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Search of human proteins with 4502435
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
(675 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 1385 0.0
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 1385 0.0
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 649 0.0
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 608 e-174
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 565 e-161
gi|148596974 TXK tyrosine kinase [Homo sapiens] 470 e-132
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 293 3e-79
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 293 3e-79
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 287 2e-77
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 287 2e-77
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 285 1e-76
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 285 1e-76
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 285 1e-76
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 285 1e-76
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 285 1e-76
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 282 6e-76
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 279 7e-75
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 279 7e-75
gi|4503787 fyn-related kinase [Homo sapiens] 278 2e-74
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 274 2e-73
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 274 2e-73
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 273 5e-73
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 273 5e-73
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 270 4e-72
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 267 2e-71
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 267 2e-71
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 267 2e-71
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 267 2e-71
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 258 1e-68
gi|187475373 c-src tyrosine kinase [Homo sapiens] 251 2e-66
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 1385 bits (3586), Expect = 0.0
Identities = 675/675 (100%), Positives = 675/675 (100%)
Query: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
Sbjct: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
Query: 61 RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY 120
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
Sbjct: 61 RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY 120
Query: 121 HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL 180
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
Sbjct: 121 HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL 180
Query: 181 KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF 240
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
Sbjct: 181 KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF 240
Query: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN 300
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
Sbjct: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN 300
Query: 301 ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY 360
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
Sbjct: 301 ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY 360
Query: 361 LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL 420
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
Sbjct: 361 LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL 420
Query: 421 KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS 480
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
Sbjct: 421 KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS 480
Query: 481 KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR 540
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
Sbjct: 481 KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR 540
Query: 541 NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI 600
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
Sbjct: 541 NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI 600
Query: 601 LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ 660
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
Sbjct: 601 LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ 660
Query: 661 QLLSSIEPLREKDKH 675
QLLSSIEPLREKDKH
Sbjct: 661 QLLSSIEPLREKDKH 675
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 1385 bits (3586), Expect = 0.0
Identities = 675/675 (100%), Positives = 675/675 (100%)
Query: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
Sbjct: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
Query: 61 RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY 120
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
Sbjct: 61 RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY 120
Query: 121 HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL 180
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
Sbjct: 121 HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL 180
Query: 181 KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF 240
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
Sbjct: 181 KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF 240
Query: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN 300
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
Sbjct: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN 300
Query: 301 ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY 360
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
Sbjct: 301 ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY 360
Query: 361 LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL 420
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
Sbjct: 361 LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL 420
Query: 421 KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS 480
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
Sbjct: 421 KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS 480
Query: 481 KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR 540
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
Sbjct: 481 KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR 540
Query: 541 NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI 600
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
Sbjct: 541 NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI 600
Query: 601 LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ 660
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
Sbjct: 601 LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ 660
