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Search of human proteins with 45007007
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45007007 2'-5'oligoadenylate synthetase 3 [Homo sapiens]
(1087 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45007007 2'-5'oligoadenylate synthetase 3 [Homo sapiens] 2230 0.0
gi|74229017 2'-5'-oligoadenylate synthetase 2 isoform 2 [Homo sa... 575 e-164
gi|74229019 2'-5'-oligoadenylate synthetase 2 isoform 1 [Homo sa... 574 e-163
gi|74229015 2',5'-oligoadenylate synthetase 1 isoform 3 [Homo sa... 389 e-108
gi|74229013 2',5'-oligoadenylate synthetase 1 isoform 1 [Homo sa... 389 e-108
gi|74229011 2',5'-oligoadenylate synthetase 1 isoform 2 [Homo sa... 389 e-108
gi|11321577 2'-5'-oligoadenylate synthetase-like isoform a [Homo... 266 8e-71
gi|38016930 2'-5'-oligoadenylate synthetase-like isoform b [Homo... 147 7e-35
gi|74229021 2'-5'-oligoadenylate synthetase 2 isoform 3 [Homo sa... 71 6e-12
gi|17975763 myelin transcription factor 1 [Homo sapiens] 37 0.13
gi|21071060 SWI/SNF-related matrix-associated actin-dependent re... 36 0.23
gi|187761314 SWI/SNF-related matrix-associated actin-dependent r... 36 0.23
gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens] 35 0.30
gi|197116386 5'-nucleotidase domain containing 2 isoform 1 [Homo... 35 0.30
gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens] 35 0.50
gi|208022661 hypothetical protein LOC57701 [Homo sapiens] 34 0.66
gi|116734702 homeobox D13 [Homo sapiens] 33 1.9
gi|169215453 PREDICTED: hypothetical protein [Homo sapiens] 32 4.3
gi|169215350 PREDICTED: hypothetical protein [Homo sapiens] 32 4.3
gi|239756829 PREDICTED: zinc finger protein 385C [Homo sapiens] 31 5.6
gi|239751322 PREDICTED: zinc finger protein 385C [Homo sapiens] 31 5.6
gi|239745821 PREDICTED: zinc finger protein 385C [Homo sapiens] 31 5.6
gi|126116581 retina and anterior neural fold homeobox [Homo sapi... 31 5.6
gi|145977194 hypothetical protein LOC400793 isoform 2 [Homo sapi... 31 5.6
gi|207028635 hypothetical protein LOC400793 isoform 1 [Homo sapi... 31 5.6
gi|42544243 dynamin 3 isoform a [Homo sapiens] 31 5.6
gi|209915561 dynamin 3 isoform b [Homo sapiens] 31 5.6
gi|195963410 MEF2 activating motif and SAP domain containing tra... 31 7.3
gi|32698970 MEF2 activating motif and SAP domain containing tran... 31 7.3
gi|50233787 nuclear protein in testis [Homo sapiens] 31 7.3
>gi|45007007 2'-5'oligoadenylate synthetase 3 [Homo sapiens]
Length = 1087
Score = 2230 bits (5779), Expect = 0.0
Identities = 1087/1087 (100%), Positives = 1087/1087 (100%)
Query: 1 MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG 60
MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG
Sbjct: 1 MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG 60
Query: 61 GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF 120
GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF
Sbjct: 61 GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF 120
Query: 121 PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEH 180
PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEH
Sbjct: 121 PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEH 180
Query: 181 AACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQG 240
AACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQG
Sbjct: 181 AACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQG 240
Query: 241 CKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPAD 300
CKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPAD
Sbjct: 241 CKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPAD 300
Query: 301 PTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLD 360
PTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLD
Sbjct: 301 PTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLD 360
Query: 361 PNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI 420
PNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI
Sbjct: 361 PNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI 420
Query: 421 QDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFL 480
QDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFL
Sbjct: 421 QDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFL 480
Query: 481 NCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSW 540
NCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSW
Sbjct: 481 NCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSW 540
Query: 541 TDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKN 600
TDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKN
Sbjct: 541 TDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKN 600
Query: 601 LILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLG 660
LILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLG
Sbjct: 601 LILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLG 660
Query: 661 LVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEA 720
LVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEA
Sbjct: 661 LVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEA 720
Query: 721 AALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTI 780
AALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTI
Sbjct: 721 AALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTI 780
Query: 781 CSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEII 840
CSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEII
Sbjct: 781 CSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEII 840
Query: 841 SEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLV 900
SEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLV
Sbjct: 841 SEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLV 900
Query: 901 SGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKIS 960
SGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKIS
Sbjct: 901 SGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKIS 960
Query: 961 KGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKD 1020
KGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKD
Sbjct: 961 KGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKD 1020
Query: 1021 KTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQP 1080
KTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQP
Sbjct: 1021 KTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQP 1080
Query: 1081 WPVKAAV 1087
WPVKAAV
