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Search of human proteins with 4502421
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502421 bone morphogenetic protein 1 isoform 1 precursor
[Homo sapiens]
(730 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 1543 0.0
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 1487 0.0
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 1484 0.0
gi|6912724 tolloid-like 2 [Homo sapiens] 1125 0.0
gi|22547221 tolloid-like 1 [Homo sapiens] 1120 0.0
gi|126091152 cubilin [Homo sapiens] 204 2e-52
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 174 3e-43
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 165 1e-40
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 155 1e-37
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 154 2e-37
gi|13899255 membrane frizzled-related protein [Homo sapiens] 154 4e-37
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H... 153 6e-37
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr... 153 6e-37
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr... 153 6e-37
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 152 8e-37
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 150 4e-36
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 150 4e-36
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 150 4e-36
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 150 4e-36
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 150 4e-36
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 150 4e-36
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 146 6e-35
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 146 6e-35
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 146 6e-35
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr... 139 7e-33
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 139 9e-33
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 139 9e-33
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 139 9e-33
gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens] 138 2e-32
gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens] 138 2e-32
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 1543 bits (3994), Expect = 0.0
Identities = 730/730 (100%), Positives = 730/730 (100%)
Query: 1 MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1 MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
Query: 61 EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
Sbjct: 61 EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
Query: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRGRPHQLKF 720
LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRGRPHQLKF
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRGRPHQLKF 720
Query: 721 RVQKRNRTPQ 730
RVQKRNRTPQ
Sbjct: 721 RVQKRNRTPQ 730
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 1487 bits (3849), Expect = 0.0
Identities = 703/704 (99%), Positives = 704/704 (100%)
Query: 1 MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1 MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
Query: 61 EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
Sbjct: 61 EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
Query: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704
LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS+K
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDK 704
Score = 308 bits (788), Expect = 2e-83
Identities = 161/427 (37%), Positives = 231/427 (54%), Gaps = 47/427 (11%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG ++ G+ SP YP+ Y C+WRI V+ G + L F S ++ R C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
VRDG + L GR+CG + P+ I ST SRLW++F S + + K FAV
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
EA CGG + K G I SP +P +Y P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
+K CIW++ + + L F FE E +D C YD++EVR G + S L G++CG EKP+
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
I S + + ++F SD +++K GF +FF + DECS+ N GGC+Q C+NT GSY+C C G
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQQDCVNTFGSYECQCRSG 732
Query: 578 YELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFF 636
+ L +K C EA C +T +G+ITSP WP +YP K C W + + +R+ L F
Sbjct: 733 FVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEM 792
Query: 637 ETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
+ E C YD +EV G A + + G+FCGS+KPE + + + M + F SDN+V +KGF
Sbjct: 793 DIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF 852
Query: 697 KAHFFSE 703
+A +E
Sbjct: 853 QASHATE 859
Score = 208 bits (529), Expect = 2e-53
Identities = 127/427 (29%), Positives = 189/427 (44%), Gaps = 82/427 (19%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG L G+ +SP +P Y + +C+W++ +I L F + + +C YD+V
Sbjct: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
EVR G + L G+FCGS+ PE I S + + VEF+S + KGF A +
Sbjct: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
EA C V G I SPN+PD Y
Sbjct: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
K C W I + G V LTF +IE CAYD+LEV DG + ++GR+CG +KP+
Sbjct: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
+ +T SR++L+F SD S+ + GF + EC R + + L + +
Sbjct: 830 VLATGSRMFLRFYSDNSVQRKGFQAS---HATECGGQVRADVKTKDLYSHAQFG------ 880
Query: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
YP +C W +VA Y + L F FE
Sbjct: 881 ------------------------------DNNYPGGVDCEWVIVAEEGYGVELVFQTFE 910
Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
E C YD++E+ G + + G++CGS PE + S +++ V+F SD+T++KKGF
Sbjct: 911 VEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFH 970
Query: 698 AHFFSEK 704
+ S K
Sbjct: 971 LRYTSTK 977
Score = 177 bits (449), Expect = 3e-44
Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 45/280 (16%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CG ++ G+ SP YP+ Y C+WRI V+ G + L F S ++ R C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
VRDG + L GR+CG + P+ I ST SRLW++F S + + K FAV
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
EA CGG + K G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
+K CIW++ + + L F FE E +D C YD++EVR G + S L G++CG EKP+
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
I S + + ++F SD +++K GF +FF E +P RG
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRG 557
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 1484 bits (3842), Expect = 0.0
Identities = 702/702 (100%), Positives = 702/702 (100%)
Query: 1 MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1 MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
Query: 61 EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
Sbjct: 61 EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
Query: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
Score = 177 bits (449), Expect = 3e-44
Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 45/280 (16%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CG ++ G+ SP YP+ Y C+WRI V+ G + L F S ++ R C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
VRDG + L GR+CG + P+ I ST SRLW++F S + + K FAV
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
EA CGG + K G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
+K CIW++ + + L F FE E +D C YD++EVR G + S L G++CG EKP+
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
I S + + ++F SD +++K GF +FF E +P RG
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRG 557
Score = 172 bits (435), Expect = 1e-42
Identities = 94/272 (34%), Positives = 137/272 (50%), Gaps = 45/272 (16%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG ++ G+ SP YP+ Y C+WRI V+ G + L F S ++ R C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
VRDG + L GR+CG + P+ I ST SRLW++F S + + K FAV
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
EA CGG + K G I SP +P +Y P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
+K CIW++ + + L F FE E +D C YD++EVR G + S L G++CG EKP+
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549
I S + + ++F SD +++K GF +FF ++
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
Score = 81.6 bits (200), Expect = 2e-15
Identities = 41/117 (35%), Positives = 64/117 (54%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG L G+ +SP +P Y + +C+W++ +I L F + + +C YD+V
Sbjct: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
EVR G + L G+FCGS+ PE I S + + VEF+S + KGF A + ++ G
Sbjct: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEG 706
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 1125 bits (2909), Expect = 0.0
Identities = 536/746 (71%), Positives = 606/746 (81%), Gaps = 29/746 (3%)
Query: 1 MPGVARLPLLLGLLLL---PRPG-----RPLDLADYTYDLAEEDDSEPL-NYKDPCKAAA 51
MP L L+ LLLL PR RP ADY+ EE + L +Y DPCKAA
Sbjct: 1 MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAV 60
Query: 52 FLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTN----GQPQRG 107
F GDIALDE+DL+ F + +A D + T + ++ S T G + G
Sbjct: 61 FWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAG 120
Query: 108 ACGRWRGR----------------SRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVF 151
GR R RRA TSR ER+WP GVIP+VIGGNFTGSQRA+F
Sbjct: 121 KDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIF 180
Query: 152 RQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIV 211
+QAMRHWEKHTCVTF+ERTDE+S+IVF+YR CGCCSYVGRRGGGPQAISIGKNCDKFGIV
Sbjct: 181 KQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIV 240
Query: 212 VHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMH 271
HELGHVVGFWHEHTRPDRD+HV+I+RENIQPGQEYNFLKME EV SLGETYDFDSIMH
Sbjct: 241 AHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMH 300
Query: 272 YARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTG 331
YARNTFSRG+FLDTI+P+ + NGV+P IGQR RLS+GDIAQARKLYKCPACGETLQD+TG
Sbjct: 301 YARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTG 360
Query: 332 NFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAP 391
NFS+P +PNGY ++ HCVWRISVTPGEKI+LNFTS+DL++SRLCWYDYVEVRDG+WRKAP
Sbjct: 361 NFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAP 420
Query: 392 LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNY 451
L GRFCG K+PEP+VSTDSRLWVEFRSSSN +GKGFFA YEA CGGD+ KD G IQSPNY
Sbjct: 421 LLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNY 480
Query: 452 PDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCG 511
PDDYRPSK C+WRI VSEGFHVGLTFQ+FEIERHDSCAYDYLEVRDG +E S LIG +CG
Sbjct: 481 PDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCG 540
Query: 512 YEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYK 571
YEKP+D+KS+S+RLW+KFVSDGSINKAGFA NFFKEVDECS P+ GGCE RC+NTLGSYK
Sbjct: 541 YEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYK 600
Query: 572 CSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISL 631
C+CDPGYELA DK+ CE ACGGF+TKLNG+ITSPGWPKEYP NKNC+WQ+VAP QYRISL
Sbjct: 601 CACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISL 660
Query: 632 QFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTV 691
QF+ FE EGNDVCKYDFVEVRSGL+ D+KLHG+FCGSE PEVITSQ NNMRVEFKSDNTV
Sbjct: 661 QFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTV 720
Query: 692 SKKGFKAHFFSEKRPALQPPRGRPHQ 717
SK+GF+AHFFS+K + G H+
Sbjct: 721 SKRGFRAHFFSDKDECAKDNGGCQHE 746
Score = 292 bits (748), Expect = 7e-79
Identities = 147/421 (34%), Positives = 225/421 (53%), Gaps = 45/421 (10%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG + G SP YP+ Y CVWRI+V+ G + L F + ++ R C YDY+E
Sbjct: 464 CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLE 523
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
VRDG ++ L G FCG + PE + S+ +RLW++F S + GF A +
Sbjct: 524 VRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583
Query: 432 ---------------------------------EAICGGDVKKDYGHIQSPNYPDDYRPS 458
E CGG + K G I SP +P +Y +
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTN 643
Query: 459 KVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDI 518
K C+W++ + + L F+ FE+E +D C YD++EVR G S + L GR+CG E P+ I
Sbjct: 644 KNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVI 703
Query: 519 KSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGY 578
S S+ + ++F SD +++K GF +FF + DEC++ N GGC+ C+NT GSY C C GY
Sbjct: 704 TSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDN-GGCQHECVNTFGSYLCRCRNGY 762
Query: 579 ELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
L + C EA C ++ + G++ SP WP +YP + C W + + +R+ L F+ FE
Sbjct: 763 WLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFE 822
Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
E + C YD +E+ G + + + G+FCGS+KP+ + ++M + F SD +V +KGF+
Sbjct: 823 IEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQ 882
Query: 698 A 698
A
Sbjct: 883 A 883
Score = 209 bits (533), Expect = 6e-54
Identities = 128/427 (29%), Positives = 188/427 (44%), Gaps = 82/427 (19%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG + G +SP +P Y + +CVW++ +I L F +L + +C YD+V
Sbjct: 619 ACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFV 678
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
EVR G A L GRFCGS+ PE I S + + VEF+S + +GF A +
Sbjct: 679 EVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAK 738
Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
EA C + G + SPN+PD Y
Sbjct: 739 DNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPS 798
Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
+ C W I + G V LTF FEIE+H CAYD+LE+ DG + ++GR+CG +KPD
Sbjct: 799 RRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDP 858
Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
++ S ++L+F SD S+ + GF + S +C
Sbjct: 859 TVASGSSMFLRFYSDASVQRKGF------------------------QAVHSTECGGRLK 894
Query: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
E+ + A G YP C W +VA Y + L F FE
Sbjct: 895 AEVQTKELYSHAQFGD---------------NNYPSEARCDWVIVAEDGYGVELTFRTFE 939
Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
E C YD++E G + + G+FCGS E I S +++ + F++D+T++KKGF
Sbjct: 940 VEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFH 999
Query: 698 AHFFSEK 704
A + S K
Sbjct: 1000 ARYTSTK 1006
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 1120 bits (2897), Expect = 0.0
Identities = 510/711 (71%), Positives = 604/711 (84%), Gaps = 20/711 (2%)
Query: 27 DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRR-------HTA 79
DYT+D EED +E ++YKDPCKAA F GDIALD+EDL FQ+ + +DL + HT
Sbjct: 34 DYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTT 93
Query: 80 ----------RKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRG---RSRSRRAATSRP 126
++ ++ + N + ++ G ++R RAATSR
Sbjct: 94 GGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRT 153
Query: 127 ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ER+DE+SYIVFTYRPCGCC
Sbjct: 154 ERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCC 213
Query: 187 SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
SYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+RENIQPGQE
Sbjct: 214 SYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQE 273
Query: 247 YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
YNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P + NG++P IGQRTRLS
Sbjct: 274 YNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333
Query: 307 KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
KGDIAQARKLY+CPACGETLQ+S GN SSP +PNGY ++ HC+WR+SVTPGEKI+LNFT+
Sbjct: 334 KGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT 393
Query: 367 LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
+DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + STDSR+W+EFRSSSNWVGKG
Sbjct: 394 MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKG 453
Query: 427 FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
F AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSE +HVGLTFQSFEIERHD
Sbjct: 454 FAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD 513
Query: 487 SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
+CAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KFVSDG++NKAGFA NFFK
Sbjct: 514 NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK 573
Query: 547 EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
E DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEAACGG LTKLNG+IT+PG
Sbjct: 574 EEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPG 633
Query: 607 WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
WPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+VE+ SGL+++SKLHGKFC
Sbjct: 634 WPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC 693
Query: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRGRPHQ 717
G+E PEVITSQ+NNMR+EFKSDNTVSKKGFKAHFFS+K + G H+
Sbjct: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHE 744
Score = 296 bits (757), Expect = 6e-80
Identities = 155/426 (36%), Positives = 225/426 (52%), Gaps = 45/426 (10%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG ++ + G SP YP+ Y CVW+I+V+ + L F S ++ R C YDY+E
Sbjct: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
VRDG +PL GRFCG PE I ST + LW++F S GF A +
Sbjct: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 432 ---------------------------------EAICGGDVKKDYGHIQSPNYPDDYRPS 458
EA CGG + K G I +P +P +Y P+
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641
Query: 459 KVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDI 518
K C+W++ + + + F+ FE+E ++ C YDY+E+ G S S L G++CG E P+ I
Sbjct: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701
Query: 519 KSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGY 578
S + + ++F SD +++K GF +FF + DECS+ N GGC+ C+NT+GSY C C G+
Sbjct: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQHECVNTMGSYMCQCRNGF 760
Query: 579 ELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
L +K C EA C + +G ITSP WP +YP K C W++ A +RI L F FE
Sbjct: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820
Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
E + C YD +EV G T S + G+ CG++ P+ + + N M V F SD +V +KGF+
Sbjct: 821 IEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
Query: 698 AHFFSE 703
A +E
Sbjct: 881 ATHSTE 886
Score = 209 bits (533), Expect = 6e-54
Identities = 128/429 (29%), Positives = 192/429 (44%), Gaps = 82/429 (19%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG L G ++P +P Y + +CVW++ +I + F +L + +C YDYV
Sbjct: 617 ACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYV 676
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
E+ G ++ L G+FCG+++PE I S + + +EF+S + KGF A +
Sbjct: 677 EIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736
Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
EA C + G I SPN+PD Y
Sbjct: 737 DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796
Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
K C W I + G + L F FEIE+H CAYD+LEV DG +E S ++GR CG + PD
Sbjct: 797 RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP 856
Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
+ +T ++++++FVSD S+ + GF S +C
Sbjct: 857 LVATGNKMFVRFVSDASVQRKGFQATH------------------------STECGGRLK 892
Query: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
E P A G YP +C W LV+ R+ L F FE
Sbjct: 893 AESKPRDLYSHAQFGD---------------NNYPGQVDCEWLLVSERGSRLELSFQTFE 937
Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
E C YD+VE+ GL + + G+FCGS PE I S +++ + F +D+T++KKGF
Sbjct: 938 VEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFH 997
Query: 698 AHFFSEKRP 706
+ S + P
Sbjct: 998 IRYKSIRYP 1006
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 204 bits (519), Expect = 2e-52
Identities = 128/383 (33%), Positives = 179/383 (46%), Gaps = 49/383 (12%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG Q +G SP YP+ Y ++ C W I V +++LNFT DL C Y
Sbjct: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567
Query: 382 VRDGFWRKAPLRGRFCG-SKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV- 439
DG R CG +L PIVS+ + L++ F+S + +GF A + CGG +
Sbjct: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625
Query: 440 KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGF-HVGLTFQSFEIERHDSCAYDYLEVRDG 498
+ + SP +P +Y ++ C W IQ H+ L+F FE+ER +CA D++E+ DG
Sbjct: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685
Query: 499 HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
E + L GRYCG + P I S SS L L+FVSD SI+ GF V
Sbjct: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASV---------- 1735
Query: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
+ACGG G SPG+P YPPN C+
Sbjct: 1736 ------------------------------SACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765
Query: 619 WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQY 678
W +V+ R+ L F F+ E + C DFVE+R G A L G++CG+ P +S
Sbjct: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824
Query: 679 -NNMRVEFKSDNTVSKKGFKAHF 700
+ + V F SD + S GF+A F
Sbjct: 1825 GHTLWVRFISDGSGSGTGFQATF 1847
Score = 203 bits (517), Expect = 4e-52
Identities = 139/488 (28%), Positives = 213/488 (43%), Gaps = 80/488 (16%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY-DY 379
AC + D G F+SP +PN Y + C++RI+V G+ I ++FT+ L + +Y D+
Sbjct: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106
Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---CG 436
+E+RDG + K+PL G F GS LP I+S ++LW++F+S GF A ++ CG
Sbjct: 1107 LEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCG 1166
Query: 437 GDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVR 496
G++ G SPNYP Y S C W ++ S G L F+ F +E H +C DYL V
Sbjct: 1167 GNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVY 1226
Query: 497 DGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF------------ 544
DG S +S L+ + CG EKP I+S+ +++K +D GF +
Sbjct: 1227 DGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVNQ 1286
Query: 545 -FKEVDECSRPNRGGCEQRCLNTLGS----------------YKCSCDPGY-ELAPDKRR 586
+ ++ PN Q C T+ + + +C Y EL R+
Sbjct: 1287 TYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQ 1346
Query: 587 CEAACG----------------------------GF------------LTKLNGSITSPG 606
CG GF L+ GS +SPG
Sbjct: 1347 MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPG 1406
Query: 607 WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
+P YPPNK CIW + I L F+ E + C +D +E+ G S + C
Sbjct: 1407 FPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLC 1466
Query: 667 GSEKPE---VITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPA---LQPPRGRPHQLKF 720
PE ++S N + + FK+D +++ +GF A + + Q P G H +
Sbjct: 1467 TQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNY 1526
Query: 721 RVQKRNRT 728
R+ T
Sbjct: 1527 PSPYRSNT 1534
Score = 197 bits (502), Expect = 2e-50
Identities = 130/410 (31%), Positives = 192/410 (46%), Gaps = 55/410 (13%)
Query: 303 TRLSKGDIAQARKLYKCPACG-ETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPG-EKI 360
+R ++G AQ R+ ACG L S SSP +P Y + +C W I P I
Sbjct: 1606 SRQNRGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHI 1660
Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
L+FT +L RS C D+VE+ DG APLRGR+CG+ +P PI S S L + F S S
Sbjct: 1661 TLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDS 1720
Query: 421 NWVGKGFFAVYEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF 477
+ GF A CGG G SP YPD Y P+ C+W I S G + L+F
