Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4502431
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502431 bone morphogenetic protein receptor, type IB
precursor [Homo sapiens]
(502 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 1036 0.0
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 750 0.0
gi|4759226 transforming growth factor, beta receptor I isoform 1... 494 e-140
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 471 e-133
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 464 e-131
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 464 e-131
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 457 e-128
gi|195963412 transforming growth factor, beta receptor I isoform... 451 e-127
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 449 e-126
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 422 e-118
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 420 e-117
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 416 e-116
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 416 e-116
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 357 2e-98
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 310 2e-84
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 240 2e-63
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 230 3e-60
gi|15451916 bone morphogenetic protein receptor type II precurso... 218 1e-56
gi|67782324 transforming growth factor, beta receptor II isoform... 216 5e-56
gi|67782326 transforming growth factor, beta receptor II isoform... 216 5e-56
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 157 3e-38
gi|187475373 c-src tyrosine kinase [Homo sapiens] 100 2e-21
gi|4758078 c-src tyrosine kinase [Homo sapiens] 100 2e-21
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 93 6e-19
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 92 8e-19
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 92 8e-19
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 91 2e-18
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 91 2e-18
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 89 7e-18
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 89 7e-18
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 1036 bits (2680), Expect = 0.0
Identities = 502/502 (100%), Positives = 502/502 (100%)
Query: 1 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 60
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
Sbjct: 1 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 60
Query: 61 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 120
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
Sbjct: 61 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 120
Query: 121 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 180
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
Sbjct: 121 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 180
Query: 181 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 240
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
Sbjct: 181 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 240
Query: 241 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 300
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
Sbjct: 241 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 300
Query: 301 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 360
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
Sbjct: 301 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 360
Query: 361 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 420
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
Sbjct: 361 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 420
Query: 421 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 480
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
Sbjct: 421 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 480
Query: 481 RLTALRVKKTLAKMSESQDIKL 502
RLTALRVKKTLAKMSESQDIKL
Sbjct: 481 RLTALRVKKTLAKMSESQDIKL 502
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 750 bits (1937), Expect = 0.0
Identities = 360/491 (73%), Positives = 415/491 (84%), Gaps = 3/491 (0%)
Query: 14 KKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLG 73
K E+G + AP L+C C HCP+D++NN C T+G+CF +IEEDD G + SGC+
Sbjct: 43 KSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMK 102
Query: 74 LEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVT 133
EGSDFQC+D+P RR+IECC N CN+ L PTLPP+ F DG I LLIS+
Sbjct: 103 YEGSDFQCKDSPKAQLRRTIECC-RTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMA 161
Query: 134 VCSLLLVLII-LFCYFRY-KRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSG 191
VC + +++ FCY Y K +R RY+ LEQDE +IP GESL+DLI+QSQSSGSGSG
Sbjct: 162 VCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSG 221
Query: 192 LPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTV 251
LPLLVQRTIAKQIQMV+Q+GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTV
Sbjct: 222 LPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTV 281
Query: 252 LMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSG 311
LMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYD+LK TLD +++LKLAYS+ G
Sbjct: 282 LMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACG 341
Query: 312 LCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTR 371
LCHLHTEI+ TQGKPAIAHRDLKSKNIL+KKNG+CCIADLGLAVKF SDTNEVD+P NTR
Sbjct: 342 LCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTR 401
Query: 372 VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLV 431
VGTKRYM PEVLDESLN+NHFQ YIMAD+YSFGLI+WE+ARRC++GGIVEEYQLPY+++V
Sbjct: 402 VGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMV 461
Query: 432 PSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 491
PSDPSYEDMRE+VC+K+LRP NRW+SDECLR + KLM+ECWAHNPASRLTALR+KKTL
Sbjct: 462 PSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL 521
Query: 492 AKMSESQDIKL 502
AKM ESQD+K+
Sbjct: 522 AKMVESQDVKI 532
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 494 bits (1272), Expect = e-140
