + + + L+  L   +R +  L  K    + E   + + +  E+ 
Sbjct: 4064 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4121

Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928
                AK+ T+K               L  +    L   P+S      Q+   L+EKW+  
Sbjct: 4122 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4167

Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968
              +   ++ + +      +E   S Q +  + +Q    L +
Sbjct: 4168 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4208



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2329 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2385

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2386 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2445

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++          K I+
Sbjct: 2446 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2496

Query: 918  DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976
            +      K +  +    + + + +   W   + Q+  R   L E + K+LK Y++    L
Sbjct: 2497 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2555

Query: 977  DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017
              WI + +    +I+        EN     K+L  +++Q              L+S  E+
Sbjct: 2556 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2615

Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070
             K+   DE +   ++          K + L+ MT +   + Q+ S   +R++Q + + L 
Sbjct: 2616 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 2674

Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124
            I + +  +      +T++       Q +K   D  KRL ++ +    E S+    SD+L 
Sbjct: 2675 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 2731

Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170
            + +    E+S L+ ++ E               +  + E+  Q +  ++EL  +     +
Sbjct: 2732 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 2791

Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229
             E  ++Q+      L+K+ A   +     +   ++   E    +L  +++  +EA +K+ 
Sbjct: 2792 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 2850

Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
                +    R +  E T  +R  E + K K+ S   +  QK +  EE +     E E + 
Sbjct: 2851 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 2906

Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349
              +Q+     FQK+  E    ++Q +                 N L    I  A    + 
Sbjct: 2907 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 2947

Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396
             GL+ + D          K+ A+   Q  + L    R  +     L++ ++  +L   +K
Sbjct: 2948 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3007

Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442
              S E         + +LL+  LD+  +T+  +K E E+     + A+K    +QL  L 
Sbjct: 3008 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3067

Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489
             +      KAE   ++   +  + + +   LE LN      EK        G    +++ 
Sbjct: 3068 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3127

Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537
                H   E +I + N  +H            S R++K++ + ++   +  +++ Q EKS
Sbjct: 3128 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3186

Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591
            H   +LLQ     A+    D+++ +N   E  ++ +++  Q    E L +Q +E +++ +
Sbjct: 3187 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3246

Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646
             I    +N+    Q +    E LK Q  G      +D+L +        TK   D     
Sbjct: 3247 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3299

Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705
            K LE+ L  ++ L S  ++ C     + ++    E + L  E  AS+ + R  E K + +
Sbjct: 3300 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3358

Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761
              +   L + L +V   L L+ +  +       +  E++ +++  ++   +K+E++    
Sbjct: 3359 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3415

Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810
                        E   ITE +   + L  + L+Q+ + AQ   ++ +T   E+ R     
Sbjct: 3416 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3473

Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             + ++ G  +                  + E +++K+K+D+ +K ++
Sbjct: 3474 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3507



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3189 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3248

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3249 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3301

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3302 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3356

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3357 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3400

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D++  + +  + +  ++ M   +  L+   T A L +
Sbjct: 3401 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3458

Query: 543  GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3459 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3511

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3512 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3561

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3562 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3614

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3615 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3671

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 3672 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 3731

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 3732 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 3778

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 3836

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 3893

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 3894 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 3953

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113
            + R+     A L + +F        A +T    L+++     GD  K +E E  K     
Sbjct: 3954 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4007

Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
              H   +D+L  Q +TV   +K    + E     +   ++ S ++ +L  + +  +N L 
Sbjct: 4008 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4060

Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222
            K ++  + +      A  +AK +  E+E + +     ER L               QL +
Sbjct: 4061 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4116

Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
              E   AA E     +++ +++      R  +      D  +N+L+++   +  +L  ++
Sbjct: 4117 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4175

Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337
               EE L L  +     +D       AE+ L    +  L     + +I ++    N +  
Sbjct: 4176 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4235

Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
                     +  T L+    KQ    +K  +  + +   K  Q + E    L+  +    
Sbjct: 4236 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4295

Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451
               E    L + L+E+  +L   +LE+       K    Q +E  + L        TT +
Sbjct: 4296 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4354

Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
               +++E + L     +  L+L+ +  E   L+ + D I       +  ++        F
Sbjct: 4355 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4407

Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571
             D  +     + + +    ++Q       L+ N+       D  +   +EL K     + 
Sbjct: 4408 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4461

Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
            LK+   EL   + +     K+ MQ +    E +     + Q R EA   QA+ F   + +
Sbjct: 4462 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4521

Query: 1628 TNEHLHKQTKT 1638
              E L +  +T
Sbjct: 4522 LLEWLAEAEQT 4532



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 3822 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 3881

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 3882 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 3928

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 3929 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 3985

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 3986 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4019

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4020 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4077

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4078 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4135

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4136 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4190

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4191 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4236

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4237 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4290

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4291 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4350

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4351 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4409

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4410 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4462

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4463 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4519

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++
Sbjct: 4520 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4569



 Score = 40.8 bits (94), Expect = 0.018
 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%)

Query: 282  VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339
            +Q L++W+  ++ QL  D+   G D+  V + ++NHK   + + +  SS++  K S  ++
Sbjct: 4411 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4469

Query: 340  -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392
                   ++ +K+   E   R E+  A  ++     E  L     F S     L WL E 
Sbjct: 4470 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4529

Query: 393  EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449
            E+    +     + +  R   D H E M++L++K   +     + + +L   HP  +T  
Sbjct: 4530 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4589

Query: 450  ---IEAYRAAMQTQWSWILQ 466
               I   RA  +   +W  Q
Sbjct: 4590 KHWITIIRARFEEVLAWAKQ 4609



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4096 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4155

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4156 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4215

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4216 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4265

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4266 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4296

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4297 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4356

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4357 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4414

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4415 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4463

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4464 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4515

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4516 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4572

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4573 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4628

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4629 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 4683

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 4684 TYKRRAAD 4691


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score = 2191 bits (5677), Expect = 0.0
 Identities = 1136/1255 (90%), Positives = 1171/1255 (93%), Gaps = 18/1255 (1%)

Query: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60
            MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML
Sbjct: 1    MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60

Query: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120
            QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI
Sbjct: 61   QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120

Query: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180
            DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL
Sbjct: 121  DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180

Query: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240
            NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN
Sbjct: 181  NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240

Query: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300
            FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE
Sbjct: 241  FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300

Query: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360
            WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK
Sbjct: 301  WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360

Query: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
            LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR
Sbjct: 361  LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420

Query: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
            ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA
Sbjct: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480

Query: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540
            YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN
Sbjct: 481  YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540

Query: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
            LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS
Sbjct: 541  LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660
            PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660

Query: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720
            DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ
Sbjct: 661  DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720

Query: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780
            YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI
Sbjct: 721  YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
            TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
Sbjct: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
            YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
Sbjct: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
            QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
            GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
Sbjct: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
            KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080

Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LENSKLT 1137
            YTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L++++  
Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140

Query: 1138 GK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNVEDISL 1184
            GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + +++ S 
Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQE-SY 1199

Query: 1185 QKIRAESEAKQYRRELETIVREKEAAERELE-RVRQLTIEAEAKRAAVEENLLNF 1238
              + +ES  +    +    V+ +E  ++ +   + Q T E  +   AV   L+++
Sbjct: 1200 NLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDY 1254



 Score =  112 bits (281), Expect = 4e-24
 Identities = 210/1066 (19%), Positives = 412/1066 (38%), Gaps = 216/1066 (20%)

Query: 1650 EEDLAKSQNLVSEFKQKCDQQNII----IQNTKKEV---RNLNAELNASKEEKRRGEQKV 1702
            ++ L+  Q+   +F +   +  +     I   +KEV   +    EL  S E + + E   
Sbjct: 680  QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739

Query: 1703 QLQQAQVQELNNRLKKVQD-------------ELH---LKTIEEQMTHRKMVLFQEESGK 1746
             L  ++V+ +  RL+  +D             +LH    +  E++   +++   +++ G 
Sbjct: 740  NLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGT 799

Query: 1747 FKQSAEEF-------------RKKMEKLMES--KVITENDISGIRLDFVSLQQENSRAQE 1791
                 EEF             R ++  ++++  +V + +     +L  V+L  +N++A E
Sbjct: 800  ITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAE 859

Query: 1792 ------NAKLCE--------TNIKELERQLQQYREQMQQGQ---HMEANHYQKCQKLEDE 1834
                    KLCE         NI+ L   L+Q+R ++ + +   H   +  QK + + DE
Sbjct: 860  ALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 919

Query: 1835 LIAQKRE----VENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQ 1890
            +    +E     +  K+K DQ ++  ++  V +   ++            D E   K  +
Sbjct: 920  MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLR------------DLEGIGKSLK 967

Query: 1891 HSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIP------KEVQFQPPGA 1944
            +      R+T H       PL  W Q+ +  + K Q    E          + +      
Sbjct: 968  YY-----RDTYH-------PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015

Query: 1945 PLEKEKSQQC--YSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPV--RYQ 2000
             +++ K  +C  Y+E +S T  + ++       +    +   ++ + + +S   +   + 
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075

Query: 2001 DNACEME-LVKVLTP-LEIAKNKQYDMHTEVTTLKQEKNP-VPSAEEWMLEGCRASGGLK 2057
            D       LV ++T  ++ A +    +  E  +L++EK   V  A+E        S  LK
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135

Query: 2058 KGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRL 2117
              +  K G  P + Q    +   + ++       L   +   QL  AK  D  T E+   
Sbjct: 1136 DAE--KAGKPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKHGDKMTDEERNE 1187

Query: 2118 GLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
              K V+ +Q++ N           L+ ES K+     ++ +  + +K+            
Sbjct: 1188 LEKQVKTLQESYNL----------LFSESLKQLQESQTSGDVKVEEKL------------ 1225

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSVFQAMENRMLD 2237
                           D V+ G +D                   + + LSVFQA+   ++D
Sbjct: 1226 ---------------DKVIAGTIDQT-----------------TGEVLSVFQAVLRGLID 1253

Query: 2238 RQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNN 2297
               G  +LE Q+   G+I P        + A   GL++  IL  L E S           
Sbjct: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKA--------- 1304

Query: 2298 KQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
            K+ +  +    + V D  +Q  +       +  + +      S+V   TG +LT+ +AFQ
Sbjct: 1305 KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTG---SLVIPATGEQLTLQKAFQ 1361

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL- 2416
            +NL+  +++ ++  +Q   K+             L D  T    ++ + +++ T+ +   
Sbjct: 1362 QNLVSSALFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTLQENTG 1408

Query: 2417 -----VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLV 2471
                 V+  + G ITL                             G  IS+L+A+   L+
Sbjct: 1409 MWLLPVRPQEGGRITLK---------------------------CGRNISILRAAHEGLI 1441

Query: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531
            DR T  R L AQ+ +GG+I+  +G++  V EA+  G++D   A  +   ++   GI    
Sbjct: 1442 DRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSN 1501

Query: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591
              K ++V EAV  ++I     +  LE Q    GLI P          +LQ  +I   +A 
Sbjct: 1502 PAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAY 1561

Query: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEP 2637
            K+ + +  +  +  P++ + +    A +    D +T   L  ++ P
Sbjct: 1562 KILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLP 1607



 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 253/1280 (19%), Positives = 504/1280 (39%), Gaps = 225/1280 (17%)

Query: 1140 ISELERMVAELKKQKSRVE--EELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYR 1197
            + +L   V E++ Q  R E   +LP V    EN  +   R +E                 
Sbjct: 282  VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENH-KNVHRAIE----------------- 323

Query: 1198 RELETIVREKEAAERELERVRQLTIEAEAKRAAVE-ENLLNFRNQLEENTFTRRTLEDHL 1256
             E E+ ++E + +E ++    +LT   +  R   +   LLN     E +  T        
Sbjct: 324  -EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 382

Query: 1257 KRKDLSLNDLEQQK-----NKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKE 1311
              + + LN+ E+++     ++    + RK+D   EL++ + Q E+++   +++AE+ L E
Sbjct: 383  TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 442

Query: 1312 KQ--KIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVD 1369
                ++ +EA R   + Q++     L +C   +          +  +D ++A +  + + 
Sbjct: 443  NHPARLTIEAYRAAMQTQWSW---ILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLK 499

Query: 1370 ELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN-----NTLRCLKLEL 1424
            +  A  RK   D     ++L  L  E  S EEK  LL+ K    N      T+  LK   
Sbjct: 500  D--AIQRKYSCDRSSSIHKLEDLVQE--SMEEKEELLQYKSTIANLMGKAKTIIQLK--- 552

Query: 1425 ERKDQAEKGYSQQLREL--GRQLNQTTGKAEEAM-------------------------- 1456
             R        S  ++ +   RQ+  T  K +E +                          
Sbjct: 553  PRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC 612

Query: 1457 -------QEASDL-KKIKRNYQ--LELESLNHEKGK-------LQREVDRITRAHAVAEK 1499
                   +EA DL  +I++ YQ  L L   +H   K       L  E+DRI  ++  + K
Sbjct: 613  FTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIK 672

Query: 1500 ------------NIQ---------HLNSQIHSFRDEKELER-LQICQRKSDHLKEQFEKS 1537
                        N+Q            SQ+ S  D  +LE+ + +C++    L +  E+ 
Sbjct: 673  TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAERE 732

Query: 1538 HEQ---------LLQNIKAEKENNDK--IQRLNEELEKSNECAEMLKQKVEELTRQNNET 1586
             ++          ++NI+   EN +   I+++   LE+ +     L + V  +T Q    
Sbjct: 733  EQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD-----LHESVFRITEQ---- 783

Query: 1587 KLMMQRIQAESENIVLEKQTIQQRCEALKIQADG------FKDQLRSTNEHLHKQTKTEQ 1640
                ++++ E E +  +  TI  +CE    QA         + +L    +++++      
Sbjct: 784  ----EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 839

Query: 1641 DFQRKIKCLEEDLAKSQ---NLVSEFKQK-CDQQNIIIQNTKKEVRNLNAELNASKEEKR 1696
             +  K+K +   L  +Q    LV  ++ K C+++ +I    K  + NL   ++  K+ + 
Sbjct: 840  TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIAD--KNNIENL---ISTLKQWRS 894

Query: 1697 RGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRK 1756
              ++K Q+  A   EL  + K + DE+  KT            ++E    F    E+  +
Sbjct: 895  EVDEKRQVFHALEDEL-QKAKAISDEM-FKT------------YKERDLDFDWHKEKADQ 940

Query: 1757 KMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816
             +E+     V  +N +     D   + +     ++     +  I+++E   ++ +E   +
Sbjct: 941  LVERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 996

Query: 1817 GQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQ---QIKEHEHQLVLLQCEI--QKKS 1871
                 A    + + L  E+  ++ +++  ++  +Q    +K++E Q +  +  +  Q+KS
Sbjct: 997  NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1056

Query: 1872 TAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPR------SPLLRWTQEPQPLEE-- 1923
              K    +   ++ ++E     +L +R T  +    +        L R  +E + LEE  
Sbjct: 1057 PVKRRRMQSSADLIIQEFM---DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK 1113

Query: 1924 -----------KWQHRVVEQIPKEVQFQPPGAPLEKEK-SQQCYSEYFSQTSTELQITFD 1971
                       KW   + + +    +   P  P  K+K S +  S    Q S  LQ    
Sbjct: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKP--PFSKQKISSEEISTKKEQLSEALQ---- 1167

Query: 1972 ETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTE--- 2028
             T  +      +K+ D+  N     V+    +  +   + L  L+ ++    D+  E   
Sbjct: 1168 -TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKL 1225

Query: 2029 ----VTTLKQEKNPVPSAEEWMLEGC---RASGGLKKGDFLKKGL-EPETFQNFDGDHAC 2080
                  T+ Q    V S  + +L G         L +   +  GL  PE  + FD   A 
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285

Query: 2081 S--VRDDEFKFQGLRHTVTARQLVE-AKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKAT 2137
            S  + D++   Q L+    A++++  A    +  ++ L   + T     K L   L    
Sbjct: 1286 SHGLIDEQILCQ-LKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILL---- 1340

Query: 2138 SIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLK 2197
            S   L + +T E+++   A ++ ++   +    LE Q     +IDP + +  S+ D V +
Sbjct: 1341 STGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQR 1400

Query: 2198 GVVDPEFRIRLLEAEKAAVG--YSYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVI 2255
              +     + LL       G       + +S+ +A    ++DR+    +L AQ+ SGG+I
Sbjct: 1401 STLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLI 1460

Query: 2256 DPVRGIRVPPEIALQQGLLN 2275
            +   G R+  E A+++G+++
Sbjct: 1461 NSNSGQRMTVEEAVREGVID 1480



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 152/889 (17%), Positives = 342/889 (38%), Gaps = 136/889 (15%)

Query: 630  EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 688
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446

Query: 689  RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 748
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490

Query: 749  IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 808
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549

Query: 809  SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604

Query: 859  EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 914
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664

Query: 915  AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 970
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719

Query: 971  DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1029
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761

Query: 1030 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMD---------- 1076
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF            
Sbjct: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819

Query: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKL 1136
            LR+    ++  M Q    +   + +L+   +   K T    A   L++  +  + E   +
Sbjct: 820  LRSELNVVLQNMNQVYSMSSTYIDKLKTVNLV-LKNTQ---AAEALVKLYETKLCEEEAV 875

Query: 1137 TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQY 1196
                + +E +++ LK+ +S V+E+  +V  A E+EL+K           K  ++   K Y
Sbjct: 876  IADKNNIENLISTLKQWRSEVDEKR-QVFHALEDELQKA----------KAISDEMFKTY 924

Query: 1197 RRELETIVREKEAAERELERVRQLTIEAEAKRAAVE---ENLLNFRNQ-------LEENT 1246
            +         KE A++ +ER + + ++ + +   +E   ++L  +R+        +++  
Sbjct: 925  KERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE 984

Query: 1247 FTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQME---KDLAFQKQ 1303
             T+R ++++      +L     Q+  L+ E+  K+   +E  K  +Q     KD   Q  
Sbjct: 985  TTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTM 1044

Query: 1304 VAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEE 1363
                 +  +QK  ++ RR  +      +E       +   T   A+  L  ++ K   + 
Sbjct: 1045 TYRAMVDSQQKSPVKRRRMQSSADLIIQEF------MDLRTRYTALVTLMTQYIKFAGDS 1098

Query: 1364 LKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLE 1423
            LK+                  L  E  +L+ EK    EKA+ L+  +   + TL+  +  
Sbjct: 1099 LKR------------------LEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140

Query: 1424 LERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLE 1472
             +     +K  S+++     QL++     +  + +  D    +   +LE
Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELE 1189



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 203/1029 (19%), Positives = 397/1029 (38%), Gaps = 178/1029 (17%)

Query: 705  GSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN---IRL-------RLE 754
            GSD+  +E  +   K  ++ +      EE E S+    ISE++    ++L       RLE
Sbjct: 302  GSDLPSVESHLENHKNVHRAI------EEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355

Query: 755  NCEDRLIRQIRTPLER-DDLHESVFRITEQ-----EKLKKELERLKDDLGTITNKCEEFF 808
            +   +L+   R      D LH  V R T +     EK ++E+     +  T   + +++ 
Sbjct: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415

Query: 809  SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 868
            ++         L  EL+   +N+  V  ++   + +     L ++  +AA      +  +
Sbjct: 416  AE---------LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 466

Query: 869  LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
            LC+      +++  EN  +   ++ ++  E       L+D +Q+ K   D     +K  D
Sbjct: 467  LCQ----CVEQHIKEN--TAYFEFFNDAKEATDYLRNLKDAIQR-KYSCDRSSSIHKLED 519

Query: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
            L  +  +EK + L         Q  + + +L G  K+                       
Sbjct: 520  LVQESMEEKEELL---------QYKSTIANLMGKAKT----------------------- 547

Query: 989  KIQENQPENSKT-LATQLNQQKML-VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
             I + +P NS   L T +  + +    +IE+   K DEC      + A  K   +     
Sbjct: 548  -IIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK--VISPTGN 604

Query: 1047 RAMVDSQQKS-PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK--FAGDSLKRLE 1103
             AMV S   + P   +     A+ I Q++ ++ T +      M   +   +  + + R+ 
Sbjct: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664

Query: 1104 EEEIKRCKET--SEHGAYSDLLQRQKATVLENSKLT-----GKISELERMV-------AE 1149
               +   K     EH      LQ +    LE+S+ +       I++LE+ V        E
Sbjct: 665  ASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE 724

Query: 1150 LKKQKSRVEEE--LPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREK 1207
            L K   R E+E  +  +  +    +R +  N ED  +++IR   E       +  I  E+
Sbjct: 725  LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRIT-EQ 783

Query: 1208 EAAERELERVRQ----LTIEAEA--KRAAVEENLLNFRNQLE-------ENTFTRRTLED 1254
            E  ++ELER++     +T + E    +AA   ++   R++L        +      T  D
Sbjct: 784  EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843

Query: 1255 HLKRKDLSLNDLEQQK-------NKLMEE--LRRKRDNEEELLKLIKQMEKDLAFQKQVA 1305
             LK  +L L + +  +        KL EE  +   ++N E L+  +KQ   ++  ++QV 
Sbjct: 844  KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 903

Query: 1306 EKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELK 1365
                 E QK    A+    E+  T +E  L                   +  K+KA++L 
Sbjct: 904  HALEDELQK----AKAISDEMFKTYKERDLDF-----------------DWHKEKADQL- 941

Query: 1366 QQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELE 1425
              V+     + + +  +R+L     +L+  + +       L D + +   T R ++   E
Sbjct: 942  --VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHP----LDDWIQQVETTQRKIQ---E 992

Query: 1426 RKDQAEKGYSQQLRE---LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGK 1482
             + +  K  + QL +   L  ++     K +E  + A       ++Y+L+  +       
Sbjct: 993  NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDS 1052

Query: 1483 LQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLL 1542
             Q+   +  R  + A+  IQ        F D +      +       L  Q+ K     L
Sbjct: 1053 QQKSPVKRRRMQSSADLIIQE-------FMDLRTRYTALVT------LMTQYIKFAGDSL 1099

Query: 1543 QNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVL 1602
            + ++ E+++ ++ ++  E +EK+ E  + +    + L       K    + +  SE I  
Sbjct: 1100 KRLEEEEKSLEEEKK--EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST 1157

Query: 1603 EKQTIQQRCEALKI----QADGFKDQLRSTNEHLHKQTKTEQD-----FQRKIKCLEEDL 1653
            +K+ + +  + +++      D   D+ R+    L KQ KT Q+     F   +K L+E  
Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERN---ELEKQVKTLQESYNLLFSESLKQLQESQ 1214

Query: 1654 AKSQNLVSE 1662
                  V E
Sbjct: 1215 TSGDVKVEE 1223


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 2124 bits (5504), Expect = 0.0
 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 411  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 470

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 471  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 530

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 531  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 590

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 591  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 650

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 651  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 710

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 711  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 770

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 771  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 830

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 831  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 890

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 891  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 950

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 951  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1010

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 1011 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1070

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1071 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1130

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1131 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1190

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1250

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1251 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1310

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1311 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1370

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1371 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1430

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L+
Sbjct: 1431 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1490

Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179
            +++  GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + +
Sbjct: 1491 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1550

Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203
            +                     D+ +++       ++Y+ +L+ I               
Sbjct: 1551 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1610

Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248
                       +++ ++ + EL++  Q + +A A+     EN L       +Q ++    
Sbjct: 1611 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1670

Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308
            ++  E  +K + L+L   EQ K +L + +      E E +  +KQ+E+     K   E  
Sbjct: 1671 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1725

Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359
            L     ++ ++ R  T+ +    +N        Q    ++  G         L+ + D Q
Sbjct: 1726 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1781

Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410
                 E L QQ  ++ A + K     + +     + Q  LEK     S EEK +L K+ +
Sbjct: 1782 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1840

Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463
             E          E E+K +      ++L +      +     +++ QE  +L+       
Sbjct: 1841 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1900

Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519
                K+KR      + ++H KG L+       R    A+   +    ++ +    +E+  
Sbjct: 1901 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 1957

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567
                QRK DH  ++F   + +        K+  DK Q   +            E   S  
Sbjct: 1958 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2013

Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
             +E +    + L RQ  ETK +  +I   S+ + +EK         LK  A+   D   S
Sbjct: 2014 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2062

Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687
                 +   KT  D   +     EDL+KS N  +E  Q    +++ +Q+   E+ +    
Sbjct: 2063 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2118

Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730
            + +S +E+ +                  EQ +  +Q+ +  +N ++KK      ++T + 
Sbjct: 2119 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2173

Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790
                      ++ S +F +++ + ++ + K+ E K   E     +     +  +  ++A 
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2232

Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849
                +   ++ EL + +Q+   E ++  +H+E  H    +     L + K  V      +
Sbjct: 2233 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2292

Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907
             ++ KE E  +       +KK     C  + D F++ VK  +   + +++    + P+  
Sbjct: 2293 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2346

Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931
               L +  ++ + L+EKW  +  E
Sbjct: 2347 AEDLGKSLEDTKKLQEKWSLKTPE 2370



 Score = 98.6 bits (244), Expect = 7e-20
 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1880 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1939

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1940 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1999

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 2000 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2055

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2056 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2111

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2112 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2169

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2170 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2225

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2226 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2275

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2276 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2334

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2335 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2390

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2391 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2425

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2426 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2476

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2477 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2536

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2537 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2594

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050
                 +   L TQ  Q ++L+ E   ++ + ++     +   S   +D  L+ +    + 
Sbjct: 2595 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2654

Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105
               QK      ++    D I Q  +   T+Y +L+  ++  +     K +         +
Sbjct: 2655 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2713

Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162
             + +  ET++       +Q++K  +     L   +S L   E + AEL +Q   + +   
Sbjct: 2714 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2771

Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222
             V + AEN ++  Q            +  + +Q  R+ +  +  K   + E  +   ++ 
Sbjct: 2772 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2820

Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
            + +   + ++++    +    ++    +T+ +    ++L L     +K  L  +L   + 
Sbjct: 2821 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2877

Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342
            N +   K +K+ E  L   K+  EK LK K+++E      I + Q    E    + P   
Sbjct: 2878 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2933

Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389
              S   +  LQ+E D+     E L    + L           T  N+   Q +  +T +L
Sbjct: 2934 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2993

Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437
            ++ +    +  +K +  ++   E+   L+C K +L+  D    + YS           + 
Sbjct: 2994 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3053

Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492
            L+ L  Q++     A++ + EASD K    +  L++E++  E   L ++VD       T+
Sbjct: 3054 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3112

Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548
               +   +  I+ + SQ   F D  EL+ +    R ++ L++Q E  K+  + L+ + A 
Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3170

Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608
             +N +K  ++    E+++     +K+ +E L++Q N+   ++ R QA  E +   + TI 
Sbjct: 3171 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3223

Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665
            +R E    +   F   L+   EH        ++ Q  +    E + +  N+   F++   
Sbjct: 3224 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3275

Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
               +  QQ++      +IQ+  K    + L  +L+      +   +KV  + AQ+QE   
Sbjct: 3276 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3335

Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772
               + QD L         T   +   +  S +FK  ++  + +K +++L++ +  T   I
Sbjct: 3336 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3395

Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830
               G ++   +   +  +  +   L ++  + L  + +    Q++    +    ++  + 
Sbjct: 3396 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3455

Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857
            L + L   ++ + N +       K+++QI +H+
Sbjct: 3456 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3488



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3249

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3250 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3306 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3363

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3364 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3419

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E          TQ   
Sbjct: 3420 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3479

Query: 991  QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027
             E Q    K L             A  + Q   ++S  E   M QSK+D       E Q+
Sbjct: 3480 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539

Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071
             +   S  ++          + E++ M +   V       S Q    +    Q S   ++
Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3599

Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115
            QE + LR +    AL+  +    +  GD +  +++  E IK R K+ ++           
Sbjct: 3600 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3659

Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161
                    H  + +L   L + +  +L  E   L G + S+ +    ELKK+    +  L
Sbjct: 3660 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3719

Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221
              + E +   L        +  L+K+ AE + ++YR   +TI ++ E  +  + R +Q  
Sbjct: 3720 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3777

Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271
              A+A+ + +   E+ L++  +   E   T   L+       + L+ KD+ ++DL +  +
Sbjct: 3778 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3836

Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331
            K+M        +EEE   + K+++K L     +   Q+  ++ ++LE  + +    +   
Sbjct: 3837 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3889

Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390
            E   P    TQ+  S      L+ E  +Q+ EE  +Q+ EL A ++     M +   +L 
Sbjct: 3890 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3948

Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449
             L   +  S ++  +  D L  +    ++   + L+        +  ++ ++   L +  
Sbjct: 3949 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4008

Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493
             +  +    +++++KIK      +N  +++E L   +E  K + E         D+   A
Sbjct: 4009 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4068

Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551
             AV +K   +  +   IH+  +E+E + L + +     L E+F   H  L+  I   K+ 
Sbjct: 4069 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4120

Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603
             D I+ L +       +++  E AE ++++++ L  + +    L  + I A  E +  + 
Sbjct: 4121 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4180

Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650
            K++I +   A       +KD++    E +    + +   Q               +  + 
Sbjct: 4181 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4240

Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703
             DL   +  + E KQ   +     Q  + E  N  AEL   K  +   +  VQ       
Sbjct: 4241 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4298

Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754
             +  +  + + NR  K++  L         L  +   +TH + +L +++       A E 
Sbjct: 4299 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4358

Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808
                  ++++ V+           +G  L   S  +E S  Q   ++     + +  + +
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418

Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
            Q ++Q+          + + + L+  L   +R +  L  K    + E   + + +  E+ 
Sbjct: 4419 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4476

Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928
                AK+ T+K               L  +    L   P+S      Q+   L+EKW+  
Sbjct: 4477 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4522

Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968
              +   ++ + +      +E   S Q +  + +Q    L +
Sbjct: 4523 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4563



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2684 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2740

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2741 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2800

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++          K I+
Sbjct: 2801 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2851

Query: 918  DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976
            +      K +  +    + + + +   W   + Q+  R   L E + K+LK Y++    L
Sbjct: 2852 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2910

Query: 977  DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017
              WI + +    +I+        EN     K+L  +++Q              L+S  E+
Sbjct: 2911 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2970

Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070
             K+   DE +   ++          K + L+ MT +   + Q+ S   +R++Q + + L 
Sbjct: 2971 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3029

Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124
            I + +  +      +T++       Q +K   D  KRL ++ +    E S+    SD+L 
Sbjct: 3030 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3086

Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170
            + +    E+S L+ ++ E               +  + E+  Q +  ++EL  +     +
Sbjct: 3087 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3146

Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229
             E  ++Q+      L+K+ A   +     +   ++   E    +L  +++  +EA +K+ 
Sbjct: 3147 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3205

Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
                +    R +  E T  +R  E + K K+ S   +  QK +  EE +     E E + 
Sbjct: 3206 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3261

Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349
              +Q+     FQK+  E    ++Q +                 N L    I  A    + 
Sbjct: 3262 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3302

Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396
             GL+ + D          K+ A+   Q  + L    R  +     L++ ++  +L   +K
Sbjct: 3303 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3362

Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442
              S E         + +LL+  LD+  +T+  +K E E+     + A+K    +QL  L 
Sbjct: 3363 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3422

Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489
             +      KAE   ++   +  + + +   LE LN      EK        G    +++ 
Sbjct: 3423 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3482

Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537
                H   E +I + N  +H            S R++K++ + ++   +  +++ Q EKS
Sbjct: 3483 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3541

Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591
            H   +LLQ     A+    D+++ +N   E  ++ +++  Q    E L +Q +E +++ +
Sbjct: 3542 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3601

Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646
             I    +N+    Q +    E LK Q  G      +D+L +        TK   D     
Sbjct: 3602 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3654

Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705
            K LE+ L  ++ L S  ++ C     + ++    E + L  E  AS+ + R  E K + +
Sbjct: 3655 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3713

Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761
              +   L + L +V   L L+ +  +       +  E++ +++  ++   +K+E++    
Sbjct: 3714 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3770

Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810
                        E   ITE +   + L  + L+Q+ + AQ   ++ +T   E+ R     
Sbjct: 3771 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3828

Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             + ++ G  +                  + E +++K+K+D+ +K ++
Sbjct: 3829 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3862



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3544 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3603

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3604 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3656

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3657 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3711

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3712 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3755

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D++  + +  + +  ++ M   +  L+   T A L +
Sbjct: 3756 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3813

Query: 543  GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3814 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3866

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3867 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3916

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3917 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3969

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3970 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4026

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 4027 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4086

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4087 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4133

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4191

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4248

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4249 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4308

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113
            + R+     A L + +F        A +T    L+++     GD  K +E E  K     
Sbjct: 4309 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4362

Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
              H   +D+L  Q +TV   +K    + E     +   ++ S ++ +L  + +  +N L 
Sbjct: 4363 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4415

Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222
            K ++  + +      A  +AK +  E+E + +     ER L               QL +
Sbjct: 4416 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4471

Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
              E   AA E     +++ +++      R  +      D  +N+L+++   +  +L  ++
Sbjct: 4472 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4530

Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337
               EE L L  +     +D       AE+ L    +  L     + +I ++    N +  
Sbjct: 4531 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4590

Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
                     +  T L+    KQ    +K  +  + +   K  Q + E    L+  +    
Sbjct: 4591 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4650

Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451
               E    L + L+E+  +L   +LE+       K    Q +E  + L        TT +
Sbjct: 4651 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4709

Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
               +++E + L     +  L+L+ +  E   L+ + D I       +  ++        F
Sbjct: 4710 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4762

Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571
             D  +     + + +    ++Q       L+ N+       D  +   +EL K     + 
Sbjct: 4763 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4816

Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
            LK+   EL   + +     K+ MQ +    E +     + Q R EA   QA+ F   + +
Sbjct: 4817 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4876

Query: 1628 TNEHLHKQTKT 1638
              E L +  +T
Sbjct: 4877 LLEWLAEAEQT 4887



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4177 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4236

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4237 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4283

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4284 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4340

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4341 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4374

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4375 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4432

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4433 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4490

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4491 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4545

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4546 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4591

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4592 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4645

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4646 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4705

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4706 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4764

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4765 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4817

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4818 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4874

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++
Sbjct: 4875 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4924



 Score = 40.8 bits (94), Expect = 0.018
 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%)

Query: 282  VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339
            +Q L++W+  ++ QL  D+   G D+  V + ++NHK   + + +  SS++  K S  ++
Sbjct: 4766 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4824

Query: 340  -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392
                   ++ +K+   E   R E+  A  ++     E  L     F S     L WL E 
Sbjct: 4825 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4884

Query: 393  EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449
            E+    +     + +  R   D H E M++L++K   +     + + +L   HP  +T  
Sbjct: 4885 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944

Query: 450  ---IEAYRAAMQTQWSWILQ 466
               I   RA  +   +W  Q
Sbjct: 4945 KHWITIIRARFEEVLAWAKQ 4964



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4451 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4510

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4571 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4620

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4621 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4651

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4712 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4769

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4770 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4818

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4819 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4870

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4871 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4927

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4928 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4983

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4984 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5038

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5039 TYKRRAAD 5046


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 2124 bits (5504), Expect = 0.0
 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 422  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 481

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 482  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 541

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 542  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 601

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 602  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 661

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 662  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 721

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 722  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 782  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 842  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 902  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 961

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 962  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1021

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L+
Sbjct: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501

Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179
            +++  GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + +
Sbjct: 1502 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1561

Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203
            +                     D+ +++       ++Y+ +L+ I               
Sbjct: 1562 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1621

Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248
                       +++ ++ + EL++  Q + +A A+     EN L       +Q ++    
Sbjct: 1622 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1681

Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308
            ++  E  +K + L+L   EQ K +L + +      E E +  +KQ+E+     K   E  
Sbjct: 1682 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1736

Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359
            L     ++ ++ R  T+ +    +N        Q    ++  G         L+ + D Q
Sbjct: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1792

Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410
                 E L QQ  ++ A + K     + +     + Q  LEK     S EEK +L K+ +
Sbjct: 1793 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1851

Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463
             E          E E+K +      ++L +      +     +++ QE  +L+       
Sbjct: 1852 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1911

Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519
                K+KR      + ++H KG L+       R    A+   +    ++ +    +E+  
Sbjct: 1912 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 1968

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567
                QRK DH  ++F   + +        K+  DK Q   +            E   S  
Sbjct: 1969 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024

Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
             +E +    + L RQ  ETK +  +I   S+ + +EK         LK  A+   D   S
Sbjct: 2025 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2073

Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687
                 +   KT  D   +     EDL+KS N  +E  Q    +++ +Q+   E+ +    
Sbjct: 2074 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2129

Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730
            + +S +E+ +                  EQ +  +Q+ +  +N ++KK      ++T + 
Sbjct: 2130 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2184

Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790
                      ++ S +F +++ + ++ + K+ E K   E     +     +  +  ++A 
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2243

Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849
                +   ++ EL + +Q+   E ++  +H+E  H    +     L + K  V      +
Sbjct: 2244 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2303

Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907
             ++ KE E  +       +KK     C  + D F++ VK  +   + +++    + P+  
Sbjct: 2304 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2357

Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931
               L +  ++ + L+EKW  +  E
Sbjct: 2358 AEDLGKSLEDTKKLQEKWSLKTPE 2381



 Score = 98.6 bits (244), Expect = 7e-20
 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1891 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1950

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1951 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2010

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 2011 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2067 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2122

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2123 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2180

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2181 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2286

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2287 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2345

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2346 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2401

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2402 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2436

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2437 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2487

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2548 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2605

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050
                 +   L TQ  Q ++L+ E   ++ + ++     +   S   +D  L+ +    + 
Sbjct: 2606 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665

Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105
               QK      ++    D I Q  +   T+Y +L+  ++  +     K +         +
Sbjct: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2724

Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162
             + +  ET++       +Q++K  +     L   +S L   E + AEL +Q   + +   
Sbjct: 2725 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782

Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222
             V + AEN ++  Q            +  + +Q  R+ +  +  K   + E  +   ++ 
Sbjct: 2783 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2831

Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
            + +   + ++++    +    ++    +T+ +    ++L L     +K  L  +L   + 
Sbjct: 2832 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2888

Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342
            N +   K +K+ E  L   K+  EK LK K+++E      I + Q    E    + P   
Sbjct: 2889 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2944

Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389
              S   +  LQ+E D+     E L    + L           T  N+   Q +  +T +L
Sbjct: 2945 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 3004

Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437
            ++ +    +  +K +  ++   E+   L+C K +L+  D    + YS           + 
Sbjct: 3005 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3064

Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492
            L+ L  Q++     A++ + EASD K    +  L++E++  E   L ++VD       T+
Sbjct: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3123

Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548
               +   +  I+ + SQ   F D  EL+ +    R ++ L++Q E  K+  + L+ + A 
Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3181

Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608
             +N +K  ++    E+++     +K+ +E L++Q N+   ++ R QA  E +   + TI 
Sbjct: 3182 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3234

Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665
            +R E    +   F   L+   EH        ++ Q  +    E + +  N+   F++   
Sbjct: 3235 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3286

Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
               +  QQ++      +IQ+  K    + L  +L+      +   +KV  + AQ+QE   
Sbjct: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3346

Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772
               + QD L         T   +   +  S +FK  ++  + +K +++L++ +  T   I
Sbjct: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406

Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830
               G ++   +   +  +  +   L ++  + L  + +    Q++    +    ++  + 
Sbjct: 3407 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3466

Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857
            L + L   ++ + N +       K+++QI +H+
Sbjct: 3467 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3499



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3260

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3261 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3374

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3375 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E          TQ   
Sbjct: 3431 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490

Query: 991  QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027
             E Q    K L             A  + Q   ++S  E   M QSK+D       E Q+
Sbjct: 3491 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550

Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071
             +   S  ++          + E++ M +   V       S Q    +    Q S   ++
Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3610

Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115
            QE + LR +    AL+  +    +  GD +  +++  E IK R K+ ++           
Sbjct: 3611 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3670

Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161
                    H  + +L   L + +  +L  E   L G + S+ +    ELKK+    +  L
Sbjct: 3671 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3730

Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221
              + E +   L        +  L+K+ AE + ++YR   +TI ++ E  +  + R +Q  
Sbjct: 3731 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3788

Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271
              A+A+ + +   E+ L++  +   E   T   L+       + L+ KD+ ++DL +  +
Sbjct: 3789 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3847

Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331
            K+M        +EEE   + K+++K L     +   Q+  ++ ++LE  + +    +   
Sbjct: 3848 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3900

Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390
            E   P    TQ+  S      L+ E  +Q+ EE  +Q+ EL A ++     M +   +L 
Sbjct: 3901 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3959

Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449
             L   +  S ++  +  D L  +    ++   + L+        +  ++ ++   L +  
Sbjct: 3960 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4019

Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493
             +  +    +++++KIK      +N  +++E L   +E  K + E         D+   A
Sbjct: 4020 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4079

Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551
             AV +K   +  +   IH+  +E+E + L + +     L E+F   H  L+  I   K+ 
Sbjct: 4080 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4131

Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603
             D I+ L +       +++  E AE ++++++ L  + +    L  + I A  E +  + 
Sbjct: 4132 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4191

Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650
            K++I +   A       +KD++    E +    + +   Q               +  + 
Sbjct: 4192 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4251

Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703
             DL   +  + E KQ   +     Q  + E  N  AEL   K  +   +  VQ       
Sbjct: 4252 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309

Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754
             +  +  + + NR  K++  L         L  +   +TH + +L +++       A E 
Sbjct: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369

Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808
                  ++++ V+           +G  L   S  +E S  Q   ++     + +  + +
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429

Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
            Q ++Q+          + + + L+  L   +R +  L  K    + E   + + +  E+ 
Sbjct: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4487

Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928
                AK+ T+K               L  +    L   P+S      Q+   L+EKW+  
Sbjct: 4488 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4533

Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968
              +   ++ + +      +E   S Q +  + +Q    L +
Sbjct: 4534 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4574



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2695 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2751

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2752 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2811

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++          K I+
Sbjct: 2812 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2862

Query: 918  DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976
            +      K +  +    + + + +   W   + Q+  R   L E + K+LK Y++    L
Sbjct: 2863 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2921

Query: 977  DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017
              WI + +    +I+        EN     K+L  +++Q              L+S  E+
Sbjct: 2922 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2981

Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070
             K+   DE +   ++          K + L+ MT +   + Q+ S   +R++Q + + L 
Sbjct: 2982 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3040

Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124
            I + +  +      +T++       Q +K   D  KRL ++ +    E S+    SD+L 
Sbjct: 3041 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3097

Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170
            + +    E+S L+ ++ E               +  + E+  Q +  ++EL  +     +
Sbjct: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157

Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229
             E  ++Q+      L+K+ A   +     +   ++   E    +L  +++  +EA +K+ 
Sbjct: 3158 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3216

Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
                +    R +  E T  +R  E + K K+ S   +  QK +  EE +     E E + 
Sbjct: 3217 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3272

Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349
              +Q+     FQK+  E    ++Q +                 N L    I  A    + 
Sbjct: 3273 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3313

Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396
             GL+ + D          K+ A+   Q  + L    R  +     L++ ++  +L   +K
Sbjct: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373

Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442
              S E         + +LL+  LD+  +T+  +K E E+     + A+K    +QL  L 
Sbjct: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3433

Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489
             +      KAE   ++   +  + + +   LE LN      EK        G    +++ 
Sbjct: 3434 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3493

Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537
                H   E +I + N  +H            S R++K++ + ++   +  +++ Q EKS
Sbjct: 3494 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3552

Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591
            H   +LLQ     A+    D+++ +N   E  ++ +++  Q    E L +Q +E +++ +
Sbjct: 3553 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3612

Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646
             I    +N+    Q +    E LK Q  G      +D+L +        TK   D     
Sbjct: 3613 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3665

Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705
            K LE+ L  ++ L S  ++ C     + ++    E + L  E  AS+ + R  E K + +
Sbjct: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3724

Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761
              +   L + L +V   L L+ +  +       +  E++ +++  ++   +K+E++    
Sbjct: 3725 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781

Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810
                        E   ITE +   + L  + L+Q+ + AQ   ++ +T   E+ R     
Sbjct: 3782 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3839

Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             + ++ G  +                  + E +++K+K+D+ +K ++
Sbjct: 3840 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3873



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3555 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3615 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3667

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3668 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3722

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3723 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3766

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D++  + +  + +  ++ M   +  L+   T A L +
Sbjct: 3767 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3824

Query: 543  GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3825 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3877

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3878 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3927

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3928 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3980

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3981 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4037

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 4038 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4097

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4098 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4202

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4259

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4319

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113
            + R+     A L + +F        A +T    L+++     GD  K +E E  K     
Sbjct: 4320 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4373

Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
              H   +D+L  Q +TV   +K    + E     +   ++ S ++ +L  + +  +N L 
Sbjct: 4374 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4426

Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222
            K ++  + +      A  +AK +  E+E + +     ER L               QL +
Sbjct: 4427 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4482

Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
              E   AA E     +++ +++      R  +      D  +N+L+++   +  +L  ++
Sbjct: 4483 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4541

Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337
               EE L L  +     +D       AE+ L    +  L     + +I ++    N +  
Sbjct: 4542 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4601

Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
                     +  T L+    KQ    +K  +  + +   K  Q + E    L+  +    
Sbjct: 4602 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4661

Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451
               E    L + L+E+  +L   +LE+       K    Q +E  + L        TT +
Sbjct: 4662 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4720

Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
               +++E + L     +  L+L+ +  E   L+ + D I       +  ++        F
Sbjct: 4721 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4773

Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571
             D  +     + + +    ++Q       L+ N+       D  +   +EL K     + 
Sbjct: 4774 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4827

Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
            LK+   EL   + +     K+ MQ +    E +     + Q R EA   QA+ F   + +
Sbjct: 4828 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4887

Query: 1628 TNEHLHKQTKT 1638
              E L +  +T
Sbjct: 4888 LLEWLAEAEQT 4898



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4248 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4294

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4295 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4351

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4352 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4385

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4386 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4501

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4502 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4556

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4557 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4602

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4603 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4656

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4657 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4716

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4717 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4775

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4776 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4828

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4829 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4885

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++
Sbjct: 4886 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4935



 Score = 40.8 bits (94), Expect = 0.018
 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%)

Query: 282  VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339
            +Q L++W+  ++ QL  D+   G D+  V + ++NHK   + + +  SS++  K S  ++
Sbjct: 4777 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4835

Query: 340  -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392
                   ++ +K+   E   R E+  A  ++     E  L     F S     L WL E 
Sbjct: 4836 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4895

Query: 393  EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449
            E+    +     + +  R   D H E M++L++K   +     + + +L   HP  +T  
Sbjct: 4896 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955

Query: 450  ---IEAYRAAMQTQWSWILQ 466
               I   RA  +   +W  Q
Sbjct: 4956 KHWITIIRARFEEVLAWAKQ 4975



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4582 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4631

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4632 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4662

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4780

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4781 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4829

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4830 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4881

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4882 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4938

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4939 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4994

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4995 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5049

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5050 TYKRRAAD 5057


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 2124 bits (5504), Expect = 0.0
 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 560  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 619

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 620  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 679

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 680  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 739

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 740  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 799

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 800  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 859

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 860  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 919

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 920  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 979

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 980  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 1039

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 1040 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 1099

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 1100 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1159

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 1160 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1219

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1279

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1399

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1400 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1459

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1460 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1519

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1579

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L+
Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1639

Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179
            +++  GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + +
Sbjct: 1640 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1699

Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203
            +                     D+ +++       ++Y+ +L+ I               
Sbjct: 1700 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1759

Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248
                       +++ ++ + EL++  Q + +A A+     EN L       +Q ++    
Sbjct: 1760 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1819

Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308
            ++  E  +K + L+L   EQ K +L + +      E E +  +KQ+E+     K   E  
Sbjct: 1820 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1874

Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359
            L     ++ ++ R  T+ +    +N        Q    ++  G         L+ + D Q
Sbjct: 1875 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1930

Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410
                 E L QQ  ++ A + K     + +     + Q  LEK     S EEK +L K+ +
Sbjct: 1931 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1989

Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463
             E          E E+K +      ++L +      +     +++ QE  +L+       
Sbjct: 1990 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 2049

Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519
                K+KR      + ++H KG L+       R    A+   +    ++ +    +E+  
Sbjct: 2050 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 2106

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567
                QRK DH  ++F   + +        K+  DK Q   +            E   S  
Sbjct: 2107 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2162

Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
             +E +    + L RQ  ETK +  +I   S+ + +EK         LK  A+   D   S
Sbjct: 2163 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2211

Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687
                 +   KT  D   +     EDL+KS N  +E  Q    +++ +Q+   E+ +    
Sbjct: 2212 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2267

Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730
            + +S +E+ +                  EQ +  +Q+ +  +N ++KK      ++T + 
Sbjct: 2268 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2322

Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790
                      ++ S +F +++ + ++ + K+ E K   E     +     +  +  ++A 
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2381

Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849
                +   ++ EL + +Q+   E ++  +H+E  H    +     L + K  V      +
Sbjct: 2382 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2441

Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907
             ++ KE E  +       +KK     C  + D F++ VK  +   + +++    + P+  
Sbjct: 2442 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2495

Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931
               L +  ++ + L+EKW  +  E
Sbjct: 2496 AEDLGKSLEDTKKLQEKWSLKTPE 2519



 Score = 98.6 bits (244), Expect = 7e-20
 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 2029 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 2088

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 2089 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2148

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 2149 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2204

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2205 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2260

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2261 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2318

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2319 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2374

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2375 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2424

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2425 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2483

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2484 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2539

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2540 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2574

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2575 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2625

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2626 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2685

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2686 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2743

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050
                 +   L TQ  Q ++L+ E   ++ + ++     +   S   +D  L+ +    + 
Sbjct: 2744 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2803

Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105
               QK      ++    D I Q  +   T+Y +L+  ++  +     K +         +
Sbjct: 2804 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2862

Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162
             + +  ET++       +Q++K  +     L   +S L   E + AEL +Q   + +   
Sbjct: 2863 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2920

Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222
             V + AEN ++  Q            +  + +Q  R+ +  +  K   + E  +   ++ 
Sbjct: 2921 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2969

Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
            + +   + ++++    +    ++    +T+ +    ++L L     +K  L  +L   + 
Sbjct: 2970 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 3026

Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342
            N +   K +K+ E  L   K+  EK LK K+++E      I + Q    E    + P   
Sbjct: 3027 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 3082

Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389
              S   +  LQ+E D+     E L    + L           T  N+   Q +  +T +L
Sbjct: 3083 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 3142

Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437
            ++ +    +  +K +  ++   E+   L+C K +L+  D    + YS           + 
Sbjct: 3143 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3202

Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492
            L+ L  Q++     A++ + EASD K    +  L++E++  E   L ++VD       T+
Sbjct: 3203 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3261

Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548
               +   +  I+ + SQ   F D  EL+ +    R ++ L++Q E  K+  + L+ + A 
Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3319

Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608
             +N +K  ++    E+++     +K+ +E L++Q N+   ++ R QA  E +   + TI 
Sbjct: 3320 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3372

Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665
            +R E    +   F   L+   EH        ++ Q  +    E + +  N+   F++   
Sbjct: 3373 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3424

Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
               +  QQ++      +IQ+  K    + L  +L+      +   +KV  + AQ+QE   
Sbjct: 3425 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3484

Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772
               + QD L         T   +   +  S +FK  ++  + +K +++L++ +  T   I
Sbjct: 3485 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3544

Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830
               G ++   +   +  +  +   L ++  + L  + +    Q++    +    ++  + 
Sbjct: 3545 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3604

Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857
            L + L   ++ + N +       K+++QI +H+
Sbjct: 3605 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3637



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3398

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3399 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3455 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3512

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3513 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3568

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E          TQ   
Sbjct: 3569 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3628

Query: 991  QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027
             E Q    K L             A  + Q   ++S  E   M QSK+D       E Q+
Sbjct: 3629 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688

Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071
             +   S  ++          + E++ M +   V       S Q    +    Q S   ++
Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3748

Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115
            QE + LR +    AL+  +    +  GD +  +++  E IK R K+ ++           
Sbjct: 3749 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3808

Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161
                    H  + +L   L + +  +L  E   L G + S+ +    ELKK+    +  L
Sbjct: 3809 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3868

Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221
              + E +   L        +  L+K+ AE + ++YR   +TI ++ E  +  + R +Q  
Sbjct: 3869 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3926

Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271
              A+A+ + +   E+ L++  +   E   T   L+       + L+ KD+ ++DL +  +
Sbjct: 3927 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3985

Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331
            K+M        +EEE   + K+++K L     +   Q+  ++ ++LE  + +    +   
Sbjct: 3986 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 4038

Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390
            E   P    TQ+  S      L+ E  +Q+ EE  +Q+ EL A ++     M +   +L 
Sbjct: 4039 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 4097

Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449
             L   +  S ++  +  D L  +    ++   + L+        +  ++ ++   L +  
Sbjct: 4098 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4157

Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493
             +  +    +++++KIK      +N  +++E L   +E  K + E         D+   A
Sbjct: 4158 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4217

Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551
             AV +K   +  +   IH+  +E+E + L + +     L E+F   H  L+  I   K+ 
Sbjct: 4218 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4269

Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603
             D I+ L +       +++  E AE ++++++ L  + +    L  + I A  E +  + 
Sbjct: 4270 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4329

Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650
            K++I +   A       +KD++    E +    + +   Q               +  + 
Sbjct: 4330 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4389

Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703
             DL   +  + E KQ   +     Q  + E  N  AEL   K  +   +  VQ       
Sbjct: 4390 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4447

Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754
             +  +  + + NR  K++  L         L  +   +TH + +L +++       A E 
Sbjct: 4448 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4507

Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808
                  ++++ V+           +G  L   S  +E S  Q   ++     + +  + +
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567

Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
            Q ++Q+          + + + L+  L   +R +  L  K    + E   + + +  E+ 
Sbjct: 4568 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4625

Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928
                AK+ T+K               L  +    L   P+S      Q+   L+EKW+  
Sbjct: 4626 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4671

Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968
              +   ++ + +      +E   S Q +  + +Q    L +
Sbjct: 4672 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4712



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2833 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2889

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2890 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2949

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++          K I+
Sbjct: 2950 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 3000

Query: 918  DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976
            +      K +  +    + + + +   W   + Q+  R   L E + K+LK Y++    L
Sbjct: 3001 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 3059

Query: 977  DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017
              WI + +    +I+        EN     K+L  +++Q              L+S  E+
Sbjct: 3060 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 3119

Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070
             K+   DE +   ++          K + L+ MT +   + Q+ S   +R++Q + + L 
Sbjct: 3120 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3178

Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124
            I + +  +      +T++       Q +K   D  KRL ++ +    E S+    SD+L 
Sbjct: 3179 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3235

Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170
            + +    E+S L+ ++ E               +  + E+  Q +  ++EL  +     +
Sbjct: 3236 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3295

Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229
             E  ++Q+      L+K+ A   +     +   ++   E    +L  +++  +EA +K+ 
Sbjct: 3296 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3354

Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
                +    R +  E T  +R  E + K K+ S   +  QK +  EE +     E E + 
Sbjct: 3355 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3410

Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349
              +Q+     FQK+  E    ++Q +                 N L    I  A    + 
Sbjct: 3411 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3451

Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396
             GL+ + D          K+ A+   Q  + L    R  +     L++ ++  +L   +K
Sbjct: 3452 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3511

Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442
              S E         + +LL+  LD+  +T+  +K E E+     + A+K    +QL  L 
Sbjct: 3512 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3571

Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489
             +      KAE   ++   +  + + +   LE LN      EK        G    +++ 
Sbjct: 3572 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3631

Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537
                H   E +I + N  +H            S R++K++ + ++   +  +++ Q EKS
Sbjct: 3632 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3690

Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591
            H   +LLQ     A+    D+++ +N   E  ++ +++  Q    E L +Q +E +++ +
Sbjct: 3691 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3750

Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646
             I    +N+    Q +    E LK Q  G      +D+L +        TK   D     
Sbjct: 3751 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3803

Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705
            K LE+ L  ++ L S  ++ C     + ++    E + L  E  AS+ + R  E K + +
Sbjct: 3804 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3862

Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761
              +   L + L +V   L L+ +  +       +  E++ +++  ++   +K+E++    
Sbjct: 3863 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3919

Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810
                        E   ITE +   + L  + L+Q+ + AQ   ++ +T   E+ R     
Sbjct: 3920 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3977

Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             + ++ G  +                  + E +++K+K+D+ +K ++
Sbjct: 3978 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 4011



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3693 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3752

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3753 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3805

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3806 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3860

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3861 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3904

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D++  + +  + +  ++ M   +  L+   T A L +
Sbjct: 3905 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3962

Query: 543  GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3963 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 4015

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 4016 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 4065

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 4066 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 4118

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 4119 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4175

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 4176 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4235

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4236 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4282

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4340

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4397

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4398 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4457

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113
            + R+     A L + +F        A +T    L+++     GD  K +E E  K     
Sbjct: 4458 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4511

Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
              H   +D+L  Q +TV   +K    + E     +   ++ S ++ +L  + +  +N L 
Sbjct: 4512 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4564

Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222
            K ++  + +      A  +AK +  E+E + +     ER L               QL +
Sbjct: 4565 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4620

Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
              E   AA E     +++ +++      R  +      D  +N+L+++   +  +L  ++
Sbjct: 4621 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4679

Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337
               EE L L  +     +D       AE+ L    +  L     + +I ++    N +  
Sbjct: 4680 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4739

Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
                     +  T L+    KQ    +K  +  + +   K  Q + E    L+  +    
Sbjct: 4740 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4799

Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451
               E    L + L+E+  +L   +LE+       K    Q +E  + L        TT +
Sbjct: 4800 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4858

Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
               +++E + L     +  L+L+ +  E   L+ + D I       +  ++        F
Sbjct: 4859 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4911

Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571
             D  +     + + +    ++Q       L+ N+       D  +   +EL K     + 
Sbjct: 4912 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4965

Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
            LK+   EL   + +     K+ MQ +    E +     + Q R EA   QA+ F   + +
Sbjct: 4966 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 5025

Query: 1628 TNEHLHKQTKT 1638
              E L +  +T
Sbjct: 5026 LLEWLAEAEQT 5036



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4326 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4385

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4386 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4432

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4433 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4489

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4490 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4523

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4524 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4581

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4582 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4639

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4640 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4694

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4695 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4740

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4741 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4794

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4795 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4854

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4855 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4913

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4914 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4966

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4967 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 5023

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++
Sbjct: 5024 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 5073



 Score = 40.8 bits (94), Expect = 0.018
 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%)

Query: 282  VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339
            +Q L++W+  ++ QL  D+   G D+  V + ++NHK   + + +  SS++  K S  ++
Sbjct: 4915 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4973

Query: 340  -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392
                   ++ +K+   E   R E+  A  ++     E  L     F S     L WL E 
Sbjct: 4974 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 5033

Query: 393  EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449
            E+    +     + +  R   D H E M++L++K   +     + + +L   HP  +T  
Sbjct: 5034 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093

Query: 450  ---IEAYRAAMQTQWSWILQ 466
               I   RA  +   +W  Q
Sbjct: 5094 KHWITIIRARFEEVLAWAKQ 5113



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4600 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4659

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4720 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4769

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4770 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4800

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4918

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4919 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4967

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4968 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 5019

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 5020 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 5076

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 5077 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 5132

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 5133 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5187

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5188 TYKRRAAD 5195


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 2124 bits (5504), Expect = 0.0
 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 382  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 441

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 442  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 501

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 502  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 561

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 562  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 621

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 622  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 681

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 682  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 741

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 742  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 801

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 802  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 861

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 862  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 921

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 922  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 981

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 982  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1041

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101

Query: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1221

Query: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1222 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1281

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1282 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1341

Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L+
Sbjct: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461

Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179
            +++  GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + +
Sbjct: 1462 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1521

Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203
            +                     D+ +++       ++Y+ +L+ I               
Sbjct: 1522 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1581

Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248
                       +++ ++ + EL++  Q + +A A+     EN L       +Q ++    
Sbjct: 1582 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1641

Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308
            ++  E  +K + L+L   EQ K +L + +      E E +  +KQ+E+     K   E  
Sbjct: 1642 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1696

Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359
            L     ++ ++ R  T+ +    +N        Q    ++  G         L+ + D Q
Sbjct: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1752

Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410
                 E L QQ  ++ A + K     + +     + Q  LEK     S EEK +L K+ +
Sbjct: 1753 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1811

Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463
             E          E E+K +      ++L +      +     +++ QE  +L+       
Sbjct: 1812 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1871

Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519
                K+KR      + ++H KG L+       R    A+   +    ++ +    +E+  
Sbjct: 1872 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 1928

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567
                QRK DH  ++F   + +        K+  DK Q   +            E   S  
Sbjct: 1929 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984

Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
             +E +    + L RQ  ETK +  +I   S+ + +EK         LK  A+   D   S
Sbjct: 1985 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2033

Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687
                 +   KT  D   +     EDL+KS N  +E  Q    +++ +Q+   E+ +    
Sbjct: 2034 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2089

Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730
            + +S +E+ +                  EQ +  +Q+ +  +N ++KK      ++T + 
Sbjct: 2090 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2144

Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790
                      ++ S +F +++ + ++ + K+ E K   E     +     +  +  ++A 
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2203

Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849
                +   ++ EL + +Q+   E ++  +H+E  H    +     L + K  V      +
Sbjct: 2204 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2263

Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907
             ++ KE E  +       +KK     C  + D F++ VK  +   + +++    + P+  
Sbjct: 2264 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2317

Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931
               L +  ++ + L+EKW  +  E
Sbjct: 2318 AEDLGKSLEDTKKLQEKWSLKTPE 2341



 Score = 98.6 bits (244), Expect = 7e-20
 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%)

Query: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 1851 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1910

Query: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 1911 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1970

Query: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 1971 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026

Query: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 2027 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2082

Query: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 2083 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2140

Query: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 2141 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196

Query: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2246

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 2247 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2305

Query: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 2306 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2361

Query: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 2362 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2396

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 2397 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2447

Query: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507

Query: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 2508 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2565

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050
                 +   L TQ  Q ++L+ E   ++ + ++     +   S   +D  L+ +    + 
Sbjct: 2566 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2625

Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105
               QK      ++    D I Q  +   T+Y +L+  ++  +     K +         +
Sbjct: 2626 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2684

Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162
             + +  ET++       +Q++K  +     L   +S L   E + AEL +Q   + +   
Sbjct: 2685 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2742

Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222
             V + AEN ++  Q            +  + +Q  R+ +  +  K   + E  +   ++ 
Sbjct: 2743 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2791

Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
            + +   + ++++    +    ++    +T+ +    ++L L     +K  L  +L   + 
Sbjct: 2792 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2848

Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342
            N +   K +K+ E  L   K+  EK LK K+++E      I + Q    E    + P   
Sbjct: 2849 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2904

Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389
              S   +  LQ+E D+     E L    + L           T  N+   Q +  +T +L
Sbjct: 2905 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2964

Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437
            ++ +    +  +K +  ++   E+   L+C K +L+  D    + YS           + 
Sbjct: 2965 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3024

Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492
            L+ L  Q++     A++ + EASD K    +  L++E++  E   L ++VD       T+
Sbjct: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3083

Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548
               +   +  I+ + SQ   F D  EL+ +    R ++ L++Q E  K+  + L+ + A 
Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3141

Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608
             +N +K  ++    E+++     +K+ +E L++Q N+   ++ R QA  E +   + TI 
Sbjct: 3142 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3194

Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665
            +R E    +   F   L+   EH        ++ Q  +    E + +  N+   F++   
Sbjct: 3195 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3246

Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
               +  QQ++      +IQ+  K    + L  +L+      +   +KV  + AQ+QE   
Sbjct: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3306

Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772
               + QD L         T   +   +  S +FK  ++  + +K +++L++ +  T   I
Sbjct: 3307 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3366

Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830
               G ++   +   +  +  +   L ++  + L  + +    Q++    +    ++  + 
Sbjct: 3367 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3426

Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857
            L + L   ++ + N +       K+++QI +H+
Sbjct: 3427 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3459



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%)

Query: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3220

Query: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 3221 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3334

Query: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 3335 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E          TQ   
Sbjct: 3391 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450

Query: 991  QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027
             E Q    K L             A  + Q   ++S  E   M QSK+D       E Q+
Sbjct: 3451 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3510

Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071
             +   S  ++          + E++ M +   V       S Q    +    Q S   ++
Sbjct: 3511 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3570

Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115
            QE + LR +    AL+  +    +  GD +  +++  E IK R K+ ++           
Sbjct: 3571 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3630

Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161
                    H  + +L   L + +  +L  E   L G + S+ +    ELKK+    +  L
Sbjct: 3631 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3690

Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221
              + E +   L        +  L+K+ AE + ++YR   +TI ++ E  +  + R +Q  
Sbjct: 3691 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3748

Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271
              A+A+ + +   E+ L++  +   E   T   L+       + L+ KD+ ++DL +  +
Sbjct: 3749 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3807

Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331
            K+M        +EEE   + K+++K L     +   Q+  ++ ++LE  + +    +   
Sbjct: 3808 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3860

Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390
            E   P    TQ+  S      L+ E  +Q+ EE  +Q+ EL A ++     M +   +L 
Sbjct: 3861 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3919

Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449
             L   +  S ++  +  D L  +    ++   + L+        +  ++ ++   L +  
Sbjct: 3920 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3979

Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493
             +  +    +++++KIK      +N  +++E L   +E  K + E         D+   A
Sbjct: 3980 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4039

Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551
             AV +K   +  +   IH+  +E+E + L + +     L E+F   H  L+  I   K+ 
Sbjct: 4040 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4091

Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603
             D I+ L +       +++  E AE ++++++ L  + +    L  + I A  E +  + 
Sbjct: 4092 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4151

Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650
            K++I +   A       +KD++    E +    + +   Q               +  + 
Sbjct: 4152 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4211

Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703
             DL   +  + E KQ   +     Q  + E  N  AEL   K  +   +  VQ       
Sbjct: 4212 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269

Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754
             +  +  + + NR  K++  L         L  +   +TH + +L +++       A E 
Sbjct: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4329

Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808
                  ++++ V+           +G  L   S  +E S  Q   ++     + +  + +
Sbjct: 4330 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389

Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
            Q ++Q+          + + + L+  L   +R +  L  K    + E   + + +  E+ 
Sbjct: 4390 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4447

Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928
                AK+ T+K               L  +    L   P+S      Q+   L+EKW+  
Sbjct: 4448 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4493

Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968
              +   ++ + +      +E   S Q +  + +Q    L +
Sbjct: 4494 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4534



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%)

Query: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 2655 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2711

Query: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 2712 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2771

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++          K I+
Sbjct: 2772 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2822

Query: 918  DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976
            +      K +  +    + + + +   W   + Q+  R   L E + K+LK Y++    L
Sbjct: 2823 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2881

Query: 977  DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017
              WI + +    +I+        EN     K+L  +++Q              L+S  E+
Sbjct: 2882 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2941

Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070
             K+   DE +   ++          K + L+ MT +   + Q+ S   +R++Q + + L 
Sbjct: 2942 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3000

Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124
            I + +  +      +T++       Q +K   D  KRL ++ +    E S+    SD+L 
Sbjct: 3001 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3057

Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170
            + +    E+S L+ ++ E               +  + E+  Q +  ++EL  +     +
Sbjct: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117

Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229
             E  ++Q+      L+K+ A   +     +   ++   E    +L  +++  +EA +K+ 
Sbjct: 3118 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3176

Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
                +    R +  E T  +R  E + K K+ S   +  QK +  EE +     E E + 
Sbjct: 3177 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3232

Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349
              +Q+     FQK+  E    ++Q +                 N L    I  A    + 
Sbjct: 3233 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3273

Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396
             GL+ + D          K+ A+   Q  + L    R  +     L++ ++  +L   +K
Sbjct: 3274 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3333

Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442
              S E         + +LL+  LD+  +T+  +K E E+     + A+K    +QL  L 
Sbjct: 3334 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3393

Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489
             +      KAE   ++   +  + + +   LE LN      EK        G    +++ 
Sbjct: 3394 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3453

Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537
                H   E +I + N  +H            S R++K++ + ++   +  +++ Q EKS
Sbjct: 3454 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3512

Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591
            H   +LLQ     A+    D+++ +N   E  ++ +++  Q    E L +Q +E +++ +
Sbjct: 3513 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3572

Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646
             I    +N+    Q +    E LK Q  G      +D+L +        TK   D     
Sbjct: 3573 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3625

Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705
            K LE+ L  ++ L S  ++ C     + ++    E + L  E  AS+ + R  E K + +
Sbjct: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3684

Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761
              +   L + L +V   L L+ +  +       +  E++ +++  ++   +K+E++    
Sbjct: 3685 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3741

Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810
                        E   ITE +   + L  + L+Q+ + AQ   ++ +T   E+ R     
Sbjct: 3742 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3799

Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             + ++ G  +                  + E +++K+K+D+ +K ++
Sbjct: 3800 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3833



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 3515 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3574

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 3575 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3627

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 3628 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3682

Query: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 3683 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3726

Query: 486  NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542
            +D    T  +  +  AI R    D++  + +  + +  ++ M   +  L+   T A L +
Sbjct: 3727 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3784

Query: 543  GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 3785 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3837

Query: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 3838 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3887

Query: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 3888 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3940

Query: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 3941 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3997

Query: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 3998 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4057

Query: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 4058 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104

Query: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4162

Query: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4219

Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4279

Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113
            + R+     A L + +F        A +T    L+++     GD  K +E E  K     
Sbjct: 4280 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4333

Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
              H   +D+L  Q +TV   +K    + E     +   ++ S ++ +L  + +  +N L 
Sbjct: 4334 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4386

Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222
            K ++  + +      A  +AK +  E+E + +     ER L               QL +
Sbjct: 4387 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4442

Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
              E   AA E     +++ +++      R  +      D  +N+L+++   +  +L  ++
Sbjct: 4443 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4501

Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337
               EE L L  +     +D       AE+ L    +  L     + +I ++    N +  
Sbjct: 4502 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4561

Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
                     +  T L+    KQ    +K  +  + +   K  Q + E    L+  +    
Sbjct: 4562 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4621

Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451
               E    L + L+E+  +L   +LE+       K    Q +E  + L        TT +
Sbjct: 4622 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4680

Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
               +++E + L     +  L+L+ +  E   L+ + D I       +  ++        F
Sbjct: 4681 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4733

Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571
             D  +     + + +    ++Q       L+ N+       D  +   +EL K     + 
Sbjct: 4734 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4787

Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
            LK+   EL   + +     K+ MQ +    E +     + Q R EA   QA+ F   + +
Sbjct: 4788 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4847

Query: 1628 TNEHLHKQTKT 1638
              E L +  +T
Sbjct: 4848 LLEWLAEAEQT 4858



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%)

Query: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207

Query: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 4208 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4254

Query: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 4255 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4311

Query: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 4312 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4345

Query: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 4346 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403

Query: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4461

Query: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 4462 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4516

Query: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 4517 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4562

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 4563 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4616

Query: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 4617 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4676

Query: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 4677 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4735

Query: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 4736 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4788

Query: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 4789 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4845

Query: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++
Sbjct: 4846 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4895



 Score = 40.8 bits (94), Expect = 0.018
 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%)

Query: 282  VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339
            +Q L++W+  ++ QL  D+   G D+  V + ++NHK   + + +  SS++  K S  ++
Sbjct: 4737 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4795

Query: 340  -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392
                   ++ +K+   E   R E+  A  ++     E  L     F S     L WL E 
Sbjct: 4796 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4855

Query: 393  EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449
            E+    +     + +  R   D H E M++L++K   +     + + +L   HP  +T  
Sbjct: 4856 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915

Query: 450  ---IEAYRAAMQTQWSWILQ 466
               I   RA  +   +W  Q
Sbjct: 4916 KHWITIIRARFEEVLAWAKQ 4935



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421

Query: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 4422 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481

Query: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541

Query: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 4542 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4591

Query: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 4592 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4622

Query: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 4623 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682

Query: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 4683 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4740

Query: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 4741 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4789

Query: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 4790 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4841

Query: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 4842 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4898

Query: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 4899 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4954

Query: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 4955 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5009

Query: 923  TYKERDLD 930
            TYK R  D
Sbjct: 5010 TYKRRAAD 5017


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 1070 bits (2768), Expect = 0.0
 Identities = 680/1959 (34%), Positives = 1079/1959 (55%), Gaps = 240/1959 (12%)

Query: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
            RLE+L QIAN++Q  ++ CE+KL LA N LQ+D+  LESG   Q E+++  YI ECE L+
Sbjct: 425  RLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLI 484

Query: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
            RQ  +D+QIL D  YYQ ++L  RV +L+DE++ LR EC              T L   G
Sbjct: 485  RQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKG 530

Query: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
               SL     + + PS  +      T  L +  +T    S  TS                
Sbjct: 531  HFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS---------------- 563

Query: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
                                   RKP+ ++ L+  + +E+E N++FV +LL+WV+EMQ++
Sbjct: 564  ---------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMK 602

Query: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
            L+R EWG+DLPSVE  LE  +++H ++EE  SS+KEA++ E +M+     +YAE L +LE
Sbjct: 603  LERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE 662

Query: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
            +QY KL  TS  + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y 
Sbjct: 663  TQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYF 722

Query: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
            +EL  EL++K++  +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q  W+ QLC CVEQH+
Sbjct: 723  SELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHV 782

Query: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
            KENTAYF+FF+DA+E   +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q K
Sbjct: 783  KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842

Query: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
            S++A+L+G++KTI+QLKPR+ D  LK +I +KA+CDYRQIEITI K+DECVL +NS R K
Sbjct: 843  SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902

Query: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
            WKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+Y
Sbjct: 903  WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962

Query: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
            L  ++D ++  N+  +++  PGE  Q++ NLQ+ +EDFL+DS++S +FS +D  +LE+EV
Sbjct: 963  LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEV 1022

Query: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIR----TPLERD 771
              CK  +Q L+KS E E++EE+V  +YISE++NIRLRLE  E R++++I+    +  +RD
Sbjct: 1023 EACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRD 1082

Query: 772  DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831
               ++  RI EQE  +++L++L+ DL  ++ KC+ F  Q+ +SSSVPTLRSELN++++ M
Sbjct: 1083 AWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKM 1142

Query: 832  NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891
            + VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E   STL+ 
Sbjct: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH 1202

Query: 892  WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
            W S+V +K  VF  L++E+ KAK ++++M +   ER+LD + ++EK  QL ERW  V  Q
Sbjct: 1203 WLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQ 1262

Query: 952  IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
            ++ R  +LE I + L  YR  +  L  WI++    Q  ++  Q E+S+ L+ QL+QQ  L
Sbjct: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTAL 1322

Query: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071
             +EIE  Q+K+D+CQK+++QYS  VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I 
Sbjct: 1323 FAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAIT 1382

Query: 1072 QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH--------GAYSDLL 1123
            QEFMDLRTRYTALVTL TQ++K+  D+L+RLEEEE    +E  EH        G  S L 
Sbjct: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLA 1442

Query: 1124 Q--RQKAT-------------VLENSKLTGKISELERMVAE--------LKKQKSRVEEE 1160
            +  + KAT             +LE   L+ +++  +  V+E        L K   ++ E+
Sbjct: 1443 RNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEK 1502

Query: 1161 LPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL 1220
              K      N L K   ++ D S  +++       ++ E +T+ +++    ++LE +   
Sbjct: 1503 EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW 1562

Query: 1221 TIEAEAKRAAVE-ENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRR 1279
              +AE   A  +        + L++N    + L+D ++ +  S   + +     MEE + 
Sbjct: 1563 VGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQT 1622

Query: 1280 KRDNEE-----ELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENA 1334
            K    E     E L   K+  + L  + +VA+K+L+E     L+   + ++      EN 
Sbjct: 1623 KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 1682

Query: 1335 LPVCP---------------ITQATSCRAVTGLQQEHD-----------KQKAEELKQQV 1368
              +                 +T       ++G   E              Q  E+L +Q 
Sbjct: 1683 KKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQC 1742

Query: 1369 DELTAANRK---AEQDMRELTYELNAL--QLEKTSSEEKARLLKDKLDETN--------- 1414
            + + A +++    +Q+    T    A   Q     + E+ ++L+ KL E           
Sbjct: 1743 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 1802

Query: 1415 -----NTLRCLKLELERKDQAEKGYSQQLRELGRQL-NQTTGK----------------A 1452
                   ++ L+ EL++  Q  K +   L    ++L N   G                 +
Sbjct: 1803 SEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS 1862

Query: 1453 EEAMQEASDLKKIKRNYQ--LELESL-----------NHEKGKLQREVDRITRAHAVAEK 1499
            E+ +    DL+ +  + Q  L++E+            N  K KL+   +R T  H+   +
Sbjct: 1863 EDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR 1922

Query: 1500 NIQHLN---SQIHSFRDEKELER--LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDK 1554
               HLN    Q H F++  +  +  +Q C+   + L      S   +LQ      E    
Sbjct: 1923 LGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ------EQLAT 1976

Query: 1555 IQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENI-------------- 1600
             ++L EEL +     E L++   ++     E     + +Q  +++I              
Sbjct: 1977 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2036

Query: 1601 -------VLEKQTIQQRCEALKIQADGFKDQ---------LRS--TNEHLHKQTKTEQDF 1642
                   + + Q++Q+  E+L +Q+ G  +Q         L S    E L    K +QD 
Sbjct: 2037 SSLLQKAIAQSQSVQESLESL-LQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2095

Query: 1643 QRKIKCLEEDLAKSQNLVSEFKQKCDQQN-IIIQNTKKEVRNLNAELNASKEEKRRGEQK 1701
             R+   LE     ++ +V+ F +  D     ++Q    EV     +L   ++EK    +K
Sbjct: 2096 ARQKSSLE----ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151

Query: 1702 VQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL 1761
            +  Q    + L+ +L++  +             + +  F ++  +     E+ ++ ++ L
Sbjct: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211

Query: 1762 MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHME 1821
                ++TE    G  LD    Q      +++    +  +KE E+     +EQ+ + + + 
Sbjct: 2212 --EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKL- 2268

Query: 1822 ANHYQKCQK--------LEDELIAQ--KREVENLKQKMD 1850
               +QK  K         E  + A+  ++++E+LK  +D
Sbjct: 2269 VRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLD 2307



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 321/1712 (18%), Positives = 656/1712 (38%), Gaps = 307/1712 (17%)

Query: 268  LDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLP-----------SVESHLE 313
            L Q  T ++   KF+QD     +W++  + +L+    G   P           S    + 
Sbjct: 1807 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI 1866

Query: 314  NHKNVHRAIE-------EFESSLKEAKI-SEIQMTAPLKLTYAEKLHRLESQYAKLLNTS 365
            +HK   R +        + E+S KE K  SEI      KL  A +  R  + ++K     
Sbjct: 1867 SHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATE--RYTALHSKCTRLG 1924

Query: 366  RNQERHLDTLHNFVSRATNELIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAEL 418
             +    L   H F + A +   W+   E        + VA D       +A  K    +L
Sbjct: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK----QL 1980

Query: 419  MRELDQKEENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 477
              EL + +  ++ +Q++A  ++ +E  PA      +R   +T  S IL   Q +   + E
Sbjct: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPA----PDHRHVQETTDS-ILSHFQSLSYSLAE 2035

Query: 478  NTAYFEFF----NDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LEDLVQESMEEKEEL 531
             ++  +         +E+ + L      +++     + SS+    +++ +  +M+ K+++
Sbjct: 2036 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2095

Query: 532  LQYKS-------------------TIANLMGKAKTIIQ------LKPRNSDCPLKTSIPI 566
             + KS                   T A L GK   + Q      L+ +  +  LK  +P 
Sbjct: 2096 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2155

Query: 567  KAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLA 626
              + ++   ++  + +++  +              +GN+       F      ++  +L 
Sbjct: 2156 AEMFEHLSGKLQQFMENKSRML------------ASGNQPDQDITHFF-----QQIQELN 2198

Query: 627  NRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNL 686
              +E Q +N+ TL H              L+ E+     S+      +   +HQ  + NL
Sbjct: 2199 LEMEDQQENLDTLEH--------------LVTEL-----SSCGFALDLC--QHQDRVQNL 2237

Query: 687  QSRFEDFLEDSQESQVFSGSDITQLE---KEVNVCKQYYQEL----------LKSAEREE 733
            +  F +  +  +E +  + S   QL+   K V   +++ +E           + + E E+
Sbjct: 2238 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2297

Query: 734  QEESVYNLYISEVRNIRLRLE-NCE----DRLIRQIRTPLERD-------DLHESVFRIT 781
            Q E + +L         L  E NC+    + LI +I  P  +         +  SV  + 
Sbjct: 2298 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2357

Query: 782  EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841
                 K +L  ++ D+  +  K E+          +   +  L  +L  M +V+  +++ 
Sbjct: 2358 GYHTCK-DLTEIQCDMSDVNLKYEKL------GGVLHERQESLQAILNRMEEVHKEANSV 2410

Query: 842  IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901
            +  L++   VLK+  A  +  K         E V A   + +  ++ L+Q          
Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAELEQ---------- 2452

Query: 902  VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961
                   ++QK K     +  TY       +W K + ++L  RW+        R R LE 
Sbjct: 2453 ----NSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ-EELNSRWERATEVTVARQRQLEE 2507

Query: 962  IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021
                L  ++     L  W+ + E     +     + +  L  Q  Q + ++ E E ++ +
Sbjct: 2508 SASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM-LNAQKQQVQFMLKEFEARRQQ 2566

Query: 1022 MDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY 1081
             ++  + A+       D  L T   +  + S  +  V+     +S    I + +   T+Y
Sbjct: 2567 HEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQY 2626

Query: 1082 TALVTLMTQYIKFAGDSLK-----RLEEEEIKR-CKETSEHGAYSDLLQRQKATVLENSK 1135
              L+  +++ ++  G  L        + E +K+  +ETSE    SDL Q     V E   
Sbjct: 2627 QELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE--IRSDLEQLDHE-VKEAQT 2683

Query: 1136 LTGKISEL---ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESE 1192
            L  ++S L   + +  ELKK+   V   L  + + A + + + Q          + +  +
Sbjct: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQA--------ALASTQQ 2735

Query: 1193 AKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTL 1252
             +Q   EL T + +K++ +              AK   +   L   ++QL+EN   +++L
Sbjct: 2736 FQQMFDELRTWLDDKQSQQ--------------AKNCPISAKLERLQSQLQENEEFQKSL 2781

Query: 1253 EDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEK 1312
              H    ++ + +                   E LL  +   E          EK+  + 
Sbjct: 2782 NQHSGSYEVIVAE------------------GESLLLSVPPGE----------EKRTLQN 2813

Query: 1313 QKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELT 1372
            Q +EL+   +    +   R++ L  C                    QKA++ +  V++L 
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDC-------------------MQKAQKYQWHVEDLV 2854

Query: 1373 AANRKAEQDMRELTYELNALQLEKTSSEEKARL----LKDKLDETNNTLRCLKLELERKD 1428
                  +  M EL   L+ +QLE +    KA L     +  L E  N+   + +     D
Sbjct: 2855 PWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD 2914

Query: 1429 Q-----AEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKL 1483
            +      + G +Q +  +  +L   TG  EE  Q   + ++  +N + ++E   H     
Sbjct: 2915 EDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKH----- 2969

Query: 1484 QREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQ 1543
            Q E+     + A + KN++ L +Q          E LQ  + + D+L+   +        
Sbjct: 2970 QLEIFDALGSQACSNKNLEKLRAQ---------QEVLQALEPQVDYLRNFTQGL------ 3014

Query: 1544 NIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQ-RIQAESENIVL 1602
             ++   + +D  Q L++        AE+ +Q+  E+ ++ N   +MM+ +++   +    
Sbjct: 3015 -VEDAPDGSDASQLLHQ--------AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3065

Query: 1603 EKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSE 1662
             ++   Q  + L  + DG     R T + L  Q +  + F  KI  L+ D+  S+   +E
Sbjct: 3066 VREMFSQLAD-LDDELDGMGAIGRDT-DSLQSQIEDVRLFLNKIHVLKLDIEASE---AE 3120

Query: 1663 FKQKCDQQNII-IQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQD 1721
             +   +++  + +   K+E+  LN +     E  +  +++++L   +V++   +LK + D
Sbjct: 3121 CRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180

Query: 1722 ELHLKTIEEQM---THRKMVLFQEESGKFKQSAEEFRKKME-KLMESKVITENDISGIRL 1777
                    E +      ++ +  ++   FK   +E    ++ KL +   + +  I     
Sbjct: 3181 ATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3240

Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIA 1837
            D      E+   + NA+    N K++ +++ Q +E +         H  K Q   + L++
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLN-KKVAQRIAQLQEALL--------HCGKFQDALEPLLS 3291

Query: 1838 QKREVENLKQKMDQQIKEHEHQLVLLQCEIQK 1869
               + E L    +Q+    E+++V  Q + QK
Sbjct: 3292 WLADTEEL--IANQKPPSAEYKVVKAQIQEQK 3321



 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 291/1508 (19%), Positives = 577/1508 (38%), Gaps = 218/1508 (14%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD------------RTEWGSDLPSVESH 311
            K++LLDQ L+   +  +   ++LNW+ E++ +L               +    L   E  
Sbjct: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545

Query: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
            +   KNV +AI+  ++ LK+    E+       L   EKL  ++++YA +  TS    R 
Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEV-------LLIQEKLDGIKTRYADITVTSSKALRT 3598

Query: 372  LDTLHNFVSR--ATNELI--WLNEKEEE-EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
            L+      ++  +T E +  WL E EEE   +   S     I + +    EL +E+ +  
Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658

Query: 427  ENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWI--------------LQLCQCV 471
              + +V E++  LL L    AR  ++   +    Q+  +              +Q  Q  
Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718

Query: 472  EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
            EQ      A+         A   +R  +D    +    ++ SI    D+++   +  +EL
Sbjct: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI----DIIRHK-DSMDEL 3773

Query: 532  LQYKSTIANLMG-KAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANN 590
              ++S I    G + KT++Q K   ++  ++    I  +   R   +     +   +  N
Sbjct: 3774 FSHRSEIFGTCGEEQKTVLQEK---TESLIQQYEAISLLNSERYARL-----ERAQVLVN 3825

Query: 591  SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSV 650
                 ++ +SP   E    ++   +P P   A+D   ++ QQ + +  L        +S+
Sbjct: 3826 QFWETYEELSPWIEETR--ALIAQLPSP---AID-HEQLRQQQEEMRQL-------RESI 3872

Query: 651  VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
                  I+++ +I       +K + P E + V               +E    + +   Q
Sbjct: 3873 AEHKPHIDKLLKIG----PQLKELNPEEGEMV---------------EEKYQKAENMYAQ 3913

Query: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLER 770
            +++EV       Q  L   E   Q   +   +  ++  +   LEN   RL      P E 
Sbjct: 3914 IKEEVR------QRALALDEAVSQSTQITEFH-DKIEPMLETLENLSSRLRMPPLIPAEV 3966

Query: 771  DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVV 827
            D + E    I++ +    ELE+L+     +  + EE   ++  +    +   ++ +L+ +
Sbjct: 3967 DKIREC---ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4023

Query: 828  LQNMNQVYSMSS----TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883
            +     + + +      ++D L+       +  A    +K  +  + + E+   D + I+
Sbjct: 4024 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIK 4083

Query: 884  NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
              +   +  + E D        L +EL+  + +  ++     E +      ++  D++  
Sbjct: 4084 QQVEAAETIKEETD-------GLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNN 4134

Query: 944  RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTL 1001
             W+N++     RL  LE   ++   Y+DT   + DW+   + T  K+    P  +   T+
Sbjct: 4135 AWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL---DNTVIKLCTMPPVGTDLNTV 4191

Query: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAE-----QYSATVKDYELQTMT-YRAMVDSQQK 1055
              QLN+ K    E+  +Q +M++     E         T +D   + +T  + + ++  +
Sbjct: 4192 KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE 4251

Query: 1056 SPVKRRRMQSSADLIIQEFM----DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK 1111
                R+     A L + +F     +L +  T    L+      +GD  K +E E  K   
Sbjct: 4252 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDP-KVIEVELAK--- 4307

Query: 1112 ETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENE 1171
                H   +D+L  Q ATV   +K   ++ E     +      S +   L  + +  E+ 
Sbjct: 4308 ---HHVLKNDVLAHQ-ATVETVNKAGNELLE-----SSAGDDASSLRSRLEAMNQCWESV 4358

Query: 1172 LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAV 1231
            L+K +   + +         +A+ +  E+E  + E    E +L         A      +
Sbjct: 4359 LQKTEEREQQLQ----STLQQAQGFHSEIEDFLLELTRMESQL--------SASKPTGGL 4406

Query: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI 1291
             E     R QL+    T   L   LK K+ + N L   K +LM   R    +  +  + +
Sbjct: 4407 PETA---REQLD----THMELYSQLKAKEETYNQL-LDKGRLMLLSRDDSGSGSKTEQSV 4458

Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351
              +E+       V+ K  + K K+E EA    TE Q + +E    +    Q+ +  +   
Sbjct: 4459 ALLEQK---WHVVSSKMEERKSKLE-EALNLATEFQNSLQEFINWLTLAEQSLNIASPPS 4514

Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNAL--QLEKTSSEEKARLLKDK 1409
            L       + EE K   +E+ A         R+   EL+    QL+  S ++   L+K+ 
Sbjct: 4515 LILNTVLSQIEEHKVFANEVNA--------HRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566

Query: 1410 LDETNNTL-RCLKLELERKDQAE------KGYSQQLRELGRQLNQTTGKAEEAMQEASDL 1462
            L    +   + ++  +ER    +      K + +  ++L   L       +  ++ ++D 
Sbjct: 4567 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 4626

Query: 1463 KKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNI-----QHLNSQIHSFRDE--- 1514
             KIK       E      GK       I    A+ EK +     Q L++ +   RD+   
Sbjct: 4627 DKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDT 4686

Query: 1515 ---KELER-------LQICQRKSDHLK---EQFEKSHEQLLQNIKAEKENN------DKI 1555
               K +ER       L    +  D L+   +   K   QL ++     + +      D  
Sbjct: 4687 VCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAH 4746

Query: 1556 QRLNEELEKSNECAEMLKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRC 1611
            +   +EL K     ++LK+   EL   + +     K  +Q +    + +     + Q R 
Sbjct: 4747 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRL 4806

Query: 1612 EALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV---SEFKQKCD 1668
            E    QA+ F+D +    E L +  +T     R    L +D    Q+L+    EF +K +
Sbjct: 4807 EQALKQAEVFRDTVHMLLEWLSEAEQT----LRFRGALPDDTEALQSLIDTHKEFMKKVE 4862

Query: 1669 QQNIIIQN 1676
            ++ + + +
Sbjct: 4863 EKRVDVNS 4870



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 364/1945 (18%), Positives = 733/1945 (37%), Gaps = 293/1945 (15%)

Query: 242  SSGVEPNSLQTLKLMQIRKPL--LKSSLLD---QNLTEEEINMKFVQDLLNWVDEMQVQL 296
            + G  P +  ++   ++ K +  LKS L D   +    EEIN K    L N + E+    
Sbjct: 2279 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS-LENLIMEITAPD 2337

Query: 297  DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT-APLKLTYAEK---LH 352
             + + GS LPSV S + +    H   +          ++EIQ   + + L Y +    LH
Sbjct: 2338 SQGKTGSILPSVGSSVGSVNGYHTCKD----------LTEIQCDMSDVNLKYEKLGGVLH 2387

Query: 353  RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 412
              +     +LN  R +E H +        A + L WL  KEE   + D     T     K
Sbjct: 2388 ERQESLQAILN--RMEEVHKE--------ANSVLQWLESKEEVLKSMDAMSSPTKTETVK 2437

Query: 413  DYHAELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQ---TQWSWILQL 467
                     L + E+N   +Q++ E L  LL  +P     E ++   +   ++W    ++
Sbjct: 2438 AQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV 2497

Query: 468  CQCVEQHIKENTAYFEFFNDAK-EATDYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQES 524
                ++ ++E+ ++   F  A+ +   +L  + L   +    S D  + ++  +  VQ  
Sbjct: 2498 TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSID-PNMLNAQKQQVQFM 2556

Query: 525  MEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ--IEITIYKD 582
            ++E E   Q    +     +A   I   P   D  L TS   K +    Q  +E+T   +
Sbjct: 2557 LKEFEARRQQHEQL----NEAAQGILTGP--GDVSLSTSQVQKELQSINQKWVELTDKLN 2610

Query: 583  ------DECVLANNSHRAKWKVISP----TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 632
                  D+ ++ +  ++   + +S      G    V S   T P   K+ ++  + I   
Sbjct: 2611 SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD 2670

Query: 633  YQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFED 692
             +    L HE                      A  +    ++L GE Q +   L+ R E 
Sbjct: 2671 LEQ---LDHEVK-------------------EAQTLCDELSVLIGE-QYLKDELKKRLET 2707

Query: 693  FLEDSQESQVFSGSDITQLEKEVNVCKQYYQ--ELLKSAEREEQEESVYNLYISEVRNIR 750
                 Q  +  +   I +L+  +   +Q+ Q  + L++   ++Q +   N  IS      
Sbjct: 2708 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA----- 2762

Query: 751  LRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ 810
             +LE  + +L                     E E+ +K L +       I  + E     
Sbjct: 2763 -KLERLQSQL--------------------QENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801

Query: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT-VNLVLKNTQAAEALVKLYETKL 869
                    TL+++L  +  +  ++   ++    +LK  +    K     E LV   E   
Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861

Query: 870  CE--EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKER 927
             +  E  V  D   +E+ +   K   +EV+++R +   L        + +D +  +    
Sbjct: 2862 AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN-------SAADILINS---S 2911

Query: 928  DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987
            + D D  +++   + +    V  ++  +   LE + + L+ +++++  ++   ++VE  +
Sbjct: 2912 EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE---KKVEGAK 2968

Query: 988  RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1047
             +++         +   L  Q      +E  +++ +  Q    Q      DY L+  T  
Sbjct: 2969 HQLE---------IFDALGSQACSNKNLEKLRAQQEVLQALEPQV-----DY-LRNFTQG 3013

Query: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEI 1107
             + D+   S   +   Q  A++  QEF++++ R  +   +M   ++  G    R+ E   
Sbjct: 3014 LVEDAPDGSDASQLLHQ--AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREM-- 3069

Query: 1108 KRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREA 1167
                  S+     D L    A   +   L  +I ++   + ++   K  +E    + R  
Sbjct: 3070 -----FSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHM 3124

Query: 1168 AENE----LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI- 1222
             E E    L   +R +E ++ Q  +     K  + +LE  +   E   R+L+ +   T  
Sbjct: 3125 LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTA 3184

Query: 1223 --EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQ---QKNKLMEEL 1277
              EAEA +  V   +     QL +    ++   D L+ K   +N L Q   Q      ++
Sbjct: 3185 AEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDV 3244

Query: 1278 RRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPV 1337
            +    + EE+      + K +A +    ++ L    K +      ++ +  T    A   
Sbjct: 3245 QGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQK 3304

Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ-----DMRELTYELNAL 1392
             P  +    +A    +Q+  ++  ++ K  VD L A   +  Q     D  ++T +L +L
Sbjct: 3305 PPSAEYKVVKAQIQ-EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363

Query: 1393 QLEKTSSEEKARLLKDKLD----------ETNNTLRCLKLELERKDQAEKGYSQQLRELG 1442
            +   T    KA   + +L+          ET   +       E+K    +    Q  ++ 
Sbjct: 3364 ESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQ 3423

Query: 1443 RQLNQTTGKAEEAMQEASDLKK-IKRNYQLELESLNHEKGKLQREVDRITRAHAVAE--- 1498
            +Q+ +     E+    A+D+ + +K    L   +   E+G L  ++D +   ++  +   
Sbjct: 3424 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3483

Query: 1499 -KNIQHLNSQIHSFR--DEKELERLQICQRKSDHLKEQFEKSHEQ------------LLQ 1543
             +    L+  + + R   E E+E L       D L   F K  +Q            L +
Sbjct: 3484 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 3543

Query: 1544 NIKAEKENNDKI---------QRLNEELEKSNECAEMLKQKVEELT-------RQNNETK 1587
             I   K+N D+          Q   EE+    E  + +K +  ++T       R   + +
Sbjct: 3544 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 3603

Query: 1588 LMMQRIQAESENIV-----LEKQT---------------IQQRCEALKIQADGFKDQLRS 1627
             +  + Q+  E +      +E++                 QQR + LK +    +  L +
Sbjct: 3604 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 3663