Sbjct: 1081 WPVKAAV 1087
>gi|74229017 2'-5'-oligoadenylate synthetase 2 isoform 2 [Homo
sapiens]
Length = 687
Score = 575 bits (1482), Expect = e-164
Identities = 337/703 (47%), Positives = 446/703 (63%), Gaps = 47/703 (6%)
Query: 408 LSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHE-NCVHKASRVSKGGSFGRGT 466
LS +P ++L FIQ++LKP + Q + + ++ I L E V+ GGS+GR T
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIGGSYGRKT 67
Query: 467 DLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLE-----SWWQDQVPSLSLQFPE 521
LR D L++F + ++DQ + +ILD+ +L+ W L F
Sbjct: 68 VLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKW-------LKNNFEI 120
Query: 522 QNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTS----GCQEG 577
Q + Q+ + + +V L AF+A LS P+P +Y L S G
Sbjct: 121 QKSLDGFTIQVFTKNQRISFEV--LAAFNA---LSLNDNPSPWIYRELKRSLDKTNASPG 175
Query: 578 EHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTI 637
E CF EL++ F + RP KLK+LILL+KHW++Q + K SL P YALELLT+
Sbjct: 176 EFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDL----PSLSP-YALELLTV 230
Query: 638 FAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPL 697
+AWEQGCR+D F++A+G RTVL L++ ++LC+YW VNY+ ED +R LL QL+ RP+
Sbjct: 231 YAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPV 290
Query: 698 VLDPADPTWNVGHGS--WELLAQEAAALGMQACFLSRDGTSVQP---WDVMPALLYQTPA 752
+LDP DPT NV W+ L +EA Q S + + P W+V+PA L+ TP
Sbjct: 291 ILDPVDPTNNVSGDKICWQWLKKEA-----QTWLTSPNLDNELPAPSWNVLPAPLFTTPG 345
Query: 753 GDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNSPIKVIKVVKGGSSAKGTALR 812
LDKFI EFLQPN+ FL Q++ AV+ I +FLKENCFR S K I++V+GGS+AKGTAL+
Sbjct: 346 HLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAK-IQIVRGGSTAKGTALK 404
Query: 813 GRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEAC--QQERQFEVKFEVSKWENPRV 870
SDADLVVF + +T Q N+R +I+ EI QL+A ++E + EV FE KW+ PRV
Sbjct: 405 TGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRV 464
Query: 871 LSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNA----GEYSTC 926
LSFSL S+ +L++SV FDVLPAF+ALGQL SGS PS +VY LI Y ++ GE+STC
Sbjct: 465 LSFSLKSK-VLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTC 523
Query: 927 FTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYAWEQGGKD 986
FT LQR+FI SRPTKLK LIRLVKHWY++C + K +GSLPP++ LELLT+YAWEQG
Sbjct: 524 FTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGV 583
Query: 987 SQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIILDPADPTG 1046
F+ AEGFRTVLELVTQY+QLCI+W +NYN +D+TV FL QLQK RP+ILDPA+PTG
Sbjct: 584 PDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTG 643
Query: 1047 NLGHNAR--WDLLAKEAAACTSALCCMGRNGIPIQPWPVKAAV 1087
++G R W LLAKEA S+ C G PI PW V V
Sbjct: 644 DVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVPVKV 686
Score = 445 bits (1145), Expect = e-125
Identities = 287/764 (37%), Positives = 398/764 (52%), Gaps = 113/764 (14%)
Query: 3 LYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKGGS 62
L S PA L F+ L+P +E + + L+E P V GGS
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEP-----EQFPLVQGVAIGGS 62
Query: 63 SGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLE-----SWWQNPVPGLR 117
GR T L+G D LV+F K + DQ+ + +IL + L+ W +N
Sbjct: 63 YGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFE--- 119
Query: 118 LTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNS---- 173
++S+ G F + + ++ AFN L + P P +Y L S
Sbjct: 120 ---IQKSLDG---FTIQVFTKNQRISFEVLAAFNALSLNDN---PSPWIYRELKRSLDKT 170
Query: 174 GCQGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPV--YALEL 231
GE A CFTEL++ F + RP KLK+LILL+KHW HQ C + + + LP + YALEL
Sbjct: 171 NASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHW-HQQCQKKI--KDLPSLSPYALEL 227
Query: 232 LTIFAWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRP 291
LT++AWEQGC+KD F +AEG+RTVL LI+ + LC++W VNY FED + L QL+
Sbjct: 228 LTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSA 287
Query: 292 RPVILDPADPTWDL-GNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGC 350
RPVILDP DPT ++ G+ W W L +EA Q+W
Sbjct: 288 RPVILDPVDPTNNVSGDKICWQW--LKKEA-----------------QTWL--------- 319
Query: 351 SGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQ 410
PN + S N + PAP L
Sbjct: 320 --------TSPNLDNELPAPSWNVL-----------PAP------------------LFT 342
Query: 411 IPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKAS---RVSKGGSFGRGTD 467
P LD+FI++ L+P+ F EQ+ A++II L ENC +++ ++ +GGS +GT
Sbjct: 343 TPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTA 402
Query: 468 LRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQF--PEQNVP 525
L+ G D +L++F N Y Q R +I+ E+ QL+++W+++ L + F P+ P
Sbjct: 403 LKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAP 462
Query: 526 EALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLL----TSGCQEGEHKA 581
L F L S L +LPAF+A+GQLSSG+ P+P+VY+ L+ +S GE
Sbjct: 463 RVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFST 522
Query: 582 CFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWE 641
CF L+RNF+ RP KLK+LI LVKHWY++ + K KG SLPP YALELLTI+AWE
Sbjct: 523 CFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKG----SLPPKYALELLTIYAWE 578
Query: 642 QGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDP 701
QG F+ A+GFRTVL LV Q+QQLC++W VNY+ ED +R LL QL+K RP++LDP
Sbjct: 579 QGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDP 638
Query: 702 ADPTWNVGHGS---WELLAQEAAALGMQACFLSRDGTSVQPWDV 742
A+PT +VG G W LLA+EA CF G + PW V
Sbjct: 639 AEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKV 682
Score = 302 bits (774), Expect = 1e-81
Identities = 159/347 (45%), Positives = 215/347 (61%), Gaps = 9/347 (2%)
Query: 3 LYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKGGS 62
L++TP LD+F+ LQP K F+E+ A+ + L+E R A ++ V+GGS
Sbjct: 340 LFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAK---IQIVRGGS 396
Query: 63 SGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF-- 120
+ +GTALK G D++LV+F + KSY Q+ R +I+ E+ L+++W+ L ++F
Sbjct: 397 TAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEP 456
Query: 121 PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLN----SGCQ 176
P+ P L F L S L + + ++PAFN LGQ SG P P+VY+ L++ S
Sbjct: 457 PKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLP 516
Query: 177 GGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFA 236
GGE + CFT L+RNF+ RP KLK+LI LVKHWY + + K +LPP YALELLTI+A