Query: 661 QLLSSIEPLREKDKH 675
QLLSSIEPLREKDKH
Sbjct: 661 QLLSSIEPLREKDKH 675
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 649 bits (1673), Expect = 0.0
Identities = 335/693 (48%), Positives = 454/693 (65%), Gaps = 64/693 (9%)
Query: 6 ILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYD--KMKRGSRKGSIEIKKIRCV 63
ILE + LKRSQQKKK SP N+K+RLF+LT LSYYEYD + +RGS+KGSI+++KI CV
Sbjct: 5 ILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCV 64
Query: 64 EKVNLEEQTPVERQ---------------------YPFQIVYKDGLLYVYASNEESRSQW 102
E V E+ P ERQ YPFQ+VY +G LYV++ EE R +W
Sbjct: 65 ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRW 124
Query: 103 LKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWE-AYANLHTAVNEEKH 161
+ L+ IR N L+ KYH F++DG++LCC Q+ K A GC + E +L + K
Sbjct: 125 IHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKT 184
Query: 162 RVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSK 221
+ P P P +LK P +E KK +A YD
Sbjct: 185 KKPLPPT-----PEEDQILKKPLPPEPAAAPVSTSELKK-----------VVALYDYMPM 228
Query: 222 KIYGSQPNFNMQY-IPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFP 280
Q +Y I E WW+ R N +E + P
Sbjct: 229 NANDLQLRKGDEYFILEESNLPWWRAR------------DKNGQEGYI-----------P 265
Query: 281 ESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVN 340
+ +E E++++ Y+W++ +++RSQ+EQLL+Q+GKEG F+VR+SS+ G YTVS+F+K+
Sbjct: 266 SNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG 325
Query: 341 DKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVP 400
D +G ++HY V + +++ YLAE + F +IP+LI+YHQHNSAG+I+RL++PVS + P
Sbjct: 326 DPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAP 385
Query: 401 DSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQE 460
+ LG G WE+ +++T LKELG+GQFGVV+ GKW+GQYDVA+KMIKEGSMSEDEF +E
Sbjct: 386 STAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEE 445
Query: 461 AQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDV 520
A+ MM LSH KLV+ YGVC+K+ PI+I+TEY++NGCLLNYLR + QLLEMC DV
Sbjct: 446 AKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 505
Query: 521 CEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSA 580
CE M +LES QF+HRDLAARNCLV+ VKVSDFG++RYVLDD+Y SSVG+KFPV+WS
Sbjct: 506 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSP 565
Query: 581 PEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDT 640
PEV Y K+SSKSD+WAFG+LMWE++SLGK PY+ + NS+ ++QG RLYRPHLAS+
Sbjct: 566 PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEK 625
Query: 641 IYQIMYSCWHELPEKRPTFQQLLSSIEPLREKD 673
+Y IMYSCWHE ++RPTF+ LLS+I + +++
Sbjct: 626 VYTIMYSCWHEKADERPTFKILLSNILDVMDEE 658
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 608 bits (1567), Expect = e-174
Identities = 313/675 (46%), Positives = 430/675 (63%), Gaps = 55/675 (8%)
Query: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
M+ +ILEE+L+KRSQQKKK SP NYKERLFVLTK+ L+YYE + ++ RKG I++ KI
Sbjct: 1 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE-GRAEKKYRKGFIDVSKI 59
Query: 61 RCVEKVNLEEQT-PVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVK 119
+CVE V ++ P + +YPFQ+V+ LY++A + +SR W+K L++EI+ N ++++K
Sbjct: 60 KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
Query: 120 YHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPV 179
YH F+ DG + CC+Q+ K APGC EK+ + F + K P
Sbjct: 120 YHPKFWTDGSYQCCRQTEKLAPGC---------------EKYNL--FESSIRKALPPAPE 162
Query: 180 LKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPRE- 238
K P L + DN S +A YD + + + + +Y+ E
Sbjct: 163 TKKRRPPPPIPLEEEDN-----------SEEIVVAMYDFQAAEGHDLRLERGQEYLILEK 211
Query: 239 DFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFA 298
+ WW+ R N+ N+ T K S NLD Y+W+
Sbjct: 212 NDVHWWRARD----------KYGNEGYIPSNYVTGKKS------------NNLDQYEWYC 249
Query: 299 GNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVH--TNAE 356
N++RS++EQLLR + KEG FMVR+SSQ G+YTVSL++K + +HYH+ T +
Sbjct: 250 RNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSP 309
Query: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416
K YLAE + F SIP++I YH+HN+AG++TRLR+PVS K P + WE+ E
Sbjct: 310 KKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSE 369
Query: 417 ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY 476
+T ++ELGSG FGVV+LGKW+ QY VA+K I+EG+M E++F +EA+ MMKL+HPKLV+ Y
Sbjct: 370 LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY 429
Query: 477 GVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRD 536
GVC+++ PIYIVTE++ GCLLN+LR LL MC DVCEGM +LE + FIHRD
Sbjct: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD 489
Query: 537 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 596
LAARNCLV VKVSDFGM RYVLDDQY SS G KFPVKW PEVF+Y ++SSKSDVW
Sbjct: 490 LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW 549
Query: 597 AFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR 656
+FG+LMWEVF+ G+ P++ Y N +VV V++GHRLY+P LAS+ +Y++M CW E PE R
Sbjct: 550 SFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGR 609
Query: 657 PTFQQLLSSIEPLRE 671
P+F+ LL +I+ L E
Sbjct: 610 PSFEDLLRTIDELVE 624
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 565 bits (1456), Expect = e-161
Identities = 302/674 (44%), Positives = 413/674 (61%), Gaps = 60/674 (8%)
Query: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
M+ +LEE L+K+SQQK++ SP+N+K R FVLTK +L+Y+E K+ + KGSIE+ +I
Sbjct: 1 MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60
Query: 61 RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY 120
+CVE V + P +YPFQ+V+ + LLYV+A + ESR +W+ AL++E R N L+ KY
Sbjct: 61 KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY 120
Query: 121 HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL 180
H F++DGK+ CC Q K A GC ++ N K +P P+ +
Sbjct: 121 HPNFWMDGKWRCCSQLEKLATGCAQYDP------TKNASKKPLPPTPEDNRR-------- 166
Query: 181 KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF 240
+ P + +A YD Y +N + + N + +
Sbjct: 167 PLWEPEETVVIALYD--------------------YQTNDPQELALRRNEEYCLLDSSEI 206
Query: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN 300
WW+V+ V SS E++ N NL+ Y+W+ +
Sbjct: 207 -HWWRVQDRNGHEGY--VPSSYLVEKSPN--------------------NLETYEWYNKS 243
Query: 301 ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAV-NDKKGTVKHYHVHTNAEN-- 357
ISR ++E+LL GKEGAFMVR+S G YTVS+F+KAV ++ +KHYH+ +N
Sbjct: 244 ISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPK 303
Query: 358 KLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEI 417
+ Y+AE Y FDSIP LI+YHQHN G++TRLR+PV K P + L G W + E+
Sbjct: 304 RYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSEL 363
Query: 418 TLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYG 477
T ++E+GSGQFG+V LG W + VA+K I+EG+MSE++F +EA+ MMKLSHPKLV+ YG
