BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4502443 dystonin isoform 1e precursor [Homo sapiens] (2649 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 5183 0.0 gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 2235 0.0 gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 2191 0.0 gi|221316624 dystonin isoform 4 [Homo sapiens] 2124 0.0 gi|221316622 dystonin isoform 3 [Homo sapiens] 2124 0.0 gi|221316618 dystonin isoform 2 [Homo sapiens] 2124 0.0 gi|34577047 dystonin isoform 1 [Homo sapiens] 2124 0.0 gi|33188445 microfilament and actin filament cross-linker protei... 1070 0.0 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 923 0.0 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 923 0.0 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 923 0.0 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 923 0.0 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 923 0.0 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 923 0.0 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 923 0.0 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 923 0.0 gi|58530840 desmoplakin isoform I [Homo sapiens] 858 0.0 gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 667 0.0 gi|58530842 desmoplakin isoform II [Homo sapiens] 606 e-172 gi|45439327 periplakin [Homo sapiens] 372 e-102 gi|156104874 envoplakin [Homo sapiens] 300 1e-80 gi|207452735 epiplakin 1 [Homo sapiens] 261 6e-69 gi|71061468 centromere protein E [Homo sapiens] 179 4e-44 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 171 1e-41 gi|148746195 trichohyalin [Homo sapiens] 161 9e-39 gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 159 5e-38 gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 158 6e-38 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 155 7e-37 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 155 7e-37 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 155 7e-37 >gi|4502443 dystonin isoform 1e precursor [Homo sapiens] Length = 2649 Score = 5183 bits (13444), Expect = 0.0 Identities = 2649/2649 (100%), Positives = 2649/2649 (100%) Query: 1 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML Sbjct: 1 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60 Query: 61 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI Sbjct: 61 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120 Query: 121 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL Sbjct: 121 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180 Query: 181 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN Sbjct: 181 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240 Query: 241 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE Sbjct: 241 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300 Query: 301 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK Sbjct: 301 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360 Query: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR Sbjct: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420 Query: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA Sbjct: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480 Query: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN Sbjct: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540 Query: 541 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS Sbjct: 541 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI Sbjct: 601 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660 Query: 661 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ Sbjct: 661 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720 Query: 721 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI Sbjct: 721 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780 Query: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST Sbjct: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840 Query: 841 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR Sbjct: 841 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900 Query: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE Sbjct: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960 Query: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS Sbjct: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020 Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080 Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI 1140 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI 1140 Query: 1141 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL Sbjct: 1141 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200 Query: 1201 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD 1260 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD Sbjct: 1201 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD 1260 Query: 1261 LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR 1320 LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR Sbjct: 1261 LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR 1320 Query: 1321 RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ 1380 RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ Sbjct: 1321 RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ 1380 Query: 1381 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE 1440 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE Sbjct: 1381 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE 1440 Query: 1441 LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN 1500 LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN Sbjct: 1441 LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN 1500 Query: 1501 IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE 1560 IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE Sbjct: 1501 IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE 1560 Query: 1561 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG 1620 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG Sbjct: 1561 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG 1620 Query: 1621 FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE 1680 FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE Sbjct: 1621 FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE 1680 Query: 1681 VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF 1740 VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF Sbjct: 1681 VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF 1740 Query: 1741 QEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI 1800 QEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI Sbjct: 1741 QEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI 1800 Query: 1801 KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860 KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL Sbjct: 1801 KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860 Query: 1861 VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP 1920 VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP Sbjct: 1861 VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP 1920 Query: 1921 LEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLS 1980 LEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLS Sbjct: 1921 LEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLS 1980 Query: 1981 EIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVP 2040 EIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVP Sbjct: 1981 EIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVP 2040 Query: 2041 SAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQ 2100 SAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQ Sbjct: 2041 SAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQ 2100 Query: 2101 LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERI 2160 LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERI Sbjct: 2101 LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERI 2160 Query: 2161 IIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSY 2220 IIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSY Sbjct: 2161 IIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSY 2220 Query: 2221 SSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQ 2280 SSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQ Sbjct: 2221 SSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQ 2280 Query: 2281 FLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRIS 2340 FLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRIS Sbjct: 2281 FLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRIS 2340 Query: 2341 VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH 2400 VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH Sbjct: 2341 VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH 2400 Query: 2401 FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERI 2460 FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERI Sbjct: 2401 FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERI 2460 Query: 2461 SVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQC 2520 SVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQC Sbjct: 2461 SVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQC 2520 Query: 2521 ELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEAL 2580 ELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEAL Sbjct: 2521 ELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEAL 2580 Query: 2581 QVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640 QVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT Sbjct: 2581 QVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640 Query: 2641 GISSLYYSS 2649 GISSLYYSS Sbjct: 2641 GISSLYYSS 2649 >gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] Length = 5171 Score = 2235 bits (5791), Expect = 0.0 Identities = 1280/2059 (62%), Positives = 1468/2059 (71%), Gaps = 172/2059 (8%) Query: 1 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML Sbjct: 1 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60 Query: 61 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI Sbjct: 61 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120 Query: 121 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL Sbjct: 121 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180 Query: 181 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN Sbjct: 181 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240 Query: 241 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE Sbjct: 241 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300 Query: 301 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK Sbjct: 301 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360 Query: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR Sbjct: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420 Query: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA Sbjct: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480 Query: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN Sbjct: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540 Query: 541 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS Sbjct: 541 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI Sbjct: 601 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660 Query: 661 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ Sbjct: 661 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720 Query: 721 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI Sbjct: 721 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780 Query: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST Sbjct: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840 Query: 841 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR Sbjct: 841 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900 Query: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE Sbjct: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960 Query: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS Sbjct: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020 Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080 Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LENSKLT 1137 YTALVTLMTQYIKFAGDSLKRLEEEE +E EH + LQ+ + + L++++ Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140 Query: 1138 GK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNVE---- 1180 GK S+ + E+ +K ++ E L K+ + NEL KQ + ++ Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1200 Query: 1181 -----------------DISLQKIRAESEAKQYRRELETI-------------------- 1203 D+ +++ ++Y+ +L+ I Sbjct: 1201 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1260 Query: 1204 ------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFTRRTLE 1253 +++ ++ + EL++ Q + +A A+ EN L +Q ++ ++ E Sbjct: 1261 GDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNE 1320 Query: 1254 DHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQ 1313 +K + L+L EQ K +L + + E E + +KQ+E+ K E L Sbjct: 1321 AKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENLLDWLS 1375 Query: 1314 KIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ---KA 1361 ++ ++ R T+ + +N Q ++ G L+ + D Q Sbjct: 1376 NVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1431 Query: 1362 EELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKLDETNN 1415 E L QQ ++ A + K + + + Q LEK S EEK +L K+ + E Sbjct: 1432 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKV 1490 Query: 1416 TLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK-----------K 1464 E E+K + ++L + + +++ QE +L+ K Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1550 Query: 1465 IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQ 1524 +KR + ++H KG L+ R A+ + ++ + +E+ Q Sbjct: 1551 LKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV------Q 1603 Query: 1525 RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNECAEML 1572 RK DH ++F + + K+ DK Q + E S +E + Sbjct: 1604 RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPI 1663 Query: 1573 KQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHL 1632 + L RQ ETK + +I S+ + +EK LK A+ D S Sbjct: 1664 AVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGSLLPAK 1712 Query: 1633 HKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASK 1692 + KT D + EDL+KS N +E Q +++ +Q+ E+ + + +S Sbjct: 1713 NDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL 1768 Query: 1693 EEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHR 1735 +E+ + EQ + +Q+ + +N ++KK ++T + Sbjct: 1769 KEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDPSTASS 1823 Query: 1736 KMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKL 1795 ++ S +F +++ + ++ + K+ E K E + + + ++A + Sbjct: 1824 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQALTEVDV 1882 Query: 1796 CETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 ++ EL + +Q+ E ++ +H+E H + L + K V + ++ K Sbjct: 1883 PGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFK 1942 Query: 1855 EHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-PRSPLL 1912 E E + +KK C + D F++ VK + + +++ + P+ L Sbjct: 1943 EMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 1996 Query: 1913 RWTQEPQPLEEKWQHRVVE 1931 + ++ + L+EKW + E Sbjct: 1997 KSLEDTKKLQEKWSLKTPE 2015 Score = 98.6 bits (244), Expect = 7e-20 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%) Query: 287 NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344 +W+ + + +L+ E G+D + + + L+ K+ + + L+ IS ++ K Sbjct: 1525 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1584 Query: 345 ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385 T+ E +L+ S Y+K N + +D ++ + Sbjct: 1585 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1644 Query: 386 LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438 L L E E +A D N+ R+ + L ++ ++ ++ +++ AE Sbjct: 1645 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 1700 Query: 439 LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490 LL AR ++ + +Q I+ + + + + E T + E Sbjct: 1701 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 1756 Query: 491 ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550 D++ N++ +++ + +S+ L+D++ +++ ++++ +S+I + K K ++ Sbjct: 1757 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 1814 Query: 551 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608 +D +S+ K + +K E + + K ++ + Sbjct: 1815 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 1870 Query: 609 ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665 V P K+ +L+ +++ L H+ H+ + H L+ EI + Sbjct: 1871 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 1920 Query: 666 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725 + S K ++ E LS ED +++ +E+ + + V K + +E Sbjct: 1921 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 1979 Query: 726 -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766 L+ ++ +++ S+ I +V N + L N LI + T Sbjct: 1980 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2035 Query: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826 P + +S + E GT TN EEF++ +S Sbjct: 2036 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2070 Query: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886 + ++M + S Y D + L+LK+ + AE KL + + +EE+ A ++ + Sbjct: 2071 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2121 Query: 887 STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932 T +W +++V++ + L+ + K + + D++ + +E + Sbjct: 2122 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2181 Query: 933 -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991 W K+ ++ +WQ ++ +R + LE +L ++ L W+ + E + Sbjct: 2182 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2239 Query: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050 + L TQ Q ++L+ E ++ + ++ + S +D L+ + + Sbjct: 2240 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2299 Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105 QK ++ D I Q + T+Y +L+ ++ + K + + Sbjct: 2300 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2358 Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162 + + ET++ +Q++K + L +S L E + AEL +Q + + Sbjct: 2359 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2416 Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222 V + AEN ++ Q + + +Q R+ + + K + E + ++ Sbjct: 2417 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2465 Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282 + + + ++++ + ++ +T+ + ++L L +K L +L + Sbjct: 2466 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2522 Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342 N + K +K+ E L K+ EK LK K+++E I + Q E + P Sbjct: 2523 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2578 Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389 S + LQ+E D+ E L + L T N+ Q + +T +L Sbjct: 2579 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2638 Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437 ++ + + +K + ++ E+ L+C K +L+ D + YS + Sbjct: 2639 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 2698 Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492 L+ L Q++ A++ + EASD K + L++E++ E L ++VD T+ Sbjct: 2699 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 2757 Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548 + + I+ + SQ F D EL+ + R ++ L++Q E K+ + L+ + A Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 2815 Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608 +N +K ++ E+++ +K+ +E L++Q N+ ++ R QA E + + TI Sbjct: 2816 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 2868 Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665 +R E + F L+ EH ++ Q + E + + N+ F++ Sbjct: 2869 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 2920 Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714 + QQ++ +IQ+ K + L +L+ + +KV + AQ+QE Sbjct: 2921 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 2980 Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772 + QD L T + + S +FK ++ + +K +++L++ + T I Sbjct: 2981 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3040 Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830 G ++ + + + + L ++ + L + + Q++ + ++ + Sbjct: 3041 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3100 Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857 L + L ++ + N + K+++QI +H+ Sbjct: 3101 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3133 Score = 82.4 bits (202), Expect = 5e-15 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%) Query: 707 DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762 D+ +++++ + +LL A+ REEQ E + S+++ + L+ E+ Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 2894 Query: 763 QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820 Q +E + +++ ++F++ ++E E+E L+ + + AA S+S L Sbjct: 2895 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950 Query: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880 +L+ V + + +L+ L Q +AL L + EE V K Sbjct: 2951 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3008 Query: 881 NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939 + K ++++ E++ + L+D + I E K + D ++ Sbjct: 3009 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3064 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990 L RW+ + + + R R LEGI + + +T PL++W+ +E TQ Sbjct: 3065 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3124 Query: 991 QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027 E Q K L A + Q ++S E M QSK+D E Q+ Sbjct: 3125 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3184 Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071 + S ++ + E++ M + V S Q + Q S ++ Sbjct: 3185 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3244 Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115 QE + LR + AL+ + + GD + +++ E IK R K+ ++ Sbjct: 3245 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3304 Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161 H + +L L + + +L E L G + S+ + ELKK+ + L Sbjct: 3305 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3364 Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221 + E + L + L+K+ AE + ++YR +TI ++ E + + R +Q Sbjct: 3365 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3422 Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271 A+A+ + + E+ L++ + E T L+ + L+ KD+ ++DL + + Sbjct: 3423 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3481 Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331 K+M +EEE + K+++K L + Q+ ++ ++LE + + + Sbjct: 3482 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3534 Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390 E P TQ+ S L+ E +Q+ EE +Q+ EL A ++ M + +L Sbjct: 3535 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3593 Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449 L + S ++ + D L + ++ + L+ + ++ ++ L + Sbjct: 3594 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3653 Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493 + + +++++KIK +N +++E L +E K + E D+ A Sbjct: 3654 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 3713 Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551 AV +K + + IH+ +E+E + L + + L E+F H L+ I K+ Sbjct: 3714 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 3765 Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603 D I+ L + +++ E AE ++++++ L + + L + I A E + + Sbjct: 3766 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 3825 Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650 K++I + A +KD++ E + + + Q + + Sbjct: 3826 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 3885 Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703 DL + + E KQ + Q + E N AEL K + + VQ Sbjct: 3886 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 3943 Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754 + + + + NR K++ L L + +TH + +L +++ A E Sbjct: 3944 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4003 Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808 ++++ V+ +G L S +E S Q ++ + + + + Sbjct: 4004 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4063 Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868 Q ++Q+ + + + L+ L +R + L K + E + + + E+ Sbjct: 4064 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4121 Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928 AK+ T+K L + L P+S Q+ L+EKW+ Sbjct: 4122 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4167 Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968 + ++ + + +E S Q + + +Q L + Sbjct: 4168 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4208 Score = 77.8 bits (190), Expect = 1e-13 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%) Query: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801 Y S +R++ +L + +++L + D +++ ++ +K+K+E+++ K + Sbjct: 2329 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2385 Query: 802 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857 CE+ + L +L +L++ V + ++ L++ + + ++ Sbjct: 2386 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2445 Query: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917 +A + + + + + A + +E+LI K + + + ++ K I+ Sbjct: 2446 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2496 Query: 918 DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976 + K + + + + + + W + Q+ R L E + K+LK Y++ L Sbjct: 2497 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2555 Query: 977 DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017 WI + + +I+ EN K+L +++Q L+S E+ Sbjct: 2556 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2615 Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070 K+ DE + ++ K + L+ MT + + Q+ S +R++Q + + L Sbjct: 2616 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 2674 Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124 I + + + +T++ Q +K D KRL ++ + E S+ SD+L Sbjct: 2675 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 2731 Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170 + + E+S L+ ++ E + + E+ Q + ++EL + + Sbjct: 2732 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 2791 Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229 E ++Q+ L+K+ A + + ++ E +L +++ +EA +K+ Sbjct: 2792 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 2850 Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289 + R + E T +R E + K K+ S + QK + EE + E E + Sbjct: 2851 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 2906 Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349 +Q+ FQK+ E ++Q + N L I A + Sbjct: 2907 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 2947 Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396 GL+ + D K+ A+ Q + L R + L++ ++ +L +K Sbjct: 2948 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3007 Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442 S E + +LL+ LD+ +T+ +K E E+ + A+K +QL L Sbjct: 3008 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3067 Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489 + KAE ++ + + + + LE LN EK G +++ Sbjct: 3068 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3127 Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537 H E +I + N +H S R++K++ + ++ + +++ Q EKS Sbjct: 3128 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3186 Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591 H +LLQ A+ D+++ +N E ++ +++ Q E L +Q +E +++ + Sbjct: 3187 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3246 Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646 I +N+ Q + E LK Q G +D+L + TK D Sbjct: 3247 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3299 Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705 K LE+ L ++ L S ++ C + ++ E + L E AS+ + R E K + + Sbjct: 3300 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3358 Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761 + L + L +V L L+ + + + E++ +++ ++ +K+E++ Sbjct: 3359 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3415 Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810 E ITE + + L + L+Q+ + AQ ++ +T E+ R Sbjct: 3416 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3473 Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 + ++ G + + E +++K+K+D+ +K ++ Sbjct: 3474 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3507 Score = 72.8 bits (177), Expect = 4e-12 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311 +S LL Q L +I + +L+NW++E+ +L + W S+L + E Sbjct: 3189 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3248 Query: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371 L +NV +A+ LK+ E+ L +KL ++++Y + S + + Sbjct: 3249 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3301 Query: 372 LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425 L+ R +T+E + WL++ E E ++Y+ T + + ++ MR EL ++ Sbjct: 3302 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3356 Query: 426 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485 +N K++ + L E A L + +RA + +E+ + E+ + Sbjct: 3357 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3400 Query: 486 NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542 +D T + + AI R D++ + + + + ++ M + L+ T A L + Sbjct: 3401 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3458 Query: 543 GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601 K T+ L+ ++ D +K+ I C + + K D+ VL N + I Sbjct: 3459 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3511 Query: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661 +E + + A L N+ + Y+ L W ++ S + L E Sbjct: 3512 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3561 Query: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718 R + ++ ++ EH+ + + LE S G + EK V + Sbjct: 3562 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3614 Query: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778 Q +++ K A ++ S + ++ I LE +RL + E + + E Sbjct: 3615 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3671 Query: 779 RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835 +I+E + + ++E+L+ T+ + EE +++ + S ++ +L+ ++ ++ Sbjct: 3672 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 3731 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886 ++ KL V ++L E C+ ++I + ++ I Sbjct: 3732 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 3778 Query: 887 -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945 S +KQ + + R+ L++EL + E+ E D K+ D+L W Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 3836 Query: 946 QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003 +++ +R+ LE ++ Y+D + DW V+ K+ P + +T+ Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 3893 Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057 Q+ + K SE +Q +M+ AE V + + M + + DS ++ Sbjct: 3894 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 3953 Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113 + R+ A L + +F A +T L+++ GD K +E E K Sbjct: 3954 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4007 Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173 H +D+L Q +TV +K + E + ++ S ++ +L + + +N L Sbjct: 4008 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4060 Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222 K ++ + + A +AK + E+E + + ER L QL + Sbjct: 4061 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4116 Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281 E AA E +++ +++ R + D +N+L+++ + +L ++ Sbjct: 4117 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4175 Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337 EE L L + +D AE+ L + L + +I ++ N + Sbjct: 4176 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4235 Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397 + T L+ KQ +K + + + K Q + E L+ + Sbjct: 4236 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4295 Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451 E L + L+E+ +L +LE+ K Q +E + L TT + Sbjct: 4296 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4354 Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511 +++E + L + L+L+ + E L+ + D I + ++ F Sbjct: 4355 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4407 Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571 D + + + + ++Q L+ N+ D + +EL K + Sbjct: 4408 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4461 Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 LK+ EL + + K+ MQ + E + + Q R EA QA+ F + + Sbjct: 4462 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4521 Query: 1628 TNEHLHKQTKT 1638 E L + +T Sbjct: 4522 LLEWLAEAEQT 4532 Score = 53.9 bits (128), Expect = 2e-06 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%) Query: 260 KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308 KP++K S+ + N + +N + +Q + + D +Q D + G L S+ Sbjct: 3822 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 3881 Query: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368 + + V + IEE + EA +I+M RL Q A+LL + Sbjct: 3882 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 3928 Query: 369 ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426 E T+ + + +LIW + EE + +A + HA EL+ L E Sbjct: 3929 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 3985 Query: 427 ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486 + +EQ + P + IE + H+ +N Sbjct: 3986 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4019 Query: 487 DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546 EA + N D I+ + S+ +KLE L Q E+ Q K + + +AK Sbjct: 4020 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4077 Query: 547 TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 +Q +++ L S P+ + + + ++ ++ E A + +K + Sbjct: 4078 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4135 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651 G + + P + +D N +++++++V T +E ++ + Sbjct: 4136 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4190 Query: 652 SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710 S IN + + + NVAS +++ + L E +VF+ + Sbjct: 4191 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4236 Query: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766 E+ + + K LK +++ + NL IS ++ R E RL+ + R+ Sbjct: 4237 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4290 Query: 767 PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817 HE+ ++ E ++ L ELE D + T + +EF A SV Sbjct: 4291 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4350 Query: 818 ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856 +L+ + ++ N+ ++ M S DK T+ ++ +N T Sbjct: 4351 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4409 Query: 857 AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913 A +AL+ LY E +L E++ V D + + NLI K ++ E+ ++ AL Sbjct: 4410 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4462 Query: 914 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973 K + E+ + ++ D W K + +L RW+ V ++ LE + + + Sbjct: 4463 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4519 Query: 974 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024 H L +W+ + E T R P++ L T ++Q K + ++E K++++++ Sbjct: 4520 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4569 Score = 40.8 bits (94), Expect = 0.018 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%) Query: 282 VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339 +Q L++W+ ++ QL D+ G D+ V + ++NHK + + + SS++ K S ++ Sbjct: 4411 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4469 Query: 340 -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392 ++ +K+ E R E+ A ++ E L F S L WL E Sbjct: 4470 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4529 Query: 393 EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449 E+ + + + R D H E M++L++K + + + +L HP +T Sbjct: 4530 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4589 Query: 450 ---IEAYRAAMQTQWSWILQ 466 I RA + +W Q Sbjct: 4590 KHWITIIRARFEEVLAWAKQ 4609 Score = 40.0 bits (92), Expect = 0.031 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%) Query: 242 SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294 S+G E ++LQ L+++ R K + LD L + + ++DL W+ + + Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095 Query: 295 QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351 L ++ LP + + L H V A E E + K QM A + + Sbjct: 4096 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4155 Query: 352 ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394 + ES KL E L+ F + + + WL + E+ Sbjct: 4156 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4215 Query: 395 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453 + V + E A + + H E + ELD+ ++K + + +L++N Sbjct: 4216 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4265 Query: 454 RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513 ++Q++W ++Q + VE+ R+L DA RK R+ Sbjct: 4266 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4296 Query: 514 IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572 H+ + E +EE E+ L + IAN K KT + Q K K S+ Sbjct: 4297 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4356 Query: 573 RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622 R + E T DD L + + R KW I EA++ S FT + Sbjct: 4357 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4414 Query: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682 +D R+E Q + + + M + + E+ + R S+V ++K Sbjct: 4415 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4463 Query: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742 + + E +DS +V +++ + V Q L++A R+ +E + Sbjct: 4464 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4515 Query: 743 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802 S V + L E L P + D L I + ++ K+LE + +L T Sbjct: 4516 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4572 Query: 803 KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862 + + S+ T++ + ++ +V + + + +L + L A + L+ Sbjct: 4573 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4628 Query: 863 KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922 + L E + DK+ + Q EV +E+ + + D++ K Sbjct: 4629 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 4683 Query: 923 TYKERDLD 930 TYK R D Sbjct: 4684 TYKRRAAD 4691 >gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] Length = 3062 Score = 2191 bits (5677), Expect = 0.0 Identities = 1136/1255 (90%), Positives = 1171/1255 (93%), Gaps = 18/1255 (1%) Query: 1 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML Sbjct: 1 MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML 60 Query: 61 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI Sbjct: 61 QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI 120 Query: 121 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL Sbjct: 121 DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL 180 Query: 181 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN Sbjct: 181 NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN 240 Query: 241 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE Sbjct: 241 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE 300 Query: 301 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK Sbjct: 301 WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK 360 Query: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR Sbjct: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420 Query: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA Sbjct: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480 Query: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN Sbjct: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN 540 Query: 541 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS Sbjct: 541 LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI Sbjct: 601 PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI 660 Query: 661 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ Sbjct: 661 DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ 720 Query: 721 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI Sbjct: 721 YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780 Query: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST Sbjct: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840 Query: 841 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR Sbjct: 841 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900 Query: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE Sbjct: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960 Query: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS Sbjct: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020 Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080 Query: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LENSKLT 1137 YTALVTLMTQYIKFAGDSLKRLEEEE +E EH + LQ+ + + L++++ Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140 Query: 1138 GK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNVEDISL 1184 GK S+ + E+ +K ++ E L K+ + NEL KQ + +++ S Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQE-SY 1199 Query: 1185 QKIRAESEAKQYRRELETIVREKEAAERELE-RVRQLTIEAEAKRAAVEENLLNF 1238 + +ES + + V+ +E ++ + + Q T E + AV L+++ Sbjct: 1200 NLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDY 1254 Score = 112 bits (281), Expect = 4e-24 Identities = 210/1066 (19%), Positives = 412/1066 (38%), Gaps = 216/1066 (20%) Query: 1650 EEDLAKSQNLVSEFKQKCDQQNII----IQNTKKEV---RNLNAELNASKEEKRRGEQKV 1702 ++ L+ Q+ +F + + + I +KEV + EL S E + + E Sbjct: 680 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739 Query: 1703 QLQQAQVQELNNRLKKVQD-------------ELH---LKTIEEQMTHRKMVLFQEESGK 1746 L ++V+ + RL+ +D +LH + E++ +++ +++ G Sbjct: 740 NLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGT 799 Query: 1747 FKQSAEEF-------------RKKMEKLMES--KVITENDISGIRLDFVSLQQENSRAQE 1791 EEF R ++ ++++ +V + + +L V+L +N++A E Sbjct: 800 ITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAE 859 Query: 1792 ------NAKLCE--------TNIKELERQLQQYREQMQQGQ---HMEANHYQKCQKLEDE 1834 KLCE NI+ L L+Q+R ++ + + H + QK + + DE Sbjct: 860 ALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 919 Query: 1835 LIAQKRE----VENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQ 1890 + +E + K+K DQ ++ ++ V + ++ D E K + Sbjct: 920 MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLR------------DLEGIGKSLK 967 Query: 1891 HSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIP------KEVQFQPPGA 1944 + R+T H PL W Q+ + + K Q E + + Sbjct: 968 YY-----RDTYH-------PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015 Query: 1945 PLEKEKSQQC--YSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPV--RYQ 2000 +++ K +C Y+E +S T + ++ + + ++ + + +S + + Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075 Query: 2001 DNACEME-LVKVLTP-LEIAKNKQYDMHTEVTTLKQEKNP-VPSAEEWMLEGCRASGGLK 2057 D LV ++T ++ A + + E +L++EK V A+E S LK Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135 Query: 2058 KGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRL 2117 + K G P + Q + + ++ L + QL AK D T E+ Sbjct: 1136 DAE--KAGKPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKHGDKMTDEERNE 1187 Query: 2118 GLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 K V+ +Q++ N L+ ES K+ ++ + + +K+ Sbjct: 1188 LEKQVKTLQESYNL----------LFSESLKQLQESQTSGDVKVEEKL------------ 1225 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSVFQAMENRMLD 2237 D V+ G +D + + LSVFQA+ ++D Sbjct: 1226 ---------------DKVIAGTIDQT-----------------TGEVLSVFQAVLRGLID 1253 Query: 2238 RQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNN 2297 G +LE Q+ G+I P + A GL++ IL L E S Sbjct: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKA--------- 1304 Query: 2298 KQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 K+ + + + V D +Q + + + + S+V TG +LT+ +AFQ Sbjct: 1305 KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTG---SLVIPATGEQLTLQKAFQ 1361 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL- 2416 +NL+ +++ ++ +Q K+ L D T ++ + +++ T+ + Sbjct: 1362 QNLVSSALFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTLQENTG 1408 Query: 2417 -----VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLV 2471 V+ + G ITL G IS+L+A+ L+ Sbjct: 1409 MWLLPVRPQEGGRITLK---------------------------CGRNISILRAAHEGLI 1441 Query: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531 DR T R L AQ+ +GG+I+ +G++ V EA+ G++D A + ++ GI Sbjct: 1442 DRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSN 1501 Query: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591 K ++V EAV ++I + LE Q GLI P +LQ +I +A Sbjct: 1502 PAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAY 1561 Query: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEP 2637 K+ + + + + P++ + + A + D +T L ++ P Sbjct: 1562 KILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLP 1607 Score = 86.7 bits (213), Expect = 3e-16 Identities = 253/1280 (19%), Positives = 504/1280 (39%), Gaps = 225/1280 (17%) Query: 1140 ISELERMVAELKKQKSRVE--EELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYR 1197 + +L V E++ Q R E +LP V EN + R +E Sbjct: 282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENH-KNVHRAIE----------------- 323 Query: 1198 RELETIVREKEAAERELERVRQLTIEAEAKRAAVE-ENLLNFRNQLEENTFTRRTLEDHL 1256 E E+ ++E + +E ++ +LT + R + LLN E + T Sbjct: 324 -EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 382 Query: 1257 KRKDLSLNDLEQQK-----NKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKE 1311 + + LN+ E+++ ++ + RK+D EL++ + Q E+++ +++AE+ L E Sbjct: 383 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 442 Query: 1312 KQ--KIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVD 1369 ++ +EA R + Q++ L +C + + +D ++A + + + Sbjct: 443 NHPARLTIEAYRAAMQTQWSW---ILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLK 499 Query: 1370 ELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN-----NTLRCLKLEL 1424 + A RK D ++L L E S EEK LL+ K N T+ LK Sbjct: 500 D--AIQRKYSCDRSSSIHKLEDLVQE--SMEEKEELLQYKSTIANLMGKAKTIIQLK--- 552 Query: 1425 ERKDQAEKGYSQQLREL--GRQLNQTTGKAEEAM-------------------------- 1456 R S ++ + RQ+ T K +E + Sbjct: 553 PRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVC 612 Query: 1457 -------QEASDL-KKIKRNYQ--LELESLNHEKGK-------LQREVDRITRAHAVAEK 1499 +EA DL +I++ YQ L L +H K L E+DRI ++ + K Sbjct: 613 FTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIK 672 Query: 1500 ------------NIQ---------HLNSQIHSFRDEKELER-LQICQRKSDHLKEQFEKS 1537 N+Q SQ+ S D +LE+ + +C++ L + E+ Sbjct: 673 TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAERE 732 Query: 1538 HEQ---------LLQNIKAEKENNDK--IQRLNEELEKSNECAEMLKQKVEELTRQNNET 1586 ++ ++NI+ EN + I+++ LE+ + L + V +T Q Sbjct: 733 EQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD-----LHESVFRITEQ---- 783 Query: 1587 KLMMQRIQAESENIVLEKQTIQQRCEALKIQADG------FKDQLRSTNEHLHKQTKTEQ 1640 ++++ E E + + TI +CE QA + +L +++++ Sbjct: 784 ----EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 839 Query: 1641 DFQRKIKCLEEDLAKSQ---NLVSEFKQK-CDQQNIIIQNTKKEVRNLNAELNASKEEKR 1696 + K+K + L +Q LV ++ K C+++ +I K + NL ++ K+ + Sbjct: 840 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIAD--KNNIENL---ISTLKQWRS 894 Query: 1697 RGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRK 1756 ++K Q+ A EL + K + DE+ KT ++E F E+ + Sbjct: 895 EVDEKRQVFHALEDEL-QKAKAISDEM-FKT------------YKERDLDFDWHKEKADQ 940 Query: 1757 KMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816 +E+ V +N + D + + ++ + I+++E ++ +E + Sbjct: 941 LVERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 996 Query: 1817 GQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQ---QIKEHEHQLVLLQCEI--QKKS 1871 A + + L E+ ++ +++ ++ +Q +K++E Q + + + Q+KS Sbjct: 997 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1056 Query: 1872 TAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPR------SPLLRWTQEPQPLEE-- 1923 K + ++ ++E +L +R T + + L R +E + LEE Sbjct: 1057 PVKRRRMQSSADLIIQEFM---DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK 1113 Query: 1924 -----------KWQHRVVEQIPKEVQFQPPGAPLEKEK-SQQCYSEYFSQTSTELQITFD 1971 KW + + + + P P K+K S + S Q S LQ Sbjct: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKP--PFSKQKISSEEISTKKEQLSEALQ---- 1167 Query: 1972 ETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTE--- 2028 T + +K+ D+ N V+ + + + L L+ ++ D+ E Sbjct: 1168 -TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKL 1225 Query: 2029 ----VTTLKQEKNPVPSAEEWMLEGC---RASGGLKKGDFLKKGL-EPETFQNFDGDHAC 2080 T+ Q V S + +L G L + + GL PE + FD A Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285 Query: 2081 S--VRDDEFKFQGLRHTVTARQLVE-AKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKAT 2137 S + D++ Q L+ A++++ A + ++ L + T K L L Sbjct: 1286 SHGLIDEQILCQ-LKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILL---- 1340 Query: 2138 SIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLK 2197 S L + +T E+++ A ++ ++ + LE Q +IDP + + S+ D V + Sbjct: 1341 STGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQR 1400 Query: 2198 GVVDPEFRIRLLEAEKAAVG--YSYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVI 2255 + + LL G + +S+ +A ++DR+ +L AQ+ SGG+I Sbjct: 1401 STLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLI 1460 Query: 2256 DPVRGIRVPPEIALQQGLLN 2275 + G R+ E A+++G+++ Sbjct: 1461 NSNSGQRMTVEEAVREGVID 1480 Score = 57.8 bits (138), Expect = 1e-07 Identities = 152/889 (17%), Positives = 342/889 (38%), Gaps = 136/889 (15%) Query: 630 EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 688 E++ + V W E + N+ +H L+ E+D+ + N+ S++ + Q +L N + Sbjct: 391 EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446 Query: 689 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 748 R + + + TQ + +C+ E+ +E + Y + ++ + Sbjct: 447 RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490 Query: 749 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 808 L N +D + R+ +H+ + E + K+EL + K + + K + Sbjct: 491 ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549 Query: 809 SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858 +S P S ++ + + ++ ++++ K K ++ Sbjct: 550 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604 Query: 859 EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 914 EA+V + +EAV + + L W S ++ K V +H L +E+ + + Sbjct: 605 EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664 Query: 915 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 970 A + KT + H++ L R+++ D+ + K + + Sbjct: 665 ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719 Query: 971 DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1029 Y L +++ +R+ QE N + +SE+ + +++ C+ + Sbjct: 720 QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761 Query: 1030 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMD---------- 1076 Q ++ +L +R + Q+K + R++ I +EF Sbjct: 762 RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819 Query: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKL 1136 LR+ ++ M Q + + +L+ + K T A L++ + + E + Sbjct: 820 LRSELNVVLQNMNQVYSMSSTYIDKLKTVNLV-LKNTQ---AAEALVKLYETKLCEEEAV 875 Query: 1137 TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQY 1196 + +E +++ LK+ +S V+E+ +V A E+EL+K K ++ K Y Sbjct: 876 IADKNNIENLISTLKQWRSEVDEKR-QVFHALEDELQKA----------KAISDEMFKTY 924 Query: 1197 RRELETIVREKEAAERELERVRQLTIEAEAKRAAVE---ENLLNFRNQ-------LEENT 1246 + KE A++ +ER + + ++ + + +E ++L +R+ +++ Sbjct: 925 KERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE 984 Query: 1247 FTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQME---KDLAFQKQ 1303 T+R ++++ +L Q+ L+ E+ K+ +E K +Q KD Q Sbjct: 985 TTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTM 1044 Query: 1304 VAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEE 1363 + +QK ++ RR + +E + T A+ L ++ K + Sbjct: 1045 TYRAMVDSQQKSPVKRRRMQSSADLIIQEF------MDLRTRYTALVTLMTQYIKFAGDS 1098 Query: 1364 LKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLE 1423 LK+ L E +L+ EK EKA+ L+ + + TL+ + Sbjct: 1099 LKR------------------LEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKA 1140 Query: 1424 LERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLE 1472 + +K S+++ QL++ + + + D + +LE Sbjct: 1141 GKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELE 1189 Score = 50.4 bits (119), Expect = 2e-05 Identities = 203/1029 (19%), Positives = 397/1029 (38%), Gaps = 178/1029 (17%) Query: 705 GSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN---IRL-------RLE 754 GSD+ +E + K ++ + EE E S+ ISE++ ++L RLE Sbjct: 302 GSDLPSVESHLENHKNVHRAI------EEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355 Query: 755 NCEDRLIRQIRTPLER-DDLHESVFRITEQ-----EKLKKELERLKDDLGTITNKCEEFF 808 + +L+ R D LH V R T + EK ++E+ + T + +++ Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415 Query: 809 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 868 ++ L EL+ +N+ V ++ + + L ++ +AA + + Sbjct: 416 AE---------LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 466 Query: 869 LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928 LC+ +++ EN + ++ ++ E L+D +Q+ K D +K D Sbjct: 467 LCQ----CVEQHIKEN--TAYFEFFNDAKEATDYLRNLKDAIQR-KYSCDRSSSIHKLED 519 Query: 929 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988 L + +EK + L Q + + +L G K+ Sbjct: 520 LVQESMEEKEELL---------QYKSTIANLMGKAKT----------------------- 547 Query: 989 KIQENQPENSKT-LATQLNQQKML-VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY 1046 I + +P NS L T + + + +IE+ K DEC + A K + Sbjct: 548 -IIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK--VISPTGN 604 Query: 1047 RAMVDSQQKS-PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK--FAGDSLKRLE 1103 AMV S + P + A+ I Q++ ++ T + M + + + + R+ Sbjct: 605 EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664 Query: 1104 EEEIKRCKET--SEHGAYSDLLQRQKATVLENSKLT-----GKISELERMV-------AE 1149 + K EH LQ + LE+S+ + I++LE+ V E Sbjct: 665 ASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE 724 Query: 1150 LKKQKSRVEEE--LPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREK 1207 L K R E+E + + + +R + N ED +++IR E + I E+ Sbjct: 725 LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRIT-EQ 783 Query: 1208 EAAERELERVRQ----LTIEAEA--KRAAVEENLLNFRNQLE-------ENTFTRRTLED 1254 E ++ELER++ +T + E +AA ++ R++L + T D Sbjct: 784 EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843 Query: 1255 HLKRKDLSLNDLEQQK-------NKLMEE--LRRKRDNEEELLKLIKQMEKDLAFQKQVA 1305 LK +L L + + + KL EE + ++N E L+ +KQ ++ ++QV Sbjct: 844 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 903 Query: 1306 EKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELK 1365 E QK A+ E+ T +E L + K+KA++L Sbjct: 904 HALEDELQK----AKAISDEMFKTYKERDLDF-----------------DWHKEKADQL- 941 Query: 1366 QQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELE 1425 V+ + + + +R+L +L+ + + L D + + T R ++ E Sbjct: 942 --VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHP----LDDWIQQVETTQRKIQ---E 992 Query: 1426 RKDQAEKGYSQQLRE---LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGK 1482 + + K + QL + L ++ K +E + A ++Y+L+ + Sbjct: 993 NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDS 1052 Query: 1483 LQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLL 1542 Q+ + R + A+ IQ F D + + L Q+ K L Sbjct: 1053 QQKSPVKRRRMQSSADLIIQE-------FMDLRTRYTALVT------LMTQYIKFAGDSL 1099 Query: 1543 QNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVL 1602 + ++ E+++ ++ ++ E +EK+ E + + + L K + + SE I Sbjct: 1100 KRLEEEEKSLEEEKK--EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST 1157 Query: 1603 EKQTIQQRCEALKI----QADGFKDQLRSTNEHLHKQTKTEQD-----FQRKIKCLEEDL 1653 +K+ + + + +++ D D+ R+ L KQ KT Q+ F +K L+E Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERN---ELEKQVKTLQESYNLLFSESLKQLQESQ 1214 Query: 1654 AKSQNLVSE 1662 V E Sbjct: 1215 TSGDVKVEE 1223 >gi|221316624 dystonin isoform 4 [Homo sapiens] Length = 5526 Score = 2124 bits (5504), Expect = 0.0 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL Sbjct: 411 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 470 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG Sbjct: 471 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 530 Query: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS Sbjct: 531 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 590 Query: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ Sbjct: 591 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 650 Query: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE Sbjct: 651 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 710 Query: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH Sbjct: 711 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 770 Query: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI Sbjct: 771 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 830 Query: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK Sbjct: 831 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 890 Query: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK Sbjct: 891 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 950 Query: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY Sbjct: 951 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1010 Query: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV Sbjct: 1011 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1070 Query: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE Sbjct: 1071 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1130 Query: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY Sbjct: 1131 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1190 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1250 Query: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR Sbjct: 1251 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1310 Query: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI Sbjct: 1311 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1370 Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM Sbjct: 1371 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1430 Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE +E EH + LQ+ + + L+ Sbjct: 1431 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1490 Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179 +++ GK S+ + E+ +K ++ E L K+ + NEL KQ + + Sbjct: 1491 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1550 Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203 + D+ +++ ++Y+ +L+ I Sbjct: 1551 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1610 Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248 +++ ++ + EL++ Q + +A A+ EN L +Q ++ Sbjct: 1611 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1670 Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308 ++ E +K + L+L EQ K +L + + E E + +KQ+E+ K E Sbjct: 1671 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1725 Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359 L ++ ++ R T+ + +N Q ++ G L+ + D Q Sbjct: 1726 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1781 Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410 E L QQ ++ A + K + + + Q LEK S EEK +L K+ + Sbjct: 1782 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1840 Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463 E E E+K + ++L + + +++ QE +L+ Sbjct: 1841 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1900 Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519 K+KR + ++H KG L+ R A+ + ++ + +E+ Sbjct: 1901 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 1957 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567 QRK DH ++F + + K+ DK Q + E S Sbjct: 1958 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2013 Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 +E + + L RQ ETK + +I S+ + +EK LK A+ D S Sbjct: 2014 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2062 Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687 + KT D + EDL+KS N +E Q +++ +Q+ E+ + Sbjct: 2063 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2118 Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730 + +S +E+ + EQ + +Q+ + +N ++KK ++T + Sbjct: 2119 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2173 Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790 ++ S +F +++ + ++ + K+ E K E + + + ++A Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2232 Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849 + ++ EL + +Q+ E ++ +H+E H + L + K V + Sbjct: 2233 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2292 Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907 ++ KE E + +KK C + D F++ VK + + +++ + P+ Sbjct: 2293 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2346 Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931 L + ++ + L+EKW + E Sbjct: 2347 AEDLGKSLEDTKKLQEKWSLKTPE 2370 Score = 98.6 bits (244), Expect = 7e-20 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%) Query: 287 NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344 +W+ + + +L+ E G+D + + + L+ K+ + + L+ IS ++ K Sbjct: 1880 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1939 Query: 345 ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385 T+ E +L+ S Y+K N + +D ++ + Sbjct: 1940 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1999 Query: 386 LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438 L L E E +A D N+ R+ + L ++ ++ ++ +++ AE Sbjct: 2000 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2055 Query: 439 LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490 LL AR ++ + +Q I+ + + + + E T + E Sbjct: 2056 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2111 Query: 491 ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550 D++ N++ +++ + +S+ L+D++ +++ ++++ +S+I + K K ++ Sbjct: 2112 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2169 Query: 551 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608 +D +S+ K + +K E + + K ++ + Sbjct: 2170 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2225 Query: 609 ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665 V P K+ +L+ +++ L H+ H+ + H L+ EI + Sbjct: 2226 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2275 Query: 666 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725 + S K ++ E LS ED +++ +E+ + + V K + +E Sbjct: 2276 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2334 Query: 726 -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766 L+ ++ +++ S+ I +V N + L N LI + T Sbjct: 2335 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2390 Query: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826 P + +S + E GT TN EEF++ +S Sbjct: 2391 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2425 Query: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886 + ++M + S Y D + L+LK+ + AE KL + + +EE+ A ++ + Sbjct: 2426 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2476 Query: 887 STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932 T +W +++V++ + L+ + K + + D++ + +E + Sbjct: 2477 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2536 Query: 933 -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991 W K+ ++ +WQ ++ +R + LE +L ++ L W+ + E + Sbjct: 2537 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2594 Query: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050 + L TQ Q ++L+ E ++ + ++ + S +D L+ + + Sbjct: 2595 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2654 Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105 QK ++ D I Q + T+Y +L+ ++ + K + + Sbjct: 2655 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2713 Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162 + + ET++ +Q++K + L +S L E + AEL +Q + + Sbjct: 2714 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2771 Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222 V + AEN ++ Q + + +Q R+ + + K + E + ++ Sbjct: 2772 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2820 Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282 + + + ++++ + ++ +T+ + ++L L +K L +L + Sbjct: 2821 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2877 Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342 N + K +K+ E L K+ EK LK K+++E I + Q E + P Sbjct: 2878 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2933 Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389 S + LQ+E D+ E L + L T N+ Q + +T +L Sbjct: 2934 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2993 Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437 ++ + + +K + ++ E+ L+C K +L+ D + YS + Sbjct: 2994 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3053 Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492 L+ L Q++ A++ + EASD K + L++E++ E L ++VD T+ Sbjct: 3054 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3112 Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548 + + I+ + SQ F D EL+ + R ++ L++Q E K+ + L+ + A Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3170 Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608 +N +K ++ E+++ +K+ +E L++Q N+ ++ R QA E + + TI Sbjct: 3171 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3223 Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665 +R E + F L+ EH ++ Q + E + + N+ F++ Sbjct: 3224 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3275 Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714 + QQ++ +IQ+ K + L +L+ + +KV + AQ+QE Sbjct: 3276 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3335 Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772 + QD L T + + S +FK ++ + +K +++L++ + T I Sbjct: 3336 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3395 Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830 G ++ + + + + L ++ + L + + Q++ + ++ + Sbjct: 3396 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3455 Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857 L + L ++ + N + K+++QI +H+ Sbjct: 3456 