Sbjct: 1721 SISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSF 1780
Query: 478 QSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS-TSSRLWLKFVSDGSIN 536
SF++E C+ D++E+R+G++ + L+GRYCG P + S LW++F+SDGS +
Sbjct: 1781 ISFQLEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGS 1839
Query: 537 KAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLT 596
GF F K N +G++
Sbjct: 1840 GTGFQATFMKIFGND-------------NIVGTH-------------------------- 1860
Query: 597 KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLT 656
G + SP WP+ YP N N W + + + + + E C YD + + G +
Sbjct: 1861 ---GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPS 1917
Query: 657 ADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706
++L G +CG++ E +S N++ F SD+++S KGF +F+ P
Sbjct: 1918 IHARLIGAYCGTQ-TESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAP 1966
Score = 192 bits (487), Expect = 1e-48
Identities = 123/384 (32%), Positives = 179/384 (46%), Gaps = 56/384 (14%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L +TG+FSSP +PN Y + C+W I PG I L D+ C +D +E
Sbjct: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
Query: 382 VRDGFWRKAPLRGRFCGSKLPE---PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---C 435
+ G +P + C + PE + ST + L + F++ + G+GF A ++A+ C
Sbjct: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
Query: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
GG + G I SPNYP YR + C W I+V V L F F++E DSC Y
Sbjct: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY--- 1567
Query: 496 RDGHSESSTLIGRYCGYEK-PDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
DG S + + + R CG E+ + I S+ + L+L+F S S GF F
Sbjct: 1568 -DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQF---------- 1616
Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWPKEYPP 613
ACGG LT +++SP +P YP
Sbjct: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643
Query: 614 NKNCIWQLVA-PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE 672
N+NC W + A P I+L F FE E + C DFVE+ G D+ L G++CG++ P
Sbjct: 1644 NQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPH 1703
Query: 673 VITSQYNNMRVEFKSDNTVSKKGF 696
ITS + + + F SD+++S GF
Sbjct: 1704 PITSFSSALTLRFVSDSSISAGGF 1727
Score = 189 bits (479), Expect = 1e-47
Identities = 124/386 (32%), Positives = 181/386 (46%), Gaps = 48/386 (12%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACGE L +STG SP +PN Y ++C W I V P I L F + L C DY+
Sbjct: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-----C 435
EV D + GR+CG +P + S+ + L + F + S+ +GF YEAI C
Sbjct: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
Query: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY-DYLE 494
D D G SPN+P++Y + CI+RI V G + + F +F +E Y D+LE
Sbjct: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
+RDG E S L+G + G P I S S++LWLKF SD ++GF+ +
Sbjct: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWD--------- 1159
Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
GS CGG LT +G+ SP +P Y +
Sbjct: 1160 -------------GS------------------STGCGGNLTTSSGTFISPNYPMPYYHS 1188
Query: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
C W L + L+F F E + C D++ V G +++S L + CG EKP +I
Sbjct: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248
Query: 675 TSQYNNMRVEFKSDNTVSKKGFKAHF 700
S ++M ++ ++D +GFKA +
Sbjct: 1249 RSSGDSMFIKLRTDEGQQGRGFKAEY 1274
Score = 184 bits (466), Expect = 3e-46
Identities = 117/395 (29%), Positives = 186/395 (47%), Gaps = 49/395 (12%)
Query: 318 KCPACGETLQ----DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS-LDLYRS 372
K ACG + DS G +SP +P+ Y H C+W ++ P +I L F D+ +
Sbjct: 2213 KSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVT 2272
Query: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
C +Y+E+RDG AP+ +FCG+ LP S+ +++ FRS ++ GF A Y
Sbjct: 2273 PNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS 2332
Query: 433 -AICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
A CGG V G ++S +P YR + C W +Q G ++ ++F+ F ++ C
Sbjct: 2333 IAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEK 2392
Query: 491 DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
D++E+ D H+ S ++GRYCG PD I ++S+ ++FV+DGS+ +GF + F ++E
Sbjct: 2393 DFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE 2451
Query: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
CGG L G+ TSP +P
Sbjct: 2452 ----------------------------------------CGGDLQGSIGTFTSPNYPNP 2471
Query: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-E 669
P + C W++ AP RI+L F+ + C + V V +G+ ++S K C S
Sbjct: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
Query: 670 KPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704
I S N M+V F +D + GF A + S +
Sbjct: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSE 2566
Score = 183 bits (465), Expect = 4e-46
Identities = 124/396 (31%), Positives = 184/396 (46%), Gaps = 57/396 (14%)
Query: 321 ACGETLQ--DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
ACG L+ D+ SP +P+ YS + C W I P + LN SLD+ R C YD
Sbjct: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035
Query: 379 YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
+ +RDG A CG ++P PI ST +++ F S S+ GF A + CGG
Sbjct: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095
Query: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDSCAY--DYLEV 495
+ D G I SP YP+ Y + C W + V G + + F Q F+I DS DYL +
Sbjct: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155
Query: 496 RDGHSESSTLI------GRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549
R+G S + G +CG + ++ ++++++F+SD S GF + +
Sbjct: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY----- 2210
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFL----TKLNGSITSP 605
E + L ACGG + G +TSP
Sbjct: 2211 ----------EAKSL-------------------------ACGGNVYIHDADSAGYVTSP 2235
Query: 606 GWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
P YPP+ +CIW L AP + RI LQF D F+ E C +++E+R G+ +D+ + K
Sbjct: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295
Query: 665 FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
FCG+ P S M + F+SDN+ + GFKA +
Sbjct: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331
Score = 182 bits (461), Expect = 1e-45
Identities = 127/396 (32%), Positives = 180/396 (45%), Gaps = 50/396 (12%)
Query: 311 AQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY 370
A R +Y+ ACG+ L G SP +PN Y C W I + I+LNFT ++
Sbjct: 807 ASFRAVYQV-ACGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG 864
Query: 371 RSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
S C DYVE+ +P ++CG+ +P I S + L+V F SS+ GF A
Sbjct: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
Query: 431 YEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS 487
+ A CG + + G IQSP +P+ Y C W I V + L F++F +E H +
Sbjct: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
Query: 488 CAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE 547
C DYLEV D SE+S +GRYCG P + S+ + L L FV+D + GF +N+
Sbjct: 985 CTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY--- 1039
Query: 548 VDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGW 607
+ AC T G+ TSP +
Sbjct: 1040 -----------------------------------EAISAATACLQDYTDDLGTFTSPNF 1064
Query: 608 PKEYPPNKNCIWQLVAPTQYRISLQFDFFETE---GNDVCKYDFVEVRSGLTADSKLHGK 664
P YP N CI+++ T I++ F F E GN DF+E+R G S L G
Sbjct: 1065 PNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYT--DFLEIRDGGYEKSPLLGI 1122
Query: 665 FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
F GS P I S N + ++FKSD ++ GF A++
Sbjct: 1123 FYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW 1158
Score = 179 bits (454), Expect = 8e-45
Identities = 128/397 (32%), Positives = 181/397 (45%), Gaps = 36/397 (9%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG T + G F+SP YP+ Y ++ CVW I +PG ++ L+F S L S+ C D+V
Sbjct: 1737 ACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFV 1796
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVS-TDSRLWVEFRSSSNWVGKGFFAVYEAICGGD- 438
E+R+G L GR+CG+ P S LWV F S + G GF A + I G D
Sbjct: 1797 EIREGN-ATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDN 1855
Query: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG 498
+ +G + SP +P++Y + W + V+ V +IE +C YD L + DG
Sbjct: 1856 IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG 1915
Query: 499 HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
S + LIG YCG + + ST + L F SD SI+ GF + +F VD
Sbjct: 1916 PSIHARLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFA-VD--------- 1964
Query: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSIT--SPGWPKEYPPNKN 616
L T+ PG ACGGFL + + SPGWP Y +
Sbjct: 1965 APDGVLPTIA-------PG------------ACGGFLRTGDAPVFLFSPGWPDSYSNRVD 2005
Query: 617 CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
C W + AP + L + E + C YD + +R G ++ CG E P I S
Sbjct: 2006 CTWLIQAPDS-TVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRS 2064
Query: 677 QYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
M + F SD++V++ GF A F L RG
Sbjct: 2065 TGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADRG 2101
Score = 171 bits (433), Expect = 2e-42
Identities = 109/389 (28%), Positives = 166/389 (42%), Gaps = 53/389 (13%)
Query: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDY 379
P CG L G+ SP YP Y CVW + +P + F +L L C DY
Sbjct: 588 PECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDY 647
Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY-----EAI 434
+E+RDG + PL G+FC + P+ +T + F S S +GF Y +
Sbjct: 648 LEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLR 707
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG+ G + P + ++ C++ ++ +G + + F E++ + +Y+E
Sbjct: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
VRDG TL+G+ CG IKS ++ +W++F D S+ KA F +
Sbjct: 768 VRDGE----TLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY---------- 813
Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
+ ACG LT G I SP +P YP
Sbjct: 814 ---------------------------------QVACGDELTG-EGVIRSPFFPNVYPGE 839
Query: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
+ C W + P I L F FE + C+ D+VE+ S S + K+CG++ P I
Sbjct: 840 RTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFI 899
Query: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSE 703
TS YN + V F ++ GF A F +E
Sbjct: 900 TSVYNFLYVTFVKSSSTENHGFMAKFSAE 928
Score = 171 bits (432), Expect = 3e-42
Identities = 118/410 (28%), Positives = 178/410 (43%), Gaps = 49/410 (11%)
Query: 292 VNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWR 351
V+GV + TRL G + Q + CGE+L G+FS GY ++C W
Sbjct: 448 VDGVDSFSCECTRLWTGALCQVPQ----QVCGESLSGINGSFSYRSPDVGYVHDVNCFWV 503
Query: 352 ISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSR 411
I G+ + + FT L C +++++V DG A GRFCGS LP ++S+D+
Sbjct: 504 IKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNA 563
Query: 412 LWVEFRSSSNWVGKGFFAVYEAI---CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVS 468
L+ S G+GF +E CGG + YG I+SP YP +Y P + C+W + S
Sbjct: 564 LYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTS 623
Query: 469 EGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLK 528
V TF + +E HD C DYLE+RDG L+G++C +++T +
Sbjct: 624 PDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIH 683
Query: 529 FVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
F SD I+ GF + Y +P R
Sbjct: 684 FHSDSQISDQGFHIT----------------------------------YLTSPSDLR-- 707
Query: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
CGG T G + P + + C++ + P +I + F E + ++
Sbjct: 708 --CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNY 765
Query: 649 VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA 698
+EVR G T L GK CG+ I S N++ + FK D +V K F+A
Sbjct: 766 IEVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRA 811
Score = 169 bits (428), Expect = 8e-42
Identities = 124/403 (30%), Positives = 179/403 (44%), Gaps = 54/403 (13%)
Query: 322 CGETLQDST-GNFSSPEYPN--GYSAHMHCVWRISVTPGE---KIILNFTSLDLYRSRLC 375
CG +L ++ GNF+SP Y YS +++C W +S P + I ++F L + C
Sbjct: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS-NPNQGNSSISIHFEDFYLESHQDC 2628
Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
+D +E R G PL R CG P P+V S++W+ F ++ GF A Y
Sbjct: 2629 QFDVLEFRVGD-ADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFT 2687
Query: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
CGG D G I SPNYP+ Y C ++ +G + LTF F+IE H +CA+D +
Sbjct: 2688 DCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSV 2747
Query: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
VR+G S S +IG+YCG P I+S S++L + F SD S+ GF + +
Sbjct: 2748 TVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQ------ 2801
Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
TLG CGG NG+I SP WP+ +P
Sbjct: 2802 ------------TLG----------------------CGGIFHSDNGTIRSPHWPQNFPE 2827
Query: 614 NKNCIWQLVAPTQYRISLQFD--FFETEGNDVCKYDFVEVRSGL-TADSKLHGKFCGSEK 670
N C W + + + FD F G+ C+ FV+V +G D L CG+
Sbjct: 2828 NSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVA 2887
Query: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
P + + N F+S + +GF A F S P G
Sbjct: 2888 PGPVITPSNTFTAVFQSQEAPA-QGFSASFVSRCGSNFTGPSG 2929
Score = 163 bits (413), Expect = 5e-40
Identities = 115/390 (29%), Positives = 174/390 (44%), Gaps = 49/390 (12%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY-RSRL---CWY 377
CG +G SP YP Y +M+C + I P ++L F S L RS + C
Sbjct: 2920 CGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVN 2979
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
D V + G+ + CG ++P P+ L + F S+ GF Y I CG
Sbjct: 2980 DGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCG 3038
Query: 437 GDVKKDYGHIQSPNYP-DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
G G I SP Y DY C++ I VS+ + L F F++ SC++DYL +
Sbjct: 3039 GVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAI 3098
Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN 555
DG + S L+G++CG ++P ++KS+++ + L F +D G+ ++F
Sbjct: 3099 YDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSF----------- 3147
Query: 556 RGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE--YPP 613
TLG + CGG+LT N + SP Y
Sbjct: 3148 --------RQTLGP------------------QQGCGGYLTGSNNTFASPDSDSNGMYDK 3181
Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDV---CKYDFVEVRSGLTADSKLHGKFCGSEK 670
N NC+W ++AP I L F+ F E C YD+V++ G + ++ L G FCGS
Sbjct: 3182 NLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTV 3241
Query: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
P S N + V+F SD T+ ++GF A +
Sbjct: 3242 PAPFISSGNFLTVQFISDLTLEREGFNATY 3271
Score = 159 bits (402), Expect = 9e-39
Identities = 105/379 (27%), Positives = 163/379 (43%), Gaps = 47/379 (12%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG D G PE ++ CV+ + GE+I +NFT ++L +Y+E
Sbjct: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
VRDG L G+ CG+ I S + +W+ F+ ++ F AVY+ CG ++
Sbjct: 768 VRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTG 823
Query: 442 DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSE 501
+ G I+SP +P+ Y + C W I + + L F FEI C DY+E+
Sbjct: 824 E-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSIL 882
Query: 502 SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ 561
S +YCG + P I S + L++ FV S GF F E
Sbjct: 883 GSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE-------------- 928
Query: 562 RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
+ ACG LT+ G+I SPG P YP NC W +
Sbjct: 929 --------------------------DLACGEILTESTGTIQSPGHPNVYPHGINCTWHI 962
Query: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNM 681
+ + I L F+ F E + C D++EV T G++CG P +TS N++
Sbjct: 963 LVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSL 1020
Query: 682 RVEFKSDNTVSKKGFKAHF 700
+ F +D+ ++ +GF ++
Sbjct: 1021 MLVFVTDSDLAYEGFLINY 1039
Score = 157 bits (396), Expect = 4e-38
Identities = 111/395 (28%), Positives = 173/395 (43%), Gaps = 70/395 (17%)
Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
G +SP +P Y + + W ++V + +D+ + C+YD + + DG A
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920
Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI--------------CG 436
L G +CG++ E ST + L F S S+ GKGF + A+ CG
Sbjct: 1921 RLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACG 1979
Query: 437 GDVKKDYGHIQ--SPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
G ++ + SP +PD Y C W IQ + V L S +IE H +CAYD L
Sbjct: 1980 GFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLV 2038
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
+RDG + + + CG E P I+ST ++++F SD S+ +AGF +F K
Sbjct: 2039 IRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK-------- 2090
Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
+CGG+L G ITSP +P+ YP N
Sbjct: 2091 -----------------------------------SCGGYLHADRGIITSPKYPETYPSN 2115
Query: 615 KNCIWQLVAPTQYRISLQFD--FFETEGNDVCKY-DFVEVRSGLTADSKL------HGKF 665
NC W ++ + I++ F+ F G+ C D++ +R+G S +G F
Sbjct: 2116 LNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHF 2175
Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
CGS + + N M V+F SD++ +GFK +
Sbjct: 2176 CGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
Score = 155 bits (392), Expect = 1e-37
Identities = 110/387 (28%), Positives = 171/387 (44%), Gaps = 53/387 (13%)
Query: 322 CGETLQDSTGNFSSPEYPNG--YSAHMHCVWRISVTPGEKII-LNFTSLDLYRS---RLC 375
CG L S F+SP+ + Y +++CVW I + P K+I L F + L + + C
Sbjct: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVW-IIIAPVNKVIHLTFNTFALEAASTRQRC 3215
Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
YDYV++ DG A L G FCGS +P P +S+ + L V+F S +GF A Y +
Sbjct: 3216 LYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMD 3275
Query: 435 --CGGDVKKDY--GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
CGG + +I SPN D P +C W I V +T + ++ D C
Sbjct: 3276 MPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQ 3334
Query: 491 DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
+YL+++D ++CG SS + + ++F ++ +
Sbjct: 3335 NYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIAD 3394
Query: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
C+R K G++ SPGWP
Sbjct: 3395 CNRDYH----------------------------------------KAFGNLRSPGWPDN 3414
Query: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Y +K+C L AP + ISL F E + C+ DF+EVR+G ++S L GK+CG+
Sbjct: 3415 YDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLL 3474
Query: 671 PEVITSQYNNMRVEFKSDNTVSKKGFK 697
P + SQ N + + FKSD+ S +G++
Sbjct: 3475 PNPVFSQNNELYLRFKSDSVTSDRGYE 3501
Score = 148 bits (373), Expect = 2e-35
Identities = 105/395 (26%), Positives = 171/395 (43%), Gaps = 52/395 (13%)
Query: 317 YKCPACGETLQDSTGNFSSPEYPN-GYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Y CG + +G S +P Y ++ C W + G + ++F +L S C
Sbjct: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
D+VE+ D + GR+CG+ +P+ I ++ + V F + + GF +E+
Sbjct: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
Query: 435 --CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
CGGD++ G SPNYP+ ++C WRI EG + L F + + H SC ++
Sbjct: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509
Query: 493 LEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
+ V +G +S + + C ++IKS+ + + + F +DGS GF ++ D
Sbjct: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567
Query: 552 SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NGSITSPGWP-- 608
A CGG L G+ TSPG+
Sbjct: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590
Query: 609 KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
+ Y N NC W L P Q IS+ F+ F E + C++D +E R G AD L + C
Sbjct: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649
Query: 667 GSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHF 700
G KP + + Y+ + + F ++ V GF A +
Sbjct: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
Score = 148 bits (373), Expect = 2e-35
Identities = 110/388 (28%), Positives = 167/388 (43%), Gaps = 54/388 (13%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG LQ S G F+SP YPN C WRI+ G +I L F +L L C ++V
Sbjct: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
Query: 382 VRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY----EAICG 436
V +G +P + C S + I S+ + + V F + + GF A Y +A+CG
Sbjct: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCG 2571
Query: 437 GDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCAYD 491
G + G+ SP Y +Y + C W + + + F+ F +E H C +D
Sbjct: 2572 GSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD 2631
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
LE R G ++ L+ R CG KP + S++W+ FV++ + GF +
Sbjct: 2632 VLEFRVGDADGP-LMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------ 2684
Query: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
CGG +G ITSP +P
Sbjct: 2685 ------------------------------------SFTDCGGIQIGDSGVITSPNYPNA 2708
Query: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Y +C L AP + I+L F F+ E + C +D V VR+G + +S + G++CG+
Sbjct: 2709 YDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSN 2768
Query: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKA 698
P I S N + V F SD+++ GF A
Sbjct: 2769 PRTIQSGSNQLVVTFNSDHSLQGGGFYA 2796
Score = 137 bits (344), Expect = 5e-32
Identities = 103/372 (27%), Positives = 161/372 (43%), Gaps = 49/372 (13%)
Query: 332 NFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAP 391
N SSP + C W I P +++ + +L L S+ C +Y++++D
Sbjct: 3290 NISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQL-TSQDCTQNYLQLQDSPQGHGN 3348
Query: 392 LRGRFCGSKLPEPIV--STDSRLWVEFRSSS-NWVGKGFFAVYEAICGGDVKKDYGHIQS 448
R +FCG V S+ S V F+S N + F A C D K +G+++S
Sbjct: 3349 SRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRS 3408
Query: 449 PNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGR 508
P +PD+Y K C + + + L F S IE C D+LEVR+G + +S L+G+
Sbjct: 3409 PGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGK 3468
Query: 509 YCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLG 568
YCG P+ + S ++ L+L+F SD + G+ E+ S P
Sbjct: 3469 YCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY------EIIWTSSP-------------- 3508
Query: 569 SYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYR 628
+ CGG L GS TSPG+P YP N C W LVAP
Sbjct: 3509 --------------------SGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRL 3548
Query: 629 ISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSE---KPEVITSQYNNMRVEF 685
+++ F F + C +++ + G A S G +CG + P V +S N + ++F
Sbjct: 3549 VTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASS--NQVFIKF 3606
Query: 686 KSDNTVSKKGFK 697
+D F+
Sbjct: 3607 HADYARRPSAFR 3618
Score = 129 bits (325), Expect = 7e-30
Identities = 103/400 (25%), Positives = 164/400 (41%), Gaps = 56/400 (14%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR--LCWYDY 379
CG G SP +P + + C W + + ++F + L S C +
Sbjct: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
Query: 380 VEVRDGFWR-KAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
V+V G L CG+ P P+++ + F+S +GF A + + CG +
Sbjct: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVSRCGSN 2923
Query: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----SCAYDYLE 494