Sbjct: 364 TFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYG 423
Query: 478 VCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
VC ++ PI +V E++ +GCL +YLR+ LL MC DVCEGMA+LE IHRDL
Sbjct: 424 VCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDL 483
Query: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
AARNCLV + +KVSDFGMTR+VLDDQY SS GTKFPVKW++PEVF + +YSSKSDVW+
Sbjct: 484 AARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWS 543
Query: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
FG+LMWEVFS GK PY+ NS+VV +S G RLY+P LAS +YQIM CW E PE RP
Sbjct: 544 FGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRP 603
Query: 658 TFQQLLSSIEPLRE 671
F +LL + + E
Sbjct: 604 AFSRLLRQLAEIAE 617
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 470 bits (1209), Expect = e-132
Identities = 238/498 (47%), Positives = 318/498 (63%), Gaps = 39/498 (7%)
Query: 191 LAQYDNESKKNYGSQ--------PPSSSTSLAQYDSNSKKIYGSQPN--FNMQYIPREDF 240
L+Q N+ + N G PP + +A+ K +Y P N+ E++
Sbjct: 50 LSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEY 109
Query: 241 -------PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDD 293
P WW+ R +E + SN N KI+ NL+
Sbjct: 110 LILEKYNPHWWKAR---DRLGNEGLIPSNYVTEN------KIT-------------NLEI 147
Query: 294 YDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHT 353
Y+W+ NI+R+Q+E LLRQ+ KEGAF+VR+S +G YT+S+F A + +KHY +
Sbjct: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKK 207
Query: 354 NAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELK 413
N + Y+AE + F SIP+LI YHQHN+AG++TRLR+PV + +P + WE+
Sbjct: 208 NDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEID 267
Query: 414 REEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLV 473
E+ +KE+GSGQFGVV LG+W+ VA+K I EGSMSE++F +EA+ MMKLSH KLV
Sbjct: 268 PSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLV 327
Query: 474 KFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFI 533
+ YGVC + P+YIVTE++ NGCLLNYLR + L LL +C D+CEGM +LE + +I
Sbjct: 328 QLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYI 387
Query: 534 HRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKS 593
HRDLAARNCLV VK+SDFGMTRYVLDD+YVSS G KFP+KWS PEVF + KYSSKS
Sbjct: 388 HRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKS 447
Query: 594 DVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELP 653
DVW+FG+LMWEVF+ GK P++ N QVV +S+G RLYRPHLA +IY++MYSCWHE P
Sbjct: 448 DVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKP 507
Query: 654 EKRPTFQQLLSSIEPLRE 671
E RPTF +LL ++ + E
Sbjct: 508 EGRPTFAELLRAVTEIAE 525
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 293 bits (751), Expect = 3e-79
Identities = 152/383 (39%), Positives = 232/383 (60%), Gaps = 10/383 (2%)
Query: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKH 348
+L+ + W+ G +SR+ +E LL G G+F+VR S S G ++SL +G V H
Sbjct: 121 SLEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL------RYEGRVYH 173
Query: 349 YHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNG 408
Y ++T ++ KLY++ F+++ +L+H+H + G+IT L +P + VS
Sbjct: 174 YRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYD 233
Query: 409 IWELKREEITLLKELGSGQFGVVQLGKWKG-QYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE++R +IT+ +LG GQ+G V G WK VAVK +KE +M +EF +EA M ++
Sbjct: 234 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 293
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
HP LV+ GVC++E P YI+TE+++ G LL+YLR + + + LL M + M +
Sbjct: 294 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 353
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
LE FIHRDLAARNCLV + VKV+DFG++R + D Y + G KFP+KW+APE Y
Sbjct: 354 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 413
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMY 646
K+S KSDVWAFG+L+WE+ + G PY D SQV + + +R+ RP + +Y++M
Sbjct: 414 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 473
Query: 647 SCWHELPEKRPTFQQLLSSIEPL 669
+CW P RP+F ++ + E +
Sbjct: 474 ACWQWNPSDRPSFAEIHQAFETM 496
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 293 bits (751), Expect = 3e-79
Identities = 152/383 (39%), Positives = 232/383 (60%), Gaps = 10/383 (2%)
Query: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKH 348
+L+ + W+ G +SR+ +E LL G G+F+VR S S G ++SL +G V H
Sbjct: 140 SLEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL------RYEGRVYH 192
Query: 349 YHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNG 408
Y ++T ++ KLY++ F+++ +L+H+H + G+IT L +P + VS
Sbjct: 193 YRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYD 252
Query: 409 IWELKREEITLLKELGSGQFGVVQLGKWKG-QYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE++R +IT+ +LG GQ+G V G WK VAVK +KE +M +EF +EA M ++
Sbjct: 253 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 312
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
HP LV+ GVC++E P YI+TE+++ G LL+YLR + + + LL M + M +
Sbjct: 313 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 372
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
LE FIHRDLAARNCLV + VKV+DFG++R + D Y + G KFP+KW+APE Y
Sbjct: 373 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 432
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMY 646
K+S KSDVWAFG+L+WE+ + G PY D SQV + + +R+ RP + +Y++M
Sbjct: 433 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 492
Query: 647 SCWHELPEKRPTFQQLLSSIEPL 669
+CW P RP+F ++ + E +
Sbjct: 493 ACWQWNPSDRPSFAEIHQAFETM 515
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 287 bits (735), Expect = 2e-77
Identities = 168/477 (35%), Positives = 256/477 (53%), Gaps = 46/477 (9%)
Query: 203 GSQPPSSST------SLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSE 256
GS PP+S +L Y+ + G + ++ + E +WW+ + L +
Sbjct: 53 GSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGF 110
Query: 257 DVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSE-QLLRQKGK 315
I + F ++S E E WF N+SR +E QLL
Sbjct: 111 ------------------IPFNFVAKANSLEPE-----PWFFKNLSRKDAERQLLAPGNT 147
Query: 316 EGAFMVRNSSQVGMYTVSLFSKAVND----KKGTVKHYHVHTNAENKLYLAENYCFDSIP 371
G+F++R S T FS +V D + VKHY + Y++ F +
Sbjct: 148 HGSFLIRESES----TAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLH 203
Query: 372 KLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVV 431
+L+ ++ + S G+ TRL P T+ + P WE+ RE + L++ LG+GQFG V
Sbjct: 204 ELVRHYTNASDGLCTRLSRPCQTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEV 259
Query: 432 QLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEY 491
+G + G VAVK +K+GSMS D F EA M +L H +LV+ Y V ++E PIYI+TEY
Sbjct: 260 WMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEY 318
Query: 492 ISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCV 550