Identities = 261/489 (53%), Positives = 333/489 (68%), Gaps = 15/489 (3%)
Query: 20 STAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGL----- 74
+ A P L+C CH C +D N C TDG CF + E + + S C+
Sbjct: 24 AAALLPGATALQCFCHL-CTKD--NFTCVTDGLCFVSVTETTDKV-IHNSMCIAEIDLIP 79
Query: 75 EGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLIS-VT 133
F C + + CC + + CNK PT +K+ + GP+ A++ V
Sbjct: 80 RDRPFVCAPSSKTGSVTTTYCCNQ-DHCNKIELPTT--VKSSPGL-GPVELAAVIAGPVC 135
Query: 134 VCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLP 193
+ L+L++ C+ R P D +I G +L+DLI +SGSGSGLP
Sbjct: 136 FVCISLMLMVYICHNRTVIHHRVPNEE-DPSLDRPFISEGTTLKDLIYDMTTSGSGSGLP 194
Query: 194 LLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLM 253
LLVQRTIA+ I + + IGKGR+GEVW GKWRGE+VAVK+F + EE SWFRE EIYQTV++
Sbjct: 195 LLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVML 254
Query: 254 RHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLC 313
RHENILGFIAAD K G+WTQL+L++DYHE+GSL+DYL T+ + M+KLA S+ SGL
Sbjct: 255 RHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLA 314
Query: 314 HLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVG 373
HLH EI TQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV+ S T+ +DI PN RVG
Sbjct: 315 HLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVG 374
Query: 374 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPS 433
TKRYM PEVLD+S+N HF+S+ AD+Y+ GL+ WE+ARRC GGI E+YQLPY+DLVPS
Sbjct: 375 TKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPS 434
Query: 434 DPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAK 493
DPS E+MR++VC +KLRP+ PNRW S E LR M K+M ECW N A+RLTALR+KKTL++
Sbjct: 435 DPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQ 494
Query: 494 MSESQDIKL 502
+S+ + IK+
Sbjct: 495 LSQQEGIKM 503
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 471 bits (1211), Expect = e-133
Identities = 248/469 (52%), Positives = 318/469 (67%), Gaps = 16/469 (3%)
Query: 44 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGL-----EGSDFQCRDTPIPHQRRSIECCTE 98
N C TDG C I D G+ C+ G F C + R+ CC
Sbjct: 43 NYTCETDGACMVSIFNLD-GMEHHVRTCIPKVELVPAGKPFYCLSS---EDLRNTHCCYT 98
Query: 99 RNECNK-DLHPTLPPLKNRDFVD--GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQET 155
+ CN+ DL LK + GP+ + I+ V L L++II+F Y ++
Sbjct: 99 -DYCNRIDLRVPSGHLKEPEHPSMWGPVELVGI-IAGPVFLLFLIIIIVFLVINYHQRVY 156
Query: 156 RPRYSIGLEQD--ETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKG 213
R + +E E + ++L+DL+ +SGSGSGLPL VQRT+A+ I + + IGKG
Sbjct: 157 HNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKG 216
Query: 214 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 273
R+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K G+WT
Sbjct: 217 RFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT 276
Query: 274 QLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDL 333
QL+L++DYHE+GSL+DYL T+ + M+KLA S+ SGL HLH EI TQGKP IAHRDL
Sbjct: 277 QLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDL 336
Query: 334 KSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQ 393
KSKNILVKKNG C IADLGLAV+ + T+ +DI PN RVGTKRYM PEVLDE++N HF
Sbjct: 337 KSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFD 396
Query: 394 SYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSF 453
S+ AD+Y+ GL+ WE+ARRC SGG+ EEYQLPY+DLVPSDPS E+MR++VC +KLRP+
Sbjct: 397 SFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNI 456
Query: 454 PNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 502
PN W S E LR MGK+M ECW N A+RLTALR+KKTL+++S +D+K+
Sbjct: 457 PNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI 505
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 464 bits (1195), Expect = e-131
Identities = 253/491 (51%), Positives = 326/491 (66%), Gaps = 19/491 (3%)
Query: 19 ESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGY-CFTMIEEDDSGLPVVTSGCLGL-EG 76
E P PK+ C C S N +G CF+ + +D G V GC + E
Sbjct: 22 EDEKPKVNPKLYMCVCEGL----SCGNEDHCEGQQCFSSLSIND-GFHVYQKGCFQVYEQ 76
Query: 77 SDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRA---LLISVT 133
C+ P P Q ++ECC + + CN+++ LP K + F H +++SV
Sbjct: 77 GKMTCKTPPSPGQ--AVECC-QGDWCNRNITAQLPT-KGKSFPGTQNFHLEVGLIILSVV 132
Query: 134 --VCSLLLVLIILFCYFRYKRQET-RPR-YSIGLEQDETYIPPGES-LRDLIEQSQSSGS 188
VC L +L + F+ + QE PR G + G+S L DL++ S +SGS
Sbjct: 133 FAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGS 192
Query: 189 GSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIY 248
GSGLP LVQRT+A+QI +++ +GKGRYGEVW G W+GE VAVK+F + +E SWFRETE+Y
Sbjct: 193 GSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELY 252
Query: 249 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSS 308
TV++RHENILGFIA+D+ S TQL+LIT YHE GSLYDYL+ TTLD S L++ S
Sbjct: 253 NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSI 312
Query: 309 VSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPP 368
SGL HLH EIF TQGKPAIAHRDLKSKNILVKKNG CCIADLGLAV TN++D+
Sbjct: 313 ASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGN 372
Query: 369 NTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYH 428
N RVGTKRYM PEVLDE++ + F SY D+++FGL+LWEVARR VS GIVE+Y+ P++
Sbjct: 373 NPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFY 432
Query: 429 DLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVK 488
D+VP+DPS+EDMR++VC+ + RP+ PNRW SD L + KLM ECW NP++RLTALR+K
Sbjct: 433 DVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIK 492
Query: 489 KTLAKMSESQD 499
KTL K+ S D
Sbjct: 493 KTLTKIDNSLD 503
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 464 bits (1195), Expect = e-131
Identities = 253/491 (51%), Positives = 326/491 (66%), Gaps = 19/491 (3%)
Query: 19 ESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGY-CFTMIEEDDSGLPVVTSGCLGL-EG 76
E P PK+ C C S N +G CF+ + +D G V GC + E
Sbjct: 22 EDEKPKVNPKLYMCVCEGL----SCGNEDHCEGQQCFSSLSIND-GFHVYQKGCFQVYEQ 76
Query: 77 SDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRA---LLISVT 133
C+ P P Q ++ECC + + CN+++ LP K + F H +++SV
Sbjct: 77 GKMTCKTPPSPGQ--AVECC-QGDWCNRNITAQLPT-KGKSFPGTQNFHLEVGLIILSVV 132