G+I SPNYP Y + C + I+ + V LTF SF +E SC D +
Sbjct: 2924 FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVH 2983
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
+ G+S ST CG E P + + + + L F S+ I GF
Sbjct: 2984 IIRGYSVMSTPFATVCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKF------------ 3030
Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
SY+ +CGG +G ITSP + +YP
Sbjct: 3031 --------------SYRI----------------ISCGGVFNFSSGIITSPAYSYADYPN 3060
Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
+ +C++ + I L+F F+ + C +D++ + G L GKFCGS++P
Sbjct: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
+ S N+M + FK+D+ + KG+K F R L P +G
Sbjct: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSF----RQTLGPQQG 3156
Score = 125 bits (315), Expect = 1e-28
Identities = 101/391 (25%), Positives = 155/391 (39%), Gaps = 55/391 (14%)
Query: 317 YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
Y CG +G +SP YPN Y + HC + G I L F+ D+ C
Sbjct: 2684 YSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCA 2743
Query: 377 YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
+D V VR+G ++P+ G++CG+ P I S ++L V F S + G GF+A +
Sbjct: 2744 WDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTL 2803
Query: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHD-SCAYD 491
CGG D G I+SP++P ++ + C W + H+ ++F +F I D C
Sbjct: 2804 GCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNS 2863
Query: 492 YLEVRDGHSE-SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
+++V G E L+ CG P + + S+ F S GF+ +F
Sbjct: 2864 FVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFV----- 2917
Query: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
+ CG T +G I SP +PK+
Sbjct: 2918 --------------------------------------SRCGSNFTGPSGYIISPNYPKQ 2939
Query: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDV----CKYDFVEVRSGLTADSKLHGKFC 666
Y N NC + + A + L F F E C D V + G + S C
Sbjct: 2940 YDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVC 2999
Query: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
G E P +T + + F S+ ++ GFK
Sbjct: 3000 GDEMPAPLTIA-GPVLLNFYSNEQITDFGFK 3029
Score = 122 bits (306), Expect = 1e-27
Identities = 94/385 (24%), Positives = 161/385 (41%), Gaps = 53/385 (13%)
Query: 317 YKCPACGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Y+ +CG S+G +SP Y Y MHC++ I+V+ + I L F+ D+ S C
Sbjct: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091
Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
+DY+ + DG PL G+FCGSK P + S+++ + + F++ S KG+ +
Sbjct: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
Query: 435 -----CGGDVKKDYGHIQSPNYPDD--YRPSKVCIWRIQVSEGFHVGLTFQSFEIE---R 484
CGG + SP+ + Y + C+W I + LTF +F +E
Sbjct: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211
Query: 485 HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
C YDY+++ DG SE++ L G +CG P S+ + L ++F+SD ++ + GF +
Sbjct: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
Query: 545 FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 604
C G+Y + P +I+S
Sbjct: 3272 TIMDMPCG---------------GTYNATWTP-----------------------QNISS 3293
Query: 605 PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
P P C W + +P ++ + + D C ++++++ +
Sbjct: 3294 PNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQ 3352
Query: 665 FCG--SEKPEVITSQYNNMRVEFKS 687
FCG + V S + V FKS
Sbjct: 3353 FCGRNASAVPVFYSSMSTAMVIFKS 3377
Score = 117 bits (293), Expect = 4e-26
Identities = 67/232 (28%), Positives = 113/232 (48%), Gaps = 4/232 (1%)
Query: 317 YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
Y+ C + GN SP +P+ Y C ++ I L F SL + S C
Sbjct: 3390 YQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECR 3449
Query: 377 YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
D++EVR+G +PL G++CG+ LP P+ S ++ L++ F+S S +G+ ++ +
Sbjct: 3450 NDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPS 3509
Query: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
CGG + D G SP YP Y + C W + G V + F I+ C +YL
Sbjct: 3510 GCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYL 3569
Query: 494 EVRDGHSESSTLIGRYCGYEKP-DDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
+ DG + SS G YCG + ++S+++++KF +D + + F + +
Sbjct: 3570 TLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTW 3621
Score = 63.9 bits (154), Expect = 5e-10
Identities = 43/167 (25%), Positives = 77/167 (46%), Gaps = 10/167 (5%)
Query: 542 VNFFKEVDEC-SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEA---ACGGFLTK 597
VN + ++EC S P G C++ + S+ C C + A C+ CG L+
Sbjct: 427 VNCTENINECLSNPCLNG--GTCVDGVDSFSCECTRLWTGA----LCQVPQQVCGESLSG 480
Query: 598 LNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTA 657
+NGS + Y + NC W + + + F FF E D C ++F++V G ++
Sbjct: 481 INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS 540
Query: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704
+ G+FCGS P + S N + S++ + +GF + +++
Sbjct: 541 SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQ 587
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 174 bits (441), Expect = 3e-43
Identities = 117/402 (29%), Positives = 177/402 (44%), Gaps = 53/402 (13%)
Query: 305 LSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNF 364
L G AQA + KC G L +GNFSSP +P Y + C W I V G ++L F
Sbjct: 16 LGPGLQAQAMEGVKC---GGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF 72
Query: 365 TSLDLYRSRLCWYDYVEVRDGFW-RKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
+ DL C +D++E+ +G K L GRFCG P P S+ + V F S +
Sbjct: 73 HAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVA 132
Query: 424 GKGFFAVYEA-ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482
GF A Y+ +CGG + G + SP YP++Y S C W I+ + HV L F F++
Sbjct: 133 SHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
Query: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV 542
E ++ C YDY+ V G T YCG +P + S L + F SD +I GF
Sbjct: 193 EGNEECTYDYVAVLGG--PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
Query: 543 NFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSI 602
+F G C++ + G+
Sbjct: 251 YYFS----------GECQE--------------------------------VYMAMRGNF 268
Query: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV---CKYDFVEVRSGLTAD 658
+SP +P YP N C W + P Y++ + F D E N + C +D + G + +
Sbjct: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328
Query: 659 SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
+ L G +CG P +TS +N + + +D + +++GF +
Sbjct: 329 APLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
Score = 152 bits (383), Expect = 1e-36
Identities = 88/269 (32%), Positives = 131/269 (48%), Gaps = 45/269 (16%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG + G+ SPN+P Y + C W I V+EG V LTF +F++E HD+C++D+LE
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 495 VRDGHS-ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
+ +G S + L+GR+CG P S+ + + F SD + GF+ + K+V
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV----- 144
Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
CGG LT L+G +TSP +P YP
Sbjct: 145 -------------------------------------CGGVLTGLSGVLTSPEYPNNYPN 167
Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
+ C W + A + L F F+ EGN+ C YD+V V G H +CGS +P
Sbjct: 168 SMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHH--YCGSTRPPT 225
Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
+ S + ++V FKSD + +GFKA++FS
Sbjct: 226 LVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 165 bits (418), Expect = 1e-40
Identities = 97/303 (32%), Positives = 156/303 (51%), Gaps = 40/303 (13%)
Query: 434 ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
+CGGDVK + G++ S +P+ Y P+K CIW I V EG V L+F+ F++E H +C YD L
Sbjct: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
Query: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
EV G S +GR+CG +P + + +++ L+ +D GF + + S
Sbjct: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY-------SG 148
Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK-EYP 612
G E + CGG L K G++T+P WP+ +YP
Sbjct: 149 RATSGTEHQF---------------------------CGGRLEKAQGTLTTPNWPESDYP 181
Query: 613 PNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG-LTADSKLHGKFCGSEKP 671
P +C W ++AP I+L F+ F+ E + C+YD V V +G ++ DS+ GKFCG P
Sbjct: 182 PGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVP 241
Query: 672 EVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG----RPHQLKFRVQKRNR 727
I+S+ N + V+F SD +V+ GF A + + R + +G R + K ++ +++
Sbjct: 242 GSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQ 301
Query: 728 TPQ 730
P+
Sbjct: 302 PPE 304
Score = 134 bits (338), Expect = 2e-31
Identities = 74/234 (31%), Positives = 118/234 (50%), Gaps = 11/234 (4%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG ++ +G +S +PN Y + C+W I+V G+ + L+F DL C YD +E
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
V G GRFCG+ P P+V+ +++ + + G+GF Y
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
Query: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
CGG ++K G + +PN+P+ DY P C W I + LTF+ F++E C YD
Sbjct: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
Query: 492 YLEVRDGH-SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
+ V +G S+ S +G++CG P I S + L ++FVSD S+ GF+ ++
Sbjct: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Score = 82.0 bits (201), Expect = 2e-15
Identities = 38/115 (33%), Positives = 60/115 (52%)
Query: 582 PDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN 641
P+ R CGG + +G + S G+P YPPNK CIW + P +SL F F+ E +
Sbjct: 28 PNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELH 87
Query: 642 DVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
C+YD +EV +G + G+FCG+ +P + + N + + +D +GF
Sbjct: 88 PACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF 142
Score = 67.4 bits (163), Expect = 4e-11
Identities = 41/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Query: 322 CGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
CG L+ + G ++P +P Y + C W I P + I L F DL C YD V
Sbjct: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
Query: 381 EVRDGFWRKAPLR-GRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV 439
V +G R G+FCG +P I S + L V+F S + GF A Y+ + G
Sbjct: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
Query: 440 KKDYG 444
K+ G
Sbjct: 279 KEGQG 283
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 155 bits (392), Expect = 1e-37
Identities = 137/499 (27%), Positives = 202/499 (40%), Gaps = 98/499 (19%)
Query: 290 YEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCV 349
Y + G K QR + + R + + CG L+ +G +SP YP Y + HCV
Sbjct: 380 YVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCV 439
Query: 350 WRISVTPGEKII-LNFTSLDLYRSRLCWYDYVEVRDG--FWRKAPLRGRFCGSKLPEPIV 406
W I+ T +K+I L F +L R YD + V D + GS +P+ IV
Sbjct: 440 WVITTTDPDKVIKLAFEEFELERG----YDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495
Query: 407 STDSRLWVEFRSSSNWVGKGFFAVYEAI----CGGDVKKDYGH----------------- 445
S +++W+ +S + GF AVY+ I CG YG
Sbjct: 496 SMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECP 555
Query: 446 ------------IQSPNYPDDYRPSKV--CIWRIQVSEGF-------------------- 471
Q N +PS V C + S G
Sbjct: 556 AAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLI 615
Query: 472 ------HVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRL 525
+ L F F++E +D+L V+D T++G + G E P + S+ +
Sbjct: 616 ISEPGSRIHLIFNDFDVEPQ----FDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIV 671
Query: 526 WLKFVSDGSINKAGFAVNFFK-EVDECSRP------NRGG------------CEQRCLNT 566
L+F SD S GF + + +EC P R G C+ + T
Sbjct: 672 RLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKT 731
Query: 567 LGSYKCSC---DPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA 623
GS +C D + RCEA CGG LT +G I PGWP Y + +C W + A
Sbjct: 732 QGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEA 791
Query: 624 PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRV 683
+ I + FD F+TE N YD +EVR G + S L G++ G++ P+ + S N M +
Sbjct: 792 KPGHSIKITFDRFQTEVN----YDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYL 847
Query: 684 EFKSDNTVSKKGFKAHFFS 702
F +DN+ S GF H+ S
Sbjct: 848 LFTTDNSRSSIGFLIHYES 866
Score = 149 bits (377), Expect = 7e-36
Identities = 104/304 (34%), Positives = 146/304 (48%), Gaps = 36/304 (11%)
Query: 433 AICGGDVKK-DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
A CGG + G I SP YP Y + C W I+ G + L F F+ E A+D
Sbjct: 1276 AECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEM----AHD 1331
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE- 550
L+V DG +S L+ + G P+DI ST + L L+F SD I+K+GF++ F +
Sbjct: 1332 ILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAAT 1391
Query: 551 CSRPN------RGGCEQRCLNTLGSYKCSCDPGYELA-----------------PDKRRC 587
C+ P R G + +T+ CDPGY+L PD C
Sbjct: 1392 CNDPGMPQNGTRYGDSREAGDTV---TFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448
Query: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
AACGG LT G I SP +P+ YPP K C W++ + I+L F F E + YD
Sbjct: 1449 IAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YD 1504
Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPA 707
F+ + G ++S L G + GS+ PE I S N++ + F+SD +V GF F + R A
Sbjct: 1505 FLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREA 1564
Query: 708 LQPP 711
P
Sbjct: 1565 CFDP 1568
Score = 141 bits (356), Expect = 2e-33
Identities = 94/286 (32%), Positives = 147/286 (51%), Gaps = 34/286 (11%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
C G+ + G I SP YP+ Y + CIW+I V+EG + + SF E++ +D LE
Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLE 1858
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD--ECS 552
+ DG ++ +G + G P + STS++L+L F SD S+ AGF + + K V C
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEY-KTVGLAACQ 1917
Query: 553 RPNRGGC-----EQRCLNTLGSYKCSCDPGYELA--------PDKRR--------CEAAC 591
P ++ +N + S++C +PGY L P R C A C
Sbjct: 1918 EPALPSNSIKIGDRYMVNDVLSFQC--EPGYTLQGRSHISCMPGTVRRWNYPSPLCIATC 1975
Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
GG L+ L G I SPG+P YP N +C W++ P Y +QF F TE N +DF+E+
Sbjct: 1976 GGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDFLEI 2031
Query: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
++G S + G+F G++ P + S + + F SD++ +++GFK
Sbjct: 2032 QNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFK 2077
Score = 140 bits (352), Expect = 5e-33
Identities = 92/300 (30%), Positives = 147/300 (49%), Gaps = 40/300 (13%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG++ G I SPNYP Y P K C WR++V+ F + L F+SF +E +YD+
Sbjct: 1450 AACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEP----SYDF 1505
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
L + +G +S LIG Y G + P+ I+S+ + L+L F SD S+ +GFA+ F ++ E C
Sbjct: 1506 LHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREAC 1565
Query: 552 SRP------NRGGCEQRCLNTLGSYKCSCDPGYELAPDKR------------------RC 587
P R G + + +T+ +Y+ CD GY++ C
Sbjct: 1566 FDPGNIMNGTRVGTDFKLGSTI-TYQ--CDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Query: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
A CGG T G + SP +P Y + C++ + P ++ + QF +F+T ND+
Sbjct: 1623 NAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDL---- 1678
Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706
E+ G A ++L GS E + + N + + F + + S +GF HF + P
Sbjct: 1679 -AELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGF--HFVYQAVP 1735
Score = 125 bits (314), Expect = 1e-28
Identities = 88/292 (30%), Positives = 135/292 (46%), Gaps = 32/292 (10%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
EA CGG + G I P +P Y+ S C W I+ G + +TF F+ E + YD
Sbjct: 756 EAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVN----YD 811
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EV 548
LEVRDG + SS LIG Y G + P + ST + ++L F +D S + GF +++ E
Sbjct: 812 TLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLES 871
Query: 549 DECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAAC 591
D C P G + SCDPGY L+ D+ C+A C
Sbjct: 872 DSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALC 931
Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
GG++ +G++ SPG+P YP + NC W + + + F F E + +D++ +
Sbjct: 932 GGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS----HDYLLI 987
Query: 652 RSGLTADSKLHGKFCGSEKPEVI-TSQYNNM--RVEFKSDNTVSKKGFKAHF 700
+ S+ + GS P I + N ++ F SD ++S +GF F
Sbjct: 988 TED-GSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITF 1038
Score = 125 bits (314), Expect = 1e-28
Identities = 93/306 (30%), Positives = 138/306 (45%), Gaps = 35/306 (11%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG + G I SP +P Y + C WRI + G+ + F +F E + +D+
Sbjct: 1973 ATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDF 2028
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
LE+++G +S +IG++ G + P + ST+ + F SD S N+ GF + + E+ C
Sbjct: 2029 LEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNC 2088
Query: 552 SRP---NRGGCEQRCLNTLGSYKCSCDPGYELAPDK----------------RRCEAACG 592
P G + S C PGY L RC+A CG
Sbjct: 2089 PDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCG 2148
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
+T NG+I SPG+P EYP K+CIW + P + + + F +TE + D++ V
Sbjct: 2149 YNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIAVW 2204
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF---KAHFFSEKRPALQ 709
G +S G F G+ E S N + ++F SD S GF H F K+ Q
Sbjct: 2205 DGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD--FSNGGFFVLNFHAFQLKK--CQ 2260
Query: 710 PPRGRP 715
PP P
Sbjct: 2261 PPPAVP 2266
Score = 123 bits (308), Expect = 7e-28
Identities = 118/467 (25%), Positives = 186/467 (39%), Gaps = 101/467 (21%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG TL G SP +P Y ++ C WRIS+ G + F + + +D++E
Sbjct: 1975 CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDFLE 2030
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----C-- 435
+++G + +P+ G+F G+ LP ++ST + F S + +GF Y+A C
Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPD 2090
Query: 436 ------GGDVKKDYGHIQSP--------------------------NYP----------- 452
G + DY QS NYP
Sbjct: 2091 PPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYN 2150
Query: 453 --------------DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG 498
D+Y K CIW I V G V + F + E DY+ V DG
Sbjct: 2151 VTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTE----AVNDYIAVWDG 2206
Query: 499 HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSRPNRG 557
++S +G + G + S+++++ LKF SD S N F +NF ++ +C P
Sbjct: 2207 PDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS-NGGFFVLNFHAFQLKKCQPPPAV 2265
Query: 558 GCEQRCLN----TLGSY-KCSCDPGYELA----------------PDKRRCEAAC--GGF 594
+ +G + K C PGY L CEA C
Sbjct: 2266 PQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQCPANEV 2325
Query: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
T +G I SPG+P Y ++ C W + Y I++ D F++E ++D +EV G
Sbjct: 2326 RTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEK----QFDALEVFDG 2381
Query: 655 LTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHF 700
+ S L G+ + TS+ N + + + +D+ SKKGFK +
Sbjct: 2382 SSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRY 2428
Score = 118 bits (296), Expect = 2e-26
Identities = 94/294 (31%), Positives = 129/294 (43%), Gaps = 36/294 (12%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG V+ G I+SP +P Y C W I E + L+F +F +E +D L
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF-AVNFFKEVDECSR 553
V DG + L R G++ P I ST S L L F +D +++ GF A+ C
Sbjct: 88 VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147
Query: 554 PN---RGGCEQRCLNTLGSYKCSCDPGYEL----------APDKR----------RCEAA 590
P +G N + SC PGY L +P R E A
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGA 207
Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
CGG L + SI+SP +P EY N +C W ++A I+L F F+ E YDF+E
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFLE 263
Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704
+ SG A S G P + S N +R+ F SD+ +KGF A F +K
Sbjct: 264 I-SGTEAPSIW---LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKK 313
Score = 103 bits (256), Expect = 7e-22
Identities = 81/306 (26%), Positives = 129/306 (42%), Gaps = 37/306 (12%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG G + SPNYP +Y ++C++ I V + F V F F+ + D
Sbjct: 1624 APCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQ-----TALNDL 1678
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
E+ DG + L+ G + + +TS+++ L+F + + GF ++ V
Sbjct: 1679 AELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHF-VYQAVPRT 1737
Query: 552 SRPNRGGC-EQRCLNTLGS-------YKCSCDPGYELAPDKR------------------ 585
S E R +GS + C+PGY L
Sbjct: 1738 SDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIP 1797
Query: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
C C G T+ G+I SPG+P+ Y N NCIW+++ I +Q F TE N
Sbjct: 1798 SCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN---- 1853
Query: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKR 705
+D +E+ G + G F G+ P ++ S N + + F+SD +V+ GF + +
Sbjct: 1854 WDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGL 1913
Query: 706 PALQPP 711
A Q P
Sbjct: 1914 AACQEP 1919
Score = 96.7 bits (239), Expect = 7e-20
Identities = 81/295 (27%), Positives = 132/295 (44%), Gaps = 34/295 (11%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
+A+CGG ++ G + SP +PD Y S C W I+VS G V + F +F +E ++D
Sbjct: 928 DALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE----SSHD 983
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
YL + + S S + R G P IK+ + L+F+SD SI+ GF + F + +
Sbjct: 984 YLLITEDGSFSEP-VARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYD 1042
Query: 548 VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
++ C P +R G S SC GY L + RC
Sbjct: 1043 LEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102
Query: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
A CG + G++ SP +P Y N CI+++ I L+ F+ D K
Sbjct: 1103 AECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLK--- 1159
Query: 649 VEVRSGLTADSKLHGKFCGSE-KPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
V G + S+ G F +E ++ S N++ +EF ++ + + +GF+ + S
Sbjct: 1160 --VYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTS 1212
Score = 93.2 bits (230), Expect = 8e-19
Identities = 86/340 (25%), Positives = 136/340 (40%), Gaps = 71/340 (20%)
Query: 418 SSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF 477
+ ++W F E CGG ++ I SP++P +Y + C W I G + L F
Sbjct: 191 NGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVF 250
Query: 478 QSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINK 537
F++E YD+LE+ + S L G P + S+ + L L F SD + +
Sbjct: 251 TDFQLEE----GYDFLEISGTEAPSIWL----TGMNLPSPVISSKNWLRLHFTSDSNHRR 302
Query: 538 AGFAVNF--FKEVDECSR-----PNRGGCEQRCLNTLG---------------------- 568
GF F K ++ SR P++ G + + + G
Sbjct: 303 KGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAG 362
Query: 569 --------SYKCSCDPGYELAPDKR------------------RCEA-ACGGFLTKLNGS 601
+ + SC+ Y L K C A CG L +G
Sbjct: 363 SDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGV 422
