Guide to the Human Genome
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Search of human proteins with 42740901

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]
         (775 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]          1571   0.0  
gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]          1571   0.0  
gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]          1571   0.0  
gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]          1459   0.0  
gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isofo...  1303   0.0  
gi|56847634 hypothetical protein LOC441294 [Homo sapiens]            1248   0.0  
gi|224586773 hypothetical protein LOC643854 [Homo sapiens]           1246   0.0  
gi|146262005 CTAGE family, member 6 [Homo sapiens]                   1244   0.0  
gi|193290160 CTAGE family, member 4 [Homo sapiens]                   1241   0.0  
gi|122891870 melanoma inhibitory activity family, member 3 [Homo...   265   9e-71
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       99   2e-20
gi|118498368 kinectin 1 isoform c [Homo sapiens]                       99   2e-20
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        99   2e-20
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    85   2e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    85   2e-16
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       84   4e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    82   2e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    81   4e-15
gi|55770834 centromere protein F [Homo sapiens]                        81   4e-15
gi|34878904 synaptonemal complex protein 1 [Homo sapiens]              80   6e-15
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    80   6e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    80   9e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    80   9e-15
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    80   9e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     79   1e-14
gi|32698688 citron [Homo sapiens]                                      79   1e-14
gi|148746195 trichohyalin [Homo sapiens]                               79   2e-14
gi|42794779 myosin 18A isoform b [Homo sapiens]                        79   2e-14
gi|28416946 myosin 18A isoform a [Homo sapiens]                        79   2e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             78   3e-14

>gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]
          Length = 804

 Score = 1571 bits (4069), Expect = 0.0
 Identities = 775/775 (100%), Positives = 775/775 (100%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK
Sbjct: 30  MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 89

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 120
           SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE
Sbjct: 90  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 149

Query: 121 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 180
           KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK
Sbjct: 150 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 209

Query: 181 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 240
           DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE
Sbjct: 210 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 269

Query: 241 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 300
           RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL
Sbjct: 270 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 329

Query: 301 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 360
           EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY
Sbjct: 330 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 389

Query: 361 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 420
           QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY
Sbjct: 390 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 449

Query: 421 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 480
           QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN
Sbjct: 450 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 509

Query: 481 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 540
           TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ
Sbjct: 510 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 569

Query: 541 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 600
           ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS
Sbjct: 570 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 629

Query: 601 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 660
           NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP
Sbjct: 630 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 689

Query: 661 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 720
           GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA
Sbjct: 690 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 749

Query: 721 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 775
           MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET
Sbjct: 750 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 804


>gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]
          Length = 775

 Score = 1571 bits (4069), Expect = 0.0
 Identities = 775/775 (100%), Positives = 775/775 (100%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK
Sbjct: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 120
           SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE
Sbjct: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 120

Query: 121 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 180
           KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK
Sbjct: 121 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 180

Query: 181 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 240
           DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE
Sbjct: 181 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 240

Query: 241 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 300
           RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL
Sbjct: 241 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 300

Query: 301 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 360
           EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY
Sbjct: 301 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 360

Query: 361 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 420
           QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY
Sbjct: 361 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 420

Query: 421 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 480
           QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN
Sbjct: 421 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 480

Query: 481 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 540
           TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ
Sbjct: 481 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 540

Query: 541 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 600
           ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS
Sbjct: 541 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 600

Query: 601 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 660
           NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP
Sbjct: 601 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 660

Query: 661 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 720
           GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA
Sbjct: 661 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 720

Query: 721 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 775
           MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET
Sbjct: 721 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 775


>gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]
          Length = 792

 Score = 1571 bits (4069), Expect = 0.0
 Identities = 775/775 (100%), Positives = 775/775 (100%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK
Sbjct: 18  MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 77

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 120
           SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE
Sbjct: 78  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 137

Query: 121 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 180
           KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK
Sbjct: 138 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 197

Query: 181 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 240
           DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE
Sbjct: 198 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 257

Query: 241 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 300
           RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL
Sbjct: 258 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 317

Query: 301 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 360
           EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY
Sbjct: 318 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 377

Query: 361 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 420
           QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY
Sbjct: 378 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 437

Query: 421 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 480
           QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN
Sbjct: 438 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 497

Query: 481 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 540
           TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ
Sbjct: 498 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 557

Query: 541 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 600
           ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS
Sbjct: 558 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 617

Query: 601 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 660
           NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP
Sbjct: 618 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 677

Query: 661 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 720
           GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA
Sbjct: 678 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 737

Query: 721 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 775
           MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET
Sbjct: 738 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 792


>gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]
          Length = 761

 Score = 1459 bits (3778), Expect = 0.0
 Identities = 732/775 (94%), Positives = 732/775 (94%), Gaps = 43/775 (5%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK
Sbjct: 30  MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 89

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 120
           SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE
Sbjct: 90  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 149

Query: 121 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 180
           KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK
Sbjct: 150 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 209

Query: 181 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 240
           DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE
Sbjct: 210 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 269

Query: 241 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 300
           RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL
Sbjct: 270 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 329

Query: 301 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 360
           EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY
Sbjct: 330 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 389

Query: 361 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 420
           QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY
Sbjct: 390 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 449

Query: 421 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 480
           QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN
Sbjct: 450 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 509

Query: 481 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 540
           TAFG                                           RGSRGPGNPLDHQ
Sbjct: 510 TAFG-------------------------------------------RGSRGPGNPLDHQ 526

Query: 541 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 600
           ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS
Sbjct: 527 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 586

Query: 601 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 660
           NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP
Sbjct: 587 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 646

Query: 661 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 720
           GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA
Sbjct: 647 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 706

Query: 721 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 775
           MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET
Sbjct: 707 MRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET 761


>gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isoform
           1 [Homo sapiens]
          Length = 745

 Score = 1303 bits (3373), Expect = 0.0
 Identities = 660/745 (88%), Positives = 682/745 (91%), Gaps = 2/745 (0%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPDS+ YGFPWELVI AAV GFFAVLF LWRSFRSV SRLYV REKK A+ LSGLIEEK
Sbjct: 1   MRPDSHPYGFPWELVIRAAVAGFFAVLF-LWRSFRSVTSRLYVRREKKFAVALSGLIEEK 59

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLE 120
            KLLEKFSLVQKEYEGYEVESSLK+ASFEKEATEAQSLEATCEKLNR NSEL  EILCLE
Sbjct: 60  CKLLEKFSLVQKEYEGYEVESSLKNASFEKEATEAQSLEATCEKLNRFNSELVHEILCLE 119

Query: 121 KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIK 180
           KELKEEKSKHSEQ+ELMADISKRIQSLEDESKSLKSQVAEAKMTFK FQ NEERL+I I+
Sbjct: 120 KELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEAKMTFKRFQANEERLEIEIQ 179

Query: 181 DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE 240
           DA  ENS+LQESQKQLLQEAEVWKEQVSEL KQK TFEDSKVHAEQVLNDKE+HIKTLTE
Sbjct: 180 DAWKENSELQESQKQLLQEAEVWKEQVSELIKQKRTFEDSKVHAEQVLNDKENHIKTLTE 239

Query: 241 RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL 300
           RLLKMKD  AML ED+TDDDNLELEMNSESE+GAYLDNPPKGALKKLIHAAKLNASLKTL
Sbjct: 240 RLLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLDNPPKGALKKLIHAAKLNASLKTL 299

Query: 301 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELY 360
           EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFE+ENQKLQQKLKVMTELY
Sbjct: 300 EGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFESENQKLQQKLKVMTELY 359

Query: 361 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 420
           QENEMKL+RKL VEE  RLEKEEKLSKVDE ISHATEELETYRKRAKDL +E E+TIH Y
Sbjct: 360 QENEMKLYRKLIVEEKCRLEKEEKLSKVDEMISHATEELETYRKRAKDL-KEFEKTIHFY 418

Query: 421 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 480
           Q +II HEKKAHDNW AA  AERNLNDLRKENAHNRQKLTE E K +LLEKDPY LDVPN
Sbjct: 419 QKKIILHEKKAHDNWSAAWTAERNLNDLRKENAHNRQKLTEIEFKIKLLEKDPYGLDVPN 478

Query: 481 TAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQ 540
           TAFGR+HSPYGPSPLGWPSSETRA L PPTLLEGPLRLSPLLP GGGRGSRGPGNP DHQ
Sbjct: 479 TAFGRQHSPYGPSPLGWPSSETRASLYPPTLLEGPLRLSPLLPRGGGRGSRGPGNPPDHQ 538

Query: 541 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 600
           IT ERGESSCDRLTDPHRAPSD G L+PPW+QD RMMFPPPGQSYPDSALPPQRQDRF S
Sbjct: 539 ITKERGESSCDRLTDPHRAPSDAGPLAPPWEQDYRMMFPPPGQSYPDSALPPQRQDRFYS 598

Query: 601 NSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGP 660
           N  RLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKD+LGNL VPDSSLPAENEATGP
Sbjct: 599 NCARLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDNLGNLKVPDSSLPAENEATGP 658

Query: 661 GFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFA 720
           GFVPPPLAPIRG LFPVD RGPF+RRGPPFPPPPPG +FGAS DYF P D PGPP APFA
Sbjct: 659 GFVPPPLAPIRGLLFPVDTRGPFIRRGPPFPPPPPGTVFGASPDYFSPRDVPGPPRAPFA 718

Query: 721 MRNVYPPRGFPPYLPPRPGFFPPPP 745
           MRNVY PRGF PY PPRP FFPP P
Sbjct: 719 MRNVYLPRGFLPYRPPRPAFFPPAP 743


>gi|56847634 hypothetical protein LOC441294 [Homo sapiens]
          Length = 777

 Score = 1248 bits (3230), Expect = 0.0
 Identities = 625/746 (83%), Positives = 672/746 (90%), Gaps = 2/746 (0%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL   LSGLIEEK
Sbjct: 30  MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSELEDEILCL 119
            KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKLNRSNSELEDEILCL
Sbjct: 90  CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCL 149

Query: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
           EK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+  K F+M+EER  IAI
Sbjct: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209

Query: 180 KDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTL 238
           KDALNENSQLQ S KQL Q EAEVWK QVSELNKQK+TFEDSKVHAEQVLNDKE+HIKTL
Sbjct: 210 KDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269

Query: 239 TERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLK 298
           T  L  MKD AA+L ED TDDDNLELE+NS+ ENGA LD+P KGALKKLIHAAKLN SLK
Sbjct: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329

Query: 299 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTE 358
           +LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FE+ENQKLQQKLK+MTE
Sbjct: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389

Query: 359 LYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIH 418
            YQENEMKL+RKLTVEENYR+E+EEKLS+V+EK+S ATE+LETYRK AKDLEEELERT+H
Sbjct: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVH 449

Query: 419 SYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDV 478
            YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTETELKFELLEKDP ALDV
Sbjct: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV 509

Query: 479 PNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLD 538
            NTAFGREH+P GP+PLG  SSETRAFLSP TLLE PL LSP+LP GGGRG RGPGNPLD
Sbjct: 510 SNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLGLSPVLPEGGGRGPRGPGNPLD 569

Query: 539 HQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRF 598
           HQITNERGE SCDRLTDPHRAPSDTGSLS P +QD +MMFPPPGQSYPDSALPPQR+DRF
Sbjct: 570 HQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQREDRF 629

Query: 599 CSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEAT 658
            SNS RLSG AE RSF M SLDKMDGSMPSEMESSRND KDDLGNLNVPDSSLPAENEAT
Sbjct: 630 YSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689

Query: 659 GPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAP 718
           GPGF+PPPLAP+RGPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP DFPGPP AP
Sbjct: 690 GPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749

Query: 719 FAMRNVYPPRGFPPYLPPRPGFFPPP 744
           FAMRN+YPPRG PPY  PRPGF+P P
Sbjct: 750 FAMRNIYPPRGLPPYFHPRPGFYPNP 775


>gi|224586773 hypothetical protein LOC643854 [Homo sapiens]
          Length = 777

 Score = 1246 bits (3225), Expect = 0.0
 Identities = 626/746 (83%), Positives = 669/746 (89%), Gaps = 2/746 (0%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL   LSGLIEEK
Sbjct: 30  MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSELEDEILCL 119
            KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKL+RSNSELEDEILCL
Sbjct: 90  CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLSRSNSELEDEILCL 149

Query: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
           EK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+  K F+M+EER  IAI
Sbjct: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209

Query: 180 KDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTL 238
           KDALNENSQLQ S KQL Q EAEVWK QVSELNKQK+TFEDSKVHAEQVLNDKE+HIKTL
Sbjct: 210 KDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269

Query: 239 TERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLK 298
           T  L  MKD AA+L ED TDDDNLEL++NS+ ENGA LD+PPKGALKKLIHAAKLN SLK
Sbjct: 270 TGHLPMMKDQAAVLEEDTTDDDNLELKVNSQWENGANLDDPPKGALKKLIHAAKLNVSLK 329

Query: 299 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTE 358
           +LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FE+ENQKLQQKLK+MTE
Sbjct: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389

Query: 359 LYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIH 418
            YQENEMKL+RKLTVEENYR+E+EEKLS+V+EKISHATEELETYRK AKDLEEELERT+H
Sbjct: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISHATEELETYRKLAKDLEEELERTVH 449

Query: 419 SYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDV 478
            YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTE ELKFELLEKDP ALDV
Sbjct: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTERELKFELLEKDPNALDV 509

Query: 479 PNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLD 538
            NTAFGREHSP  PSPLG PSSETRAF SP TLLE PLRLSP+LPGGGGRG   PGNPLD
Sbjct: 510 SNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLD 569

Query: 539 HQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRF 598
           HQITNERGE S DRL DPHRAPSDTGSLS P +QDRRMMFPPPGQSYPDS LPPQR+DRF
Sbjct: 570 HQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRF 629

Query: 599 CSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEAT 658
            SNS RLSGPAE RSF M SLDKMD SMPSEMESSRND KDDLGNLNVPDSSLPAENEAT
Sbjct: 630 YSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689

Query: 659 GPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAP 718
           GPG +PPPLAPI GPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP DFPGPP AP
Sbjct: 690 GPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749

Query: 719 FAMRNVYPPRGFPPYLPPRPGFFPPP 744
           FAMRN+YPPRG PPYL PRPGF+P P
Sbjct: 750 FAMRNIYPPRGLPPYLHPRPGFYPNP 775


>gi|146262005 CTAGE family, member 6 [Homo sapiens]
          Length = 777

 Score = 1244 bits (3220), Expect = 0.0
 Identities = 623/746 (83%), Positives = 671/746 (89%), Gaps = 2/746 (0%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL   LSGLIEEK
Sbjct: 30  MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSELEDEILCL 119
            KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKLNRSNSELEDEILCL
Sbjct: 90  CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCL 149

Query: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
           EK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+  K F+M+EER  IAI
Sbjct: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209

Query: 180 KDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTL 238
           KDALNENSQLQ S KQL Q EAEVWK +VSELNKQK+TFEDSKVHAEQVLNDKE+HIKTL
Sbjct: 210 KDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269

Query: 239 TERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLK 298
           T  L  MKD AA+L ED TDDDNLELE+NS+ ENGA LD+P KGALKKLIHAAKLN SLK
Sbjct: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329

Query: 299 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTE 358
           +LEGERN I IQLSEVDKTKEELTEHIKNLQT+Q SLQSEN +FE+ENQKLQQKLK+MTE
Sbjct: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQESLQSENIYFESENQKLQQKLKIMTE 389

Query: 359 LYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIH 418
            YQE+EMKL+RKLTVEENYR+E+EEKLSKV+EK+S ATE+LETYRK AKDLEEELERT+H
Sbjct: 390 FYQEDEMKLYRKLTVEENYRIEEEEKLSKVEEKLSRATEQLETYRKLAKDLEEELERTVH 449

Query: 419 SYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDV 478
            YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTETELKFELLEKDP ALDV
Sbjct: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV 509

Query: 479 PNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLD 538
            NTAFGREH+P GP+PLG  SSETRAFLSP TLLE PL LSP+LP GGGRG RGPGNPLD
Sbjct: 510 SNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLGLSPVLPEGGGRGPRGPGNPLD 569

Query: 539 HQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRF 598
           HQITNERGE SCDRLTDPHRAPSDTGSLS P +QD +MMFPPPGQSYPDSALPPQR+DRF
Sbjct: 570 HQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQREDRF 629

Query: 599 CSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEAT 658
            SNS RLSG AE RSF M SLDKMDGSMPSEMESSRND KDDLGNLNVPDSSLPAENEAT
Sbjct: 630 YSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689

Query: 659 GPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAP 718
           GPGF+PPPLAP+RGPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP DFPGPP AP
Sbjct: 690 GPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749

Query: 719 FAMRNVYPPRGFPPYLPPRPGFFPPP 744
           FAMRN+YPPRG PPY  PRPGF+P P
Sbjct: 750 FAMRNIYPPRGLPPYFHPRPGFYPNP 775


>gi|193290160 CTAGE family, member 4 [Homo sapiens]
          Length = 777

 Score = 1241 bits (3212), Expect = 0.0
 Identities = 625/746 (83%), Positives = 667/746 (89%), Gaps = 2/746 (0%)

Query: 1   MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
           MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL   LSGLIEEK
Sbjct: 30  MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89

Query: 61  SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSELEDEILCL 119
            KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKLNRSNSELEDEILCL
Sbjct: 90  CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCL 149

Query: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
           EK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+  K F+M+EER  IAI
Sbjct: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209

Query: 180 KDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTL 238
           KDALNENSQLQ S KQL Q EAEVWK +VSELNKQK+TFEDSKVHAEQVLNDKE+HIKTL
Sbjct: 210 KDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269

Query: 239 TERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLK 298
           T  L  MKD AA+L ED TDDDNLELE+NS+ ENGA LD+P KGALKKLIHAAKLN SLK
Sbjct: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329

Query: 299 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTE 358
           +LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FE+ENQKLQQKLK+MTE
Sbjct: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389

Query: 359 LYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIH 418
            YQENEMKL+RKLTVEENYR+E+EEKLS+V+EKIS ATE LETYRK AKDLEEELERT+H
Sbjct: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVH 449

Query: 419 SYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDV 478
            YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTETELKFELLEKDP ALDV
Sbjct: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV 509

Query: 479 PNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLD 538
            NTAFGREHSP  PSPLG PSSETRAF SP TLLE PLRLSP+LPGGGGRG   PGNPLD
Sbjct: 510 SNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLD 569

Query: 539 HQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRF 598
           HQITNERGE S DRL DPHRAPSDTGSLS P +QDRRMMFPPPGQSYPDS LPPQR+DRF
Sbjct: 570 HQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRF 629

Query: 599 CSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEAT 658
            SNS RLSGPAE RSF M SLDKMD SMPSEMESSRND KDDLGNLNVPDSSLPAENEAT
Sbjct: 630 YSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689

Query: 659 GPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAP 718
           GPG +PPPLAPI GPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP DFPGPP AP
Sbjct: 690 GPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749

Query: 719 FAMRNVYPPRGFPPYLPPRPGFFPPP 744
           FAMRN+YPPRG PPYL PRPGF+P P
Sbjct: 750 FAMRNIYPPRGLPPYLHPRPGFYPNP 775


>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
            sapiens]
          Length = 1907

 Score =  265 bits (678), Expect = 9e-71
 Identities = 224/783 (28%), Positives = 369/783 (47%), Gaps = 108/783 (13%)

Query: 1    MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
            ++P  + YG PW+ V   A +G  +   FLWR+   V+ R+Y   E++++  L  +++E 
Sbjct: 1168 VQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKEN 1227

Query: 61   SKLLEKFSLVQ---KEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSE-LEDEI 116
            ++L++K S  +   KE + +  E+  ++     EA + +    T EK    N E L+D  
Sbjct: 1228 TELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEK----NQEILDDTA 1283

Query: 117  LCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLK 176
              L   L+ E+ ++ +  +L+++  K I+ L+D      S+ +E ++     +++EE++K
Sbjct: 1284 KNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVK 1343

Query: 177  IAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIK 236
                    EN++L++ ++QL QE E W +  +EL++Q  +FE S+   E  L  K+ +I 
Sbjct: 1344 SECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNIN 1403

Query: 237  TLTE-----RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAA 291
             LT       LL+ +  +    +   D D L     +  E G   +   K  +K+++  +
Sbjct: 1404 ALTNCITQLNLLECESESEGQNKGGNDSDEL-----ANGEVGGDRNEKMKNQIKQMMDVS 1458

Query: 292  KLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQ 351
            +   ++  +E +   + ++L     TK  L + +K L+ ++ SLQ+     E+E + L+Q
Sbjct: 1459 RTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQ 1518

Query: 352  KLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEE 411
            K++++ ELYQ+ EM L +KL+ EE  R E+E +LS  DEK   A EE++TY++R +++E+
Sbjct: 1519 KVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMED 1578

Query: 412  ELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEK 471
            EL++T  S++ QI +HEKKAH+NWL AR AER + + ++E A+ R KL E   K  +L++
Sbjct: 1579 ELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQE 1638

Query: 472  DPYAL----DVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGG 527
            +P  +      PNT       P   +    PS  +    SPP  +E P+R  PL      
Sbjct: 1639 EPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPPLTVEPPVR--PL------ 1690

Query: 528  RGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPD 587
                                ++ +R   P    S+ GS+  P         P P  S   
Sbjct: 1691 -------------------SATLNRRDMPR---SEFGSVDGP--------LPHPRWSAEA 1720

Query: 588  SALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNV- 646
            S  P        S S   SG A + +          GS P+ +         D G +N+ 
Sbjct: 1721 SGKP--------SPSDPGSGTATMMN------SSSRGSSPTRVL--------DEGKVNMA 1758

Query: 647  -----PDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGP-PFPPP-PPGAMF 699
                 P   +P  +   G G VPPP+    GP  P    GPF   GP P PPP  PG   
Sbjct: 1759 PKGPPPFPGVPLMSTPMG-GPVPPPIR--YGP--PPQLCGPF---GPRPLPPPFGPGMRP 1810

Query: 700  GASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLP-----PRPGFFPP---PPHSEGRS 751
                  F PG  PG    P   R   P  G  P+ P     PR  F P    PP + G  
Sbjct: 1811 PLGLREFAPGVPPGRRDLPLHPRGFLP--GHAPFRPLGSLGPREYFIPGTRLPPPTHGPQ 1868

Query: 752  EFP 754
            E+P
Sbjct: 1869 EYP 1871



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 87/430 (20%), Positives = 175/430 (40%), Gaps = 48/430 (11%)

Query: 51   LMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEK-LNRSN 109
            L++S   +E+  L ++F   QK +  +E+E+ L++ S + ++ + +SL    EK L++  
Sbjct: 924  LIISSFFKEQQSL-QRF---QKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVF 979

Query: 110  SELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQ 169
               E +IL + +++ + +   +       D+     ++ +E+  L               
Sbjct: 980  RASESQILSIAEKMLDTRVAENR------DLGMNENNIFEEAAVLDDIQDLIYFVRYKHS 1033

Query: 170  MNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQ-VL 228
              EE   + +   L E       + Q L E    +E+ +ELN   V   +   H +Q V+
Sbjct: 1034 TAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELN---VQVPEEPTHLDQRVI 1090

Query: 229  NDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLE-LEMNSESENGAYLDNPPKGALKKL 287
             D  +H   ++++    KD     G   T+D  ++ ++ N + E                
Sbjct: 1091 GD--THASEVSQKPNTEKDLDP--GPVTTEDTPMDAIDANKQPET--------------- 1131

Query: 288  IHAAKLNASLKTLEGERNQIYIQLSEVDKT-KEELTEHIK------NLQTEQASLQSENT 340
              AA+  AS+  LE     IY  +  + K+    L + ++       L  +   + +   
Sbjct: 1132 --AAEEPASVTPLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLG 1189

Query: 341  HFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELE 400
                     +  L V   +YQ  E ++  KL        E  +KLS  ++KI  + + ++
Sbjct: 1190 IASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQ 1249

Query: 401  TYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLT 460
              RK+   L +E  +    Y+ +I + EK        A+N    L   R++N  N+  ++
Sbjct: 1250 ETRKQNMILSDEAIK----YKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLIS 1305

Query: 461  ETELKFELLE 470
            E +   E L+
Sbjct: 1306 ENKKSIEKLK 1315


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 96/452 (21%), Positives = 197/452 (43%), Gaps = 44/452 (9%)

Query: 60  KSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCL 119
           +SK   + + ++++Y     E + K    ++E  + ++ E    +L     E E     +
Sbjct: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV 500

Query: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
           +  +++  ++H    +   D+  +  + E+E +SL S++ +  ++ +  +    +L  + 
Sbjct: 501 QSYIRKRTAEHEAAQQ---DLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557

Query: 180 KDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQ---VLNDKESHIK 236
           +  +N+   LQ   + +L++ E  K Q+ + + Q      + V AE+   V+ +K+  IK
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617

Query: 237 TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNAS 296
              + L   +D      E++ D  N+   + +E +    L N    A  +L         
Sbjct: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL--------- 668

Query: 297 LKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQ------ 350
               E  +  +Y++  ++   +E+L   I N   E   L  +N   ++E QKLQ      
Sbjct: 669 ----EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQ 724

Query: 351 ---QKLKVMTELYQENEMKLHRKLTVEENYRL------EKEEKLSKVDEKISHATEELET 401
                ++ M +  QE + KL    TVEE           KEE+L+ +  + S  T+E++ 
Sbjct: 725 PNKDVVEQMEKCIQEKDEKLK---TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD 781

Query: 402 YRKRAKD------LEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHN 455
            + +  D      L EEL++ IH   G+I S E+      L   N E+ + DL++E    
Sbjct: 782 LKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL 841

Query: 456 RQKLTETEL-KFELLEKDPYALDVPNTAFGRE 486
           ++++   +L K + L       ++ N   G+E
Sbjct: 842 KEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 102/442 (23%), Positives = 192/442 (43%), Gaps = 41/442 (9%)

