Search of human proteins with 41872673

Search of human proteins with 41872673

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41872673 NIMA-related kinase 1 [Homo sapiens]
         (1258 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41872673 NIMA-related kinase 1 [Homo sapiens]                     2500   0.0  
gi|83627721 NIMA-related kinase 5 [Homo sapiens]                      378   e-104
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]           331   2e-90
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]            331   2e-90
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]            331   2e-90
gi|148839316 NIMA-related kinase 4 [Homo sapiens]                     296   1e-79
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                      242   2e-63
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                     232   2e-60
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]           220   6e-57
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]          220   6e-57
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]          220   6e-57
gi|4505373 NIMA-related kinase 2 [Homo sapiens]                       204   6e-52
gi|19424132 NIMA-related kinase 7 [Homo sapiens]                      187   7e-47
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]           185   3e-46
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]            185   3e-46
gi|217330634 serine/threonine kinase 36 [Homo sapiens]                160   5e-39
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   148   4e-35
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   147   8e-35
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   147   8e-35
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   147   8e-35
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   147   8e-35
gi|41872374 polo-like kinase 3 [Homo sapiens]                         145   2e-34
gi|93004081 polo-like kinase 2 [Homo sapiens]                         144   5e-34
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   144   7e-34
gi|121114283 polo-like kinase 4 [Homo sapiens]                        144   7e-34
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   139   2e-32
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                  138   3e-32
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho...   138   3e-32
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   137   5e-32
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   137   5e-32

>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
          Length = 1258

 Score = 2500 bits (6480), Expect = 0.0
 Identities = 1258/1258 (100%), Positives = 1258/1258 (100%)

Query: 1    MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
            MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH
Sbjct: 1    MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60

Query: 61   PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
            PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH
Sbjct: 61   PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120

Query: 121  DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
            DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY
Sbjct: 121  DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180

Query: 181  NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240
            NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK
Sbjct: 181  NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240

Query: 241  RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 300
            RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI
Sbjct: 241  RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI 300

Query: 301  SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 360
            SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE
Sbjct: 301  SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE 360

Query: 361  EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE 420
            EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE
Sbjct: 361  EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE 420

Query: 421  VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL 480
            VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL
Sbjct: 421  VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL 480

Query: 481  PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR 540
            PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR
Sbjct: 481  PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR 540

Query: 541  KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM 600
            KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM
Sbjct: 541  KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM 600

Query: 601  RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE 660
            RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE
Sbjct: 601  RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE 660

Query: 661  TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL 720
            TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL
Sbjct: 661  TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL 720

Query: 721  KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS 780
            KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS
Sbjct: 721  KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS 780

Query: 781  TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG 840
            TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG
Sbjct: 781  TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG 840

Query: 841  EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET 900
            EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET
Sbjct: 841  EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET 900

Query: 901  EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD 960
            EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD
Sbjct: 901  EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD 960

Query: 961  IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH 1020
            IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH
Sbjct: 961  IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH 1020

Query: 1021 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID 1080
            LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID
Sbjct: 1021 LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID 1080

Query: 1081 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP 1140
            EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP
Sbjct: 1081 EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP 1140

Query: 1141 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE 1200
            TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE
Sbjct: 1141 TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE 1200

Query: 1201 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1258
            KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE
Sbjct: 1201 KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1258


>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
          Length = 708

 Score =  378 bits (970), Expect = e-104
 Identities = 184/295 (62%), Positives = 232/295 (78%), Gaps = 4/295 (1%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
           M+KY  ++ IG+G+FGKA L K   D +  VIKEIN  +M  +E+E S++EV +L  MKH
Sbjct: 1   MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           PNIV +  SF+ENG L+IVM+YC+GGDL KRIN Q+GVLF EDQIL WFVQI L LKH+H
Sbjct: 61  PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120

Query: 121 DRKILHRDIKSQNIFLTKDGTV-QLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
           DRKILHRDIK+QNIFL+K+G V +LGDFGIARVLN+++ELARTCIGTPYYLSPEIC+NKP
Sbjct: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180

Query: 180 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLF 239
           YNNK+DIW+LGCVLYELCTLKH FE  +++ LVLKI    F P+S  +S +L SL+SQLF
Sbjct: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240

Query: 240 KRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPA 294
           + +PRDRPS+NSIL++ F+   I K+L+P++I EEF      + G+   PA R A
Sbjct: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGA---PASRHA 292



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 42/298 (14%)

Query: 536 EFLQRKREAMQNKARAEGHMVYLARLRQIRLQ-NFNERQQIKAKLRGEKKEANHSEGQEG 594
           E+LQRK EA Q K + E  +     LR    + N+N+RQ++++   GE+        ++ 
Sbjct: 406 EYLQRKFEAQQYKLKVEKQL----GLRPSSAEPNYNQRQELRS--NGEEPRFQELPFRKN 459

Query: 595 SEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKG-----VKS 649
             +     K++E ++   +     +KE  ++  +E  E  K   + +LV K        +
Sbjct: 460 EMKEQEYWKQLEEIRQQYHND---MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDA 516

Query: 650 SDVSPPLGQHETGGSPSKQQM-RSVISVTSALKEVGVD---SSLTDTRETSEEMQKTNNA 705
           S+   P+        P    M RS ++ TSA +++  D     L +T+E+    QK    
Sbjct: 517 SEGEAPVQMEFRSCCPGWSAMARSWLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAK 576

Query: 706 ISSKREI-LRRL--NENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEA 762
              K EI L +   +EN+  +E+     N + TFE  +     E  KE    +D+    A
Sbjct: 577 KGVKFEINLDKCISDENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDK----A 632

Query: 763 GGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAEL 820
             +L  P      +  FST     VG           RR W      ++L+++  A++
Sbjct: 633 FEKLHCP------EAGFSTQTVAAVGN----------RRQWDGGAPQTLLQMMAVADI 674


>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
          Length = 489

 Score =  331 bits (849), Expect = 2e-90
 Identities = 151/273 (55%), Positives = 206/273 (75%), Gaps = 1/273 (0%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
           M+ Y+ L+ IGEGSFG+A+LV+     + + +KEI + + S    + SR+E  +LA MKH
Sbjct: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           PNIV ++ESFE  G LYIVM+YC+GGDL ++I  QKG LF ED IL+WF Q+CL + H+H
Sbjct: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119

Query: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
            +++LHRDIKS+NIFLT++G V+LGDFG AR+L++ +  A T +GTPYY+ PEI EN PY
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179

Query: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240
           NNKSDIW+LGC+LYELCTLKH F+A S KNL+LK+  G   P+  HYSY+L+ LV Q+FK
Sbjct: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239