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3488 Score = 82.4 bits (202), Expect = 5e-15 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%) Query: 707 DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762 D+ +++++ + +LL A+ REEQ E + S+++ + L+ E+ Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3249 Query: 763 QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820 Q +E + +++ ++F++ ++E E+E L+ + + AA S+S L Sbjct: 3250 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305 Query: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880 +L+ V + + +L+ L Q +AL L + EE V K Sbjct: 3306 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3363 Query: 881 NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939 + K ++++ E++ + L+D + I E K + D ++ Sbjct: 3364 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3419 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990 L RW+ + + + R R LEGI + + +T PL++W+ +E TQ Sbjct: 3420 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3479 Query: 991 QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027 E Q K L A + Q ++S E M QSK+D E Q+ Sbjct: 3480 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539 Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071 + S ++ + E++ M + V S Q + Q S ++ Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3599 Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115 QE + LR + AL+ + + GD + +++ E IK R K+ ++ Sbjct: 3600 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3659 Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161 H + +L L + + +L E L G + S+ + ELKK+ + L Sbjct: 3660 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3719 Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221 + E + L + L+K+ AE + ++YR +TI ++ E + + R +Q Sbjct: 3720 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3777 Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271 A+A+ + + E+ L++ + E T L+ + L+ KD+ ++DL + + Sbjct: 3778 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3836 Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331 K+M +EEE + K+++K L + Q+ ++ ++LE + + + Sbjct: 3837 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3889 Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390 E P TQ+ S L+ E +Q+ EE +Q+ EL A ++ M + +L Sbjct: 3890 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3948 Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449 L + S ++ + D L + ++ + L+ + ++ ++ L + Sbjct: 3949 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4008 Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493 + + +++++KIK +N +++E L +E K + E D+ A Sbjct: 4009 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4068 Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551 AV +K + + IH+ +E+E + L + + L E+F H L+ I K+ Sbjct: 4069 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4120 Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603 D I+ L + +++ E AE ++++++ L + + L + I A E + + Sbjct: 4121 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4180 Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650 K++I + A +KD++ E + + + Q + + Sbjct: 4181 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4240 Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703 DL + + E KQ + Q + E N AEL K + + VQ Sbjct: 4241 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4298 Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754 + + + + NR K++ L L + +TH + +L +++ A E Sbjct: 4299 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4358 Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808 ++++ V+ +G L S +E S Q ++ + + + + Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418 Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868 Q ++Q+ + + + L+ L +R + L K + E + + + E+ Sbjct: 4419 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4476 Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928 AK+ T+K L + L P+S Q+ L+EKW+ Sbjct: 4477 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4522 Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968 + ++ + + +E S Q + + +Q L + Sbjct: 4523 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4563 Score = 77.8 bits (190), Expect = 1e-13 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%) Query: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801 Y S +R++ +L + +++L + D +++ ++ +K+K+E+++ K + Sbjct: 2684 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2740 Query: 802 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857 CE+ + L +L +L++ V + ++ L++ + + ++ Sbjct: 2741 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2800 Query: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917 +A + + + + + A + +E+LI K + + + ++ K I+ Sbjct: 2801 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2851 Query: 918 DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976 + K + + + + + + W + Q+ R L E + K+LK Y++ L Sbjct: 2852 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2910 Query: 977 DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017 WI + + +I+ EN K+L +++Q L+S E+ Sbjct: 2911 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2970 Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070 K+ DE + ++ K + L+ MT + + Q+ S +R++Q + + L Sbjct: 2971 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3029 Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124 I + + + +T++ Q +K D KRL ++ + E S+ SD+L Sbjct: 3030 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3086 Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170 + + E+S L+ ++ E + + E+ Q + ++EL + + Sbjct: 3087 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3146 Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229 E ++Q+ L+K+ A + + ++ E +L +++ +EA +K+ Sbjct: 3147 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3205 Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289 + R + E T +R E + K K+ S + QK + EE + E E + Sbjct: 3206 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3261 Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349 +Q+ FQK+ E ++Q + N L I A + Sbjct: 3262 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3302 Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396 GL+ + D K+ A+ Q + L R + L++ ++ +L +K Sbjct: 3303 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3362 Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442 S E + +LL+ LD+ +T+ +K E E+ + A+K +QL L Sbjct: 3363 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3422 Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489 + KAE ++ + + + + LE LN EK G +++ Sbjct: 3423 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3482 Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537 H E +I + N +H S R++K++ + ++ + +++ Q EKS Sbjct: 3483 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3541 Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591 H +LLQ A+ D+++ +N E ++ +++ Q E L +Q +E +++ + Sbjct: 3542 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3601 Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646 I +N+ Q + E LK Q G +D+L + TK D Sbjct: 3602 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3654 Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705 K LE+ L ++ L S ++ C + ++ E + L E AS+ + R E K + + Sbjct: 3655 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3713 Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761 + L + L +V L L+ + + + E++ +++ ++ +K+E++ Sbjct: 3714 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3770 Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810 E ITE + + L + L+Q+ + AQ ++ +T E+ R Sbjct: 3771 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3828 Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 + ++ G + + E +++K+K+D+ +K ++ Sbjct: 3829 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3862 Score = 72.8 bits (177), Expect = 4e-12 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311 +S LL Q L +I + +L+NW++E+ +L + W S+L + E Sbjct: 3544 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3603 Query: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371 L +NV +A+ LK+ E+ L +KL ++++Y + S + + Sbjct: 3604 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3656 Query: 372 LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425 L+ R +T+E + WL++ E E ++Y+ T + + ++ MR EL ++ Sbjct: 3657 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3711 Query: 426 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485 +N K++ + L E A L + +RA + +E+ + E+ + Sbjct: 3712 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3755 Query: 486 NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542 +D T + + AI R D++ + + + + ++ M + L+ T A L + Sbjct: 3756 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3813 Query: 543 GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601 K T+ L+ ++ D +K+ I C + + K D+ VL N + I Sbjct: 3814 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3866 Query: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661 +E + + A L N+ + Y+ L W ++ S + L E Sbjct: 3867 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3916 Query: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718 R + ++ ++ EH+ + + LE S G + EK V + Sbjct: 3917 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3969 Query: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778 Q +++ K A ++ S + ++ I LE +RL + E + + E Sbjct: 3970 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4026 Query: 779 RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835 +I+E + + ++E+L+ T+ + EE +++ + S ++ +L+ ++ ++ Sbjct: 4027 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4086 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886 ++ KL V ++L E C+ ++I + ++ I Sbjct: 4087 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4133 Query: 887 -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945 S +KQ + + R+ L++EL + E+ E D K+ D+L W Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4191 Query: 946 QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003 +++ +R+ LE ++ Y+D + DW V+ K+ P + +T+ Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4248 Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057 Q+ + K SE +Q +M+ AE V + + M + + DS ++ Sbjct: 4249 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4308 Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113 + R+ A L + +F A +T L+++ GD K +E E K Sbjct: 4309 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4362 Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173 H +D+L Q +TV +K + E + ++ S ++ +L + + +N L Sbjct: 4363 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4415 Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222 K ++ + + A +AK + E+E + + ER L QL + Sbjct: 4416 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4471 Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281 E AA E +++ +++ R + D +N+L+++ + +L ++ Sbjct: 4472 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4530 Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337 EE L L + +D AE+ L + L + +I ++ N + Sbjct: 4531 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4590 Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397 + T L+ KQ +K + + + K Q + E L+ + Sbjct: 4591 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4650 Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451 E L + L+E+ +L +LE+ K Q +E + L TT + Sbjct: 4651 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4709 Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511 +++E + L + L+L+ + E L+ + D I + ++ F Sbjct: 4710 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4762 Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571 D + + + + ++Q L+ N+ D + +EL K + Sbjct: 4763 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4816 Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 LK+ EL + + K+ MQ + E + + Q R EA QA+ F + + Sbjct: 4817 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4876 Query: 1628 TNEHLHKQTKT 1638 E L + +T Sbjct: 4877 LLEWLAEAEQT 4887 Score = 53.9 bits (128), Expect = 2e-06 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%) Query: 260 KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308 KP++K S+ + N + +N + +Q + + D +Q D + G L S+ Sbjct: 4177 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4236 Query: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368 + + V + IEE + EA +I+M RL Q A+LL + Sbjct: 4237 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4283 Query: 369 ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426 E T+ + + +LIW + EE + +A + HA EL+ L E Sbjct: 4284 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4340 Query: 427 ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486 + +EQ + P + IE + H+ +N Sbjct: 4341 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4374 Query: 487 DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546 EA + N D I+ + S+ +KLE L Q E+ Q K + + +AK Sbjct: 4375 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4432 Query: 547 TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 +Q +++ L S P+ + + + ++ ++ E A + +K + Sbjct: 4433 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4490 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651 G + + P + +D N +++++++V T +E ++ + Sbjct: 4491 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4545 Query: 652 SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710 S IN + + + NVAS +++ + L E +VF+ + Sbjct: 4546 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4591 Query: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766 E+ + + K LK +++ + NL IS ++ R E RL+ + R+ Sbjct: 4592 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4645 Query: 767 PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817 HE+ ++ E ++ L ELE D + T + +EF A SV Sbjct: 4646 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4705 Query: 818 ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856 +L+ + ++ N+ ++ M S DK T+ ++ +N T Sbjct: 4706 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4764 Query: 857 AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913 A +AL+ LY E +L E++ V D + + NLI K ++ E+ ++ AL Sbjct: 4765 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4817 Query: 914 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973 K + E+ + ++ D W K + +L RW+ V ++ LE + + + Sbjct: 4818 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4874 Query: 974 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024 H L +W+ + E T R P++ L T ++Q K + ++E K++++++ Sbjct: 4875 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4924 Score = 40.8 bits (94), Expect = 0.018 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%) Query: 282 VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339 +Q L++W+ ++ QL D+ G D+ V + ++NHK + + + SS++ K S ++ Sbjct: 4766 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4824 Query: 340 -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392 ++ +K+ E R E+ A ++ E L F S L WL E Sbjct: 4825 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4884 Query: 393 EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449 E+ + + + R D H E M++L++K + + + +L HP +T Sbjct: 4885 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944 Query: 450 ---IEAYRAAMQTQWSWILQ 466 I RA + +W Q Sbjct: 4945 KHWITIIRARFEEVLAWAKQ 4964 Score = 40.0 bits (92), Expect = 0.031 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%) Query: 242 SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294 S+G E ++LQ L+++ R K + LD L + + ++DL W+ + + Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450 Query: 295 QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351 L ++ LP + + L H V A E E + K QM A + + Sbjct: 4451 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4510 Query: 352 ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394 + ES KL E L+ F + + + WL + E+ Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570 Query: 395 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453 + V + E A + + H E + ELD+ ++K + + +L++N Sbjct: 4571 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4620 Query: 454 RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513 ++Q++W ++Q + VE+ R+L DA RK R+ Sbjct: 4621 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4651 Query: 514 IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572 H+ + E +EE E+ L + IAN K KT + Q K K S+ Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711 Query: 573 RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622 R + E T DD L + + R KW I EA++ S FT + Sbjct: 4712 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4769 Query: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682 +D R+E Q + + + M + + E+ + R S+V ++K Sbjct: 4770 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4818 Query: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742 + + E +DS +V +++ + V Q L++A R+ +E + Sbjct: 4819 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4870 Query: 743 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802 S V + L E L P + D L I + ++ K+LE + +L T Sbjct: 4871 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4927 Query: 803 KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862 + + S+ T++ + ++ +V + + + +L + L A + L+ Sbjct: 4928 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4983 Query: 863 KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922 + L E + DK+ + Q EV +E+ + + D++ K Sbjct: 4984 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5038 Query: 923 TYKERDLD 930 TYK R D Sbjct: 5039 TYKRRAAD 5046 >gi|221316622 dystonin isoform 3 [Homo sapiens] Length = 5537 Score = 2124 bits (5504), Expect = 0.0 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL Sbjct: 422 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 481 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG Sbjct: 482 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 541 Query: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS Sbjct: 542 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 601 Query: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ Sbjct: 602 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 661 Query: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE Sbjct: 662 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 721 Query: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH Sbjct: 722 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781 Query: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI Sbjct: 782 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841 Query: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK Sbjct: 842 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901 Query: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK Sbjct: 902 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 961 Query: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY Sbjct: 962 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1021 Query: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV Sbjct: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081 Query: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE Sbjct: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141 Query: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY Sbjct: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261 Query: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR Sbjct: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321 Query: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI Sbjct: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381 Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM Sbjct: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441 Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE +E EH + LQ+ + + L+ Sbjct: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501 Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179 +++ GK S+ + E+ +K ++ E L K+ + NEL KQ + + Sbjct: 1502 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1561 Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203 + D+ +++ ++Y+ +L+ I Sbjct: 1562 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1621 Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248 +++ ++ + EL++ Q + +A A+ EN L +Q ++ Sbjct: 1622 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1681 Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308 ++ E +K + L+L EQ K +L + + E E + +KQ+E+ K E Sbjct: 1682 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1736 Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359 L ++ ++ R T+ + +N Q ++ G L+ + D Q Sbjct: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1792 Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410 E L QQ ++ A + K + + + Q LEK S EEK +L K+ + Sbjct: 1793 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1851 Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463 E E E+K + ++L + + +++ QE +L+ Sbjct: 1852 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1911 Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519 K+KR + ++H KG L+ R A+ + ++ + +E+ Sbjct: 1912 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 1968 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567 QRK DH ++F + + K+ DK Q + E S Sbjct: 1969 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024 Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 +E + + L RQ ETK + +I S+ + +EK LK A+ D S Sbjct: 2025 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2073 Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687 + KT D + EDL+KS N +E Q +++ +Q+ E+ + Sbjct: 2074 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2129 Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730 + +S +E+ + EQ + +Q+ + +N ++KK ++T + Sbjct: 2130 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2184 Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790 ++ S +F +++ + ++ + K+ E K E + + + ++A Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2243 Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849 + ++ EL + +Q+ E ++ +H+E H + L + K V + Sbjct: 2244 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2303 Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907 ++ KE E + +KK C + D F++ VK + + +++ + P+ Sbjct: 2304 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2357 Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931 L + ++ + L+EKW + E Sbjct: 2358 AEDLGKSLEDTKKLQEKWSLKTPE 2381 Score = 98.6 bits (244), Expect = 7e-20 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%) Query: 287 NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344 +W+ + + +L+ E G+D + + + L+ K+ + + L+ IS ++ K Sbjct: 1891 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1950 Query: 345 ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385 T+ E +L+ S Y+K N + +D ++ + Sbjct: 1951 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2010 Query: 386 LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438 L L E E +A D N+ R+ + L ++ ++ ++ +++ AE Sbjct: 2011 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066 Query: 439 LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490 LL AR ++ + +Q I+ + + + + E T + E Sbjct: 2067 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2122 Query: 491 ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550 D++ N++ +++ + +S+ L+D++ +++ ++++ +S+I + K K ++ Sbjct: 2123 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2180 Query: 551 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608 +D +S+ K + +K E + + K ++ + Sbjct: 2181 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236 Query: 609 ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665 V P K+ +L+ +++ L H+ H+ + H L+ EI + Sbjct: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2286 Query: 666 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725 + S K ++ E LS ED +++ +E+ + + V K + +E Sbjct: 2287 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2345 Query: 726 -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766 L+ ++ +++ S+ I +V N + L N LI + T Sbjct: 2346 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2401 Query: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826 P + +S + E GT TN EEF++ +S Sbjct: 2402 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2436 Query: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886 + ++M + S Y D + L+LK+ + AE KL + + +EE+ A ++ + Sbjct: 2437 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2487 Query: 887 STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932 T +W +++V++ + L+ + K + + D++ + +E + Sbjct: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547 Query: 933 -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991 W K+ ++ +WQ ++ +R + LE +L ++ L W+ + E + Sbjct: 2548 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2605 Query: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050 + L TQ Q ++L+ E ++ + ++ + S +D L+ + + Sbjct: 2606 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665 Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105 QK ++ D I Q + T+Y +L+ ++ + K + + Sbjct: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2724 Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162 + + ET++ +Q++K + L +S L E + AEL +Q + + Sbjct: 2725 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782 Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222 V + AEN ++ Q + + +Q R+ + + K + E + ++ Sbjct: 2783 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2831 Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282 + + + ++++ + ++ +T+ + ++L L +K L +L + Sbjct: 2832 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2888 Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342 N + K +K+ E L K+ EK LK K+++E I + Q E + P Sbjct: 2889 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2944 Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389 S + LQ+E D+ E L + L T N+ Q + +T +L Sbjct: 2945 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 3004 Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437 ++ + + +K + ++ E+ L+C K +L+ D + YS + Sbjct: 3005 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3064 Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492 L+ L Q++ A++ + EASD K + L++E++ E L ++VD T+ Sbjct: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3123 Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548 + + I+ + SQ F D EL+ + R ++ L++Q E K+ + L+ + A Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3181 Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608 +N +K ++ E+++ +K+ +E L++Q N+ ++ R QA E + + TI Sbjct: 3182 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3234 Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665 +R E + F L+ EH ++ Q + E + + N+ F++ Sbjct: 3235 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3286 Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714 + QQ++ +IQ+ K + L +L+ + +KV + AQ+QE Sbjct: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3346 Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772 + QD L T + + S +FK ++ + +K +++L++ + T I Sbjct: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406 Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830 G ++ + + + + L ++ + L + + Q++ + ++ + Sbjct: 3407 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3466 Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857 L + L ++ + N + K+++QI +H+ Sbjct: 3467 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3499 Score = 82.4 bits (202), Expect = 5e-15 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%) Query: 707 DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762 D+ +++++ + +LL A+ REEQ E + S+++ + L+ E+ Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3260 Query: 763 QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820 Q +E + +++ ++F++ ++E E+E L+ + + AA S+S L Sbjct: 3261 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316 Query: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880 +L+ V + + +L+ L Q +AL L + EE V K Sbjct: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3374 Query: 881 NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939 + K ++++ E++ + L+D + I E K + D ++ Sbjct: 3375 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990 L RW+ + + + R R LEGI + + +T PL++W+ +E TQ Sbjct: 3431 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490 Query: 991 QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027 E Q K L A + Q ++S E M QSK+D E Q+ Sbjct: 3491 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550 Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071 + S ++ + E++ M + V S Q + Q S ++ Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3610 Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115 QE + LR + AL+ + + GD + +++ E IK R K+ ++ Sbjct: 3611 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3670 Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161 H + +L L + + +L E L G + S+ + ELKK+ + L Sbjct: 3671 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3730 Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221 + E + L + L+K+ AE + ++YR +TI ++ E + + R +Q Sbjct: 3731 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3788 Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271 A+A+ + + E+ L++ + E T L+ + L+ KD+ ++DL + + Sbjct: 3789 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3847 Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331 K+M +EEE + K+++K L + Q+ ++ ++LE + + + Sbjct: 3848 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3900 Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390 E P TQ+ S L+ E +Q+ EE +Q+ EL A ++ M + +L Sbjct: 3901 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3959 Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449 L + S ++ + D L + ++ + L+ + ++ ++ L + Sbjct: 3960 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4019 Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493 + + +++++KIK +N +++E L +E K + E D+ A Sbjct: 4020 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4079 Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551 AV +K + + IH+ +E+E + L + + L E+F H L+ I K+ Sbjct: 4080 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4131 Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603 D I+ L + +++ E AE ++++++ L + + L + I A E + + Sbjct: 4132 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4191 Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650 K++I + A +KD++ E + + + Q + + Sbjct: 4192 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4251 Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703 DL + + E KQ + Q + E N AEL K + + VQ Sbjct: 4252 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309 Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754 + + + + NR K++ L L + +TH + +L +++ A E Sbjct: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369 Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808 ++++ V+ +G L S +E S Q ++ + + + + Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429 Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868 Q ++Q+ + + + L+ L +R + L K + E + + + E+ Sbjct: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4487 Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928 AK+ T+K L + L P+S Q+ L+EKW+ Sbjct: 4488 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4533 Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968 + ++ + + +E S Q + + +Q L + Sbjct: 4534 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4574 Score = 77.8 bits (190), Expect = 1e-13 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%) Query: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801 Y S +R++ +L + +++L + D +++ ++ +K+K+E+++ K + Sbjct: 2695 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2751 Query: 802 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857 CE+ + L +L +L++ V + ++ L++ + + ++ Sbjct: 2752 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2811 Query: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917 +A + + + + + A + +E+LI K + + + ++ K I+ Sbjct: 2812 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2862 Query: 918 DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976 + K + + + + + + W + Q+ R L E + K+LK Y++ L Sbjct: 2863 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2921 Query: 977 DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017 WI + + +I+ EN K+L +++Q L+S E+ Sbjct: 2922 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2981 Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070 K+ DE + ++ K + L+ MT + + Q+ S +R++Q + + L Sbjct: 2982 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3040 Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124 I + + + +T++ Q +K D KRL ++ + E S+ SD+L Sbjct: 3041 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3097 Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170 + + E+S L+ ++ E + + E+ Q + ++EL + + Sbjct: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157 Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229 E ++Q+ L+K+ A + + ++ E +L +++ +EA +K+ Sbjct: 3158 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3216 Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289 + R + E T +R E + K K+ S + QK + EE + E E + Sbjct: 3217 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3272 Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349 +Q+ FQK+ E ++Q + N L I A + Sbjct: 3273 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3313 Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396 GL+ + D K+ A+ Q + L R + L++ ++ +L +K Sbjct: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373 Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442 S E + +LL+ LD+ +T+ +K E E+ + A+K +QL L Sbjct: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3433 Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489 + KAE ++ + + + + LE LN EK G +++ Sbjct: 3434 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3493 Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537 H E +I + N +H S R++K++ + ++ + +++ Q EKS Sbjct: 3494 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3552 Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591 H +LLQ A+ D+++ +N E ++ +++ Q E L +Q +E +++ + Sbjct: 3553 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3612 Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646 I +N+ Q + E LK Q G +D+L + TK D Sbjct: 3613 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3665 Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705 K LE+ L ++ L S ++ C + ++ E + L E AS+ + R E K + + Sbjct: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3724 Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761 + L + L +V L L+ + + + E++ +++ ++ +K+E++ Sbjct: 3725 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781 Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810 E ITE + + L + L+Q+ + AQ ++ +T E+ R Sbjct: 3782 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3839 Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 + ++ G + + E +++K+K+D+ +K ++ Sbjct: 3840 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3873 Score = 72.8 bits (177), Expect = 4e-12 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311 +S LL Q L +I + +L+NW++E+ +L + W S+L + E Sbjct: 3555 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614 Query: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371 L +NV +A+ LK+ E+ L +KL ++++Y + S + + Sbjct: 3615 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3667 Query: 372 LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425 L+ R +T+E + WL++ E E ++Y+ T + + ++ MR EL ++ Sbjct: 3668 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3722 Query: 426 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485 +N K++ + L E A L + +RA + +E+ + E+ + Sbjct: 3723 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3766 Query: 486 NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542 +D T + + AI R D++ + + + + ++ M + L+ T A L + Sbjct: 3767 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3824 Query: 543 GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601 K T+ L+ ++ D +K+ I C + + K D+ VL N + I Sbjct: 3825 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3877 Query: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661 +E + + A L N+ + Y+ L W ++ S + L E Sbjct: 3878 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3927 Query: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718 R + ++ ++ EH+ + + LE S G + EK V + Sbjct: 3928 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3980 Query: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778 Q +++ K A ++ S + ++ I LE +RL + E + + E Sbjct: 3981 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4037 Query: 779 RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835 +I+E + + ++E+L+ T+ + EE +++ + S ++ +L+ ++ ++ Sbjct: 4038 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4097 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886 ++ KL V ++L E C+ ++I + ++ I Sbjct: 4098 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144 Query: 887 -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945 S +KQ + + R+ L++EL + E+ E D K+ D+L W Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4202 Query: 946 QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003 +++ +R+ LE ++ Y+D + DW V+ K+ P + +T+ Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4259 Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057 Q+ + K SE +Q +M+ AE V + + M + + DS ++ Sbjct: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4319 Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113 + R+ A L + +F A +T L+++ GD K +E E K Sbjct: 4320 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4373 Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173 H +D+L Q +TV +K + E + ++ S ++ +L + + +N L Sbjct: 4374 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4426 Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222 K ++ + + A +AK + E+E + + ER L QL + Sbjct: 4427 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4482 Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281 E AA E +++ +++ R + D +N+L+++ + +L ++ Sbjct: 4483 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4541 Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337 EE L L + +D AE+ L + L + +I ++ N + Sbjct: 4542 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4601 Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397 + T L+ KQ +K + + + K Q + E L+ + Sbjct: 4602 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4661 Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451 E L + L+E+ +L +LE+ K Q +E + L TT + Sbjct: 4662 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4720 Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511 +++E + L + L+L+ + E L+ + D I + ++ F Sbjct: 4721 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4773 Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571 D + + + + ++Q L+ N+ D + +EL K + Sbjct: 4774 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4827 Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 LK+ EL + + K+ MQ + E + + Q R EA QA+ F + + Sbjct: 4828 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4887 Query: 1628 TNEHLHKQTKT 1638 E L + +T Sbjct: 4888 LLEWLAEAEQT 4898 Score = 53.9 bits (128), Expect = 2e-06 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%) Query: 260 KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308 KP++K S+ + N + +N + +Q + + D +Q D + G L S+ Sbjct: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247 Query: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368 + + V + IEE + EA +I+M RL Q A+LL + Sbjct: 4248 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4294 Query: 369 ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426 E T+ + + +LIW + EE + +A + HA EL+ L E Sbjct: 4295 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4351 Query: 427 ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486 + +EQ + P + IE + H+ +N Sbjct: 4352 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4385 Query: 487 DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546 EA + N D I+ + S+ +KLE L Q E+ Q K + + +AK Sbjct: 4386 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443 Query: 547 TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 +Q +++ L S P+ + + + ++ ++ E A + +K + Sbjct: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4501 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651 G + + P + +D N +++++++V T +E ++ + Sbjct: 4502 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4556 Query: 652 SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710 S IN + + + NVAS +++ + L E +VF+ + Sbjct: 4557 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4602 Query: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766 E+ + + K LK +++ + NL IS ++ R E RL+ + R+ Sbjct: 4603 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4656 Query: 767 PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817 HE+ ++ E ++ L ELE D + T + +EF A SV Sbjct: 4657 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4716 Query: 818 ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856 +L+ + ++ N+ ++ M S DK T+ ++ +N T Sbjct: 4717 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4775 Query: 857 AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913 A +AL+ LY E +L E++ V D + + NLI K ++ E+ ++ AL Sbjct: 4776 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4828 Query: 914 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973 K + E+ + ++ D W K + +L RW+ V ++ LE + + + Sbjct: 4829 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4885 Query: 974 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024 H L +W+ + E T R P++ L T ++Q K + ++E K++++++ Sbjct: 4886 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4935 Score = 40.8 bits (94), Expect = 0.018 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%) Query: 282 VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339 +Q L++W+ ++ QL D+ G D+ V + ++NHK + + + SS++ K S ++ Sbjct: 4777 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4835 Query: 340 -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392 ++ +K+ E R E+ A ++ E L F S L WL E Sbjct: 4836 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4895 Query: 393 EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449 E+ + + + R D H E M++L++K + + + +L HP +T Sbjct: 4896 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955 Query: 450 ---IEAYRAAMQTQWSWILQ 466 I RA + +W Q Sbjct: 4956 KHWITIIRARFEEVLAWAKQ 4975 Score = 40.0 bits (92), Expect = 0.031 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%) Query: 242 SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294 S+G E ++LQ L+++ R K + LD L + + ++DL W+ + + Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461 Query: 295 QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351 L ++ LP + + L H V A E E + K QM A + + Sbjct: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521 Query: 352 ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394 + ES KL E L+ F + + + WL + E+ Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581 Query: 395 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453 + V + E A + + H E + ELD+ ++K + + +L++N Sbjct: 4582 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4631 Query: 454 RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513 ++Q++W ++Q + VE+ R+L DA RK R+ Sbjct: 4632 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4662 Query: 514 IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572 H+ + E +EE E+ L + IAN K KT + Q K K S+ Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722 Query: 573 RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622 R + E T DD L + + R KW I EA++ S FT + Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4780 Query: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682 +D R+E Q + + + M + + E+ + R S+V ++K Sbjct: 4781 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4829 Query: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742 + + E +DS +V +++ + V Q L++A R+ +E + Sbjct: 4830 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4881 Query: 743 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802 S V + L E L P + D L I + ++ K+LE + +L T Sbjct: 4882 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4938 Query: 803 KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862 + + S+ T++ + ++ +V + + + +L + L A + L+ Sbjct: 4939 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4994 Query: 863 KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922 + L E + DK+ + Q EV +E+ + + D++ K Sbjct: 4995 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5049 Query: 923 TYKERDLD 930 TYK R D Sbjct: 5050 TYKRRAAD 5057 >gi|221316618 dystonin isoform 2 [Homo sapiens] Length = 5675 Score = 2124 bits (5504), Expect = 0.0 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL Sbjct: 560 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 619 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG Sbjct: 620 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 679 Query: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS Sbjct: 680 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 739 Query: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ Sbjct: 740 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 799 Query: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE Sbjct: 800 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 859 Query: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH Sbjct: 860 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 919 Query: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI Sbjct: 920 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 979 Query: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK Sbjct: 980 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 1039 Query: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK Sbjct: 1040 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 1099 Query: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY Sbjct: 1100 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1159 Query: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV Sbjct: 1160 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1219 Query: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1279 Query: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1399 Query: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR Sbjct: 1400 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1459 Query: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI Sbjct: 1460 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1519 Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1579 Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE +E EH + LQ+ + + L+ Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1639 Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179 +++ GK S+ + E+ +K ++ E L K+ + NEL KQ + + Sbjct: 1640 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1699 Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203 + D+ +++ ++Y+ +L+ I Sbjct: 1700 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1759 Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248 +++ ++ + EL++ Q + +A A+ EN L +Q ++ Sbjct: 1760 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1819 Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308 ++ E +K + L+L EQ K +L + + E E + +KQ+E+ K E Sbjct: 1820 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1874 Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359 L ++ ++ R T+ + +N Q ++ G L+ + D Q Sbjct: 1875 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1930 Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410 E L QQ ++ A + K + + + Q LEK S EEK +L K+ + Sbjct: 1931 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1989 Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463 E E E+K + ++L + + +++ QE +L+ Sbjct: 1990 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 2049 Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519 K+KR + ++H KG L+ R A+ + ++ + +E+ Sbjct: 2050 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 2106 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567 QRK DH ++F + + K+ DK Q + E S Sbjct: 2107 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2162 Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 +E + + L RQ ETK + +I S+ + +EK LK A+ D S Sbjct: 2163 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2211 Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687 + KT D + EDL+KS N +E Q +++ +Q+ E+ + Sbjct: 2212 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2267 Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730 + +S +E+ + EQ + +Q+ + +N ++KK ++T + Sbjct: 2268 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2322 Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790 ++ S +F +++ + ++ + K+ E K E + + + ++A Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2381 Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849 + ++ EL + +Q+ E ++ +H+E H + L + K V + Sbjct: 2382 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2441 Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907 ++ KE E + +KK C + D F++ VK + + +++ + P+ Sbjct: 2442 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2495 Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931 L + ++ + L+EKW + E Sbjct: 2496 AEDLGKSLEDTKKLQEKWSLKTPE 2519 Score = 98.6 bits (244), Expect = 7e-20 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%) Query: 287 NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344 +W+ + + +L+ E G+D + + + L+ K+ + + L+ IS ++ K Sbjct: 2029 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 2088 Query: 345 ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385 T+ E +L+ S Y+K N + +D ++ + Sbjct: 2089 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2148 Query: 386 LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438 L L E E +A D N+ R+ + L ++ ++ ++ +++ AE Sbjct: 2149 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2204 Query: 439 LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490 LL AR ++ + +Q I+ + + + + E T + E Sbjct: 2205 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2260 Query: 491 ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550 D++ N++ +++ + +S+ L+D++ +++ ++++ +S+I + K K ++ Sbjct: 2261 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2318 Query: 551 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608 +D +S+ K + +K E + + K ++ + Sbjct: 2319 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2374 Query: 609 ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665 V P K+ +L+ +++ L H+ H+ + H L+ EI + Sbjct: 2375 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2424 Query: 666 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725 + S K ++ E LS ED +++ +E+ + + V K + +E Sbjct: 2425 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2483 Query: 726 -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766 L+ ++ +++ S+ I +V N + L N LI + T Sbjct: 2484 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2539 Query: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826 P + +S + E GT TN EEF++ +S Sbjct: 2540 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2574 Query: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886 + ++M + S Y D + L+LK+ + AE KL + + +EE+ A ++ + Sbjct: 2575 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2625 Query: 887 STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932 T +W +++V++ + L+ + K + + D++ + +E + Sbjct: 2626 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2685 Query: 933 -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991 W K+ ++ +WQ ++ +R + LE +L ++ L W+ + E + Sbjct: 2686 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2743 Query: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050 + L TQ Q ++L+ E ++ + ++ + S +D L+ + + Sbjct: 2744 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2803 Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105 QK ++ D I Q + T+Y +L+ ++ + K + + Sbjct: 2804 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2862 Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162 + + ET++ +Q++K + L +S L E + AEL +Q + + Sbjct: 2863 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2920 Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222 V + AEN ++ Q + + +Q R+ + + K + E + ++ Sbjct: 2921 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2969 Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282 + + + ++++ + ++ +T+ + ++L L +K L +L + Sbjct: 2970 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 3026 Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342 N + K +K+ E L K+ EK LK K+++E I + Q E + P Sbjct: 3027 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 3082 Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389 S + LQ+E D+ E L + L T N+ Q + +T +L Sbjct: 3083 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 3142 Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437 ++ + + +K + ++ E+ L+C K +L+ D + YS + Sbjct: 3143 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3202 Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492 L+ L Q++ A++ + EASD K + L++E++ E L ++VD T+ Sbjct: 3203 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3261 Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548 + + I+ + SQ F D EL+ + R ++ L++Q E K+ + L+ + A Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3319 Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608 +N +K ++ E+++ +K+ +E L++Q N+ ++ R QA E + + TI Sbjct: 3320 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3372 Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665 +R E + F L+ EH ++ Q + E + + N+ F++ Sbjct: 3373 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3424 Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714 + QQ++ +IQ+ K + L +L+ + +KV + AQ+QE Sbjct: 3425 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3484 Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772 + QD L T + + S +FK ++ + +K +++L++ + T I Sbjct: 3485 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3544 Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830 G ++ + + + + L ++ + L + + Q++ + ++ + Sbjct: 3545 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3604 Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857 L + L ++ + N + K+++QI +H+ Sbjct: 3605 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3637 Score = 82.4 bits (202), Expect = 5e-15 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%) Query: 707 DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762 D+ +++++ + +LL A+ REEQ E + S+++ + L+ E+ Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3398 Query: 763 QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820 Q +E + +++ ++F++ ++E E+E L+ + + AA S+S L Sbjct: 3399 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454 Query: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880 +L+ V + + +L+ L Q +AL L + EE V K Sbjct: 3455 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3512 Query: 881 NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939 + K ++++ E++ + L+D + I E K + D ++ Sbjct: 3513 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3568 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990 L RW+ + + + R R LEGI + + +T PL++W+ +E TQ Sbjct: 3569 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3628 Query: 991 QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027 E Q K L A + Q ++S E M QSK+D E Q+ Sbjct: 3629 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688 Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071 + S ++ + E++ M + V S Q + Q S ++ Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3748 Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115 QE + LR + AL+ + + GD + +++ E IK R K+ ++ Sbjct: 3749 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3808 Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161 H + +L L + + +L E L G + S+ + ELKK+ + L Sbjct: 3809 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3868 Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221 + E + L + L+K+ AE + ++YR +TI ++ E + + R +Q Sbjct: 3869 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3926 Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271 A+A+ + + E+ L++ + E T L+ + L+ KD+ ++DL + + Sbjct: 3927 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3985 Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331 K+M +EEE + K+++K L + Q+ ++ ++LE + + + Sbjct: 3986 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 4038 Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390 E P TQ+ S L+ E +Q+ EE +Q+ EL A ++ M + +L Sbjct: 4039 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 4097 Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449 L + S ++ + D L + ++ + L+ + ++ ++ L + Sbjct: 4098 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4157 Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493 + + +++++KIK +N +++E L +E K + E D+ A Sbjct: 4158 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4217 Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551 AV +K + + IH+ +E+E + L + + L E+F H L+ I K+ Sbjct: 4218 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4269 Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603 D I+ L + +++ E AE ++++++ L + + L + I A E + + Sbjct: 4270 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4329 Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650 K++I + A +KD++ E + + + Q + + Sbjct: 4330 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4389 Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703 DL + + E KQ + Q + E N AEL K + + VQ Sbjct: 4390 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4447 Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754 + + + + NR K++ L L + +TH + +L +++ A E Sbjct: 4448 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4507 Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808 ++++ V+ +G L S +E S Q ++ + + + + Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567 Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868 Q ++Q+ + + + L+ L +R + L K + E + + + E+ Sbjct: 4568 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4625 Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928 AK+ T+K L + L P+S Q+ L+EKW+ Sbjct: 4626 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4671 Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968 + ++ + + +E S Q + + +Q L + Sbjct: 4672 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4712 Score = 77.8 bits (190), Expect = 1e-13 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%) Query: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801 Y S +R++ +L + +++L + D +++ ++ +K+K+E+++ K + Sbjct: 2833 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2889 Query: 802 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857 CE+ + L +L +L++ V + ++ L++ + + ++ Sbjct: 2890 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2949 Query: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917 +A + + + + + A + +E+LI K + + + ++ K I+ Sbjct: 2950 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 3000 Query: 918 DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976 + K + + + + + + W + Q+ R L E + K+LK Y++ L Sbjct: 3001 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 3059 Query: 977 DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017 WI + + +I+ EN K+L +++Q L+S E+ Sbjct: 3060 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 3119 Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070 K+ DE + ++ K + L+ MT + + Q+ S +R++Q + + L Sbjct: 3120 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3178 Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124 I + + + +T++ Q +K D KRL ++ + E S+ SD+L Sbjct: 3179 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3235 Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170 + + E+S L+ ++ E + + E+ Q + ++EL + + Sbjct: 3236 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3295 Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229 E ++Q+ L+K+ A + + ++ E +L +++ +EA +K+ Sbjct: 3296 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3354 Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289 + R + E T +R E + K K+ S + QK + EE + E E + Sbjct: 3355 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3410 Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349 +Q+ FQK+ E ++Q + N L I A + Sbjct: 3411 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3451 Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396 GL+ + D K+ A+ Q + L R + L++ ++ +L +K Sbjct: 3452 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3511 Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442 S E + +LL+ LD+ +T+ +K E E+ + A+K +QL L Sbjct: 3512 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3571 Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489 + KAE ++ + + + + LE LN EK G +++ Sbjct: 3572 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3631 Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537 H E +I + N +H S R++K++ + ++ + +++ Q EKS Sbjct: 3632 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3690 Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591 H +LLQ A+ D+++ +N E ++ +++ Q E L +Q +E +++ + Sbjct: 3691 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3750 Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646 I +N+ Q + E LK Q G +D+L + TK D Sbjct: 3751 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3803 Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705 K LE+ L ++ L S ++ C + ++ E + L E AS+ + R E K + + Sbjct: 3804 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3862 Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761 + L + L +V L L+ + + + E++ +++ ++ +K+E++ Sbjct: 3863 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3919 Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810 E ITE + + L + L+Q+ + AQ ++ +T E+ R Sbjct: 3920 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3977 Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 + ++ G + + E +++K+K+D+ +K ++ Sbjct: 3978 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 4011 Score = 72.8 bits (177), Expect = 4e-12 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311 +S LL Q L +I + +L+NW++E+ +L + W S+L + E Sbjct: 3693 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3752 Query: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371 L +NV +A+ LK+ E+ L +KL ++++Y + S + + Sbjct: 3753 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3805 Query: 372 LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425 L+ R +T+E + WL++ E E ++Y+ T + + ++ MR EL ++ Sbjct: 3806 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3860 Query: 426 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485 +N K++ + L E A L + +RA + +E+ + E+ + Sbjct: 3861 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3904 Query: 486 NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542 +D T + + AI R D++ + + + + ++ M + L+ T A L + Sbjct: 3905 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3962 Query: 543 GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601 K T+ L+ ++ D +K+ I C + + K D+ VL N + I Sbjct: 3963 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 4015 Query: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661 +E + + A L N+ + Y+ L W ++ S + L E Sbjct: 4016 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 4065 Query: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718 R + ++ ++ EH+ + + LE S G + EK V + Sbjct: 4066 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 4118 Query: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778 Q +++ K A ++ S + ++ I LE +RL + E + + E Sbjct: 4119 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4175 Query: 779 RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835 +I+E + + ++E+L+ T+ + EE +++ + S ++ +L+ ++ ++ Sbjct: 4176 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4235 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886 ++ KL V ++L E C+ ++I + ++ I Sbjct: 4236 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4282 Query: 887 -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945 S +KQ + + R+ L++EL + E+ E D K+ D+L W Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4340 Query: 946 QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003 +++ +R+ LE ++ Y+D + DW V+ K+ P + +T+ Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4397 Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057 Q+ + K SE +Q +M+ AE V + + M + + DS ++ Sbjct: 4398 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4457 Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113 + R+ A L + +F A +T L+++ GD K +E E K Sbjct: 4458 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4511 Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173 H +D+L Q +TV +K + E + ++ S ++ +L + + +N L Sbjct: 4512 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4564 Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222 K ++ + + A +AK + E+E + + ER L QL + Sbjct: 4565 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4620 Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281 E AA E +++ +++ R + D +N+L+++ + +L ++ Sbjct: 4621 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4679 Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337 EE L L + +D AE+ L + L + +I ++ N + Sbjct: 4680 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4739 Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397 + T L+ KQ +K + + + K Q + E L+ + Sbjct: 4740 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4799 Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451 E L + L+E+ +L +LE+ K Q +E + L TT + Sbjct: 4800 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4858 Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511 +++E + L + L+L+ + E L+ + D I + ++ F Sbjct: 4859 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4911 Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571 D + + + + ++Q L+ N+ D + +EL K + Sbjct: 4912 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4965 Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 LK+ EL + + K+ MQ + E + + Q R EA QA+ F + + Sbjct: 4966 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 5025 Query: 1628 TNEHLHKQTKT 1638 E L + +T Sbjct: 5026 LLEWLAEAEQT 5036 Score = 53.9 bits (128), Expect = 2e-06 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%) Query: 260 KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308 KP++K S+ + N + +N + +Q + + D +Q D + G L S+ Sbjct: 4326 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4385 Query: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368 + + V + IEE + EA +I+M RL Q A+LL + Sbjct: 4386 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4432 Query: 369 ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426 E T+ + + +LIW + EE + +A + HA EL+ L E Sbjct: 4433 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4489 Query: 427 ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486 + +EQ + P + IE + H+ +N Sbjct: 4490 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4523 Query: 487 DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546 EA + N D I+ + S+ +KLE L Q E+ Q K + + +AK Sbjct: 4524 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4581 Query: 547 TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 +Q +++ L S P+ + + + ++ ++ E A + +K + Sbjct: 4582 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4639 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651 G + + P + +D N +++++++V T +E ++ + Sbjct: 4640 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4694 Query: 652 SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710 S IN + + + NVAS +++ + L E +VF+ + Sbjct: 4695 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4740 Query: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766 E+ + + K LK +++ + NL IS ++ R E RL+ + R+ Sbjct: 4741 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4794 Query: 767 PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817 HE+ ++ E ++ L ELE D + T + +EF A SV Sbjct: 4795 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4854 Query: 818 ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856 +L+ + ++ N+ ++ M S DK T+ ++ +N T Sbjct: 4855 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4913 Query: 857 AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913 A +AL+ LY E +L E++ V D + + NLI K ++ E+ ++ AL Sbjct: 4914 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4966 Query: 914 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973 K + E+ + ++ D W K + +L RW+ V ++ LE + + + Sbjct: 4967 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 5023 Query: 974 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024 H L +W+ + E T R P++ L T ++Q K + ++E K++++++ Sbjct: 5024 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 5073 Score = 40.8 bits (94), Expect = 0.018 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%) Query: 282 VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339 +Q L++W+ ++ QL D+ G D+ V + ++NHK + + + SS++ K S ++ Sbjct: 4915 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4973 Query: 340 -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392 ++ +K+ E R E+ A ++ E L F S L WL E Sbjct: 4974 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 5033 Query: 393 EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449 E+ + + + R D H E M++L++K + + + +L HP +T Sbjct: 5034 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093 Query: 450 ---IEAYRAAMQTQWSWILQ 466 I RA + +W Q Sbjct: 5094 KHWITIIRARFEEVLAWAKQ 5113 Score = 40.0 bits (92), Expect = 0.031 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%) Query: 242 SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294 S+G E ++LQ L+++ R K + LD L + + ++DL W+ + + Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599 Query: 295 QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351 L ++ LP + + L H V A E E + K QM A + + Sbjct: 4600 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4659 Query: 352 ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394 + ES KL E L+ F + + + WL + E+ Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719 Query: 395 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453 + V + E A + + H E + ELD+ ++K + + +L++N Sbjct: 4720 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4769 Query: 454 RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513 ++Q++W ++Q + VE+ R+L DA RK R+ Sbjct: 4770 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4800 Query: 514 IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572 H+ + E +EE E+ L + IAN K KT + Q K K S+ Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860 Query: 573 RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622 R + E T DD L + + R KW I EA++ S FT + Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4918 Query: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682 +D R+E Q + + + M + + E+ + R S+V ++K Sbjct: 4919 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4967 Query: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742 + + E +DS +V +++ + V Q L++A R+ +E + Sbjct: 4968 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 5019 Query: 743 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802 S V + L E L P + D L I + ++ K+LE + +L T Sbjct: 5020 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 5076 Query: 803 KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862 + + S+ T++ + ++ +V + + + +L + L A + L+ Sbjct: 5077 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 5132 Query: 863 KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922 + L E + DK+ + Q EV +E+ + + D++ K Sbjct: 5133 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5187 Query: 923 TYKERDLD 930 TYK R D Sbjct: 5188 TYKRRAAD 5195 >gi|34577047 dystonin isoform 1 [Homo sapiens] Length = 5497 Score = 2124 bits (5504), Expect = 0.0 Identities = 1225/2004 (61%), Positives = 1413/2004 (70%), Gaps = 172/2004 (8%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL Sbjct: 382 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 441 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG Sbjct: 442 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 501 Query: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS Sbjct: 502 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 561 Query: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ Sbjct: 562 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 621 Query: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE Sbjct: 622 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 681 Query: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH Sbjct: 682 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 741 Query: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI Sbjct: 742 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 801 Query: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK Sbjct: 802 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 861 Query: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK Sbjct: 862 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 921 Query: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY Sbjct: 922 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 981 Query: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV Sbjct: 982 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1041 Query: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE Sbjct: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101 Query: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY Sbjct: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1221 Query: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR Sbjct: 1222 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1281 Query: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI Sbjct: 1282 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1341 Query: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM Sbjct: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401 Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE +E EH + LQ+ + + L+ Sbjct: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461 Query: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179 +++ GK S+ + E+ +K ++ E L K+ + NEL KQ + + Sbjct: 1462 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1521 Query: 1180 E---------------------DISLQKIRAESEAKQYRRELETI--------------- 1203 + D+ +++ ++Y+ +L+ I Sbjct: 1522 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1581 Query: 1204 -----------VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR----NQLEENTFT 1248 +++ ++ + EL++ Q + +A A+ EN L +Q ++ Sbjct: 1582 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1641 Query: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308 ++ E +K + L+L EQ K +L + + E E + +KQ+E+ K E Sbjct: 1642 QKLNEAKIKCEQLNLK-AEQSKKELDKVVTTAIKEETEKVAAVKQLEE----SKTKIENL 1696 Query: 1309 LKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG---------LQQEHDKQ 1359 L ++ ++ R T+ + +N Q ++ G L+ + D Q Sbjct: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHF----QEGDGKSAIGEEDEVNGNLLETDVDGQ 1752 Query: 1360 ---KAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEK----TSSEEKARLLKDKL 1410 E L QQ ++ A + K + + + Q LEK S EEK +L K+ + Sbjct: 1753 VGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-M 1811 Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK------- 1463 E E E+K + ++L + + +++ QE +L+ Sbjct: 1812 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1871 Query: 1464 ----KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELER 1519 K+KR + ++H KG L+ R A+ + ++ + +E+ Sbjct: 1872 GLMTKLKRQKSFSEDVISH-KGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-- 1928 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE------------ELEKSNE 1567 QRK DH ++F + + K+ DK Q + E S Sbjct: 1929 ----QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984 Query: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 +E + + L RQ ETK + +I S+ + +EK LK A+ D S Sbjct: 1985 LSEPIAVDPKNLQRQLEETKALQGQI--SSQQVAVEK---------LKKTAEVLLDARGS 2033 Query: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687 + KT D + EDL+KS N +E Q +++ +Q+ E+ + Sbjct: 2034 LLPAKNDIQKTLDDIVGRY----EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2089 Query: 1688 LNASKEEKRRG-----------------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEE 1730 + +S +E+ + EQ + +Q+ + +N ++KK ++T + Sbjct: 2090 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDP 2144 Query: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ 1790 ++ S +F +++ + ++ + K+ E K E + + + ++A Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQAL 2203 Query: 1791 ENAKLCETNIKELERQLQQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849 + ++ EL + +Q+ E ++ +H+E H + L + K V + Sbjct: 2204 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL 2263 Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-P 1907 ++ KE E + +KK C + D F++ VK + + +++ + P+ Sbjct: 2264 SKKFKEMEDTIK------EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2317 Query: 1908 RSPLLRWTQEPQPLEEKWQHRVVE 1931 L + ++ + L+EKW + E Sbjct: 2318 AEDLGKSLEDTKKLQEKWSLKTPE 2341 Score = 98.6 bits (244), Expect = 7e-20 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%) Query: 287 NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344 +W+ + + +L+ E G+D + + + L+ K+ + + L+ IS ++ K Sbjct: 1851 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1910 Query: 345 ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385 T+ E +L+ S Y+K N + +D ++ + Sbjct: 1911 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1970 Query: 386 LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438 L L E E +A D N+ R+ + L ++ ++ ++ +++ AE Sbjct: 1971 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026 Query: 439 LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490 LL AR ++ + +Q I+ + + + + E T + E Sbjct: 2027 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2082 Query: 491 ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550 D++ N++ +++ + +S+ L+D++ +++ ++++ +S+I + K K ++ Sbjct: 2083 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2140 Query: 551 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608 +D +S+ K + +K E + + K ++ + Sbjct: 2141 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196 Query: 609 ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665 V P K+ +L+ +++ L H+ H+ + H L+ EI + Sbjct: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2246 Query: 666 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725 + S K ++ E LS ED +++ +E+ + + V K + +E Sbjct: 2247 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2305 Query: 726 -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766 L+ ++ +++ S+ I +V N + L N LI + T Sbjct: 2306 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2361 Query: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826 P + +S + E GT TN EEF++ +S Sbjct: 2362 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2396 Query: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886 + ++M + S Y D + L+LK+ + AE KL + + +EE+ A ++ + Sbjct: 2397 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2447 Query: 887 STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932 T +W +++V++ + L+ + K + + D++ + +E + Sbjct: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507 Query: 933 -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991 W K+ ++ +WQ ++ +R + LE +L ++ L W+ + E + Sbjct: 2508 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2565 Query: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050 + L TQ Q ++L+ E ++ + ++ + S +D L+ + + Sbjct: 2566 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2625 Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105 QK ++ D I Q + T+Y +L+ ++ + K + + Sbjct: 2626 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2684 Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162 + + ET++ +Q++K + L +S L E + AEL +Q + + Sbjct: 2685 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2742 Query: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222 V + AEN ++ Q + + +Q R+ + + K + E + ++ Sbjct: 2743 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2791 Query: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282 + + + ++++ + ++ +T+ + ++L L +K L +L + Sbjct: 2792 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2848 Query: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342 N + K +K+ E L K+ EK LK K+++E I + Q E + P Sbjct: 2849 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2904 Query: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389 S + LQ+E D+ E L + L T N+ Q + +T +L Sbjct: 2905 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2964 Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437 ++ + + +K + ++ E+ L+C K +L+ D + YS + Sbjct: 2965 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3024 Query: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492 L+ L Q++ A++ + EASD K + L++E++ E L ++VD T+ Sbjct: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3083 Query: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548 + + I+ + SQ F D EL+ + R ++ L++Q E K+ + L+ + A Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3141 Query: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608 +N +K ++ E+++ +K+ +E L++Q N+ ++ R QA E + + TI Sbjct: 3142 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3194 Query: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665 +R E + F L+ EH ++ Q + E + + N+ F++ Sbjct: 3195 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3246 Query: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714 + QQ++ +IQ+ K + L +L+ + +KV + AQ+QE Sbjct: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3306 Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772 + QD L T + + S +FK ++ + +K +++L++ + T I Sbjct: 3307 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3366 Query: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830 G ++ + + + + L ++ + L + + Q++ + ++ + Sbjct: 3367 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3426 Query: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857 L + L ++ + N + K+++QI +H+ Sbjct: 3427 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3459 Score = 82.4 bits (202), Expect = 5e-15 Identities = 269/1421 (18%), Positives = 556/1421 (39%), Gaps = 206/1421 (14%) Query: 707 DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762 D+ +++++ + +LL A+ REEQ E + S+++ + L+ E+ Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3220 Query: 763 QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820 Q +E + +++ ++F++ ++E E+E L+ + + AA S+S L Sbjct: 3221 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276 Query: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880 +L+ V + + +L+ L Q +AL L + EE V K Sbjct: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3334 Query: 881 NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939 + K ++++ E++ + L+D + I E K + D ++ Sbjct: 3335 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET---------TQRKI 990 L RW+ + + + R R LEGI + + +T PL++W+ +E TQ Sbjct: 3391 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450 Query: 991 QENQPENSKTL-------------ATQLNQQKMLVSEIE---MKQSKMD-------ECQK 1027 E Q K L A + Q ++S E M QSK+D E Q+ Sbjct: 3451 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3510 Query: 1028 YAEQYSATVK----------DYELQTMTYRAMVD------SQQKSPVKRRRMQSSADLII 1071 + S ++ + E++ M + V S Q + Q S ++ Sbjct: 3511 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3570 Query: 1072 QEFMDLRTRYT--ALVTLMTQYIKFAGDSLKRLEE--EEIK-RCKETSE----------- 1115 QE + LR + AL+ + + GD + +++ E IK R K+ ++ Sbjct: 3571 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3630 Query: 1116 --------HGAYSDL---LQRQKATVL--ENSKLTG-KISELERMVAELKKQKSRVEEEL 1161 H + +L L + + +L E L G + S+ + ELKK+ + L Sbjct: 3631 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3690 Query: 1162 PKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221 + E + L + L+K+ AE + ++YR +TI ++ E + + R +Q Sbjct: 3691 DSLNEVSSALLELVPWRARE-GLEKMVAE-DNERYRLVSDTITQKVEEIDAAILRSQQFD 3748 Query: 1222 IEAEAKRAAV---EENLLNFRNQLEENTFTRRTLE-------DHLKRKDLSLNDLEQQKN 1271 A+A+ + + E+ L++ + E T L+ + L+ KD+ ++DL + + Sbjct: 3749 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI-IDDLVKSGH 3807 Query: 1272 KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR 1331 K+M +EEE + K+++K L + Q+ ++ ++LE + + + Sbjct: 3808 KIMTAC-----SEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETY 3860 Query: 1332 ENALPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390 E P TQ+ S L+ E +Q+ EE +Q+ EL A ++ M + +L Sbjct: 3861 EELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLL 3919 Query: 1391 ALQLEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449 L + S ++ + D L + ++ + L+ + ++ ++ L + Sbjct: 3920 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3979 Query: 1450 GKAEEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRA 1493 + + +++++KIK +N +++E L +E K + E D+ A Sbjct: 3980 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4039 Query: 1494 HAVAEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN 1551 AV +K + + IH+ +E+E + L + + L E+F H L+ I K+ Sbjct: 4040 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDT 4091 Query: 1552 NDKIQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLE 1603 D I+ L + +++ E AE ++++++ L + + L + I A E + + Sbjct: 4092 QDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4151 Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLE 1650 K++I + A +KD++ E + + + Q + + Sbjct: 4152 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4211 Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ------- 1703 DL + + E KQ + Q + E N AEL K + + VQ Sbjct: 4212 TDLETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269 Query: 1704 -LQQAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754 + + + + NR K++ L L + +TH + +L +++ A E Sbjct: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4329 Query: 1755 RKKMEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808 ++++ V+ +G L S +E S Q ++ + + + + Sbjct: 4330 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389 Query: 1809 QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQ 1868 Q ++Q+ + + + L+ L +R + L K + E + + + E+ Sbjct: 4390 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVC 4447 Query: 1869 KKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHR 1928 AK+ T+K L + L P+S Q+ L+EKW+ Sbjct: 4448 AAFEAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV 4493 Query: 1929 VVEQIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968 + ++ + + +E S Q + + +Q L + Sbjct: 4494 ETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4534 Score = 77.8 bits (190), Expect = 1e-13 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%) Query: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801 Y S +R++ +L + +++L + D +++ ++ +K+K+E+++ K + Sbjct: 2655 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2711 Query: 802 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857 CE+ + L +L +L++ V + ++ L++ + + ++ Sbjct: 2712 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2771 Query: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917 +A + + + + + A + +E+LI K + + + ++ K I+ Sbjct: 2772 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2822 Query: 918 DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976 + K + + + + + + W + Q+ R L E + K+LK Y++ L Sbjct: 2823 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2881 Query: 977 DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017 WI + + +I+ EN K+L +++Q L+S E+ Sbjct: 2882 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2941 Query: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070 K+ DE + ++ K + L+ MT + + Q+ S +R++Q + + L Sbjct: 2942 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3000 Query: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124 I + + + +T++ Q +K D KRL ++ + E S+ SD+L Sbjct: 3001 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3057 Query: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170 + + E+S L+ ++ E + + E+ Q + ++EL + + Sbjct: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117 Query: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229 E ++Q+ L+K+ A + + ++ E +L +++ +EA +K+ Sbjct: 3118 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3176 Query: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289 + R + E T +R E + K K+ S + QK + EE + E E + Sbjct: 3177 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3232 Query: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349 +Q+ FQK+ E ++Q + N L I A + Sbjct: 3233 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3273 Query: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396 GL+ + D K+ A+ Q + L R + L++ ++ +L +K Sbjct: 3274 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3333 Query: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442 S E + +LL+ LD+ +T+ +K E E+ + A+K +QL L Sbjct: 3334 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3393 Query: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489 + KAE ++ + + + + LE LN EK G +++ Sbjct: 3394 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3453 Query: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537 H E +I + N +H S R++K++ + ++ + +++ Q EKS Sbjct: 3454 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3512 Query: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591 H +LLQ A+ D+++ +N E ++ +++ Q E L +Q +E +++ + Sbjct: 3513 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3572 Query: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646 I +N+ Q + E LK Q G +D+L + TK D Sbjct: 3573 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3625 Query: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705 K LE+ L ++ L S ++ C + ++ E + L E AS+ + R E K + + Sbjct: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3684 Query: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761 + L + L +V L L+ + + + E++ +++ ++ +K+E++ Sbjct: 3685 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3741 Query: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810 E ITE + + L + L+Q+ + AQ ++ +T E+ R Sbjct: 3742 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3799 Query: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 + ++ G + + E +++K+K+D+ +K ++ Sbjct: 3800 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3833 Score = 72.8 bits (177), Expect = 4e-12 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311 +S LL Q L +I + +L+NW++E+ +L + W S+L + E Sbjct: 3515 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3574 Query: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371 L +NV +A+ LK+ E+ L +KL ++++Y + S + + Sbjct: 3575 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3627 Query: 372 LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425 L+ R +T+E + WL++ E E ++Y+ T + + ++ MR EL ++ Sbjct: 3628 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3682 Query: 426 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485 +N K++ + L E A L + +RA + +E+ + E+ + Sbjct: 3683 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3726 Query: 486 NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542 +D T + + AI R D++ + + + + ++ M + L+ T A L + Sbjct: 3727 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3784 Query: 543 GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601 K T+ L+ ++ D +K+ I C + + K D+ VL N + I Sbjct: 3785 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3837 Query: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661 +E + + A L N+ + Y+ L W ++ S + L E Sbjct: 3838 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3887 Query: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718 R + ++ ++ EH+ + + LE S G + EK V + Sbjct: 3888 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3940 Query: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778 Q +++ K A ++ S + ++ I LE +RL + E + + E Sbjct: 3941 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3997 Query: 779 RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835 +I+E + + ++E+L+ T+ + EE +++ + S ++ +L+ ++ ++ Sbjct: 3998 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4057 Query: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886 ++ KL V ++L E C+ ++I + ++ I Sbjct: 4058 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104 Query: 887 -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945 S +KQ + + R+ L++EL + E+ E D K+ D+L W Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4162 Query: 946 QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003 +++ +R+ LE ++ Y+D + DW V+ K+ P + +T+ Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4219 Query: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057 Q+ + K SE +Q +M+ AE V + + M + + DS ++ Sbjct: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4279 Query: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113 + R+ A L + +F A +T L+++ GD K +E E K Sbjct: 4280 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4333 Query: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173 H +D+L Q +TV +K + E + ++ S ++ +L + + +N L Sbjct: 4334 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4386 Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222 K ++ + + A +AK + E+E + + ER L QL + Sbjct: 4387 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4442 Query: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281 E AA E +++ +++ R + D +N+L+++ + +L ++ Sbjct: 4443 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4501 Query: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337 EE L L + +D AE+ L + L + +I ++ N + Sbjct: 4502 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4561 Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397 + T L+ KQ +K + + + K Q + E L+ + Sbjct: 4562 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4621 Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451 E L + L+E+ +L +LE+ K Q +E + L TT + Sbjct: 4622 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4680 Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511 +++E + L + L+L+ + E L+ + D I + ++ F Sbjct: 4681 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4733 Query: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571 D + + + + ++Q L+ N+ D + +EL K + Sbjct: 4734 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4787 Query: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627 LK+ EL + + K+ MQ + E + + Q R EA QA+ F + + Sbjct: 4788 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4847 Query: 1628 TNEHLHKQTKT 1638 E L + +T Sbjct: 4848 LLEWLAEAEQT 4858 Score = 53.9 bits (128), Expect = 2e-06 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%) Query: 260 KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308 KP++K S+ + N + +N + +Q + + D +Q D + G L S+ Sbjct: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207 Query: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368 + + V + IEE + EA +I+M RL Q A+LL + Sbjct: 4208 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4254 Query: 369 ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426 E T+ + + +LIW + EE + +A + HA EL+ L E Sbjct: 4255 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4311 Query: 427 ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486 + +EQ + P + IE + H+ +N Sbjct: 4312 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4345 Query: 487 DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546 EA + N D I+ + S+ +KLE L Q E+ Q K + + +AK Sbjct: 4346 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403 Query: 547 TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600 +Q +++ L S P+ + + + ++ ++ E A + +K + Sbjct: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4461 Query: 601 PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651 G + + P + +D N +++++++V T +E ++ + Sbjct: 4462 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4516 Query: 652 SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710 S IN + + + NVAS +++ + L E +VF+ + Sbjct: 4517 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4562 Query: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766 E+ + + K LK +++ + NL IS ++ R E RL+ + R+ Sbjct: 4563 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4616 Query: 767 PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817 HE+ ++ E ++ L ELE D + T + +EF A SV Sbjct: 4617 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4676 Query: 818 ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856 +L+ + ++ N+ ++ M S DK T+ ++ +N T Sbjct: 4677 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4735 Query: 857 AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913 A +AL+ LY E +L E++ V D + + NLI K ++ E+ ++ AL Sbjct: 4736 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4788 Query: 914 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973 K + E+ + ++ D W K + +L RW+ V ++ LE + + + Sbjct: 4789 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4845 Query: 974 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024 H L +W+ + E T R P++ L T ++Q K + ++E K++++++ Sbjct: 4846 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4895 Score = 40.8 bits (94), Expect = 0.018 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%) Query: 282 VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339 +Q L++W+ ++ QL D+ G D+ V + ++NHK + + + SS++ K S ++ Sbjct: 4737 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4795 Query: 340 -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392 ++ +K+ E R E+ A ++ E L F S L WL E Sbjct: 4796 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4855 Query: 393 EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449 E+ + + + R D H E M++L++K + + + +L HP +T Sbjct: 4856 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915 Query: 450 ---IEAYRAAMQTQWSWILQ 466 I RA + +W Q Sbjct: 4916 KHWITIIRARFEEVLAWAKQ 4935 Score = 40.0 bits (92), Expect = 0.031 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%) Query: 242 SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294 S+G E ++LQ L+++ R K + LD L + + ++DL W+ + + Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421 Query: 295 QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351 L ++ LP + + L H V A E E + K QM A + + Sbjct: 4422 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481 Query: 352 ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394 + ES KL E L+ F + + + WL + E+ Sbjct: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541 Query: 395 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453 + V + E A + + H E + ELD+ ++K + + +L++N Sbjct: 4542 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4591 Query: 454 RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513 ++Q++W ++Q + VE+ R+L DA RK R+ Sbjct: 4592 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4622 Query: 514 IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572 H+ + E +EE E+ L + IAN K KT + Q K K S+ Sbjct: 4623 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682 Query: 573 RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622 R + E T DD L + + R KW I EA++ S FT + Sbjct: 4683 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4740 Query: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682 +D R+E Q + + + M + + E+ + R S+V ++K Sbjct: 4741 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4789 Query: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742 + + E +DS +V +++ + V Q L++A R+ +E + Sbjct: 4790 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4841 Query: 743 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802 S V + L E L P + D L I + ++ K+LE + +L T Sbjct: 4842 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4898 Query: 803 KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862 + + S+ T++ + ++ +V + + + +L + L A + L+ Sbjct: 4899 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4954 Query: 863 KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922 + L E + DK+ + Q EV +E+ + + D++ K Sbjct: 4955 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5009 Query: 923 TYKERDLD 930 TYK R D Sbjct: 5010 TYKRRAAD 5017 >gi|33188445 microfilament and actin filament cross-linker protein isoform a [Homo sapiens] Length = 5430 Score = 1070 bits (2768), Expect = 0.0 Identities = 680/1959 (34%), Positives = 1079/1959 (55%), Gaps = 240/1959 (12%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE+L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI ECE L+ Sbjct: 425 RLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLI 484 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175 RQ +D+QIL D YYQ ++L RV +L+DE++ LR EC T L G Sbjct: 485 RQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKG 530 Query: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235 SL + + PS + T L + +T S TS Sbjct: 531 HFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS---------------- 563 Query: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295 RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++ Sbjct: 564 ---------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMK 602 Query: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355 L+R EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YAE L +LE Sbjct: 603 LERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE 662 Query: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415 +QY KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y Sbjct: 663 TQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYF 722 Query: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475 +EL EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+ Sbjct: 723 SELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHV 782 Query: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535 KENTAYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q K Sbjct: 783 KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842 Query: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595 S++A+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL +NS R K Sbjct: 843 SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902 Query: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655 WKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+Y Sbjct: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962 Query: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715 L ++D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV Sbjct: 963 LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEV 1022 Query: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIR----TPLERD 771 CK +Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I+ + +RD Sbjct: 1023 EACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRD 1082 Query: 772 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831 ++ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M Sbjct: 1083 AWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKM 1142 Query: 832 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891 + VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E STL+ Sbjct: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH 1202 Query: 892 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951 W S+V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ERW V Q Sbjct: 1203 WLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQ 1262 Query: 952 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011 ++ R +LE I + L YR + L WI++ Q ++ Q E+S+ L+ QL+QQ L Sbjct: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTAL 1322 Query: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071 +EIE Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I Sbjct: 1323 FAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAIT 1382 Query: 1072 QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH--------GAYSDLL 1123 QEFMDLRTRYTALVTL TQ++K+ D+L+RLEEEE +E EH G S L Sbjct: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLA 1442 Query: 1124 Q--RQKAT-------------VLENSKLTGKISELERMVAE--------LKKQKSRVEEE 1160 + + KAT +LE L+ +++ + V+E L K ++ E+ Sbjct: 1443 RNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEK 1502 Query: 1161 LPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL 1220 K N L K ++ D S +++ ++ E +T+ +++ ++LE + Sbjct: 1503 EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW 1562 Query: 1221 TIEAEAKRAAVE-ENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRR 1279 +AE A + + L++N + L+D ++ + S + + MEE + Sbjct: 1563 VGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQT 1622 Query: 1280 KRDNEE-----ELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENA 1334 K E E L K+ + L + +VA+K+L+E L+ + ++ EN Sbjct: 1623 KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 1682 Query: 1335 LPVCP---------------ITQATSCRAVTGLQQEHD-----------KQKAEELKQQV 1368 + +T ++G E Q E+L +Q Sbjct: 1683 KKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQC 1742 Query: 1369 DELTAANRK---AEQDMRELTYELNAL--QLEKTSSEEKARLLKDKLDETN--------- 1414 + + A +++ +Q+ T A Q + E+ ++L+ KL E Sbjct: 1743 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 1802 Query: 1415 -----NTLRCLKLELERKDQAEKGYSQQLRELGRQL-NQTTGK----------------A 1452 ++ L+ EL++ Q K + L ++L N G + Sbjct: 1803 SEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS 1862 Query: 1453 EEAMQEASDLKKIKRNYQ--LELESL-----------NHEKGKLQREVDRITRAHAVAEK 1499 E+ + DL+ + + Q L++E+ N K KL+ +R T H+ + Sbjct: 1863 EDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR 1922 Query: 1500 NIQHLN---SQIHSFRDEKELER--LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDK 1554 HLN Q H F++ + + +Q C+ + L S +LQ E Sbjct: 1923 LGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ------EQLAT 1976 Query: 1555 IQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENI-------------- 1600 ++L EEL + E L++ ++ E + +Q +++I Sbjct: 1977 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2036 Query: 1601 -------VLEKQTIQQRCEALKIQADGFKDQ---------LRS--TNEHLHKQTKTEQDF 1642 + + Q++Q+ E+L +Q+ G +Q L S E L K +QD Sbjct: 2037 SSLLQKAIAQSQSVQESLESL-LQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2095 Query: 1643 QRKIKCLEEDLAKSQNLVSEFKQKCDQQN-IIIQNTKKEVRNLNAELNASKEEKRRGEQK 1701 R+ LE ++ +V+ F + D ++Q EV +L ++EK +K Sbjct: 2096 ARQKSSLE----ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151 Query: 1702 VQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL 1761 + Q + L+ +L++ + + + F ++ + E+ ++ ++ L Sbjct: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211 Query: 1762 MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHME 1821 ++TE G LD Q +++ + +KE E+ +EQ+ + + + Sbjct: 2212 --EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKL- 2268 Query: 1822 ANHYQKCQK--------LEDELIAQ--KREVENLKQKMD 1850 +QK K E + A+ ++++E+LK +D Sbjct: 2269 VRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLD 2307 Score = 99.8 bits (247), Expect = 3e-20 Identities = 321/1712 (18%), Positives = 656/1712 (38%), Gaps = 307/1712 (17%) Query: 268 LDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLP-----------SVESHLE 313 L Q T ++ KF+QD +W++ + +L+ G P S + Sbjct: 1807 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI 1866 Query: 314 NHKNVHRAIE-------EFESSLKEAKI-SEIQMTAPLKLTYAEKLHRLESQYAKLLNTS 365 +HK R + + E+S KE K SEI KL A + R + ++K Sbjct: 1867 SHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATE--RYTALHSKCTRLG 1924 Query: 366 RNQERHLDTLHNFVSRATNELIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAEL 418 + L H F + A + W+ E + VA D +A K +L Sbjct: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK----QL 1980 Query: 419 MRELDQKEENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 477 EL + + ++ +Q++A ++ +E PA +R +T S IL Q + + E Sbjct: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPA----PDHRHVQETTDS-ILSHFQSLSYSLAE 2035 Query: 478 NTAYFEFF----NDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LEDLVQESMEEKEEL 531 ++ + +E+ + L +++ + SS+ +++ + +M+ K+++ Sbjct: 2036 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2095 Query: 532 LQYKS-------------------TIANLMGKAKTIIQ------LKPRNSDCPLKTSIPI 566 + KS T A L GK + Q L+ + + LK +P Sbjct: 2096 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2155 Query: 567 KAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLA 626 + ++ ++ + +++ + +GN+ F ++ +L Sbjct: 2156 AEMFEHLSGKLQQFMENKSRML------------ASGNQPDQDITHFF-----QQIQELN 2198 Query: 627 NRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNL 686 +E Q +N+ TL H L+ E+ S+ + +HQ + NL Sbjct: 2199 LEMEDQQENLDTLEH--------------LVTEL-----SSCGFALDLC--QHQDRVQNL 2237 Query: 687 QSRFEDFLEDSQESQVFSGSDITQLE---KEVNVCKQYYQEL----------LKSAEREE 733 + F + + +E + + S QL+ K V +++ +E + + E E+ Sbjct: 2238 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2297 Query: 734 QEESVYNLYISEVRNIRLRLE-NCE----DRLIRQIRTPLERD-------DLHESVFRIT 781 Q E + +L L E NC+ + LI +I P + + SV + Sbjct: 2298 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2357 Query: 782 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841 K +L ++ D+ + K E+ + + L +L M +V+ +++ Sbjct: 2358 GYHTCK-DLTEIQCDMSDVNLKYEKL------GGVLHERQESLQAILNRMEEVHKEANSV 2410 Query: 842 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901 + L++ VLK+ A + K E V A + + ++ L+Q Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAELEQ---------- 2452 Query: 902 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961 ++QK K + TY +W K + ++L RW+ R R LE Sbjct: 2453 ----NSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ-EELNSRWERATEVTVARQRQLEE 2507 Query: 962 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021 L ++ L W+ + E + + + L Q Q + ++ E E ++ + Sbjct: 2508 SASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM-LNAQKQQVQFMLKEFEARRQQ 2566 Query: 1022 MDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY 1081 ++ + A+ D L T + + S + V+ +S I + + T+Y Sbjct: 2567 HEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQY 2626 Query: 1082 TALVTLMTQYIKFAGDSLK-----RLEEEEIKR-CKETSEHGAYSDLLQRQKATVLENSK 1135 L+ +++ ++ G L + E +K+ +ETSE SDL Q V E Sbjct: 2627 QELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE--IRSDLEQLDHE-VKEAQT 2683 Query: 1136 LTGKISEL---ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESE 1192 L ++S L + + ELKK+ V L + + A + + + Q + + + Sbjct: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQA--------ALASTQQ 2735 Query: 1193 AKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTL 1252 +Q EL T + +K++ + AK + L ++QL+EN +++L Sbjct: 2736 FQQMFDELRTWLDDKQSQQ--------------AKNCPISAKLERLQSQLQENEEFQKSL 2781 Query: 1253 EDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEK 1312 H ++ + + E LL + E EK+ + Sbjct: 2782 NQHSGSYEVIVAE------------------GESLLLSVPPGE----------EKRTLQN 2813 Query: 1313 QKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELT 1372 Q +EL+ + + R++ L C QKA++ + V++L Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDC-------------------MQKAQKYQWHVEDLV 2854 Query: 1373 AANRKAEQDMRELTYELNALQLEKTSSEEKARL----LKDKLDETNNTLRCLKLELERKD 1428 + M EL L+ +QLE + KA L + L E N+ + + D Sbjct: 2855 PWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD 2914 Query: 1429 Q-----AEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKL 1483 + + G +Q + + +L TG EE Q + ++ +N + ++E H Sbjct: 2915 EDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKH----- 2969 Query: 1484 QREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQ 1543 Q E+ + A + KN++ L +Q E LQ + + D+L+ + Sbjct: 2970 QLEIFDALGSQACSNKNLEKLRAQ---------QEVLQALEPQVDYLRNFTQGL------ 3014 Query: 1544 NIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQ-RIQAESENIVL 1602 ++ + +D Q L++ AE+ +Q+ E+ ++ N +MM+ +++ + Sbjct: 3015 -VEDAPDGSDASQLLHQ--------AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3065 Query: 1603 EKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSE 1662 ++ Q + L + DG R T + L Q + + F KI L+ D+ S+ +E Sbjct: 3066 VREMFSQLAD-LDDELDGMGAIGRDT-DSLQSQIEDVRLFLNKIHVLKLDIEASE---AE 3120 Query: 1663 FKQKCDQQNII-IQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQD 1721 + +++ + + K+E+ LN + E + +++++L +V++ +LK + D Sbjct: 3121 CRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180 Query: 1722 ELHLKTIEEQM---THRKMVLFQEESGKFKQSAEEFRKKME-KLMESKVITENDISGIRL 1777 E + ++ + ++ FK +E ++ KL + + + I Sbjct: 3181 ATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3240 Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIA 1837 D E+ + NA+ N K++ +++ Q +E + H K Q + L++ Sbjct: 3241 DCDVQGLEHDMEEINARWNTLN-KKVAQRIAQLQEALL--------HCGKFQDALEPLLS 3291 Query: 1838 QKREVENLKQKMDQQIKEHEHQLVLLQCEIQK 1869 + E L +Q+ E+++V Q + QK Sbjct: 3292 WLADTEEL--IANQKPPSAEYKVVKAQIQEQK 3321 Score = 78.6 bits (192), Expect = 8e-14 Identities = 291/1508 (19%), Positives = 577/1508 (38%), Gaps = 218/1508 (14%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD------------RTEWGSDLPSVESH 311 K++LLDQ L+ + + ++LNW+ E++ +L + L E Sbjct: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545 Query: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371 + KNV +AI+ ++ LK+ E+ L EKL ++++YA + TS R Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEV-------LLIQEKLDGIKTRYADITVTSSKALRT 3598 Query: 372 LDTLHNFVSR--ATNELI--WLNEKEEE-EVAYDWSERNTNIARKKDYHAELMRELDQKE 426 L+ ++ +T E + WL E EEE + S I + + EL +E+ + Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658 Query: 427 ENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWI--------------LQLCQCV 471 + +V E++ LL L AR ++ + Q+ + +Q Q Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718 Query: 472 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531 EQ A+ A +R +D + ++ SI D+++ + +EL Sbjct: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI----DIIRHK-DSMDEL 3773 Query: 532 LQYKSTIANLMG-KAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANN 590 ++S I G + KT++Q K ++ ++ I + R + + + N Sbjct: 3774 FSHRSEIFGTCGEEQKTVLQEK---TESLIQQYEAISLLNSERYARL-----ERAQVLVN 3825 Query: 591 SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSV 650 ++ +SP E ++ +P P A+D ++ QQ + + L +S+ Sbjct: 3826 QFWETYEELSPWIEETR--ALIAQLPSP---AID-HEQLRQQQEEMRQL-------RESI 3872 Query: 651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710 I+++ +I +K + P E + V +E + + Q Sbjct: 3873 AEHKPHIDKLLKIG----PQLKELNPEEGEMV---------------EEKYQKAENMYAQ 3913 Query: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLER 770 +++EV Q L E Q + + ++ + LEN RL P E Sbjct: 3914 IKEEVR------QRALALDEAVSQSTQITEFH-DKIEPMLETLENLSSRLRMPPLIPAEV 3966 Query: 771 DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVV 827 D + E I++ + ELE+L+ + + EE ++ + + ++ +L+ + Sbjct: 3967 DKIREC---ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4023 Query: 828 LQNMNQVYSMSS----TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883 + + + + ++D L+ + A +K + + + E+ D + I+ Sbjct: 4024 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIK 4083 Query: 884 NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943 + + + E D L +EL+ + + ++ E + ++ D++ Sbjct: 4084 QQVEAAETIKEETD-------GLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNN 4134 Query: 944 RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTL 1001 W+N++ RL LE ++ Y+DT + DW+ + T K+ P + T+ Sbjct: 4135 AWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL---DNTVIKLCTMPPVGTDLNTV 4191 Query: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAE-----QYSATVKDYELQTMT-YRAMVDSQQK 1055 QLN+ K E+ +Q +M++ E T +D + +T + + ++ + Sbjct: 4192 KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE 4251 Query: 1056 SPVKRRRMQSSADLIIQEFM----DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK 1111 R+ A L + +F +L + T L+ +GD K +E E K Sbjct: 4252 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDP-KVIEVELAK--- 4307 Query: 1112 ETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENE 1171 H +D+L Q ATV +K ++ E + S + L + + E+ Sbjct: 4308 ---HHVLKNDVLAHQ-ATVETVNKAGNELLE-----SSAGDDASSLRSRLEAMNQCWESV 4358 Query: 1172 LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAV 1231 L+K + + + +A+ + E+E + E E +L A + Sbjct: 4359 LQKTEEREQQLQ----STLQQAQGFHSEIEDFLLELTRMESQL--------SASKPTGGL 4406 Query: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI 1291 E R QL+ T L LK K+ + N L K +LM R + + + + Sbjct: 4407 PETA---REQLD----THMELYSQLKAKEETYNQL-LDKGRLMLLSRDDSGSGSKTEQSV 4458 Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351 +E+ V+ K + K K+E EA TE Q + +E + Q+ + + Sbjct: 4459 ALLEQK---WHVVSSKMEERKSKLE-EALNLATEFQNSLQEFINWLTLAEQSLNIASPPS 4514 Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNAL--QLEKTSSEEKARLLKDK 1409 L + EE K +E+ A R+ EL+ QL+ S ++ L+K+ Sbjct: 4515 LILNTVLSQIEEHKVFANEVNA--------HRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566 Query: 1410 LDETNNTL-RCLKLELERKDQAE------KGYSQQLRELGRQLNQTTGKAEEAMQEASDL 1462 L + + ++ +ER + K + + ++L L + ++ ++D Sbjct: 4567 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 4626 Query: 1463 KKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNI-----QHLNSQIHSFRDE--- 1514 KIK E GK I A+ EK + Q L++ + RD+ Sbjct: 4627 DKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDT 4686 Query: 1515 ---KELER-------LQICQRKSDHLK---EQFEKSHEQLLQNIKAEKENN------DKI 1555 K +ER L + D L+ + K QL ++ + + D Sbjct: 4687 VCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAH 4746 Query: 1556 QRLNEELEKSNECAEMLKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRC 1611 + +EL K ++LK+ EL + + K +Q + + + + Q R Sbjct: 4747 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRL 4806 Query: 1612 EALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV---SEFKQKCD 1668 E QA+ F+D + E L + +T R L +D Q+L+ EF +K + Sbjct: 4807 EQALKQAEVFRDTVHMLLEWLSEAEQT----LRFRGALPDDTEALQSLIDTHKEFMKKVE 4862 Query: 1669 QQNIIIQN 1676 ++ + + + Sbjct: 4863 EKRVDVNS 4870 Score = 73.2 bits (178), Expect = 3e-12 Identities = 364/1945 (18%), Positives = 733/1945 (37%), Gaps = 293/1945 (15%) Query: 242 SSGVEPNSLQTLKLMQIRKPL--LKSSLLD---QNLTEEEINMKFVQDLLNWVDEMQVQL 296 + G P + ++ ++ K + LKS L D + EEIN K L N + E+ Sbjct: 2279 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS-LENLIMEITAPD 2337 Query: 297 DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT-APLKLTYAEK---LH 352 + + GS LPSV S + + H + ++EIQ + + L Y + LH Sbjct: 2338 SQGKTGSILPSVGSSVGSVNGYHTCKD----------LTEIQCDMSDVNLKYEKLGGVLH 2387 Query: 353 RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 412 + +LN R +E H + A + L WL KEE + D T K Sbjct: 2388 ERQESLQAILN--RMEEVHKE--------ANSVLQWLESKEEVLKSMDAMSSPTKTETVK 2437 Query: 413 DYHAELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQ---TQWSWILQL 467 L + E+N +Q++ E L LL +P E ++ + ++W ++ Sbjct: 2438 AQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV 2497 Query: 468 CQCVEQHIKENTAYFEFFNDAK-EATDYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQES 524 ++ ++E+ ++ F A+ + +L + L + S D + ++ + VQ Sbjct: 2498 TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSID-PNMLNAQKQQVQFM 2556 Query: 525 MEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ--IEITIYKD 582 ++E E Q + +A I P D L TS K + Q +E+T + Sbjct: 2557 LKEFEARRQQHEQL----NEAAQGILTGP--GDVSLSTSQVQKELQSINQKWVELTDKLN 2610 Query: 583 ------DECVLANNSHRAKWKVISP----TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQ 632 D+ ++ + ++ + +S G V S T P K+ ++ + I Sbjct: 2611 SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD 2670 Query: 633 YQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFED 692 + L HE A + ++L GE Q + L+ R E Sbjct: 2671 LEQ---LDHEVK-------------------EAQTLCDELSVLIGE-QYLKDELKKRLET 2707 Query: 693 FLEDSQESQVFSGSDITQLEKEVNVCKQYYQ--ELLKSAEREEQEESVYNLYISEVRNIR 750 Q + + I +L+ + +Q+ Q + L++ ++Q + N IS Sbjct: 2708 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA----- 2762 Query: 751 LRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ 810 +LE + +L E E+ +K L + I + E Sbjct: 2763 -KLERLQSQL--------------------QENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801 Query: 811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT-VNLVLKNTQAAEALVKLYETKL 869 TL+++L + + ++ ++ +LK + K E LV E Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861 Query: 870 CE--EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKER 927 + E V D +E+ + K +EV+++R + L + +D + + Sbjct: 2862 AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN-------SAADILINS---S 2911 Query: 928 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987 + D D +++ + + V ++ + LE + + L+ +++++ ++ ++VE + Sbjct: 2912 EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE---KKVEGAK 2968 Query: 988 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1047 +++ + L Q +E +++ + Q Q DY L+ T Sbjct: 2969 HQLE---------IFDALGSQACSNKNLEKLRAQQEVLQALEPQV-----DY-LRNFTQG 3013 Query: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEI 1107 + D+ S + Q A++ QEF++++ R + +M ++ G R+ E Sbjct: 3014 LVEDAPDGSDASQLLHQ--AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREM-- 3069 Query: 1108 KRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREA 1167 S+ D L A + L +I ++ + ++ K +E + R Sbjct: 3070 -----FSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHM 3124 Query: 1168 AENE----LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI- 1222 E E L +R +E ++ Q + K + +LE + E R+L+ + T Sbjct: 3125 LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTA 3184 Query: 1223 --EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQ---QKNKLMEEL 1277 EAEA + V + QL + ++ D L+ K +N L Q Q ++ Sbjct: 3185 AEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDV 3244 Query: 1278 RRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPV 1337 + + EE+ + K +A + ++ L K + ++ + T A Sbjct: 3245 QGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQK 3304 Query: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ-----DMRELTYELNAL 1392 P + +A +Q+ ++ ++ K VD L A + Q D ++T +L +L Sbjct: 3305 PPSAEYKVVKAQIQ-EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363 Query: 1393 QLEKTSSEEKARLLKDKLD----------ETNNTLRCLKLELERKDQAEKGYSQQLRELG 1442 + T KA + +L+ ET + E+K + Q ++ Sbjct: 3364 ESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQ 3423 Query: 1443 RQLNQTTGKAEEAMQEASDLKK-IKRNYQLELESLNHEKGKLQREVDRITRAHAVAE--- 1498 +Q+ + E+ A+D+ + +K L + E+G L ++D + ++ + Sbjct: 3424 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3483 Query: 1499 -KNIQHLNSQIHSFR--DEKELERLQICQRKSDHLKEQFEKSHEQ------------LLQ 1543 + L+ + + R E E+E L D L F K +Q L + Sbjct: 3484 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 3543 Query: 1544 NIKAEKENNDKI---------QRLNEELEKSNECAEMLKQKVEELT-------RQNNETK 1587 I K+N D+ Q EE+ E + +K + ++T R + + Sbjct: 3544 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 3603 Query: 1588 LMMQRIQAESENIV-----LEKQT---------------IQQRCEALKIQADGFKDQLRS 1627 + + Q+ E + +E++ QQR + LK + + L + Sbjct: 3604 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 3663 Query: 1628 TNEHLHKQTKTEQDFQRK-IKCLEEDLAKSQNLVSE-FKQKCDQQNIIIQNTKKEVRNLN 1685 NE + R+ + L D + LVS+ Q+ D+ + IQ +++ + + Sbjct: 3664 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723 Query: 1686 AELNASKEEKRR----GEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF- 1740 AEL E KR+ G +++ Q Q + + H +++E +HR + Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 3783 Query: 1741 --QEESGKFKQSAEEFRKKME--KLMESKVITENDISGIRLD-FVSLQQENSRAQENAKL 1795 +E+ ++ E ++ E L+ S+ + + + ++ F +E S E + Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843 Query: 1796 CETNIKEL---ERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM-DQ 1851 + QL+Q +E+M+Q + A H KL ++ Q +E+ + +M ++ Sbjct: 3844 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-KIGPQLKELNPEEGEMVEE 3902 Query: 1852 QIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 + ++ E+ ++ E+++++ A D E S++T + Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALD------------------EAVSQST---------QI 3935 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFD 1971 + + +P+ E +E + ++ PP P E +K ++C S+ S T EL+ Sbjct: 3936 TEFHDKIEPMLE-----TLENLSSRLR-MPPLIPAEVDKIRECISDNKSAT-VELEKLQP 3988 Query: 1972 ETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMEL-------------VKVLTPLEIA 2018 + R E R Q + QD +M +K L LE+A Sbjct: 3989 SFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELA 4048 Query: 2019 KNKQYDMHTEVTTLKQEKNPVPSAE 2043 + YDM +TT+K ++ V E Sbjct: 4049 EKFWYDMAALLTTIKDTQDIVHDLE 4073 Score = 70.5 bits (171), Expect = 2e-11 Identities = 294/1718 (17%), Positives = 668/1718 (38%), Gaps = 256/1718 (14%) Query: 349 EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408 E R+E Y K++ + + H++T + + W +++ ++ W+ Sbjct: 931 EMASRVEQSYQKVM--ALWHQLHVNT--------KSLISWNYLRKDLDLVQTWNLEKLRS 980 Query: 409 ARKKDYHAELMRELDQKEENIKS------VQEIAEQLLLENHPARLTIEAYRAAMQTQWS 462 + + H ++M+ L E+ + +A++L LE +EA +A Q Sbjct: 981 SAPGECH-QIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEE-----VEACKARFQ---- 1030 Query: 463 WILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LED- 519 L + +E KE T + ++ K L + + ++ SS + +D Sbjct: 1031 ---HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDN 1087 Query: 520 --LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP------------------ 559 + E +E+L Q +S + + K + + P +S P Sbjct: 1088 ALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYG 1147 Query: 560 --------LKT-SIPIKAICDYRQI----EITIYKDDECVLANNSHRAKWKVI----SPT 602 LKT + +++I D + EI + +++ + ++ A W + S Sbjct: 1148 LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDV 1207 Query: 603 GNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 662 ++ V SV K + +R+ + L + E ++ WH +I +++ Sbjct: 1208 KDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQE--RWHRVIAQLE- 1264 Query: 663 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYY 722 IR S + SI+ +L G+++ L E+ + + D L ++++ + Sbjct: 1265 IRQSELESIQEVL-GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALF 1323 Query: 723 QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITE 782 E+ ++ + +Q + Y + V++ L+L + + Q ++P +R + S IT+ Sbjct: 1324 AEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQ 1383 Query: 783 QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI 842 + +L L T+T + ++ S A + L E VV + + ++ Sbjct: 1384 EFM---DLRTRYTALVTLTTQHVKYISDA-----LRRLEEEEKVVEEEKQE-------HV 1428 Query: 843 DKLKT----VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDE 898 +K+K V+ + +NTQ + E+ + E I ++ + ++T K+ SE + Sbjct: 1429 EKVKELLGWVSTLARNTQGKATSSETKEST--DIEKAILEQQVLSEELTTKKEQVSEAIK 1486 Query: 899 KRQVF---HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955 Q+F H + ++ K IS+++ K + + D + Q + Q+ ++ Sbjct: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKA-------YHDLCDGSANQLQQLQSQLAHQ 1539 Query: 956 LRDLEGIGKSLKYYRDTYHP-LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014 K+L+ ++T H L+D V +R + +Q ++ + L + + + + Sbjct: 1540 TEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKD 1594 Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074 ++ D+ Q A ++ VKD E + + ++ + ++ + Q+ E Sbjct: 1595 LQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY---EA 1645 Query: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LEN 1133 + TR + + ++ A S + E E+ K KE +E+ D L +V Sbjct: 1646 LQEETR------VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699 Query: 1134 SKLTGKISELERMV-AELKKQK----------SRVEEELPK---VREAAENELRKQQRNV 1179 +L + +E++ A L+K ++ E+L K + +A EL QQ+N Sbjct: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQN- 1758 Query: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR 1239 L A++ Q+ L E++ +++L +++ + A+ A + + + Sbjct: 1759 --FILATQSAQAFLDQHGHNLTP--EEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ 1814 Query: 1240 NQLEENTFTRRTLEDHLKRKDLSLNDLEQ---QKNKLMEELRRKRDNEEELL-------- 1288 ++L++ + E L+R + L ++ + L L+R+ E+++ Sbjct: 1815 DELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRF 1874 Query: 1289 -----KLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPI--- 1340 + + ME K+ +E K K++ +A + T + C + + Sbjct: 1875 VTISGQKVLDMENSFKEGKEPSEIGNLVKDKLK-DATERYTALHSKCTRLGSHLNMLLGQ 1933 Query: 1341 -----TQATSCRA-VTGLQQEHDKQKAEELKQQ---VDELTAANRKAEQDMRELTYELNA 1391 A S +A + + +K ++ + + E A ++ ++++ E +++ Sbjct: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE--HQVPV 1991 Query: 1392 LQLEKTSSE------EKA---RLLKDKLDETNNTLRCLKLEL-ERKDQAEKGY--SQQLR 1439 +L+K + + E A R +++ D + + L L ER +K SQ ++ Sbjct: 1992 EKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQ 2051 Query: 1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEK 1499 E L Q+ G+ E+ + E + + E + N KL++++ R + Sbjct: 2052 ESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATNM---KLKQDIAR-------QKS 2100 Query: 1500 NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLN 1559 +++ + F + + + Q K + ++FE+ Q ++E +++L Sbjct: 2101 SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ-------QQEKESSLKKLL 2153 Query: 1560 EELEKSNECAEMLKQKVEELTRQ---NNETKLMMQRIQAESENIVLEKQTIQQRCEALK- 1615 + E + L+Q +E +R N+ + + + + LE + Q+ + L+ Sbjct: 2154 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH 2213 Query: 1616 ----IQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQN 1671 + + GF L + + K + Q+ +K E+D + Q + EF++ Sbjct: 2214 LVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQ 2273 Query: 1672 IIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQ 1731 ++ T+ + ++A + EK Q++ L + L D T+ E+ Sbjct: 2274 KWLKETEGSIPPTETSMSAKELEK------------QIEHLKSLL---DDWASKGTLVEE 2318 Query: 1732 MTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL--DFVSLQQENSRA 1789 + + L E+ + +A + + K ++ S + ++G D +Q + S Sbjct: 2319 INCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2375 Query: 1790 QENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849 + + E + LQ +M++ H EAN + + ++E++ + M Sbjct: 2376 NLKYEKLGGVLHERQESLQAILNRMEE-VHKEANSVLQWLESKEEVL----------KSM 2424 Query: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRS 1909 D + + V Q E K F + E + Q ++ G L P S Sbjct: 2425 DAMSSPTKTETVKAQAESNK-------AFLAELEQNSPKIQ---KVKEALAGLLVTYPNS 2474 Query: 1910 -PLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPL 1946 W + + L +W+ + ++ Q + + L Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHL 2512 Score = 66.6 bits (161), Expect = 3e-10 Identities = 233/1166 (19%), Positives = 424/1166 (36%), Gaps = 235/1166 (20%) Query: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVVLQNMNQVYSMS 838 T+ K+++++ R K I N + S+ +L S E V+ + ++ + + Sbjct: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARY 3476 Query: 839 STYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST-LKQWRSEVD 897 S D+ +L + L E ++ A + DK L S +K ++ +V Sbjct: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK-----LSSVFVKDFKQDVL 3531 Query: 898 EKRQVFH-ALEDELQKAKAISDEMFK--------TYKERDLDFDWHKEKADQLVERWQNV 948 ++ H AL +E+ K D+ K T E L +EK D + R+ ++ Sbjct: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI---QEKLDGIKTRYADI 3588 Query: 949 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR-------------KIQENQP 995 V LR LE + ++ TY L W+++VE + Q+ Q Sbjct: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQK 3648 Query: 996 ENSK--------------------------------TLATQLNQQKMLVSE-IEMKQSKM 1022 E K L + N+Q LVS+ I + ++ Sbjct: 3649 ELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEI 3708 Query: 1023 DECQKYAEQYSATVKDYELQTM--TYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL--- 1077 D + ++QY D EL + T R ++ P++ + Q++A L +Q+ + Sbjct: 3709 DAAIQRSQQYEQAA-DAELAWVAETKRKLM---ALGPIRLEQDQTTAQLQVQKAFSIDII 3764 Query: 1078 --RTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSK 1135 + L + ++ G+ K + +E+ + L+Q+ +A L NS+ Sbjct: 3765 RHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE------------SLIQQYEAISLLNSE 3812 Query: 1136 LTGKISELERMVAELKKQKSRVEEELPKVREAA------------ENELRKQQRNV---- 1179 + + LER + + EE P + E +LR+QQ + Sbjct: 3813 ---RYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 3869 Query: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERVR----QLTIEAEAKRAAVEE-- 1233 E I+ K + K + E E E E + ++ Q+ E + A++E Sbjct: 3870 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 3929 Query: 1234 ----NLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289 + F +++E T L L+ L + + +K+ E + + EL K Sbjct: 3930 SQSTQITEFHDKIEPMLETLENLSSRLRMPPL----IPAEVDKIRECISDNKSATVELEK 3985 Query: 1290 L------IKQMEKDLAFQKQVAEKQLKEKQ---KI--------ELEARRKITEIQYTCRE 1332 L +K+ ++L + Q A+K L K+ K+ +++AR + EI++ Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045 Query: 1333 NALPVCPITQATSCRAVTGLQQ-EHDKQK----AEELKQQVDELTAANRKAEQDMRELTY 1387 A + Q HD + +KQQV+ + + EL + Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105 Query: 1388 -ELNALQLEKTSSEEKARLLKDKLDETNNTLRCL------KLE-LERKDQAEKGYSQQLR 1439 + L E + ++ +DE NN L +LE LE QA Y L+ Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQ 4165 Query: 1440 ELGRQLNQTTGK-------------AEEAMQEASDLKKIKRNYQLELESLNHE-KGKLQR 1485 + L+ T K ++ + E + K Q+E+E LNH+ + L++ Sbjct: 4166 AMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKK 4225 Query: 1486 EVDRITR---------------------AH--------AVAEKNIQHLNSQIHSF----- 1511 D R AH +A QH ++ S+ Sbjct: 4226 ATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE 4285 Query: 1512 ----------RDEK--ELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLN 1559 D K E+E + K+D L Q N E D L Sbjct: 4286 ELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLR 4345 Query: 1560 EELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQAD 1619 LE N+C E + QK EE +Q T Q +E E+ +LE ++ + A K Sbjct: 4346 SRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK-PTG 4404 Query: 1620 GFKDQLR---STNEHLHKQTKTEQDF------QRKIKCLEED----LAKSQNLVSEFKQK 1666 G + R T+ L+ Q K +++ + ++ L D +K++ V+ +QK Sbjct: 4405 GLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4464 Query: 1667 CDQQNIIIQNTK---KEVRNLNAELNASKEE----KRRGEQKVQLQQAQVQELNNRLKKV 1719 + ++ K +E NL E S +E EQ + + LN L ++ Sbjct: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 4524 Query: 1720 QDELHLKTIEEQMTHRKMVLFQEESG 1745 ++ H E HR ++ +++G Sbjct: 4525 EE--HKVFANEVNAHRDQIIELDQTG 4548 Score = 45.1 bits (105), Expect = 0.001 Identities = 157/917 (17%), Positives = 328/917 (35%), Gaps = 155/917 (16%) Query: 1116 HGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQ 1175 H +Y++ L + + + KL S R + L K SR EL + E E EL Sbjct: 651 HTSYAETLGKLET---QYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYD 707 Query: 1176 -QRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL-TIEAEAKRAAVEE 1233 N +IS ++ Y EL + EK+ R L+ +L ++E + VE Sbjct: 708 WSDNNSNISAKR--------NYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEA 759 Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRKDL------SLNDLEQQKNKLMEELRRKRDNEEEL 1287 ++QL+ +E H+K +LE L + ++RK + Sbjct: 760 YSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNT 819 Query: 1288 LKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR 1347 + ++E L E+ ++ K + R T +Q R P + S + Sbjct: 820 S--LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRS---PDHVLKNTISVK 874 Query: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLK 1407 AV +Q E+T + LE S K +++ Sbjct: 875 AVCDYRQI--------------EITICKN-------------DECVLEDNSQRTKWKVIS 907 Query: 1408 DKLDETNNTLRCLKLELERKD------QAEKGYSQQLRELGRQLNQTTGKAEEAMQEASD 1461 +E C + KD + E+ Y Q++ L QL+ T D Sbjct: 908 PTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY-QKVMALWHQLHVNTKSLISWNYLRKD 966 Query: 1462 LKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL-NSQIHSFRDEKELER- 1519 L ++ LE L ++ + +AH E +Q +S + S D LE Sbjct: 967 LDLVQT---WNLEKLRSSAPGECHQIMKNLQAHY--EDFLQDSRDSVLFSVADRLRLEEE 1021 Query: 1520 LQICQRKSDHLKEQFE-KSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEE 1578 ++ C+ + HL + E + E+ + + + N +++ E + + + Sbjct: 1022 VEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDR 1081 Query: 1579 LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTN--------- 1629 Q+N ++ AE E+ + Q ++ +A+ ++ D F Q S++ Sbjct: 1082 DAWQDNALRI------AEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135 Query: 1630 -------EHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK---- 1678 +H++ + + + + + + ++ LV ++ K Q+ +++ + Sbjct: 1136 NLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195 Query: 1679 ---------KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKK-------VQDE 1722 +V++ N+ + EE + + + E N L++ +Q+ Sbjct: 1196 HWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQER 1255 Query: 1723 LHLKTIEEQMTHRKMVLFQEESGKFKQ------------SAEEFRKKMEKLMESKVITEN 1770 H + ++ ++ QE G ++ +A++ K + +S+V++E Sbjct: 1256 WHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQ 1315 Query: 1771 DISGIRLDFVSLQQENSRAQENAKLCE---TNIKELERQLQQYREQMQQGQH-------- 1819 +S F +++ ++ + K + T +K+ E QL Y+ ++ Q Sbjct: 1316 -LSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRM 1374 Query: 1820 -----------------------MEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEH 1856 + H + L +++ VE KQ+ +++KE Sbjct: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKEL 1434 Query: 1857 EHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQ 1916 + L Q K+T+ + D E + E Q E + + ++ + + Sbjct: 1435 LGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAK 1494 Query: 1917 EPQPLEEKWQHRVVEQI 1933 L EK + ++ EQ+ Sbjct: 1495 HGHKLSEKEKKQISEQL 1511 Score = 39.3 bits (90), Expect = 0.052 Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322 K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + + Sbjct: 4802 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 4861 Query: 323 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377 EE + A + E+ + T + + +++ ++L ++ ++ L+T L Sbjct: 4862 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 4921 Query: 378 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431 V+ A L W+ E + D NI R K H M E+ +K+ ++ Sbjct: 4922 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 4981 Query: 432 VQEIAEQLLLE 442 V + ++ +E Sbjct: 4982 VTKTYKRKNIE 4992 Score = 36.2 bits (82), Expect = 0.44 Identities = 50/224 (22%), Positives = 101/224 (45%), Gaps = 16/224 (7%) Query: 279 MKFVQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS- 335 M +Q L++W+ +++ QL D+ G DL V + ++ HK + + + +++ K S Sbjct: 4709 MDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 4767 Query: 336 -EIQMTAPLKLTYAE-KLHRLESQYAKLLNTSRNQERHLDTL--HNFVSRATNELI--WL 389 E+ + T+ + +L L +++ + S +++ L+ V R T ++ WL Sbjct: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827 Query: 390 NEKEEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448 +E E+ +T + D H E M+++++K ++ S + E +L HP + Sbjct: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 4887 Query: 449 T-----IEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487 T I RA + +W Q Q +E + E A E + Sbjct: 4888 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEE 4931 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1415 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1833 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1890 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2189 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2190 TLRLQLEETDHQKNLLDEELQR 2211 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1168 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1226 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1273 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1274 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1332 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1565 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1566 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1623 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1855 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2094 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2206 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2267 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2322 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2323 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2381 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2438 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2439 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2676 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2736 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2737 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2796 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2856 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2857 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2916 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 2917 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2975 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 2976 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3022 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 3023 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3080 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3081 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3140 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3141 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3200 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3201 PDQLTGLSLLPLSE 3214 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3819 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3870 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 3871 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3919 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 3920 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3979 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 3980 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4160 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4219 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4220 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4279 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4280 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4339 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4340 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4399 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4400 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4459 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4460 GLRLLEAAAQSTKGYYSPY 4478 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3297 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3356 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3357 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3416 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3417 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3476 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3477 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3536 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3537 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3594 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3595 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3653 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3654 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3709 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3710 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3769 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3770 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3829 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3830 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3879 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 2974 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3033 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3034 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3093 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3094 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3153 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3154 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3213 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3214 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3256 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3257 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3308 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3309 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3368 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3369 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3428 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3429 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3488 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3489 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3541 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3643 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3702 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3703 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3762 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3763 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3822 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3823 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3881 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 3882 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3941 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 3942 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3997 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 3998 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4160 KGLIDHQTYLELSEQE 4175 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2660 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2717 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2718 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2777 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2778 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2837 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2838 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2897 Query: 2648 SS 2649 S Sbjct: 2898 DS 2899 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 390 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 449 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 450 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 522 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 582 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 642 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 702 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 762 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 822 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 882 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 942 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1300 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1360 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1419 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1539 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1540 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1837 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1894 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2193 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2194 TLRLQLEETDHQKNLLDEELQR 2215 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1172 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1229 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1230 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1277 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1278 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1335 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1336 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1512 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1569 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1570 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1627 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1682 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1683 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1742 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1859 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2098 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2210 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2271 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2326 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2327 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2385 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2442 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2443 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2621 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2680 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2681 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2740 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2741 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2800 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2801 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2860 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2861 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2920 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 2921 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2979 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 2980 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3026 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 3027 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3084 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3085 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3144 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3145 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3204 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3205 PDQLTGLSLLPLSE 3218 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3823 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3874 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 3875 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3923 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 3924 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3983 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 3984 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4043 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4044 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4103 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4104 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4163 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4164 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4223 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4224 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4283 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4284 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4343 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4344 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4403 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4404 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4463 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4464 GLRLLEAAAQSTKGYYSPY 4482 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3301 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3360 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3361 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3420 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3421 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3480 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3481 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3540 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3541 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3598 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3599 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3657 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3658 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3713 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3714 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3773 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3774 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3833 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3834 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3883 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 2978 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3037 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3038 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3097 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3098 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3157 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3158 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3217 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3218 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3260 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3261 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3312 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3313 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3372 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3373 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3432 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3433 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3492 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3493 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3545 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3647 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3706 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3707 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3766 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3767 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3826 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3827 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3885 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 3886 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3945 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 3946 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 4001 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 4002 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4043 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4044 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4103 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4104 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4163 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4164 KGLIDHQTYLELSEQE 4179 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2664 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2721 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2722 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2781 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2782 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2841 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2842 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2901 Query: 2648 SS 2649 S Sbjct: 2902 DS 2903 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 394 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 453 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 454 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 491 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1415 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1833 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1890 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2189 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2190 TLRLQLEETDHQKNLLDEELQR 2211 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1168 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1226 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1273 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1274 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1332 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1565 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1566 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1623 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1855 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2094 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2206 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2267 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2322 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2323 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2381 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2438 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2439 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2676 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2736 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2737 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2796 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2856 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2857 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2916 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 2917 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2975 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 2976 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3022 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 3023 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3080 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3081 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3140 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3141 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3200 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3201 PDQLTGLSLLPLSE 3214 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3819 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3870 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 3871 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3919 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 3920 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3979 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 3980 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4160 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4219 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4220 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4279 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4280 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4339 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4340 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4399 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4400 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4459 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4460 GLRLLEAAAQSTKGYYSPY 4478 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3297 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3356 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3357 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3416 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3417 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3476 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3477 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3536 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3537 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3594 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3595 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3653 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3654 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3709 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3710 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3769 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3770 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3829 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3830 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3879 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 2974 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3033 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3034 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3093 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3094 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3153 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3154 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3213 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3214 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3256 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3257 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3308 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3309 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3368 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3369 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3428 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3429 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3488 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3489 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3541 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3643 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3702 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3703 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3762 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3763 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3822 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3823 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3881 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 3882 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3941 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 3942 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3997 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 3998 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4039 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4040 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4099 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4100 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4159 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4160 KGLIDHQTYLELSEQE 4175 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2660 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2717 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2718 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2777 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2778 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2837 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2838 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2897 Query: 2648 SS 2649 S Sbjct: 2898 DS 2899 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 390 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 449 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 450 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 486 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 546 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 606 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 666 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 726 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 786 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 846 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 906 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 966 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1264 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1324 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1383 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1801 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1858 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2157 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2158 TLRLQLEETDHQKNLLDEELQR 2179 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1136 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1193 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1194 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1241 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1242 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1299 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1300 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1476 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1477 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1533 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1534 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1591 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1646 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1647 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1706 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1823 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2062 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2174 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2235 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2290 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2291 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2349 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2406 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2407 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2585 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2644 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2645 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2704 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2705 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2764 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2765 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2824 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2825 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2884 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 2885 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2943 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 2944 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 2990 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 2991 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3048 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3049 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3108 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3109 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3168 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3169 PDQLTGLSLLPLSE 3182 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3787 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3838 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 3839 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3887 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 3888 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3947 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 3948 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4007 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4008 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4067 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4068 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4127 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4128 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4187 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4188 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4247 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4248 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4307 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4308 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4367 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4368 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4427 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4428 GLRLLEAAAQSTKGYYSPY 4446 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3265 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3324 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3325 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3384 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3385 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3444 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3445 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3504 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3505 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3562 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3563 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3621 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3622 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3677 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3678 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3737 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3738 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3797 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3798 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3847 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 2942 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3001 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3002 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3061 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3062 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3121 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3122 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3181 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3182 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3224 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3225 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3276 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3277 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3336 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3337 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3396 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3397 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3456 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3457 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3509 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3611 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3670 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3671 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3730 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3731 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3790 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3791 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3849 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 3850 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3909 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 3910 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3965 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 3966 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4007 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4008 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4067 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4068 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4127 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4128 KGLIDHQTYLELSEQE 4143 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2628 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2685 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2686 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2745 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2746 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2805 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2806 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2865 Query: 2648 SS 2649 S Sbjct: 2866 DS 2867 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 358 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 417 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 418 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 455 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1552 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1970 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 2027 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2326 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2327 TLRLQLEETDHQKNLLDEELQR 2348 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1305 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1363 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1410 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1411 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1468 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1469 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1645 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1646 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1702 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1703 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1760 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1815 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1816 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1875 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1992 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2231 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2343 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2404 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2459 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2460 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2518 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2575 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2576 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2754 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2813 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2814 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2873 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2874 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2933 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2934 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2993 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2994 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 3053 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 3054 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 3112 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 3113 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3159 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 3160 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3217 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3218 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3277 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3278 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3337 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3338 PDQLTGLSLLPLSE 3351 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3956 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 4007 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 4008 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 4056 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 4057 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 4116 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 4117 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4176 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4177 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4236 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4237 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4296 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4297 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4356 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4357 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4416 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4417 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4476 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4477 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4536 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4537 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4596 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4597 GLRLLEAAAQSTKGYYSPY 4615 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3434 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3493 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3494 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3553 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3554 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3613 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3614 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3673 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3674 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3731 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3732 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3790 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3791 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3846 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3847 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3906 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3907 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3966 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3967 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 4016 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 3111 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3170 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3171 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3230 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3231 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3290 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3291 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3350 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3351 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3393 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3394 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3445 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3446 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3505 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3506 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3565 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3566 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3625 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3626 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3678 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3780 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3839 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3840 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3899 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3900 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3959 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3960 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 4018 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 4019 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 4078 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 4079 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 4134 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 4135 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4176 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4177 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4236 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4237 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4296 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4297 KGLIDHQTYLELSEQE 4312 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2797 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2854 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2855 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2914 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2915 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2974 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2975 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 3034 Query: 2648 SS 2649 S Sbjct: 3035 DS 3036 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 527 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 586 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 587 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 496 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 556 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 616 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 676 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 736 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 796 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 856 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 916 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 976 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1393 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1811 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1868 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2167 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2168 TLRLQLEETDHQKNLLDEELQR 2189 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1146 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1204 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1251 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1252 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1309 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1310 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1426 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1486 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1487 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1543 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1544 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1600 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1601 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1656 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1657 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1716 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1833 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2072 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2184 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2245 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2300 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2301 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2359 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2416 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2417 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2595 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2654 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2655 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2714 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2715 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2774 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2775 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2834 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2835 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2894 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 2895 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2953 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 2954 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3000 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 3001 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3058 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3059 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3118 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3119 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3178 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3179 PDQLTGLSLLPLSE 3192 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3797 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3848 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 3849 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3897 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 3898 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3957 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 3958 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4017 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4018 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4077 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4078 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4137 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4138 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4197 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4198 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4257 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4258 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4317 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4318 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4377 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4378 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4437 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4438 GLRLLEAAAQSTKGYYSPY 4456 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3275 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3334 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3335 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3394 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3395 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3454 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3455 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3514 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3515 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3572 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3573 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3631 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3632 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3687 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3688 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3747 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3748 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3807 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3808 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3857 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 2952 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3011 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3012 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3071 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3072 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3131 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3132 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3191 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3192 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3234 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3235 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3286 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3287 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3346 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3347 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3406 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3407 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3466 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3467 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3519 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3621 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3680 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3681 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3740 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3741 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3800 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3801 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3859 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 3860 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3919 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 3920 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3975 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 3976 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4017 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4018 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4077 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4078 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4137 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4138 KGLIDHQTYLELSEQE 4153 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2638 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2695 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2696 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2755 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2756 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2815 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2816 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2875 Query: 2648 SS 2649 S Sbjct: 2876 DS 2877 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 368 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 427 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 428 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 504 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 564 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 624 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 684 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 744 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 804 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 864 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 924 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 984 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1282 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1401 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1521 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1522 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1641 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1819 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1820 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1876 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1996 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2056 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2175 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2176 TLRLQLEETDHQKNLLDEELQR 2197 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1154 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1211 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1212 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1259 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1260 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1317 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1318 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1434 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1494 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1495 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1551 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1552 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1608 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1609 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1664 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1841 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2080 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2192 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2253 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2308 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2309 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2367 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2424 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2425 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2662 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2663 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2722 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2723 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2782 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2783 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2842 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2843 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2902 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 2903 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 2961 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 2962 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3008 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 3009 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3066 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3067 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3126 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3127 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3186 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3187 PDQLTGLSLLPLSE 3200 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3805 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3856 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 3857 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3905 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 3906 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3965 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 3966 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4025 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4026 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4085 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4086 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4145 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4146 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4205 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4206 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4265 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4266 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4325 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4326 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4385 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4386 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4445 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4446 GLRLLEAAAQSTKGYYSPY 4464 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3283 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3342 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3343 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3402 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3403 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3462 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3463 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3522 