Sbjct: 517 GGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYA 576
Query: 237 WEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVIL 296
WEQG F AEG RTVL L+ Q+Q LC+FW VNY FED V +FL QL++ RPVIL
Sbjct: 577 WEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVIL 636
Query: 297 DPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGP 343
DPA+PT D+G G W W LLA+EA PCF G G+P+ WK P
Sbjct: 637 DPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVP 683
>gi|74229019 2'-5'-oligoadenylate synthetase 2 isoform 1 [Homo
sapiens]
Length = 719
Score = 574 bits (1480), Expect = e-163
Identities = 336/699 (48%), Positives = 445/699 (63%), Gaps = 47/699 (6%)
Query: 408 LSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHE-NCVHKASRVSKGGSFGRGT 466
LS +P ++L FIQ++LKP + Q + + ++ I L E V+ GGS+GR T
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIGGSYGRKT 67
Query: 467 DLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLE-----SWWQDQVPSLSLQFPE 521
LR D L++F + ++DQ + +ILD+ +L+ W L F
Sbjct: 68 VLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKW-------LKNNFEI 120
Query: 522 QNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTS----GCQEG 577
Q + Q+ + + +V L AF+A LS P+P +Y L S G
Sbjct: 121 QKSLDGFTIQVFTKNQRISFEV--LAAFNA---LSLNDNPSPWIYRELKRSLDKTNASPG 175
Query: 578 EHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTI 637
E CF EL++ F + RP KLK+LILL+KHW++Q + K SL P YALELLT+
Sbjct: 176 EFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDL----PSLSP-YALELLTV 230
Query: 638 FAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPL 697
+AWEQGCR+D F++A+G RTVL L++ ++LC+YW VNY+ ED +R LL QL+ RP+
Sbjct: 231 YAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPV 290
Query: 698 VLDPADPTWNVGHGS--WELLAQEAAALGMQACFLSRDGTSVQP---WDVMPALLYQTPA 752
+LDP DPT NV W+ L +EA Q S + + P W+V+PA L+ TP
Sbjct: 291 ILDPVDPTNNVSGDKICWQWLKKEA-----QTWLTSPNLDNELPAPSWNVLPAPLFTTPG 345
Query: 753 GDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNSPIKVIKVVKGGSSAKGTALR 812
LDKFI EFLQPN+ FL Q++ AV+ I +FLKENCFR S K I++V+GGS+AKGTAL+
Sbjct: 346 HLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAK-IQIVRGGSTAKGTALK 404
Query: 813 GRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEAC--QQERQFEVKFEVSKWENPRV 870
SDADLVVF + +T Q N+R +I+ EI QL+A ++E + EV FE KW+ PRV
Sbjct: 405 TGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRV 464
Query: 871 LSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNA----GEYSTC 926
LSFSL S+ +L++SV FDVLPAF+ALGQL SGS PS +VY LI Y ++ GE+STC
Sbjct: 465 LSFSLKSK-VLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTC 523
Query: 927 FTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYAWEQGGKD 986
FT LQR+FI SRPTKLK LIRLVKHWY++C + K +GSLPP++ LELLT+YAWEQG
Sbjct: 524 FTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGV 583
Query: 987 SQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIILDPADPTG 1046
F+ AEGFRTVLELVTQY+QLCI+W +NYN +D+TV FL QLQK RP+ILDPA+PTG
Sbjct: 584 PDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTG 643
Query: 1047 NLGHNAR--WDLLAKEAAACTSALCCMGRNGIPIQPWPV 1083
++G R W LLAKEA S+ C G PI PW V
Sbjct: 644 DVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKV 682
Score = 446 bits (1146), Expect = e-125
Identities = 291/773 (37%), Positives = 403/773 (52%), Gaps = 116/773 (15%)
Query: 3 LYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKGGS 62
L S PA L F+ L+P +E + + L+E P V GGS
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEP-----EQFPLVQGVAIGGS 62
Query: 63 SGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLE-----SWWQNPVPGLR 117
GR T L+G D LV+F K + DQ+ + +IL + L+ W +N
Sbjct: 63 YGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFE--- 119
Query: 118 LTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNS---- 173
++S+ G F + + ++ AFN L + P P +Y L S
Sbjct: 120 ---IQKSLDG---FTIQVFTKNQRISFEVLAAFNALSLNDN---PSPWIYRELKRSLDKT 170
Query: 174 GCQGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPV--YALEL 231
GE A CFTEL++ F + RP KLK+LILL+KHW HQ C + + + LP + YALEL
Sbjct: 171 NASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHW-HQQCQKKI--KDLPSLSPYALEL 227
Query: 232 LTIFAWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRP 291
LT++AWEQGC+KD F +AEG+RTVL LI+ + LC++W VNY FED + L QL+
Sbjct: 228 LTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSA 287
Query: 292 RPVILDPADPTWDL-GNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGC 350
RPVILDP DPT ++ G+ W W L +EA Q+W
Sbjct: 288 RPVILDPVDPTNNVSGDKICWQW--LKKEA-----------------QTWL--------- 319
Query: 351 SGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQ 410
PN + S N + PAP L
Sbjct: 320 --------TSPNLDNELPAPSWNVL-----------PAP------------------LFT 342
Query: 411 IPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKAS---RVSKGGSFGRGTD 467
P LD+FI++ L+P+ F EQ+ A++II L ENC +++ ++ +GGS +GT
Sbjct: 343 TPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTA 402
Query: 468 LRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQF--PEQNVP 525
L+ G D +L++F N Y Q R +I+ E+ QL+++W+++ L + F P+ P
Sbjct: 403 LKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAP 462
Query: 526 EALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLL----TSGCQEGEHKA 581
L F L S L +LPAF+A+GQLSSG+ P+P+VY+ L+ +S GE
Sbjct: 463 RVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFST 522
Query: 582 CFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWE 641
CF L+RNF+ RP KLK+LI LVKHWY++ + K KG SLPP YALELLTI+AWE
Sbjct: 523 CFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKG----SLPPKYALELLTIYAWE 578
Query: 642 QGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDP 701
QG F+ A+GFRTVL LV Q+QQLC++W VNY+ ED +R LL QL+K RP++LDP
Sbjct: 579 QGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDP 638
Query: 702 ADPTWNVGHGS---WELLAQEAAALGMQACFLSRDGTSVQPWDVMPALLYQTP 751
A+PT +VG G W LLA+EA CF G + PW V P + QTP
Sbjct: 639 AEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKV-PTM--QTP 688
Score = 307 bits (787), Expect = 3e-83
Identities = 164/362 (45%), Positives = 221/362 (61%), Gaps = 10/362 (2%)
Query: 3 LYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKGGS 62
L++TP LD+F+ LQP K F+E+ A+ + L+E R A ++ V+GGS
Sbjct: 340 LFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAK---IQIVRGGS 396
Query: 63 SGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF-- 120
