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Search of human proteins with 126091130
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126091130 Gab3 protein isoform 1 [Homo sapiens]
(587 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126091130 Gab3 protein isoform 1 [Homo sapiens] 1195 0.0
gi|18079323 Gab3 protein isoform 2 [Homo sapiens] 1189 0.0
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 298 9e-81
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 244 2e-64
gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sap... 234 2e-61
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 229 7e-60
gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 134 2e-31
gi|221219024 pleckstrin homology-like domain, family B, member 1... 51 3e-06
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 51 3e-06
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 51 3e-06
gi|221219026 pleckstrin homology-like domain, family B, member 1... 50 4e-06
gi|197313732 pleckstrin homology-like domain, family B, member 2... 49 1e-05
gi|197313730 pleckstrin homology-like domain, family B, member 2... 49 1e-05
gi|197313728 pleckstrin homology-like domain, family B, member 2... 49 1e-05
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 49 1e-05
gi|50234893 pleckstrin homology domain containing, family A (pho... 49 1e-05
gi|31377720 pleckstrin homology domain containing, family A (pho... 49 1e-05
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 49 2e-05
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 49 2e-05
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 49 2e-05
gi|46391075 hypothetical protein LOC79949 [Homo sapiens] 47 6e-05
gi|157266264 pleckstrin homology-like domain, family B, member 3... 46 8e-05
gi|5031805 insulin receptor substrate 1 [Homo sapiens] 45 1e-04
gi|154354979 myosin X [Homo sapiens] 45 2e-04
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 44 4e-04
gi|156616273 pleckstrin [Homo sapiens] 43 0.001
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 42 0.002
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 41 0.004
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 41 0.004
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 41 0.004
>gi|126091130 Gab3 protein isoform 1 [Homo sapiens]
Length = 587
Score = 1195 bits (3091), Expect = 0.0
Identities = 587/587 (100%), Positives = 587/587 (100%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI
Sbjct: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH
Sbjct: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
Query: 121 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 180
LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF
Sbjct: 121 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 180
Query: 181 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 240
LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC
Sbjct: 181 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 240
Query: 241 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 300
HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE
Sbjct: 241 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 300
Query: 301 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 360
LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE
Sbjct: 301 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 360
Query: 361 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 420
GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS
Sbjct: 361 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 420
Query: 421 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 480
GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS
Sbjct: 421 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 480
Query: 481 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 540
FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN
Sbjct: 481 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 540
Query: 541 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 587
SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV
Sbjct: 541 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 587
>gi|18079323 Gab3 protein isoform 2 [Homo sapiens]
Length = 586
Score = 1189 bits (3075), Expect = 0.0