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3523 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3580 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3581 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3639 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3640 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3695 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3696 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3755 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3756 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3815 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3816 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3865 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 2960 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3019 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3020 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3079 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3080 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3139 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3140 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3199 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3200 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3242 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3243 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3294 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3295 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3354 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3355 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3414 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3415 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3474 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3475 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3527 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3629 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3688 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3689 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3748 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3749 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3808 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3809 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3867 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 3868 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3927 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 3928 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 3983 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 3984 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4025 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4026 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4085 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4086 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4145 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4146 KGLIDHQTYLELSEQE 4161 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2646 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2703 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2704 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2763 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2764 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2823 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2824 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2883 Query: 2648 SS 2649 S Sbjct: 2884 DS 2885 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 376 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 435 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 436 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 473 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 923 bits (2385), Expect = 0.0 Identities = 544/1702 (31%), Positives = 962/1702 (56%), Gaps = 115/1702 (6%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264 Query: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323 Query: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383 Query: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1442 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502 Query: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562 Query: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682 Query: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742 Query: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1860 Query: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1917 Query: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977 Query: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2037 Query: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQS--------------------- 1750 + KV++ L+ EQ + R++ L QE + K Q+ Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097 Query: 1751 ------------AEEFRKKMEKLMESKVITENDIS--------GIRLDFVSLQQENSRAQ 1790 AE R+ E+ E++V E + + RL + +Q +RAQ Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157 Query: 1791 ENA---KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQ 1847 A KL + +E R+ Q + ++Q Q +A +K +K ++ + QK +VE Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELT 2216 Query: 1848 KMDQQIKEHEHQLVLLQCEIQK 1869 + Q++E +HQ LL E+Q+ Sbjct: 2217 TLRLQLEETDHQKNLLDEELQR 2238 Score = 431 bits (1108), Expect = e-120 Identities = 488/2114 (23%), Positives = 926/2114 (43%), Gaps = 221/2114 (10%) Query: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE-VNVCKQYYQEL-------LKS 728 GE + + R LE Q V + +D+ Q E E + +YY+E L+ Sbjct: 1195 GERDVEVERWRERVAQLLERWQA--VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 788 A R ++E + + +++ + +R +L RQ + LE + H ++ E ++ K Sbjct: 1253 ARR--RQEQIQAMPLADSQAVREQL--------RQEQALLEEIERHGE--KVEECQRFAK 1300 Query: 789 E-LERLKD-DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ-------NMNQVYSMSS 839 + + +KD +L +T K + A+ + P ++S V+Q + +++ +++S Sbjct: 1301 QYINAIKDYELQLVTYKAQ--LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1358 Query: 840 TYIDKLKTVNLVLKNTQAAEALVKLYET----KLCEEEAVIADKNNIENLISTLK-QWRS 894 YI K ++ L+ + E L + +L E EA + + + + K Q Sbjct: 1359 QYI---KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415 Query: 895 EVDEKRQVFH--------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKAD------- 939 E E +Q A D Q+ ++I +E+ + + + + +A+ Sbjct: 1416 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1475 Query: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQV-ETTQRKIQENQPENS 998 ++ E + V +Q++ R G L+ R + +Q E +R ++ Q E+ Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1535 Query: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 + ++ + +E E + K Q E ++ E + +A V+ ++ V Sbjct: 1536 RKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQV 1592 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 Q SA+ E R + + + ++ ++ +L EE +R ++ +E Sbjct: 1593 ALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1649 Query: 1119 YSDLLQRQKATVLENSKL-TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 + +R+ LE +L + L E+ +QKS + E K +E AE E R++ + Sbjct: 1650 AREEAERE----LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1705 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 E Q+ AE E ++ R+ E +++ AAE+EL R+R T + E +R +EE L Sbjct: 1706 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1765 Query: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL----IKQ 1293 + + T R+ LE L + + L K + EE R + ++ L+ ++ Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825 Query: 1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 + ++ A + +AE+ +++Q E +A R+ E + E + I +AT + + Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---LAAIGEATRLKTEAEIA 1882 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQD--MRELTYELNALQLEKTSSEEKAR---LLKD 1408 + + + E L++ ++ R+ E+ + E QL K S E R L++D Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942 Query: 1409 KLDETNNT---LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L + + LK E+ + +L + T E+A EA+ +++ Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR------DEKELER 1519 + K + R A + ++ L +++ R +++ + Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062 Query: 1520 LQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579 LQ+ Q + + EK+H +Q + E+E +Q+ L++ AE ++ EE Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQ--QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120 Query: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA---LKIQADGFKDQLRSTNEH----- 1631 E ++ +R A+S V E + ++Q E + QA ++LR E Sbjct: 2121 ----EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176 Query: 1632 -------LHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFK------QKCDQQNIIIQNTK 1678 L ++ + + ++ K E+ L + + E ++ D Q ++ Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--- 2233 Query: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738 +E++ L AE + ++ + E+++ + Q++EL+ +++ E + ++ ++ + Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293 Query: 1739 LFQEESGKFKQSAEEFRKKMEKLMES---KVITENDISGIRLDFVSLQQENSRAQENAKL 1795 QEE+ K KQ AEE + E+ + + E D++ R + +E +A + A Sbjct: 2294 --QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-- 2349 Query: 1796 CETNIKELERQLQQYREQMQ-QGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854 T +K LQQ +E Q Q + ++ + Q Q+L +E +R +E +Q+ + Sbjct: 2350 --TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407 Query: 1855 EHEHQLVLLQCEI---QKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911 E E +L L E+ Q ++ F+ E + E H EL+++ L T Sbjct: 2408 EAE-RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQTLEIQR 2465 Query: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITF- 1970 + + + L E +E+ +++Q + L+ E+ Q E Q + LQ +F Sbjct: 2466 QQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523 Query: 1971 ---DETNPITRLSEIEKIRDQAL--------NNSRPPVRYQDNACEMELVKVLTPLEIAK 2019 D R E EK + + L R + Q E E +++ +E A+ Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583 Query: 2020 NKQYDMHTEVTTLKQEKNPVPS---------AEE---------WMLEGCRASGGLKKGDF 2061 +Q++ V ++E + AEE + E RA+ + Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643 Query: 2062 LKKGLEPETFQNFDG--DHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGL 2119 + +T N D + + E F GLR V+A++L EA +L +++L G Sbjct: 2644 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2703 Query: 2120 KTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAAT 2177 TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQAA+ Sbjct: 2704 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2763 Query: 2178 GFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRM 2235 GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ + Sbjct: 2764 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2823 Query: 2236 LDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNP 2295 + R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F +P Sbjct: 2824 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2883 Query: 2296 NNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK--- 2345 N + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2884 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2943 Query: 2346 -TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFFES 2384 G +T++E R +EK I + ++ ++ + K + FE Sbjct: 2944 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE- 3002 Query: 2385 YGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKK 2442 GL + E +E ID+ L ++ Q G ++ ++A+ R + Sbjct: 3003 -------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3049 Query: 2443 DLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAE 2502 + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V E Sbjct: 3050 --ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDE 3107 Query: 2503 ALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLT 2562 A+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q T Sbjct: 3108 AVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLST 3167 Query: 2563 GGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKAD 2622 GG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 3168 GGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCR 3227 Query: 2623 FDFHTGLKLLEVSE 2636 D TGL LL +SE Sbjct: 3228 PDQLTGLSLLPLSE 3241 Score = 414 bits (1064), Expect = e-115 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 3846 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3897 Query: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 3898 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3946 Query: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 3947 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 4006 Query: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 4007 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4066 Query: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 4067 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4126 Query: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 4127 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4186 Query: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 4187 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4246 Query: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 +Y+ G +++TE AD L +S V + L S P Sbjct: 4247 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4306 Query: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 4307 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4366 Query: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 4367 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4426 Query: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 4427 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4486 Query: 2628 GLKLLEVSEPLMTGISSLY 2646 GL+LLE + G S Y Sbjct: 4487 GLRLLEAAAQSTKGYYSPY 4505 Score = 262 bits (669), Expect = 4e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 3324 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3383 Query: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 3384 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3443 Query: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 3444 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3503 Query: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 3504 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3563 Query: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 L P + V +T ++ + + GS ++++E Q + Sbjct: 3564 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3621 Query: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 LI + +L +Q KE M + GL + Sbjct: 3622 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3680 Query: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 3681 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3736 Query: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 3737 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3796 Query: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 3797 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3856 Query: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 3857 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3906 Score = 219 bits (557), Expect = 4e-56 Identities = 164/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 3001 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3060 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 3061 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3120 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 3121 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3180 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 3181 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3240 Query: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 E+ + SEL E F++ +E + ++ + +E Sbjct: 3241 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3283 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 3284 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3335 Query: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 3336 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3395 Query: 2498 YRVAEALHRGL--------------------------------------VDEGFAQQLRQ 2519 + EA+ RGL V +QL Sbjct: 3396 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3455 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P + +S+ +A+ ++ ++ GIR LE Q TGG+I+P R+ ++ A Sbjct: 3456 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3515 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Q G + L D + P T LTY++ LE+ D TGL+LL Sbjct: 3516 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3568 Score = 207 bits (528), Expect = 8e-53 Identities = 155/556 (27%), Positives = 271/556 (48%), Gaps = 73/556 (13%) Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 3670 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3729 Query: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 3730 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3789 Query: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 3790 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3849 Query: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 3850 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3908 Query: 2327 NIS------NLNVKKTHRISVVDTKTGSE----LTVYEAFQRNLIE--------KSIYLE 2368 ++ + +++ R V+D T + LT E +NL + ++++ Sbjct: 3909 KLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVD 3968 Query: 2369 LSGQQYQWKEAM------------FFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKAL 2416 + ++ +AM E+ + +++ K GL + EA+ G + Sbjct: 3969 ATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIK-GLKLTVEEAVRMGIVG--- 4024 Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 E D LLS V GY SG+ IS+ +A ++ L+ + Sbjct: 4025 -----------PEFKDKLLS-------AERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4066 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 +R LEAQ++TGGIIDP + V A RGL DE + L G P T + + Sbjct: 4067 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4126 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGG---------------LIEPQVHSRLSIEEALQ 2581 + ++ + I + + G+ L + +++P+ +S+ EA + Sbjct: 4127 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4186 Query: 2582 VGIIDVLIATKLKDQK 2597 G+ID +L +Q+ Sbjct: 4187 KGLIDHQTYLELSEQE 4202 Score = 114 bits (284), Expect = 2e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2687 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2744 Query: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2745 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2804 Query: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2805 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2864 Query: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2865 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2924 Query: 2648 SS 2649 S Sbjct: 2925 DS 2926 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 417 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 476 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 477 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514 >gi|58530840 desmoplakin isoform I [Homo sapiens] Length = 2871 Score = 858 bits (2217), Expect = 0.0 Identities = 647/2486 (26%), Positives = 1183/2486 (47%), Gaps = 329/2486 (13%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 +E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K Sbjct: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 + +A +++LE +Y LL S + HL L N + + E++W+N+ EE Sbjct: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY Sbjct: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ + Sbjct: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q Sbjct: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 + ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+ Sbjct: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 +L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+ Sbjct: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726 +SQ S++F D +++ + +++YQ L+ Sbjct: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651 Query: 727 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785 K E + + + E++ IR ++E+CE R+ + ++ H +I E + Sbjct: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711 Query: 786 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845 ++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L Sbjct: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767 Query: 846 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905 TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ + Sbjct: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827 Query: 906 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965 ++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K Sbjct: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887 Query: 966 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025 L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E Sbjct: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947 Query: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085 QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+ Sbjct: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007 Query: 1086 TLMTQYIKFAGDSLKRLE------------EEEIK------------------------- 1108 T Y +F + LK LE EEE++ Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067 Query: 1109 RCKETSEHGAYSDLLQRQ-----KATVLENSKLTGKISELERMVAEL-------KKQKSR 1156 C + A + L+RQ K+ K G+I EL + L K+++ Sbjct: 1068 ECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKS 1127 Query: 1157 VEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELER 1216 VE+ + + + + +Q E++ QK+ +E K+ E+E R + + E R Sbjct: 1128 VEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE---RLRVLLQEEGTR 1184 Query: 1217 VRQLTIEAEAKRAAVEENLLNFRNQLE-ENTFTRRTL-------EDHLKRKDLSLNDLEQ 1268 R+ E R E + N RN+ E E T+ T+ ED K L+ L + Sbjct: 1185 KREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR 1244 Query: 1269 QKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQY 1328 + L +E+ R D+ + + ++ E++ QK + +++KQ +E+E ++ +Q Sbjct: 1245 ENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQ---VMQQ 1301 Query: 1329 TCRENALPVCPITQATSCRAVTGLQQEHDKQKA---EELKQQ---VDELTAANRKAEQDM 1382 +NA + +A + + +E ++ KA EE K++ +EL+ ++++ Sbjct: 1302 RSEDNARHKQSLEEA--AKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEI 1359 Query: 1383 RELTYELNA-LQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLREL 1441 L + + + KT+ + L K ++T+ + +++ + + S++++ L Sbjct: 1360 ISLKNQFETEINITKTTIHQ---LTMQKEEDTSG----YRAQIDNLTRENRSLSEEIKRL 1412 Query: 1442 GRQLNQTT---GKAEEAMQE--ASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAV 1496 L QTT + EE +Q+ A+ + +R QLE+E R+V ++ +V Sbjct: 1413 KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE---------LRQVTQMRTEESV 1463 Query: 1497 AEKNIQHLNSQIHSFRDE-KELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKI 1555 K Q L+ + +D+ KE+ER LK+ +K + K ++ N ++ Sbjct: 1464 RYK--QSLDDAAKTIQDKNKEIER----------LKQLIDKE----TNDRKCLEDENARL 1507 Query: 1556 QRLNEELEKSN----ECAEMLKQKVEELTRQNNETKLMMQ----------RIQAESENIV 1601 QR+ +L+K+N E LK + +ELTR + + + Q R Q + + Sbjct: 1508 QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQ 1567 Query: 1602 LEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVS 1661 L+KQ +++ LK R+ +E K+ K E++ + + L+E K NL Sbjct: 1568 LQKQKVEEELNRLK----------RTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLT- 1616 Query: 1662 EFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQD 1721 Q+ +Q +I+ + ++ ++R L+ EK+R +++++ ++V+ L +L + Q+ Sbjct: 1617 ---QQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673 Query: 1722 ELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVS 1781 + + + + + + K E + E L + ++ E ++ +RL++ Sbjct: 1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDD 1733 Query: 1782 LQQENSRAQENAKLCETNIKELERQLQ--QYREQMQQG-----QHMEANHYQKCQKLEDE 1834 L++ S A + I EL QLQ R QG Q N Q+ +K + + Sbjct: 1734 LRRGRSEADSDK---NATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQ 1790 Query: 1835 LIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGE 1894 + ++ K + Q ++E E LV ++ Q K+ + E + + + E Sbjct: 1791 ALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ------RLEDELNRAKSTLE 1844 Query: 1895 LSSRNTGHLH---PTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKS 1951 +R L ++ L +W K Q+ E+ ++++ E+EKS Sbjct: 1845 AETRVKQRLECEKQQIQNDLNQW---------KTQYSRKEEAIRKIE-------SEREKS 1888 Query: 1952 QQCYSEYFSQTSTELQITFDETNPITRL-SEIEKIRDQALNNSRPPVRYQDNACEMELVK 2010 ++ + S+ I RL +EI++I ++ R + E E + Sbjct: 1889 EREKNSLRSE--------------IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934 Query: 2011 VLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPET 2070 ++ + + Y H E T EW Sbjct: 1935 YQREIDKLRQRPYGSHRETQT----------ECEW------------------------- 1959 Query: 2071 FQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLN 2130 +V + F GLR VTA QL E +L+D T+++L G K+VEEV + Sbjct: 1960 ----------TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ 2009 Query: 2131 KFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYS 2190 FL A SIAG S KEK S A + +I + LEAQAATG IIDP + + Sbjct: 2010 PFLRGAGSIAGA-SASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLT 2068 Query: 2191 VEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQ 2248 V+ A+ + ++D + R ++ AEKA G+ +S KT+SV +A++ ++DR+ G +LEAQ Sbjct: 2069 VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQ 2128 Query: 2249 IASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLR 2308 IASGGV+DPV + +P ++AL +GL++ + + L++P + + F +P K+ + Y +L Sbjct: 2129 IASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 2188 Query: 2309 MCVFDVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLE 2368 C + + L +R++S +++ +TV E ++ S E Sbjct: 2189 RCRIEPHTGLLLLSVQKRSMSFQGIRQ-------------PVTVTELVDSGILRPSTVNE 2235 Query: 2369 LSGQQYQWKEA-----MFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEG 2423 L Q + E F + + + +T T I EA++ G + + E Sbjct: 2236 LESGQISYDEVGERIKDFLQGSSCIAGIYNET-TKQKLGIYEAMKIGLVRPGTALELLEA 2294 Query: 2424 LITLTELADSLLSRLVPKKDLHS-----------------PVAGYWLTASGERISVLKAS 2466 + D + + +P ++ + V GY +G IS+ +A Sbjct: 2295 QAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAM 2354 Query: 2467 RRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITG 2526 + L+++ +R LEAQ++TGGIIDP + V A RG +E ++ L G Sbjct: 2355 NKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKG 2414 Query: 2527 IGHPITNKMMSVVEAVNANIINKEMGIRCLEF-----QYLTGG----------LIEPQVH 2571 P T + ++ ++ I ++E G+ L Q T +++P+ + Sbjct: 2415 FFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETN 2474 Query: 2572 SRLSIEEALQVGIIDVLIATKLKDQK 2597 +S++EA + G+ID +L +Q+ Sbjct: 2475 KEMSVQEAYKKGLIDYETFKELCEQE 2500 Score = 377 bits (969), Expect = e-104 Identities = 218/619 (35%), Positives = 346/619 (55%), Gaps = 50/619 (8%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIA 2140 SV+ FQG+R VT +LV++ +L T+ +L G + +EV + + FL ++ IA Sbjct: 2202 SVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261 Query: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200 G+Y E+TK+K+ A + ++ AL LEAQAATGFI+DP+S VE+A +G+V Sbjct: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321 Query: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258 EF+ +LL AE+A GY+ + +S+FQAM ++++ G +LEAQIA+GG+IDP Sbjct: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381 Query: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318 R+P +IA ++G N + + L +PS +T+ F +PN ++ L Y +L C+ D E+ Sbjct: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441 Query: 2319 FLFPFGERN----ISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY 2374 L P E+ S N + R+ +VD +T E++V EA+++ LI+ + EL Q+ Sbjct: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQEC 2501 Query: 2375 QWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-- 2432 +W+E S G + +L D KTG ++I +AI++G +D+ +Y+ G ++LT+ AD Sbjct: 2502 EWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 2561 Query: 2433 -----------------------------SLLSRLVPKKDL-------------HSPVAG 2450 S +S + ++L SP+A Sbjct: 2562 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621 Query: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510 + T + E+IS+ + R +VD IT R LEAQ TGGII P TG+K + +A+ +G++D Sbjct: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681 Query: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570 + A +L+ + G K MS EAV + E G R LEFQYLTGGL++P+V Sbjct: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741 Query: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630 H R+S EEA++ G ID A +L+D SY + + CP+TK K++YK+A+ ++ + TGL+ Sbjct: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801 Query: 2631 LLEVSEPLMTGISSLYYSS 2649 LLE + G+ S Y S Sbjct: 2802 LLEAASVSSKGLPSPYNMS 2820 Score = 124 bits (311), Expect = 1e-27 Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 12/289 (4%) Query: 2362 EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKK-Y 2420 E LE +YQ +E + SH T T+ + ++ + G K + Y Sbjct: 1923 ETQSQLETERSRYQ-REIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1981 Query: 2421 QEGLITLTELADSLLSRLVPKKDLHSPV------AGYWLTASG---ERISVLKASRRNLV 2471 + LI T L D LL +++ S + AG AS E+ S+++A R+ L+ Sbjct: 1982 ECQLIDKTTL-DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 2040 Query: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531 + + LEAQ +TGGIIDP +K V A+ R L+D QQ+ E ITG P Sbjct: 2041 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 2100 Query: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591 + K +SV EA+ N+I++E G+R LE Q +GG+++P L + AL G+ID + Sbjct: 2101 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 2160 Query: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640 L D + +N + P TK+K++Y + E+ + HTGL LL V + M+ Sbjct: 2161 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMS 2209 >gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens] Length = 1369 Score = 667 bits (1721), Expect = 0.0 Identities = 314/717 (43%), Positives = 503/717 (70%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ Sbjct: 651 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 711 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 771 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RK SCDRS+++ Sbjct: 831 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 891 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+E + R+E Q+Q Sbjct: 951 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190 Query: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250 Query: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310 Query: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367 Score = 64.3 bits (155), Expect = 2e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 523 RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMI 582 Query: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 583 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620 Score = 35.0 bits (79), Expect = 0.98 Identities = 62/264 (23%), Positives = 103/264 (39%), Gaps = 44/264 (16%) Query: 1351 GLQQ--EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408 GL Q E + K E + +L+ A R A +D LQ K + KARL Sbjct: 693 GLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL----DLQYAKLLNSSKARLRS- 747 Query: 1409 KLDETNNTLRCLKLEL---ERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465 L+ ++ + EL K++ E G+ R N T K + S L + Sbjct: 748 -LESLHSFVAAATKELMWLNEKEEEEVGFDWS----DRNTNMTAKK-----ESYSALMR- 796 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525 ELE + +LQ DR+ R A ++ + + + + LQ+C Sbjct: 797 ------ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT----QWSWMLQLCCC 846 Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNEC--------AEMLKQKVE 1577 HLKE ++ Q +++ E ++Q+L E L + N C E L Q + Sbjct: 847 IEAHLKEN--AAYFQFFSDVR---EAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQ 901 Query: 1578 ELTRQNNETKLMMQRIQAESENIV 1601 + Q NE K + + ++ +V Sbjct: 902 DEKEQLNEYKGHLSGLAKRAKAVV 925 Score = 35.0 bits (79), Expect = 0.98 Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 11/115 (9%) Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP-------KVREAAENELR 1173 ++L+ + + E + + ELE A LKK +++ E + P ++R A E R Sbjct: 1236 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295 Query: 1174 KQQRNVE-DISLQKIRAESEAKQYRRELETIVREKEAAERELERV-RQLTIEAEA 1226 QQR+ E D+ +++ R Q + ++ + + +RELE++ RQL E+ Sbjct: 1296 LQQRHGERDVEVERWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES 1348 Score = 33.9 bits (76), Expect = 2.2 Identities = 100/453 (22%), Positives = 170/453 (37%), Gaps = 85/453 (18%) Query: 937 KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY-----RDTYHPLDDWI--------QQV 983 + + L++ Q+ Q++ L G+ K K R HP+ + +QV Sbjct: 892 RLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV 951 Query: 984 ETTQRKIQE------NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK 1037 E T K E QP + K L++ + + S + E Q+ + A + Sbjct: 952 EVTVHKGDECQLVGPAQPSHWKVLSSS-GSEAAVPSVCFLVPPPNQEVQEAVTRLEA--Q 1008 Query: 1038 DYELQTMTYRAMVDSQQKSPVK--RRRMQSSADLIIQEFMDLRT--RYTALVTLMTQYIK 1093 L T+ ++ VD + + RR +Q + F L+ + AL +L Y Sbjct: 1009 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 1068 Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGA----YSDLLQRQKATVLENSKLTGKISELERMVAE 1149 F DS R E+G+ Y LLQ + E S+ ISEL+ + + Sbjct: 1069 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1128 Query: 1150 LKKQKSRVEEEL------PKVREAAEN--ELRKQQRNVEDISLQKIRAESEAKQ------ 1195 L+ ++R L RE A+ E +K Q VE + R +EA++ Sbjct: 1129 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188 Query: 1196 ----------------------------YRRELETI---VREKEAAERELERVRQLTIEA 1224 Y +L+TI +R + AE L + EA Sbjct: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248 Query: 1225 EAKRAAVEE------NLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELR 1278 +A A + E +L R Q E T L D L+ L+Q+ + E+ Sbjct: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308 Query: 1279 RKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKE 1311 R R E + +L+++ + LA Q V +++L++ Sbjct: 1309 RWR---ERVAQLLERWQAVLA-QTDVRQRELEQ 1337 >gi|58530842 desmoplakin isoform II [Homo sapiens] Length = 2272 Score = 606 bits (1562), Expect = e-172 Identities = 368/1259 (29%), Positives = 657/1259 (52%), Gaps = 139/1259 (11%) Query: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 +E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K Sbjct: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240 Query: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 + +A +++LE +Y LL S + HL L N + + E++W+N+ EE Sbjct: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291 Query: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY Sbjct: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ + Sbjct: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q Sbjct: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 + ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+ Sbjct: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 +L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+ Sbjct: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726 +SQ S++F D +++ + +++YQ L+ Sbjct: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651 Query: 727 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785 K E + + + E++ IR ++E+CE R+ + ++ H +I E + Sbjct: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711 Query: 786 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845 ++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L Sbjct: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767 Query: 846 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905 TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ + Sbjct: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827 Query: 906 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965 ++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K Sbjct: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887 Query: 966 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025 L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E Sbjct: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947 Query: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085 QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+ Sbjct: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007 Query: 1086 TLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELER 1145 T Y +F + LK LE+ ++K N+K+ Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLK------------------------NTKI--------- 1034 Query: 1146 MVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVR 1205 +EEEL R+A K + D +LQK +A E Q++ +L ++ Sbjct: 1035 ---------EVLEEELRLARDANSENCNKNK--FLDQNLQKYQA--ECSQFKAKLASLEE 1081 Query: 1206 EKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLND 1265 K AE + + +Q + + + E + ++E+ R+++ED Sbjct: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---------- 1131 Query: 1266 LEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITE 1325 +QQKN ++L++ R E+E +L +QK +EK +KEK+ E+E R + + Sbjct: 1132 FDQQKND-YDQLQKARQCEKE----------NLGWQKLESEKAIKEKE-YEIERLRVLLQ 1179 Query: 1326 IQYTCR---ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382 + T + EN L +A +Q+ K + ++ Q+ + L + EQD Sbjct: 1180 EEGTRKREYENEL----------AKASNRIQE--SKNQCTQVVQERESLLVKIKVLEQDK 1227 Query: 1383 RELTYELNALQLEKTSSEEKARL---LKDKLDETNNTLRCLKLELERKDQAEKGYSQQLR 1439 L + L K++ E + R+ L+ + + N L K + RK++A + + Sbjct: 1228 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287 Query: 1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE--------SLNHEKGKLQREVDRI 1490 + R+ N + E E +K+I+ + +LE L E+ + QRE+D++ Sbjct: 1288 KSEREKNSLRSEIERLQAE---IKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343 Score = 377 bits (969), Expect = e-104 Identities = 218/619 (35%), Positives = 346/619 (55%), Gaps = 50/619 (8%) Query: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIA 2140 SV+ FQG+R VT +LV++ +L T+ +L G + +EV + + FL ++ IA Sbjct: 1603 SVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 1662 Query: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200 G+Y E+TK+K+ A + ++ AL LEAQAATGFI+DP+S VE+A +G+V Sbjct: 1663 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 1722 Query: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258 EF+ +LL AE+A GY+ + +S+FQAM ++++ G +LEAQIA+GG+IDP Sbjct: 1723 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 1782 Query: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318 R+P +IA ++G N + + L +PS +T+ F +PN ++ L Y +L C+ D E+ Sbjct: 1783 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 1842 Query: 2319 FLFPFGERN----ISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY 2374 L P E+ S N + R+ +VD +T E++V EA+++ LI+ + EL Q+ Sbjct: 1843 CLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQEC 1902 Query: 2375 QWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-- 2432 +W+E S G + +L D KTG ++I +AI++G +D+ +Y+ G ++LT+ AD Sbjct: 1903 EWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 1962 Query: 2433 -----------------------------SLLSRLVPKKDL-------------HSPVAG 2450 S +S + ++L SP+A Sbjct: 1963 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2022 Query: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510 + T + E+IS+ + R +VD IT R LEAQ TGGII P TG+K + +A+ +G++D Sbjct: 2023 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2082 Query: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570 + A +L+ + G K MS EAV + E G R LEFQYLTGGL++P+V Sbjct: 2083 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2142 Query: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630 H R+S EEA++ G ID A +L+D SY + + CP+TK K++YK+A+ ++ + TGL+ Sbjct: 2143 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2202 Query: 2631 LLEVSEPLMTGISSLYYSS 2649 LLE + G+ S Y S Sbjct: 2203 LLEAASVSSKGLPSPYNMS 2221 Score = 235 bits (599), Expect = 5e-61 Identities = 306/1402 (21%), Positives = 578/1402 (41%), Gaps = 247/1402 (17%) Query: 1296 KDLAFQKQVAEKQLKEKQK----IELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351 +D+ K + + +KQ+ +EL+ R+ +I++ L P+ S +T Sbjct: 647 QDVNHNKVIETNRENDKQETWMLMELQKIRR--QIEHCEGRMTLKNLPLADQGSSHHITV 704 Query: 1352 LQQE-----HDKQKAEELKQQVDELTAANRKAEQ---------DMRELTYELNALQLEKT 1397 E +D Q E+ Q+ ++ A R +E+ + + +N + Sbjct: 705 KINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL 764 Query: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQA------EKGYSQQLRELGRQLNQTTGK 1451 +S R L + +T + L+ + L ++ + Y L+++ LN Sbjct: 765 NSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSL 824 Query: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQH----LNSQ 1507 E ++I + + + GK +V ++T +K I L Q Sbjct: 825 LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ 884 Query: 1508 IHSFRDEKE-----LERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL 1562 I R+ ++ + L +R+ D L+ +++ + +K + +I ++ Sbjct: 885 IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944 Query: 1563 EKSNECAEMLKQKVEELTRQ------NNETKLMMQ----RIQAESENIVLEKQTIQQR-C 1611 E+ + AE+ +++ Q ET L + IQ+ S I+ E + R Sbjct: 945 EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004 Query: 1612 EALKIQADGFK---DQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCD 1668 E L D ++ + L+S + K TK I+ LEE+L +++ SE C+ Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTK--------IEVLEEELRLARDANSE---NCN 1053 Query: 1669 QQNIIIQNTKK---EVRNLNAELNASKEEKRRGE-------QKVQLQQAQVQELNNRLKK 1718 + + QN +K E A+L + +E KR+ E Q + Q++ELN ++ + Sbjct: 1054 KNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113 Query: 1719 VQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLD 1778 + E IE++ RK V +F Q ++ ++L +++ + ++ +L+ Sbjct: 1114 LTYE-----IEDEKRRRKSV-----EDRFDQQKNDY----DQLQKARQCEKENLGWQKLE 1159 Query: 1779 FVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQ 1838 E IKE E ++++ R +Q+ + ++ E+EL Sbjct: 1160 -----------------SEKAIKEKEYEIERLRVLLQE-------EGTRKREYENELAKA 1195 Query: 1839 KREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSR 1898 ++ K + Q ++E E LV ++ Q K+ + E + + + E +R Sbjct: 1196 SNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR------LEDELNRAKSTLEAETR 1249 Query: 1899 NTGHLHPTPR---SPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCY 1955 L + + L +W K Q+ E+ ++++ E+EKS++ Sbjct: 1250 VKQRLECEKQQIQNDLNQW---------KTQYSRKEEAIRKIES-------EREKSEREK 1293 Query: 1956 SEYFSQTSTELQITFDETNPITRL-SEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTP 2014 + S+ I RL +EI++I ++ R + E E + Sbjct: 1294 NSLRSE--------------IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1339 Query: 2015 LEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNF 2074 ++ + + Y H E T EW Sbjct: 1340 IDKLRQRPYGSHRETQT----------ECEW----------------------------- 1360 Query: 2075 DGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLT 2134 +V + F GLR VTA QL E +L+D T+++L G K+VEEV + FL Sbjct: 1361 ------TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR 1414 Query: 2135 KATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDA 2194 A SIAG S KEK S A + +I + LEAQAATG IIDP + +V+ A Sbjct: 1415 GAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSA 1473 Query: 2195 VLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASG 2252 + + ++D + R ++ AEKA G+ +S KT+SV +A++ ++DR+ G +LEAQIASG Sbjct: 1474 IARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASG 1533 Query: 2253 GVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVF 2312 GV+DPV + +P ++AL +GL++ + + L++P + + F +P K+ + Y +L C Sbjct: 1534 GVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRI 1593 Query: 2313 DVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQ 2372 + + L +R++S +++ +TV E ++ S EL Sbjct: 1594 EPHTGLLLLSVQKRSMSFQGIRQ-------------PVTVTELVDSGILRPSTVNELESG 1640 Query: 2373 QYQWKEA-----MFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITL 2427 Q + E F + + + +T T I EA++ G + + E Sbjct: 1641 QISYDEVGERIKDFLQGSSCIAGIYNET-TKQKLGIYEAMKIGLVRPGTALELLEAQAAT 1699 Query: 2428 TELADSLLSRLVPKKDLHS-----------------PVAGYWLTASGERISVLKASRRNL 2470 + D + + +P ++ + V GY +G IS+ +A + L Sbjct: 1700 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 1759 Query: 2471 VDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHP 2530 +++ +R LEAQ++TGGIIDP + V A RG +E ++ L G P Sbjct: 1760 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 1819 Query: 2531 ITNKMMSVVEAVNANIINKEMGIRCLEF-----QYLTGG----------LIEPQVHSRLS 2575 T + ++ ++ I ++E G+ L Q T +++P+ + +S Sbjct: 1820 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 1879 Query: 2576 IEEALQVGIIDVLIATKLKDQK 2597 ++EA + G+ID +L +Q+ Sbjct: 1880 VQEAYKKGLIDYETFKELCEQE 1901 Score = 124 bits (311), Expect = 1e-27 Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 12/289 (4%) Query: 2362 EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKK-Y 2420 E LE +YQ +E + SH T T+ + ++ + G K + Y Sbjct: 1324 ETQSQLETERSRYQ-REIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1382 Query: 2421 QEGLITLTELADSLLSRLVPKKDLHSPV------AGYWLTASG---ERISVLKASRRNLV 2471 + LI T L D LL +++ S + AG AS E+ S+++A R+ L+ Sbjct: 1383 ECQLIDKTTL-DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 1441 Query: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531 + + LEAQ +TGGIIDP +K V A+ R L+D QQ+ E ITG P Sbjct: 1442 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 1501 Query: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591 + K +SV EA+ N+I++E G+R LE Q +GG+++P L + AL G+ID + Sbjct: 1502 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 1561 Query: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640 L D + +N + P TK+K++Y + E+ + HTGL LL V + M+ Sbjct: 1562 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMS 1610 Score = 60.5 bits (145), Expect = 2e-08 Identities = 124/635 (19%), Positives = 259/635 (40%), Gaps = 112/635 (17%) Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 +DS ES F S+ + +N K + E+ ++ E+ + + L + +++ L+L Sbjct: 909 QDSLESMKFGDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966 Query: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 + L + P++R + +S + QE + +L T + F S+ S Sbjct: 967 SYTSGLETLLNIPIKRTMI-QSPSGVILQEAADVHARYI--ELLTRSGDYYRFLSEMLKS 1023 Query: 815 SSVPTLRS-ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA--AEALVKLYETKLCE 871 L++ ++ V+ + + +S +K K ++ L+ QA ++ KL + + Sbjct: 1024 LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083 Query: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931 +A + K+ +NL Q + ++ ++ + +EDE ++ K++ D F Sbjct: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR-----------F 1132 Query: 932 DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991 D K DQL + Q + + + E K +Y + L +Q+ T +R+ + Sbjct: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYE 1189 Query: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051 + S + NQ +V E E K+ K EQ A ++ E + ++ ++ Sbjct: 1190 NELAKASNRIQESKNQCTQVVQERESLLVKI----KVLEQDKARLQRLEDELNRAKSTLE 1245 Query: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK 1111 ++ + ++R++ I + +T+Y+ +EE I++ + Sbjct: 1246 AETRV---KQRLECEKQQIQNDLNQWKTQYSR-------------------KEEAIRKIE 1283 Query: 1112 ETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENE 1171 +R+K+ +NS SE+ER+ AE+K R+EE + R E+ Sbjct: 1284 S-----------EREKSEREKNSLR----SEIERLQAEIK----RIEE---RCRRKLEDS 1321 Query: 1172 LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAV 1231 R+ Q +E +E +Y+RE++ + + + RE + + T++ Sbjct: 1322 TRETQSQLE----------TERSRYQREIDKLRQRPYGSHRETQTECEWTVD-------- 1363 Query: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQ---KNKLMEELRRKRDNEEELL 1288 T + + D L++K ++ E Q K L + L+ K+ EE Sbjct: 1364 ----------------TSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE--- 1404 Query: 1289 KLIKQMEKDLAFQKQVAEKQLKEKQKIEL-EARRK 1322 + +++ L +A K+K L EA+RK Sbjct: 1405 -VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRK 1438 Score = 37.4 bits (85), Expect = 0.20 Identities = 58/248 (23%), Positives = 111/248 (44%), Gaps = 48/248 (19%) Query: 1502 QHLNSQ--IH-SFRDEK-ELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQR 1557 QH+NS IH S D + +L++++ R+ + Q E+ +E LL KA E D +++ Sbjct: 216 QHINSHRGIHNSIGDYRWQLDKIKADLREKSAIY-QLEEEYENLL---KASFERMDHLRQ 271 Query: 1558 LNEELEKS-------NECAEM------------LKQKVEELTRQNNETKLM---MQRIQA 1595 L ++ + N+C E + QK E + + ++ ++ + +++ Sbjct: 272 LQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQ 331 Query: 1596 ESENIVLEKQTIQQRCEA----LKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEE 1651 ES+ +VL + + EA L+ Q + + HL + Q F+ + + E Sbjct: 332 ESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFE-EAQSTEA 390 Query: 1652 DLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQE 1711 L Q+ + + K CD+ N+ +Q+ ++++ L E E KR QVQ Sbjct: 391 YLKGLQDSIRK-KYPCDK-NMPLQHLLEQIKELEKEREKILEYKR-----------QVQN 437 Query: 1712 LNNRLKKV 1719 L N+ KK+ Sbjct: 438 LVNKSKKI 445 >gi|45439327 periplakin [Homo sapiens] Length = 1756 Score = 372 bits (956), Expect = e-102 Identities = 371/1644 (22%), Positives = 744/1644 (45%), Gaps = 194/1644 (11%) Query: 279 MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 335 +K V +NW V+E +L+ +G+DLP V+ +E H H ++ L AK Sbjct: 129 VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186 Query: 336 EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 395 + + + L+ ++Y KLL S+ +++HL +L +++ R TNEL WL+++ + Sbjct: 187 DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235 Query: 396 EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 + YDWS+RN + +R++ Y + R L+ KEE I + +QLL HP R +IEA+ Sbjct: 236 RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295 Query: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 A+ W L L C E H+K Y +F D K+A + LR + + +KY D Sbjct: 296 EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354 Query: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 +++E L++E ++++ L +Y+ + L + + ++ LK R + PLK IP++A+CD+ Sbjct: 355 YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412 Query: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 + I + L N+ + W+++ GN+ + P+VCF +PP + EA+ LA+ + QY+ Sbjct: 413 EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471 Query: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 +V + K + Y + +KT PG+ S+LQ R Sbjct: 472 SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505 Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 Q+ +G D +++ + QE+++ + Sbjct: 506 ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528 Query: 755 NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 813 +R PLE+ + +S R + + + EL R++ + T + E F Sbjct: 529 ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579 Query: 814 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 873 S + P LR+ + + + + +K+ N + K+ Q + L+ +E L +++ Sbjct: 580 SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639 Query: 874 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 933 V +++ L E+ ++ + +E LQ AK S + ++E D + Sbjct: 640 TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699 Query: 934 HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 993 + + +L +R+ N+ Q++ R + L+ S K + +H D + Q + + Sbjct: 700 QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755 Query: 994 QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1051 + ++ + T+L QK L+ EI ++ ++ + ++QY VKDYEL+ R+++D Sbjct: 756 ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815 Query: 1052 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-EIKR 1109 + KR R+QS A + +E L ++T + + Q ++ +L L ++ E++ Sbjct: 816 NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875 Query: 1110 CKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAE 1169 ET + R + V E K+ ++ E +L+ + +EE+ +R Sbjct: 876 THETLQR-------NRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGP 928 Query: 1170 NE-------LRKQQRNVEDISLQKIRAESEAKQYR-----RELETIVREKEAAEREL--- 1214 E L+K V + S Q+++ +Q++ ELE + + A E+E Sbjct: 929 QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988 Query: 1215 --ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNK 1272 E V + + E RA +E +L R +LE + E + + L ++K++ Sbjct: 989 GQEYVVKEVLRIEPDRAQADE-VLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSR 1047 Query: 1273 LMEELRRKR----DNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQY 1328 E++ K N+ +L +Q+++D Q Q+ EKQ E++ L+ + K E + Sbjct: 1048 AQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQ--EEELSFLQDKLKRLEKER 1105 Query: 1329 TCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYE 1388 E + V + + A +++ +L +Q ++ A R ++++ EL + Sbjct: 1106 AMAEGKITVKEVLKVEKDAAT--------EREVSDLTRQYEDEAAKARASQREKTELLRK 1157 Query: 1389 LNALQLE--KTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN 1446 + AL+ E K +EK R + + + + L+LEL +++ +G +QLR +L Sbjct: 1158 IWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELE 1217 Query: 1447 --QTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL 1504 + G E + ++ K K + ++E E +L+ E+ TR + I L Sbjct: 1218 ALRRRGPQVEVKEVTKEVIKYKTDPEME-----KELQRLREEIVDKTRLIERCDLEIYQL 1272 Query: 1505 NSQIHSFRDEK-ELERLQICQ-----RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRL 1558 +I + +D K +++ ++ Q ++ KE+ +L + K + + + Sbjct: 1273 KKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQ 1332 Query: 1559 NEELEKSNECAEMLKQKV--EELTRQNNETKLMMQRIQAESENIVLEKQTIQQ-RCEALK 1615 E++ + E +K++V +E+ R E L + A +E+I +E + I + R E + Sbjct: 1333 EEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAE-ASAFAESIDVELRQIDKLRAELRR 1391 Query: 1616 IQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQ-QNIII 1674 +Q + +L E L ++ + ++ +R+++ L++ LA + +E ++K Q +++ Sbjct: 1392 LQRR--RTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVL 1449 Query: 1675 QNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTH 1734 Q ++ R +A L EE+ + + QL + +++ L + L +E+ Sbjct: 1450 QQDPQQARE-HALLRLQLEEE---QHRRQLLEGELETLRRK---------LAALEKAEVK 1496 Query: 1735 RKMVL---FQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQE 1791 K+VL Q E G +Q + + +E+ SK + ++S + L+ NS++ + Sbjct: 1497 EKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556 Query: 1792 NAK-LCETNIK-ELERQ-LQQYREQMQQGQHMEANHYQKCQKL---------EDELIAQK 1839 L E N K +LERQ LQ ++Q +M A + + + + L + + Sbjct: 1557 ELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLE 1616 Query: 1840 REVENLK---QKMDQQIKEHEHQL 1860 RE+++LK + D +I E + +L Sbjct: 1617 RELDDLKRLSKDKDLEIDELQKRL 1640 Score = 86.3 bits (212), Expect = 4e-16 Identities = 163/846 (19%), Positives = 350/846 (41%), Gaps = 117/846 (13%) Query: 725 LLKSAEREEQEESVYNLYISEVRNI-RLRLENCEDRLIRQIRTPLERDDLHESVFR---- 779 L A + ++EE+ +EV I R RL+N E L +R E + HE++ R Sbjct: 828 LQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFAL-NLLRQQPEVEVTHETLQRNRPD 886 Query: 780 --ITEQEKLKKELE-------RLKDDLGTITNKCEEFFSQAAASSSV----------PTL 820 + E K++KEL+ +L++++ + + +Q S V P L Sbjct: 887 SGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVL 946 Query: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQ------AAEALVK---LYETKLCE 871 + + + + + ++L+ + L L+ + E +VK E + Sbjct: 947 EESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQ 1006 Query: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA--KAISDEMFKTYKERDL 929 + V+ + +E L +EV +Q AL +E +A K E+ K + L Sbjct: 1007 ADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL 1066 Query: 930 DFDWHK-----EKADQLVERWQNVHVQIDNRLRDLEG----------IGKSLKYYRD--T 972 + ++ + ++ DQL E+ + + ++L+ LE + + LK +D T Sbjct: 1067 EAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT 1126 Query: 973 YHPLDDWIQQVETTQRKIQENQPENSKTL----ATQLNQQKMLVSEIEMK--------QS 1020 + D +Q E K + +Q E ++ L A + K++V E + +S Sbjct: 1127 EREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAES 1186 Query: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT- 1079 ++ + + + E Q +Y++ +++ ++RR Q + +E + +T Sbjct: 1187 EVANLRLELVEQERKYRGAEEQLRSYQSELEA-----LRRRGPQVEVKEVTKEVIKYKTD 1241 Query: 1080 --------RYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQR------ 1125 R + T+ I+ + +L++E I+ K+T +++Q Sbjct: 1242 PEMEKELQRLREEIVDKTRLIERCDLEIYQLKKE-IQALKDTKPQVQTKEVVQEILQFQE 1300 Query: 1126 QKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQ 1185 T E + L K+SE ++ +L+++++ EE++ + E EL + + V + + Sbjct: 1301 DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIAR----KEEELSRVKERV--VQQE 1354 Query: 1186 KIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEEN 1245 +R E E R E + R+++++R + +R +E L +LE Sbjct: 1355 VVRYEEEPG-LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQL----EELERE 1409 Query: 1246 TFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVA 1305 RR E ++R L LEQ++ + E++ + K++ Q + A + + Sbjct: 1410 RQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQ-------KVVLQQDPQQAREHALL 1462 Query: 1306 EKQLKEKQKIELEARRKITEIQY-TCREN--ALPVCPITQATSCRAVTGLQQEHDKQKAE 1362 QL+E+Q RR++ E + T R AL + + +++ +Q+ + Sbjct: 1463 RLQLEEEQH-----RRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQ 1517 Query: 1363 ELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKL 1422 LK ++E + + R+ + ++ L L+ L+ + S ++ L+++ + + L+L Sbjct: 1518 RLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQL 1577 Query: 1423 ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAM-----QEASDLKKIKRNYQLELESLN 1477 E R + + R+L +G ++ +E DLK++ ++ LE++ L Sbjct: 1578 ETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQ 1637 Query: 1478 HEKGKL 1483 G + Sbjct: 1638 KRLGSV 1643 Score = 52.4 bits (124), Expect = 6e-06 Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 8/114 (7%) Query: 2325 ERNISNLNVKKTHR-------ISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWK 2377 ++ + ++ VK+ R I V+ TG EL+ EA + LI+ +++++L Q+ W+ Sbjct: 1637 QKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWE 1696 Query: 2378 EAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELA 2431 E G SS ++ D K+G F+I EA++ G + A +Y +++ ELA Sbjct: 1697 EISVKGPNGESS-VIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELA 1749 >gi|156104874 envoplakin [Homo sapiens] Length = 2033 Score = 300 bits (769), Expect = 1e-80 Identities = 423/2094 (20%), Positives = 846/2094 (40%), Gaps = 297/2094 (14%) Query: 289 VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 348 +++ Q Q+ ++G + +E + H + + I+ + L+ + P T Sbjct: 156 LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206 Query: 349 EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408 + SQY LL + + + L +L+ + T +L L E++ + DWS+ + Sbjct: 207 -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261 Query: 409 AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 467 A +++Y EL +E+++ +++ E+++ HPA I+A++ A++ +W L L Sbjct: 262 AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321 Query: 468 CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 527 C C E ++ Y F +A + L L + KYS +L+Q+ E Sbjct: 322 CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381 Query: 528 KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 587 ++ L + +L +++ + L R + P + + + +ICD+ E+ + + + L Sbjct: 382 EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439 Query: 588 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 647 +N+ W V P G P+ CF +P P+ +AV A+R+ Sbjct: 440 VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481 Query: 648 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 707 AS + ++K L V S L++ + L SQ++ SGSD Sbjct: 482 -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518 Query: 708 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 767 + + Q+LL R + + L E +++ R P Sbjct: 519 LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552 Query: 768 LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826 L R L + RI E + L+ L + T +CE F S + L LN Sbjct: 553 LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612 Query: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886 V + V + S Y +K K + + Q A+ +++ +E L +E + A+ ++ + Sbjct: 613 VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672 Query: 887 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 946 S L++ R E+ E++ L L+ ++ + ++E D + + L +R+ Sbjct: 673 SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732 Query: 947 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006 V Q+D R + ++ + + +++ L W++ + +Q + + + +A +L Sbjct: 733 AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788 Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1065 QK L EI+ ++ ++ A ++DYELQ TYR ++ + S KR R+ Sbjct: 789 AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848 Query: 1066 SADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL 1122 + I + +L YT + + Q ++FA L++ E E R ++ G+ S Sbjct: 849 LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPA 908 Query: 1123 LQRQKATVLENSKLTGKISELERMVAELKKQKS-----RVEEELPKVREAAENELRKQQR 1177 +++ L+ ++L + + R+ EL+ Q+S R + L ++ E E + + Sbjct: 909 QAGRESEALK-AQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQ 967 Query: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 +S K + E E K+ + + +LE Q ++ E+KR ++ +LL Sbjct: 968 LEGSLSRVKAQVEEEGKR-----------RAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016 Query: 1238 FR-------NQLEENTFTRRTLEDHLKRKDLSLN-DLEQQKNKLMEELRRKRD-NEEELL 1288 L+ R L+ +D ++ LE K +L+ +R+ D E+ ++ Sbjct: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076 Query: 1289 KLIKQMEKDLAFQK--QVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSC 1346 K + ++EK+L K Q Q++E +A + ++Q + + + Sbjct: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIV 1136 Query: 1347 RAVTGLQQEHD-KQKAEELKQQVDELTAANRKAEQDMREL--TYELNALQLEKTSSEEKA 1403 + V ++Q+ Q++ L+ ++E N +++ +L Y + Q K +E+ Sbjct: 1137 KEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERV 1196 Query: 1404 RLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK 1463 + ET + LK +L+ G +++ +L L +A++ E ++ Sbjct: 1197 HEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVL--RAQKPTVEYKEVT 1254 Query: 1464 KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEK-ELERLQI 1522 + ++ E L E +L+ +++ + +H +++ + L + +R E+ ++E + Sbjct: 1255 QEVVRHERSPEVL-REIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313 Query: 1523 CQRKSDHLKEQ-FEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQK----VE 1577 + H K+ EK E+L Q ++ + + EL+ E K + V+ Sbjct: 1314 SKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQ 1373 Query: 1578 ELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637 E+ + KL + + L+++ ++R L++Q QLR+ E Sbjct: 1374 EVVVTQKDPKLREEHSRLSGS---LDEEVGRRRQLELEVQ------QLRAGVEEQEGLLS 1424 Query: 1638 TEQDFQRKIKCLEEDLAKSQNLVSEFKQK--CDQQNIIIQNTKKEVRNLNAELNASKEEK 1695 ++D +K+ +E +L + + E +++ Q+ II++ K + + +L S E Sbjct: 1425 FQEDRSKKL-AVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK--DPDLEKSTEAL 1481 Query: 1696 RRGEQKVQLQQAQVQELNNRLKKVQ---DELHLKTIEEQMTHRKMVLFQEESGKFKQSAE 1752 R + ++ QV ELN K +Q D L +E+ +++++ Q++ + E Sbjct: 1482 R---WDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD-----RVLE 1533 Query: 1753 EFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCET---NIKELERQLQQ 1809 + R ++ +++ + R + ++E R +E ET E +LQ+ Sbjct: 1534 DERARVWEMLNRE----------RTARQAREEEARRLRERIDRAETLGRTWSREESELQR 1583 Query: 1810 YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQK 1869 R+Q Q+C +L+ EL R +E KQ+ Q++E E +L+ + E ++ Sbjct: 1584 ARDQAD----------QECGRLQQEL----RALERQKQQQTLQLQE-ESKLLSQKTESER 1628 Query: 1870 KSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRV 1929 + K Q ELS E L EK Q Sbjct: 1629 Q----------------KAAQRGQELS------------------RLEAAILREKDQIYE 1654 Query: 1930 VEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQA 1989 E+ +++ A + +E+ Q + ST++ I ET +S E + Sbjct: 1655 KERTLRDLH-----AKVSREELSQETQTRETNLSTKISILEPETG--KDMSPYEAYKRGI 1707 Query: 1990 LNNSRPPVRYQDNACEMELVKVLTP-------LEIAKNKQYDMHTEVTTLKQEKNP---- 2038 ++ + ++ Q+ C+ E V P L+ KQY + + + K Sbjct: 1708 IDRGQ-YLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLY 1766 Query: 2039 ----VPSAEEWMLEG--CRASGGLKKGDFLKK----GLEPETFQNFDGDHACSVRDDEFK 2088 +P +E +L + S L G + K P++ F + + DD F Sbjct: 1767 KDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFP 1826 Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTK 2148 G+ T T + + ++ + T K L + G+ ++ Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPI------------TGQKLLEAQAATGGIVDLLSR 1874 Query: 2149 EKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208 E+ S A ER +I+ L AQ A I DP++ + SV +AV KG Sbjct: 1875 ERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKG---------- 1924 Query: 2209 LEAEKAAVGYSYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIA 2268 + R+ L+ Q +GG+IDP R R+P + A Sbjct: 1925 --------------------------WMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQA 1958 Query: 2269 LQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFP 2322 L G+++ + Q L + SS + +P +K+ L Y E + C D S L P Sbjct: 1959 LLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012 Score = 192 bits (489), Expect = 3e-48 Identities = 332/1571 (21%), Positives = 650/1571 (41%), Gaps = 242/1571 (15%) Query: 1134 SKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEA 1193 + + K S+++ ++ L +K++ +L + + A+ +R + + + I AE A Sbjct: 611 NSVKNKFSDVQ-VLCSLYGEKAKAALDLERQIQDADRVIRGFEATL--VQEAPIPAEPGA 667 Query: 1194 KQYR-RELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTL 1252 Q R EL+ RE + + R+ + +E AA++ N F L R L Sbjct: 668 LQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRAL 727 Query: 1253 ED--HLKRKDLSLNDLEQQKNKLM-EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQL 1309 D H L L + Q L ++ + +DN L+ + + QV