Query: 241 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 273
           RNP  RPS  ++L +G +A+ ++K L P++I E
Sbjct: 240 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272


>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score =  331 bits (849), Expect = 2e-90
 Identities = 151/273 (55%), Positives = 206/273 (75%), Gaps = 1/273 (0%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
           M+ Y+ L+ IGEGSFG+A+LV+     + + +KEI + + S    + SR+E  +LA MKH
Sbjct: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           PNIV ++ESFE  G LYIVM+YC+GGDL ++I  QKG LF ED IL+WF Q+CL + H+H
Sbjct: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119

Query: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
            +++LHRDIKS+NIFLT++G V+LGDFG AR+L++ +  A T +GTPYY+ PEI EN PY
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179

Query: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240
           NNKSDIW+LGC+LYELCTLKH F+A S KNL+LK+  G   P+  HYSY+L+ LV Q+FK
Sbjct: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239

Query: 241 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 273
           RNP  RPS  ++L +G +A+ ++K L P++I E
Sbjct: 240 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272


>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score =  331 bits (849), Expect = 2e-90
 Identities = 151/273 (55%), Positives = 206/273 (75%), Gaps = 1/273 (0%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
           M+ Y+ L+ IGEGSFG+A+LV+     + + +KEI + + S    + SR+E  +LA MKH
Sbjct: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           PNIV ++ESFE  G LYIVM+YC+GGDL ++I  QKG LF ED IL+WF Q+CL + H+H
Sbjct: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119

Query: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
            +++LHRDIKS+NIFLT++G V+LGDFG AR+L++ +  A T +GTPYY+ PEI EN PY
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179

Query: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240
           NNKSDIW+LGC+LYELCTLKH F+A S KNL+LK+  G   P+  HYSY+L+ LV Q+FK
Sbjct: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239

Query: 241 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 273
           RNP  RPS  ++L +G +A+ ++K L P++I E
Sbjct: 240 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272


>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
          Length = 841

 Score =  296 bits (757), Expect = 1e-79
 Identities = 135/264 (51%), Positives = 195/264 (73%), Gaps = 1/264 (0%)

Query: 4   YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           Y  L+ +G+GS+G+  LVK   DG+QYVIK++N+   SS+ER  + +E  +L+ +KHPNI
Sbjct: 6   YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65

Query: 64  VQYRESFEE-NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 122
           V Y+ES+E  +G LYIVM +CEGGDL++++  QKG L  E+Q+++WFVQI +AL+++H++
Sbjct: 66  VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125

Query: 123 KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNN 182
            ILHRD+K+QN+FLT+   +++GD GIARVL +  ++A T IGTPYY+SPE+  NKPYN 
Sbjct: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185

Query: 183 KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRN 242
           KSD+WALGC +YE+ TLKHAF A  M +LV +II G  PP+   YS +L  L+  +  + 
Sbjct: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245

Query: 243 PRDRPSVNSILEKGFIAKRIEKFL 266
           P +RPSV SIL + +I ++I  FL
Sbjct: 246 PEERPSVRSILRQPYIKRQISFFL 269


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score =  242 bits (617), Expect = 2e-63
 Identities = 124/254 (48%), Positives = 173/254 (68%), Gaps = 2/254 (0%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
           MEKY R++ +G G+FG   L     D +  +IK+I + +M+ +ER+ ++ E  VL  + H
Sbjct: 1   MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           PN+++Y E+F E+ +L I M+Y  GG L + I  +   L +E+ IL +FVQI LAL HVH
Sbjct: 61  PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120

Query: 121 DRKILHRDIKSQNIFLTKDG-TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
              ILHRD+K+QNI L K    V++GDFGI+++L+S  + A T +GTP Y+SPE+CE KP
Sbjct: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKP 179

Query: 180 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLF 239
           YN KSDIWALGCVLYEL +LK AFEA ++  LVLKI+SG+F P+S  YS +LR LV  L 
Sbjct: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239

Query: 240 KRNPRDRPSVNSIL 253
              P  RP ++ I+
Sbjct: 240 SLEPAQRPPLSHIM 253


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score =  232 bits (591), Expect = 2e-60
 Identities = 110/260 (42%), Positives = 172/260 (66%), Gaps = 2/260 (0%)

Query: 4   YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           Y+ ++ +G G+FG+A L + TED    V KE++++R+S KER ++  E+ +LA ++H NI
Sbjct: 52  YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           + Y   F +N +L I ++YC GG+L+ +I  QK  LF+E+ ++ +  QI  A+  +H   
Sbjct: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171

Query: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
           ILHRDIK+ NIFLTK   ++LGD+G+A+ LNS   +A T +GTPYY+SPE+C+   YN K
Sbjct: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFK 231

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG--SFPPVSLHYSYDLRSLVSQLFKR 241
           SDIWA+GCV++EL TLK  F+A +  NL +KI+ G  +    S  YS +L  +V     +
Sbjct: 232 SDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQ 291

Query: 242 NPRDRPSVNSILEKGFIAKR 261
           +P  RP+ + +L++  + KR
Sbjct: 292 DPEQRPTADELLDRPLLRKR 311


>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
          Length = 470

 Score =  220 bits (561), Expect = 6e-57
 Identities = 104/269 (38%), Positives = 176/269 (65%), Gaps = 6/269 (2%)

Query: 3   KYVRLQKIGEGSFGKAILV--KSTEDGRQY-VIKEINISRMSSKEREESRREVAVLANMK 59
           +YV  QK+G GSFG   LV  K  + G +  V+KEI++  ++  E  ++  E  +L+ + 
Sbjct: 28  RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87

Query: 60  HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQK--GVLFQEDQILDWFVQICLALK 117
           HP IV++  SF E  +  I+ +YCEG DL  +I   K  G +F E+QI++WF+Q+ L + 
Sbjct: 88  HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147

Query: 118 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 177
           ++H+R+ILHRD+KS+N+FL K+  +++GDFG++R+L  + +LA T  GTP+Y+SPE  ++
Sbjct: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206

Query: 178 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 237
           + Y+ KSDIW+L C+LYE+C + HAF   +  ++VLKI+ G  P +   Y  +L +++  
Sbjct: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266

Query: 238 LFKRNPRDRPSVNSILEKGFIAKRIEKFL 266
           +  +NP  RPS   IL+  ++ ++++  +
Sbjct: 267 MLNKNPSLRPSAIEILKIPYLDEQLQNLM 295


>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
          Length = 599

 Score =  220 bits (561), Expect = 6e-57
 Identities = 104/269 (38%), Positives = 176/269 (65%), Gaps = 6/269 (2%)

