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Search of human proteins with 41327712
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
(304 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 627 e-180
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 415 e-116
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 345 2e-95
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 91 2e-18
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 82 4e-16
gi|39930351 dynamin binding protein [Homo sapiens] 67 3e-11
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 63 3e-10
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 63 3e-10
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 62 8e-10
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 57 2e-08
gi|11321634 CD2-associated protein [Homo sapiens] 55 6e-08
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 55 1e-07
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 55 1e-07
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 55 1e-07
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 55 1e-07
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 55 1e-07
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 55 1e-07
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 55 1e-07
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 55 1e-07
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] 55 1e-07
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] 55 1e-07
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] 55 1e-07
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] 55 1e-07
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 54 2e-07
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 54 2e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 54 2e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 54 2e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 54 2e-07
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 53 3e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 52 5e-07
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 627 bits (1617), Expect = e-180
Identities = 304/304 (100%), Positives = 304/304 (100%)
Query: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
Sbjct: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
Query: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
Sbjct: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
Query: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
Sbjct: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
Query: 181 MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA 240
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
Sbjct: 181 MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA 240
Query: 241 RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD 300
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
Sbjct: 241 RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD 300
Query: 301 EDFS 304
EDFS
Sbjct: 301 EDFS 304
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 415 bits (1066), Expect = e-116
Identities = 203/203 (100%), Positives = 203/203 (100%)
Query: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
Sbjct: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
Query: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
Sbjct: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
Query: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
Sbjct: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
Query: 181 MIPVPYVEKYRPASASVSALIGG 203
MIPVPYVEKYRPASASVSALIGG
Sbjct: 181 MIPVPYVEKYRPASASVSALIGG 203
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 345 bits (886), Expect = 2e-95
Identities = 184/323 (56%), Positives = 217/323 (67%), Gaps = 45/323 (13%)
Query: 2 AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61
+ FDS +RS+WY G +SRQEA LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI
Sbjct: 3 SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62
Query: 62 INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120
INS R R +IGDQEFD LPALLEFYKIHYLDTTTLIEP R
Sbjct: 63 INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105
Query: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
S + ++ EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A +
Sbjct: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165
Query: 175 SEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPG-PYAQPSVNTPLP-- 231
+G+ GMIPVPYVEK +S G + G PEP YAQP TPLP
Sbjct: 166 KDGRVGMIPVPYVEKLVRSSPH------GKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAV 219
