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Search of human proteins with 126507091
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo
sapiens]
(1088 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens] 2243 0.0
gi|4758666 LATS homolog 1 [Homo sapiens] 1033 0.0
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 389 e-107
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 383 e-106
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 275 1e-73
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 275 1e-73
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 264 4e-70
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 262 1e-69
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 256 6e-68
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 249 1e-65
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 249 1e-65
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 249 1e-65
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 248 3e-65
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 245 1e-64
gi|32698688 citron [Homo sapiens] 228 3e-59
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 222 1e-57
gi|148727255 microtubule associated serine/threonine kinase fami... 219 8e-57
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 214 4e-55
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 213 8e-55
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 213 1e-54
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 212 1e-54
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 212 2e-54
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 209 1e-53
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 209 1e-53
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 208 2e-53
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 206 7e-53
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 206 1e-52
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 203 8e-52
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 202 1e-51
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 202 2e-51
>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
Length = 1088
Score = 2243 bits (5813), Expect = 0.0
Identities = 1088/1088 (100%), Positives = 1088/1088 (100%)
Query: 1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ 60
MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
Sbjct: 1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ 60
Query: 61 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA 120
QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
Sbjct: 61 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA 120
Query: 121 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF 180
LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
Sbjct: 121 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF 180
Query: 181 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE 240
ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
Sbjct: 181 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE 240
Query: 241 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA 300
AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
Sbjct: 241 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA 300
Query: 301 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY 360
GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
Sbjct: 301 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY 360
Query: 361 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG 420
ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
Sbjct: 361 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG 420
Query: 421 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA 480
KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
Sbjct: 421 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA 480
Query: 481 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM 540
AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
Sbjct: 481 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM 540
Query: 541 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY 600
EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
Sbjct: 541 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY 600
Query: 601 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR 660
AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
Sbjct: 601 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR 660
Query: 661 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL 720
AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
Sbjct: 661 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL 720
Query: 721 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE 780
AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
Sbjct: 721 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE 780
Query: 781 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD 840
SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
Sbjct: 781 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD 840
Query: 841 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG 900
LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
Sbjct: 841 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG 900
Query: 901 VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG 960
VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
Sbjct: 901 VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG 960
Query: 961 RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK 1020
RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK
Sbjct: 961 RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK 1020
Query: 1021 AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT 1080
AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT
Sbjct: 1021 AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT 1080
Query: 1081 EGCQPVYV 1088
EGCQPVYV
Sbjct: 1081 EGCQPVYV 1088
>gi|4758666 LATS homolog 1 [Homo sapiens]
Length = 1130
Score = 1033 bits (2670), Expect = 0.0
Identities = 594/1149 (51%), Positives = 729/1149 (63%), Gaps = 105/1149 (9%)
Query: 1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ 60
MRPKTFPA+ Y+ +SRQ LQEIRE L+ SK S + A+ SK +T
Sbjct: 13 MRPKTFPASNYTVSSRQMLQEIRESLRNLSKPS-----------DAAKAEHNMSKMSTED 61
Query: 61 QQQMRATPKFGPYQKALREIRYSLLPFANESGTS-AAAEVNRQMLQELVNAGCDQEMAGR 119
+Q+R PKFG + KAL+EIR SLLPFANE+ +S + +EVN QMLQ+L AG D++M +
Sbjct: 62 PRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQ 121
Query: 120 ALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQ---TSPGKGLMPTPVTRRPSFEGT 176
AL++T +RSIEAA+E+ISKM Y DPR EQ+ + S G + V R+ S++G+
Sbjct: 122 ALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGS 181
Query: 177 GDSF------------ASYHQLS-------GTPYEGPSFGA------DGPTALEEMPRPY 211
+S +YH S G P G A + P P
Sbjct: 182 KESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQ 241
Query: 212 VDYLFP------------GVGPHGPGHQHQHPPKGYGASVEAAGAHF---PLQGAHYGRP 256
V + P G P P + K Y ++E + P G P
Sbjct: 242 VRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYP 301
Query: 257 HLLVPGEPLG------YGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGL-------- 302
+ P+ G+ P + ++ + P+ G G G
Sbjct: 302 PPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQN 361
Query: 303 AFPPPAAGLYVPHPHHKQA--GPAAHQLHVLGSRS-QVFASDSPPQSLLTPSRNSLNVDL 359
P P P+ A G + L GS + + + S PQS++ P+RNS N++L
Sbjct: 362 VVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMEL 421
Query: 360 YELGSTSVQ-QWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGP 418
Y + +Q WP ++ A S G E P ++P+ PV R+NSFN+ P
Sbjct: 422 YNISVPGLQTNWPQSSSAPAQSSPSSGHEIP-----TWQPNIPV--RSNSFNN--PLGNR 472