Query: 3   KYVRLQKIGEGSFGKAILV--KSTEDGRQY-VIKEINISRMSSKEREESRREVAVLANMK 59
           +YV  QK+G GSFG   LV  K  + G +  V+KEI++  ++  E  ++  E  +L+ + 
Sbjct: 28  RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87

Query: 60  HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQK--GVLFQEDQILDWFVQICLALK 117
           HP IV++  SF E  +  I+ +YCEG DL  +I   K  G +F E+QI++WF+Q+ L + 
Sbjct: 88  HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147

Query: 118 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 177
           ++H+R+ILHRD+KS+N+FL K+  +++GDFG++R+L  + +LA T  GTP+Y+SPE  ++
Sbjct: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206

Query: 178 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 237
           + Y+ KSDIW+L C+LYE+C + HAF   +  ++VLKI+ G  P +   Y  +L +++  
Sbjct: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266

Query: 238 LFKRNPRDRPSVNSILEKGFIAKRIEKFL 266
           +  +NP  RPS   IL+  ++ ++++  +
Sbjct: 267 MLNKNPSLRPSAIEILKIPYLDEQLQNLM 295


>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
          Length = 645

 Score =  220 bits (561), Expect = 6e-57
 Identities = 104/269 (38%), Positives = 176/269 (65%), Gaps = 6/269 (2%)

Query: 3   KYVRLQKIGEGSFGKAILV--KSTEDGRQY-VIKEINISRMSSKEREESRREVAVLANMK 59
           +YV  QK+G GSFG   LV  K  + G +  V+KEI++  ++  E  ++  E  +L+ + 
Sbjct: 28  RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87

Query: 60  HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQK--GVLFQEDQILDWFVQICLALK 117
           HP IV++  SF E  +  I+ +YCEG DL  +I   K  G +F E+QI++WF+Q+ L + 
Sbjct: 88  HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147

Query: 118 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 177
           ++H+R+ILHRD+KS+N+FL K+  +++GDFG++R+L  + +LA T  GTP+Y+SPE  ++
Sbjct: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206

Query: 178 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 237
           + Y+ KSDIW+L C+LYE+C + HAF   +  ++VLKI+ G  P +   Y  +L +++  
Sbjct: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266

Query: 238 LFKRNPRDRPSVNSILEKGFIAKRIEKFL 266
           +  +NP  RPS   IL+  ++ ++++  +
Sbjct: 267 MLNKNPSLRPSAIEILKIPYLDEQLQNLM 295


>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
          Length = 445

 Score =  204 bits (518), Expect = 6e-52
 Identities = 113/267 (42%), Positives = 153/267 (57%), Gaps = 9/267 (3%)

Query: 2   EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 61
           E Y  L  IG GS+G+   ++   DG+  V KE++   M+  E++    EV +L  +KHP
Sbjct: 6   EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65

Query: 62  NIVQYRESFEE--NGSLYIVMDYCEGGDLFKRIN--AQKGVLFQEDQILDWFVQICLALK 117
           NIV+Y +   +  N +LYIVM+YCEGGDL   I    ++     E+ +L    Q+ LALK
Sbjct: 66  NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125

Query: 118 HVHDRK-----ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSP 172
             H R      +LHRD+K  N+FL     V+LGDFG+AR+LN     A+T +GTPYY+SP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185

Query: 173 EICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLR 232
           E      YN KSDIW+LGC+LYELC L   F A S K L  KI  G F  +   YS +L 
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245

Query: 233 SLVSQLFKRNPRDRPSVNSILEKGFIA 259
            +++++       RPSV  ILE   IA
Sbjct: 246 EIITRMLNLKDYHRPSVEEILENPLIA 272


>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
          Length = 302

 Score =  187 bits (474), Expect = 7e-47
 Identities = 101/261 (38%), Positives = 150/261 (57%), Gaps = 9/261 (3%)

Query: 8   QKIGEGSFGKAILVKSTEDGRQYVIKEINI-SRMSSKEREESRREVAVLANMKHPNIVQY 66
           +KIG G F +        DG    +K++ I   M +K R +  +E+ +L  + HPN+++Y
Sbjct: 38  KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97

Query: 67  RESFEENGSLYIVMDYCEGGDLFKRINAQKGV--LFQEDQILDWFVQICLALKHVHDRKI 124
             SF E+  L IV++  + GDL + I   K    L  E  +  +FVQ+C AL+H+H R++
Sbjct: 98  YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157

Query: 125 LHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKS 184
           +HRDIK  N+F+T  G V+LGD G+ R  +S    A + +GTPYY+SPE      YN KS
Sbjct: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKS 217

Query: 185 DIWALGCVLYELCTLKHAFEAGSMK--NLVLKIISGSFPPV-SLHYSYDLRSLVSQLFKR 241
           DIW+LGC+LYE+  L+  F    M   +L  KI    +PP+ S HYS +LR LV+     
Sbjct: 218 DIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINP 277

Query: 242 NPRDRPSVNSILEKGFIAKRI 262
           +P  RP V  + +   +AKR+
Sbjct: 278 DPEKRPDVTYVYD---VAKRM 295


>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
          Length = 347

 Score =  185 bits (469), Expect = 3e-46
 Identities = 99/266 (37%), Positives = 153/266 (57%), Gaps = 9/266 (3%)

Query: 8   QKIGEGSFGKAILVKSTEDGRQYVIKEINI-SRMSSKEREESRREVAVLANMKHPNIVQY 66
           +KIG G F +        D +   +K++ I   M +K R++  +E+ +L  + HPNI++Y
Sbjct: 83  KKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKY 142

Query: 67  RESFEENGSLYIVMDYCEGGDLFKRINAQKGV--LFQEDQILDWFVQICLALKHVHDRKI 124
            +SF E+  L IV++  + GDL + I   K    L  E  +  +FVQ+C A++H+H R++
Sbjct: 143 LDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 202

Query: 125 LHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKS 184
           +HRDIK  N+F+T  G V+LGD G+ R  +S    A + +GTPYY+SPE      YN KS
Sbjct: 203 MHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKS 262

Query: 185 DIWALGCVLYELCTLKHAFEAGSMK--NLVLKIISGSFPPV-SLHYSYDLRSLVSQLFKR 241
           DIW+LGC+LYE+  L+  F    M   +L  KI    +PP+   HYS  LR LVS     
Sbjct: 263 DIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICP 322

Query: 242 NPRDRPSVNSILEKGFIAKRIEKFLS 267
           +P  RP +  + +   +AK++  ++S
Sbjct: 323 DPHQRPDIGYVHQ---VAKQMHIWMS 345


>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
          Length = 313

 Score =  185 bits (469), Expect = 3e-46
 Identities = 99/266 (37%), Positives = 153/266 (57%), Gaps = 9/266 (3%)