Query: 1628 TNEHLHKQTKTEQDFQRK-IKCLEEDLAKSQNLVSE-FKQKCDQQNIIIQNTKKEVRNLN 1685
             NE      +      R+ +  L  D  +   LVS+   Q+ D+ +  IQ +++  +  +
Sbjct: 3664 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723

Query: 1686 AELNASKEEKRR----GEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF- 1740
            AEL    E KR+    G  +++  Q   Q    +   +    H  +++E  +HR  +   
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 3783

Query: 1741 --QEESGKFKQSAEEFRKKME--KLMESKVITENDISGIRLD-FVSLQQENSRAQENAKL 1795
              +E+    ++  E   ++ E   L+ S+     + + + ++ F    +E S   E  + 
Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843

Query: 1796 CETNIKEL---ERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM-DQ 1851
                +        QL+Q +E+M+Q +   A H     KL  ++  Q +E+   + +M ++
Sbjct: 3844 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-KIGPQLKELNPEEGEMVEE 3902

Query: 1852 QIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            + ++ E+    ++ E+++++ A D                  E  S++T          +
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALD------------------EAVSQST---------QI 3935

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFD 1971
              +  + +P+ E      +E +   ++  PP  P E +K ++C S+  S T  EL+    
Sbjct: 3936 TEFHDKIEPMLE-----TLENLSSRLR-MPPLIPAEVDKIRECISDNKSAT-VELEKLQP 3988

Query: 1972 ETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMEL-------------VKVLTPLEIA 2018
                + R  E    R Q  +        QD   +M               +K L  LE+A
Sbjct: 3989 SFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELA 4048

Query: 2019 KNKQYDMHTEVTTLKQEKNPVPSAE 2043
            +   YDM   +TT+K  ++ V   E
Sbjct: 4049 EKFWYDMAALLTTIKDTQDIVHDLE 4073



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 294/1718 (17%), Positives = 668/1718 (38%), Gaps = 256/1718 (14%)

Query: 349  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408
            E   R+E  Y K++  +   + H++T         + + W   +++ ++   W+      
Sbjct: 931  EMASRVEQSYQKVM--ALWHQLHVNT--------KSLISWNYLRKDLDLVQTWNLEKLRS 980

Query: 409  ARKKDYHAELMRELDQKEENIKS------VQEIAEQLLLENHPARLTIEAYRAAMQTQWS 462
            +   + H ++M+ L    E+         +  +A++L LE       +EA +A  Q    
Sbjct: 981  SAPGECH-QIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEE-----VEACKARFQ---- 1030

Query: 463  WILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LED- 519
                L + +E   KE T    + ++ K     L   +  + ++     SS   +   +D 
Sbjct: 1031 ---HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDN 1087

Query: 520  --LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP------------------ 559
               + E    +E+L Q +S +  +  K  + +   P +S  P                  
Sbjct: 1088 ALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYG 1147

Query: 560  --------LKT-SIPIKAICDYRQI----EITIYKDDECVLANNSHRAKWKVI----SPT 602
                    LKT  + +++I D   +    EI + +++  +   ++  A W  +    S  
Sbjct: 1148 LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDV 1207

Query: 603  GNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 662
             ++  V SV        K   +  +R+  +    L  + E    ++    WH +I +++ 
Sbjct: 1208 KDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQE--RWHRVIAQLE- 1264

Query: 663  IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYY 722
            IR S + SI+ +L G+++     L    E+     +  +     D   L ++++     +
Sbjct: 1265 IRQSELESIQEVL-GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALF 1323

Query: 723  QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITE 782
             E+ ++  + +Q +     Y + V++  L+L   +  +  Q ++P +R  +  S   IT+
Sbjct: 1324 AEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQ 1383

Query: 783  QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI 842
            +     +L      L T+T +  ++ S A     +  L  E  VV +   +       ++
Sbjct: 1384 EFM---DLRTRYTALVTLTTQHVKYISDA-----LRRLEEEEKVVEEEKQE-------HV 1428

Query: 843  DKLKT----VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDE 898
            +K+K     V+ + +NTQ      +  E+   + E  I ++  +   ++T K+  SE  +
Sbjct: 1429 EKVKELLGWVSTLARNTQGKATSSETKEST--DIEKAILEQQVLSEELTTKKEQVSEAIK 1486

Query: 899  KRQVF---HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
              Q+F   H  +   ++ K IS+++    K        + +  D    + Q +  Q+ ++
Sbjct: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKA-------YHDLCDGSANQLQQLQSQLAHQ 1539

Query: 956  LRDLEGIGKSLKYYRDTYHP-LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
                    K+L+  ++T H  L+D    V   +R +  +Q   ++   + L + +  + +
Sbjct: 1540 TEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKD 1594

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
            ++      D+ Q  A  ++  VKD E      +  +  ++ + ++ +  Q+       E 
Sbjct: 1595 LQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY---EA 1645

Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LEN 1133
            +   TR      +  + ++ A  S  + E E+ K  KE +E+    D L     +V    
Sbjct: 1646 LQEETR------VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699

Query: 1134 SKLTGKISELERMV-AELKKQK----------SRVEEELPK---VREAAENELRKQQRNV 1179
             +L   +  +E++  A L+K            ++  E+L K   + +A   EL  QQ+N 
Sbjct: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQN- 1758

Query: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR 1239
                L    A++   Q+   L     E++  +++L  +++    + A+  A  + +   +
Sbjct: 1759 --FILATQSAQAFLDQHGHNLTP--EEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ 1814

Query: 1240 NQLEENTFTRRTLEDHLKRKDLSLNDLEQ---QKNKLMEELRRKRDNEEELL-------- 1288
            ++L++     +  E  L+R +  L ++ +       L   L+R+    E+++        
Sbjct: 1815 DELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRF 1874

Query: 1289 -----KLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPI--- 1340
                 + +  ME      K+ +E     K K++ +A  + T +   C      +  +   
Sbjct: 1875 VTISGQKVLDMENSFKEGKEPSEIGNLVKDKLK-DATERYTALHSKCTRLGSHLNMLLGQ 1933

Query: 1341 -----TQATSCRA-VTGLQQEHDKQKAEELKQQ---VDELTAANRKAEQDMRELTYELNA 1391
                   A S +A +   +   +K  ++ +      + E  A  ++ ++++ E  +++  
Sbjct: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE--HQVPV 1991

Query: 1392 LQLEKTSSE------EKA---RLLKDKLDETNNTLRCLKLEL-ERKDQAEKGY--SQQLR 1439
             +L+K + +      E A   R +++  D   +  + L   L ER    +K    SQ ++
Sbjct: 1992 EKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQ 2051

Query: 1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEK 1499
            E    L Q+ G+ E+ + E   +  +      E  + N    KL++++ R        + 
Sbjct: 2052 ESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATNM---KLKQDIAR-------QKS 2100

Query: 1500 NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLN 1559
            +++     +  F +  +     + Q K   + ++FE+   Q       ++E    +++L 
Sbjct: 2101 SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ-------QQEKESSLKKLL 2153

Query: 1560 EELEKSNECAEMLKQKVEELTRQ---NNETKLMMQRIQAESENIVLEKQTIQQRCEALK- 1615
             + E     +  L+Q +E  +R     N+    +     + + + LE +  Q+  + L+ 
Sbjct: 2154 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH 2213

Query: 1616 ----IQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQN 1671
                + + GF   L    + +    K   + Q+ +K  E+D +  Q  + EF++      
Sbjct: 2214 LVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQ 2273

Query: 1672 IIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQ 1731
              ++ T+  +      ++A + EK            Q++ L + L    D     T+ E+
Sbjct: 2274 KWLKETEGSIPPTETSMSAKELEK------------QIEHLKSLL---DDWASKGTLVEE 2318

Query: 1732 MTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL--DFVSLQQENSRA 1789
            +  +   L   E+   + +A + + K   ++ S   +   ++G     D   +Q + S  
Sbjct: 2319 INCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2375

Query: 1790 QENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849
                +     + E +  LQ    +M++  H EAN   +  + ++E++          + M
Sbjct: 2376 NLKYEKLGGVLHERQESLQAILNRMEE-VHKEANSVLQWLESKEEVL----------KSM 2424

Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRS 1909
            D      + + V  Q E  K        F  + E    + Q   ++     G L   P S
Sbjct: 2425 DAMSSPTKTETVKAQAESNK-------AFLAELEQNSPKIQ---KVKEALAGLLVTYPNS 2474

Query: 1910 -PLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPL 1946
                 W +  + L  +W+      + ++ Q +   + L
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHL 2512



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 233/1166 (19%), Positives = 424/1166 (36%), Gaps = 235/1166 (20%)

Query: 781  TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVVLQNMNQVYSMS 838
            T+  K+++++ R K     I N   +         S+ +L S  E  V+ + ++ + +  
Sbjct: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARY 3476

Query: 839  STYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST-LKQWRSEVD 897
            S   D+      +L    +   L    E ++    A + DK     L S  +K ++ +V 
Sbjct: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK-----LSSVFVKDFKQDVL 3531

Query: 898  EKRQVFH-ALEDELQKAKAISDEMFK--------TYKERDLDFDWHKEKADQLVERWQNV 948
             ++   H AL +E+   K   D+  K        T  E  L     +EK D +  R+ ++
Sbjct: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI---QEKLDGIKTRYADI 3588

Query: 949  HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR-------------KIQENQP 995
             V     LR LE   +    ++ TY  L  W+++VE                 + Q+ Q 
Sbjct: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQK 3648

Query: 996  ENSK--------------------------------TLATQLNQQKMLVSE-IEMKQSKM 1022
            E  K                                 L +  N+Q  LVS+ I  +  ++
Sbjct: 3649 ELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEI 3708

Query: 1023 DECQKYAEQYSATVKDYELQTM--TYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL--- 1077
            D   + ++QY     D EL  +  T R ++      P++  + Q++A L +Q+   +   
Sbjct: 3709 DAAIQRSQQYEQAA-DAELAWVAETKRKLM---ALGPIRLEQDQTTAQLQVQKAFSIDII 3764

Query: 1078 --RTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSK 1135
              +     L +  ++     G+  K + +E+ +             L+Q+ +A  L NS+
Sbjct: 3765 RHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE------------SLIQQYEAISLLNSE 3812

Query: 1136 LTGKISELERMVAELKKQKSRVEEELPKVREAA------------ENELRKQQRNV---- 1179
               + + LER    + +     EE  P + E                +LR+QQ  +    
Sbjct: 3813 ---RYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 3869

Query: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERVR----QLTIEAEAKRAAVEE-- 1233
            E I+  K   +   K   +  E    E E  E + ++      Q+  E   +  A++E  
Sbjct: 3870 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 3929

Query: 1234 ----NLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
                 +  F +++E    T   L   L+   L    +  + +K+ E +   +    EL K
Sbjct: 3930 SQSTQITEFHDKIEPMLETLENLSSRLRMPPL----IPAEVDKIRECISDNKSATVELEK 3985

Query: 1290 L------IKQMEKDLAFQKQVAEKQLKEKQ---KI--------ELEARRKITEIQYTCRE 1332
            L      +K+  ++L  + Q A+K L  K+   K+        +++AR +  EI++    
Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045

Query: 1333 NALPVCPITQATSCRAVTGLQQ-EHDKQK----AEELKQQVDELTAANRKAEQDMRELTY 1387
                      A     +   Q   HD +        +KQQV+       + +    EL +
Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105

Query: 1388 -ELNALQLEKTSSEEKARLLKDKLDETNNTLRCL------KLE-LERKDQAEKGYSQQLR 1439
              +    L     E +   ++  +DE NN    L      +LE LE   QA   Y   L+
Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQ 4165

Query: 1440 ELGRQLNQTTGK-------------AEEAMQEASDLKKIKRNYQLELESLNHE-KGKLQR 1485
             +   L+ T  K              ++ + E  + K      Q+E+E LNH+ +  L++
Sbjct: 4166 AMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKK 4225

Query: 1486 EVDRITR---------------------AH--------AVAEKNIQHLNSQIHSF----- 1511
              D   R                     AH         +A    QH   ++ S+     
Sbjct: 4226 ATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE 4285

Query: 1512 ----------RDEK--ELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLN 1559
                       D K  E+E  +    K+D L  Q          N   E    D    L 
Sbjct: 4286 ELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLR 4345

Query: 1560 EELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQAD 1619
              LE  N+C E + QK EE  +Q   T    Q   +E E+ +LE   ++ +  A K    
Sbjct: 4346 SRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK-PTG 4404

Query: 1620 GFKDQLR---STNEHLHKQTKTEQDF------QRKIKCLEED----LAKSQNLVSEFKQK 1666
            G  +  R    T+  L+ Q K +++       + ++  L  D     +K++  V+  +QK
Sbjct: 4405 GLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4464

Query: 1667 CDQQNIIIQNTK---KEVRNLNAELNASKEE----KRRGEQKVQLQQAQVQELNNRLKKV 1719
                +  ++  K   +E  NL  E   S +E        EQ + +       LN  L ++
Sbjct: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 4524

Query: 1720 QDELHLKTIEEQMTHRKMVLFQEESG 1745
            ++  H     E   HR  ++  +++G
Sbjct: 4525 EE--HKVFANEVNAHRDQIIELDQTG 4548



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 157/917 (17%), Positives = 328/917 (35%), Gaps = 155/917 (16%)

Query: 1116 HGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQ 1175
            H +Y++ L + +    +  KL    S   R +  L K  SR   EL  + E  E EL   
Sbjct: 651  HTSYAETLGKLET---QYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYD 707

Query: 1176 -QRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL-TIEAEAKRAAVEE 1233
               N  +IS ++         Y  EL   + EK+   R L+   +L ++E    +  VE 
Sbjct: 708  WSDNNSNISAKR--------NYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEA 759

Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRKDL------SLNDLEQQKNKLMEELRRKRDNEEEL 1287
                 ++QL+        +E H+K             +LE     L + ++RK   +   
Sbjct: 760  YSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNT 819

Query: 1288 LKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR 1347
               + ++E  L       E+ ++ K  +     R  T +Q   R    P   +    S +
Sbjct: 820  S--LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRS---PDHVLKNTISVK 874

Query: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLK 1407
            AV   +Q               E+T                 +   LE  S   K +++ 
Sbjct: 875  AVCDYRQI--------------EITICKN-------------DECVLEDNSQRTKWKVIS 907

Query: 1408 DKLDETNNTLRCLKLELERKD------QAEKGYSQQLRELGRQLNQTTGKAEEAMQEASD 1461
               +E      C  +    KD      + E+ Y Q++  L  QL+  T           D
Sbjct: 908  PTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY-QKVMALWHQLHVNTKSLISWNYLRKD 966

Query: 1462 LKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL-NSQIHSFRDEKELER- 1519
            L  ++      LE L         ++ +  +AH   E  +Q   +S + S  D   LE  
Sbjct: 967  LDLVQT---WNLEKLRSSAPGECHQIMKNLQAHY--EDFLQDSRDSVLFSVADRLRLEEE 1021

Query: 1520 LQICQRKSDHLKEQFE-KSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEE 1578
            ++ C+ +  HL +  E +  E+ +  +   +  N +++    E         +   + + 
Sbjct: 1022 VEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDR 1081

Query: 1579 LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTN--------- 1629
               Q+N  ++      AE E+   + Q ++   +A+ ++ D F  Q  S++         
Sbjct: 1082 DAWQDNALRI------AEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135

Query: 1630 -------EHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK---- 1678
                   +H++  +    +  + +  +   +  ++ LV  ++ K  Q+ +++ +      
Sbjct: 1136 NLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195

Query: 1679 ---------KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKK-------VQDE 1722
                      +V++ N+  +   EE  + +   +       E N  L++       +Q+ 
Sbjct: 1196 HWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQER 1255

Query: 1723 LHLKTIEEQMTHRKMVLFQEESGKFKQ------------SAEEFRKKMEKLMESKVITEN 1770
             H    + ++   ++   QE  G ++             +A++   K  +  +S+V++E 
Sbjct: 1256 WHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQ 1315

Query: 1771 DISGIRLDFVSLQQENSRAQENAKLCE---TNIKELERQLQQYREQMQQGQH-------- 1819
             +S     F  +++  ++  +  K  +   T +K+ E QL  Y+  ++  Q         
Sbjct: 1316 -LSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRM 1374

Query: 1820 -----------------------MEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEH 1856
                                   +   H +        L  +++ VE  KQ+  +++KE 
Sbjct: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKEL 1434

Query: 1857 EHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQ 1916
               +  L    Q K+T+ +     D E  + E Q   E  +     +    ++  +   +
Sbjct: 1435 LGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAK 1494

Query: 1917 EPQPLEEKWQHRVVEQI 1933
                L EK + ++ EQ+
Sbjct: 1495 HGHKLSEKEKKQISEQL 1511



 Score = 39.3 bits (90), Expect = 0.052
 Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322
            K S L+Q L + E+    V  LL W+ E +  L  R     D  +++S ++ HK   + +
Sbjct: 4802 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 4861

Query: 323  EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377
            EE    +  A  + E+ +         T    +  + +++ ++L  ++  ++ L+T L  
Sbjct: 4862 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 4921

Query: 378  FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431
             V+ A      L W+   E   +  D      NI R K     H   M E+ +K+ ++  
Sbjct: 4922 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 4981

Query: 432  VQEIAEQLLLE 442
            V +  ++  +E
Sbjct: 4982 VTKTYKRKNIE 4992



 Score = 36.2 bits (82), Expect = 0.44
 Identities = 50/224 (22%), Positives = 101/224 (45%), Gaps = 16/224 (7%)

Query: 279  MKFVQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS- 335
            M  +Q L++W+ +++ QL  D+   G DL  V + ++ HK   + + +   +++  K S 
Sbjct: 4709 MDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 4767

Query: 336  -EIQMTAPLKLTYAE-KLHRLESQYAKLLNTSRNQERHLDTL--HNFVSRATNELI--WL 389
             E+   +    T+ + +L  L +++  +   S +++  L+       V R T  ++  WL
Sbjct: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827

Query: 390  NEKEEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
            +E E+          +T   +   D H E M+++++K  ++ S   + E +L   HP  +
Sbjct: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 4887

Query: 449  T-----IEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
            T     I   RA  +   +W  Q  Q +E  + E  A  E   +
Sbjct: 4888 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEE 4931


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1415

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1833

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1890

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQR 2211



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1168 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1226 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1273

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1274 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1332 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1565

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1566 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1623 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1855

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2094 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2206

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2267 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2322

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2323 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2381 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2439 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2676

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2736

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2737 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2796

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2856

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2857 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2916

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 2917 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2975

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 2976 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3022

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 3023 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3080

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3081 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3140

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3141 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3200

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3201 PDQLTGLSLLPLSE 3214



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3819 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3870

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 3871 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3919

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 3920 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3979

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 3980 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4160 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4219

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4220 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4279

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4280 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4339

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4340 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4399

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4400 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4459

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4460 GLRLLEAAAQSTKGYYSPY 4478



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3297 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3356

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3357 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3416

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3417 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3476

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3477 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3536

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3537 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3594

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3595 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3653

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3654 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3709

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3710 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3769

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3770 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3829

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3830 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3879



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 2974 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3033

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3034 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3093

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3094 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3153

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3154 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3213

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3214 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3256

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3257 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3308

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3309 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3368

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3369 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3428

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3429 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3488

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3489 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3541



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3643 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3702

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3703 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3762

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3763 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3822

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3823 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3881

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 3882 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3941

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 3942 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3997

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 3998 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4160 KGLIDHQTYLELSEQE 4175



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2660 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2717

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2718 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2777

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2778 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2837

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2838 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2897

Query: 2648 SS 2649
             S
Sbjct: 2898 DS 2899



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 390 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 449

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 450 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 522  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 582  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 642  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 702  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 762  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 822  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 882  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 942  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1300

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1360

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1419

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1539

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1540 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1837

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1894

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2193

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2194 TLRLQLEETDHQKNLLDEELQR 2215



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1172 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1229

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1230 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1277

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1278 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1335

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1336 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1512

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1569

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1570 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1627 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1682

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1683 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1742

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1859

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2098 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2210

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2271 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2326

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2327 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2385 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2442

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2443 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2621 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2680

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2681 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2740

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2741 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2800

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2801 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2860

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2861 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2920

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 2921 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2979

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 2980 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3026

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 3027 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3084

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3085 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3144

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3145 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3204

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3205 PDQLTGLSLLPLSE 3218



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3823 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3874

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 3875 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3923

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 3924 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3983

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 3984 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4043

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4044 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4103

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4104 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4163

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4164 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4223

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4224 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4283

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4284 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4343

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4344 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4403

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4404 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4463

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4464 GLRLLEAAAQSTKGYYSPY 4482



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3301 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3360

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3361 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3420

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3421 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3480

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3481 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3540

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3541 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3598

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3599 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3657

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3658 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3713

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3714 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3773

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3774 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3833

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3834 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3883



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 2978 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3037

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3038 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3097

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3098 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3157

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3158 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3217

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3218 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3260

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3261 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3312

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3313 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3372

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3373 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3432

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3433 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3492

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3493 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3545



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3647 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3706

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3707 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3766

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3767 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3826

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3827 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3885

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 3886 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3945

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 3946 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 4001

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 4002 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4043

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4044 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4103

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4104 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4163

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4164 KGLIDHQTYLELSEQE 4179



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2664 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2721

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2722 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2781

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2782 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2841

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2842 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2901

Query: 2648 SS 2649
             S
Sbjct: 2902 DS 2903



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 394 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 453

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 454 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 491


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1415

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1833

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1890

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQR 2211



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1168 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1226 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1273

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1274 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1332 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1565

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1566 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1623 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1855

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2094 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2206

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2267 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2322

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2323 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2381 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2439 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2676

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2736

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2737 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2796

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2856

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2857 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2916

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 2917 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2975

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 2976 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3022

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 3023 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3080

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3081 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3140

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3141 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3200

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3201 PDQLTGLSLLPLSE 3214



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3819 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3870

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 3871 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3919

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 3920 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3979

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 3980 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4160 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4219

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4220 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4279

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4280 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4339

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4340 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4399

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4400 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4459

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4460 GLRLLEAAAQSTKGYYSPY 4478



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3297 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3356

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3357 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3416

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3417 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3476

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3477 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3536

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3537 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3594

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3595 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3653

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3654 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3709

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3710 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3769

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3770 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3829

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3830 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3879



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 2974 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3033

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3034 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3093

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3094 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3153

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3154 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3213

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3214 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3256

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3257 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3308

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3309 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3368

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3369 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3428

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3429 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3488

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3489 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3541



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3643 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3702

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3703 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3762

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3763 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3822

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3823 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3881

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 3882 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3941

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 3942 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3997

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 3998 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4160 KGLIDHQTYLELSEQE 4175



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2660 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2717

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2718 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2777

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2778 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2837

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2838 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2897

Query: 2648 SS 2649
             S
Sbjct: 2898 DS 2899



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 390 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 449

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 450 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 486  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 546  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 606  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 666  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 726  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 786  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 846  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 906  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 966  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1264

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1324

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1383

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1801

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1858

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2157

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2158 TLRLQLEETDHQKNLLDEELQR 2179



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1136 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1193

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1194 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1241

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1242 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1299

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1300 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1476

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1477 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1533

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1534 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1591 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1646

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1647 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1706

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1823

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2062 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2174

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2235 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2290

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2291 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2349 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2406

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2407 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2585 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2644

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2645 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2704

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2705 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2764

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2765 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2824

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2825 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2884

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 2885 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2943

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 2944 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 2990

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 2991 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3048

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3049 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3108

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3109 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3168

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3169 PDQLTGLSLLPLSE 3182



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3787 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3838

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 3839 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3887

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 3888 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3947

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 3948 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4007

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4008 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4067

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4068 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4127

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4128 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4187

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4188 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4247

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4248 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4307

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4308 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4367

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4368 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4427

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4428 GLRLLEAAAQSTKGYYSPY 4446



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3265 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3324

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3325 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3384

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3385 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3444

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3445 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3504

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3505 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3562

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3563 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3621

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3622 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3677

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3678 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3737

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3738 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3797

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3798 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3847



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 2942 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3001

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3002 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3061

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3062 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3121

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3122 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3181

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3182 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3224

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3225 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3276

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3277 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3336

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3337 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3396

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3397 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3456

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3457 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3509



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3611 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3670

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3671 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3730

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3731 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3790

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3791 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3849

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 3850 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3909

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 3910 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3965

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 3966 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4007

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4008 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4067

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4068 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4127

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4128 KGLIDHQTYLELSEQE 4143



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2628 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2685

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2686 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2745

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2746 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2805

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2806 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2865

Query: 2648 SS 2649
             S
Sbjct: 2866 DS 2867



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 358 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 417

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 418 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 455


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 655  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 715  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 775  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 835  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 895  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 955  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1552

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1970

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 2027

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2326

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2327 TLRLQLEETDHQKNLLDEELQR 2348



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1305 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1363 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1410

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1411 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1468

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1469 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1645

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1646 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1702

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1703 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1760 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1815

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1816 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1875

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1992

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2231 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2343

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2404 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2459

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2460 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2518 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2575

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2576 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2754 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2813

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2814 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2873

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2874 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2933

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2934 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2993

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2994 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 3053

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 3054 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 3112

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 3113 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3159

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 3160 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3217

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3218 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3277

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3278 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3337

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3338 PDQLTGLSLLPLSE 3351



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3956 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 4007

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 4008 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 4056

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 4057 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 4116

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 4117 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4176

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4177 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4236

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4237 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4296

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4297 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4356

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4357 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4416

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4417 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4476

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4477 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4536

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4537 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4596

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4597 GLRLLEAAAQSTKGYYSPY 4615



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3434 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3493

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3494 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3553

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3554 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3613

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3614 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3673

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3674 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3731

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3732 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3790

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3791 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3846

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3847 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3906

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3907 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3966

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3967 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 4016



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 3111 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3170

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3171 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3230

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3231 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3290

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3291 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3350

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3351 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3393

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3394 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3445

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3446 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3505

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3506 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3565

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3566 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3625

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3626 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3678



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3780 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3839

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3840 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3899

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3900 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3959

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3960 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 4018

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 4019 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 4078

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 4079 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 4134

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 4135 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4176

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4177 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4236

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4237 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4296

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4297 KGLIDHQTYLELSEQE 4312



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2797 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2854

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2855 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2914

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2915 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2974

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2975 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 3034

Query: 2648 SS 2649
             S
Sbjct: 3035 DS 3036



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 527 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 586

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 587 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1393

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1811

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1868

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2167

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2168 TLRLQLEETDHQKNLLDEELQR 2189



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1146 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1204 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1251

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1252 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1309

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1310 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1426

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1486

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1487 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1543

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1544 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1600

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1601 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1656

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1657 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1716

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1833

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2072 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2184

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2245 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2300

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2301 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2359 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2416

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2417 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2595 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2654

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2655 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2714

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2715 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2774

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2775 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2834

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2835 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2894

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 2895 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2953

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 2954 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3000

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 3001 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3058

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3059 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3118

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3119 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3178

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3179 PDQLTGLSLLPLSE 3192



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3797 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3848

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 3849 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3897

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 3898 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3957

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 3958 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4017

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4018 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4077

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4078 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4137

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4138 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4197

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4198 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4257

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4258 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4317

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4318 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4377

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4378 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4437

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4438 GLRLLEAAAQSTKGYYSPY 4456



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3275 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3334

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3335 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3394

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3395 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3454

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3455 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3514

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3515 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3572

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3573 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3631

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3632 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3687

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3688 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3747

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3748 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3807

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3808 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3857



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 2952 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3011

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3012 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3071

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3072 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3131

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3132 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3191

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3192 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3234

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3235 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3286

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3287 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3346

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3347 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3406

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3407 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3466

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3467 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3519



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3621 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3680

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3681 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3740

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3741 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3800

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3801 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3859

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 3860 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3919

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 3920 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3975

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 3976 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4017

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4018 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4077

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4078 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4137

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4138 KGLIDHQTYLELSEQE 4153



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2638 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2695

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2696 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2755

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2756 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2815

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2816 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2875

Query: 2648 SS 2649
             S
Sbjct: 2876 DS 2877



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 368 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 427

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 428 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 504  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 564  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 624  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 684  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 744  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 804  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 864  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 924  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 984  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1282

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1401

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1521

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1522 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1641

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1819

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1820 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1876

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1996

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2056

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2175

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2176 TLRLQLEETDHQKNLLDEELQR 2197



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1154 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1211

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1212 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1259

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1260 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1317

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1318 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1434

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1494

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1495 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1551

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1552 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1608

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1609 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1664

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1841

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2080 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2192

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2253 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2308

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2309 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2367 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2424

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2425 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2662

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2663 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2722

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2723 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2782

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2783 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2842

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2843 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2902

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 2903 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2961

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 2962 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3008

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 3009 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3066

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3067 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3126

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3127 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3186

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3187 PDQLTGLSLLPLSE 3200



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3805 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3856

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 3857 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3905

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 3906 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3965

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 3966 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4025

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4026 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4085

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4086 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4145

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4146 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4205

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4206 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4265

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4266 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4325

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4326 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4385

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4386 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4445

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4446 GLRLLEAAAQSTKGYYSPY 4464



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3283 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3342

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3343 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3402

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3403 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3462

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3463 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3522

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3523 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3580

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3581 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3639

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3640 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3695

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3696 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3755

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3756 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3815

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3816 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3865



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 2960 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3019

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3020 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3079

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3080 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3139

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3140 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3199

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3200 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3242

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3243 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3294

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3295 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3354

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3355 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3414

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3415 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3474

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3475 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3527



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3629 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3688

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3689 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3748

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3749 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3808

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3809 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3867

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 3868 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3927

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 3928 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3983

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 3984 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4025

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4026 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4085

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4086 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4145

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4146 KGLIDHQTYLELSEQE 4161



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2646 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2703

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2704 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2763

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2764 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2823

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2824 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2883

Query: 2648 SS 2649
             S
Sbjct: 2884 DS 2885



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 376 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 435

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 436 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 473


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  923 bits (2385), Expect = 0.0
 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 545  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 605  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 665  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 725  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 785  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 845  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 905  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 965  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323

Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383

Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1442

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502

Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562

Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682

Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742

Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1860

Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1917

Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977

Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2037

Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750
            +     KV++   L+   EQ + R++ L QE + K  Q+                     
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097

Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790
                        AE  R+  E+  E++V  E + +          RL   + +Q  +RAQ
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157

Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847
              A   KL +   +E  R+ Q  +  ++Q Q  +A   +K +K  ++ + QK +VE    
Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2216

Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869
             +  Q++E +HQ  LL  E+Q+
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQR 2238



 Score =  431 bits (1108), Expect = e-120
 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%)

Query: 677  GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728
            GE    +   + R    LE  Q   V + +D+ Q E E +    +YY+E        L+ 
Sbjct: 1195 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788
            A R  ++E +  + +++ + +R +L        RQ +  LE  + H    ++ E ++  K
Sbjct: 1253 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1300

Query: 789  E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839
            + +  +KD +L  +T K +      A+ +  P ++S    V+Q       + +++ +++S
Sbjct: 1301 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1358

Query: 840  TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894
             YI   K ++  L+  +  E L +        +L E EA +  +  +    +  K Q   
Sbjct: 1359 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415

Query: 895  EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939
            E  E +Q           A  D  Q+ ++I +E+ +  +  + +      +A+       
Sbjct: 1416 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1475

Query: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998
            ++ E  + V +Q++   R   G    L+  R      +   +Q  E  +R  ++ Q E+ 
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1535

Query: 999  KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
            +    ++     + +E E  + K    Q   E     ++  E +    +A V+  ++  V
Sbjct: 1536 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1592

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
                 Q SA+    E    R  +      + + ++    ++ +L EE  +R ++ +E   
Sbjct: 1593 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1649

Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
              +  +R+    LE  +L   +   L     E+ +QKS  + E  K +E AE E R++ +
Sbjct: 1650 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1705

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
              E    Q+  AE E ++ R+  E   +++ AAE+EL R+R  T + E +R  +EE L  
Sbjct: 1706 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1765

Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293
             + +    T  R+ LE  L +    +  L   K +  EE R   +  ++ L+      ++
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825

Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            + ++ A  + +AE+  +++Q  E +A R+  E +    E    +  I +AT  +    + 
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1882

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408
             +  + + E L++  ++     R+ E+     +   E    QL K S  E  R   L++D
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942

Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L +       +  LK   E+    +     +L  +      T    E+A  EA+  +++
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519
                +           K     +   R    A + ++ L +++   R      +++   +
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062

Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
            LQ+ Q  +    +  EK+H   +Q  + E+E    +Q+    L++    AE  ++  EE 
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120

Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631
                 E ++  +R  A+S   V E + ++Q  E     + QA    ++LR   E      
Sbjct: 2121 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176

Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678
                   L ++   + + ++  K  E+ L +   +  E        ++ D Q  ++    
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2233

Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
            +E++ L AE   +  ++ + E+++   + Q++EL+    +++ E     + ++   ++ +
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293

Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795
              QEE+ K KQ AEE  +      E+   + + E D++  R     + +E  +A + A  
Sbjct: 2294 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2349

Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
              T +K     LQQ +E  Q Q + ++ +  Q  Q+L +E    +R +E  +Q+  +   
Sbjct: 2350 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407

Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911
            E E +L L   E+   Q ++      F+   E  + E  H  EL+++    L  T     
Sbjct: 2408 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2465

Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970
             +   + + L E      +E+  +++Q +     L+ E+ Q    E   Q +  LQ +F 
Sbjct: 2466 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523

Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019
               D      R  E EK + + L           R   + Q    E E  +++  +E A+
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583

Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061
             +Q++    V   ++E   +           AEE          + E  RA+    +   
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643

Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119
              +    +T  N     D   +  + E  F GLR  V+A++L EA +L    +++L  G 
Sbjct: 2644 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2703

Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177
             TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQAA+
Sbjct: 2704 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2763

Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235
            GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+  +
Sbjct: 2764 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2823

Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295
            + R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F +P
Sbjct: 2824 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2883

Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345
            N  + L Y +LL  CV D E+   L P        GE   ++   +     + V      
Sbjct: 2884 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2943

Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384
              G  +T++E                      R  +EK I + ++  ++ + K  + FE 
Sbjct: 2944 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 3002

Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442
                         GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   + 
Sbjct: 3003 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3049

Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502
               + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V E
Sbjct: 3050 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3107

Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562
            A+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q  T
Sbjct: 3108 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3167

Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622
            GG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++  
Sbjct: 3168 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3227

Query: 2623 FDFHTGLKLLEVSE 2636
             D  TGL LL +SE
Sbjct: 3228 PDQLTGLSLLPLSE 3241



 Score =  414 bits (1064), Expect = e-115
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 3846 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3897

Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 3898 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3946

Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 3947 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 4006

Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 4007 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4066

Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 4067 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4126

Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 4127 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4186

Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 4187 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4246

Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 4247 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4306

Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 4307 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4366

Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 4367 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4426

Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 4427 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4486

Query: 2628 GLKLLEVSEPLMTGISSLY 2646
            GL+LLE +     G  S Y
Sbjct: 4487 GLRLLEAAAQSTKGYYSPY 4505



 Score =  262 bits (669), Expect = 4e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 3324 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3383

Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 3384 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3443

Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 3444 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3503

Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 3504 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3563

Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 3564 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3621

Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 3622 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3680

Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 3681 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3736

Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 3737 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3796

Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 3797 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3856

Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 3857 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3906



 Score =  219 bits (557), Expect = 4e-56
 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 3001 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3060

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 3061 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3120

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 3121 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3180

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 3181 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3240

Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 3241 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3283

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 3284 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3335

Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 3336 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3395

Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519
              + EA+ RGL                                      V     +QL  
Sbjct: 3396 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3455

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P +   +S+ +A+   ++ ++ GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 3456 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3515

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
             Q G     +   L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 3516 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3568



 Score =  207 bits (528), Expect = 8e-53
 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%)

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 3670 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3729

Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 3730 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3789

Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 3790 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3849

Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 3850 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3908

Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368
             ++       + +++  R  V+D  T  +    LT  E   +NL +          ++++
Sbjct: 3909 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3968

Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416
             + ++    +AM              E+   + +++   K GL   + EA+  G +    
Sbjct: 3969 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 4024

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
                        E  D LLS           V GY    SG+ IS+ +A ++ L+ +   
Sbjct: 4025 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4066

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            +R LEAQ++TGGIIDP    +  V  A  RGL DE   + L        G   P T + +
Sbjct: 4067 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4126

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581
            + ++ +   I + + G+  L  +                    +++P+    +S+ EA +
Sbjct: 4127 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4186

Query: 2582 VGIIDVLIATKLKDQK 2597
             G+ID     +L +Q+
Sbjct: 4187 KGLIDHQTYLELSEQE 4202



 Score =  114 bits (284), Expect = 2e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2687 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2744

Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2745 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2804

Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2805 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2864

Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2865 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2924

Query: 2648 SS 2649
             S
Sbjct: 2925 DS 2926



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 417 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 476

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 477 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  858 bits (2217), Expect = 0.0
 Identities = 647/2486 (26%), Positives = 1183/2486 (47%), Gaps = 329/2486 (13%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651

Query: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711

Query: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767

Query: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827

Query: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887

Query: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947

Query: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007

Query: 1086 TLMTQYIKFAGDSLKRLE------------EEEIK------------------------- 1108
            T    Y +F  + LK LE            EEE++                         
Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067

Query: 1109 RCKETSEHGAYSDLLQRQ-----KATVLENSKLTGKISELERMVAEL-------KKQKSR 1156
             C +     A  + L+RQ     K+      K  G+I EL   +  L       K+++  
Sbjct: 1068 ECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKS 1127

Query: 1157 VEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELER 1216
            VE+   + +   +   + +Q   E++  QK+ +E   K+   E+E   R +   + E  R
Sbjct: 1128 VEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE---RLRVLLQEEGTR 1184

Query: 1217 VRQLTIEAEAKRAAVEENLLNFRNQLE-ENTFTRRTL-------EDHLKRKDLSLNDLEQ 1268
             R+   E    R    E + N RN+ E E   T+ T+       ED  K     L+ L +
Sbjct: 1185 KREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR 1244

Query: 1269 QKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQY 1328
            +   L +E+ R  D+  +  +  ++ E++   QK    + +++KQ +E+E ++    +Q 
Sbjct: 1245 ENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQ---VMQQ 1301

Query: 1329 TCRENALPVCPITQATSCRAVTGLQQEHDKQKA---EELKQQ---VDELTAANRKAEQDM 1382
               +NA     + +A   + +    +E ++ KA   EE K++    +EL+      ++++
Sbjct: 1302 RSEDNARHKQSLEEA--AKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEI 1359

Query: 1383 RELTYELNA-LQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLREL 1441
              L  +    + + KT+  +   L   K ++T+      + +++   +  +  S++++ L
Sbjct: 1360 ISLKNQFETEINITKTTIHQ---LTMQKEEDTSG----YRAQIDNLTRENRSLSEEIKRL 1412

Query: 1442 GRQLNQTT---GKAEEAMQE--ASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAV 1496
               L QTT    + EE +Q+  A+  +  +R  QLE+E          R+V ++    +V
Sbjct: 1413 KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE---------LRQVTQMRTEESV 1463

Query: 1497 AEKNIQHLNSQIHSFRDE-KELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKI 1555
              K  Q L+    + +D+ KE+ER          LK+  +K       + K  ++ N ++
Sbjct: 1464 RYK--QSLDDAAKTIQDKNKEIER----------LKQLIDKE----TNDRKCLEDENARL 1507

Query: 1556 QRLNEELEKSN----ECAEMLKQKVEELTRQNNETKLMMQ----------RIQAESENIV 1601
            QR+  +L+K+N    E    LK + +ELTR   + + + Q          R Q   + + 
Sbjct: 1508 QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQ 1567

Query: 1602 LEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVS 1661
            L+KQ +++    LK          R+ +E   K+ K E++ +   + L+E   K  NL  
Sbjct: 1568 LQKQKVEEELNRLK----------RTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLT- 1616

Query: 1662 EFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQD 1721
               Q+ +Q +I+ + ++ ++R     L+    EK+R +++++   ++V+ L  +L + Q+
Sbjct: 1617 ---QQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673

Query: 1722 ELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVS 1781
             +    +  +   + +        + K   E  +   E L +  ++ E ++  +RL++  
Sbjct: 1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDD 1733

Query: 1782 LQQENSRAQENAKLCETNIKELERQLQ--QYREQMQQG-----QHMEANHYQKCQKLEDE 1834
            L++  S A  +       I EL  QLQ    R    QG     Q    N  Q+ +K + +
Sbjct: 1734 LRRGRSEADSDK---NATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQ 1790

Query: 1835 LIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGE 1894
             +     ++  K +  Q ++E E  LV ++   Q K+  +        E  +   + + E
Sbjct: 1791 ALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ------RLEDELNRAKSTLE 1844

Query: 1895 LSSRNTGHLH---PTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKS 1951
              +R    L       ++ L +W         K Q+   E+  ++++        E+EKS
Sbjct: 1845 AETRVKQRLECEKQQIQNDLNQW---------KTQYSRKEEAIRKIE-------SEREKS 1888

Query: 1952 QQCYSEYFSQTSTELQITFDETNPITRL-SEIEKIRDQALNNSRPPVRYQDNACEMELVK 2010
            ++  +   S+              I RL +EI++I ++         R   +  E E  +
Sbjct: 1889 EREKNSLRSE--------------IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934

Query: 2011 VLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPET 2070
                ++  + + Y  H E  T            EW                         
Sbjct: 1935 YQREIDKLRQRPYGSHRETQT----------ECEW------------------------- 1959

Query: 2071 FQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLN 2130
                      +V   +  F GLR  VTA QL E +L+D  T+++L  G K+VEEV   + 
Sbjct: 1960 ----------TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ 2009

Query: 2131 KFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYS 2190
             FL  A SIAG    S KEK S   A  + +I     +  LEAQAATG IIDP   +  +
Sbjct: 2010 PFLRGAGSIAGA-SASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLT 2068

Query: 2191 VEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQ 2248
            V+ A+ + ++D + R ++  AEKA  G+   +S KT+SV +A++  ++DR+ G  +LEAQ
Sbjct: 2069 VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQ 2128

Query: 2249 IASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLR 2308
            IASGGV+DPV  + +P ++AL +GL++  + + L++P  + + F +P  K+ + Y +L  
Sbjct: 2129 IASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 2188

Query: 2309 MCVFDVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLE 2368
             C  +  +   L    +R++S   +++              +TV E     ++  S   E
Sbjct: 2189 RCRIEPHTGLLLLSVQKRSMSFQGIRQ-------------PVTVTELVDSGILRPSTVNE 2235

Query: 2369 LSGQQYQWKEA-----MFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEG 2423
            L   Q  + E       F +     + +  +T T     I EA++ G +      +  E 
Sbjct: 2236 LESGQISYDEVGERIKDFLQGSSCIAGIYNET-TKQKLGIYEAMKIGLVRPGTALELLEA 2294

Query: 2424 LITLTELADSLLSRLVPKKDLHS-----------------PVAGYWLTASGERISVLKAS 2466
                  + D + +  +P ++ +                   V GY    +G  IS+ +A 
Sbjct: 2295 QAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAM 2354

Query: 2467 RRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITG 2526
             + L+++   +R LEAQ++TGGIIDP    +  V  A  RG  +E  ++ L        G
Sbjct: 2355 NKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKG 2414

Query: 2527 IGHPITNKMMSVVEAVNANIINKEMGIRCLEF-----QYLTGG----------LIEPQVH 2571
               P T + ++ ++     I ++E G+  L       Q  T            +++P+ +
Sbjct: 2415 FFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETN 2474

Query: 2572 SRLSIEEALQVGIIDVLIATKLKDQK 2597
              +S++EA + G+ID     +L +Q+
Sbjct: 2475 KEMSVQEAYKKGLIDYETFKELCEQE 2500



 Score =  377 bits (969), Expect = e-104
 Identities = 218/619 (35%), Positives = 346/619 (55%), Gaps = 50/619 (8%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIA 2140
            SV+     FQG+R  VT  +LV++ +L   T+ +L  G  + +EV + +  FL  ++ IA
Sbjct: 2202 SVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261

Query: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200
            G+Y E+TK+K+    A +  ++    AL  LEAQAATGFI+DP+S     VE+A  +G+V
Sbjct: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321

Query: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258
              EF+ +LL AE+A  GY+   +   +S+FQAM   ++++  G  +LEAQIA+GG+IDP 
Sbjct: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381

Query: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318
               R+P +IA ++G  N  + + L +PS +T+ F +PN ++ L Y +L   C+ D E+  
Sbjct: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441

Query: 2319 FLFPFGERN----ISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY 2374
             L P  E+      S  N  +  R+ +VD +T  E++V EA+++ LI+   + EL  Q+ 
Sbjct: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQEC 2501

Query: 2375 QWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-- 2432
            +W+E     S G +  +L D KTG  ++I +AI++G +D+    +Y+ G ++LT+ AD  
Sbjct: 2502 EWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 2561

Query: 2433 -----------------------------SLLSRLVPKKDL-------------HSPVAG 2450
                                         S +S +   ++L              SP+A 
Sbjct: 2562 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621

Query: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510
             + T + E+IS+ +   R +VD IT  R LEAQ  TGGII P TG+K  + +A+ +G++D
Sbjct: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681

Query: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570
            +  A +L+  +    G       K MS  EAV    +  E G R LEFQYLTGGL++P+V
Sbjct: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741

Query: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630
            H R+S EEA++ G ID   A +L+D  SY + + CP+TK K++YK+A+ ++  +  TGL+
Sbjct: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801

Query: 2631 LLEVSEPLMTGISSLYYSS 2649
            LLE +     G+ S Y  S
Sbjct: 2802 LLEAASVSSKGLPSPYNMS 2820



 Score =  124 bits (311), Expect = 1e-27
 Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 12/289 (4%)

Query: 2362 EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKK-Y 2420
            E    LE    +YQ +E        + SH  T T+     + ++ +  G   K    + Y
Sbjct: 1923 ETQSQLETERSRYQ-REIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1981

Query: 2421 QEGLITLTELADSLLSRLVPKKDLHSPV------AGYWLTASG---ERISVLKASRRNLV 2471
            +  LI  T L D LL      +++ S +      AG    AS    E+ S+++A R+ L+
Sbjct: 1982 ECQLIDKTTL-DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 2040

Query: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531
               + +  LEAQ +TGGIIDP   +K  V  A+ R L+D    QQ+   E  ITG   P 
Sbjct: 2041 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 2100

Query: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591
            + K +SV EA+  N+I++E G+R LE Q  +GG+++P     L  + AL  G+ID  +  
Sbjct: 2101 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 2160

Query: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640
             L D +   +N + P TK+K++Y +  E+   + HTGL LL V +  M+
Sbjct: 2161 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMS 2209


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190

Query: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250

Query: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310

Query: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 523 RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMI 582

Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 583 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620



 Score = 35.0 bits (79), Expect = 0.98
 Identities = 62/264 (23%), Positives = 103/264 (39%), Gaps = 44/264 (16%)

Query: 1351 GLQQ--EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408
            GL Q  E  + K E  +    +L+ A R A +D          LQ  K  +  KARL   
Sbjct: 693  GLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL----DLQYAKLLNSSKARLRS- 747

Query: 1409 KLDETNNTLRCLKLEL---ERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465
             L+  ++ +     EL     K++ E G+        R  N T  K     +  S L + 
Sbjct: 748  -LESLHSFVAAATKELMWLNEKEEEEVGFDWS----DRNTNMTAKK-----ESYSALMR- 796

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525
                  ELE    +  +LQ   DR+ R    A   ++   + + +    +    LQ+C  
Sbjct: 797  ------ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT----QWSWMLQLCCC 846

Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNEC--------AEMLKQKVE 1577
               HLKE    ++ Q   +++   E   ++Q+L E L + N C         E L Q  +
Sbjct: 847  IEAHLKEN--AAYFQFFSDVR---EAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQ 901

Query: 1578 ELTRQNNETKLMMQRIQAESENIV 1601
            +   Q NE K  +  +   ++ +V
Sbjct: 902  DEKEQLNEYKGHLSGLAKRAKAVV 925



 Score = 35.0 bits (79), Expect = 0.98
 Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 11/115 (9%)

Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP-------KVREAAENELR 1173
            ++L+  +  + E   +   + ELE   A LKK +++ E + P       ++R A E   R
Sbjct: 1236 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295

Query: 1174 KQQRNVE-DISLQKIRAESEAKQYRRELETIVREKEAAERELERV-RQLTIEAEA 1226
             QQR+ E D+ +++ R      Q     + ++ + +  +RELE++ RQL    E+
Sbjct: 1296 LQQRHGERDVEVERWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES 1348



 Score = 33.9 bits (76), Expect = 2.2
 Identities = 100/453 (22%), Positives = 170/453 (37%), Gaps = 85/453 (18%)

Query: 937  KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY-----RDTYHPLDDWI--------QQV 983
            + + L++  Q+   Q++     L G+ K  K       R   HP+   +        +QV
Sbjct: 892  RLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV 951

Query: 984  ETTQRKIQE------NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK 1037
            E T  K  E       QP + K L++    +  + S   +      E Q+   +  A  +
Sbjct: 952  EVTVHKGDECQLVGPAQPSHWKVLSSS-GSEAAVPSVCFLVPPPNQEVQEAVTRLEA--Q 1008

Query: 1038 DYELQTMTYRAMVDSQQKSPVK--RRRMQSSADLIIQEFMDLRT--RYTALVTLMTQYIK 1093
               L T+ ++  VD +     +  RR +Q      +  F  L+   +  AL +L   Y  
Sbjct: 1009 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 1068

Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGA----YSDLLQRQKATVLENSKLTGKISELERMVAE 1149
            F  DS          R     E+G+    Y  LLQ  +    E S+    ISEL+ +  +
Sbjct: 1069 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1128

Query: 1150 LKKQKSRVEEEL------PKVREAAEN--ELRKQQRNVEDISLQKIRAESEAKQ------ 1195
            L+  ++R    L         RE A+   E +K Q  VE +     R  +EA++      
Sbjct: 1129 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188

Query: 1196 ----------------------------YRRELETI---VREKEAAERELERVRQLTIEA 1224
                                        Y  +L+TI   +R  + AE  L    +   EA
Sbjct: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248

Query: 1225 EAKRAAVEE------NLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELR 1278
            +A  A + E      +L   R Q E    T   L D L+        L+Q+  +   E+ 
Sbjct: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308

Query: 1279 RKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKE 1311
            R R   E + +L+++ +  LA Q  V +++L++
Sbjct: 1309 RWR---ERVAQLLERWQAVLA-QTDVRQRELEQ 1337


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score =  606 bits (1562), Expect = e-172
 Identities = 368/1259 (29%), Positives = 657/1259 (52%), Gaps = 139/1259 (11%)

Query: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291

Query: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651

Query: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711

Query: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767

Query: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827

Query: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887

Query: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947

Query: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007

Query: 1086 TLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELER 1145
            T    Y +F  + LK LE+ ++K                        N+K+         
Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLK------------------------NTKI--------- 1034

Query: 1146 MVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVR 1205
                       +EEEL   R+A      K +    D +LQK +A  E  Q++ +L ++  
Sbjct: 1035 ---------EVLEEELRLARDANSENCNKNK--FLDQNLQKYQA--ECSQFKAKLASLEE 1081

Query: 1206 EKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLND 1265
             K  AE + +  +Q   +   +   + E +     ++E+    R+++ED           
Sbjct: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---------- 1131

Query: 1266 LEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITE 1325
             +QQKN   ++L++ R  E+E          +L +QK  +EK +KEK+  E+E  R + +
Sbjct: 1132 FDQQKND-YDQLQKARQCEKE----------NLGWQKLESEKAIKEKE-YEIERLRVLLQ 1179

Query: 1326 IQYTCR---ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382
             + T +   EN L           +A   +Q+   K +  ++ Q+ + L    +  EQD 
Sbjct: 1180 EEGTRKREYENEL----------AKASNRIQE--SKNQCTQVVQERESLLVKIKVLEQDK 1227

Query: 1383 RELTYELNALQLEKTSSEEKARL---LKDKLDETNNTLRCLKLELERKDQAEKGYSQQLR 1439
              L    + L   K++ E + R+   L+ +  +  N L   K +  RK++A +    +  
Sbjct: 1228 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287

Query: 1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE--------SLNHEKGKLQREVDRI 1490
            +  R+ N    + E    E   +K+I+   + +LE         L  E+ + QRE+D++
Sbjct: 1288 KSEREKNSLRSEIERLQAE---IKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343



 Score =  377 bits (969), Expect = e-104
 Identities = 218/619 (35%), Positives = 346/619 (55%), Gaps = 50/619 (8%)

Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIA 2140
            SV+     FQG+R  VT  +LV++ +L   T+ +L  G  + +EV + +  FL  ++ IA
Sbjct: 1603 SVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 1662

Query: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200
            G+Y E+TK+K+    A +  ++    AL  LEAQAATGFI+DP+S     VE+A  +G+V
Sbjct: 1663 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 1722

Query: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258
              EF+ +LL AE+A  GY+   +   +S+FQAM   ++++  G  +LEAQIA+GG+IDP 
Sbjct: 1723 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 1782

Query: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318
               R+P +IA ++G  N  + + L +PS +T+ F +PN ++ L Y +L   C+ D E+  
Sbjct: 1783 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 1842

Query: 2319 FLFPFGERN----ISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY 2374
             L P  E+      S  N  +  R+ +VD +T  E++V EA+++ LI+   + EL  Q+ 
Sbjct: 1843 CLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQEC 1902

Query: 2375 QWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-- 2432
            +W+E     S G +  +L D KTG  ++I +AI++G +D+    +Y+ G ++LT+ AD  
Sbjct: 1903 EWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 1962

Query: 2433 -----------------------------SLLSRLVPKKDL-------------HSPVAG 2450
                                         S +S +   ++L              SP+A 
Sbjct: 1963 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2022

Query: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510
             + T + E+IS+ +   R +VD IT  R LEAQ  TGGII P TG+K  + +A+ +G++D
Sbjct: 2023 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2082

Query: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570
            +  A +L+  +    G       K MS  EAV    +  E G R LEFQYLTGGL++P+V
Sbjct: 2083 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2142

Query: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630
            H R+S EEA++ G ID   A +L+D  SY + + CP+TK K++YK+A+ ++  +  TGL+
Sbjct: 2143 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2202

Query: 2631 LLEVSEPLMTGISSLYYSS 2649
            LLE +     G+ S Y  S
Sbjct: 2203 LLEAASVSSKGLPSPYNMS 2221



 Score =  235 bits (599), Expect = 5e-61
 Identities = 306/1402 (21%), Positives = 578/1402 (41%), Gaps = 247/1402 (17%)

Query: 1296 KDLAFQKQVAEKQLKEKQK----IELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351
            +D+   K +   +  +KQ+    +EL+  R+  +I++      L   P+    S   +T 
Sbjct: 647  QDVNHNKVIETNRENDKQETWMLMELQKIRR--QIEHCEGRMTLKNLPLADQGSSHHITV 704

Query: 1352 LQQE-----HDKQKAEELKQQVDELTAANRKAEQ---------DMRELTYELNALQLEKT 1397
               E     +D Q   E+  Q+ ++ A  R +E+          + +    +N +     
Sbjct: 705  KINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL 764

Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQA------EKGYSQQLRELGRQLNQTTGK 1451
            +S    R L   + +T + L+  +  L  ++         + Y   L+++   LN     
Sbjct: 765  NSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSL 824

Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQH----LNSQ 1507
                  E    ++I      +    + + GK   +V ++T      +K I      L  Q
Sbjct: 825  LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ 884

Query: 1508 IHSFRDEKE-----LERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL 1562
            I   R+ ++      + L   +R+ D L+         +++ +  +K  + +I    ++ 
Sbjct: 885  IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944

Query: 1563 EKSNECAEMLKQKVEELTRQ------NNETKLMMQ----RIQAESENIVLEKQTIQQR-C 1611
            E+  + AE+    +++   Q        ET L +      IQ+ S  I+ E   +  R  
Sbjct: 945  EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004

Query: 1612 EALKIQADGFK---DQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCD 1668
            E L    D ++   + L+S  +   K TK        I+ LEE+L  +++  SE    C+
Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTK--------IEVLEEELRLARDANSE---NCN 1053

Query: 1669 QQNIIIQNTKK---EVRNLNAELNASKEEKRRGE-------QKVQLQQAQVQELNNRLKK 1718
            +   + QN +K   E     A+L + +E KR+ E       Q +     Q++ELN ++ +
Sbjct: 1054 KNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113

Query: 1719 VQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLD 1778
            +  E     IE++   RK V       +F Q   ++    ++L +++   + ++   +L+
Sbjct: 1114 LTYE-----IEDEKRRRKSV-----EDRFDQQKNDY----DQLQKARQCEKENLGWQKLE 1159

Query: 1779 FVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQ 1838
                              E  IKE E ++++ R  +Q+          + ++ E+EL   
Sbjct: 1160 -----------------SEKAIKEKEYEIERLRVLLQE-------EGTRKREYENELAKA 1195

Query: 1839 KREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSR 1898
               ++  K +  Q ++E E  LV ++   Q K+  +        E  +   + + E  +R
Sbjct: 1196 SNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR------LEDELNRAKSTLEAETR 1249

Query: 1899 NTGHLHPTPR---SPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCY 1955
                L    +   + L +W         K Q+   E+  ++++        E+EKS++  
Sbjct: 1250 VKQRLECEKQQIQNDLNQW---------KTQYSRKEEAIRKIES-------EREKSEREK 1293

Query: 1956 SEYFSQTSTELQITFDETNPITRL-SEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTP 2014
            +   S+              I RL +EI++I ++         R   +  E E  +    
Sbjct: 1294 NSLRSE--------------IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1339

Query: 2015 LEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNF 2074
            ++  + + Y  H E  T            EW                             
Sbjct: 1340 IDKLRQRPYGSHRETQT----------ECEW----------------------------- 1360

Query: 2075 DGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLT 2134
                  +V   +  F GLR  VTA QL E +L+D  T+++L  G K+VEEV   +  FL 
Sbjct: 1361 ------TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR 1414

Query: 2135 KATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDA 2194
             A SIAG    S KEK S   A  + +I     +  LEAQAATG IIDP   +  +V+ A
Sbjct: 1415 GAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSA 1473

Query: 2195 VLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASG 2252
            + + ++D + R ++  AEKA  G+   +S KT+SV +A++  ++DR+ G  +LEAQIASG
Sbjct: 1474 IARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASG 1533

Query: 2253 GVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVF 2312
            GV+DPV  + +P ++AL +GL++  + + L++P  + + F +P  K+ + Y +L   C  
Sbjct: 1534 GVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRI 1593

Query: 2313 DVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQ 2372
            +  +   L    +R++S   +++              +TV E     ++  S   EL   
Sbjct: 1594 EPHTGLLLLSVQKRSMSFQGIRQ-------------PVTVTELVDSGILRPSTVNELESG 1640

Query: 2373 QYQWKEA-----MFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITL 2427
            Q  + E       F +     + +  +T T     I EA++ G +      +  E     
Sbjct: 1641 QISYDEVGERIKDFLQGSSCIAGIYNET-TKQKLGIYEAMKIGLVRPGTALELLEAQAAT 1699

Query: 2428 TELADSLLSRLVPKKDLHS-----------------PVAGYWLTASGERISVLKASRRNL 2470
              + D + +  +P ++ +                   V GY    +G  IS+ +A  + L
Sbjct: 1700 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 1759

Query: 2471 VDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHP 2530
            +++   +R LEAQ++TGGIIDP    +  V  A  RG  +E  ++ L        G   P
Sbjct: 1760 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 1819

Query: 2531 ITNKMMSVVEAVNANIINKEMGIRCLEF-----QYLTGG----------LIEPQVHSRLS 2575
             T + ++ ++     I ++E G+  L       Q  T            +++P+ +  +S
Sbjct: 1820 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 1879

Query: 2576 IEEALQVGIIDVLIATKLKDQK 2597
            ++EA + G+ID     +L +Q+
Sbjct: 1880 VQEAYKKGLIDYETFKELCEQE 1901



 Score =  124 bits (311), Expect = 1e-27
 Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 12/289 (4%)

Query: 2362 EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKK-Y 2420
            E    LE    +YQ +E        + SH  T T+     + ++ +  G   K    + Y
Sbjct: 1324 ETQSQLETERSRYQ-REIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1382

Query: 2421 QEGLITLTELADSLLSRLVPKKDLHSPV------AGYWLTASG---ERISVLKASRRNLV 2471
            +  LI  T L D LL      +++ S +      AG    AS    E+ S+++A R+ L+
Sbjct: 1383 ECQLIDKTTL-DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 1441

Query: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531
               + +  LEAQ +TGGIIDP   +K  V  A+ R L+D    QQ+   E  ITG   P 
Sbjct: 1442 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 1501

Query: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591
            + K +SV EA+  N+I++E G+R LE Q  +GG+++P     L  + AL  G+ID  +  
Sbjct: 1502 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 1561

Query: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640
             L D +   +N + P TK+K++Y +  E+   + HTGL LL V +  M+
Sbjct: 1562 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMS 1610



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 124/635 (19%), Positives = 259/635 (40%), Gaps = 112/635 (17%)

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
            +DS ES  F  S+     + +N  K  + E+    ++ E+ + +  L  + +++  L+L 
Sbjct: 909  QDSLESMKFGDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966

Query: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
            +    L   +  P++R  + +S   +  QE        +  +L T +     F S+   S
Sbjct: 967  SYTSGLETLLNIPIKRTMI-QSPSGVILQEAADVHARYI--ELLTRSGDYYRFLSEMLKS 1023

Query: 815  SSVPTLRS-ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA--AEALVKLYETKLCE 871
                 L++ ++ V+ + +      +S   +K K ++  L+  QA  ++   KL   +  +
Sbjct: 1024 LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931
             +A +  K+  +NL     Q +   ++  ++ + +EDE ++ K++ D            F
Sbjct: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR-----------F 1132

Query: 932  DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
            D  K   DQL +  Q     +  +  + E   K  +Y  +    L   +Q+  T +R+ +
Sbjct: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYE 1189

Query: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051
                + S  +    NQ   +V E E    K+    K  EQ  A ++  E +    ++ ++
Sbjct: 1190 NELAKASNRIQESKNQCTQVVQERESLLVKI----KVLEQDKARLQRLEDELNRAKSTLE 1245

Query: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK 1111
            ++ +    ++R++     I  +    +T+Y+                    +EE I++ +
Sbjct: 1246 AETRV---KQRLECEKQQIQNDLNQWKTQYSR-------------------KEEAIRKIE 1283

Query: 1112 ETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENE 1171
                        +R+K+   +NS      SE+ER+ AE+K    R+EE   + R   E+ 
Sbjct: 1284 S-----------EREKSEREKNSLR----SEIERLQAEIK----RIEE---RCRRKLEDS 1321

Query: 1172 LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAV 1231
             R+ Q  +E          +E  +Y+RE++ + +    + RE +   + T++        
Sbjct: 1322 TRETQSQLE----------TERSRYQREIDKLRQRPYGSHRETQTECEWTVD-------- 1363

Query: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQ---KNKLMEELRRKRDNEEELL 1288
                            T + + D L++K  ++   E Q   K  L + L+ K+  EE   
Sbjct: 1364 ----------------TSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE--- 1404

Query: 1289 KLIKQMEKDLAFQKQVAEKQLKEKQKIEL-EARRK 1322
             +  +++  L     +A      K+K  L EA+RK
Sbjct: 1405 -VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRK 1438



 Score = 37.4 bits (85), Expect = 0.20
 Identities = 58/248 (23%), Positives = 111/248 (44%), Gaps = 48/248 (19%)

Query: 1502 QHLNSQ--IH-SFRDEK-ELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQR 1557
            QH+NS   IH S  D + +L++++   R+   +  Q E+ +E LL   KA  E  D +++
Sbjct: 216  QHINSHRGIHNSIGDYRWQLDKIKADLREKSAIY-QLEEEYENLL---KASFERMDHLRQ 271

Query: 1558 LNEELEKS-------NECAEM------------LKQKVEELTRQNNETKLM---MQRIQA 1595
            L   ++ +       N+C E             + QK E  + + ++ ++    + +++ 
Sbjct: 272  LQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQ 331

Query: 1596 ESENIVLEKQTIQQRCEA----LKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEE 1651
            ES+ +VL +     + EA    L+ Q        +  + HL +     Q F+ + +  E 
Sbjct: 332  ESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFE-EAQSTEA 390

Query: 1652 DLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQE 1711
             L   Q+ + + K  CD+ N+ +Q+  ++++ L  E     E KR           QVQ 
Sbjct: 391  YLKGLQDSIRK-KYPCDK-NMPLQHLLEQIKELEKEREKILEYKR-----------QVQN 437

Query: 1712 LNNRLKKV 1719
            L N+ KK+
Sbjct: 438  LVNKSKKI 445


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  372 bits (956), Expect = e-102
 Identities = 371/1644 (22%), Positives = 744/1644 (45%), Gaps = 194/1644 (11%)

Query: 279  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 335
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186

Query: 336  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 395
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235

Query: 396  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295

Query: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354

Query: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412

Query: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471

Query: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528

Query: 755  NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 813
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579

Query: 814  SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 873
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639

Query: 874  AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 933
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699

Query: 934  HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 993
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755

Query: 994  QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1051
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815

Query: 1052 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-EIKR 1109
              +     KR R+QS A  + +E   L  ++T +  +  Q ++    +L  L ++ E++ 
Sbjct: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875

Query: 1110 CKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAE 1169
              ET +         R  + V E  K+  ++ E      +L+ +    +EE+  +R    
Sbjct: 876  THETLQR-------NRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGP 928

Query: 1170 NE-------LRKQQRNVEDISLQKIRAESEAKQYR-----RELETIVREKEAAEREL--- 1214
             E       L+K    V + S Q+++     +Q++      ELE +  +  A E+E    
Sbjct: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988

Query: 1215 --ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNK 1272
              E V +  +  E  RA  +E +L  R +LE     +   E  +      +  L ++K++
Sbjct: 989  GQEYVVKEVLRIEPDRAQADE-VLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSR 1047

Query: 1273 LMEELRRKR----DNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQY 1328
              E++  K      N+ +L    +Q+++D   Q Q+ EKQ  E++   L+ + K  E + 
Sbjct: 1048 AQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQ--EEELSFLQDKLKRLEKER 1105

Query: 1329 TCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYE 1388
               E  + V  + +     A         +++  +L +Q ++  A  R ++++  EL  +
Sbjct: 1106 AMAEGKITVKEVLKVEKDAAT--------EREVSDLTRQYEDEAAKARASQREKTELLRK 1157

Query: 1389 LNALQLE--KTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN 1446
            + AL+ E  K   +EK R +     +  + +  L+LEL  +++  +G  +QLR    +L 
Sbjct: 1158 IWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELE 1217

Query: 1447 --QTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL 1504
              +  G   E  +   ++ K K + ++E      E  +L+ E+   TR     +  I  L
Sbjct: 1218 ALRRRGPQVEVKEVTKEVIKYKTDPEME-----KELQRLREEIVDKTRLIERCDLEIYQL 1272

Query: 1505 NSQIHSFRDEK-ELERLQICQ-----RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRL 1558
              +I + +D K +++  ++ Q     ++    KE+      +L +  K + +   +    
Sbjct: 1273 KKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQ 1332

Query: 1559 NEELEKSNECAEMLKQKV--EELTRQNNETKLMMQRIQAESENIVLEKQTIQQ-RCEALK 1615
             E++ +  E    +K++V  +E+ R   E  L  +   A +E+I +E + I + R E  +
Sbjct: 1333 EEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAE-ASAFAESIDVELRQIDKLRAELRR 1391

Query: 1616 IQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQ-QNIII 1674
            +Q    + +L    E L ++ +  ++ +R+++ L++ LA  +   +E ++K    Q +++
Sbjct: 1392 LQRR--RTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVL 1449

Query: 1675 QNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTH 1734
            Q   ++ R  +A L    EE+   + + QL + +++ L  +         L  +E+    
Sbjct: 1450 QQDPQQARE-HALLRLQLEEE---QHRRQLLEGELETLRRK---------LAALEKAEVK 1496

Query: 1735 RKMVL---FQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQE 1791
             K+VL    Q E G  +Q  +  +  +E+   SK   + ++S +      L+  NS++ +
Sbjct: 1497 EKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556

Query: 1792 NAK-LCETNIK-ELERQ-LQQYREQMQQGQHMEANHYQKCQKL---------EDELIAQK 1839
                L E N K +LERQ LQ    ++Q   +M A   +  + +         +  L + +
Sbjct: 1557 ELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLE 1616

Query: 1840 REVENLK---QKMDQQIKEHEHQL 1860
            RE+++LK   +  D +I E + +L
Sbjct: 1617 RELDDLKRLSKDKDLEIDELQKRL 1640



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 163/846 (19%), Positives = 350/846 (41%), Gaps = 117/846 (13%)

Query: 725  LLKSAEREEQEESVYNLYISEVRNI-RLRLENCEDRLIRQIRTPLERDDLHESVFR---- 779
            L   A + ++EE+      +EV  I R RL+N E  L   +R   E +  HE++ R    
Sbjct: 828  LQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFAL-NLLRQQPEVEVTHETLQRNRPD 886

Query: 780  --ITEQEKLKKELE-------RLKDDLGTITNKCEEFFSQAAASSSV----------PTL 820
              + E  K++KEL+       +L++++ +   +     +Q    S V          P L
Sbjct: 887  SGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVL 946

Query: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQ------AAEALVK---LYETKLCE 871
                  + + + +    +    ++L+ + L L+  +        E +VK     E    +
Sbjct: 947  EESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQ 1006

Query: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA--KAISDEMFKTYKERDL 929
             + V+  +  +E L        +EV   +Q   AL +E  +A  K    E+ K   +  L
Sbjct: 1007 ADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL 1066

Query: 930  DFDWHK-----EKADQLVERWQNVHVQIDNRLRDLEG----------IGKSLKYYRD--T 972
            + ++ +     ++ DQL E+ +     + ++L+ LE           + + LK  +D  T
Sbjct: 1067 EAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT 1126

Query: 973  YHPLDDWIQQVETTQRKIQENQPENSKTL----ATQLNQQKMLVSEIEMK--------QS 1020
               + D  +Q E    K + +Q E ++ L    A +    K++V E   +        +S
Sbjct: 1127 EREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAES 1186

Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT- 1079
            ++   +    +     +  E Q  +Y++ +++     ++RR  Q     + +E +  +T 
Sbjct: 1187 EVANLRLELVEQERKYRGAEEQLRSYQSELEA-----LRRRGPQVEVKEVTKEVIKYKTD 1241

Query: 1080 --------RYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQR------ 1125
                    R    +   T+ I+     + +L++E I+  K+T       +++Q       
Sbjct: 1242 PEMEKELQRLREEIVDKTRLIERCDLEIYQLKKE-IQALKDTKPQVQTKEVVQEILQFQE 1300

Query: 1126 QKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQ 1185
               T  E + L  K+SE ++   +L+++++  EE++ +     E EL + +  V  +  +
Sbjct: 1301 DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIAR----KEEELSRVKERV--VQQE 1354

Query: 1186 KIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEEN 1245
             +R E E    R E        +   R+++++R      + +R  +E  L     +LE  
Sbjct: 1355 VVRYEEEPG-LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQL----EELERE 1409

Query: 1246 TFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVA 1305
               RR  E  ++R    L  LEQ++ +  E++   +       K++ Q +   A +  + 
Sbjct: 1410 RQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQ-------KVVLQQDPQQAREHALL 1462

Query: 1306 EKQLKEKQKIELEARRKITEIQY-TCREN--ALPVCPITQATSCRAVTGLQQEHDKQKAE 1362
              QL+E+Q      RR++ E +  T R    AL    + +         +++   +Q+ +
Sbjct: 1463 RLQLEEEQH-----RRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQ 1517

Query: 1363 ELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKL 1422
             LK  ++E + + R+ + ++  L   L+ L+   + S ++   L+++  +     + L+L
Sbjct: 1518 RLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQL 1577

Query: 1423 ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAM-----QEASDLKKIKRNYQLELESLN 1477
            E  R        + + R+L       +G   ++      +E  DLK++ ++  LE++ L 
Sbjct: 1578 ETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQ 1637

Query: 1478 HEKGKL 1483
               G +
Sbjct: 1638 KRLGSV 1643



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 8/114 (7%)

Query: 2325 ERNISNLNVKKTHR-------ISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWK 2377
            ++ + ++ VK+  R       I V+   TG EL+  EA +  LI+ +++++L  Q+  W+
Sbjct: 1637 QKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWE 1696

Query: 2378 EAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELA 2431
            E       G SS ++ D K+G  F+I EA++ G +  A   +Y    +++ ELA
Sbjct: 1697 EISVKGPNGESS-VIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELA 1749


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score =  300 bits (769), Expect = 1e-80
 Identities = 423/2094 (20%), Positives = 846/2094 (40%), Gaps = 297/2094 (14%)

Query: 289  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 348
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206

Query: 349  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261

Query: 409  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 467
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321

Query: 468  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 527
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381

Query: 528  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 587
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439

Query: 588  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 647
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481

Query: 648  KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 707
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 482  -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518

Query: 708  ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 767
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552

Query: 768  LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612

Query: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672

Query: 887  STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 946
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732

Query: 947  NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788

Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1065
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848

Query: 1066 SADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL 1122
              + I  +  +L   YT +      + Q ++FA   L++ E  E  R    ++ G+ S  
Sbjct: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPA 908

Query: 1123 LQRQKATVLENSKLTGKISELERMVAELKKQKS-----RVEEELPKVREAAENELRKQQR 1177
               +++  L+ ++L  +   + R+  EL+ Q+S     R +  L ++ E    E  +  +
Sbjct: 909  QAGRESEALK-AQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQ 967

Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
                +S  K + E E K+           +   + +LE   Q  ++ E+KR  ++ +LL 
Sbjct: 968  LEGSLSRVKAQVEEEGKR-----------RAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016

Query: 1238 FR-------NQLEENTFTRRTLEDHLKRKDLSLN-DLEQQKNKLMEELRRKRD-NEEELL 1288
                       L+      R     L+ +D  ++  LE  K +L+   +R+ D  E+ ++
Sbjct: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076

Query: 1289 KLIKQMEKDLAFQK--QVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSC 1346
            K + ++EK+L   K  Q    Q++E      +A   + ++Q    +    +  +      
Sbjct: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIV 1136

Query: 1347 RAVTGLQQEHD-KQKAEELKQQVDELTAANRKAEQDMREL--TYELNALQLEKTSSEEKA 1403
            + V  ++Q+    Q++  L+  ++E    N    +++ +L   Y +   Q  K   +E+ 
Sbjct: 1137 KEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERV 1196

Query: 1404 RLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK 1463
              +     ET   +  LK +L+       G  +++ +L   L     +A++   E  ++ 
Sbjct: 1197 HEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVL--RAQKPTVEYKEVT 1254

Query: 1464 KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEK-ELERLQI 1522
            +    ++   E L  E  +L+ +++ +  +H  +++ +  L  +   +R E+ ++E   +
Sbjct: 1255 QEVVRHERSPEVL-REIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313

Query: 1523 CQRKSDHLKEQ-FEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQK----VE 1577
             +    H K+   EK  E+L Q ++   +     +    EL+      E  K +    V+
Sbjct: 1314 SKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQ 1373

Query: 1578 ELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637
            E+     + KL  +  +       L+++  ++R   L++Q      QLR+  E       
Sbjct: 1374 EVVVTQKDPKLREEHSRLSGS---LDEEVGRRRQLELEVQ------QLRAGVEEQEGLLS 1424

Query: 1638 TEQDFQRKIKCLEEDLAKSQNLVSEFKQK--CDQQNIIIQNTKKEVRNLNAELNASKEEK 1695
             ++D  +K+  +E +L +    + E +++    Q+ II++   K  +  + +L  S E  
Sbjct: 1425 FQEDRSKKL-AVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK--DPDLEKSTEAL 1481

Query: 1696 RRGEQKVQLQQAQVQELNNRLKKVQ---DELHLKTIEEQMTHRKMVLFQEESGKFKQSAE 1752
            R     +  ++ QV ELN   K +Q   D L     +E+  +++++  Q++     +  E
Sbjct: 1482 R---WDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD-----RVLE 1533

Query: 1753 EFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCET---NIKELERQLQQ 1809
            + R ++ +++  +          R    + ++E  R +E     ET        E +LQ+
Sbjct: 1534 DERARVWEMLNRE----------RTARQAREEEARRLRERIDRAETLGRTWSREESELQR 1583

Query: 1810 YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQK 1869
             R+Q            Q+C +L+ EL    R +E  KQ+   Q++E E +L+  + E ++
Sbjct: 1584 ARDQAD----------QECGRLQQEL----RALERQKQQQTLQLQE-ESKLLSQKTESER 1628

Query: 1870 KSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRV 1929
            +                K  Q   ELS                    E   L EK Q   
Sbjct: 1629 Q----------------KAAQRGQELS------------------RLEAAILREKDQIYE 1654

Query: 1930 VEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQA 1989
             E+  +++      A + +E+  Q      +  ST++ I   ET     +S  E  +   
Sbjct: 1655 KERTLRDLH-----AKVSREELSQETQTRETNLSTKISILEPETG--KDMSPYEAYKRGI 1707

Query: 1990 LNNSRPPVRYQDNACEMELVKVLTP-------LEIAKNKQYDMHTEVTTLKQEKNP---- 2038
            ++  +  ++ Q+  C+ E V    P       L+    KQY +   +   +  K      
Sbjct: 1708 IDRGQ-YLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLY 1766

Query: 2039 ----VPSAEEWMLEG--CRASGGLKKGDFLKK----GLEPETFQNFDGDHACSVRDDEFK 2088
                +P +E  +L     + S  L  G  + K       P++   F    +  + DD F 
Sbjct: 1767 KDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFP 1826

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTK 2148
              G+  T T  +      +    ++ +            T  K L    +  G+    ++
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPI------------TGQKLLEAQAATGGIVDLLSR 1874

Query: 2149 EKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208
            E+ S   A ER +I+       L AQ A   I DP++ +  SV +AV KG          
Sbjct: 1875 ERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKG---------- 1924

Query: 2209 LEAEKAAVGYSYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIA 2268
                                       + R+     L+ Q  +GG+IDP R  R+P + A
Sbjct: 1925 --------------------------WMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQA 1958

Query: 2269 LQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFP 2322
            L  G+++  + Q L + SS  +   +P +K+ L Y E +  C  D  S   L P
Sbjct: 1959 LLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012



 Score =  192 bits (489), Expect = 3e-48
 Identities = 332/1571 (21%), Positives = 650/1571 (41%), Gaps = 242/1571 (15%)

Query: 1134 SKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEA 1193
            + +  K S+++ ++  L  +K++   +L +  + A+  +R  +  +  +    I AE  A
Sbjct: 611  NSVKNKFSDVQ-VLCSLYGEKAKAALDLERQIQDADRVIRGFEATL--VQEAPIPAEPGA 667

Query: 1194 KQYR-RELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTL 1252
             Q R  EL+   RE    +  + R+ +    +E   AA++ N   F   L       R L
Sbjct: 668  LQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRAL 727

Query: 1253 ED--HLKRKDLSLNDLEQQKNKLM-EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQL 1309
             D  H     L L +   Q   L  ++ +  +DN    L+ + +         QV     
Sbjct: 728  TDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPR--------SQVRPSDG 779

Query: 1310 KEKQKIELEARRKIT-EIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQV 1368
              +   +L+A++++T EIQ   R+ A      T +   +A+    Q+++ Q A+  +  +
Sbjct: 780  PSQIAYKLQAQKRLTQEIQSRERDRA------TASHLSQALQAALQDYELQ-ADTYRCSL 832

Query: 1369 DELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKD 1428
            +   A +      +  L   + A +     +  +    + +L +        +LE  RK 
Sbjct: 833  EPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQ--------QLEFARKM 884

Query: 1429 QAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVD 1488
              +K  S+ +R           +  +A Q +    +  R    E E+L   K +L+ E  
Sbjct: 885  LEKKELSEDIR-----------RTHDAKQGSESPAQAGR----ESEAL---KAQLEEERK 926

Query: 1489 RITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAE 1548
            R+ R     +  ++   SQ+   R ++ LERL+  +    +   Q E S    L  +KA+
Sbjct: 927  RVARV----QHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGS----LSRVKAQ 978

Query: 1549 KENNDKIQR-LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTI 1607
             E   K +  L  +LE + +    L+ K     R+  +  L+ + +     +  L+ Q  
Sbjct: 979  VEEEGKRRAGLQADLEVAAQKVVQLESK-----RKTMQPHLLTKEVTQVERDPGLDSQAA 1033

Query: 1608 QQRCEALKIQADG--FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665
            Q R +  +++ +      +L    + L    K E D + K+  ++E +   +NL      
Sbjct: 1034 QLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKV-VVKEVVKVEKNL------ 1086

Query: 1666 KCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725
                         K  + L  ++      +++ E+ V   QA++++L   +  V+ ++ +
Sbjct: 1087 ----------EMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIV 1136

Query: 1726 KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQE 1785
            K +++          +++ G  ++S+     ++  L+E                   ++ 
Sbjct: 1137 KEVKK---------VEQDPGLLQESS-----RLRSLLE-------------------EER 1163

Query: 1786 NSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENL 1845
               A    +L + + K    + Q+ + Q+Q+  H     +Q   + E E+   K +++ +
Sbjct: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVH---EIFQVDPETEQEITRLKAKLQEM 1220

Query: 1846 KQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHP 1905
              K     KE E  L  L+    +K T +   +K   E+T +  +H              
Sbjct: 1221 AGKRSGVEKEVEKLLPDLEVLRAQKPTVE---YK---EVTQEVVRHE------------- 1261

Query: 1906 TPRSPLLRWTQEPQPLEE--KWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTS 1963
                      + P+ L E  + + ++ E +    + Q     L+ E+ +        +T 
Sbjct: 1262 ----------RSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETK 1311

Query: 1964 T-ELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQ 2022
            T   ++   E +P+    E E++R +    ++     +D   E++  ++L  LE  K ++
Sbjct: 1312 TVSKEVVRHEKDPVLE-KEAERLRQEVREAAQKRRAAEDAVYELQSKRLL--LERRKPEE 1368

Query: 2023 YDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSV 2082
              +  EV   +++    P   E   E  R SG L +    ++ LE E  Q   G     V
Sbjct: 1369 KVVVQEVVVTQKD----PKLRE---EHSRLSGSLDEEVGRRRQLELEVQQLRAG-----V 1416

Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGL 2142
             + E    GL   ++ ++    KL   R + QL L ++ +E+   T+ + +     +   
Sbjct: 1417 EEQE----GL---LSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVK-- 1467

Query: 2143 YLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDP 2202
             LE   +      A    +  +   +  L  +     +   +  +  S E  + K V+  
Sbjct: 1468 -LEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526

Query: 2203 EFRIRLLEAEKAAVGYSYSSKTLSVFQAMENRM------------LDRQKGKHILEAQIA 2250
            + + R+LE E+A V +   ++  +  QA E               L R   +   E Q A
Sbjct: 1527 Q-KDRVLEDERARV-WEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA 1584

Query: 2251 SGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMC 2310
                 D   G R+  E+   +       LQ   E    ++   +   K A    EL R+ 
Sbjct: 1585 RDQA-DQECG-RLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLE 1642

Query: 2311 VFDVESQCFLFPFGERNISNLNVKKTH----------------RISVVDTKTGSELTVYE 2354
               +  +  ++   ER + +L+ K +                 +IS+++ +TG +++ YE
Sbjct: 1643 AAILREKDQIYE-KERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYE 1701

Query: 2355 AFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDK 2414
            A++R +I++  YL+L   +  W+E       G  S +L D K+G  ++I  A+    I K
Sbjct: 1702 AYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEES-VLLDRKSGKQYSIEAALRCRRISK 1760

Query: 2415 ALVKKYQEGLITLTELA----------DSL-LSRLVPKKDLHS----------------- 2446
                 Y++G + ++E A           SL +  ++ K  L S                 
Sbjct: 1761 EEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGL 1820

Query: 2447 -----PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVA 2501
                 P+AG + T +  + S+  A  +N++D IT  + LEAQ +TGGI+D L+ ++Y V 
Sbjct: 1821 GDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVH 1880

Query: 2502 EALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYL 2561
            +A+ RGL++    Q+L   +   TGI  P+T K +SV EAV    + +E  +  L+ Q+L
Sbjct: 1881 KAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHL 1940

Query: 2562 TGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKA 2621
            TGGLI+P+   R+ I++AL  G+I   +A  L+D+ SY +++  P +K +L+YKEA+ + 
Sbjct: 1941 TGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRC 2000

Query: 2622 DFDFHTGLKLL 2632
              D  +GL LL
Sbjct: 2001 RKDPLSGLLLL 2011



 Score =  113 bits (283), Expect = 2e-24
 Identities = 266/1397 (19%), Positives = 554/1397 (39%), Gaps = 186/1397 (13%)

Query: 990  IQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1049
            +QE   E  +     L QQ  ++      ++    C      +    +D   Q    RA+
Sbjct: 668  LQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRAL 727

Query: 1050 VDSQQKSPVK---RRRMQSSADLIIQEFMDLRTRYTALVTLMTQ----------YIKFAG 1096
             D       +   R ++   A L  Q+F + +   ++ +  + +           I +  
Sbjct: 728  TDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKL 787

Query: 1097 DSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI--SELERMVAELKKQK 1154
             + KRL +E   R ++ +     S  LQ      L++ +L        LE  +A    ++
Sbjct: 788  QAQKRLTQEIQSRERDRATASHLSQALQ----AALQDYELQADTYRCSLEPTLAVSAPKR 843

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQY--RRELETIVREKEAAER 1212
             RV   L +  +A E  L K    V     Q ++    A++   ++EL   +R    A++
Sbjct: 844  PRVAP-LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQ 902

Query: 1213 ELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNK 1272
              E   Q   E+EA +A +EE                       KR     ++LE Q+++
Sbjct: 903  GSESPAQAGRESEALKAQLEEER---------------------KRVARVQHELEAQRSQ 941

Query: 1273 LMEELRRKRD----NEEELLKLIK--QMEKDLAFQKQVAEKQLKEKQKIELE---ARRKI 1323
            L++ LR +R      E+E+++  +  Q+E  L+  K   E++ K +  ++ +   A +K+
Sbjct: 942  LLQ-LRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKV 1000

Query: 1324 TEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMR 1383
             +++ + R+   P     + T      GL  +     A +L+ Q+ +L   +      + 
Sbjct: 1001 VQLE-SKRKTMQPHLLTKEVTQVERDPGLDSQ-----AAQLRIQIQQLRGEDAVISARLE 1054

Query: 1384 ELTYELNALQLEKTSSEEKARLLK----DKLDETNNTLRCLKLELE----RKDQAEKGYS 1435
             L  EL AL+  +   +EK  + +    +K  E     + L+L++E    R+ QAE+  +
Sbjct: 1055 GLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVA 1114

Query: 1436 Q---QLRELGRQLNQTTGKA--EEAMQEASDLKKIKRNYQLE--LESLNHEKGKLQREVD 1488
            +   ++ +L R ++    K   +E  +   D   ++ + +L   LE    +   L RE+ 
Sbjct: 1115 KLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELS 1174

Query: 1489 RITRAHAVAEKNIQ--HLNSQIHSF-----RDEKELERLQICQRKSDHLKEQFEKSHEQL 1541
             +   ++V EK      L  ++H         E+E+ RL+   ++    +   EK  E+L
Sbjct: 1175 DLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234

Query: 1542 LQNIKAEKENNDKIQ--RLNEELEKSNECAEMLKQ------KVEELTRQNNETKLMMQRI 1593
            L +++  +     ++   + +E+ +     E+L++      ++ EL   +  ++  + R+
Sbjct: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294

Query: 1594 QAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDL 1653
            Q E +    E+  ++ +  + ++        L    E L ++ +     +R  +    +L
Sbjct: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYEL 1354

Query: 1654 AKSQNLVSEFK--QKCDQQNIIIQNTKKEVRNLNAELNASKEE----KRRGEQKVQLQQA 1707
               + L+   K  +K   Q +++     ++R  ++ L+ S +E    +R+ E +VQ  +A
Sbjct: 1355 QSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRA 1414

Query: 1708 QVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL--MESK 1765
             V+E    L   +D      +E ++  R++ L  +E  K   + +E +  ME++  +E  
Sbjct: 1415 GVEEQEGLLSFQEDRSKKLAVEREL--RQLTLRIQELEKRPPTVQE-KIIMEEVVKLEKD 1471

Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825
               E     +R D   L QE ++  E  + C+    +++  + Q  +  ++  + E    
Sbjct: 1472 PDLEKSTEALRWD---LDQEKTQVTELNRECKN--LQVQIDVLQKAKSQEKTIYKEVIRV 1526

Query: 1826 QKCQKLEDE------LIAQKREVENLKQKMDQQIKEHEHQLVLL-------QCEIQKKST 1872
            QK + LEDE      ++ ++R     +++  ++++E   +   L       + E+Q+   
Sbjct: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARD 1586

Query: 1873 AKD--C--------TFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLE 1922
              D  C          +   +    + Q   +L S+ T     + R    +  QE   LE
Sbjct: 1587 QADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKT----ESERQKAAQRGQELSRLE 1642

Query: 1923 EKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEI 1982
                    +   KE   +   A + +E+  Q      +  ST++ I   ET     +S  
Sbjct: 1643 AAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGK--DMSPY 1700

Query: 1983 EKIRDQALNNSRPPVRYQDNACEMELVKVLTP-------LEIAKNKQYDMHTEVTTLKQE 2035
            E  +   ++  +  ++ Q+  C+ E V    P       L+    KQY +   +   +  
Sbjct: 1701 EAYKRGIIDRGQY-LQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRIS 1759

Query: 2036 KNP--------VPSAEEWMLEG--CRASGGLKKGDFLKKGL----EPETFQNFDGDHACS 2081
            K          +P +E  +L     + S  L  G  + K       P++   F    +  
Sbjct: 1760 KEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLG 1819

Query: 2082 VRDDEFKFQGLRHT-------------------VTARQLVEAKLLDMRTIEQLRLGLKTV 2122
            + DD F   G+  T                   +T ++L+EA+      ++ L     +V
Sbjct: 1820 LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSV 1879

Query: 2123 EEVQK-------TLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQA 2175
             +  +       +  + L    +  G+    TK+++S   A ++  + +   L  L+ Q 
Sbjct: 1880 HKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQH 1939

Query: 2176 ATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKA---AVGYSYSSKTLSVFQAME 2232
             TG +IDP       ++ A+L G++  E   +LL+ E +    +    S + LS  +AM 
Sbjct: 1940 LTGGLIDPKRTGRIPIQQALLSGMISEEL-AQLLQDESSYEKDLTDPISKERLSYKEAMG 1998

Query: 2233 NRMLDRQKGKHILEAQI 2249
                D   G  +L A +
Sbjct: 1999 RCRKDPLSGLLLLPAAL 2015



 Score = 32.7 bits (73), Expect = 4.9
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 60  LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98

Query: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139


>gi|207452735 epiplakin 1 [Homo sapiens]
          Length = 5090

 Score =  261 bits (667), Expect = 6e-69
 Identities = 208/698 (29%), Positives = 339/698 (48%), Gaps = 70/698 (10%)

Query: 1992 NSRPPVRYQDN----ACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWML 2047
            ++R  V YQ       C+ E   +L PL      + D HT V  L+  K PV +      
Sbjct: 1407 SARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDHTAVA-LRAMKVPVSTGR---F 1462

Query: 2048 EGCRAS-GGLKKGDFLKKGLEPETFQNFDGDHACSVRDD----------------EFKFQ 2090
            +GC  S   L   +++      E         A ++R                  +  F+
Sbjct: 1463 KGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQVVSAVTALVEAAERQPLQATFR 1522

Query: 2091 GLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLESTK 2148
            GLR  V+AR L  A+L+  +T+++L  G  TV+EV +  ++ + L     IAG+ ++ T+
Sbjct: 1523 GLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVLIQGTQ 1582

Query: 2149 EKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208
            E++S   A  R I+    AL  LEAQAATGFIIDP   +  +VE+A   G+   E  ++L
Sbjct: 1583 ERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKL 1642

Query: 2209 LEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPE 2266
            L AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GG+IDPV   RVP +
Sbjct: 1643 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVPVD 1702

Query: 2267 IALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGER 2326
            +A + G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+  +L    ++
Sbjct: 1703 VAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQIIKK 1762

Query: 2327 NISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY--QWKEAMFFES 2384
              + + + +  R  V+ ++T         F   ++    + +L    Y  + ++    + 
Sbjct: 1763 GENYVYINEATR-HVLQSRTAKMRV--GRFADQVVS---FWDLLSSPYFTEDRKRELIQE 1816

Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGT-IDKALVKKYQEGLITLTELADSLLSRLVPKKD 2443
            YG  S  L      +   I E   Q   I  A ++    G +T    AD   SR++ +K 
Sbjct: 1817 YGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIR----GEVT---AADLFNSRVIDQKT 1869

Query: 2444 LHS-------------------------PVAGYWLTASGERISVLKASRRNLVDRITALR 2478
            LH+                          +AG  + ++ E +S+ +ASR+ L+    A  
Sbjct: 1870 LHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATW 1929

Query: 2479 CLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSV 2538
             LEAQ +TG ++DP T +K  V EA+  GLV+E   ++L + E   TG   P T   + +
Sbjct: 1930 LLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTIPL 1989

Query: 2539 VEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKS 2598
             +A+   +I K   +R LE Q  TGG+I+PQ H RL +E A + G +   I   + DQK 
Sbjct: 1990 FQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKH 2049

Query: 2599 YVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
              +  + P T+ K++Y+E  E+      TG  L  V++
Sbjct: 2050 MRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNK 2087



 Score =  255 bits (651), Expect = 5e-67
 Identities = 187/570 (32%), Positives = 303/570 (53%), Gaps = 34/570 (5%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
            F GLR TVT  +L++A+++D    E+L  G  T ++V    +  ++L     IAGL L  
Sbjct: 560  FSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPG 619

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
            ++E++S   A  + ++    AL  LEAQAATGFIIDP + + +SVE+A+   V+ P+   
Sbjct: 620  SQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFA 679

Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GGVIDPV   RVP
Sbjct: 680  KLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 739

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
             ++A ++G  +  +   L +PS +T+ F +PN  + L Y +LL  CV D E+  +L P  
Sbjct: 740  VDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLS 799

Query: 2325 ERN--ISNLNVKKTHRISVVDTKTGS---------ELTVYEAF----QRNLIEKSIYLEL 2369
                 + +   ++  +  ++  K G          EL   E F    +R L+ +    E+
Sbjct: 800  STQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREV 859

Query: 2370 S-GQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLT 2428
            + GQ  +  EA   E+   +  ML   ++ +   +++ +E G ID+ L+ +   G I+  
Sbjct: 860  TLGQVAKLLEA---ETQRQADIMLPALRSRV--TVHQLLEAGIIDQQLLDQVLAGTIS-- 912

Query: 2429 ELADSLLSRLVPKKDLHS--PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVST 2486
               ++LL     ++ L     V G  L  SG+R+S+ +A R+ L+    AL  LEAQ +T
Sbjct: 913  --PEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAAT 970

Query: 2487 GGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANI 2546
            G I+DP + +   V EA+ RG+V      +L++ E  I G   P + K +SV +A+   +
Sbjct: 971  GTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGL 1030

Query: 2547 INKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICP 2606
            I  E   R LE Q  TGG+I+P  H  L +  A+Q G +D  + T L    S       P
Sbjct: 1031 IPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETAL---SSSSETFPTP 1087