+ +GTALK G D++LV+F + KSY Q+ R +I+ E+ L+++W+ L ++F
Sbjct: 397 TAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEP 456
Query: 121 PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLN----SGCQ 176
P+ P L F L S L + + ++PAFN LGQ SG P P+VY+ L++ S
Sbjct: 457 PKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLP 516
Query: 177 GGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFA 236
GGE + CFT L+RNF+ RP KLK+LI LVKHWY + + K +LPP YALELLTI+A
Sbjct: 517 GGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYA 576
Query: 237 WEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVIL 296
WEQG F AEG RTVL L+ Q+Q LC+FW VNY FED V +FL QL++ RPVIL
Sbjct: 577 WEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVIL 636
Query: 297 DPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAG-CSGLGH 355
DPA+PT D+G G W W LLA+EA PCF G G+P+ WK P + G C H
Sbjct: 637 DPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVPTMQTPGSCGARIH 696
Query: 356 PI 357
PI
Sbjct: 697 PI 698
>gi|74229015 2',5'-oligoadenylate synthetase 1 isoform 3 [Homo
sapiens]
Length = 414
Score = 389 bits (999), Expect = e-108
Identities = 206/344 (59%), Positives = 243/344 (70%), Gaps = 13/344 (3%)
Query: 747 LYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNS--PIKVIKVVKGGS 804
L TPA LDKFI ++L P+ F Q+N A+D IC FLKE CFR S P+ V KVVKGGS
Sbjct: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
Query: 805 SAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVS- 863
S KGT LRGRSDADLVVFLS + F +Q N+R E I EIR QLEACQ+ER F VKFEV
Sbjct: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
Query: 864 -KWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNA-- 920
+W NPR LSF L+S L + V+FDVLPAFDALGQL G +P+ Q+YV LI ++
Sbjct: 124 PRWGNPRALSFVLSS-LQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQK 182
Query: 921 -GEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYA 979
GE+STCFTELQRDF+ RPTKLKSLIRLVKHWYQ C K G LPPQ+ LELLTVYA
Sbjct: 183 EGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNC---KKKLGKLPPQYALELLTVYA 239
Query: 980 WEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIIL 1039
WE+G + FN A+GFRTVLELV Y+QLCIYWT Y+ K+ + +L++QL KPRP+IL
Sbjct: 240 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL 299
Query: 1040 DPADPTGNLGHN--ARWDLLAKEAAACTSALCCMGRNGIPIQPW 1081
DPADPTGNLG W LA+EA A + C +G P+ W
Sbjct: 300 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
Score = 295 bits (756), Expect = 1e-79
Identities = 169/369 (45%), Positives = 224/369 (60%), Gaps = 25/369 (6%)
Query: 406 LDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKAS------RVSKG 459
+DL P K LD+FI+D+L P F+ Q+ AIDII L E C +S +V KG
Sbjct: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
Query: 460 GSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLS--L 517
GS G+GT LR D +L++FL+ T ++DQ RR E + E+R QLE+ +++ S+ +
Sbjct: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
Query: 518 QFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLL---TSGC 574
Q P P AL F L S L + +LPAFDA+GQL+ G KPNPQ+Y +L+ T
Sbjct: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
Query: 575 QEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALEL 634
+EGE CF EL+R+F+ RP KLK+LI LVKHWY Q + GK LPP YALEL
Sbjct: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK------LPPQYALEL 234
Query: 635 LTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKP 694
LT++AWE+G + FN AQGFRTVL LV +QQLC+YWT Y ++P + +L QL KP
Sbjct: 235 LTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKP 294
Query: 695 RPLVLDPADPTWNVGHG---SWELLAQEAAALGMQACFLSRDGTSVQPWDVM----PALL 747
RP++LDPADPT N+G G W LAQEA A CF + DG+ V W ++ P +
Sbjct: 295 RPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLTQHTPGSI 354
Query: 748 YQTPAGDLD 756
+ T LD
Sbjct: 355 HPTGRRGLD 363
Score = 283 bits (724), Expect = 6e-76
Identities = 155/345 (44%), Positives = 214/345 (62%), Gaps = 8/345 (2%)
Query: 1 MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG 60
MDL +TPA +LD+F+ L P F + A+ + L+ER R + V K VKG
Sbjct: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
Query: 61 GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF 120
GSSG+GT L+G D++LV+FL ++ DQ RR E + E+R LE+ + ++
Sbjct: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
Query: 121 --PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGC--- 175
P P AL F L+S+ L + ++ ++PAF+ LGQ G KP PQ+Y L+
Sbjct: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
Query: 176 QGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIF 235
+ GE + CFTEL+R+F+ RP KLK+LI LVKHWY Q C + L K LPP YALELLT++
Sbjct: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK--LPPQYALELLTVY 238
Query: 236 AWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVI 295
AWE+G K F+ A+G RTVL L+ +Q LC++WT Y F++P + ++L+RQL +PRPVI
Sbjct: 239 AWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVI 298
Query: 296 LDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSW 340
LDPADPT +LG G W LAQEA + ++PCF G PV SW
Sbjct: 299 LDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
>gi|74229013 2',5'-oligoadenylate synthetase 1 isoform 1 [Homo
sapiens]
Length = 400
Score = 389 bits (999), Expect = e-108
Identities = 206/344 (59%), Positives = 243/344 (70%), Gaps = 13/344 (3%)
Query: 747 LYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNS--PIKVIKVVKGGS 804
L TPA LDKFI ++L P+ F Q+N A+D IC FLKE CFR S P+ V KVVKGGS
Sbjct: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
Query: 805 SAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVS- 863
S KGT LRGRSDADLVVFLS + F +Q N+R E I EIR QLEACQ+ER F VKFEV
Sbjct: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
Query: 864 -KWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNA-- 920
+W NPR LSF L+S L + V+FDVLPAFDALGQL G +P+ Q+YV LI ++
Sbjct: 124 PRWGNPRALSFVLSS-LQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQK 182
Query: 921 -GEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYA 979
GE+STCFTELQRDF+ RPTKLKSLIRLVKHWYQ C K G LPPQ+ LELLTVYA
Sbjct: 183 EGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNC---KKKLGKLPPQYALELLTVYA 239
Query: 980 WEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIIL 1039
WE+G + FN A+GFRTVLELV Y+QLCIYWT Y+ K+ + +L++QL KPRP+IL
Sbjct: 240 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL 299
Query: 1040 DPADPTGNLGHN--ARWDLLAKEAAACTSALCCMGRNGIPIQPW 1081
DPADPTGNLG W LA+EA A + C +G P+ W