Query: 602 ITSPGWPKEYPPNKNCIWQLVAPTQYR-ISLQFDFFETEGNDVCKYDFVEV-RSGLTADS 659
ITSP +P +Y N +C+W + + I L F+ FE E YD + V +G D+
Sbjct: 423 ITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDTLTVGDAGKVGDT 478
Query: 660 K-LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA 698
+ + GS P++I S N M + +SD+++ GFKA
Sbjct: 479 RSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKA 518
Score = 66.6 bits (161), Expect = 8e-11
Identities = 40/110 (36%), Positives = 57/110 (51%), Gaps = 5/110 (4%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG L G SP YP Y C WR+ V P I L F S ++ S YD++
Sbjct: 1451 ACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YDFL 1506
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
+ +G +PL G + GS+ PE I S+ + L++ FRS ++ VG FA+
Sbjct: 1507 HIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDAS-VGLSGFAI 1555
Score = 65.9 bits (159), Expect = 1e-10
Identities = 39/112 (34%), Positives = 58/112 (51%), Gaps = 8/112 (7%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG TL+ ++ + SSP +P+ Y + C W I PG+ I L FT L YD++
Sbjct: 207 ACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFL 262
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
E+ +AP G LP P++S+ + L + F S SN KGF A ++
Sbjct: 263 EISG---TEAPSIW-LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQ 310
Score = 63.5 bits (153), Expect = 6e-10
Identities = 46/143 (32%), Positives = 67/143 (46%), Gaps = 10/143 (6%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG +Q G SP +P+GY + +C W I +I L+F + L +D +
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----CG- 436
V DG ++ L+ R G +LP IVST S L + F + +GF A+YE + CG
Sbjct: 88 VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147
Query: 437 -GDVKKDYGHIQSPNYPDDYRPS 458
G++ K H N D R S
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYS 170
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 4/113 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
C G SP YP Y +++C+W+I VT G I + S ++ +D +E
Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLE 1858
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
+ DG AP G F G+ +P + ST ++L++ F+S + GF Y+ +
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTV 1911
Score = 59.3 bits (142), Expect = 1e-08
Identities = 53/169 (31%), Positives = 76/169 (44%), Gaps = 16/169 (9%)
Query: 269 IMHYARNTFSRGIFLDTIV-----PKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPA-C 322
I +Y G F DT+V P Y ++G T LS + L C A C
Sbjct: 1223 IPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNT----LTCLSGDRRVWDKPLPSCIAEC 1278
Query: 323 GETLQDST-GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
G + +T G SP YP Y ++HC W I PG+ I L+F D + +D ++
Sbjct: 1279 GGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMA----HDILK 1334
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
V DG L + GS LPE I ST + L ++F S ++ K F++
Sbjct: 1335 VWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQF-DSDFFISKSGFSI 1382
Score = 57.4 bits (137), Expect = 5e-08
Identities = 35/114 (30%), Positives = 56/114 (49%), Gaps = 7/114 (6%)
Query: 318 KCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
+C A CG + G SP +P+ Y C+W I+V PG + +NFT L
Sbjct: 2142 RCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN--- 2198
Query: 377 YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
DY+ V DG + +P G F G+ E S+ +++ ++F S++ GFF +
Sbjct: 2199 -DYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFH--SDFSNGGFFVL 2249
Score = 53.1 bits (126), Expect = 9e-07
Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 7/131 (5%)
Query: 303 TRLSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII 361
T L G + L +C A CG +++ + G SP +P+ Y + C+++I G+ I
Sbjct: 1085 TCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIH 1144
Query: 362 LNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIV-STDSRLWVEFRSSS 420
L S L+ D ++V DG + G F ++L I+ ST + LW+EF ++
Sbjct: 1145 LRTRSFQLFEG-----DTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNG 1199
Query: 421 NWVGKGFFAVY 431
+ +GF Y
Sbjct: 1200 SDTDQGFQLTY 1210
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 6/114 (5%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG S G SP YP+ Y+A C++ I+V P E ++ F +++ L D E
Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITV-PKEFVV--FGQFAYFQTAL--NDLAE 1680
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
+ DG +A L GS E + ++T +++ + F + S +GF VY+A+
Sbjct: 1681 LFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAV 1734
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 6/91 (6%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L C A CG +Q +G SP +P+ Y ++C W I V+ G+ + + F + L S
Sbjct: 924 LPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS-- 981
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI 405
+DY+ + + P+ R GS LP I
Sbjct: 982 --HDYLLITEDGSFSEPV-ARLTGSVLPHTI 1009
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
+CPA E S+G SP YP Y C W I V P I + +D ++S +
Sbjct: 2319 QCPA-NEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITI---FVDTFQSEK-QF 2373
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEP-IVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
D +EV DG ++PL G+ + S ++L++ + + KGF Y A
Sbjct: 2374 DALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA 2430
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 154 bits (390), Expect = 2e-37
Identities = 96/288 (33%), Positives = 152/288 (52%), Gaps = 32/288 (11%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG++ + G I SP +P+ Y S C+W+I V EG + + SF E++ +D LE
Sbjct: 1796 CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WDSLE 1851
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF----FKEVDE 550
V DG + T++G + G P + STS++L+L F SD S++ AGF + + E
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPE 1911
Query: 551 CSRPNRG--GCEQRCLNTLGSYKCSCDPGYELA--------PDKRR--------CEAACG 592
+ P+ G E+ +N + S++C +PGY L P R C A CG
Sbjct: 1912 PAVPSNGVKTGERYLVNDVVSFQC--EPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCG 1969
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G + ++ G I SPG+P YP N +C W++ P + +QF F TE N +D++E+R
Sbjct: 1970 GTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIEIR 2025
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
+G S++ G+F GSE P + S + V F SD++ ++ GFK +
Sbjct: 2026 NGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEY 2073
Score = 148 bits (373), Expect = 2e-35
Identities = 100/303 (33%), Positives = 139/303 (45%), Gaps = 34/303 (11%)
Query: 433 AICGGDVKKDY-GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
A CGG V+ + G + SP YP Y + CIW I+ G +GL F F+ E +D
Sbjct: 1269 AECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE----VHD 1324
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
L + DG ES L+ G P D+ ST + + L+F +D +K GFA+ F V
Sbjct: 1325 VLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQF--SVSTA 1382
Query: 552 SRPNRGGCEQRCLNTLGSYKCS------CDPGYELA-----------------PDKRRCE 588
+ N G Q + S++ CDPGY L P C
Sbjct: 1383 TSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCI 1442
Query: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
A CGG LT +G I SP +P+ YPP K C W++ Y I+L F+ F E YDF
Sbjct: 1443 APCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPG----YDF 1498
Query: 649 VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPAL 708
+ + G + S L G F GS+ P I S N++ + F+SD +VS GF + R +
Sbjct: 1499 LHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESC 1558
Query: 709 QPP 711
P
Sbjct: 1559 FDP 1561
Score = 135 bits (341), Expect = 1e-31
Identities = 93/307 (30%), Positives = 143/307 (46%), Gaps = 34/307 (11%)
Query: 417 RSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLT 476
+ ++ W K V+ C + G + SPNYP+DY C+W I + L
Sbjct: 562 QKNNQWSAKKPGCVFS--CFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLA 619
Query: 477 FQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSIN 536
F ++E +D+L ++DG + + ++G + G + P I S+ L+F +D S
Sbjct: 620 FNDIDVEPQ----FDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTG 675
Query: 537 KAGFAVNF--FKEVDECSRPN------RGG------------CEQRCLNTLGSYKCSC-- 574
K GF + F F+ +EC P R G C++ L T GS +C
Sbjct: 676 KRGFNITFTTFRH-NECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVL 734
Query: 575 -DPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQF 633
+ RCEA CGG LT +G+I SPGWP Y +C W + A Y I + F
Sbjct: 735 KEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITF 794
Query: 634 DFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSK 693
D F+TE N YD +EVR G T + L G + G++ P+ + S N + + F +D + S
Sbjct: 795 DRFKTEVN----YDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSD 850
Query: 694 KGFKAHF 700
GF+ +
Sbjct: 851 IGFQLRY 857
Score = 125 bits (315), Expect = 1e-28
Identities = 84/288 (29%), Positives = 141/288 (48%), Gaps = 29/288 (10%)
Query: 434 ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDY 492
+C ++ G I SPN+P Y + C+W I ++ + L F+ F++ER YD
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLER----GYDT 459
Query: 493 LEVRDG--HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVD 549
L V DG + T++ G PD I ST+ ++WL F +DGS + GF ++ + E
Sbjct: 460 LTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQG 519
Query: 550 ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
C P G E + + K C P +EL K C +C
Sbjct: 520 SCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCF 579
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
T +G + SP +P++Y + +C+W ++A + RI L F+ + E ++DF+ ++
Sbjct: 580 FNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP----QFDFLVIK 635
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
G TA++ + G F G++ P ITS + R+EF++D++ K+GF F
Sbjct: 636 DGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF 683
Score = 125 bits (314), Expect = 1e-28
Identities = 92/292 (31%), Positives = 137/292 (46%), Gaps = 32/292 (10%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
EA CGG + G I SP +P Y+ + C W I+ G+ + +TF F+ E + YD
Sbjct: 749 EAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVN----YD 804
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EV 548
LEVRDG + S+ LIG Y G + P + STS+ L+L F +D S + GF + + +
Sbjct: 805 TLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQS 864
Query: 549 DECSRPNRGGCEQRCLN-----TLGSYKCS------------CDPGYELAPDKRRCEAAC 591
D C P QR N L ++ C C+P ++ + CEA C
Sbjct: 865 DHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALC 924
Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
GGF+ +G+I SPG+P YP N NC W + + F F E +D++ +
Sbjct: 925 GGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESG----HDYLLI 980
Query: 652 RSGLTADSKLHGKFCGSEKPEVITS-QYNNM--RVEFKSDNTVSKKGFKAHF 700
+ L + GS P I++ Y N +V F SD ++S +GF F
Sbjct: 981 TENGSFTQPLR-QLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITF 1031
Score = 122 bits (306), Expect = 1e-27
Identities = 87/291 (29%), Positives = 133/291 (45%), Gaps = 32/291 (10%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CG V G + SPN+P +Y + CI+ IQ G + L ++FE+ D
Sbjct: 1096 AECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGD-----V 1150
Query: 493 LEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
L+V DG++ S+ L+G + E + STSS LWL F++D GF ++F E+ +
Sbjct: 1151 LKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIK 1210
Query: 551 CSRPNRGGCEQRCLN----TLGSYKCSCDPGYELAPDKR----------------RCEAA 590
C P + + S SCDPGY L + C A
Sbjct: 1211 CEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAE 1270
Query: 591 CGGFLT-KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
CGG + +++G + SPG+P Y N NCIW + A I L F F+TE +D +
Sbjct: 1271 CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE----VHDVL 1326
Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
+ G L + G P+ + S +N++ ++F +D SK+GF F
Sbjct: 1327 RIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQF 1377
Score = 117 bits (293), Expect = 4e-26
Identities = 85/318 (26%), Positives = 133/318 (41%), Gaps = 70/318 (22%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG V++ G I SP +P +Y + C W+I + GF + F +F E + +DY
Sbjct: 1966 AQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDY 2021
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK------ 546
+E+R+G E+S ++GR+ G E P + STS + F SD S N+ GF + +
Sbjct: 2022 IEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQ 2081
Query: 547 --------EVDECSRPNR-------------GGCE----QRC---------------LNT 566
++ E R N GCE Q C N
Sbjct: 2082 ISSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNV 2141
Query: 567 LGSYKCSCDPGYELAPDK----------------RRCEAACGGFLTKLNGSITSPGWPKE 610
S C PGY+L +CE CGG +T NG++ SPG+P
Sbjct: 2142 GQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSP 2201
Query: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Y +++C+W + P + + L +TE + DF+ + G + G F S
Sbjct: 2202 YSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFITIWDGPQQTAPRLGVFTRSMA 2257
Query: 671 PEVITSQYNNMRVEFKSD 688
+ + S N + ++F D
Sbjct: 2258 KKTVQSSSNQVLLKFHRD 2275
Score = 112 bits (281), Expect = 9e-25
Identities = 86/298 (28%), Positives = 130/298 (43%), Gaps = 37/298 (12%)
Query: 430 VYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCA 489
V A CGG G + SPNYP +Y ++C++ + V + + V F F +
Sbjct: 1614 VCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFH-----TAL 1668
Query: 490 YDYLEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEV 548
D +EV DGHS+ S L+ G + + +TS+++ +KF + G GF ++ V
Sbjct: 1669 NDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHF-VYQAV 1727
Query: 549 DECSRPNRGGC-EQRCLNTLGS-------YKCSCDPGYELAPDKR--------------- 585
S E R LGS + C+ GY L
Sbjct: 1728 PRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNV 1787
Query: 586 ---RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGND 642
C CGG LT+ G+I SPG+P+ Y + NC+W++V P I +Q F TE N
Sbjct: 1788 SAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN- 1846
Query: 643 VCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
+D +EV G + G F G+ P ++ S N + + F SD +VS GF +
Sbjct: 1847 ---WDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEY 1901
Score = 111 bits (278), Expect = 2e-24
Identities = 90/292 (30%), Positives = 130/292 (44%), Gaps = 40/292 (13%)
Query: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS 503
G ++SP +P Y C W I E + L FQSF +E +D L V DG +
Sbjct: 35 GTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEED----FDVLSVFDGPPQPE 90
Query: 504 TLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEV---DECSRPNR--GG 558
L R G++ P I S ++ L L+ +SD +++ GF + EV C P R G
Sbjct: 91 NLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATY--EVLPSHTCGNPGRLPNG 148
Query: 559 CEQRCLNTLGS---YKCS------------CDPGYELAPD------KRRCEAACGGFLTK 597
+Q LG Y C+ C G E + R + ACGG L
Sbjct: 149 IQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRG 208
Query: 598 LNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTA 657
+G I+SP +P EY N +C W ++A I+L F F+ E YDF+EV T
Sbjct: 209 QSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLEVTG--TE 262
Query: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQ 709
S L F G+ P + S N +R+ F SD ++GF A + +K+ L+
Sbjct: 263 GSSLW--FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELK 312
Score = 108 bits (270), Expect = 2e-23
Identities = 123/485 (25%), Positives = 190/485 (39%), Gaps = 100/485 (20%)
Query: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
L +G + + +C A CG L +G SP +P Y + C W I PG I +
Sbjct: 734 LKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKIT 793
Query: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
F D +++ + YD +EVRDG APL G + G+++P+ ++ST + L++ F + +
Sbjct: 794 F---DRFKTEVN-YDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHS 849
Query: 424 GKGFFAVYEAIC------------------GGD--------VKKDYGHIQSPNYPDDYRP 457
GF YE I G D D G+ S P + P
Sbjct: 850 DIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEP 909
Query: 458 S-----------KVCIWRIQVSEGFHVGLTFQSFEIER---------------------- 484
+ +C IQ S G + F F
Sbjct: 910 NFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTF 969
Query: 485 HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFA 541
H +DYL + + S + L + G P I + + ++F+SD S++ GF
Sbjct: 970 HLESGHDYLLITENGSFTQPL-RQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFN 1028
Query: 542 VNFFK-EVDECSRPN------RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------- 585
+ F + +++ C P R G + +TL SC PGY L R
Sbjct: 1029 ITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTL---TFSCFPGYRLEGTARITCLGGRRR 1085
Query: 586 -------RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFET 638
RC A CG +T G++ SP +P Y N CI+ + I L+ FE
Sbjct: 1086 LWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFEL 1145
Query: 639 EGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFK 697
DV K V G ++L G F SE V + S +++ ++F +D + KGF+
Sbjct: 1146 SEGDVLK-----VYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFE 1200
Query: 698 AHFFS 702
HF S
Sbjct: 1201 LHFSS 1205
Score = 94.0 bits (232), Expect = 4e-19
Identities = 79/310 (25%), Positives = 129/310 (41%), Gaps = 37/310 (11%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
E CGG++ G + SP +P Y S+ C+W I V G V L + E + D
Sbjct: 2179 EVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEP----SGD 2234
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
++ + DG +++ +G + ++S+S+++ LKF D + FA+ F + +
Sbjct: 2235 FITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGI-FAIAFSAYPLTK 2293
Query: 551 CSRPN-----RGGCEQRCLNTLGSYKCSCDPGYELAPDK----------------RRCEA 589
C P E N + C PG+ L ++ CE
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEV 2353
Query: 590 AC--GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
C LT G I S +P YP + C W + Y ISL ++F +E +YD
Sbjct: 2354 HCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK----QYD 2409
Query: 648 FVEVRSGLTADSKLHGKFCGS-EKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706
E+ G + S L G+ P ++TS N++ + + SD+ ++KGFK + P
Sbjct: 2410 EFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRY---SAP 2466
Query: 707 ALQPPRGRPH 716
PR H
Sbjct: 2467 YCSLPRAPLH 2476
Score = 92.8 bits (229), Expect = 1e-18
Identities = 125/503 (24%), Positives = 189/503 (37%), Gaps = 139/503 (27%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDL------------ 369
C L G SP +P GY + +C W I+ +I L F S L
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG 85
Query: 370 ------YRSRLCWY-------------------DYVEVRDGFWRKAP-LRGRFCGS--KL 401
R+RL + DY GF L CG+ +L
Sbjct: 86 PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRL 145
Query: 402 PEPIVSTDS-RLWVEFRSSSNWVGKGFFAVYEAI-------------------------C 435
P I + L + R S N GFF A+ C
Sbjct: 146 PNGIQQGSTFNLGDKVRYSCNL---GFFLEGHAVLTCHAGSENSATWDFPLPSCRADDAC 202
Query: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
GG ++ G I SP++P +Y + C W I G + L F F++E YD+LEV
Sbjct: 203 GGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLED----GYDFLEV 258
Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSR 553
+E S+L + G P + S+ + L L F SDG+ + GF+ + K+++ SR
Sbjct: 259 TG--TEGSSL--WFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSR 314
Query: 554 -----PNRGGCEQRCLNT----------------------LG-------SYKCSCDPGYE 579
P++ ++ + T LG S + +C+ GY+
Sbjct: 315 GVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYD 374
Query: 580 LAPDKR------------------RCEA-ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQ 620
L KR C A C L +G ITSP +P +Y N +C+W
Sbjct: 375 LQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWI 434
Query: 621 LVAPTQYR-ISLQFDFFETEGNDVCKYDFVEV-RSGLTADSK-LHGKFCGSEKPEVITSQ 677
+ A + I L F+ F+ E YD + V G D K + G+ P++I S
Sbjct: 435 ITALNPSKVIKLAFEEFDLERG----YDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVST 490
Query: 678 YNNMRVEFKSDNTVSKKGFKAHF 700
+ M + F++D + S GFKA +
Sbjct: 491 NHQMWLLFQTDGSGSSLGFKASY 513
Score = 70.1 bits (170), Expect = 7e-12
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 7/157 (4%)
Query: 272 YARNTFSRGIFLDTIVPKYEVNGVKPPIGQRT-RLSKGDIAQARKLYKCPACGETLQDST 330
Y R SR DT+ K+E +GQ+ K + A+K +C +
Sbjct: 529 YGRREGSRFHHGDTL--KFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPS 586
Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
G SP YP Y H+HCVW I P +I L F +D+ +D++ ++DG +A
Sbjct: 587 GVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQ----FDFLVIKDGATAEA 642
Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGF 427
P+ G F G++LP I S+ +EF++ + +GF
Sbjct: 643 PVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGF 679
Score = 66.6 bits (161), Expect = 8e-11
Identities = 34/111 (30%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG T+++ G SP +P Y ++M C W+I++ G + F + + +DY+E
Sbjct: 1968 CGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIE 2023
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
+R+G + + + GRF GS+LP ++ST V F S + GF Y+
Sbjct: 2024 IRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074
Score = 65.1 bits (157), Expect = 2e-10
Identities = 38/110 (34%), Positives = 55/110 (50%), Gaps = 4/110 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L +G SP YP Y C W+++V+P I L F +L YD++
Sbjct: 1445 CGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPG----YDFLH 1500
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
+ DG +PL G F GS+LP I S+ + L++ FRS ++ GF Y
Sbjct: 1501 IYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY 1550
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/116 (32%), Positives = 54/116 (46%), Gaps = 16/116 (13%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG TL+ +G SSP +P+ Y + C W I G+ I L F L YD++
Sbjct: 201 ACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFL 256
Query: 381 EVR----DGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
EV W F G+ LP P++S+ + L + F S N +GF A Y+
Sbjct: 257 EVTGTEGSSLW--------FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQ 304
Score = 59.3 bits (142), Expect = 1e-08
Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 314 RKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRS 372
R + + C L+ +G +SP +P Y + HCVW I ++ P + I L F DL R
Sbjct: 397 RPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERG 456
Query: 373 RLCWYDYVEVRDG--FWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
YD + V DG + + G+ +P+ IVST+ ++W+ F++ + GF A
Sbjct: 457 ----YDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKAS 512
Query: 431 YEAI----CGGDVKKDYGHIQSPNY 451
YE I CG YG + +
Sbjct: 513 YEEIEQGSCGDPGIPAYGRREGSRF 537
Score = 57.0 bits (136), Expect = 6e-08
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 4/113 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L + G SP +P Y ++CVW+I V G I + S ++ +D +E
Sbjct: 1796 CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WDSLE 1851
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
V DG + G F G+ +P + ST ++L++ F S + GF Y+ +
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904
Score = 53.1 bits (126), Expect = 9e-07
Identities = 38/124 (30%), Positives = 61/124 (49%), Gaps = 10/124 (8%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L +C A CG ++ + G SP +P Y+ + C++ I PG+ I L + +L