+ NG L+++L++ G L ++LL+M + EGMAF+E +IHRDL A N LV L
Sbjct: 319 MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC 378
Query: 551 KVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGK 610
K++DFG+ R + D++Y + G KFP+KW+APE +Y ++ KSDVW+FGIL+ E+ + G+
Sbjct: 379 KIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR 438
Query: 611 QPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIE 667
PY N +V+ + +G+R+ RP + +YQ+M CW E PE RPTF L S +E
Sbjct: 439 IPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 287 bits (735), Expect = 2e-77
Identities = 168/477 (35%), Positives = 256/477 (53%), Gaps = 46/477 (9%)
Query: 203 GSQPPSSST------SLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSE 256
GS PP+S +L Y+ + G + ++ + E +WW+ + L +
Sbjct: 53 GSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGF 110
Query: 257 DVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSE-QLLRQKGK 315
I + F ++S E E WF N+SR +E QLL
Sbjct: 111 ------------------IPFNFVAKANSLEPE-----PWFFKNLSRKDAERQLLAPGNT 147
Query: 316 EGAFMVRNSSQVGMYTVSLFSKAVND----KKGTVKHYHVHTNAENKLYLAENYCFDSIP 371
G+F++R S T FS +V D + VKHY + Y++ F +
Sbjct: 148 HGSFLIRESES----TAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLH 203
Query: 372 KLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVV 431
+L+ ++ + S G+ TRL P T+ + P WE+ RE + L++ LG+GQFG V
Sbjct: 204 ELVRHYTNASDGLCTRLSRPCQTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEV 259
Query: 432 QLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEY 491
+G + G VAVK +K+GSMS D F EA M +L H +LV+ Y V ++E PIYI+TEY
Sbjct: 260 WMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEY 318
Query: 492 ISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCV 550
+ NG L+++L++ G L ++LL+M + EGMAF+E +IHRDL A N LV L
Sbjct: 319 MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC 378
Query: 551 KVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGK 610
K++DFG+ R + D++Y + G KFP+KW+APE +Y ++ KSDVW+FGIL+ E+ + G+
Sbjct: 379 KIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR 438
Query: 611 QPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIE 667
PY N +V+ + +G+R+ RP + +YQ+M CW E PE RPTF L S +E
Sbjct: 439 IPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 285 bits (729), Expect = 1e-76
Identities = 152/383 (39%), Positives = 226/383 (59%), Gaps = 10/383 (2%)
Query: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKH 348
+L+ + W+ G +SRS +E LL G+F+VR S S G ++SL +G V H
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISL------RYEGRVYH 204
Query: 349 YHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNG 408
Y ++T A+ K+Y+ F ++ +L+H+H + G++T L +P VS +
Sbjct: 205 YRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHD 264
Query: 409 IWELKREEITLLKELGSGQFGVVQLGKWKG-QYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE++R +IT+ +LG GQ+G V +G WK VAVK +KE +M +EF +EA M ++
Sbjct: 265 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 324
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
HP LV+ GVC+ E P YIVTEY+ G LL+YLR + + + LL M + M +
Sbjct: 325 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 384
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
LE FIHRDLAARNCLV + VKV+DFG++R + D Y + G KFP+KW+APE Y
Sbjct: 385 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 444
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMY 646
+S KSDVWAFG+L+WE+ + G PY D SQV + +G+R+ +P +Y++M
Sbjct: 445 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 504
Query: 647 SCWHELPEKRPTFQQLLSSIEPL 669
+CW P RP+F + + E +
Sbjct: 505 ACWKWSPADRPSFAETHQAFETM 527
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 285 bits (729), Expect = 1e-76
Identities = 152/383 (39%), Positives = 226/383 (59%), Gaps = 10/383 (2%)
Query: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKH 348
+L+ + W+ G +SRS +E LL G+F+VR S S G ++SL +G V H
Sbjct: 167 SLEKHSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISL------RYEGRVYH 219
Query: 349 YHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNG 408
Y ++T A+ K+Y+ F ++ +L+H+H + G++T L +P VS +
Sbjct: 220 YRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHD 279
Query: 409 IWELKREEITLLKELGSGQFGVVQLGKWKG-QYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE++R +IT+ +LG GQ+G V +G WK VAVK +KE +M +EF +EA M ++
Sbjct: 280 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 339
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
HP LV+ GVC+ E P YIVTEY+ G LL+YLR + + + LL M + M +
Sbjct: 340 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 399
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
LE FIHRDLAARNCLV + VKV+DFG++R + D Y + G KFP+KW+APE Y
Sbjct: 400 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 459
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMY 646
+S KSDVWAFG+L+WE+ + G PY D SQV + +G+R+ +P +Y++M
Sbjct: 460 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 519
Query: 647 SCWHELPEKRPTFQQLLSSIEPL 669
+CW P RP+F + + E +
Sbjct: 520 ACWKWSPADRPSFAETHQAFETM 542
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 285 bits (729), Expect = 1e-76
Identities = 152/383 (39%), Positives = 226/383 (59%), Gaps = 10/383 (2%)
Query: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKH 348
+L+ + W+ G +SRS +E LL G+F+VR S S G ++SL +G V H
Sbjct: 146 SLEKHSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISL------RYEGRVYH 198
Query: 349 YHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNG 408
Y ++T A+ K+Y+ F ++ +L+H+H + G++T L +P VS +
Sbjct: 199 YRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHD 258
Query: 409 IWELKREEITLLKELGSGQFGVVQLGKWKG-QYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE++R +IT+ +LG GQ+G V +G WK VAVK +KE +M +EF +EA M ++
Sbjct: 259 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 318
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
HP LV+ GVC+ E P YIVTEY+ G LL+YLR + + + LL M + M +
Sbjct: 319 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 378
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
LE FIHRDLAARNCLV + VKV+DFG++R + D Y + G KFP+KW+APE Y
Sbjct: 379 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 438
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMY 646
+S KSDVWAFG+L+WE+ + G PY D SQV + +G+R+ +P +Y++M
Sbjct: 439 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 498
Query: 647 SCWHELPEKRPTFQQLLSSIEPL 669
+CW P RP+F + + E +
Sbjct: 499 ACWKWSPADRPSFAETHQAFETM 521
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 285 bits (729), Expect = 1e-76
Identities = 152/383 (39%), Positives = 226/383 (59%), Gaps = 10/383 (2%)