Query: 232 ------------NLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGEC 279
+ QNGP++A+ IQKRVP AYDKTALALEVG++VKVT++N++GQWEGE
Sbjct: 220 SGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEV 279
Query: 280 NGKRGHFPFTHVRLLDQQNPDED 302
NG++G FPFTHV++ D QNPDE+
Sbjct: 280 NGRKGLFPFTHVKIFDPQNPDEN 302
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 90.5 bits (223), Expect = 2e-18
Identities = 52/177 (29%), Positives = 92/177 (51%), Gaps = 24/177 (13%)
Query: 13 WYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
WY GR+SRQ A +L + H G FL+R+S +SPG++ +SV+ +V H+ +
Sbjct: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLRE------ 113
Query: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQ 131
+ + + +++F+SL L++FY+ TTT+ + + +L+
Sbjct: 114 -----------ASGKYFLWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKS 157
Query: 132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
A + +A FDF+ D L F++GDI+ + ++P+ WW S G+ G P YV+
Sbjct: 158 PGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR-SCGRVGFFPRSYVQ 213
Score = 40.8 bits (94), Expect = 0.002
Identities = 17/49 (34%), Positives = 27/49 (55%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+ F + ++L F KGD L+I + ++Q W + G G IP Y+
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 82.4 bits (202), Expect = 4e-16
Identities = 53/190 (27%), Positives = 94/190 (49%), Gaps = 36/190 (18%)
Query: 4 NFDSEERSSWYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYII 62
N+ + W++G++ R +A +L QRH G FL+R+S ++PGD+ LSV + V H+ +
Sbjct: 51 NYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110
Query: 63 NSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSR 122
G + + +F+SL L+++++ VSR++
Sbjct: 111 LRDGA-----------------GKYFLWVVKFNSLNELVDYHRS---------TSVSRNQ 144
Query: 123 QGSGVILRQ-----EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEG 177
Q + LR ++ YV+ALFDF+ ++ +L F++GD + + D + WW G
Sbjct: 145 Q---IFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA-CHG 200
Query: 178 KRGMIPVPYV 187
+ GM P YV
Sbjct: 201 QTGMFPRNYV 210
Score = 44.7 bits (104), Expect = 1e-04
Identities = 19/50 (38%), Positives = 31/50 (62%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
A +DF +++L FK+GDIL++ ++ +Q W + GK G IP Y+E
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/192 (28%), Positives = 82/192 (42%), Gaps = 21/192 (10%)
Query: 119 SRSRQGSGVILRQEEAEY----VRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
S+SRQ + EY RAL + +E+L F++GD++ I PE W+ E
Sbjct: 128 SQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGE- 186
Query: 175 SEGKRGMIPVPYVEKYRPASASVSALIGGNQE-----GSHPQPLGGPEPGPYAQPSVNTP 229
EG+RG+ P +VE P ++ GNQ+ G P+G E G P +
Sbjct: 187 LEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIG----PDEDEE 242
Query: 230 LPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFT 289
P +Y Q PN D EVG+ +++ G EG G+ G FP+
Sbjct: 243 EPGTYGVALYR--FQALEPNELD-----FEVGDKIRILATLEDGWLEGSLKGRTGIFPYR 295
Query: 290 HVRLLDQQNPDE 301
V+L +E
Sbjct: 296 FVKLCPDTRVEE 307
Score = 35.0 bits (79), Expect = 0.082
Identities = 42/164 (25%), Positives = 59/164 (35%), Gaps = 42/164 (25%)
Query: 132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYR 191
E VRA+FDF + E+LP GDI+ + +E +W E G P +VE
Sbjct: 2 EAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDE-FWLLGKKEDVTGQFPSSFVE--- 57
Query: 192 PASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAY 251
+P+L+ G I +
Sbjct: 58 -----------------------------------IVTIPSLKEGERLFVCICEFTSQEL 82
Query: 252 DKTALALEVGELVKVTKINVSGQWEG-ECNGKRGHFPFTHVRLL 294
D L L G+LV + I +G +G C G RG FP + VR L
Sbjct: 83 DN--LPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVREL 124
Score = 34.7 bits (78), Expect = 0.11
Identities = 37/166 (22%), Positives = 62/166 (37%), Gaps = 27/166 (16%)
Query: 129 LRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
L++ E +V + +F + ++LP +GD++ + P W G RG P V
Sbjct: 64 LKEGERLFV-CICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVR 122
Query: 189 KYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVP 248
+ +S S + S +P G AR +
Sbjct: 123 ELCLSSQS----------------------RQWHSQSALFQIPEYSMG--QARALMGL-- 156
Query: 249 NAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLL 294
+A L G+++ + + G +EGE G+RG FP V LL
Sbjct: 157 SAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 63.2 bits (152), Expect = 3e-10
Identities = 49/207 (23%), Positives = 81/207 (39%), Gaps = 42/207 (20%)
Query: 6 DSEERSSWYWGRLSRQEAV-ALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS 64
++ E WY L+R +A L++ R G FLVR + P Y +S ++ H +
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGKIKHCRVQQ 719