Identities = 586/587 (99%), Positives = 586/587 (99%), Gaps = 1/587 (0%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI
Sbjct: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH
Sbjct: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
Query: 121 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 180
LEDGA DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF
Sbjct: 121 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 179
Query: 181 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 240
LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC
Sbjct: 180 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 239
Query: 241 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 300
HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE
Sbjct: 240 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 299
Query: 301 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 360
LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE
Sbjct: 300 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 359
Query: 361 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 420
GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS
Sbjct: 360 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 419
Query: 421 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 480
GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS
Sbjct: 420 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 479
Query: 481 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 540
FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN
Sbjct: 480 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 539
Query: 541 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 587
SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV
Sbjct: 540 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 586
>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
sapiens]
Length = 676
Score = 298 bits (763), Expect = 9e-81
Identities = 224/675 (33%), Positives = 339/675 (50%), Gaps = 105/675 (15%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
GD VCTGWL KSPPE+KL+RYAW+KRWF+LR GRMSG+PDVLEYY+N HS KP+R+I+L+
Sbjct: 5 GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLN 64
Query: 64 ECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLED 123
C G +F +KE Q++FVF +KT+ RTFYLVA+TE++M WV SI Q+C E+
Sbjct: 65 FCE-QVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123
Query: 124 GAADSMESLS-------YTPSSLQPSS------ASSLLTAHAASSSLPRDDP--NTNAVA 168
+ DS+ ++S +P+ L SS S +H++ +L +P + +
Sbjct: 124 -STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQP 182
Query: 169 TEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQ------------ 216
T T + E L+L + E R S TR SD ++++
Sbjct: 183 TLSTSAPQEYLYL-HQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGI 241
Query: 217 -------------ASFDDVFVDCLQPLPSSHLVHPSCHGS------GAQEVPSSRPQAAL 257
+ + F D LP S H GS ++V + + +
Sbjct: 242 SGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNT 301
Query: 258 IWSREINGPPRDHLS--SSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKP 315
+ RE D++ ++PL + T +DKN ++ ++ PPPRPPKP
Sbjct: 302 L-CREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIA--PPPRPPKP 358
Query: 316 SHLSERR---QEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKA-------------DV 359
S R ++ S + + +PRR +L +DN R +A +
Sbjct: 359 SQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGES 418
Query: 360 EGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAG---ASGLGPHCSPDDYI 416
G+S + LP + + + S + ED+YVPM+P + A S YI
Sbjct: 419 AGRSAESMSDGVGSFLPGKMI-VGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYI 477
Query: 417 PMNSG-----SISSPLPELP--------ANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIR 463
PM+ G S+ P LP + ++PPPVNR+LKP RK++P PLDLRN ++I
Sbjct: 478 PMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVID 537
Query: 464 E---HASLTRT-----RTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIEMEEHRT 515
E + +T++ T S + + P S + + S + EE+Y+ M+ +
Sbjct: 538 ELPFKSPITKSWSRANHTFNSSSSQYCRP-----ISTQSITSTDSGDSEENYVPMQNPVS 592
Query: 516 ASSLSSGALTWTKK---FSLDYLALDFNSASPAPMQQKLL--LSEEQRVDYVQVDEQKTQ 570
AS + SG + K S+DYLALDF +SP+P ++ ++ +++VDYVQVD++KTQ
Sbjct: 593 ASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQ 652
Query: 571 ALQSTKQEWTDERQS 585