Sbjct: 728 TDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPR--------SQVRPSDG 779 Query: 1310 KEKQKIELEARRKIT-EIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQV 1368 + +L+A++++T EIQ R+ A T + +A+ Q+++ Q A+ + + Sbjct: 780 PSQIAYKLQAQKRLTQEIQSRERDRA------TASHLSQALQAALQDYELQ-ADTYRCSL 832 Query: 1369 DELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKD 1428 + A + + L + A + + + + +L + +LE RK Sbjct: 833 EPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQ--------QLEFARKM 884 Query: 1429 QAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVD 1488 +K S+ +R + +A Q + + R E E+L K +L+ E Sbjct: 885 LEKKELSEDIR-----------RTHDAKQGSESPAQAGR----ESEAL---KAQLEEERK 926 Query: 1489 RITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAE 1548 R+ R + ++ SQ+ R ++ LERL+ + + Q E S L +KA+ Sbjct: 927 RVARV----QHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGS----LSRVKAQ 978 Query: 1549 KENNDKIQR-LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTI 1607 E K + L +LE + + L+ K R+ + L+ + + + L+ Q Sbjct: 979 VEEEGKRRAGLQADLEVAAQKVVQLESK-----RKTMQPHLLTKEVTQVERDPGLDSQAA 1033 Query: 1608 QQRCEALKIQADG--FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665 Q R + +++ + +L + L K E D + K+ ++E + +NL Sbjct: 1034 QLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKV-VVKEVVKVEKNL------ 1086 Query: 1666 KCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725 K + L ++ +++ E+ V QA++++L + V+ ++ + Sbjct: 1087 ----------EMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIV 1136 Query: 1726 KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQE 1785 K +++ +++ G ++S+ ++ L+E ++ Sbjct: 1137 KEVKK---------VEQDPGLLQESS-----RLRSLLE-------------------EER 1163 Query: 1786 NSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENL 1845 A +L + + K + Q+ + Q+Q+ H +Q + E E+ K +++ + Sbjct: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVH---EIFQVDPETEQEITRLKAKLQEM 1220 Query: 1846 KQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHP 1905 K KE E L L+ +K T + +K E+T + +H Sbjct: 1221 AGKRSGVEKEVEKLLPDLEVLRAQKPTVE---YK---EVTQEVVRHE------------- 1261 Query: 1906 TPRSPLLRWTQEPQPLEE--KWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTS 1963 + P+ L E + + ++ E + + Q L+ E+ + +T Sbjct: 1262 ----------RSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETK 1311 Query: 1964 T-ELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQ 2022 T ++ E +P+ E E++R + ++ +D E++ ++L LE K ++ Sbjct: 1312 TVSKEVVRHEKDPVLE-KEAERLRQEVREAAQKRRAAEDAVYELQSKRLL--LERRKPEE 1368 Query: 2023 YDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSV 2082 + EV +++ P E E R SG L + ++ LE E Q G V Sbjct: 1369 KVVVQEVVVTQKD----PKLRE---EHSRLSGSLDEEVGRRRQLELEVQQLRAG-----V 1416 Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGL 2142 + E GL ++ ++ KL R + QL L ++ +E+ T+ + + + Sbjct: 1417 EEQE----GL---LSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVK-- 1467 Query: 2143 YLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDP 2202 LE + A + + + L + + + + S E + K V+ Sbjct: 1468 -LEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526 Query: 2203 EFRIRLLEAEKAAVGYSYSSKTLSVFQAMENRM------------LDRQKGKHILEAQIA 2250 + + R+LE E+A V + ++ + QA E L R + E Q A Sbjct: 1527 Q-KDRVLEDERARV-WEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA 1584 Query: 2251 SGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMC 2310 D G R+ E+ + LQ E ++ + K A EL R+ Sbjct: 1585 RDQA-DQECG-RLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLE 1642 Query: 2311 VFDVESQCFLFPFGERNISNLNVKKTH----------------RISVVDTKTGSELTVYE 2354 + + ++ ER + +L+ K + +IS+++ +TG +++ YE Sbjct: 1643 AAILREKDQIYE-KERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYE 1701 Query: 2355 AFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDK 2414 A++R +I++ YL+L + W+E G S +L D K+G ++I A+ I K Sbjct: 1702 AYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEES-VLLDRKSGKQYSIEAALRCRRISK 1760 Query: 2415 ALVKKYQEGLITLTELA----------DSL-LSRLVPKKDLHS----------------- 2446 Y++G + ++E A SL + ++ K L S Sbjct: 1761 EEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGL 1820 Query: 2447 -----PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVA 2501 P+AG + T + + S+ A +N++D IT + LEAQ +TGGI+D L+ ++Y V Sbjct: 1821 GDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVH 1880 Query: 2502 EALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYL 2561 +A+ RGL++ Q+L + TGI P+T K +SV EAV + +E + L+ Q+L Sbjct: 1881 KAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHL 1940 Query: 2562 TGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKA 2621 TGGLI+P+ R+ I++AL G+I +A L+D+ SY +++ P +K +L+YKEA+ + Sbjct: 1941 TGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRC 2000 Query: 2622 DFDFHTGLKLL 2632 D +GL LL Sbjct: 2001 RKDPLSGLLLL 2011 Score = 113 bits (283), Expect = 2e-24 Identities = 266/1397 (19%), Positives = 554/1397 (39%), Gaps = 186/1397 (13%) Query: 990 IQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1049 +QE E + L QQ ++ ++ C + +D Q RA+ Sbjct: 668 LQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRAL 727 Query: 1050 VDSQQKSPVK---RRRMQSSADLIIQEFMDLRTRYTALVTLMTQ----------YIKFAG 1096 D + R ++ A L Q+F + + ++ + + + I + Sbjct: 728 TDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKL 787 Query: 1097 DSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI--SELERMVAELKKQK 1154 + KRL +E R ++ + S LQ L++ +L LE +A ++ Sbjct: 788 QAQKRLTQEIQSRERDRATASHLSQALQ----AALQDYELQADTYRCSLEPTLAVSAPKR 843 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQY--RRELETIVREKEAAER 1212 RV L + +A E L K V Q ++ A++ ++EL +R A++ Sbjct: 844 PRVAP-LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQ 902 Query: 1213 ELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNK 1272 E Q E+EA +A +EE KR ++LE Q+++ Sbjct: 903 GSESPAQAGRESEALKAQLEEER---------------------KRVARVQHELEAQRSQ 941 Query: 1273 LMEELRRKRD----NEEELLKLIK--QMEKDLAFQKQVAEKQLKEKQKIELE---ARRKI 1323 L++ LR +R E+E+++ + Q+E L+ K E++ K + ++ + A +K+ Sbjct: 942 LLQ-LRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKV 1000 Query: 1324 TEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMR 1383 +++ + R+ P + T GL + A +L+ Q+ +L + + Sbjct: 1001 VQLE-SKRKTMQPHLLTKEVTQVERDPGLDSQ-----AAQLRIQIQQLRGEDAVISARLE 1054 Query: 1384 ELTYELNALQLEKTSSEEKARLLK----DKLDETNNTLRCLKLELE----RKDQAEKGYS 1435 L EL AL+ + +EK + + +K E + L+L++E R+ QAE+ + Sbjct: 1055 GLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVA 1114 Query: 1436 Q---QLRELGRQLNQTTGKA--EEAMQEASDLKKIKRNYQLE--LESLNHEKGKLQREVD 1488 + ++ +L R ++ K +E + D ++ + +L LE + L RE+ Sbjct: 1115 KLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELS 1174 Query: 1489 RITRAHAVAEKNIQ--HLNSQIHSF-----RDEKELERLQICQRKSDHLKEQFEKSHEQL 1541 + ++V EK L ++H E+E+ RL+ ++ + EK E+L Sbjct: 1175 DLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234 Query: 1542 LQNIKAEKENNDKIQ--RLNEELEKSNECAEMLKQ------KVEELTRQNNETKLMMQRI 1593 L +++ + ++ + +E+ + E+L++ ++ EL + ++ + R+ Sbjct: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294 Query: 1594 QAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDL 1653 Q E + E+ ++ + + ++ L E L ++ + +R + +L Sbjct: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYEL 1354 Query: 1654 AKSQNLVSEFK--QKCDQQNIIIQNTKKEVRNLNAELNASKEE----KRRGEQKVQLQQA 1707 + L+ K +K Q +++ ++R ++ L+ S +E +R+ E +VQ +A Sbjct: 1355 QSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRA 1414 Query: 1708 QVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL--MESK 1765 V+E L +D +E ++ R++ L +E K + +E + ME++ +E Sbjct: 1415 GVEEQEGLLSFQEDRSKKLAVEREL--RQLTLRIQELEKRPPTVQE-KIIMEEVVKLEKD 1471 Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825 E +R D L QE ++ E + C+ +++ + Q + ++ + E Sbjct: 1472 PDLEKSTEALRWD---LDQEKTQVTELNRECKN--LQVQIDVLQKAKSQEKTIYKEVIRV 1526 Query: 1826 QKCQKLEDE------LIAQKREVENLKQKMDQQIKEHEHQLVLL-------QCEIQKKST 1872 QK + LEDE ++ ++R +++ ++++E + L + E+Q+ Sbjct: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARD 1586 Query: 1873 AKD--C--------TFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLE 1922 D C + + + Q +L S+ T + R + QE LE Sbjct: 1587 QADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKT----ESERQKAAQRGQELSRLE 1642 Query: 1923 EKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEI 1982 + KE + A + +E+ Q + ST++ I ET +S Sbjct: 1643 AAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGK--DMSPY 1700 Query: 1983 EKIRDQALNNSRPPVRYQDNACEMELVKVLTP-------LEIAKNKQYDMHTEVTTLKQE 2035 E + ++ + ++ Q+ C+ E V P L+ KQY + + + Sbjct: 1701 EAYKRGIIDRGQY-LQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRIS 1759 Query: 2036 KNP--------VPSAEEWMLEG--CRASGGLKKGDFLKKGL----EPETFQNFDGDHACS 2081 K +P +E +L + S L G + K P++ F + Sbjct: 1760 KEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLG 1819 Query: 2082 VRDDEFKFQGLRHT-------------------VTARQLVEAKLLDMRTIEQLRLGLKTV 2122 + DD F G+ T +T ++L+EA+ ++ L +V Sbjct: 1820 LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSV 1879 Query: 2123 EEVQK-------TLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQA 2175 + + + + L + G+ TK+++S A ++ + + L L+ Q Sbjct: 1880 HKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQH 1939 Query: 2176 ATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKA---AVGYSYSSKTLSVFQAME 2232 TG +IDP ++ A+L G++ E +LL+ E + + S + LS +AM Sbjct: 1940 LTGGLIDPKRTGRIPIQQALLSGMISEEL-AQLLQDESSYEKDLTDPISKERLSYKEAMG 1998 Query: 2233 NRMLDRQKGKHILEAQI 2249 D G +L A + Sbjct: 1999 RCRKDPLSGLLLLPAAL 2015 Score = 32.7 bits (73), Expect = 4.9 Identities = 23/101 (22%), Positives = 46/101 (45%) Query: 60 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119 L + +R+Q ++ E ++ LQ D E Q++ E + E E LL+ Sbjct: 39 LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98 Query: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160 +DV K+ QA+++ + + +L + + E ++Y K Sbjct: 99 LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139 >gi|207452735 epiplakin 1 [Homo sapiens] Length = 5090 Score = 261 bits (667), Expect = 6e-69 Identities = 208/698 (29%), Positives = 339/698 (48%), Gaps = 70/698 (10%) Query: 1992 NSRPPVRYQDN----ACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWML 2047 ++R V YQ C+ E +L PL + D HT V L+ K PV + Sbjct: 1407 SARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDHTAVA-LRAMKVPVSTGR---F 1462 Query: 2048 EGCRAS-GGLKKGDFLKKGLEPETFQNFDGDHACSVRDD----------------EFKFQ 2090 +GC S L +++ E A ++R + F+ Sbjct: 1463 KGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQVVSAVTALVEAAERQPLQATFR 1522 Query: 2091 GLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLESTK 2148 GLR V+AR L A+L+ +T+++L G TV+EV + ++ + L IAG+ ++ T+ Sbjct: 1523 GLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVLIQGTQ 1582 Query: 2149 EKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208 E++S A R I+ AL LEAQAATGFIIDP + +VE+A G+ E ++L Sbjct: 1583 ERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKL 1642 Query: 2209 LEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPE 2266 L AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GG+IDPV RVP + Sbjct: 1643 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVPVD 1702 Query: 2267 IALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGER 2326 +A + G + + + L +PS +T+ F +PN + L Y +LL CV D E+ +L ++ Sbjct: 1703 VAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQIIKK 1762 Query: 2327 NISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY--QWKEAMFFES 2384 + + + + R V+ ++T F ++ + +L Y + ++ + Sbjct: 1763 GENYVYINEATR-HVLQSRTAKMRV--GRFADQVVS---FWDLLSSPYFTEDRKRELIQE 1816 Query: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGT-IDKALVKKYQEGLITLTELADSLLSRLVPKKD 2443 YG S L + I E Q I A ++ G +T AD SR++ +K Sbjct: 1817 YGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIR----GEVT---AADLFNSRVIDQKT 1869 Query: 2444 LHS-------------------------PVAGYWLTASGERISVLKASRRNLVDRITALR 2478 LH+ +AG + ++ E +S+ +ASR+ L+ A Sbjct: 1870 LHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATW 1929 Query: 2479 CLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSV 2538 LEAQ +TG ++DP T +K V EA+ GLV+E ++L + E TG P T + + Sbjct: 1930 LLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTIPL 1989 Query: 2539 VEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKS 2598 +A+ +I K +R LE Q TGG+I+PQ H RL +E A + G + I + DQK Sbjct: 1990 FQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKH 2049 Query: 2599 YVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + + P T+ K++Y+E E+ TG L V++ Sbjct: 2050 MRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNK 2087 Score = 255 bits (651), Expect = 5e-67 Identities = 187/570 (32%), Positives = 303/570 (53%), Gaps = 34/570 (5%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 F GLR TVT +L++A+++D E+L G T ++V + ++L IAGL L Sbjct: 560 FSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPG 619 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 ++E++S A + ++ AL LEAQAATGFIIDP + + +SVE+A+ V+ P+ Sbjct: 620 SQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFA 679 Query: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GGVIDPV RVP Sbjct: 680 KLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 739 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 ++A ++G + + L +PS +T+ F +PN + L Y +LL CV D E+ +L P Sbjct: 740 VDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLS 799 Query: 2325 ERN--ISNLNVKKTHRISVVDTKTGS---------ELTVYEAF----QRNLIEKSIYLEL 2369 + + ++ + ++ K G EL E F +R L+ + E+ Sbjct: 800 STQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREV 859 Query: 2370 S-GQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLT 2428 + GQ + EA E+ + ML ++ + +++ +E G ID+ L+ + G I+ Sbjct: 860 TLGQVAKLLEA---ETQRQADIMLPALRSRV--TVHQLLEAGIIDQQLLDQVLAGTIS-- 912 Query: 2429 ELADSLLSRLVPKKDLHS--PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVST 2486 ++LL ++ L V G L SG+R+S+ +A R+ L+ AL LEAQ +T Sbjct: 913 --PEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAAT 970 Query: 2487 GGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANI 2546 G I+DP + + V EA+ RG+V +L++ E I G P + K +SV +A+ + Sbjct: 971 GTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGL 1030 Query: 2547 INKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICP 2606 I E R LE Q TGG+I+P H L + A+Q G +D + T L S P Sbjct: 1031 IPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETAL---SSSSETFPTP 1087 Query: 2607 QTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 + + +Y + LE+ D +GL LL + E Sbjct: 1088 DGQGRTSYAQLLEECPRDETSGLHLLPLPE 1117 Score = 224 bits (571), Expect = 9e-58 Identities = 167/564 (29%), Positives = 277/564 (49%), Gaps = 22/564 (3%) Query: 2091 GLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEV--QKTLNKFLTKATSIAGLYLESTK 2148 G R V A L++A ++ T+E L G ++ +V Q + L +AG+ L+ + Sbjct: 1198 GPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSG 1257 Query: 2149 EKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208 K S A A ++ + LEAQ A+GF++DP++ Q SVEDAV G+V E +L Sbjct: 1258 AKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQL 1317 Query: 2209 LEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPE 2266 +AE+AA GY YS +LS++QAME ++ + +G +L+ Q+A+GGV+DPV G+ +P Sbjct: 1318 GQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQA 1377 Query: 2267 IALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGER 2326 A + GLL+ Q L + + F +P+ + + Y +L CV D E+ L P Sbjct: 1378 AACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSD 1437 Query: 2327 NISNL--NVKKTHRISVVDTKTGS---------ELTVYEAFQRNLIEKSIYLELSGQQYQ 2375 + + + R V TG +L + E + + + L SG+ Sbjct: 1438 TVLEVDDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAA 1497 Query: 2376 WKE---AMFFESYGHSSHMLTDTKTGLHFNIN--EAIEQGTIDKALVKKYQEGLITLTEL 2430 ++ A+ L T GL ++ + I + + + +G T+ E+ Sbjct: 1498 LRQVVSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEV 1557 Query: 2431 ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGII 2490 A+ + + + + +AG + + ER+S+ +A RR+++ TAL LEAQ +TG II Sbjct: 1558 AE--MDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFII 1615 Query: 2491 DPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKE 2550 DP +K V EA G+ + +L E +TG P T + +S+ +A+ ++I +E Sbjct: 1616 DPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVRE 1675 Query: 2551 MGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKR 2610 GIR LE Q TGG+I+P R+ ++ A + G D + L D + P T Sbjct: 1676 HGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHE 1735 Query: 2611 KLTYKEALEKADFDFHTGLKLLEV 2634 LTY + LE+ D TGL LL++ Sbjct: 1736 NLTYLQLLERCVEDPETGLYLLQI 1759 Score = 223 bits (567), Expect = 3e-57 Identities = 172/596 (28%), Positives = 281/596 (47%), Gaps = 71/596 (11%) Query: 2088 KFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLN---KFLTKATSIAGLYL 2144 K +R VTA L ++++D +T+ LR+G +T + TL +L + IAG+ + Sbjct: 1846 KVAAIRGEVTAADLFNSRVIDQKTLHTLRVG-RTGGQALSTLECVKPYLEGSDCIAGVTV 1904 Query: 2145 ESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEF 2204 ST+E +S A+ + +I A LEAQAATGF++DP + Q SV++AV G+V+ E Sbjct: 1905 PSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEEL 1964 Query: 2205 RIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIR 2262 R RLL+AE+AA GY + T+ +FQAM+ +++++ + +LE Q+A+GGVIDP R Sbjct: 1965 RERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHR 2024 Query: 2263 VPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFP 2322 +P E A ++G L+ I + + + F +PN ++ + Y EL C ++ LFP Sbjct: 2025 LPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFP 2084 Query: 2323 FGERNISNLNV---------------------------------------KKTHRISVVD 2343 + + ++ KK + + Sbjct: 2085 VNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYR 2144 Query: 2344 TKTGSELTVYEAFQRNLIEK----SIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGL 2399 T T L LIEK + +L G + Q + S + ML D +TG Sbjct: 2145 THTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETG- 2203 Query: 2400 HFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGER 2459 + Q ++ VK+Y EG + LVP KD E+ Sbjct: 2204 -----RSTTQELMEDDRVKRYLEG-------TSCIAGVLVPAKD---------QPGRQEK 2242 Query: 2460 ISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQ 2519 +S+ +A + ++ TAL LEAQ +TG +IDP+ + V E + G+V ++L Sbjct: 2243 MSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLS 2302 Query: 2520 CELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEA 2579 E +TG P T + +S+ +A+ ++I +E GIR LE Q TGG+I+P R+ ++ A Sbjct: 2303 AERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVA 2362 Query: 2580 LQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635 + G D + L D + P T LTY + L + D TGL +L+++ Sbjct: 2363 YRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 2418 Score = 216 bits (549), Expect = 3e-55 Identities = 177/575 (30%), Positives = 276/575 (48%), Gaps = 38/575 (6%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEV--QKTLNKFLTKATSIAGLYLES 2146 F+ + V+A +L+E +LD + ++ LR G +V + + ++L S+AG+ L Sbjct: 235 FRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLP 294 Query: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 K SF AA ++ AL LEAQAAT ++DPI+GQ V++AV G+V PE Sbjct: 295 EGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHE 354 Query: 2207 RLLEAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 +LL AE+A G+ +S + +FQAM+ ++DR +L+AQ+A+GG++ P R +R+P Sbjct: 355 QLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLP 414 Query: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPF- 2323 E AL+ G L+ + L + S + L Y +LL +CV D E+ P Sbjct: 415 LEAALRCGCLDEDTQRQLSQAGSF-----SDGTHGGLRYEQLLALCVTDPETGLAFLPLS 469 Query: 2324 -----GERNISNLNVKKTHRISVVDTKT-------GSELTVYEAFQRNLIEKSIYLELSG 2371 GE T + T T G ++++E I S + Sbjct: 470 GGPRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAI-SSEQRAMLA 528 Query: 2372 QQYQWKEAMFFESYGHSSHMLTD-------TKTGLHFNI--NEAIEQGTIDKALVKKYQE 2422 QQYQ + S L T +GL + E ++ ID+ L ++ + Sbjct: 529 QQYQEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEH 588 Query: 2423 GLITLTELADSLLSRLVPKKDLHSP--VAGYWLTASGERISVLKASRRNLVDRITALRCL 2480 G T ++ SL S ++ L +AG L S ER+S+ +A + L+ TAL L Sbjct: 589 GQATAKDVG-SLAS---AQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILL 644 Query: 2481 EAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVE 2540 EAQ +TG IIDP K + V EAL ++ +L E +TG P T + +S+ + Sbjct: 645 EAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQ 704 Query: 2541 AVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYV 2600 A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D ++ L D Sbjct: 705 AMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDT 764 Query: 2601 RNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635 + P T LTY + LE+ D TGL LL +S Sbjct: 765 KGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLS 799 Score = 174 bits (440), Expect = 1e-42 Identities = 154/609 (25%), Positives = 268/609 (44%), Gaps = 109/609 (17%) Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEV--QKTLNKFLTKATSIA 2140 R + LR VT QL+EA ++D + ++Q+ G + E + + ++L ++ Sbjct: 874 RQADIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVG 933 Query: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200 G+ L + +++S A + ++ VALA LEAQAATG I+DP S ++ SV++AV +GVV Sbjct: 934 GVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVV 993 Query: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258 PE RL AE A G+ +S K +SVFQAM+ ++ ++ +LEAQ+A+GG+IDP Sbjct: 994 GPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPT 1053 Query: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318 +P +A+Q+G ++ + L SS++ FP P+ + Y++LL C D S Sbjct: 1054 SHHHLPMPVAIQRGYVDQEMETAL---SSSSETFPTPDGQGRTSYAQLLEECPRDETSGL 1110 Query: 2319 FLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKE 2378 L P E + L E QR+L + Sbjct: 1111 HLLPLPE--------------------SAPALPTEEQVQRSL-----------------Q 1133 Query: 2379 AMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLL--- 2435 A+ G S L D + HF + + L++ QEG T+ +L S+ Sbjct: 1134 AVPGAKDGTS---LWDLLSSCHFTEEQR-------RGLLEDVQEGRTTVPQLLASVQRWV 1183 Query: 2436 --SRLVPKKDLHSP-----VAGYWLTASG-------ERISVLKASRRNLVDRITALRCLE 2481 ++L+ + + P V WL +G E ++ S + ++ CL Sbjct: 1184 QETKLLAQARVMVPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLW 1243 Query: 2482 AQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEA 2541 G++ +G K +A+A+ GL+ G Q+L + ++ + P+ N+ +SV +A Sbjct: 1244 GTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDA 1303 Query: 2542 VNANIINKEM--------------------------------------GIRCLEFQYLTG 2563 V ++ +E+ G+ L+ Q TG Sbjct: 1304 VKVGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATG 1363 Query: 2564 GLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADF 2623 G+++P L A ++G++D + L + P + ++TY++ E+ Sbjct: 1364 GVVDPVHGVHLPQAAACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVC 1423 Query: 2624 DFHTGLKLL 2632 D TGL LL Sbjct: 1424 DSETGLLLL 1432 Score = 166 bits (419), Expect = 4e-40 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%) Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140 R + F+GLR V+A +L + +L T+ L G KT++EV + ++ ++L + IA Sbjct: 2702 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 2761 Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195 G+ + + +EK+S A + ++ AL LEAQAATGF+IDP+ SVE+AV Sbjct: 2762 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 2821 Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253 GVV E + +LL AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GG Sbjct: 2822 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 2881 Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313 VIDPV RVP ++A ++G + + + L +PS +T+ F +PN + L Y +LLR CV D Sbjct: 2882 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 2941 Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373 ++ ++ R + + + R ++ D + + ++ E Y E+S + Sbjct: 2942 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 3001 Query: 2374 YQ 2375 Q Sbjct: 3002 RQ 3003 Score = 166 bits (419), Expect = 4e-40 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%) Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140 R + F+GLR V+A +L + +L T+ L G KT++EV + ++ ++L + IA Sbjct: 3236 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 3295 Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195 G+ + + +EK+S A + ++ AL LEAQAATGF+IDP+ SVE+AV Sbjct: 3296 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 3355 Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253 GVV E + +LL AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GG Sbjct: 3356 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 3415 Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313 VIDPV RVP ++A ++G + + + L +PS +T+ F +PN + L Y +LLR CV D Sbjct: 3416 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 3475 Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373 ++ ++ R + + + R ++ D + + ++ E Y E+S + Sbjct: 3476 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 3535 Query: 2374 YQ 2375 Q Sbjct: 3536 RQ 3537 Score = 166 bits (419), Expect = 4e-40 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%) Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140 R + F+GLR V+A +L + +L T+ L G KT++EV + ++ ++L + IA Sbjct: 3770 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 3829 Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195 G+ + + +EK+S A + ++ AL LEAQAATGF+IDP+ SVE+AV Sbjct: 3830 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 3889 Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253 GVV E + +LL AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GG Sbjct: 3890 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 3949 Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313 VIDPV RVP ++A ++G + + + L +PS +T+ F +PN + L Y +LLR CV D Sbjct: 3950 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 4009 Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373 ++ ++ R + + + R ++ D + + ++ E Y E+S + Sbjct: 4010 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 4069 Query: 2374 YQ 2375 Q Sbjct: 4070 RQ 4071 Score = 166 bits (419), Expect = 4e-40 Identities = 103/302 (34%), Positives = 171/302 (56%), Gaps = 9/302 (2%) Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140 R + F+GLR V+A +L + +L T+ L G KT++EV + ++ ++L + IA Sbjct: 4304 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 4363 Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195 G+ + + +EK+S A + ++ AL LEAQAATGF+IDP+ SVE+AV Sbjct: 4364 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 4423 Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253 GVV E + +LL AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GG Sbjct: 4424 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 4483 Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313 VIDPV RVP ++A ++G + + + L +PS +T+ F +PN + L Y +LLR CV D Sbjct: 4484 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPD 4543 Query: 2314 VESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQ 2373 ++ ++ R + + + R ++ D + + ++ E Y E+S + Sbjct: 4544 PDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDR 4603 Query: 2374 YQ 2375 Q Sbjct: 4604 RQ 4605 Score = 161 bits (408), Expect = 7e-39 Identities = 97/296 (32%), Positives = 166/296 (56%), Gaps = 9/296 (3%) Query: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKT--LNKFLTKATSIAGLYLES 2146 FQG+R +TA +L+ + ++ ++ L G T +E+ + + ++L + IAG+ + + Sbjct: 2174 FQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPA 2233 Query: 2147 T-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVD 2201 +EK+S A + ++ AL LEAQAATGF+IDP+ SVE+ V GVV Sbjct: 2234 KDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVG 2293 Query: 2202 PEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVR 2259 E + +LL AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GGVIDPV Sbjct: 2294 SEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVH 2353 Query: 2260 GIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCF 2319 RVP ++A ++G + + + L +PS +T+ F +PN + L Y +LLR CV D ++ + Sbjct: 2354 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLY 2413 Query: 2320 LFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQ 2375 + R + + + R ++ D + + ++ E Y E+S + Q Sbjct: 2414 MLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQ 2469 Score = 158 bits (400), Expect = 6e-38 Identities = 93/243 (38%), Positives = 148/243 (60%), Gaps = 9/243 (3%) Query: 2083 RDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIA 2140 R + F+GLR V+A +L + +L T+ L G KT++EV + ++ ++L + IA Sbjct: 4838 RLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIA 4897 Query: 2141 GLYLEST-----KEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAV 2195 G+ + + +EK+S A + ++ AL LEAQAATGF+IDP+ SVE+AV Sbjct: 4898 GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAV 4957 Query: 2196 LKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGG 2253 GVV E + +LL AE+A GY+ Y+ + +S+FQAM+ ++ R+ G +LEAQIA+GG Sbjct: 4958 AAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG 5017 Query: 2254 VIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFD 2313 VIDPV RVP ++A ++G + + + L +PS +T+ F +PN + L Y +LL+ D Sbjct: 5018 VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLD 5077 Query: 2314 VES 2316 E+ Sbjct: 5078 PET 5080 Score = 155 bits (391), Expect = 7e-37 Identities = 124/417 (29%), Positives = 195/417 (46%), Gaps = 53/417 (12%) Query: 2135 KATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDA 2194 +A SIAG+Y+E++ + S +A E+ ++ + A LEAQAATG ++D GQ V A Sbjct: 39 QARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKA 98 Query: 2195 VLKGVVDPEFRIRLLEAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASG 2252 + +G+V E + +LL AE+A GY Y + L++FQA+ ++DR G+ LE Q+A+G Sbjct: 99 LQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATG 158 Query: 2253 GVIDPVRGIRVPPEIALQQGLLNNAILQFLH--EPSSNTRVFPNPNNKQALYYSELLRMC 2310 G++DP +G+ V PE A QGLL+ L EP + F NPN + L Y +LL C Sbjct: 159 GLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERC 218 Query: 2311 VFDVESQCFLFPF-------------------GERNISNLNVKKTHRISVVDTKTGSELT 2351 V S L P G + + + R++ VD +E+ Sbjct: 219 VRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVR 278 Query: 2352 VYEAFQRNLI---------EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFN 2402 Y ++ +KS + + A+ ++H L D TG Sbjct: 279 RYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLW 338 Query: 2403 INEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISV 2462 ++EA+ G + EL + LL V G+ SG +I + Sbjct: 339 VDEAVRAGLVS--------------PELHEQLLV-------AEQAVTGHHDPFSGSQIPL 377 Query: 2463 LKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQ 2519 +A ++ LVDR ALR L+AQ++TGG++ P + + AL G +DE +QL Q Sbjct: 378 FQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQ 434 Score = 104 bits (259), Expect = 1e-21 Identities = 70/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%) Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 VK+Y EG + + LVP KD E++S+ +A + ++ TA Sbjct: 4886 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 4929 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 L LEAQ +TG +IDP+ + V EA+ G+V ++L E +TG P T + + Sbjct: 4930 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 4989 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596 S+ +A+ ++I +E GIR LE Q TGG+I+P R+ ++ A + G D + L D Sbjct: 4990 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 5049 Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635 + P T LTY + L++A D TGL L +S Sbjct: 5050 SDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLS 5088 Score = 99.8 bits (247), Expect = 3e-20 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%) Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 VK+Y EG + + LVP KD E++S+ +A + ++ TA Sbjct: 2750 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 2793 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 L LEAQ +TG +IDP+ + V EA+ G+V ++L E +TG P T + + Sbjct: 2794 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 2853 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596 S+ +A+ ++I +E GIR LE Q TGG+I+P R+ ++ A + G D + L D Sbjct: 2854 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 2913 Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635 + P T LTY + L + D TGL +L+++ Sbjct: 2914 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 2952 Score = 99.8 bits (247), Expect = 3e-20 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%) Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 VK+Y EG + + LVP KD E++S+ +A + ++ TA Sbjct: 3284 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 3327 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 L LEAQ +TG +IDP+ + V EA+ G+V ++L E +TG P T + + Sbjct: 3328 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 3387 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596 S+ +A+ ++I +E GIR LE Q TGG+I+P R+ ++ A + G D + L D Sbjct: 3388 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 3447 Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635 + P T LTY + L + D TGL +L+++ Sbjct: 3448 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 3486 Score = 99.8 bits (247), Expect = 3e-20 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%) Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 VK+Y EG + + LVP KD E++S+ +A + ++ TA Sbjct: 3818 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 3861 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 L LEAQ +TG +IDP+ + V EA+ G+V ++L E +TG P T + + Sbjct: 3862 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 3921 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596 S+ +A+ ++I +E GIR LE Q TGG+I+P R+ ++ A + G D + L D Sbjct: 3922 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 3981 Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635 + P T LTY + L + D TGL +L+++ Sbjct: 3982 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 4020 Score = 99.8 bits (247), Expect = 3e-20 Identities = 68/219 (31%), Positives = 109/219 (49%), Gaps = 16/219 (7%) Query: 2417 VKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITA 2476 VK+Y EG + + LVP KD E++S+ +A + ++ TA Sbjct: 4352 VKRYLEGTSCIAGV-------LVPAKDQ---------PGRQEKMSIYQAMWKGVLRPGTA 4395 Query: 2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMM 2536 L LEAQ +TG +IDP+ + V EA+ G+V ++L E +TG P T + + Sbjct: 4396 LVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQI 4455 Query: 2537 SVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQ 2596 S+ +A+ ++I +E GIR LE Q TGG+I+P R+ ++ A + G D + L D Sbjct: 4456 SLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADP 4515 Query: 2597 KSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVS 2635 + P T LTY + L + D TGL +L+++ Sbjct: 4516 SDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLA 4554 Score = 87.0 bits (214), Expect = 2e-16 Identities = 57/195 (29%), Positives = 99/195 (50%), Gaps = 2/195 (1%) Query: 2440 PKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYR 2499 P + +AG ++ ASG+ SV A + L+ LEAQ +TGG++D G+ Sbjct: 35 PPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLP 94 Query: 2500 VAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQ 2559 V++AL +GLV ++L E TG P + +++ +A+ ++++ +G LE Q Sbjct: 95 VSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQ 154 Query: 2560 YLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNI--ICPQTKRKLTYKEA 2617 TGGL++P ++ E A G++D KL + + ++ + P T +LTY + Sbjct: 155 LATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQL 214 Query: 2618 LEKADFDFHTGLKLL 2632 LE+ +GL LL Sbjct: 215 LERCVRAPGSGLALL 229 Score = 40.0 bits (92), Expect = 0.031 Identities = 75/334 (22%), Positives = 129/334 (38%), Gaps = 48/334 (14%) Query: 2341 VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH 2400 +VD G L V +A Q+ L+ LEL KE + + + D G Sbjct: 84 LVDLARGQLLPVSKALQQGLVG----LEL-------KEKLLAAERATTGY--PDPYGGEK 130 Query: 2401 FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLV-PKKDLHSPVAG----YWLTA 2455 + +AI + +D+AL + + E + L D LV P+ H + + L+ Sbjct: 131 LALFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSE 190 Query: 2456 SGERISVLKASRRNLVDRITALRCLEAQVSTGG---IIDPLT------GKKYRVAEALHR 2506 L+ N ++R+T + LE V G + PL G AE L Sbjct: 191 LEPGTGDLRFLNPNTLERLTYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEV 250 Query: 2507 GLVDEGFAQQLRQCELV-------------------ITGIGHPITNKMMSVVEAVNANII 2547 G++DE Q LR+ L + G+ S +A +++ Sbjct: 251 GILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLL 310 Query: 2548 NKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQ 2607 + LE Q T L++P RL ++EA++ G++ + +L + V P Sbjct: 311 PMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPF 370 Query: 2608 TKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTG 2641 + ++ +A++K D L+LL+ L TG Sbjct: 371 SGSQIPLFQAMKKGLVDRPLALRLLDAQ--LATG 402 Score = 39.7 bits (91), Expect = 0.040 Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 2/118 (1%) Query: 2524 ITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVG 2583 I G+ + + SV A+ ++ +G LE Q TGGL++ L + +ALQ G Sbjct: 43 IAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQQG 102 Query: 2584 IIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTG 2641 ++ + + KL + P KL +A+ K D G LEV L TG Sbjct: 103 LVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQ--LATG 158 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 179 bits (453), Expect = 4e-44 Identities = 357/1788 (19%), Positives = 747/1788 (41%), Gaps = 230/1788 (12%) Query: 248 NSLQTLKLMQIRKPLLKSSLLDQ---NLTEEE----INMKFVQDLLNWVDEMQVQLDRTE 300 N+L++LK Q LKS + ++ NL EE +F Q ++ + ++ T+ Sbjct: 968 NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027 Query: 301 WGSDLPSVESHLENHKNVHRAIEE-------FESSLKEAKISEIQMTAPLKLTYA--EKL 351 + +E + + I+E ES + E + + + +++T E+L Sbjct: 1028 TLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087 Query: 352 HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARK 411 L + K ++ H +SR + L + EK +E ++ + K Sbjct: 1088 RLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE--------KSQQLQEK 1139 Query: 412 KDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCV 471 + + E+ + ++ I ++ + +L + LT+E M+T+ L+L Q + Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKE----LTLEH----METER---LELAQKL 1188 Query: 472 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531 ++ +E K T + LK+ +Q+ + +R + ++ ++ KEEL Sbjct: 1189 NENYEE----------VKSITKERKVLKE-LQKSFETERDHLRGYIREIEATGLQTKEEL 1237 Query: 532 LQYKSTIANLMGKAKTIIQLKPRNSD--CPLKTSIPIKAICDYRQIEITIYKDDECVLAN 589 K +L +TI +L+ S+ + + ++ Q EI + +++ +L N Sbjct: 1238 ---KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294 Query: 590 NSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKS 649 K +S T E M T K++ LA RIE + + + ES +KS Sbjct: 1295 V------KEVSET-QETMNELELLTEQSTTKDSTTLA-RIEMERLRLNEKFQESQEEIKS 1346 Query: 650 VVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDIT 709 + N+ +IK L +H Q L+ + L QESQ + Sbjct: 1347 LTK-----------ERDNLKTIKEALEVKHDQ----LKEHIRETLAKIQESQSKQEQSLN 1391 Query: 710 QLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE 769 EK+ K ++ E+ + ++S E+ + RL+ D + + E Sbjct: 1392 MKEKDNETTK-----IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK---E 1443 Query: 770 RDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQA-AASSSVPTLRSELNVVL 828 +DDL QE L+ E ++LK+++ I K E + A + +N + Sbjct: 1444 KDDLQRL------QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497 Query: 829 QNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST 888 N+++ + ST +L+ +N L+N + ++YE EE+ I + ++ ++ Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKLQNK-----IQEIYEK---EEQFNIKQISEVQEKVNE 1549 Query: 889 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948 LKQ++ K ++E ++ + +++ + ++ +E + KE+ ++ E Q Sbjct: 1550 LKQFKEHRKAKDSALQSIESKMLE---LTNRLQESQEEIQIMIK-EKEEMKRVQEALQIE 1605 Query: 949 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008 Q+ +++ + K + Y L + V TQ K+ E + L Q Q Sbjct: 1606 RDQLKENTKEI--VAKMKESQEKEYQFLK--MTAVNETQEKMCEIEH-----LKEQFETQ 1656 Query: 1009 KMLVSEIEMKQSKMDEC--QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR----RR 1062 K+ + IE + ++ + + E S T + +L+++ V+ Q R R Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716 Query: 1063 MQSSADLII--------QEFMD----LRTRYTALVTLMTQYIKFAGDSLK----RLEEE- 1105 ++ +L I QE +D + + T ++ M + ++ + D+LK +++EE Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776 Query: 1106 -----EIKRCKETSE--HGAYSD----LLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 +K +ET + G S+ L QK N+KL KI EL+ +L K Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836 Query: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAES------------EAKQYRRELET 1202 V E KV E +L+KQ ++ + ++L K+ E+ E K +E + Sbjct: 1837 KDVNETQKKVSEM--EQLKKQIKD-QSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893 Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262 + R +E + E +++++ E +A+ +++ L R +E+ T L + + K + Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953 Query: 1263 LNDLEQQKNKLMEELRRK-RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR 1321 ++D+++ +K +EL++K ++ +++ L+L++ E ++ K++ E ++++ + Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE-----DVNMSHKKINEMEQLKKQFEA 2008 Query: 1322 KITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVD-------ELTAA 1374 + +Q +N + ++ + +++ ++ E LK + D E+ A Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR 2068 Query: 1375 NRKAEQDMRELTYELNALQLEKTSSEEKARLLKD------KLDETNNTLRCLKLELERKD 1428 +R+ Q E + Q S EK +K+ ++D+ L L L+LE++ Sbjct: 2069 DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128 Query: 1429 QAEKGYSQQLR-ELGRQLNQT-------TGKAEEAMQEASDLKKIKR--NYQLELESLNH 1478 + +K S +++ L QT T +M+ +KK+K +Y +++ H Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQH 2188 Query: 1479 EK-GKLQRE-VDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEK 1536 E K + + +D + + + K IQHL +EL L++ Q H++E + Sbjct: 2189 ESINKFEMDFIDEVEKQKELLIK-IQHLQQDCDV--PSRELRDLKLNQNMDLHIEEILKD 2245 Query: 1537 SHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAE 1596 E +IK E + Q L+ E + Q +EE + + + IQ E Sbjct: 2246 FSESEFPSIKTEFQ-----QVLSNRKE--------MTQFLEEWLNTRFDIEKLKNGIQKE 2292 Query: 1597 SENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKI----KCLEED 1652 ++ I R A+ ++ F+++ + ++ + K+ ++ K+ + L+ Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTS 2352 Query: 1653 LAKSQ--NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQ 1710 LA N ++ + + Q T +++R L L+ +KE E K+ Q +++ Sbjct: 2353 LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412 Query: 1711 ELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEE----SGKFKQSAEEFRKKMEKL----M 1762 N+ + K+Q ++H + T + + Q++ + +K+ E+ + K+ K+ M Sbjct: 2413 VTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM 2472 Query: 1763 ESKVITENDISGIRL------DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816 ++ E +IS + + + L +EN R + A+ +T++ Q + + Sbjct: 2473 KNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQ--DTSVISEHTDPQPSNKPLTC 2530 Query: 1817 GQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDC 1876 G K L+ E I ++E+ LKQ+ +Q IK+ L Q + T K+ Sbjct: 2531 GGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKER 2590 Query: 1877 TFKPDF--EMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLE 1922 T K + ++T + S +++ + TP R Q+P P E Sbjct: 2591 TLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKE 2638 Score = 169 bits (428), Expect = 3e-41 Identities = 301/1555 (19%), Positives = 622/1555 (40%), Gaps = 183/1555 (11%) Query: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSA-----EREEQEESVYNLYISE-VRN 748 +D + + S++ L K V Q + L S E+E+Q + + S+ + N Sbjct: 546 KDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLEN 605 Query: 749 IRL----RLENCED-RLIRQIRTPLER---DDLHESVFRITEQEKLKKELERLKDDLGTI 800 I++ LE+ ED + ++Q E D ES F +E +LK++++ L + Sbjct: 606 IKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQM 665 Query: 801 TNKCEEFFSQAAASSSVPT-LRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVL--KNTQA 857 N + + SQ A + L EL + ++ S+ + K NL L K T Sbjct: 666 ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725 Query: 858 AEALVK-LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI 916 + L K + E + EE ++ + +++L S +++ R E+ +K + H + E K K Sbjct: 726 QKELNKEVEENEALREEVILLSE--LKSLPSEVERLRKEIQDKSEELHIITSE--KDKLF 781 Query: 917 SDEMFKTYKERDLDFDWHKEK------------ADQLVERWQNVHVQIDNR----LRDLE 960 S+ + K + + L + K K DQ + ++ +H+ + + L + E Sbjct: 782 SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 841 Query: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020 + + + D + ++T + E ++ + +LN+ + L ++E + S Sbjct: 842 RMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 901 Query: 1021 KMDECQK----YAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076 + ++ E+ T+++ + T + Q+ ++R +++S + +D Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961 Query: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKL 1136 + + + + Q+ + ++ EE + G D Q++ + + L Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021 Query: 1137 TGK-------------ISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDIS 1183 K I E +R + L ++K+ +++ L V E + N+E Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081 Query: 1184 LQKIRAESEAKQYRRELETIVREKEAA---ERELERVRQLTIEAEAKRAAVEENLLNFRN 1240 + + +++ E + +EK A E EL R + A VEE L Sbjct: 1082 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD-------RLAEVEEKLKEKSQ 1134 Query: 1241 QLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAF 1300 QL+E +++ + +N++E KN+L + E E L+L +++ ++ Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194 Query: 1301 QKQVAE--KQLKEKQK-IELEA---RRKITEIQYTCRENALPVCPITQATSCRAVTGLQQ 1354 K + + K LKE QK E E R I EI+ T Q + + Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYIREIEATG----------LQTKEELKIAHIHL 1244 Query: 1355 EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD--KLDE 1412 + ++ +EL++ V E TA + +L LQ E E+ LL + ++ E Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQ----DLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300 Query: 1413 TNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLE 1472 T T+ L+L E+ + ++ +LN+ K +E+ +E L K + N + Sbjct: 1301 TQETMNELELLTEQSTTKDSTTLARIEMERLRLNE---KFQESQEEIKSLTKERDNLKTI 1357 Query: 1473 LESLNHEKGKLQREV-DRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHL- 1530 E+L + +L+ + + + + K Q LN + K + ++ + K L Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417 Query: 1531 ---------KEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTR 1581 ++ ++SH+++ K+ + D +QRL E L+ ++ LK+ ++E+ Sbjct: 1418 RIEIEMLGLSKRLQESHDEM----KSVAKEKDDLQRLQEVLQSESD---QLKENIKEIVA 1470 Query: 1582 QNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQD 1641 ++ ET+ E LK+ K+Q + NE ++ E + Sbjct: 1471 KHLETE------------------------EELKVAHCCLKEQEETINELRVNLSEKETE 1506 Query: 1642 FQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQK 1701 K LE K QN + E +K +Q NI EV+ EL KE ++ + Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEEQFNI---KQISEVQEKVNELKQFKEHRKAKDSA 1563 Query: 1702 VQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL 1761 +Q ++++ EL NRL++ Q+E+ + E++ R Q E + K++ +E KM++ Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623 Query: 1762 MES-----KVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816 E K+ N+ + L+++ + N + ET L + L + E+M+ Sbjct: 1624 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1683 Query: 1817 -----------GQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQC 1865 + ++ Q + L + + + E LK + +KEH+ + L+ Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELK-IVHMHLKEHQETIDKLRG 1742 Query: 1866 EIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKW 1925 + +K+ + K+ +HS + + R + +E Q +K Sbjct: 1743 IVSEKTN--------EISNMQKDLEHSNDALKAQDLKIQEELRIAHMH-LKEQQETIDKL 1793 Query: 1926 QHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIE-- 1983 + V E+ K Q K Q+ E + + + D ++SE+E Sbjct: 1794 RGIVSEKTDKLSNMQ-KDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1852 Query: 1984 --KIRDQALNNSRPPVRYQDNACEM-----ELVKVLTPLEIAKNKQYDMHTEVTTLKQEK 2036 +I+DQ+L S+ + + A ++ E+ V+ + + + + E LK+ Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912 Query: 2037 NPVPSAEEWMLEGCRASGGLKKG-----DFLKKGLEPETFQNFDGDHACSVRDDEFKFQG 2091 + + + + + + L K D L++ + +T Q D DE Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE----- 1967 Query: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLES 2146 L+ + Q E +LL R E + + K + E+++ +F + S+ + +++ Sbjct: 1968 LQKKIQELQKKELQLL--RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDN 2020 Score = 90.9 bits (224), Expect = 2e-17 Identities = 203/1053 (19%), Positives = 410/1053 (38%), Gaps = 191/1053 (18%) Query: 1251 TLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQ------- 1303 T E LKR + DL++Q ++ E R + +++L +L++ EKDL + Q Sbjct: 340 TDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE--EKDLLQKVQNEKIENL 397 Query: 1304 ----VAEKQLKEKQKIELEARRKIT----------------------------------- 1324 V L +Q+++ + +R++T Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457 Query: 1325 --EI-QYTCRENAL---PVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKA 1378 EI + C E+ + + +++ A L QE+ + + L+ D L + Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517 Query: 1379 EQDMRELTY---------ELNALQLEKTSSEEKARLLKD--------------KLDETNN 1415 + E+ E AL+ KT +++ +L+ + D N Sbjct: 518 RTEKEEMELKLKEKNDLDEFEALE-RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENE 576 Query: 1416 TLRCLKLELERKDQAEKGY----SQQLRELGRQLNQTTGKAEEAMQEAS---DLKKIKRN 1468 ++L E++DQ +K SQ+L + L+ + E+ Q D + + + Sbjct: 577 LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636 Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD-EKELER-LQICQRK 1526 + E L E +L+ ++ + + E +IQ SQ+ + + + +LE+ LQ + Sbjct: 637 AKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696 Query: 1527 SDHLKEQFE-KSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAE---------MLKQKV 1576 L + K + LL N++ E + D + LN+E+E++ E L +V Sbjct: 697 ITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEV 756 Query: 1577 EELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQT 1636 E L ++ + + I +E + + E + R + L + KD L +T + Sbjct: 757 ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN---YK 813 Query: 1637 KTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKR 1696 T+Q+FQ K L D + +V E ++ +Q+ I N KE + ++ L A K E Sbjct: 814 STDQEFQ-NFKTLHMDFEQKYKMVLEENERMNQE---IVNLSKEAQKFDSSLGALKTELS 869 Query: 1697 RGEQKVQLQQAQVQELNNRLKKVQDELH-----LKTIEEQMT--HRKMVLFQEESGKFKQ 1749 Q++Q + +VQE N +++++++L L+T+E + T K+ EE Q Sbjct: 870 YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929 Query: 1750 SAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQ 1809 ++ ++ E L + ++DI + Q++ A E+ K + I L+ ++ Sbjct: 930 EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKIS- 988 Query: 1810 YREQMQQGQHMEANHYQKCQKLEDELI-------------------AQKREVENLKQKMD 1850 E++ + HME N + + + +++ + E+ ++K+ Sbjct: 989 --EEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIF 1046 Query: 1851 QQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVK----------ECQHSGELSSRNT 1900 I+E +L+ I +K K K + EMT++ E + E+ ++ Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLK-TDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105 Query: 1901 GHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFS 1960 H L R +EEK + K Q Q EK QQ + Sbjct: 1106 NHA-IKKEGELSRTCDRLAEVEEKLKE-------KSQQLQ--------EKQQQLLN--VQ 1147 Query: 1961 QTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKN 2020 + +E+Q +E + + +++ + + R + + N E+ + ++ K Sbjct: 1148 EEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKE 1207 Query: 2021 KQYDMHTEVTTLKQ-----EKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFD 2075 Q TE L+ E + + EE + + D L++ + +T Q Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ--- 1264 Query: 2076 GDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLN--KFL 2133 + +D E L+ + + ++L +K V E Q+T+N + L Sbjct: 1265 ---IINTQDLEKSHTKLQEEIPV----------LHEEQELLPNVKEVSETQETMNELELL 1311 Query: 2134 TK------ATSIAGLYLESTKEKISFASAAERI 2160 T+ +T++A + +E + F + E I Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEI 1344 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 171 bits (432), Expect = 1e-41 Identities = 264/1306 (20%), Positives = 547/1306 (41%), Gaps = 163/1306 (12%) Query: 726 LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785 L+S E++ +E N I +++++ E +L +I + D S+ EQ K Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDL---FEQKAAQLATEIADIKSKYDEERSLREAAEQ-K 192 Query: 786 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845 + + E L + I + E Q V L+ EL V M+ + +KL Sbjct: 193 VTRLTEELNKEATVIQDLKTELL-QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251 Query: 846 KTVNLVLKNTQAA-EALVKLYETKLC---EEEAV-IADKNNIENLISTLKQWRSEVDE-- 898 K L++ A+ EA + ++L +E AV + + +++ ++ L Q + E Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311 Query: 899 --KRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956 K Q + LE++ + + T ++DLD + + +HV++ + Sbjct: 312 LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG 371 Query: 957 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN----QPE----NSKTLATQ---- 1004 + + + L Y L +Q++ + + +++ Q E +SK L T+ Sbjct: 372 EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431 Query: 1005 -----LNQQKMLVSEIEM-KQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058 L +Q+ L SE M K+ ++ + Q + +K+ + + +D ++ Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ 491 Query: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGA 1118 +++ +Q S ++E + + Q ++ GD ++++ E Sbjct: 492 EQQALQQSTTAKLREAQND----------LEQVLRQIGDKDQKIQNLEA----------- 530 Query: 1119 YSDLLQRQKATVL----ENSKLTGKISELERMVA---ELKKQKSRVEEELPKVREAAENE 1171 LLQ+ K + E L KI E A +L+++ ++E++ ++ E +N+ Sbjct: 531 ---LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587 Query: 1172 L---RKQQRNVEDISLQKIRAESEAKQYR-RELETIVREKEAAEREL-ERVRQLTIEAEA 1226 ++ Q N+ D +Q+ +A A Q R LET V E + E E+V QL I+ +A Sbjct: 588 SESHKQAQENLHD-QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646 Query: 1227 K--------------RAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNK 1272 K RA ++ +L +N L++ + L + L D ++ ++ Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706 Query: 1273 LMEELRRKRDN-------EEELLKLIKQMEKD---LAFQKQVAEKQLKEKQKIELEARRK 1322 L L+ ++ EEL IK++E D + K+ A + L++++++ + + Sbjct: 707 LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766 Query: 1323 ITEI--QYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEE--LKQQVDELTAANRKA 1378 TE+ Q + + + A+ ++Q+ KQ+ E+ LKQ + L+ + Sbjct: 767 ATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826 Query: 1379 EQDMRE----LTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGY 1434 +++ EL +++EK + + +KDKL + +++L+ K E E+++Q K Sbjct: 827 HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886 Query: 1435 SQQLRELGRQL-NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRA 1493 L + ++L +Q + E ++E +LKK + L E +Q ++ + Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946 Query: 1494 HAVAEKNIQHLNSQIHSFRD-----EKELERLQ----ICQRKSDHLKEQFEKSHEQLLQN 1544 EK Q L I+ + +K++E LQ I + L+ + ++ Q Q Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE 1006 Query: 1545 IKAEKENNDKIQRLNEELEKSNECAEMLKQ----KVEELTRQNNETKLMMQRIQAESENI 1600 + AEKE KI L EKS E + L+ + EL + K + +++ E++ Sbjct: 1007 LAAEKE---KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063 Query: 1601 VLEKQTIQQR---CEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657 + + I + + LK + + L ++ K QD Q++ E++L + Sbjct: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123 Query: 1658 NLVSEFKQ-KCDQQNIIIQNTKKEVRNLNAELNASKEEK-------RRGEQKVQLQQAQV 1709 + ++E ++ KC Q+ KE+ LN EL + K E + +Q + Q+ ++ Sbjct: 1124 SKLAEIEEIKCRQE--------KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175 Query: 1710 QELNNRLKKV--QDELHLKTIEEQMTHRKMVL---FQEESGKFKQSAEEFRKKMEKLMES 1764 Q + LK Q++ + + +++Q+ + L F E+ K +E M+K E+ Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1235 Query: 1765 KVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANH 1824 + I+ + + ++++E +Q E +L ++ +Q Q Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295 Query: 1825 YQKCQKLEDELIAQKREVENLKQKMD------QQIKEHEHQLVLLQCEIQKKSTAKDCTF 1878 ++C K E E+ + +V L++K+D Q++ L + + + A+D Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355 Query: 1879 K------PDFEMTVK--ECQHSG-----ELSSRNTGHLHPTPRSPL 1911 + F +TV+ C+ G E S++N L P+ + P+ Sbjct: 1356 QNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNA--LTPSSKKPV 1399 Score = 142 bits (357), Expect = 6e-33 Identities = 243/1171 (20%), Positives = 466/1171 (39%), Gaps = 168/1171 (14%) Query: 1105 EEIKRCKETSEHGAYSDL-LQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPK 1163 E + S HG S+L L+R T+L E++ + A LK++K EE Sbjct: 61 EAVHDAGNDSGHGGESNLALKRDDVTLLRQ--------EVQDLQASLKEEKWYSEE---- 108 Query: 1164 VREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIE 1223 L+K+ + + Q+ + + EL+++ ++ E A+ E ++Q+ Sbjct: 109 --------LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160 Query: 1224 AEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDN 1283 E K A + + + +++ +E R E + R LN L EL +R Sbjct: 161 FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL-LQRPG 219 Query: 1284 EEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQA 1343 E++ L K++ + + ++ +E +K++ E ++ + QY E + A Sbjct: 220 IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK--LQSQYASSEATISQLRSELA 277 Query: 1344 TSCRAVTGLQQEHDKQKA--EELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS--- 1398 + V QE K K+ EL Q+ LT K EQD +L + N + K + Sbjct: 278 KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337 Query: 1399 ----SEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEE 1454 + + L+ +L + +L + +EL K +A + ++L E+ + + ++ Sbjct: 338 TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 397 Query: 1455 AMQEASDLKKIKRNYQLELESLNHEKGKLQREV---------DRITRAHAVAEKNIQHLN 1505 Q+ + ++ Q E+ L+ + + +R++ R + + +K Q + Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457 Query: 1506 SQIHSFRDEKELE---------RLQICQRKSDHLKEQ---------FEKSHEQLLQNIKA 1547 Q+ R E++L+ + Q+ + K H ++Q ++ L Q ++ Sbjct: 458 LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517 Query: 1548 EKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQA-ESENIVLEKQT 1606 + + KIQ L L+KS E +L+++ E+L +IQA E E VL + Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDL----------YAKIQAGEGETAVLNQ-- 565 Query: 1607 IQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQK 1666 +Q++ L+ Q ++L++ +E HKQ +++ +++ + L +Q+ V + Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSES-HKQ--AQENLHDQVQEQKAHLRAAQDRVLSLETS 622 Query: 1667 CDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQE----LNNRLKKVQDE 1722 ++ N + +K++V L+ ++ A E E Q+A +Q N L+ Q E Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682 Query: 1723 LHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSL 1782 L+ T + K+ QE + + +E+++K L + E I + D + + Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742 Query: 1783 QQENSRA----QENAKL---CETNIKELERQLQQYRE-------QMQQGQHMEANHYQKC 1828 + +A Q+ +L E EL +QL+ +E +Q+ + QK Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802 Query: 1829 QKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQK-----------KSTAKDCT 1877 K E+E K++ E L Q+ Q +E +++ E+QK ST KD Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862 Query: 1878 FKP-----------------------DFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRW 1914 K D E T KE +H ++ NT + L + Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922 Query: 1915 TQEPQPLE---EKWQHRVVE------QIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTE 1965 + L+ Q ++++ Q KE Q Q G E ++S + + E Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ-QLQGNINELKQSSEQKKKQIEALQGE 981 Query: 1966 LQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVL-----TPLEIAKN 2020 L+I + + +E+E Q L + Q+ A E E + VL E K Sbjct: 982 LKIA------VLQKTELENKLQQQLTQAA-----QELAAEKEKISVLQNNYEKSQETFKQ 1030 Query: 2021 KQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKK----GLEPETFQNFDG 2076 Q D + + L + + S EE + L + D + G + + Q Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKL--------SLAQEDLISNRNQIGNQNKLIQELKT 1082 Query: 2077 DHACSVRDDEFKFQGLRHTVTARQ-LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTK 2135 A +D K Q L+ A Q + + K L + + + L +EE++ K +TK Sbjct: 1083 AKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITK 1142 Query: 2136 AT-SIAGLYLESTKEKISFASAAERIIIDKM 2165 + LES KE + A + +I K+ Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173 Score = 55.1 bits (131), Expect = 9e-07 Identities = 150/800 (18%), Positives = 323/800 (40%), Gaps = 129/800 (16%) Query: 309 ESHLENHKNVHRAIEEFESSLK---------EAKISEI--------QMTAPLKLTYAEKL 351 ESH + +N+H ++E ++ L+ E ++E+ + + L + K Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648 Query: 352 HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARK 411 L S A + + HLDT N + EL ++ + + K Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL--------NKITTQLDQVTAKLQDK 700 Query: 412 KDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCV 471 +++ ++L L + +E S+++ E+ LE +L ++ + Q Q + Sbjct: 701 QEHCSQLESHLKEYKEKYLSLEQKTEE--LEGQIKKLEADSLEVKASKE-----QALQDL 753 Query: 472 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ--RKYSCDRSSSIHKLEDLVQESMEEKE 529 +Q + NT + A E + L K+ + R +S ++ ++ + + EEK+ Sbjct: 754 QQQRQLNT---DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810 Query: 530 ELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI----PIKAICDYRQIEITIYKDDEC 585 L Q T++ +T IQ + N+ ++T++ +K + E++ KD Sbjct: 811 ILKQDFETLSQ-----ETKIQHEELNN--RIQTTVTELQKVKMEKEALMTELSTVKDKLS 863 Query: 586 VLANN--SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHES 643 ++++ + +++++ + G A++ K +L ++++ Q +N L E Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDL--------EKTCKELKHQLQVQMENTLKEQKEL 915 Query: 644 HINM-KSVVSWHYLINEIDRIRASNVASIKTMLPG--EHQQVLSNLQSRFEDF------- 693 ++ K + H L E++ ++ + + T+ E QQ+ N+ + Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975 Query: 694 ----------------LEDSQESQVFSGSDITQLEKE-VNVCKQYYQELLKSAEREEQEE 736 LE+ + Q+ + EKE ++V + Y+ KS E +Q + Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE---KSQETFKQLQ 1032 Query: 737 SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDD 796 S + SE+ R L++ E++L L ++DL + +I Q KL +EL+ K Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKL------SLAQEDLISNRNQIGNQNKLIQELKTAKAT 1086 Query: 797 LGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--DKLKTVNLVLKN 854 L + K E+ + + LQ++ + S+ + +K K + Sbjct: 1087 LEQDSAKKEQQLQERCKA-------------LQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133 Query: 855 TQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH-ALEDELQKA 913 + + + KL E + I + N+++ L Q + E+ K A+E E + Sbjct: 1134 CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193 Query: 914 KAISDEMFKTYKERDLDF-----DWHKEKADQLV--ERWQNVHVQIDNRLRDL-EGIGKS 965 + + D++ K +E +F H E ++ V ++ + ++ ++ L E +G Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV 1253 Query: 966 LKYYRDTYHPL-------DDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1018 K ++ + + DD ++ + +Q NQ E L L + EIE Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE----GEIEKL 1309 Query: 1019 QSKMDECQKYAEQYSATVKD 1038 Q+K+ E Q+ + +A V++ Sbjct: 1310 QTKVLELQRKLDNTTAAVQE 1329 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 161 bits (407), Expect = 9e-39 Identities = 294/1370 (21%), Positives = 566/1370 (41%), Gaps = 192/1370 (14%) Query: 680 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739 Q++ + R E L+ + ++ Q K ++ Q+LLKS E+EE+ + Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647 Query: 740 NLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGT 799 E R RL+ E E+RL ++++ HE R EQE ++E E+ ++ + + Sbjct: 648 RREQQERREQRLKREEEEERLEQRLKRE------HEEERR--EQELAEEEQEQARERIKS 699 Query: 800 ITNKCE-EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858 K + + S+A A S +VYS + + + Q Sbjct: 700 RIPKWQWQLESEADARQS----------------KVYSRPRKQEGQRR------RQEQEE 737 Query: 859 EALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV----------------DEKRQV 902 + + E + EEE + E QW++E +++ + Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797 Query: 903 FHALEDELQKAKAISDEMFKTYK-------ERDLDFDWHKEKADQLVERWQNVHVQIDNR 955 A E + ++ + + +E K + E++L F +E+ Q ER Q + + D Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF-LEEEEQLQRRERAQQLQEEEDGL 856 Query: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015 D E +S + RD W Q+E +RK + + L QL +++ L+ E Sbjct: 857 QEDQER-RRSQEQRRD-----QKWRWQLEE-ERKRRRHTLYAKPALQEQLRKEQQLLQEE 909 Query: 1016 EMK-QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR--------RMQSS 1066 E + Q + E ++ EQ ++ +LQ + + + ++K + R ++Q Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969 Query: 1067 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQ 1126 + ++ E + R R + + EE E +R +E D LQ++ Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029 Query: 1127 KATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAEN-ELRKQQRNVEDISLQ 1185 + +L + ++ E ER E ++ + E+ L + RE EL +Q R E++ + Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE 1089 Query: 1186 K---IRAESEAKQYRRELETIVREKEAAERELERV----RQLTIEAEAKRAAVEENLLNF 1238 + +R E E K+ R+E E RE+E ++E E++ R+ E +R EE + Sbjct: 1090 EEQLLREEPE-KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148 Query: 1239 