Query: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKH 348
+L+ + W+ G +SRS +E LL G+F+VR S S G ++SL +G V H
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISL------RYEGRVYH 204
Query: 349 YHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNG 408
Y ++T A+ K+Y+ F ++ +L+H+H + G++T L +P VS +
Sbjct: 205 YRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHD 264
Query: 409 IWELKREEITLLKELGSGQFGVVQLGKWKG-QYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE++R +IT+ +LG GQ+G V +G WK VAVK +KE +M +EF +EA M ++
Sbjct: 265 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 324
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
HP LV+ GVC+ E P YIVTEY+ G LL+YLR + + + LL M + M +
Sbjct: 325 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 384
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
LE FIHRDLAARNCLV + VKV+DFG++R + D Y + G KFP+KW+APE Y
Sbjct: 385 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 444
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMY 646
+S KSDVWAFG+L+WE+ + G PY D SQV + +G+R+ +P +Y++M
Sbjct: 445 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 504
Query: 647 SCWHELPEKRPTFQQLLSSIEPL 669
+CW P RP+F + + E +
Sbjct: 505 ACWKWSPADRPSFAETHQAFETM 527
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 285 bits (729), Expect = 1e-76
Identities = 152/383 (39%), Positives = 226/383 (59%), Gaps = 10/383 (2%)
Query: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKH 348
+L+ + W+ G +SRS +E LL G+F+VR S S G ++SL +G V H
Sbjct: 131 SLEKHSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISL------RYEGRVYH 183
Query: 349 YHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNG 408
Y ++T A+ K+Y+ F ++ +L+H+H + G++T L +P VS +
Sbjct: 184 YRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHD 243
Query: 409 IWELKREEITLLKELGSGQFGVVQLGKWKG-QYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE++R +IT+ +LG GQ+G V +G WK VAVK +KE +M +EF +EA M ++
Sbjct: 244 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 303
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
HP LV+ GVC+ E P YIVTEY+ G LL+YLR + + + LL M + M +
Sbjct: 304 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 363
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
LE FIHRDLAARNCLV + VKV+DFG++R + D Y + G KFP+KW+APE Y
Sbjct: 364 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 423
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMY 646
+S KSDVWAFG+L+WE+ + G PY D SQV + +G+R+ +P +Y++M
Sbjct: 424 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 483
Query: 647 SCWHELPEKRPTFQQLLSSIEPL 669
+CW P RP+F + + E +
Sbjct: 484 ACWKWSPADRPSFAETHQAFETM 506
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 282 bits (722), Expect = 6e-76
Identities = 152/430 (35%), Positives = 243/430 (56%), Gaps = 30/430 (6%)
Query: 242 DWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNI 301
DWW+ R L + + + S+ +++ +W+ G +
Sbjct: 118 DWWEARSLTTGETG-----------------------YIPSNYVAPVDSIQAEEWYFGKL 154
Query: 302 SRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGT-VKHYHVHTNAENK 358
R +E QLL G F++R S G Y++S+ + +D KG VKHY +
Sbjct: 155 GRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI--RDWDDMKGDHVKHYKIRKLDNGG 212
Query: 359 LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEIT 418
Y+ F+++ +L+ ++ +AG+ RL P ++ D +WE+ RE +
Sbjct: 213 YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQ 272
Query: 419 LLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGV 478
L+K LG+GQFG V +G W G VA+K +K G+MS + F +EAQ M KL H KLV+ Y V
Sbjct: 273 LIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV 332
Query: 479 CSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
S+E PIYIVTEY++ G LL++L+ G+ L+ L++M V GMA++E +IHRDL
Sbjct: 333 VSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL 391
Query: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
+ N LV L K++DFG+ R + D++Y + G KFP+KW+APE Y +++ KSDVW+
Sbjct: 392 RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 451
Query: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
FGIL+ E+ + G+ PY +N +V+ +V +G+R+ P +++++M CW + PE+RP
Sbjct: 452 FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERP 511
Query: 658 TFQQLLSSIE 667
TF+ L S +E
Sbjct: 512 TFEYLQSFLE 521
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 279 bits (713), Expect = 7e-75
Identities = 154/401 (38%), Positives = 234/401 (58%), Gaps = 8/401 (1%)
Query: 270 HTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLL-RQKGKEGAFMVRNSSQV- 327
H+ S + S+ +++ +W+ G I+R +SE+LL + G F+VR S
Sbjct: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
Query: 328 GMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITR 387
G Y +S+ S N K VKHY + Y+ F+S+ +L+ Y+ ++ G+ R
Sbjct: 185 GAYCLSV-SDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHR 243
Query: 388 LRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMI 447
L T P + L WE+ RE + L +LG G FG V +G W G VA+K +
Sbjct: 244 LTTVCPTSK---PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
Query: 448 KEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GK 506
K G+MS + F QEAQ M KL H KLV+ Y V S+E PIYIVTEY+S G LL++L+ GK
Sbjct: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGK 359
Query: 507 GLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQY 566
L QL++M + GMA++E ++HRDL A N LV +L KV+DFG+ R + D++Y
Sbjct: 360 YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY 419
Query: 567 VSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVS 626
+ G KFP+KW+APE Y +++ KSDVW+FGIL+ E+ + G+ PY N +V+ +V
Sbjct: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479
Query: 627 QGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIE 667
+G+R+ P ++++ +M CW + PE+RPTF+ L + +E
Sbjct: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 279 bits (713), Expect = 7e-75
Identities = 154/401 (38%), Positives = 234/401 (58%), Gaps = 8/401 (1%)
Query: 270 HTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLL-RQKGKEGAFMVRNSSQV- 327
H+ S + S+ +++ +W+ G I+R +SE+LL + G F+VR S
Sbjct: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
Query: 328 GMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITR 387
G Y +S+ S N K VKHY + Y+ F+S+ +L+ Y+ ++ G+ R
Sbjct: 185 GAYCLSV-SDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHR 243
Query: 388 LRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMI 447
L T P + L WE+ RE + L +LG G FG V +G W G VA+K +
Sbjct: 244 LTTVCPTSK---PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
Query: 448 KEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GK 506
K G+MS + F QEAQ M KL H KLV+ Y V S+E PIYIVTEY+S G LL++L+ GK
Sbjct: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGK 359