Query: 134 --VCSLLLVLIILFCYFRYKRQET-RPR-YSIGLEQDETYIPPGES-LRDLIEQSQSSGS 188
VC L +L + F+ + QE PR G + G+S L DL++ S +SGS
Sbjct: 133 FAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGS 192
Query: 189 GSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIY 248
GSGLP LVQRT+A+QI +++ +GKGRYGEVW G W+GE VAVK+F + +E SWFRETE+Y
Sbjct: 193 GSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELY 252
Query: 249 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSS 308
TV++RHENILGFIA+D+ S TQL+LIT YHE GSLYDYL+ TTLD S L++ S
Sbjct: 253 NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSI 312
Query: 309 VSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPP 368
SGL HLH EIF TQGKPAIAHRDLKSKNILVKKNG CCIADLGLAV TN++D+
Sbjct: 313 ASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGN 372
Query: 369 NTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYH 428
N RVGTKRYM PEVLDE++ + F SY D+++FGL+LWEVARR VS GIVE+Y+ P++
Sbjct: 373 NPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFY 432
Query: 429 DLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVK 488
D+VP+DPS+EDMR++VC+ + RP+ PNRW SD L + KLM ECW NP++RLTALR+K
Sbjct: 433 DVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIK 492
Query: 489 KTLAKMSESQD 499
KTL K+ S D
Sbjct: 493 KTLTKIDNSLD 503
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 457 bits (1176), Expect = e-128
Identities = 247/468 (52%), Positives = 318/468 (67%), Gaps = 16/468 (3%)
Query: 41 DSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQ--CRDTPIPHQRRSIECCTE 98
DS N C T+G C+ + + V+ S C+ L + Q C + + ECC
Sbjct: 34 DSSNFTCQTEGACWASVMLTNGKEQVIKS-CVSLPELNAQVFCHSS---NNVTKTECCFT 89
Query: 99 RNECNKDLH-PTLPPLKNRDFVDGPIHHRALLISVTVC--SLLLVLIILFCYFRY--KRQ 153
N LH PT P + GP+ A++I+V VC S+ +L + C R R+
Sbjct: 90 DFCNNITLHLPTASPNAPKL---GPME-LAIIITVPVCLLSIAAMLTVWACQGRQCSYRK 145
Query: 154 ETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKG 213
+ RP L + + G++L+DLI +SGSGSGLPLLVQRTIA+ I + + +GKG
Sbjct: 146 KKRPNVEEPLSECNL-VNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKG 204
Query: 214 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 273
R+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++RHENILGFIAAD K G+WT
Sbjct: 205 RFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT 264
Query: 274 QLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDL 333
QL+L+++YHE GSLYDYL + M+KLA S SGL HLH EI TQGKPAIAHRD+
Sbjct: 265 QLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDI 324
Query: 334 KSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQ 393
KSKNILVKK TC IADLGLAVK S N +DIP N +VGTKRYM PE+LD+++N N F+
Sbjct: 325 KSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFE 384
Query: 394 SYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSF 453
S+ AD+YS GL+ WE+ARRC GGIVEEYQLPY+D+VPSDPS E+MR++VC +K RPS
Sbjct: 385 SFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSI 444
Query: 454 PNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIK 501
PN+W S E LR MG++M ECW N A+RLTALR+KKT++++ +D K
Sbjct: 445 PNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 492
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 451 bits (1161), Expect = e-127
Identities = 212/313 (67%), Positives = 259/313 (82%)
Query: 190 SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQ 249
+GLPLLVQRTIA+ I + + IGKGR+GEVW GKWRGE+VAVK+F + EE SWFRE EIYQ
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 250 TVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV 309
TV++RHENILGFIAAD K G+WTQL+L++DYHE+GSL+DYL T+ + M+KLA S+
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 310 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 369
SGL HLH EI TQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV+ S T+ +DI PN
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 370 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHD 429
RVGTKRYM PEVLD+S+N HF+S+ AD+Y+ GL+ WE+ARRC GGI E+YQLPY+D
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 430 LVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKK 489
LVPSDPS E+MR++VC +KLRP+ PNRW S E LR M K+M ECW N A+RLTALR+KK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 490 TLAKMSESQDIKL 502
TL+++S+ + IK+
Sbjct: 414 TLSQLSQQEGIKM 426
Score = 32.7 bits (73), Expect = 0.79
Identities = 33/105 (31%), Positives = 44/105 (41%), Gaps = 14/105 (13%)
Query: 20 STAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDF 79
+ A P L+C CH C +D N C TDG CF + E + + S C+ D
Sbjct: 24 AAALLPGATALQCFCHL-CTKD--NFTCVTDGLCFVSVTETTDKV-IHNSMCIA--EIDL 77
Query: 80 QCRDTPI---PHQRR---SIECCTERNECNKDLHPT--LPPLKNR 116
RD P P + + C ++ CNK PT LP L R
Sbjct: 78 IPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTGLPLLVQR 122
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 449 bits (1155), Expect = e-126
Identities = 234/413 (56%), Positives = 296/413 (71%), Gaps = 10/413 (2%)
Query: 94 ECCTERNECNKDLH-PTLPPLKNRDFVDGPIHHRALLISVTVC--SLLLVLIILFCYFRY 150
ECC N LH PT P + GP+ A++I+V VC S+ +L + C R
Sbjct: 35 ECCFTDFCNNITLHLPTASPNAPKL---GPME-LAIIITVPVCLLSIAAMLTVWACQGRQ 90
Query: 151 --KRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVK 208
R++ RP L + + G++L+DLI +SGSGSGLPLLVQRTIA+ I + +
Sbjct: 91 CSYRKKKRPNVEEPLSECNL-VNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 149
Query: 209 QIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKG 268
+GKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++RHENILGFIAAD K
Sbjct: 150 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 209
Query: 269 TGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAI 328
G+WTQL+L+++YHE GSLYDYL + M+KLA S SGL HLH EI TQGKPAI
Sbjct: 210 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 269
Query: 329 AHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLN 388
AHRD+KSKNILVKK TC IADLGLAVK S N +DIP N +VGTKRYM PE+LD+++N
Sbjct: 270 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 329
Query: 389 RNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKK 448