Query: 2607 QTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
              + + +Y + LE+   D  +GL LL + E
Sbjct: 1088 DGQGRTSYAQLLEECPRDETSGLHLLPLPE 1117



 Score =  224 bits (571), Expect = 9e-58
 Identities = 167/564 (29%), Positives = 277/564 (49%), Gaps = 22/564 (3%)

Query: 2091 GLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEV--QKTLNKFLTKATSIAGLYLESTK 2148
            G R  V A  L++A ++   T+E L  G ++  +V  Q  +   L     +AG+ L+ + 
Sbjct: 1198 GPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSG 1257

Query: 2149 EKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208
             K S A A    ++   +    LEAQ A+GF++DP++ Q  SVEDAV  G+V  E   +L
Sbjct: 1258 AKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQL 1317

Query: 2209 LEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPE 2266
             +AE+AA GY   YS  +LS++QAME  ++ + +G  +L+ Q+A+GGV+DPV G+ +P  
Sbjct: 1318 GQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQA 1377

Query: 2267 IALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGER 2326
             A + GLL+    Q L     + + F +P+ +  + Y +L   CV D E+   L P    
Sbjct: 1378 AACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSD 1437

Query: 2327 NISNL--NVKKTHRISVVDTKTGS---------ELTVYEAFQRNLIEKSIYLELSGQQYQ 2375
             +  +  +     R   V   TG          +L + E    +   + + L  SG+   
Sbjct: 1438 TVLEVDDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAA 1497

Query: 2376 WKE---AMFFESYGHSSHMLTDTKTGLHFNIN--EAIEQGTIDKALVKKYQEGLITLTEL 2430
             ++   A+           L  T  GL   ++  +      I +  + +  +G  T+ E+
Sbjct: 1498 LRQVVSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEV 1557

Query: 2431 ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGII 2490
            A+  +  +    +  + +AG  +  + ER+S+ +A RR+++   TAL  LEAQ +TG II
Sbjct: 1558 AE--MDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFII 1615

Query: 2491 DPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKE 2550
            DP   +K  V EA   G+  +    +L   E  +TG   P T + +S+ +A+  ++I +E
Sbjct: 1616 DPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVRE 1675

Query: 2551 MGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKR 2610
             GIR LE Q  TGG+I+P    R+ ++ A + G  D  +   L D     +    P T  
Sbjct: 1676 HGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHE 1735

Query: 2611 KLTYKEALEKADFDFHTGLKLLEV 2634
             LTY + LE+   D  TGL LL++
Sbjct: 1736 NLTYLQLLERCVEDPETGLYLLQI 1759



 Score =  223 bits (567), Expect = 3e-57
 Identities = 172/596 (28%), Positives = 281/596 (47%), Gaps = 71/596 (11%)

Query: 2088 KFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLN---KFLTKATSIAGLYL 2144
            K   +R  VTA  L  ++++D +T+  LR+G +T  +   TL     +L  +  IAG+ +
Sbjct: 1846 KVAAIRGEVTAADLFNSRVIDQKTLHTLRVG-RTGGQALSTLECVKPYLEGSDCIAGVTV 1904

Query: 2145 ESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEF 2204
             ST+E +S   A+ + +I    A   LEAQAATGF++DP + Q  SV++AV  G+V+ E 
Sbjct: 1905 PSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEEL 1964

Query: 2205 RIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIR 2262
            R RLL+AE+AA GY    +  T+ +FQAM+ +++++ +   +LE Q+A+GGVIDP    R
Sbjct: 1965 RERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHR 2024

Query: 2263 VPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFP 2322
            +P E A ++G L+  I   + +     + F +PN ++ + Y EL   C    ++   LFP
Sbjct: 2025 LPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFP 2084

Query: 2323 FGERNISNLNV---------------------------------------KKTHRISVVD 2343
              +    + ++                                       KK   + +  
Sbjct: 2085 VNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYR 2144

Query: 2344 TKTGSELTVYEAFQRNLIEK----SIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGL 2399
            T T   L         LIEK    + +L   G + Q   +    S   +  ML D +TG 
Sbjct: 2145 THTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETG- 2203

Query: 2400 HFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGER 2459
                  +  Q  ++   VK+Y EG          +   LVP KD              E+
Sbjct: 2204 -----RSTTQELMEDDRVKRYLEG-------TSCIAGVLVPAKD---------QPGRQEK 2242

Query: 2460 ISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQ 2519
            +S+ +A  + ++   TAL  LEAQ +TG +IDP+   +  V E +  G+V     ++L  
Sbjct: 2243 MSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLS 2302

Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579
             E  +TG   P T + +S+ +A+  ++I +E GIR LE Q  TGG+I+P    R+ ++ A
Sbjct: 2303 AERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVA 2362

Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635
             + G  D  +   L D     +    P T   LTY + L +   D  TGL +L+++
Sbjct: 2363 YRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 2418



 Score =  216 bits (549), Expect = 3e-55
 Identities = 177/575 (30%), Positives = 276/575 (48%), Gaps = 38/575 (6%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEV--QKTLNKFLTKATSIAGLYLES 2146
            F+ +   V+A +L+E  +LD + ++ LR G     +V  +  + ++L    S+AG+ L  
Sbjct: 235  FRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLP 294

Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
               K SF  AA   ++    AL  LEAQAAT  ++DPI+GQ   V++AV  G+V PE   
Sbjct: 295  EGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHE 354

Query: 2207 RLLEAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
            +LL AE+A  G+   +S   + +FQAM+  ++DR     +L+AQ+A+GG++ P R +R+P
Sbjct: 355  QLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLP 414

Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPF- 2323
             E AL+ G L+    + L +  S      +      L Y +LL +CV D E+     P  
Sbjct: 415  LEAALRCGCLDEDTQRQLSQAGSF-----SDGTHGGLRYEQLLALCVTDPETGLAFLPLS 469

Query: 2324 -----GERNISNLNVKKTHRISVVDTKT-------GSELTVYEAFQRNLIEKSIYLELSG 2371
                 GE          T +     T T       G  ++++E      I  S    +  
Sbjct: 470  GGPRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAI-SSEQRAMLA 528

Query: 2372 QQYQWKEAMFFESYGHSSHMLTD-------TKTGLHFNI--NEAIEQGTIDKALVKKYQE 2422
            QQYQ       +     S  L         T +GL   +   E ++   ID+ L ++ + 
Sbjct: 529  QQYQEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEH 588

Query: 2423 GLITLTELADSLLSRLVPKKDLHSP--VAGYWLTASGERISVLKASRRNLVDRITALRCL 2480
            G  T  ++  SL S    ++ L     +AG  L  S ER+S+ +A  + L+   TAL  L
Sbjct: 589  GQATAKDVG-SLAS---AQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILL 644

Query: 2481 EAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVE 2540
            EAQ +TG IIDP   K + V EAL   ++      +L   E  +TG   P T + +S+ +
Sbjct: 645  EAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQ 704

Query: 2541 AVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYV 2600
            A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D ++   L D     
Sbjct: 705  AMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDT 764

Query: 2601 RNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635
            +    P T   LTY + LE+   D  TGL LL +S
Sbjct: 765  KGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLS 799



 Score =  174 bits (440), Expect = 1e-42
 Identities = 154/609 (25%), Positives = 268/609 (44%), Gaps = 109/609 (17%)

Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEV--QKTLNKFLTKATSIA 2140
            R  +     LR  VT  QL+EA ++D + ++Q+  G  + E +     + ++L    ++ 
Sbjct: 874  RQADIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVG 933

Query: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200
            G+ L  + +++S   A  + ++   VALA LEAQAATG I+DP S ++ SV++AV +GVV
Sbjct: 934  GVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVV 993

Query: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258
             PE   RL  AE A  G+   +S K +SVFQAM+  ++  ++   +LEAQ+A+GG+IDP 
Sbjct: 994  GPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPT 1053

Query: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318
                +P  +A+Q+G ++  +   L   SS++  FP P+ +    Y++LL  C  D  S  
Sbjct: 1054 SHHHLPMPVAIQRGYVDQEMETAL---SSSSETFPTPDGQGRTSYAQLLEECPRDETSGL 1110

Query: 2319 FLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKE 2378
             L P  E                    +   L   E  QR+L                 +
Sbjct: 1111 HLLPLPE--------------------SAPALPTEEQVQRSL-----------------Q 1133

Query: 2379 AMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLL--- 2435
            A+     G S   L D  +  HF   +        + L++  QEG  T+ +L  S+    
Sbjct: 1134 AVPGAKDGTS---LWDLLSSCHFTEEQR-------RGLLEDVQEGRTTVPQLLASVQRWV 1183

Query: 2436 --SRLVPKKDLHSP-----VAGYWLTASG-------ERISVLKASRRNLVDRITALRCLE 2481
              ++L+ +  +  P     V   WL  +G       E ++    S   + ++     CL 
Sbjct: 1184 QETKLLAQARVMVPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLW 1243

Query: 2482 AQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEA 2541
                  G++   +G K  +A+A+  GL+  G  Q+L + ++    +  P+ N+ +SV +A
Sbjct: 1244 GTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDA 1303

Query: 2542 VNANIINKEM--------------------------------------GIRCLEFQYLTG 2563
            V   ++ +E+                                      G+  L+ Q  TG
Sbjct: 1304 VKVGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATG 1363

Query: 2564 GLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADF 2623
            G+++P     L    A ++G++D   +  L       +    P  + ++TY++  E+   
Sbjct: 1364 GVVDPVHGVHLPQAAACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVC 1423

Query: 2624 DFHTGLKLL 2632
            D  TGL LL
Sbjct: 1424 DSETGLLLL 1432



 Score =  166 bits (419), Expect = 4e-40
 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%)

Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140
            R  +  F+GLR  V+A +L  + +L   T+  L  G KT++EV +  ++ ++L   + IA
Sbjct: 2702 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 2761

Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195
            G+ + +      +EK+S   A  + ++    AL  LEAQAATGF+IDP+     SVE+AV
Sbjct: 2762 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 2821

Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253
              GVV  E + +LL AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GG
Sbjct: 2822 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 2881

Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313
            VIDPV   RVP ++A ++G  +  + + L +PS +T+ F +PN  + L Y +LLR CV D
Sbjct: 2882 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 2941

Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373
             ++  ++     R  +   + +  R ++ D +        +    ++ E   Y E+S  +
Sbjct: 2942 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 3001

Query: 2374 YQ 2375
             Q
Sbjct: 3002 RQ 3003



 Score =  166 bits (419), Expect = 4e-40
 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%)

Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140
            R  +  F+GLR  V+A +L  + +L   T+  L  G KT++EV +  ++ ++L   + IA
Sbjct: 3236 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 3295

Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195
            G+ + +      +EK+S   A  + ++    AL  LEAQAATGF+IDP+     SVE+AV
Sbjct: 3296 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 3355

Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253
              GVV  E + +LL AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GG
Sbjct: 3356 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 3415

Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313
            VIDPV   RVP ++A ++G  +  + + L +PS +T+ F +PN  + L Y +LLR CV D
Sbjct: 3416 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 3475

Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373
             ++  ++     R  +   + +  R ++ D +        +    ++ E   Y E+S  +
Sbjct: 3476 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 3535

Query: 2374 YQ 2375
             Q
Sbjct: 3536 RQ 3537



 Score =  166 bits (419), Expect = 4e-40
 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%)

Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140
            R  +  F+GLR  V+A +L  + +L   T+  L  G KT++EV +  ++ ++L   + IA
Sbjct: 3770 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 3829

Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195
            G+ + +      +EK+S   A  + ++    AL  LEAQAATGF+IDP+     SVE+AV
Sbjct: 3830 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 3889

Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253
              GVV  E + +LL AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GG
Sbjct: 3890 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 3949

Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313
            VIDPV   RVP ++A ++G  +  + + L +PS +T+ F +PN  + L Y +LLR CV D
Sbjct: 3950 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 4009

Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373
             ++  ++     R  +   + +  R ++ D +        +    ++ E   Y E+S  +
Sbjct: 4010 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 4069

Query: 2374 YQ 2375
             Q
Sbjct: 4070 RQ 4071



 Score =  166 bits (419), Expect = 4e-40
 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%)

Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140
            R  +  F+GLR  V+A +L  + +L   T+  L  G KT++EV +  ++ ++L   + IA
Sbjct: 4304 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 4363

Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195
            G+ + +      +EK+S   A  + ++    AL  LEAQAATGF+IDP+     SVE+AV
Sbjct: 4364 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 4423

Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253
              GVV  E + +LL AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GG
Sbjct: 4424 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 4483

Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313
            VIDPV   RVP ++A ++G  +  + + L +PS +T+ F +PN  + L Y +LLR CV D
Sbjct: 4484 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 4543

Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373
             ++  ++     R  +   + +  R ++ D +        +    ++ E   Y E+S  +
Sbjct: 4544 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 4603

Query: 2374 YQ 2375
             Q
Sbjct: 4604 RQ 4605



 Score =  161 bits (408), Expect = 7e-39
 Identities = 97/296 (32%), Positives = 166/296 (56%), Gaps = 9/296 (3%)

Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKT--LNKFLTKATSIAGLYLES 2146
            FQG+R  +TA +L+ + ++    ++ L  G  T +E+ +   + ++L   + IAG+ + +
Sbjct: 2174 FQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPA 2233

Query: 2147 T-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVD 2201
                  +EK+S   A  + ++    AL  LEAQAATGF+IDP+     SVE+ V  GVV 
Sbjct: 2234 KDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVG 2293

Query: 2202 PEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVR 2259
             E + +LL AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GGVIDPV 
Sbjct: 2294 SEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVH 2353

Query: 2260 GIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCF 2319
              RVP ++A ++G  +  + + L +PS +T+ F +PN  + L Y +LLR CV D ++  +
Sbjct: 2354 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLY 2413

Query: 2320 LFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQ 2375
            +     R  +   + +  R ++ D +        +    ++ E   Y E+S  + Q
Sbjct: 2414 MLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQ 2469



 Score =  158 bits (400), Expect = 6e-38
 Identities = 93/243 (38%), Positives = 148/243 (60%), Gaps = 9/243 (3%)

Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140
            R  +  F+GLR  V+A +L  + +L   T+  L  G KT++EV +  ++ ++L   + IA
Sbjct: 4838 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 4897

Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195
            G+ + +      +EK+S   A  + ++    AL  LEAQAATGF+IDP+     SVE+AV
Sbjct: 4898 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 4957

Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253
              GVV  E + +LL AE+A  GY+  Y+ + +S+FQAM+  ++ R+ G  +LEAQIA+GG
Sbjct: 4958 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 5017

Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313
            VIDPV   RVP ++A ++G  +  + + L +PS +T+ F +PN  + L Y +LL+    D
Sbjct: 5018 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLD 5077

Query: 2314 VES 2316
             E+
Sbjct: 5078 PET 5080



 Score =  155 bits (391), Expect = 7e-37
 Identities = 124/417 (29%), Positives = 195/417 (46%), Gaps = 53/417 (12%)

Query: 2135 KATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDA 2194
            +A SIAG+Y+E++ +  S  +A E+ ++   +  A LEAQAATG ++D   GQ   V  A
Sbjct: 39   QARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKA 98

Query: 2195 VLKGVVDPEFRIRLLEAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASG 2252
            + +G+V  E + +LL AE+A  GY   Y  + L++FQA+   ++DR  G+  LE Q+A+G
Sbjct: 99   LQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATG 158

Query: 2253 GVIDPVRGIRVPPEIALQQGLLNNAILQFLH--EPSSNTRVFPNPNNKQALYYSELLRMC 2310
            G++DP +G+ V PE A  QGLL+      L   EP +    F NPN  + L Y +LL  C
Sbjct: 159  GLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERC 218

Query: 2311 VFDVESQCFLFPF-------------------GERNISNLNVKKTHRISVVDTKTGSELT 2351
            V    S   L P                    G  +   +   +  R++ VD    +E+ 
Sbjct: 219  VRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVR 278

Query: 2352 VYEAFQRNLI---------EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFN 2402
             Y     ++          +KS +   +        A+       ++H L D  TG    
Sbjct: 279  RYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLW 338

Query: 2403 INEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISV 2462
            ++EA+  G +                EL + LL            V G+    SG +I +
Sbjct: 339  VDEAVRAGLVS--------------PELHEQLLV-------AEQAVTGHHDPFSGSQIPL 377

Query: 2463 LKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQ 2519
             +A ++ LVDR  ALR L+AQ++TGG++ P    +  +  AL  G +DE   +QL Q
Sbjct: 378  FQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQ 434



 Score =  104 bits (259), Expect = 1e-21
 Identities = 70/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%)

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
            VK+Y EG   +  +       LVP KD              E++S+ +A  + ++   TA
Sbjct: 4886 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 4929

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            L  LEAQ +TG +IDP+   +  V EA+  G+V     ++L   E  +TG   P T + +
Sbjct: 4930 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 4989

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596
            S+ +A+  ++I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D  +   L D 
Sbjct: 4990 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 5049

Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635
                +    P T   LTY + L++A  D  TGL  L +S
Sbjct: 5050 SDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLS 5088



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%)

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
            VK+Y EG   +  +       LVP KD              E++S+ +A  + ++   TA
Sbjct: 2750 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 2793

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            L  LEAQ +TG +IDP+   +  V EA+  G+V     ++L   E  +TG   P T + +
Sbjct: 2794 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 2853

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596
            S+ +A+  ++I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D  +   L D 
Sbjct: 2854 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 2913

Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635
                +    P T   LTY + L +   D  TGL +L+++
Sbjct: 2914 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 2952



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%)

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
            VK+Y EG   +  +       LVP KD              E++S+ +A  + ++   TA
Sbjct: 3284 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 3327

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            L  LEAQ +TG +IDP+   +  V EA+  G+V     ++L   E  +TG   P T + +
Sbjct: 3328 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 3387

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596
            S+ +A+  ++I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D  +   L D 
Sbjct: 3388 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 3447

Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635
                +    P T   LTY + L +   D  TGL +L+++
Sbjct: 3448 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 3486



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%)

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
            VK+Y EG   +  +       LVP KD              E++S+ +A  + ++   TA
Sbjct: 3818 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 3861

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            L  LEAQ +TG +IDP+   +  V EA+  G+V     ++L   E  +TG   P T + +
Sbjct: 3862 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 3921

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596
            S+ +A+  ++I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D  +   L D 
Sbjct: 3922 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 3981

Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635
                +    P T   LTY + L +   D  TGL +L+++
Sbjct: 3982 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 4020



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%)

Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476
            VK+Y EG   +  +       LVP KD              E++S+ +A  + ++   TA
Sbjct: 4352 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 4395

Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536
            L  LEAQ +TG +IDP+   +  V EA+  G+V     ++L   E  +TG   P T + +
Sbjct: 4396 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 4455

Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596
            S+ +A+  ++I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D  +   L D 
Sbjct: 4456 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 4515

Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635
                +    P T   LTY + L +   D  TGL +L+++
Sbjct: 4516 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 4554



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 57/195 (29%), Positives = 99/195 (50%), Gaps = 2/195 (1%)

Query: 2440 PKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYR 2499
            P +     +AG ++ ASG+  SV  A  + L+        LEAQ +TGG++D   G+   
Sbjct: 35   PPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLP 94

Query: 2500 VAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQ 2559
            V++AL +GLV     ++L   E   TG   P   + +++ +A+   ++++ +G   LE Q
Sbjct: 95   VSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQ 154

Query: 2560 YLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNI--ICPQTKRKLTYKEA 2617
              TGGL++P     ++ E A   G++D     KL + +    ++  + P T  +LTY + 
Sbjct: 155  LATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQL 214

Query: 2618 LEKADFDFHTGLKLL 2632
            LE+      +GL LL
Sbjct: 215  LERCVRAPGSGLALL 229



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 75/334 (22%), Positives = 129/334 (38%), Gaps = 48/334 (14%)

Query: 2341 VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH 2400
            +VD   G  L V +A Q+ L+     LEL       KE +       + +   D   G  
Sbjct: 84   LVDLARGQLLPVSKALQQGLVG----LEL-------KEKLLAAERATTGY--PDPYGGEK 130

Query: 2401 FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLV-PKKDLHSPVAG----YWLTA 2455
              + +AI +  +D+AL + + E  +    L D     LV P+   H  +      + L+ 
Sbjct: 131  LALFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSE 190

Query: 2456 SGERISVLKASRRNLVDRITALRCLEAQVSTGG---IIDPLT------GKKYRVAEALHR 2506
                   L+    N ++R+T  + LE  V   G    + PL       G     AE L  
Sbjct: 191  LEPGTGDLRFLNPNTLERLTYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEV 250

Query: 2507 GLVDEGFAQQLRQCELV-------------------ITGIGHPITNKMMSVVEAVNANII 2547
            G++DE   Q LR+  L                    + G+         S  +A   +++
Sbjct: 251  GILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLL 310

Query: 2548 NKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQ 2607
                 +  LE Q  T  L++P    RL ++EA++ G++   +  +L   +  V     P 
Sbjct: 311  PMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPF 370

Query: 2608 TKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTG 2641
            +  ++   +A++K   D    L+LL+    L TG
Sbjct: 371  SGSQIPLFQAMKKGLVDRPLALRLLDAQ--LATG 402



 Score = 39.7 bits (91), Expect = 0.040
 Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 2/118 (1%)

Query: 2524 ITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVG 2583
            I G+    + +  SV  A+   ++   +G   LE Q  TGGL++      L + +ALQ G
Sbjct: 43   IAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQQG 102

Query: 2584 IIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTG 2641
            ++ + +  KL   +        P    KL   +A+ K   D   G   LEV   L TG
Sbjct: 103  LVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQ--LATG 158


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  179 bits (453), Expect = 4e-44
 Identities = 357/1788 (19%), Positives = 747/1788 (41%), Gaps = 230/1788 (12%)

Query: 248  NSLQTLKLMQIRKPLLKSSLLDQ---NLTEEE----INMKFVQDLLNWVDEMQVQLDRTE 300
            N+L++LK  Q     LKS + ++   NL  EE       +F Q ++    +  ++   T+
Sbjct: 968  NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027

Query: 301  WGSDLPSVESHLENHKNVHRAIEE-------FESSLKEAKISEIQMTAPLKLTYA--EKL 351
              +        +E  + +   I+E        ES + E +  +  +   +++T    E+L
Sbjct: 1028 TLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087

Query: 352  HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARK 411
              L  +  K       ++ H       +SR  + L  + EK +E        ++  +  K
Sbjct: 1088 RLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE--------KSQQLQEK 1139

Query: 412  KDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCV 471
            +     +  E+ + ++ I  ++ +  +L  +     LT+E     M+T+    L+L Q +
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKE----LTLEH----METER---LELAQKL 1188

Query: 472  EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
             ++ +E           K  T   + LK+ +Q+ +  +R      + ++    ++ KEEL
Sbjct: 1189 NENYEE----------VKSITKERKVLKE-LQKSFETERDHLRGYIREIEATGLQTKEEL 1237

Query: 532  LQYKSTIANLMGKAKTIIQLKPRNSD--CPLKTSIPIKAICDYRQIEITIYKDDECVLAN 589
               K    +L    +TI +L+   S+    +  +  ++      Q EI +  +++ +L N
Sbjct: 1238 ---KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294

Query: 590  NSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKS 649
                   K +S T  E M      T     K++  LA RIE +   +   + ES   +KS
Sbjct: 1295 V------KEVSET-QETMNELELLTEQSTTKDSTTLA-RIEMERLRLNEKFQESQEEIKS 1346

Query: 650  VVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDIT 709
            +                N+ +IK  L  +H Q    L+    + L   QESQ      + 
Sbjct: 1347 LTK-----------ERDNLKTIKEALEVKHDQ----LKEHIRETLAKIQESQSKQEQSLN 1391

Query: 710  QLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE 769
              EK+    K     ++   E+ + ++S       E+  +  RL+   D +    +   E
Sbjct: 1392 MKEKDNETTK-----IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK---E 1443

Query: 770  RDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQA-AASSSVPTLRSELNVVL 828
            +DDL         QE L+ E ++LK+++  I  K  E   +   A   +      +N + 
Sbjct: 1444 KDDLQRL------QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497

Query: 829  QNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST 888
             N+++  +  ST   +L+ +N  L+N      + ++YE    EE+  I   + ++  ++ 
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKLQNK-----IQEIYEK---EEQFNIKQISEVQEKVNE 1549

Query: 889  LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948
            LKQ++     K     ++E ++ +   +++ + ++ +E  +     KE+  ++ E  Q  
Sbjct: 1550 LKQFKEHRKAKDSALQSIESKMLE---LTNRLQESQEEIQIMIK-EKEEMKRVQEALQIE 1605

Query: 949  HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008
              Q+    +++  + K  +     Y  L   +  V  TQ K+ E +      L  Q   Q
Sbjct: 1606 RDQLKENTKEI--VAKMKESQEKEYQFLK--MTAVNETQEKMCEIEH-----LKEQFETQ 1656

Query: 1009 KMLVSEIEMKQSKMDEC--QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR----RR 1062
            K+ +  IE +  ++ +   +   E  S T +  +L+++     V+  Q     R    R 
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716

Query: 1063 MQSSADLII--------QEFMD----LRTRYTALVTLMTQYIKFAGDSLK----RLEEE- 1105
            ++   +L I        QE +D    + +  T  ++ M + ++ + D+LK    +++EE 
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776

Query: 1106 -----EIKRCKETSE--HGAYSD----LLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
                  +K  +ET +   G  S+    L   QK     N+KL  KI EL+    +L   K
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836

Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAES------------EAKQYRRELET 1202
              V E   KV E    +L+KQ ++ + ++L K+  E+            E K   +E + 
Sbjct: 1837 KDVNETQKKVSEM--EQLKKQIKD-QSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893

Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262
            + R +E  + E +++++   E +A+   +++ L   R   +E+  T   L + +  K + 
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953

Query: 1263 LNDLEQQKNKLMEELRRK-RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR 1321
            ++D+++  +K  +EL++K ++ +++ L+L++  E        ++ K++ E ++++ +   
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE-----DVNMSHKKINEMEQLKKQFEA 2008

Query: 1322 KITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVD-------ELTAA 1374
            +   +Q    +N      + ++     +   +++  ++  E LK + D       E+ A 
Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR 2068

Query: 1375 NRKAEQDMRELTYELNALQLEKTSSEEKARLLKD------KLDETNNTLRCLKLELERKD 1428
            +R+  Q   E     +  Q    S  EK   +K+      ++D+    L  L L+LE++ 
Sbjct: 2069 DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128

Query: 1429 QAEKGYSQQLR-ELGRQLNQT-------TGKAEEAMQEASDLKKIKR--NYQLELESLNH 1478
            + +K  S +++  L     QT       T     +M+    +KK+K   +Y  +++   H
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQH 2188

Query: 1479 EK-GKLQRE-VDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEK 1536
            E   K + + +D + +   +  K IQHL          +EL  L++ Q    H++E  + 
Sbjct: 2189 ESINKFEMDFIDEVEKQKELLIK-IQHLQQDCDV--PSRELRDLKLNQNMDLHIEEILKD 2245

Query: 1537 SHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAE 1596
              E    +IK E +     Q L+   E        + Q +EE      + + +   IQ E
Sbjct: 2246 FSESEFPSIKTEFQ-----QVLSNRKE--------MTQFLEEWLNTRFDIEKLKNGIQKE 2292

Query: 1597 SENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKI----KCLEED 1652
            ++ I         R  A+  ++  F+++  + ++   +  K+ ++   K+    + L+  
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTS 2352

Query: 1653 LAKSQ--NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQ 1710
            LA     N  ++  +     +   Q T +++R L   L+ +KE     E K+   Q +++
Sbjct: 2353 LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412

Query: 1711 ELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEE----SGKFKQSAEEFRKKMEKL----M 1762
              N+ + K+Q ++H      + T   + + Q++    +  +K+  E+ + K+ K+    M
Sbjct: 2413 VTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM 2472

Query: 1763 ESKVITENDISGIRL------DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816
            ++    E +IS  +       + + L +EN R  + A+  +T++       Q   + +  
Sbjct: 2473 KNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQ--DTSVISEHTDPQPSNKPLTC 2530

Query: 1817 GQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDC 1876
            G         K   L+ E I  ++E+  LKQ+ +Q IK+    L   Q    +  T K+ 
Sbjct: 2531 GGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKER 2590

Query: 1877 TFKPDF--EMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLE 1922
            T K +   ++T +    S +++   +     TP     R  Q+P P E
Sbjct: 2591 TLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKE 2638



 Score =  169 bits (428), Expect = 3e-41
 Identities = 301/1555 (19%), Positives = 622/1555 (40%), Gaps = 183/1555 (11%)

Query: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSA-----EREEQEESVYNLYISE-VRN 748
            +D +   +   S++  L K   V  Q  +  L S      E+E+Q + +     S+ + N
Sbjct: 546  KDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLEN 605

Query: 749  IRL----RLENCED-RLIRQIRTPLER---DDLHESVFRITEQEKLKKELERLKDDLGTI 800
            I++     LE+ ED + ++Q     E    D   ES F  +E  +LK++++ L      +
Sbjct: 606  IKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQM 665

Query: 801  TNKCEEFFSQAAASSSVPT-LRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVL--KNTQA 857
             N  + + SQ  A   +   L  EL      + ++ S+    + K    NL L  K T  
Sbjct: 666  ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725

Query: 858  AEALVK-LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI 916
             + L K + E +   EE ++  +  +++L S +++ R E+ +K +  H +  E  K K  
Sbjct: 726  QKELNKEVEENEALREEVILLSE--LKSLPSEVERLRKEIQDKSEELHIITSE--KDKLF 781

Query: 917  SDEMFKTYKERDLDFDWHKEK------------ADQLVERWQNVHVQIDNR----LRDLE 960
            S+ + K  + + L  +  K K             DQ  + ++ +H+  + +    L + E
Sbjct: 782  SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 841

Query: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
             + + +          D  +  ++T      +   E ++ +  +LN+ + L  ++E + S
Sbjct: 842  RMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 901

Query: 1021 KMDECQK----YAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076
             +   ++      E+   T+++ +  T     +   Q+   ++R +++S     +   +D
Sbjct: 902  TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961

Query: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKL 1136
             + +    +  + Q+ +       ++ EE  +        G   D  Q++   + +   L
Sbjct: 962  TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021

Query: 1137 TGK-------------ISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDIS 1183
              K             I E +R +  L ++K+ +++ L  V    E      + N+E   
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081

Query: 1184 LQKIRAESEAKQYRRELETIVREKEAA---ERELERVRQLTIEAEAKRAAVEENLLNFRN 1240
              +        + +++ E + +EK  A   E EL R          + A VEE L     
Sbjct: 1082 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD-------RLAEVEEKLKEKSQ 1134

Query: 1241 QLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAF 1300
            QL+E       +++ +      +N++E  KN+L  +       E E L+L +++ ++   
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194

Query: 1301 QKQVAE--KQLKEKQK-IELEA---RRKITEIQYTCRENALPVCPITQATSCRAVTGLQQ 1354
             K + +  K LKE QK  E E    R  I EI+ T            Q      +  +  
Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYIREIEATG----------LQTKEELKIAHIHL 1244

Query: 1355 EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD--KLDE 1412
            +  ++  +EL++ V E TA     +    +L      LQ E     E+  LL +  ++ E
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQ----DLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300

Query: 1413 TNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLE 1472
            T  T+  L+L  E+    +     ++     +LN+   K +E+ +E   L K + N +  
Sbjct: 1301 TQETMNELELLTEQSTTKDSTTLARIEMERLRLNE---KFQESQEEIKSLTKERDNLKTI 1357

Query: 1473 LESLNHEKGKLQREV-DRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHL- 1530
             E+L  +  +L+  + + + +      K  Q LN +       K +  ++  + K   L 
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417

Query: 1531 ---------KEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTR 1581
                      ++ ++SH+++    K+  +  D +QRL E L+  ++    LK+ ++E+  
Sbjct: 1418 RIEIEMLGLSKRLQESHDEM----KSVAKEKDDLQRLQEVLQSESD---QLKENIKEIVA 1470

Query: 1582 QNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQD 1641
            ++ ET+                        E LK+     K+Q  + NE     ++ E +
Sbjct: 1471 KHLETE------------------------EELKVAHCCLKEQEETINELRVNLSEKETE 1506

Query: 1642 FQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQK 1701
                 K LE    K QN + E  +K +Q NI       EV+    EL   KE ++  +  
Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEEQFNI---KQISEVQEKVNELKQFKEHRKAKDSA 1563

Query: 1702 VQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL 1761
            +Q  ++++ EL NRL++ Q+E+ +   E++   R     Q E  + K++ +E   KM++ 
Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623

Query: 1762 MES-----KVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816
             E      K+   N+      +   L+++    + N +  ET    L + L +  E+M+ 
Sbjct: 1624 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1683

Query: 1817 -----------GQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQC 1865
                        + ++    Q  + L + +     + E LK  +   +KEH+  +  L+ 
Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELK-IVHMHLKEHQETIDKLRG 1742

Query: 1866 EIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKW 1925
             + +K+         +     K+ +HS +        +    R   +   +E Q   +K 
Sbjct: 1743 IVSEKTN--------EISNMQKDLEHSNDALKAQDLKIQEELRIAHMH-LKEQQETIDKL 1793

Query: 1926 QHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIE-- 1983
            +  V E+  K    Q         K Q+   E  +     + +  D      ++SE+E  
Sbjct: 1794 RGIVSEKTDKLSNMQ-KDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1852

Query: 1984 --KIRDQALNNSRPPVRYQDNACEM-----ELVKVLTPLEIAKNKQYDMHTEVTTLKQEK 2036
              +I+DQ+L  S+  +   + A ++     E+  V+   +  +  +  +  E   LK+  
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912

Query: 2037 NPVPSAEEWMLEGCRASGGLKKG-----DFLKKGLEPETFQNFDGDHACSVRDDEFKFQG 2091
                + +  + +  + +  L K      D L++ +  +T Q  D         DE     
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE----- 1967

Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLES 2146
            L+  +   Q  E +LL  R  E + +  K + E+++   +F  +  S+  + +++
Sbjct: 1968 LQKKIQELQKKELQLL--RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDN 2020



 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 203/1053 (19%), Positives = 410/1053 (38%), Gaps = 191/1053 (18%)

Query: 1251 TLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQ------- 1303
            T E  LKR    + DL++Q  ++  E R +   +++L +L++  EKDL  + Q       
Sbjct: 340  TDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE--EKDLLQKVQNEKIENL 397

Query: 1304 ----VAEKQLKEKQKIELEARRKIT----------------------------------- 1324
                V    L  +Q+++ + +R++T                                   
Sbjct: 398  TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457

Query: 1325 --EI-QYTCRENAL---PVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKA 1378
              EI +  C E+ +    +  +++     A   L QE+ + +   L+   D L     + 
Sbjct: 458  LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517

Query: 1379 EQDMRELTY---------ELNALQLEKTSSEEKARLLKD--------------KLDETNN 1415
              +  E+           E  AL+  KT  +++ +L+ +                D  N 
Sbjct: 518  RTEKEEMELKLKEKNDLDEFEALE-RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENE 576

Query: 1416 TLRCLKLELERKDQAEKGY----SQQLRELGRQLNQTTGKAEEAMQEAS---DLKKIKRN 1468
                ++L  E++DQ +K      SQ+L  +   L+ +    E+  Q      D + +  +
Sbjct: 577  LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636

Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD-EKELER-LQICQRK 1526
             + E   L  E  +L+ ++  +   +   E +IQ   SQ+ + +  + +LE+ LQ    +
Sbjct: 637  AKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696

Query: 1527 SDHLKEQFE-KSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAE---------MLKQKV 1576
               L    + K  + LL N++ E +  D  + LN+E+E++    E          L  +V
Sbjct: 697  ITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEV 756

Query: 1577 EELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQT 1636
            E L ++  +    +  I +E + +  E    + R + L  +    KD L +T  +     
Sbjct: 757  ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN---YK 813

Query: 1637 KTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKR 1696
             T+Q+FQ   K L  D  +   +V E  ++ +Q+   I N  KE +  ++ L A K E  
Sbjct: 814  STDQEFQ-NFKTLHMDFEQKYKMVLEENERMNQE---IVNLSKEAQKFDSSLGALKTELS 869

Query: 1697 RGEQKVQLQQAQVQELNNRLKKVQDELH-----LKTIEEQMT--HRKMVLFQEESGKFKQ 1749
               Q++Q +  +VQE  N +++++++L      L+T+E + T    K+    EE     Q
Sbjct: 870  YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929

Query: 1750 SAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQ 1809
              ++ ++  E L   +   ++DI       +  Q++   A E+ K  +  I  L+ ++  
Sbjct: 930  EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKIS- 988

Query: 1810 YREQMQQGQHMEANHYQKCQKLEDELI-------------------AQKREVENLKQKMD 1850
              E++ +  HME N  +   + + +++                    +  E+   ++K+ 
Sbjct: 989  --EEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIF 1046

Query: 1851 QQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVK----------ECQHSGELSSRNT 1900
              I+E      +L+  I +K   K    K + EMT++          E +   E+ ++  
Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLK-TDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105

Query: 1901 GHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFS 1960
             H        L R       +EEK +        K  Q Q        EK QQ  +    
Sbjct: 1106 NHA-IKKEGELSRTCDRLAEVEEKLKE-------KSQQLQ--------EKQQQLLN--VQ 1147

Query: 1961 QTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKN 2020
            +  +E+Q   +E   +    + +++  + +   R  +  + N    E+  +    ++ K 
Sbjct: 1148 EEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKE 1207

Query: 2021 KQYDMHTEVTTLKQ-----EKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFD 2075
             Q    TE   L+      E   + + EE  +         +  D L++ +  +T Q   
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ--- 1264

Query: 2076 GDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLN--KFL 2133
                 + +D E     L+  +            +   ++L   +K V E Q+T+N  + L
Sbjct: 1265 ---IINTQDLEKSHTKLQEEIPV----------LHEEQELLPNVKEVSETQETMNELELL 1311

Query: 2134 TK------ATSIAGLYLESTKEKISFASAAERI 2160
            T+      +T++A + +E  +    F  + E I
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEI 1344


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  171 bits (432), Expect = 1e-41
 Identities = 264/1306 (20%), Positives = 547/1306 (41%), Gaps = 163/1306 (12%)

Query: 726  LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
            L+S E++ +E    N  I +++++    E    +L  +I     + D   S+    EQ K
Sbjct: 137  LQSLEQQLEEAQTENFNIKQMKDL---FEQKAAQLATEIADIKSKYDEERSLREAAEQ-K 192

Query: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
            + +  E L  +   I +   E   Q      V  L+ EL  V   M+ +        +KL
Sbjct: 193  VTRLTEELNKEATVIQDLKTELL-QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251

Query: 846  KTVNLVLKNTQAA-EALVKLYETKLC---EEEAV-IADKNNIENLISTLKQWRSEVDE-- 898
            K     L++  A+ EA +    ++L    +E AV + +   +++ ++ L Q    + E  
Sbjct: 252  KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311

Query: 899  --KRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
              K Q +  LE++  +       +  T  ++DLD    + +          +HV++  + 
Sbjct: 312  LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG 371

Query: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN----QPE----NSKTLATQ---- 1004
               + + + L      Y  L    +Q++  + + +++    Q E    +SK L T+    
Sbjct: 372  EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431

Query: 1005 -----LNQQKMLVSEIEM-KQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
                 L +Q+ L SE  M K+ ++ + Q    +    +K+    +   +  +D  ++   
Sbjct: 432  EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ 491

Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118
            +++ +Q S    ++E  +           + Q ++  GD  ++++  E            
Sbjct: 492  EQQALQQSTTAKLREAQND----------LEQVLRQIGDKDQKIQNLEA----------- 530

Query: 1119 YSDLLQRQKATVL----ENSKLTGKISELERMVA---ELKKQKSRVEEELPKVREAAENE 1171
               LLQ+ K  +     E   L  KI   E   A   +L+++   ++E++ ++ E  +N+
Sbjct: 531  ---LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587

Query: 1172 L---RKQQRNVEDISLQKIRAESEAKQYR-RELETIVREKEAAEREL-ERVRQLTIEAEA 1226
                ++ Q N+ D  +Q+ +A   A Q R   LET V E  +   E  E+V QL I+ +A
Sbjct: 588  SESHKQAQENLHD-QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646

Query: 1227 K--------------RAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNK 1272
            K              RA ++ +L   +N L++       +   L +    L D ++  ++
Sbjct: 647  KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706

Query: 1273 LMEELRRKRDN-------EEELLKLIKQMEKD---LAFQKQVAEKQLKEKQKIELEARRK 1322
            L   L+  ++         EEL   IK++E D   +   K+ A + L++++++  +   +
Sbjct: 707  LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766

Query: 1323 ITEI--QYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEE--LKQQVDELTAANRKA 1378
             TE+  Q    +  +    +       A+  ++Q+  KQ+ E+  LKQ  + L+   +  
Sbjct: 767  ATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826

Query: 1379 EQDMRE----LTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGY 1434
             +++         EL  +++EK +   +   +KDKL + +++L+  K E E+++Q  K  
Sbjct: 827  HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886

Query: 1435 SQQLRELGRQL-NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRA 1493
               L +  ++L +Q   + E  ++E  +LKK     +     L  E   +Q ++ +    
Sbjct: 887  ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946

Query: 1494 HAVAEKNIQHLNSQIHSFRD-----EKELERLQ----ICQRKSDHLKEQFEKSHEQLLQN 1544
                EK  Q L   I+  +      +K++E LQ    I   +   L+ + ++   Q  Q 
Sbjct: 947  LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE 1006

Query: 1545 IKAEKENNDKIQRLNEELEKSNECAEMLKQ----KVEELTRQNNETKLMMQRIQAESENI 1600
            + AEKE   KI  L    EKS E  + L+     +  EL     + K + +++    E++
Sbjct: 1007 LAAEKE---KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063

Query: 1601 VLEKQTIQQR---CEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657
            +  +  I  +    + LK      +       + L ++ K  QD Q++    E++L   +
Sbjct: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123

Query: 1658 NLVSEFKQ-KCDQQNIIIQNTKKEVRNLNAELNASKEEK-------RRGEQKVQLQQAQV 1709
            + ++E ++ KC Q+        KE+  LN EL + K E        +  +Q +  Q+ ++
Sbjct: 1124 SKLAEIEEIKCRQE--------KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175

Query: 1710 QELNNRLKKV--QDELHLKTIEEQMTHRKMVL---FQEESGKFKQSAEEFRKKMEKLMES 1764
            Q   + LK    Q++ + + +++Q+   +  L   F E+  K     +E    M+K  E+
Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1235

Query: 1765 KVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANH 1824
            +      I+ +  +  ++++E   +Q      E    +L  ++      +Q  Q      
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295

Query: 1825 YQKCQKLEDELIAQKREVENLKQKMD------QQIKEHEHQLVLLQCEIQKKSTAKDCTF 1878
             ++C K E E+   + +V  L++K+D      Q++      L +   +   +  A+D   
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355

Query: 1879 K------PDFEMTVK--ECQHSG-----ELSSRNTGHLHPTPRSPL 1911
            +        F +TV+   C+  G     E S++N   L P+ + P+
Sbjct: 1356 QNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNA--LTPSSKKPV 1399



 Score =  142 bits (357), Expect = 6e-33
 Identities = 243/1171 (20%), Positives = 466/1171 (39%), Gaps = 168/1171 (14%)

Query: 1105 EEIKRCKETSEHGAYSDL-LQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPK 1163
            E +      S HG  S+L L+R   T+L          E++ + A LK++K   EE    
Sbjct: 61   EAVHDAGNDSGHGGESNLALKRDDVTLLRQ--------EVQDLQASLKEEKWYSEE---- 108

Query: 1164 VREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIE 1223
                    L+K+    + +  Q+ + +        EL+++ ++ E A+ E   ++Q+   
Sbjct: 109  --------LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160

Query: 1224 AEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDN 1283
             E K A +   + + +++ +E    R   E  + R    LN        L  EL  +R  
Sbjct: 161  FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL-LQRPG 219

Query: 1284 EEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQA 1343
             E++  L K++ +       +  ++ +E +K++ E ++   + QY   E  +       A
Sbjct: 220  IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK--LQSQYASSEATISQLRSELA 277

Query: 1344 TSCRAVTGLQQEHDKQKA--EELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS--- 1398
               + V    QE  K K+   EL Q+   LT    K EQD  +L  + N   + K +   
Sbjct: 278  KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337

Query: 1399 ----SEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEE 1454
                 +   + L+ +L  +  +L  + +EL  K +A +   ++L E+  +      + ++
Sbjct: 338  TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 397

Query: 1455 AMQEASDLKKIKRNYQLELESLNHEKGKLQREV---------DRITRAHAVAEKNIQHLN 1505
              Q+  + ++     Q E+  L+ +  + +R++          R   +  + +K  Q  +
Sbjct: 398  LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457

Query: 1506 SQIHSFRDEKELE---------RLQICQRKSDHLKEQ---------FEKSHEQLLQNIKA 1547
             Q+   R E++L+         + Q+ + K  H ++Q           ++   L Q ++ 
Sbjct: 458  LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517

Query: 1548 EKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQA-ESENIVLEKQT 1606
              + + KIQ L   L+KS E   +L+++ E+L            +IQA E E  VL +  
Sbjct: 518  IGDKDQKIQNLEALLQKSKENISLLEKEREDL----------YAKIQAGEGETAVLNQ-- 565

Query: 1607 IQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQK 1666
            +Q++   L+ Q     ++L++ +E  HKQ   +++   +++  +  L  +Q+ V   +  
Sbjct: 566  LQEKNHTLQEQVTQLTEKLKNQSES-HKQ--AQENLHDQVQEQKAHLRAAQDRVLSLETS 622

Query: 1667 CDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQE----LNNRLKKVQDE 1722
             ++ N  +  +K++V  L+ ++ A  E     E     Q+A +Q       N L+  Q E
Sbjct: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682

Query: 1723 LHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSL 1782
            L+  T +      K+   QE   + +   +E+++K   L +     E  I  +  D + +
Sbjct: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742

Query: 1783 QQENSRA----QENAKL---CETNIKELERQLQQYRE-------QMQQGQHMEANHYQKC 1828
            +    +A    Q+  +L    E    EL +QL+  +E        +Q+      +  QK 
Sbjct: 743  KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802

Query: 1829 QKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQK-----------KSTAKDCT 1877
             K E+E    K++ E L Q+   Q +E  +++     E+QK            ST KD  
Sbjct: 803  TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862

Query: 1878 FKP-----------------------DFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRW 1914
             K                        D E T KE +H  ++   NT       +  L + 
Sbjct: 863  SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922

Query: 1915 TQEPQPLE---EKWQHRVVE------QIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTE 1965
             +    L+      Q ++++      Q  KE Q Q  G   E ++S +   +       E
Sbjct: 923  KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ-QLQGNINELKQSSEQKKKQIEALQGE 981

Query: 1966 LQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVL-----TPLEIAKN 2020
            L+I       + + +E+E    Q L  +      Q+ A E E + VL        E  K 
Sbjct: 982  LKIA------VLQKTELENKLQQQLTQAA-----QELAAEKEKISVLQNNYEKSQETFKQ 1030

Query: 2021 KQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKK----GLEPETFQNFDG 2076
             Q D +   + L   +  + S EE +         L + D +      G + +  Q    
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKL--------SLAQEDLISNRNQIGNQNKLIQELKT 1082

Query: 2077 DHACSVRDDEFKFQGLRHTVTARQ-LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTK 2135
              A   +D   K Q L+    A Q + + K L  + +   +  L  +EE++    K +TK
Sbjct: 1083 AKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITK 1142

Query: 2136 AT-SIAGLYLESTKEKISFASAAERIIIDKM 2165
                +    LES KE  +   A + +I  K+
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173



 Score = 55.1 bits (131), Expect = 9e-07
 Identities = 150/800 (18%), Positives = 323/800 (40%), Gaps = 129/800 (16%)

Query: 309  ESHLENHKNVHRAIEEFESSLK---------EAKISEI--------QMTAPLKLTYAEKL 351
            ESH +  +N+H  ++E ++ L+         E  ++E+        +  + L +    K 
Sbjct: 589  ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648