Query: 507 GLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQY 566
L QL++M + GMA++E ++HRDL A N LV +L KV+DFG+ R + D++Y
Sbjct: 360 YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY 419
Query: 567 VSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVS 626
+ G KFP+KW+APE Y +++ KSDVW+FGIL+ E+ + G+ PY N +V+ +V
Sbjct: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479
Query: 627 QGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIE 667
+G+R+ P ++++ +M CW + PE+RPTF+ L + +E
Sbjct: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 278 bits (710), Expect = 2e-74
Identities = 159/394 (40%), Positives = 221/394 (56%), Gaps = 13/394 (3%)
Query: 287 EEENLDDYDWFAGNISRSQSE-QLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKG 344
E+ +L WF G I RS +E QLL + K G+F++R S SQ G +++S+ AV
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAV----- 161
Query: 345 TVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVS 404
VKHY + E +L F ++ + + ++ S G+ +L P P +S
Sbjct: 162 -VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLS 220
Query: 405 LGN-GIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQT 463
WE+ R I LLK LGSGQFG V G W VAVK +K GSM ++F +EAQ
Sbjct: 221 YKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQI 280
Query: 464 MMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVCE 522
M L HPKL++ Y VC+ E PIYI+TE + +G L YL++ G + +Q ++M V
Sbjct: 281 MKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVAS 340
Query: 523 GMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVL---DDQYVSSVGTKFPVKWS 579
GMA+LES +IHRDLAARN LV KV+DFG+ R +D Y S K PVKW+
Sbjct: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400
Query: 580 APEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASD 639
APE K+S KSDVW+FGIL++E+ + GK PY +QV+ ++Q +RL +P
Sbjct: 401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQ 460
Query: 640 TIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKD 673
Y IM CW+ P++RPTF+ L +E E D
Sbjct: 461 QFYNIMLECWNAEPKERPTFETLRWKLEDYFETD 494
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 274 bits (701), Expect = 2e-73
Identities = 146/382 (38%), Positives = 224/382 (58%), Gaps = 10/382 (2%)
Query: 289 ENLDDYDWFAGNISRSQSE-QLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVK 347
E+L+ WF + R ++E QLL K G+F++R S + SL K V + +K
Sbjct: 117 ESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRES-ETNKGAFSLSVKDVTTQGELIK 175
Query: 348 HYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGN 407
HY + E Y++ F S+ L+ ++ G+ RL P A + P
Sbjct: 176 HYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNP----WAQ 231
Query: 408 GIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKL 467
WE+ R+ + L+++LGSGQFG V +G +K VA+K +KEG+MS + F EA M L
Sbjct: 232 DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKAL 291
Query: 468 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAF 526
H +LV+ Y V +KE PIYIVTEY++ GCLL++L++ G L +L++M + EGMA+
Sbjct: 292 QHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAY 350
Query: 527 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY 586
+E IHRDL A N LV LC K++DFG+ R ++D +Y + G KFP+KW+APE H+
Sbjct: 351 IERMNSIHRDLRAANILVSEALCCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHF 409
Query: 587 FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQ-IM 645
++ K+DVW+FG+L+ EV + G+ PY N +V+ + +G+R+ RP +Y+ ++
Sbjct: 410 GVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVI 469
Query: 646 YSCWHELPEKRPTFQQLLSSIE 667
CW PE+RPTF+ L S +E
Sbjct: 470 AECWRSRPEERPTFEFLQSVLE 491
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 274 bits (700), Expect = 2e-73
Identities = 153/439 (34%), Positives = 244/439 (55%), Gaps = 34/439 (7%)
Query: 233 QYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLD 292
Q + E+ +WW+ R L ++ E SN R ++L+
Sbjct: 104 QMVVLEESGEWWKARSL--ATRKEGYIPSNYVAR---------------------VDSLE 140
Query: 293 DYDWFAGNISRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKG-TVKHY 349
+WF ISR +E QLL G+FM+R+S G Y++S+ + + ++G TVKHY
Sbjct: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSV--RDYDPRQGDTVKHY 198
Query: 350 HVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGI 409
+ T Y++ F ++ +L+ +++ + G+ +L P + + P
Sbjct: 199 KIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWE----KDA 254
Query: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH 469
WE+ RE + L K+LG+GQFG V + + VAVK +K GSMS + F EA M L H
Sbjct: 255 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQH 314
Query: 470 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEP-SQLLEMCYDVCEGMAFLE 528
KLVK + V +KE PIYI+TE+++ G LL++L+S +P +L++ + EGMAF+E
Sbjct: 315 DKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 373
Query: 529 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFK 588
+IHRDL A N LV L K++DFG+ R + D++Y + G KFP+KW+APE ++
Sbjct: 374 QRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGS 433
Query: 589 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSC 648
++ KSDVW+FGIL+ E+ + G+ PY N +V+ + +G+R+ RP + +Y IM C
Sbjct: 434 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRC 493
Query: 649 WHELPEKRPTFQQLLSSIE 667
W PE+RPTF+ + S ++
Sbjct: 494 WKNRPEERPTFEYIQSVLD 512
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 273 bits (697), Expect = 5e-73
Identities = 151/384 (39%), Positives = 226/384 (58%), Gaps = 16/384 (4%)
Query: 291 LDDYDWFAGNISRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSL--FSKAVNDKKGTV 346
L+ +WF +I+R +E QLL GAF++R S + G +++S+ F D +
Sbjct: 103 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGD---VI 159
Query: 347 KHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHP-VSTKANKVPDSVSL 405
KHY + + Y++ F I +I ++Q + G+ RL +S K K D +
Sbjct: 160 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDA- 218
Query: 406 GNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMM 465
WE+ RE I L+K LG+GQFG V +G + VAVK +K G+MS F +EA M
Sbjct: 219 ----WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMK 274
Query: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH--GKGLEPSQLLEMCYDVCEG 523
L H KLV+ Y V ++E PIYI+TEY++ G LL++L+S GK L P +L++ + EG
Sbjct: 275 TLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP-KLIDFSAQIAEG 333
Query: 524 MAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV 583
MA++E +IHRDL A N LV L K++DFG+ R + D++Y + G KFP+KW+APE
Sbjct: 334 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 393
Query: 584 FHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQ 643
++ ++ KSDVW+FGIL++E+ + GK PY N+ V+ +SQG+R+ R D +Y
Sbjct: 394 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYD 453