ALQ+T QEWTD RQS
Sbjct: 653 ALQNTMQEWTDVRQS 667
>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
sapiens]
Length = 694
Score = 244 bits (622), Expect = 2e-64
Identities = 210/699 (30%), Positives = 316/699 (45%), Gaps = 130/699 (18%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DL+ C G +F +KEF+N+++F + T R FYLVA +E+EM WV I +C
Sbjct: 61 DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
Query: 121 LEDGAADSMESLSYTPSS--LQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESEL 178
E+ S P+ L ++A A ++S++LP N ET E
Sbjct: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQE- 178
Query: 179 LFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHP 238
DYL+L NC++ + PTR + S S E D+V P +
Sbjct: 179 -DPQDYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------PSHKNPASSQ 227
Query: 239 SCHGSGA-------QEVPSSRPQAALIWSREINGP------------------------- 266
S HG + P SR +A + S N P
Sbjct: 228 SKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVF 287
Query: 267 -----------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIMSNTPPPRPP 313
H+S S + + +T Q+ + +G+L +K LD + + PPPRPP
Sbjct: 288 NTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTIPDIPPPRPP 346
Query: 314 KPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLR 365
KP +R E T S P + P R + ++ + D Q
Sbjct: 347 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY 406
Query: 366 HRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA----GASGLGPH 409
+ + + +S ++++YVPM+P + +S
Sbjct: 407 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP 466
Query: 410 CSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPPPVNRDLKPQ 446
+Y+PM G+ SSP P P A+ EPPPV+R+LKP
Sbjct: 467 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD 526
Query: 447 RKSRPPPLDLRNLSIIREHASLTR---TRTVPCSRTSF-LSPERNGINSARFFANPVSRE 502
RK +P PL+++ L E + R TR+ + F +SP + ++S ++ S +
Sbjct: 527 RKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTT--SSSDSHD 584
Query: 503 DEESYIEMEEHRT--------ASSLSSGALTWTK---KFSLDYLALDFNSA-SPAPMQQK 550
EE+Y+ M + + ++SL G+ K ++YL LD +S S P +QK
Sbjct: 585 SEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQK 644
Query: 551 LLLS----EEQRVDYVQVDEQKTQALQSTKQEWTDERQS 585
S ++RVDYV VD+QKT AL+ST++ WTD RQS
Sbjct: 645 SSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQS 683
>gi|6912460 GRB2-associated binding protein 2 isoform b [Homo
sapiens]
Length = 638
Score = 234 bits (597), Expect = 2e-61
Identities = 198/641 (30%), Positives = 307/641 (47%), Gaps = 105/641 (16%)
Query: 38 MSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYL 97
MSG+PDVLEYY+N HS KP+R+I+L+ C G +F +KE Q++FVF +KT+ RTFYL
Sbjct: 1 MSGDPDVLEYYKNDHSKKPLRIINLNFCEQ-VDAGLTFNKKELQDSFVFDIKTSERTFYL 59
Query: 98 VAKTEQEMQVWVHSISQVCNLGHLEDGAADSMESLSY-------TPSSLQPSSA------ 144
VA+TE++M WV SI Q+C E+ + DS+ ++S +P+ L SS
Sbjct: 60 VAETEEDMNKWVQSICQICGFNQAEE-STDSLRNVSSAGHGPRSSPAELSSSSQHLLRER 118
Query: 145 SSLLTAHAASSSLPRDDP--NTNAVATEETRSESELLFLPDYLVLSNCETGRLHHTSLPT 202
S +H++ +L +P + + T T + E L+L + E R S T
Sbjct: 119 KSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQ-CISRRAENARSASFSQGT 177
Query: 203 RCDSWSNSDRSLEQAS-------------------------FDDVFVDCLQPLPSSHLVH 237
R SD ++++ + + F D LP S H
Sbjct: 178 RASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASH 237
Query: 238 PSCHGS------GAQEVPSSRPQAALIWSREINGPPRDHLS--SSPLLESSLSSTIQVDK 289
GS ++V + + + + RE D++ ++PL + T +DK
Sbjct: 238 GHTKGSLTGSETDNEDVYTFKTPSNTL-CREFGDLLVDNMDVPATPLSAYQIPRTFTLDK 296
Query: 290 NQGSLPCGAKELDIMSNTPPPRPPKPSHLSERR---QEEWSTHSGSKKPECTLVPRRISL 346
N ++ ++ PPPRPPKPS R ++ S + + +PRR +L
Sbjct: 297 NHNAMTVATPGDSAIA--PPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTL 354
Query: 347 SGLDNMRTWKA-------------DVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDS 393
+DN R +A + G+S + LP + + + S + ED+
Sbjct: 355 PAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMI-VGRSDSTNSEDN 413
Query: 394 YVPMSPQAG---ASGLGPHCSPDDYIPMNSG-----SISSPLPELPAN--------LEPP 437
YVPM+P + A S YIPM+ G S+ P LP + ++PP
Sbjct: 414 YVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPP 473
Query: 438 PVNRDLKPQRKSRPPPLDLRNLSIIRE---HASLTRT-----RTVPCSRTSFLSPERNGI 489
PVNR+LKP RK++P PLDLRN ++I E + +T++ T S + + P
Sbjct: 474 PVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPI---- 529