Query: 419 PGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPA 478
+ S P+ TVTA+T A I PVKS+RVL+PE QTA+ P+HP+W+P P P+P
Sbjct: 473 ASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPF 532
Query: 479 PAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCA 538
P + +A P+ + PPPPYPKHLL ++ S +S+
Sbjct: 533 PEGTASNVTVMPPVA-------------EAPNYQGPPPPYPKHLLHQNPSVP-PYESISK 578
Query: 539 GMEQSLRAGPNEPEGGDKSRKSAKG-DKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSY 597
++ + P E D+S KS + D G K+KKQI TSP+ VRKN +DEE+RESRI+SY
Sbjct: 579 PSKEDQPSLPKE----DESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSY 634
Query: 598 SPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNR 657
SP AFKFFMEQHVENV+K++QQ+++R+ QLE EM + GL + Q+QMRK+L QKESNY R
Sbjct: 635 SPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIR 694
Query: 658 LKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAER 717
LKRAKMDKSMFVKIKTLGIGAFGEVCLA KVDT ALYA KTLRKKDVL RNQVAHVKAER
Sbjct: 695 LKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAER 754
Query: 718 DILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTL 777
DILAEADNEWVV+LYYSFQDKD+LYFVMDYIPGGDMMSLLIRM +FPE LARFYIAELT
Sbjct: 755 DILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTC 814
Query: 778 AIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSME 837
A+ESVHKMGFIHRDIKPDNILID DGHIKLTDFGLCTGFRWTH+SKYYQ G H RQDSM+
Sbjct: 815 AVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMD 874
Query: 838 PSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWW 897
S+ W D S+CRCGDRLK LE+RA +QHQRCLAHSLVGTPNYIAPEVLLR GYTQLCDWW
Sbjct: 875 FSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWW 934
Query: 898 SVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADH 957
SVGVILFEMLVGQPPFLA TP ETQ+KVINW+ +LHIP Q KLSPEA DLI KLC +
Sbjct: 935 SVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPED 994
Query: 958 RLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEG 1017
RLG+NGAD++KAHPFF IDFSSD+R+Q A Y+P I+HP DTSNFDPVD + W+D +E
Sbjct: 995 RLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNE- 1053
Query: 1018 STKAWDTLTS--PNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSD 1075
DTL N KHPEHAFYEFTFRRFFDDNGYP+ PKP E ++ S+ + SD
Sbjct: 1054 EENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSE-QQSD 1112
Query: 1076 LVDQTEGCQ 1084
DQ G +
Sbjct: 1113 EDDQNTGSE 1121
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 389 bits (998), Expect = e-107
Identities = 194/443 (43%), Positives = 286/443 (64%), Gaps = 21/443 (4%)
Query: 603 KFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAK 662
K +E N+I ++++ R+ +LE M + GL + E++ R +KE+ + RLKR +
Sbjct: 25 KLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTR 84
Query: 663 MDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAE 722
+ F +K +G GAFGEV L K DT +YAMK LRK D+L + QVAH++AERDIL E
Sbjct: 85 LGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE 144
Query: 723 ADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESV 782
AD WVVK++YSFQDK +LY +M+++PGGDMM+LL++ + E +FYI+E LAI+++
Sbjct: 145 ADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAI 204
Query: 783 HKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLW 842
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y+ +H PSD
Sbjct: 205 HQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTH-----NPPSDF- 258
Query: 843 DDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI 902
N + +T K+++R LA+S VGTP+YIAPEV ++ GY +LCDWWS+GVI
Sbjct: 259 -SFQNMNSKRKAETW-----KKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 312
Query: 903 LFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRN 962
++EML+G PPF + TP ET KV+NW+ TL P +V +S +A+DLI + C +++R+G +
Sbjct: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNS 372
Query: 963 GADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAW 1022
G +++K HPFF +D+ IR++PA I DTSNFD E +
Sbjct: 373 GVEEIKGHPFFEGVDW-EHIRERPAAIPIEIKSIDDTSNFDDFPESD--------ILQPV 423
Query: 1023 DTLTSPNNKHPEHAFYEFTFRRF 1045
T P+ K + F +T++RF
Sbjct: 424 PNTTEPDYKSKDWVFLNYTYKRF 446
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 383 bits (983), Expect = e-106
Identities = 196/443 (44%), Positives = 287/443 (64%), Gaps = 18/443 (4%)
Query: 603 KFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAK 662
K +E N+I ++++ R+ +LE+ M + GL + E+ R +KE+ + RLKR +
Sbjct: 24 KVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTR 83
Query: 663 MDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAE 722
+ F +K +G GAFGEV L K DT +YAMK LRK D+L + QV H++AERDIL E
Sbjct: 84 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 143
Query: 723 ADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESV 782
AD+ WVVK++YSFQDK +LY +M+++PGGDMM+LL++ + E +FYIAE LAI+S+
Sbjct: 144 ADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 203
Query: 783 HKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLW 842
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y+ +H PSD
Sbjct: 204 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNH-----SLPSDFT 258
Query: 843 DDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI 902
N + + K+++R LA S VGTP+YIAPEV ++ GY +LCDWWS+GVI
Sbjct: 259 FQNMNSK-------RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 311
Query: 903 LFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRN 962
++EML+G PPF + TP ET KV+NW+ TL P +V +S +A+DLI + CC +HR+G
Sbjct: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
Query: 963 GADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAW 1022
G +++K++ FF +D+ IR++PA I DTSNFD E P +D + T A
Sbjct: 372 GVEEIKSNSFFEGVDW-EHIRERPAAISIEIKSIDDTSNFD----EFPESDILK-PTVAT 425
Query: 1023 DTLTSPNNKHPEHAFYEFTFRRF 1045
+ K+ + F +T++RF
Sbjct: 426 SNHPETDYKNKDWVFINYTYKRF 448
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 275 bits (704), Expect = 1e-73
Identities = 149/359 (41%), Positives = 214/359 (59%), Gaps = 54/359 (15%)
Query: 656 NRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKA 715
+++K+ ++ + F +K +G GAFGEV + + ++AMK L K ++L R + A +
Sbjct: 65 SKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFRE 124
Query: 716 ERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEHLARFYIAE 774
ERD+L DN+W+ L+Y+FQD ++LY VMDY GGD+++LL + E PE +ARFY+AE
Sbjct: 125 ERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAE 184
Query: 775 LTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQD 834
+ +AI+SVH++ ++HRDIKPDNIL+D++GHI+L DFG C
Sbjct: 185 MVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL------------------ 226
Query: 835 SMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLR----KG- 889
ME + V+ VGTP+YI+PE+L KG
Sbjct: 227 -MEDGTVQSSVA---------------------------VGTPDYISPEILQAMEDGKGR 258
Query: 890 YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQV-KLSPEARDLI 948
Y CDWWS+GV ++EML G+ PF A + ET K++N + PAQV +S A+DLI
Sbjct: 259 YGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLI 318
Query: 949 TKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1007
+L CS +HRLG+NG +D K HPFFS ID+ +IR APY+P +S P DTSNFD D+
Sbjct: 319 RRLICSREHRLGQNGIEDFKKHPFFSGIDW-DNIRNCEAPYIPEVSSPTDTSNFDVDDD 376
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 275 bits (704), Expect = 1e-73
Identities = 149/359 (41%), Positives = 214/359 (59%), Gaps = 54/359 (15%)
Query: 656 NRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKA 715
+++K+ ++ + F +K +G GAFGEV + + ++AMK L K ++L R + A +
Sbjct: 65 SKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFRE 124
Query: 716 ERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEHLARFYIAE 774
ERD+L DN+W+ L+Y+FQD ++LY VMDY GGD+++LL + E PE +ARFY+AE