N F+S+ AD+YS GL+ WE+ARRC GGIVEEYQLPY+D+VPSDPS E+MR++VC +K
Sbjct: 330 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 389
Query: 449 LRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIK 501
RPS PN+W S E LR MG++M ECW N A+RLTALR+KKT++++ +D K
Sbjct: 390 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 442
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 422 bits (1084), Expect = e-118
Identities = 200/312 (64%), Positives = 247/312 (79%)
Query: 190 SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQ 249
+GLPLLVQRTIA+ I + + +GKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQ
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 250 TVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV 309
TV++RHENILGFIAAD K G+WTQL+L+++YHE GSLYDYL + M+KLA S
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 310 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 369
SGL HLH EI TQGKPAIAHRD+KSKNILVKK TC IADLGLAVK S N +DIP N
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 370 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHD 429
+VGTKRYM PE+LD+++N N F+S+ AD+YS GL+ WE+ARRC GGIVEEYQLPY+D
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 430 LVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKK 489
+VPSDPS E+MR++VC +K RPS PN+W S E LR MG++M ECW N A+RLTALR+KK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 490 TLAKMSESQDIK 501
T++++ +D K
Sbjct: 401 TISQLCVKEDCK 412
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 420 bits (1079), Expect = e-117
Identities = 224/428 (52%), Positives = 285/428 (66%), Gaps = 16/428 (3%)
Query: 44 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGL-----EGSDFQCRDTPIPHQRRSIECCTE 98
N C TDG C I D G+ C+ G F C + R+ CC
Sbjct: 43 NYTCETDGACMVSIFNLD-GMEHHVRTCIPKVELVPAGKPFYCLSS---EDLRNTHCCYT 98
Query: 99 RNECNK-DLHPTLPPLKNRDFVD--GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQET 155
+ CN+ DL LK + GP+ + I+ V L L++II+F Y ++
Sbjct: 99 -DYCNRIDLRVPSGHLKEPEHPSMWGPVELVGI-IAGPVFLLFLIIIIVFLVINYHQRVY 156
Query: 156 RPRYSIGLEQD--ETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKG 213
R + +E E + ++L+DL+ +SGSGSGLPL VQRT+A+ I + + IGKG
Sbjct: 157 HNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKG 216
Query: 214 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 273
R+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K G+WT
Sbjct: 217 RFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT 276
Query: 274 QLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDL 333
QL+L++DYHE+GSL+DYL T+ + M+KLA S+ SGL HLH EI TQGKP IAHRDL
Sbjct: 277 QLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDL 336
Query: 334 KSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQ 393
KSKNILVKKNG C IADLGLAV+ + T+ +DI PN RVGTKRYM PEVLDE++N HF
Sbjct: 337 KSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFD 396
Query: 394 SYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSF 453
S+ AD+Y+ GL+ WE+ARRC SGG+ EEYQLPY+DLVPSDPS E+MR++VC +KLRP+
Sbjct: 397 SFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNI 456
Query: 454 PNRWSSDE 461
PN W S E
Sbjct: 457 PNWWQSYE 464
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 416 bits (1068), Expect = e-116
Identities = 225/492 (45%), Positives = 309/492 (62%), Gaps = 25/492 (5%)
Query: 18 GESTAPTPRPKVLRCKCHH-HCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEG 76
G+ P+ P V C C HC + +C ++ ++ P GC L
Sbjct: 21 GDPVKPSRGPLVT-CTCESPHCKGPTCRG-----AWCTVVLVREEGRHPQEHRGCGNLHR 74
Query: 77 SDFQCRDTPIPHQRRSIECCTERNECNKD----LHPTLPPLKNRDFVDGPIHHRALLISV 132
CR P C + + CN + L T PP + DG + AL++
Sbjct: 75 E--LCRGRPTEFVNHY---CCDSHLCNHNVSLVLEATQPP-SEQPGTDGQL---ALILGP 125
Query: 133 TVCSLLLVLI-ILFCYFRYKRQETRPRYSIGLEQDETYIPPGES----LRDLIEQSQSSG 187
+ L LV + +L + +RQE + L + + E L DL++ ++G
Sbjct: 126 VLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTG 185
Query: 188 SGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEI 247
SGSGLP LVQRT+A+Q+ +V+ +GKGRYGEVW G W GE VAVK+F + +E SWFRETEI
Sbjct: 186 SGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEI 245
Query: 248 YQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYS 307
Y TVL+RH+NILGFIA+D+ S TQL+LIT YHE+GSLYD+L+ TL+ L+LA S
Sbjct: 246 YNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVS 305
Query: 308 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 367
+ GL HLH EIF TQGKPAIAHRD KS+N+LVK N CCIADLGLAV ++ +DI
Sbjct: 306 AACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 365
Query: 368 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPY 427
N RVGTKRYM PEVLDE + + F+SY D+++FGL+LWE+ARR + GIVE+Y+ P+
Sbjct: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 425
Query: 428 HDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRV 487
+D+VP+DPS+EDM+++VC+ + P+ PNR ++D L + ++M ECW NP++RLTALR+
Sbjct: 426 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 485
Query: 488 KKTLAKMSESQD 499
KKTL K+S S +
Sbjct: 486 KKTLQKISNSPE 497
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 416 bits (1068), Expect = e-116
Identities = 225/492 (45%), Positives = 309/492 (62%), Gaps = 25/492 (5%)
Query: 18 GESTAPTPRPKVLRCKCHH-HCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEG 76
G+ P+ P V C C HC + +C ++ ++ P GC L
Sbjct: 21 GDPVKPSRGPLVT-CTCESPHCKGPTCRG-----AWCTVVLVREEGRHPQEHRGCGNLHR 74
Query: 77 SDFQCRDTPIPHQRRSIECCTERNECNKD----LHPTLPPLKNRDFVDGPIHHRALLISV 132
CR P C + + CN + L T PP + DG + AL++
Sbjct: 75 E--LCRGRPTEFVNHY---CCDSHLCNHNVSLVLEATQPP-SEQPGTDGQL---ALILGP 125
Query: 133 TVCSLLLVLI-ILFCYFRYKRQETRPRYSIGLEQDETYIPPGES----LRDLIEQSQSSG 187
+ L LV + +L + +RQE + L + + E L DL++ ++G
Sbjct: 126 VLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTG 185
Query: 188 SGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEI 247
SGSGLP LVQRT+A+Q+ +V+ +GKGRYGEVW G W GE VAVK+F + +E SWFRETEI
Sbjct: 186 SGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEI 245
Query: 248 YQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYS 307
Y TVL+RH+NILGFIA+D+ S TQL+LIT YHE+GSLYD+L+ TL+ L+LA S