Query: 46   EKKLALMLSGLIEEKSKLLE---------KFSLVQKEYEGYEVESSLKDASFEKEATEAQ 96
            EK   L ++  ++E   LL+         K  L +KE +       L+D   E E+ +A 
Sbjct: 851  EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAH 910

Query: 97   SLEATCEKLNRSNS-----ELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDES 151
              E     L  ++S     ELE  +   E ELK  ++   E++  ++  ++ +Q ++DE+
Sbjct: 911  VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 970

Query: 152  KSLKSQVAEAK----MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQV 207
            K  KSQ+ + K         F  +EE LK+ I +   E S L      L    E  +++ 
Sbjct: 971  KLFKSQIEQLKQQNYQQASSFPPHEELLKV-ISEREKEISGLWNELDSLKDAVEHQRKKN 1029

Query: 208  SELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMN 267
            ++L ++     ++    E++L DK +  KT  ER  ++ +   +  +++      ++ + 
Sbjct: 1030 NDLREKNWEAMEALASTEKMLQDKVN--KTSKERQQQV-EAVELEAKEVLKKLFPKVSVP 1086

Query: 268  SESENGAYLDNPPKGALKKLIHAAKLNASLKTLE---GERNQIYIQLS-EVDKTKEELTE 323
            S    G +L    K A K+ +     +  +K LE    E ++++  L  E +K K  L E
Sbjct: 1087 SNLSYGEWLHGFEKKA-KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1145

Query: 324  HIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVE---ENYRLE 380
                LQ  Q S++ E   ++ +  +  + +K M   +  +E +L R  +     EN R E
Sbjct: 1146 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1205

Query: 381  KEEKLSKVDEKISHATEELETY---RKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLA 437
            +E     ++ ++  A  E  TY    +  KDL  EL++ +     + +   ++ +   L 
Sbjct: 1206 REH----LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELN---LL 1258

Query: 438  ARNAERNLNDLRKENAHNRQKL 459
                   L  LR E  + RQK+
Sbjct: 1259 KAQLNETLTKLRTEQ-NERQKV 1279



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 58/305 (19%), Positives = 126/305 (41%), Gaps = 42/305 (13%)

Query: 169 QMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVL 228
           + ++E  ++  KD L     +  S+ + L   ++ KE+             S V  + + 
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEK-------------SGVIQDALK 320

Query: 229 NDKESHIKTLTERLLKMKDWAAMLGEDI--TDD--DNLELEMNSESENGAYLDNPPKGAL 284
              +  + TL  +L +     A + ED   T D    L  EM +E E             
Sbjct: 321 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE------------- 367

Query: 285 KKLIHAAKLNASLKTLEGE----RNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN- 339
           +  +   ++   + TLE E    +N+I++   E  + + +  +  + ++ E A L+ EN 
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427

Query: 340 ---THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHAT 396
                  N   +L+ K        +++  +L  +LT E+  +L++EE   K  E+   A 
Sbjct: 428 ILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELT-EKTGKLQQEEVQKKNAEQ---AA 483

Query: 397 EELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNR 456
            +L+   + A+   EE++  I     +  + ++     ++A  N  ++L+    +   ++
Sbjct: 484 TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSK 543

Query: 457 QKLTE 461
           Q+L +
Sbjct: 544 QQLEQ 548



 Score = 30.4 bits (67), Expect = 6.5
 Identities = 35/157 (22%), Positives = 71/157 (45%), Gaps = 12/157 (7%)

Query: 53   LSGLIEEKSKLLEKFSLVQKEYEGYEVE-SSLKDASFEKEATEAQSLEATCEKLNRSNSE 111
            +  L  E+  L  +    + E   Y  E   LKD   E +    + L+ +  +  R N E
Sbjct: 1199 IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQ----KKLDDSYSEAVRQNEE 1254

Query: 112  LEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLE-DESKSLKSQ-----VAEAKMTF 165
            L      L + L + +++ +E+ ++  D+ K  QSLE  +SK +K+      +  + ++ 
Sbjct: 1255 LNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSP 1314

Query: 166  KIFQMNEERLKIAIKDALNENSQ-LQESQKQLLQEAE 201
            +     +E + +++   + +  Q LQ   +QL +E E
Sbjct: 1315 ETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 96/452 (21%), Positives = 197/452 (43%), Gaps = 44/452 (9%)

Query: 60  KSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCL 119
           +SK   + + ++++Y     E + K    ++E  + ++ E    +L     E E     +
Sbjct: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV 500

Query: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
           +  +++  ++H    +   D+  +  + E+E +SL S++ +  ++ +  +    +L  + 
Sbjct: 501 QSYIRKRTAEHEAAQQ---DLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557

Query: 180 KDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQ---VLNDKESHIK 236
           +  +N+   LQ   + +L++ E  K Q+ + + Q      + V AE+   V+ +K+  IK
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617

Query: 237 TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNAS 296
              + L   +D      E++ D  N+   + +E +    L N    A  +L         
Sbjct: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL--------- 668

Query: 297 LKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQ------ 350
               E  +  +Y++  ++   +E+L   I N   E   L  +N   ++E QKLQ      
Sbjct: 669 ----EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQ 724

Query: 351 ---QKLKVMTELYQENEMKLHRKLTVEENYRL------EKEEKLSKVDEKISHATEELET 401
                ++ M +  QE + KL    TVEE           KEE+L+ +  + S  T+E++ 
Sbjct: 725 PNKDVVEQMEKCIQEKDEKLK---TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD 781

Query: 402 YRKRAKD------LEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHN 455
            + +  D      L EEL++ IH   G+I S E+      L   N E+ + DL++E    
Sbjct: 782 LKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL 841

Query: 456 RQKLTETEL-KFELLEKDPYALDVPNTAFGRE 486
           ++++   +L K + L       ++ N   G+E
Sbjct: 842 KEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 94/422 (22%), Positives = 179/422 (42%), Gaps = 63/422 (14%)

Query: 46   EKKLALMLSGLIEEKSKLLE---------KFSLVQKEYEGYEVESSLKDASFEKEATEAQ 96
            EK   L ++  ++E   LL+         K  L +KE +       L+D   E E+ +A 
Sbjct: 851  EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAH 910

Query: 97   SLEATCEKLNRSNS-----ELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDES 151
              E     L  ++S     ELE  +   E ELK  ++   E++  ++  ++ +Q ++DE+
Sbjct: 911  VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 970

Query: 152  KSLKSQVAEAK----MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQV 207
            K  KSQ+ + K         F  +EE LK+           + E +K++   + +W E  
Sbjct: 971  KLFKSQIEQLKQQNYQQASSFPPHEELLKV-----------ISEREKEI---SGLWNELD 1016

Query: 208  SELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMN 267
            S         +D+  H  +  N+++  ++ +    L+ K+    L   ++   NL     
Sbjct: 1017 S--------LKDAVEHQRKKNNERQQQVEAVE---LEAKEVLKKLFPKVSVPSNLSY--- 1062

Query: 268  SESENGAYLDNPPKGALKKLIHAAKLNASLKTLE---GERNQIYIQLS-EVDKTKEELTE 323
                 G +L    K A K+ +     +  +K LE    E ++++  L  E +K K  L E
Sbjct: 1063 -----GEWLHGFEKKA-KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1116

Query: 324  HIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVE---ENYRLE 380
                LQ  Q S++ E   ++ +  +  + +K M   +  +E +L R  +     EN R E
Sbjct: 1117 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1176

Query: 381  KEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARN 440
            +E     ++ ++  A  E  TY    ++L+ +L  T+   + +    +K A D   A ++
Sbjct: 1177 REH----LEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQS 1232

Query: 441  AE 442
             E
Sbjct: 1233 LE 1234



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 58/305 (19%), Positives = 126/305 (41%), Gaps = 42/305 (13%)

Query: 169 QMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVL 228
           + ++E  ++  KD L     +  S+ + L   ++ KE+             S V  + + 
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEK-------------SGVIQDALK 320

Query: 229 NDKESHIKTLTERLLKMKDWAAMLGEDI--TDD--DNLELEMNSESENGAYLDNPPKGAL 284
              +  + TL  +L +     A + ED   T D    L  EM +E E             
Sbjct: 321 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE------------- 367

Query: 285 KKLIHAAKLNASLKTLEGE----RNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN- 339
           +  +   ++   + TLE E    +N+I++   E  + + +  +  + ++ E A L+ EN 
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427

Query: 340 ---THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHAT 396
                  N   +L+ K        +++  +L  +LT E+  +L++EE   K  E+   A 
Sbjct: 428 ILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELT-EKTGKLQQEEVQKKNAEQ---AA 483

Query: 397 EELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNR 456
            +L+   + A+   EE++  I     +  + ++     ++A  N  ++L+    +   ++
Sbjct: 484 TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSK 543

Query: 457 QKLTE 461
           Q+L +
Sbjct: 544 QQLEQ 548


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 96/452 (21%), Positives = 197/452 (43%), Gaps = 44/452 (9%)

Query: 60  KSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCL 119
           +SK   + + ++++Y     E + K    ++E  + ++ E    +L     E E     +
Sbjct: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV 500

Query: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
           +  +++  ++H    +   D+  +  + E+E +SL S++ +  ++ +  +    +L  + 
Sbjct: 501 QSYIRKRTAEHEAAQQ---DLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557

Query: 180 KDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQ---VLNDKESHIK 236
           +  +N+   LQ   + +L++ E  K Q+ + + Q      + V AE+   V+ +K+  IK
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617

Query: 237 TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNAS 296
              + L   +D      E++ D  N+   + +E +    L N    A  +L         
Sbjct: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL--------- 668

Query: 297 LKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQ------ 350
               E  +  +Y++  ++   +E+L   I N   E   L  +N   ++E QKLQ      
Sbjct: 669 ----EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQ 724

Query: 351 ---QKLKVMTELYQENEMKLHRKLTVEENYRL------EKEEKLSKVDEKISHATEELET 401
                ++ M +  QE + KL    TVEE           KEE+L+ +  + S  T+E++ 
Sbjct: 725 PNKDVVEQMEKCIQEKDEKLK---TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD 781

Query: 402 YRKRAKD------LEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHN 455
            + +  D      L EEL++ IH   G+I S E+      L   N E+ + DL++E    
Sbjct: 782 LKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL 841

Query: 456 RQKLTETEL-KFELLEKDPYALDVPNTAFGRE 486
           ++++   +L K + L       ++ N   G+E
Sbjct: 842 KEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 102/442 (23%), Positives = 192/442 (43%), Gaps = 41/442 (9%)

Query: 46   EKKLALMLSGLIEEKSKLLE---------KFSLVQKEYEGYEVESSLKDASFEKEATEAQ 96
            EK   L ++  ++E   LL+         K  L +KE +       L+D   E E+ +A 
Sbjct: 851  EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAH 910

Query: 97   SLEATCEKLNRSNS-----ELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDES 151
              E     L  ++S     ELE  +   E ELK  ++   E++  ++  ++ +Q ++DE+
Sbjct: 911  VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 970

Query: 152  KSLKSQVAEAK----MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQV 207
            K  KSQ+ + K         F  +EE LK+ I +   E S L      L    E  +++ 
Sbjct: 971  KLFKSQIEQLKQQNYQQASSFPPHEELLKV-ISEREKEISGLWNELDSLKDAVEHQRKKN 1029

Query: 208  SELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMN 267
            ++L ++     ++    E++L DK +  KT  ER  ++ +   +  +++      ++ + 
Sbjct: 1030 NDLREKNWEAMEALASTEKMLQDKVN--KTSKERQQQV-EAVELEAKEVLKKLFPKVSVP 1086

Query: 268  SESENGAYLDNPPKGALKKLIHAAKLNASLKTLE---GERNQIYIQLS-EVDKTKEELTE 323
            S    G +L    K A K+ +     +  +K LE    E ++++  L  E +K K  L E
Sbjct: 1087 SNLSYGEWLHGFEKKA-KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1145

Query: 324  HIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVE---ENYRLE 380
                LQ  Q S++ E   ++ +  +  + +K M   +  +E +L R  +     EN R E
Sbjct: 1146 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1205

Query: 381  KEEKLSKVDEKISHATEELETY---RKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLA 437
            +E     ++ ++  A  E  TY    +  KDL  EL++ +     + +   ++ +   L 
Sbjct: 1206 REH----LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELN---LL 1258

Query: 438  ARNAERNLNDLRKENAHNRQKL 459
                   L  LR E  + RQK+
Sbjct: 1259 KAQLNETLTKLRTEQ-NERQKV 1279



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 58/305 (19%), Positives = 126/305 (41%), Gaps = 42/305 (13%)

Query: 169 QMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVL 228
           + ++E  ++  KD L     +  S+ + L   ++ KE+             S V  + + 
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEK-------------SGVIQDALK 320

Query: 229 NDKESHIKTLTERLLKMKDWAAMLGEDI--TDD--DNLELEMNSESENGAYLDNPPKGAL 284
              +  + TL  +L +     A + ED   T D    L  EM +E E             
Sbjct: 321 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE------------- 367

Query: 285 KKLIHAAKLNASLKTLEGE----RNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN- 339
           +  +   ++   + TLE E    +N+I++   E  + + +  +  + ++ E A L+ EN 
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427

Query: 340 ---THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHAT 396
                  N   +L+ K        +++  +L  +LT E+  +L++EE   K  E+   A 
Sbjct: 428 ILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELT-EKTGKLQQEEVQKKNAEQ---AA 483

Query: 397 EELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNR 456
            +L+   + A+   EE++  I     +  + ++     ++A  N  ++L+    +   ++
Sbjct: 484 TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSK 543

Query: 457 QKLTE 461
           Q+L +
Sbjct: 544 QQLEQ 548



 Score = 30.4 bits (67), Expect = 6.5
 Identities = 35/157 (22%), Positives = 71/157 (45%), Gaps = 12/157 (7%)

Query: 53   LSGLIEEKSKLLEKFSLVQKEYEGYEVE-SSLKDASFEKEATEAQSLEATCEKLNRSNSE 111
            +  L  E+  L  +    + E   Y  E   LKD   E +    + L+ +  +  R N E
Sbjct: 1199 IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQ----KKLDDSYSEAVRQNEE 1254

Query: 112  LEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLE-DESKSLKSQ-----VAEAKMTF 165
            L      L + L + +++ +E+ ++  D+ K  QSLE  +SK +K+      +  + ++ 
Sbjct: 1255 LNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSP 1314

Query: 166  KIFQMNEERLKIAIKDALNENSQ-LQESQKQLLQEAE 201
            +     +E + +++   + +  Q LQ   +QL +E E
Sbjct: 1315 ETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 108/453 (23%), Positives = 198/453 (43%), Gaps = 43/453 (9%)

Query: 50  ALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSN 109
           +L L   +E+ S+  E     QK   G+EV + L  +   K   E QSL  T E+L  + 
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSL-GHEV-NELTSSRLLKLEMENQSLTKTVEELRTTV 483

Query: 110 SELE---DEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFK 166
             +E    +IL +EKE +    K    +  +    + +Q+ ++ SK L  + A+ + T +
Sbjct: 484 DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543

Query: 167 IFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKE-QVSELNKQ------------ 213
             + N ER    IK    EN  L ++   L Q +++  E +V ++ K+            
Sbjct: 544 TLRENSER---QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600

Query: 214 ----KVTFEDSKVHAE-QVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNS 268
               K+ FE  ++  E +   +K    + L   L  ++    +L + IT+      ++ +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660

Query: 269 ESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNL 328
             +  + L+   +   K L     L   L++LE E +    QL E +       E +K  
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVESLKCA 716

Query: 329 QTEQASLQSENTHFENENQKLQQKLKVMTELYQENE-MKLHRKLTVEENYRLEKEEKLSK 387
             + A LQ EN   E+E ++L++ L+++   +++ E +++  +    EN RL+K   L  
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLEN 774

Query: 388 VDEKISHATEELETYRKRAKDLEEELER-TIHSYQGQIISHEKKAHDNWLAARNAERNLN 446
            ++KI     EL+      + L++ LE   I S + + +  E K+ +        E++  
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ--ETSQLEKDKK 832

Query: 447 DLRKENAHNRQK-------LTETELKFELLEKD 472
            L KEN   RQ+       L E  +K   LEK+
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 117/495 (23%), Positives = 203/495 (41%), Gaps = 84/495 (16%)

Query: 45   REKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFE-----KEATEAQSLE 99
            + ++L +   GL  E  +L +      K+ +  ++ES L+D   E     K   E +   
Sbjct: 750  KTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMENQTLQKNLEELKISS 807

Query: 100  ATCEKLNRSNSELEDEILCLEKELK--EEKSKHSEQ-----DELMADISKRIQSLEDESK 152
               E+L + N  LE E   LEK+ K  E+++K   Q     D  + + + +I +LE E+K
Sbjct: 808  KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867

Query: 153  SLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNK 212
            +L  ++   K +    +  E+  K  +K A  +   L   ++ L+ E    ++  ++L K
Sbjct: 868  TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 213  QKVTFEDSKVHAEQVLND--------------------------KESHIKTLTERLLKMK 246
                 E   ++ E++L+D                          KE  I  L  RL +  
Sbjct: 928  LTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST 987

Query: 247  DWAAMLGEDI-TDDDNLELEMNSESENGAYLDNPP----------------KGALK---K 286
            ++   L +++ T   N E     + E      +PP                +  LK   +
Sbjct: 988  NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1047

Query: 287  LIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENEN 346
            LI   + NA   TL+ E+  +  QL +++     L   I  LQ +  SLQ +NT  + +N
Sbjct: 1048 LIEVERNNA---TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104

Query: 347  QKLQQKLKVM----TELYQENEMKLHRKLTVE-ENYRLEKE-EKLSKVDEKISHATEELE 400
             KLQ +   +    T L  +N   L ++ ++E EN  + KE E L  + + +    E+LE
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1164

Query: 401  TYRKRAKDLEEELERTIHSYQGQIISHE--KKAHDNW-LAARNAERNLNDLRKENA--HN 455
                         ER    Y+  I  H   K AH N  +  R+ E   N L K+     +
Sbjct: 1165 LLH----------ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 1214

Query: 456  RQKLTETELKFELLE 470
             +K+ + E +  LLE
Sbjct: 1215 LEKMLKVEQEKMLLE 1229



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 115/476 (24%), Positives = 200/476 (42%), Gaps = 75/476 (15%)

Query: 36   SVRSRLYVGREKKLA------LMLSGLIEEKSKLLEKFSL----VQKEYEGY-------- 77
            S+R R  +  E ++        +L   I+E S  L K       ++KE E Y        
Sbjct: 569  SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628

Query: 78   EVESSLKDASFEKEATEAQ--SLEATCEK---LNRSNSELEDEILCLEKELKEEKSKHSE 132
            E+E+ L     E E  + +  +L+ TCEK   L + NSELE E   L+K L   K+    
Sbjct: 629  ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN---- 684

Query: 133  QDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALN---ENSQL 189
                   ++ +++SLE E+  L  +  E +        N E LK A         EN +L
Sbjct: 685  -------LTFQLESLEKENSQLDEENLELRR-------NVESLKCASMKMAQLQLENKEL 730

Query: 190  QESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWA 249
            +  ++QL +  E+ K    +  + +V+++   +  +++    E+  K + +   +++D  
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 250  AMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYI 309
                E+ T   NLE E+   S+    L+   K   ++    ++L    K LE E  ++  
Sbjct: 791  M---ENQTLQKNLE-ELKISSKRLEQLEKENKSLEQE---TSQLEKDKKQLEKENKRLRQ 843

Query: 310  QLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHR 369
            Q    D T EE    I NL+ E  +L  E   ++    +L++  K   EL +   + +  
Sbjct: 844  QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903

Query: 370  KLTVEENYRLE--KEEKLSKVDEKISHATE------------ELETYRKRAKDLEEELER 415
             +T+ E+   E  K ++++   EK++H  E            E  T   R K LE +LE 
Sbjct: 904  LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963

Query: 416  TIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEK 471
            T+   +   I  EK A          E  L +    N   RQ+L   +  +E L++
Sbjct: 964  TLK--KSLEIKEEKIA--------ALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 92/452 (20%), Positives = 200/452 (44%), Gaps = 48/452 (10%)

Query: 56  LIEEKSKLLE-KFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEAT-CEKLNRSNSELE 113
           L++ K +L + +  L + + E   + S  + A   ++  +A   +A   +KL    S  +
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333

Query: 114 DEILCLE------KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKI 167
           + +  +E      +ELKE+     E   ++ D  +  ++  D+   L+ +  + K     
Sbjct: 334 ERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD 393

Query: 168 FQMNEERLKIAIKDALNENSQLQESQKQLLQEA--EVWK-------EQVSELNKQKVTFE 218
            +M  +  +  I++ + EN  L+ +QKQ + E+    W+        ++SE  ++ +  E
Sbjct: 394 MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453

Query: 219 DSKVHAEQVLN---DKESHIKTLTE-------------RLLKMKDWAAMLGEDITDDDNL 262
            +++ + ++L    + +S  KT+ E             ++LKM+     L + +   + L
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV---EIL 510

Query: 263 ELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL-EGERNQIYIQLSEVDKTKEEL 321
           E E+  E ++     N  K  +K+    A+L  +++TL E    QI I    +++  E L
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIETLRENSERQIKI----LEQENEHL 563

Query: 322 TEHIKNL-QTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLE 380
            + + +L Q  Q S ++     E EN+ L + +K  +    + E +  R++  E  +  E
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE-KRQIKKELEHYKE 622

Query: 381 KEEKLSKVDEKISHATEELETYRKRAKDLEEELER--TIHSYQGQIISHEKKAHDNWLAA 438
           K E+  +++ ++ H  +E E  +K+  +L+   E+   +     ++    +K      + 
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682

Query: 439 RNAERNLNDLRKENAHNRQKLTETELKFELLE 470
           +N    L  L KEN+   ++  E     E L+
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLK 714



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 95/452 (21%), Positives = 201/452 (44%), Gaps = 79/452 (17%)

Query: 45   REKKLALMLSGLIEEKS---KLLEKFSLVQKEYEGYE--------VESSLKDASFEKEAT 93
            +E+K+A + + L E  +   +L ++   V+K YE  +        V+SS    S E    
Sbjct: 972  KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS-PPISGEDNKW 1030

Query: 94   EAQSLEATCEKLN---------RSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRI 144
            E +S E T E L          R+N+ L+ E   L+ +LK+ +++++     +  + ++ 
Sbjct: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090

Query: 145  QSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWK 204
             SL++++ +L++Q A+        Q+    L       +N+N+QL      L+Q++ +  
Sbjct: 1091 VSLQEQNTTLQTQNAK-------LQVENSTLNSQSTSLMNQNAQL------LIQQSSLEN 1137

Query: 205  EQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDIT---DDDN 261
            E  S + ++    ED K   + ++ D E  ++ L ER  +  ++ +++ +  T      N
Sbjct: 1138 ENESVIKER----EDLKSLYDSLIKDHEK-LELLHER--QASEYESLISKHGTLKSAHKN 1190

Query: 262  LELEMNSESENGAYLDNPPKGALKKLIHAAKL--------NASLKTLEGERNQIYIQLSE 313
            LE+E     +    L    KG L+ L    K+        N + +T+  E  ++  +   
Sbjct: 1191 LEVEHRDLEDRYNQLLKQ-KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249

Query: 314  VDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTV 373
            ++ T  +L +  + LQT+  +L+S   + + E  +L+ +   + E YQ+ ++      + 
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI-----TST 1304

Query: 374  EENYRLEKEEKL-SKVDEKISHATEELETYRKRAKDLEE---ELERTIHSYQGQIISHEK 429
            + N + E   +L   ++E+  H  ++++T   + + L E   E +   H  Q Q I    
Sbjct: 1305 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID--- 1361

Query: 430  KAHDNWLAARNAERNLNDLRKENAHNRQKLTE 461
                           LN+LR++     +K+ +
Sbjct: 1362 --------------KLNELRRQKEKLEEKIMD 1379



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 44/212 (20%), Positives = 86/212 (40%), Gaps = 11/212 (5%)

Query: 43   VGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATC 102
            +   + L  +   LI++  KL         EYE    +     ++ +    E + LE   
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1202

Query: 103  EKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAK 162
             +L +   +LED    LEK LK E+ K   +++    ++   + L  E+  L    ++  
Sbjct: 1203 NQLLKQKGQLED----LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1258

Query: 163  MTFKIFQMNEERLKIAIKDALNEN-------SQLQESQKQLLQEAEVWKEQVSELNKQKV 215
               ++ Q + + LK  + ++  E        S+L+E  +QL   +     Q   L++ K 
Sbjct: 1259 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1318

Query: 216  TFEDSKVHAEQVLNDKESHIKTLTERLLKMKD 247
              E+   H    +       +TL E+ ++ KD
Sbjct: 1319 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 44/198 (22%), Positives = 88/198 (44%), Gaps = 23/198 (11%)

Query: 44   GREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCE 103
            G   +L    S L++E   L      ++      ++E +  +A F K   + Q L+ T  
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304

Query: 104  KLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKM 163
            KLN      + E+L   K   EE+++H         +  +IQ+L  ++++L  Q  E+K 
Sbjct: 1305 KLNN-----QCELLSQLKGNLEEENRH---------LLDQIQTLMLQNRTLLEQNMESKD 1350

Query: 164  TFKIFQMNEERLKIAIKDALNE-NSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK- 221
             F +    E+R  I   D LNE   Q ++ +++++ + + +           +T +  K 
Sbjct: 1351 LFHV----EQRQYI---DKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKL 1403

Query: 222  VHAEQVLNDKESHIKTLT 239
            + +++ +N +     TLT
Sbjct: 1404 IKSKKDINRERQKSLTLT 1421


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 108/453 (23%), Positives = 198/453 (43%), Gaps = 43/453 (9%)

Query: 50  ALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSN 109
           +L L   +E+ S+  E     QK   G+EV + L  +   K   E QSL  T E+L  + 
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSL-GHEV-NELTSSRLLKLEMENQSLTKTVEELRTTV 483

Query: 110 SELE---DEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFK 166
             +E    +IL +EKE +    K    +  +    + +Q+ ++ SK L  + A+ + T +
Sbjct: 484 DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543