Sbjct: 125 ERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAE 184
Query: 775 LTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQD 834
+ +AI+SVH++ ++HRDIKPDNIL+D++GHI+L DFG C
Sbjct: 185 MVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL------------------ 226
Query: 835 SMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLR----KG- 889
ME + V+ VGTP+YI+PE+L KG
Sbjct: 227 -MEDGTVQSSVA---------------------------VGTPDYISPEILQAMEDGKGR 258
Query: 890 YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQV-KLSPEARDLI 948
Y CDWWS+GV ++EML G+ PF A + ET K++N + PAQV +S A+DLI
Sbjct: 259 YGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLI 318
Query: 949 TKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1007
+L CS +HRLG+NG +D K HPFFS ID+ +IR APY+P +S P DTSNFD D+
Sbjct: 319 RRLICSREHRLGQNGIEDFKKHPFFSGIDW-DNIRNCEAPYIPEVSSPTDTSNFDVDDD 376
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 264 bits (674), Expect = 4e-70
Identities = 143/357 (40%), Positives = 206/357 (57%), Gaps = 54/357 (15%)
Query: 658 LKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAER 717
+K ++ + F IK +G GAFGEV + +T +YAMK L K ++L R + A + ER
Sbjct: 66 VKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREER 125
Query: 718 DILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEHLARFYIAELT 776
D+L D +W+ L+Y+FQD++ LY VMDY GGD+++LL + E PE +ARFYI E+
Sbjct: 126 DVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185
Query: 777 LAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSM 836
LAI+S+H++ ++HRDIKPDN+L+D++GHI+L DFG C + D
Sbjct: 186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCL---------------KMNDDGT 230
Query: 837 EPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVL--LRKG---YT 891
S + VGTP+YI+PE+L + G Y
Sbjct: 231 VQSSV-------------------------------AVGTPDYISPEILQAMEDGMGKYG 259
Query: 892 QLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQV-KLSPEARDLITK 950
CDWWS+GV ++EML G+ PF A + ET K++N E P+ V +S EA+DLI +
Sbjct: 260 PECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQR 319
Query: 951 LCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1007
L CS + RLG+NG +D K H FF +++ +IR APY+P +S P DTSNFD D+
Sbjct: 320 LICSRERRLGQNGIEDFKKHAFFEGLNW-ENIRNLEAPYIPDVSSPSDTSNFDVDDD 375
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 262 bits (669), Expect = 1e-69
Identities = 141/359 (39%), Positives = 207/359 (57%), Gaps = 54/359 (15%)
Query: 656 NRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKA 715
+++K ++ + F +K +G GAFGEV + + DT ++AMK L K ++L R + A +
Sbjct: 59 SKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFRE 118
Query: 716 ERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEHLARFYIAE 774
ERD+L + D+ WV L+Y+FQD++ LY VMDY GGD+++LL R E P LA+FY+AE
Sbjct: 119 ERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAE 178
Query: 775 LTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQD 834
+ LAI S+H++G++HRD+KPDN+L+D++GHI+L DFG C + +
Sbjct: 179 MVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCL---------------RLNTN 223
Query: 835 SMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVL--LRKG--- 889
M S + VGTP+YI+PE+L + +G
Sbjct: 224 GMVDSSV-------------------------------AVGTPDYISPEILQAMEEGKGH 252
Query: 890 YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSP-EARDLI 948
Y CDWWS+GV +E+L G+ PF A + ET K++N E+ L P V P A+DLI
Sbjct: 253 YGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLI 312
Query: 949 TKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1007
+L C + RLGR G DD + HPFF +D+ + APY+P + PMDTSNFD D+
Sbjct: 313 RQLLCRQEERLGRGGLDDFRNHPFFEGVDWER-LASSTAPYIPELRGPMDTSNFDVDDD 370
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 256 bits (655), Expect = 6e-68
Identities = 145/374 (38%), Positives = 210/374 (56%), Gaps = 52/374 (13%)
Query: 640 EQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTL 699
+ + + L + + N+++ +M + +K +G GAFGEV L T +YAMK L
Sbjct: 48 KNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLL 107
Query: 700 RKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIR 759
K +++ R+ A ERDI+A A++ WVV+L+Y+FQD LY VM+Y+PGGD+++L+
Sbjct: 108 SKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN 167
Query: 760 MEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWT 819
+V PE ARFY AE+ LA++++H MGFIHRD+KPDN+L+D GH+KL DFG C
Sbjct: 168 YDV-PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM--- 223
Query: 820 HNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNY 879
K VR D + VGTP+Y
Sbjct: 224 ------NKEGMVRCD-------------------------------------TAVGTPDY 240
Query: 880 IAPEVLLRKG----YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIP 935
I+PEVL +G Y + CDWWSVGV L+EMLVG PF A + T K++N +N+L P
Sbjct: 241 ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300
Query: 936 AQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFS-SDIRKQPAPYVPTIS 994
+S EA++LI + RLGRNG +++K H FF ++ +R AP VP +S
Sbjct: 301 DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS 360
Query: 995 HPMDTSNFDPVDEE 1008
+DTSNFD ++E+
Sbjct: 361 SDIDTSNFDDLEED 374
Score = 31.6 bits (70), Expect = 4.3
Identities = 23/104 (22%), Positives = 48/104 (46%), Gaps = 3/104 (2%)
Query: 559 KSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQ 618
K K ++ ++K + + + + + D + ++S+ K K ME V+N+ +
Sbjct: 718 KKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLE 777
Query: 619 QKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAK 662
Q+ N+RL L+ E+ E + ++ + Q + N L AK
Sbjct: 778 QESNKRLLLQNELKTQAF---EADNLKGLEKQMKQEINTLLEAK 818
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 249 bits (636), Expect = 1e-65
Identities = 155/463 (33%), Positives = 230/463 (49%), Gaps = 76/463 (16%)
Query: 625 LQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCL 684
L + QE+ + L A+ + + L E RLK ++ + F +K +G GAF EV +
Sbjct: 30 LGVHQELGASEL--AQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAV 87
Query: 685 ACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFV 744
T +YAMK + K D+L R +V+ + ERD+L D W+ +L+++FQD++ LY V
Sbjct: 88 VKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLV 147
Query: 745 MDYIPGGDMMSLLIRM-EVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDG 803
M+Y GGD+++LL + E P +ARFY+AE+ +AI+SVH++G++HRDIKPDNIL+D G
Sbjct: 148 MEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCG 207
Query: 804 HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARK 863
HI+L DFG C L+ RA
Sbjct: 208 HIRLADFGSC-------------------------------------------LKLRADG 224
Query: 864 QHQRCLAHSLVGTPNYIAPEVLLRKG-------YTQLCDWWSVGVILFEMLVGQPPFLAP 916
+ +A VGTP+Y++PE+L G Y CDWW++GV +EM GQ PF A
Sbjct: 225 TVRSLVA---VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYAD 281
Query: 917 TPTETQLKVINWENTLHIPAQVKLSP-EARDLITKLCCSADHRLGRNGADDLKAHPFFSA 975
+ ET K+++++ L +P + P EARD I +L C + RLGR GA D + HPFF
Sbjct: 282 STAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG 341
Query: 976 IDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEH 1035
+D+ +R P+ P DT NFD V E A +TL+ P
Sbjct: 342 LDWDG-LRDSVPPFTPDFEGATDTCNFDLV----------EDGLTAMETLSDIREGAPLG 390
Query: 1036 AFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVD 1078
F GY + C +E +LE+ L++
Sbjct: 391 VHLPFV--------GYSYSCMALRDSEVPGPTPMELEAEQLLE 425
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 249 bits (636), Expect = 1e-65
Identities = 155/463 (33%), Positives = 230/463 (49%), Gaps = 76/463 (16%)
Query: 625 LQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCL 684
L + QE+ + L A+ + + L E RLK ++ + F +K +G GAF EV +
Sbjct: 30 LGVHQELGASEL--AQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAV 87
Query: 685 ACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFV 744