RNQ--LEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEK 1296 + L E RR E L+R+ +L+Q++ +L+ E + KR E E +Q + Sbjct: 1149 EEEQLLREEPEKRRRQE--LERQYREEEELQQEEEQLLREEQEKRRQERE-----RQYRE 1201 Query: 1297 DLAFQKQVAEKQLKEKQKIELEARRKITEIQYTC-RENALPVCPITQATSCRAVTGLQQE 1355 + Q+Q K KQ+ E +R + Q+ +ENA+ + Sbjct: 1202 EEELQRQ------KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV--------------- 1240 Query: 1356 HDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLL-KDK-LDET 1413 + K + E +Q+++ +R+++QD++ L E Q E+ +E+ R +D+ E Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE----QQERDREQERRRWQQRDRHFPEE 1296 Query: 1414 NNTLRCLKLELERKD---QAEKGYSQQLRELGRQLNQTTGKAEEAMQ-----EASDLKKI 1465 R + E +R+D Q EK ++ RE R+ +T K E Q E L++ Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356 Query: 1466 KRNYQLELESLNHEKG--KLQREVDRITRAHAVA-------EKNIQHLNSQIHSFRDEKE 1516 +R+ + E L H++ K E R+ R + Q Q+ RD K Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416 Query: 1517 LERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKV 1576 E Q R+ +++ + EQ ++ + E++ ++ Q+L +E + E L Q+ Sbjct: 1417 REEEQQLSRQE---RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473 Query: 1577 EE------------------LTRQNNETKLMMQRIQA-ESENIVLEKQTI---QQRCEAL 1614 EE L RQ + K Q +++ E E LE++ QQR Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533 Query: 1615 KIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQN----LVSEFKQKCDQQ 1670 + + Q R + K ++ Q + + E+ L++ + + E K + +Q Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593 Query: 1671 NIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQL------QQAQVQELNNRLKKVQDELH 1724 ++++R + +E R+ + QL QQ QE + + + + +L Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653 Query: 1725 LKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQ 1784 + E+Q+ H + F+EE ++ E+ ++ E+ + K E ++ Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER--DRKFREEEQ------QLRRQER 1705 Query: 1785 ENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVEN 1844 E QE +L ++ R+ +Q R++ +Q Q Y+K LE+E + +RE + Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI--LEEEQLRPEREEQQ 1763 Query: 1845 L-KQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHL 1903 L +Q+ D++ +E E QL + E Q +S D F+ + ++ R L Sbjct: 1764 LRRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFREEEQLR----------QEREEQQL 1812 Query: 1904 HPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQ 1953 P R RW +E LEE+ + R+ ++ ++ + + A EK + ++ Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQ-EQRLRQERDRQYRAEEQFATQEKSRREE 1861 Score = 155 bits (391), Expect = 7e-37 Identities = 211/1025 (20%), Positives = 450/1025 (43%), Gaps = 107/1025 (10%) Query: 978 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK 1037 DW+++ E T+R QE + + K + +++ L E E ++ + + ++ + + Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515 Query: 1038 DYELQTMTYRAMVDSQQKSPVKRRRMQSSA-DLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096 + L+ + + +S + RR Q + +++ + R + + + Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575 Query: 1097 DSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSR 1156 D L + EEE ++ + + L+R++ LE + + + E E ++Q + Sbjct: 576 DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635 Query: 1157 VEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQ-YRRELETIVREKEAAERELE 1215 EE+ E + +LR++Q+ + L++ E +Q +RE E RE+E AE E E Sbjct: 636 SEEQ----EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691 Query: 1216 RVR------------QLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSL 1263 + R QL EA+A+++ V R + +E R+ E+ +R++ L Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYS-----RPRKQEGQRRRQEQEEKRRRRESEL 746 Query: 1264 NDLEQQK---NKLMEELRRK------------------------RDNEEELLKLIKQMEK 1296 E+++ + EE RR R+ E L+ ++ ++ Sbjct: 747 QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806 Query: 1297 DLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEH 1356 + F + EK+ + +Q+ E E E+Q+ E L Q GLQ++ Sbjct: 807 EQRFLPEEEEKEQRRRQRREREK-----ELQFLEEEEQLQRRERAQQLQ-EEEDGLQEDQ 860 Query: 1357 DKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNT 1416 ++++++E Q+ D+ + E+ R T K + +E+ R + L E Sbjct: 861 ERRRSQE--QRRDQKWRWQLEEERKRRRHTL------YAKPALQEQLRKEQQLLQEEEEE 912 Query: 1417 LRCLKLELERKDQAEKGY--SQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE 1474 L+ + E R+ + E+ Y +QL++ QL + + + +K K+ Q E + Sbjct: 913 LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972 Query: 1475 SLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQF 1534 L E K +R+ +R + E+ +Q Q+ R+E+E R Q +R+ K++ Sbjct: 973 LLGEEPEKRRRQ-EREKKYRE--EEELQQEEEQL--LREEREKRRRQEWERQY-RKKDEL 1026 Query: 1535 EKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQR-I 1593 ++ EQLL+ + ++ ++ ++ EE E E ++L ++ E RQ E + + + Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086 Query: 1594 QAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHL---HKQTKTEQDFQRKIKCLE 1650 Q E E ++ E+ ++R E + + +++L+ E L ++ + Q+ +R+ + E Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCRE--EEELQQEEEQLLREEREKRRRQELERQYREEE 1144 Query: 1651 EDLAKSQNLVSEFKQKCDQQNIIIQ-NTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQV 1709 E + + L+ E +K +Q + Q ++E++ +L ++EKRR E++ Q ++ + Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204 Query: 1710 QELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK-QSAEEFRKKMEKLMESKVIT 1768 + R ++ +DE ++ Q K ++ K + E+FR+ + + + + Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ-S 1263 Query: 1769 ENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKC 1828 + D+ + + QQE R QE + ++ +R + EQ+++ + EA + Sbjct: 1264 QQDLQHL----LGEQQERDREQERRRW-----QQRDRHFPE-EEQLEREEQKEAKRRDRK 1313 Query: 1829 QKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKE 1888 + E +L+ ++RE + +Q+ D++ +E E QL+ + E + +D F+ + Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFRE-EEQLLQEREEQPLRRQERDRKFREE------- 1365 Query: 1889 CQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEK 1948 EL + G L R +E + L+E+ Q R E +E Q + + Sbjct: 1366 -----ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE---REQQLRQDRDRKFR 1417 Query: 1949 EKSQQ 1953 E+ QQ Sbjct: 1418 EEEQQ 1422 Score = 149 bits (377), Expect = 3e-35 Identities = 282/1390 (20%), Positives = 597/1390 (42%), Gaps = 171/1390 (12%) Query: 680 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEK--EVNVCKQYYQELLKSAEREEQEES 737 +Q L Q D+L+ +E++ Q K + ++ + +L + RE+QE Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503 Query: 738 VYNLYIS--EVRNIRLRLENCEDRLIRQIRTPL----ERDDLHESVFRITEQ-------- 783 L E R RL+ + E+RL +++R+ E+++ E + + E+ Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563 Query: 784 -EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL-----RSELNVVLQNMNQVYSM 837 ++LK+E E +D L + EE Q L R E+ + Q + + Sbjct: 564 EQRLKREQEERRDQL---LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620 Query: 838 SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897 ++ + L+ Q +L + E + + E L LK+ E + Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR---EHE 677 Query: 898 EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKE-KADQLVERWQNVHVQIDNRL 956 E+R+ E+E ++A+ + K R + W E +AD + + + + + Sbjct: 678 EERREQELAEEEQEQAR-------ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730 Query: 957 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1016 R E K + + W Q+ E R+ QE + T Q ++ E Sbjct: 731 RRQEQEEKRRRRESEL-----QW-QEEERAHRQQQEEEQRRDFTWQWQAEEKS------E 778 Query: 1017 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADL-IIQEFM 1075 + ++ EQ ++ E Q R + + ++K +R+R + +L ++E Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838 Query: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ----RQKATVL 1131 L+ R A Q ++ D L+ E++E +R +E + L+ R++ T+ Sbjct: 839 QLQRRERA------QQLQEEEDGLQ--EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890 Query: 1132 ENSKLTGKISELERMVAELKKQKSRVEEELPKVRE-----AAENELRKQQRNVEDISLQK 1186 L ++ + ++++ E +++ R E E + +E E +L++++ + +K Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950 Query: 1187 IRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQL--EE 1244 R + +QYR++ + +E++ E E+ R+ + K+ EE L QL EE Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR---QEREKKYREEEELQQEEEQLLREE 1007 Query: 1245 NTFTRR-------TLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQM--E 1295 RR +D L++++ L E++K +L E R+ R+ EEEL + +Q+ E Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEELQQEEEQLLGE 1066 Query: 1296 KDLAFQKQVAEKQLKEKQKIELEARRKI-TEIQYTCRENALPVCPITQATSCRAVTGLQQ 1354 + ++Q E+Q +++++++ E + + E + R+ C + L++ Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126 Query: 1355 EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN 1414 E +K++ +EL++Q E ++ EQ +RE + +LE+ EE ++L + Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE------EELQQEE 1180 Query: 1415 NTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE 1474 L L+ E E++ Q + ++ EL RQ + + E+ + SDLK +Q E E Sbjct: 1181 EQL--LREEQEKRRQERERQYREEEELQRQKRKQRYRDED---QRSDLK-----WQWEPE 1230 Query: 1475 SLN-------HEKGKLQ---REVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQ 1524 N + KG+ R+++ +++++QHL + E+E R Q Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR---WQ 1287 Query: 1525 RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNN 1584 ++ H E+ + E+ + + ++++ ++ Q L EE E+ K++ +E R+ Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE--------KRRRQETDRKFR 1339 Query: 1585 ETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFK----DQLRSTNEHLHKQTKTEQ 1640 E + ++Q + E + + +++ + R E L+ Q G K +Q E K K EQ Sbjct: 1340 EEEQLLQ--EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ 1397 Query: 1641 DFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQ 1700 +++C E + Q+ +F++ ++Q + Q ++ R ++ + E++ E+ Sbjct: 1398 ----QLRCQEREQQLRQDRDRKFRE--EEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451 Query: 1701 KVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRK--KM 1758 + QL+Q + ++ ++E L+ EEQ HR QE KF + ++ R+ + Sbjct: 1452 EQQLRQERHRKFR------EEEQLLQEREEQQLHR-----QERDRKFLEEEQQLRRQERD 1500 Query: 1759 EKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQ 1818 K E ++ ++ F+ +Q+ R Q K + ++L RQ + + + + + Sbjct: 1501 RKFREQELRSQEP----ERKFLEEEQQLHRQQRQRKFLQEE-QQLRRQERGQQRRQDRDR 1555 Query: 1819 HMEANHYQKCQKLEDELIAQKR-------EVENLKQKMDQQIKEHEHQLVLLQCEIQKKS 1871 + ++ E +L Q+R E + +Q+ +++ E E QL + + Q+ Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ-QQLR 1614 Query: 1872 TAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTP------RSPLLR------WTQEPQ 1919 +D F+ D ++ + + R+ L P R LR + +E Q Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674 Query: 1920 PLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQ-TSTELQITFDETNPITR 1978 L+E + ++ Q ++ +F+ L +++ ++ + + Q EL+ F E + + Sbjct: 1675 LLQEGEEQQLRRQ-ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733 Query: 1979 LSEIEKIRDQ 1988 +E E++R Q Sbjct: 1734 ETEQEQLRRQ 1743 Score = 148 bits (374), Expect = 6e-35 Identities = 213/1030 (20%), Positives = 455/1030 (44%), Gaps = 114/1030 (11%) Query: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1061 AT L+++K + + K+S + + ++ +Q +D +L+ + +Q+ +R Sbjct: 92 ATGLDEEKR--ARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ--ERE 147 Query: 1062 RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK--ETSEHGAY 1119 + QE ++ R R L Q ++ +R EEE+++ CK ET E Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207 Query: 1120 SDLLQRQKATVLENSKLTGKISELERMVAELKKQKSR------VEEELPKVREAAENELR 1173 L +R+ + EL R E K+Q+ R +EE K E LR Sbjct: 208 EQLRRRE-------------LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254 Query: 1174 KQQRNVEDISLQKIRAESEAKQYRRELE--TIVREKEAAERELERVRQLTIEAEAKRAAV 1231 K++ +++ Q+ R E ++ R+LE + RE++ E++ +R+R+ E + +R Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR---EQQLRRKQE 311 Query: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI 1291 EE R Q EE + E +R++ L +Q+ + ++LRR+++ E +L Sbjct: 312 EER----REQQEERREQQERREQQEERREQQLR--REQEERREQQLRREQEEERREQQLR 365 Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKI----ELEARRKITEIQYTCRENALPVCPITQATSCR 1347 ++ E++ Q+ E+QL+ +Q++ +L +++ Q RE L + R Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL-----RREQQLR 420 Query: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLK 1407 L++E ++++ E+ +Q E K EQ+ R + K +L + Sbjct: 421 REQQLRREQEEERHEQKHEQ--ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478 Query: 1408 DKLDETNNTLRCLKLELERKDQAEKGYSQQLR--------------ELGRQLNQTTGKAE 1453 D+ +E R LKLE E + + ++ QQLR E +L Q + Sbjct: 479 DQEEERRE--RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536 Query: 1454 EAMQEASDLKK--IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511 + +E + ++ +KR + LE E+ +L+RE + R + ++ + ++ Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQ-RLKREQEE--RRDQLLKREEERRQQRLKRE 593 Query: 1512 RDEK--------ELERLQICQRKSDHLK--EQFEKSHEQLLQNIKAEKENNDKIQRLNEE 1561 ++E+ E+ERL+ +R+ LK E E+ +QLL++ + E+ +++R +E Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653 Query: 1562 LEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLE--KQTIQQRCEALKIQAD 1619 + E ++++E+ ++ +E + Q + E + E K I + L+ +AD Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713 Query: 1620 GFKDQLRSTNEHLHKQTKTEQDFQRK------IKCLEEDLAKSQNLVSEFKQKCDQQNII 1673 + ++ S Q + ++ +++ ++ EE+ A Q E ++ Q Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773 Query: 1674 IQNTKKEVRNLNA--------ELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725 + +++ + L+A E EE+++ EQ+ ++ + ++ + ++ + EL Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833 Query: 1726 KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFV----- 1780 EEQ+ R+ +E Q +E R+ E+ + K + + R Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893 Query: 1781 SLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKR 1840 +LQ++ + Q+ + E ++ ER+ ++ +EQ +Q + E ++ Q L +E ++R Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953 Query: 1841 EVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQ---------- 1890 + + + D+++++ E QL+ + E +++ ++ ++ + E+ +E Q Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPE-KRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012 Query: 1891 -HSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEK-WQHRVVEQIPKEVQFQPPGAPLEK 1948 E R L LLR +E + L+E+ Q+R E++ +E + Q G E Sbjct: 1013 RQEWERQYRKKDELQ-QEEEQLLREEREKRRLQERERQYREEEELQQEEE-QLLGEERET 1070 Query: 1949 EKSQQCYSEY 1958 + Q+ +Y Sbjct: 1071 RRRQELERQY 1080 Score = 137 bits (346), Expect = 1e-31 Identities = 247/1189 (20%), Positives = 486/1189 (40%), Gaps = 146/1189 (12%) Query: 907 EDELQKAKAISDEMF-----KTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961 E++ Q+ + D +F K +++R+ +EK + + Q + + +LR LE Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283 Query: 962 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021 + L+ R +++ + +RK +E + E + Q Q++ E +Q Sbjct: 284 --QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ--QERREQQEERREQQL 339 Query: 1022 MDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY 1081 E ++ EQ ++ E + R + +++ RR Q + ++ LR Sbjct: 340 RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399 Query: 1082 TALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKIS 1141 + + + E++++R +E H + +R++ E + + Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459 Query: 1142 ---ELERMVAELKKQ---KSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQ 1195 E ER E +KQ + + EE + + E E R+QQ E Q++R E E ++ Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE----QQLRREQEERR 515 Query: 1196 YRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDH 1255 +R E+E ++ L +QL E E +R E LL + EE + E Sbjct: 516 EQRLKRQ--EEEERLQQRLRSEQQLRREQEERR----EQLLK---REEEKRLEQERREQR 566 Query: 1256 LKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQ-- 1313 LKR+ D ++ + + R KR+ EE L + +K+ E + Q++ E++LK ++ Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626 Query: 1314 ---------KIELEARR--KITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAE 1362 E E RR ++ Q RE L + R L++EH++++ E Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLK----REEEEERLEQRLKREHEEERRE 682 Query: 1363 ELKQQVDELTAANR------------KAEQDMRELTYELNALQLE----KTSSEEKARLL 1406 + + ++ A R ++E D R+ + E + EEK R Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742 Query: 1407 KDKL--DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQ----------LNQTTGKAEE 1454 + +L E R + E +R+D + +++ E GRQ + +AEE Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802 Query: 1455 AMQ----------EASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL 1504 Q E ++ +R + EL+ L E+ +RE + + + Q Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862 Query: 1505 NSQIHSFRDEKELERLQICQRKSDH-------LKEQFEKSHEQLLQNIKAEKENNDKIQR 1557 RD+K +L+ +++ H L+EQ K +QLLQ + E + ++ +R Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK-EQQLLQEEEEELQREEREKR 921 Query: 1558 LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQR---------IQAESENIVLEKQTIQ 1608 +E E+ E L+Q+ E+L R+ E + +R +Q + E ++ E+ + Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981 Query: 1609 QRCEALKIQADGFKDQLRSTNEHL---HKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665 +R E K + +++L+ E L ++ + Q+++R+ + +E + + L+ E ++ Sbjct: 982 RRQEREKKYRE--EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039 Query: 1666 KCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ---QAQVQELNNRLKKVQDE 1722 K Q Q ++E E +E + R Q+++ Q + ++Q+ +L + + E Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099 Query: 1723 LHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSL 1782 + E+ + L QEE + EE K+ + +E + E ++ + Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLR---EEREKRRRQELERQYREEEEVQQEEEQLLRE 1156 Query: 1783 QQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREV 1842 + E R Q ELER QYRE+ + Q E ++ +K E Q RE Sbjct: 1157 EPEKRRRQ-----------ELER---QYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202 Query: 1843 ENL-KQKMDQQIKEHEHQLVL-LQCEIQKKSTAKD----CTFKPDFEM-TVKECQHSGEL 1895 E L +QK Q+ ++ + + L Q E +K++ +D C + + + +++ Q Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262 Query: 1896 SSRNTGHL-----HPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEK 1950 S ++ HL RW Q + E+ Q EQ KE + + + EK+ Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ--KEAKRRDRKSQEEKQL 1320 Query: 1951 SQQCYSEYFSQTSTELQITFD-------ETNPITRLSEIEKIRDQALNN 1992 ++ E + T+ + + E P+ R K R++ L + Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369 Score = 124 bits (311), Expect = 1e-27 Identities = 209/1014 (20%), Positives = 426/1014 (42%), Gaps = 113/1014 (11%) Query: 1058 VKRRRMQSSADLIIQEFMDLRTR-------YTALVTLMTQYIKFAGDSLKRLEEEEIKRC 1110 ++R + DLI+ E +DL + + + + Q +A L+EE+ RC Sbjct: 45 LRRPHDPKTVDLIL-ELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARC 103 Query: 1111 KETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEE-ELPKVREAAE 1169 G S L R++ + + + +LE + ++QK + +E EL + E +E Sbjct: 104 D-----GKESLLQDRRQEE--DQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156 Query: 1170 NELRKQQRNVE--DISLQKIRAESEAKQYRR------------ELETIVREKEAAERELE 1215 + R +QR+ + D L + R E + ++ RR E E E++ REL Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216 Query: 1216 RVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRT--------LEDHLKRKDLSLNDLE 1267 +R+ E + ++ ++ + F+ + E+ R T L++ ++ L + E Sbjct: 217 ELRRKGREEKQQQRRERQDRV-FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275 Query: 1268 QQKNKL-MEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326 +Q KL +ELRR+R EE+ + +++ E+ L +KQ E++ +++++ E + RR E Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRR-EQQLR-RKQEEERREQQEERREQQERR---EQ 330 Query: 1327 QYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELT 1386 Q RE L + R L++E ++++ E+ ++ E + EQ +R Sbjct: 331 QEERREQQL-----RREQEERREQQLRREQEEERREQQLRREQE----EERREQQLRREQ 381 Query: 1387 YELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN 1446 QL + + + L+ + + +L R+ Q + ++ E + Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441 Query: 1447 QTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNS 1506 + + + +E D +KR + E K +L+R+ + R + + + Sbjct: 442 RREQRLKREQEERRDW--LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499 Query: 1507 QIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSN 1566 Q R E++L R Q +R+ LK Q E+ E+L Q +++E++ + + E+L K Sbjct: 500 Q---ERREQQLRREQE-ERREQRLKRQEEE--ERLQQRLRSEQQLRREQEERREQLLKRE 553 Query: 1567 ECAEMLKQKVEE-LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQL 1625 E + +++ E+ L R+ E + + + + E L+++ ++ + LK + +Q Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613 Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLN 1685 + L ++ E+ Q+ +K E++ + Q L E +++ +Q+ ++E L Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR----LKREEEEERLE 669 Query: 1686 AELNASKEEKRRGEQKVQLQQAQVQE-LNNRLKKVQDELHLKTIEEQMTHRKMVLF---- 1740 L EE+RR ++ + +Q Q +E + +R+ K Q +L E + R+ ++ Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL-----ESEADARQSKVYSRPR 724 Query: 1741 QEESGKFKQSAEEFRKKMEKLM----ESKVITENDISGIRLDFVSLQQENSRAQENAKLC 1796 ++E + +Q EE R++ E + E + + R DF Q +++ + Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784 Query: 1797 ----------ETNIKELERQLQQYR-----EQMQQGQHMEANHYQKCQKLEDELIAQKRE 1841 E ++ ERQ ++ R E+ +Q + ++ Q LE+E Q+RE Sbjct: 785 SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844 Query: 1842 VENLKQKMDQQIKEHEH----------QLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQH 1891 Q+ + ++E + Q Q E ++K KP + +++ Q Sbjct: 845 RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ- 903 Query: 1892 SGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEV----QFQPPGAPLE 1947 +L L R R QE Q EE+ + EQ+ +E + Q Sbjct: 904 --QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961 Query: 1948 KEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQD 2001 K+K Q E E + + E+++ +Q L R R Q+ Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015 Score = 115 bits (288), Expect = 6e-25 Identities = 220/1084 (20%), Positives = 465/1084 (42%), Gaps = 121/1084 (11%) Query: 710 QLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE 769 QL KE + ++ +EL + + + + Y E + L+ E++L+R+ R Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ-----LQQEEEQLLREEREKRR 952 Query: 770 RDDLH-----ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824 R + + + E++ L +E E+ + + EE Q LR E Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ----LLREER 1008 Query: 825 NVVLQNMNQVYSMSSTYIDKLKTVNLVL-------KNTQAAEALVKLYETKLCEEEAVIA 877 + Q + D+L+ L + Q E + E EEE ++ Sbjct: 1009 E---KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065 Query: 878 DKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEK 937 ++ +Q+R E + +++ L +E +K + E + +E +L +++ Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER-QCREEEEL-----QQE 1119 Query: 938 ADQLV--ERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP 995 +QL+ ER + +++ + R+ E + + + P Q++E R+ +E Q Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQ 1178 Query: 996 ENSKTLATQLNQ-----QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050 E + L + + ++ E E+++ K Q+Y ++ + ++ + A+ Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRK--QRYRDEDQRSDLKWQWEPEKENAVR 1236 Query: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRC 1110 D+ K K R + L + D +++ L G+ +R E+E +R Sbjct: 1237 DN--KVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL--------GEQQERDREQERRRW 1286 Query: 1111 KETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAA-- 1168 ++ H + L+R++ E + K E ++++ E +++K R +E K RE Sbjct: 1287 QQRDRHFPEEEQLEREEQK--EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL 1344 Query: 1169 -----ENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIE 1223 E LR+Q+R+ +++R + + +++ E E +R +E + L+ +QL + Sbjct: 1345 LQEREEQPLRRQERD-RKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEEQQLRCQ 1402 Query: 1224 AEAKRAAVEENLLNFRNQLEENTFTR-------RTLEDHLKRKDLSLNDLEQQKNKLMEE 1276 E ++ ++ FR EE +R R E ++R++ LE+++ +L +E Sbjct: 1403 -EREQQLRQDRDRKFRE--EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ-QLRQE 1458 Query: 1277 LRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR-RKITEIQYTCRENAL 1335 RK EE+LL+ + E+ +++ K L+E+Q++ + R RK E + +E Sbjct: 1459 RHRKFREEEQLLQ---EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515 Query: 1336 PVCPITQAT--SCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQ 1393 Q R LQ+E ++ E +Q+ + R+ EQ L E Q Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ----LRQEREEQQ 1571 Query: 1394 LEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAE 1453 L + + K RL + K+ R+ + E+ + + ++L RQ Q + E Sbjct: 1572 LSRQERDRKFRLEEQKV---------------RRQEQERKFMEDEQQLRRQEGQQQLRQE 1616 Query: 1454 EAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD 1513 + D + ++ + +L ++ L+ E ++ R E+ ++H + FR+ Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEE-PQLRRQER--EQQLRH--DRDRKFRE 1671 Query: 1514 EKEL----ERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECA 1569 E++L E Q+ +++ D +F + +QL + + K ++ Q +ELE+ Sbjct: 1672 EEQLLQEGEEQQLRRQERDR---KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE 1728 Query: 1570 EMLKQKVEE--LTRQNNETKLMMQ-RIQAESENIVLEKQTIQQRC-EALKIQADGFKDQL 1625 E L+Q+ E+ L RQ K++ + +++ E E L +Q ++ E +++ + + QL Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL 1788 Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK---KEVR 1682 RS E K + EQ Q + EE + Q +++ + +Q + Q + + R Sbjct: 1789 RS-QESDRKFREEEQLRQER----EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDR 1843 Query: 1683 NLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQE 1742 AE + +EK R E++ Q+ + + R +K+++E + +E+ HR++ + Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903 Query: 1743 ESGK 1746 + GK Sbjct: 1904 QEGK 1907 Score = 76.3 bits (186), Expect = 4e-13 Identities = 129/592 (21%), Positives = 252/592 (42%), Gaps = 62/592 (10%) Query: 893 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 952 R E D K + L + Q K + +E +ER+ F +E+ + ER Q + Sbjct: 1355 RQERDRKFRE-EELRHQEQGRKFLEEEQRLRRQERERKF-LKEEQQLRCQEREQQLRQDR 1412 Query: 953 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1012 D + R+ E + + RD ++ + + +RK E + + + + +++ L+ Sbjct: 1413 DRKFREEEQ--QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470 Query: 1013 SEIEMKQ-SKMDECQKYAE---QYSATVKDYELQTMTYRAMVDS----QQKSPVKRRRMQ 1064 E E +Q + + +K+ E Q +D + + R+ +++ + R++ Q Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530 Query: 1065 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAG------------------DSLKRLEEEE 1106 +QE LR + + KF D RLEE++ Sbjct: 1531 RK---FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587 Query: 1107 IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVRE 1166 ++R ++ + L+RQ+ + K E E+++ E ++Q+ +E K E Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647 Query: 1167 AAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEA 1226 E +LR+Q+R Q++R + + K +R E + + +E R ER R+ E + Sbjct: 1648 E-EPQLRRQERE------QQLRHDRDRK-FREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699 Query: 1227 -KRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKN--KLMEELRRKRDN 1283 +R E L QL R+ E+ R++ L +Q+ K++EE + + + Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759 Query: 1284 EEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIEL-EARRKITEIQYTCRENALPVCPITQ 1342 EE+ L+ + E+D F+++ +Q +E+Q++ E+ RK E + +E + Sbjct: 1760 EEQQLR---RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER--------E 1808 Query: 1343 ATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEK 1402 R QQ K + EE + Q++E R+ E+D + E A Q EK+ EE+ Sbjct: 1809 EQQLRP----QQRDGKYRWEEEQLQLEEQEQRLRQ-ERDRQYRAEEQFATQ-EKSRREEQ 1862 Query: 1403 ARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEE 1454 +++ R L+ E R+ Q E+ +Q+ E+ Q + G+ E Sbjct: 1863 ELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914 Score = 33.1 bits (74), Expect = 3.7 Identities = 42/216 (19%), Positives = 88/216 (40%), Gaps = 23/216 (10%) Query: 251 QTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVES 310 Q LK + + L + +Q L E+ + + LL +E +++ +R E ++ Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERR--EQLLKREEEKRLEQERRE-----QRLKR 569 Query: 311 HLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQER 370 E ++ EE + + E ++ LK E+L + E + +L +ER Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629 Query: 371 HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 430 L + E+ ++++ + ER ++++ L + L ++ E + Sbjct: 630 RQQLLKSEEQE---------ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680 Query: 431 SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 466 QE+AE+ E AR I+ + +W W L+ Sbjct: 681 REQELAEE---EQEQARERIK----SRIPKWQWQLE 709 >gi|114155142 nuclear pore complex-associated protein TPR [Homo sapiens] Length = 2363 Score = 159 bits (401), Expect = 5e-38 Identities = 335/1709 (19%), Positives = 684/1709 (40%), Gaps = 218/1709 (12%) Query: 265 SSLLDQNLTEEEINM--KFVQDLLN-WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA 321 +++L Q L E+N K VQ+ L ++ + Q ++D + + VES + + Sbjct: 2 AAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFE----- 56 Query: 322 IEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNF--- 378 IE+ S +E ++E + L+L + ++L++ K Q+R++ F Sbjct: 57 IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116 Query: 379 ---VSRATNELIWLNEKEEEEVAY---DWSERNTNIARKKDYHAELMRELDQKEENIKSV 432 + +LI NE+ +E+ Y D N + EL +LD+ + + SV Sbjct: 117 KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176 Query: 433 QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 492 + ++L E ++T+ +L L + E N+ E Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR-------------EKGNEILELK 223 Query: 493 DYLRNLKDAIQR---KYSCDRSSSIH---KLEDLVQESMEEKEELLQYKSTIANLMGKAK 546 L N K+ + R + + ++S+ H +EDL+ + E KE+ + N + Sbjct: 224 CNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHI 283 Query: 547 TIIQL-KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNE 605 + L K D K++ +A+ + ++ E AN + + + + ++ Sbjct: 284 KLSNLYKSAADDSEAKSNELTRAVEELHKLL------KEAGEANKAIQDHLLEVEQSKDQ 337 Query: 606 AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665 KE ++ R+E++ +N L S K + E+ + Sbjct: 338 M------------EKEMLEKIGRLEKELENANDLL--SATKRKGAILSE---EELAAMSP 380 Query: 666 SNVASIKTMLPGEHQQVLSNLQSRFED--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 723 + A K + PG L N +D LE + ++ D ++ KEV + Sbjct: 381 TAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLD--EIVKEVEAKAPILK 438 Query: 724 ELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQ 783 + ER ++ + ++ + + RL+ D+ +Q + LERD+ + Sbjct: 439 RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQ-SSVLERDNRRMEIQVKDLS 497 Query: 784 EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843 ++++ L L++ G + EE S +SSS V+ Q++ +S I+ Sbjct: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSS--------EVISQHL-----VSYRNIE 544 Query: 844 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN-----IENLISTLKQWRSEVDE 898 +L+ +N + AL +L ET+ EE+ + K +E+ ++ L+Q R Sbjct: 545 ELQQ-----QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQH 599 Query: 899 KRQVFHALEDELQKAKAISDEMF--------KTYKERDLDFDWHKEKADQLVERWQNVHV 950 + Q+ ++ + + + + + + L + Q V V V Sbjct: 600 QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPV 659 Query: 951 QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKM 1010 + + K L+ + Y ++ + KIQ Q E + T L Q Sbjct: 660 IESTEAIEAKAALKQLQEIFENY-------KKEKAENEKIQNEQLEKLQEQVTDLRSQNT 712 Query: 1011 LVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLI 1070 +S +++D K E V+ Y R + +++ Q +I Sbjct: 713 KIS------TQLDFASKRYEMLQDNVEGYR------REITSLHERNQKLTATTQKQEQII 760 Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130 DLR L + ++LK+ E+E+ + E LL Q+ Sbjct: 761 NTMTQDLRGANEKLAVAEVR-----AENLKK--EKEMLKLSEVRLSQQRESLLAEQRGQN 813 Query: 1131 LENSKLTGKISELERMVAELKKQKS----RVEEELPKVREAAENELRKQQRNVEDISLQK 1186 L + L LER E K++ S ++E E+ +++ ENE+ ++ ++ +Q Sbjct: 814 LLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQL 873 Query: 1187 IRAESEAKQYRRELETIVREKEAAERELE-RVRQLTIEAEAKRAAVEENLLNFRNQLEEN 1245 + +R+L+T E L ++L A+ + A ++++L N Q+ Sbjct: 874 LDT-------KRQLDT--------ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918 Query: 1246 TFTRRTLEDHLKRKDLS-----LNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAF 1300 + R ++D+ L E+Q N L E L+ N E+ ++ +E+ L Sbjct: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNK 978 Query: 1301 QKQVAEK-------QLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQ 1353 +KQV E+ +LKE + + + +K+ E++ +E Q RA+ ++ Sbjct: 979 EKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE--------LQDDKRRAIESME 1030 Query: 1354 QEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDET 1413 Q+ ELK+ L++ + ++ ++ + L+ Q + +E+A++ + ++ Sbjct: 1031 QQ-----LSELKK---TLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY 1082 Query: 1414 NNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASD--------LKKI 1465 L ++E QA K ++ + + L +TT KAE + E LK Sbjct: 1083 ERELMLHAADVEAL-QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDE 1141 Query: 1466 KRNYQLELESLNHEKGKLQREVDRIT-RAHAVAEKNIQ---HLNSQIHSFRDEKELERLQ 1521 E L + L ++++++ + A ++ +Q +++ E+ LE L+ Sbjct: 1142 VSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR 1201 Query: 1522 ICQRKSDHLKEQFEKSHEQLL---QNIK-AEKENNDKIQRLNEELEKSNECAEMLKQKVE 1577 +R+ + + +FE + + L Q ++ E+E + LN E EK A+ + Q E Sbjct: 1202 FIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE 1261 Query: 1578 ELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637 + + +M E LE+ Q + + K++ D L+ N L +++ Sbjct: 1262 LMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDIL--PLQEANAELSEKSG 1319 Query: 1638 TEQDFQRKIKCLEEDL----AKSQNLVSEFKQKCDQQNIIIQNTK----KEVRNLNAELN 1689 Q + K LEED+ A++Q+LVS+ K ++ + + K K ++ L E+ Sbjct: 1320 M---LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376 Query: 1690 ASKEEKRRGEQKVQLQQAQVQELNNRLKKV-------QDELHLKTIEEQMTHRKMVLFQE 1742 K E R + Q +Q L L KV Q +L K I+ Q + + ++ Sbjct: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK 1436 Query: 1743 ESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKE 1802 ++K EE + + +K+ME+ + D + QE +E ET K Sbjct: 1437 IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV----QEMQELKETLNQAETKSKS 1492 Query: 1803 LERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVEN---LKQKMDQQIKEHEHQ 1859 LE Q++ ++ + + + N ++ +L+ EL ++++++ ++++ QQI E E + Sbjct: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552 Query: 1860 ----LVLLQCEIQKKSTAKDCTFKPDFEM 1884 +V + +I + KD K + E+ Sbjct: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEEL 1581 Score = 124 bits (312), Expect = 9e-28 Identities = 307/1618 (18%), Positives = 645/1618 (39%), Gaps = 254/1618 (15%) Query: 678 EHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQ--- 734 + Q + L+ R E F +S E Q F ++EK ++ + QE L + RE Q Sbjct: 31 DQQSEIDGLKGRHEKFKVES-EQQYF------EIEKRLS----HSQERLVNETRECQSLR 79 Query: 735 -EESVYNLYISEVRNIRLRLENCEDRLIR-QIRTPLERDDLH-ESVFRITEQEKLKKELE 791 E N + + LE +DR I Q + +++L E I E+L +ELE Sbjct: 80 LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELE 139 Query: 792 RLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLV 851 L +D+ + K +E T + EL + L + Q +S Y +K Sbjct: 140 YLTEDVKRLNEKLKES----------NTTKGELQLKLDEL-QASDVSVKYREKRLEQEKE 188 Query: 852 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQ 911 L ++Q +L +TK E A+ +K N + + + ++ K++ LE+++ Sbjct: 189 LLHSQNTWLNTEL-KTKTDELLALGREKGN------EILELKCNLENKKEEVSRLEEQMN 241 Query: 912 KAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN---VHVQIDNRL------------ 956 K ++ + K ++ KE+ + E++ N H+++ N Sbjct: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301 Query: 957 ---RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013 R +E + K LK + + D + +VE ++ ++++ E L +L L+S Sbjct: 302 ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS 361 Query: 1014 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1073 + K A + + EL M+ A ++ I++ Sbjct: 362 ATKRK--------------GAILSEEELAAMSPTAAAVAK----------------IVKP 391 Query: 1074 FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKE--TSEHGAYSDLLQRQKATVL 1131 M L Y A V Q + L++LE + I + + E A + +L+RQ+ Sbjct: 392 GMKLTELYNAYVETQDQLL------LEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445 Query: 1132 ENSKLTGKIS-ELERMVAELKKQKSRVEEELPKVREAA---ENELRKQQRNVEDISLQKI 1187 K +S +LE+ + E++ R++E+ K + + E + R+ + V+D+S Q Sbjct: 446 RAQKAVASLSVKLEQAMKEIQ----RLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIR 501 Query: 1188 RAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTF 1247 E ++ R ++R++E + ++ ++ + ++L+++RN +EE Sbjct: 502 VLLMELEEARGN--HVIRDEEVSSADISSSSEV----------ISQHLVSYRN-IEE--- 545 Query: 1248 TRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE-----EELLKLIKQMEKDLAFQK 1302 L+ +R ++L +L + + + +E + E E L ++Q+ K Q Sbjct: 546 ----LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601 Query: 1303 QVAEKQLKEKQK----------------------IELEARRKITEIQYTCRENA-LPVCP 1339 Q+ + ++++ + L + K T A +PV Sbjct: 602 QLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIE 661 Query: 1340 ITQATSCRAVTGLQQE----HDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLE 1395 T+A +A QE + K+KAE K Q ++L K ++ + +L + + + Sbjct: 662 STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL----EKLQEQVTDLRSQNTKISTQ 717 Query: 1396 KTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEA 1455 + ++ +L+D ++ + L ++ + Q + + + L K A Sbjct: 718 LDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777 Query: 1456 MQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEK 1515 A +LKK K +L L+ ++ L E R + N+Q + + E Sbjct: 778 EVRAENLKKEKEMLKLSEVRLSQQRESLLAE----QRGQNLLLTNLQTIQGILERSETET 833 Query: 1516 ELE---RLQICQRKSDHLKEQFEKSHEQ---LLQNIKAEKENNDKIQRLNEELEKSNECA 1569 + +++ + + HLK++ E EQ L +N+ + D ++L+ E Sbjct: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL--DTKRQLDTETNLHLNTK 891 Query: 1570 EMLKQKVEEL-TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRST 1628 E+LK +E+ T + + + + +Q S+ + + ++ + L Q ++Q+ Sbjct: 892 ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDL 951 Query: 1629 NEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCD---QQNIIIQNT-KKEVRNL 1684 E L T + +Q + LEE L K + + E ++ + +++ Q +K++ + Sbjct: 952 KERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEV 1011 Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744 E +++KRR ++ + Q+ EL L VQ+E ++E + L E+ Sbjct: 1012 EKEKQELQDDKRRA---IESMEQQLSELKKTLSSVQNE-----VQEALQRASTALSNEQ- 1062 Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKL---CETNIK 1801 Q+ + +++ + +E++ E ++ D +LQ + + A + E + Sbjct: 1063 ----QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQ 1118 Query: 1802 ELERQLQQYREQMQQGQHMEANHYQKC------------------QKLEDELIAQKREVE 1843 + E QL + + ++ + M + KC +KL D+++A +E Sbjct: 1119 KAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGV 1178 Query: 1844 N--LKQKMDQQIKEHEHQLVLLQCEIQKKSTAK---------DCTFKPDFEMTVKECQHS 1892 L + ++ K E L +L+ ++K A+ ++ E+ +E Q Sbjct: 1179 QGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQEL 1238 Query: 1893 GELSSRNTGHLHPTPRS-----PLLRWTQEPQPLEE-----KWQHRVVEQIPKEVQFQPP 1942 + + + T ++ L++ T+ + E + + +EQ +++Q + Sbjct: 1239 QDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVR 1298 Query: 1943 GAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDN 2002 L+ Q+ +E S+ S LQ +L E + R +A N V Q + Sbjct: 1299 KLELDILPLQEANAE-LSEKSGMLQAE-------KKLLEEDVKRWKARNQHL--VSQQKD 1348 Query: 2003 ACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFL 2062 E K+L+ E+ + + E+ LK E + + + LK+ D Sbjct: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAE---IARSNASLTNNQNLIQSLKE-DLN 1404 Query: 2063 KKGLEPETFQNFDGDHACSVRDD-----EFKFQGLRHTVTARQLVEAKLLDMRTIEQL-- 2115 K E ET Q +++ + K G R+ +L + M T Q Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464 Query: 2116 -----RLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVAL 2168 + ++ ++E+++TLN+ TK+ S+ +E+ ++ +S R + ++ V L Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLES-QVENLQKTLSEKETEARNLQEQTVQL 1521 Score = 99.4 bits (246), Expect = 4e-20 Identities = 236/1185 (19%), Positives = 471/1185 (39%), Gaps = 186/1185 (15%) Query: 967 KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ 1026 K+ D +D + E + + ++ E K L+ + Q+ LV+E QS E + Sbjct: 27 KFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS---HSQERLVNETRECQSLRLELE 83 Query: 1027 KYAEQYSA-TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085 K Q A T K+ EL+ R + Q + K DLI R + + Sbjct: 84 KLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLI-----RTNERLSQEL 138 Query: 1086 TLMTQYIKFAGDSLK-----------------------RLEEEEIKRCKET--SEHGAYS 1120 +T+ +K + LK + E+ +++ KE S++ + Sbjct: 139 EYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLN 198 Query: 1121 DLLQRQKATVLENSKLTG-KISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNV 1179 L+ + +L + G +I EL+ + K++ SR+EE++ ++ + E+ Q++V Sbjct: 199 TELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH----LQKHV 254 Query: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERV-RQLTIEAEAKRAAVEENLLNF 1238 ED+ L K++ EAK+ + +E + A +L + + ++EAK + + Sbjct: 255 EDL-LTKLK---EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEEL 310 Query: 1239 RNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQ----- 1293 L+E + ++DHL + S + +E++ + + L ++ +N +LL K+ Sbjct: 311 HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAIL 370 Query: 1294 MEKDLAFQKQVAEKQLK---------------------------EKQKI---------EL 1317 E++LA A K E ++I E+ Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430 Query: 1318 EARRKITEIQ---YTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAA 1374 EA+ I + Q Y + A+ + + + + LQ++ DK +Q L Sbjct: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDK-----ANKQSSVLERD 485 Query: 1375 NRKAEQDMRELTYELNAL--QLEKTSSEEKARLLKDKLDETNNTLRCLKLEL------ER 1426 NR+ E +++L+ ++ L +LE+ R + + +++ + L E Sbjct: 486 NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545 Query: 1427 KDQAEKGYSQQLRELG----RQLNQTTG--------KAEEAMQEASDLKKIKRNYQLELE 1474 Q + LRELG R+ +TT K E A+ E L+K +++ ++ Sbjct: 546 LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605 Query: 1475 SLNHEKGKLQREVDRIT------RAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528 S+ ++ + + + T A ++ + ++ + + + + + + Sbjct: 606 SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665 Query: 1529 HLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKL 1588 + K +++ +N K EK N+KIQ NE+LEK L+++V +L QN TK+ Sbjct: 666 IEAKAALKQLQEIFENYKKEKAENEKIQ--NEQLEK-------LQEQVTDLRSQN--TKI 714 Query: 1589 MMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKC 1648 Q A +R E L+ +G++ ++ S +E K T T Q ++ I Sbjct: 715 STQLDFA------------SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762 Query: 1649 LEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLN-AELNASKEEKRRGEQKVQLQQA 1707 + +DL + +K + +N KKE L +E+ S++ E + Q+ Sbjct: 763 MTQDLRGA-------NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR----ESLLAEQRG 811 Query: 1708 QVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVI 1767 Q L N L+ +Q +E T K L + K + +KK+E +E + Sbjct: 812 QNLLLTN-LQTIQG-----ILERSETETKQRL-SSQIEKLEHEISHLKKKLENEVEQRHT 864 Query: 1768 TENDISGIRLDFV-SLQQENS---RAQENAKLCETNIKELERQLQQYREQMQQGQHMEAN 1823 ++ LD L E + +E K + I L++ L Q+ Sbjct: 865 LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTG 924 Query: 1824 HYQKCQKLE-DELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882 Q K + D+L++Q R+ E + +++K + Q + T+ + + + Sbjct: 925 KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980 Query: 1883 EMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPP 1942 ++T +E + + E+ + + L+ +E Q L++ + R +E + +++ Sbjct: 981 QVT-EEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDD-KRRAIESMEQQL----- 1033 Query: 1943 GAPLEKEKS--QQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQ 2000 + L+K S Q E + ST L +E E KI +A N + Sbjct: 1034 -SELKKTLSSVQNEVQEALQRASTALS---NEQQARRDCQEQAKIAVEAQNKYERELML- 1088 Query: 2001 DNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEW 2045 +A ++E ++ +++K H E TT K E + W Sbjct: 1089 -HAADVEALQAAKE-QVSKMASVRQHLEETTQKAESQLLECKASW 1131 Score = 81.6 bits (200), Expect = 9e-15 Identities = 267/1439 (18%), Positives = 562/1439 (39%), Gaps = 167/1439 (11%) Query: 110 ECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQT 169 E ++ H+++V+ K ++++++ +L E+ + S+ KG IL+ E+ Sbjct: 319 EANKAIQDHLLEVE---QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEEL 375 Query: 170 KLM---ISGITQSLNSGFAQT-LHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTS-RLTPS 224 M + + + + G T L+ + Q L L + + L + Sbjct: 376 AAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAP 435 Query: 225 VTPAYTPGFPSG--LVPNFSSGVEPNSLQTLKLMQ-IRKPLLKSSLLDQNLTEEEINMKF 281 + + V + S +E + +L + K +SS+L+++ EI +K Sbjct: 436 ILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKD 495 Query: 282 VQD----LLNWVDEMQ---VQLDRTEWGSDLPSVESHLENHKNVHRAIEEFES------- 327 + LL ++E + V D +D+ S + H +R IEE + Sbjct: 496 LSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLV 555 Query: 328 SLKE--------------AKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLD 373 +L+E +KI+E+Q+ LT E+L + +L+++ Q D Sbjct: 556 ALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR---D 612 Query: 374 TLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL----MRELDQKEENI 429 +S+ T I L+ ++V+ + + + ++ A + E + + + Sbjct: 613 MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL 672 Query: 430 KSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAK 489 K +QEI E E +Q Q + + + + + +E D Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732 Query: 490 EATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ---ESMEEKEELLQYKSTIANLMGKAK 546 E Y R + +R +++ K E ++ + + E L A + K K Sbjct: 733 EG--YRREITSLHERNQKL--TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788 Query: 547 TIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEA 606 +++L ++ + + + + +T + + +L + K ++ S Sbjct: 789 EMLKLSEVRLSQQRESLLAEQR---GQNLLLTNLQTIQGILERSETETKQRLSS------ 839 Query: 607 MVPSVCFTVPPPNKEAVDLANRIEQQY---QNVLTLWHESHINMKSVVSWHYLINEIDRI 663 + + + K+ L N +EQ++ +N+ ++ + + + H E+ + Sbjct: 840 QIEKLEHEISHLKKK---LENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896 Query: 664 RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQ 723 +A++K L QV S R ++E S + Q E++VN K+ Sbjct: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE--- 953 Query: 724 ELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQ 783 L S EQ Y + V ++ L N E ++ ++R +E L ES T+ Sbjct: 954 RLKTSTSNVEQ-------YQAMVTSLEESL-NKEKQVTEEVRKNIEVR-LKESAEFQTQL 1004 Query: 784 EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843 EK E+E+ K +L + E Q + L+ L+ V + + +ST Sbjct: 1005 EKKLMEVEKEKQELQDDKRRAIESMEQQLSE-----LKKTLSSVQNEVQEALQRAST--- 1056 Query: 844 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIA--DKNNIENL-------ISTLKQWRS 894 L N Q A + C+E+A IA +N E + L+ + Sbjct: 1057 -------ALSNEQQAR--------RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKE 1101 Query: 895 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954 +V + V LE+ QKA++ E +++ER+ K++ + V R +++ Q N Sbjct: 1102 QVSKMASVRQHLEETTQKAESQLLECKASWEERERML---KDEVSKCVCRCEDLEKQ--N 1156 Query: 955 RLRDLEGIGKSLKYYRDTYHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQKMLV 1012 RL D L D + E Q + + E K+ L + + Sbjct: 1157 RL------------LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204 Query: 1013 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1072 E E+ +++ + Q + +Y V+ E R + + Q +R ++Q +A + Q Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLE------RELQELQDSLNAEREKVQVTAKTMAQ 1258 Query: 1073 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLE 1132 ++ T V + T K + +RLE++ + + D+L Q+A E Sbjct: 1259 HEELMKKTETMNVVMETN--KMLREEKERLEQD--LQQMQAKVRKLELDILPLQEANA-E 1313 Query: 1133 NSKLTGKISELERMVAE-LKKQKSRVEEELPKVREAAENELRK--QQRNVEDISLQKI-- 1187 S+ +G + ++++ E +K+ K+R + + + ++ E RK ++ V +Q++ Sbjct: 1314 LSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTE 1373 Query: 1188 ---RAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEE 1244 R ++E + L ++ + +L +VR E E + ++ +++ + +++ Sbjct: 1374 EIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT---EKETIQKDLDAKIIDIQEKVKT 1430 Query: 1245 NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQME--KDLAFQK 1302 T ++ +R +L+ Q++K+ME + + +E +++M+ K+ Q Sbjct: 1431 ITQVKKIG----RRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486 Query: 1303 QVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAE 1362 + K L+ ++E +K + T N Q+ R LQ ++ E Sbjct: 1487 ETKSKSLES----QVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE--E 1540 Query: 1363 ELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKL 1422 +L+QQ+ E RKA + L ++ + T E+ + LD+ + L Sbjct: 1541 QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT 1600 Query: 1423 ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKG 1481 L K Q E S+ REL + + +E + ++ + + +R L+ + E+G Sbjct: 1601 AL--KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657 >gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] Length = 1684 Score = 158 bits (400), Expect = 6e-38 Identities = 303/1548 (19%), Positives = 643/1548 (41%), Gaps = 210/1548 (13%) Query: 408 IARKKDYHAELMRELDQKEEN---------IKSVQEIAEQLLLENHPARLTIEAYRAAMQ 458 I + K EL +E+++ IK++ E + LLLE E + + Sbjct: 41 IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEK------AETEQQCLS 94 Query: 459 TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCDRSSSIH 515 + I + + K A+ E + NLK+ A++ KYS D+++ Sbjct: 95 LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQK 154 Query: 516 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI 575 +LE+ + +E E+L ++ N+ + I +++P + L + A D ++ Sbjct: 155 QLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKE 214 Query: 576 EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQN 635 +T ++ + AN+ H K I+ E + +E +L +IE + Sbjct: 215 TVTQLQN--IIEANSQHYQ--KNINSLQEELLQLKAIH-----QEEVKELMCQIEASAKE 265 Query: 636 VLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLE 695 HE+ IN +NE+ + + + +++ L NL+ + + Sbjct: 266 -----HEAEINK---------LNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQ 311 Query: 696 DSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE- 754 D+Q + + T +E+ VN ++ ++ LK E + S+ ++ + N++L+LE Sbjct: 312 DNQICSILL-QENTFVEQVVNEKVKHLEDTLKEL---ESQHSILKDEVTYMNNLKLKLEM 367 Query: 755 ---NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKE----LERLKDDLGTITNKCEEF 807 + +D ER+DL F+I E K+E +E+LK +L + Sbjct: 368 DAQHIKDEFFH------EREDLE---FKINELLLAKEEQGCVIEKLKSELAGLN------ 412 Query: 808 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYET 867 + V Q+ +V S+ + ++ +N + E L ++E Sbjct: 413 -------------KQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEI 459 Query: 868 KLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKER 927 + +E+ ENL ++ + R++ L+ EL ++ + F++ K+ Sbjct: 460 QGLKEQC--------ENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQ- 510 Query: 928 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987 ++A + E Q + + LE + + L+ + + + ++E T Sbjct: 511 --------QQASDVHELQQKLRTAFTEKDALLETVNR-LQGENEKLLSQQELVPELENTI 561 Query: 988 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1047 + +Q E + L+Q+ ++ E+E K++ + + + +K+ + + Sbjct: 562 KNLQ----EKNGVYLLSLSQRDTMLKELE---GKINSLTEEKDDFINKLKNSHEEMDNFH 614 Query: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE--E 1105 + +++ ++ + + IQ +L + L + + +K + ++LE+ Sbjct: 615 KKCEREERLILE---LGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 671 Query: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRV--EEELPK 1163 ++K E E L K+ EN+KL+ + +L R + QK V +E + + Sbjct: 672 QMKVLSEDKE-----VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQ 726 Query: 1164 VREAAENELRKQ---QRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL 1220 + + + + +Q + +E+ +QK+ +++ + +E+ + V E ++ E+++ V Q Sbjct: 727 LEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSE-DSEEKDVVNVLQA 785 Query: 1221 TIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLK-RKDLSLNDLEQQKNKLMEELRR 1279 E+ AK + E N Q +E LE +K ++ S+ E+ K+ L + + Sbjct: 786 VGESLAK---INEEKCNLAFQRDEKVL---ELEKEIKCLQEESVVQCEELKSLLRDYEQE 839 Query: 1280 K---RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRE---- 1332 K R EE+ + ++ DL K EK E Q + ++ + E+ TC + Sbjct: 840 KVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQ----VEEVSQTCSKSEIH 895 Query: 1333 NALPVCPITQATSCRAVTGLQQEHDKQKAEE---LKQQVDELTAANRKAEQDMRELTYEL 1389 N C I + + + + L+Q+ + + E LK + + + ++EL ++ Sbjct: 896 NEKEKCFIKEHENLKPL--LEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKI 953 Query: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTT 1449 LEK E++ ++ K KL K EL+ + + ++L L + +Q + Sbjct: 954 E--NLEKECKEKEEKINKIKLVAVK-----AKKELDSSRKETQTVKEELESLRSEKDQLS 1006 Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEK---GKLQREVDRITRAHAVAEKNIQHLNS 1506 + +Q A K + Y+ + E L+ EK + ++ +TR + + +NS Sbjct: 1007 ASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINS 1066 Query: 1507 QIHSFRDEKELERLQICQRKSDHLKEQ-FEKSHEQLLQNIKAEKENNDKIQRLNEELEKS 1565 +E L R++ Q + L+ Q E + + + + E E K Q++ E Sbjct: 1067 D-----NEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTV 1121 Query: 1566 NECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQL 1625 NE +EEL Q + K +Q+ E E L K+ QQ + ++ ++ + Sbjct: 1122 NE--------LEELQVQLQKEKKQLQKTMQELE---LVKKDAQQ-TTLMNMEIADYERLM 1169 Query: 1626 RSTNEHLHKQTKTEQDFQRKIK-------CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK 1678 + N+ L + +D +++IK L+E++ Q+ V ++++K + ++ TK Sbjct: 1170 KELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTK 1229 Query: 1679 KEVRNLNAE------LNAS-KEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQ 1731 KE+ + L AS K E +Q+V++ + Q+ E+ + K+ + HLKT EQ Sbjct: 1230 KELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHE--HLKTSAEQ 1287 Query: 1732 MTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQEN-SRAQ 1790 R + +Q+ + +A + + K ++ V +E + +R+ V QQ+N S +Q Sbjct: 1288 -HQRTLSAYQQ-----RVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ 1341 Query: 1791 ENAKLCETNIKELERQLQQYREQMQQGQH---MEANHYQKCQKLEDELIAQKREVENLKQ 1847 + + + LE + Q + ++Q Q+ + + Q Q D L+ + Sbjct: 1342 AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLER-------HN 1394 Query: 1848 KMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGEL 1895 KM Q+ E +L C IQ +++ K + TV + E+ Sbjct: 1395 KMLQETVSKEAELREKLCSIQ----SENMMMKSEHTQTVSQLTSQNEV 1438 Score = 153 bits (386), Expect = 2e-36 Identities = 280/1448 (19%), Positives = 614/1448 (42%), Gaps = 201/1448 (13%) Query: 680 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739 +Q + + ++ D ++ ++S + +I L+ E+ + Y E + +++ +E Sbjct: 103 KQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNT 162 Query: 740 NLYISEVRNIRLRLENCEDRLIRQIRTPLE--RDDLHESVFRITEQEKLKKELERLKDDL 797 L +SE +L+ +N + +++++ +E R E + + Q++L + K+ + Sbjct: 163 QLELSE----QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYL--QKQLDATTDEKKETV 216 Query: 798 GTITNKCEEFFSQAAASSSVPTLRSEL--------NVVLQNMNQVYSMSSTY---IDKLK 846 + N E + ++ +L+ EL V + M Q+ + + + I+KL Sbjct: 217 TQLQNIIEA--NSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLN 274 Query: 847 TV--NLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDE--KRQV 902 + NLV + + + + K YE +L ++ N + S L Q + V++ +V Sbjct: 275 ELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334 Query: 903 FHALEDELQK-------------------------AKAISDEMFKTYKERDLDFDWHKEK 937 H LED L++ A+ I DE F ++ DL+F K Sbjct: 335 KH-LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFF--HEREDLEF-----K 386 Query: 938 ADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPEN 997 ++L+ + I+ +L G+ K Y + ++ ++V++ + + Q+ E Sbjct: 387 INELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN------REVQSLKEQHQKEISEL 440 Query: 998 SKTLATQLNQQKM-LVSEIEMKQSKMDECQKYAEQYSATVKDYE--------LQTMTYRA 1048 ++T + ++K+ L+ EI Q ++C+ ++ + +YE LQT + Sbjct: 441 NETFLSDSEKEKLTLMFEI---QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGES 497 Query: 1049 MVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEI- 1107 Q+ +++ S + Q+ LRT +T L+ + G++ K L ++E+ Sbjct: 498 AGKISQEFESMKQQQASDVHELQQK---LRTAFTEKDALLETVNRLQGENEKLLSQQELV 554 Query: 1108 ----KRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPK 1163 K E L Q+ T+L+ +L GKI+ L + + EE+ Sbjct: 555 PELENTIKNLQEKNGVYLLSLSQRDTMLK--ELEGKINSLTEEKDDFINKLKNSHEEMDN 612 Query: 1164 VREAAENELR---KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVR-Q 1219 + E E R + + VE E + + LE ++EK+ +++LE++ Q Sbjct: 613 FHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ 672 Query: 1220 LTIEAEAKR--AAVEENLLNFRNQLE-ENTFTRRTLEDHLKRK-DLSLNDLEQQKNKLME 1275 + + +E K +A ++L N+L E R LE L +K D+ L + Q K ++ Sbjct: 673 MKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQ 732 Query: 1276 ELRRKRDNEEELLK---------------LIKQM---------EKDLAFQKQVAEKQL-- 1309 + ++DN +LL+ +K+M EKD+ Q + L Sbjct: 733 LMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792 Query: 1310 --KEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQ 1367 +EK + + K+ E+ E + C + L ++++++K L+++ Sbjct: 793 INEEKCNLAFQRDEKVLEL-----EKEIKCLQEESVVQCEELKSLLRDYEQEKVL-LRKE 846 Query: 1368 VDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELER- 1426 ++E+ + + D+ E+ NA EKT E + L++ ++E + T C K E+ Sbjct: 847 LEEIQSEKEALQSDLLEMK---NAN--EKTRLENQNLLIQ--VEEVSQT--CSKSEIHNE 897 Query: 1427 KDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK---------RNYQLELESLN 1477 K++ + L+ L Q +AE + + S K + + ++E+L Sbjct: 898 KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957 Query: 1478 HEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKS 1537 E + + ++++I A+K + + + ++E E R + K+Q S Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE---------KDQLSAS 1008 Query: 1538 HEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597 L+Q ++ K + ++ +E+L+ E A + ++E+LTRQ + L + I +++ Sbjct: 1009 MRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDN 1068 Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657 E+++ +T+Q + L++Q +++ + K+ + E+ Q+ E+ + + Sbjct: 1069 EDLLARIETLQSNAKLLEVQI----LEVQRAKAMVDKELEAEK-LQK-----EQKIKEHA 1118 Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRG---EQKVQLQQAQVQELNN 1714 V+E ++ + +Q KK+++ EL K++ ++ ++ + ++ELN Sbjct: 1119 TTVNEL----EELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQ 1174 Query: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISG 1774 +L +++ E ++ +K QEE + S +++ +K K+ + V T+ +++ Sbjct: 1175 KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234 Query: 1775 IR-------LDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQM----QQGQHMEAN 1823 + + SL+ E +Q+ ++ + + E+ + + E + +Q Q + Sbjct: 1235 SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSA 1294 Query: 1824 HYQKCQKLEDELIAQKREVENLKQKMDQ-QIKEHEHQLVLLQCEIQKKSTAKDCTFKPD- 1881 + Q+ L++E A K E + + + +++ H VL Q + + S A+ K + Sbjct: 1295 YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHN---VLKQQKNKSMSQAETEGAKQER 1351 Query: 1882 --FEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQF 1939 EM + + + + S N S L E L E+ + E + KE + Sbjct: 1352 EHLEMLIDQLKIKLQDSQNNL----QINVSELQTLQSEHDTLLERHNKMLQETVSKEAEL 1407 Query: 1940 QPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRY 1999 + ++ E + SE+ T T Q+T N + R S +++R + + Sbjct: 1408 REKLCSIQSE-NMMMKSEH---TQTVSQLT--SQNEVLRNSFRDQVRHLQEEHRKTVETL 1461 Query: 2000 QDNACEME 2007 Q +ME Sbjct: 1462 QQQLSKME 1469 Score = 116 bits (291), Expect = 3e-25 Identities = 206/1034 (19%), Positives = 442/1034 (42%), Gaps = 146/1034 (14%) Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVE 1180 DL++ K ++ K + +ELE+ + EL+ + V E + +A L Sbjct: 29 DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKP--VTEGTGDIIKALTERLDALLLEKA 86 Query: 1181 DISLQKIRAESEAKQYRRELETIVREKEAAERELER--------VRQLTIEAEAKRAAVE 1232 + Q + + E + ++E+E V + A +ELE+ + L E A R+ Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146 Query: 1233 ENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDN-EEELLKLI 1291 E+ N + QLEE T+ L + LK + N+ E KL EE+ + R EE++L L Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQ----NNSEDNVKKLQEEIEKIRPGFEEQILYLQ 202 Query: 1292 KQME------KDLAFQKQ----------------VAEKQLKEKQKIELEARRKITEIQYT 1329 KQ++ K+ Q Q + E+ L+ K + E + + +I+ + Sbjct: 203 KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262 Query: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQD-------M 1382 +E+ + + + E + QK E +++ L A A QD + Sbjct: 263 AKEHEAEINKLNELKENLVKQCEASEKNIQKKYEC--ELENLRKATSNANQDNQICSILL 320 Query: 1383 RELTYELNAL-----QLEKTSSEEKAR--LLKDKLDETNNTLRCLKLELERKDQAEKG-Y 1434 +E T+ + LE T E +++ +LKD++ NN LKL+LE Q K + Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN----LKLKLEMDAQHIKDEF 376 Query: 1435 SQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLN----HEKGKLQREVDRI 1490 + +L ++N+ EE + ++K+K EL LN + + REV + Sbjct: 377 FHEREDLEFKINELLLAKEE---QGCVIEKLKS----ELAGLNKQFCYTVEQHNREVQSL 429 Query: 1491 TRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE---KSHEQLLQNIKA 1547 H +K I LN +F + E E+L + + LKEQ E + ++ + N ++ Sbjct: 430 KEQH---QKEISELN---ETFLSDSEKEKLTL-MFEIQGLKEQCENLQQEKQEAILNYES 482 Query: 1548 EKENNDKIQ--------RLNEELE--KSNECAEM--LKQKVEELTRQNNETKLMMQRIQA 1595 +E + +Q ++++E E K + +++ L+QK+ + + + R+Q Sbjct: 483 LREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG 542 Query: 1596 ESENIVLEKQTIQQRCEALK----------IQADGFKDQLRSTNEHLHKQTKTEQDFQRK 1645 E+E ++ +++ + + +K + L+ ++ T+ + DF K Sbjct: 543 ENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINK 602 Query: 1646 IKCLEEDL-------AKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRG 1698 +K E++ + + L+ E +K +Q +++V L L + +EK + Sbjct: 603 LKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQN 662 Query: 1699 EQKVQLQQAQVQELNN-------RLKKVQDELHLKTIEEQMTHRKMVLF--QEESGKFKQ 1749 +QK++ Q++ L+ +K + +E + + E++ R + +F Q+E K+ Sbjct: 663 DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKE 722 Query: 1750 SAEEFRKKMEKLMESK----VITENDISGIRLDFVSLQQENSRAQENAKLCE-TNIKELE 1804 + KK++ ++E + + EN+ ++ FV Q + +++ E + K++ Sbjct: 723 HITQLEKKLQLMVEEQDNLNKLLENE--QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780 Query: 1805 RQLQQYREQMQQGQHMEAN----HYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860 LQ E + + + N +K +LE E+ + E +++ ++++E + Sbjct: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840 Query: 1861 VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP 1920 VLL+ E+++ + K+ EM K L ++N L++ + Q Sbjct: 841 VLLRKELEEIQSEKEALQSDLLEM--KNANEKTRLENQNL----------LIQVEEVSQT 888 Query: 1921 LEEKWQHRVVEQ--IPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITR 1978 + H E+ I + +P LE+++ + +E + + + +P++ Sbjct: 889 CSKSEIHNEKEKCFIKEHENLKP---LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSS 945 Query: 1979 LSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNP 2038 + E+E+ + + L + N ++ VK L+ ++ + + E+ +L+ EK+ Sbjct: 946 VKELEE-KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQ 1004 Query: 2039 VPSAEEWMLEGCRA 2052 + ++ +++G + Sbjct: 1005 LSASMRDLIQGAES 1018 Score = 32.3 bits (72), Expect = 6.4 Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 9/97 (9%) Query: 289 VDEMQVQLDRTEWG-----SDLPSVESH----LENHKNVHRAIEEFESSLKEAKISEIQM 339 +D+++++L ++ S+L +++S LE H + + E+ L+E S Sbjct: 1358 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1417 Query: 340 TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLH 376 +K + + + +L SQ L N+ R+Q RHL H Sbjct: 1418 NMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEH 1454 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 155 bits (391), Expect = 7e-37 Identities = 208/1036 (20%), Positives = 444/1036 (42%), Gaps = 102/1036 (9%) Query: 895 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954 +V + + A EDELQK K ++KA+ ++ + H Q+ Sbjct: 846 QVTRQEEEMQAKEDELQKTKE------------------RQQKAENELKELEQKHSQLTE 887 Query: 955 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014 L+ + L+ + Y ++ ++ +++++E E L + ++ + L +E Sbjct: 888 EKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 944 Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV----KRRRMQSSADLI 1070 + +M + ++ E+ A + +L+ +T A + + + + ++ L+ Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004 Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130 + DL T K + E E++ KE L ++ + Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-- 1062 Query: 1131 LENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-A 1189 + S +I++L+ +AELK Q ++ EEEL ++E+ ++ +L+KIR Sbjct: 1063 -DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-----ALKKIREL 1116 Query: 1190 ESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE------ 1243 E + +L++ E+ A + ++ R L E EA + +E+ L + Q E Sbjct: 1117 EGHISDLQEDLDS---ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173 Query: 1244 -ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEEL-------RRKRDNEEELLKLIKQME 1295 E T ++ L++ + + + ++ Q+ + +EEL +R + N ++ + +++ Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233 Query: 1296 KDLAFQKQV--AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ-----ATSCRA 1348 DLA + +V KQ E +K +LEA ++ E+Q C + + + Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEA--QVQELQSKCSDGERARAELNDKVHKLQNEVES 1291 Query: 1349 VTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408 VTG+ E + KA +L + V L++ + ++ ++E T + + + EE+ L+D Sbjct: 1292 VTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350 Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRN 1468 +LDE E+E K E+ + L QL+ + K ++ L++ K+ Sbjct: 1351 QLDE----------EMEAKQNLER----HISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396 Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528 +Q E+E+L + + D++ + ++ + L + + R + + L+ QRK D Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFD 1454 Query: 1529 H-LKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587 L E+ S + + +AE E +K + L + E L+ K EEL R N K Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARALEEALEAK-EELERTNKMLK 1510 Query: 1588 LMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIK 1647 M+ + + +++ +++ AL+ Q + K QL E L + + +D + +++ Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLE 1566 Query: 1648 CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQA 1707 Q L +F++ D Q QN +K R L +L+ + E ++ L A Sbjct: 1567 ------VNMQALKGQFER--DLQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAA 1617 Query: 1708 QVQELNNRLK--KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESK 1765 ++L LK ++Q + +K EE + +++ Q + F++ E+ R +++ + Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRDEIFATA 1675 Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825 E + D + LQ++ + A+ K + +EL +L Q + Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735 Query: 1826 QKCQKLEDELIAQKREVENLK---QKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882 + +LE+EL ++ +E + +K QQ ++ ++L + QK +A+ + + Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795 Query: 1883 EMTVKECQHSGELSSR 1898 E+ K + G + S+ Sbjct: 1796 ELRSKLHEMEGAVKSK 1811 Score = 146 bits (368), Expect = 3e-34 Identities = 214/1136 (18%), Positives = 488/1136 (42%), Gaps = 124/1136 (10%) Query: 769 ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF-SQAAASSSVPTLRSELNVV 827 + D+L ++ R + E KELE+ L N +E ++ + +R L Sbjct: 857 KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916 Query: 828 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 887 Q + ++ +++ + L+ + A L + EEE K +E + + Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976 Query: 888 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 947 K +++++ V ++L K + + +E + + + +L + ++ Sbjct: 977 EAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034 Query: 948 VHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006 + +++ RL+ E + L K R D+ +Q+ Q +I E L QL Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLA 1086 Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066 +++ E++ +++D+ + A++ +A K EL+ D + + + + Sbjct: 1087 KKE---EELQAALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141 Query: 1067 ADLIIQEFMDLRTRYT-ALVTLMTQYIKFAGDSLKRLEEEEIKRCK-----ETSEHGAYS 1120 DL +E L+T L + TQ L+ E+E+ K ET H A Sbjct: 1142 RDLG-EELEALKTELEDTLDSTATQ------QELRAKREQEVTVLKKALDEETRSHEAQV 1194 Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP------KVREAAENELRK 1174 ++++ A +E +LT ++ + +R A L K K +E+E +V A+ E+ Sbjct: 1195 QEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252 Query: 1175 QQRNVEDISLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEE 1233 +++ +E +Q+++++ S+ ++ R EL V + + E+E V + EAE K + + Sbjct: 1253 KKKKLE-AQVQELQSKCSDGERARAELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAK 1308 Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRK---DLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290 ++ + +QL++ T+ L++ ++K L LE+++N L ++L + + ++ L + Sbjct: 1309 DVASLSSQLQD---TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365 Query: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVT 1350 I + L+ K+ + + +E +R EI Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI------------------------ 1401 Query: 1351 GLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKL 1410 E+ Q+ EE D+L + +Q++ +L +L+ + ++ E+K R L Sbjct: 1402 ----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457 Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470 E N E +R + + + L R L EEA++ +L++ + + Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARAL-------EEALEAKEELERTNKMLK 1510 Query: 1471 LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELE-----RLQICQR 1525 E+E L K + + V + ++ E ++ + +Q+ DE + RL++ + Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570 Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL-EKSNECAEMLKQK-VEELTRQN 1583 LK QFE+ + +++N +K ++L +L E E + KQ+ + ++ Sbjct: 1571 A---LKGQFERDLQA------RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621 Query: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643 E L +QA+S + ++ ++ L+ Q F+ +L + T ++ + Sbjct: 1622 LEGDLKDLELQADSA--IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679 Query: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703 +K K LE DL + Q ++ ++ Q ++ + +E+ + + NA ++EKRR E ++ Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739 Query: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL-- 1761 + +++E ++ + D + T + + ++ + + K + + ++ ++ ++L Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799 Query: 1762 ----MESKVITE--NDISGIRLDFVSLQQ-------ENSRAQENAKLCETNIKEL----- 1803 ME V ++ + I+ + L++ E A ++ K + +KE+ Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859 Query: 1804 -ERQL-QQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 ER++ +QY+EQ ++G ++ ++ E+E L++++D+ + +E Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915 Score = 140 bits (353), Expect = 2e-32 Identities = 225/1172 (19%), Positives = 485/1172 (41%), Gaps = 190/1172 (16%) Query: 691 EDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIR 750 ED L+ ++E Q + +++ +LE++ + Q +E E+ + E +Y +E +R Sbjct: 858 EDELQKTKERQQKAENELKELEQKHS---QLTEEKNLLQEQLQAETELY----AEAEEMR 910 Query: 751 LRLENCEDRLIRQIRTPLERDDLHESVFRITEQE----KLKKELERLKDDLGTITNKCEE 806 +RL + L + LHE R+ E+E +L+ E +++ + + + EE Sbjct: 911 VRLAAKKQEL---------EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961 Query: 807 F--------FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858 + A + + L E+ +V+ + N N + K + Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEI-LVMDDQN----------------NKLSKERKLL 1004 Query: 859 EALVKLYETKLCEEEAVIAD----KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAK 914 E + T L EEE + KN E++IS L+ + ++ RQ L+ +L+ Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064 Query: 915 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974 + D+H++ AD L + + +Q+ + +L+ Sbjct: 1065 S----------------DFHEQIAD-LQAQIAELKMQLAKKEEELQA----------ALA 1097 Query: 975 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1034 LDD I Q +KI+E + S L L+ ++ ++ E ++ + E E Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGE---ELEALKT 1153 Query: 1035 TVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093 ++D T T + + +Q+ V ++ + + ++R ++ V +T+ + Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1212 Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LENSKLTGKISELERMVAELKK 1152 E+ KR K L + K T+ EN+ L G++ L + E++ Sbjct: 1213 -----------EQFKRAKAN---------LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252 Query: 1153 QKSRVEEELPKVR------EAAENELR----KQQRNVEDISLQKIRAESEAKQYRRELET 1202 +K ++E ++ +++ E A EL K Q VE ++ AE +A + +++ + Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312 Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262 + + + + L+ + + K +EE + ++QL+E ++ LE H+ ++ Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372 Query: 1263 LND------------------------------------------LEQQKNKLMEELRR- 1279 L+D LE+ KN+L +EL Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432 Query: 1280 --KRDNEEELLKLIKQMEKD----LAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR-- 1331 DN+ +L+ +++ ++ LA +K ++ K E+ + E EAR K T+ R Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492 Query: 1332 ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNA 1391 E AL + T+ + + E +++ + V EL + R E M E+ +L Sbjct: 1493 EEALEAKEELERTN--KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550 Query: 1392 LQLEKTSSEE-KARLLKDKLDETNNTLRCLKLELERKDQA-EKGYSQQLRELGRQLNQTT 1449 L+ E ++E+ K RL E N ++ LK + ER QA ++ ++ R+L RQL++ Sbjct: 1551 LEDELQATEDAKLRL------EVN--MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602 Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIH 1509 + E+ ++ + K+ + +L+ L + + D + A K ++ L +Q+ Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDL-------ELQADSAIKGREEAIKQLRKLQAQMK 1655 Query: 1510 SFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE-KSNEC 1568 F ++ELE + + + ++ EK + L ++ +E+ +R ++ + + E Sbjct: 1656 DF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713 Query: 1569 AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK---QTIQQRCEALKIQADGFKDQL 1625 AE L + +E + + RI E + E+ + + R QA+ ++L Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773 Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV-SEFKQKCDQQNIIIQNTKKEVRNL 1684 + K Q +R+ K L L + + V S+FK I +++V Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833 Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744 E A+ + ++ ++K++ QV++ ++ +++ + R++ +EES Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893 Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIR 1776 + + + ++++++ ES +++ ++ Sbjct: 1894 QRINANRRKLQRELDEATESNEAMGREVNALK 1925 Score = 129 bits (325), Expect = 3e-29 Identities = 225/1107 (20%), Positives = 446/1107 (40%), Gaps = 149/1107 (13%) Query: 627 NRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNL 686 N +++ Q L E ++ + + + L E + +R A + E +++L + Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEM 927 Query: 687 QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEV 746 ++R E+ E+ + Q+ Q E+ K+ Q++L E+ E+EE+ E Sbjct: 928 EARLEE--EEDRGQQL-------QAER-----KKMAQQMLDLEEQLEEEEAARQKLQLEK 973 Query: 747 RNIRLRLENCEDRLI----RQIRTPLERDDLHESVFRIT----EQEKLKKELERLKDDLG 798 +++ ED ++ + + ER L E + +T E+E+ K L +LK+ Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033 Query: 799 TITNKCEEFFSQAAAS-SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 857 ++ ++ E + S + L+ +L + ++ + I +LK + L K + Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-MQLAKKEEEL 1092 Query: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA-I 916 AL +L + IA KNN I L+ S++ E A ++ +K K + Sbjct: 1093 QAALARLDDE--------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144 Query: 917 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHV---QIDNRLRDLEGIGKSLKY-YRDT 972 +E+ E + D + + +R Q V V +D R E + ++ + Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204 Query: 973 YHPLDDWIQQVETTQRKIQENQPENSKT---LATQL-----------NQQKMLVSEIEMK 1018 L + ++Q + + + +N+ K LA +L +++K L ++++ Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264 Query: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL- 1077 QSK + ++ + + V + + + M++ + +K + +S +Q+ +L Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324 Query: 1078 --RTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL--------LQRQK 1127 TR V+ + ++ +SL+ +EE++ + H + ++ LQ Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384 Query: 1128 ATV--LENSK---------LTGKISELERMVAELKKQKSRVEEELPKVREAAENE----- 1171 +TV LE K LT + E +L+K K+R+++EL + +N+ Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444 Query: 1172 -LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEA--------------AERELER 1216 L K+QR + + ++ S+ R E REKE A+ ELER Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504 Query: 1217 VRQL------------------TIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258 ++ E E + A+E + + QLEE + ED R Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564 Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQM-EKDLAFQKQVAEKQLKEKQKIEL 1317 ++++ L+ Q + ++ R NEE+ +L +Q+ E + + + ++ L K +L Sbjct: 1565 LEVNMQALKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622 Query: 1318 EARRKITEIQYTC----RENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTA 1373 E K E+Q RE A+ QA Q + +++ E+ + DE+ A Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQA---------QMKDFQRELEDARASRDEIFA 1673 Query: 1374 ANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKG 1433 ++ E+ + L +L LQ E ++ E+AR D E L EL Sbjct: 1674 TAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEE------LAEELASSLSGRNA 1726 Query: 1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRA 1493 + R L ++ Q + EE + R + E L++E + + A Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786 Query: 1494 HAVAEKNIQHLNSQIHSFRD---EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKE 1550 E+ + L S++H K + + K L+EQ E+ + K+ K+ Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846 Query: 1551 NNDKIQRLNEELEKSNECAEMLKQ-------KVEELTRQNNETKLMMQRIQAESENIVLE 1603 + K++ + ++E + AE K+ +V++L RQ E + QRI A + E Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906 Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNE 1630 + EA+ + + K +LR NE Sbjct: 1907 LDEATESNEAMGREVNALKSKLRRGNE 1933 Score = 124 bits (311), Expect = 1e-27 Identities = 215/989 (21%), Positives = 408/989 (41%), Gaps = 143/989 (14%) Query: 673 TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS---DITQLEKEVNVCKQYYQEL-LKS 728 T L +H+ ++S L+ R + + QE + D + +++ + EL ++ Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK--L 786 A++EE+ ++ E+ L+ + L I E D + E++K L Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1144 Query: 787 KKELERLKDDL-GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDK 844 +ELE LK +L T+ + + +A V L+ L+ ++ QV M + Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204 Query: 845 LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH 904 ++ + L+ + A+A + + L +E A +A + + L Q + EV+ K++ Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQEVEHKKKKLE 1258 Query: 905 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 964 A ELQ + D + + + + V + QN + L + EG K Sbjct: 1259 AQVQELQSKCS--------------DGERARAELNDKVHKLQNEVESVTGMLNEAEG--K 1302 Query: 965 SLKYYRDTYHPLDDWIQQVETTQRKIQEN--QPENSKTLATQLNQQK-----MLVSEIEM 1017 ++K +D + Q++ TQ +QE Q N T QL +++ L E+E Sbjct: 1303 AIKLAKD----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358 Query: 1018 KQS----------KMDECQKYAEQYSATV-----------KDYELQTMTYRAMVDSQQKS 1056 KQ+ ++ + +K + +++TV K+ E T Y + K Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418 Query: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116 + R+Q D ++ +DL + + L + KF D L EE+ I Sbjct: 1419 EKTKNRLQQELDDLV---VDLDNQRQLVSNLEKKQRKF--DQLLA-EEKNIS-------- 1464 Query: 1117 GAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQ 1176 Y+D R +A E ++ E K++ R + L E + Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524 Query: 1177 RNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLL 1236 +NV ++ K E++ ++ + +LE + E +A E + +L + +A + E +L Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDL- 1580 Query: 1237 NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL-----I 1291 + + E+N RR L+ L + L D E+++ L ++K + + + L+L I Sbjct: 1581 --QARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAI 1637 Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351 K E+ + Q + + Q+K+ Q+ +AR EI T +EN +A S A Sbjct: 1638 KGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENE------KKAKSLEADL- 1689 Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYEL---NALQLEKTSSEEKARLLKD 1408 +Q + D AE ++Q D + E+ EL L NALQ EK E + L++ Sbjct: 1690 MQLQEDLAAAERARKQAD------LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743 Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL---NQTTGKAEEAMQEASDLKK- 1464 +L+E + + D+ K +QQ +L +L T K E A Q+ K Sbjct: 1744 ELEEEQGNMEAMS------DRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796 Query: 1465 -----------IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD 1513 +K ++ + +L + +L+ +V++ R A K+++ + ++ Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856 Query: 1514 EKELERLQICQRKSDHLKEQFEKSH---EQLLQNIKAEKE-------NNDKIQRLNEELE 1563 + E ER + ++ KEQ EK + +QL + ++ +E N K+QR +E Sbjct: 1857 QVEDER-----KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911 Query: 1564 KSNECAEMLKQKVEELTRQNNETKLMMQR 1592 +SNE ++ R+ NET + R Sbjct: 1912 ESNEAMGREVNALKSKLRRGNETSFVPSR 1940 Score = 80.1 bits (196), Expect = 3e-14 Identities = 220/1120 (19%), Positives = 439/1120 (39%), Gaps = 192/1120 (17%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323 K L++ L E E ++ +D Q+Q +R + + +E LE + + ++ Sbjct: 916 KKQELEEILHEMEARLEEEEDR-----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970 Query: 324 EFESSLKEAKISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQE---RHLDTLH 376 E EAKI +++ + KL + LE + + L +E ++L L Sbjct: 971 -LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029 Query: 377 NFVSRATNELIWLNEKEEE----------EVAYDWSERNTNIARKKDYHAELMRELDQKE 426 N +EL +KEE+ ++ D S+ + IA + AEL +L +KE Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089 Query: 427 ENIKSV-----QEIAEQ-------LLLENHPARL--TIEAYRAAMQTQWSWILQLCQCVE 472 E +++ EIA++ LE H + L +++ RAA L + +E Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149 Query: 473 ------QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526 + ++TA + +E + LK A+ + + + + ++ +++E Sbjct: 1150 ALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALDEE-TRSHEAQVQEMRQKHAQAVE 1206 Query: 527 E-KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585 E E+L Q+K ANL +T L+ N+D + Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQT---LEKENAD----------------------LAGELR 1241 Query: 586 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHI 645 VL + K + S C E D ++++ + ++V + +E+ Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301 Query: 646 NMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSG 705 + A +VAS+ + L ++ L++ ++ Sbjct: 1302 KAIKL--------------AKDVASLSSQLQDT------------QELLQEETRQKLNVS 1335 Query: 706 SDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLR--------LENCE 757 + + QLE+E N + E +++ + E+ S N+ +S+ + +L+ LE + Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK-KLQDFASTVEALEEGK 1394 Query: 758 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817 R ++I ++ E + EK K L++ DDL + + V Sbjct: 1395 KRFQKEIENLTQQ--YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---------V 1443 Query: 818 PTLRSELNVVLQNMNQVYSMSSTYID------------KLKTVNLVLKNTQAAEALVKLY 865 L + Q + + ++SS Y D + K ++L +A EA +L Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503 Query: 866 ETK---LCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQVFHALEDELQKAK---- 914 T E E +++ K+ N+ L + + ++++E + LEDELQ + Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563 Query: 915 --AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972 ++ + K ERDL + + +Q E+ + + Q+ +LE K Sbjct: 1564 RLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618 Query: 973 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY 1032 L+ ++ +E + + E K L Q K E+E ++ DE Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE-------I 1671 Query: 1033 SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM-DLRTRYTALVTLMTQY 1091 AT K+ E + + A + Q+ R + ADL +E +L + + L Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ--- 1728 Query: 1092 IKFAGDSLKRLE------EEEIKRCKETSEHGAYSDLLQR--QKATVLENSKLTGKISEL 1143 D +RLE EEE++ +E A SD +++ Q+A L N T Sbjct: 1729 -----DEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELAT------ 1775 Query: 1144 ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRA-ESEAKQYRRELET 1202 ER A+ K + +R ++L + + ++L + + V+ I A E++ Q ++E Sbjct: 1776 ERSTAQ-KNESAR--QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832 Query: 1203 IVREKEAAEREL----ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258 REK+AA + L ++++++ ++ E +R E+ ++ Q E+ + L+ L+ Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ----YKEQAEKGNARVKQLKRQLEE 1888 Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL 1298 + + + KL EL ++ E + + + ++ L Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928 Score = 69.3 bits (168), Expect = 5e-11 Identities = 109/524 (20%), Positives = 217/524 (41%), Gaps = 80/524 (15%) Query: 1541 LLQNIKAEKE---NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597 LLQ + E+E D++Q+ E +K+ + L+QK +LT + N L+ +++QAE+ Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQEQLQAET 900 Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657 E + E ++++ K +L E LH+ LEE+ + Q Sbjct: 901 E--------LYAEAEEMRVRLAAKKQEL---EEILHEMEAR----------LEEEEDRGQ 939 Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLK 1717 L +E K+ Q +L EE+ QK+QL++ + ++K Sbjct: 940 QLQAERKKMAQQM---------------LDLEEQLEEEEAARQKLQLEKVTAEA---KIK 981 Query: 1718 KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL 1777 K++DE+ + + ++ L +E + E +K + L + K E+ IS + Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE- 1040 Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDEL-- 1835 V L++E QE KL ++LE + EQ+ Q A + K E+EL Sbjct: 1041 --VRLKKEEKSRQELEKL----KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094 Query: 1836 --------IAQKREVENLKQKMDQQIKEHEHQL-----VLLQCEIQKKSTAKDC-TFKPD 1881 IAQK ++++ I + + L + E QK+ ++ K + Sbjct: 1095 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154 Query: 1882 FEMTVKECQHSGELSSRNTGHLHPTPRS-PLLRWTQEPQPLEEKWQH-RVVEQIPKEV-Q 1938 E T+ EL ++ + ++ + E Q E + +H + VE++ +++ Q Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214 Query: 1939 FQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRL-----SEIEKIRDQALNNS 1993 F+ A L+K K Q + + + EL++ + +++++++ + + Sbjct: 1215 FKRAKANLDKNK--QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272 Query: 1994 RPPVRYQDNACEM--ELVKVLTPLEIAKNKQYDMHTEVTTLKQE 2035 R D ++ E+ V L A+ K + +V +L + Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 155 bits (391), Expect = 7e-37 Identities = 208/1036 (20%), Positives = 444/1036 (42%), Gaps = 102/1036 (9%) Query: 895 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954 +V + + A EDELQK K ++KA+ ++ + H Q+ Sbjct: 853 QVTRQEEEMQAKEDELQKTKE------------------RQQKAENELKELEQKHSQLTE 894 Query: 955 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014 L+ + L+ + Y ++ ++ +++++E E L + ++ + L +E Sbjct: 895 EKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951 Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV----KRRRMQSSADLI 1070 + +M + ++ E+ A + +L+ +T A + + + + ++ L+ Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011 Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130 + DL T K + E E++ KE L ++ + Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-- 1069 Query: 1131 LENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-A 1189 + S +I++L+ +AELK Q ++ EEEL ++E+ ++ +L+KIR Sbjct: 1070 -DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-----ALKKIREL 1123 Query: 1190 ESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE------ 1243 E + +L++ E+ A + ++ R L E EA + +E+ L + Q E Sbjct: 1124 EGHISDLQEDLDS---ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180 Query: 1244 -ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEEL-------RRKRDNEEELLKLIKQME 1295 E T ++ L++ + + + ++ Q+ + +EEL +R + N ++ + +++ Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240 Query: 1296 KDLAFQKQV--AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ-----ATSCRA 1348 DLA + +V KQ E +K +LEA ++ E+Q C + + + Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEA--QVQELQSKCSDGERARAELNDKVHKLQNEVES 1298 Query: 1349 VTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408 VTG+ E + KA +L + V L++ + ++ ++E T + + + EE+ L+D Sbjct: 1299 VTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357 Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRN 1468 +LDE E+E K E+ + L QL+ + K ++ L++ K+ Sbjct: 1358 QLDE----------EMEAKQNLER----HISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403 Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528 +Q E+E+L + + D++ + ++ + L + + R + + L+ QRK D Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFD 1461 Query: 1529 H-LKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587 L E+ S + + +AE E +K + L + E L+ K EEL R N K Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARALEEALEAK-EELERTNKMLK 1517 Query: 1588 LMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIK 1647 M+ + + +++ +++ AL+ Q + K QL E L + + +D + +++ Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLE 1573 Query: 1648 CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQA 1707 Q L +F++ D Q QN +K R L +L+ + E ++ L A Sbjct: 1574 ------VNMQALKGQFER--DLQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAA 1624 Query: 1708 QVQELNNRLK--KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESK 1765 ++L LK ++Q + +K EE + +++ Q + F++ E+ R +++ + Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRDEIFATA 1682 Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825 E + D + LQ++ + A+ K + +EL +L Q + Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742 Query: 1826 QKCQKLEDELIAQKREVENLK---QKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882 + +LE+EL ++ +E + +K QQ ++ ++L + QK +A+ + + Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802 Query: 1883 EMTVKECQHSGELSSR 1898 E+ K + G + S+ Sbjct: 1803 ELRSKLHEMEGAVKSK 1818 Score = 146 bits (368), Expect = 3e-34 Identities = 214/1136 (18%), Positives = 488/1136 (42%), Gaps = 124/1136 (10%) Query: 769 ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF-SQAAASSSVPTLRSELNVV 827 + D+L ++ R + E KELE+ L N +E ++ + +R L Sbjct: 864 KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923 Query: 828 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 887 Q + ++ +++ + L+ + A L + EEE K +E + + Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983 Query: 888 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 947 K +++++ V ++L K + + +E + + + +L + ++ Sbjct: 984 EAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041 Query: 948 VHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006 + +++ RL+ E + L K R D+ +Q+ Q +I E L QL Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLA 1093 Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066 +++ E++ +++D+ + A++ +A K EL+ D + + + + Sbjct: 1094 KKE---EELQAALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148 Query: 1067 ADLIIQEFMDLRTRYT-ALVTLMTQYIKFAGDSLKRLEEEEIKRCK-----ETSEHGAYS 1120 DL +E L+T L + TQ L+ E+E+ K ET H A Sbjct: 1149 RDLG-EELEALKTELEDTLDSTATQ------QELRAKREQEVTVLKKALDEETRSHEAQV 1201 Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP------KVREAAENELRK 1174 ++++ A +E +LT ++ + +R A L K K +E+E +V A+ E+ Sbjct: 1202 QEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259 Query: 1175 QQRNVEDISLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEE 1233 +++ +E +Q+++++ S+ ++ R EL V + + E+E V + EAE K + + Sbjct: 1260 KKKKLE-AQVQELQSKCSDGERARAELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAK 1315 Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRK---DLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290 ++ + +QL++ T+ L++ ++K L LE+++N L ++L + + ++ L + Sbjct: 1316 DVASLSSQLQD---TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372 Query: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVT 1350 I + L+ K+ + + +E +R EI Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI------------------------ 1408 Query: 1351 GLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKL 1410 E+ Q+ EE D+L + +Q++ +L +L+ + ++ E+K R L Sbjct: 1409 ----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464 Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470 E N E +R + + + L R L EEA++ +L++ + + Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARAL-------EEALEAKEELERTNKMLK 1517 Query: 1471 LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELE-----RLQICQR 1525 E+E L K + + V + ++ E ++ + +Q+ DE + RL++ + Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577 Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL-EKSNECAEMLKQK-VEELTRQN 1583 LK QFE+ + +++N +K ++L +L E E + KQ+ + ++ Sbjct: 1578 A---LKGQFERDLQA------RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628 Query: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643 E L +QA+S + ++ ++ L+ Q F+ +L + T ++ + Sbjct: 1629 LEGDLKDLELQADSA--IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686 Query: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703 +K K LE DL + Q ++ ++ Q ++ + +E+ + + NA ++EKRR E ++ Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746 Query: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL-- 1761 + +++E ++ + D + T + + ++ + + K + + ++ ++ ++L Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806 Query: 1762 ----MESKVITE--NDISGIRLDFVSLQQ-------ENSRAQENAKLCETNIKEL----- 1803 ME V ++ + I+ + L++ E A ++ K + +KE+ Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866 Query: 1804 -ERQL-QQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 ER++ +QY+EQ ++G ++ ++ E+E L++++D+ + +E Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922 Score = 140 bits (353), Expect = 2e-32 Identities = 225/1172 (19%), Positives = 485/1172 (41%), Gaps = 190/1172 (16%) Query: 691 EDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIR 750 ED L+ ++E Q + +++ +LE++ + Q +E E+ + E +Y +E +R Sbjct: 865 EDELQKTKERQQKAENELKELEQKHS---QLTEEKNLLQEQLQAETELY----AEAEEMR 917 Query: 751 LRLENCEDRLIRQIRTPLERDDLHESVFRITEQE----KLKKELERLKDDLGTITNKCEE 806 +RL + L + LHE R+ E+E +L+ E +++ + + + EE Sbjct: 918 VRLAAKKQEL---------EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968 Query: 807 F--------FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858 + A + + L E+ +V+ + N N + K + Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEI-LVMDDQN----------------NKLSKERKLL 1011 Query: 859 EALVKLYETKLCEEEAVIAD----KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAK 914 E + T L EEE + KN E++IS L+ + ++ RQ L+ +L+ Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071 Query: 915 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974 + D+H++ AD L + + +Q+ + +L+ Sbjct: 1072 S----------------DFHEQIAD-LQAQIAELKMQLAKKEEELQA----------ALA 1104 Query: 975 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1034 LDD I Q +KI+E + S L L+ ++ ++ E ++ + E E Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGE---ELEALKT 1160 Query: 1035 TVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093 ++D T T + + +Q+ V ++ + + ++R ++ V +T+ + Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219 Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LENSKLTGKISELERMVAELKK 1152 E+ KR K L + K T+ EN+ L G++ L + E++ Sbjct: 1220 -----------EQFKRAKAN---------LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259 Query: 1153 QKSRVEEELPKVR------EAAENELR----KQQRNVEDISLQKIRAESEAKQYRRELET 1202 +K ++E ++ +++ E A EL K Q VE ++ AE +A + +++ + Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319 Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262 + + + + L+ + + K +EE + ++QL+E ++ LE H+ ++ Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379 Query: 1263 LND------------------------------------------LEQQKNKLMEELRR- 1279 L+D LE+ KN+L +EL Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439 Query: 1280 --KRDNEEELLKLIKQMEKD----LAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR-- 1331 DN+ +L+ +++ ++ LA +K ++ K E+ + E EAR K T+ R Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499 Query: 1332 ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNA 1391 E AL + T+ + + E +++ + V EL + R E M E+ +L Sbjct: 1500 EEALEAKEELERTN--KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557 Query: 1392 LQLEKTSSEE-KARLLKDKLDETNNTLRCLKLELERKDQA-EKGYSQQLRELGRQLNQTT 1449 L+ E ++E+ K RL E N ++ LK + ER QA ++ ++ R+L RQL++ Sbjct: 1558 LEDELQATEDAKLRL------EVN--MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609 Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIH 1509 + E+ ++ + K+ + +L+ L + + D + A K ++ L +Q+ Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDL-------ELQADSAIKGREEAIKQLRKLQAQMK 1662 Query: 1510 SFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE-KSNEC 1568 F ++ELE + + + ++ EK + L ++ +E+ +R ++ + + E Sbjct: 1663 DF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720 Query: 1569 AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK---QTIQQRCEALKIQADGFKDQL 1625 AE L + +E + + RI E + E+ + + R QA+ ++L Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780 Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV-SEFKQKCDQQNIIIQNTKKEVRNL 1684 + K Q +R+ K L L + + V S+FK I +++V Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840 Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744 E A+ + ++ ++K++ QV++ ++ +++ + R++ +EES Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900 Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIR 1776 + + + ++++++ ES +++ ++ Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALK 1932 Score = 129 bits (325), Expect = 3e-29 Identities = 225/1107 (20%), Positives = 446/1107 (40%), Gaps = 149/1107 (13%) Query: 627 NRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNL 686 N +++ Q L E ++ + + + L E + +R A + E +++L + Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEM 934 Query: 687 QSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEV 746 ++R E+ E+ + Q+ Q E+ K+ Q++L E+ E+EE+ E Sbjct: 935 EARLEE--EEDRGQQL-------QAER-----KKMAQQMLDLEEQLEEEEAARQKLQLEK 980 Query: 747 RNIRLRLENCEDRLI----RQIRTPLERDDLHESVFRIT----EQEKLKKELERLKDDLG 798 +++ ED ++ + + ER L E + +T E+E+ K L +LK+ Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040 Query: 799 TITNKCEEFFSQAAAS-SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA 857 ++ ++ E + S + L+ +L + ++ + I +LK + L K + Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-MQLAKKEEEL 1099 Query: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKA-I 916 AL +L + IA KNN I L+ S++ E A ++ +K K + Sbjct: 1100 QAALARLDDE--------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 917 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHV---QIDNRLRDLEGIGKSLKY-YRDT 972 +E+ E + D + + +R Q V V +D R E + ++ + Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211 Query: 973 YHPLDDWIQQVETTQRKIQENQPENSKT---LATQL-----------NQQKMLVSEIEMK 1018 L + ++Q + + + +N+ K LA +L +++K L ++++ Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271 Query: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL- 1077 QSK + ++ + + V + + + M++ + +K + +S +Q+ +L Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331 Query: 1078 --RTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL--------LQRQK 1127 TR V+ + ++ +SL+ +EE++ + H + ++ LQ Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391 Query: 1128 ATV--LENSK---------LTGKISELERMVAELKKQKSRVEEELPKVREAAENE----- 1171 +TV LE K LT + E +L+K K+R+++EL + +N+ Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451 Query: 1172 -LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEA--------------AERELER 1216 L K+QR + + ++ S+ R E REKE A+ ELER Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511 Query: 1217 VRQL------------------TIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258 ++ E E + A+E + + QLEE + ED R Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571 Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQM-EKDLAFQKQVAEKQLKEKQKIEL 1317 ++++ L+ Q + ++ R NEE+ +L +Q+ E + + + ++ L K +L Sbjct: 1572 LEVNMQALKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629 Query: 1318 EARRKITEIQYTC----RENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTA 1373 E K E+Q RE A+ QA Q + +++ E+ + DE+ A Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQA---------QMKDFQRELEDARASRDEIFA 1680 Query: 1374 ANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKG 1433 ++ E+ + L +L LQ E ++ E+AR D E L EL Sbjct: 1681 TAKENEKKAKSLEADLMQLQ-EDLAAAERARKQADLEKEE------LAEELASSLSGRNA 1733 Query: 1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRA 1493 + R L ++ Q + EE + R + E L++E + + A Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793 Query: 1494 HAVAEKNIQHLNSQIHSFRD---EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKE 1550 E+ + L S++H K + + K L+EQ E+ + K+ K+ Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853 Query: 1551 NNDKIQRLNEELEKSNECAEMLKQ-------KVEELTRQNNETKLMMQRIQAESENIVLE 1603 + K++ + ++E + AE K+ +V++L RQ E + QRI A + E Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913 Query: 1604 KQTIQQRCEALKIQADGFKDQLRSTNE 1630 + EA+ + + K +LR NE Sbjct: 1914 LDEATESNEAMGREVNALKSKLRRGNE 1940 Score = 124 bits (311), Expect = 1e-27 Identities = 215/989 (21%), Positives = 408/989 (41%), Gaps = 143/989 (14%) Query: 673 TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS---DITQLEKEVNVCKQYYQEL-LKS 728 T L +H+ ++S L+ R + + QE + D + +++ + EL ++ Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK--L 786 A++EE+ ++ E+ L+ + L I E D + E++K L Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 787 KKELERLKDDL-GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDK 844 +ELE LK +L T+ + + +A V L+ L+ ++ QV M + Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211 Query: 845 LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH 904 ++ + L+ + A+A + + L +E A +A + + L Q + EV+ K++ Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQEVEHKKKKLE 1265 Query: 905 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 964 A ELQ + D + + + + V + QN + L + EG K Sbjct: 1266 AQVQELQSKCS--------------DGERARAELNDKVHKLQNEVESVTGMLNEAEG--K 1309 Query: 965 SLKYYRDTYHPLDDWIQQVETTQRKIQEN--QPENSKTLATQLNQQK-----MLVSEIEM 1017 ++K +D + Q++ TQ +QE Q N T QL +++ L E+E Sbjct: 1310 AIKLAKD----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365 Query: 1018 KQS----------KMDECQKYAEQYSATV-----------KDYELQTMTYRAMVDSQQKS 1056 KQ+ ++ + +K + +++TV K+ E T Y + K Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425 Query: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116 + R+Q D ++ +DL + + L + KF D L EE+ I Sbjct: 1426 EKTKNRLQQELDDLV---VDLDNQRQLVSNLEKKQRKF--DQLLA-EEKNIS-------- 1471 Query: 1117 GAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQ 1176 Y+D R +A E ++ E K++ R + L E + Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531 Query: 1177 RNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLL 1236 +NV ++ K E++ ++ + +LE + E +A E + +L + +A + E +L Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDL- 1587 Query: 1237 NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL-----I 1291 + + E+N RR L+ L + L D E+++ L ++K + + + L+L I Sbjct: 1588 --QARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAI 1644 Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351 K E+ + Q + + Q+K+ Q+ +AR EI T +EN +A S A Sbjct: 1645 KGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENE------KKAKSLEADL- 1696 Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYEL---NALQLEKTSSEEKARLLKD 1408 +Q + D AE ++Q D + E+ EL L NALQ EK E + L++ Sbjct: 1697 MQLQEDLAAAERARKQAD------LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750 Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL---NQTTGKAEEAMQEASDLKK- 1464 +L+E + + D+ K +QQ +L +L T K E A Q+ K Sbjct: 1751 ELEEEQGNMEAMS------DRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803 Query: 1465 -----------IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD 1513 +K ++ + +L + +L+ +V++ R A K+++ + ++ Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863 Query: 1514 EKELERLQICQRKSDHLKEQFEKSH---EQLLQNIKAEKE-------NNDKIQRLNEELE 1563 + E ER + ++ KEQ EK + +QL + ++ +E N K+QR +E Sbjct: 1864 QVEDER-----KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918 Query: 1564 KSNECAEMLKQKVEELTRQNNETKLMMQR 1592 +SNE ++ R+ NET + R Sbjct: 1919 ESNEAMGREVNALKSKLRRGNETSFVPSR 1947 Score = 80.1 bits (196), Expect = 3e-14 Identities = 220/1120 (19%), Positives = 439/1120 (39%), Gaps = 192/1120 (17%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323 K L++ L E E ++ +D Q+Q +R + + +E LE + + ++ Sbjct: 923 KKQELEEILHEMEARLEEEEDR-----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977 Query: 324 EFESSLKEAKISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQE---RHLDTLH 376 E EAKI +++ + KL + LE + + L +E ++L L Sbjct: 978 -LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036 Query: 377 NFVSRATNELIWLNEKEEE----------EVAYDWSERNTNIARKKDYHAELMRELDQKE 426 N +EL +KEE+ ++ D S+ + IA + AEL +L +KE Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096 Query: 427 ENIKSV-----QEIAEQ-------LLLENHPARL--TIEAYRAAMQTQWSWILQLCQCVE 472 E +++ EIA++ LE H + L +++ RAA L + +E Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156 Query: 473 ------QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526 + ++TA + +E + LK A+ + + + + ++ +++E Sbjct: 1157 ALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALDEE-TRSHEAQVQEMRQKHAQAVE 1213 Query: 527 E-KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585 E E+L Q+K ANL +T L+ N+D + Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQT---LEKENAD----------------------LAGELR 1248 Query: 586 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHI 645 VL + K + S C E D ++++ + ++V + +E+ Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308 Query: 646 NMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSG 705 + A +VAS+ + L ++ L++ ++ Sbjct: 1309 KAIKL--------------AKDVASLSSQLQDT------------QELLQEETRQKLNVS 1342 Query: 706 SDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLR--------LENCE 757 + + QLE+E N + E +++ + E+ S N+ +S+ + +L+ LE + Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK-KLQDFASTVEALEEGK 1401 Query: 758 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817 R ++I ++ E + EK K L++ DDL + + V Sbjct: 1402 KRFQKEIENLTQQ--YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---------V 1450 Query: 818 PTLRSELNVVLQNMNQVYSMSSTYID------------KLKTVNLVLKNTQAAEALVKLY 865 L + Q + + ++SS Y D + K ++L +A EA +L Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510 Query: 866 ETK---LCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQVFHALEDELQKAK---- 914 T E E +++ K+ N+ L + + ++++E + LEDELQ + Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570 Query: 915 --AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972 ++ + K ERDL + + +Q E+ + + Q+ +LE K Sbjct: 1571 RLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625 Query: 973 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY 1032 L+ ++ +E + + E K L Q K E+E ++ DE Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE-------I 1678 Query: 1033 SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM-DLRTRYTALVTLMTQY 1091 AT K+ E + + A + Q+ R + ADL +E +L + + L Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ--- 1735 Query: 1092 IKFAGDSLKRLE------EEEIKRCKETSEHGAYSDLLQR--QKATVLENSKLTGKISEL 1143 D +RLE EEE++ +E A SD +++ Q+A L N T Sbjct: 1736 -----DEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELAT------ 1782 Query: 1144 ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRA-ESEAKQYRRELET 1202 ER A+ K + +R ++L + + ++L + + V+ I A E++ Q ++E Sbjct: 1783 ERSTAQ-KNESAR--QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839 Query: 1203 IVREKEAAEREL----ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258 REK+AA + L ++++++ ++ E +R E+ ++ Q E+ + L+ L+ Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ----YKEQAEKGNARVKQLKRQLEE 1895 Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL 1298 + + + KL EL ++ E + + + ++ L Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935 Score = 69.3 bits (168), Expect = 5e-11 Identities = 109/524 (20%), Positives = 217/524 (41%), Gaps = 80/524 (15%) Query: 1541 LLQNIKAEKE---NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597 LLQ + E+E D++Q+ E +K+ + L+QK +LT + N L+ +++QAE+ Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQEQLQAET 907 Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657 E + E ++++ K +L E LH+ LEE+ + Q Sbjct: 908 E--------LYAEAEEMRVRLAAKKQEL---EEILHEMEAR----------LEEEEDRGQ 946 Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLK 1717 L +E K+ Q +L EE+ QK+QL++ + ++K Sbjct: 947 QLQAERKKMAQQM---------------LDLEEQLEEEEAARQKLQLEKVTAEA---KIK 988 Query: 1718 KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL 1777 K++DE+ + + ++ L +E + E +K + L + K E+ IS + Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE- 1047 Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDEL-- 1835 V L++E QE KL ++LE + EQ+ Q A + K E+EL Sbjct: 1048 --VRLKKEEKSRQELEKL----KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101 Query: 1836 --------IAQKREVENLKQKMDQQIKEHEHQL-----VLLQCEIQKKSTAKDC-TFKPD 1881 IAQK ++++ I + + L + E QK+ ++ K + Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161 Query: 1882 FEMTVKECQHSGELSSRNTGHLHPTPRS-PLLRWTQEPQPLEEKWQH-RVVEQIPKEV-Q 1938 E T+ EL ++ + ++ + E Q E + +H + VE++ +++ Q Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221 Query: 1939 FQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRL-----SEIEKIRDQALNNS 1993 F+ A L+K K Q + + + EL++ + +++++++ + + Sbjct: 1222 FKRAKANLDKNK--QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279 Query: 1994 RPPVRYQDNACEM--ELVKVLTPLEIAKNKQYDMHTEVTTLKQE 2035 R D ++ E+ V L A+ K + +V +L + Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 155 bits (391), Expect = 7e-37 Identities = 208/1036 (20%), Positives = 444/1036 (42%), Gaps = 102/1036 (9%) Query: 895 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 954 +V + + A EDELQK K ++KA+ ++ + H Q+ Sbjct: 853 QVTRQEEEMQAKEDELQKTKE------------------RQQKAENELKELEQKHSQLTE 894 Query: 955 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014 L+ + L+ + Y ++ ++ +++++E E L + ++ + L +E Sbjct: 895 EKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951 Query: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV----KRRRMQSSADLI 1070 + +M + ++ E+ A + +L+ +T A + + + + ++ L+ Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011 Query: 1071 IQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV 1130 + DL T K + E E++ KE L ++ + Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-- 1069 Query: 1131 LENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-A 1189 + S +I++L+ +AELK Q ++ EEEL ++E+ ++ +L+KIR Sbjct: 1070 -DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-----ALKKIREL 1123 Query: 1190 ESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE------ 1243 E + +L++ E+ A + ++ R L E EA + +E+ L + Q E Sbjct: 1124 EGHISDLQEDLDS---ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180 Query: 1244 -ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEEL-------RRKRDNEEELLKLIKQME 1295 E T ++ L++ + + + ++ Q+ + +EEL +R + N ++ + +++ Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240 Query: 1296 KDLAFQKQV--AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ-----ATSCRA 1348 DLA + +V KQ E +K +LEA ++ E+Q C + + + Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEA--QVQELQSKCSDGERARAELNDKVHKLQNEVES 1298 Query: 1349 VTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408 VTG+ E + KA +L + V L++ + ++ ++E T + + + EE+ L+D Sbjct: 1299 VTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357 Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRN 1468 +LDE E+E K E+ + L QL+ + K ++ L++ K+ Sbjct: 1358 QLDE----------EMEAKQNLER----HISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403 Query: 1469 YQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSD 1528 +Q E+E+L + + D++ + ++ + L + + R + + L+ QRK D Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFD 1461 Query: 1529 H-LKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587 L E+ S + + +AE E +K + L + E L+ K EEL R N K Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARALEEALEAK-EELERTNKMLK 1517 Query: 1588 LMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIK 1647 M+ + + +++ +++ AL+ Q + K QL E L + + +D + +++ Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLE 1573 Query: 1648 CLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQA 1707 Q L +F++ D Q QN +K R L +L+ + E ++ L A Sbjct: 1574 ------VNMQALKGQFER--DLQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAA 1624 Query: 1708 QVQELNNRLK--KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESK 1765 ++L LK ++Q + +K EE + +++ Q + F++ E+ R +++ + Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRDEIFATA 1682 Query: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825 E + D + LQ++ + A+ K + +EL +L Q + Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742 Query: 1826 QKCQKLEDELIAQKREVENLK---QKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDF 1882 + +LE+EL ++ +E + +K QQ ++ ++L + QK +A+ + + Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802 Query: 1883 EMTVKECQHSGELSSR 1898 E+ K + G + S+ Sbjct: 1803 ELRSKLHEMEGAVKSK 1818 Score = 146 bits (368), Expect = 3e-34 Identities = 214/1136 (18%), Positives = 488/1136 (42%), Gaps = 124/1136 (10%) Query: 769 ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF-SQAAASSSVPTLRSELNVV 827 + D+L ++ R + E KELE+ L N +E ++ + +R L Sbjct: 864 KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923 Query: 828 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 887 Q + ++ +++ + L+ + A L + EEE K +E + + Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983 Query: 888 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 947 K +++++ V ++L K + + +E + + + +L + ++ Sbjct: 984 EAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041 Query: 948 VHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006 + +++ RL+ E + L K R D+ +Q+ Q +I E L QL Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLA 1093 Query: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066 +++ E++ +++D+ + A++ +A K EL+ D + + + + Sbjct: 1094 KKE---EELQAALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148 Query: 1067 ADLIIQEFMDLRTRYT-ALVTLMTQYIKFAGDSLKRLEEEEIKRCK-----ETSEHGAYS 1120 DL +E L+T L + TQ L+ E+E+ K ET H A Sbjct: 1149 RDLG-EELEALKTELEDTLDSTATQ------QELRAKREQEVTVLKKALDEETRSHEAQV 1201 Query: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP------KVREAAENELRK 1174 ++++ A +E +LT ++ + +R A L K K +E+E +V A+ E+ Sbjct: 1202 QEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259 Query: 1175 QQRNVEDISLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEE 1233 +++ +E +Q+++++ S+ ++ R EL V + + E+E V + EAE K + + Sbjct: 1260 KKKKLE-AQVQELQSKCSDGERARAELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAK 1315 Query: 1234 NLLNFRNQLEENTFTRRTLEDHLKRK---DLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290 ++ + +QL++ T+ L++ ++K L LE+++N L ++L + + ++ L + Sbjct: 1316 DVASLSSQLQD---TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372 Query: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVT 1350 I + L+ K+ + + +E +R EI Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI------------------------ 1408 Query: 1351 GLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKL 1410 E+ Q+ EE D+L + +Q++ +L +L+ + ++ E+K R L Sbjct: 1409 ----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464 Query: 1411 DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470 E N E +R + + + L R L EEA++ +L++ + + Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARAL-------EEALEAKEELERTNKMLK 1517 Query: 1471 LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELE-----RLQICQR 1525 E+E L K + + V + ++ E ++ + +Q+ DE + RL++ + Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577 Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL-EKSNECAEMLKQK-VEELTRQN 1583 LK QFE+ + +++N +K ++L +L E E + KQ+ + ++ Sbjct: 1578 A---LKGQFERDLQA------RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628 Query: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643 E L +QA+S + ++ ++ L+ Q F+ +L + T ++ + Sbjct: 1629 LEGDLKDLELQADSA--IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686 Query: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703 +K K LE DL + Q ++ ++ Q ++ + +E+ + + NA ++EKRR E ++ Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746 Query: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL-- 1761 + +++E ++ + D + T + + ++ + + K + + ++ ++ ++L Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806 Query: 1762 ----MESKVITE--NDISGIRLDFVSLQQ-------ENSRAQENAKLCETNIKEL----- 1803 ME V ++ + I+ + L++ E A ++ K + +KE+ Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866 Query: 1804 -ERQL-QQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857 ER++ +QY+EQ ++G ++ ++ E+E L++++D+ + +E Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922 Score = 140 bits (353), Expect = 2e-32 Identities = 225/1172 (19%), Positives = 485/1172 (41%), Gaps = 190/1172 (16%) Query: 691 EDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIR 750 ED L+ ++E Q + +++ +LE++ + Q +E E+ + E +Y +E +R Sbjct: 865 EDELQKTKERQQKAENELKELEQKHS---QLTEEKNLLQEQLQAETELY----AEAEEMR 917 Query: 751 LRLENCEDRLIRQIRTPLERDDLHESVFRITEQE----KLKKELERLKDDLGTITNKCEE 806 +RL + L + LHE R+ E+E +L+ E +++ + + + EE Sbjct: 918 VRLAAKKQEL---------EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968 Query: 807 F--------FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 858 + A + + L E+ +V+ + N N + K + Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEI-LVMDDQN----------------NKLSKERKLL 1011 Query: 859 EALVKLYETKLCEEEAVIAD----KNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAK 914 E + T L EEE + KN E++IS L+ + ++ RQ L+ +L+ Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071 Query: 915 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974 + D+H++ AD L + + +Q+ + +L+ Sbjct: 1072 S----------------DFHEQIAD-LQAQIAELKMQLAKKEEELQA----------ALA 1104 Query: 975 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1034 LDD I Q +KI+E + S L L+ ++ ++ E ++ + E E Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGE---ELEALKT 1160 Query: 1035 TVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1093 ++D T T + + +Q+ V ++ + + ++R ++ V +T+ + Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219 Query: 1094 FAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LENSKLTGKISELERMVAELKK 1152 E+ KR K L + K T+ EN+ L G++ L + E++ Sbjct: 1220 -----------EQFKRAKAN---------LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259 Query: 1153 QKSRVEEELPKVR------EAAENELR----KQQRNVEDISLQKIRAESEAKQYRRELET 1202 +K ++E ++ +++ E A EL K Q VE ++ AE +A + +++ + Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319 Query: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262 + + + + L+ + + K +EE + ++QL+E ++ LE H+ ++ Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379 Query: 1263 LND------------------------------------------LEQQKNKLMEELRR- 1279 L+D LE+ KN+L +EL Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439 Query: 1280 --KRDNEEELLKLIKQMEKD----LAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR-- 1331 DN+ +L+ +++ ++ LA +K ++ K E+ + E EAR K T+ R Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499 Query: 1332 ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNA 1391 E AL + T+ + + E +++ + V EL + R E M E+ +L Sbjct: 1500 EEALEAKEELERTN--KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557 Query: 1392 LQLEKTSSEE-KARLLKDKLDETNNTLRCLKLELERKDQA-EKGYSQQLRELGRQLNQTT 1449 L+ E ++E+ K RL E N ++ LK + ER QA ++ ++ R+L RQL++ Sbjct: 1558 LEDELQATEDAKLRL------EVN--MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609 Query: 1450 GKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIH 1509 + E+ ++ + K+ + +L+ L + + D + A K ++ L +Q+ Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDL-------ELQADSAIKGREEAIKQLRKLQAQMK 1662 Query: 1510 SFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE-KSNEC 1568 F ++ELE + + + ++ EK + L ++ +E+ +R ++ + + E Sbjct: 1663 DF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720 Query: 1569 AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK---QTIQQRCEALKIQADGFKDQL 1625 AE L + +E + + RI E + E+ + + R QA+ ++L Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780 Query: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV-SEFKQKCDQQNIIIQNTKKEVRNL 1684 + K Q +R+ K L L + + V S+FK I +++V Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840 Query: 1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEES 1744 E A+ + ++ ++K++ QV++ ++ +++ + R++ +EES Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900 Query: 1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIR 1776 + + + ++++++ ES +++ ++ Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALK 1932 Score = 125 bits (313), Expect = 7e-28 Identities = 218/995 (21%), Positives = 403/995 (40%), Gaps = 137/995 (13%) Query: 673 TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS---DITQLEKEVNVCKQYYQEL-LKS 728 T L +H+ ++S L+ R + + QE + D + +++ + EL ++ Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092 Query: 729 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK--L 786 A++EE+ ++ E+ L+ + L I E D + E++K L Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 787 KKELERLKDDL-GTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDK 844 +ELE LK +L T+ + + +A V L+ L+ ++ QV M + Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211 Query: 845 LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH 904 ++ + L+ + A+A + + L +E A +A + + L Q + EV+ K++ Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQEVEHKKKKLE 1265 Query: 905 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 964 A ELQ + D + + + + V + QN + L + EG K Sbjct: 1266 AQVQELQSKCS--------------DGERARAELNDKVHKLQNEVESVTGMLNEAEG--K 1309 Query: 965 SLKYYRDTYHPLDDWIQQVETTQRKIQEN--QPENSKTLATQLNQQK-----MLVSEIEM 1017 ++K +D + Q++ TQ +QE Q N T QL +++ L E+E Sbjct: 1310 AIKLAKD----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365 Query: 1018 KQS----------KMDECQKYAEQYSATV-----------KDYELQTMTYRAMVDSQQKS 1056 KQ+ ++ + +K + +++TV K+ E T Y + K Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425 Query: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116 + R+Q D ++ +DL + + L + KF D L EE+ I Sbjct: 1426 EKTKNRLQQELDDLV---VDLDNQRQLVSNLEKKQRKF--DQLLA-EEKNIS-------- 1471 Query: 1117 GAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQ 1176 Y+D R +A E ++ E K++ R + L E + Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531 Query: 1177 RNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLL 1236 +NV ++ K E++ ++ + +LE + E +A E + +L + +A + E +L Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDL- 1587 Query: 1237 NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL-----I 1291 + + E+N RR L+ L + L D E+++ L ++K + + + L+L I Sbjct: 1588 --QARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAI 1644 Query: 1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351 K E+ + Q + + Q+K+ Q+ +AR EI T +EN +A S A Sbjct: 1645 KGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENE------KKAKSLEADL- 1696 Query: 1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYEL---NALQLEKTSSEEKARLLKD 1408 +Q + D AE ++Q D + E+ EL L NALQ EK E + L++ Sbjct: 1697 MQLQEDLAAAERARKQAD------LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750 Query: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL---NQTTGKAEEAMQEASDLKKI 1465 +L+E + + D+ K +QQ +L +L T K E A Q+ K Sbjct: 1751 ELEEEQGNMEAMS------DRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803 Query: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525 R+ E+E K K A E I L Q+ EK Q Sbjct: 1804 LRSKLHEMEGAVKSKFK---------STIAALEAKIAQLEEQVEQEAREK--------QA 1846 Query: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNE 1585 + LK++ +K E LLQ ++ ++ E+ EK N + LK+++EE ++ Sbjct: 1847 ATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902 Query: 1586 TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG 1620 +++Q E + + + + ALK + G Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937 Score = 80.1 bits (196), Expect = 3e-14 Identities = 220/1120 (19%), Positives = 439/1120 (39%), Gaps = 192/1120 (17%) Query: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323 K L++ L E E ++ +D Q+Q +R + + +E LE + + ++ Sbjct: 923 KKQELEEILHEMEARLEEEEDR-----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977 Query: 324 EFESSLKEAKISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQE---RHLDTLH 376 E EAKI +++ + KL + LE + + L +E ++L L Sbjct: 978 -LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036 Query: 377 NFVSRATNELIWLNEKEEE----------EVAYDWSERNTNIARKKDYHAELMRELDQKE 426 N +EL +KEE+ ++ D S+ + IA + AEL +L +KE Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096 Query: 427 ENIKSV-----QEIAEQ-------LLLENHPARL--TIEAYRAAMQTQWSWILQLCQCVE 472 E +++ EIA++ LE H + L +++ RAA L + +E Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156 Query: 473 ------QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526 + ++TA + +E + LK A+ + + + + ++ +++E Sbjct: 1157 ALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALDEE-TRSHEAQVQEMRQKHAQAVE 1213 Query: 527 E-KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585 E E+L Q+K ANL +T L+ N+D + Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQT---LEKENAD----------------------LAGELR 1248 Query: 586 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHI 645 VL + K + S C E D ++++ + ++V + +E+ Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308 Query: 646 NMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSG 705 + A +VAS+ + L ++ L++ ++ Sbjct: 1309 KAIKL--------------AKDVASLSSQLQDT------------QELLQEETRQKLNVS 1342 Query: 706 SDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLR--------LENCE 757 + + QLE+E N + E +++ + E+ S N+ +S+ + +L+ LE + Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK-KLQDFASTVEALEEGK 1401 Query: 758 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817 R ++I ++ E + EK K L++ DDL + + V Sbjct: 1402 KRFQKEIENLTQQ--YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---------V 1450 Query: 818 PTLRSELNVVLQNMNQVYSMSSTYID------------KLKTVNLVLKNTQAAEALVKLY 865 L + Q + + ++SS Y D + K ++L +A EA +L Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510 Query: 866 ETK---LCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQVFHALEDELQKAK---- 914 T E E +++ K+ N+ L + + ++++E + LEDELQ + Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570 Query: 915 --AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972 ++ + K ERDL + + +Q E+ + + Q+ +LE K Sbjct: 1571 RLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625 Query: 973 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY 1032 L+ ++ +E + + E K L Q K E+E ++ DE Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE-------I 1678 Query: 1033 SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM-DLRTRYTALVTLMTQY 1091 AT K+ E + + A + Q+ R + ADL +E +L + + L Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ--- 1735 Query: 1092 IKFAGDSLKRLE------EEEIKRCKETSEHGAYSDLLQR--QKATVLENSKLTGKISEL 1143 D +RLE EEE++ +E A SD +++ Q+A L N T Sbjct: 1736 -----DEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELAT------ 1782 Query: 1144 ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRA-ESEAKQYRRELET 1202 ER A+ K + +R ++L + + ++L + + V+ I A E++ Q ++E Sbjct: 1783 ERSTAQ-KNESAR--QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839 Query: 1203 IVREKEAAEREL----ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258 REK+AA + L ++++++ ++ E +R E+ ++ Q E+ + L+ L+ Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ----YKEQAEKGNARVKQLKRQLEE 1895 Query: 1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL 1298 + + + KL EL ++ E + + + ++ L Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935 Score = 69.3 bits (168), Expect = 5e-11 Identities = 109/524 (20%), Positives = 217/524 (41%), Gaps = 80/524 (15%) Query: 1541 LLQNIKAEKE---NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597 LLQ + E+E D++Q+ E +K+ + L+QK +LT + N L+ +++QAE+ Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQEQLQAET 907 Query: 1598 ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657 E + E ++++ K +L E LH+ LEE+ + Q Sbjct: 908 E--------LYAEAEEMRVRLAAKKQEL---EEILHEMEAR----------LEEEEDRGQ 946 Query: 1658 NLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLK 1717 L +E K+ Q +L EE+ QK+QL++ + ++K Sbjct: 947 QLQAERKKMAQQM---------------LDLEEQLEEEEAARQKLQLEKVTAEA---KIK 988 Query: 1718 KVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL 1777 K++DE+ + + ++ L +E + E +K + L + K E+ IS + Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE- 1047 Query: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDEL-- 1835 V L++E QE KL ++LE + EQ+ Q A + K E+EL Sbjct: 1048 --VRLKKEEKSRQELEKL----KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101 Query: 1836 --------IAQKREVENLKQKMDQQIKEHEHQL-----VLLQCEIQKKSTAKDC-TFKPD 1881 IAQK ++++ I + + L + E QK+ ++ K + Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161 Query: 1882 FEMTVKECQHSGELSSRNTGHLHPTPRS-PLLRWTQEPQPLEEKWQH-RVVEQIPKEV-Q 1938 E T+ EL ++ + ++ + E Q E + +H + VE++ +++ Q Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221 Query: 1939 FQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRL-----SEIEKIRDQALNNS 1993 F+ A L+K K Q + + + EL++ + +++++++ + + Sbjct: 1222 FKRAKANLDKNK--QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279 Query: 1994 RPPVRYQDNACEM--ELVKVLTPLEIAKNKQYDMHTEVTTLKQE 2035 R D ++ E+ V L A+ K + +V +L + Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.128 0.351 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 90,199,211 Number of Sequences: 37866 Number of extensions: 4093044 Number of successful extensions: 46844 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 528 Number of HSP's successfully gapped in prelim test: 1402 Number of HSP's that attempted gapping in prelim test: 15869 Number of HSP's gapped (non-prelim): 12932 length of query: 2649 length of database: 18,247,518 effective HSP length: 119 effective length of query: 2530 effective length of database: 13,741,464 effective search space: 34765903920 effective search space used: 34765903920 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.