Query: 167 IFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKE-QVSELNKQ------------ 213
             + N ER    IK    EN  L ++   L Q +++  E +V ++ K+            
Sbjct: 544 TLRENSER---QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600

Query: 214 ----KVTFEDSKVHAE-QVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNS 268
               K+ FE  ++  E +   +K    + L   L  ++    +L + IT+      ++ +
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660

Query: 269 ESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNL 328
             +  + L+   +   K L     L   L++LE E +    QL E +       E +K  
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVESLKCA 716

Query: 329 QTEQASLQSENTHFENENQKLQQKLKVMTELYQENE-MKLHRKLTVEENYRLEKEEKLSK 387
             + A LQ EN   E+E ++L++ L+++   +++ E +++  +    EN RL+K   L  
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLEN 774

Query: 388 VDEKISHATEELETYRKRAKDLEEELER-TIHSYQGQIISHEKKAHDNWLAARNAERNLN 446
            ++KI     EL+      + L++ LE   I S + + +  E K+ +        E++  
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ--ETSQLEKDKK 832

Query: 447 DLRKENAHNRQK-------LTETELKFELLEKD 472
            L KEN   RQ+       L E  +K   LEK+
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 117/494 (23%), Positives = 203/494 (41%), Gaps = 83/494 (16%)

Query: 45   REKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFE-----KEATEAQSLE 99
            + ++L +   GL  E  +L +      K+ +  ++ES L+D   E     K   E +   
Sbjct: 750  KTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMENQTLQKNLEELKISS 807

Query: 100  ATCEKLNRSNSELEDEILCLEKELK--EEKSKHSEQ-----DELMADISKRIQSLEDESK 152
               E+L + N  LE E   LEK+ K  E+++K   Q     D  + + + +I +LE E+K
Sbjct: 808  KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867

Query: 153  SLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNK 212
            +L  ++   K +    +  E+  K  +K A  +   L   ++ L+ E    ++  ++L K
Sbjct: 868  TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 213  QKVTFEDSKVHAEQVLND-------------------------KESHIKTLTERLLKMKD 247
                 E   ++ E++L+D                         KE  I  L  RL +  +
Sbjct: 928  LTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 987

Query: 248  WAAMLGEDI-TDDDNLELEMNSESENGAYLDNPP----------------KGALK---KL 287
            +   L +++ T   N E     + E      +PP                +  LK   +L
Sbjct: 988  YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047

Query: 288  IHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQ 347
            I   + NA   TL+ E+  +  QL +++     L   I  LQ +  SLQ +NT  + +N 
Sbjct: 1048 IEVERNNA---TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104

Query: 348  KLQQKLKVM----TELYQENEMKLHRKLTVE-ENYRLEKE-EKLSKVDEKISHATEELET 401
            KLQ +   +    T L  +N   L ++ ++E EN  + KE E L  + + +    E+LE 
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL 1164

Query: 402  YRKRAKDLEEELERTIHSYQGQIISHE--KKAHDNW-LAARNAERNLNDLRKENA--HNR 456
                        ER    Y+  I  H   K AH N  +  R+ E   N L K+     + 
Sbjct: 1165 LH----------ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL 1214

Query: 457  QKLTETELKFELLE 470
            +K+ + E +  LLE
Sbjct: 1215 EKMLKVEQEKMLLE 1228



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 109/467 (23%), Positives = 203/467 (43%), Gaps = 58/467 (12%)

Query: 36   SVRSRLYVGREKKLA------LMLSGLIEEKSKLLEKFSL----VQKEYEGY-------- 77
            S+R R  +  E ++        +L   I+E S  L K       ++KE E Y        
Sbjct: 569  SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628

Query: 78   EVESSLKDASFEKEATEAQ--SLEATCEK---LNRSNSELEDEILCLEKELKEEKSKHSE 132
            E+E+ L     E E  + +  +L+ TCEK   L + NSELE E   L+K L   K+    
Sbjct: 629  ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN---- 684

Query: 133  QDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALN---ENSQL 189
                   ++ +++SLE E+  L  +  E +        N E LK A         EN +L
Sbjct: 685  -------LTFQLESLEKENSQLDEENLELRR-------NVESLKCASMKMAQLQLENKEL 730

Query: 190  QESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWA 249
            +  ++QL +  E+ K    +  + +V+++   +  +++    E+  K + +   +++D  
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 250  AMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYI 309
                E+ T   NLE E+   S+    L+   K   ++    ++L    K LE E  ++  
Sbjct: 791  M---ENQTLQKNLE-ELKISSKRLEQLEKENKSLEQE---TSQLEKDKKQLEKENKRLRQ 843

Query: 310  QLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHR 369
            Q    D T EE    I NL+ E  +L  E   ++    +L++  K   EL +   + +  
Sbjct: 844  QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903

Query: 370  KLTVEENYRLE--KEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISH 427
             +T+ E+   E  K ++++   EK++H  E++   ++R    E+  +      + ++ S 
Sbjct: 904  LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLEST 963

Query: 428  EKKA---HDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEK 471
             KK+    +  +AA   E  L +    N   RQ+L   +  +E L++
Sbjct: 964  LKKSLEIKEEKIAA--LEARLEESTNYNQQLRQELKTVKKNYEALKQ 1008



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 92/452 (20%), Positives = 200/452 (44%), Gaps = 48/452 (10%)

Query: 56  LIEEKSKLLE-KFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEAT-CEKLNRSNSELE 113
           L++ K +L + +  L + + E   + S  + A   ++  +A   +A   +KL    S  +
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333

Query: 114 DEILCLE------KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKI 167
           + +  +E      +ELKE+     E   ++ D  +  ++  D+   L+ +  + K     
Sbjct: 334 ERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD 393

Query: 168 FQMNEERLKIAIKDALNENSQLQESQKQLLQEA--EVWK-------EQVSELNKQKVTFE 218
            +M  +  +  I++ + EN  L+ +QKQ + E+    W+        ++SE  ++ +  E
Sbjct: 394 MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453

Query: 219 DSKVHAEQVLN---DKESHIKTLTE-------------RLLKMKDWAAMLGEDITDDDNL 262
            +++ + ++L    + +S  KT+ E             ++LKM+     L + +   + L
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV---EIL 510

Query: 263 ELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTL-EGERNQIYIQLSEVDKTKEEL 321
           E E+  E ++     N  K  +K+    A+L  +++TL E    QI I    +++  E L
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIETLRENSERQIKI----LEQENEHL 563

Query: 322 TEHIKNL-QTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLE 380
            + + +L Q  Q S ++     E EN+ L + +K  +    + E +  R++  E  +  E
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE-KRQIKKELEHYKE 622

Query: 381 KEEKLSKVDEKISHATEELETYRKRAKDLEEELER--TIHSYQGQIISHEKKAHDNWLAA 438
           K E+  +++ ++ H  +E E  +K+  +L+   E+   +     ++    +K      + 
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682

Query: 439 RNAERNLNDLRKENAHNRQKLTETELKFELLE 470
           +N    L  L KEN+   ++  E     E L+
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLK 714



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 95/452 (21%), Positives = 201/452 (44%), Gaps = 79/452 (17%)

Query: 45   REKKLALMLSGLIEEKS---KLLEKFSLVQKEYEGYE--------VESSLKDASFEKEAT 93
            +E+K+A + + L E  +   +L ++   V+K YE  +        V+SS    S E    
Sbjct: 971  KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS-PPISGEDNKW 1029

Query: 94   EAQSLEATCEKLN---------RSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRI 144
            E +S E T E L          R+N+ L+ E   L+ +LK+ +++++     +  + ++ 
Sbjct: 1030 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089

Query: 145  QSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWK 204
             SL++++ +L++Q A+        Q+    L       +N+N+QL      L+Q++ +  
Sbjct: 1090 VSLQEQNTTLQTQNAK-------LQVENSTLNSQSTSLMNQNAQL------LIQQSSLEN 1136

Query: 205  EQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDIT---DDDN 261
            E  S + ++    ED K   + ++ D E  ++ L ER  +  ++ +++ +  T      N
Sbjct: 1137 ENESVIKER----EDLKSLYDSLIKDHEK-LELLHER--QASEYESLISKHGTLKSAHKN 1189

Query: 262  LELEMNSESENGAYLDNPPKGALKKLIHAAKL--------NASLKTLEGERNQIYIQLSE 313
            LE+E     +    L    KG L+ L    K+        N + +T+  E  ++  +   
Sbjct: 1190 LEVEHRDLEDRYNQLLKQ-KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1248

Query: 314  VDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTV 373
            ++ T  +L +  + LQT+  +L+S   + + E  +L+ +   + E YQ+ ++      + 
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI-----TST 1303

Query: 374  EENYRLEKEEKL-SKVDEKISHATEELETYRKRAKDLEE---ELERTIHSYQGQIISHEK 429
            + N + E   +L   ++E+  H  ++++T   + + L E   E +   H  Q Q I    
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID--- 1360

Query: 430  KAHDNWLAARNAERNLNDLRKENAHNRQKLTE 461
                           LN+LR++     +K+ +
Sbjct: 1361 --------------KLNELRRQKEKLEEKIMD 1378



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 44/212 (20%), Positives = 86/212 (40%), Gaps = 11/212 (5%)

Query: 43   VGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATC 102
            +   + L  +   LI++  KL         EYE    +     ++ +    E + LE   
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1201

Query: 103  EKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAK 162
             +L +   +LED    LEK LK E+ K   +++    ++   + L  E+  L    ++  
Sbjct: 1202 NQLLKQKGQLED----LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1257

Query: 163  MTFKIFQMNEERLKIAIKDALNEN-------SQLQESQKQLLQEAEVWKEQVSELNKQKV 215
               ++ Q + + LK  + ++  E        S+L+E  +QL   +     Q   L++ K 
Sbjct: 1258 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1317

Query: 216  TFEDSKVHAEQVLNDKESHIKTLTERLLKMKD 247
              E+   H    +       +TL E+ ++ KD
Sbjct: 1318 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1349



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 44/198 (22%), Positives = 88/198 (44%), Gaps = 23/198 (11%)

Query: 44   GREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCE 103
            G   +L    S L++E   L      ++      ++E +  +A F K   + Q L+ T  
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303

Query: 104  KLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKM 163
            KLN      + E+L   K   EE+++H         +  +IQ+L  ++++L  Q  E+K 
Sbjct: 1304 KLNN-----QCELLSQLKGNLEEENRH---------LLDQIQTLMLQNRTLLEQNMESKD 1349

Query: 164  TFKIFQMNEERLKIAIKDALNE-NSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK- 221
             F +    E+R  I   D LNE   Q ++ +++++ + + +           +T +  K 
Sbjct: 1350 LFHV----EQRQYI---DKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKL 1402

Query: 222  VHAEQVLNDKESHIKTLT 239
            + +++ +N +     TLT
Sbjct: 1403 IKSKKDINRERQKSLTLT 1420


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 108/491 (21%), Positives = 222/491 (45%), Gaps = 48/491 (9%)

Query: 25   AVLFFLW--RSFRSVRSRLYVGREKKLALMLSGLIEEK--SKLLEKFSLVQKEYEGYEV- 79
            A+L   W  R+F  V++  ++    K+  +L     EK  + + E+F  +++  E  E  
Sbjct: 812  ALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEAR 871

Query: 80   --ESSLKDASFEKEATEAQ-SLEATCEKLNRSNSELEDEI---LCLEKELKEEKSKHSEQ 133
              E   K  S  +E  + Q  ++A  + LN +    +  I   + LE ++KE   +  ++
Sbjct: 872  RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDE 931

Query: 134  DELMADISKRIQSLEDESKSLKSQVAEAKMTF------------KIFQMNEER--LKIAI 179
            +E+ A+++ + + LEDE   LK  + + ++T             K+  + EE   L   I
Sbjct: 932  EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991

Query: 180  KDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLT 239
                 E   LQE+ +Q L + +V +++V+ L+K KV  E      E  L  ++     L 
Sbjct: 992  AKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLE 1051

Query: 240  ERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALK-KLIHAAKLNASLK 298
                K++    +  E I D +N +L++  + +   +  N     ++ + + A +L   LK
Sbjct: 1052 RAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLK 1111

Query: 299  TLEGERNQIYIQL-------SEVDKTKEELTEHIKNL--QTEQA----SLQSE-NTHFEN 344
              +    ++  +L       ++V+K + +L+  ++ +  + E+A    S+Q E N   E 
Sbjct: 1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1171

Query: 345  ENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRK 404
            E QK+++ L+  T  ++     L +K         E+ + L +V +K+    +E   ++ 
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE---KEKSEFKL 1228

Query: 405  RAKDLEEELERTIHSYQG-QIISH--EKKAHDNWLAARNAERNLNDLRKENAHNRQKLTE 461
               D+   +E+ I +    + +S   E +A++  +    A+R+LND   + A  + +   
Sbjct: 1229 ELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA--KLQTEN 1286

Query: 462  TELKFELLEKD 472
             EL  +L EK+
Sbjct: 1287 GELARQLEEKE 1297



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 99/447 (22%), Positives = 195/447 (43%), Gaps = 61/447 (13%)

Query: 47   KKLALMLSGLIE---EKSKLLEKFSLVQK--EYEGYEVESSLKDASFEKEATEAQSLEAT 101
            K L   +S L E   E  K + +   V+K  E E  E++S+L++A    E  E + L A 
Sbjct: 1505 KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQ 1564

Query: 102  CEKLNRSNSELEDEILCLEKELKEEKSKH-----SEQDELMADISKR------------- 143
             E  N+  +E+E ++   ++E+++ K  H     S Q  L A+   R             
Sbjct: 1565 LE-FNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGD 1623

Query: 144  IQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVW 203
            +  +E +        AEA+   K  Q   +  +I + DA+  N  L+E+   + +   + 
Sbjct: 1624 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683

Query: 204  KEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLE 263
            + ++ EL       E S+  AEQ L +    ++ L  +   + +    +  D+T      
Sbjct: 1684 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLT------ 1737

Query: 264  LEMNSESENGAY-LDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELT 322
             ++ SE E       N  + A K +  AA +   LK  +          + +++ K+ + 
Sbjct: 1738 -QLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS-------AHLERMKKNME 1789

Query: 323  EHIKNLQ-----TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENY 377
            + IK+LQ      EQ +L+      + + QKL+ +++ +     E E++  +K   E   
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGG----KKQLQKLEARVREL-----EGELEAEQKRNAESVK 1840

Query: 378  RLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLA 437
             + K E+  K   ++++ TEE +    R +DL ++L+  + +Y+ Q    E++A+ N   
Sbjct: 1841 GMRKSERRIK---ELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1897

Query: 438  ARNAERNLNDLRKENAHNRQKLTETEL 464
             R  +  L++     A  R  + E+++
Sbjct: 1898 FRKVQHELDE-----AEERADIAESQV 1919



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 87/411 (21%), Positives = 172/411 (41%), Gaps = 44/411 (10%)

Query: 80   ESSLKDASFEKEATEA-QSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMA 138
            E+  K A   ++A EA +++ A C  L ++   L++EI  L  +++   +  +  D+   
Sbjct: 1390 EAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449

Query: 139  DISKRI----QSLEDESKSLKSQVAEAKM----TFKIFQMNEERLKIAIKDALNENSQLQ 190
            +  K +    Q  E+    L+S   EA+      FK+    EE L+  ++    EN  LQ
Sbjct: 1450 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE-HLETFKRENKNLQ 1508

Query: 191  ESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAA 250
            E    L ++     + V EL K +   E  K+  +  L + E+ ++    ++L+ +    
Sbjct: 1509 EEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFN 1568

Query: 251  MLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNAS-----LKTLEGERN 305
             +  +I   +    E + E E           +L+  + A   + +      K +EG+ N
Sbjct: 1569 QIKAEI---ERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN 1625

Query: 306  QIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEM 365
            ++ IQLS  ++   E  + +K+LQ+     Q +       N  L++ + +          
Sbjct: 1626 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI---------- 1675

Query: 366  KLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRA-KDLEEELERT--IHSYQG 422
                   VE    L + E      E++    E+ E  RK A ++L E  ER   +HS   
Sbjct: 1676 -------VERRNNLLQAEL-----EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1723

Query: 423  QIISHEKKAHDNWLAARN-AERNLNDLRKENAHNRQKLTETELKFELLEKD 472
             +I+ +KK   +    ++  E  + + R      ++ +T+  +  E L+K+
Sbjct: 1724 SLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1774



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 92/422 (21%), Positives = 170/422 (40%), Gaps = 34/422 (8%)

Query: 78   EVESSLKDASFE--KEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDE 135
            E + SL D + +  K  TE   L    E+     S+L    L   +++++ K +  E+ +
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326

Query: 136  LMADISKRIQSLEDESKSLKSQV-----AEAKMTFKIFQMNEERLKIAIK---DALNENS 187
                ++  +QS   +   L+ Q      A+A++   + + N E  +   K   DA+    
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1386

Query: 188  QLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK----VHAEQVLNDKESHIKTLTERLL 243
            +L+E++K+L Q  +  +E V  +N +  + E +K       E ++ D E           
Sbjct: 1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1446

Query: 244  KMKDWAAMLGEDITDDDNLELEMNSESENGAYLDN---PPKGALKK-LIHAAKLNASLKT 299
            K +++  +L E     +  + E+ S  +    L       K A ++ L H        K 
Sbjct: 1447 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1506

Query: 300  LEGERNQIYIQLSEVDKTKEELTEHIKNLQTE----QASLQSENTHFENENQKLQQKLKV 355
            L+ E + +  QL E  K   EL +  K L+ E    Q++L+      E+E  K+ +    
Sbjct: 1507 LQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE 1566

Query: 356  MTELYQENEMKLHRK----LTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEE 411
              ++  E E KL  K       + N++   +   + +D +     E L   +K   DL E
Sbjct: 1567 FNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNE 1626

Query: 412  ------ELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENA--HNRQKLTETE 463
                     R     Q Q+ S +    D  +   +A R  +DL++  A    R  L + E
Sbjct: 1627 MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE 1686

Query: 464  LK 465
            L+
Sbjct: 1687 LE 1688



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 92/437 (21%), Positives = 182/437 (41%), Gaps = 75/437 (17%)

Query: 65   EKFSLVQKEYEGYEVES-SLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKEL 123
            +K+   Q E E  + E+ SL    F+ +    +SLE   E   R N  L++EI  L ++L
Sbjct: 1460 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL-ETFKRENKNLQEEISDLTEQL 1518

Query: 124  KEE-KSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTF-----KIF--QMNEERL 175
             E  K+ H        ++ K  + LE E   L+S + EA+ +      KI   Q+   ++
Sbjct: 1519 GEGGKNVH--------ELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570

Query: 176  KIAIKDALNENSQLQESQKQLLQEA-------------------EVWKEQVSELNKQKVT 216
            K  I+  L E  +  E  K+  Q                      V K+   +LN+ ++ 
Sbjct: 1571 KAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQ 1630

Query: 217  FEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYL 276
                  HA ++  + +  +K+L   L   KD    L + +  +D+L+       EN A +
Sbjct: 1631 LS----HANRMAAEAQKQVKSLQSLL---KDTQIQLDDAVRANDDLK-------ENIAIV 1676

Query: 277  DNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQ 336
            +               L A L+ L     Q        ++   E +E ++ L ++  SL 
Sbjct: 1677 ER----------RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726

Query: 337  SENTHFENENQKLQQKLKVMTELYQENEMKLHRKLT----VEENYRLEKE-----EKLSK 387
            ++    E++  +LQ +++   +  +  E K  + +T    + E  + E++     E++ K
Sbjct: 1727 NQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1786

Query: 388  VDEK----ISHATEELETYR-KRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAE 442
              E+    + H  +E E    K  K   ++LE  +   +G++ + +K+  ++    R +E
Sbjct: 1787 NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSE 1846

Query: 443  RNLNDLRKENAHNRQKL 459
            R + +L  +   +++ L
Sbjct: 1847 RRIKELTYQTEEDKKNL 1863



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 35/161 (21%), Positives = 78/161 (48%), Gaps = 16/161 (9%)

Query: 79   VESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMA 138
            +E ++KD     +  E  +L+   ++L +    LE  +  LE EL+ E+ +++E  + M 
Sbjct: 1788 MEQTIKDLQHRLDEAEQIALKGGKKQLQK----LEARVRELEGELEAEQKRNAESVKGMR 1843

Query: 139  DISKRIQSL-----EDESKSLKSQ--VAEAKMTFKIFQMNEERLKIAIKDALNENSQLQE 191
               +RI+ L     ED+   L+ Q  V + ++  K ++   E  +      L++  ++Q 
Sbjct: 1844 KSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQH 1903

Query: 192  SQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE 232
               +  + A++ + QV++L       +   + A+Q ++D+E
Sbjct: 1904 ELDEAEERADIAESQVNKLRA-----KSRDIGAKQKMHDEE 1939


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 100/424 (23%), Positives = 199/424 (46%), Gaps = 62/424 (14%)

Query: 78   EVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELM 137
            E E   KD    K   +   +E   E++ R + +L +E   L ++L+ E    +E +E+ 
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910

Query: 138  ADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLL 197
            A ++ + Q LE+    L+S+V E +   +I Q  +++++  I+D L E    +E  +Q L
Sbjct: 911  ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD-LEEQLDEEEGARQKL 969

Query: 198  QEAEVWKEQVSELNKQKVTFEDS-KVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDI 256
            Q              +KVT E   K   E++L  ++ + K + E+ L M+D  A     +
Sbjct: 970  Q-------------LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL-MEDRIAECSSQL 1015

Query: 257  TDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDK 316
             +++        +++N A + N      K+ +  + L   LK  E  R        E++K
Sbjct: 1016 AEEE-------EKAKNLAKIRN------KQEVMISDLEERLKKEEKTR-------QELEK 1055

Query: 317  TKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVM------TELYQENEMKLHRK 370
             K +L     +LQ + A LQ++    + +  K +++L+          L++ N +K+ R+
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115

Query: 371  L-----TVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERT-----IHSY 420
            L      ++E++  EK  + +K +++    +EELE  +    +LE+ L+ T     + + 
Sbjct: 1116 LQAQIAELQEDFESEKASR-NKAEKQKRDLSEELEALK---TELEDTLDTTAAQQELRTK 1171

Query: 421  QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLT---ETELKFEL-LEKDPYAL 476
            + Q ++  KKA +     +N E  + D+R+ +A   ++L+   E   +F+  LEK+   L
Sbjct: 1172 REQEVAELKKALEE--ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 1229

Query: 477  DVPN 480
            +  N
Sbjct: 1230 ETDN 1233



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 107/475 (22%), Positives = 197/475 (41%), Gaps = 65/475 (13%)

Query: 44   GREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCE 103
            G  +KL L       +  K+ E+  L++ +   +  E  L +    + +++    E   +
Sbjct: 964  GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023

Query: 104  KLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKM 163
             L +  ++ E  I  LE+ LK+E+    E ++    +      L+D+   L++Q+ E K+
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083

Query: 164  TFKIFQMNEERLKIAI----KDALNENSQLQ----------------ESQKQLLQEAEVW 203
                    EE L+ A+     + L++N+ L+                ES+K    +AE  
Sbjct: 1084 Q---LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140

Query: 204  KEQVS-ELNKQKVTFEDS--KVHAEQVLNDK------------ESHIKTLTERLLKMKDW 248
            K  +S EL   K   ED+     A+Q L  K            E   K    ++  M+  
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200

Query: 249  AAMLGEDITD--DDNLELEMNSE-SENGAYLDNPPKGALKKLIHAAKLNA--SLKTLEGE 303
             A   E++++  +     + N E ++ G   DN       K++   K  +    K L+ +
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260

Query: 304  RNQIYIQLSEVDKTKEELTEHIKNLQTEQASL-------QSENTHFENENQKLQQKLKVM 356
              +++ ++SE D+ + EL E    LQ E  ++       + +   F  +   L+ +L+  
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320

Query: 357  TELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERT 416
             EL QE   +  +KL +    R  +EEK S  +++     EE E  RK        LE+ 
Sbjct: 1321 QELLQE---ETRQKLNLSSRIRQLEEEKNSLQEQQ-----EEEEEARK-------NLEKQ 1365

Query: 417  IHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEK 471
            + + Q Q+   +KK  D+     + E     L K+     Q+L E  L ++ LEK
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1420



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 117/485 (24%), Positives = 205/485 (42%), Gaps = 43/485 (8%)

Query: 31   WRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESS--LKDASF 88
            WR F  V+  L V R+++    L    EE  K+ EK + V+ E E  E +    L++ + 
Sbjct: 835  WRVFTKVKPLLQVTRQEE---ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI 891

Query: 89   EKEATEAQS-----LEATCEKLNRSNSELEDEILCLEKELKEEKSKH----SEQDELMAD 139
              E  +A++      E    +L     ELE+ +  LE  ++EE+ ++    +E+ ++ A 
Sbjct: 892  LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951

Query: 140  ISKRIQSL-EDESKSLKSQVAEAKMTFKIFQMNEERLKIA------IKDALNENSQLQES 192
            I    + L E+E    K Q+ +     KI +M EE L +       IK+      ++ E 
Sbjct: 952  IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011

Query: 193  QKQLLQEAEVWKEQVSELNKQKVTFEDSKVH---AEQVLNDKESHIKTLTERLLKMKDWA 249
              QL +E E  K      NKQ+V   D +      E+   + E   + L      ++D  
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071

Query: 250  AMLGEDITDDDNLELEMNSESENGAYL--DNPPKGALKKLIHAAKLNASLKTLEGERNQI 307
            A L   I D+  L+L    E   GA    D+        L    +L A +  L+ +    
Sbjct: 1072 AELQAQI-DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130

Query: 308  YIQLSEVDKTKEELTEHIKNLQTE-------QASLQSENTHFENENQKLQQKLKVMTELY 360
                ++ +K K +L+E ++ L+TE        A+ Q   T  E E  +L++ L+  T+ +
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190