T +YAMK + K D+L R +V+ + ERD+L D W+ +L+++FQD++ LY V
Sbjct: 88 VKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLV 147
Query: 745 MDYIPGGDMMSLLIRM-EVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDG 803
M+Y GGD+++LL + E P +ARFY+AE+ +AI+SVH++G++HRDIKPDNIL+D G
Sbjct: 148 MEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCG 207
Query: 804 HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARK 863
HI+L DFG C L+ RA
Sbjct: 208 HIRLADFGSC-------------------------------------------LKLRADG 224
Query: 864 QHQRCLAHSLVGTPNYIAPEVLLRKG-------YTQLCDWWSVGVILFEMLVGQPPFLAP 916
+ +A VGTP+Y++PE+L G Y CDWW++GV +EM GQ PF A
Sbjct: 225 TVRSLVA---VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYAD 281
Query: 917 TPTETQLKVINWENTLHIPAQVKLSP-EARDLITKLCCSADHRLGRNGADDLKAHPFFSA 975
+ ET K+++++ L +P + P EARD I +L C + RLGR GA D + HPFF
Sbjct: 282 STAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG 341
Query: 976 IDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEH 1035
+D+ +R P+ P DT NFD V E A +TL+ P
Sbjct: 342 LDWDG-LRDSVPPFTPDFEGATDTCNFDLV----------EDGLTAMETLSDIREGAPLG 390
Query: 1036 AFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVD 1078
F GY + C +E +LE+ L++
Sbjct: 391 VHLPFV--------GYSYSCMALRDSEVPGPTPMELEAEQLLE 425
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 249 bits (636), Expect = 1e-65
Identities = 138/374 (36%), Positives = 209/374 (55%), Gaps = 52/374 (13%)
Query: 640 EQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTL 699
+ + + L + E +++ +M + +K +G GAFGEV L + +YAMK L
Sbjct: 64 KNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLL 123
Query: 700 RKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIR 759
K +++ R+ A ERDI+A A++ WVV+L+Y+FQD LY VM+Y+PGGD+++L+
Sbjct: 124 SKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN 183
Query: 760 MEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWT 819
+V PE A+FY AE+ LA++++H MG IHRD+KPDN+L+D GH+KL DFG C
Sbjct: 184 YDV-PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKM--- 239
Query: 820 HNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNY 879
D+ C + VGTP+Y
Sbjct: 240 -----------------------DETGMVHC--------------------DTAVGTPDY 256
Query: 880 IAPEVLLRKG----YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIP 935
I+PEVL +G Y + CDWWSVGV L+EMLVG PF A + T K+++ +N+L P
Sbjct: 257 ISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP 316
Query: 936 AQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSD-IRKQPAPYVPTIS 994
++S A++LI + RLGRNG ++++ HPFF + D IR+ AP VP +S
Sbjct: 317 EDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELS 376
Query: 995 HPMDTSNFDPVDEE 1008
+D+SNFD ++++
Sbjct: 377 SDIDSSNFDDIEDD 390
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 248 bits (632), Expect = 3e-65
Identities = 142/392 (36%), Positives = 211/392 (53%), Gaps = 58/392 (14%)
Query: 625 LQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCL 684
L + QE+ + L A+ + + L E RLK ++ + F +K +G GAF EV +
Sbjct: 30 LGVHQELGASEL--AQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAV 87
Query: 685 ACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFV 744
T +YAMK + K D+L R +V+ + ERD+L D W+ +L+++FQD++ LY V
Sbjct: 88 VKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLV 147
Query: 745 MDYIPGGDMMSLLIRM-EVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDG 803
M+Y GGD+++LL + E P +ARFY+AE+ +AI+SVH++G++HRDIKPDNIL+D G
Sbjct: 148 MEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCG 207
Query: 804 HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARK 863
HI+L DFG C L+ RA
Sbjct: 208 HIRLADFGSC-------------------------------------------LKLRADG 224
Query: 864 QHQRCLAHSLVGTPNYIAPEVLLRKG-------YTQLCDWWSVGVILFEMLVGQPPFLAP 916
+ +A VGTP+Y++PE+L G Y CDWW++GV +EM GQ PF A
Sbjct: 225 TVRSLVA---VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYAD 281
Query: 917 TPTETQLKVINWENTLHIPAQVKLSP-EARDLITKLCCSADHRLGRNGADDLKAHPFFSA 975
+ ET K+++++ L +P + P EARD I +L C + RLGR GA D + HPFF
Sbjct: 282 STAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG 341
Query: 976 IDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1007
+D+ +R P+ P DT NFD V++
Sbjct: 342 LDWDG-LRDSVPPFTPDFEGATDTCNFDLVED 372
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 245 bits (626), Expect = 1e-64
Identities = 135/360 (37%), Positives = 198/360 (55%), Gaps = 56/360 (15%)
Query: 657 RLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAE 716
RLK ++ + F +K +G GAF EV + T +YAMK + K D+L R +V+ + E
Sbjct: 70 RLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREE 129
Query: 717 RDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRM-EVFPEHLARFYIAEL 775
RD+L D W+ +L+++FQD++ LY VM+Y GGD+++LL + E P +ARFY+AE+
Sbjct: 130 RDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEI 189
Query: 776 TLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDS 835
+AI+SVH++G++HRDIKPDNIL+D GHI+L DFG C
Sbjct: 190 VMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSC---------------------- 227
Query: 836 MEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKG------ 889
L+ RA + +A VGTP+Y++PE+L G
Sbjct: 228 ---------------------LKLRADGTVRSLVA---VGTPDYLSPEILQAVGGGPGTG 263
Query: 890 -YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSP-EARDL 947
Y CDWW++GV +EM GQ PF A + ET K+++++ L +P + P EARD
Sbjct: 264 SYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDF 323
Query: 948 ITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1007
I +L C + RLGR GA D + HPFF +D+ +R P+ P DT NFD V++
Sbjct: 324 IQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDG-LRDSVPPFTPDFEGATDTCNFDLVED 382
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 228 bits (580), Expect = 3e-59
Identities = 138/349 (39%), Positives = 192/349 (55%), Gaps = 58/349 (16%)
Query: 674 LGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYY 733
+G G F EV + + T +YAMK ++KK +L + QV+ + ER+IL+ + + W+ +L Y
Sbjct: 103 VGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQY 162
Query: 734 SFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEHLARFYIAELTLAIESVHKMGFIHRDI 792
+FQDK+ LY VM+Y PGGD++SLL R E E+L +FY+AEL LA+ SVH MG++HRDI
Sbjct: 163 AFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDI 222
Query: 793 KPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGD 852
KP+NIL+D GHIKL DF GS + +S
Sbjct: 223 KPENILVDRTGHIKLVDF-----------------GSAAKMNS----------------- 248
Query: 853 RLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLL------RKGYTQLCDWWSVGVILFEM 906
++ A +GTP+Y+APEVL + Y CDWWSVGVI +EM
Sbjct: 249 ------------NKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEM 296
Query: 907 LVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADD 966
+ G+ PF T T ++N++ L P K+S + DLI L C RL G
Sbjct: 297 IYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEG--- 353
Query: 967 LKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDAS 1015
L HPFFS ID+ ++IR P P+VPT+ DTSNFD E++ W +S
Sbjct: 354 LCCHPFFSKIDW-NNIRNSPPPFVPTLKSDDDTSNFDE-PEKNSWVSSS 400
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 222 bits (566), Expect = 1e-57
Identities = 142/412 (34%), Positives = 214/412 (51%), Gaps = 39/412 (9%)
Query: 660 RAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDI 719
R K +S F IK + GA+G V L DT +A+K + K++++ RNQ+ V ERDI
Sbjct: 359 RRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDI 418
Query: 720 LAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAI 779
L A+N +VV ++ SF+ + L VM+Y+ GGD +LL M P +AR Y AE LA+
Sbjct: 419 LTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLAL 478
Query: 780 ESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPS 839