Query: 490 NSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFS---LDYLALDFNSASPAP 546
S + + S + EE+Y+ M+ +AS + SG + K S +DYLALDF +SP+P
Sbjct: 530 -STQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSP 588
Query: 547 MQQKLLLS--EEQRVDYVQVDEQKTQALQSTKQEWTDERQS 585
++ S +++VDYVQVD++KTQALQ+T QEWTD RQS
Sbjct: 589 HRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQS 629
>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
sapiens]
Length = 724
Score = 229 bits (583), Expect = 7e-60
Identities = 210/729 (28%), Positives = 316/729 (43%), Gaps = 160/729 (21%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
DL+ C G +F +KEF+N+++F + T R FYLVA +E+EM WV I +C
Sbjct: 61 DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
Query: 121 LEDGAADSMESLSYTPSS--LQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESEL 178
E+ S P+ L ++A A ++S++LP N ET E
Sbjct: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQE- 178
Query: 179 LFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHP 238
DYL+L NC++ + PTR + S S E D+V P +
Sbjct: 179 -DPQDYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------PSHKNPASSQ 227
Query: 239 SCHGSGA-------QEVPSSRPQAALIWSREINGP------------------------- 266
S HG + P SR +A + S N P
Sbjct: 228 SKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVF 287
Query: 267 -----------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIMSNTPPPRPP 313
H+S S + + +T Q+ + +G+L +K LD + + PPPRPP
Sbjct: 288 NTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTIPDIPPPRPP 346
Query: 314 KPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLR 365
KP +R E T S P + P R + ++ + D Q
Sbjct: 347 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY 406
Query: 366 HRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA----GASGLGPH 409
+ + + +S ++++YVPM+P + +S
Sbjct: 407 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP 466
Query: 410 CSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPPPVNRDLKPQ 446
+Y+PM G+ SSP P P A+ EPPPV+R+LKP
Sbjct: 467 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD 526
Query: 447 RKS------------------------------RPPPLDLRNLSIIREHASLTR---TRT 473
RK +P PL+++ L E + R TR+
Sbjct: 527 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS 586
Query: 474 VPCSRTSF-LSPERNGINSARFFANPVSREDEESYIEMEEHRT--------ASSLSSGAL 524
+ F +SP + ++S ++ S + EE+Y+ M + + ++SL G+
Sbjct: 587 FARDSSRFPMSPRPDSVHSTT--SSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSS 644
Query: 525 TWTK---KFSLDYLALDFNSA-SPAPMQQKLLLS----EEQRVDYVQVDEQKTQALQSTK 576
K ++YL LD +S S P +QK S ++RVDYV VD+QKT AL+ST+
Sbjct: 645 PMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTR 704
Query: 577 QEWTDERQS 585
+ WTD RQS
Sbjct: 705 EAWTDGRQS 713
>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
sapiens]
Length = 574
Score = 134 bits (338), Expect = 2e-31
Identities = 71/160 (44%), Positives = 101/160 (63%), Gaps = 4/160 (2%)
Query: 3 AGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDL 62
+G + +GWL KSPPE+KL+ +AWRKRWF+LRRG+ S +PDVLEYY+N S KP+R I+L
Sbjct: 37 SGHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINL 96
Query: 63 SEC-AVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHL 121
+ C + V +F +KE Q ++F +KT+ RTFYLVA+T ++M WV SI Q+C
Sbjct: 97 NLCEQLDVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSICQICGFRQE 156
Query: 122 ED-GAADSMESLSY--TPSSLQPSSASSLLTAHAASSSLP 158
E G ++ S S+ S +PS + L +S P
Sbjct: 157 ESTGFLGNISSASHGLCSSPAEPSCSHQHLPQEQEPTSEP 196
Score = 76.3 bits (186), Expect = 8e-14
Identities = 75/221 (33%), Positives = 100/221 (45%), Gaps = 29/221 (13%)
Query: 387 SASIEDSYVPMSP---------QAGASGLGPHCSPDDYIPMNSGSISSPLPELPAN---- 433
S + E S VPM+P QAG G C P + + SPL EL +
Sbjct: 352 SIASEGSCVPMNPGSPTLPAVKQAGDDSQGV-CIPVGSCLVRFDLLGSPLTELSMHQDLS 410
Query: 434 ----LEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS--FLSPERN 487
++ PPVNR LKP +K+ P P +LRN +I E S T P S TS F S
Sbjct: 411 QGHEVQLPPVNRSLKPNQKANPTPPNLRNNRVINE-LSFKPPVTEPWSGTSHTFDSSSSQ 469
Query: 488 GINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFS---LDYLALDFNSASP 544
S + N S + E Y+ +A +S G + S + Y ALDF + P
Sbjct: 470 HPISTQSITNTDSEDSGERYL-FPNPASAFPVSGGTSSSAPPRSTGNIHYAALDFQPSKP 528
Query: 545 APMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQS 585