Query: 361  --QENEMKLHRKLTVEE-NYRLEKEEK----LSKVDEKISHATEELETYRKRAKDLEEEL 413
              Q  +M+      +EE + +LE+ ++    L K  + +    +EL    K  + ++ E 
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 414  ERTIHSYQGQIIS-HEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKD 472
            E        Q+   H K +  + L    AE+  + L+ E  +    L E E K     KD
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEK-ASKLQNELDNVSTLLEEAEKKGIKFAKD 1309

Query: 473  PYALD 477
              +L+
Sbjct: 1310 AASLE 1314



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 107/483 (22%), Positives = 200/483 (41%), Gaps = 89/483 (18%)

Query: 56   LIEEKSKL---LEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSL--EATCEKLNRSNS 110
            L E+ SKL   L+  S + +E E   ++ +   AS E +  + Q L  E T +KLN S+ 
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337

Query: 111  ELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQM 170
                      ++L+EEK+   EQ E   +  K   +LE +  +L+SQ+A+ K        
Sbjct: 1338 I---------RQLEEEKNSLQEQQEEEEEARK---NLEKQVLALQSQLADTKKK------ 1379

Query: 171  NEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSEL-----------NKQKVTFED 219
                    + D L     L+E++K+LL++AE   +++ E            N+ +   +D
Sbjct: 1380 --------VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431

Query: 220  SKV---HAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYL 276
              V   H  QV ++ E   K   + L + K  +A   E+    D  E E   +      L
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE---RDRAEAEAREKETKALSL 1488

Query: 277  DNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQ 336
                + AL+      + N   K L  +   +     +V K   EL +  + L+ +   ++
Sbjct: 1489 ARALEEALEAKEEFERQN---KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545

Query: 337  SENTHFENENQKLQQ-KLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHA 395
            ++    E+E Q  +  KL++   + Q  + +  R L   +    EK+  L K   ++   
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNM-QAMKAQFERDLQTRDEQNEEKKRLLIK---QVREL 1601

Query: 396  TEELETYRKR--------------AKDLEEELE----------RTIHSYQGQIISHEKKA 431
              ELE  RK+               KDLE ++E          + +   Q Q+  ++++ 
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661

Query: 432  HDN-------WLAARNAERNLNDLRKENAHNRQKLTETE--LKFELLEKDPYALDVPNTA 482
             +        +  ++ +E+ L  L  E    +++L  +E   +    E+D  A ++ N+A
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721

Query: 483  FGR 485
             G+
Sbjct: 1722 SGK 1724



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 85/411 (20%), Positives = 163/411 (39%), Gaps = 52/411 (12%)

Query: 71   QKEYEGYEVESSLKDASFEKEATEAQS--LEATCEKLNRSNSELEDEILCLEKELKEEKS 128
            +KE +   +  +L++A   KE  E Q+  L A  E L  S  ++   +  LEK  +  + 
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539

Query: 129  KHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIF-----QMNEERLKIAIKDAL 183
            +  E    + ++   +Q+ ED    L+  +   K  F+       + NEE+ ++ IK   
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599

Query: 184  NENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLL 243
               ++L++ +KQ           V+   K ++  +D +   E     ++  IK L +   
Sbjct: 1600 ELEAELEDERKQRALA-------VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQA 1652

Query: 244  KMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGE 303
            +MKD+   L E     D +    + ESE                         LK+LE E
Sbjct: 1653 QMKDYQRELEEARASRDEI-FAQSKESEK-----------------------KLKSLEAE 1688

Query: 304  RNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQEN 363
              Q+  +L+  ++ +    +    L  E  +  S  +   +E ++L+ ++  + E  +E 
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748

Query: 364  EMKLH------RKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTI 417
            +  +       RK T++ +    +        +K  +A ++LE   K  K   +ELE  +
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808

Query: 418  HS-YQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFE 467
             S ++  I + E K           E  L    KE A   + +  TE K +
Sbjct: 1809 KSKFKATISALEAK-------IGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 90/444 (20%), Positives = 172/444 (38%), Gaps = 58/444 (13%)

Query: 53   LSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSEL 112
            +  L E K KLL+    + +  E   +     + +  +   E   L    +   +  S L
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL 1446

Query: 113  EDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNE 172
            E +    ++ L EEKS  +   E         +  E ++ SL   + EA    + F+   
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506

Query: 173  ERLKIAIKDALNENS-------QLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHA- 224
            ++L+  ++D ++          +L++S++ L Q+ E  + Q+ EL  +    ED+K+   
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566

Query: 225  ------------------EQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEM 266
                              EQ    K   IK + E   +++D        +     +E+++
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626

Query: 267  NSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGE-------RNQIYIQLSEVDKTKE 319
                +  A ++   K   + +    KL A +K  + E       R++I+ Q  E +K  +
Sbjct: 1627 ---KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683

Query: 320  ELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRL 379
             L   I  LQ E AS +    H E E  +L  ++               +   ++E  RL
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADEI---------TNSASGKSALLDEKRRL 1734

Query: 380  EKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAAR 439
            E          +I+   EELE  +   + L +   +T  + Q   ++ E  A  +  AA+
Sbjct: 1735 E---------ARIAQLEEELEEEQSNMELLNDRFRKT--TLQVDTLNAELAAERS--AAQ 1781

Query: 440  NAERNLNDLRKENAHNRQKLTETE 463
             ++     L ++N   + KL E E
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELE 1805



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 41/200 (20%), Positives = 75/200 (37%), Gaps = 57/200 (28%)

Query: 54   SGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEK--------------EATEAQSLE 99
            S L++EK +L  + + +++E E  +    L +  F K              E + AQ  +
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD 1784

Query: 100  ATCEKLNRSNSEL----------------------EDEILCLEKELKEEKSKHSEQDELM 137
               ++L R N EL                      E +I  LE++L++E  + +  ++L+
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844

Query: 138  ADISKRIQSL----EDES-----------------KSLKSQVAEAKMTFKIFQMNEERLK 176
                K+++ +    EDE                  K LK Q+ EA+        +  +L+
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904

Query: 177  IAIKDALNENSQLQESQKQL 196
              + DA   N  L      L
Sbjct: 1905 RELDDATEANEGLSREVSTL 1924


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 77/430 (17%), Positives = 187/430 (43%), Gaps = 34/430 (7%)

Query: 48  KLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNR 107
           +L   LS +  +K K       + KE +   +E      + E+   +   L+   + +  
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 223

Query: 108 SNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKI 167
             SE++  +  L+++L+  K    +Q +L A+     + L+  S  L++QV E ++  ++
Sbjct: 224 EKSEIQLNVKELKRKLERAKLLLPQQ-QLQAEADHLGKELQSVSAKLQAQVEENELWNRL 282

Query: 168 FQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTF---EDSKVHA 224
            Q  EE++         +  ++QE ++++ ++ E  +EQ  ++ +Q+      E+     
Sbjct: 283 NQQQEEKM-------WRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 335

Query: 225 EQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGAL 284
           E+++ +KE  I+ L E++ +         E I + +    E   E E     +   +   
Sbjct: 336 EEMMWEKEEKIRELEEKMHEQ--------EKIREQE----EKRQEEEKIREQEKRQEQEA 383

Query: 285 KKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFEN 344
           K      K+    + +  +   +  Q  ++ + +E++ E  + +Q ++  ++ +      
Sbjct: 384 KMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE 443

Query: 345 ENQKL---QQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELET 401
           + +K+   ++K++   E+ QE E K+      +E    E+E K+ + +EK+    E++  
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGE----QEGKMCEQEAKMQEQEEKMRRQEEKIRE 499

Query: 402 YRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTE 461
             K+ ++ EE++       Q Q    E+K  +        E  + +  ++     +K+ E
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQ----EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMRE 555

Query: 462 TELKFELLEK 471
            E++    E+
Sbjct: 556 QEVRLRQQEE 565



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 65/381 (17%), Positives = 169/381 (44%), Gaps = 41/381 (10%)

Query: 56  LIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEA----QSLEATCEKLNRSNSE 111
           L E+ +KL EK  LV+ E    E++ ++K+   + E  +     Q L+A  + L +    
Sbjct: 207 LKEKNAKLQEKLQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 264

Query: 112 LEDEILCLEKELKEEKSKHSEQDELM----ADISKRIQSLEDESKSLKSQVAEAKMTFKI 167
           +  ++    +E +     + +Q+E M      I +R + ++++ + ++ Q  + +   ++
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEM 324

Query: 168 FQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQV 227
               EE+++   +    +  +++E ++++ ++ ++ +++     ++K+  ++ +   E  
Sbjct: 325 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384

Query: 228 LNDKESHIKTLTERLLK----MKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGA 283
           +  +E  I+   E++ +    M++    +GE        E EM  + E            
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEE------------ 432

Query: 284 LKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFE 343
            K      K+    K +  +  +I  Q   + + +E++ E    +  ++A +Q +     
Sbjct: 433 -KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR 491

Query: 344 NENQKL----------QQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKIS 393
            + +K+          ++K++   E+ QE E K+      +E    E+EEK+ + +EK+ 
Sbjct: 492 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE----QEEKMCEQEEKMQEQEEKMR 547

Query: 394 HATEELETYRKRAKDLEEELE 414
              E++     R +  EE+++
Sbjct: 548 RQEEKMREQEVRLRQQEEKMQ 568



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 75/380 (19%), Positives = 156/380 (41%), Gaps = 41/380 (10%)

Query: 106 NRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTF 165
           N +N E      C   E  E+K+ H  Q+ L  ++  ++Q++    + L  Q  E +M  
Sbjct: 80  NGTNPETTTSGGCHSPE-DEQKASHQHQEALRRELEAQVQTI----RILTCQKTELQMAL 134

Query: 166 KIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAE 225
              Q   ++L+   +D +   S+L +S K    E E     V+   K+   + +      
Sbjct: 135 YYSQHAVKQLEGEARDLI---SRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKER 190

Query: 226 QVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALK 285
             L+  E +  T+T+  LK K+        + + +  E+++N +              LK
Sbjct: 191 DALS-LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE-------------LK 236

Query: 286 KLIHAAKLNASLKTLEGERNQIYIQLSEVDKT------KEELTEHIKNLQTE-----QAS 334
           + +  AKL    + L+ E + +  +L  V         + EL   +   Q E     +  
Sbjct: 237 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 296

Query: 335 LQSENTHFENENQKL---QQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEK 391
           +Q      + + +K+   ++K++   E+  E E K+ R    +E    EKEEK+ +++EK
Sbjct: 297 IQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR----QEEMMWEKEEKIRELEEK 352

Query: 392 ISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKE 451
           +    +  E   KR ++ +   +      + ++   E+K  +     R  E  + +  ++
Sbjct: 353 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412

Query: 452 NAHNRQKLTETELKFELLEK 471
                +K+ E E + +  E+
Sbjct: 413 MGEQEEKMWEQEEEMQEQEE 432



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 79/406 (19%), Positives = 166/406 (40%), Gaps = 65/406 (16%)

Query: 71  QKEYEGYEVESSLKDA-SFEKEATEAQSLEATCEK-LNRSNSELEDEILCLEKELKEEKS 128
           Q E E  ++ S L D+  F  E  +A S  AT +K  +R   EL  E   L  EL     
Sbjct: 143 QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTI 202

Query: 129 KHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKI-AIKDALNENS 187
              E  E  A + +++Q +E E   ++  V E K   +  ++   + ++ A  D L +  
Sbjct: 203 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 262

Query: 188 QLQESQKQL-LQEAEVWKEQVSELNKQKVTFEDSKVHA-EQVLNDKESHIKTLTERLLKM 245
           Q   ++ Q  ++E E+W  ++++  ++K+  ++ K+   E+ + ++E  I+   E++ + 
Sbjct: 263 QSVSAKLQAQVEENELWN-RLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQ 321

Query: 246 KDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERN 305
           +                  EM  E E                          + +  +  
Sbjct: 322 E------------------EMMWEKE--------------------------EKMRRQEE 337

Query: 306 QIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEM 365
            ++ +  ++ + +E++ E  K  + E+   + E    + + Q+ + K+    E  +E E 
Sbjct: 338 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 397

Query: 366 KLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQII 425
           K+      +E    E+EEK+ + +EK+    EE++   ++ +  EE++            
Sbjct: 398 KIRE----QEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR----------- 442

Query: 426 SHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEK 471
             EKK  +     R  E  + +  ++      K+ E E K +  E+
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEE 488



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 58/318 (18%), Positives = 144/318 (45%), Gaps = 33/318 (10%)

Query: 39  SRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSL 98
           +RL   +E+K+      + E + K+ E+   ++++ E    +   ++  +EKE       
Sbjct: 280 NRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQ---EEMMWEKE------- 329

Query: 99  EATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQV 158
               EK+ R    + ++    E++++E + K  EQ+++     KR Q  E   +  K Q 
Sbjct: 330 ----EKMRRQEEMMWEK----EEKIRELEEKMHEQEKIREQEEKR-QEEEKIREQEKRQE 380

Query: 159 AEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFE 218
            EAKM  +  ++ E+  KI       +   +QE ++++ ++ E   EQ  E+ +Q    E
Sbjct: 381 QEAKMWRQEEKIREQEEKIR-----EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQ----E 431

Query: 219 DSKVHAEQVLNDKESHIKTLTERLLK----MKDWAAMLGEDITDDDNLELEMNSESENGA 274
           +     E+ + ++E  I+   E++ +    M++    +GE        E +M  + E   
Sbjct: 432 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR 491

Query: 275 YLDNPPKGALKKL-IHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQA 333
             +   +   KK+     K+    + ++ +  +++ Q  ++ + +E++ E  + ++ ++ 
Sbjct: 492 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 551

Query: 334 SLQSENTHFENENQKLQQ 351
            ++ +      + +K+Q+
Sbjct: 552 KMREQEVRLRQQEEKMQE 569



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/194 (15%), Positives = 91/194 (46%), Gaps = 13/194 (6%)

Query: 30  LWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFE 89
           +WR    +R +     E+K+      + E++ K+ E+   + ++ E  + +        E
Sbjct: 385 MWRQEEKIREQ-----EEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439

Query: 90  KEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRI----Q 145
           K   + + +    EK+      ++++    E+++ E++ K  EQ+  M +  +++    +
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQ----EEKMGEQEGKMCEQEAKMQEQEEKMRRQEE 495

Query: 146 SLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKE 205
            + ++ K ++ Q  + +   ++ Q  EE++    +    +  ++QE ++++ ++ E  +E
Sbjct: 496 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMRE 555

Query: 206 QVSELNKQKVTFED 219
           Q   L +Q+   ++
Sbjct: 556 QEVRLRQQEEKMQE 569


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 109/461 (23%), Positives = 207/461 (44%), Gaps = 60/461 (13%)

Query: 57   IEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEI 116
            ++EK++LL+  S         +V   LKD +  +E  + QSLE   + L+ +  ELE++I
Sbjct: 2009 VKEKTELLQTLSS--------DVSELLKDKTHLQE--KLQSLEKDSQALSLTKCELENQI 2058

Query: 117  LCLEKE----LKEEKS---KHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQ 169
              L KE    +KE +S   + SE D    ++SK +++   E      +++  +      +
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118

Query: 170  MNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLN 229
               E+L++ I+    +   + E  K+  +E +  K++V  L ++    E+++        
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAE 2178

Query: 230  DKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIH 289
            + ++ ++TL  ++ +M     +   D+       + + SE EN        +G L +L  
Sbjct: 2179 NSKAEVETLKTQIEEMARSLKVFELDL-------VTLRSEKENLTKQIQEKQGQLSEL-- 2229

Query: 290  AAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEH-IKNLQTEQASL-----------QS 337
              KL +S K+L  E+ Q  IQ+ E  KT  E+ ++ +K L    A+L           QS
Sbjct: 2230 -DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2288

Query: 338  ENTHFENENQ------KLQQKL-----KVMTELYQENEMKLHRKLTVEENYRLEKEEKLS 386
             +   E E+Q      KL+ +L     K +  L Q  E + H  L       LE+E +++
Sbjct: 2289 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2348

Query: 387  KVDEKISHATEELETYRKRAKDLEEELERTIHSYQG-----QIISHEKKAHDNWLAARNA 441
            + +++  HA  E E  +   + L+ ++E    S +G       I  EK+   N L  +  
Sbjct: 2349 RTNQE--HAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL--QKE 2404

Query: 442  ERNLNDLRKENAHNRQKLTETEL-KFELLEKDPYALDVPNT 481
            +  +++L   N+     L E E  K ++ EK   A+++  T
Sbjct: 2405 QERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQT 2445



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 78/415 (18%), Positives = 190/415 (45%), Gaps = 38/415 (9%)

Query: 45   REKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEK 104
            +E+ L+  +  L  EK++LL+     +  Y    ++SS+     E E  + Q LE   E+
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNY--IVLQSSVNGLIQEVEDGK-QKLEKKDEE 2523

Query: 105  LNRSNSELEDEILCLEKELKEE------KSKHSEQDELMADISKRIQSLEDESKSLKSQV 158
            ++R  ++++D+   + K  + E      K ++ E   L  ++ ++IQ L+ ++ SL+  +
Sbjct: 2524 ISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTL 2583

Query: 159  AEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFE 218
               + ++K  +   E  K+     + + +++   + +L +E     ++ +EL +++++ E
Sbjct: 2584 EVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAEL-QEELSGE 2642

Query: 219  DSKVHAE-----QVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDN----------LE 263
             +++  E     + +   +  +K LT    ++K     + +D  + +           L 
Sbjct: 2643 KNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLR 2702

Query: 264  LEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTE 323
            L    +      LD   +  ++   +  KL +  + L  ++    +++  +  +KEEL  
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQK----LEIDLLKSSKEELNN 2758

Query: 324  HIK---NLQTEQASLQSENTHFEN----ENQKLQQKLKVMTELYQ--ENEMKLHRKLTVE 374
             +K    +  E    + +N  + N    EN++ Q K+K++ +  +  E E ++ +K   +
Sbjct: 2759 SLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQ 2818

Query: 375  ENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEK 429
                 EK++  + +D K+   T E++  ++  ++  +E +  +  Y   +ISHEK
Sbjct: 2819 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEK 2873



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 100/468 (21%), Positives = 200/468 (42%), Gaps = 71/468 (15%)

Query: 59   EKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILC 118
            E   L  K   + +   G E++     +  E    E Q  +    +L   NS  E+ +  
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE 2424

Query: 119  LEKELKEEKSKHSEQDELMA----DISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEER 174
             E+E  + K K S   E++     ++++R+ +L ++ ++ K++        +  ++ + +
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ 2484

Query: 175  LKIAIKDALNENSQLQESQKQLLQEAEVWKEQV----SELNKQKVTFED--------SKV 222
            L   + +A N    LQ S   L+QE E  K+++     E+++ K   +D        S+V
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV 2544

Query: 223  HAEQVL------------NDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSES 270
              E  L             + E  I+ L  +   ++D   +L     + +N ELE+ ++ 
Sbjct: 2545 EGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN-ELEL-TKM 2602

Query: 271  ENGAYLDNPPKGALK------KLIHAAKLNASL-KTLEGERN----QIYIQLSEVDKTKE 319
            +  ++++   K   K      ++   A+  A L + L GE+N    ++ + L E+  +K+
Sbjct: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2662

Query: 320  ELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQ---ENEMKLHRKLTVEEN 376
            +L    K L  E + L+        +  + + K++     YQ       K H+ L ++ N
Sbjct: 2663 QL----KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718

Query: 377  YRLEKE-----EKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKA 431
             + E E     EKL+  +E +S    E++  +   ++L   L+ T      QI+   KK 
Sbjct: 2719 KQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATT-----QILEELKKT 2773

Query: 432  HDNWLAARNAERNLNDLRKEN--AHNRQKL-----TETELKFELLEKD 472
              + L      + +N L+KEN  A  + KL      + E + E+L+K+
Sbjct: 2774 KMDNL------KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKE 2815



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 86/394 (21%), Positives = 166/394 (42%), Gaps = 66/394 (16%)

Query: 66   KFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKE 125
            + S ++ E    E E+   +A  E   TE   LE       + N   +  I+CLE+EL  
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLE-------KDNENKQKVIVCLEEELSV 1955

Query: 126  EKSKHSEQDELMADISKRIQSLEDESKSLKS----------------QVAEAKMTFKIFQ 169
              S+ ++    +  +SK+  +L+  S+ +K                 QVAEA++  K   
Sbjct: 1956 VTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL 2015

Query: 170  MNEERLKIAIKDALNENSQLQESQKQLLQEAEV-------WKEQVSELNKQKVTFEDSKV 222
            +  + L   + + L + + LQE  + L ++++         + Q+++LNK+K        
Sbjct: 2016 L--QTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK-------- 2065

Query: 223  HAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKG 282
              E ++ + ES    L+E   +  + +  L   + +     L ++S  E    L      
Sbjct: 2066 --ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR---- 2119

Query: 283  ALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTE-QAS------- 334
                     KL   ++  E ++  I  +L E ++  + L + ++NL+ E Q S       
Sbjct: 2120 ------GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELV 2173

Query: 335  -LQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYR---LEKEEKLSKVDE 390
             L +EN+  E E  K Q  ++ M    +  E+ L    + +EN      EK+ +LS++D+
Sbjct: 2174 ILDAENSKAEVETLKTQ--IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231

Query: 391  KISHATEELETYRKRAKDLEEELERTIHSYQGQI 424
             +S     LE   +    ++EE +  +   Q Q+
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 89/485 (18%), Positives = 188/485 (38%), Gaps = 83/485 (17%)

Query: 57  IEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEI 116
           I+E    L+K   ++KE +  + +    +A+ +K+  + ++ +     L R N  L +  
Sbjct: 20  IQELEGQLDK---LKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76

Query: 117 LCLEK-------ELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTF---- 165
             LEK       EL+ ++S+ + Q+  +    K+I+ LE E K  KS++  ++       
Sbjct: 77  ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136

Query: 166 ----------KIFQM-----------NEERLKIAIKDALNENSQLQESQKQLLQEAEVWK 204
                     KIF               E LK      + E  +L+   K L  +     
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196

Query: 205 EQVSELNKQKVTFEDSKVHAEQVLNDKE-SHIKTLTERLLKMKDWAAML--GEDITDDDN 261
              + +N + +    +         +K  SH+ + ++R    +D++A    GE       
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256

Query: 262 LELEMNSESENGAYLDNPPKGALKKLIHAA-------------KLNASLKTLEGERNQIY 308
             L++     N ++ DN     L   + A              +L    K ++G+ N+  
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ 316

Query: 309 IQLSEVDKTKEELTEHIKNL------------QTEQAS----------------LQSENT 340
               +++K K EL E  K L            Q +QAS                L  +  
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQ 376

Query: 341 HFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELE 400
           + E+    L+QK+K   + +QE   +  R     +   ++ + +L++  ++  +    L+
Sbjct: 377 NAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436

Query: 401 TYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKEN----AHNR 456
               +   ++++LE  +  ++ ++   E+    + +      R++ +++KEN    +H+ 
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496

Query: 457 QKLTE 461
           QK  E
Sbjct: 497 QKARE 501



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 96/431 (22%), Positives = 167/431 (38%), Gaps = 61/431 (14%)

Query: 48   KLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEAT----EAQSLEATCE 103
            K   M    + E S+ + K       ++    E+     + EKE      + ++ +A  +
Sbjct: 869  KAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQ 928

Query: 104  KLNRSNSELED---EILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAE 160
            +L +SN  LED   E+  L + L  EK    E   +++   + I+ L  E+ +LK   A 
Sbjct: 929  ELKKSNHLLEDSLKELQLLSETLSLEK---KEMSSIISLNKREIEELTQENGTLKEINAS 985

Query: 161  AKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQ----LLQEAEVWKEQVSELNKQKVT 216
                        E     I +     S+L +  KQ    LLQ  E       +L+++   
Sbjct: 986  LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKA 1045

Query: 217  FEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYL 276
             ++     E +LN+  S  +     L ++K+  A   ++                     
Sbjct: 1046 AQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF-------------------- 1085

Query: 277  DNPPKGALKKLIHAAKLNASLKTLEGERNQ-IYIQLSEVDKT-KEELTEHIKNLQTEQAS 334
                   L KL  A            ERNQ + ++L  V +  + E+T++  N ++E   
Sbjct: 1086 -------LTKLAFAE-----------ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGG 1127

Query: 335  LQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISH 394
            L+ E    + E  K+Q   K + +L QENE  +    T  E   LE E   + V E+ S 
Sbjct: 1128 LKQEIMTLKEEQNKMQ---KEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES- 1183

Query: 395  ATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAH 454
              E  +   K   DLE + E ++ SY  Q++  E    +  L  + +E+    L+ E   
Sbjct: 1184 --ERNQCNFKPQMDLEVK-EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1240

Query: 455  NRQKLTETELK 465
             R  L  + L+
Sbjct: 1241 IRGDLETSNLQ 1251



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 86/404 (21%), Positives = 169/404 (41%), Gaps = 44/404 (10%)

Query: 58  EEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEIL 117
           +E S  LEK  L   + E        +D S +        +E   +KL+++  E +  + 
Sbjct: 547 QENSLTLEKLKLAVADLE------KQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS 600

Query: 118 CLE------KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMN 171
            LE      +ELKEEK+  S      ++  K +  +E E ++L+S++   +   K  Q+ 
Sbjct: 601 ALELKKKEYEELKEEKTLFSCWK---SENEKLLTQMESEKENLQSKINHLETCLKTQQIK 657

Query: 172 E----ERLKIAIKDALNENSQLQESQKQLLQ---EAEVWKEQVSELNKQKVTFEDSKVHA 224
                ER++    D  N + +++     L     E E  K    EL +QK  F D K H 
Sbjct: 658 SHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMEL-QQKAEFSDQK-HQ 715

Query: 225 EQVLNDKESHIKT--LTERLLKMKDWAAMLGEDITDDDNLELEMNSESEN---------- 272
           +++ N     +KT  LT ++  ++    +L  +I D D    ++++E E+          
Sbjct: 716 KEIEN---MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772

Query: 273 GAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQ 332
               +   + +L        ++ S   + GE+  +  + SE     ++  ++   LQ   
Sbjct: 773 SLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV 832