Sbjct: 1091 LPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-- 1148
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSK-LPEPIVSTDSRLWVEFRSSSNWVGKGF---FAV 430
D ++V DG A L G F S+ + + ST S LW++F + + KGF F+
Sbjct: 1149 ---DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS 1205
Query: 431 YEAI 434
+E I
Sbjct: 1206 FELI 1209
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L KC CG + S G SP +P+ YS+ CVW I+V G + LN + L S
Sbjct: 2175 LPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG- 2233
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
D++ + DG + AP G F S + + S+ +++ ++F + G FA+
Sbjct: 2234 ---DFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDA--ATGGIFAI 2284
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
CP E L DSTG S YP Y C W + V P I L +++ + S YD
Sbjct: 2355 CPT-NELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISL---TVEYFLSEK-QYD 2409
Query: 379 YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
E+ DG ++PL G+ P + S+ + +++ + S + KGF Y A
Sbjct: 2410 EFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA 2465
Score = 44.7 bits (104), Expect = 3e-04
Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 314 RKLYKCPA-CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
R L C A CG T++ + +G SP YP Y +++C+W I G I L+F D
Sbjct: 1262 RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE 1321
Query: 372 SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
+D + + DG L G LP+ + ST + + ++F S+ + K FA+
Sbjct: 1322 V----HDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQF-STDFFTSKQGFAIQ 1376
Query: 432 EAICGGDVKKDYGHIQSPNYPDD 454
++ D G Q+ + D
Sbjct: 1377 FSVSTATSCNDPGIPQNGSRSGD 1399
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/114 (27%), Positives = 56/114 (49%), Gaps = 6/114 (5%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG S G SP YP Y++ C++ ++V P + ++ F + + L D VE
Sbjct: 1619 CGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTV-PKDYVV--FGQFAFFHTAL--NDVVE 1673
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
V DG + + L GS E + ++T +++ ++F + +GF VY+A+
Sbjct: 1674 VHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAV 1727
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 154 bits (388), Expect = 4e-37
Identities = 92/281 (32%), Positives = 138/281 (49%), Gaps = 18/281 (6%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
++ CGG + G SPNYPD Y P+ C+W IQV+ + L ++ IE SC +D
Sbjct: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
LE+ E + R CG P + + +S L + FVSD S+ GF + +
Sbjct: 201 RLELSP---EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
Query: 552 SRPNRGGC---EQRCLNTLGSYKCSCDPGYELAPD---KRRCEA---ACGGFLTKLNGSI 602
P RG C E RC + S G+ D + C A CGG LT L G+
Sbjct: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
Query: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661
++P + ++YP C W + P + I LQF F E D CK+D+VEV + + L
Sbjct: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
Query: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
G+FCG+E P + S ++ + V F++D+ +S GF A + +
Sbjct: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
Score = 117 bits (293), Expect = 4e-26
Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L G FSSP YP+ Y + HCVW I V I L +L + C +D +E
Sbjct: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434
+ + PL R CG ++P P ++T+ S L V F S S+ G GF A Y+A+
Sbjct: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
Query: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453
CGG++ G +P+Y
Sbjct: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
Query: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512
Y +C W I V G + L F +F +E D C +DY+EV + S + +L+GR+CG
Sbjct: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
Query: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560
E P + S+ L + F +D I+ GF+ + F + P+ C+
Sbjct: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
Score = 72.0 bits (175), Expect = 2e-12
Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)
Query: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
K CG L G FS+P Y Y + C W ISV G I L F + L C +
Sbjct: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
Query: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
DYVEV + A L GRFCG++ P +VS+ L V FR+ GF A Y A
Sbjct: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
sapiens]
Length = 380
Score = 153 bits (386), Expect = 6e-37
Identities = 96/300 (32%), Positives = 146/300 (48%), Gaps = 30/300 (10%)
Query: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502
+G IQSP YPD Y W I V +GF + L F F +E C YDY++V
Sbjct: 28 FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
Query: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551
++ +CG E D + S S + + F SD S + GF ++ +VDEC
Sbjct: 84 DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
Query: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608
C+ C N +G Y CSC GY L D R C C T+ G ITSP +P
Sbjct: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
Query: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665
YP + C++ + + ++LQF D F+ E + C YD+++++ G K+ G F
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSEKRPALQPP---RGRPHQLKF 720
CG + PE I++Q +++ + F SDN+ +G++ + + P LQPP + P Q K+
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKY 319
Score = 95.9 bits (237), Expect = 1e-19
Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)
Query: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
L K A L + G SP YP+ Y + W I+V G +I L F +L S LC
Sbjct: 14 LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425
YDYV+V + + FCG + E ++S S + + FRS S+
Sbjct: 74 EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
Query: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443
GF A Y A+ + K+ D+
Sbjct: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
Query: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495
G I SP++P+ Y S C++ I++ EGF V L F+ F+IE H C YDY+++
Sbjct: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553
+ G ++G +CG + P+ I + S + + F SD S G+ +++ +EC
Sbjct: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
Query: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583
P G E Q SCD GY++ D
Sbjct: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
Score = 67.0 bits (162), Expect = 6e-11
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 14/118 (11%)
Query: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
L + G I SPG+P YP + W + P +RI L F F E + +C+YD+V+V +
Sbjct: 24 LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
Query: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFS 702
+ ++ FCG E EV+ S + M + F+SD N GF AH+ +
Sbjct: 83 ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMA 137
>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
precursor [Homo sapiens]
Length = 728
Score = 153 bits (386), Expect = 6e-37
Identities = 96/300 (32%), Positives = 146/300 (48%), Gaps = 30/300 (10%)
Query: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502
+G IQSP YPD Y W I V +GF + L F F +E C YDY++V
Sbjct: 28 FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
Query: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551
++ +CG E D + S S + + F SD S + GF ++ +VDEC
Sbjct: 84 DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
Query: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608
C+ C N +G Y CSC GY L D R C C T+ G ITSP +P
Sbjct: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
Query: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665
YP + C++ + + ++LQF D F+ E + C YD+++++ G K+ G F
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSEKRPALQPP---RGRPHQLKF 720
CG + PE I++Q +++ + F SDN+ +G++ + + P LQPP + P Q K+
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKY 319
Score = 95.9 bits (237), Expect = 1e-19
Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)
Query: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
L K A L + G SP YP+ Y + W I+V G +I L F +L S LC
Sbjct: 14 LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425
YDYV+V + + FCG + E ++S S + + FRS S+
Sbjct: 74 EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
Query: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443
GF A Y A+ + K+ D+
Sbjct: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
Query: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495
G I SP++P+ Y S C++ I++ EGF V L F+ F+IE H C YDY+++
Sbjct: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553
+ G ++G +CG + P+ I + S + + F SD S G+ +++ +EC
Sbjct: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
Query: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583
P G E Q SCD GY++ D
Sbjct: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
Score = 67.0 bits (162), Expect = 6e-11
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 14/118 (11%)
Query: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
L + G I SPG+P YP + W + P +RI L F F E + +C+YD+V+V +
Sbjct: 24 LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
Query: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFS 702
+ ++ FCG E EV+ S + M + F+SD N GF AH+ +
Sbjct: 83 ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMA 137
>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
precursor [Homo sapiens]
Length = 699
Score = 153 bits (386), Expect = 6e-37
Identities = 96/300 (32%), Positives = 146/300 (48%), Gaps = 30/300 (10%)
Query: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502
+G IQSP YPD Y W I V +GF + L F F +E C YDY++V
Sbjct: 28 FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
Query: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551
++ +CG E D + S S + + F SD S + GF ++ +VDEC
Sbjct: 84 DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
Query: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608
C+ C N +G Y CSC GY L D R C C T+ G ITSP +P
Sbjct: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
Query: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665
YP + C++ + + ++LQF D F+ E + C YD+++++ G K+ G F
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSEKRPALQPP---RGRPHQLKF 720
CG + PE I++Q +++ + F SDN+ +G++ + + P LQPP + P Q K+
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKY 319
Score = 95.9 bits (237), Expect = 1e-19
Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)
Query: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
L K A L + G SP YP+ Y + W I+V G +I L F +L S LC
Sbjct: 14 LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425
YDYV+V + + FCG + E ++S S + + FRS S+
Sbjct: 74 EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
Query: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443
GF A Y A+ + K+ D+
Sbjct: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
Query: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495
G I SP++P+ Y S C++ I++ EGF V L F+ F+IE H C YDY+++
Sbjct: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553
+ G ++G +CG + P+ I + S + + F SD S G+ +++ +EC
Sbjct: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
Query: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583
P G E Q SCD GY++ D
Sbjct: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
Score = 67.0 bits (162), Expect = 6e-11
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 14/118 (11%)
Query: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
L + G I SPG+P YP + W + P +RI L F F E + +C+YD+V+V +
Sbjct: 24 LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
Query: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFS 702
+ ++ FCG E EV+ S + M + F+SD N GF AH+ +
Sbjct: 83 ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMA 137
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 152 bits (385), Expect = 8e-37
Identities = 82/268 (30%), Positives = 134/268 (50%), Gaps = 37/268 (13%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG + + G I S +P Y P+ C W+I V EG V L F+ ++E + C YD+++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
V +GH+ IGR+CG +P + S+ +++ ++ +SD + GF F + P
Sbjct: 93 VYNGHANGQR-IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAEP 146
Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
N G + CGG L + +GS +P WP ++YP
Sbjct: 147 NERG-----------------------------DQYCGGLLDRPSGSFKTPNWPDRDYPA 177
Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKLHGKFCGSEKPE 672
C+W +VAP I L+F+ F+ E ++ C+YD+V V G D++ GK+CG P
Sbjct: 178 GVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
Query: 673 VITSQYNNMRVEFKSDNTVSKKGFKAHF 700
I S+ N + ++F SD +++ GF H+
Sbjct: 238 PIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 148 bits (373), Expect = 2e-35
Identities = 89/284 (31%), Positives = 137/284 (48%), Gaps = 31/284 (10%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L +G S +P Y + C W+I+V G+ ++LNF +DL LC YD+V+
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
V +G + GRFCG+ P +VS+ +++ V+ S +N G GF A++ A
Sbjct: 93 VYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
Query: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
CGG + + G ++PN+PD DY C+W I + + L F+ F++ER + C YD
Sbjct: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
Query: 492 YLEV-RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE--- 547
Y+ V G + IG+YCG P I S + L ++F+SD S+ GF ++
Sbjct: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
Query: 548 --------------VDECSRPNRGGCEQRC--LNTLGSYKCSCD 575
V +P C+Q+C TL CS D
Sbjct: 272 LPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSD 315
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 150 bits (379), Expect = 4e-36
Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
CGG + KD G+I SP YP DY + C W + E + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
++E+RDG SES+ L+G++CG P I S+ S L++KF SD + AGF++ + FK
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
GS CS + T NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP N +C + ++A + I LQF F+ E G CKYD++++ G+ L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
K+CG++ P + S + + F +D V+K GF A ++
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 138 bits (347), Expect = 2e-32
Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)
Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
P CG L G +SP YP Y +H +C W + + P +KI+LNF C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
D++E+RDG A L G+ CG+ P I+S+ S L+++F S G GF YE G
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
D K++ G I+SP +P+ Y + C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
C YD+L++ DG LIG+YCG + P +++S++ L L F +D ++ K GF+ +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 545 F 545
+
Sbjct: 265 Y 265
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 150 bits (379), Expect = 4e-36
Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
CGG + KD G+I SP YP DY + C W + E + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
++E+RDG SES+ L+G++CG P I S+ S L++KF SD + AGF++ + FK
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
GS CS + T NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP N +C + ++A + I LQF F+ E G CKYD++++ G+ L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
K+CG++ P + S + + F +D V+K GF A ++
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 138 bits (347), Expect = 2e-32
Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)
Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
P CG L G +SP YP Y +H +C W + + P +KI+LNF C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
D++E+RDG A L G+ CG+ P I+S+ S L+++F S G GF YE G
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
D K++ G I+SP +P+ Y + C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
C YD+L++ DG LIG+YCG + P +++S++ L L F +D ++ K GF+ +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 545 F 545
+
Sbjct: 265 Y 265
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 150 bits (379), Expect = 4e-36
Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
CGG + KD G+I SP YP DY + C W + E + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
++E+RDG SES+ L+G++CG P I S+ S L++KF SD + AGF++ + FK
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
GS CS + T NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP N +C + ++A + I LQF F+ E G CKYD++++ G+ L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
K+CG++ P + S + + F +D V+K GF A ++
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 138 bits (347), Expect = 2e-32
Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)
Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
P CG L G +SP YP Y +H +C W + + P +KI+LNF C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
D++E+RDG A L G+ CG+ P I+S+ S L+++F S G GF YE G
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
D K++ G I+SP +P+ Y + C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
C YD+L++ DG LIG+YCG + P +++S++ L L F +D ++ K GF+ +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 545 F 545
+
Sbjct: 265 Y 265
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 150 bits (379), Expect = 4e-36
Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
CGG + KD G+I SP YP DY + C W + E + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
++E+RDG SES+ L+G++CG P I S+ S L++KF SD + AGF++ + FK
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
GS CS + T NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP N +C + ++A + I LQF F+ E G CKYD++++ G+ L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
K+CG++ P + S + + F +D V+K GF A ++
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 138 bits (347), Expect = 2e-32
Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)
Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
P CG L G +SP YP Y +H +C W + + P +KI+LNF C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
D++E+RDG A L G+ CG+ P I+S+ S L+++F S G GF YE G
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
D K++ G I+SP +P+ Y + C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
C YD+L++ DG LIG+YCG + P +++S++ L L F +D ++ K GF+ +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 545 F 545
+
Sbjct: 265 Y 265
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 150 bits (379), Expect = 4e-36
Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
CGG + KD G+I SP YP DY + C W + E + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
++E+RDG SES+ L+G++CG P I S+ S L++KF SD + AGF++ + FK
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
GS CS + T NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP N +C + ++A + I LQF F+ E G CKYD++++ G+ L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
K+CG++ P + S + + F +D V+K GF A ++
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 138 bits (347), Expect = 2e-32
Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)
Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
P CG L G +SP YP Y +H +C W + + P +KI+LNF C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
D++E+RDG A L G+ CG+ P I+S+ S L+++F S G GF YE G
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
D K++ G I+SP +P+ Y + C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
C YD+L++ DG LIG+YCG + P +++S++ L L F +D ++ K GF+ +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 545 F 545
+
Sbjct: 265 Y 265
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 150 bits (379), Expect = 4e-36
Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
CGG + KD G+I SP YP DY + C W + E + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
++E+RDG SES+ L+G++CG P I S+ S L++KF SD + AGF++ + FK
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
GS CS + T NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP N +C + ++A + I LQF F+ E G CKYD++++ G+ L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
K+CG++ P + S + + F +D V+K GF A ++
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 138 bits (347), Expect = 2e-32
Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)
Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
P CG L G +SP YP Y +H +C W + + P +KI+LNF C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
D++E+RDG A L G+ CG+ P I+S+ S L+++F S G GF YE G
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
D K++ G I+SP +P+ Y + C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
C YD+L++ DG LIG+YCG + P +++S++ L L F +D ++ K GF+ +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 545 F 545
+
Sbjct: 265 Y 265
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 146 bits (369), Expect = 6e-35
Identities = 107/304 (35%), Positives = 146/304 (48%), Gaps = 29/304 (9%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG + G I SP +P +Y S C W I + GF V L F +F E +DY
Sbjct: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
LEVR G SE+ST+IGR G + P + ST+ L F SD S NK GF + + ++ C
Sbjct: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184
Query: 552 S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592
RP R G T+G + C PGY L + RCEA CG
Sbjct: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G +T +NG+I SPG+P EYP ++C W + P I + F +TE YDF+ V
Sbjct: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712
G +S G+F G+ E + S N + ++F SD T S F + + + QPP
Sbjct: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRVCQPPP 2359
Query: 713 GRPH 716
P+
Sbjct: 2360 PVPN 2363
Score = 144 bits (364), Expect = 2e-34
Identities = 102/301 (33%), Positives = 142/301 (47%), Gaps = 30/301 (9%)
Query: 433 AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
A CGG K + G I SP YP Y + C+W I+V G V L F +F+ E ++D
Sbjct: 1372 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1427
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
L V DG E+ L+ G P+ I ST + + ++F +D I+K+GFA+ F V
Sbjct: 1428 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1487
Query: 552 SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590
R P G + CDPGYEL ++R C A
Sbjct: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1547
Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
CGG LT +G I SP +P YP +++C W + Y ISL F F E N YDF+
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603
Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQP 710
+ G ++S L G F S+ PE I S N M + F+SD +VS GF + ++ R +
Sbjct: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663
Query: 711 P 711
P
Sbjct: 1664 P 1664
Score = 136 bits (343), Expect = 6e-32
Identities = 93/291 (31%), Positives = 140/291 (48%), Gaps = 32/291 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
C + G + SP+YP+ Y + CIW I G + L+F F++E +D+L
Sbjct: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 736
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552
V+DG S S ++G + G E P + S S L L+F +D S++ GF + N F +EC
Sbjct: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 795
Query: 553 RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591
P R G CE+ + T G+ +C D + +C A C
Sbjct: 796 DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 855
Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
GG + +G I SPGWP Y + NC W + A + I + F+ F+TE N YD +EV
Sbjct: 856 GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 911
Query: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