E +H G +HRD+KPDN+LI GHIKLTDFGL + + Y+ H+ +D+ E
Sbjct: 479 EYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYE--GHIEKDAREFI 536
Query: 840 DLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSV 899
D + GTP YIAPEV+ R+GY + DWW++
Sbjct: 537 D------------------------------KQVCGTPEYIAPEVIFRQGYGKPVDWWAM 566
Query: 900 GVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSAD-HR 958
GV+L+E LVG PF TP E +V++ + + L +A+DLIT+L + R
Sbjct: 567 GVVLYEFLVGCVPFFGDTPEELFGQVVS-DEIMWPEGDEALPADAQDLITRLLRQSPLDR 625
Query: 959 LGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGS 1018
LG G ++K HPFF A+D++ +R + A +VP + DTS FD E + +
Sbjct: 626 LGTGGTHEVKQHPFFLALDWAGLLRHK-AEFVPQLEAEDDTSYFDTRSERYRHLGSEDDE 684
Query: 1019 TKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSD 1070
T ++ T + P+ + F + + + + P P+ AE S +E +
Sbjct: 685 TNDEESST----EIPQFSSCSHRFSKVYSSSEFLAVQPTPTFAERSFSEDRE 732
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 219 bits (559), Expect = 8e-57
Identities = 135/361 (37%), Positives = 192/361 (53%), Gaps = 43/361 (11%)
Query: 653 SNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAH 712
SN + R K +S F IK + GA+G V ++ +AMK + K++++ RNQ+
Sbjct: 366 SNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQ 425
Query: 713 VKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYI 772
ERDIL A+N +VV +Y SF+ + L VM+Y+ GGD +L+ M P +AR Y
Sbjct: 426 AFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYF 485
Query: 773 AELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVR 832
AE LA+E +H G +HRD+KPDN+L+ GHIKLTDFGL + + Y+ H+
Sbjct: 486 AETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYE--GHIE 543
Query: 833 QDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQ 892
+D+ E L + GTP YIAPEV+LR+GY +
Sbjct: 544 KDARE------------------------------FLDKQVCGTPEYIAPEVILRQGYGK 573
Query: 893 LCDWWSVGVILFEMLVGQPPFLAPTPTETQLKV----INWENTLHIPAQVKLSPEARDLI 948
DWW++G+IL+E LVG PF TP E +V INW P P+A+DLI
Sbjct: 574 PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP-----PPDAQDLI 628
Query: 949 TKLCCSAD-HRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1007
T L RLG GA ++K H FF ++D++S +R Q A ++P + DTS FD E
Sbjct: 629 TLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLR-QKAEFIPQLESEDDTSYFDTRSE 687
Query: 1008 E 1008
+
Sbjct: 688 K 688
Score = 37.0 bits (84), Expect = 0.10
Identities = 54/202 (26%), Positives = 68/202 (33%), Gaps = 32/202 (15%)
Query: 361 ELGST--SVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGP 418
ELG V+ P A LARR SLQ PG+E+ ++ P QP
Sbjct: 1882 ELGKVRRGVEPKPEALLARR-SLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRH 1940
Query: 419 PGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPA 478
P S+P P +TA + P P + P P+ +P P
Sbjct: 1941 PS----SIPPP----PLTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPK 1992
Query: 479 PAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCA 538
P A ++ GPD P PP KH RS S Q
Sbjct: 1993 PVAAHSESSSHKPRP--------------GPD---PGPPKTKH-PDRSLSSQKPSVGATK 2034
Query: 539 GME---QSLRAGPNEPEGGDKS 557
G E QSL E +G KS
Sbjct: 2035 GKEPATQSLGGSSREGKGHSKS 2056
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 214 bits (545), Expect = 4e-55
Identities = 129/350 (36%), Positives = 185/350 (52%), Gaps = 35/350 (10%)
Query: 668 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW 727
F IK + GA+G V L T +AMK + K++++ RNQ+ ERDIL A+N +
Sbjct: 512 FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 571
Query: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787
VV ++ SF K L VM+Y+ GGD +LL + P + R Y AE LA+E +H G
Sbjct: 572 VVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGI 631
Query: 788 IHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSN 847
+HRD+KPDN+LI GHIKLTDFGL + + Y+ H+ +D+ E
Sbjct: 632 VHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYE--GHIEKDARE---------- 679
Query: 848 CRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML 907
L + GTP YIAPEV+LR+GY + DWW++G+IL+E L
Sbjct: 680 --------------------FLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFL 719
Query: 908 VGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSAD-HRLGRNGADD 966
VG PF TP E +VI+ + + L P+A+DL +KL RLG A +
Sbjct: 720 VGCVPFFGDTPEELFGQVIS-DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYE 778
Query: 967 LKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASE 1016
+K HPFF+ +D++ +R Q A ++P + DTS FD E D+ +
Sbjct: 779 VKQHPFFTGLDWTGLLR-QKAEFIPQLESEDDTSYFDTRSERYHHMDSED 827
Score = 38.1 bits (87), Expect = 0.046
Identities = 52/189 (27%), Positives = 66/189 (34%), Gaps = 22/189 (11%)
Query: 220 GPHGPGHQH----QHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSF 275
GP P H H + P +GY + +A + + P VP P G G R S
Sbjct: 1261 GPGSPTHSHSLSPRSPTQGYRVTPDAVHS-VGGNSSQSSSPSSSVPSSPAGSGHTRPSSL 1319
Query: 276 QSKTPPETGGYASLPTKGQGGPPGAGLAF-----PPPAAGLYVPHP---HHKQAGPA-AH 326
P Y S K G P + LA PP A+ P P H QA P H
Sbjct: 1320 HGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLH 1379
Query: 327 QLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKP-- 384
LG + S PP+S L S +L + +R+ SL P
Sbjct: 1380 LSPPLGRQLSRPKSAEPPRSPLLKRVQSAE----KLAAALAASEKKLATSRKHSLDLPHS 1435
Query: 385 --GLEAPPR 391
E PPR
Sbjct: 1436 ELKKELPPR 1444
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 213 bits (542), Expect = 8e-55
Identities = 134/350 (38%), Positives = 194/350 (55%), Gaps = 59/350 (16%)
Query: 662 KMDKSMFVKIKTLGIGAFGEVCLACKV---DTHALYAMKTLRKKDVLNRNQVAHVKAERD 718
K D S F +K LG G+FG+V L K+ D LYAMK L+K + R++V K ERD
Sbjct: 62 KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKMERD 120
Query: 719 ILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLA 778
IL E ++ ++VKL+Y+FQ + LY ++D++ GGD+ + L + +F E +FY+AEL LA
Sbjct: 121 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 779 IESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEP 838
++ +H +G I+RD+KP+NIL+D +GHIKLTDFGL S E
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGL----------------------SKES 218
Query: 839 SDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWS 898
D H++ A+S GT Y+APEV+ R+G+TQ DWWS
Sbjct: 219 ID------------------------HEK-KAYSFCGTVEYMAPEVVNRRGHTQSADWWS 253
Query: 899 VGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADH 957
GV++FEML G PF ET ++ + L +P LSPEA+ L+ L + +
Sbjct: 254 FGVLMFEMLTGTLPFQGKDRKETMTMIL--KAKLGMPQ--FLSPEAQSLLRMLFKRNPAN 309
Query: 958 RLGR--NGADDLKAHPFFSAIDFSSDIRKQ-PAPYVPTISHPMDTSNFDP 1004
RLG +G +++K H FFS ID++ R++ P+ P P DT FDP
Sbjct: 310 RLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
Score = 88.2 bits (217), Expect = 4e-17
Identities = 82/331 (24%), Positives = 142/331 (42%), Gaps = 74/331 (22%)
Query: 674 LGIGAFGEVCLAC-KVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLY 732
+G+G++ VC C T+ +A+K + K R+ ++ +L + ++ L
Sbjct: 428 IGVGSYS-VCKRCIHKATNMEFAVKIIDKS---KRDPTEEIEI---LLRYGQHPNIITLK 480
Query: 733 YSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDI 792
+ D +Y V + + GG+++ ++R + F E A + +T +E +H G +HRD+
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 793 KPDNIL-IDLDGH---IKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNC 848
KP NIL +D G+ I++ DFG R
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLR------------------------------- 569
Query: 849 RCGDRLKTLEQRARKQHQRCLAHSLVGTP----NYIAPEVLLRKGYTQLCDWWSVGVILF 904
+ L+ TP N++APEVL R+GY CD WS+GV+L+
Sbjct: 570 --------------------AENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLY 609
Query: 905 EMLVGQPPFL---APTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGR 961
ML G PF TP E ++ + + +L +S A+DL++K+ H+ R
Sbjct: 610 TMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQ--R 667