Query: 333 ASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKI 392
            SL+      +  N  LQ++ + + ++  E E  L +   + +++  E  +++SK+ E  
Sbjct: 833 DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDT 892

Query: 393 SH----ATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAH 432
           S       E L     + K+L + L   + + Q +I   +K  H
Sbjct: 893 SAHQNVVAETLSALENKEKEL-QLLNDKVETEQAEIQELKKSNH 935



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 86/426 (20%), Positives = 184/426 (43%), Gaps = 61/426 (14%)

Query: 78   EVESSLKDASFEKEATEAQSLEATCEKLNRSNSELE---DEILCLEKELKEEKSKHSEQD 134
            E + S K+++  +   +  SLE + E   + NS+L+   +E++ ++ E++E   K  +  
Sbjct: 817  EADQSPKNSAILQNRVD--SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMH 874

Query: 135  E-LMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQ 193
            +  +A+ S+RI  L++++ + ++ VAE   T    +  E+ L++     LN+  + ++++
Sbjct: 875  QSFVAETSQRISKLQEDTSAHQNVVAE---TLSALENKEKELQL-----LNDKVETEQAE 926

Query: 194  KQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERL-LKMKDWAAML 252
                         + EL K     EDS              ++ L+E L L+ K+ ++++
Sbjct: 927  -------------IQELKKSNHLLEDSL-----------KELQLLSETLSLEKKEMSSII 962

Query: 253  GEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLS 312
              +  + + L  E  +  E  A L+      ++K       + S      ER +   +LS
Sbjct: 963  SLNKREIEELTQENGTLKEINASLNQEKMNLIQK-------SESFANYIDEREKSISELS 1015

Query: 313  EVDKTKEE---LTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHR 369
              D+ K+E   L +  +        L  +    + +N KL+  L   T L +  + +L +
Sbjct: 1016 --DQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ 1073

Query: 370  KLTVEENYRLEKEEKLSKV---DEKISHATEELETYRKRAKDLEEELERTIHSYQGQIIS 426
               ++E +  E +E L+K+   +E+  +   ELET ++  +    + +    S  G +  
Sbjct: 1074 ---LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130

Query: 427  HEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGRE 486
                  +        ++ +NDL +EN     K+ +T+ + + LE +P    V      R 
Sbjct: 1131 EIMTLKEE---QNKMQKEVNDLLQEN-EQLMKVMKTKHECQNLESEPIRNSVKERESERN 1186

Query: 487  HSPYGP 492
               + P
Sbjct: 1187 QCNFKP 1192



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 88/443 (19%), Positives = 175/443 (39%), Gaps = 54/443 (12%)

Query: 52  MLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSE 111
           +L  L  +  +L  K + ++   +G+E E   +   F++   + +  +    +  +  ++
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338

Query: 112 LEDEILCLEKELKEEKSKHSEQDE----LMADISKRIQSLEDESKSLKSQVAEAKMTFKI 167
             DE++    +  +  +K++  ++    L  D+S + Q+ E    SL+ ++ E +   K 
Sbjct: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE---KE 395

Query: 168 FQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQV 227
           FQ    R + + +    E  Q++    Q LQ+A+     V +    K+T          V
Sbjct: 396 FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKN-MHNVLQAELDKLT---------SV 445

Query: 228 LNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKL 287
               E++++   ++L + +   A     I +++ L   M    +    L +  +   +++
Sbjct: 446 KQQLENNLEEFKQKLCRAEQ--AFQASQIKENE-LRRSMEEMKKENNLLKSHSEQKAREV 502

Query: 288 IHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQ 347
            H   L A LK ++   NQ            +   E +K          ++NT  E   +
Sbjct: 503 CH---LEAELKNIKQCLNQ-----------SQNFAEEMK----------AKNTSQETMLR 538

Query: 348 KLQQKLKVMTELYQENEMKLHR-KLTVE--ENYRLEKEEKLSKVDEKISHATEELETYRK 404
            LQ+K+       QEN + L + KL V   E  R   ++ L K +  I    ++L    K
Sbjct: 539 DLQEKIN-----QQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEK 593

Query: 405 RAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETEL 464
            +K L   LE     Y+   +  EK     W +         +  KEN  ++    ET L
Sbjct: 594 ESKALLSALELKKKEYEE--LKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCL 651

Query: 465 KFELLEKDPYALDVPNTAFGREH 487
           K + ++   Y   V      RE+
Sbjct: 652 KTQQIKSHEYNERVRTLEMDREN 674



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 91/440 (20%), Positives = 171/440 (38%), Gaps = 41/440 (9%)

Query: 45   REKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEK 104
            REK ++ +     +EK  LL++       YE  ++    K A  +    E    E T   
Sbjct: 1007 REKSISELSDQYKQEKLILLQRCEETGNAYE--DLSQKYKAAQEKNSKLECLLNECTSLC 1064

Query: 105  LNRSNSELEDEILCLEKELKEEKSKHSEQDE----LMADISKRIQSLE----DESKSLKS 156
             NR N ELE       KE +E  +K +  +E    LM ++    Q+L     D   + KS
Sbjct: 1065 ENRKN-ELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKS 1123

Query: 157  QVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQ----EAEVWKEQVSELNK 212
            +    K      +  + +++  + D L EN QL +  K   +    E+E  +  V E   
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183

Query: 213  QKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESEN 272
            ++          +  L  KE  + +   +L++++   AML        N EL++  ESE 
Sbjct: 1184 ER---NQCNFKPQMDLEVKEISLDSYNAQLVQLE---AML-------RNKELKL-QESEK 1229

Query: 273  GAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQ 332
                    K  L+  +   + +     L+  ++Q    L + +   EE  ++I     E 
Sbjct: 1230 -------EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE--KYISG-PHEL 1279

Query: 333  ASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKI 392
            ++ Q++N H +   Q    KL  + ++ +  + + +  +T   + R E      K+ E++
Sbjct: 1280 STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEV 1339

Query: 393  SHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKEN 452
                 E++     +  L  EL   I    G+      + H   LA  +   +   L   +
Sbjct: 1340 GKLLNEVKILNDDSGLLHGELVEDIPG--GEFGEQPNEQHPVSLAPLDESNSYEHLTLSD 1397

Query: 453  AHNRQKLTETELKFELLEKD 472
               +    E + KF  L+ +
Sbjct: 1398 KEVQMHFAELQEKFLSLQSE 1417



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 102/467 (21%), Positives = 179/467 (38%), Gaps = 82/467 (17%)

Query: 81   SSLKDASFEK---EATEAQSLEATCEKLNRSNSELEDEILC--------LEKELKEEKSK 129
            SSL D+SF +   E T   SL +  E    +N    DE+ C          KE     +K
Sbjct: 1488 SSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAK 1547

Query: 130  HSEQDELMADISKRIQSLEDESKSLKSQVA----EAKMTFKIFQMNEERLKIAIKDALNE 185
              E+ E + ++ +  QSLE   + ++SQ      E +   ++     + L    K  L+E
Sbjct: 1548 GVEELESLCEVYR--QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSE 1605

Query: 186  NSQLQES------------------QKQLLQEAEVWKEQVSELNKQK-----VTFEDSKV 222
            N Q Q+                    +QL  E EV + Q+  L+        +  ED+  
Sbjct: 1606 NEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQ 1665

Query: 223  HAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSES-----------E 271
               +  +  + H    TER  K  D   +  +D   D NL++E  +E+           E
Sbjct: 1666 GRNESCDISKEHTSETTERTPK-HDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGE 1724

Query: 272  NGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTE 331
                 +  P G  K     +    S  +  G        L  +D    +  E I NLQ  
Sbjct: 1725 QSPDTNYEPPGEDKT--QGSSECISELSFSGPN-----ALVPMDFLGNQ--EDIHNLQLR 1775

Query: 332  QASLQSENTH----FENENQKLQQKLKVMTELYQENEMKLHRKLT-VEENYRLEK----- 381
                 +EN       E+ ++K++  L  M EL  +  ++  + +T +E    LEK     
Sbjct: 1776 VKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGEL 1835

Query: 382  EEKLSKVDEKISHAT-------EELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDN 434
            +++ S + EK+ + +       + +ET      DLE   +++     G  ++   K +D+
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVA---KVNDS 1892

Query: 435  WLAA-RNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPN 480
            W     + E  L+ +R E A    +    E   E+++ +   L+  N
Sbjct: 1893 WKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1939



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 39/147 (26%), Positives = 73/147 (49%), Gaps = 21/147 (14%)

Query: 280 PKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN 339
           P  AL+K+    +L   L  L+ E+ Q   QL  ++   ++  + ++N +TE        
Sbjct: 13  PTRALQKI---QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-------G 62

Query: 340 THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEEL 399
           T+ + ENQ+L +    + E  ++ + K+  +L V+E+    +E +L+   ++I    E+L
Sbjct: 63  TNLKRENQRLME----ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQI----EKL 114

Query: 400 ETYRKRAKDLEEELERTIHSYQGQIIS 426
           E   KR K    ELER+  + Q   +S
Sbjct: 115 EQELKRCK---SELERSQQAAQSADVS 138



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 72/383 (18%), Positives = 143/383 (37%), Gaps = 64/383 (16%)

Query: 111 ELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQM 170
           ELE +   L+K  KE++ +  + D L A + K+ Q +E+E     +   E +   +I + 
Sbjct: 22  ELEGQ---LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78

Query: 171 NEE-------RLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVH 223
            E+        L++       +  QL   +KQ+ +  +  K   SEL + +   + + V 
Sbjct: 79  LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVS 138

Query: 224 AEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGA 283
               LN   +  K  T  L   + ++    ED+ +  N E+E                  
Sbjct: 139 ----LNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE------------------ 176

Query: 284 LKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQA-----SLQSE 338
                   +L A +K L         Q  +  +T  + T + +++   QA     S Q E
Sbjct: 177 -----ERKRLEAEVKAL---------QAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222

Query: 339 NT--HFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKIS-HA 395
            T  H  + +Q+   +       +   +     + T++     +++   S  D   S H 
Sbjct: 223 KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIG---KRDANSSFFDNSSSPHL 279

Query: 396 TEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNA-------ERNLNDL 448
            ++L+   +  ++   ELE  +  ++ ++     K  +  L    A       E+ LN  
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339

Query: 449 RKENAHNRQKLTETELKFELLEK 471
           R E      +  +   K+  LE+
Sbjct: 340 RDELVRTTAQYDQASTKYTALEQ 362



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 68/330 (20%), Positives = 127/330 (38%), Gaps = 27/330 (8%)

Query: 75   EGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEE--KSKHSE 132
            E YE+ + L D+  E      +  E   + LN     L D+   L  EL E+    +  E
Sbjct: 1313 EKYELVTELNDSRSECITATRKMAEEVGKLLNEVKI-LNDDSGLLHGELVEDIPGGEFGE 1371

Query: 133  QDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQES 192
            Q      +S       +  + L     E +M F   Q     L+   K   +++ Q+   
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSK 1431

Query: 193  QKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAML 252
              +L    +  K +   L+     F+   V  E  L  +E  + +L+   +      + L
Sbjct: 1432 MSELQTYVDSLKAENLVLSTNLRNFQGDLVK-EMQLGLEEGLVPSLSSSCVPDSSSLSSL 1490

Query: 253  GED------ITDDDNLELEMNSE---SENGAYLDNPPKGALKK--LIHAAKLNASLKTLE 301
            G+       +    ++ L  N E   S N   +D     +L++  L      +A  K +E
Sbjct: 1491 GDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVE 1550

Query: 302  GERNQIYIQLSEVDKTKEELTEH--IKN---------LQTEQASLQSENTHFENENQKLQ 350
               +   +    ++K +E++     +KN         L +E+  L      + +EN++ Q
Sbjct: 1551 ELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQ 1610

Query: 351  QKLKVMTELYQENEMKLHRKLTVEENYRLE 380
            QKL  +T L  E+++   +K T + +  LE
Sbjct: 1611 QKLTSVT-LEMESKLAAEKKQTEQLSLELE 1639


>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
          Length = 976

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 88/427 (20%), Positives = 194/427 (45%), Gaps = 44/427 (10%)

Query: 45  REKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEK 104
           +EK+++L+L  + E+++K+ +   L++   E  +  + L+    EK   ++++L+ + EK
Sbjct: 264 KEKQVSLLLIQITEKENKMKDLTFLLE---ESRDKVNQLE----EKTKLQSENLKQSIEK 316

Query: 105 LNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMT 164
            +    ELED  + L++ +  +K+   E+D  +A  +    + E E++  +S  A A  +
Sbjct: 317 QHHLTKELEDIKVSLQRSVSTQKAL--EEDLQIATKTICQLTEEKETQMEESNKARAAHS 374

Query: 165 FKI--------------------FQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWK 204
           F +                     + NE++LKI   +   ++S+L+E  K L    EV  
Sbjct: 375 FVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTK-LTNNKEVEL 433

Query: 205 EQVSEL--NKQKVTFEDSKVH--AEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDD 260
           E++ ++   K+ + +E+ +    AE++   ++  I  L  R  ++ D    L    T + 
Sbjct: 434 EELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQ 493

Query: 261 NLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVD----- 315
               E+         L+N      +   H  KL+   K L  E + + ++L         
Sbjct: 494 YYSKEVKDLKTE---LENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN 550

Query: 316 --KTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTV 373
             K +E + + I+NLQ  +  L++E  +   E ++ + ++K   +  +EN   L +++  
Sbjct: 551 NKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVEN 610

Query: 374 EENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHD 433
           +  Y  E +++   + +K +  +++L  Y  +   LE ELE     +     +++K+  D
Sbjct: 611 KNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIED 670

Query: 434 NWLAARN 440
             ++  N
Sbjct: 671 KKISEEN 677



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 91/427 (21%), Positives = 184/427 (43%), Gaps = 36/427 (8%)

Query: 57  IEEKSKLLEKFSLVQ-------KEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSN 109
           +E   KL E +  +Q       KE    E + SL      ++  + + L    E+     
Sbjct: 237 LEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKV 296

Query: 110 SELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQ 169
           ++LE++     + LK+   K     + + DI   +Q      K+L+  +  A  T  I Q
Sbjct: 297 NQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKT--ICQ 354

Query: 170 MNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLN 229
           + EE+            +Q++ES K     + V    V+E      + E+     +Q L 
Sbjct: 355 LTEEK-----------ETQMEESNKARAAHSFV----VTEFETTVCSLEELLRTEQQRLE 399

Query: 230 DKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELE----MNSESENGAYLDNPPKGALK 285
             E  +K LT  L K       + + +T++  +ELE    +  E E   Y +   +   +
Sbjct: 400 KNEDQLKILTMELQKKSSELEEMTK-LTNNKEVELEELKKVLGEKETLLYENKQFEKIAE 458

Query: 286 KLIHA-AKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFEN 344
           +L     +L   L+  E E + + IQL+ +  +++  ++ +K+L+TE  + + +NT   +
Sbjct: 459 ELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518

Query: 345 ENQKLQQKLKVMTELYQENEMKLHRKLTVEE-NYRLEKEEKLSKVDEKISHATEELETYR 403
              KL  + K +T+  + ++M L  K   E+ N   ++EE++ K  E +     +L   R
Sbjct: 519 HCNKLSLENKELTQ--ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQL---R 573

Query: 404 KRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETE 463
              + + EEL++     + ++   E+  ++      N  + + +L++EN   ++K T   
Sbjct: 574 NELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAES 633

Query: 464 LKFELLE 470
            +  + E
Sbjct: 634 KQLNVYE 640



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 88/400 (22%), Positives = 164/400 (41%), Gaps = 42/400 (10%)

Query: 13  ELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQK 72
           EL     V+G    L +  + F  +   L  G E++L  +L    +E   L  + + +  
Sbjct: 432 ELEELKKVLGEKETLLYENKQFEKIAEELK-GTEQELIGLLQAREKEVHDLEIQLTAITT 490

Query: 73  EYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELK---EEKSK 129
             + Y  E        E E  +   L + C KL+  N EL  E   +  ELK   E+ + 
Sbjct: 491 SEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN 550

Query: 130 HSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFK--------IFQMNEERLKIAIKD 181
           + +Q+E M    K+I++L++    L++++   +   K            +EE      K 
Sbjct: 551 NKKQEERML---KQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607

Query: 182 ALNEN---SQLQESQKQLLQEAEVWKEQVS----ELNKQKVTFEDSKVHAEQVLNDKESH 234
             N+N    +LQ+  K L ++     +Q++    ++NK ++  E +K    ++ +  +  
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667

Query: 235 I---KTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENG----AYLDNPPKGALKKL 287
           I   K   E LL+  + A ++ ++      L+ E++   ++       L    K    K+
Sbjct: 668 IEDKKISEENLLEEVEKAKVIADEAV---KLQKEIDKRCQHKIAEMVALMEKHKHQYDKI 724

Query: 288 IHAAKLNASL-KTLEGERNQIYIQLS-EVDKTKEELTEHIKNLQTEQASLQ------SEN 339
           I        L K+ E E++ +   L  E+   K EL    K L+ E+   +       EN
Sbjct: 725 IEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKEN 784

Query: 340 THF--ENENQKLQQKLKVMTELYQENEMKLHRKLTVEENY 377
           T    E +++K Q  L    E+Y + + K     TV  N+
Sbjct: 785 TATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNF 824



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 65/267 (24%), Positives = 117/267 (43%), Gaps = 44/267 (16%)

Query: 159 AEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFE 218
           AE    +K+    E R K   +  L EN ++ E+Q++ +QE +   E+VS L  ++   E
Sbjct: 113 AEKIKKWKVSTEAELRQK---ESKLQENRKIIEAQRKAIQELQFGNEKVS-LKLEEGIQE 168

Query: 219 DSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDN 278
           +  +  E   N+   H+  L      +K+  A   E        + E   E     Y+D 
Sbjct: 169 NKDLIKE---NNATRHLCNL------LKETCARSAE-----KTKKYEYEREETRQVYMD- 213

Query: 279 PPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSE----VDKTKEELTEHIKNLQTEQAS 334
                ++K+I A          E  R +++ +L E    +   ++E  + I + + + + 
Sbjct: 214 -LNNNIEKMITA--FEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSL 270

Query: 335 LQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISH 394
           L  + T  EN       K+K +T L +E+  K+++   +EE  +L+  E L +  EK  H
Sbjct: 271 LLIQITEKEN-------KMKDLTFLLEESRDKVNQ---LEEKTKLQ-SENLKQSIEKQHH 319

Query: 395 ATEELETYR-------KRAKDLEEELE 414
            T+ELE  +          K LEE+L+
Sbjct: 320 LTKELEDIKVSLQRSVSTQKALEEDLQ 346



 Score = 38.1 bits (87), Expect = 0.031
 Identities = 40/181 (22%), Positives = 78/181 (43%), Gaps = 24/181 (13%)

Query: 312 SEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLH--- 368
           +E+ + + +L E+ K ++ ++ ++Q      E  + KL++ ++   +L +EN    H   
Sbjct: 125 AELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCN 184

Query: 369 -------RKLTVEENYRLEKEE------KLSKVDEKISHATEELETYRKRAK-----DLE 410
                  R     + Y  E+EE       L+   EK+  A EEL    + ++      L+
Sbjct: 185 LLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLK 244

Query: 411 EELERTIH---SYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFE 467
           E+ E+  H    Y+ +I   EK+     +     E  + DL      +R K+ + E K +
Sbjct: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304

Query: 468 L 468
           L
Sbjct: 305 L 305


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 90/444 (20%), Positives = 180/444 (40%), Gaps = 67/444 (15%)

Query: 46   EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEV----ESSLKDASFEKEATEAQSLEAT 101
            EK++A M     + K +L  K    +KE E   V    E +      + EA      E  
Sbjct: 850  EKEMANMKEEFEKTKEELA-KTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEER 908

Query: 102  CEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEA 161
            C++L ++  +LE +I       KE   +  +++E+ A+++ + + LEDE   LK  + + 
Sbjct: 909  CDQLIKTKIQLEAKI-------KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961

Query: 162  KMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK 221
            ++T    +  +   +  +K+   E + L E+              +++L K+K   +++ 
Sbjct: 962  ELTLAKVEKEKHATENKVKNLTEEMAGLDET--------------IAKLTKEKKALQEAH 1007

Query: 222  VHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPK 281
                  L  +E  + TLT+  +K+        E   DD    LE + E E    +D    
Sbjct: 1008 QQTLDDLQAEEDKVNTLTKAKIKL--------EQQVDD----LEGSLEQEKKIRMD---- 1051

Query: 282  GALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTH 341
                       L  + + LEG+         +++  K++L E +K  + E + LQS+   
Sbjct: 1052 -----------LERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIED 1100

Query: 342  FENENQKLQQKLKVMTELYQENEMKLHRKLTVE---ENYRLEKEEKLSKVDEKISHATEE 398
             +    +LQ+K+K +    +E E ++  +       E  R +   +L ++ E++  A   
Sbjct: 1101 EQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1160

Query: 399  LETYRKRAKDLEEELERTIHSYQGQIISHE------KKAHDNWLA-----ARNAERNLND 447
                 +  K  E E ++     +   + HE      +K H + +A       N +R    
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK 1220

Query: 448  LRKENAHNRQKLTETELKFELLEK 471
            L KE +  + ++ +     E + K
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSK 1244



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 98/437 (22%), Positives = 189/437 (43%), Gaps = 56/437 (12%)

Query: 53   LSGLIEEKSKLLEKFSLVQK--EYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNS 110
            L+  I E  K + +   ++K  E E  E++++L++A    E  E + L    E LN+  S
Sbjct: 1516 LTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE-LNQVKS 1574

Query: 111  ELEDEILCLEKELKEEKSKH-----SEQDELMADISKR-------------IQSLEDESK 152
            E++ +I   ++E+ + K  H     S Q  L A+I  R             +  +E +  
Sbjct: 1575 EVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1634

Query: 153  SLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNK 212
                  AEA   ++  Q   +  ++ + DAL     L+E    + + A + + ++ EL  
Sbjct: 1635 HANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1694

Query: 213  QKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESEN 272
                 E S+  AEQ L D    ++ L  +   + +    L  DI+       ++  E+ N
Sbjct: 1695 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARN 1754

Query: 273  GAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQ--- 329
                    + A K +  AA +   LK  +          + +++ K+ L + +K+LQ   
Sbjct: 1755 AE------EKAKKAITDAAMMAEELKKEQDTS-------AHLERMKKNLEQTVKDLQHRL 1801

Query: 330  --TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSK 387
               EQ +L+      + + QKL+ +++ +     E E++  +K  VE    L K E+  K
Sbjct: 1802 DEAEQLALKGG----KKQIQKLEARVREL-----EGEVESEQKRNVEAVKGLRKHERKVK 1852

Query: 388  VDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLND 447
               ++++ TEE      R +DL ++L+  + SY+ Q    E++++ N    R  +  L  
Sbjct: 1853 ---ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHEL-- 1907

Query: 448  LRKENAHNRQKLTETEL 464
               E A  R  + E+++
Sbjct: 1908 ---EEAEERADIAESQV 1921



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 89/442 (20%), Positives = 177/442 (40%), Gaps = 53/442 (11%)

Query: 56   LIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDE 115
            L E K KL ++    ++  E    + +  + + ++   E + L    E+ N + + L+ +
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK 1449

Query: 116  ILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERL 175
                +K L E K K  E           +++ + ES+SL +++      FKI    EE L
Sbjct: 1450 QRNFDKILAEWKQKCEE-------THAELEASQKESRSLSTEL------FKIKNAYEESL 1496

Query: 176  KIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHI 235
               ++    EN  LQ+    L ++     +++ EL K K   E  K   +  L + E+ +
Sbjct: 1497 D-QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASL 1555

Query: 236  KTLTERLLK----MKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAA 291
            +    ++L+    +    + +   I + D    E++    N   +    +  L   I + 
Sbjct: 1556 EHEEGKILRIQLELNQVKSEVDRKIAEKDE---EIDQMKRNHIRIVESMQSTLDAEIRSR 1612

Query: 292  KLNASL-KTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFEN---ENQ 347
                 L K +EG+ N++ IQL+  ++      E ++N +  QA L+    H ++     +
Sbjct: 1613 NDAIRLKKKMEGDLNEMEIQLNHANRM---AAEALRNYRNTQAILKDTQLHLDDALRSQE 1669

Query: 348  KLQQKLKVM---TELYQENEMKLHRKLTVEENYRLEKEEKL------------------- 385
             L+++L ++     L Q    +L   L   E  R   E++L                   
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1729

Query: 386  --SKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAER 443
               K++  IS    E+E   + A++ EE+ ++ I +    +    KK  D        ++
Sbjct: 1730 TKKKLETDISQIQGEMEDIIQEARNAEEKAKKAI-TDAAMMAEELKKEQDTSAHLERMKK 1788

Query: 444  NLNDLRKENAHNRQKLTETELK 465
            NL    K+  H   +  +  LK
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALK 1810



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 79/400 (19%), Positives = 174/400 (43%), Gaps = 54/400 (13%)

Query: 53   LSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSEL 112
            +  L EE + L E  + + KE      + +L++A  ++   + Q+ E     L ++  +L
Sbjct: 979  VKNLTEEMAGLDETIAKLTKE------KKALQEAH-QQTLDDLQAEEDKVNTLTKAKIKL 1031

Query: 113  EDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKS--QVAEAKMTFKIFQM 170
            E ++  LE  L++EK    + +     +   ++  ++ +  +++  Q  + K+  K F+M
Sbjct: 1032 EQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEM 1091

Query: 171  NEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLND 230
            +  + KI  + AL    QLQ+  K+L       + ++ EL ++      S+  AE+  +D
Sbjct: 1092 SGLQSKIEDEQALG--MQLQKKIKEL-------QARIEELEEEIEAERASRAKAEKQRSD 1142

Query: 231  KESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESE----------NGAYLDNPP 280
                ++ ++ERL           E+     + ++EMN + E            A L +  
Sbjct: 1143 LSRELEEISERL-----------EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191