Sbjct: 300 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
Score = 295 bits (754), Expect = 2e-79
Identities = 165/349 (47%), Positives = 216/349 (61%), Gaps = 21/349 (6%)
Query: 406 LDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKAS------RVSKG 459
+DL P K LD+FI+D+L P F+ Q+ AIDII L E C +S +V KG
Sbjct: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
Query: 460 GSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLS--L 517
GS G+GT LR D +L++FL+ T ++DQ RR E + E+R QLE+ +++ S+ +
Sbjct: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
Query: 518 QFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLL---TSGC 574
Q P P AL F L S L + +LPAFDA+GQL+ G KPNPQ+Y +L+ T
Sbjct: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
Query: 575 QEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALEL 634
+EGE CF EL+R+F+ RP KLK+LI LVKHWY Q + GK LPP YALEL
Sbjct: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK------LPPQYALEL 234
Query: 635 LTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKP 694
LT++AWE+G + FN AQGFRTVL LV +QQLC+YWT Y ++P + +L QL KP
Sbjct: 235 LTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKP 294
Query: 695 RPLVLDPADPTWNVGHG---SWELLAQEAAALGMQACFLSRDGTSVQPW 740
RP++LDPADPT N+G G W LAQEA A CF + DG+ V W
Sbjct: 295 RPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
Score = 283 bits (724), Expect = 6e-76
Identities = 155/345 (44%), Positives = 214/345 (62%), Gaps = 8/345 (2%)
Query: 1 MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG 60
MDL +TPA +LD+F+ L P F + A+ + L+ER R + V K VKG
Sbjct: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
Query: 61 GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF 120
GSSG+GT L+G D++LV+FL ++ DQ RR E + E+R LE+ + ++
Sbjct: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
Query: 121 --PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGC--- 175
P P AL F L+S+ L + ++ ++PAF+ LGQ G KP PQ+Y L+
Sbjct: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
Query: 176 QGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIF 235
+ GE + CFTEL+R+F+ RP KLK+LI LVKHWY Q C + L K LPP YALELLT++
Sbjct: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK--LPPQYALELLTVY 238
Query: 236 AWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVI 295
AWE+G K F+ A+G RTVL L+ +Q LC++WT Y F++P + ++L+RQL +PRPVI
Sbjct: 239 AWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVI 298
Query: 296 LDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSW 340
LDPADPT +LG G W LAQEA + ++PCF G PV SW
Sbjct: 299 LDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
>gi|74229011 2',5'-oligoadenylate synthetase 1 isoform 2 [Homo
sapiens]
Length = 364
Score = 389 bits (999), Expect = e-108
Identities = 206/344 (59%), Positives = 243/344 (70%), Gaps = 13/344 (3%)
Query: 747 LYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNS--PIKVIKVVKGGS 804
L TPA LDKFI ++L P+ F Q+N A+D IC FLKE CFR S P+ V KVVKGGS
Sbjct: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
Query: 805 SAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVS- 863
S KGT LRGRSDADLVVFLS + F +Q N+R E I EIR QLEACQ+ER F VKFEV
Sbjct: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
Query: 864 -KWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNA-- 920
+W NPR LSF L+S L + V+FDVLPAFDALGQL G +P+ Q+YV LI ++
Sbjct: 124 PRWGNPRALSFVLSS-LQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQK 182
Query: 921 -GEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYA 979
GE+STCFTELQRDF+ RPTKLKSLIRLVKHWYQ C K G LPPQ+ LELLTVYA
Sbjct: 183 EGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNC---KKKLGKLPPQYALELLTVYA 239
Query: 980 WEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIIL 1039
WE+G + FN A+GFRTVLELV Y+QLCIYWT Y+ K+ + +L++QL KPRP+IL
Sbjct: 240 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL 299
Query: 1040 DPADPTGNLGHN--ARWDLLAKEAAACTSALCCMGRNGIPIQPW 1081
DPADPTGNLG W LA+EA A + C +G P+ W
Sbjct: 300 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
Score = 297 bits (760), Expect = 4e-80
Identities = 170/364 (46%), Positives = 222/364 (60%), Gaps = 25/364 (6%)
Query: 406 LDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKAS------RVSKG 459
+DL P K LD+FI+D+L P F+ Q+ AIDII L E C +S +V KG
Sbjct: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
Query: 460 GSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLS--L 517
GS G+GT LR D +L++FL+ T ++DQ RR E + E+R QLE+ +++ S+ +
Sbjct: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
Query: 518 QFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLL---TSGC 574
Q P P AL F L S L + +LPAFDA+GQL+ G KPNPQ+Y +L+ T
Sbjct: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
Query: 575 QEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALEL 634
+EGE CF EL+R+F+ RP KLK+LI LVKHWY Q + GK LPP YALEL
Sbjct: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK------LPPQYALEL 234
Query: 635 LTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKP 694
LT++AWE+G + FN AQGFRTVL LV +QQLC+YWT Y ++P + +L QL KP
Sbjct: 235 LTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKP 294
Query: 695 RPLVLDPADPTWNVGHG---SWELLAQEAAALGMQACFLSRDGTSVQPWDVMPALLYQTP 751
RP++LDPADPT N+G G W LAQEA A CF + DG+ V W LL + P
Sbjct: 295 RPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW----ILLVRPP 350
Query: 752 AGDL 755
A L
Sbjct: 351 ASSL 354
Score = 283 bits (724), Expect = 6e-76
Identities = 155/345 (44%), Positives = 214/345 (62%), Gaps = 8/345 (2%)
Query: 1 MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG 60
MDL +TPA +LD+F+ L P F + A+ + L+ER R + V K VKG
Sbjct: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
Query: 61 GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF 120
GSSG+GT L+G D++LV+FL ++ DQ RR E + E+R LE+ + ++
Sbjct: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
Query: 121 --PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGC--- 175
P P AL F L+S+ L + ++ ++PAF+ LGQ G KP PQ+Y L+
Sbjct: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
Query: 176 QGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIF 235
+ GE + CFTEL+R+F+ RP KLK+LI LVKHWY Q C + L K LPP YALELLT++
Sbjct: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK--LPPQYALELLTVY 238
Query: 236 AWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVI 295