Query: 8   QKIGEGSFGKAILVKSTEDGRQYVIKEINI-SRMSSKEREESRREVAVLANMKHPNIVQY 66
           +KIG G F +        D +   +K++ I   M +K R++  +E+ +L  + HPNI++Y
Sbjct: 49  KKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKY 108

Query: 67  RESFEENGSLYIVMDYCEGGDLFKRINAQKGV--LFQEDQILDWFVQICLALKHVHDRKI 124
            +SF E+  L IV++  + GDL + I   K    L  E  +  +FVQ+C A++H+H R++
Sbjct: 109 LDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 168

Query: 125 LHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKS 184
           +HRDIK  N+F+T  G V+LGD G+ R  +S    A + +GTPYY+SPE      YN KS
Sbjct: 169 MHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKS 228

Query: 185 DIWALGCVLYELCTLKHAFEAGSMK--NLVLKIISGSFPPV-SLHYSYDLRSLVSQLFKR 241
           DIW+LGC+LYE+  L+  F    M   +L  KI    +PP+   HYS  LR LVS     
Sbjct: 229 DIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICP 288

Query: 242 NPRDRPSVNSILEKGFIAKRIEKFLS 267
           +P  RP +  + +   +AK++  ++S
Sbjct: 289 DPHQRPDIGYVHQ---VAKQMHIWMS 311


>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
          Length = 1315

 Score =  160 bits (406), Expect = 5e-39
 Identities = 98/268 (36%), Positives = 147/268 (54%), Gaps = 4/268 (1%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
           MEKY  L+ IGEGSFG+    +     +   +K I     S KE    +RE+ ++  ++H
Sbjct: 1   MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH 60

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           PNIV   +SFE +  + +V DY EG +LF+ I    G L  EDQ+     Q+  AL ++H
Sbjct: 61  PNIVHMLDSFETDKEVVVVTDYAEG-ELFQ-ILEDDGKL-PEDQVQAIAAQLVSALYYLH 117

Query: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
             +ILHRD+K QNI L K G ++L DFG AR +++   +  +  GTP Y+SPE+ E +PY
Sbjct: 118 SHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPY 177

Query: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240
           ++ +D+W++GC+LYEL      F A S+  LV  I+       S   S   ++ +  L  
Sbjct: 178 DHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPST-ISPCFKNFLQGLLT 236

Query: 241 RNPRDRPSVNSILEKGFIAKRIEKFLSP 268
           ++PR R S   +L   FIA  +     P
Sbjct: 237 KDPRQRLSWPDLLYHPFIAGHVTIITEP 264


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  148 bits (373), Expect = 4e-35
 Identities = 79/243 (32%), Positives = 140/243 (57%), Gaps = 6/243 (2%)

Query: 7   LQKIGEGSFGKAILVK--STEDGRQ-YVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           L+ +G+GSFGK  LVK  S  D RQ Y +K +  + +  ++R  ++ E  +L  + HP I
Sbjct: 71  LKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFI 130

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           V+   +F+  G LY+++D+  GGDLF R++  K V+F E+ +  +  ++ LAL H+H   
Sbjct: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLG 188

Query: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
           I++RD+K +NI L ++G ++L DFG+++      + A +  GT  Y++PE+   + +   
Sbjct: 189 IIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQS 248

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNP 243
           +D W+ G +++E+ T    F+    K  +  I+      +    S + +SL+  LFKRNP
Sbjct: 249 ADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKL-GMPQFLSPEAQSLLRMLFKRNP 307

Query: 244 RDR 246
            +R
Sbjct: 308 ANR 310



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 77/325 (23%), Positives = 149/325 (45%), Gaps = 31/325 (9%)

Query: 8   QKIGEGSFG--KAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM-KHPNIV 64
           + IG GS+   K  + K+T    ++ +K I+      K + +   E+ +L    +HPNI+
Sbjct: 426 EDIGVGSYSVCKRCIHKATN--MEFAVKIID------KSKRDPTEEIEILLRYGQHPNII 477

Query: 65  QYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKI 124
             ++ +++   +Y+V +  +GG+L  +I  QK   F E +       I   ++++H + +
Sbjct: 478 TLKDVYDDGKYVYVVTELMKGGELLDKILRQK--FFSEREASAVLFTITKTVEYLHAQGV 535

Query: 125 LHRDIKSQNIFLTKDG----TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
           +HRD+K  NI    +     ++++ DFG A+ L +   L  T   T  +++PE+ + + Y
Sbjct: 536 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 595

Query: 181 NNKSDIWALGCVLYELCTLKHAFEAG---SMKNLVLKIISGSFPPVSLHY---SYDLRSL 234
           +   DIW+LG +LY + T    F  G   + + ++ +I SG F     ++   S   + L
Sbjct: 596 DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDL 655

Query: 235 VSQLFKRNPRDRPSVNSILEKGFIAK-------RIEKFLSPQLIAEEFCLKTFSKFGSQP 287
           VS++   +P  R +   +L   +I         ++ +  +P L+       T+S      
Sbjct: 656 VSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMA-ATYSALNRNQ 714

Query: 288 IPAKRPASGQNSISVMPAQKITKPA 312
            P   P            +KIT  A
Sbjct: 715 SPVLEPVGRSTLAQRRGIKKITSTA 739


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  147 bits (370), Expect = 8e-35
 Identities = 74/243 (30%), Positives = 141/243 (58%), Gaps = 6/243 (2%)

Query: 7   LQKIGEGSFGKAILVKST---EDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           L+ +G+GSFGK  LV+     + G  Y +K +  + +  ++R  ++ E  +LA++ HP +
Sbjct: 74  LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFV 133

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           V+   +F+  G LY+++D+  GGDLF R++  K V+F E+ +  +  ++ L L H+H   
Sbjct: 134 VKLHYAFQTEGKLYLILDFLRGGDLFTRLS--KEVMFTEEDVKFYLAELALGLDHLHSLG 191

Query: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
           I++RD+K +NI L ++G ++L DFG+++      + A +  GT  Y++PE+   + +++ 
Sbjct: 192 IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHS 251

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNP 243
           +D W+ G +++E+ T    F+    K  +  I+      +    S + +SL+  LFKRNP
Sbjct: 252 ADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKL-GMPQFLSTEAQSLLRALFKRNP 310

Query: 244 RDR 246
            +R
Sbjct: 311 ANR 313



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 78/324 (24%), Positives = 152/324 (46%), Gaps = 29/324 (8%)

Query: 4   YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           YV  + IG GS+ +           +Y +K I+ S+    E  E      +L   +HPNI
Sbjct: 427 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-----ILLRYGQHPNI 481