Sbjct: 246 YNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVS 305
Query: 308 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 367
+ GL HLH EIF TQGKPAIAHRD KS+N+LVK N CCIADLGLAV ++ +DI
Sbjct: 306 AACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 365
Query: 368 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPY 427
N RVGTKRYM PEVLDE + + F+SY D+++FGL+LWE+ARR + GIVE+Y+ P+
Sbjct: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 425
Query: 428 HDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRV 487
+D+VP+DPS+EDM+++VC+ + P+ PNR ++D L + ++M ECW NP++RLTALR+
Sbjct: 426 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 485
Query: 488 KKTLAKMSESQD 499
KKTL K+S S +
Sbjct: 486 KKTLQKISNSPE 497
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 357 bits (915), Expect = 2e-98
Identities = 195/385 (50%), Positives = 249/385 (64%), Gaps = 16/385 (4%)
Query: 44 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGL-----EGSDFQCRDTPIPHQRRSIECCTE 98
N C TDG C I D G+ C+ G F C + R+ CC
Sbjct: 43 NYTCETDGACMVSIFNLD-GMEHHVRTCIPKVELVPAGKPFYCLSS---EDLRNTHCCYT 98
Query: 99 RNECNK-DLHPTLPPLKNRDFVD--GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQET 155
+ CN+ DL LK + GP+ + I+ V L L++II+F Y ++
Sbjct: 99 -DYCNRIDLRVPSGHLKEPEHPSMWGPVELVGI-IAGPVFLLFLIIIIVFLVINYHQRVY 156
Query: 156 RPRYSIGLEQD--ETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKG 213
R + +E E + ++L+DL+ +SGSGSGLPL VQRT+A+ I + + IGKG
Sbjct: 157 HNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKG 216
Query: 214 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 273
R+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K G+WT
Sbjct: 217 RFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT 276
Query: 274 QLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDL 333
QL+L++DYHE+GSL+DYL T+ + M+KLA S+ SGL HLH EI TQGKP IAHRDL
Sbjct: 277 QLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDL 336
Query: 334 KSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQ 393
KSKNILVKKNG C IADLGLAV+ + T+ +DI PN RVGTKRYM PEVLDE++N HF
Sbjct: 337 KSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFD 396
Query: 394 SYIMADMYSFGLILWEVARRCVSGG 418
S+ AD+Y+ GL+ WE+ARRC SGG
Sbjct: 397 SFKCADIYALGLVYWEIARRCNSGG 421
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 310 bits (794), Expect = 2e-84
Identities = 146/232 (62%), Positives = 181/232 (78%)
Query: 270 GSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIA 329
G+WTQL+L+++YHE GSLYDYL + M+KLA S SGL HLH EI TQGKPAIA
Sbjct: 104 GTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIA 163
Query: 330 HRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNR 389
HRD+KSKNILVKK TC IADLGLAVK S N +DIP N +VGTKRYM PE+LD+++N
Sbjct: 164 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV 223
Query: 390 NHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKL 449
N F+S+ AD+YS GL+ WE+ARRC GGIVEEYQLPY+D+VPSDPS E+MR++VC +K
Sbjct: 224 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF 283
Query: 450 RPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIK 501
RPS PN+W S E LR MG++M ECW N A+RLTALR+KKT++++ +D K
Sbjct: 284 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 335
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 240 bits (613), Expect = 2e-63
Identities = 159/465 (34%), Positives = 240/465 (51%), Gaps = 51/465 (10%)
Query: 52 YCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRD-TPIPHQRRSIE---CCTERNECNKDL- 106
+CF + + +V GC D C D T ++ S E CC E N CN+
Sbjct: 59 HCFATWKNISGSIEIVKQGCWL---DDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFS 115
Query: 107 --------HPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPR 158
PT P+ + P ++ LL S+ L+L+ I+ C F R
Sbjct: 116 YFPEMEVTQPTSNPVTPK-----PPYYNILLYSLV--PLMLIAGIVICAFWVYRHH---- 164
Query: 159 YSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEV 218
+ PP ++ +Q G PLL K +Q+++ +GR+G V
Sbjct: 165 --------KMAYPP------VLVPTQDPGPPPPSPLLG----LKPLQLLEVKARGRFGCV 206
Query: 219 WMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLI 278
W + E VAVK+F ++ SW E E+Y M+HENIL FI A+ +GT L+LI
Sbjct: 207 WKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLI 266
Query: 279 TDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEI--FSTQGKPAIAHRDLKSK 336
T +HE GSL D+LK+ + + +A + GL +LH +I KPAI+HRD+KSK
Sbjct: 267 TAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSK 326
Query: 337 NILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYI 396
N+L+K N T CIAD GLA+KF + + D + +VGT+RYM PEVL+ ++N +++
Sbjct: 327 NVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQR-DAFL 383
Query: 397 MADMYSFGLILWEVARRCVSG-GIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPN 455
DMY+ GL+LWE+A RC + G V+EY LP+ + + PS EDM+E+V KK RP +
Sbjct: 384 RIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRD 443
Query: 456 RWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDI 500
W + + + + ECW H+ +RL+A V + + +M +I
Sbjct: 444 YWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 230 bits (586), Expect = 3e-60
Identities = 151/461 (32%), Positives = 239/461 (51%), Gaps = 49/461 (10%)
Query: 52 YCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRD----TPIPHQRRSIECCTERNECNKDLH 107
+C+ + +V GC DF C D + CC E N CN+
Sbjct: 58 HCYASWRNSSGTIELVKKGCWL---DDFNCYDRQECVATEENPQVYFCCCEGNFCNERF- 113
Query: 108 PTLPPLKNRDFVDGPIHHRALLISVTVCSLL----LVLIILFCYFRYKRQETRPRYSIGL 163
LP + P L++V SLL L LI+L ++ Y+ ++ P + +
Sbjct: 114 THLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKP-PYGHVDI 172
Query: 164 EQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKW 223
+D PP + GL K +Q+++ +GR+G VW +
Sbjct: 173 HEDPGPPPPSPLV--------------GL---------KPLQLLEIKARGRFGCVWKAQL 209
Query: 224 RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHE 283
+ VAVK+F ++ SW E EI+ T M+HEN+L FIAA+ +G+ +L+LIT +H+
Sbjct: 210 MNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHD 269
Query: 284 NGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQG---KPAIAHRDLKSKNILV 340
GSL DYLK + + +A + GL +LH ++ +G KP+IAHRD KSKN+L+