AWE+G K F+ A+G RTVL L+ +Q LC++WT Y F++P + ++L+RQL +PRPVI
Sbjct: 239 AWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVI 298
Query: 296 LDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSW 340
LDPADPT +LG G W LAQEA + ++PCF G PV SW
Sbjct: 299 LDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
>gi|11321577 2'-5'-oligoadenylate synthetase-like isoform a [Homo
sapiens]
Length = 514
Score = 266 bits (680), Expect = 8e-71
Identities = 142/348 (40%), Positives = 207/348 (59%), Gaps = 11/348 (3%)
Query: 747 LYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFR-----NSPIKVIKVVK 801
LY TPA LD F++++LQP+R++ +V AV T+ FL++ F+ + ++V+KVVK
Sbjct: 7 LYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVVK 66
Query: 802 GGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFE 861
GS GT LR + +LV FLSCF F E +++ I + Q + ++ E
Sbjct: 67 VGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTM--WQSQDLLDLGLE 124
Query: 862 VSKWEN--PRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSN 919
+ E P L F++ ++ + + ++PA+ ALG + S+P +VYV LI +
Sbjct: 125 DLRMEQRVPDALVFTIQTRGTAEP-ITVTIVPAYRALGPSLPNSQPPPEVYVSLIKACGG 183
Query: 920 AGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYA 979
G + F+ELQR+F+ RPTKLKSL+RLVKHWYQQ K R +LPP + LELLT+YA
Sbjct: 184 PGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVKARSPRANLPPLYALELLTIYA 243
Query: 980 WEQG-GKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPII 1038
WE G +D F + EGF TV++L+ +Y +CIYWT Y + + D +++QL+K RPII
Sbjct: 244 WEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKKERPII 303
Query: 1039 LDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQPWPVKAA 1086
LDPADPT N+ RWD++A+ A+ C CC PI W VK A
Sbjct: 304 LDPADPTLNVAEGYRWDIVAQRASQCLKQDCCYDNRENPISSWNVKRA 351
Score = 239 bits (611), Expect = 8e-63
Identities = 137/346 (39%), Positives = 201/346 (58%), Gaps = 12/346 (3%)
Query: 2 DLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRE---RGGRLGAAAPRVLKTV 58
+LYSTPA+ LD FVA+ LQP +E+ E+ A+ + LR+ +G R RVLK V
Sbjct: 6 ELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVV 65
Query: 59 KGGSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVP---G 115
K GS G GT L+ + ELV FL CF S+ + ++L R ++ WQ+ G
Sbjct: 66 KVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVL---RLIWKTMWQSQDLLDLG 122
Query: 116 LRLTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGC 175
L EQ VP AL F + + + + V++VPA+ LG + +P P+VY +L+ +
Sbjct: 123 LEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKACG 182
Query: 176 QGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIF 235
G F+EL+RNFV RP KLK+L+ LVKHWY Q + LPP+YALELLTI+
Sbjct: 183 GPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVKARSPRANLPPLYALELLTIY 242
Query: 236 AWEQGCKKDA-FSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPV 294
AWE G ++D F L EG TV+ L+ +++ +C++WT Y + + +++QLK+ RP+
Sbjct: 243 AWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKKERPI 302
Query: 295 ILDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSW 340
ILDPADPT ++ G + WD++AQ A+ C C +P+ SW
Sbjct: 303 ILDPADPTLNVAEG--YRWDIVAQRASQCLKQDCCYDNRENPISSW 346
Score = 211 bits (537), Expect = 3e-54
Identities = 126/353 (35%), Positives = 195/353 (55%), Gaps = 21/353 (5%)
Query: 407 DLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVH---------KASRVS 457
+L P LD F+ L+P +++E+V A+ + L + + +V
Sbjct: 6 ELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVV 65
Query: 458 KGGSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQ-VPSLS 516
K GSFG GT LR +VEL+ FL+CF +++ ++L R ++ WQ Q + L
Sbjct: 66 KVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVL---RLIWKTMWQSQDLLDLG 122
Query: 517 LQF--PEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGC 574
L+ EQ VP+AL F + + V+++PA+ A+G ++P P+VY L+ +
Sbjct: 123 LEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKACG 182
Query: 575 QEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALEL 634
G F+EL+RNF+ RP KLK+L+ LVKHWY+Q K + P A+LPP YALEL
Sbjct: 183 GPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYV---KARSPR-ANLPPLYALEL 238
Query: 635 LTIFAWEQGCRQD-CFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRK 693
LTI+AWE G +D F + +GF TV+ L+ +++ +C+YWT Y+ + + + QL+K
Sbjct: 239 LTIYAWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKK 298
Query: 694 PRPLVLDPADPTWNVGHG-SWELLAQEAAALGMQACFLSRDGTSVQPWDVMPA 745
RP++LDPADPT NV G W+++AQ A+ Q C + W+V A
Sbjct: 299 ERPIILDPADPTLNVAEGYRWDIVAQRASQCLKQDCCYDNRENPISSWNVKRA 351
>gi|38016930 2'-5'-oligoadenylate synthetase-like isoform b [Homo
sapiens]
Length = 255
Score = 147 bits (370), Expect = 7e-35
Identities = 87/232 (37%), Positives = 131/232 (56%), Gaps = 12/232 (5%)
Query: 747 LYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFR-----NSPIKVIKVVK 801
LY TPA LD F++++LQP+R++ +V AV T+ FL++ F+ + ++V+KVVK
Sbjct: 7 LYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVVK 66
Query: 802 GGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFE 861
GS GT LR + +LV FLSCF F E +++ I + Q + ++ E
Sbjct: 67 VGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTM--WQSQDLLDLGLE 124
Query: 862 VSKWEN--PRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSN 919
+ E P L F++ ++ + + ++PA+ ALG + S+P +VYV LI +
Sbjct: 125 DLRMEQRVPDALVFTIQTRGTAEP-ITVTIVPAYRALGPSLPNSQPPPEVYVSLIKACGG 183
Query: 920 AGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHG 971
G + F+ELQR+F+ RPTKLKSL+RLVKHWYQQ GR PQ G
Sbjct: 184 PGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQAHHPGSGRPH--PQRG 233
Score = 135 bits (339), Expect = 3e-31
Identities = 86/217 (39%), Positives = 122/217 (56%), Gaps = 9/217 (4%)
Query: 2 DLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRE---RGGRLGAAAPRVLKTV 58
+LYSTPA+ LD FVA+ LQP +E+ E+ A+ + LR+ +G R RVLK V
Sbjct: 6 ELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVV 65
Query: 59 KGGSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVP---G 115
K GS G GT L+ + ELV FL CF S+ + ++L R ++ WQ+ G
Sbjct: 66 KVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVL---RLIWKTMWQSQDLLDLG 122
Query: 116 LRLTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGC 175
L EQ VP AL F + + + + V++VPA+ LG + +P P+VY +L+ +
Sbjct: 123 LEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKACG 182
Query: 176 QGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQ 212
G F+EL+RNFV RP KLK+L+ LVKHWY Q
Sbjct: 183 GPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQ 219