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           +  ++ +++   +Y+V +   GG+L  +I  QK   F E +       I   ++++H + 
Sbjct: 482 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQK--FFSEREASFVLHTIGKTVEYLHSQG 539

Query: 124 ILHRDIKSQNIFLTKDG----TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
           ++HRD+K  NI    +      +++ DFG A+ L +   L  T   T  +++PE+ + + 
Sbjct: 540 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG 599

Query: 180 YNNKSDIWALGCVLYELCTLKHAFEAG---SMKNLVLKIISGSFPPVSLHY---SYDLRS 233
           Y+   DIW+LG +LY +      F  G   + + ++ +I SG F     ++   S   + 
Sbjct: 600 YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 659

Query: 234 LVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCL------KTFSKF-GSQ 286
           LVS++   +P  R +   +L+  ++ ++ +K    QL  ++  L       T+S    S+
Sbjct: 660 LVSKMLHVDPHQRLTAKQVLQHPWVTQK-DKLPQSQLSHQDLQLVKGAMAATYSALNSSK 718

Query: 287 PIPAKRPASGQNSISVMPAQKITK 310
           P P  +P       S++  +++ K
Sbjct: 719 PTPQLKPIES----SILAQRRVRK 738


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  147 bits (370), Expect = 8e-35
 Identities = 74/243 (30%), Positives = 141/243 (58%), Gaps = 6/243 (2%)

Query: 7   LQKIGEGSFGKAILVKST---EDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           L+ +G+GSFGK  LV+     + G  Y +K +  + +  ++R  ++ E  +LA++ HP +
Sbjct: 65  LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFV 124

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           V+   +F+  G LY+++D+  GGDLF R++  K V+F E+ +  +  ++ L L H+H   
Sbjct: 125 VKLHYAFQTEGKLYLILDFLRGGDLFTRLS--KEVMFTEEDVKFYLAELALGLDHLHSLG 182

Query: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
           I++RD+K +NI L ++G ++L DFG+++      + A +  GT  Y++PE+   + +++ 
Sbjct: 183 IIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHS 242

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNP 243
           +D W+ G +++E+ T    F+    K  +  I+      +    S + +SL+  LFKRNP
Sbjct: 243 ADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKL-GMPQFLSTEAQSLLRALFKRNP 301

Query: 244 RDR 246
            +R
Sbjct: 302 ANR 304



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 78/324 (24%), Positives = 152/324 (46%), Gaps = 29/324 (8%)

Query: 4   YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           YV  + IG GS+ +           +Y +K I+ S+    E  E      +L   +HPNI
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-----ILLRYGQHPNI 472

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           +  ++ +++   +Y+V +   GG+L  +I  QK   F E +       I   ++++H + 
Sbjct: 473 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQK--FFSEREASFVLHTIGKTVEYLHSQG 530

Query: 124 ILHRDIKSQNIFLTKDG----TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
           ++HRD+K  NI    +      +++ DFG A+ L +   L  T   T  +++PE+ + + 
Sbjct: 531 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG 590

Query: 180 YNNKSDIWALGCVLYELCTLKHAFEAG---SMKNLVLKIISGSFPPVSLHY---SYDLRS 233
           Y+   DIW+LG +LY +      F  G   + + ++ +I SG F     ++   S   + 
Sbjct: 591 YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 650

Query: 234 LVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCL------KTFSKF-GSQ 286
           LVS++   +P  R +   +L+  ++ ++ +K    QL  ++  L       T+S    S+
Sbjct: 651 LVSKMLHVDPHQRLTAKQVLQHPWVTQK-DKLPQSQLSHQDLQLVKGAMAATYSALNSSK 709

Query: 287 PIPAKRPASGQNSISVMPAQKITK 310
           P P  +P       S++  +++ K
Sbjct: 710 PTPQLKPIES----SILAQRRVRK 729


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  147 bits (370), Expect = 8e-35
 Identities = 76/243 (31%), Positives = 141/243 (58%), Gaps = 6/243 (2%)

Query: 7   LQKIGEGSFGKAILV---KSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           L+ +G+GS+GK  LV   K ++ G+ Y +K +  + +  ++R  S+ E  +LA + HP I
Sbjct: 70  LKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFI 129

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           V+   +F+  G LY+++D+  GGDLF R++  K V+F E+ +  +  ++ LAL H+H   
Sbjct: 130 VKLHYAFQTEGKLYLILDFLRGGDLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLG 187

Query: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
           I++RD+K +NI L ++G +++ DFG+++      + A +  GT  Y++PE+   + +   
Sbjct: 188 IIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQS 247

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNP 243
           +D W+ G +++E+ T    F+    K  +  I+      +    S + +SL+  LFKRNP
Sbjct: 248 ADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL-GMPQFLSGEAQSLLRALFKRNP 306

Query: 244 RDR 246
            +R
Sbjct: 307 CNR 309



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 71/279 (25%), Positives = 141/279 (50%), Gaps = 23/279 (8%)

Query: 8   QKIGEGSFG--KAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65
           + IG GS+   K  + K+T+   +Y +K I+ S+    E  E      +L   +HPNI+ 
Sbjct: 427 EDIGVGSYSVCKRCVHKATDT--EYAVKIIDKSKRDPSEEIE-----ILLRYGQHPNIIT 479

Query: 66  YRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKIL 125
            ++ +++   +Y+VM+   GG+L  RI  Q+   F E +  D    I   + ++H + ++
Sbjct: 480 LKDVYDDGKFVYLVMELMRGGELLDRILRQR--YFSEREASDVLCTITKTMDYLHSQGVV 537

Query: 126 HRDIKSQNIFLTKDG----TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYN 181
           HRD+K  NI    +     ++++ DFG A+ L +   L  T   T  +++PE+ + + Y+
Sbjct: 538 HRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYD 597

Query: 182 NKSDIWALGCVLYELCTLKHAFEAG---SMKNLVLKIISGSFPPVSLHY---SYDLRSLV 235
              DIW+LG +LY +      F  G   + + ++ +I SG +     ++   S   + +V
Sbjct: 598 AACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 657

Query: 236 SQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEE 274
           S++   +P  R +   +L+  ++  R  ++LSP  ++ +
Sbjct: 658 SKMLHVDPHQRLTAMQVLKHPWVVNR--EYLSPNQLSRQ 694


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  147 bits (370), Expect = 8e-35
 Identities = 76/243 (31%), Positives = 141/243 (58%), Gaps = 6/243 (2%)

Query: 7   LQKIGEGSFGKAILV---KSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           L+ +G+GS+GK  LV   K ++ G+ Y +K +  + +  ++R  S+ E  +LA + HP I
Sbjct: 62  LKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFI 121