Query: 281  KGALKKLIHA---AKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQS 337
              A  +  HA   A+L   +  L+  + ++       +K K E+   I +L +   ++  
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKL-------EKEKSEMKMEIDDLASNMETVSK 1244

Query: 338  ENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEE-NYRLEKEEKLSKVDEK---IS 393
               + E   + L+ +L  + +  +E + +L   LT +    + E  E   ++DEK   +S
Sbjct: 1245 AKGNLEKMCRALEDQLSEI-KTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS 1303

Query: 394  HATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHD 433
              +   + + ++ ++L+ +LE  I +      + +   HD
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHD 1343



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 80/421 (19%), Positives = 170/421 (40%), Gaps = 33/421 (7%)

Query: 46   EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKL 105
            EK    +   L E K+K  E+  L+  +          +   + ++  E  +L +   +L
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLIN-DLTAQRARLQTESGEYSRQLDEKDTLVS---QL 1305

Query: 106  NRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTF 165
            +R       +I  L+++L+EE    S     +         L ++ +  + Q A+A++  
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE--EEQEAKAELQR 1363

Query: 166  KIFQMNEERLKIAIK---DALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKV 222
             + + N E  +   K   DA+    +L+E++K+L Q  +  +E V  +N +  + E +K 
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423

Query: 223  HAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSE-SENGAYLDNPPK 281
              +  + D    ++       +     A L +   + D +  E   +  E  A L+   K
Sbjct: 1424 RLQNEVEDLMIDVE-------RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1476

Query: 282  GALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTH 341
                    +  L+  L  ++    +   QL  + +  + L + I +L TEQ +   +  H
Sbjct: 1477 -------ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL-TEQIAEGGKRIH 1528

Query: 342  -FENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELE 400
              E   ++++Q+   +    +E E  L  +       +LE  +  S+VD KI+   EE++
Sbjct: 1529 ELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1588

Query: 401  TYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLT 460
                    ++    R + S Q  + +  +  +D     +  E +LN++  +  H  +   
Sbjct: 1589 -------QMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1641

Query: 461  E 461
            E
Sbjct: 1642 E 1642



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 43/200 (21%), Positives = 81/200 (40%), Gaps = 43/200 (21%)

Query: 54   SGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELE 113
            + LI  K KL    S +Q E E    E+   +   +K  T+A  +    +K   +++ LE
Sbjct: 1725 TSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784

Query: 114  DEILCLEKELKEEKSKHSEQDEL-MADISKRIQSLEDESKSLKSQVA------------- 159
                 LE+ +K+ + +  E ++L +    K+IQ LE   + L+ +V              
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL 1844

Query: 160  ---EAKMTFKIFQMNEERLKIA-IKDALNENSQLQESQKQLLQEAE-------------- 201
               E K+    +Q  E+R  I  ++D +++     +S K+  +EAE              
Sbjct: 1845 RKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQ 1904

Query: 202  -----------VWKEQVSEL 210
                       + + QV++L
Sbjct: 1905 HELEEAEERADIAESQVNKL 1924


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 95/482 (19%), Positives = 204/482 (42%), Gaps = 60/482 (12%)

Query: 45  REKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEK 104
           +EK+L      L E++ +L E+  L ++E +  E E        EK   + + +    EK
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQE--------EKMWEQEEKMREQEEK 332

Query: 105 LNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSL-KSQVAEAKM 163
           + R    L ++    EK+++E++ K  +Q+E M +  +R++  E+  +   K    E KM
Sbjct: 333 MWRQEERLWEQ----EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKM 388

Query: 164 TFKIFQMNEERLKIAIKDALNENSQLQESQKQLL-QEAEVWKEQVSELNKQKVTFEDSKV 222
                   EER++   K    E   ++E ++++  QE  +W+++  E  +Q++  +  K+
Sbjct: 389 ------QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442

Query: 223 HAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKG 282
             ++ + ++E  I    E   K++D   M G++         E   E E+  +       
Sbjct: 443 WEQEKMQEQEEKIWEQEE---KIRDQEEMWGQE---KKMWRQEKMREQEDQMWEQEE--- 493

Query: 283 ALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHF 342
                    K+    + +  +  +++ Q   + + +E + E  K  Q E+   + + T  
Sbjct: 494 ---------KMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ- 543

Query: 343 ENENQKLQQKLKVMTE---------LYQENEM--KLHRKLTVEENYRLEKEEKLSKVDEK 391
           E E +   Q+ K+  E         + +E EM  +   K+  +E    E+EEK+ + +EK
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK 603

Query: 392 ISHATEEL-----ETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLN 446
           +    E++     + + +  +D  +E E  +   + ++   E+K  +     R  E  + 
Sbjct: 604 MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMR 663

Query: 447 DLRKENAHNRQKLTETELKFE-----LLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSE 501
           +  ++     +K+ E E K +     + E++          +G+E   +G     W   E
Sbjct: 664 EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 723

Query: 502 TR 503
            R
Sbjct: 724 MR 725



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 96/444 (21%), Positives = 198/444 (44%), Gaps = 35/444 (7%)

Query: 47  KKLALMLSGLIEEKSKL---LEKFSLVQKEYEGYEVESSLKDASFEKEATEAQ-SLEATC 102
           KK    +  L +E+  L   L + ++  +E +    E   K    E E +E Q +++   
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214

Query: 103 EKLNRSN--------SELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSL 154
            KL R+         + L++E+   E+EL+E++ K  +Q+E M    +R++  E E K +
Sbjct: 215 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR--EQEGK-M 271

Query: 155 KSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQK 214
           + Q  + +   K  +  E+ L+   K+ L E  +L+E ++Q+ ++ E   EQ  ++ +Q 
Sbjct: 272 REQEEKMRRQEKRLREQEKELREQEKE-LREQKKLREQEEQMQEQEEKMWEQEEKMREQ- 329

Query: 215 VTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGA 274
              E+     E+ L ++E   K + E+  KM+D    + E    D+ L  +     E   
Sbjct: 330 ---EEKMWRQEERLWEQE---KQMREQEQKMRDQEERMWEQ---DERLREKEERMREQEK 380

Query: 275 YLDNPPKGALKKLIHAA--KLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQ 332
             +   K   ++ I     K+    +T+  +  ++  Q  E +  ++E  E  +    EQ
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKM--QKQEENMWEQEEKEWQQQRLPEQ 438

Query: 333 ASLQSENTHFENENQKL---QQKLKVMTELY-QENEMKLHRKLTVEENYRLEKEEKLSKV 388
                E    + + +K+   ++K++   E++ QE +M    K+  +E+   E+EEK+   
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498

Query: 389 DEKISHATEELETYRKRAKDLEEEL-ERTIHSYQGQIISHEKKAHDNWLAARNAERNLND 447
           ++K+    E +    +R ++ EE + E+     Q + +  EKK  +      + E  + +
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMRE 558

Query: 448 LRKENAHNRQKLTETELKFELLEK 471
             +     ++   E E+  E  EK
Sbjct: 559 EERMREREKKMREEEEMMREQEEK 582



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 77/424 (18%), Positives = 184/424 (43%), Gaps = 58/424 (13%)

Query: 30  LWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFE 89
           LW   + +R +     E+K+      + E+  +L EK   ++++ + +E E  +++    
Sbjct: 340 LWEQEKQMREQ-----EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERI 394

Query: 90  KEAT-----EAQSLEATCEKLNRSNS--------ELEDEILCLEKELKEEKSKHSEQDEL 136
           +E       E +++    EK+ +           E + + L  +KE   E+ K  EQ+E 
Sbjct: 395 REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454

Query: 137 MADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDAL---------NENS 187
           + +  ++I+  E+     K    + KM  +  QM E+  K+  ++            ++ 
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514

Query: 188 QLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKD 247
           +L+E ++++ ++ ++W+++  ++ ++K T E  K   +Q   +K    + + ER  KM++
Sbjct: 515 RLREKEERMREQKKMWQQE-EKMREEKKTQEQEKKTWDQ--EEKMREEERMREREKKMRE 571

Query: 248 WAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQI 307
              M+ E        E +M  + E                    K+    + ++ +  ++
Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEE--------------------KMWEQEEKMQEQEEKM 611

Query: 308 YIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMK- 366
           + Q  ++ + +EE       +Q ++  +  +    + + +K+ ++ + M E  QE +M+ 
Sbjct: 612 WEQEEKMWEQEEE-----DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMRE--QEEKMRE 664

Query: 367 LHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIIS 426
              K+  +E    E+EEK+   +EK+    E++    ++    EE++        GQ   
Sbjct: 665 QEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEM 724

Query: 427 HEKK 430
            EK+
Sbjct: 725 REKE 728



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 66/373 (17%), Positives = 154/373 (41%), Gaps = 40/373 (10%)

Query: 106 NRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKR---IQSLEDESKSLKSQVAEAK 162
           N +N E      C   E  E+K+ H  Q+ L  +I  +   I+ L  +   L++ +  ++
Sbjct: 54  NGTNPETTTSEGCHSPE-DEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQ 112

Query: 163 MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQ----VSELNKQKVTFE 218
              + F+         +   L+ +       ++ L     W ++    + EL K++    
Sbjct: 113 DAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALS 172

Query: 219 DSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDN 278
                        E +  T+T   LK K+        + + +  E+++N +      L  
Sbjct: 173 ------------LELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKE-----LKR 215

Query: 279 PPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSE 338
             + A K L+   + N   + +  +  ++  Q  ++ K +E++    + L+ ++  ++ +
Sbjct: 216 KLERA-KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 274

Query: 339 NTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEE 398
                 + ++L+++ K + E  QE E++  +KL  +E    E+EEK+ + +EK+    E+
Sbjct: 275 EEKMRRQEKRLREQEKELRE--QEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332

Query: 399 LETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQK 458
           +    +R  + E+++              E+K  D        +  L + ++E    ++K
Sbjct: 333 MWRQEERLWEQEKQMR-----------EQEQKMRDQEERMWEQDERLRE-KEERMREQEK 380

Query: 459 LTETELKFELLEK 471
           + E E K +  E+
Sbjct: 381 MWEQEEKMQEEER 393


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 91/443 (20%), Positives = 185/443 (41%), Gaps = 65/443 (14%)

Query: 46   EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKL 105
            EK++A M     EE  K+  K  L + E +  E+E  +     EK   + Q ++A  E L
Sbjct: 852  EKEMATMK----EEFQKI--KDELAKSEAKRKELEEKMVTLLKEKNDLQLQ-VQAEAEGL 904

Query: 106  NRSNSELEDEI---LCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAK 162
              +    +  I   + LE ++KE   +  +++E+ A+++ + + LEDE   LK  + + +
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 163  MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKV 222
            +T    +  +   +  +K+   E + L E+              +++L K+K   +++  
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDET--------------IAKLTKEKKALQEAHQ 1010

Query: 223  HAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKG 282
                 L  +E  + TLT+  +K+        E   DD    LE + E E    +D     
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKL--------EQQVDD----LEGSLEQEKKLRMD----- 1053

Query: 283  ALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHF 342
                      L  + + LEG+       + +++  K++L E +K  + E ++LQS+    
Sbjct: 1054 ----------LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103

Query: 343  ENENQKLQQKLKVMTELYQENEMKLHRKLTVE---ENYRLEKEEKLSKVDEKISHATEEL 399
            +    +LQ+K+K +    +E E ++  +       E  R +   +L ++ E++  A    
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163

Query: 400  ETYRKRAKDLEEELERTIHSYQGQIISHE------KKAHDNWLA-----ARNAERNLNDL 448
                +  K  E E ++     +   + HE      +K H + +A       N +R    L
Sbjct: 1164 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223

Query: 449  RKENAHNRQKLTETELKFELLEK 471
             KE +  + ++ +     E + K
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSK 1246



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 97/437 (22%), Positives = 188/437 (43%), Gaps = 56/437 (12%)

Query: 53   LSGLIEEKSKLLEKFSLVQK--EYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNS 110
            L+  I E  K + +   ++K  E E  E++++L++A    E  E + L    E LN+  S
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE-LNQVKS 1576

Query: 111  ELEDEILCLEKELKEEKSKH-----SEQDELMADISKR-------------IQSLEDESK 152
            E++ +I   ++E+ + K  H     S Q  L A+I  R             +  +E +  
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636

Query: 153  SLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNK 212
                  AEA   ++  Q   +  +I + DAL     L+E    + + A + + ++ EL  
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696

Query: 213  QKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESEN 272
                 E S+  AEQ L D    ++ L  +   + +    L  DI+       ++  E+ N
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

Query: 273  GAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQ--- 329
                    + A K +  AA +   LK  +          + +++ K+ + + +K+LQ   
Sbjct: 1757 A------EEKAKKAITDAAMMAEELKKEQDTS-------AHLERMKKNMEQTVKDLQLRL 1803

Query: 330  --TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSK 387
               EQ +L+      + + QKL+ +++ +     E E++  +K   E    L K E+  K
Sbjct: 1804 DEAEQLALKGG----KKQIQKLEARVREL-----EGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 388  VDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLND 447
               ++++ TEE      R +DL ++L+  + SY+ Q    E++++ N    R  +  L  
Sbjct: 1855 ---ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL-- 1909

Query: 448  LRKENAHNRQKLTETEL 464
               E A  R  + E+++
Sbjct: 1910 ---EEAEERADIAESQV 1923



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 85/434 (19%), Positives = 168/434 (38%), Gaps = 74/434 (17%)

Query: 89   EKEATEAQ----SLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRI 144
            EKE +E +     L +  E ++++   LE     LE +L E KSK  EQ  L+ D++ + 
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283

Query: 145  QSLE----------DESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQK 194
              L+          DE ++L SQ++  K  F       E LK  +++ +   + L  + +
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFT---QQIEELKRQLEEEIKAKNALAHALQ 1340

Query: 195  QLLQEAEVWKEQVSELNKQKVTF-----------------------------EDSKVHAE 225
                + ++ +EQ  E  + K                                E++K    
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400

Query: 226  QVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALK 285
            Q L   E H++ +  +   ++     L  ++ D   L L++   +   A LD   +   K
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED---LMLDVERTNAACAALDKKQRNFDK 1457

Query: 286  KLIH----AAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENT- 340
             L        + +A L+  + E   +  +L ++    EE  + ++ L+ E  +LQ E + 
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517

Query: 341  -------------HFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSK 387
                           E   ++++Q+   +    +E E  L  +       +LE  +  S+
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577

Query: 388  VDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLND 447
            VD KI+   EE++        L+    R + S Q  + +  +  +D     +  E +LN+
Sbjct: 1578 VDRKIAEKDEEID-------QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630

Query: 448  LRKENAHNRQKLTE 461
            +  +  H  +   E
Sbjct: 1631 MEIQLNHANRMAAE 1644



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 79/415 (19%), Positives = 162/415 (39%), Gaps = 21/415 (5%)

Query: 54   SGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKE-ATEAQSLEATCEKLNRSNSEL 112
            S  IE   K   +F  ++++ E   ++     A+  K+ A     L    + L R   +L
Sbjct: 1164 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223

Query: 113  EDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNE 172
            E E   ++ E+ +  S      +   ++ K  ++LED+   LKS+  E +          
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283

Query: 173  ERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE 232
             RL+    +   +  + +    QL +  + + +Q+ EL +Q      +K      L    
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR 1343

Query: 233  SHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAK 292
                 L E+  + ++  A L   ++  +    +  ++ E  A          KK     K
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK-----K 1398

Query: 293  LNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQK 352
            L   L+  E     +  + + ++KTK+ L   +++L  +   ++  N      ++K +  
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD---VERTNAACAALDKKQRNF 1455

Query: 353  LKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEE 412
             K++ E  Q+ E + H +L   +        +L K+      + ++LET ++  K+L++E
Sbjct: 1456 DKILAEWKQKCE-ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514

Query: 413  LERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFE 467
                I     QI    K+ H+        E+    + +E    +  L E E   E
Sbjct: 1515 ----ISDLTEQIAEGGKRIHE-------LEKIKKQVEQEKCELQAALEEAEASLE 1558



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 28/139 (20%), Positives = 66/139 (47%), Gaps = 11/139 (7%)

Query: 79   VESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMA 138
            +E ++KD     +  E  +L+   +++ +    LE  +  LE E++ E+ +++E  + + 
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQK----LEARVRELEGEVESEQKRNAEAVKGLR 1847

Query: 139  DISKRIQSL-----EDESKSLKSQVAEAKMTFKI--FQMNEERLKIAIKDALNENSQLQE 191
               +R++ L     ED    L+ Q    K+  K+  ++   E  +      L +  +LQ 
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907

Query: 192  SQKQLLQEAEVWKEQVSEL 210
              ++  + A++ + QV++L
Sbjct: 1908 ELEEAEERADIAESQVNKL 1926


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 91/443 (20%), Positives = 185/443 (41%), Gaps = 65/443 (14%)

Query: 46   EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKL 105
            EK++A M     EE  K+  K  L + E +  E+E  +     EK   + Q ++A  E L
Sbjct: 852  EKEMATMK----EEFQKI--KDELAKSEAKRKELEEKMVTLLKEKNDLQLQ-VQAEAEGL 904

Query: 106  NRSNSELEDEI---LCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAK 162
              +    +  I   + LE ++KE   +  +++E+ A+++ + + LEDE   LK  + + +
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 163  MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKV 222
            +T    +  +   +  +K+   E + L E+              +++L K+K   +++  
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDET--------------IAKLTKEKKALQEAHQ 1010

Query: 223  HAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKG 282
                 L  +E  + TLT+  +K+        E   DD    LE + E E    +D     
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKL--------EQQVDD----LEGSLEQEKKLRMD----- 1053

Query: 283  ALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHF 342
                      L  + + LEG+       + +++  K++L E +K  + E ++LQS+    
Sbjct: 1054 ----------LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103

Query: 343  ENENQKLQQKLKVMTELYQENEMKLHRKLTVE---ENYRLEKEEKLSKVDEKISHATEEL 399
            +    +LQ+K+K +    +E E ++  +       E  R +   +L ++ E++  A    
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163

Query: 400  ETYRKRAKDLEEELERTIHSYQGQIISHE------KKAHDNWLA-----ARNAERNLNDL 448
                +  K  E E ++     +   + HE      +K H + +A       N +R    L
Sbjct: 1164 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223

Query: 449  RKENAHNRQKLTETELKFELLEK 471
             KE +  + ++ +     E + K
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSK 1246



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 97/437 (22%), Positives = 188/437 (43%), Gaps = 56/437 (12%)

Query: 53   LSGLIEEKSKLLEKFSLVQK--EYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNS 110
            L+  I E  K + +   ++K  E E  E++++L++A    E  E + L    E LN+  S
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE-LNQVKS 1576

Query: 111  ELEDEILCLEKELKEEKSKH-----SEQDELMADISKR-------------IQSLEDESK 152
            E++ +I   ++E+ + K  H     S Q  L A+I  R             +  +E +  
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636

Query: 153  SLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNK 212
                  AEA   ++  Q   +  +I + DAL     L+E    + + A + + ++ EL  
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696

Query: 213  QKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESEN 272
                 E S+  AEQ L D    ++ L  +   + +    L  DI+       ++  E+ N
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

Query: 273  GAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQ--- 329
                    + A K +  AA +   LK  +          + +++ K+ + + +K+LQ   
Sbjct: 1757 A------EEKAKKAITDAAMMAEELKKEQDTS-------AHLERMKKNMEQTVKDLQLRL 1803

Query: 330  --TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSK 387
               EQ +L+      + + QKL+ +++ +     E E++  +K   E    L K E+  K
Sbjct: 1804 DEAEQLALKGG----KKQIQKLEARVREL-----EGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 388  VDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLND 447
               ++++ TEE      R +DL ++L+  + SY+ Q    E++++ N    R  +  L  
Sbjct: 1855 ---ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL-- 1909

Query: 448  LRKENAHNRQKLTETEL 464
               E A  R  + E+++
Sbjct: 1910 ---EEAEERADIAESQV 1923



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 85/434 (19%), Positives = 168/434 (38%), Gaps = 74/434 (17%)

Query: 89   EKEATEAQ----SLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRI 144
            EKE +E +     L +  E ++++   LE     LE +L E KSK  EQ  L+ D++ + 
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283

Query: 145  QSLE----------DESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQK 194
              L+          DE ++L SQ++  K  F       E LK  +++ +   + L  + +
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFT---QQIEELKRQLEEEIKAKNALAHALQ 1340

Query: 195  QLLQEAEVWKEQVSELNKQKVTF-----------------------------EDSKVHAE 225
                + ++ +EQ  E  + K                                E++K    
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400

Query: 226  QVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALK 285
            Q L   E H++ +  +   ++     L  ++ D   L L++   +   A LD   +   K
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED---LMLDVERTNAACAALDKKQRNFDK 1457

Query: 286  KLIH----AAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENT- 340
             L        + +A L+  + E   +  +L ++    EE  + ++ L+ E  +LQ E + 
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517

Query: 341  -------------HFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSK 387
                           E   ++++Q+   +    +E E  L  +       +LE  +  S+
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577

Query: 388  VDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLND 447
            VD KI+   EE++        L+    R + S Q  + +  +  +D     +  E +LN+
Sbjct: 1578 VDRKIAEKDEEID-------QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630

Query: 448  LRKENAHNRQKLTE 461
            +  +  H  +   E
Sbjct: 1631 MEIQLNHANRMAAE 1644



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 79/415 (19%), Positives = 162/415 (39%), Gaps = 21/415 (5%)

Query: 54   SGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKE-ATEAQSLEATCEKLNRSNSEL 112
            S  IE   K   +F  ++++ E   ++     A+  K+ A     L    + L R   +L
Sbjct: 1164 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223

Query: 113  EDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNE 172
            E E   ++ E+ +  S      +   ++ K  ++LED+   LKS+  E +          
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283

Query: 173  ERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE 232
             RL+    +   +  + +    QL +  + + +Q+ EL +Q      +K      L    
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR 1343

Query: 233  SHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAK 292
                 L E+  + ++  A L   ++  +    +  ++ E  A          KK     K
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK-----K 1398

Query: 293  LNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQK 352
            L   L+  E     +  + + ++KTK+ L   +++L  +   ++  N      ++K +  
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD---VERTNAACAALDKKQRNF 1455

Query: 353  LKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEE 412
             K++ E  Q+ E + H +L   +        +L K+      + ++LET ++  K+L++E
Sbjct: 1456 DKILAEWKQKCE-ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514

Query: 413  LERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFE 467
                I     QI    K+ H+        E+    + +E    +  L E E   E
Sbjct: 1515 ----ISDLTEQIAEGGKRIHE-------LEKIKKQVEQEKCELQAALEEAEASLE 1558



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 28/139 (20%), Positives = 66/139 (47%), Gaps = 11/139 (7%)

Query: 79   VESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMA 138
            +E ++KD     +  E  +L+   +++ +    LE  +  LE E++ E+ +++E  + + 
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQK----LEARVRELEGEVESEQKRNAEAVKGLR 1847

Query: 139  DISKRIQSL-----EDESKSLKSQVAEAKMTFKI--FQMNEERLKIAIKDALNENSQLQE 191
               +R++ L     ED    L+ Q    K+  K+  ++   E  +      L +  +LQ 
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907

Query: 192  SQKQLLQEAEVWKEQVSEL 210
              ++  + A++ + QV++L
Sbjct: 1908 ELEEAEERADIAESQVNKL 1926


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 97/438 (22%), Positives = 192/438 (43%), Gaps = 46/438 (10%)

Query: 57   IEEKSKLLEKFSLVQKEYEG-YEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDE 115
            +E+K K  ++    +K     Y  E    +A   ++ T+A SL    E+     +ELE  
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498

Query: 116  ILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERL 175
                  E+++  S   +  + + ++ K  ++LE + + +K+Q+ E +   +  +  + RL
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558

Query: 176  KIAI--------KDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQV 227
            ++ +        +D    + Q +E +KQL+++    + ++ +  KQ+     ++   E  
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618

Query: 228  LNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKL 287
            L D E+HI +      K +D      E I     L+ +M         LD+      + L
Sbjct: 1619 LKDLEAHIDSAN----KNRD------EAIKQLRKLQAQMKDCMRE---LDDTRASREEIL 1665

Query: 288  IHAAKLNASLKTLEGERNQIYIQLSEVDKTK-------EELTEHIKNLQTEQASLQSENT 340
              A +    LK++E E  Q+  +L+  ++ K       +EL + I N   + A    E  
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725

Query: 341  HFENENQKLQQKLKVM---TELYQENEMKLHRKLT-VEENYRLEKEEKLSKVDEKISHAT 396
              E    +L+++L+     TEL  +   K + ++  +  +  LE+        +K  +A 
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA-----QKNENAR 1780

Query: 397  EELETYRKRAKDLEEELERTIHS-YQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHN 455
            ++LE   K  K   +E+E T+ S Y+  I + E K       A+  E+  N+ ++  A  
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAK------IAQLEEQLDNETKERQAAC 1834

Query: 456  RQ-KLTETELKFELLEKD 472
            +Q + TE +LK  LL+ D
Sbjct: 1835 KQVRRTEKKLKDVLLQVD 1852



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 98/440 (22%), Positives = 199/440 (45%), Gaps = 74/440 (16%)

Query: 31   WRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEK 90
            WR F  V+  L V R+++                    ++ KE E  +V    K  + E 
Sbjct: 828  WRLFTKVKPLLQVSRQEE-------------------EMMAKEEELVKVRE--KQLAAEN 866

Query: 91   EATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDE 150
              TE ++L+          S+L  E L L+++L+ E    +E +EL A ++ + Q LE+ 
Sbjct: 867  RLTEMETLQ----------SQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEI 916

Query: 151  SKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKE-QVSE 209
               L+++V E +   +  Q  +++++  I++ L E  + +ES +Q LQ  +V  E ++ +
Sbjct: 917  CHDLEARVEEEEERCQHLQAEKKKMQQNIQE-LEEQLEEEESARQKLQLEKVTTEAKLKK 975