Query: 644 IMYSCWHELPEKRPTFQQLLSSIE 667
IM CW E E+RPTF L S ++
Sbjct: 454 IMKMCWKEKAEERPTFDYLQSVLD 477
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 273 bits (697), Expect = 5e-73
Identities = 151/384 (39%), Positives = 226/384 (58%), Gaps = 16/384 (4%)
Query: 291 LDDYDWFAGNISRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSL--FSKAVNDKKGTV 346
L+ +WF +I+R +E QLL GAF++R S + G +++S+ F D +
Sbjct: 124 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGD---VI 180
Query: 347 KHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHP-VSTKANKVPDSVSL 405
KHY + + Y++ F I +I ++Q + G+ RL +S K K D +
Sbjct: 181 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDA- 239
Query: 406 GNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMM 465
WE+ RE I L+K LG+GQFG V +G + VAVK +K G+MS F +EA M
Sbjct: 240 ----WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMK 295
Query: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH--GKGLEPSQLLEMCYDVCEG 523
L H KLV+ Y V ++E PIYI+TEY++ G LL++L+S GK L P +L++ + EG
Sbjct: 296 TLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP-KLIDFSAQIAEG 354
Query: 524 MAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV 583
MA++E +IHRDL A N LV L K++DFG+ R + D++Y + G KFP+KW+APE
Sbjct: 355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 414
Query: 584 FHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQ 643
++ ++ KSDVW+FGIL++E+ + GK PY N+ V+ +SQG+R+ R D +Y
Sbjct: 415 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYD 474
Query: 644 IMYSCWHELPEKRPTFQQLLSSIE 667
IM CW E E+RPTF L S ++
Sbjct: 475 IMKMCWKEKAEERPTFDYLQSVLD 498
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 270 bits (689), Expect = 4e-72
Identities = 150/431 (34%), Positives = 243/431 (56%), Gaps = 35/431 (8%)
Query: 242 DWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNI 301
DWW+ R + + + + S+ +++ +W+ G +
Sbjct: 127 DWWEARSIATGKNG-----------------------YIPSNYVAPADSIQAEEWYFGKM 163
Query: 302 SRSQSEQLLRQKGKE-GAFMVRNSSQV-GMYTVSLFSKAVNDKKG-TVKHYHVHTNAENK 358
R +E+LL G + G F+VR S G Y++S+ + ++ +G VKHY +
Sbjct: 164 GRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSI--RDWDEIRGDNVKHYKIRKLDNGG 221
Query: 359 LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKV-PDSVSLGNGIWELKREEI 417
Y+ FD++ KL+ ++ ++ G+ H ++T V P + L WE+ RE +
Sbjct: 222 YYITTRAQFDTLQKLVKHYTEHADGLC----HKLTTVCPTVKPQTQGLAKDAWEIPRESL 277
Query: 418 TLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYG 477
L +LG G FG V +G W G VA+K +K G+M + F QEAQ M KL H KLV Y
Sbjct: 278 RLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYA 337
Query: 478 VCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRD 536
V S+E PIYIVTE++S G LL++L+ GK L+ QL++M + +GMA++E +IHRD
Sbjct: 338 VVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRD 396
Query: 537 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 596
L A N LV +L K++DFG+ R + D++Y + G KFP+KW+APE Y +++ KSDVW
Sbjct: 397 LRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 456
Query: 597 AFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR 656
+FGIL E+ + G+ PY N +V+ +V +G+R+ P ++++++M CW + P++R
Sbjct: 457 SFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDER 516
Query: 657 PTFQQLLSSIE 667
PTF+ + S +E
Sbjct: 517 PTFEYIQSFLE 527
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 267 bits (683), Expect = 2e-71
Identities = 149/430 (34%), Positives = 237/430 (55%), Gaps = 33/430 (7%)
Query: 242 DWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNI 301
DWW+ R L + + + S+ +++ +W+ G +
Sbjct: 118 DWWEARSLTTGETG-----------------------YIPSNYVAPVDSIQAEEWYFGKL 154
Query: 302 SRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGT-VKHYHVHTNAENK 358
R +E QLL G F++R S G Y++S+ + +D KG VKHY +
Sbjct: 155 GRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI--RDWDDMKGDHVKHYKIRKLDNGG 212
Query: 359 LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEIT 418
Y+ F+++ +L+ ++ + G+ L S+ P + L WE+ R +
Sbjct: 213 YYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT---PQTSGLAKDAWEVARRSLC 269
Query: 419 LLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGV 478
L K+LG G F V LG W G VA+K +K G+MS + F +EAQ M KL H KLV+ Y V
Sbjct: 270 LEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV 329
Query: 479 CSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
S+E PIYIVTEY++ G LL++L+ G+ L+ L++M V GMA++E +IHRDL
Sbjct: 330 VSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL 388
Query: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
+ N LV L K++DFG+ R + D++Y + G KFP+KW+APE Y +++ KSDVW+
Sbjct: 389 RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 448
Query: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
FGIL+ E+ + G+ PY +N +V+ +V +G+R+ P +++++M CW + PE+RP
Sbjct: 449 FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERP 508
Query: 658 TFQQLLSSIE 667
TF+ L S +E
Sbjct: 509 TFEYLQSFLE 518
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 267 bits (683), Expect = 2e-71
Identities = 160/430 (37%), Positives = 236/430 (54%), Gaps = 33/430 (7%)
Query: 242 DWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNI 301
DWW+ R L SS SN + P S EE W+ G I
Sbjct: 113 DWWEARSL--SSGKTGCIPSN--------------YVAPVDSIQAEE-------WYFGKI 149
Query: 302 SRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGT-VKHYHVHTNAENK 358
R +E QLL +GAF++R S G Y++S+ + + +G VKHY +
Sbjct: 150 GRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHVKHYKIRKLDMGG 207
Query: 359 LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEIT 418
Y+ F+S+ +L+ ++ + G+ L P + P ++ L WE+ R IT
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWEISRSSIT 264
Query: 419 LLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGV 478
L + LG+G FG V LG W G VAVK +K G+MS F +EAQ M L H KLV+ Y V
Sbjct: 265 LERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAV 324
Query: 479 CSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
S+E PIYIVTE++ +G LL++L++ G+ L QL++M V EGMA++E +IHRDL
Sbjct: 325 VSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDL 383
Query: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
A N LV L K++DFG+ R + DD+Y G+KFP+KW+APE + +++ KSDVW+
Sbjct: 384 RAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWS 443
Query: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
FGIL+ E+ + G+ PY + +V+ +V QG+ + P ++Y+ M W PE+RP
Sbjct: 444 FGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERP 503
Query: 658 TFQQLLSSIE 667
TF+ L S +E
Sbjct: 504 TFEYLQSFLE 513
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 267 bits (683), Expect = 2e-71
Identities = 160/430 (37%), Positives = 236/430 (54%), Gaps = 33/430 (7%)