+ ++ ++VDYVQVD +KTQALQ T E RQS
Sbjct: 529 SIGS----VTSGKKVDYVQVDLEKTQALQKTMHEQMCLRQS 565
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/117 (31%), Positives = 58/117 (49%), Gaps = 20/117 (17%)
Query: 7 VCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--E 64
VC G+LVK + K +W+KRWFV R + + L YY +KH +K VI E
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308
Query: 65 CAVWKHVGPSFVRKEFQNNFV---------FIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ H+ + ++ F+ V F VKT R +Y+VA + + M++W+ I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/117 (31%), Positives = 58/117 (49%), Gaps = 20/117 (17%)
Query: 7 VCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--E 64
VC G+LVK + K +W+KRWFV R + + L YY +KH +K VI E
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308
Query: 65 CAVWKHVGPSFVRKEFQNNFV---------FIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ H+ + ++ F+ V F VKT R +Y+VA + + M++W+ I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/86 (34%), Positives = 45/86 (52%), Gaps = 17/86 (19%)
Query: 26 WRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFV 85
W+ RWF L R L+Y++++ S +PIR++DL+EC S V+ ++ V
Sbjct: 181 WKTRWFTLHRNE-------LKYFKDQMSPEPIRILDLTEC--------SAVQFDYSQERV 225
Query: 86 --FIVKTTSRTFYLVAKTEQEMQVWV 109
F + RTFYL AKT E W+
Sbjct: 226 NCFCLVFPFRTFYLCAKTGVEADEWI 251
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 13/108 (12%)
Query: 7 VCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--E 64
VC G+LVK + K +W+KRWFV R + + L YY +KH +K VI E
Sbjct: 1211 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1261
Query: 65 CAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ H+ + K F VKT R +Y+VA + + M++W+ I
Sbjct: 1262 EVYYDHLRSA--AKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1307
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1139 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1189
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1190 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1139 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1189
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1190 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1123 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1173
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1174 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
+S + C G+L+K + K W+KRWFV R N YY +KH +K VI
Sbjct: 1096 VSITEKTCRGFLIKMGGKIK----TWKKRWFVFDR-----NKRTFSYYADKHETKLKGVI 1146
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSI 112
+ K F VKT R +Y+VA + + M++W+ I
Sbjct: 1147 YFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1198
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/132 (25%), Positives = 69/132 (52%), Gaps = 13/132 (9%)
Query: 26 WRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFV 85
W++R+F L + + + Y++++ +P+RVI L E + S + + +
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDI---MMRDNL 257
Query: 86 FIVKTTSRTFYLVAKTEQEMQVWVHSISQ--VCNLGHLEDGAADSMESLSYTPSSLQPSS 143
F + TTSRTFY+ A + +EM W+ ++S V G +++ S + + +P++
Sbjct: 258 FEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPPGPSESKHAFRPTN 317
Query: 144 ASSLLTAHAASS 155
A++ T+H+ +S
Sbjct: 318 AAT-ATSHSTAS 328
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/132 (25%), Positives = 69/132 (52%), Gaps = 13/132 (9%)
Query: 26 WRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFV 85
W++R+F L + + + Y++++ +P+RVI L E + S + + +
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDI---MMRDNL 257
Query: 86 FIVKTTSRTFYLVAKTEQEMQVWVHSISQ--VCNLGHLEDGAADSMESLSYTPSSLQPSS 143
F + TTSRTFY+ A + +EM W+ ++S V G +++ S + + +P++
Sbjct: 258 FEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPPGPSESKHAFRPTN 317
Query: 144 ASSLLTAHAASS 155
A++ T+H+ +S
Sbjct: 318 AAT-ATSHSTAS 328
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/249 (24%), Positives = 93/249 (37%), Gaps = 36/249 (14%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G A C GWL K + W+K W +L+ L +Y N+ + K ++L
Sbjct: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93
Query: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVW--------VHSISQ 114
+ V + E + F I +TFY A+ QEM VW +H S
Sbjct: 94 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 146