G S L G + G++ P+ + S N + + F +DN+ S GFK H+ S
Sbjct: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYES 962
Score = 136 bits (343), Expect = 6e-32
Identities = 92/300 (30%), Positives = 146/300 (48%), Gaps = 32/300 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG + K G I SP YP+ Y + C+W+I V EG + + SF E + +D L+
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553
DG ++ +G Y G P + STS+ L+L F SD S++ AGF + + +D C
Sbjct: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 2014
Query: 554 PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592
P ++ + + S++C D GY L P +R C A CG
Sbjct: 2015 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2072
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G ++ +G I SPG+P YP + +C W + P + + LQF F TE +D++EVR
Sbjct: 2073 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2128
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712
SG + S + G+ G + P + S + + F SD + +K+GF + + + + PR
Sbjct: 2129 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPR 2188
Score = 136 bits (342), Expect = 8e-32
Identities = 98/300 (32%), Positives = 143/300 (47%), Gaps = 40/300 (13%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG++ G I SPN+P Y S+ C W I V+ + + L F SF IE + YD+
Sbjct: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
L + DG +S LIG + + P+ I+S+S+ + L F SDGS++ GF + + ++ E C
Sbjct: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661
Query: 552 SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587
P R G + + +T+ Y CD GY L P R C
Sbjct: 1662 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718
Query: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
A CG T G++ SP +PK Y NC++ + P ++ + QF FF+T +DV
Sbjct: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1774
Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706
VEV G T S L GS E + S N + + F S ++ KGF HF + P
Sbjct: 1775 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1831
Score = 124 bits (311), Expect = 3e-28
Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493
CG +++ G SPN+P Y + C+W I V+ + + F+ F++E YD L
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563
Query: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
+ DG + T++ G PD I S SS++WL +D S+ GF VN+ + E +
Sbjct: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623
Query: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593
C P G E + + C G+EL +K C C
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683
Query: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653
T G++ SP +P+ Y N NCIW +++ RI L F+ F+ E ++DF+ V+
Sbjct: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 739
Query: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
G + +S + G F G+E P +TS + +R+EF++D+++S +GF
Sbjct: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 782
Score = 115 bits (287), Expect = 2e-25
Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG +K G I+SP +P Y C W I E + + FQSF +E YDYL
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
+ DGH + R G+ P + ST S L+ SD +++ GF V +++E+ S
Sbjct: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139
Query: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589
N G + L + + SC GY L + R E
Sbjct: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199
Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
ACGG + +G I+SP +P EY N +C W +VA ISL F F+ E KYD++
Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255
Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
E+ L G P I S N +R+ F +D+ +GF A +
Sbjct: 256 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302
Score = 113 bits (283), Expect = 5e-25
Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG G I SP +P Y+ S C W I+ G + +TF+ F+ E + YD
Sbjct: 853 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 908
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549
LEV DG + S L+G Y G + P + S+S+ ++L F +D S + GF +++
Sbjct: 909 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 968
Query: 550 ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
C P G + + SCD GY L+ ++ C+A CG
Sbjct: 969 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 1028
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G + +G+I SPG+P+ YP + NC W + + F F E + +D++ +
Sbjct: 1029 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1084
Query: 653 SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700
+ L + GS+ P I + Y N R + F SD ++S +GF F
Sbjct: 1085 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1134
Score = 113 bits (282), Expect = 7e-25
Identities = 84/294 (28%), Positives = 128/294 (43%), Gaps = 35/294 (11%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CG G + SPNYP +Y C++ I V + F V F F+ HD
Sbjct: 1720 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1774
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
+EV DG ++ S+L+ G + + S+ +++ ++F S G I GF +
Sbjct: 1775 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834
Query: 552 SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586
S E R +G S C+PGY E P+
Sbjct: 1835 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894
Query: 587 CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
C CGG LTK G+I SPG+P+ Y N NC+W++ P I +Q F TE N +
Sbjct: 1895 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1950
Query: 647 DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
D ++ G ++ G + G+ P ++ S NN+ + F+SD +VS GF +
Sbjct: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 2004
Score = 105 bits (262), Expect = 1e-22
Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
+A+CGGDV+ G I SP YP+ Y S C W + V+ G V F +F +E H +D
Sbjct: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
YL + + S + L R G + P I + + R L+F+SD SI+ GF + F +
Sbjct: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138
Query: 548 VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
++ C P R G + SC GY L RC
Sbjct: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Query: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
A CG T G + SP +P Y N CI+ + I++ F DV K
Sbjct: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255
Query: 649 VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
+ G + L G F G S + ++S N + +EF SD + +GF+ + S
Sbjct: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308
Score = 100 bits (250), Expect = 4e-21
Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
EA+CGG++ G I SP YPD+Y + C W ++V G + + F + E YD
Sbjct: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549
++ V DG ++S IG++ G + + STS+++ +KF SD +GF V + ++
Sbjct: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2353
Query: 550 ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588
C P +CL +G+ +C G L D C+
Sbjct: 2354 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413
Query: 589 AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
C +L+ G I SPG+P YP + C W + Y I++ +FF+TE ++
Sbjct: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2469
Query: 647 DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
D ++V G S + G ITS + + +++ +D+ +KKGF+ + +
Sbjct: 2470 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526
Score = 90.9 bits (224), Expect = 4e-18
Identities = 114/438 (26%), Positives = 176/438 (40%), Gaps = 79/438 (18%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG T++ S+G SSP +PN Y + C W I PG+ I L FT + YDY+
Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE-------A 433
E+ P G +P PI+S + L + F + SN +GF A Y+
Sbjct: 256 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311
Query: 434 ICGGDVKK----DYGHIQSPNYPDDYRPSKVCIWRI-QVSEGFHVGLT-FQSFEIERHDS 487
G++++ G I + P D S V I ++SE V +T ++ ++ + S
Sbjct: 312 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 371
Query: 488 CAYDYLEVRDGHSESSTLIGRYC--------------GYEKPDDIKSTSSRLW------- 526
D L ++S+ R+ +K D KS +L+
Sbjct: 372 --KDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 429
Query: 527 -LKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGS-YKCSCDPGYELAPDK 584
+++G I A N + E R G + +LGS + SCD Y L K
Sbjct: 430 KFSILNEGGIKTAS---NLCPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAK 482
Query: 585 R-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-P 624
C+ CG L +G+ TSP +P +Y N C+W + A
Sbjct: 483 SITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVN 542
Query: 625 TQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMR 682
T I + F+ F+ E G D D EV T L G F P++I S + M
Sbjct: 543 TNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDLIVSMSSQMW 598
Query: 683 VEFKSDNTVSKKGFKAHF 700
+ ++D +V GFK ++
Sbjct: 599 LHLQTDESVGSVGFKVNY 616
Score = 73.9 bits (180), Expect = 5e-13
Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%)
Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
G SP+YP GY +++C+W I PG +I L+F DL +D++ V+DG ++
Sbjct: 690 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 745
Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450
P+ G F G+++P + S L +EF++ + G+GF Y +GH + P+
Sbjct: 746 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 796
Score = 70.5 bits (171), Expect = 5e-12
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 8/141 (5%)
Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
CGG L LNG+I SPG+P YP NC W ++A + RI + F F E +YD++
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 80
Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPAL-- 708
+ G + + G P +TS + + SD VS GFK ++ + +
Sbjct: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140
Query: 709 --QPPRGRPHQLKFRVQKRNR 727
PP+G + +F V + R
Sbjct: 141 PGVPPKGVLYGTRFDVGDKIR 161
Score = 64.3 bits (155), Expect = 4e-10
Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L +C A CG + G SP YP+ Y C W + V PG I +NFT L
Sbjct: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
YD++ V DG + +P G+F G+ E + ST +++ ++F S++ GFF +
Sbjct: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2345
Score = 62.8 bits (151), Expect = 1e-09
Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%)
Query: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312
EP+ + +G + S + ++ + Y + G K QR +
Sbjct: 451 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 498
Query: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371
R + K CG LQ +G F+SP +P Y ++ CVW I+ K+I +NF DL
Sbjct: 499 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 557
Query: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429
YD + + DG P + GS +P+ IVS S++W+ ++ + GF
Sbjct: 558 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 614
Query: 430 VYEAI----CGGDVKKDYG 444
Y+ I CG YG
Sbjct: 615 NYKEIEKESCGDPGTPLYG 633
Score = 62.4 bits (150), Expect = 1e-09
Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L S+G SP +P+ Y C W I+V I L F S + + YD++
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
+ DG +PL G F SKLPE I S+ + + + FRS + GF Y+A
Sbjct: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1655
Score = 61.2 bits (147), Expect = 3e-09
Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L G SP YP Y +++CVW+I+V G I + S + +D ++
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
DG AP G + G+ +P + ST + L++ F+S + GF Y AI
Sbjct: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007
Score = 60.8 bits (146), Expect = 4e-09
Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG + D +G SP +P Y + + C W I++ G + L F + S +DY+E
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
VR G + + GR G ++P + ST + F S + +GF VY+A
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178
Score = 59.7 bits (143), Expect = 9e-09
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%)
Query: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502
G I SP YPD Y ++C W I V +G+++ + + F+ E+ +D L+V DG + +S
Sbjct: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2482
Query: 503 STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559
LI Y +I S ++L++ +D NK GF + + CS P G
Sbjct: 2483 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2540
Query: 560 EQRCLNTLGS-YKCSCDPGYEL 580
+ L S + +CD G+ L
Sbjct: 2541 ISQTGGQLNSVVRWACDRGFRL 2562
Score = 59.3 bits (142), Expect = 1e-08
Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 8/145 (5%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
E CGG ++ G I SP++P++Y + C W I G + L F F++E YD
Sbjct: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
YLE+ SE T+ G P I S + L L FV+D + GF+ +
Sbjct: 254 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309
Query: 552 SRPNRGGCEQRCLNTLGSYKCSCDP 576
+ G E+ T G+ + P
Sbjct: 310 HTTSTGELEEHNRTTTGAIAVASTP 334
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Query: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
L G + + + KC A CG +G SP +P Y ++C W I PG I +
Sbjct: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896
Query: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
F + +++ L YD +EV DG +PL G + G+++P+ + S+ + +++ F + ++
Sbjct: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952
Query: 424 GKGFFAVYEAI 434
GF YE++
Sbjct: 953 NNGFKIHYESV 963
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG TL+ G SP +P GY +C W I +I + F S L YDY+
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
+ DG R R G LP P+ ST S + S GF YE +
Sbjct: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 133
Score = 57.0 bits (136), Expect = 6e-08
Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L +C A CG + ++ G SP YP Y + C++ I V G+ I ++ + L +
Sbjct: 1194 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1251
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
D +++ DG + L G F G+ + + ST ++LW+EF S + +GF VY +
Sbjct: 1252 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308
Query: 434 ICGGDVKKDYGHIQSPNYP 452
+ H + P P
Sbjct: 1309 F-------ELSHCEDPGIP 1320
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)
Query: 314 RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372
R L C A CG S G SP YP YS +CV+ I+V P E ++ F +++
Sbjct: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769
Query: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431
L +D VEV DG +++ L GS E + +S+ +++ + F S KGF VY
Sbjct: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827
Query: 432 EAI 434
+A+
Sbjct: 1828 QAV 1830
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%)
Query: 317 YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
Y P+C G +S+G SP YP Y ++ C+W I V PG + L F + D
Sbjct: 1365 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424
Query: 372 SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
S +D + V DG L GS +PE I ST + + ++F + ++ K FA+
Sbjct: 1425 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1478
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG ++ +G SP YP Y ++C W + VT G+ + NF + L +DY+
Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1082
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
+ + PL R GS LP I ++ L+ FR+ ++
Sbjct: 1083 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1120
Score = 38.9 bits (89), Expect = 0.017
Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%)
Query: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
CPA E DSTG SP YP+ Y C W ISV G I + + +D
Sbjct: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470
Query: 379 YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
++V DG ++P+ G I S +++++ + KGF Y A C
Sbjct: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530
Query: 437 GDVKKDYGHIQS 448
+G+I S
Sbjct: 2531 TPESPPHGYIIS 2542
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 146 bits (369), Expect = 6e-35
Identities = 107/304 (35%), Positives = 146/304 (48%), Gaps = 29/304 (9%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG + G I SP +P +Y S C W I + GF V L F +F E +DY
Sbjct: 2005 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2060
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
LEVR G SE+ST+IGR G + P + ST+ L F SD S NK GF + + ++ C
Sbjct: 2061 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2120
Query: 552 S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592
RP R G T+G + C PGY L + RCEA CG
Sbjct: 2121 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2180
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G +T +NG+I SPG+P EYP ++C W + P I + F +TE YDF+ V
Sbjct: 2181 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2236
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712
G +S G+F G+ E + S N + ++F SD T S F + + + QPP
Sbjct: 2237 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRVCQPPP 2295
Query: 713 GRPH 716
P+
Sbjct: 2296 PVPN 2299
Score = 144 bits (364), Expect = 2e-34
Identities = 102/301 (33%), Positives = 142/301 (47%), Gaps = 30/301 (9%)
Query: 433 AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
A CGG K + G I SP YP Y + C+W I+V G V L F +F+ E ++D
Sbjct: 1308 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1363
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
L V DG E+ L+ G P+ I ST + + ++F +D I+K+GFA+ F V
Sbjct: 1364 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1423
Query: 552 SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590
R P G + CDPGYEL ++R C A
Sbjct: 1424 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1483
Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
CGG LT +G I SP +P YP +++C W + Y ISL F F E N YDF+
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1539
Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQP 710
+ G ++S L G F S+ PE I S N M + F+SD +VS GF + ++ R +
Sbjct: 1540 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1599
Query: 711 P 711
P
Sbjct: 1600 P 1600
Score = 136 bits (343), Expect = 6e-32
Identities = 93/291 (31%), Positives = 140/291 (48%), Gaps = 32/291 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
C + G + SP+YP+ Y + CIW I G + L+F F++E +D+L
Sbjct: 617 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 672
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552
V+DG S S ++G + G E P + S S L L+F +D S++ GF + N F +EC
Sbjct: 673 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 731
Query: 553 RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591
P R G CE+ + T G+ +C D + +C A C
Sbjct: 732 DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 791
Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
GG + +G I SPGWP Y + NC W + A + I + F+ F+TE N YD +EV
Sbjct: 792 GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 847
Query: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
G S L G + G++ P+ + S N + + F +DN+ S GFK H+ S
Sbjct: 848 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYES 898
Score = 136 bits (343), Expect = 6e-32
Identities = 92/300 (30%), Positives = 146/300 (48%), Gaps = 32/300 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG + K G I SP YP+ Y + C+W+I V EG + + SF E + +D L+
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1890
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553
DG ++ +G Y G P + STS+ L+L F SD S++ AGF + + +D C
Sbjct: 1891 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 1950
Query: 554 PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592
P ++ + + S++C D GY L P +R C A CG
Sbjct: 1951 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2008
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G ++ +G I SPG+P YP + +C W + P + + LQF F TE +D++EVR
Sbjct: 2009 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2064
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712
SG + S + G+ G + P + S + + F SD + +K+GF + + + + PR
Sbjct: 2065 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPR 2124
Score = 136 bits (342), Expect = 8e-32
Identities = 98/300 (32%), Positives = 143/300 (47%), Gaps = 40/300 (13%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG++ G I SPN+P Y S+ C W I V+ + + L F SF IE + YD+
Sbjct: 1482 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1537
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
L + DG +S LIG + + P+ I+S+S+ + L F SDGS++ GF + + ++ E C
Sbjct: 1538 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1597
Query: 552 SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587
P R G + + +T+ Y CD GY L P R C
Sbjct: 1598 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Query: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
A CG T G++ SP +PK Y NC++ + P ++ + QF FF+T +DV
Sbjct: 1655 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1710
Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706
VEV G T S L GS E + S N + + F S ++ KGF HF + P
Sbjct: 1711 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1767
Score = 124 bits (311), Expect = 3e-28
Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493
CG +++ G SPN+P Y + C+W I V+ + + F+ F++E YD L
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 499
Query: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
+ DG + T++ G PD I S SS++WL +D S+ GF VN+ + E +
Sbjct: 500 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 559
Query: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593
C P G E + + C G+EL +K C C
Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 619
Query: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653
T G++ SP +P+ Y N NCIW +++ RI L F+ F+ E ++DF+ V+
Sbjct: 620 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 675
Query: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
G + +S + G F G+E P +TS + +R+EF++D+++S +GF
Sbjct: 676 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 718
Score = 115 bits (288), Expect = 1e-25
Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 38/295 (12%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG +K G I+SP +P Y C W I E + + FQSF +E YDYL
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
+ DGH + R G+ P + ST S L+ SD +++ GF V +++E+ S
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 179
Query: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589
N G + L + + SC GY L + R E
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239
Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
ACGG + +G I+SP +P EY N +C W +VA ISL F F+ E KYD++
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 295
Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704
E+ L G P I S N +R+ F +D+ +GF A + +K
Sbjct: 296 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKK 346
Score = 113 bits (283), Expect = 5e-25
Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG G I SP +P Y+ S C W I+ G + +TF+ F+ E + YD
Sbjct: 789 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 844
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549
LEV DG + S L+G Y G + P + S+S+ ++L F +D S + GF +++
Sbjct: 845 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 904
Query: 550 ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
C P G + + SCD GY L+ ++ C+A CG
Sbjct: 905 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 964
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G + +G+I SPG+P+ YP + NC W + + F F E + +D++ +
Sbjct: 965 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1020
Query: 653 SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700
+ L + GS+ P I + Y N R + F SD ++S +GF F
Sbjct: 1021 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1070