Sbjct: 270 KGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLL 329
Query: 341 KKNGTCCIADLGLAVKFISDTNEVDIPP---NTRVGTKRYMPPEVLDESLNRNHFQSYIM 397
K + T +AD GLAV+F E PP + +VGT+RYM PEVL+ ++N +++
Sbjct: 330 KSDLTAVLADFGLAVRF-----EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQR-DAFLR 383
Query: 398 ADMYSFGLILWEVARRC-VSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNR 456
DMY+ GL+LWE+ RC + G V+EY LP+ + + PS E+++E+V KK+RP+ +
Sbjct: 384 IDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDH 443
Query: 457 WSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSES 497
W L Q+ + ECW H+ +RL+A V++ ++ + S
Sbjct: 444 WLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS 484
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 218 bits (554), Expect = 1e-56
Identities = 152/470 (32%), Positives = 230/470 (48%), Gaps = 45/470 (9%)
Query: 46 ICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCR-------DTPIPHQRRSIE-CCT 97
+CS C+ + E+ + +V GC G +C TP Q + CC
Sbjct: 59 LCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCC 118
Query: 98 ERNECNKDLHPTLPPLKNRDFVDGPIHHR--ALLISVTVCSLLLVLIILFCYFRYKRQET 155
+ CN + PP +R ++I++ S+L VLI+ C F Y R T
Sbjct: 119 STDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALC-FGY-RMLT 176
Query: 156 RPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRY 215
R GL + +++ S L L +++++ IG+GRY
Sbjct: 177 GDRKQ-GLHS--------------MNMMEAAASEPSLDL-------DNLKLLELIGRGRY 214
Query: 216 GEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQL 275
G V+ G VAVKVF ++ E IY+ LM H+NI FI D + T
Sbjct: 215 GAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRME 274
Query: 276 Y-LITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEI-FSTQGKPAIAHRDL 333
Y L+ +Y+ NGSL YL T D S +LA+S GL +LHTE+ KPAI+HRDL
Sbjct: 275 YLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDL 334
Query: 334 KSKNILVKKNGTCCIADLGLAVKFISD----TNEVDIPPNTRVGTKRYMPPEVLDESLNR 389
S+N+LVK +GTC I+D GL+++ + E D + VGT RYM PEVL+ ++N
Sbjct: 335 NSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNL 394
Query: 390 NHFQSYI-MADMYSFGLILWEVARRCVS---GGIVEEYQLPYHDLVPSDPSYEDMREIVC 445
+S + DMY+ GLI WE+ RC G V EYQ+ + V + P++EDM+ +V
Sbjct: 395 RDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVS 454
Query: 446 IKKLRPSFPNRWSSDE-CLRQMGKLMTECWAHNPASRLTALRVKKTLAKM 494
+K RP FP W + +R + + + +CW + +RLTA ++ +A++
Sbjct: 455 REKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 216 bits (549), Expect = 5e-56
Identities = 131/415 (31%), Positives = 219/415 (52%), Gaps = 24/415 (5%)
Query: 95 CCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLL-------LVLIILFCY 147
C +ECN ++ + + ++ ++ VT SLL V+II +CY
Sbjct: 136 CSCSSDECNDNI------IFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCY 189
Query: 148 FRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMV 207
++Q+ + G + + E ++E +S S + + T I++
Sbjct: 190 RVNRQQKLSSTWETG--KTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 247
Query: 208 KQIGKGRYGEVWMGKWRG------EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 261
+GKGR+ EV+ K + E VAVK+F E ASW E +I+ + ++HENIL F
Sbjct: 248 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 307
Query: 262 IAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFS 321
+ A+ + T Q +LIT +H G+L +YL + + + KL S G+ HLH++ +
Sbjct: 308 LTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD-HT 366
Query: 322 TQGKPA--IAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 379
G+P I HRDLKS NILVK + TCC+ D GL+++ + D+ + +VGT RYM
Sbjct: 367 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMA 426
Query: 380 PEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYED 439
PEVL+ +N + +S+ D+YS L+LWE+ RC + G V++Y+ P+ V P E
Sbjct: 427 PEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVES 486
Query: 440 MREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKM 494
M++ V + RP P+ W + + ++ + + +TECW H+P +RLTA V + +++
Sbjct: 487 MKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 216 bits (549), Expect = 5e-56
Identities = 131/415 (31%), Positives = 219/415 (52%), Gaps = 24/415 (5%)
Query: 95 CCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLL-------LVLIILFCY 147
C +ECN ++ + + ++ ++ VT SLL V+II +CY
Sbjct: 161 CSCSSDECNDNI------IFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCY 214
Query: 148 FRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMV 207
++Q+ + G + + E ++E +S S + + T I++
Sbjct: 215 RVNRQQKLSSTWETG--KTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 272
Query: 208 KQIGKGRYGEVWMGKWRG------EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 261
+GKGR+ EV+ K + E VAVK+F E ASW E +I+ + ++HENIL F
Sbjct: 273 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 332
Query: 262 IAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFS 321
+ A+ + T Q +LIT +H G+L +YL + + + KL S G+ HLH++ +
Sbjct: 333 LTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD-HT 391
Query: 322 TQGKPA--IAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 379
G+P I HRDLKS NILVK + TCC+ D GL+++ + D+ + +VGT RYM
Sbjct: 392 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMA 451
Query: 380 PEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYED 439
PEVL+ +N + +S+ D+YS L+LWE+ RC + G V++Y+ P+ V P E
Sbjct: 452 PEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVES 511
Query: 440 MREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKM 494
M++ V + RP P+ W + + ++ + + +TECW H+P +RLTA V + +++
Sbjct: 512 MKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 566
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 157 bits (396), Expect = 3e-38
Identities = 102/308 (33%), Positives = 162/308 (52%), Gaps = 21/308 (6%)
Query: 210 IGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT 269
I +G + VW G+ +G+ VA+K F A + E +Y+ ++H++I+ FI A G
Sbjct: 209 IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGP 268
Query: 270 GSWTQ-LYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST-QGKPA 327
G L+ + H GSL YL T D S L++A S GL LH E + Q KP