Query: 115 VCNLGHLEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 174
+ + + E + TP S S LTA ASSS P + + ++ E
Sbjct: 147 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 205
Query: 175 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 234
++ F P L SLP +S S ++ + +F V P+PS
Sbjct: 206 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 253
Query: 235 LVHPSCHGS 243
+H + S
Sbjct: 254 GIHKALENS 262
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/249 (24%), Positives = 93/249 (37%), Gaps = 36/249 (14%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G A C GWL K + W+K W +L+ L +Y N+ + K ++L
Sbjct: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93
Query: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVW--------VHSISQ 114
+ V + E + F I +TFY A+ QEM VW +H S
Sbjct: 94 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 146
Query: 115 VCNLGHLEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 174
+ + + E + TP S S LTA ASSS P + + ++ E
Sbjct: 147 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 205
Query: 175 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 234
++ F P L SLP +S S ++ + +F V P+PS
Sbjct: 206 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 253
Query: 235 LVHPSCHGS 243
+H + S
Sbjct: 254 GIHKALENS 262
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/249 (24%), Positives = 93/249 (37%), Gaps = 36/249 (14%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G A C GWL K + W+K W +L+ L +Y N+ + K ++L
Sbjct: 40 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 92
Query: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVW--------VHSISQ 114
+ V + E + F I +TFY A+ QEM VW +H S
Sbjct: 93 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 145
Query: 115 VCNLGHLEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 174
+ + + E + TP S S LTA ASSS P + + ++ E
Sbjct: 146 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 204
Query: 175 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 234
++ F P L SLP +S S ++ + +F V P+PS
Sbjct: 205 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 252
Query: 235 LVHPSCHGS 243
+H + S
Sbjct: 253 GIHKALENS 261
>gi|46391075 hypothetical protein LOC79949 [Homo sapiens]
Length = 363
Score = 46.6 bits (109), Expect = 6e-05
Identities = 42/162 (25%), Positives = 77/162 (47%), Gaps = 20/162 (12%)
Query: 11 WLVKSPPERKLQRY-AWRKRWFVLRR-GRMSGNPDVLEYYRNKHSSKPIRVIDLS--ECA 66
+ +KSPP + +W+KR+F+L + G S + L YY++ H I + S E
Sbjct: 26 YFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFS---LSYYKDHHHRGSIEIDQNSSVEVG 82
Query: 67 VWKHVGPSFVRKEFQ--NNFVFIVKTTSRTFYLVAKTEQEMQVWVHSIS------QVCNL 118
+ V+K F+ + V ++TT+R ++L+ ++++ WV +S +
Sbjct: 83 ISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQ 142
Query: 119 GHLEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRD 160
E+ + + +L Y+ L PSS T+ A SS PR+
Sbjct: 143 NTEEELSLGNKRTLFYSSPLLGPSS-----TSEAVGSSSPRN 179
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 46.2 bits (108), Expect = 8e-05
Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 13/115 (11%)
Query: 8 CTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS--EC 65
C G LVK K WRKRWF R L YY +K +K VI E
Sbjct: 535 CRGPLVKMGGRIK----TWRKRWFCFDRQARR-----LAYYADKEETKLKGVIYFQAIEE 585
Query: 66 AVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
+ H+ +F K F VKT R FY+VA + + M++W+ I + H
Sbjct: 586 VYYDHLRCAF--KSPNPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENH 638
>gi|5031805 insulin receptor substrate 1 [Homo sapiens]
Length = 1242
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/106 (33%), Positives = 48/106 (45%), Gaps = 14/106 (13%)
Query: 28 KRWFVLRRGRMSGNPDVLEYYRNK-----HSSKPIRVIDLSECAVWKHVGPSFVRKEFQN 82
KR+FVLR +G P LEYY N+ SS P R I L C R + +N
Sbjct: 27 KRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINK------RADSKN 80
Query: 83 NFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCN--LGHLEDGAA 126
+ + T F + A +E E W ++ Q+ N GH DGAA
Sbjct: 81 KHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH-HDGAA 125
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/170 (25%), Positives = 69/170 (40%), Gaps = 23/170 (13%)
Query: 2 SAGDAVCTGWL-VKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
S +A+ GWL K L R W+KRWFVLR+ + L Y+ N K +