Query: 242 DWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNI 301
DWW+ R L SS SN + P S EE W+ G I
Sbjct: 113 DWWEARSL--SSGKTGCIPSN--------------YVAPVDSIQAEE-------WYFGKI 149
Query: 302 SRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGT-VKHYHVHTNAENK 358
R +E QLL +GAF++R S G Y++S+ + + +G VKHY +
Sbjct: 150 GRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHVKHYKIRKLDMGG 207
Query: 359 LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEIT 418
Y+ F+S+ +L+ ++ + G+ L P + P ++ L WE+ R IT
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWEISRSSIT 264
Query: 419 LLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGV 478
L + LG+G FG V LG W G VAVK +K G+MS F +EAQ M L H KLV+ Y V
Sbjct: 265 LERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAV 324
Query: 479 CSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
S+E PIYIVTE++ +G LL++L++ G+ L QL++M V EGMA++E +IHRDL
Sbjct: 325 VSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDL 383
Query: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
A N LV L K++DFG+ R + DD+Y G+KFP+KW+APE + +++ KSDVW+
Sbjct: 384 RAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWS 443
Query: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
FGIL+ E+ + G+ PY + +V+ +V QG+ + P ++Y+ M W PE+RP
Sbjct: 444 FGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERP 503
Query: 658 TFQQLLSSIE 667
TF+ L S +E
Sbjct: 504 TFEYLQSFLE 513
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 267 bits (683), Expect = 2e-71
Identities = 160/430 (37%), Positives = 236/430 (54%), Gaps = 33/430 (7%)
Query: 242 DWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNI 301
DWW+ R L SS SN + P S EE W+ G I
Sbjct: 113 DWWEARSL--SSGKTGCIPSN--------------YVAPVDSIQAEE-------WYFGKI 149
Query: 302 SRSQSE-QLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGT-VKHYHVHTNAENK 358
R +E QLL +GAF++R S G Y++S+ + + +G VKHY +
Sbjct: 150 GRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHVKHYKIRKLDMGG 207
Query: 359 LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEIT 418
Y+ F+S+ +L+ ++ + G+ L P + P ++ L WE+ R IT
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWEISRSSIT 264
Query: 419 LLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGV 478
L + LG+G FG V LG W G VAVK +K G+MS F +EAQ M L H KLV+ Y V
Sbjct: 265 LERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAV 324
Query: 479 CSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
S+E PIYIVTE++ +G LL++L++ G+ L QL++M V EGMA++E +IHRDL
Sbjct: 325 VSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDL 383
Query: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
A N LV L K++DFG+ R + DD+Y G+KFP+KW+APE + +++ KSDVW+
Sbjct: 384 RAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWS 443
Query: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
FGIL+ E+ + G+ PY + +V+ +V QG+ + P ++Y+ M W PE+RP
Sbjct: 444 FGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERP 503
Query: 658 TFQQLLSSIE 667
TF+ L S +E
Sbjct: 504 TFEYLQSFLE 513
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 258 bits (659), Expect = 1e-68
Identities = 145/384 (37%), Positives = 214/384 (55%), Gaps = 16/384 (4%)
Query: 289 ENLDDYDWFAGNISRSQSEQLLRQKGKE-GAFMVRNS-SQVGMYTVSLFSKAVNDKKGTV 346
E L D W+ +SR+Q++QLL E GAF++R S S +G Y++S+ ++A V
Sbjct: 113 ETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQA------KV 166
Query: 347 KHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLG 406
HY V A+ LYL + F + +L+ Y++ N + L P + D
Sbjct: 167 CHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQD----- 221
Query: 407 NGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMK 466
+WE E L ++LG G FG V G W G VA+K+IK +M + +E QT+
Sbjct: 222 --VWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKG 279
Query: 467 LSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS-HGKGLEPSQLLEMCYDVCEGMA 525
L H +L++ + VCS P+YIVTE + G L +L + G+ L LL V EGM+
Sbjct: 280 LRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMS 339
Query: 526 FLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFH 585
+LE + +HRDLAARN LVD L KV+DFG+ R + DD Y S +K PVKW+APE +
Sbjct: 340 YLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAAN 399
Query: 586 YFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIM 645
Y +S KSDVW+FG+L+ EVF+ G+ PY+ N + + ++ +G+RL RP +Y +M
Sbjct: 400 YRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLM 459
Query: 646 YSCWHELPEKRPTFQQLLSSIEPL 669
CW PE+RP+F L + +
Sbjct: 460 LECWRSSPEERPSFATLREKLHAI 483
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 251 bits (640), Expect = 2e-66
Identities = 148/383 (38%), Positives = 220/383 (57%), Gaps = 18/383 (4%)
Query: 296 WFAGNISRSQSEQLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGTVKHYHVHTN 354
WF G I+R Q+E+LL + G F+VR S+ G YT+ + G V+HY + +
Sbjct: 82 WFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSCD------GKVEHYRIMYH 134
Query: 355 AENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKR 414
A +KL + E F+++ +L+ ++ ++ G+ TRL P + +G W L
Sbjct: 135 A-SKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSG-WALNM 192
Query: 415 EEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVK 474
+E+ LL+ +G G+FG V LG ++G VAVK IK + ++ F EA M +L H LV+
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQLRHSNLVQ 250
Query: 475 FYGVCSKEYP-IYIVTEYISNGCLLNYLRSHGKG-LEPSQLLEMCYDVCEGMAFLESHQF 532
GV +E +YIVTEY++ G L++YLRS G+ L LL+ DVCE M +LE + F
Sbjct: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310
Query: 533 IHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSK 592
+HRDLAARN LV D KVSDFG+T+ Q K PVKW+APE K+S+K
Sbjct: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFSTK 366
Query: 593 SDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHEL 652
SDVW+FGIL+WE++S G+ PY VV +V +G+++ P +Y++M +CWH
Sbjct: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426
Query: 653 PEKRPTFQQLLSSIEPLREKDKH 675
RP+F QL +E ++ + H
Sbjct: 427 AAMRPSFLQLREQLEHIKTHELH 449
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,846,345
Number of Sequences: 37866
Number of extensions: 1177586
Number of successful extensions: 6286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 598
Number of HSP's successfully gapped in prelim test: 350
Number of HSP's that attempted gapping in prelim test: 4021
Number of HSP's gapped (non-prelim): 1292
length of query: 675
length of database: 18,247,518
effective HSP length: 109
effective length of query: 566
effective length of database: 14,120,124
effective search space: 7991990184
effective search space used: 7991990184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.