Query: 210  LNKQKVTFEDSK---VHAEQVLNDKESHIKT-LTERLLKMKDWAAMLGEDITDDDNLELE 265
            L ++++  ED        +++L D+ +   T LTE   K K  A +  +      +LE  
Sbjct: 976  LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEER 1035

Query: 266  MNSESENGAYLDNPPK-------------GALKKLIHAAK---------LNASLKTLEGE 303
            +  E +    L+   +               L+  I   K         L A+L  +E E
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095

Query: 304  RNQIYIQLSEVDKTKEELTEHIKNLQTEQAS---LQSENTHFENENQKLQQKLK------ 354
              Q  + L ++ + + +++E  ++L++E+AS    + +      E + L+ +L+      
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155

Query: 355  -VMTELYQENEMKLH-RKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEE 412
                EL  + E +++  K T+EE  +   E ++ ++ +K S A EEL    ++ K ++  
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTH-EAQIQEMRQKHSQAVEELAEQLEQTKRVKAN 1214

Query: 413  LER---TIHSYQGQIISHEK 429
            LE+   T+ + +G++ +  K
Sbjct: 1215 LEKAKQTLENERGELANEVK 1234



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 75/415 (18%), Positives = 176/415 (42%), Gaps = 59/415 (14%)

Query: 59   EKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILC 118
            + + L ++ + +Q +    +++ + K+   +      +   A      +   ELE +I  
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115

Query: 119  LEKELKEEKSKHSEQDELMADISKRIQSLEDESK-SLKSQVAEAKMTFKIFQMNEERLKI 177
            L+++L+ E++  ++ ++   D+ + +++L+ E + +L S  A+ ++  K  Q      K 
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175

Query: 178  AIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKT 237
              ++A    +Q+QE +++  Q  E   EQ+ +  + K   E +K   E    +  + +K 
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235

Query: 238  LTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASL 297
            L                         L+   +SE+                         
Sbjct: 1236 L-------------------------LQGKGDSEH-----------------------KR 1247

Query: 298  KTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMT 357
            K +E +  ++ ++ +E ++ + EL + +  LQ E  ++    +  ++++ KL +    + 
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL- 1306

Query: 358  ELYQENEMKLHRKLTVEEN-YRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERT 416
                E++++  ++L  EEN  +L    KL +V+++ +   E+LE      ++ +  LE+ 
Sbjct: 1307 ----ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE----EEEEAKHNLEKQ 1358

Query: 417  IHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEK 471
            I +   Q+   +KK  D+      AE     L+K+     Q+  E    ++ LEK
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 90/458 (19%), Positives = 185/458 (40%), Gaps = 33/458 (7%)

Query: 43   VGREKKLALMLSGLIEEKSKLLEKF--SLVQKEYEGYEVESSLKDASFEKEATEAQSLEA 100
            +  E K+ L   G  E K K +E     L  K  EG  V + L D    K   E  ++  
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD-KVTKLQVELDNVTG 1287

Query: 101  TCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAE 160
               + +  +S+L  +   LE +L++ +    E++     +S +++ +EDE  S + Q+ E
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE 1347

Query: 161  AKMTFKIFQMNEERLKIAIKDA---LNENSQLQESQKQLLQEAEVWKEQVSELNKQKVT- 216
             +      +     L   + D    + ++    E+ +++ ++ +   E +S+ +++KV  
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407

Query: 217  ---FEDSKVHAEQVLNDK----ESHIKTLTERLLKMKDWAAMLGEDIT-------DDDNL 262
                E +K   +Q L+D     +   ++      K K +  +L E+ T       + D  
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRA 1467

Query: 263  ELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELT 322
            E E   +      L    + A+++     +LN   +T   E   +     +V K+  EL 
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELE 1524

Query: 323  EHIKNLQTEQASLQSENTHFENENQKLQQ-KLKVMTELYQENEMKLHRKLTVEENYRLEK 381
            +  + L+ +   ++++    E+E Q  +  KL++   L Q  + +  R L   +    EK
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL-QAMKAQFERDLQGRDEQSEEK 1583

Query: 382  EEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNA 441
            +++L +   ++    E+    R  A    ++LE  +   +  I S  K   +     R  
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643

Query: 442  E-------RNLNDLRKENAHNRQKLTETELKFELLEKD 472
            +       R L+D R        +  E E K + +E +
Sbjct: 1644 QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 77/372 (20%), Positives = 154/372 (41%), Gaps = 44/372 (11%)

Query: 58   EEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEIL 117
            E+K +L+ +   ++ E E    + S+  A+ +K   + + LEA  +  N++  E   ++ 
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641

Query: 118  CLEKELK----EEKSKHSEQDELMADIS---KRIQSLEDESKSLKSQVAEAKMTFKIFQM 170
             L+ ++K    E     + ++E++A      K+++S+E E   L+ ++A A+   +  Q 
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701

Query: 171  NEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLND 230
              + L   I ++  + +   E +++L  EA +                      E+ L +
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRL--EARI-------------------AQLEEELEE 1740

Query: 231  KESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENG-AYLDNPPKGALKKLIH 289
            ++ + + + +RL K    A +  + I  D NLE     ++EN    L+   K    KL  
Sbjct: 1741 EQGNTELINDRLKK----ANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQE 1796

Query: 290  -----AAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTE-QASLQSENTHFE 343
                  +K  AS+  LE +  Q+  QL    K ++   + ++  + + +  L   +    
Sbjct: 1797 MEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERR 1856

Query: 344  NENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYR 403
            N  Q   Q  K  T L Q     L R+L   E           K+  ++  ATE  +   
Sbjct: 1857 NAEQYKDQADKASTRLKQ-----LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911

Query: 404  KRAKDLEEELER 415
            +    L+ +L R
Sbjct: 1912 REVSSLKNKLRR 1923


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 100/466 (21%), Positives = 207/466 (44%), Gaps = 77/466 (16%)

Query: 38  RSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGY---------EVESSLKDASF 88
           ++R+ V +E   AL L   I E+S+ L++    ++EY+           ++E  L  A  
Sbjct: 523 QARMEVSQEDDKALQLLHDIREQSRKLQEIK--EQEYQAQVEEMRLMMNQLEEDLVSARR 580

Query: 89  EKEATEAQSLEA--TCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQS 146
             +  E++  E+    E+  R  +E + ++L  + + K E  ++++ +++ A+   +IQ 
Sbjct: 581 RSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQE 640

Query: 147 LEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQ 206
           L+++ +       EA    +  +  +ER +  ++   N     +  +K+L+ EAE  +E+
Sbjct: 641 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLV-EAEELEEK 699

Query: 207 VSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEM 266
             E    +V+ +  +VH +Q     E  IK L  ++ K          D+ D + LE  M
Sbjct: 700 HRE---AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKK----------DLADKETLE-NM 745

Query: 267 NSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVD----------- 315
               E  A+         K +I+A  +++ +++LE    Q  ++LSE +           
Sbjct: 746 MQRHEEEAHEKGKILSEQKAMINA--MDSKIRSLE----QRIVELSEANKLAANSSLFTQ 799

Query: 316 ---KTKEELTEHIKN----LQTEQASLQSENTHFENENQK--------------LQQKLK 354
              K +EE+   ++     L+T+   L+++N   E + +K              L+ +L+
Sbjct: 800 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLR 859

Query: 355 VMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELE 414
            ++  ++E +++L R+LT  +    E+E +L+     +  A   LE+  ++AK   EE  
Sbjct: 860 EVSLEHEEQKLELKRQLTELQLSLQERESQLT----ALQAARAALESQLRQAKTELEETT 915

Query: 415 RTIHSYQGQIISHEKKAHDNWLAARNA-------ERNLNDLRKENA 453
                    + +H  +    + A RN+       E  LN L ++NA
Sbjct: 916 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNA 961



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 80/385 (20%), Positives = 167/385 (43%), Gaps = 18/385 (4%)

Query: 50   ALMLSGLIEEKSKLLEKFSLVQKEYEG---YEVESSLKDASFEKEATEAQSLEATCEKLN 106
            A + S L + K++L E  +  ++E +    +  E   K  +     T    LE    +L 
Sbjct: 898  AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLT 957

Query: 107  RSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFK 166
              N+EL ++   L K+L E    + E  +L +++    + + +    L SQ    +    
Sbjct: 958  EDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKT 1017

Query: 167  IFQMNEERLK--IAIKDALNENSQLQESQKQLL-QEAEVWKEQVSELNKQKVTFEDSKVH 223
               M EE++    A+ D L E  +  E+ + +L  E   ++ +V EL +   T + S+  
Sbjct: 1018 TCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRAR 1077

Query: 224  AEQVLNDKESHIK-TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKG 282
            A+Q + +    ++  + E   ++      L E     ++L  ++N   +  A L+   + 
Sbjct: 1078 ADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARS 1137

Query: 283  ALKKLIHAAKLNASLKTLEGE-RNQIYIQLSEVDKTKEELTEHIKN---LQTEQASL--Q 336
              +KL    +L   L   + + + Q+ +Q + + +  + L E +     L+TE++ L  Q
Sbjct: 1138 LQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 1197

Query: 337  SENTH--FENENQKLQQKLKVMTELYQENEMKLHRKLTVEE---NYRLEKEEKLSKVDEK 391
             EN    + +E  K++  +   T+L    + K+ +    ++   + R E     ++V  +
Sbjct: 1198 LENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQ 1257

Query: 392  ISHATEELETYRKRAKDLEEELERT 416
             +     LE  + R  +LEE L++T
Sbjct: 1258 YNELKLALEKEKARCAELEEALQKT 1282



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 95/438 (21%), Positives = 182/438 (41%), Gaps = 77/438 (17%)

Query: 57   IEEKSKLLEKFSL-VQKEYEGYE-VESSLKDASFEKEAT----EAQS--LEATCEKLNRS 108
            + E +KL    SL  Q+  +  E + S L+   F  E      EAQ+  LE   EK++  
Sbjct: 784  LSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ 843

Query: 109  NSELEDEILCLEKELKEEKSKHSEQD--------ELMADISKR---IQSLEDESKSLKSQ 157
            +   ++ +L LE  L+E   +H EQ         EL   + +R   + +L+    +L+SQ
Sbjct: 844  DHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQ 903

Query: 158  VAEAKMTFK---------IFQMNEERLKIAIK-DALNEN----SQLQESQKQLLQE-AEV 202
            + +AK   +         I  +   R +I  K DAL  +    + L+E   QL ++ AE+
Sbjct: 904  LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 963

Query: 203  ---------WKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLG 253
                       ++ S  N + V       H  + + ++E  + +  + +  +K    ML 
Sbjct: 964  NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE 1023

Query: 254  EDITD-----DDNLELEMNSESENGAYLDNPPK-----GALKKLIHAAK---------LN 294
            E + D     D+ LE E   E+      D   +       L++++   K         + 
Sbjct: 1024 EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRIT 1083

Query: 295  ASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLK 354
             S + +E    +   ++  + +  +E     ++L  +   L+ ++   E   + LQQKL+
Sbjct: 1084 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 1143

Query: 355  VMTELYQ---ENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEE 411
               EL Q   E + KL +++ +++N+       + ++ + +  A +  +  +    DLE 
Sbjct: 1144 TERELKQRLLEEQAKLQQQMDLQKNH-------IFRLTQGLQEALDRADLLKTERSDLEY 1196

Query: 412  ELERTIHSYQGQIISHEK 429
            +LE     Y     SHEK
Sbjct: 1197 QLENIQVLY-----SHEK 1209



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 102/474 (21%), Positives = 189/474 (39%), Gaps = 104/474 (21%)

Query: 79  VESSLKDASFEKE----ATEAQSLEATCEK-------LNRSNSELEDEILCLEKELKEEK 127
           ++S  K +S EK+    + E Q  +  C K       L+R  SE+E  +   E ELK  +
Sbjct: 438 LDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASE 497

Query: 128 SKHS--EQD--------------------ELMADISKRIQSLED---------ESKSLKS 156
           ++ S  EQD                    E+  +  K +Q L D         E K  + 
Sbjct: 498 TQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY 557

Query: 157 QVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQES--------------QKQLLQEAEV 202
           Q    +M   + Q+ E+ +    +  L E S+L+ES              Q +LL+  + 
Sbjct: 558 QAQVEEMRLMMNQLEEDLVSARRRSDLYE-SELRESRLAAEEFKRKATECQHKLLKAKDQ 616

Query: 203 WKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNL 262
            K +V E  K +      K++AEQ L      I+ L E+L K    +    E + +    
Sbjct: 617 GKPEVGEYAKLE------KINAEQQLK-----IQELQEKLEKAVKASTEATELLQNIRQA 665

Query: 263 ELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEE-- 320
           +     E E     ++  +G  KKL+ A +L    +  +     + + L + ++  EE  
Sbjct: 666 KERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKI 725

Query: 321 --LTEHIKNLQTEQASLQSENTHFENE------------------NQKLQQKLKVMTELY 360
             L   IK    ++ +L++     E E                  + K++   + + EL 
Sbjct: 726 KVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS 785

Query: 361 QENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSY 420
           + N++  +  L  + N + + EE +S++ ++  +   +      + + LEE+LE+     
Sbjct: 786 EANKLAANSSLFTQRNMKAQ-EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK----- 839

Query: 421 QGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTE--TELKFELLEKD 472
               ISH+  +  N L     E  L ++  E+   + +L    TEL+  L E++
Sbjct: 840 ----ISHQDHSDKNRLL--ELETRLREVSLEHEEQKLELKRQLTELQLSLQERE 887


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 89/445 (20%), Positives = 193/445 (43%), Gaps = 46/445 (10%)

Query: 58  EEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEIL 117
           EE+ +  ++ ++++KE E  + E   +    ++E  + + LE    +  R   E + + L
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300

Query: 118 CLEKEL--KEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERL 175
             E++L  K+E+ +  +Q+E      +R Q  E   + L+ +  E +      +  EER 
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360

Query: 176 KIAIKDALNENSQLQE--SQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKES 233
           +  ++    E  + Q+   ++QL +E ++ +EQ  +L +++    + ++  EQ L  ++ 
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQ--QLRREQQLRREQQLRREQQLRREQQ 418

Query: 234 HIKTLTERLLKMKDWAAMLGEDITDDDNLELE-------MNSESENGAYLDNPPKGALKK 286
             +    R  + ++      E    +  L+ E       +  E E   +     K  LK+
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 287 LIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENEN 346
                         E ER + +++L E ++ +E+     + L+ EQ   + +    + E 
Sbjct: 479 ------------DQEEERRERWLKLEEEER-REQQERREQQLRREQEERREQRLKRQEEE 525

Query: 347 QKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEEL-----ET 401
           ++LQQ+L+   +L +E E +  + L  EE  RLE+E +  ++  +     ++L     E 
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585

Query: 402 YRKRAK-DLEEELERTIHSYQGQIISHEKKAHDN--------------WLAARNAERNLN 446
            ++R K + EE LE+ +   + + +  E++                    +    ER   
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645

Query: 447 DLRKENAHNRQKLTETELKFELLEK 471
            LR+E    R++  + E + E LE+
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQ 670



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 74/402 (18%), Positives = 169/402 (42%), Gaps = 39/402 (9%)

Query: 89  EKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKH-SEQDELMADISKRIQSL 147
           E+E  E +      E+L + + +  DE L  +++  +E+ +  +E+++L +      +  
Sbjct: 145 ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF 204

Query: 148 EDESKSLKSQVAEAK-------------MTFKIFQMNEERLKIAIKDAL-NENSQLQESQ 193
            DE +  + ++ E +                ++FQ  EE+     +  L  E  +LQE +
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 194 KQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLG 253
            Q  +E +  +EQ+ +L +Q++  E  +   +Q    +E  ++   E             
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE------------ 312

Query: 254 EDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSE 313
               +    + E   + E     +   +  L++     +     +  E ER +  ++  +
Sbjct: 313 ----ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368

Query: 314 VDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTV 373
            ++ +E+     + L+ EQ  L+ E      +  + +Q+L+   +L +E +++  ++L  
Sbjct: 369 EEERREQQLRREQQLRREQ-QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427

Query: 374 E-ENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQII--SHEKK 430
           E E  R E++ +  + ++++    EE   + KR    EEE ER     + Q +    E++
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKR----EEETERHEQERRKQQLKRDQEEE 483

Query: 431 AHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKD 472
             + WL     ER     R+E    R++    E + +  E++
Sbjct: 484 RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 77/401 (19%), Positives = 170/401 (42%), Gaps = 47/401 (11%)

Query: 65   EKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELK 124
            E+  L+++E E   ++   +    E+E  + +      E+  R   E       LE++ +
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE-------LERQYR 1081

Query: 125  EEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALN 184
            +E+    E+++L+ +  ++ +  E E +  + +  + +    + +  E+R +  ++    
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 185  ENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLK 244
            E  ++Q+ ++QLL+E E  K +  EL +Q    E+ +   EQ+L +++   +   ER  +
Sbjct: 1142 EEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200

Query: 245  MKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNA---SLKTLE 301
             ++                 E+  +     Y D   +  LK      K NA   +    +
Sbjct: 1201 EEE-----------------ELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243

Query: 302  GERNQIYIQLSEV---DKTKEELTEHI------KNLQTEQASLQSENTHFENENQ--KLQ 350
            G  N+ + QL +    D+  ++  +H+      ++ + E+   Q  + HF  E Q  + +
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303

Query: 351  QKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLE 410
            QK     +   + E +L R+   E+  R E + K  + ++ +    E  +  R++ +D +
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE--QPLRRQERDRK 1361

Query: 411  EELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKE 451
               E   H  QG+    E++        R  ER    L++E
Sbjct: 1362 FREEELRHQEQGRKFLEEEQ------RLRRQERERKFLKEE 1396



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 85/407 (20%), Positives = 164/407 (40%), Gaps = 48/407 (11%)

Query: 84   KDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKR 143
            K A  E+   E Q L+   E+L R   E        E++ +EE+    E+++L+ +  ++
Sbjct: 892  KPALQEQLRKEQQLLQEEEEELQREEREKRRRQE-QERQYREEEQLQQEEEQLLREEREK 950

Query: 144  IQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVW 203
             +  E E +  K +  + K    + +  E+R +   +    E  +LQ+ ++QLL+E E  
Sbjct: 951  RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE-ERE 1009

Query: 204  KEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLE 263
            K +  E  +Q    ++ +   EQ+L + E   + L ER  + +             +  E
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLRE-EREKRRLQERERQYR-------------EEEE 1055

Query: 264  LEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTE 323
            L+   E   G   +   +  L++              E E  Q   QL   +  K    E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRK----------EEELQQEEEQLLREEPEKRRRQE 1105

Query: 324  HIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEE 383
              +  + E+   Q E      E +K +++             +L R+   EE  + E+E+
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQ-------------ELERQYREEEEVQQEEEQ 1152

Query: 384  KLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAER 443
             L +  EK     +ELE   +  ++L++E E+ +   Q      EK+  +     R  E 
Sbjct: 1153 LLREEPEK--RRRQELERQYREEEELQQEEEQLLREEQ------EKRRQERERQYREEEE 1204

Query: 444  NLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPY 490
                 RK+   +  + ++ + ++E  EK+    D      GRE+  +
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWE-PEKENAVRDNKVYCKGRENEQF 1250



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 89/422 (21%), Positives = 175/422 (41%), Gaps = 50/422 (11%)

Query: 71   QKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELK-EEKSK 129
            ++E +  E E  L+     K   E Q L+   E+      E + + L  E++L+ +E+ +
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQER-EEQQLHRQERDRKFLEEEQQLRRQERDR 1501

Query: 130  HSEQDELMADISKRIQSLEDESKSLKSQ----VAEAKMTFKIFQMNEERLKIAIKDALNE 185
               + EL +   +R + LE+E +  + Q      + +   +  +  ++R +   +    E
Sbjct: 1502 KFREQELRSQEPER-KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560

Query: 186  NSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK---VHAEQVLNDKESHIKTLTERL 242
                QE ++Q L   E  +++   L +QKV  ++ +   +  EQ L  +E   +   ER 
Sbjct: 1561 EQLRQEREEQQLSRQE--RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618

Query: 243  LKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLK---- 298
             K ++   +L E        E +++ +  +  +L+  P+   ++     + +   K    
Sbjct: 1619 RKFREDEQLLQE------REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672

Query: 299  ---TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKV 355
                 EGE  Q+  Q  E D+   E  + ++  + E+  LQ E    +   Q+L++K + 
Sbjct: 1673 EQLLQEGEEQQLRRQ--ERDRKFREEEQQLRRQERERKFLQEEQ---QLRRQELERKFRE 1727

Query: 356  MTELYQENEMKL------HRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDL 409
              +L QE E +       +RK+  EE  R E+EE+  +  E+     EE        + L
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE--------EQL 1779

Query: 410  EEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELL 469
             +E E      + Q+ S E             ER    LR +    + +  E +L+ E  
Sbjct: 1780 RQERE------EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833

Query: 470  EK 471
            E+
Sbjct: 1834 EQ 1835



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 79/442 (17%), Positives = 180/442 (40%), Gaps = 57/442 (12%)

Query: 58  EEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEIL 117
           EE+ +L ++   ++ E +    +   ++   ++E  +    E   ++L R   E  D++L
Sbjct: 523 EEEERLQQR---LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579

Query: 118 CLEKELKEEKSKHSEQDELMADISKR-IQSLEDESKSLKSQVAEAKMTFKIFQMNEERLK 176
             E+E ++++ K  +++ L   + +  ++ LE E +         +   K  +  EER +
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERR--------EQRLKREEPEEERRQ 631

Query: 177 IAIKDALNENSQLQE--SQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESH 234
             +K    E  + Q+   ++Q  +E  + +E+  E  +Q++  E  +   EQ L ++E  
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ- 690

Query: 235 IKTLTERLL-KMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPK--GALKKLIHAA 291
            +   ER+  ++  W              +LE  +++        P K  G  ++     
Sbjct: 691 -EQARERIKSRIPKW------------QWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737

Query: 292 KLNASLKTLEG-ERNQIYIQLSEVDKTK--------EELTEHIKNLQTEQASLQSENTHF 342
           K       L+  E  + + Q  E ++ +        EE +E  +   + +  L+ +    
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797

Query: 343 ENENQKLQQKLKVMTELYQENEMKLHRKLT------VEENYRLEKEEKLSKVDEKISHAT 396
               ++ Q++ + + E  ++ + +  R+        +EE  +L++ E+  ++ E+     
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857

Query: 397 EELETYRKRAK--------DLEEELERTIHSYQGQIISHEKKAHDNWLAARNAE---RNL 445
           E+ E  R + +         LEEE +R  H+   +    E+   +  L     E   R  
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917

Query: 446 NDLRKENAHNRQKLTETELKFE 467
            + R+     RQ   E +L+ E
Sbjct: 918 REKRRRQEQERQYREEEQLQQE 939



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 69/373 (18%), Positives = 145/373 (38%), Gaps = 25/373 (6%)

Query: 103 EKLNRSNSELEDEILCLEKELKEEKSKHSEQ---DELMADISKRIQSLEDESKSLKSQVA 159
           ++L R      ++ L  E+E +  + KH ++     L  +  +R   L+ E ++ + +  
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470

Query: 160 EAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFED 219
             K   K  Q  E R +    +      Q +  ++QL +E E  +EQ  +  +++   + 
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530

Query: 220 SKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNP 279
                +Q+  ++E       E+LLK ++   +  E    +  L+ E     +     +  
Sbjct: 531 RLRSEQQLRREQEER----REQLLKREEEKRL--EQERREQRLKREQEERRDQLLKREEE 584

Query: 280 PKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN 339
            +    K     +L   LK  E ER      L + ++ ++ L       +  Q  L+SE 
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVER------LEQEERREQRLKREEPEEERRQQLLKSE- 637

Query: 340 THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEEL 399
              E E ++ QQ  +   E  ++   +   +  +E+  + E EE+  + +       +  
Sbjct: 638 ---EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694

Query: 400 ETYRKRAKDLEEELERTIHSYQGQIISH------EKKAHDNWLAARNAERNLNDLRKENA 453
           E  + R    + +LE    + Q ++ S       +++  +     R  E  L    +E A
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754

Query: 454 HNRQKLTETELKF 466
           H +Q+  E    F
Sbjct: 755 HRQQQEEEQRRDF 767



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 95/461 (20%), Positives = 181/461 (39%), Gaps = 63/461 (13%)

Query: 58   EEKSKLLEKFSLVQKEYEG---YEVESSLKDASFEKEATEAQSLEATCEKLNRSNSEL-- 112
            EE+    E+  L+++E E     E+E   ++   E +  E Q L    EK  R   E   
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEE-EVQQEEEQLLREEPEKRRRQELERQY 1170

Query: 113  -EDEILCLEKE--LKEEKSK--------HSEQDELMADISKRIQSLEDESKSLKSQVAEA 161
             E+E L  E+E  L+EE+ K        + E++EL     K+    ED+   LK Q    
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230

Query: 162  KMTF----KIFQMNEERLKIA-IKDALNENSQLQESQKQLL---------QEAEVWK--- 204
            K       K++    E  +   ++D+   + Q Q+  + LL         QE   W+   
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD 1290

Query: 205  ------EQVSELNKQKVTFEDSKVHAE-QVLNDKESHIKTLTERLLKMKDWAAMLGE--- 254
                  EQ+    +++    D K   E Q+L ++    +   E   K ++   +L E   
Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350

Query: 255  -----DITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYI 309
                    D    E E+  + +   +L+   +  L++     K     + L  +  +  +
Sbjct: 1351 QPLRRQERDRKFREEELRHQEQGRKFLEEEQR--LRRQERERKFLKEEQQLRCQEREQQL 1408

Query: 310  QLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKL-- 367
            +     K +EE          +Q S Q  +  F  E Q+++++ +    L +E +++   
Sbjct: 1409 RQDRDRKFREE---------EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459

Query: 368  HRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLE-EELERTIHSYQGQIIS 426
            HRK   EE    E+EE+     E+     EE +  R++ +D +  E E      + + + 
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519

Query: 427  HEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFE 467
             E++ H      +  +      R+E    R++  + + + E
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 72/390 (18%), Positives = 156/390 (40%), Gaps = 12/390 (3%)