Score = 116 bits (291), Expect = 1e-25
Identities = 73/225 (32%), Positives = 117/225 (52%), Gaps = 15/225 (6%)
Query: 407 DLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVH---------KASRVS 457
+L P LD F+ L+P +++E+V A+ + L + + +V
Sbjct: 6 ELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVV 65
Query: 458 KGGSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQ-VPSLS 516
K GSFG GT LR +VEL+ FL+CF +++ ++L R ++ WQ Q + L
Sbjct: 66 KVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVL---RLIWKTMWQSQDLLDLG 122
Query: 517 LQF--PEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGC 574
L+ EQ VP+AL F + + V+++PA+ A+G ++P P+VY L+ +
Sbjct: 123 LEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKACG 182
Query: 575 QEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGK 619
G F+EL+RNF+ RP KLK+L+ LVKHWY+Q G+
Sbjct: 183 GPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQAHHPGSGR 227
>gi|74229021 2'-5'-oligoadenylate synthetase 2 isoform 3 [Homo
sapiens]
Length = 172
Score = 70.9 bits (172), Expect = 6e-12
Identities = 53/160 (33%), Positives = 83/160 (51%), Gaps = 10/160 (6%)
Query: 747 LYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNSPIKVIKVVKGGSSA 806
L PA L FI E+L+P + +++ V+TIC L+E P+ V V GGS
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEP--EQFPL-VQGVAIGGSYG 64
Query: 807 KGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVSKWE 866
+ T LRG SD LV+F S QF +Q + +I+ + +L+ C + + FE+ K
Sbjct: 65 RKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEIQK-- 122
Query: 867 NPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQ--LVSGSR 904
+ F++ T +Q + F+VL AF+AL + VSG +
Sbjct: 123 --SLDGFTIQVFTK-NQRISFEVLAAFNALSKHCWVSGEK 159
Score = 53.5 bits (127), Expect = 1e-06
Identities = 32/99 (32%), Positives = 54/99 (54%), Gaps = 1/99 (1%)
Query: 408 LSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHE-NCVHKASRVSKGGSFGRGT 466
LS +P ++L FIQ++LKP + Q + + ++ I L E V+ GGS+GR T
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIGGSYGRKT 67
Query: 467 DLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLE 505
LR D L++F + ++DQ + +ILD+ +L+
Sbjct: 68 VLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLK 106
Score = 43.9 bits (102), Expect = 8e-04
Identities = 30/98 (30%), Positives = 43/98 (43%), Gaps = 5/98 (5%)
Query: 3 LYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKGGS 62
L S PA L F+ L+P +E + + L+E P V GGS
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEP-----EQFPLVQGVAIGGS 62
Query: 63 SGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSE 100
GR T L+G D LV+F K + DQ+ + +IL +
Sbjct: 63 YGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDK 100
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 36.6 bits (83), Expect = 0.13
Identities = 32/120 (26%), Positives = 46/120 (38%), Gaps = 5/120 (4%)
Query: 346 PRAGCSGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPS---CPAPGPTGAASIVPSVP 402
P GC G GH L P+ ++ + + P + + CP PG TG V S
Sbjct: 443 PTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGH-VNSNR 501
Query: 403 GMALDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSF 462
LS P ++ + H K PQ + K + + R L C K V GS+
Sbjct: 502 NTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSD-RILRPMCFVKQLEVPPYGSY 560
>gi|21071060 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a-like 1 [Homo sapiens]
Length = 954
Score = 35.8 bits (81), Expect = 0.23
Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 14/112 (12%)
Query: 334 GDPVQSWKGPG--LPRAGCSGLGHPIQLDPNQ--------KTPENSKSLNA--VYPRAGS 381
G+P Q+ +GP PR C + H + + P +S S A ++ +
Sbjct: 44 GNPFQAKQGPSQNFPRESCKPVSHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEE 103
Query: 382 KPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI--QDHLKPSPQFQ 431
P +CP P ++ P +A ++P ++L + Q H + SP+ +
Sbjct: 104 MPTACPGHSPRSQMALTGISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIR 155
>gi|187761314 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a-like 1 [Homo sapiens]
Length = 954
Score = 35.8 bits (81), Expect = 0.23
Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 14/112 (12%)
Query: 334 GDPVQSWKGPG--LPRAGCSGLGHPIQLDPNQ--------KTPENSKSLNA--VYPRAGS 381
G+P Q+ +GP PR C + H + + P +S S A ++ +
Sbjct: 44 GNPFQAKQGPSQNFPRESCKPVSHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEE 103
Query: 382 KPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI--QDHLKPSPQFQ 431
P +CP P ++ P +A ++P ++L + Q H + SP+ +
Sbjct: 104 MPTACPGHSPRSQMALTGISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIR 155
>gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens]
Length = 1729
Score = 35.4 bits (80), Expect = 0.30
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 343 PGLP-RAGCSGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVP 399
PGLP A SG G P P++ +P +S+ L A P A P CPA P+ ++ +P
Sbjct: 288 PGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASP-CPAVTPSAPSAALP 344
>gi|197116386 5'-nucleotidase domain containing 2 isoform 1 [Homo
sapiens]
Length = 557
Score = 35.4 bits (80), Expect = 0.30
Identities = 19/41 (46%), Positives = 21/41 (51%), Gaps = 2/41 (4%)
Query: 377 PRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELD 417
PRA S PSCP GP G + P VP A +Q PT D
Sbjct: 22 PRAASSSPSCPGCGPPGPGAHCPGVPRSA--PAQAPTSGAD 60
>gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]
Length = 1499
Score = 34.7 bits (78), Expect = 0.50
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 12/76 (15%)
Query: 330 LRGMGDPVQSWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVYPRAG---SKPPSC 386
L+G D + ++ +PRA +LD K P + L P AG S+PP
Sbjct: 256 LQGRADSILAYHQQNVPRA---------KLDQAPKVPPTPEPLPLSTPSAGTPQSQPPPL 306
Query: 387 PAPGPTGAASIVPSVP 402
P P P S P++P
Sbjct: 307 PPPPPPAPGSAPPALP 322
>gi|208022661 hypothetical protein LOC57701 [Homo sapiens]
Length = 1334
Score = 34.3 bits (77), Expect = 0.66
Identities = 29/90 (32%), Positives = 35/90 (38%), Gaps = 8/90 (8%)
Query: 322 SCYDHPCFLRGMGDPVQ---SWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVYPR 378
+C D PC G PVQ +W P AG S P+ P Q + R
Sbjct: 1213 TCPDDPCEDPGPTPPVQLAKNWTFPNTRAAGSS--SDPLMCPPRQLEGLPRTPMALPVDR 1270
Query: 379 AGSKPPSCPAPGPTG---AASIVPSVPGMA 405
S+ PS P+P P G S PS MA
Sbjct: 1271 KRSQEPSRPSPTPQGPPFGGSRTPSTSDMA 1300
>gi|116734702 homeobox D13 [Homo sapiens]
Length = 343