Sbjct: 269 GRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPG 328
Query: 328 IAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN--------TRVGTKRYMP 379
IAHRDL S+N+L++++G+C I DLGLA+ T P GT+RYM
Sbjct: 329 IAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMA 388
Query: 380 PEVLDESLNRNHF-QSYIMADMYSFGLILWEVARRCVS---GGIVEEYQLPYHDLVPSDP 435
PE+LD++L+ + + AD+YS L+LWE+ RC +QL Y + + P
Sbjct: 389 PELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTP 448
Query: 436 SYEDMREIVCIKKLRPSFPNRW----SSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 491
+ +++ + ++ RP P+ W + + LR+ L+ +CW +P +RLTA V++ L
Sbjct: 449 TSDELWALAVQERRRPYIPSTWRCFATDPDGLRE---LLEDCWDADPEARLTAECVQQRL 505
Query: 492 AKMSESQD 499
A ++ Q+
Sbjct: 506 AALAHPQE 513
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 100 bits (250), Expect = 2e-21
Identities = 89/339 (26%), Positives = 149/339 (43%), Gaps = 66/339 (19%)
Query: 174 ESLRDLIEQSQSSGSGSGL----PLLVQRTIA--------------KQIQMVKQIGKGRY 215
E+L L+E S G P +++ T+A K++++++ IGKG +
Sbjct: 147 ENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEF 206
Query: 216 GEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQL 275
G+V +G +RG KVAVK A F T L RH N++ + ++ G L
Sbjct: 207 GDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL-RHSNLVQLLGVIVEEKGG---L 262
Query: 276 YLITDYHENGSLYDYLKS---TTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRD 332
Y++T+Y GSL DYL+S + L +LK + + +L F HRD
Sbjct: 263 YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF--------VHRD 314
Query: 333 LKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHF 392
L ++N+LV ++ ++D GL T E +T ++ PE L E
Sbjct: 315 LAARNVLVSEDNVAKVSDFGL-------TKEASSTQDTGKLPVKWTAPEALREK------ 361
Query: 393 QSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPS 452
+ +D++SFG++LWE+ S G V ++P D+VP M
Sbjct: 362 KFSTKSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGYKMD----------- 406
Query: 453 FPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 491
+ D C + ++M CW + A R + L++++ L
Sbjct: 407 -----APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL 440
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 100 bits (250), Expect = 2e-21
Identities = 89/339 (26%), Positives = 149/339 (43%), Gaps = 66/339 (19%)
Query: 174 ESLRDLIEQSQSSGSGSGL----PLLVQRTIA--------------KQIQMVKQIGKGRY 215
E+L L+E S G P +++ T+A K++++++ IGKG +
Sbjct: 147 ENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEF 206
Query: 216 GEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQL 275
G+V +G +RG KVAVK A F T L RH N++ + ++ G L
Sbjct: 207 GDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL-RHSNLVQLLGVIVEEKGG---L 262
Query: 276 YLITDYHENGSLYDYLKS---TTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRD 332
Y++T+Y GSL DYL+S + L +LK + + +L F HRD
Sbjct: 263 YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF--------VHRD 314
Query: 333 LKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHF 392
L ++N+LV ++ ++D GL T E +T ++ PE L E
Sbjct: 315 LAARNVLVSEDNVAKVSDFGL-------TKEASSTQDTGKLPVKWTAPEALREK------ 361
Query: 393 QSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPS 452
+ +D++SFG++LWE+ S G V ++P D+VP M
Sbjct: 362 KFSTKSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGYKMD----------- 406
Query: 453 FPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 491
+ D C + ++M CW + A R + L++++ L
Sbjct: 407 -----APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL 440
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 92.8 bits (229), Expect = 6e-19
Identities = 87/335 (25%), Positives = 149/335 (44%), Gaps = 69/335 (20%)
Query: 174 ESLRDLIEQSQSSGSG----------SGLPLLVQRTIA---------KQIQMVKQIGKGR 214
E+L+ L++ +G G+P L ++ + +Q++K++G G+
Sbjct: 222 ETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQ 281
Query: 215 YGEVWMGKWRGE-KVAVKVF--FTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGS 271
+GEVWMG W G KVA+K T S+ E +I + ++H+ ++ A S
Sbjct: 282 FGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK--LKHDKLVQLYA-----VVS 334
Query: 272 WTQLYLITDYHENGSLYDYLK---STTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAI 328
+Y++T+Y GSL D+LK L +++ +A +G+ ++ +
Sbjct: 335 EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE--------RMNY 386
Query: 329 AHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLN 388
HRDL+S NILV C IAD GLA + I D NE + K P L
Sbjct: 387 IHRDLRSANILVGNGLICKIADFGLA-RLIED-NEYTARQGAKFPIKWTAPEAAL----- 439
Query: 389 RNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKK 448
+ + I +D++SFG++L E +V + ++PY P + E + ++ +
Sbjct: 440 --YGRFTIKSDVWSFGILLTE---------LVTKGRVPY----PGMNNREVLEQVE--RG 482
Query: 449 LRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 483
R P +C + +LM CW +P R T
Sbjct: 483 YRMPCP-----QDCPISLHELMIHCWKKDPEERPT 512
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 92.4 bits (228), Expect = 8e-19
Identities = 82/287 (28%), Positives = 132/287 (45%), Gaps = 52/287 (18%)
Query: 204 IQMVKQIGKGRYGEVWMGKWRGE-KVAVKVFFTTEEASWFRETEIYQTVLMR---HENIL 259
+++V+++G G++GEVWMG + G KVAVK + ++ S + + + LM+ H+ ++
Sbjct: 245 LKLVERLGAGQFGEVWMGYYNGHTKVAVK---SLKQGSMSPDAFLAEANLMKQLQHQRLV 301
Query: 260 GFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSSVSGLCHLH 316
A + +Y+IT+Y ENGSL D+LK+ + L +L +A G+ +
Sbjct: 302 RLYAVVTQ-----EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE 356
Query: 317 TEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKR 376
+ HRDL++ NILV +C IAD GLA + I D NE + K
Sbjct: 357 ERNY--------IHRDLRAANILVSDTLSCKIADFGLA-RLIED-NEYTAREGAKFPIKW 406
Query: 377 YMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPS 436
P E++N F I +D++SFG++L E+ H +P
Sbjct: 407 TAP-----EAINYGTFT--IKSDVWSFGILLTEIVT---------------HGRIP---- 440
Query: 437 YEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 483
Y M I+ L + D C ++ +LM CW P R T
Sbjct: 441 YPGMTNPEVIQNLERGY-RMVRPDNCPEELYQLMRLCWKERPEDRPT 486
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 92.4 bits (228), Expect = 8e-19