Query: 352  HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARK 411
              L S  A       + + HLDT  N +     EL         ++     +    +  K
Sbjct: 649  ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL--------NKITTQLDQVTAKLQDK 700

Query: 412  KDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCV 471
            +++ ++L   L + +E   S+++  E+  LE    +L  ++       +     Q  Q +
Sbjct: 701  QEHCSQLESHLKEYKEKYLSLEQKTEE--LEGQIKKLEADSLEVKASKE-----QALQDL 753

Query: 472  EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ--RKYSCDRSSSIHKLEDLVQESMEEKE 529
            +Q  + NT   +    A E +  L   K+ +   R     +S ++  ++  + +  EEK+
Sbjct: 754  QQQRQLNT---DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810

Query: 530  ELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI----PIKAICDYRQIEITIYKDDEC 585
             L Q   T++      +T IQ +  N+   ++T++     +K   +    E++  KD   
Sbjct: 811  ILKQDFETLSQ-----ETKIQHEELNN--RIQTTVTELQKVKMEKEALMTELSTVKDKLS 863

Query: 586  VLANN--SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHES 643
             ++++  + +++++  +  G  A++           K   +L ++++ Q +N L    E 
Sbjct: 864  KVSDSLKNSKSEFEKENQKGKAAILDL--------EKTCKELKHQLQVQMENTLKEQKEL 915

Query: 644  HINM-KSVVSWHYLINEIDRIRASNVASIKTMLPG--EHQQVLSNLQSRFEDF------- 693
              ++ K   + H L  E++ ++   + +  T+     E QQ+  N+    +         
Sbjct: 916  KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975

Query: 694  ----------------LEDSQESQVFSGSDITQLEKE-VNVCKQYYQELLKSAEREEQEE 736
                            LE+  + Q+   +     EKE ++V +  Y+   KS E  +Q +
Sbjct: 976  EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE---KSQETFKQLQ 1032

Query: 737  SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDD 796
            S +    SE+   R  L++ E++L       L ++DL  +  +I  Q KL +EL+  K  
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKL------SLAQEDLISNRNQIGNQNKLIQELKTAKAT 1086

Query: 797  LGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--DKLKTVNLVLKN 854
            L   + K E+   +   +             LQ++ +  S+    +  +K K   +    
Sbjct: 1087 LEQDSAKKEQQLQERCKA-------------LQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133

Query: 855  TQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH-ALEDELQKA 913
             +  + + KL E     +   I +  N+++    L Q + E+  K      A+E E +  
Sbjct: 1134 CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193

Query: 914  KAISDEMFKTYKERDLDF-----DWHKEKADQLV--ERWQNVHVQIDNRLRDL-EGIGKS 965
            + + D++ K  +E   +F       H E  ++ V  ++ +    ++  ++  L E +G  
Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV 1253

Query: 966  LKYYRDTYHPL-------DDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1018
             K ++ +   +       DD   ++   +  +Q NQ E    L   L  +     EIE  
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE----GEIEKL 1309

Query: 1019 QSKMDECQKYAEQYSATVKD 1038
            Q+K+ E Q+  +  +A V++
Sbjct: 1310 QTKVLELQRKLDNTTAAVQE 1329


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  161 bits (407), Expect = 9e-39
 Identities = 294/1370 (21%), Positives = 566/1370 (41%), Gaps = 192/1370 (14%)

Query: 680  QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739
            Q++    + R E  L+  +  ++       Q  K     ++  Q+LLKS E+EE+ +   
Sbjct: 588  QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647

Query: 740  NLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGT 799
                 E R  RL+ E  E+RL ++++        HE   R  EQE  ++E E+ ++ + +
Sbjct: 648  RREQQERREQRLKREEEEERLEQRLKRE------HEEERR--EQELAEEEQEQARERIKS 699

Query: 800  ITNKCE-EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858
               K + +  S+A A  S                +VYS       + +      +  Q  
Sbjct: 700  RIPKWQWQLESEADARQS----------------KVYSRPRKQEGQRR------RQEQEE 737

Query: 859  EALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV----------------DEKRQV 902
            +   +  E +  EEE     +   E       QW++E                 +++ + 
Sbjct: 738  KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797

Query: 903  FHALEDELQKAKAISDEMFKTYK-------ERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
              A E + ++ + + +E  K  +       E++L F   +E+  Q  ER Q +  + D  
Sbjct: 798  LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF-LEEEEQLQRRERAQQLQEEEDGL 856

Query: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
              D E   +S +  RD       W  Q+E  +RK + +       L  QL +++ L+ E 
Sbjct: 857  QEDQER-RRSQEQRRD-----QKWRWQLEE-ERKRRRHTLYAKPALQEQLRKEQQLLQEE 909

Query: 1016 EMK-QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR--------RMQSS 1066
            E + Q +  E ++  EQ     ++ +LQ    + + + ++K   + R        ++Q  
Sbjct: 910  EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969

Query: 1067 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQ 1126
             + ++ E  + R R         +      +     EE E +R +E        D LQ++
Sbjct: 970  EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029

Query: 1127 KATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAEN-ELRKQQRNVEDISLQ 1185
            +  +L   +   ++ E ER   E ++ +   E+ L + RE     EL +Q R  E++  +
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE 1089

Query: 1186 K---IRAESEAKQYRRELETIVREKEAAERELERV----RQLTIEAEAKRAAVEENLLNF 1238
            +   +R E E K+ R+E E   RE+E  ++E E++    R+     E +R   EE  +  
Sbjct: 1090 EEQLLREEPE-KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148

Query: 1239 RNQ--LEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEK 1296
              +  L E    RR  E  L+R+     +L+Q++ +L+ E + KR  E E     +Q  +
Sbjct: 1149 EEEQLLREEPEKRRRQE--LERQYREEEELQQEEEQLLREEQEKRRQERE-----RQYRE 1201

Query: 1297 DLAFQKQVAEKQLKEKQKIELEARRKITEIQYTC-RENALPVCPITQATSCRAVTGLQQE 1355
            +   Q+Q      K KQ+   E +R   + Q+   +ENA+    +               
Sbjct: 1202 EEELQRQ------KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV--------------- 1240

Query: 1356 HDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLL-KDK-LDET 1413
            + K +  E  +Q+++    +R+++QD++ L  E    Q E+   +E+ R   +D+   E 
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE----QQERDREQERRRWQQRDRHFPEE 1296

Query: 1414 NNTLRCLKLELERKD---QAEKGYSQQLRELGRQLNQTTGKAEEAMQ-----EASDLKKI 1465
                R  + E +R+D   Q EK   ++ RE  R+  +T  K  E  Q     E   L++ 
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356

Query: 1466 KRNYQLELESLNHEKG--KLQREVDRITRAHAVA-------EKNIQHLNSQIHSFRDEKE 1516
            +R+ +   E L H++   K   E  R+ R            +   Q    Q+   RD K 
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416

Query: 1517 LERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKV 1576
             E  Q   R+    +++  +  EQ ++  + E++  ++ Q+L +E  +     E L Q+ 
Sbjct: 1417 REEEQQLSRQE---RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473

Query: 1577 EE------------------LTRQNNETKLMMQRIQA-ESENIVLEKQTI---QQRCEAL 1614
            EE                  L RQ  + K   Q +++ E E   LE++     QQR    
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533

Query: 1615 KIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQN----LVSEFKQKCDQQ 1670
              +    + Q R       +  K  ++ Q + +  E+ L++ +      + E K +  +Q
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593

Query: 1671 NIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQL------QQAQVQELNNRLKKVQDELH 1724
                   ++++R    +    +E  R+  +  QL      QQ   QE + +  + + +L 
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653

Query: 1725 LKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQ 1784
             +  E+Q+ H +   F+EE    ++  E+  ++ E+  + K   E             ++
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER--DRKFREEEQ------QLRRQER 1705

Query: 1785 ENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVEN 1844
            E    QE  +L    ++   R+ +Q R++ +Q Q      Y+K   LE+E +  +RE + 
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI--LEEEQLRPEREEQQ 1763

Query: 1845 L-KQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHL 1903
            L +Q+ D++ +E E QL   + E Q +S   D  F+ + ++             R    L
Sbjct: 1764 LRRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFREEEQLR----------QEREEQQL 1812

Query: 1904 HPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQ 1953
             P  R    RW +E   LEE+ + R+ ++  ++ + +   A  EK + ++
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQ-EQRLRQERDRQYRAEEQFATQEKSRREE 1861



 Score =  155 bits (391), Expect = 7e-37
 Identities = 211/1025 (20%), Positives = 450/1025 (43%), Gaps = 107/1025 (10%)

Query: 978  DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK 1037
            DW+++ E T+R  QE + +  K    +  +++ L  E E ++ + +  ++   +     +
Sbjct: 456  DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515

Query: 1038 DYELQTMTYRAMVDSQQKSPVKRRRMQSSA-DLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
            +  L+       +  + +S  + RR Q    + +++   + R         + +  +   
Sbjct: 516  EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575

Query: 1097 DSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSR 1156
            D L + EEE  ++  +  +       L+R++   LE  +   +  + E    E ++Q  +
Sbjct: 576  DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635

Query: 1157 VEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQ-YRRELETIVREKEAAERELE 1215
             EE+     E  + +LR++Q+   +  L++   E   +Q  +RE E   RE+E AE E E
Sbjct: 636  SEEQ----EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691

Query: 1216 RVR------------QLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSL 1263
            + R            QL  EA+A+++ V       R + +E    R+  E+  +R++  L
Sbjct: 692  QARERIKSRIPKWQWQLESEADARQSKVYS-----RPRKQEGQRRRQEQEEKRRRRESEL 746

Query: 1264 NDLEQQK---NKLMEELRRK------------------------RDNEEELLKLIKQMEK 1296
               E+++    +  EE RR                         R+  E  L+  ++ ++
Sbjct: 747  QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806

Query: 1297 DLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEH 1356
            +  F  +  EK+ + +Q+ E E      E+Q+   E  L      Q        GLQ++ 
Sbjct: 807  EQRFLPEEEEKEQRRRQRREREK-----ELQFLEEEEQLQRRERAQQLQ-EEEDGLQEDQ 860

Query: 1357 DKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNT 1416
            ++++++E  Q+ D+      + E+  R  T         K + +E+ R  +  L E    
Sbjct: 861  ERRRSQE--QRRDQKWRWQLEEERKRRRHTL------YAKPALQEQLRKEQQLLQEEEEE 912

Query: 1417 LRCLKLELERKDQAEKGY--SQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE 1474
            L+  + E  R+ + E+ Y   +QL++   QL +   +     +     +K K+  Q E +
Sbjct: 913  LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972

Query: 1475 SLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQF 1534
             L  E  K +R+ +R  +     E+ +Q    Q+   R+E+E  R Q  +R+    K++ 
Sbjct: 973  LLGEEPEKRRRQ-EREKKYRE--EEELQQEEEQL--LREEREKRRRQEWERQY-RKKDEL 1026

Query: 1535 EKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQR-I 1593
            ++  EQLL+  + ++   ++ ++  EE E   E  ++L ++ E   RQ  E +   +  +
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086

Query: 1594 QAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHL---HKQTKTEQDFQRKIKCLE 1650
            Q E E ++ E+   ++R E  +   +  +++L+   E L    ++ +  Q+ +R+ +  E
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCRE--EEELQQEEEQLLREEREKRRRQELERQYREEE 1144

Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQ-NTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQV 1709
            E   + + L+ E  +K  +Q +  Q   ++E++    +L   ++EKRR E++ Q ++ + 
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204

Query: 1710 QELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK-QSAEEFRKKMEKLMESKVIT 1768
             +   R ++ +DE     ++ Q    K    ++     K +  E+FR+  +  +  +  +
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ-S 1263

Query: 1769 ENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKC 1828
            + D+  +    +  QQE  R QE  +      ++ +R   +  EQ+++ +  EA    + 
Sbjct: 1264 QQDLQHL----LGEQQERDREQERRRW-----QQRDRHFPE-EEQLEREEQKEAKRRDRK 1313

Query: 1829 QKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKE 1888
             + E +L+ ++RE +  +Q+ D++ +E E QL+  + E   +   +D  F+ +       
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFRE-EEQLLQEREEQPLRRQERDRKFREE------- 1365

Query: 1889 CQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEK 1948
                 EL  +  G         L R  +E + L+E+ Q R  E   +E Q +       +
Sbjct: 1366 -----ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE---REQQLRQDRDRKFR 1417

Query: 1949 EKSQQ 1953
            E+ QQ
Sbjct: 1418 EEEQQ 1422



 Score =  149 bits (377), Expect = 3e-35
 Identities = 282/1390 (20%), Positives = 597/1390 (42%), Gaps = 171/1390 (12%)

Query: 680  QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEK--EVNVCKQYYQELLKSAEREEQEES 737
            +Q L   Q    D+L+  +E++        Q  K  +    ++ + +L +   RE+QE  
Sbjct: 444  EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503

Query: 738  VYNLYIS--EVRNIRLRLENCEDRLIRQIRTPL----ERDDLHESVFRITEQ-------- 783
               L     E R  RL+ +  E+RL +++R+      E+++  E + +  E+        
Sbjct: 504  EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563

Query: 784  -EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL-----RSELNVVLQNMNQVYSM 837
             ++LK+E E  +D L     + EE   Q         L     R E+  + Q   +   +
Sbjct: 564  EQRLKREQEERRDQL---LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620

Query: 838  SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
                 ++ +   L+    Q      +L   +    E  +  +   E L   LK+   E +
Sbjct: 621  KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR---EHE 677

Query: 898  EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKE-KADQLVERWQNVHVQIDNRL 956
            E+R+     E+E ++A+       +  K R   + W  E +AD    +  +   + + + 
Sbjct: 678  EERREQELAEEEQEQAR-------ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730

Query: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1016
            R  E   K  +   +       W Q+ E   R+ QE +     T   Q  ++       E
Sbjct: 731  RRQEQEEKRRRRESEL-----QW-QEEERAHRQQQEEEQRRDFTWQWQAEEKS------E 778

Query: 1017 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADL-IIQEFM 1075
              + ++       EQ    ++  E Q    R + + ++K   +R+R +   +L  ++E  
Sbjct: 779  RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838

Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ----RQKATVL 1131
             L+ R  A      Q ++   D L+  E++E +R +E      +   L+    R++ T+ 
Sbjct: 839  QLQRRERA------QQLQEEEDGLQ--EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890

Query: 1132 ENSKLTGKISELERMVAELKKQKSRVEEELPKVRE-----AAENELRKQQRNVEDISLQK 1186
                L  ++ + ++++ E +++  R E E  + +E       E +L++++  +     +K
Sbjct: 891  AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950

Query: 1187 IRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQL--EE 1244
             R +   +QYR++ +   +E++    E E+ R+   +   K+   EE L     QL  EE
Sbjct: 951  RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR---QEREKKYREEEELQQEEEQLLREE 1007

Query: 1245 NTFTRR-------TLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQM--E 1295
                RR         +D L++++  L   E++K +L E  R+ R+ EEEL +  +Q+  E
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEELQQEEEQLLGE 1066

Query: 1296 KDLAFQKQVAEKQLKEKQKIELEARRKI-TEIQYTCRENALPVCPITQATSCRAVTGLQQ 1354
            +    ++Q  E+Q +++++++ E  + +  E +   R+     C   +         L++
Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126

Query: 1355 EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN 1414
            E +K++ +EL++Q  E     ++ EQ +RE   +    +LE+   EE      ++L +  
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE------EELQQEE 1180

Query: 1415 NTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE 1474
              L  L+ E E++ Q  +   ++  EL RQ  +   + E+   + SDLK     +Q E E
Sbjct: 1181 EQL--LREEQEKRRQERERQYREEEELQRQKRKQRYRDED---QRSDLK-----WQWEPE 1230

Query: 1475 SLN-------HEKGKLQ---REVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQ 1524
              N       + KG+     R+++        +++++QHL  +      E+E  R    Q
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR---WQ 1287

Query: 1525 RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNN 1584
            ++  H  E+ +   E+  +  + ++++ ++ Q L EE E+        K++ +E  R+  
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE--------KRRRQETDRKFR 1339

Query: 1585 ETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFK----DQLRSTNEHLHKQTKTEQ 1640
            E + ++Q  + E + +  +++  + R E L+ Q  G K    +Q     E   K  K EQ
Sbjct: 1340 EEEQLLQ--EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ 1397

Query: 1641 DFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQ 1700
                +++C E +    Q+   +F++  ++Q +  Q   ++ R    ++   + E++  E+
Sbjct: 1398 ----QLRCQEREQQLRQDRDRKFRE--EEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451

Query: 1701 KVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRK--KM 1758
            + QL+Q + ++        ++E  L+  EEQ  HR     QE   KF +  ++ R+  + 
Sbjct: 1452 EQQLRQERHRKFR------EEEQLLQEREEQQLHR-----QERDRKFLEEEQQLRRQERD 1500

Query: 1759 EKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQ 1818
             K  E ++ ++         F+  +Q+  R Q   K  +   ++L RQ +  + +  + +
Sbjct: 1501 RKFREQELRSQEP----ERKFLEEEQQLHRQQRQRKFLQEE-QQLRRQERGQQRRQDRDR 1555

Query: 1819 HMEANHYQKCQKLEDELIAQKR-------EVENLKQKMDQQIKEHEHQLVLLQCEIQKKS 1871
                    + ++ E +L  Q+R       E +  +Q+ +++  E E QL   + + Q+  
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ-QQLR 1614

Query: 1872 TAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTP------RSPLLR------WTQEPQ 1919
              +D  F+ D ++  +  +       R+   L   P      R   LR      + +E Q
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674

Query: 1920 PLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQ-TSTELQITFDETNPITR 1978
             L+E  + ++  Q  ++ +F+     L +++ ++ + +   Q    EL+  F E   + +
Sbjct: 1675 LLQEGEEQQLRRQ-ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733

Query: 1979 LSEIEKIRDQ 1988
             +E E++R Q
Sbjct: 1734 ETEQEQLRRQ 1743



 Score =  148 bits (374), Expect = 6e-35
 Identities = 213/1030 (20%), Positives = 455/1030 (44%), Gaps = 114/1030 (11%)

Query: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1061
            AT L+++K   +  + K+S + + ++  +Q     +D +L+    +     +Q+   +R 
Sbjct: 92   ATGLDEEKR--ARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ--ERE 147

Query: 1062 RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK--ETSEHGAY 1119
              +       QE ++ R R      L  Q  ++     +R EEE+++ CK  ET E    
Sbjct: 148  LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207

Query: 1120 SDLLQRQKATVLENSKLTGKISELERMVAELKKQKSR------VEEELPKVREAAENELR 1173
              L +R+             + EL R   E K+Q+ R       +EE  K     E  LR
Sbjct: 208  EQLRRRE-------------LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254

Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELE--TIVREKEAAERELERVRQLTIEAEAKRAAV 1231
            K++  +++   Q+ R   E ++  R+LE   + RE++  E++ +R+R+   E + +R   
Sbjct: 255  KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR---EQQLRRKQE 311

Query: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI 1291
            EE     R Q EE    +   E   +R++  L    +Q+ +  ++LRR+++ E    +L 
Sbjct: 312  EER----REQQEERREQQERREQQEERREQQLR--REQEERREQQLRREQEEERREQQLR 365

Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKI----ELEARRKITEIQYTCRENALPVCPITQATSCR 1347
            ++ E++   Q+   E+QL+ +Q++    +L   +++   Q   RE  L      +    R
Sbjct: 366  REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL-----RREQQLR 420

Query: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLK 1407
                L++E ++++ E+  +Q  E      K EQ+ R    +             K +L +
Sbjct: 421  REQQLRREQEEERHEQKHEQ--ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 1408 DKLDETNNTLRCLKLELERKDQAEKGYSQQLR--------------ELGRQLNQTTGKAE 1453
            D+ +E     R LKLE E + + ++   QQLR              E   +L Q     +
Sbjct: 479  DQEEERRE--RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536

Query: 1454 EAMQEASDLKK--IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
            +  +E  + ++  +KR  +  LE    E+ +L+RE +   R   + ++  +    ++   
Sbjct: 537  QLRREQEERREQLLKREEEKRLEQERREQ-RLKREQEE--RRDQLLKREEERRQQRLKRE 593

Query: 1512 RDEK--------ELERLQICQRKSDHLK--EQFEKSHEQLLQNIKAEKENNDKIQRLNEE 1561
            ++E+        E+ERL+  +R+   LK  E  E+  +QLL++ + E+    +++R  +E
Sbjct: 594  QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653

Query: 1562 LEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLE--KQTIQQRCEALKIQAD 1619
              +     E  ++++E+  ++ +E +   Q +  E +    E  K  I +    L+ +AD
Sbjct: 654  RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713

Query: 1620 GFKDQLRSTNEHLHKQTKTEQDFQRK------IKCLEEDLAKSQNLVSEFKQKCDQQNII 1673
              + ++ S       Q + ++  +++      ++  EE+ A  Q    E ++    Q   
Sbjct: 714  ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773

Query: 1674 IQNTKKEVRNLNA--------ELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725
             + +++  + L+A        E     EE+++ EQ+   ++ + ++   + ++ + EL  
Sbjct: 774  EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833

Query: 1726 KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFV----- 1780
               EEQ+  R+     +E     Q  +E R+  E+  + K   + +    R         
Sbjct: 834  LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893

Query: 1781 SLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKR 1840
            +LQ++  + Q+  +  E  ++  ER+ ++ +EQ +Q +  E    ++ Q L +E   ++R
Sbjct: 894  ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 1841 EVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQ---------- 1890
            +    + + D+++++ E QL+  + E +++   ++  ++ + E+  +E Q          
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPE-KRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012

Query: 1891 -HSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEK-WQHRVVEQIPKEVQFQPPGAPLEK 1948
                E   R    L       LLR  +E + L+E+  Q+R  E++ +E + Q  G   E 
Sbjct: 1013 RQEWERQYRKKDELQ-QEEEQLLREEREKRRLQERERQYREEEELQQEEE-QLLGEERET 1070

Query: 1949 EKSQQCYSEY 1958
             + Q+   +Y
Sbjct: 1071 RRRQELERQY 1080



 Score =  137 bits (346), Expect = 1e-31
 Identities = 247/1189 (20%), Positives = 486/1189 (40%), Gaps = 146/1189 (12%)

Query: 907  EDELQKAKAISDEMF-----KTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961
            E++ Q+ +   D +F     K +++R+      +EK  +   + Q    + + +LR LE 
Sbjct: 224  EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283

Query: 962  IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021
              + L+  R         +++ +  +RK +E + E  +    Q  Q++    E   +Q  
Sbjct: 284  --QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ--QERREQQEERREQQL 339

Query: 1022 MDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY 1081
              E ++  EQ     ++ E +    R   + +++    RR  Q   +  ++    LR   
Sbjct: 340  RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399

Query: 1082 TALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKIS 1141
                    +  +      +   E++++R +E   H    +  +R++    E  +    + 
Sbjct: 400  QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459

Query: 1142 ---ELERMVAELKKQ---KSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQ 1195
               E ER   E +KQ   + + EE   +  +  E E R+QQ   E    Q++R E E ++
Sbjct: 460  REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE----QQLRREQEERR 515

Query: 1196 YRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDH 1255
             +R       E+E  ++ L   +QL  E E +R    E LL    + EE    +   E  
Sbjct: 516  EQRLKRQ--EEEERLQQRLRSEQQLRREQEERR----EQLLK---REEEKRLEQERREQR 566

Query: 1256 LKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQ-- 1313
            LKR+     D   ++ +   + R KR+ EE L + +K+ E +   Q++  E++LK ++  
Sbjct: 567  LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626

Query: 1314 ---------KIELEARR--KITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAE 1362
                       E E RR  ++   Q   RE  L      +    R    L++EH++++ E
Sbjct: 627  EERRQQLLKSEEQEERRQQQLRREQQERREQRLK----REEEEERLEQRLKREHEEERRE 682

Query: 1363 ELKQQVDELTAANR------------KAEQDMRELTYELNALQLE----KTSSEEKARLL 1406
            +   + ++  A  R            ++E D R+        + E    +   EEK R  
Sbjct: 683  QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 1407 KDKL--DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQ----------LNQTTGKAEE 1454
            + +L   E     R  + E +R+D   +  +++  E GRQ            +   +AEE
Sbjct: 743  ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802

Query: 1455 AMQ----------EASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL 1504
              Q          E    ++ +R  + EL+ L  E+   +RE  +  +      +  Q  
Sbjct: 803  RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862

Query: 1505 NSQIHSFRDEKELERLQICQRKSDH-------LKEQFEKSHEQLLQNIKAEKENNDKIQR 1557
                   RD+K   +L+  +++  H       L+EQ  K  +QLLQ  + E +  ++ +R
Sbjct: 863  RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK-EQQLLQEEEEELQREEREKR 921

Query: 1558 LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQR---------IQAESENIVLEKQTIQ 1608
              +E E+     E L+Q+ E+L R+  E +   +R         +Q + E ++ E+   +
Sbjct: 922  RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981

Query: 1609 QRCEALKIQADGFKDQLRSTNEHL---HKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665
            +R E  K   +  +++L+   E L    ++ +  Q+++R+ +  +E   + + L+ E ++
Sbjct: 982  RRQEREKKYRE--EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039

Query: 1666 KCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ---QAQVQELNNRLKKVQDE 1722
            K   Q    Q  ++E      E    +E + R  Q+++ Q   + ++Q+   +L + + E
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099

Query: 1723 LHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSL 1782
               +   E+    +  L QEE    +   EE  K+  + +E +   E ++       +  
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLR---EEREKRRRQELERQYREEEEVQQEEEQLLRE 1156

Query: 1783 QQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREV 1842
            + E  R Q           ELER   QYRE+ +  Q  E    ++ +K   E   Q RE 
Sbjct: 1157 EPEKRRRQ-----------ELER---QYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202

Query: 1843 ENL-KQKMDQQIKEHEHQLVL-LQCEIQKKSTAKD----CTFKPDFEM-TVKECQHSGEL 1895
            E L +QK  Q+ ++ + +  L  Q E +K++  +D    C  + + +   +++ Q     
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262

Query: 1896 SSRNTGHL-----HPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEK 1950
            S ++  HL              RW Q  +   E+ Q    EQ  KE + +   +  EK+ 
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ--KEAKRRDRKSQEEKQL 1320

Query: 1951 SQQCYSEYFSQTSTELQITFD-------ETNPITRLSEIEKIRDQALNN 1992
             ++   E   +  T+ +   +       E  P+ R     K R++ L +
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369



 Score =  124 bits (311), Expect = 1e-27
 Identities = 209/1014 (20%), Positives = 426/1014 (42%), Gaps = 113/1014 (11%)

Query: 1058 VKRRRMQSSADLIIQEFMDLRTR-------YTALVTLMTQYIKFAGDSLKRLEEEEIKRC 1110
            ++R     + DLI+ E +DL +        +   +  + Q   +A      L+EE+  RC
Sbjct: 45   LRRPHDPKTVDLIL-ELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARC 103

Query: 1111 KETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEE-ELPKVREAAE 1169
                  G  S L  R++    +  +   +  +LE    + ++QK + +E EL +  E +E
Sbjct: 104  D-----GKESLLQDRRQEE--DQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156

Query: 1170 NELRKQQRNVE--DISLQKIRAESEAKQYRR------------ELETIVREKEAAERELE 1215
             + R +QR+ +  D  L + R E + ++ RR            E E    E++   REL 
Sbjct: 157  KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216

Query: 1216 RVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRT--------LEDHLKRKDLSLNDLE 1267
             +R+   E + ++    ++ + F+ + E+    R T        L++   ++   L + E
Sbjct: 217  ELRRKGREEKQQQRRERQDRV-FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275

Query: 1268 QQKNKL-MEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
            +Q  KL  +ELRR+R  EE+  + +++ E+ L  +KQ  E++ +++++ E + RR   E 
Sbjct: 276  EQLRKLERQELRRERQEEEQQQQRLRR-EQQLR-RKQEEERREQQEERREQQERR---EQ 330

Query: 1327 QYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELT 1386
            Q   RE  L      +    R    L++E ++++ E+  ++  E      + EQ +R   
Sbjct: 331  QEERREQQL-----RREQEERREQQLRREQEEERREQQLRREQE----EERREQQLRREQ 381

Query: 1387 YELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN 1446
                  QL +     + + L+ +           + +L R+ Q  +   ++  E   +  
Sbjct: 382  QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 1447 QTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNS 1506
            +   + +   +E  D   +KR  + E       K +L+R+ +   R   +  +  +    
Sbjct: 442  RREQRLKREQEERRDW--LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 1507 QIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSN 1566
            Q    R E++L R Q  +R+   LK Q E+  E+L Q +++E++   + +   E+L K  
Sbjct: 500  Q---ERREQQLRREQE-ERREQRLKRQEEE--ERLQQRLRSEQQLRREQEERREQLLKRE 553

Query: 1567 ECAEMLKQKVEE-LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQL 1625
            E   + +++ E+ L R+  E +  + + + E     L+++  ++  + LK +     +Q 
Sbjct: 554  EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613

Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLN 1685
                + L ++   E+  Q+ +K  E++  + Q L  E +++ +Q+       ++E   L 
Sbjct: 614  ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR----LKREEEEERLE 669

Query: 1686 AELNASKEEKRRGEQKVQLQQAQVQE-LNNRLKKVQDELHLKTIEEQMTHRKMVLF---- 1740
              L    EE+RR ++  + +Q Q +E + +R+ K Q +L     E +   R+  ++    
Sbjct: 670  QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL-----ESEADARQSKVYSRPR 724

Query: 1741 QEESGKFKQSAEEFRKKMEKLM----ESKVITENDISGIRLDFVSLQQENSRAQENAKLC 1796
            ++E  + +Q  EE R++ E  +    E +   +      R DF    Q   +++   +  
Sbjct: 725  KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784

Query: 1797 ----------ETNIKELERQLQQYR-----EQMQQGQHMEANHYQKCQKLEDELIAQKRE 1841
                      E  ++  ERQ ++ R     E+ +Q +       ++ Q LE+E   Q+RE
Sbjct: 785  SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 1842 VENLKQKMDQQIKEHEH----------QLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQH 1891
                 Q+ +  ++E +           Q    Q E ++K        KP  +  +++ Q 
Sbjct: 845  RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ- 903

Query: 1892 SGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEV----QFQPPGAPLE 1947
              +L       L    R    R  QE Q  EE+   +  EQ+ +E     + Q       
Sbjct: 904  --QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961

Query: 1948 KEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQD 2001
            K+K  Q   E       E +   +         E+++  +Q L   R   R Q+
Sbjct: 962  KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015



 Score =  115 bits (288), Expect = 6e-25
 Identities = 220/1084 (20%), Positives = 465/1084 (42%), Gaps = 121/1084 (11%)

Query: 710  QLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE 769
            QL KE  + ++  +EL +    + + +     Y  E +     L+  E++L+R+ R    
Sbjct: 898  QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ-----LQQEEEQLLREEREKRR 952

Query: 770  RDDLH-----ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824
            R +       +   +  E++ L +E E+ +        + EE   Q         LR E 
Sbjct: 953  RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ----LLREER 1008

Query: 825  NVVLQNMNQVYSMSSTYIDKLKTVNLVL-------KNTQAAEALVKLYETKLCEEEAVIA 877
                +   Q +       D+L+     L       +  Q  E   +  E    EEE ++ 
Sbjct: 1009 E---KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 878  DKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEK 937
            ++          +Q+R E + +++    L +E +K +    E  +  +E +L     +++
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER-QCREEEEL-----QQE 1119

Query: 938  ADQLV--ERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP 995
             +QL+  ER +    +++ + R+ E + +  +       P     Q++E   R+ +E Q 
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQ 1178

Query: 996  ENSKTLATQLNQ-----QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
            E  + L  +  +     ++    E E+++ K    Q+Y ++   +   ++ +     A+ 
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRK--QRYRDEDQRSDLKWQWEPEKENAVR 1236

Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRC 1110
            D+  K   K R  +    L   +  D +++      L        G+  +R  E+E +R 
Sbjct: 1237 DN--KVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL--------GEQQERDREQERRRW 1286

Query: 1111 KETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAA-- 1168
            ++   H    + L+R++    E  +   K  E ++++ E +++K R +E   K RE    
Sbjct: 1287 QQRDRHFPEEEQLEREEQK--EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL 1344

Query: 1169 -----ENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIE 1223
                 E  LR+Q+R+      +++R + + +++  E E  +R +E   + L+  +QL  +
Sbjct: 1345 LQEREEQPLRRQERD-RKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEEQQLRCQ 1402

Query: 1224 AEAKRAAVEENLLNFRNQLEENTFTR-------RTLEDHLKRKDLSLNDLEQQKNKLMEE 1276
             E ++   ++    FR   EE   +R       R  E  ++R++     LE+++ +L +E
Sbjct: 1403 -EREQQLRQDRDRKFRE--EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ-QLRQE 1458

Query: 1277 LRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR-RKITEIQYTCRENAL 1335
              RK   EE+LL+   + E+    +++   K L+E+Q++  + R RK  E +   +E   
Sbjct: 1459 RHRKFREEEQLLQ---EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515

Query: 1336 PVCPITQAT--SCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQ 1393
                  Q      R    LQ+E   ++ E  +Q+  +     R+ EQ    L  E    Q
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ----LRQEREEQQ 1571

Query: 1394 LEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAE 1453
            L +   + K RL + K+               R+ + E+ + +  ++L RQ  Q   + E
Sbjct: 1572 LSRQERDRKFRLEEQKV---------------RRQEQERKFMEDEQQLRRQEGQQQLRQE 1616

Query: 1454 EAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD 1513
               +   D + ++   + +L     ++  L+ E  ++ R     E+ ++H   +   FR+
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEE-PQLRRQER--EQQLRH--DRDRKFRE 1671

Query: 1514 EKEL----ERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECA 1569
            E++L    E  Q+ +++ D    +F +  +QL +  +  K   ++ Q   +ELE+     
Sbjct: 1672 EEQLLQEGEEQQLRRQERDR---KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE 1728

Query: 1570 EMLKQKVEE--LTRQNNETKLMMQ-RIQAESENIVLEKQTIQQRC-EALKIQADGFKDQL 1625
            E L+Q+ E+  L RQ    K++ + +++ E E   L +Q   ++  E  +++ +  + QL
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL 1788

Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK---KEVR 1682
            RS  E   K  + EQ  Q +    EE   + Q    +++ + +Q  +  Q  +   +  R
Sbjct: 1789 RS-QESDRKFREEEQLRQER----EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDR 1843

Query: 1683 NLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQE 1742
               AE   + +EK R E++   Q+ + +    R +K+++E   +  +E+  HR++   + 
Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903

Query: 1743 ESGK 1746
            + GK
Sbjct: 1904 QEGK 1907



 Score = 76.3 bits (186), Expect = 4e-13
 Identities = 129/592 (21%), Positives = 252/592 (42%), Gaps = 62/592 (10%)

Query: 893  RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 952
            R E D K +    L  + Q  K + +E     +ER+  F   +E+  +  ER Q +    
Sbjct: 1355 RQERDRKFRE-EELRHQEQGRKFLEEEQRLRRQERERKF-LKEEQQLRCQEREQQLRQDR 1412

Query: 953  DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1012
            D + R+ E   +  +  RD     ++   + +  +RK  E + +  +    +  +++ L+
Sbjct: 1413 DRKFREEEQ--QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470

Query: 1013 SEIEMKQ-SKMDECQKYAE---QYSATVKDYELQTMTYRAMVDS----QQKSPVKRRRMQ 1064
             E E +Q  + +  +K+ E   Q     +D + +    R+        +++  + R++ Q
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530

Query: 1065 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAG------------------DSLKRLEEEE 1106
                  +QE   LR +         +  KF                    D   RLEE++
Sbjct: 1531 RK---FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 1107 IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVRE 1166
            ++R ++  +       L+RQ+       +   K  E E+++ E ++Q+   +E   K  E
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 1167 AAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEA 1226
              E +LR+Q+R       Q++R + + K +R E + +   +E   R  ER R+   E + 
Sbjct: 1648 E-EPQLRRQERE------QQLRHDRDRK-FREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699

Query: 1227 -KRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKN--KLMEELRRKRDN 1283
             +R   E   L    QL      R+  E+   R++     L +Q+   K++EE + + + 
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 1284 EEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIEL-EARRKITEIQYTCRENALPVCPITQ 1342
            EE+ L+   + E+D  F+++   +Q +E+Q++   E+ RK  E +   +E         +
Sbjct: 1760 EEQQLR---RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER--------E 1808

Query: 1343 ATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEK 1402
                R     QQ   K + EE + Q++E     R+ E+D +    E  A Q EK+  EE+
Sbjct: 1809 EQQLRP----QQRDGKYRWEEEQLQLEEQEQRLRQ-ERDRQYRAEEQFATQ-EKSRREEQ 1862

Query: 1403 ARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEE 1454
                +++        R L+ E  R+ Q E+   +Q+ E+  Q  +  G+  E
Sbjct: 1863 ELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914



 Score = 33.1 bits (74), Expect = 3.7
 Identities = 42/216 (19%), Positives = 88/216 (40%), Gaps = 23/216 (10%)

Query: 251 QTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVES 310
           Q LK  +  + L +    +Q L  E+   +  + LL   +E +++ +R E       ++ 
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERR--EQLLKREEEKRLEQERRE-----QRLKR 569

Query: 311 HLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQER 370
             E  ++     EE     +  +  E ++   LK    E+L + E +  +L      +ER
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629

Query: 371 HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 430
               L +             E+ ++++  +  ER     ++++    L + L ++ E  +
Sbjct: 630 RQQLLKSEEQE---------ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680

Query: 431 SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 466
             QE+AE+   E   AR  I+    +   +W W L+
Sbjct: 681 REQELAEE---EQEQARERIK----SRIPKWQWQLE 709


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  159 bits (401), Expect = 5e-38
 Identities = 335/1709 (19%), Positives = 684/1709 (40%), Gaps = 218/1709 (12%)

Query: 265  SSLLDQNLTEEEINM--KFVQDLLN-WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA 321
            +++L Q L   E+N   K VQ+ L  ++ + Q ++D  +   +   VES  +  +     
Sbjct: 2    AAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFE----- 56

Query: 322  IEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNF--- 378
            IE+  S  +E  ++E +    L+L   +  ++L++   K       Q+R++     F   
Sbjct: 57   IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116

Query: 379  ---VSRATNELIWLNEKEEEEVAY---DWSERNTNIARKKDYHAELMRELDQKEENIKSV 432
               +     +LI  NE+  +E+ Y   D    N  +        EL  +LD+ + +  SV
Sbjct: 117  KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176

Query: 433  QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 492
            +   ++L  E              ++T+   +L L +             E  N+  E  
Sbjct: 177  KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR-------------EKGNEILELK 223

Query: 493  DYLRNLKDAIQR---KYSCDRSSSIH---KLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
              L N K+ + R   + +  ++S+ H    +EDL+ +  E KE+    +    N +    
Sbjct: 224  CNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHI 283

Query: 547  TIIQL-KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNE 605
             +  L K    D   K++   +A+ +  ++        E   AN + +     +  + ++
Sbjct: 284  KLSNLYKSAADDSEAKSNELTRAVEELHKLL------KEAGEANKAIQDHLLEVEQSKDQ 337

Query: 606  AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
                          KE ++   R+E++ +N   L   S    K  +       E+  +  
Sbjct: 338  M------------EKEMLEKIGRLEKELENANDLL--SATKRKGAILSE---EELAAMSP 380

Query: 666  SNVASIKTMLPGEHQQVLSNLQSRFED--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 723
            +  A  K + PG     L N     +D   LE  +  ++    D  ++ KEV       +
Sbjct: 381  TAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLD--EIVKEVEAKAPILK 438

Query: 724  ELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQ 783
               +  ER ++  +  ++ + +      RL+   D+  +Q  + LERD+    +      
Sbjct: 439  RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQ-SSVLERDNRRMEIQVKDLS 497

Query: 784  EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843
            ++++  L  L++  G    + EE  S   +SSS         V+ Q++     +S   I+
Sbjct: 498  QQIRVLLMELEEARGNHVIRDEEVSSADISSSS--------EVISQHL-----VSYRNIE 544

Query: 844  KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN-----IENLISTLKQWRSEVDE 898
            +L+      +N +   AL +L ET+  EE+   + K       +E+ ++ L+Q R     
Sbjct: 545  ELQQ-----QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQH 599

Query: 899  KRQVFHALEDELQKAKAISDEMF--------KTYKERDLDFDWHKEKADQLVERWQNVHV 950
            + Q+  ++  +    + +  +           +  +  L     +    Q V     V V
Sbjct: 600  QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPV 659

Query: 951  QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKM 1010
                   + +   K L+   + Y       ++ +    KIQ  Q E  +   T L  Q  
Sbjct: 660  IESTEAIEAKAALKQLQEIFENY-------KKEKAENEKIQNEQLEKLQEQVTDLRSQNT 712

Query: 1011 LVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLI 1070
             +S      +++D   K  E     V+ Y       R +    +++       Q    +I
Sbjct: 713  KIS------TQLDFASKRYEMLQDNVEGYR------REITSLHERNQKLTATTQKQEQII 760

Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130
                 DLR     L     +      ++LK+  E+E+ +  E         LL  Q+   
Sbjct: 761  NTMTQDLRGANEKLAVAEVR-----AENLKK--EKEMLKLSEVRLSQQRESLLAEQRGQN 813

Query: 1131 LENSKLTGKISELERMVAELKKQKS----RVEEELPKVREAAENELRKQQRNVEDISLQK 1186
            L  + L      LER   E K++ S    ++E E+  +++  ENE+ ++     ++ +Q 
Sbjct: 814  LLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQL 873

Query: 1187 IRAESEAKQYRRELETIVREKEAAERELE-RVRQLTIEAEAKRAAVEENLLNFRNQLEEN 1245
            +         +R+L+T        E  L    ++L   A+ + A ++++L N   Q+   
Sbjct: 874  LDT-------KRQLDT--------ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918

Query: 1246 TFTRRTLEDHLKRKDLS-----LNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAF 1300
            +  R        ++D+      L   E+Q N L E L+    N E+   ++  +E+ L  
Sbjct: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNK 978

Query: 1301 QKQVAEK-------QLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353
            +KQV E+       +LKE  + + +  +K+ E++   +E         Q    RA+  ++
Sbjct: 979  EKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE--------LQDDKRRAIESME 1030

Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDET 1413
            Q+       ELK+    L++   + ++ ++  +  L+  Q  +   +E+A++  +  ++ 
Sbjct: 1031 QQ-----LSELKK---TLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY 1082

Query: 1414 NNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASD--------LKKI 1465
               L     ++E   QA K    ++  + + L +TT KAE  + E           LK  
Sbjct: 1083 ERELMLHAADVEAL-QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDE 1141

Query: 1466 KRNYQLELESLNHEKGKLQREVDRIT-RAHAVAEKNIQ---HLNSQIHSFRDEKELERLQ 1521
                    E L  +   L  ++++++ +  A  ++ +Q   +++        E+ LE L+
Sbjct: 1142 VSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR 1201

Query: 1522 ICQRKSDHLKEQFEKSHEQLL---QNIK-AEKENNDKIQRLNEELEKSNECAEMLKQKVE 1577
              +R+ +  + +FE +  + L   Q ++  E+E  +    LN E EK    A+ + Q  E
Sbjct: 1202 FIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE 1261

Query: 1578 ELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637
             + +      +M        E   LE+   Q + +  K++ D     L+  N  L +++ 
Sbjct: 1262 LMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDIL--PLQEANAELSEKSG 1319

Query: 1638 TEQDFQRKIKCLEEDL----AKSQNLVSEFKQKCDQQNIIIQNTK----KEVRNLNAELN 1689
                 Q + K LEED+    A++Q+LVS+ K    ++   + + K    K ++ L  E+ 
Sbjct: 1320 M---LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376

Query: 1690 ASKEEKRRGEQKVQLQQAQVQELNNRLKKV-------QDELHLKTIEEQMTHRKMVLFQE 1742
              K E  R    +   Q  +Q L   L KV       Q +L  K I+ Q   + +   ++
Sbjct: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK 1436

Query: 1743 ESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKE 1802
               ++K   EE + + +K+ME+   +  D     +      QE    +E     ET  K 
Sbjct: 1437 IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV----QEMQELKETLNQAETKSKS 1492

Query: 1803 LERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVEN---LKQKMDQQIKEHEHQ 1859
            LE Q++  ++ + + +    N  ++  +L+ EL   ++++++    ++++ QQI E E +
Sbjct: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552

Query: 1860 ----LVLLQCEIQKKSTAKDCTFKPDFEM 1884
                +V  + +I   +  KD   K + E+
Sbjct: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEEL 1581



 Score =  124 bits (312), Expect = 9e-28
 Identities = 307/1618 (18%), Positives = 645/1618 (39%), Gaps = 254/1618 (15%)

Query: 678  EHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQ--- 734
            + Q  +  L+ R E F  +S E Q F      ++EK ++    + QE L +  RE Q   
Sbjct: 31   DQQSEIDGLKGRHEKFKVES-EQQYF------EIEKRLS----HSQERLVNETRECQSLR 79

Query: 735  -EESVYNLYISEVRNIRLRLENCEDRLIR-QIRTPLERDDLH-ESVFRITEQEKLKKELE 791
             E    N  +  +      LE  +DR I  Q +    +++L  E    I   E+L +ELE
Sbjct: 80   LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELE 139

Query: 792  RLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLV 851
             L +D+  +  K +E            T + EL + L  + Q   +S  Y +K       
Sbjct: 140  YLTEDVKRLNEKLKES----------NTTKGELQLKLDEL-QASDVSVKYREKRLEQEKE 188

Query: 852  LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQ 911
            L ++Q      +L +TK  E  A+  +K N       + + +  ++ K++    LE+++ 
Sbjct: 189  LLHSQNTWLNTEL-KTKTDELLALGREKGN------EILELKCNLENKKEEVSRLEEQMN 241

Query: 912  KAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN---VHVQIDNRL------------ 956
              K  ++ + K  ++        KE+   + E++ N    H+++ N              
Sbjct: 242  GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301

Query: 957  ---RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013
               R +E + K LK   +    + D + +VE ++ ++++   E    L  +L     L+S
Sbjct: 302  ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS 361

Query: 1014 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1073
              + K               A + + EL  M+  A   ++                I++ 
Sbjct: 362  ATKRK--------------GAILSEEELAAMSPTAAAVAK----------------IVKP 391

Query: 1074 FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKE--TSEHGAYSDLLQRQKATVL 1131
             M L   Y A V    Q +      L++LE + I +  +    E  A + +L+RQ+    
Sbjct: 392  GMKLTELYNAYVETQDQLL------LEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445

Query: 1132 ENSKLTGKIS-ELERMVAELKKQKSRVEEELPKVREAA---ENELRKQQRNVEDISLQKI 1187
               K    +S +LE+ + E++    R++E+  K  + +   E + R+ +  V+D+S Q  
Sbjct: 446  RAQKAVASLSVKLEQAMKEIQ----RLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIR 501

Query: 1188 RAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTF 1247
                E ++ R     ++R++E +  ++    ++          + ++L+++RN +EE   
Sbjct: 502  VLLMELEEARGN--HVIRDEEVSSADISSSSEV----------ISQHLVSYRN-IEE--- 545

Query: 1248 TRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE-----EELLKLIKQMEKDLAFQK 1302
                L+   +R  ++L +L + + +  +E    +  E     E  L  ++Q+ K    Q 
Sbjct: 546  ----LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601

Query: 1303 QVAEKQLKEKQK----------------------IELEARRKITEIQYTCRENA-LPVCP 1339
            Q+ +  ++++                        + L +  K      T    A +PV  
Sbjct: 602  QLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIE 661

Query: 1340 ITQATSCRAVTGLQQE----HDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLE 1395
             T+A   +A     QE    + K+KAE  K Q ++L     K ++ + +L  +   +  +
Sbjct: 662  STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL----EKLQEQVTDLRSQNTKISTQ 717