Query: 962 NGADDLKAHPFFSAIDF--SSDIRKQPAPYV 990
A + HP+ D + +Q AP++
Sbjct: 668 LTAALVLRHPWIVHWDQLPQYQLNRQDAPHL 698
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 213 bits (541), Expect = 1e-54
Identities = 133/388 (34%), Positives = 199/388 (51%), Gaps = 72/388 (18%)
Query: 628 EQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACK 687
EQE K L +A+++ ++K ++ A +D+ F +IKTLG G+FG V L
Sbjct: 12 EQESVKEFLAKAKEDFLKKWESPAQNT------AHLDQ--FERIKTLGTGSFGRVMLVKH 63
Query: 688 VDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDY 747
+T YAMK L K+ V+ Q+ H E+ IL + ++VKL +SF+D +LY VM+Y
Sbjct: 64 KETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEY 123
Query: 748 IPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKL 807
+PGG+M S L R+ F E ARFY A++ L E +H + I+RD+KP+N+LID G+I++
Sbjct: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183
Query: 808 TDFGLC---TGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQ 864
TDFG G WT
Sbjct: 184 TDFGFAKRVKGRTWT--------------------------------------------- 198
Query: 865 HQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLK 924
L GTP Y+APE++L KGY + DWW++GV+++EM G PPF A P + K
Sbjct: 199 --------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250
Query: 925 VINWENTLHIPAQVKLSPEARDLITKLC-CSADHRLG--RNGADDLKAHPFFSAIDFSSD 981
+++ + P+ S + +DL+ L R G +NG +D+K H +F+ D+ +
Sbjct: 251 IVS--GKVRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 306
Query: 982 I-RKQPAPYVPTISHPMDTSNFDPVDEE 1008
RK AP++P P DTSNFD +EE
Sbjct: 307 YQRKVEAPFIPKFKGPGDTSNFDDYEEE 334
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
b [Homo sapiens]
Length = 741
Score = 212 bits (540), Expect = 1e-54
Identities = 141/387 (36%), Positives = 211/387 (54%), Gaps = 62/387 (16%)
Query: 625 LQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCL 684
L L+ E E E+ +++I S++ + K D S F +K LG G++G+V L
Sbjct: 27 LNLDVEPTTEDTAEEEEGVVKEI---DISHHVKEGFEKADPSQFELLKVLGQGSYGKVFL 83
Query: 685 ACKV---DTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSL 741
KV D LYAMK L+K + R++V K ERDILAE ++ ++VKL+Y+FQ + L
Sbjct: 84 VRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEVNHPFIVKLHYAFQTEGKL 142
Query: 742 YFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDL 801
Y ++D++ GGD+ + L + +F E +FY+AEL LA++ +H +G I+RD+KP+NIL+D
Sbjct: 143 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE 202
Query: 802 DGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRA 861
+GHIK+TDFGL S E D
Sbjct: 203 EGHIKITDFGL----------------------SKEAID--------------------- 219
Query: 862 RKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTET 921
H + A+S GT Y+APEV+ R+G+TQ DWWS GV++FEML G PF ET
Sbjct: 220 ---HDK-RAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKET 275
Query: 922 QLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADHRLGR--NGADDLKAHPFFSAIDF 978
++ + L +P LS EA+ L+ L + +RLG +G +++K HPFF ID+
Sbjct: 276 MALIL--KAKLGMPQ--FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDW 331
Query: 979 SSDIRKQ-PAPYVPTISHPMDTSNFDP 1004
++ RK+ P+ P + P DT +FDP
Sbjct: 332 NTLYRKEIKPPFKPAVGRPEDTFHFDP 358
Score = 85.1 bits (209), Expect = 3e-16
Identities = 77/311 (24%), Positives = 130/311 (41%), Gaps = 72/311 (23%)
Query: 674 LGIGAFGEVCLAC-KVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLY 732
+G+G++ VC C T YA+K + K R+ ++ +L + ++ L
Sbjct: 429 IGVGSYS-VCKRCVHKATDTEYAVKIIDKS---KRDPSEEIEI---LLRYGQHPNIITLK 481
Query: 733 YSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDI 792
+ D +Y VM+ + GG+++ ++R F E A + +T ++ +H G +HRD+
Sbjct: 482 DVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDL 541
Query: 793 KPDNILI-DLDG---HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNC 848
KP NIL D G I++ DFG R
Sbjct: 542 KPSNILYRDESGSPESIRVCDFGFAKQLR------------------------------- 570
Query: 849 RCGDRLKTLEQRARKQHQRCLAHSLVGTP----NYIAPEVLLRKGYTQLCDWWSVGVILF 904
+ L+ TP N++APEVL R+GY CD WS+G++L+
Sbjct: 571 --------------------AGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLY 610
Query: 905 EMLVGQPPFL---APTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGR 961
ML G PF TP E ++ + + L +S A+D+++K+ H+ R
Sbjct: 611 TMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQ--R 668
Query: 962 NGADDLKAHPF 972
A + HP+
Sbjct: 669 LTAMQVLKHPW 679
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
a [Homo sapiens]
Length = 733
Score = 212 bits (539), Expect = 2e-54
Identities = 134/350 (38%), Positives = 196/350 (56%), Gaps = 59/350 (16%)
Query: 662 KMDKSMFVKIKTLGIGAFGEVCLACKV---DTHALYAMKTLRKKDVLNRNQVAHVKAERD 718
K D S F +K LG G++G+V L KV D LYAMK L+K + R++V K ERD
Sbjct: 53 KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERD 111
Query: 719 ILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLA 778
ILAE ++ ++VKL+Y+FQ + LY ++D++ GGD+ + L + +F E +FY+AEL LA
Sbjct: 112 ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 779 IESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEP 838
++ +H +G I+RD+KP+NIL+D +GHIK+TDFGL S E
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL----------------------SKEA 209
Query: 839 SDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWS 898
D H + A+S GT Y+APEV+ R+G+TQ DWWS
Sbjct: 210 ID------------------------HDK-RAYSFCGTIEYMAPEVVNRRGHTQSADWWS 244
Query: 899 VGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADH 957
GV++FEML G PF ET ++ + L +P LS EA+ L+ L + +
Sbjct: 245 FGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQ--FLSGEAQSLLRALFKRNPCN 300
Query: 958 RLGR--NGADDLKAHPFFSAIDFSSDIRKQ-PAPYVPTISHPMDTSNFDP 1004
RLG +G +++K HPFF ID+++ RK+ P+ P + P DT +FDP
Sbjct: 301 RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDP 350
Score = 85.1 bits (209), Expect = 3e-16
Identities = 77/311 (24%), Positives = 130/311 (41%), Gaps = 72/311 (23%)
Query: 674 LGIGAFGEVCLAC-KVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLY 732
+G+G++ VC C T YA+K + K R+ ++ +L + ++ L
Sbjct: 421 IGVGSYS-VCKRCVHKATDTEYAVKIIDKS---KRDPSEEIEI---LLRYGQHPNIITLK 473
Query: 733 YSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDI 792
+ D +Y VM+ + GG+++ ++R F E A + +T ++ +H G +HRD+
Sbjct: 474 DVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDL 533
Query: 793 KPDNILI-DLDG---HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNC 848
KP NIL D G I++ DFG R
Sbjct: 534 KPSNILYRDESGSPESIRVCDFGFAKQLR------------------------------- 562
Query: 849 RCGDRLKTLEQRARKQHQRCLAHSLVGTP----NYIAPEVLLRKGYTQLCDWWSVGVILF 904
+ L+ TP N++APEVL R+GY CD WS+G++L+
Sbjct: 563 --------------------AGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLY 602
Query: 905 EMLVGQPPFL---APTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGR 961
ML G PF TP E ++ + + L +S A+D+++K+ H+ R
Sbjct: 603 TMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQ--R 660
Query: 962 NGADDLKAHPF 972
A + HP+
Sbjct: 661 LTAMQVLKHPW 671
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 209 bits (531), Expect = 1e-53
Identities = 132/357 (36%), Positives = 192/357 (53%), Gaps = 37/357 (10%)
Query: 650 QKESNYNRLKRAKMD--KSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNR 707
Q + + R +AK ++ F IK + GA+G V L DT +AMK + K++++ R
Sbjct: 354 QDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILR 413
Query: 708 NQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHL 767
NQ+ ERDIL A+N +VV ++ SF+ + L VM+Y+ GGD +LL + P +
Sbjct: 414 NQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEM 473
Query: 768 ARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQK 827
AR Y AE LA+E +H G +HRD+KPDN+LI GHIKLTDFGL + + Y+
Sbjct: 474 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYE- 532