Query: 38  RSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQS 97
           + RL   +E++L   L     E+ +  E+     K  E  E        S E+E    Q 
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 98  LEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMAD----ISKRIQSLEDESKS 153
           L    ++      + E+E   LE+ LK E  +   + EL  +      +RI+S   + + 
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706

Query: 154 LKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQ 213
                A+A+ + K++    ++     +    E  + +ES+ Q  +E    ++Q  E  ++
Sbjct: 707 QLESEADARQS-KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765

Query: 214 KVTF----EDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSE 269
             T+    E+      Q L+ +   ++   ER L+ ++        + +++  E      
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPP-LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824

Query: 270 SENGAYLDN-PPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVD-KTKEELTEHIKN 327
            E    L     +  L++   A +L      L+ ++ +   Q    D K + +L E  K 
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884

Query: 328 LQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSK 387
            +    +  +       E Q LQ++ + +    +E   +  ++    E  +L++EE+   
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944

Query: 388 VDEKISHATEELETYRKRAKDLEEELERTI 417
            +E+     +E E   ++ K L+++ E+ +
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLL 974



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 70/338 (20%), Positives = 142/338 (42%), Gaps = 47/338 (13%)

Query: 58   EEKSKLLEKFSLVQKEYEGYEVESSLKDASF-EKEATEAQSLEATCEKLNRSNSELEDEI 116
            E++ K +E    ++++ EG +     +D  F E E    +  E    +  R    LE+E 
Sbjct: 1592 EQERKFMEDEQQLRRQ-EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP 1650

Query: 117  LCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLK 176
              L ++ +E++ +H ++D    +  + +Q  E E + L+ Q  + K     F+  E++L+
Sbjct: 1651 Q-LRRQEREQQLRH-DRDRKFREEEQLLQ--EGEEQQLRRQERDRK-----FREEEQQLR 1701

Query: 177  IAIKDA--LNENSQL--QESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE 232
               ++   L E  QL  QE +++  +E ++ +E   E  +++  +    +  EQ+  ++E
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI-LEEEQLRPERE 1760

Query: 233  SHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAK 292
                   ER  K ++      E+    +  E ++ S+  +  + +               
Sbjct: 1761 EQQLRRQERDRKFRE------EEQLRQEREEQQLRSQESDRKFREE-------------- 1800

Query: 293  LNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQK 352
                 + L  ER +  ++  + D       E ++  + EQ   Q  +  +  E Q   Q+
Sbjct: 1801 -----EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855

Query: 353  L--KVMTELYQENEMKLH----RKLTVEENYRLEKEEK 384
               +   EL+QE E K      RKL  E   R +KEE+
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 97/488 (19%), Positives = 206/488 (42%), Gaps = 88/488 (18%)

Query: 66   KFSLVQKEYEGYEVESSLK--DASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKEL 123
            K  L  ++   +E+E   +  D+   +   EAQ  +   EKL R    L  E   L+++L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502

Query: 124  KEE---------------------KSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAK 162
            +E+                      S+ S+ +  +A + K+++ LE + K  + ++ E  
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562

Query: 163  MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKV 222
             T ++ +  + RL++ ++     +S+  ES+ + ++EA   +    +L + +V  E+   
Sbjct: 1563 GTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR--QSCQKKLKQMEVQLEEEYE 1620

Query: 223  HAEQVLNDK---ESHIKTLTERLLK------------MKDWAAMLGEDITDDDNLELEMN 267
              ++VL +K   E  + TL++++ +            +K   A+L +     D+L+    
Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680

Query: 268  SESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKN 327
            S+ E  A L N  + +      A K   + K +E E   +++Q+ ++ K K  L E +  
Sbjct: 1681 SKREI-AQLKNQLEESEFTCAAAVK---ARKAMEVEIEDLHLQIDDIAKAKTALEEQLSR 1736

Query: 328  LQTE---------------------------QAS--------LQSENTHFENENQKLQQK 352
            LQ E                           QAS        LQ++      E Q+LQ+K
Sbjct: 1737 LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEK 1796

Query: 353  LKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEE 412
            L+ +     +++++   +  V+++    +E K+ +++ ++     +++     A  L+E 
Sbjct: 1797 LQAL-----QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKEN 1851

Query: 413  LERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKD 472
            +E+       +I +  ++   N    +  +R L D ++E     +K  E   K   LE D
Sbjct: 1852 MEKLTEERDQRIAAENREKEQN----KRLQRQLRDTKEEMGELARKEAEASRKKHELEMD 1907

Query: 473  PYALDVPN 480
              +L+  N
Sbjct: 1908 LESLEAAN 1915



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 94/467 (20%), Positives = 193/467 (41%), Gaps = 54/467 (11%)

Query: 31   WRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEK 90
            W+ F +VR  + V   ++    +    EE  +L  K    +KE     + S   ++   +
Sbjct: 1237 WKLFTTVRPLIEVQLSEE---QIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISE 1293

Query: 91   EATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDE 150
              +E      T E  ++       E L  EKE+KE ++++               +L+ +
Sbjct: 1294 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQY--------------DALKKQ 1339

Query: 151  SKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSEL 210
             + ++ +V EA++  +  ++N E       D  +   + +   ++ ++E +  K+++ + 
Sbjct: 1340 MEVMEMEVMEARL-IRAAEINGE------VDDDDAGGEWRLKYERAVREVDFTKKRLQQE 1392

Query: 211  NKQKVTFE-DSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELE---- 265
             + K+  E  +K   E+ L D ++  +     L ++K     L  ++  D  L LE    
Sbjct: 1393 FEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL-QDTKLHLEGQQV 1451

Query: 266  MNSESEN-----GAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEE 320
             N E E       + L    + A ++ +   KL      L  E   +  QL E D     
Sbjct: 1452 RNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAG 1511

Query: 321  LTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHR-----KLTVEE 375
             T+ + +L+ E   + S+ +  E    K++++L+ +    ++ E +L       ++  + 
Sbjct: 1512 FTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQA 1571

Query: 376  NYRLEKE-EKLSKVDEK-ISHATEELETYR----KRAKDLEEELERTIHSYQGQIISHEK 429
              RLE E E++ +   K +    EE+E  R    K+ K +E +LE      Q   +  EK
Sbjct: 1572 KLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQK--VLREK 1629

Query: 430  KAHDNWLAARNAERNLND------LRKENAHNRQKLTETELKFELLE 470
            +  +  LA  + + N  D      LRK+    +  L + +L  + L+
Sbjct: 1630 RELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLK 1676



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 78/387 (20%), Positives = 158/387 (40%), Gaps = 45/387 (11%)

Query: 47   KKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLN 106
            K++ + L    E+K K+L          E  E+E  L   S +    + +S +   + L 
Sbjct: 1609 KQMEVQLEEEYEDKQKVLR---------EKRELEGKLATLSDQVNRRDFESEKRLRKDLK 1659

Query: 107  RSNSELEDEILCLE---------KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQ 157
            R+ + L D  L L+         +E+ + K++  E +   A   K  +++E E + L  Q
Sbjct: 1660 RTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQ 1719

Query: 158  V---AEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQK 214
            +   A+AK         EE+L    ++     ++L+E Q+ + +  +  K  V++ ++  
Sbjct: 1720 IDDIAKAKTAL------EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL 1773

Query: 215  VTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNL--------ELEM 266
                D +   E+   +K+     L E+L  ++     L + + D   +        ELE 
Sbjct: 1774 AQINDLQAQLEEANKEKQE----LQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELET 1829

Query: 267  NSESENGAY-----LDNPPKGALKKLIHAAKLNASLKTLEGERNQ-IYIQLSEVDKTKEE 320
              E E         L +  K  ++KL        + +  E E+N+ +  QL +  +   E
Sbjct: 1830 RLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGE 1889

Query: 321  LTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLE 380
            L         ++  L+ +    E  NQ LQ  LK+  +   + +  +  ++  +EN  L 
Sbjct: 1890 LARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLI 1949

Query: 381  KEEKLSKVDEKISHATEELETYRKRAK 407
              E  S VD ++    + ++++  + K
Sbjct: 1950 NSEGDSDVDSELEDRVDGVKSWLSKNK 1976


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 97/488 (19%), Positives = 206/488 (42%), Gaps = 88/488 (18%)

Query: 66   KFSLVQKEYEGYEVESSLK--DASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKEL 123
            K  L  ++   +E+E   +  D+   +   EAQ  +   EKL R    L  E   L+++L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502

Query: 124  KEE---------------------KSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAK 162
            +E+                      S+ S+ +  +A + K+++ LE + K  + ++ E  
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562

Query: 163  MTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKV 222
             T ++ +  + RL++ ++     +S+  ES+ + ++EA   +    +L + +V  E+   
Sbjct: 1563 GTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR--QSCQKKLKQMEVQLEEEYE 1620

Query: 223  HAEQVLNDK---ESHIKTLTERLLK------------MKDWAAMLGEDITDDDNLELEMN 267
              ++VL +K   E  + TL++++ +            +K   A+L +     D+L+    
Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680

Query: 268  SESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKN 327
            S+ E  A L N  + +      A K   + K +E E   +++Q+ ++ K K  L E +  
Sbjct: 1681 SKREI-AQLKNQLEESEFTCAAAVK---ARKAMEVEIEDLHLQIDDIAKAKTALEEQLSR 1736

Query: 328  LQTE---------------------------QAS--------LQSENTHFENENQKLQQK 352
            LQ E                           QAS        LQ++      E Q+LQ+K
Sbjct: 1737 LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEK 1796

Query: 353  LKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEE 412
            L+ +     +++++   +  V+++    +E K+ +++ ++     +++     A  L+E 
Sbjct: 1797 LQAL-----QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKEN 1851

Query: 413  LERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKD 472
            +E+       +I +  ++   N    +  +R L D ++E     +K  E   K   LE D
Sbjct: 1852 MEKLTEERDQRIAAENREKEQN----KRLQRQLRDTKEEMGELARKEAEASRKKHELEMD 1907

Query: 473  PYALDVPN 480
              +L+  N
Sbjct: 1908 LESLEAAN 1915



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 94/467 (20%), Positives = 193/467 (41%), Gaps = 54/467 (11%)

Query: 31   WRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEK 90
            W+ F +VR  + V   ++    +    EE  +L  K    +KE     + S   ++   +
Sbjct: 1237 WKLFTTVRPLIEVQLSEE---QIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISE 1293

Query: 91   EATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDE 150
              +E      T E  ++       E L  EKE+KE ++++               +L+ +
Sbjct: 1294 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQY--------------DALKKQ 1339

Query: 151  SKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSEL 210
             + ++ +V EA++  +  ++N E       D  +   + +   ++ ++E +  K+++ + 
Sbjct: 1340 MEVMEMEVMEARL-IRAAEINGE------VDDDDAGGEWRLKYERAVREVDFTKKRLQQE 1392

Query: 211  NKQKVTFE-DSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELE---- 265
             + K+  E  +K   E+ L D ++  +     L ++K     L  ++  D  L LE    
Sbjct: 1393 FEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL-QDTKLHLEGQQV 1451

Query: 266  MNSESEN-----GAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEE 320
             N E E       + L    + A ++ +   KL      L  E   +  QL E D     
Sbjct: 1452 RNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAG 1511

Query: 321  LTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHR-----KLTVEE 375
             T+ + +L+ E   + S+ +  E    K++++L+ +    ++ E +L       ++  + 
Sbjct: 1512 FTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQA 1571

Query: 376  NYRLEKE-EKLSKVDEK-ISHATEELETYR----KRAKDLEEELERTIHSYQGQIISHEK 429
              RLE E E++ +   K +    EE+E  R    K+ K +E +LE      Q   +  EK
Sbjct: 1572 KLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQK--VLREK 1629

Query: 430  KAHDNWLAARNAERNLND------LRKENAHNRQKLTETELKFELLE 470
            +  +  LA  + + N  D      LRK+    +  L + +L  + L+
Sbjct: 1630 RELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLK 1676



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 78/390 (20%), Positives = 156/390 (40%), Gaps = 57/390 (14%)

Query: 47   KKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLN 106
            K++ + L    E+K K+L          E  E+E  L   S +    + +S +   + L 
Sbjct: 1609 KQMEVQLEEEYEDKQKVLR---------EKRELEGKLATLSDQVNRRDFESEKRLRKDLK 1659

Query: 107  RSNSELEDEILCLE---------KELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQ 157
            R+ + L D  L L+         +E+ + K++  E +   A   K  +++E E + L  Q
Sbjct: 1660 RTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQ 1719

Query: 158  V---AEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQK 214
            +   A+AK         EE+L    ++     ++L+E Q+ + +  +  K  V++ ++  
Sbjct: 1720 IDDIAKAKTAL------EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL 1773

Query: 215  VTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNL--------ELEM 266
                D +   E+   +K+     L E+L  ++     L + + D   +        ELE 
Sbjct: 1774 AQINDLQAQLEEANKEKQE----LQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELET 1829

Query: 267  NSESENGAY-----LDNPPKGALKKLIHAAKLNASLKTLEGERNQ-IYIQLSEVDKTKEE 320
              E E         L +  K  ++KL        + +  E E+N+ +  QL +  +   E
Sbjct: 1830 RLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGE 1889

Query: 321  LTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLE 380
            L         ++  L+ +    E  NQ LQ  LK+  +   + +  +  ++  +EN    
Sbjct: 1890 LARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDEN---- 1945

Query: 381  KEEKLSKVDEKISHATEELETYRKRAKDLE 410
                    ++ I+   + +  Y+KR   LE
Sbjct: 1946 --------EDLINSLQDMVTKYQKRKNKLE 1967


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 104/506 (20%), Positives = 213/506 (42%), Gaps = 104/506 (20%)

Query: 46  EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEV-ESSLKDASFEKEATEAQSLEATCEK 104
           +  L  +L  + ++  K+    +L+QK  E   + E   +D   + +A E ++  A   +
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET--AVLNQ 565

Query: 105 LNRSNSELEDEILCLEKELKEEKSKHSEQDELMAD-----------ISKRIQSLEDESKS 153
           L   N  L++++  L ++LK +   H +  E + D              R+ SLE     
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625

Query: 154 LKSQVAEAKMTFKIFQMN---EERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSEL 210
           L SQ+ E+K   K+ Q++   + + ++ +     + +Q  + Q  L       +++  EL
Sbjct: 626 LNSQLNESKE--KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683

Query: 211 NK-----QKVT--FEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDIT--DDDN 261
           NK      +VT   +D + H  Q+    ESH+K   E+ L ++     L   I   + D+
Sbjct: 684 NKITTQLDQVTAKLQDKQEHCSQL----ESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739

Query: 262 LELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERN-QIYIQLSEVDKTKEE 320
           LE++ + E             AL+ L    +LN  L+    E + Q+ ++   V  T+ +
Sbjct: 740 LEVKASKEQ------------ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD 787

Query: 321 LTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTE----LYQENEMKLHRKLTVEEN 376
           L +  + L+    S++ + T  E E Q L+Q  + +++     ++E   ++   +T  + 
Sbjct: 788 LQKKSEALE----SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843

Query: 377 YRLEKE----------EKLSKVDEKISHATEELETYRKRAKDLEEELERT---------- 416
            ++EKE          +KLSKV + + ++  E E   ++ K    +LE+T          
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903

Query: 417 -----------------------------IHSYQGQIISHEKKAHDNWLAARNAERNLND 447
                                        ++S Q Q+I  +     N    +  + N+N+
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963

Query: 448 LRKENAHNRQKL--TETELKFELLEK 471
           L++ +   ++++   + ELK  +L+K
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQK 989



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 89/449 (19%), Positives = 193/449 (42%), Gaps = 44/449 (9%)

Query: 58  EEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSE--LEDE 115
           EE  K LEK+  +Q++    + +  + D+S E ++ E Q  EA  E  N    +   E +
Sbjct: 107 EELKKELEKYQGLQQQEA--KPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQK 164

Query: 116 ILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERL 175
              L  E+ + KSK+ E+  L     +++  L +E     + + + K T  + +   E +
Sbjct: 165 AAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK-TELLQRPGIEDV 223

Query: 176 KIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHI 235
            +  K+ +   + +     +  +E+E  K++  +L  Q  + E +       L      +
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 283

Query: 236 KTLTERLLKMKDWAAML---GEDITDD------DNLELEMNSESENGAYLDNPPKGALKK 286
               + L K+K     L    + +T++      D  +LE    +E      N      +K
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE-EKHNEESVSKKNIQATLHQK 342

Query: 287 LIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENEN 346
            +   +L + L   E   ++I+++LSE  +  ++L E +  ++T+   L++E    + + 
Sbjct: 343 DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 402

Query: 347 QKLQQK-LKVMTELYQ---------------ENEMKLHRKLTVEENYRLEKEEKLSKVDE 390
           ++ +Q  L++ +E+ Q                  +K  R+L+ E+   ++KE++++ +  
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK--LMDKEQQVADLQL 460

Query: 391 KISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRK 450
           K+S   E+L+     + +L+ +L++T   +Q Q    +          R A+ +L  + +
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ----QALQQSTTAKLREAQNDLEQVLR 516

Query: 451 ENAHNRQKLTETEL-------KFELLEKD 472
           +     QK+   E           LLEK+
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKE 545



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 90/435 (20%), Positives = 180/435 (41%), Gaps = 44/435 (10%)

Query: 58  EEKSKLLEKFSLVQKEYEGYEVESSLK--DASFEKEATEAQSLEATCEKLNRSNSELEDE 115
           E  SK   + +L QK+ +  +++S L   + S  +   E        +KL    SE+E +
Sbjct: 328 ESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETK 387

Query: 116 ILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERL 175
              L+ E K+ + +  E+++    +   I  L  +    + Q+ EA    K      E+ 
Sbjct: 388 YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK------EQR 441

Query: 176 KIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHI 235
           +++ +  +++  Q+ + Q +L +  E  KE+V+   + +   + +K   ++    ++S  
Sbjct: 442 QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501

Query: 236 KTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNA 295
             L E    ++     +G+      NLE  +    EN + L+               L A
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK----------EREDLYA 551

Query: 296 SLKTLEGERNQIYIQLSEVDKTKEE----LTEHIKNLQTEQASLQSENTHFENENQKLQQ 351
            ++  EGE   +  QL E + T +E    LTE +KN Q+E      EN H + + QK   
Sbjct: 552 KIQAGEGE-TAVLNQLQEKNHTLQEQVTQLTEKLKN-QSESHKQAQENLHDQVQEQKAHL 609

Query: 352 KLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATE-------------- 397
           +        Q+  + L   +    +   E +EK+S++D +I   TE              
Sbjct: 610 RAA------QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663

Query: 398 ELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQ 457
           +L+ +   A++  ++ ++ ++    Q+     K  D        E +L + +++     Q
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723

Query: 458 KLTETELKFELLEKD 472
           K  E E + + LE D
Sbjct: 724 KTEELEGQIKKLEAD 738



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 91/447 (20%), Positives = 183/447 (40%), Gaps = 67/447 (14%)

Query: 59   EKSKLLEKFSLVQKEYEGYEVESSLKDAS--FEKEATEAQS----LEATCEKLNRSNSEL 112
            EK  L+ + S V+ +    +V  SLK++   FEKE  + ++    LE TC++L       
Sbjct: 847  EKEALMTELSTVKDKLS--KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ 904

Query: 113  EDEILCLEKELKEEKSKHSE-----------QDELMADISKRIQSLEDESKSLKSQVAEA 161
             +  L  +KELK+   K  E             E +      ++  E E + L+  + E 
Sbjct: 905  MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964

Query: 162  KMTF----KIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTF 217
            K +     K  +  +  LKIA+       ++LQ+   Q  QE    KE++S L      +
Sbjct: 965  KQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN---Y 1021

Query: 218  EDSKVHAEQVLND---KESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGA 274
            E S+   +Q+ +D   +ES +    + L  +++  ++  ED+  + N             
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN------------- 1068

Query: 275  YLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQ-----LSEVDKTKEELTEHIKNLQ 329
                   G   KLI   K   +    +  + +  +Q     L ++ K K    + + N +
Sbjct: 1069 -----QIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123

Query: 330  TEQASLQSENTHFENENQKLQQKLKV--MTELYQENEMKLHRKLTVEENYRLEKEEKLSK 387
            ++ A ++      E E  KL ++LK   +  + +   +K  ++L +++  +LE + K   
Sbjct: 1124 SKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ--KLELQGKADS 1181

Query: 388  VDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIIS-----------HEKKAHDNWL 436
            +   +       +  + + K  EEEL++     + ++ S           HE+      +
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241

Query: 437  AARNAERNLNDLRKENAHNRQKLTETE 463
                   NL  ++KE   ++++++E E
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELE 1268



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 96/478 (20%), Positives = 203/478 (42%), Gaps = 60/478 (12%)

Query: 46  EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKL 105
           E++L      L E++    EK    +++    +++ S  +   +++ T +  L+   +K 
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486

Query: 106 NRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTF 165
            + + E +        +L+E ++   +    + D  ++IQ+LE       + + ++K   
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE-------ALLQKSKENI 539

Query: 166 KIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAE 225
            + +   E L   I+    E + L     QL ++    +EQV++L ++     +S   A+
Sbjct: 540 SLLEKEREDLYAKIQAGEGETAVL----NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 226 QVLND----KESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPK 281
           + L+D    +++H++   +R+L ++          T  + L  ++N   E  + LD   K
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLE----------TSVNELNSQLNESKEKVSQLDIQIK 645

Query: 282 GALKKLIHA--------AKLNASLKTLEG-------ERNQIYIQLSEV-----DKTK--E 319
              + L+ A        A L   L T +        E N+I  QL +V     DK +   
Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705

Query: 320 ELTEHIKNLQTEQASLQSENTHFENENQKLQ--------QKLKVMTELYQENEMKLHRKL 371
           +L  H+K  + +  SL+ +    E + +KL+         K + + +L Q+ ++    +L
Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765

Query: 372 TVEE-NYRLEKEEKL-SKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEK 429
              E + +LE E+++ S     +   +E LE+ +++    EE  E+ I     + +S E 
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--EKQILKQDFETLSQET 823

Query: 430 KAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREH 487
           K     L  R  +  + +L+K        +TE     + L K   +L    + F +E+
Sbjct: 824 KIQHEELNNR-IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 97/437 (22%), Positives = 175/437 (40%), Gaps = 55/437 (12%)

Query: 45   REKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEK 104
            +++  + + S L E K K L   SL QK  E       L+  S E +A++ Q+L+   ++
Sbjct: 700  KQEHCSQLESHLKEYKEKYL---SLEQKTEELEGQIKKLEADSLEVKASKEQALQ-DLQQ 755

Query: 105  LNRSNSELEDEILCLEKELKEEKSKHS-------EQDELMADISKRIQSLEDESKSLKSQ 157
              + N++LE     L K+L+ EK   S       ++ E +  I +++   E+E + LK  
Sbjct: 756  QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815

Query: 158  VAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSE----LNKQ 213
                    KI     E L   I+  + E  +++  ++ L+ E    K+++S+    L   
Sbjct: 816  FETLSQETKI---QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872

Query: 214  KVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENG 273
            K  FE      +  + D E   K L  +L         +   + +   L+  +  E E  
Sbjct: 873  KSEFEKENQKGKAAILDLEKTCKELKHQL------QVQMENTLKEQKELKKSLEKEKEAS 926

Query: 274  AYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQA 333
              L        ++LI A     +LK  E E  Q+   ++E+ ++ E+  + I+ LQ E  
Sbjct: 927  HQLKLELNSMQEQLIQAQN---TLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983

Query: 334  SLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKIS 393
                + T  EN                     KL ++LT        ++EK+S +     
Sbjct: 984  IAVLQKTELEN---------------------KLQQQLTQAAQELAAEKEKISVLQNNYE 1022

Query: 394  HATEELETYRKRAKDLEEELERTIHSYQGQIISHEKK---AHDNWLAARNAERNLNDLRK 450
             + E  +  +      E EL  T    +  + S E+K   A ++ ++ RN   N N L +
Sbjct: 1023 KSQETFKQLQSDFYGRESELLAT----RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078

Query: 451  ENAHNRQKLTETELKFE 467
            E    +  L +   K E
Sbjct: 1079 ELKTAKATLEQDSAKKE 1095



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 75/309 (24%), Positives = 145/309 (46%), Gaps = 23/309 (7%)

Query: 46   EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKL 105
            E+KL+L    LI  ++++  +  L+Q   E    +++L+  S +KE    Q L+  C+ L
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQ---ELKTAKATLEQDSAKKE----QQLQERCKAL 1105

Query: 106  NRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTF 165
                 +++ E    EKEL  EKSK +E +E+     K I  L +E KS K +  +     
Sbjct: 1106 Q----DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161

Query: 166  KIFQ--MNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVH 223
            K  +  + +++L++  K    + +  QE + Q + + +V KE+  EL K+ +  +++K+H
Sbjct: 1162 KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE-EELKKEFIE-KEAKLH 1219

Query: 224  AEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGA 283
            +E  + +KE  +K   E   K+      L E++     ++ E  S     + L+      
Sbjct: 1220 SE--IKEKEVGMKKHEENEAKLTMQITALNENL---GTVKKEWQSSQRRVSELEKQTDDL 1274

Query: 284  LKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFE 343
              ++   A L A+++  + ER  +  +  + +   E+L   +  LQ +  +  +      
Sbjct: 1275 RGEI---AVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG 1331

Query: 344  NENQKLQQK 352
             ENQ LQ K
Sbjct: 1332 RENQSLQIK 1340


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.131    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,202,338
Number of Sequences: 37866
Number of extensions: 2512508
Number of successful extensions: 28048
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 515
Number of HSP's successfully gapped in prelim test: 1844
Number of HSP's that attempted gapping in prelim test: 12097
Number of HSP's gapped (non-prelim): 9407
length of query: 775
length of database: 18,247,518
effective HSP length: 110
effective length of query: 665
effective length of database: 14,082,258
effective search space: 9364701570
effective search space used: 9364701570
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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