Query: 1396 KTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEA 1455
               + ++  +L+D ++     +  L    ++     +   Q +  + + L     K   A
Sbjct: 718  LDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777

Query: 1456 MQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEK 1515
               A +LKK K   +L    L+ ++  L  E     R   +   N+Q +   +     E 
Sbjct: 778  EVRAENLKKEKEMLKLSEVRLSQQRESLLAE----QRGQNLLLTNLQTIQGILERSETET 833

Query: 1516 ELE---RLQICQRKSDHLKEQFEKSHEQ---LLQNIKAEKENNDKIQRLNEELEKSNECA 1569
            +     +++  + +  HLK++ E   EQ   L +N+  +    D  ++L+ E        
Sbjct: 834  KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL--DTKRQLDTETNLHLNTK 891

Query: 1570 EMLKQKVEEL-TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRST 1628
            E+LK   +E+ T + + + + +Q     S+     + + ++  + L  Q    ++Q+   
Sbjct: 892  ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDL 951

Query: 1629 NEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCD---QQNIIIQNT-KKEVRNL 1684
             E L   T   + +Q  +  LEE L K + +  E ++  +   +++   Q   +K++  +
Sbjct: 952  KERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEV 1011

Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744
              E    +++KRR    ++  + Q+ EL   L  VQ+E     ++E +      L  E+ 
Sbjct: 1012 EKEKQELQDDKRRA---IESMEQQLSELKKTLSSVQNE-----VQEALQRASTALSNEQ- 1062

Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKL---CETNIK 1801
                Q+  + +++ +  +E++   E ++     D  +LQ    +  + A +    E   +
Sbjct: 1063 ----QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQ 1118

Query: 1802 ELERQLQQYREQMQQGQHMEANHYQKC------------------QKLEDELIAQKREVE 1843
            + E QL + +   ++ + M  +   KC                  +KL D+++A  +E  
Sbjct: 1119 KAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGV 1178

Query: 1844 N--LKQKMDQQIKEHEHQLVLLQCEIQKKSTAK---------DCTFKPDFEMTVKECQHS 1892
               L   + ++ K  E  L +L+   ++K  A+            ++   E+  +E Q  
Sbjct: 1179 QGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQEL 1238

Query: 1893 GELSSRNTGHLHPTPRS-----PLLRWTQEPQPLEE-----KWQHRVVEQIPKEVQFQPP 1942
             +  +     +  T ++      L++ T+    + E     + +   +EQ  +++Q +  
Sbjct: 1239 QDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVR 1298

Query: 1943 GAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDN 2002
               L+    Q+  +E  S+ S  LQ          +L E +  R +A N     V  Q +
Sbjct: 1299 KLELDILPLQEANAE-LSEKSGMLQAE-------KKLLEEDVKRWKARNQHL--VSQQKD 1348

Query: 2003 ACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFL 2062
                E  K+L+  E+   +   +  E+  LK E   +  +   +         LK+ D  
Sbjct: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAE---IARSNASLTNNQNLIQSLKE-DLN 1404

Query: 2063 KKGLEPETFQNFDGDHACSVRDD-----EFKFQGLRHTVTARQLVEAKLLDMRTIEQL-- 2115
            K   E ET Q         +++      + K  G R+     +L   +   M T  Q   
Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464

Query: 2116 -----RLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVAL 2168
                  + ++ ++E+++TLN+  TK+ S+    +E+ ++ +S      R + ++ V L
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLES-QVENLQKTLSEKETEARNLQEQTVQL 1521



 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 236/1185 (19%), Positives = 471/1185 (39%), Gaps = 186/1185 (15%)

Query: 967  KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ 1026
            K+  D    +D    + E  + + ++   E  K L+   + Q+ LV+E    QS   E +
Sbjct: 27   KFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS---HSQERLVNETRECQSLRLELE 83

Query: 1027 KYAEQYSA-TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
            K   Q  A T K+ EL+    R +    Q +  K        DLI         R +  +
Sbjct: 84   KLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLI-----RTNERLSQEL 138

Query: 1086 TLMTQYIKFAGDSLK-----------------------RLEEEEIKRCKET--SEHGAYS 1120
              +T+ +K   + LK                       +  E+ +++ KE   S++   +
Sbjct: 139  EYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLN 198

Query: 1121 DLLQRQKATVLENSKLTG-KISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNV 1179
              L+ +   +L   +  G +I EL+  +   K++ SR+EE++  ++ + E+     Q++V
Sbjct: 199  TELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH----LQKHV 254

Query: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERV-RQLTIEAEAKRAAVEENLLNF 1238
            ED+ L K++   EAK+ +  +E     +  A  +L  + +    ++EAK   +   +   
Sbjct: 255  EDL-LTKLK---EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEEL 310

Query: 1239 RNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQ----- 1293
               L+E     + ++DHL   + S + +E++  + +  L ++ +N  +LL   K+     
Sbjct: 311  HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAIL 370

Query: 1294 MEKDLAFQKQVAEKQLK---------------------------EKQKI---------EL 1317
             E++LA     A    K                           E ++I         E+
Sbjct: 371  SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430

Query: 1318 EARRKITEIQ---YTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAA 1374
            EA+  I + Q   Y   + A+    +    + + +  LQ++ DK       +Q   L   
Sbjct: 431  EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDK-----ANKQSSVLERD 485

Query: 1375 NRKAEQDMRELTYELNAL--QLEKTSSEEKARLLKDKLDETNNTLRCLKLEL------ER 1426
            NR+ E  +++L+ ++  L  +LE+       R  +    + +++   +   L      E 
Sbjct: 486  NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545

Query: 1427 KDQAEKGYSQQLRELG----RQLNQTTG--------KAEEAMQEASDLKKIKRNYQLELE 1474
              Q  +     LRELG    R+  +TT         K E A+ E   L+K +++    ++
Sbjct: 546  LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605

Query: 1475 SLNHEKGKLQREVDRIT------RAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528
            S+  ++   +  + + T       A ++ + ++     +  + +       + + +    
Sbjct: 606  SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665

Query: 1529 HLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKL 1588
               +   K  +++ +N K EK  N+KIQ  NE+LEK       L+++V +L  QN  TK+
Sbjct: 666  IEAKAALKQLQEIFENYKKEKAENEKIQ--NEQLEK-------LQEQVTDLRSQN--TKI 714

Query: 1589 MMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKC 1648
              Q   A             +R E L+   +G++ ++ S +E   K T T Q  ++ I  
Sbjct: 715  STQLDFA------------SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762

Query: 1649 LEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLN-AELNASKEEKRRGEQKVQLQQA 1707
            + +DL  +        +K     +  +N KKE   L  +E+  S++     E  +  Q+ 
Sbjct: 763  MTQDLRGA-------NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR----ESLLAEQRG 811

Query: 1708 QVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVI 1767
            Q   L N L+ +Q       +E   T  K  L   +  K +      +KK+E  +E +  
Sbjct: 812  QNLLLTN-LQTIQG-----ILERSETETKQRL-SSQIEKLEHEISHLKKKLENEVEQRHT 864

Query: 1768 TENDISGIRLDFV-SLQQENS---RAQENAKLCETNIKELERQLQQYREQMQQGQHMEAN 1823
               ++    LD    L  E +     +E  K  +  I  L++ L     Q+         
Sbjct: 865  LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTG 924

Query: 1824 HYQKCQKLE-DELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882
              Q   K + D+L++Q R+ E     + +++K     +   Q  +    T+ + +   + 
Sbjct: 925  KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980

Query: 1883 EMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPP 1942
            ++T +E + + E+  + +          L+   +E Q L++  + R +E + +++     
Sbjct: 981  QVT-EEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDD-KRRAIESMEQQL----- 1033

Query: 1943 GAPLEKEKS--QQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQ 2000
             + L+K  S  Q    E   + ST L    +E        E  KI  +A N     +   
Sbjct: 1034 -SELKKTLSSVQNEVQEALQRASTALS---NEQQARRDCQEQAKIAVEAQNKYERELML- 1088

Query: 2001 DNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEW 2045
             +A ++E ++     +++K      H E TT K E   +     W
Sbjct: 1089 -HAADVEALQAAKE-QVSKMASVRQHLEETTQKAESQLLECKASW 1131



 Score = 81.6 bits (200), Expect = 9e-15
 Identities = 267/1439 (18%), Positives = 562/1439 (39%), Gaps = 167/1439 (11%)

Query: 110  ECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQT 169
            E    ++ H+++V+     K     ++++++ +L  E+    +  S+   KG IL+ E+ 
Sbjct: 319  EANKAIQDHLLEVE---QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEEL 375

Query: 170  KLM---ISGITQSLNSGFAQT-LHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTS-RLTPS 224
              M    + + + +  G   T L+ +      Q L   L +  +   L   +        
Sbjct: 376  AAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAP 435

Query: 225  VTPAYTPGFPSG--LVPNFSSGVEPNSLQTLKLMQ-IRKPLLKSSLLDQNLTEEEINMKF 281
            +       +      V + S  +E    +  +L +   K   +SS+L+++    EI +K 
Sbjct: 436  ILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKD 495

Query: 282  VQD----LLNWVDEMQ---VQLDRTEWGSDLPSVESHLENHKNVHRAIEEFES------- 327
            +      LL  ++E +   V  D     +D+ S    +  H   +R IEE +        
Sbjct: 496  LSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLV 555

Query: 328  SLKE--------------AKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 373
            +L+E              +KI+E+Q+     LT  E+L +      +L+++   Q    D
Sbjct: 556  ALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR---D 612

Query: 374  TLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL----MRELDQKEENI 429
                 +S+ T   I L+    ++V+   + +  + ++     A +      E  + +  +
Sbjct: 613  MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL 672

Query: 430  KSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAK 489
            K +QEI E    E              +Q Q + +      +   +   +  +E   D  
Sbjct: 673  KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732

Query: 490  EATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ---ESMEEKEELLQYKSTIANLMGKAK 546
            E   Y R +    +R      +++  K E ++    + +    E L      A  + K K
Sbjct: 733  EG--YRREITSLHERNQKL--TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788

Query: 547  TIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEA 606
             +++L         ++ +  +     + + +T  +  + +L  +    K ++ S      
Sbjct: 789  EMLKLSEVRLSQQRESLLAEQR---GQNLLLTNLQTIQGILERSETETKQRLSS------ 839

Query: 607  MVPSVCFTVPPPNKEAVDLANRIEQQY---QNVLTLWHESHINMKSVVSWHYLINEIDRI 663
             +  +   +    K+   L N +EQ++   +N+     ++   + +  + H    E+ + 
Sbjct: 840  QIEKLEHEISHLKKK---LENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896

Query: 664  RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 723
                +A++K  L     QV S    R       ++E      S + Q E++VN  K+   
Sbjct: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE--- 953

Query: 724  ELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQ 783
             L  S    EQ       Y + V ++   L N E ++  ++R  +E   L ES    T+ 
Sbjct: 954  RLKTSTSNVEQ-------YQAMVTSLEESL-NKEKQVTEEVRKNIEVR-LKESAEFQTQL 1004

Query: 784  EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843
            EK   E+E+ K +L     +  E   Q  +      L+  L+ V   + +    +ST   
Sbjct: 1005 EKKLMEVEKEKQELQDDKRRAIESMEQQLSE-----LKKTLSSVQNEVQEALQRAST--- 1056

Query: 844  KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIA--DKNNIENL-------ISTLKQWRS 894
                    L N Q A         + C+E+A IA   +N  E         +  L+  + 
Sbjct: 1057 -------ALSNEQQAR--------RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKE 1101

Query: 895  EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954
            +V +   V   LE+  QKA++   E   +++ER+      K++  + V R +++  Q  N
Sbjct: 1102 QVSKMASVRQHLEETTQKAESQLLECKASWEERERML---KDEVSKCVCRCEDLEKQ--N 1156

Query: 955  RLRDLEGIGKSLKYYRDTYHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQKMLV 1012
            RL              D    L D +     E  Q  +  +  E  K+    L   + + 
Sbjct: 1157 RL------------LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204

Query: 1013 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1072
             E E+ +++ +  Q  + +Y   V+  E      R + + Q     +R ++Q +A  + Q
Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLE------RELQELQDSLNAEREKVQVTAKTMAQ 1258

Query: 1073 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLE 1132
                ++   T  V + T   K   +  +RLE++   +  +        D+L  Q+A   E
Sbjct: 1259 HEELMKKTETMNVVMETN--KMLREEKERLEQD--LQQMQAKVRKLELDILPLQEANA-E 1313

Query: 1133 NSKLTGKISELERMVAE-LKKQKSRVEEELPKVREAAENELRK--QQRNVEDISLQKI-- 1187
             S+ +G +   ++++ E +K+ K+R +  + + ++    E RK   ++ V    +Q++  
Sbjct: 1314 LSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTE 1373

Query: 1188 ---RAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEE 1244
               R ++E  +    L       ++ + +L +VR    E E  +  ++  +++ + +++ 
Sbjct: 1374 EIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT---EKETIQKDLDAKIIDIQEKVKT 1430

Query: 1245 NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQME--KDLAFQK 1302
             T  ++      +R      +L+ Q++K+ME   +   + +E    +++M+  K+   Q 
Sbjct: 1431 ITQVKKIG----RRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486

Query: 1303 QVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAE 1362
            +   K L+     ++E  +K    + T   N        Q+   R    LQ    ++  E
Sbjct: 1487 ETKSKSLES----QVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE--E 1540

Query: 1363 ELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKL 1422
            +L+QQ+ E     RKA    +     L  ++ + T   E+ +     LD+  + L     
Sbjct: 1541 QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT 1600

Query: 1423 ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKG 1481
             L  K Q E   S+  REL     +   + +E  + ++ + + +R   L+    + E+G
Sbjct: 1601 AL--KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  158 bits (400), Expect = 6e-38
 Identities = 303/1548 (19%), Positives = 643/1548 (41%), Gaps = 210/1548 (13%)

Query: 408  IARKKDYHAELMRELDQKEEN---------IKSVQEIAEQLLLENHPARLTIEAYRAAMQ 458
            I + K    EL +E+++             IK++ E  + LLLE        E  +  + 
Sbjct: 41   IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEK------AETEQQCLS 94

Query: 459  TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCDRSSSIH 515
             +   I    +  +   K   A+ E           + NLK+   A++ KYS D+++   
Sbjct: 95   LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQK 154

Query: 516  KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI 575
            +LE+ +   +E  E+L    ++  N+    + I +++P   +  L     + A  D ++ 
Sbjct: 155  QLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKE 214

Query: 576  EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQN 635
             +T  ++   + AN+ H    K I+    E +            +E  +L  +IE   + 
Sbjct: 215  TVTQLQN--IIEANSQHYQ--KNINSLQEELLQLKAIH-----QEEVKELMCQIEASAKE 265

Query: 636  VLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLE 695
                 HE+ IN          +NE+         + +  +  +++  L NL+    +  +
Sbjct: 266  -----HEAEINK---------LNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQ 311

Query: 696  DSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE- 754
            D+Q   +    + T +E+ VN   ++ ++ LK     E + S+    ++ + N++L+LE 
Sbjct: 312  DNQICSILL-QENTFVEQVVNEKVKHLEDTLKEL---ESQHSILKDEVTYMNNLKLKLEM 367

Query: 755  ---NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKE----LERLKDDLGTITNKCEEF 807
               + +D          ER+DL    F+I E    K+E    +E+LK +L  +       
Sbjct: 368  DAQHIKDEFFH------EREDLE---FKINELLLAKEEQGCVIEKLKSELAGLN------ 412

Query: 808  FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYET 867
                         +     V Q+  +V S+   +  ++  +N    +    E L  ++E 
Sbjct: 413  -------------KQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEI 459

Query: 868  KLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKER 927
            +  +E+         ENL    ++     +  R++   L+ EL ++     + F++ K+ 
Sbjct: 460  QGLKEQC--------ENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQ- 510

Query: 928  DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987
                    ++A  + E  Q +      +   LE + + L+   +      + + ++E T 
Sbjct: 511  --------QQASDVHELQQKLRTAFTEKDALLETVNR-LQGENEKLLSQQELVPELENTI 561

Query: 988  RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1047
            + +Q    E +      L+Q+  ++ E+E    K++   +  + +   +K+   +   + 
Sbjct: 562  KNLQ----EKNGVYLLSLSQRDTMLKELE---GKINSLTEEKDDFINKLKNSHEEMDNFH 614

Query: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE--E 1105
               + +++  ++   +    +  IQ   +L  +   L   + + +K    + ++LE+   
Sbjct: 615  KKCEREERLILE---LGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 671

Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRV--EEELPK 1163
            ++K   E  E      L    K+   EN+KL+ +  +L R +     QK  V  +E + +
Sbjct: 672  QMKVLSEDKE-----VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQ 726

Query: 1164 VREAAENELRKQ---QRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL 1220
            + +  +  + +Q    + +E+  +QK+  +++   + +E+ + V E ++ E+++  V Q 
Sbjct: 727  LEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSE-DSEEKDVVNVLQA 785

Query: 1221 TIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLK-RKDLSLNDLEQQKNKLMEELRR 1279
              E+ AK   + E   N   Q +E       LE  +K  ++ S+   E+ K+ L +  + 
Sbjct: 786  VGESLAK---INEEKCNLAFQRDEKVL---ELEKEIKCLQEESVVQCEELKSLLRDYEQE 839

Query: 1280 K---RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRE---- 1332
            K   R   EE+    + ++ DL   K   EK   E Q + ++    + E+  TC +    
Sbjct: 840  KVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQ----VEEVSQTCSKSEIH 895

Query: 1333 NALPVCPITQATSCRAVTGLQQEHDKQKAEE---LKQQVDELTAANRKAEQDMRELTYEL 1389
            N    C I +  + + +  L+Q+  + +  E   LK  + +  +        ++EL  ++
Sbjct: 896  NEKEKCFIKEHENLKPL--LEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKI 953

Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449
                LEK   E++ ++ K KL          K EL+   +  +   ++L  L  + +Q +
Sbjct: 954  E--NLEKECKEKEEKINKIKLVAVK-----AKKELDSSRKETQTVKEELESLRSEKDQLS 1006

Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEK---GKLQREVDRITRAHAVAEKNIQHLNS 1506
                + +Q A   K +   Y+ + E L+ EK      +  ++ +TR    +    + +NS
Sbjct: 1007 ASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINS 1066

Query: 1507 QIHSFRDEKELERLQICQRKSDHLKEQ-FEKSHEQLLQNIKAEKENNDKIQRLNEELEKS 1565
                  +E  L R++  Q  +  L+ Q  E    + + + + E E   K Q++ E     
Sbjct: 1067 D-----NEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTV 1121

Query: 1566 NECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQL 1625
            NE        +EEL  Q  + K  +Q+   E E   L K+  QQ    + ++   ++  +
Sbjct: 1122 NE--------LEELQVQLQKEKKQLQKTMQELE---LVKKDAQQ-TTLMNMEIADYERLM 1169

Query: 1626 RSTNEHLHKQTKTEQDFQRKIK-------CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK 1678
            +  N+ L  +    +D +++IK        L+E++   Q+ V ++++K  +   ++  TK
Sbjct: 1170 KELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTK 1229

Query: 1679 KEVRNLNAE------LNAS-KEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQ 1731
            KE+ +          L AS K E    +Q+V++ + Q+ E+ +   K+ +  HLKT  EQ
Sbjct: 1230 KELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHE--HLKTSAEQ 1287

Query: 1732 MTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQEN-SRAQ 1790
               R +  +Q+     + +A +   +  K  ++ V +E +   +R+  V  QQ+N S +Q
Sbjct: 1288 -HQRTLSAYQQ-----RVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ 1341

Query: 1791 ENAKLCETNIKELERQLQQYREQMQQGQH---MEANHYQKCQKLEDELIAQKREVENLKQ 1847
               +  +   + LE  + Q + ++Q  Q+   +  +  Q  Q   D L+ +         
Sbjct: 1342 AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLER-------HN 1394

Query: 1848 KMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGEL 1895
            KM Q+    E +L    C IQ    +++   K +   TV +     E+
Sbjct: 1395 KMLQETVSKEAELREKLCSIQ----SENMMMKSEHTQTVSQLTSQNEV 1438



 Score =  153 bits (386), Expect = 2e-36
 Identities = 280/1448 (19%), Positives = 614/1448 (42%), Gaps = 201/1448 (13%)

Query: 680  QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739
            +Q + +  ++  D  ++ ++S +    +I  L+ E+   +  Y E   + +++ +E    
Sbjct: 103  KQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNT 162

Query: 740  NLYISEVRNIRLRLENCEDRLIRQIRTPLE--RDDLHESVFRITEQEKLKKELERLKDDL 797
             L +SE    +L+ +N  +  +++++  +E  R    E +  +  Q++L    +  K+ +
Sbjct: 163  QLELSE----QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYL--QKQLDATTDEKKETV 216

Query: 798  GTITNKCEEFFSQAAASSSVPTLRSEL--------NVVLQNMNQVYSMSSTY---IDKLK 846
              + N  E   +      ++ +L+ EL          V + M Q+ + +  +   I+KL 
Sbjct: 217  TQLQNIIEA--NSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLN 274

Query: 847  TV--NLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDE--KRQV 902
             +  NLV +   + + + K YE +L       ++ N    + S L Q  + V++    +V
Sbjct: 275  ELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334

Query: 903  FHALEDELQK-------------------------AKAISDEMFKTYKERDLDFDWHKEK 937
             H LED L++                         A+ I DE F  ++  DL+F     K
Sbjct: 335  KH-LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFF--HEREDLEF-----K 386

Query: 938  ADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPEN 997
             ++L+   +     I+    +L G+ K   Y  + ++      ++V++ + + Q+   E 
Sbjct: 387  INELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN------REVQSLKEQHQKEISEL 440

Query: 998  SKTLATQLNQQKM-LVSEIEMKQSKMDECQKYAEQYSATVKDYE--------LQTMTYRA 1048
            ++T  +   ++K+ L+ EI   Q   ++C+   ++    + +YE        LQT    +
Sbjct: 441  NETFLSDSEKEKLTLMFEI---QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGES 497

Query: 1049 MVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEI- 1107
                 Q+    +++  S    + Q+   LRT +T    L+    +  G++ K L ++E+ 
Sbjct: 498  AGKISQEFESMKQQQASDVHELQQK---LRTAFTEKDALLETVNRLQGENEKLLSQQELV 554

Query: 1108 ----KRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPK 1163
                   K   E      L   Q+ T+L+  +L GKI+ L     +   +     EE+  
Sbjct: 555  PELENTIKNLQEKNGVYLLSLSQRDTMLK--ELEGKINSLTEEKDDFINKLKNSHEEMDN 612

Query: 1164 VREAAENELR---KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVR-Q 1219
              +  E E R   +  + VE         E +  +    LE  ++EK+  +++LE++  Q
Sbjct: 613  FHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ 672

Query: 1220 LTIEAEAKR--AAVEENLLNFRNQLE-ENTFTRRTLEDHLKRK-DLSLNDLEQQKNKLME 1275
            + + +E K   +A  ++L    N+L  E     R LE  L +K D+ L +   Q  K ++
Sbjct: 673  MKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQ 732

Query: 1276 ELRRKRDNEEELLK---------------LIKQM---------EKDLAFQKQVAEKQL-- 1309
             +  ++DN  +LL+                +K+M         EKD+    Q   + L  
Sbjct: 733  LMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792

Query: 1310 --KEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQ 1367
              +EK  +  +   K+ E+     E  +          C  +  L ++++++K   L+++
Sbjct: 793  INEEKCNLAFQRDEKVLEL-----EKEIKCLQEESVVQCEELKSLLRDYEQEKVL-LRKE 846

Query: 1368 VDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELER- 1426
            ++E+ +     + D+ E+    NA   EKT  E +  L++  ++E + T  C K E+   
Sbjct: 847  LEEIQSEKEALQSDLLEMK---NAN--EKTRLENQNLLIQ--VEEVSQT--CSKSEIHNE 897

Query: 1427 KDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK---------RNYQLELESLN 1477
            K++      + L+ L  Q      +AE  + + S  K            +  + ++E+L 
Sbjct: 898  KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957

Query: 1478 HEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKS 1537
             E  + + ++++I      A+K +     +  + ++E E  R +         K+Q   S
Sbjct: 958  KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE---------KDQLSAS 1008

Query: 1538 HEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597
               L+Q  ++ K    + ++ +E+L+   E A   + ++E+LTRQ   + L  + I +++
Sbjct: 1009 MRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDN 1068

Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657
            E+++   +T+Q   + L++Q      +++     + K+ + E+  Q+     E+ + +  
Sbjct: 1069 EDLLARIETLQSNAKLLEVQI----LEVQRAKAMVDKELEAEK-LQK-----EQKIKEHA 1118

Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRG---EQKVQLQQAQVQELNN 1714
              V+E     ++  + +Q  KK+++    EL   K++ ++      ++   +  ++ELN 
Sbjct: 1119 TTVNEL----EELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQ 1174

Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISG 1774
            +L    +++     E ++  +K    QEE    + S +++ +K  K+ +  V T+ +++ 
Sbjct: 1175 KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234

Query: 1775 IR-------LDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQM----QQGQHMEAN 1823
             +       +   SL+ E   +Q+  ++ +  + E+  +  +  E +    +Q Q   + 
Sbjct: 1235 SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSA 1294

Query: 1824 HYQKCQKLEDELIAQKREVENLKQKMDQ-QIKEHEHQLVLLQCEIQKKSTAKDCTFKPD- 1881
            + Q+   L++E  A K E   +  + +  +++ H    VL Q + +  S A+    K + 
Sbjct: 1295 YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHN---VLKQQKNKSMSQAETEGAKQER 1351

Query: 1882 --FEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQF 1939
               EM + + +   + S  N         S L     E   L E+    + E + KE + 
Sbjct: 1352 EHLEMLIDQLKIKLQDSQNNL----QINVSELQTLQSEHDTLLERHNKMLQETVSKEAEL 1407

Query: 1940 QPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRY 1999
            +     ++ E +    SE+   T T  Q+T    N + R S  +++R     + +     
Sbjct: 1408 REKLCSIQSE-NMMMKSEH---TQTVSQLT--SQNEVLRNSFRDQVRHLQEEHRKTVETL 1461

Query: 2000 QDNACEME 2007
            Q    +ME
Sbjct: 1462 QQQLSKME 1469



 Score =  116 bits (291), Expect = 3e-25
 Identities = 206/1034 (19%), Positives = 442/1034 (42%), Gaps = 146/1034 (14%)

Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVE 1180
            DL++  K  ++   K   + +ELE+ + EL+ +   V E    + +A    L        
Sbjct: 29   DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKP--VTEGTGDIIKALTERLDALLLEKA 86

Query: 1181 DISLQKIRAESEAKQYRRELETIVREKEAAERELER--------VRQLTIEAEAKRAAVE 1232
            +   Q +  + E  + ++E+E  V +   A +ELE+        +  L  E  A R+   
Sbjct: 87   ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146

Query: 1233 ENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDN-EEELLKLI 1291
            E+  N + QLEE   T+  L + LK +    N+ E    KL EE+ + R   EE++L L 
Sbjct: 147  EDKANLQKQLEEAMNTQLELSEQLKFQ----NNSEDNVKKLQEEIEKIRPGFEEQILYLQ 202

Query: 1292 KQME------KDLAFQKQ----------------VAEKQLKEKQKIELEARRKITEIQYT 1329
            KQ++      K+   Q Q                + E+ L+ K   + E +  + +I+ +
Sbjct: 203  KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262

Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQD-------M 1382
             +E+   +  + +            E + QK  E   +++ L  A   A QD       +
Sbjct: 263  AKEHEAEINKLNELKENLVKQCEASEKNIQKKYEC--ELENLRKATSNANQDNQICSILL 320

Query: 1383 RELTYELNAL-----QLEKTSSEEKAR--LLKDKLDETNNTLRCLKLELERKDQAEKG-Y 1434
            +E T+    +      LE T  E +++  +LKD++   NN    LKL+LE   Q  K  +
Sbjct: 321  QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN----LKLKLEMDAQHIKDEF 376

Query: 1435 SQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLN----HEKGKLQREVDRI 1490
              +  +L  ++N+     EE   +   ++K+K     EL  LN    +   +  REV  +
Sbjct: 377  FHEREDLEFKINELLLAKEE---QGCVIEKLKS----ELAGLNKQFCYTVEQHNREVQSL 429

Query: 1491 TRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE---KSHEQLLQNIKA 1547
               H   +K I  LN    +F  + E E+L +   +   LKEQ E   +  ++ + N ++
Sbjct: 430  KEQH---QKEISELN---ETFLSDSEKEKLTL-MFEIQGLKEQCENLQQEKQEAILNYES 482

Query: 1548 EKENNDKIQ--------RLNEELE--KSNECAEM--LKQKVEELTRQNNETKLMMQRIQA 1595
             +E  + +Q        ++++E E  K  + +++  L+QK+     + +     + R+Q 
Sbjct: 483  LREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG 542

Query: 1596 ESENIVLEKQTIQQRCEALK----------IQADGFKDQLRSTNEHLHKQTKTEQDFQRK 1645
            E+E ++ +++ + +    +K          +        L+     ++  T+ + DF  K
Sbjct: 543  ENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINK 602

Query: 1646 IKCLEEDL-------AKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRG 1698
            +K   E++        + + L+ E  +K +Q        +++V  L   L  + +EK + 
Sbjct: 603  LKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQN 662

Query: 1699 EQKVQLQQAQVQELNN-------RLKKVQDELHLKTIEEQMTHRKMVLF--QEESGKFKQ 1749
            +QK++    Q++ L+         +K + +E +  + E++   R + +F  Q+E    K+
Sbjct: 663  DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKE 722

Query: 1750 SAEEFRKKMEKLMESK----VITENDISGIRLDFVSLQQENSRAQENAKLCE-TNIKELE 1804
               +  KK++ ++E +     + EN+   ++  FV  Q      +  +++ E +  K++ 
Sbjct: 723  HITQLEKKLQLMVEEQDNLNKLLENE--QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780

Query: 1805 RQLQQYREQMQQGQHMEAN----HYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860
              LQ   E + +    + N      +K  +LE E+   + E     +++   ++++E + 
Sbjct: 781  NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840

Query: 1861 VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP 1920
            VLL+ E+++  + K+       EM  K       L ++N           L++  +  Q 
Sbjct: 841  VLLRKELEEIQSEKEALQSDLLEM--KNANEKTRLENQNL----------LIQVEEVSQT 888

Query: 1921 LEEKWQHRVVEQ--IPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITR 1978
              +   H   E+  I +    +P    LE+++ +   +E      +  +    + +P++ 
Sbjct: 889  CSKSEIHNEKEKCFIKEHENLKP---LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSS 945

Query: 1979 LSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNP 2038
            + E+E+ + + L         + N  ++  VK    L+ ++ +   +  E+ +L+ EK+ 
Sbjct: 946  VKELEE-KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQ 1004

Query: 2039 VPSAEEWMLEGCRA 2052
            + ++   +++G  +
Sbjct: 1005 LSASMRDLIQGAES 1018



 Score = 32.3 bits (72), Expect = 6.4
 Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 9/97 (9%)

Query: 289  VDEMQVQLDRTEWG-----SDLPSVESH----LENHKNVHRAIEEFESSLKEAKISEIQM 339
            +D+++++L  ++       S+L +++S     LE H  + +     E+ L+E   S    
Sbjct: 1358 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1417

Query: 340  TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLH 376
               +K  + + + +L SQ   L N+ R+Q RHL   H
Sbjct: 1418 NMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEH 1454


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  155 bits (391), Expect = 7e-37
 Identities = 208/1036 (20%), Positives = 444/1036 (42%), Gaps = 102/1036 (9%)

Query: 895  EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954
            +V  + +   A EDELQK K                    ++KA+  ++  +  H Q+  
Sbjct: 846  QVTRQEEEMQAKEDELQKTKE------------------RQQKAENELKELEQKHSQLTE 887

Query: 955  RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
                L+   + L+   + Y   ++   ++   +++++E   E    L  + ++ + L +E
Sbjct: 888  EKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 944

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV----KRRRMQSSADLI 1070
             +    +M + ++  E+  A  +  +L+ +T  A +   +   +    +  ++     L+
Sbjct: 945  RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004

Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130
             +   DL T             K        + E E++  KE         L ++ +   
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-- 1062

Query: 1131 LENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-A 1189
             + S    +I++L+  +AELK Q ++ EEEL       ++E+ ++       +L+KIR  
Sbjct: 1063 -DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-----ALKKIREL 1116

Query: 1190 ESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE------ 1243
            E      + +L++   E+ A  +  ++ R L  E EA +  +E+ L +   Q E      
Sbjct: 1117 EGHISDLQEDLDS---ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173

Query: 1244 -ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEEL-------RRKRDNEEELLKLIKQME 1295
             E T  ++ L++  +  +  + ++ Q+  + +EEL       +R + N ++  + +++  
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233

Query: 1296 KDLAFQKQV--AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ-----ATSCRA 1348
             DLA + +V    KQ  E +K +LEA  ++ E+Q  C +       +            +
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEA--QVQELQSKCSDGERARAELNDKVHKLQNEVES 1291

Query: 1349 VTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408
            VTG+  E +  KA +L + V  L++  +  ++ ++E T +   +  +    EE+   L+D
Sbjct: 1292 VTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350

Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRN 1468
            +LDE          E+E K   E+     +  L  QL+ +  K ++       L++ K+ 
Sbjct: 1351 QLDE----------EMEAKQNLER----HISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528
            +Q E+E+L  +  +     D++ +     ++ +  L   + + R  + +  L+  QRK D
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFD 1454

Query: 1529 H-LKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587
              L E+   S +   +  +AE E  +K     + L  +    E L+ K EEL R N   K
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARALEEALEAK-EELERTNKMLK 1510

Query: 1588 LMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIK 1647
              M+ + +  +++      +++   AL+ Q +  K QL    E L  + +  +D + +++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLE 1566

Query: 1648 CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQA 1707
                     Q L  +F++  D Q    QN +K  R L  +L+  + E     ++  L  A
Sbjct: 1567 ------VNMQALKGQFER--DLQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAA 1617

Query: 1708 QVQELNNRLK--KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESK 1765
              ++L   LK  ++Q +  +K  EE +  +++   Q +   F++  E+ R   +++  + 
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825
               E     +  D + LQ++ + A+   K  +   +EL  +L          Q  +    
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 1826 QKCQKLEDELIAQKREVENLK---QKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882
             +  +LE+EL  ++  +E +    +K  QQ ++  ++L   +   QK  +A+    + + 
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795

Query: 1883 EMTVKECQHSGELSSR 1898
            E+  K  +  G + S+
Sbjct: 1796 ELRSKLHEMEGAVKSK 1811



 Score =  146 bits (368), Expect = 3e-34
 Identities = 214/1136 (18%), Positives = 488/1136 (42%), Gaps = 124/1136 (10%)

Query: 769  ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF-SQAAASSSVPTLRSELNVV 827
            + D+L ++  R  + E   KELE+    L    N  +E   ++    +    +R  L   
Sbjct: 857  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916

Query: 828  LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 887
             Q + ++       +++ +     L+  +   A   L   +  EEE     K  +E + +
Sbjct: 917  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 888  TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 947
              K    +++++  V     ++L K + + +E          + +   +   +L  + ++
Sbjct: 977  EAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034

Query: 948  VHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006
            +  +++ RL+  E   + L K  R       D+ +Q+   Q +I E        L  QL 
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLA 1086

Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066
            +++    E++   +++D+  + A++ +A  K  EL+        D   +   + +  +  
Sbjct: 1087 KKE---EELQAALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 1067 ADLIIQEFMDLRTRYT-ALVTLMTQYIKFAGDSLKRLEEEEIKRCK-----ETSEHGAYS 1120
             DL  +E   L+T     L +  TQ        L+   E+E+   K     ET  H A  
Sbjct: 1142 RDLG-EELEALKTELEDTLDSTATQ------QELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP------KVREAAENELRK 1174
              ++++ A  +E  +LT ++ + +R  A L K K  +E+E        +V   A+ E+  
Sbjct: 1195 QEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 1175 QQRNVEDISLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEE 1233
            +++ +E   +Q+++++ S+ ++ R EL   V +    + E+E V  +  EAE K   + +
Sbjct: 1253 KKKKLE-AQVQELQSKCSDGERARAELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAK 1308

Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRK---DLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290
            ++ +  +QL++   T+  L++  ++K      L  LE+++N L ++L  + + ++ L + 
Sbjct: 1309 DVASLSSQLQD---TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVT 1350
            I  +   L+  K+  +      + +E   +R   EI                        
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI------------------------ 1401

Query: 1351 GLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKL 1410
                E+  Q+ EE     D+L     + +Q++ +L  +L+  +   ++ E+K R     L
Sbjct: 1402 ----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470
             E  N       E +R +   +    +   L R L       EEA++   +L++  +  +
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARAL-------EEALEAKEELERTNKMLK 1510

Query: 1471 LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELE-----RLQICQR 1525
             E+E L   K  + + V  + ++    E  ++ + +Q+    DE +       RL++  +
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL-EKSNECAEMLKQK-VEELTRQN 1583
                LK QFE+  +        +++N +K ++L  +L E   E  +  KQ+ +    ++ 
Sbjct: 1571 A---LKGQFERDLQA------RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621

Query: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643
             E  L    +QA+S   +  ++   ++   L+ Q   F+ +L        +   T ++ +
Sbjct: 1622 LEGDLKDLELQADSA--IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679

Query: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703
            +K K LE DL + Q  ++  ++   Q ++  +   +E+ +  +  NA ++EKRR E ++ 
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL-- 1761
              + +++E    ++ + D +   T + +    ++   +  + K + + ++  ++ ++L  
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799

Query: 1762 ----MESKVITE--NDISGIRLDFVSLQQ-------ENSRAQENAKLCETNIKEL----- 1803
                ME  V ++  + I+ +      L++       E   A ++ K  +  +KE+     
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859

Query: 1804 -ERQL-QQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             ER++ +QY+EQ ++G        ++ ++ E+E          L++++D+  + +E
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915



 Score =  140 bits (353), Expect = 2e-32
 Identities = 225/1172 (19%), Positives = 485/1172 (41%), Gaps = 190/1172 (16%)

Query: 691  EDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIR 750
            ED L+ ++E Q  + +++ +LE++ +   Q  +E     E+ + E  +Y    +E   +R
Sbjct: 858  EDELQKTKERQQKAENELKELEQKHS---QLTEEKNLLQEQLQAETELY----AEAEEMR 910

Query: 751  LRLENCEDRLIRQIRTPLERDDLHESVFRITEQE----KLKKELERLKDDLGTITNKCEE 806
            +RL   +  L          + LHE   R+ E+E    +L+ E +++   +  +  + EE
Sbjct: 911  VRLAAKKQEL---------EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 807  F--------FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858
                       +  A + +  L  E+ +V+ + N                N + K  +  
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEI-LVMDDQN----------------NKLSKERKLL 1004

Query: 859  EALVKLYETKLCEEEAVIAD----KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAK 914
            E  +    T L EEE    +    KN  E++IS L+    + ++ RQ    L+ +L+   
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064

Query: 915  AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974
            +                D+H++ AD L  +   + +Q+  +  +L+              
Sbjct: 1065 S----------------DFHEQIAD-LQAQIAELKMQLAKKEEELQA----------ALA 1097

Query: 975  PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1034
             LDD I Q     +KI+E +   S  L   L+ ++   ++ E ++  + E     E    
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGE---ELEALKT 1153

Query: 1035 TVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093
             ++D    T T + +    +Q+  V ++ +         +  ++R ++   V  +T+ + 
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1212

Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LENSKLTGKISELERMVAELKK 1152
                       E+ KR K           L + K T+  EN+ L G++  L +   E++ 
Sbjct: 1213 -----------EQFKRAKAN---------LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 1153 QKSRVEEELPKVR------EAAENELR----KQQRNVEDISLQKIRAESEAKQYRRELET 1202
            +K ++E ++ +++      E A  EL     K Q  VE ++     AE +A +  +++ +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262
            +  + +  +  L+   +  +    K   +EE   + ++QL+E    ++ LE H+   ++ 
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 1263 LND------------------------------------------LEQQKNKLMEELRR- 1279
            L+D                                          LE+ KN+L +EL   
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432

Query: 1280 --KRDNEEELLKLIKQMEKD----LAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR-- 1331
                DN+ +L+  +++ ++     LA +K ++ K   E+ + E EAR K T+     R  
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492

Query: 1332 ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNA 1391
            E AL      + T+   +   + E      +++ + V EL  + R  E  M E+  +L  
Sbjct: 1493 EEALEAKEELERTN--KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 1392 LQLEKTSSEE-KARLLKDKLDETNNTLRCLKLELERKDQA-EKGYSQQLRELGRQLNQTT 1449
            L+ E  ++E+ K RL      E N  ++ LK + ER  QA ++   ++ R+L RQL++  
Sbjct: 1551 LEDELQATEDAKLRL------EVN--MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602

Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIH 1509
             + E+  ++ +     K+  + +L+ L       + + D   +    A K ++ L +Q+ 
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDL-------ELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 1510 SFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE-KSNEC 1568
             F  ++ELE  +  + +     ++ EK  + L  ++   +E+    +R  ++ + +  E 
Sbjct: 1656 DF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713

Query: 1569 AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK---QTIQQRCEALKIQADGFKDQL 1625
            AE L   +       +E + +  RI    E +  E+   + +  R      QA+   ++L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV-SEFKQKCDQQNIIIQNTKKEVRNL 1684
             +      K     Q  +R+ K L   L + +  V S+FK         I   +++V   
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833

Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744
              E  A+ +  ++ ++K++    QV++     ++ +++        +   R++   +EES
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893

Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIR 1776
             +   +  + ++++++  ES      +++ ++
Sbjct: 1894 QRINANRRKLQRELDEATESNEAMGREVNALK 1925



 Score =  129 bits (325), Expect = 3e-29
 Identities = 225/1107 (20%), Positives = 446/1107 (40%), Gaps = 149/1107 (13%)

Query: 627  NRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNL 686
            N +++  Q    L  E ++  + + +   L  E + +R    A  +     E +++L  +
Sbjct: 873  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEM 927

Query: 687  QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEV 746
            ++R E+  E+ +  Q+       Q E+     K+  Q++L   E+ E+EE+       E 
Sbjct: 928  EARLEE--EEDRGQQL-------QAER-----KKMAQQMLDLEEQLEEEEAARQKLQLEK 973

Query: 747  RNIRLRLENCEDRLI----RQIRTPLERDDLHESVFRIT----EQEKLKKELERLKDDLG 798
                 +++  ED ++    +  +   ER  L E +  +T    E+E+  K L +LK+   
Sbjct: 974  VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033

Query: 799  TITNKCEEFFSQAAAS-SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 857
            ++ ++ E    +   S   +  L+ +L     + ++  +     I +LK + L  K  + 
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-MQLAKKEEEL 1092

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA-I 916
              AL +L +         IA KNN    I  L+   S++ E      A  ++ +K K  +
Sbjct: 1093 QAALARLDDE--------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 917  SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHV---QIDNRLRDLEGIGKSLKY-YRDT 972
             +E+     E +   D    + +   +R Q V V    +D   R  E   + ++  +   
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 973  YHPLDDWIQQVETTQRKIQENQPENSKT---LATQL-----------NQQKMLVSEIEMK 1018
               L + ++Q +  +  + +N+    K    LA +L           +++K L ++++  
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264

Query: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL- 1077
            QSK  + ++   + +  V   + +  +   M++  +   +K  +  +S    +Q+  +L 
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324

Query: 1078 --RTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL--------LQRQK 1127
               TR    V+   + ++   +SL+   +EE++  +    H +  ++        LQ   
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 1128 ATV--LENSK---------LTGKISELERMVAELKKQKSRVEEELPKVREAAENE----- 1171
            +TV  LE  K         LT +  E      +L+K K+R+++EL  +    +N+     
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 1172 -LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEA--------------AERELER 1216
             L K+QR  + +  ++    S+    R   E   REKE               A+ ELER
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 1217 VRQL------------------TIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258
              ++                    E E  + A+E  +   + QLEE     +  ED   R
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564

Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQM-EKDLAFQKQVAEKQLKEKQKIEL 1317
             ++++  L+ Q  + ++   R   NEE+  +L +Q+ E +   + +  ++ L    K +L
Sbjct: 1565 LEVNMQALKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622

Query: 1318 EARRKITEIQYTC----RENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTA 1373
            E   K  E+Q       RE A+      QA         Q +  +++ E+ +   DE+ A
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQA---------QMKDFQRELEDARASRDEIFA 1673

Query: 1374 ANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKG 1433
              ++ E+  + L  +L  LQ E  ++ E+AR   D   E       L  EL         
Sbjct: 1674 TAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEE------LAEELASSLSGRNA 1726

Query: 1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRA 1493
               + R L  ++ Q   + EE       +    R    + E L++E    +    +   A
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 1494 HAVAEKNIQHLNSQIHSFRD---EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKE 1550
                E+  + L S++H        K    +   + K   L+EQ E+   +     K+ K+
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846

Query: 1551 NNDKIQRLNEELEKSNECAEMLKQ-------KVEELTRQNNETKLMMQRIQAESENIVLE 1603
             + K++ +  ++E   + AE  K+       +V++L RQ  E +   QRI A    +  E
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906

Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNE 1630
                 +  EA+  + +  K +LR  NE
Sbjct: 1907 LDEATESNEAMGREVNALKSKLRRGNE 1933



 Score =  124 bits (311), Expect = 1e-27
 Identities = 215/989 (21%), Positives = 408/989 (41%), Gaps = 143/989 (14%)

Query: 673  TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS---DITQLEKEVNVCKQYYQEL-LKS 728
            T L  +H+ ++S L+ R +   +  QE +        D +   +++   +    EL ++ 
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK--L 786
            A++EE+ ++       E+      L+   + L   I    E  D   +     E++K  L
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 787  KKELERLKDDL-GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDK 844
             +ELE LK +L  T+ +   +   +A     V  L+  L+   ++   QV  M   +   
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 845  LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH 904
            ++ +   L+  + A+A +   +  L +E A +A +      +  L Q + EV+ K++   
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQEVEHKKKKLE 1258

Query: 905  ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 964
            A   ELQ   +              D +  + + +  V + QN    +   L + EG  K
Sbjct: 1259 AQVQELQSKCS--------------DGERARAELNDKVHKLQNEVESVTGMLNEAEG--K 1302

Query: 965  SLKYYRDTYHPLDDWIQQVETTQRKIQEN--QPENSKTLATQLNQQK-----MLVSEIEM 1017
            ++K  +D    +     Q++ TQ  +QE   Q  N  T   QL +++      L  E+E 
Sbjct: 1303 AIKLAKD----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358

Query: 1018 KQS----------KMDECQKYAEQYSATV-----------KDYELQTMTYRAMVDSQQKS 1056
            KQ+          ++ + +K  + +++TV           K+ E  T  Y     +  K 
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418

Query: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116
               + R+Q   D ++   +DL  +   +  L  +  KF  D L   EE+ I         
Sbjct: 1419 EKTKNRLQQELDDLV---VDLDNQRQLVSNLEKKQRKF--DQLLA-EEKNIS-------- 1464

Query: 1117 GAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQ 1176
              Y+D   R +A   E       ++       E K++  R  + L    E   +      
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524

Query: 1177 RNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLL 1236
            +NV ++   K   E++ ++ + +LE +  E +A E   +   +L +  +A +   E +L 
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDL- 1580

Query: 1237 NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL-----I 1291
              + + E+N   RR L+  L   +  L D E+++  L    ++K + + + L+L     I
Sbjct: 1581 --QARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351
            K  E+ +  Q +  + Q+K+ Q+   +AR    EI  T +EN        +A S  A   
Sbjct: 1638 KGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENE------KKAKSLEADL- 1689

Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYEL---NALQLEKTSSEEKARLLKD 1408
            +Q + D   AE  ++Q D       + E+   EL   L   NALQ EK   E +   L++
Sbjct: 1690 MQLQEDLAAAERARKQAD------LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743

Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL---NQTTGKAEEAMQEASDLKK- 1464
            +L+E    +  +       D+  K  +QQ  +L  +L     T  K E A Q+     K 
Sbjct: 1744 ELEEEQGNMEAMS------DRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 1465 -----------IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD 1513
                       +K  ++  + +L  +  +L+ +V++  R    A K+++  + ++     
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 1514 EKELERLQICQRKSDHLKEQFEKSH---EQLLQNIKAEKE-------NNDKIQRLNEELE 1563
            + E ER     + ++  KEQ EK +   +QL + ++  +E       N  K+QR  +E  
Sbjct: 1857 QVEDER-----KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911

Query: 1564 KSNECAEMLKQKVEELTRQNNETKLMMQR 1592
            +SNE        ++   R+ NET  +  R
Sbjct: 1912 ESNEAMGREVNALKSKLRRGNETSFVPSR 1940



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 220/1120 (19%), Positives = 439/1120 (39%), Gaps = 192/1120 (17%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323
            K   L++ L E E  ++  +D        Q+Q +R +    +  +E  LE  +   + ++
Sbjct: 916  KKQELEEILHEMEARLEEEEDR-----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970

Query: 324  EFESSLKEAKISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQE---RHLDTLH 376
              E    EAKI +++    +      KL +    LE + + L      +E   ++L  L 
Sbjct: 971  -LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 377  NFVSRATNELIWLNEKEEE----------EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
            N      +EL    +KEE+          ++  D S+ +  IA  +   AEL  +L +KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 427  ENIKSV-----QEIAEQ-------LLLENHPARL--TIEAYRAAMQTQWSWILQLCQCVE 472
            E +++       EIA++         LE H + L   +++ RAA          L + +E
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149

Query: 473  ------QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526
                  +   ++TA  +     +E    +  LK A+  + +    + + ++     +++E
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALDEE-TRSHEAQVQEMRQKHAQAVE 1206

Query: 527  E-KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585
            E  E+L Q+K   ANL    +T   L+  N+D                         +  
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQT---LEKENAD----------------------LAGELR 1241

Query: 586  VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHI 645
            VL       + K          + S C        E  D  ++++ + ++V  + +E+  
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301

Query: 646  NMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSG 705
                +              A +VAS+ + L               ++ L++    ++   
Sbjct: 1302 KAIKL--------------AKDVASLSSQLQDT------------QELLQEETRQKLNVS 1335

Query: 706  SDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLR--------LENCE 757
            + + QLE+E N  +    E +++ +  E+  S  N+ +S+ +  +L+        LE  +
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK-KLQDFASTVEALEEGK 1394

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R  ++I    ++    E      + EK K  L++  DDL    +   +          V
Sbjct: 1395 KRFQKEIENLTQQ--YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---------V 1443

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYID------------KLKTVNLVLKNTQAAEALVKLY 865
              L  +     Q + +  ++SS Y D            + K ++L     +A EA  +L 
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503

Query: 866  ETK---LCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQVFHALEDELQKAK---- 914
             T      E E +++ K+    N+  L  + +   ++++E +     LEDELQ  +    
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563

Query: 915  --AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972
               ++ +  K   ERDL     + + +Q  E+ + +  Q+     +LE   K        
Sbjct: 1564 RLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618

Query: 973  YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY 1032
               L+  ++ +E       + + E  K L     Q K    E+E  ++  DE        
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE-------I 1671

Query: 1033 SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM-DLRTRYTALVTLMTQY 1091
             AT K+ E +  +  A +   Q+      R +  ADL  +E   +L +  +    L    
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ--- 1728

Query: 1092 IKFAGDSLKRLE------EEEIKRCKETSEHGAYSDLLQR--QKATVLENSKLTGKISEL 1143
                 D  +RLE      EEE++  +E     A SD +++  Q+A  L N   T      
Sbjct: 1729 -----DEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELAT------ 1775

Query: 1144 ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRA-ESEAKQYRRELET 1202
            ER  A+ K + +R  ++L +  +   ++L + +  V+      I A E++  Q   ++E 
Sbjct: 1776 ERSTAQ-KNESAR--QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832

Query: 1203 IVREKEAAEREL----ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258
              REK+AA + L    ++++++ ++ E +R   E+    ++ Q E+     + L+  L+ 
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ----YKEQAEKGNARVKQLKRQLEE 1888

Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL 1298
             +     +   + KL  EL    ++ E + + +  ++  L
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 109/524 (20%), Positives = 217/524 (41%), Gaps = 80/524 (15%)

Query: 1541 LLQNIKAEKE---NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597
            LLQ  + E+E     D++Q+  E  +K+    + L+QK  +LT + N   L+ +++QAE+
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQEQLQAET 900

Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657
            E        +    E ++++    K +L    E LH+              LEE+  + Q
Sbjct: 901  E--------LYAEAEEMRVRLAAKKQEL---EEILHEMEAR----------LEEEEDRGQ 939

Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLK 1717
             L +E K+   Q                 +L    EE+    QK+QL++   +    ++K
Sbjct: 940  QLQAERKKMAQQM---------------LDLEEQLEEEEAARQKLQLEKVTAEA---KIK 981

Query: 1718 KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL 1777
            K++DE+ +   +     ++  L +E       +  E  +K + L + K   E+ IS +  
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE- 1040

Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDEL-- 1835
              V L++E    QE  KL     ++LE     + EQ+   Q   A    +  K E+EL  
Sbjct: 1041 --VRLKKEEKSRQELEKL----KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094

Query: 1836 --------IAQKREVENLKQKMDQQIKEHEHQL-----VLLQCEIQKKSTAKDC-TFKPD 1881
                    IAQK       ++++  I + +  L        + E QK+   ++    K +
Sbjct: 1095 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154

Query: 1882 FEMTVKECQHSGELSSRNTGHLHPTPRS-PLLRWTQEPQPLEEKWQH-RVVEQIPKEV-Q 1938
             E T+       EL ++    +    ++      + E Q  E + +H + VE++ +++ Q
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 1939 FQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRL-----SEIEKIRDQALNNS 1993
            F+   A L+K K  Q   +  +  + EL++       +        +++++++ +  +  
Sbjct: 1215 FKRAKANLDKNK--QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272

Query: 1994 RPPVRYQDNACEM--ELVKVLTPLEIAKNKQYDMHTEVTTLKQE 2035
            R      D   ++  E+  V   L  A+ K   +  +V +L  +
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  155 bits (391), Expect = 7e-37
 Identities = 208/1036 (20%), Positives = 444/1036 (42%), Gaps = 102/1036 (9%)

Query: 895  EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954
            +V  + +   A EDELQK K                    ++KA+  ++  +  H Q+  
Sbjct: 853  QVTRQEEEMQAKEDELQKTKE------------------RQQKAENELKELEQKHSQLTE 894

Query: 955  RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
                L+   + L+   + Y   ++   ++   +++++E   E    L  + ++ + L +E
Sbjct: 895  EKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV----KRRRMQSSADLI 1070
             +    +M + ++  E+  A  +  +L+ +T  A +   +   +    +  ++     L+
Sbjct: 952  RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011

Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130
             +   DL T             K        + E E++  KE         L ++ +   
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-- 1069

Query: 1131 LENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-A 1189
             + S    +I++L+  +AELK Q ++ EEEL       ++E+ ++       +L+KIR  
Sbjct: 1070 -DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-----ALKKIREL 1123

Query: 1190 ESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE------ 1243
            E      + +L++   E+ A  +  ++ R L  E EA +  +E+ L +   Q E      
Sbjct: 1124 EGHISDLQEDLDS---ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180

Query: 1244 -ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEEL-------RRKRDNEEELLKLIKQME 1295
             E T  ++ L++  +  +  + ++ Q+  + +EEL       +R + N ++  + +++  
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240

Query: 1296 KDLAFQKQV--AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ-----ATSCRA 1348
             DLA + +V    KQ  E +K +LEA  ++ E+Q  C +       +            +
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEA--QVQELQSKCSDGERARAELNDKVHKLQNEVES 1298

Query: 1349 VTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408
            VTG+  E +  KA +L + V  L++  +  ++ ++E T +   +  +    EE+   L+D
Sbjct: 1299 VTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357

Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRN 1468
            +LDE          E+E K   E+     +  L  QL+ +  K ++       L++ K+ 
Sbjct: 1358 QLDE----------EMEAKQNLER----HISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528
            +Q E+E+L  +  +     D++ +     ++ +  L   + + R  + +  L+  QRK D
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFD 1461

Query: 1529 H-LKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587
              L E+   S +   +  +AE E  +K     + L  +    E L+ K EEL R N   K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARALEEALEAK-EELERTNKMLK 1517

Query: 1588 LMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIK 1647
              M+ + +  +++      +++   AL+ Q +  K QL    E L  + +  +D + +++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLE 1573

Query: 1648 CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQA 1707
                     Q L  +F++  D Q    QN +K  R L  +L+  + E     ++  L  A
Sbjct: 1574 ------VNMQALKGQFER--DLQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAA 1624

Query: 1708 QVQELNNRLK--KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESK 1765
              ++L   LK  ++Q +  +K  EE +  +++   Q +   F++  E+ R   +++  + 
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825
               E     +  D + LQ++ + A+   K  +   +EL  +L          Q  +    
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 1826 QKCQKLEDELIAQKREVENLK---QKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882
             +  +LE+EL  ++  +E +    +K  QQ ++  ++L   +   QK  +A+    + + 
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802

Query: 1883 EMTVKECQHSGELSSR 1898
            E+  K  +  G + S+
Sbjct: 1803 ELRSKLHEMEGAVKSK 1818



 Score =  146 bits (368), Expect = 3e-34
 Identities = 214/1136 (18%), Positives = 488/1136 (42%), Gaps = 124/1136 (10%)

Query: 769  ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF-SQAAASSSVPTLRSELNVV 827
            + D+L ++  R  + E   KELE+    L    N  +E   ++    +    +R  L   
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 828  LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 887
             Q + ++       +++ +     L+  +   A   L   +  EEE     K  +E + +
Sbjct: 924  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 888  TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 947
              K    +++++  V     ++L K + + +E          + +   +   +L  + ++
Sbjct: 984  EAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041

Query: 948  VHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006
            +  +++ RL+  E   + L K  R       D+ +Q+   Q +I E        L  QL 
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLA 1093

Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066
            +++    E++   +++D+  + A++ +A  K  EL+        D   +   + +  +  
Sbjct: 1094 KKE---EELQAALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 1067 ADLIIQEFMDLRTRYT-ALVTLMTQYIKFAGDSLKRLEEEEIKRCK-----ETSEHGAYS 1120
             DL  +E   L+T     L +  TQ        L+   E+E+   K     ET  H A  
Sbjct: 1149 RDLG-EELEALKTELEDTLDSTATQ------QELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP------KVREAAENELRK 1174
              ++++ A  +E  +LT ++ + +R  A L K K  +E+E        +V   A+ E+  
Sbjct: 1202 QEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 1175 QQRNVEDISLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEE 1233
            +++ +E   +Q+++++ S+ ++ R EL   V +    + E+E V  +  EAE K   + +
Sbjct: 1260 KKKKLE-AQVQELQSKCSDGERARAELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAK 1315

Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRK---DLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290
            ++ +  +QL++   T+  L++  ++K      L  LE+++N L ++L  + + ++ L + 
Sbjct: 1316 DVASLSSQLQD---TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVT 1350
            I  +   L+  K+  +      + +E   +R   EI                        
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI------------------------ 1408

Query: 1351 GLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKL 1410
                E+  Q+ EE     D+L     + +Q++ +L  +L+  +   ++ E+K R     L
Sbjct: 1409 ----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470
             E  N       E +R +   +    +   L R L       EEA++   +L++  +  +
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARAL-------EEALEAKEELERTNKMLK 1517

Query: 1471 LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELE-----RLQICQR 1525
             E+E L   K  + + V  + ++    E  ++ + +Q+    DE +       RL++  +
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL-EKSNECAEMLKQK-VEELTRQN 1583
                LK QFE+  +        +++N +K ++L  +L E   E  +  KQ+ +    ++ 
Sbjct: 1578 A---LKGQFERDLQA------RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643
             E  L    +QA+S   +  ++   ++   L+ Q   F+ +L        +   T ++ +
Sbjct: 1629 LEGDLKDLELQADSA--IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

Query: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703
            +K K LE DL + Q  ++  ++   Q ++  +   +E+ +  +  NA ++EKRR E ++ 
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL-- 1761
              + +++E    ++ + D +   T + +    ++   +  + K + + ++  ++ ++L  
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806

Query: 1762 ----MESKVITE--NDISGIRLDFVSLQQ-------ENSRAQENAKLCETNIKEL----- 1803
                ME  V ++  + I+ +      L++       E   A ++ K  +  +KE+     
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866

Query: 1804 -ERQL-QQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             ER++ +QY+EQ ++G        ++ ++ E+E          L++++D+  + +E
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922



 Score =  140 bits (353), Expect = 2e-32
 Identities = 225/1172 (19%), Positives = 485/1172 (41%), Gaps = 190/1172 (16%)

Query: 691  EDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIR 750
            ED L+ ++E Q  + +++ +LE++ +   Q  +E     E+ + E  +Y    +E   +R
Sbjct: 865  EDELQKTKERQQKAENELKELEQKHS---QLTEEKNLLQEQLQAETELY----AEAEEMR 917

Query: 751  LRLENCEDRLIRQIRTPLERDDLHESVFRITEQE----KLKKELERLKDDLGTITNKCEE 806
            +RL   +  L          + LHE   R+ E+E    +L+ E +++   +  +  + EE
Sbjct: 918  VRLAAKKQEL---------EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 807  F--------FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858
                       +  A + +  L  E+ +V+ + N                N + K  +  
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEI-LVMDDQN----------------NKLSKERKLL 1011

Query: 859  EALVKLYETKLCEEEAVIAD----KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAK 914
            E  +    T L EEE    +    KN  E++IS L+    + ++ RQ    L+ +L+   
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071

Query: 915  AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974
            +                D+H++ AD L  +   + +Q+  +  +L+              
Sbjct: 1072 S----------------DFHEQIAD-LQAQIAELKMQLAKKEEELQA----------ALA 1104

Query: 975  PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1034
             LDD I Q     +KI+E +   S  L   L+ ++   ++ E ++  + E     E    
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGE---ELEALKT 1160

Query: 1035 TVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093
             ++D    T T + +    +Q+  V ++ +         +  ++R ++   V  +T+ + 
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219

Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LENSKLTGKISELERMVAELKK 1152
                       E+ KR K           L + K T+  EN+ L G++  L +   E++ 
Sbjct: 1220 -----------EQFKRAKAN---------LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 1153 QKSRVEEELPKVR------EAAENELR----KQQRNVEDISLQKIRAESEAKQYRRELET 1202
            +K ++E ++ +++      E A  EL     K Q  VE ++     AE +A +  +++ +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262
            +  + +  +  L+   +  +    K   +EE   + ++QL+E    ++ LE H+   ++ 
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 1263 LND------------------------------------------LEQQKNKLMEELRR- 1279
            L+D                                          LE+ KN+L +EL   
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439

Query: 1280 --KRDNEEELLKLIKQMEKD----LAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR-- 1331
                DN+ +L+  +++ ++     LA +K ++ K   E+ + E EAR K T+     R  
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 1332 ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNA 1391
            E AL      + T+   +   + E      +++ + V EL  + R  E  M E+  +L  
Sbjct: 1500 EEALEAKEELERTN--KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 1392 LQLEKTSSEE-KARLLKDKLDETNNTLRCLKLELERKDQA-EKGYSQQLRELGRQLNQTT 1449
            L+ E  ++E+ K RL      E N  ++ LK + ER  QA ++   ++ R+L RQL++  
Sbjct: 1558 LEDELQATEDAKLRL------EVN--MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609

Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIH 1509
             + E+  ++ +     K+  + +L+ L       + + D   +    A K ++ L +Q+ 
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDL-------ELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 1510 SFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE-KSNEC 1568
             F  ++ELE  +  + +     ++ EK  + L  ++   +E+    +R  ++ + +  E 
Sbjct: 1663 DF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720

Query: 1569 AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK---QTIQQRCEALKIQADGFKDQL 1625
            AE L   +       +E + +  RI    E +  E+   + +  R      QA+   ++L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV-SEFKQKCDQQNIIIQNTKKEVRNL 1684
             +      K     Q  +R+ K L   L + +  V S+FK         I   +++V   
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744
              E  A+ +  ++ ++K++    QV++     ++ +++        +   R++   +EES
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIR 1776
             +   +  + ++++++  ES      +++ ++
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALK 1932



 Score =  129 bits (325), Expect = 3e-29
 Identities = 225/1107 (20%), Positives = 446/1107 (40%), Gaps = 149/1107 (13%)

Query: 627  NRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNL 686
            N +++  Q    L  E ++  + + +   L  E + +R    A  +     E +++L  +
Sbjct: 880  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEM 934

Query: 687  QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEV 746
            ++R E+  E+ +  Q+       Q E+     K+  Q++L   E+ E+EE+       E 
Sbjct: 935  EARLEE--EEDRGQQL-------QAER-----KKMAQQMLDLEEQLEEEEAARQKLQLEK 980

Query: 747  RNIRLRLENCEDRLI----RQIRTPLERDDLHESVFRIT----EQEKLKKELERLKDDLG 798
                 +++  ED ++    +  +   ER  L E +  +T    E+E+  K L +LK+   
Sbjct: 981  VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

Query: 799  TITNKCEEFFSQAAAS-SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 857
            ++ ++ E    +   S   +  L+ +L     + ++  +     I +LK + L  K  + 
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-MQLAKKEEEL 1099

Query: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA-I 916
              AL +L +         IA KNN    I  L+   S++ E      A  ++ +K K  +
Sbjct: 1100 QAALARLDDE--------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 917  SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHV---QIDNRLRDLEGIGKSLKY-YRDT 972
             +E+     E +   D    + +   +R Q V V    +D   R  E   + ++  +   
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 973  YHPLDDWIQQVETTQRKIQENQPENSKT---LATQL-----------NQQKMLVSEIEMK 1018
               L + ++Q +  +  + +N+    K    LA +L           +++K L ++++  
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271

Query: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL- 1077
            QSK  + ++   + +  V   + +  +   M++  +   +K  +  +S    +Q+  +L 
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331

Query: 1078 --RTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL--------LQRQK 1127
               TR    V+   + ++   +SL+   +EE++  +    H +  ++        LQ   
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 1128 ATV--LENSK---------LTGKISELERMVAELKKQKSRVEEELPKVREAAENE----- 1171
            +TV  LE  K         LT +  E      +L+K K+R+++EL  +    +N+     
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 1172 -LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEA--------------AERELER 1216
             L K+QR  + +  ++    S+    R   E   REKE               A+ ELER
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 1217 VRQL------------------TIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258
              ++                    E E  + A+E  +   + QLEE     +  ED   R
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571

Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQM-EKDLAFQKQVAEKQLKEKQKIEL 1317
             ++++  L+ Q  + ++   R   NEE+  +L +Q+ E +   + +  ++ L    K +L
Sbjct: 1572 LEVNMQALKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629

Query: 1318 EARRKITEIQYTC----RENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTA 1373
            E   K  E+Q       RE A+      QA         Q +  +++ E+ +   DE+ A
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQA---------QMKDFQRELEDARASRDEIFA 1680

Query: 1374 ANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKG 1433
              ++ E+  + L  +L  LQ E  ++ E+AR   D   E       L  EL         
Sbjct: 1681 TAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEE------LAEELASSLSGRNA 1733

Query: 1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRA 1493
               + R L  ++ Q   + EE       +    R    + E L++E    +    +   A
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 1494 HAVAEKNIQHLNSQIHSFRD---EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKE 1550
                E+  + L S++H        K    +   + K   L+EQ E+   +     K+ K+
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853

Query: 1551 NNDKIQRLNEELEKSNECAEMLKQ-------KVEELTRQNNETKLMMQRIQAESENIVLE 1603
             + K++ +  ++E   + AE  K+       +V++L RQ  E +   QRI A    +  E
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913

Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNE 1630
                 +  EA+  + +  K +LR  NE
Sbjct: 1914 LDEATESNEAMGREVNALKSKLRRGNE 1940



 Score =  124 bits (311), Expect = 1e-27
 Identities = 215/989 (21%), Positives = 408/989 (41%), Gaps = 143/989 (14%)

Query: 673  TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS---DITQLEKEVNVCKQYYQEL-LKS 728
            T L  +H+ ++S L+ R +   +  QE +        D +   +++   +    EL ++ 
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK--L 786
            A++EE+ ++       E+      L+   + L   I    E  D   +     E++K  L
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 787  KKELERLKDDL-GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDK 844
             +ELE LK +L  T+ +   +   +A     V  L+  L+   ++   QV  M   +   
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 845  LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH 904
            ++ +   L+  + A+A +   +  L +E A +A +      +  L Q + EV+ K++   
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQEVEHKKKKLE 1265

Query: 905  ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 964
            A   ELQ   +              D +  + + +  V + QN    +   L + EG  K
Sbjct: 1266 AQVQELQSKCS--------------DGERARAELNDKVHKLQNEVESVTGMLNEAEG--K 1309

Query: 965  SLKYYRDTYHPLDDWIQQVETTQRKIQEN--QPENSKTLATQLNQQK-----MLVSEIEM 1017
            ++K  +D    +     Q++ TQ  +QE   Q  N  T   QL +++      L  E+E 
Sbjct: 1310 AIKLAKD----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365

Query: 1018 KQS----------KMDECQKYAEQYSATV-----------KDYELQTMTYRAMVDSQQKS 1056
            KQ+          ++ + +K  + +++TV           K+ E  T  Y     +  K 
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425

Query: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116
               + R+Q   D ++   +DL  +   +  L  +  KF  D L   EE+ I         
Sbjct: 1426 EKTKNRLQQELDDLV---VDLDNQRQLVSNLEKKQRKF--DQLLA-EEKNIS-------- 1471

Query: 1117 GAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQ 1176
              Y+D   R +A   E       ++       E K++  R  + L    E   +      
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531

Query: 1177 RNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLL 1236
            +NV ++   K   E++ ++ + +LE +  E +A E   +   +L +  +A +   E +L 
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDL- 1587

Query: 1237 NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL-----I 1291
              + + E+N   RR L+  L   +  L D E+++  L    ++K + + + L+L     I
Sbjct: 1588 --QARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351
            K  E+ +  Q +  + Q+K+ Q+   +AR    EI  T +EN        +A S  A   
Sbjct: 1645 KGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENE------KKAKSLEADL- 1696

Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYEL---NALQLEKTSSEEKARLLKD 1408
            +Q + D   AE  ++Q D       + E+   EL   L   NALQ EK   E +   L++
Sbjct: 1697 MQLQEDLAAAERARKQAD------LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750

Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL---NQTTGKAEEAMQEASDLKK- 1464
            +L+E    +  +       D+  K  +QQ  +L  +L     T  K E A Q+     K 
Sbjct: 1751 ELEEEQGNMEAMS------DRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 1465 -----------IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD 1513
                       +K  ++  + +L  +  +L+ +V++  R    A K+++  + ++     
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 1514 EKELERLQICQRKSDHLKEQFEKSH---EQLLQNIKAEKE-------NNDKIQRLNEELE 1563
            + E ER     + ++  KEQ EK +   +QL + ++  +E       N  K+QR  +E  
Sbjct: 1864 QVEDER-----KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918

Query: 1564 KSNECAEMLKQKVEELTRQNNETKLMMQR 1592
            +SNE        ++   R+ NET  +  R
Sbjct: 1919 ESNEAMGREVNALKSKLRRGNETSFVPSR 1947



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 220/1120 (19%), Positives = 439/1120 (39%), Gaps = 192/1120 (17%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323
            K   L++ L E E  ++  +D        Q+Q +R +    +  +E  LE  +   + ++
Sbjct: 923  KKQELEEILHEMEARLEEEEDR-----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

Query: 324  EFESSLKEAKISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQE---RHLDTLH 376
              E    EAKI +++    +      KL +    LE + + L      +E   ++L  L 
Sbjct: 978  -LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 377  NFVSRATNELIWLNEKEEE----------EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
            N      +EL    +KEE+          ++  D S+ +  IA  +   AEL  +L +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 427  ENIKSV-----QEIAEQ-------LLLENHPARL--TIEAYRAAMQTQWSWILQLCQCVE 472
            E +++       EIA++         LE H + L   +++ RAA          L + +E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156

Query: 473  ------QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526
                  +   ++TA  +     +E    +  LK A+  + +    + + ++     +++E
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALDEE-TRSHEAQVQEMRQKHAQAVE 1213

Query: 527  E-KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585
            E  E+L Q+K   ANL    +T   L+  N+D                         +  
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQT---LEKENAD----------------------LAGELR 1248

Query: 586  VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHI 645
            VL       + K          + S C        E  D  ++++ + ++V  + +E+  
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 646  NMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSG 705
                +              A +VAS+ + L               ++ L++    ++   
Sbjct: 1309 KAIKL--------------AKDVASLSSQLQDT------------QELLQEETRQKLNVS 1342

Query: 706  SDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLR--------LENCE 757
            + + QLE+E N  +    E +++ +  E+  S  N+ +S+ +  +L+        LE  +
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK-KLQDFASTVEALEEGK 1401

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R  ++I    ++    E      + EK K  L++  DDL    +   +          V
Sbjct: 1402 KRFQKEIENLTQQ--YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---------V 1450

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYID------------KLKTVNLVLKNTQAAEALVKLY 865
              L  +     Q + +  ++SS Y D            + K ++L     +A EA  +L 
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 866  ETK---LCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQVFHALEDELQKAK---- 914
             T      E E +++ K+    N+  L  + +   ++++E +     LEDELQ  +    
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570

Query: 915  --AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972
               ++ +  K   ERDL     + + +Q  E+ + +  Q+     +LE   K        
Sbjct: 1571 RLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625

Query: 973  YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY 1032
               L+  ++ +E       + + E  K L     Q K    E+E  ++  DE        
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE-------I 1678

Query: 1033 SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM-DLRTRYTALVTLMTQY 1091
             AT K+ E +  +  A +   Q+      R +  ADL  +E   +L +  +    L    
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ--- 1735

Query: 1092 IKFAGDSLKRLE------EEEIKRCKETSEHGAYSDLLQR--QKATVLENSKLTGKISEL 1143
                 D  +RLE      EEE++  +E     A SD +++  Q+A  L N   T      
Sbjct: 1736 -----DEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELAT------ 1782

Query: 1144 ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRA-ESEAKQYRRELET 1202
            ER  A+ K + +R  ++L +  +   ++L + +  V+      I A E++  Q   ++E 
Sbjct: 1783 ERSTAQ-KNESAR--QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 1203 IVREKEAAEREL----ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258
              REK+AA + L    ++++++ ++ E +R   E+    ++ Q E+     + L+  L+ 
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ----YKEQAEKGNARVKQLKRQLEE 1895

Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL 1298
             +     +   + KL  EL    ++ E + + +  ++  L
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 109/524 (20%), Positives = 217/524 (41%), Gaps = 80/524 (15%)

Query: 1541 LLQNIKAEKE---NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597
            LLQ  + E+E     D++Q+  E  +K+    + L+QK  +LT + N   L+ +++QAE+
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQEQLQAET 907

Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657
            E        +    E ++++    K +L    E LH+              LEE+  + Q
Sbjct: 908  E--------LYAEAEEMRVRLAAKKQEL---EEILHEMEAR----------LEEEEDRGQ 946

Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLK 1717
             L +E K+   Q                 +L    EE+    QK+QL++   +    ++K
Sbjct: 947  QLQAERKKMAQQM---------------LDLEEQLEEEEAARQKLQLEKVTAEA---KIK 988

Query: 1718 KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL 1777
            K++DE+ +   +     ++  L +E       +  E  +K + L + K   E+ IS +  
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE- 1047

Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDEL-- 1835
              V L++E    QE  KL     ++LE     + EQ+   Q   A    +  K E+EL  
Sbjct: 1048 --VRLKKEEKSRQELEKL----KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101

Query: 1836 --------IAQKREVENLKQKMDQQIKEHEHQL-----VLLQCEIQKKSTAKDC-TFKPD 1881
                    IAQK       ++++  I + +  L        + E QK+   ++    K +
Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161

Query: 1882 FEMTVKECQHSGELSSRNTGHLHPTPRS-PLLRWTQEPQPLEEKWQH-RVVEQIPKEV-Q 1938
             E T+       EL ++    +    ++      + E Q  E + +H + VE++ +++ Q
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 1939 FQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRL-----SEIEKIRDQALNNS 1993
            F+   A L+K K  Q   +  +  + EL++       +        +++++++ +  +  
Sbjct: 1222 FKRAKANLDKNK--QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279

Query: 1994 RPPVRYQDNACEM--ELVKVLTPLEIAKNKQYDMHTEVTTLKQE 2035
            R      D   ++  E+  V   L  A+ K   +  +V +L  +
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  155 bits (391), Expect = 7e-37
 Identities = 208/1036 (20%), Positives = 444/1036 (42%), Gaps = 102/1036 (9%)

Query: 895  EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954
            +V  + +   A EDELQK K                    ++KA+  ++  +  H Q+  
Sbjct: 853  QVTRQEEEMQAKEDELQKTKE------------------RQQKAENELKELEQKHSQLTE 894

Query: 955  RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
                L+   + L+   + Y   ++   ++   +++++E   E    L  + ++ + L +E
Sbjct: 895  EKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951

Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV----KRRRMQSSADLI 1070
             +    +M + ++  E+  A  +  +L+ +T  A +   +   +    +  ++     L+
Sbjct: 952  RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011

Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130
             +   DL T             K        + E E++  KE         L ++ +   
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-- 1069

Query: 1131 LENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-A 1189
             + S    +I++L+  +AELK Q ++ EEEL       ++E+ ++       +L+KIR  
Sbjct: 1070 -DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-----ALKKIREL 1123

Query: 1190 ESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE------ 1243
            E      + +L++   E+ A  +  ++ R L  E EA +  +E+ L +   Q E      
Sbjct: 1124 EGHISDLQEDLDS---ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180

Query: 1244 -ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEEL-------RRKRDNEEELLKLIKQME 1295
             E T  ++ L++  +  +  + ++ Q+  + +EEL       +R + N ++  + +++  
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240

Query: 1296 KDLAFQKQV--AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ-----ATSCRA 1348
             DLA + +V    KQ  E +K +LEA  ++ E+Q  C +       +            +
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEA--QVQELQSKCSDGERARAELNDKVHKLQNEVES 1298

Query: 1349 VTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408
            VTG+  E +  KA +L + V  L++  +  ++ ++E T +   +  +    EE+   L+D
Sbjct: 1299 VTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357

Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRN 1468
            +LDE          E+E K   E+     +  L  QL+ +  K ++       L++ K+ 
Sbjct: 1358 QLDE----------EMEAKQNLER----HISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528
            +Q E+E+L  +  +     D++ +     ++ +  L   + + R  + +  L+  QRK D
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFD 1461

Query: 1529 H-LKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587
              L E+   S +   +  +AE E  +K     + L  +    E L+ K EEL R N   K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARALEEALEAK-EELERTNKMLK 1517

Query: 1588 LMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIK 1647
              M+ + +  +++      +++   AL+ Q +  K QL    E L  + +  +D + +++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLE 1573

Query: 1648 CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQA 1707
                     Q L  +F++  D Q    QN +K  R L  +L+  + E     ++  L  A
Sbjct: 1574 ------VNMQALKGQFER--DLQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAA 1624

Query: 1708 QVQELNNRLK--KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESK 1765
              ++L   LK  ++Q +  +K  EE +  +++   Q +   F++  E+ R   +++  + 
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825
               E     +  D + LQ++ + A+   K  +   +EL  +L          Q  +    
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 1826 QKCQKLEDELIAQKREVENLK---QKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882
             +  +LE+EL  ++  +E +    +K  QQ ++  ++L   +   QK  +A+    + + 
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802

Query: 1883 EMTVKECQHSGELSSR 1898
            E+  K  +  G + S+
Sbjct: 1803 ELRSKLHEMEGAVKSK 1818



 Score =  146 bits (368), Expect = 3e-34
 Identities = 214/1136 (18%), Positives = 488/1136 (42%), Gaps = 124/1136 (10%)

Query: 769  ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF-SQAAASSSVPTLRSELNVV 827
            + D+L ++  R  + E   KELE+    L    N  +E   ++    +    +R  L   
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 828  LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 887
             Q + ++       +++ +     L+  +   A   L   +  EEE     K  +E + +
Sbjct: 924  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 888  TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 947
              K    +++++  V     ++L K + + +E          + +   +   +L  + ++
Sbjct: 984  EAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041

Query: 948  VHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006
            +  +++ RL+  E   + L K  R       D+ +Q+   Q +I E        L  QL 
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLA 1093

Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066
            +++    E++   +++D+  + A++ +A  K  EL+        D   +   + +  +  
Sbjct: 1094 KKE---EELQAALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 1067 ADLIIQEFMDLRTRYT-ALVTLMTQYIKFAGDSLKRLEEEEIKRCK-----ETSEHGAYS 1120
             DL  +E   L+T     L +  TQ        L+   E+E+   K     ET  H A  
Sbjct: 1149 RDLG-EELEALKTELEDTLDSTATQ------QELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP------KVREAAENELRK 1174
              ++++ A  +E  +LT ++ + +R  A L K K  +E+E        +V   A+ E+  
Sbjct: 1202 QEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 1175 QQRNVEDISLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEE 1233
            +++ +E   +Q+++++ S+ ++ R EL   V +    + E+E V  +  EAE K   + +
Sbjct: 1260 KKKKLE-AQVQELQSKCSDGERARAELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAK 1315

Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRK---DLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290
            ++ +  +QL++   T+  L++  ++K      L  LE+++N L ++L  + + ++ L + 
Sbjct: 1316 DVASLSSQLQD---TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVT 1350
            I  +   L+  K+  +      + +E   +R   EI                        
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI------------------------ 1408

Query: 1351 GLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKL 1410
                E+  Q+ EE     D+L     + +Q++ +L  +L+  +   ++ E+K R     L
Sbjct: 1409 ----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470
             E  N       E +R +   +    +   L R L       EEA++   +L++  +  +
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARAL-------EEALEAKEELERTNKMLK 1517

Query: 1471 LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELE-----RLQICQR 1525
             E+E L   K  + + V  + ++    E  ++ + +Q+    DE +       RL++  +
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL-EKSNECAEMLKQK-VEELTRQN 1583
                LK QFE+  +        +++N +K ++L  +L E   E  +  KQ+ +    ++ 
Sbjct: 1578 A---LKGQFERDLQA------RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643
             E  L    +QA+S   +  ++   ++   L+ Q   F+ +L        +   T ++ +
Sbjct: 1629 LEGDLKDLELQADSA--IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

Query: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703
            +K K LE DL + Q  ++  ++   Q ++  +   +E+ +  +  NA ++EKRR E ++ 
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL-- 1761
              + +++E    ++ + D +   T + +    ++   +  + K + + ++  ++ ++L  
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806

Query: 1762 ----MESKVITE--NDISGIRLDFVSLQQ-------ENSRAQENAKLCETNIKEL----- 1803
                ME  V ++  + I+ +      L++       E   A ++ K  +  +KE+     
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866

Query: 1804 -ERQL-QQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
             ER++ +QY+EQ ++G        ++ ++ E+E          L++++D+  + +E
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922



 Score =  140 bits (353), Expect = 2e-32
 Identities = 225/1172 (19%), Positives = 485/1172 (41%), Gaps = 190/1172 (16%)

Query: 691  EDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIR 750
            ED L+ ++E Q  + +++ +LE++ +   Q  +E     E+ + E  +Y    +E   +R
Sbjct: 865  EDELQKTKERQQKAENELKELEQKHS---QLTEEKNLLQEQLQAETELY----AEAEEMR 917

Query: 751  LRLENCEDRLIRQIRTPLERDDLHESVFRITEQE----KLKKELERLKDDLGTITNKCEE 806
            +RL   +  L          + LHE   R+ E+E    +L+ E +++   +  +  + EE
Sbjct: 918  VRLAAKKQEL---------EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 807  F--------FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858
                       +  A + +  L  E+ +V+ + N                N + K  +  
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEI-LVMDDQN----------------NKLSKERKLL 1011

Query: 859  EALVKLYETKLCEEEAVIAD----KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAK 914
            E  +    T L EEE    +    KN  E++IS L+    + ++ RQ    L+ +L+   
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071

Query: 915  AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974
            +                D+H++ AD L  +   + +Q+  +  +L+              
Sbjct: 1072 S----------------DFHEQIAD-LQAQIAELKMQLAKKEEELQA----------ALA 1104

Query: 975  PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1034
             LDD I Q     +KI+E +   S  L   L+ ++   ++ E ++  + E     E    
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGE---ELEALKT 1160

Query: 1035 TVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093
             ++D    T T + +    +Q+  V ++ +         +  ++R ++   V  +T+ + 
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219

Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LENSKLTGKISELERMVAELKK 1152
                       E+ KR K           L + K T+  EN+ L G++  L +   E++ 
Sbjct: 1220 -----------EQFKRAKAN---------LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 1153 QKSRVEEELPKVR------EAAENELR----KQQRNVEDISLQKIRAESEAKQYRRELET 1202
            +K ++E ++ +++      E A  EL     K Q  VE ++     AE +A +  +++ +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262
            +  + +  +  L+   +  +    K   +EE   + ++QL+E    ++ LE H+   ++ 
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 1263 LND------------------------------------------LEQQKNKLMEELRR- 1279
            L+D                                          LE+ KN+L +EL   
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439

Query: 1280 --KRDNEEELLKLIKQMEKD----LAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR-- 1331
                DN+ +L+  +++ ++     LA +K ++ K   E+ + E EAR K T+     R  
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 1332 ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNA 1391
            E AL      + T+   +   + E      +++ + V EL  + R  E  M E+  +L  
Sbjct: 1500 EEALEAKEELERTN--KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 1392 LQLEKTSSEE-KARLLKDKLDETNNTLRCLKLELERKDQA-EKGYSQQLRELGRQLNQTT 1449
            L+ E  ++E+ K RL      E N  ++ LK + ER  QA ++   ++ R+L RQL++  
Sbjct: 1558 LEDELQATEDAKLRL------EVN--MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609

Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIH 1509
             + E+  ++ +     K+  + +L+ L       + + D   +    A K ++ L +Q+ 
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDL-------ELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 1510 SFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE-KSNEC 1568
             F  ++ELE  +  + +     ++ EK  + L  ++   +E+    +R  ++ + +  E 
Sbjct: 1663 DF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720

Query: 1569 AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK---QTIQQRCEALKIQADGFKDQL 1625
            AE L   +       +E + +  RI    E +  E+   + +  R      QA+   ++L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV-SEFKQKCDQQNIIIQNTKKEVRNL 1684
             +      K     Q  +R+ K L   L + +  V S+FK         I   +++V   
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744
              E  A+ +  ++ ++K++    QV++     ++ +++        +   R++   +EES
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIR 1776
             +   +  + ++++++  ES      +++ ++
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALK 1932



 Score =  125 bits (313), Expect = 7e-28
 Identities = 218/995 (21%), Positives = 403/995 (40%), Gaps = 137/995 (13%)

Query: 673  TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS---DITQLEKEVNVCKQYYQEL-LKS 728
            T L  +H+ ++S L+ R +   +  QE +        D +   +++   +    EL ++ 
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092

Query: 729  AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK--L 786
            A++EE+ ++       E+      L+   + L   I    E  D   +     E++K  L
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 787  KKELERLKDDL-GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDK 844
             +ELE LK +L  T+ +   +   +A     V  L+  L+   ++   QV  M   +   
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 845  LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH 904
            ++ +   L+  + A+A +   +  L +E A +A +      +  L Q + EV+ K++   
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQEVEHKKKKLE 1265

Query: 905  ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 964
            A   ELQ   +              D +  + + +  V + QN    +   L + EG  K
Sbjct: 1266 AQVQELQSKCS--------------DGERARAELNDKVHKLQNEVESVTGMLNEAEG--K 1309

Query: 965  SLKYYRDTYHPLDDWIQQVETTQRKIQEN--QPENSKTLATQLNQQK-----MLVSEIEM 1017
            ++K  +D    +     Q++ TQ  +QE   Q  N  T   QL +++      L  E+E 
Sbjct: 1310 AIKLAKD----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365

Query: 1018 KQS----------KMDECQKYAEQYSATV-----------KDYELQTMTYRAMVDSQQKS 1056
            KQ+          ++ + +K  + +++TV           K+ E  T  Y     +  K 
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425

Query: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116
               + R+Q   D ++   +DL  +   +  L  +  KF  D L   EE+ I         
Sbjct: 1426 EKTKNRLQQELDDLV---VDLDNQRQLVSNLEKKQRKF--DQLLA-EEKNIS-------- 1471

Query: 1117 GAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQ 1176
              Y+D   R +A   E       ++       E K++  R  + L    E   +      
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531

Query: 1177 RNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLL 1236
            +NV ++   K   E++ ++ + +LE +  E +A E   +   +L +  +A +   E +L 
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDL- 1587

Query: 1237 NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL-----I 1291
              + + E+N   RR L+  L   +  L D E+++  L    ++K + + + L+L     I
Sbjct: 1588 --QARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351
            K  E+ +  Q +  + Q+K+ Q+   +AR    EI  T +EN        +A S  A   
Sbjct: 1645 KGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENE------KKAKSLEADL- 1696

Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYEL---NALQLEKTSSEEKARLLKD 1408
            +Q + D   AE  ++Q D       + E+   EL   L   NALQ EK   E +   L++
Sbjct: 1697 MQLQEDLAAAERARKQAD------LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750

Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL---NQTTGKAEEAMQEASDLKKI 1465
            +L+E    +  +       D+  K  +QQ  +L  +L     T  K E A Q+     K 
Sbjct: 1751 ELEEEQGNMEAMS------DRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525
             R+   E+E     K K            A  E  I  L  Q+     EK        Q 
Sbjct: 1804 LRSKLHEMEGAVKSKFK---------STIAALEAKIAQLEEQVEQEAREK--------QA 1846

Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNE 1585
             +  LK++ +K  E LLQ     ++     ++  E+ EK N   + LK+++EE   ++  
Sbjct: 1847 ATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902

Query: 1586 TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG 1620
                 +++Q E +      + + +   ALK +  G
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 220/1120 (19%), Positives = 439/1120 (39%), Gaps = 192/1120 (17%)

Query: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323
            K   L++ L E E  ++  +D        Q+Q +R +    +  +E  LE  +   + ++
Sbjct: 923  KKQELEEILHEMEARLEEEEDR-----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

Query: 324  EFESSLKEAKISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQE---RHLDTLH 376
              E    EAKI +++    +      KL +    LE + + L      +E   ++L  L 
Sbjct: 978  -LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 377  NFVSRATNELIWLNEKEEE----------EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
            N      +EL    +KEE+          ++  D S+ +  IA  +   AEL  +L +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 427  ENIKSV-----QEIAEQ-------LLLENHPARL--TIEAYRAAMQTQWSWILQLCQCVE 472
            E +++       EIA++         LE H + L   +++ RAA          L + +E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156

Query: 473  ------QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526
                  +   ++TA  +     +E    +  LK A+  + +    + + ++     +++E
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALDEE-TRSHEAQVQEMRQKHAQAVE 1213

Query: 527  E-KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585
            E  E+L Q+K   ANL    +T   L+  N+D                         +  
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQT---LEKENAD----------------------LAGELR 1248

Query: 586  VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHI 645
            VL       + K          + S C        E  D  ++++ + ++V  + +E+  
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 646  NMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSG 705
                +              A +VAS+ + L               ++ L++    ++   
Sbjct: 1309 KAIKL--------------AKDVASLSSQLQDT------------QELLQEETRQKLNVS 1342

Query: 706  SDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLR--------LENCE 757
            + + QLE+E N  +    E +++ +  E+  S  N+ +S+ +  +L+        LE  +
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK-KLQDFASTVEALEEGK 1401

Query: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
             R  ++I    ++    E      + EK K  L++  DDL    +   +          V
Sbjct: 1402 KRFQKEIENLTQQ--YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---------V 1450

Query: 818  PTLRSELNVVLQNMNQVYSMSSTYID------------KLKTVNLVLKNTQAAEALVKLY 865
              L  +     Q + +  ++SS Y D            + K ++L     +A EA  +L 
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 866  ETK---LCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQVFHALEDELQKAK---- 914
             T      E E +++ K+    N+  L  + +   ++++E +     LEDELQ  +    
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570

Query: 915  --AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972
               ++ +  K   ERDL     + + +Q  E+ + +  Q+     +LE   K        
Sbjct: 1571 RLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625

Query: 973  YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY 1032
               L+  ++ +E       + + E  K L     Q K    E+E  ++  DE        
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE-------I 1678

Query: 1033 SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM-DLRTRYTALVTLMTQY 1091
             AT K+ E +  +  A +   Q+      R +  ADL  +E   +L +  +    L    
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ--- 1735

Query: 1092 IKFAGDSLKRLE------EEEIKRCKETSEHGAYSDLLQR--QKATVLENSKLTGKISEL 1143
                 D  +RLE      EEE++  +E     A SD +++  Q+A  L N   T      
Sbjct: 1736 -----DEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELAT------ 1782

Query: 1144 ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRA-ESEAKQYRRELET 1202
            ER  A+ K + +R  ++L +  +   ++L + +  V+      I A E++  Q   ++E 
Sbjct: 1783 ERSTAQ-KNESAR--QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 1203 IVREKEAAEREL----ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258
              REK+AA + L    ++++++ ++ E +R   E+    ++ Q E+     + L+  L+ 
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ----YKEQAEKGNARVKQLKRQLEE 1895

Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL 1298
             +     +   + KL  EL    ++ E + + +  ++  L
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 109/524 (20%), Positives = 217/524 (41%), Gaps = 80/524 (15%)

Query: 1541 LLQNIKAEKE---NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597
            LLQ  + E+E     D++Q+  E  +K+    + L+QK  +LT + N   L+ +++QAE+
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQEQLQAET 907

Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657
            E        +    E ++++    K +L    E LH+              LEE+  + Q
Sbjct: 908  E--------LYAEAEEMRVRLAAKKQEL---EEILHEMEAR----------LEEEEDRGQ 946

Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLK 1717
             L +E K+   Q                 +L    EE+    QK+QL++   +    ++K
Sbjct: 947  QLQAERKKMAQQM---------------LDLEEQLEEEEAARQKLQLEKVTAEA---KIK 988

Query: 1718 KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL 1777
            K++DE+ +   +     ++  L +E       +  E  +K + L + K   E+ IS +  
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE- 1047

Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDEL-- 1835
              V L++E    QE  KL     ++LE     + EQ+   Q   A    +  K E+EL  
Sbjct: 1048 --VRLKKEEKSRQELEKL----KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101

Query: 1836 --------IAQKREVENLKQKMDQQIKEHEHQL-----VLLQCEIQKKSTAKDC-TFKPD 1881
                    IAQK       ++++  I + +  L        + E QK+   ++    K +
Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161

Query: 1882 FEMTVKECQHSGELSSRNTGHLHPTPRS-PLLRWTQEPQPLEEKWQH-RVVEQIPKEV-Q 1938
             E T+       EL ++    +    ++      + E Q  E + +H + VE++ +++ Q
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 1939 FQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRL-----SEIEKIRDQALNNS 1993
            F+   A L+K K  Q   +  +  + EL++       +        +++++++ +  +  
Sbjct: 1222 FKRAKANLDKNK--QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279

Query: 1994 RPPVRYQDNACEM--ELVKVLTPLEIAKNKQYDMHTEVTTLKQE 2035
            R      D   ++  E+  V   L  A+ K   +  +V +L  +
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,199,211
Number of Sequences: 37866
Number of extensions: 4093044
Number of successful extensions: 46844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 528
Number of HSP's successfully gapped in prelim test: 1402
Number of HSP's that attempted gapping in prelim test: 15869
Number of HSP's gapped (non-prelim): 12932
length of query: 2649
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2530
effective length of database: 13,741,464
effective search space: 34765903920
effective search space used: 34765903920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.