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           V+   +F+  G LY+++D+  GGDLF R++  K V+F E+ +  +  ++ LAL H+H   
Sbjct: 122 VKLHYAFQTEGKLYLILDFLRGGDLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLG 179

Query: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
           I++RD+K +NI L ++G +++ DFG+++      + A +  GT  Y++PE+   + +   
Sbjct: 180 IIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQS 239

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNP 243
           +D W+ G +++E+ T    F+    K  +  I+      +    S + +SL+  LFKRNP
Sbjct: 240 ADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL-GMPQFLSGEAQSLLRALFKRNP 298

Query: 244 RDR 246
            +R
Sbjct: 299 CNR 301



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 71/279 (25%), Positives = 141/279 (50%), Gaps = 23/279 (8%)

Query: 8   QKIGEGSFG--KAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65
           + IG GS+   K  + K+T+   +Y +K I+ S+    E  E      +L   +HPNI+ 
Sbjct: 419 EDIGVGSYSVCKRCVHKATDT--EYAVKIIDKSKRDPSEEIE-----ILLRYGQHPNIIT 471

Query: 66  YRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKIL 125
            ++ +++   +Y+VM+   GG+L  RI  Q+   F E +  D    I   + ++H + ++
Sbjct: 472 LKDVYDDGKFVYLVMELMRGGELLDRILRQR--YFSEREASDVLCTITKTMDYLHSQGVV 529

Query: 126 HRDIKSQNIFLTKDG----TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYN 181
           HRD+K  NI    +     ++++ DFG A+ L +   L  T   T  +++PE+ + + Y+
Sbjct: 530 HRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYD 589

Query: 182 NKSDIWALGCVLYELCTLKHAFEAG---SMKNLVLKIISGSFPPVSLHY---SYDLRSLV 235
              DIW+LG +LY +      F  G   + + ++ +I SG +     ++   S   + +V
Sbjct: 590 AACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 649

Query: 236 SQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEE 274
           S++   +P  R +   +L+  ++  R  ++LSP  ++ +
Sbjct: 650 SKMLHVDPHQRLTAMQVLKHPWVVNR--EYLSPNQLSRQ 686


>gi|41872374 polo-like kinase 3 [Homo sapiens]
          Length = 646

 Score =  145 bits (366), Expect = 2e-34
 Identities = 83/259 (32%), Positives = 143/259 (55%), Gaps = 6/259 (2%)

Query: 4   YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSK-EREESRREVAVLANMKHPN 62
           Y++ + +G+G F +      TE G  Y +K I  SR++   +RE+   E+ +  +++H +
Sbjct: 62  YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 121

Query: 63  IVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 122
           IV++   FE+  ++YI ++ C    L     A+  +L  E ++  +  QI   LK++H R
Sbjct: 122 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLL--EPEVRYYLRQILSGLKYLHQR 179

Query: 123 KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNN 182
            ILHRD+K  N F+T++  +++GDFG+A  L    +  +T  GTP Y++PE+   + +  
Sbjct: 180 GILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGP 239

Query: 183 KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFP-PVSLHYSYDLRSLVSQLFKR 241
           ++D+W+LGCV+Y L      FE   +K     I    +  P SL  S   R L++ + + 
Sbjct: 240 EADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASL--SLPARQLLAAILRA 297

Query: 242 NPRDRPSVNSILEKGFIAK 260
           +PRDRPS++ IL   F  K
Sbjct: 298 SPRDRPSIDQILRHDFFTK 316


>gi|93004081 polo-like kinase 2 [Homo sapiens]
          Length = 685

 Score =  144 bits (363), Expect = 5e-34
 Identities = 81/258 (31%), Positives = 143/258 (55%), Gaps = 6/258 (2%)

Query: 2   EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSK-EREESRREVAVLANMKH 60
           ++Y R + +G+G F K   +    + + Y  K I  SR++   +RE+  +E+ +   + H
Sbjct: 80  KRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHH 139

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
            ++VQ+   FE+  ++YI+++YC    +   + A+K  +  E ++  +  QI   LK++H
Sbjct: 140 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARK--VLTEPEVRYYLRQIVSGLKYLH 197

Query: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
           +++ILHRD+K  N F+ +   +++GDFG+A  L       RT  GTP YLSPE+   + +
Sbjct: 198 EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH 257

Query: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFP-PVSLHYSYDLRSLVSQLF 239
             +SDIWALGCV+Y +   +  FE  ++K     I    +  P SL      + L++ + 
Sbjct: 258 GCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSL--LAPAKHLIASML 315

Query: 240 KRNPRDRPSVNSILEKGF 257
            +NP DRPS++ I+   F
Sbjct: 316 SKNPEDRPSLDDIIRHDF 333


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  144 bits (362), Expect = 7e-34
 Identities = 76/243 (31%), Positives = 142/243 (58%), Gaps = 6/243 (2%)

Query: 7   LQKIGEGSFGKAILVKST---EDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
           L+ +G+GSFGK  LV+     + G+ Y +K +  + +  ++R  ++ E  +L  + HP I
Sbjct: 76  LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFI 135

Query: 64  VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
           V+   +F+  G LY+++D+  GGD+F R++  K VLF E+ +  +  ++ LAL H+H   
Sbjct: 136 VKLHYAFQTEGKLYLILDFLRGGDVFTRLS--KEVLFTEEDVKFYLAELALALDHLHQLG 193

Query: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
           I++RD+K +NI L + G ++L DFG+++      + A +  GT  Y++PE+   + ++  
Sbjct: 194 IVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQS 253

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNP 243
           +D W+ G +++E+ T    F+ G  +N  + +I  +   +    S + +SL+  LFKRNP
Sbjct: 254 ADWWSYGVLMFEMLTGTLPFQ-GKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNP 312

Query: 244 RDR 246
            +R
Sbjct: 313 ANR 315



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 69/271 (25%), Positives = 127/271 (46%), Gaps = 19/271 (7%)

Query: 2   EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM-KH 60
           E Y   + IG GS+             ++ +K I+      K + +   E+ +L    +H
Sbjct: 424 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIID------KSKRDPSEEIEILMRYGQH 477

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           PNI+  ++ F++   +Y+V D  +GG+L  RI  QK   F E +  D    I   + ++H
Sbjct: 478 PNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQK--CFSEREASDILYVISKTVDYLH 535

Query: 121 DRKILHRDIKSQNIFLTKDG----TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICE 176
            + ++HRD+K  NI    +     ++++ DFG A+ L     L  T   T  +++PE+  
Sbjct: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLM 595

Query: 177 NKPYNNKSDIWALGCVLYELCTLKHAFEAG---SMKNLVLKIISGSFPPVSLHY---SYD 230
            + Y+   DIW+LG + Y +      F  G   + + ++L+I +G F     ++   S  
Sbjct: 596 QQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDG 655