Score = 113 bits (282), Expect = 7e-25
Identities = 84/294 (28%), Positives = 128/294 (43%), Gaps = 35/294 (11%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CG G + SPNYP +Y C++ I V + F V F F+ HD
Sbjct: 1656 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1710
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
+EV DG ++ S+L+ G + + S+ +++ ++F S G I GF +
Sbjct: 1711 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1770
Query: 552 SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586
S E R +G S C+PGY E P+
Sbjct: 1771 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1830
Query: 587 CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
C CGG LTK G+I SPG+P+ Y N NC+W++ P I +Q F TE N +
Sbjct: 1831 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1886
Query: 647 DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
D ++ G ++ G + G+ P ++ S NN+ + F+SD +VS GF +
Sbjct: 1887 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 1940
Score = 105 bits (262), Expect = 1e-22
Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
+A+CGGDV+ G I SP YP+ Y S C W + V+ G V F +F +E H +D
Sbjct: 960 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1015
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
YL + + S + L R G + P I + + R L+F+SD SI+ GF + F +
Sbjct: 1016 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1074
Query: 548 VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
++ C P R G + SC GY L RC
Sbjct: 1075 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Query: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
A CG T G + SP +P Y N CI+ + I++ F DV K
Sbjct: 1135 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1191
Query: 649 VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
+ G + L G F G S + ++S N + +EF SD + +GF+ + S
Sbjct: 1192 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1244
Score = 100 bits (250), Expect = 4e-21
Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
EA+CGG++ G I SP YPD+Y + C W ++V G + + F + E YD
Sbjct: 2176 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2231
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549
++ V DG ++S IG++ G + + STS+++ +KF SD +GF V + ++
Sbjct: 2232 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2289
Query: 550 ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588
C P +CL +G+ +C G L D C+
Sbjct: 2290 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2349
Query: 589 AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
C +L+ G I SPG+P YP + C W + Y I++ +FF+TE ++
Sbjct: 2350 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2405
Query: 647 DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
D ++V G S + G ITS + + +++ +D+ +KKGF+ + +
Sbjct: 2406 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2462
Score = 85.1 bits (209), Expect = 2e-16
Identities = 91/327 (27%), Positives = 131/327 (40%), Gaps = 70/327 (21%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
E CGG ++ G I SP++P++Y + C W I G + L F F++E YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
YLE+ SE T+ G P I S + L L FV+D + GF+ + K +D
Sbjct: 294 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAID 349
Query: 550 ECSRP----------------NRGG---CEQRCLN--------------TLGS-YKCSCD 575
SR N GG C + +LGS + SCD
Sbjct: 350 FKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCD 409
Query: 576 PGYELAPDKR-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKN 616
Y L K C+ CG L +G+ TSP +P +Y N
Sbjct: 410 EDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQ 469
Query: 617 CIWQLVA-PTQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEV 673
C+W + A T I + F+ F+ E G D D EV T L G F P++
Sbjct: 470 CVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDL 525
Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHF 700
I S + M + ++D +V GFK ++
Sbjct: 526 IVSMSSQMWLHLQTDESVGSVGFKVNY 552
Score = 73.9 bits (180), Expect = 5e-13
Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%)
Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
G SP+YP GY +++C+W I PG +I L+F DL +D++ V+DG ++
Sbjct: 626 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 681
Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450
P+ G F G+++P + S L +EF++ + G+GF Y +GH + P+
Sbjct: 682 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 732
Score = 70.5 bits (171), Expect = 5e-12
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 8/141 (5%)
Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
CGG L LNG+I SPG+P YP NC W ++A + RI + F F E +YD++
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 120
Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPAL-- 708
+ G + + G P +TS + + SD VS GFK ++ + +
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 180
Query: 709 --QPPRGRPHQLKFRVQKRNR 727
PP+G + +F V + R
Sbjct: 181 PGVPPKGVLYGTRFDVGDKIR 201
Score = 67.4 bits (163), Expect = 4e-11
Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 8/112 (7%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG T++ S+G SSP +PN Y + C W I PG+ I L FT + YDY+
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 295
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
E+ P G +P PI+S + L + F + SN +GF A Y+
Sbjct: 296 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 64.3 bits (155), Expect = 4e-10
Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L +C A CG + G SP YP+ Y C W + V PG I +NFT L
Sbjct: 2172 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2229
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
YD++ V DG + +P G+F G+ E + ST +++ ++F S++ GFF +
Sbjct: 2230 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2281
Score = 62.8 bits (151), Expect = 1e-09
Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%)
Query: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312
EP+ + +G + S + ++ + Y + G K QR +
Sbjct: 387 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 434
Query: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371
R + K CG LQ +G F+SP +P Y ++ CVW I+ K+I +NF DL
Sbjct: 435 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 493
Query: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429
YD + + DG P + GS +P+ IVS S++W+ ++ + GF
Sbjct: 494 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 550
Query: 430 VYEAI----CGGDVKKDYG 444
Y+ I CG YG
Sbjct: 551 NYKEIEKESCGDPGTPLYG 569
Score = 62.4 bits (150), Expect = 1e-09
Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L S+G SP +P+ Y C W I+V I L F S + + YD++
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1539
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
+ DG +PL G F SKLPE I S+ + + + FRS + GF Y+A
Sbjct: 1540 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1591
Score = 61.2 bits (147), Expect = 3e-09
Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L G SP YP Y +++CVW+I+V G I + S + +D ++
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1890
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
DG AP G + G+ +P + ST + L++ F+S + GF Y AI
Sbjct: 1891 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 1943
Score = 60.8 bits (146), Expect = 4e-09
Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG + D +G SP +P Y + + C W I++ G + L F + S +DY+E
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2062
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
VR G + + GR G ++P + ST + F S + +GF VY+A
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2114
Score = 59.7 bits (143), Expect = 9e-09
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%)
Query: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502
G I SP YPD Y ++C W I V +G+++ + + F+ E+ +D L+V DG + +S
Sbjct: 2363 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2418
Query: 503 STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559
LI Y +I S ++L++ +D NK GF + + CS P G
Sbjct: 2419 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2476
Query: 560 EQRCLNTLGS-YKCSCDPGYEL 580
+ L S + +CD G+ L
Sbjct: 2477 ISQTGGQLNSVVRWACDRGFRL 2498
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Query: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
L G + + + KC A CG +G SP +P Y ++C W I PG I +
Sbjct: 773 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 832
Query: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
F + +++ L YD +EV DG +PL G + G+++P+ + S+ + +++ F + ++
Sbjct: 833 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 888
Query: 424 GKGFFAVYEAI 434
GF YE++
Sbjct: 889 NNGFKIHYESV 899
Score = 57.0 bits (136), Expect = 6e-08
Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L +C A CG + ++ G SP YP Y + C++ I V G+ I ++ + L +
Sbjct: 1130 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1187
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
D +++ DG + L G F G+ + + ST ++LW+EF S + +GF VY +
Sbjct: 1188 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1244
Query: 434 ICGGDVKKDYGHIQSPNYP 452
+ H + P P
Sbjct: 1245 F-------ELSHCEDPGIP 1256
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)
Query: 314 RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372
R L C A CG S G SP YP YS +CV+ I+V P E ++ F +++
Sbjct: 1649 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1705
Query: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431
L +D VEV DG +++ L GS E + +S+ +++ + F S KGF VY
Sbjct: 1706 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1763
Query: 432 EAI 434
+A+
Sbjct: 1764 QAV 1766
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%)
Query: 317 YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
Y P+C G +S+G SP YP Y ++ C+W I V PG + L F + D
Sbjct: 1301 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1360
Query: 372 SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
S +D + V DG L GS +PE I ST + + ++F + ++ K FA+
Sbjct: 1361 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1414
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG ++ +G SP YP Y ++C W + VT G+ + NF + L +DY+
Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1018
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
+ + PL R GS LP I ++ L+ FR+ ++
Sbjct: 1019 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1056
Score = 38.9 bits (89), Expect = 0.017
Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%)
Query: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
CPA E DSTG SP YP+ Y C W ISV G I + + +D
Sbjct: 2352 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2406
Query: 379 YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
++V DG ++P+ G I S +++++ + KGF Y A C
Sbjct: 2407 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2466
Query: 437 GDVKKDYGHIQS 448
+G+I S
Sbjct: 2467 TPESPPHGYIIS 2478
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 146 bits (369), Expect = 6e-35
Identities = 107/304 (35%), Positives = 146/304 (48%), Gaps = 29/304 (9%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG + G I SP +P +Y S C W I + GF V L F +F E +DY
Sbjct: 2109 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2164
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
LEVR G SE+ST+IGR G + P + ST+ L F SD S NK GF + + ++ C
Sbjct: 2165 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2224
Query: 552 S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592
RP R G T+G + C PGY L + RCEA CG
Sbjct: 2225 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2284
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G +T +NG+I SPG+P EYP ++C W + P I + F +TE YDF+ V
Sbjct: 2285 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2340
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712
G +S G+F G+ E + S N + ++F SD T S F + + + QPP
Sbjct: 2341 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRVCQPPP 2399
Query: 713 GRPH 716
P+
Sbjct: 2400 PVPN 2403
Score = 144 bits (364), Expect = 2e-34
Identities = 102/301 (33%), Positives = 142/301 (47%), Gaps = 30/301 (9%)
Query: 433 AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
A CGG K + G I SP YP Y + C+W I+V G V L F +F+ E ++D
Sbjct: 1412 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1467
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
L V DG E+ L+ G P+ I ST + + ++F +D I+K+GFA+ F V
Sbjct: 1468 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1527
Query: 552 SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590
R P G + CDPGYEL ++R C A
Sbjct: 1528 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1587
Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
CGG LT +G I SP +P YP +++C W + Y ISL F F E N YDF+
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1643
Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQP 710
+ G ++S L G F S+ PE I S N M + F+SD +VS GF + ++ R +
Sbjct: 1644 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1703
Query: 711 P 711
P
Sbjct: 1704 P 1704
Score = 136 bits (343), Expect = 6e-32
Identities = 93/291 (31%), Positives = 140/291 (48%), Gaps = 32/291 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
C + G + SP+YP+ Y + CIW I G + L+F F++E +D+L
Sbjct: 721 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 776
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552
V+DG S S ++G + G E P + S S L L+F +D S++ GF + N F +EC
Sbjct: 777 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 835
Query: 553 RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591
P R G CE+ + T G+ +C D + +C A C
Sbjct: 836 DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 895
Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
GG + +G I SPGWP Y + NC W + A + I + F+ F+TE N YD +EV
Sbjct: 896 GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 951
Query: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
G S L G + G++ P+ + S N + + F +DN+ S GFK H+ S
Sbjct: 952 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYES 1002
Score = 136 bits (343), Expect = 6e-32
Identities = 92/300 (30%), Positives = 146/300 (48%), Gaps = 32/300 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG + K G I SP YP+ Y + C+W+I V EG + + SF E + +D L+
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1994
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553
DG ++ +G Y G P + STS+ L+L F SD S++ AGF + + +D C
Sbjct: 1995 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 2054
Query: 554 PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592
P ++ + + S++C D GY L P +R C A CG
Sbjct: 2055 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2112
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G ++ +G I SPG+P YP + +C W + P + + LQF F TE +D++EVR
Sbjct: 2113 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2168
Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712
SG + S + G+ G + P + S + + F SD + +K+GF + + + + PR
Sbjct: 2169 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPR 2228
Score = 136 bits (342), Expect = 8e-32
Identities = 98/300 (32%), Positives = 143/300 (47%), Gaps = 40/300 (13%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG++ G I SPN+P Y S+ C W I V+ + + L F SF IE + YD+
Sbjct: 1586 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1641
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
L + DG +S LIG + + P+ I+S+S+ + L F SDGS++ GF + + ++ E C
Sbjct: 1642 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1701
Query: 552 SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587
P R G + + +T+ Y CD GY L P R C
Sbjct: 1702 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758
Query: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
A CG T G++ SP +PK Y NC++ + P ++ + QF FF+T +DV
Sbjct: 1759 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1814
Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706
VEV G T S L GS E + S N + + F S ++ KGF HF + P
Sbjct: 1815 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1871
Score = 124 bits (311), Expect = 3e-28
Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493
CG +++ G SPN+P Y + C+W I V+ + + F+ F++E YD L
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 603
Query: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
+ DG + T++ G PD I S SS++WL +D S+ GF VN+ + E +
Sbjct: 604 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 663
Query: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593
C P G E + + C G+EL +K C C
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723
Query: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653
T G++ SP +P+ Y N NCIW +++ RI L F+ F+ E ++DF+ V+
Sbjct: 724 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 779
Query: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
G + +S + G F G+E P +TS + +R+EF++D+++S +GF
Sbjct: 780 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 822
Score = 115 bits (287), Expect = 2e-25
Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG +K G I+SP +P Y C W I E + + FQSF +E YDYL
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
+ DGH + R G+ P + ST S L+ SD +++ GF V +++E+ S
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 179
Query: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589
N G + L + + SC GY L + R E
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239
Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
ACGG + +G I+SP +P EY N +C W +VA ISL F F+ E KYD++
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 295
Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
E+ L G P I S N +R+ F +D+ +GF A +
Sbjct: 296 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342
Score = 113 bits (283), Expect = 5e-25
Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CGG G I SP +P Y+ S C W I+ G + +TF+ F+ E + YD
Sbjct: 893 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 948
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549
LEV DG + S L+G Y G + P + S+S+ ++L F +D S + GF +++
Sbjct: 949 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 1008
Query: 550 ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
C P G + + SCD GY L+ ++ C+A CG
Sbjct: 1009 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 1068
Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
G + +G+I SPG+P+ YP + NC W + + F F E + +D++ +
Sbjct: 1069 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1124
Query: 653 SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700
+ L + GS+ P I + Y N R + F SD ++S +GF F
Sbjct: 1125 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1174
Score = 113 bits (282), Expect = 7e-25
Identities = 84/294 (28%), Positives = 128/294 (43%), Gaps = 35/294 (11%)
Query: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
A CG G + SPNYP +Y C++ I V + F V F F+ HD
Sbjct: 1760 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1814
Query: 493 LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
+EV DG ++ S+L+ G + + S+ +++ ++F S G I GF +
Sbjct: 1815 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1874
Query: 552 SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586
S E R +G S C+PGY E P+
Sbjct: 1875 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1934
Query: 587 CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
C CGG LTK G+I SPG+P+ Y N NC+W++ P I +Q F TE N +
Sbjct: 1935 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1990
Query: 647 DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
D ++ G ++ G + G+ P ++ S NN+ + F+SD +VS GF +
Sbjct: 1991 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 2044
Score = 105 bits (262), Expect = 1e-22
Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
+A+CGGDV+ G I SP YP+ Y S C W + V+ G V F +F +E H +D
Sbjct: 1064 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1119
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
YL + + S + L R G + P I + + R L+F+SD SI+ GF + F +
Sbjct: 1120 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1178
Query: 548 VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
++ C P R G + SC GY L RC
Sbjct: 1179 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Query: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
A CG T G + SP +P Y N CI+ + I++ F DV K
Sbjct: 1239 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1295
Query: 649 VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
+ G + L G F G S + ++S N + +EF SD + +GF+ + S
Sbjct: 1296 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1348
Score = 100 bits (250), Expect = 4e-21
Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
EA+CGG++ G I SP YPD+Y + C W ++V G + + F + E YD
Sbjct: 2280 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2335
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549
++ V DG ++S IG++ G + + STS+++ +KF SD +GF V + ++
Sbjct: 2336 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2393
Query: 550 ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588
C P +CL +G+ +C G L D C+
Sbjct: 2394 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2453
Query: 589 AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
C +L+ G I SPG+P YP + C W + Y I++ +FF+TE ++
Sbjct: 2454 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2509
Query: 647 DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
D ++V G S + G ITS + + +++ +D+ +KKGF+ + +
Sbjct: 2510 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2566
Score = 90.9 bits (224), Expect = 4e-18
Identities = 114/438 (26%), Positives = 176/438 (40%), Gaps = 79/438 (18%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
ACG T++ S+G SSP +PN Y + C W I PG+ I L FT + YDY+
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 295
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE-------A 433
E+ P G +P PI+S + L + F + SN +GF A Y+
Sbjct: 296 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 351
Query: 434 ICGGDVKK----DYGHIQSPNYPDDYRPSKVCIWRI-QVSEGFHVGLT-FQSFEIERHDS 487
G++++ G I + P D S V I ++SE V +T ++ ++ + S
Sbjct: 352 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 411
Query: 488 CAYDYLEVRDGHSESSTLIGRYC--------------GYEKPDDIKSTSSRLW------- 526
D L ++S+ R+ +K D KS +L+
Sbjct: 412 --KDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 469
Query: 527 -LKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGS-YKCSCDPGYELAPDK 584
+++G I A N + E R G + +LGS + SCD Y L K
Sbjct: 470 KFSILNEGGIKTAS---NLCPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAK 522
Query: 585 R-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-P 624
C+ CG L +G+ TSP +P +Y N C+W + A
Sbjct: 523 SITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVN 582
Query: 625 TQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMR 682
T I + F+ F+ E G D D EV T L G F P++I S + M
Sbjct: 583 TNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDLIVSMSSQMW 638
Query: 683 VEFKSDNTVSKKGFKAHF 700
+ ++D +V GFK ++
Sbjct: 639 LHLQTDESVGSVGFKVNY 656
Score = 73.9 bits (180), Expect = 5e-13
Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%)
Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
G SP+YP GY +++C+W I PG +I L+F DL +D++ V+DG ++
Sbjct: 730 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 785
Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450
P+ G F G+++P + S L +EF++ + G+GF Y +GH + P+
Sbjct: 786 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 836