Score = 32.7 bits (73), Expect = 1.9
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 6/60 (10%)
Query: 348 AGCSGLGHPIQLDPNQKT-PENSKSLNAVYPRAGSKPPS--CPAPGPTGAASIVPSVPGM 404
A SG +P +++T +S S +AV PP+ CPAP P AA+ PS P +
Sbjct: 69 AAASGFAYP---GTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPPSAPAL 125
>gi|169215453 PREDICTED: hypothetical protein [Homo sapiens]
Length = 707
Score = 31.6 bits (70), Expect = 4.3
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 375 VYPRAGSKPPSCPAPGPTGAASIVPSV 401
V P A S PP+CPAP G+ S P+V
Sbjct: 543 VQPPAVSSPPACPAPATQGSRSQQPTV 569
>gi|169215350 PREDICTED: hypothetical protein [Homo sapiens]
Length = 707
Score = 31.6 bits (70), Expect = 4.3
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 375 VYPRAGSKPPSCPAPGPTGAASIVPSV 401
V P A S PP+CPAP G+ S P+V
Sbjct: 543 VQPPAVSSPPACPAPATQGSRSQQPTV 569
>gi|239756829 PREDICTED: zinc finger protein 385C [Homo sapiens]
Length = 1082
Score = 31.2 bits (69), Expect = 5.6
Identities = 30/90 (33%), Positives = 37/90 (41%), Gaps = 8/90 (8%)
Query: 317 AQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVY 376
AQ+ A P G QS K P P G L P DP + P +S+ L+A
Sbjct: 781 AQDGAVVSPIPTLASGAPGEPQS-KVPAAPPLG-PPLQPPPTPDPTCREPAHSELLDAAS 838
Query: 377 PRAGSKPPSC------PAPGPTGAASIVPS 400
+ S P C APGP AA+ V S
Sbjct: 839 SSSSSSCPPCSPEPGREAPGPEPAAAAVGS 868
>gi|239751322 PREDICTED: zinc finger protein 385C [Homo sapiens]
Length = 1082
Score = 31.2 bits (69), Expect = 5.6
Identities = 30/90 (33%), Positives = 37/90 (41%), Gaps = 8/90 (8%)
Query: 317 AQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVY 376
AQ+ A P G QS K P P G L P DP + P +S+ L+A
Sbjct: 781 AQDGAVVSPIPTLASGAPGEPQS-KVPAAPPLG-PPLQPPPTPDPTCREPAHSELLDAAS 838
Query: 377 PRAGSKPPSC------PAPGPTGAASIVPS 400
+ S P C APGP AA+ V S
Sbjct: 839 SSSSSSCPPCSPEPGREAPGPEPAAAAVGS 868
>gi|239745821 PREDICTED: zinc finger protein 385C [Homo sapiens]
Length = 1082
Score = 31.2 bits (69), Expect = 5.6
Identities = 30/90 (33%), Positives = 37/90 (41%), Gaps = 8/90 (8%)
Query: 317 AQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVY 376
AQ+ A P G QS K P P G L P DP + P +S+ L+A
Sbjct: 781 AQDGAVVSPIPTLASGAPGEPQS-KVPAAPPLG-PPLQPPPTPDPTCREPAHSELLDAAS 838
Query: 377 PRAGSKPPSC------PAPGPTGAASIVPS 400
+ S P C APGP AA+ V S
Sbjct: 839 SSSSSSCPPCSPEPGREAPGPEPAAAAVGS 868
>gi|126116581 retina and anterior neural fold homeobox [Homo
sapiens]
Length = 346
Score = 31.2 bits (69), Expect = 5.6
Identities = 24/69 (34%), Positives = 27/69 (39%), Gaps = 14/69 (20%)
Query: 336 PVQSWKGPGLPRAGCS------GLGHPIQLDPNQKTPE-------NSKSLNAVYPRAGSK 382
P++SW GP LP G + G G P Q P TP NS L
Sbjct: 240 PLESWLGPPLPGGGATALQSLPGFGPPAQSLPASYTPPPPPPPFLNSPPLGPGLQPLAPP 299
Query: 383 PPSCP-APG 390
PPS P PG
Sbjct: 300 PPSYPCGPG 308
>gi|145977194 hypothetical protein LOC400793 isoform 2 [Homo
sapiens]
Length = 272
Score = 31.2 bits (69), Expect = 5.6
Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 494 AEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVG 553
A++ A E+W +D+ L FP + P + + ALK+ D+ L+ + +
Sbjct: 88 AQLASGTDAAPEAWLEDERSVLQETFPRLDPPPPITRKRTPRALKTTQDM-LISSQPVLS 146
Query: 554 QLSSGTKPNP 563
L GT+P+P
Sbjct: 147 SLEYGTEPSP 156
>gi|207028635 hypothetical protein LOC400793 isoform 1 [Homo
sapiens]
Length = 315
Score = 31.2 bits (69), Expect = 5.6
Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 494 AEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVG 553
A++ A E+W +D+ L FP + P + + ALK+ D+ L+ + +
Sbjct: 131 AQLASGTDAAPEAWLEDERSVLQETFPRLDPPPPITRKRTPRALKTTQDM-LISSQPVLS 189
Query: 554 QLSSGTKPNP 563
L GT+P+P
Sbjct: 190 SLEYGTEPSP 199
>gi|42544243 dynamin 3 isoform a [Homo sapiens]
Length = 863
Score = 31.2 bits (69), Expect = 5.6
Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 3/64 (4%)
Query: 343 PGLPRAGCSGLGHPIQLDPNQKTPENSKSLNA--VYPRAGSKP-PSCPAPGPTGAASIVP 399
P P S + H + P T + +L+A P +G P P+ P+PGP A VP
Sbjct: 747 PAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTSGRGPAPAIPSPGPHSGAPPVP 806
Query: 400 SVPG 403
PG
Sbjct: 807 FRPG 810
>gi|209915561 dynamin 3 isoform b [Homo sapiens]
Length = 859
Score = 31.2 bits (69), Expect = 5.6
Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 3/64 (4%)
Query: 343 PGLPRAGCSGLGHPIQLDPNQKTPENSKSLNA--VYPRAGSKP-PSCPAPGPTGAASIVP 399
P P S + H + P T + +L+A P +G P P+ P+PGP A VP
Sbjct: 743 PAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTSGRGPAPAIPSPGPHSGAPPVP 802
Query: 400 SVPG 403
PG
Sbjct: 803 FRPG 806
>gi|195963410 MEF2 activating motif and SAP domain containing
transcriptional regulator isoform 1 [Homo sapiens]
Length = 415
Score = 30.8 bits (68), Expect = 7.3
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 17/67 (25%)
Query: 377 PRAGSKPPSCPAPGPTGAASIVPSV-----PG-MALDLSQ-----------IPTKELDRF 419
PRA P + PAP PT A + P++ PG AL L + +P + +D
Sbjct: 254 PRAADTPGTAPAPTPTPAPAAAPALTPSSGPGSAALTLEEELQEAIRRAQLLPNRGIDDI 313
Query: 420 IQDHLKP 426
++D ++P
Sbjct: 314 LEDQVEP 320
>gi|32698970 MEF2 activating motif and SAP domain containing
transcriptional regulator isoform 2 [Homo sapiens]
Length = 312
Score = 30.8 bits (68), Expect = 7.3
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 17/67 (25%)
Query: 377 PRAGSKPPSCPAPGPTGAASIVPSV-----PG-MALDLSQ-----------IPTKELDRF 419
PRA P + PAP PT A + P++ PG AL L + +P + +D
Sbjct: 151 PRAADTPGTAPAPTPTPAPAAAPALTPSSGPGSAALTLEEELQEAIRRAQLLPNRGIDDI 210
Query: 420 IQDHLKP 426
++D ++P
Sbjct: 211 LEDQVEP 217
>gi|50233787 nuclear protein in testis [Homo sapiens]
Length = 1132
Score = 30.8 bits (68), Expect = 7.3
Identities = 20/60 (33%), Positives = 24/60 (40%), Gaps = 4/60 (6%)
Query: 343 PGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVP 402
PG P G G P N KT SK++ + PP P P A +VP VP
Sbjct: 119 PGTPCGGLEGPAPPFVTASNVKTILPSKAVGV----SQEGPPGLPPQPPPPVAQLVPIVP 174
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,363,281
Number of Sequences: 37866
Number of extensions: 2216372
Number of successful extensions: 7190
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 6984
Number of HSP's gapped (non-prelim): 93
length of query: 1087
length of database: 18,247,518
effective HSP length: 113
effective length of query: 974
effective length of database: 13,968,660
effective search space: 13605474840
effective search space used: 13605474840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.