Sbjct: 1209 SKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSK-------LMYFENDSEEKLKGTV 1261
Query: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
++ + + N + I+ RTF+L+A++ ++ W +SQV H
Sbjct: 1262 EV-------RTAKEIIDNTTKENGIDII-MADRTFHLIAESPEDASQWFSVLSQV----H 1309
Query: 121 LE-DGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVAT 169
D M P + + L+ + AS S D PN+ + T
Sbjct: 1310 ASTDQEIQEMHDEQANPQNAVGTLDVGLIDSVCASDS--PDRPNSFVIIT 1357
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 18/93 (19%)
Query: 25 AWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNF 84
A+ +RWFVLR GN +L Y+ + S +P+ VI L C V E F
Sbjct: 33 AYHRRWFVLR-----GN--MLFYFEDAASREPVGVIILEGCTV--------ELVEAAEEF 77
Query: 85 VFIVK---TTSRTFYLVAKTEQEMQVWVHSISQ 114
F V+ T +RT+ L A+++ M+ WV ++S+
Sbjct: 78 AFAVRFAGTRARTYVLAAESQDAMEGWVKALSR 110
>gi|156616273 pleckstrin [Homo sapiens]
Length = 350
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 9/116 (7%)
Query: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
G + G L+K RK W+ R F+LR +P L YY + P+ I L
Sbjct: 243 GVIIKQGCLLKQGHRRK----NWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLR 293
Query: 64 ECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLG 119
C V S RK + N I+ ++L A T +E W+ +I G
Sbjct: 294 GCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTG 349
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 41.6 bits (96), Expect = 0.002
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 24/120 (20%)
Query: 5 DAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSE 64
+A+ GWL K K W RWFVL+ D L Y++++ +KP+ I L
Sbjct: 19 NAIKCGWLRKQGGFVK----TWHTRWFVLK-------GDQLYYFKDEDETKPLGTIFLPG 67
Query: 65 CAVWKHVGPSFVRKEFQNNFVFIV---------KTTSRTFYLVAKTEQEMQVWVHSISQV 115
V +H +E F+F V ++ L+A T+ +M+ WV SI +V
Sbjct: 68 NKVSEHP----CNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRV 123
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 40.8 bits (94), Expect = 0.004
Identities = 40/138 (28%), Positives = 59/138 (42%), Gaps = 22/138 (15%)
Query: 10 GWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWK 69
GWL K+PP+ Y ++KRW L + D L Y+ + + R I + A
Sbjct: 87 GWLDKNPPQGS---YIYQKRWVRL-------DTDHLRYFDSNKDAYSKRFISV---ACIS 133
Query: 70 HVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADSM 129
HV +K F V T +RTF A+++ E + W+ ++ Q + A S
Sbjct: 134 HVAAIGDQK-------FEVITNNRTFAFRAESDVERKEWMQALQQA--MAEQRARARLSS 184
Query: 130 ESLSYTPSSLQPSSASSL 147
L P S QP A SL
Sbjct: 185 AYLLGVPGSEQPDRAGSL 202
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 40.8 bits (94), Expect = 0.004
Identities = 40/138 (28%), Positives = 59/138 (42%), Gaps = 22/138 (15%)
Query: 10 GWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWK 69
GWL K+PP+ Y ++KRW L + D L Y+ + + R I + A
Sbjct: 87 GWLDKNPPQGS---YIYQKRWVRL-------DTDHLRYFDSNKDAYSKRFISV---ACIS 133
Query: 70 HVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADSM 129
HV +K F V T +RTF A+++ E + W+ ++ Q + A S
Sbjct: 134 HVAAIGDQK-------FEVITNNRTFAFRAESDVERKEWMQALQQA--MAEQRARARLSS 184
Query: 130 ESLSYTPSSLQPSSASSL 147
L P S QP A SL
Sbjct: 185 AYLLGVPGSEQPDRAGSL 202
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 40.8 bits (94), Expect = 0.004
Identities = 40/138 (28%), Positives = 59/138 (42%), Gaps = 22/138 (15%)
Query: 10 GWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWK 69
GWL K+PP+ Y ++KRW L + D L Y+ + + R I + A
Sbjct: 332 GWLDKNPPQGS---YIYQKRWVRL-------DTDHLRYFDSNKDAYSKRFISV---ACIS 378
Query: 70 HVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADSM 129
HV +K F V T +RTF A+++ E + W+ ++ Q + A S
Sbjct: 379 HVAAIGDQK-------FEVITNNRTFAFRAESDVERKEWMQALQQA--MAEQRARARLSS 429
Query: 130 ESLSYTPSSLQPSSASSL 147
L P S QP A SL
Sbjct: 430 AYLLGVPGSEQPDRAGSL 447
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,751,869
Number of Sequences: 37866
Number of extensions: 1418861
Number of successful extensions: 5690
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 5362
Number of HSP's gapped (non-prelim): 428
length of query: 587
length of database: 18,247,518
effective HSP length: 108
effective length of query: 479
effective length of database: 14,157,990
effective search space: 6781677210
effective search space used: 6781677210
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.