Score = 70.5 bits (171), Expect = 5e-12
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 8/141 (5%)
Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
CGG L LNG+I SPG+P YP NC W ++A + RI + F F E +YD++
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 120
Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPAL-- 708
+ G + + G P +TS + + SD VS GFK ++ + +
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 180
Query: 709 --QPPRGRPHQLKFRVQKRNR 727
PP+G + +F V + R
Sbjct: 181 PGVPPKGVLYGTRFDVGDKIR 201
Score = 64.3 bits (155), Expect = 4e-10
Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L +C A CG + G SP YP+ Y C W + V PG I +NFT L
Sbjct: 2276 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2333
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
YD++ V DG + +P G+F G+ E + ST +++ ++F S++ GFF +
Sbjct: 2334 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2385
Score = 62.8 bits (151), Expect = 1e-09
Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%)
Query: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312
EP+ + +G + S + ++ + Y + G K QR +
Sbjct: 491 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 538
Query: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371
R + K CG LQ +G F+SP +P Y ++ CVW I+ K+I +NF DL
Sbjct: 539 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 597
Query: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429
YD + + DG P + GS +P+ IVS S++W+ ++ + GF
Sbjct: 598 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 654
Query: 430 VYEAI----CGGDVKKDYG 444
Y+ I CG YG
Sbjct: 655 NYKEIEKESCGDPGTPLYG 673
Score = 62.4 bits (150), Expect = 1e-09
Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L S+G SP +P+ Y C W I+V I L F S + + YD++
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1643
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
+ DG +PL G F SKLPE I S+ + + + FRS + GF Y+A
Sbjct: 1644 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1695
Score = 61.2 bits (147), Expect = 3e-09
Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L G SP YP Y +++CVW+I+V G I + S + +D ++
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1994
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
DG AP G + G+ +P + ST + L++ F+S + GF Y AI
Sbjct: 1995 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2047
Score = 60.8 bits (146), Expect = 4e-09
Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG + D +G SP +P Y + + C W I++ G + L F + S +DY+E
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2166
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
VR G + + GR G ++P + ST + F S + +GF VY+A
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2218
Score = 59.7 bits (143), Expect = 9e-09
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%)
Query: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502
G I SP YPD Y ++C W I V +G+++ + + F+ E+ +D L+V DG + +S
Sbjct: 2467 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2522
Query: 503 STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559
LI Y +I S ++L++ +D NK GF + + CS P G
Sbjct: 2523 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2580
Query: 560 EQRCLNTLGS-YKCSCDPGYEL 580
+ L S + +CD G+ L
Sbjct: 2581 ISQTGGQLNSVVRWACDRGFRL 2602
Score = 59.3 bits (142), Expect = 1e-08
Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 8/145 (5%)
Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
E CGG ++ G I SP++P++Y + C W I G + L F F++E YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
YLE+ SE T+ G P I S + L L FV+D + GF+ +
Sbjct: 294 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 349
Query: 552 SRPNRGGCEQRCLNTLGSYKCSCDP 576
+ G E+ T G+ + P
Sbjct: 350 HTTSTGELEEHNRTTTGAIAVASTP 374
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Query: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
L G + + + KC A CG +G SP +P Y ++C W I PG I +
Sbjct: 877 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 936
Query: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
F + +++ L YD +EV DG +PL G + G+++P+ + S+ + +++ F + ++
Sbjct: 937 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 992
Query: 424 GKGFFAVYEAI 434
GF YE++
Sbjct: 993 NNGFKIHYESV 1003
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG TL+ G SP +P GY +C W I +I + F S L YDY+
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
+ DG R R G LP P+ ST S + S GF YE +
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 173
Score = 57.0 bits (136), Expect = 6e-08
Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%)
Query: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
L +C A CG + ++ G SP YP Y + C++ I V G+ I ++ + L +
Sbjct: 1234 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1291
Query: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
D +++ DG + L G F G+ + + ST ++LW+EF S + +GF VY +
Sbjct: 1292 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1348
Query: 434 ICGGDVKKDYGHIQSPNYP 452
+ H + P P
Sbjct: 1349 F-------ELSHCEDPGIP 1360
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)
Query: 314 RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372
R L C A CG S G SP YP YS +CV+ I+V P E ++ F +++
Sbjct: 1753 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1809
Query: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431
L +D VEV DG +++ L GS E + +S+ +++ + F S KGF VY
Sbjct: 1810 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1867
Query: 432 EAI 434
+A+
Sbjct: 1868 QAV 1870
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%)
Query: 317 YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
Y P+C G +S+G SP YP Y ++ C+W I V PG + L F + D
Sbjct: 1405 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1464
Query: 372 SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
S +D + V DG L GS +PE I ST + + ++F + ++ K FA+
Sbjct: 1465 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1518
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG ++ +G SP YP Y ++C W + VT G+ + NF + L +DY+
Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1122
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
+ + PL R GS LP I ++ L+ FR+ ++
Sbjct: 1123 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1160
Score = 38.9 bits (89), Expect = 0.017
Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%)
Query: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
CPA E DSTG SP YP+ Y C W ISV G I + + +D
Sbjct: 2456 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2510
Query: 379 YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
++V DG ++P+ G I S +++++ + KGF Y A C
Sbjct: 2511 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2570
Query: 437 GDVKKDYGHIQS 448
+G+I S
Sbjct: 2571 TPESPPHGYIIS 2582
>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
precursor [Homo sapiens]
Length = 686
Score = 139 bits (351), Expect = 7e-33
Identities = 92/300 (30%), Positives = 144/300 (48%), Gaps = 30/300 (10%)
Query: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502
+G + SP +P +Y + W + G+ + L F F++E C YD++++ G
Sbjct: 27 FGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVL 86
Query: 503 STLIGRYCGYEKPDDIK--------STSSRLWLKFVSDGSINK--AGFAVNFFKE-VDEC 551
+TL CG E D + S S L + F SD S K GF + E +DEC
Sbjct: 87 ATL----CGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142
Query: 552 S-RPNRG-GCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWP 608
P C+ C N LG + CSC GY L +KR C A C G T+ +G ++SP +P
Sbjct: 143 QVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYP 202
Query: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFF--ETEGNDVCKYDFVEVRSGLTADSKLHGKF 665
+ YP +C + + + + L F + F ET +C YDF+++++ D + HG F
Sbjct: 203 RPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQT----DREEHGPF 258
Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPA---LQPPRGR--PHQLKF 720
CG P I ++ N + + F +D + G+K H+ S +P + PP G P Q K+
Sbjct: 259 CGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKY 318
Score = 92.4 bits (228), Expect = 1e-18
Identities = 99/398 (24%), Positives = 152/398 (38%), Gaps = 91/398 (22%)
Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
G +SP +P Y+ W ++ PG ++ L FT DL S LC YD+V++ G A
Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
Query: 391 PLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGKGFFAVY--------- 431
+ CG + + S S L + FRS S+ GF A Y
Sbjct: 84 KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
Query: 432 -------------------------------------EAICGGDV-KKDYGHIQSPNYPD 453
A+C G V + G + SP YP
Sbjct: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
Query: 454 DYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDS--CAYDYLEVRDGHSESSTLIGRYC 510
Y C + I + EGF V L F +SF++E H C YD+L+++ E G +C
Sbjct: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEH----GPFC 259
Query: 511 GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP-----NRGGCEQRCLN 565
G P I++ S+ + + FV+D S + G+ +++ C P Q
Sbjct: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYI 319
Query: 566 TLGSYKCSCDPGYELAPDK---RRCEAAC---GGFLTKLNG-SITSPGWPKEYPPNKNCI 618
S+ C+ GYEL + A C G + + SI G P + P + +
Sbjct: 320 LKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGR--V 377
Query: 619 WQLVAP--TQYRISLQFDFFET-------EGNDVCKYD 647
+ P T Y+ +Q+ ET +G VC+ D
Sbjct: 378 EYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEAD 415
Score = 62.8 bits (151), Expect = 1e-09
Identities = 41/131 (31%), Positives = 64/131 (48%), Gaps = 22/131 (16%)
Query: 591 CGGFLTKLN--------GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGND 642
CG T L G + SPG+P EY ++ W L AP YR+ L F F+ E +
Sbjct: 11 CGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSH 70
Query: 643 VCKYDFVEVRSGLTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSDNTVSK- 693
+C+YDFV++ SG +K+ CG E + S +++ + F+SD + K
Sbjct: 71 LCEYDFVKLSSG----AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP 126
Query: 694 -KGFKAHFFSE 703
GF+A + +E
Sbjct: 127 FTGFEAFYAAE 137
Score = 51.6 bits (122), Expect = 3e-06
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 7/97 (7%)
Query: 323 GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT---SLDLYRSRLCWYDY 379
G+ +G SSPEYP Y C + IS+ G +IL+F ++ + LC YD+
Sbjct: 186 GQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDF 245
Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEF 416
++++ P FCG LP I + + + + F
Sbjct: 246 LKIQTDREEHGP----FCGKTLPHRIETKSNTVTITF 278
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 139 bits (350), Expect = 9e-33
Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)
Query: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
CG+T++ +S G +SP YP+ Y C W I P ++I++NF R C YDY
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
VEV DG RG+FCG P P+VS+ L+++F S G GF YE
Sbjct: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
C + G I+SP +P+ Y S C + + + + L F+SF++E + C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
YD LE+ DG + IGRYCG + P I+S+S L + F +D +I K GF+ N+
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Score = 129 bits (323), Expect = 1e-29
Identities = 82/277 (29%), Positives = 132/277 (47%), Gaps = 52/277 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
CG +K + G++ SP YP Y PS+ C W IQ + + + + F F++E D C YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
Y+EV DG +E+ G++CG P + S+ L++KFVSD + AGF++ + FK
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
ECS+ T +G I SPG+P+
Sbjct: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP + C + + AP I L+F+ F+ E G C+YD +E+ G G
Sbjct: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
++CG + P I S + + F +D+ ++K+GF A++
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Score = 72.8 bits (177), Expect = 1e-12
Identities = 41/108 (37%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 600 GSITSPGWPKEYPPNKNCIWQLVAPTQY-RISLQFD-FFETEGNDVCKYDFVEVRSGLTA 657
G +TSPG+P Y P++ C W + AP Y RI + F+ F+ E D CKYD+VEV G
Sbjct: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
Query: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKR 705
+ GKFCG P + S + ++F SD GF + KR
Sbjct: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)
Query: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
P C + +G SP +P Y + C + + +IIL F S DL
Sbjct: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
Query: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
C YD +E+ DGF P GR+CG K P I S+ L + F + S +GF A Y +
Sbjct: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
Query: 434 ICGGDVKKDY 443
+ V +D+
Sbjct: 264 VLQSSVSEDF 273
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 139 bits (350), Expect = 9e-33
Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)
Query: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
CG+T++ +S G +SP YP+ Y C W I P ++I++NF R C YDY
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
VEV DG RG+FCG P P+VS+ L+++F S G GF YE
Sbjct: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
C + G I+SP +P+ Y S C + + + + L F+SF++E + C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
YD LE+ DG + IGRYCG + P I+S+S L + F +D +I K GF+ N+
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Score = 129 bits (323), Expect = 1e-29
Identities = 82/277 (29%), Positives = 132/277 (47%), Gaps = 52/277 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
CG +K + G++ SP YP Y PS+ C W IQ + + + + F F++E D C YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
Y+EV DG +E+ G++CG P + S+ L++KFVSD + AGF++ + FK
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
ECS+ T +G I SPG+P+
Sbjct: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP + C + + AP I L+F+ F+ E G C+YD +E+ G G
Sbjct: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
++CG + P I S + + F +D+ ++K+GF A++
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Score = 72.8 bits (177), Expect = 1e-12
Identities = 41/108 (37%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 600 GSITSPGWPKEYPPNKNCIWQLVAPTQY-RISLQFD-FFETEGNDVCKYDFVEVRSGLTA 657
G +TSPG+P Y P++ C W + AP Y RI + F+ F+ E D CKYD+VEV G
Sbjct: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
Query: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKR 705
+ GKFCG P + S + ++F SD GF + KR
Sbjct: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)
Query: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
P C + +G SP +P Y + C + + +IIL F S DL
Sbjct: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
Query: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
C YD +E+ DGF P GR+CG K P I S+ L + F + S +GF A Y +
Sbjct: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
Query: 434 ICGGDVKKDY 443
+ V +D+
Sbjct: 264 VLQSSVSEDF 273
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 139 bits (350), Expect = 9e-33
Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)
Query: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
CG+T++ +S G +SP YP+ Y C W I P ++I++NF R C YDY
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
VEV DG RG+FCG P P+VS+ L+++F S G GF YE
Sbjct: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
C + G I+SP +P+ Y S C + + + + L F+SF++E + C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
YD LE+ DG + IGRYCG + P I+S+S L + F +D +I K GF+ N+
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Score = 129 bits (323), Expect = 1e-29
Identities = 82/277 (29%), Positives = 132/277 (47%), Gaps = 52/277 (18%)
Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
CG +K + G++ SP YP Y PS+ C W IQ + + + + F F++E D C YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
Y+EV DG +E+ G++CG P + S+ L++KFVSD + AGF++ + FK
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
ECS+ T +G I SPG+P+
Sbjct: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
+YP + C + + AP I L+F+ F+ E G C+YD +E+ G G
Sbjct: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
++CG + P I S + + F +D+ ++K+GF A++
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Score = 72.8 bits (177), Expect = 1e-12
Identities = 41/108 (37%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 600 GSITSPGWPKEYPPNKNCIWQLVAPTQY-RISLQFD-FFETEGNDVCKYDFVEVRSGLTA 657
G +TSPG+P Y P++ C W + AP Y RI + F+ F+ E D CKYD+VEV G
Sbjct: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
Query: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKR 705
+ GKFCG P + S + ++F SD GF + KR
Sbjct: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)
Query: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
P C + +G SP +P Y + C + + +IIL F S DL
Sbjct: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
Query: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
C YD +E+ DGF P GR+CG K P I S+ L + F + S +GF A Y +
Sbjct: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
Query: 434 ICGGDVKKDY 443
+ V +D+
Sbjct: 264 VLQSSVSEDF 273
>gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]
Length = 1662
Score = 138 bits (348), Expect = 2e-32
Identities = 107/386 (27%), Positives = 170/386 (44%), Gaps = 40/386 (10%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L ++G FSSP YP Y + CVW I V G +I L F++L L C +DYVE
Sbjct: 1015 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1074
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
+ DG + L G+ C + S+ +R+ + FRS ++ GF A Y +
Sbjct: 1075 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDAT-- 1131
Query: 442 DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ-SFEIERHDSCAYDYLEVRDGHS 500
++ N Y +C R+++ G G S+ I+ + R +
Sbjct: 1132 ----LRLVNLNSSYG---LCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSA 1184
Query: 501 ESSTLIGRYCGYEKPDDIK--STSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
+ G G DD++ T S LW N+ F+ N C+ G
Sbjct: 1185 LGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHN-------CNHREDAG 1231
Query: 559 --CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
C L+T P L + + +CGGFL++ +G +SP +P YP N
Sbjct: 1232 VICSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAK 1282
Query: 617 CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
C+W + YR+++ F + EG C YD++EV G S L + C + TS
Sbjct: 1283 CVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGS-FTS 1339
Query: 677 QYNNMRVEFKSDNTVSKKGFKAHFFS 702
N M + F SD++++++GF+A ++S
Sbjct: 1340 SSNFMSIRFISDHSITRRGFRAEYYS 1365
Score = 90.5 bits (223), Expect = 5e-18
Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 1/117 (0%)
Query: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
R + CGGFL +G+ +SP +P YP N C+W++ + YRI+L F + E + C
Sbjct: 1010 RPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCS 1069
Query: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
+D+VE+ G S L GK C + ++ TS YN M + F+SD + GF A + S
Sbjct: 1070 FDYVEIFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1125
Score = 77.8 bits (190), Expect = 3e-14
Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 9/130 (6%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG + + G SP YP +Y + C+W I+V + V + F+ ++E C YDY+E
Sbjct: 1257 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 1314
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
V DG SS LI R C + S+S+ + ++F+SD SI + GF ++ S P
Sbjct: 1315 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYY------SSP 1367
Query: 555 NRGGCEQRCL 564
+ CL
Sbjct: 1368 SNDSTNLLCL 1377
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 3/111 (2%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
+CG L +G+FSSP YP Y + CVW I V ++ + F + L C YDY+
Sbjct: 1256 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYI 1313
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
EV DG +R +PL R C S+ + + + F S + +GF A Y
Sbjct: 1314 EVFDGPYRSSPLIARVCDGARGS-FTSSSNFMSIRFISDHSITRRGFRAEY 1363
>gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]
Length = 1788
Score = 138 bits (348), Expect = 2e-32
Identities = 107/386 (27%), Positives = 170/386 (44%), Gaps = 40/386 (10%)
Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
CG L ++G FSSP YP Y + CVW I V G +I L F++L L C +DYVE
Sbjct: 1141 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1200
Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
+ DG + L G+ C + S+ +R+ + FRS ++ GF A Y +
Sbjct: 1201 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDAT-- 1257
Query: 442 DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ-SFEIERHDSCAYDYLEVRDGHS 500
++ N Y +C R+++ G G S+ I+ + R +
Sbjct: 1258 ----LRLVNLNSSYG---LCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSA 1310
Query: 501 ESSTLIGRYCGYEKPDDIK--STSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
+ G G DD++ T S LW N+ F+ N C+ G
Sbjct: 1311 LGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHN-------CNHREDAG 1357
Query: 559 --CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
C L+T P L + + +CGGFL++ +G +SP +P YP N
Sbjct: 1358 VICSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAK 1408
Query: 617 CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
C+W + YR+++ F + EG C YD++EV G S L + C + TS
Sbjct: 1409 CVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGS-FTS 1465
Query: 677 QYNNMRVEFKSDNTVSKKGFKAHFFS 702
N M + F SD++++++GF+A ++S
Sbjct: 1466 SSNFMSIRFISDHSITRRGFRAEYYS 1491
Score = 90.5 bits (223), Expect = 5e-18
Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 1/117 (0%)
Query: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
R + CGGFL +G+ +SP +P YP N C+W++ + YRI+L F + E + C
Sbjct: 1136 RPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCS 1195
Query: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
+D+VE+ G S L GK C + ++ TS YN M + F+SD + GF A + S
Sbjct: 1196 FDYVEIFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1251
Score = 77.8 bits (190), Expect = 3e-14
Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 9/130 (6%)
Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
CGG + + G SP YP +Y + C+W I+V + V + F+ ++E C YDY+E
Sbjct: 1383 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 1440
Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
V DG SS LI R C + S+S+ + ++F+SD SI + GF ++ S P
Sbjct: 1441 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYY------SSP 1493
Query: 555 NRGGCEQRCL 564
+ CL
Sbjct: 1494 SNDSTNLLCL 1503
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 3/111 (2%)
Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
+CG L +G+FSSP YP Y + CVW I V ++ + F + L C YDY+
Sbjct: 1382 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYI 1439
Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
EV DG +R +PL R C S+ + + + F S + +GF A Y
Sbjct: 1440 EVFDGPYRSSPLIARVCDGARGS-FTSSSNFMSIRFISDHSITRRGFRAEY 1489
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,230,903
Number of Sequences: 37866
Number of extensions: 1572356
Number of successful extensions: 6752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 4784
Number of HSP's gapped (non-prelim): 1332
length of query: 730
length of database: 18,247,518
effective HSP length: 110
effective length of query: 620
effective length of database: 14,082,258
effective search space: 8730999960
effective search space used: 8730999960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.