Identities = 82/287 (28%), Positives = 132/287 (45%), Gaps = 52/287 (18%)
Query: 204 IQMVKQIGKGRYGEVWMGKWRGE-KVAVKVFFTTEEASWFRETEIYQTVLMR---HENIL 259
+++V+++G G++GEVWMG + G KVAVK + ++ S + + + LM+ H+ ++
Sbjct: 245 LKLVERLGAGQFGEVWMGYYNGHTKVAVK---SLKQGSMSPDAFLAEANLMKQLQHQRLV 301
Query: 260 GFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSSVSGLCHLH 316
A + +Y+IT+Y ENGSL D+LK+ + L +L +A G+ +
Sbjct: 302 RLYAVVTQ-----EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE 356
Query: 317 TEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKR 376
+ HRDL++ NILV +C IAD GLA + I D NE + K
Sbjct: 357 ERNY--------IHRDLRAANILVSDTLSCKIADFGLA-RLIED-NEYTAREGAKFPIKW 406
Query: 377 YMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPS 436
P E++N F I +D++SFG++L E+ H +P
Sbjct: 407 TAP-----EAINYGTFT--IKSDVWSFGILLTEIVT---------------HGRIP---- 440
Query: 437 YEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 483
Y M I+ L + D C ++ +LM CW P R T
Sbjct: 441 YPGMTNPEVIQNLERGY-RMVRPDNCPEELYQLMRLCWKERPEDRPT 486
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 91.3 bits (225), Expect = 2e-18
Identities = 81/302 (26%), Positives = 136/302 (45%), Gaps = 53/302 (17%)
Query: 204 IQMVKQIGKGRYGEVWMGKW--RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 261
+Q + G G +G V+ KW + ++VAVK E +E EI ++ H NI+ F
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQF 68
Query: 262 IAADIKGTGSWTQLYLITDYHENGSLYDYL---KSTTLDAKSMLKLAYSSVSGLCHLHTE 318
++ ++T+Y GSLYDY+ +S +D ++ A G+ +LH E
Sbjct: 69 YGVILEPPNYG----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 124
Query: 319 IFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYM 378
+ HRDLKS+N+++ +G I D G A +F + T + + VGT +M
Sbjct: 125 -----APVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSL-----VGTFPWM 173
Query: 379 PPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 438
PEV+ +SL + D YS+G++LWE+ R V +E Q+ +
Sbjct: 174 APEVI-QSLPVSE-----TCDTYSYGVVLWEMLTREVPFKGLEGLQVAW----------- 216
Query: 439 DMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQ 498
+V K R + P+ C R +L+ +CW + R + ++ L MS
Sbjct: 217 ----LVVEKNERLTIPS-----SCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT 267
Query: 499 DI 500
+
Sbjct: 268 SL 269
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 91.3 bits (225), Expect = 2e-18
Identities = 81/302 (26%), Positives = 136/302 (45%), Gaps = 53/302 (17%)
Query: 204 IQMVKQIGKGRYGEVWMGKW--RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 261
+Q + G G +G V+ KW + ++VAVK E +E EI ++ H NI+ F
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQF 68
Query: 262 IAADIKGTGSWTQLYLITDYHENGSLYDYL---KSTTLDAKSMLKLAYSSVSGLCHLHTE 318
++ ++T+Y GSLYDY+ +S +D ++ A G+ +LH E
Sbjct: 69 YGVILEPPNYG----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 124
Query: 319 IFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYM 378
+ HRDLKS+N+++ +G I D G A +F + T + + VGT +M
Sbjct: 125 -----APVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSL-----VGTFPWM 173
Query: 379 PPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 438
PEV+ +SL + D YS+G++LWE+ R V +E Q+ +
Sbjct: 174 APEVI-QSLPVSE-----TCDTYSYGVVLWEMLTREVPFKGLEGLQVAW----------- 216
Query: 439 DMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQ 498
+V K R + P+ C R +L+ +CW + R + ++ L MS
Sbjct: 217 ----LVVEKNERLTIPS-----SCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT 267
Query: 499 DI 500
+
Sbjct: 268 SL 269
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 89.4 bits (220), Expect = 7e-18
Identities = 78/288 (27%), Positives = 132/288 (45%), Gaps = 50/288 (17%)
Query: 202 KQIQMVKQIGKGRYGEVWMGKWRGE-KVAVKVFF--TTEEASWFRETEIYQTVLMRHENI 258
+ +++ ++G+G +GEVWMG W G +VA+K T ++ +E ++ + +RHE +
Sbjct: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKL 325
Query: 259 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSSVSGLCHL 315
+ A S +Y++T+Y GSL D+LK T L ++ +A SG+ ++
Sbjct: 326 VQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380
Query: 316 HTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTK 375
+ HRDL++ NILV +N C +AD GLA + I D NE + K
Sbjct: 381 ERMNY--------VHRDLRAANILVGENLVCKVADFGLA-RLIED-NEYTARQGAKFPIK 430
Query: 376 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDP 435
P L + + I +D++SFG++L E + + ++PY +V
Sbjct: 431 WTAPEAAL-------YGRFTIKSDVWSFGILLTE---------LTTKGRVPYPGMV---- 470
Query: 436 SYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 483
RE++ + P EC + LM +CW P R T
Sbjct: 471 ----NREVLDQVERGYRMP---CPPECPESLHDLMCQCWRKEPEERPT 511
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 89.4 bits (220), Expect = 7e-18
Identities = 78/288 (27%), Positives = 132/288 (45%), Gaps = 50/288 (17%)
Query: 202 KQIQMVKQIGKGRYGEVWMGKWRGE-KVAVKVFF--TTEEASWFRETEIYQTVLMRHENI 258
+ +++ ++G+G +GEVWMG W G +VA+K T ++ +E ++ + +RHE +
Sbjct: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKL 325
Query: 259 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSSVSGLCHL 315
+ A S +Y++T+Y GSL D+LK T L ++ +A SG+ ++
Sbjct: 326 VQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380
Query: 316 HTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTK 375
+ HRDL++ NILV +N C +AD GLA + I D NE + K
Sbjct: 381 ERMNY--------VHRDLRAANILVGENLVCKVADFGLA-RLIED-NEYTARQGAKFPIK 430
Query: 376 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDP 435
P L + + I +D++SFG++L E + + ++PY +V
Sbjct: 431 WTAPEAAL-------YGRFTIKSDVWSFGILLTE---------LTTKGRVPYPGMV---- 470
Query: 436 SYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 483
RE++ + P EC + LM +CW P R T
Sbjct: 471 ----NREVLDQVERGYRMP---CPPECPESLHDLMCQCWRKEPEERPT 511
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,531,549
Number of Sequences: 37866
Number of extensions: 951175
Number of successful extensions: 3675
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 339
Number of HSP's successfully gapped in prelim test: 377
Number of HSP's that attempted gapping in prelim test: 2470
Number of HSP's gapped (non-prelim): 841
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.