Query: 231 LRSLVSQLFKRNPRDRPSVNSILEKGFIAKR 261
            + L+S +   +P  R +   IL+  +I  R
Sbjct: 656 AKDLLSHMLHMDPHQRYTAEQILKHSWITHR 686


>gi|121114283 polo-like kinase 4 [Homo sapiens]
          Length = 970

 Score =  144 bits (362), Expect = 7e-34
 Identities = 77/252 (30%), Positives = 137/252 (54%), Gaps = 3/252 (1%)

Query: 10  IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKER-EESRREVAVLANMKHPNIVQYRE 68
           +G+GSF      +S   G +  IK I+   M      +  + EV +   +KHP+I++   
Sbjct: 18  LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 77

Query: 69  SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRD 128
            FE++  +Y+V++ C  G++  R    +   F E++   +  QI   + ++H   ILHRD
Sbjct: 78  YFEDSNYVYLVLEMCHNGEM-NRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRD 136

Query: 129 IKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWA 188
           +   N+ LT++  +++ DFG+A  L    E   T  GTP Y+SPEI     +  +SD+W+
Sbjct: 137 LTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWS 196

Query: 189 LGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPS 248
           LGC+ Y L   +  F+  ++KN + K++   +   S   S + + L+ QL +RNP DR S
Sbjct: 197 LGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSF-LSIEAKDLIHQLLRRNPADRLS 255

Query: 249 VNSILEKGFIAK 260
           ++S+L+  F+++
Sbjct: 256 LSSVLDHPFMSR 267


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  139 bits (349), Expect = 2e-32
 Identities = 79/247 (31%), Positives = 137/247 (55%), Gaps = 12/247 (4%)

Query: 7   LQKIGEGSFGKAILVKSTED---GRQYVIKEINISRM--SSKEREESRREVAVLANMKHP 61
           L+ +G+G +GK   V+  +    G+ Y +K +  +++  ++K+   +R E  +L ++KHP
Sbjct: 70  LRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHP 129

Query: 62  NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHD 121
            IV+   +F+  G LY++++   GG+LF  +  +   +F ED    +  +I LAL H+H 
Sbjct: 130 FIVELAYAFQTGGKLYLILECLSGGELFTHLEREG--IFLEDTACFYLAEITLALGHLHS 187

Query: 122 RKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYN 181
           + I++RD+K +NI L+  G ++L DFG+ +       +  T  GT  Y++PEI     +N
Sbjct: 188 QGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHN 247

Query: 182 NKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG--SFPPVSLHYSYDLRSLVSQLF 239
              D W+LG ++Y++ T    F A + K  + KII G  + PP   + + D R LV +  
Sbjct: 248 RAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPP---YLTPDARDLVKKFL 304

Query: 240 KRNPRDR 246
           KRNP  R
Sbjct: 305 KRNPSQR 311


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score =  138 bits (348), Expect = 3e-32
 Identities = 175/818 (21%), Positives = 350/818 (42%), Gaps = 135/818 (16%)

Query: 9   KIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRE 68
           ++G+G+FGK    ++ E       K I+    S +E E+   E+ +LA+  HPNIV+  +
Sbjct: 39  ELGDGAFGKVYKAQNKETSVLAAAKVIDTK--SEEELEDYMVEIDILASCDHPNIVKLLD 96

Query: 69  SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRD 128
           +F    +L+I++++C GG +   +  +      E QI     Q   AL ++HD KI+HRD
Sbjct: 97  AFYYENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRD 155

Query: 129 IKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEI--CE---NKPYNNK 183
           +K+ NI  T DG ++L DFG++     T++   + IGTPY+++PE+  CE   ++PY+ K
Sbjct: 156 LKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYK 215

Query: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVS--LHYSYDLRSLVSQLFKR 241
           +D+W+LG  L E+  ++      +   ++LKI     P ++    +S + +  + +  ++
Sbjct: 216 ADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEK 275

Query: 242 NPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKT------------FSKFGSQPIP 289
           N   R + + +L+  F+     K +  +LIAE     T                 S PIP
Sbjct: 276 NVDARWTTSQLLQHPFVTVDSNKPIR-ELIAEAKAEVTEEVEDGKEEDEEEETENSLPIP 334

Query: 290 AKRPASGQNSISVMPAQKITKPAA-------KYGIPLAYKKYGDKKLHEKKPLQKHKQAH 342
           A + AS   SI+     K+++ A        K     +  K   K L+EK    + ++A 
Sbjct: 335 ASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAV 394

Query: 343 QTPEKRVNTGE--------ERRKISEEAARKRR--LEFIE-------------KEKKQKD 379
           +   + +   +        +R  + +E  R++R  LE +               E K+ +
Sbjct: 395 EDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENN 454

Query: 380 QIISL-------MKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGEVKAPFLGSGGTI 432
            +I+L       +K+E+ K QEK+++          + N L    S E+K   L +   +
Sbjct: 455 IMITLETNIEHNLKSEEEKDQEKQQM----------FENKLIK--SEEIKDTILQTVDLV 502

Query: 433 APSSFSSRGQYEHYHA----IFDQMQQQRAEDNEAKWKREIYGRGLPERGILPGVRPGFP 488
           +  +       +   +      +  Q++  ED+  K ++++        G          
Sbjct: 503 SQETGEKEANIQAVDSEVGLTKEDTQEKLGEDD--KTQKDVISNTSDVIGTC-------- 552

Query: 489 YGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKREAMQNK 548
                     +A D+ + +    A   Q+N  ++  ++        ++ + +     +  
Sbjct: 553 ----------EAADVAQKVDEDSAEDTQSNDGKEVVEVG-------QKLINKPMVGPEAG 595

Query: 549 ARAEGHMVYLARLRQIRLQNFNERQQIKA--KLRGEKKEANHSEGQEGSEEADMRRKKIE 606
              E  +  +  + +I  +  N+ Q I +   +    +E   +EG+E +E +     ++ 
Sbjct: 596 GTKEVPIKEIVEMNEIE-EGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVR 654

Query: 607 SLKAHANAR--------AAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQ 658
           S+ A  + +        A+ +  Q+++++KE     KK  E  +V++  +   V  P   
Sbjct: 655 SVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSIN 714

Query: 659 HETGGSPSKQQMRSVISVTSAL-------KEVGVDSSLTDTRET---------SEEMQKT 702
             +    +K+++ S+    + L       KE   DS    T +T         S  + KT
Sbjct: 715 INSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKT 774