Query: 828 GSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLR 887
H+ +D+ E L + GTP YIAPEV+LR
Sbjct: 533 -GHIEKDARE------------------------------FLDKQVCGTPEYIAPEVILR 561
Query: 888 KGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDL 947
+GY + DWW++G+IL+E LVG PF TP E +VI+ ++ L L EA+ L
Sbjct: 562 QGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS-DDILWPEGDEALPTEAQLL 620
Query: 948 ITKLC-CSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFD 1003
I+ L + RLG GA ++K H FF +D++ +R Q A ++P + DTS FD
Sbjct: 621 ISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLR-QKAEFIPHLESEDDTSYFD 676
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 209 bits (531), Expect = 1e-53
Identities = 124/348 (35%), Positives = 180/348 (51%), Gaps = 64/348 (18%)
Query: 668 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW 727
F +IKTLG G+FG V L +T YAMK L K+ V+ Q+ H E+ IL + +
Sbjct: 36 FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 95
Query: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787
+VKL +SF+D +LY VM+Y+PGG+M S L R+ F E ARFY A++ L E +H +
Sbjct: 96 LVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 155
Query: 788 IHRDIKPDNILIDLDGHIKLTDFGLC---TGFRWTHNSKYYQKGSHVRQDSMEPSDLWDD 844
I+RD+KP+N+LID G+I++TDFG G WT
Sbjct: 156 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT------------------------- 190
Query: 845 VSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILF 904
L GTP Y+APE++L KGY + DWW++GV+++
Sbjct: 191 ----------------------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIY 222
Query: 905 EMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADHRLG--R 961
EM G PPF A P + K+++ + P+ S + +DL+ L R G +
Sbjct: 223 EMAAGYPPFFADQPIQIYEKIVS--GKVRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLK 278
Query: 962 NGADDLKAHPFFSAIDFSSDI-RKQPAPYVPTISHPMDTSNFDPVDEE 1008
NG +D+K H +F+ D+ + RK AP++P P DTSNFD +EE
Sbjct: 279 NGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEE 326
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 208 bits (530), Expect = 2e-53
Identities = 123/348 (35%), Positives = 182/348 (52%), Gaps = 64/348 (18%)
Query: 668 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW 727
F +++TLG+G+FG V L +T YAMK L K+ V+ QV H+ E+ IL D +
Sbjct: 44 FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPF 103
Query: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787
+VKL +SF+D LY VM+Y+PGG+M S L R+ F E A FY A++ LA++ +H +
Sbjct: 104 LVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDL 163
Query: 788 IHRDIKPDNILIDLDGHIKLTDFGLC---TGFRWTHNSKYYQKGSHVRQDSMEPSDLWDD 844
IHRD+KP+N+LID G++++TDFG G WT
Sbjct: 164 IHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWT------------------------- 198
Query: 845 VSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILF 904
L GTP Y+APE++L KGY + DWW++GV+++
Sbjct: 199 ----------------------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIY 230
Query: 905 EMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADHRLG--R 961
EM VG PPF A P + K+++ + P+ KLS + + L+ L R G R
Sbjct: 231 EMAVGFPPFYADQPIQIYEKIVS--GRVRFPS--KLSSDLKHLLRSLLQVDLTKRFGNLR 286
Query: 962 NGADDLKAHPFFSAIDFSSDIRKQ-PAPYVPTISHPMDTSNFDPVDEE 1008
NG D+K H +F+ + + K+ AP++P + P D SNFD +EE
Sbjct: 287 NGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEE 334
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
a [Homo sapiens]
Length = 735
Score = 206 bits (525), Expect = 7e-53
Identities = 153/464 (32%), Positives = 236/464 (50%), Gaps = 81/464 (17%)
Query: 633 KAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKV---D 689
+AGL ++ E + K + +++ + K D S F +K LG G+FG+V L KV D
Sbjct: 29 EAGLQPSKDEGVLKEI--SITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPD 86
Query: 690 THALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIP 749
+ LYAMK L+K + R++V K ERDILA+ ++ +VVKL+Y+FQ + LY ++D++
Sbjct: 87 SGHLYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLR 145
Query: 750 GGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTD 809
GGD+ + L + +F E +FY+AEL L ++ +H +G I+RD+KP+NIL+D +GHIKLTD
Sbjct: 146 GGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTD 205
Query: 810 FGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCL 869
FGL S E D H++
Sbjct: 206 FGL----------------------SKEAID------------------------HEK-K 218
Query: 870 AHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWE 929
A+S GT Y+APEV+ R+G++ DWWS GV++FEML G PF ET ++ +
Sbjct: 219 AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL--K 276
Query: 930 NTLHIPAQVKLSPEARDLITKLC-CSADHRLGR--NGADDLKAHPFFSAIDFSSDIRKQ- 985
L +P LS EA+ L+ L + +RLG +GA+++K H F+S ID++ R++
Sbjct: 277 AKLGMPQ--FLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREI 334
Query: 986 PAPYVPTISHPMDTSNFDP-----VDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEF 1040
P+ P ++ P DT FD ++SP S G+ H + F
Sbjct: 335 KPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGA-------------HQLFRGFSF 381
Query: 1041 TFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSD--LVDQTEG 1082
+D+G P P + Q +L SD +V +T G
Sbjct: 382 VATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIG 425
Score = 97.4 bits (241), Expect = 6e-20
Identities = 79/321 (24%), Positives = 140/321 (43%), Gaps = 70/321 (21%)
Query: 668 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW 727
+V +T+G+G++ E T+ YA+K + K R+ ++ +L +
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS---KRDPSEEIEI---LLRYGQHPN 471
Query: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787
++ L + D +Y V + + GG+++ ++R + F E A F + + +E +H G
Sbjct: 472 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 531
Query: 788 IHRDIKPDNIL-IDLDGH---IKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWD 843
+HRD+KP NIL +D G+ +++ DFG R
Sbjct: 532 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLR-------------------------- 565
Query: 844 DVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTP----NYIAPEVLLRKGYTQLCDWWSV 899
+ L+ TP N++APEVL R+GY + CD WS+
Sbjct: 566 -------------------------AENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 600
Query: 900 GVILFEMLVGQPPFL---APTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSAD 956
G++L+ ML G PF + TP E ++ + + TL +S A+DL++K+
Sbjct: 601 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660
Query: 957 HRLGRNGADDLKAHPFFSAID 977
H+ R A + HP+ + D
Sbjct: 661 HQ--RLTAKQVLQHPWVTQKD 679
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
b [Homo sapiens]
Length = 744
Score = 206 bits (524), Expect = 1e-52
Identities = 148/435 (34%), Positives = 222/435 (51%), Gaps = 79/435 (18%)
Query: 662 KMDKSMFVKIKTLGIGAFGEVCLACKV---DTHALYAMKTLRKKDVLNRNQVAHVKAERD 718
K D S F +K LG G+FG+V L KV D+ LYAMK L+K + R++V K ERD
Sbjct: 65 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERD 123
Query: 719 ILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLA 778
ILA+ ++ +VVKL+Y+FQ + LY ++D++ GGD+ + L + +F E +FY+AEL L
Sbjct: 124 ILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 183
Query: 779 IESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEP 838
++ +H +G I+RD+KP+NIL+D +GHIKLTDFGL S E
Sbjct: 184 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGL----------------------SKEA 221
Query: 839 SDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWS 898
D H++ A+S GT Y+APEV+ R+G++ DWWS
Sbjct: 222 ID------------------------HEK-KAYSFCGTVEYMAPEVVNRQGHSHSADWWS 256
Query: 899 VGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADH 957
GV++FEML G PF ET ++ + L +P LS EA+ L+ L + +
Sbjct: 257 YGVLMFEMLTGSLPFQGKDRKETMTLIL--KAKLGMPQ--FLSTEAQSLLRALFKRNPAN 312
Query: 958 RLGR--NGADDLKAHPFFSAIDFSSDIRKQ-PAPYVPTISHPMDTSNFDP-----VDEES 1009
RLG +GA+++K H F+S ID++ R++ P+ P ++ P DT FD ++S
Sbjct: 313 RLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDS 372
Query: 1010 PWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESS 1069
P S G+ H + F +D+G P P + Q
Sbjct: 373 PGIPPSAGA-------------HQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGK 419
Query: 1070 DLESSD--LVDQTEG 1082
+L SD +V +T G
Sbjct: 420 NLVFSDGYVVKETIG 434
Score = 97.4 bits (241), Expect = 6e-20
Identities = 79/321 (24%), Positives = 140/321 (43%), Gaps = 70/321 (21%)
Query: 668 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW 727
+V +T+G+G++ E T+ YA+K + K R+ ++ +L +
Sbjct: 427 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS---KRDPSEEIEI---LLRYGQHPN 480
Query: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787
++ L + D +Y V + + GG+++ ++R + F E A F + + +E +H G
Sbjct: 481 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 540
Query: 788 IHRDIKPDNIL-IDLDGH---IKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWD 843
+HRD+KP NIL +D G+ +++ DFG R
Sbjct: 541 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLR-------------------------- 574
Query: 844 DVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTP----NYIAPEVLLRKGYTQLCDWWSV 899
+ L+ TP N++APEVL R+GY + CD WS+
Sbjct: 575 -------------------------AENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 609
Query: 900 GVILFEMLVGQPPFL---APTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSAD 956
G++L+ ML G PF + TP E ++ + + TL +S A+DL++K+
Sbjct: 610 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 669
Query: 957 HRLGRNGADDLKAHPFFSAID 977
H+ R A + HP+ + D
Sbjct: 670 HQ--RLTAKQVLQHPWVTQKD 688
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 203 bits (516), Expect = 8e-52
Identities = 129/388 (33%), Positives = 194/388 (50%), Gaps = 72/388 (18%)
Query: 628 EQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACK 687
E E K L +A+++ ++K ++N A ++ F + KTLG G+FG V L
Sbjct: 12 EVESVKEFLAKAKEDFLKKWENPTQNN------AGLED--FERKKTLGTGSFGRVMLVKH 63
Query: 688 VDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDY 747
T YAMK L K+ V+ Q+ H E+ IL + ++V+L Y+F+D +LY VM+Y
Sbjct: 64 KATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEY 123
Query: 748 IPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKL 807
+PGG+M S L R+ F E ARFY A++ L E +H + I+RD+KP+N+LID G+I++
Sbjct: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQV 183
Query: 808 TDFGLC---TGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQ 864
TDFG G WT
Sbjct: 184 TDFGFAKRVKGRTWT--------------------------------------------- 198
Query: 865 HQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLK 924
L GTP Y+APE++L KGY + DWW++GV+++EM G PPF A P + K
Sbjct: 199 --------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250
Query: 925 VINWENTLHIPAQVKLSPEARDLITKLC-CSADHRLG--RNGADDLKAHPFFSAIDFSSD 981
+++ + P+ S + +DL+ L R G +NG D+K H +F+ D+ +
Sbjct: 251 IVS--GKVRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAI 306
Query: 982 I-RKQPAPYVPTISHPMDTSNFDPVDEE 1008
RK AP++P DTSNFD +EE
Sbjct: 307 YQRKVEAPFIPKFRGSGDTSNFDDYEEE 334
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 202 bits (514), Expect = 1e-51
Identities = 121/348 (34%), Positives = 176/348 (50%), Gaps = 64/348 (18%)
Query: 668 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW 727
F + KTLG G+FG V L T YAMK L K+ V+ Q+ H E+ IL + +
Sbjct: 91 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 150
Query: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787
+V+L Y+F+D +LY VM+Y+PGG+M S L R+ F E ARFY A++ L E +H +
Sbjct: 151 LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 210
Query: 788 IHRDIKPDNILIDLDGHIKLTDFGLC---TGFRWTHNSKYYQKGSHVRQDSMEPSDLWDD 844
I+RD+KP+N+LID G+I++TDFG G WT
Sbjct: 211 IYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWT------------------------- 245
Query: 845 VSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILF 904
L GTP Y+APE++L KGY + DWW++GV+++
Sbjct: 246 ----------------------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIY 277
Query: 905 EMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADHRLG--R 961
EM G PPF A P + K+++ + P+ S + +DL+ L R G +
Sbjct: 278 EMAAGYPPFFADQPIQIYEKIVS--GKVRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLK 333
Query: 962 NGADDLKAHPFFSAIDFSSDI-RKQPAPYVPTISHPMDTSNFDPVDEE 1008
NG D+K H +F+ D+ + RK AP++P DTSNFD +EE
Sbjct: 334 NGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEE 381
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 202 bits (513), Expect = 2e-51
Identities = 128/348 (36%), Positives = 188/348 (54%), Gaps = 57/348 (16%)
Query: 662 KMDKSMFVKIKTLGIGAFGEVCLACKV---DTHALYAMKTLRKKDVLNRNQVAHVKAERD 718
K D + F +K LG G+FG+V L K D LYAMK L+K + R++V K ERD
Sbjct: 67 KADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERD 125
Query: 719 ILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLA 778
IL E ++ ++VKL+Y+FQ + LY ++D++ GGD+ + L + +F E +FY+AEL LA
Sbjct: 126 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 185
Query: 779 IESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEP 838
++ +H++G ++RD+KP+NIL+D GHIKLTDFGL S E
Sbjct: 186 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGL----------------------SKES 223
Query: 839 SDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWS 898
D Q A+S GT Y+APEV+ R+G++Q DWWS
Sbjct: 224 VD-------------------------QEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWS 258
Query: 899 VGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADH 957
GV++FEML G PF ET ++ + L +P LS EA+ L+ L + +
Sbjct: 259 YGVLMFEMLTGTLPFQGKDRNETMNMIL--KAKLGMPQ--FLSAEAQSLLRMLFKRNPAN 314
Query: 958 RLGRNGADDLKAHPFFSAIDFSSDIRKQ-PAPYVPTISHPMDTSNFDP 1004
RLG G +++K H FF+ ID+ +++ P+ P P DT FDP
Sbjct: 315 RLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDP 362
Score = 84.3 bits (207), Expect = 6e-16
Identities = 73/308 (23%), Positives = 134/308 (43%), Gaps = 56/308 (18%)
Query: 674 LGIGAFGEVCLAC-KVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLY 732
+G+G++ VC C T+ +A+K + K R+ ++ ++ + ++ L
Sbjct: 432 IGVGSYS-VCKRCIHATTNMEFAVKIIDKS---KRDPSEEIEI---LMRYGQHPNIITLK 484
Query: 733 YSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDI 792
F D +Y V D + GG+++ +++ + F E A + ++ ++ +H G +HRD+
Sbjct: 485 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 544
Query: 793 KPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGD 852
KP NIL M+ S D + C G
Sbjct: 545 KPSNILY------------------------------------MDESASADSIRICDFG- 567
Query: 853 RLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPP 912
++ R ++ L T N++APEVL+++GY CD WS+GV+ + ML G P
Sbjct: 568 ----FAKQLRGENGLLLTPCY--TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTP 621
Query: 913 FL---APTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKA 969
F TP E L++ N + +L +S A+DL++ + H+ R A+ +
Sbjct: 622 FANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQ--RYTAEQILK 679
Query: 970 HPFFSAID 977
H + + D
Sbjct: 680 HSWITHRD 687
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,515,229
Number of Sequences: 37866
Number of extensions: 3120288
Number of successful extensions: 24135
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 757
Number of HSP's successfully gapped in prelim test: 890
Number of HSP's that attempted gapping in prelim test: 15703
Number of HSP's gapped (non-prelim): 6450
length of query: 1088
length of database: 18,247,518
effective HSP length: 113
effective length of query: 975
effective length of database: 13,968,660
effective search space: 13619443500
effective search space used: 13619443500
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.