Query: 703 NNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINV 740
            ++ S   +  RR  + LK     K ++ + D  E++V
Sbjct: 775 KDSGSISLQETRRQKKTLK-----KTRKFIVDGVEVSV 807



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 48/248 (19%), Positives = 101/248 (40%), Gaps = 31/248 (12%)

Query: 504  RKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR-KREAMQNKARAEGHMVYLARLR 562
            R+ L+ L+ + K+    +Q  QL  +  +Q E+  +R ++E M  K + +  +  L + +
Sbjct: 828  RQELRELRFLQKEEQRAQQ--QLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQ 885

Query: 563  QIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQ 622
            +  ++     Q+   +LR E K     + +E S+  +M + + + +          L+++
Sbjct: 886  KQTIERLE--QEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKE 943

Query: 623  LERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKE 682
            L ++RKE   + +   E+  V K            Q E  GS  K   +    + +  +E
Sbjct: 944  LMKRRKEELAQSQHAQEQEFVQKQ-----------QQELDGSLKKIIQQQKAELANIERE 992

Query: 683  VGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHE 742
                            +      + ++   +  L E    ++ +  KQ L D + +  H+
Sbjct: 993  C---------------LNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQ 1037

Query: 743  DAKEHEKE 750
              K HEKE
Sbjct: 1038 LLKRHEKE 1045



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 65/303 (21%), Positives = 129/303 (42%), Gaps = 51/303 (16%)

Query: 878  SEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSAD 937
            +EA  +++ ++E   EE ++ ETE    P   +K  S     +D+ I+  +E K +Q+A 
Sbjct: 305  AEAKAEVTEEVEDGKEEDEEEETEN-SLPIPASKRAS-----SDLSIASSEEDKLSQNA- 357

Query: 938  RITIQENEVSEDGVSSTVDQLSD--IHIEPGTNDSQHSKCDV-----DKSVQPEPFFHK- 989
               I E+   +   S++ D+L+   ++ +P T++ + +  D+     D  ++     H  
Sbjct: 358  --CILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDR 415

Query: 990  --VVHSEHLNLVPQVQSV-QCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPK 1046
              V+        P+++++     +E+    S S        +N+++I L T     N   
Sbjct: 416  TAVIKENEREKRPKLENLPDTEDQETVDINSVSE-----GKENNIMITLET-----NIEH 465

Query: 1047 MLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDL 1106
             L++    D  K               Q   E   I+ E IK+    + D+V +ET    
Sbjct: 466  NLKSEEEKDQEK---------------QQMFENKLIKSEEIKDTILQTVDLVSQETGEKE 510

Query: 1107 QELQASMEQL------LREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESAL 1160
              +QA   ++       +E+ GE+   +++ +   SDV  T    DVA + D  S+E   
Sbjct: 511  ANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQ 570

Query: 1161 NEE 1163
            + +
Sbjct: 571  SND 573


>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
           sapiens]
          Length = 351

 Score =  138 bits (348), Expect = 3e-32
 Identities = 100/315 (31%), Positives = 158/315 (50%), Gaps = 38/315 (12%)

Query: 2   EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRM-SSKEREESRREVAVLANMKH 60
           +++ RL+ +G GSFG+ +LV+  E G  Y +K +N  ++   K+ E    E  +L  +  
Sbjct: 42  DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101

Query: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
           P +V+ + SF++N  LY+VM+Y  GG++F R+  Q+   F E     +  Q+ LA++++H
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRL--QRVGRFSEPHACFYAAQVVLAVQYLH 159

Query: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
              ++HRD+K +N+ + + G +Q+ DFG A+ +        T  GTP YL+PEI  +K Y
Sbjct: 160 SLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTW---TLCGTPEYLAPEIILSKGY 216

Query: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG--SFP-PVSLHYSYDLRSLVS- 236
           N   D WALG ++YE+      F A     +  KI+SG   FP  +S    + LRSL+  
Sbjct: 217 NKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQV 276

Query: 237 QLFKRNPRDRPSVN--------------SILEKGFIAKRIEKFLSP-------------- 268
            L KR    R  V               +I EK   A  I K+  P              
Sbjct: 277 DLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEEL 336

Query: 269 QLIAEEFCLKTFSKF 283
           ++   E C K FS+F
Sbjct: 337 RISINEKCAKEFSEF 351


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  137 bits (346), Expect = 5e-32
 Identities = 79/243 (32%), Positives = 136/243 (55%), Gaps = 11/243 (4%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSS-KEREESRREVAVLANMK 59
           ++++ R++ +G GSFG+ +LVK  E G  Y +K ++  ++   K+ E +  E  +L  + 
Sbjct: 33  LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92

Query: 60  HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHV 119
            P +V+   SF++N +LY+VM+Y  GG++F  +  ++   F E     +  QI L  +++
Sbjct: 93  FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQIVLTFEYL 150

Query: 120 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
           H   +++RD+K +N+ + + G +Q+ DFG A+ +        T  GTP YL+PEI  +K 
Sbjct: 151 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEIILSKG 207

Query: 180 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS--FPPVSLHYSYDLRSLVSQ 237
           YN   D WALG ++YE+      F A     +  KI+SG   FP    H+S DL+ L+  
Sbjct: 208 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS---HFSSDLKDLLRN 264

Query: 238 LFK 240
           L +
Sbjct: 265 LLQ 267


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  137 bits (346), Expect = 5e-32
 Identities = 79/243 (32%), Positives = 136/243 (55%), Gaps = 11/243 (4%)

Query: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSS-KEREESRREVAVLANMK 59
           ++++ R++ +G GSFG+ +LVK  E G  Y +K ++  ++   K+ E +  E  +L  + 
Sbjct: 41  LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100

Query: 60  HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHV 119
            P +V+   SF++N +LY+VM+Y  GG++F  +  ++   F E     +  QI L  +++
Sbjct: 101 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQIVLTFEYL 158

Query: 120 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
           H   +++RD+K +N+ + + G +Q+ DFG A+ +        T  GTP YL+PEI  +K 
Sbjct: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEIILSKG 215

Query: 180 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS--FPPVSLHYSYDLRSLVSQ 237
           YN   D WALG ++YE+      F A     +  KI+SG   FP    H+S DL+ L+  
Sbjct: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS---HFSSDLKDLLRN 272

Query: 238 LFK 240
           L +
Sbjct: 273 LLQ 275


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,685,088
Number of Sequences: 37866
Number of extensions: 2454602
Number of successful extensions: 19190
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 815
Number of HSP's successfully gapped in prelim test: 735
Number of HSP's that attempted gapping in prelim test: 10442
Number of HSP's gapped (non-prelim): 6053
length of query: 1258
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1144
effective length of database: 13,930,794
effective search space: 15936828336
effective search space used: 15936828336
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.