Query: 65 SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY---------KIHYLDTTTLI 115
G + +G+ EFDSL L+ +Y K+ Y +
Sbjct: 720 EG------------------QTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEAL 761
Query: 116 EPVSRSRQGSGVILRQEEAEY-------------VRALFDFNGNDEEDLPFKKGDILRIR 162
E + + G + + V+ALFD+ E++L F K I++
Sbjct: 762 EKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNV 821
Query: 163 DKPEEQWWNAEDSEGKRGMIPVPYVEK 189
+K E WW + K+ P YVE+
Sbjct: 822 EKQEGGWWRGDYGGKKQLWFPSNYVEE 848
Score = 36.2 bits (82), Expect = 0.037
Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 23/85 (27%)
Query: 3 GNFDSEE------------RSSWYWGRLS-----RQEAVALLQ------GQRHGVFLVRD 39
GN D EE W+ G+L R A LL G G FLVR+
Sbjct: 528 GNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRE 587
Query: 40 SSTSPGDYVLSVSENSRVSHYIINS 64
S T GDY LS N +V H I+S
Sbjct: 588 SETFVGDYTLSFWRNGKVQHCRIHS 612
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 63.2 bits (152), Expect = 3e-10
Identities = 49/207 (23%), Positives = 81/207 (39%), Gaps = 42/207 (20%)
Query: 6 DSEERSSWYWGRLSRQEAV-ALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS 64
++ E WY L+R +A L++ R G FLVR + P Y +S ++ H +
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGKIKHCRVQQ 719
Query: 65 SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY---------KIHYLDTTTLI 115
G + +G+ EFDSL L+ +Y K+ Y +
Sbjct: 720 EG------------------QTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEAL 761
Query: 116 EPVSRSRQGSGVILRQEEAEY-------------VRALFDFNGNDEEDLPFKKGDILRIR 162
E + + G + + V+ALFD+ E++L F K I++
Sbjct: 762 EKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNV 821
Query: 163 DKPEEQWWNAEDSEGKRGMIPVPYVEK 189
+K E WW + K+ P YVE+
Sbjct: 822 EKQEGGWWRGDYGGKKQLWFPSNYVEE 848
Score = 36.2 bits (82), Expect = 0.037
Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 23/85 (27%)
Query: 3 GNFDSEE------------RSSWYWGRLS-----RQEAVALLQ------GQRHGVFLVRD 39
GN D EE W+ G+L R A LL G G FLVR+
Sbjct: 528 GNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRE 587
Query: 40 SSTSPGDYVLSVSENSRVSHYIINS 64
S T GDY LS N +V H I+S
Sbjct: 588 SETFVGDYTLSFWRNGKVQHCRIHS 612
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 61.6 bits (148), Expect = 8e-10
Identities = 54/192 (28%), Positives = 80/192 (41%), Gaps = 38/192 (19%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
WY G + R A ++L + G FLVR ++ +S+ N V H I ++
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTA------- 723
Query: 73 PSPAQPPPGVSPSRLRIGDQE-FDSLPALLEFYK-------IHYLDTTTLI---EP---- 117
RI +++ F L L+EFY+ LDTT EP
Sbjct: 724 -----------EGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRT 772
Query: 118 VSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEG 177
+SR GS +A Y DF D +L K+GDI++I +K +Q W + G
Sbjct: 773 ISRPAVGSTKYFGTAKARY-----DFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYG 827
Query: 178 KRGMIPVPYVEK 189
+ G P YVE+
Sbjct: 828 RVGWFPANYVEE 839
Score = 34.3 bits (77), Expect = 0.14
Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 9/56 (16%)
Query: 250 AYDKTALALEVGELVKV-TKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 304
A D++ L+L+ G+++K+ K G W GE G+ G FP +V +ED+S
Sbjct: 795 ARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV--------EEDYS 842
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 57.0 bits (136), Expect = 2e-08
Identities = 54/201 (26%), Positives = 85/201 (42%), Gaps = 46/201 (22%)
Query: 114 LIEPVSRSRQGSGVILRQEEAE-------------YVRALFDFNGNDEEDLPFKKGDILR 160
L++ + + +GSG R A + + F ++ ++L + G+I+
Sbjct: 52 LVQEIPETLRGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVE 111
Query: 161 IRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPE--- 217
+ + E+ WW + + G+ G P +VE S P LG P+
Sbjct: 112 MIKEIEDGWWLGKKN-GQLGAFPSNFVELL----------------DSGPPSLGNPDMPS 154
Query: 218 --PGPYAQPSVNT-----PLPNLQ--NGPIYARVIQKRVPNAYDKTALALEVGELVKVTK 268
PGP P +++ P LQ + P RV+ P A D+ LAL G++VKV
Sbjct: 155 VSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDE--LALRRGDVVKVLS 212
Query: 269 INVS--GQWEGECNGKRGHFP 287
G WEGEC G+RG FP
Sbjct: 213 KTTEDKGWWEGECQGRRGVFP 233
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/167 (26%), Positives = 67/167 (40%), Gaps = 28/167 (16%)
Query: 137 VRALFDFNGNDEEDLPFKKGDILR-IRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASA 195
V L + E++L GD++R +R P W E G+ G+ P V++
Sbjct: 3 VLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFG-GRYGLFPERLVQE------ 55
Query: 196 SVSALIGGNQEGSHPQPL---GGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYD 252
+ + G+ E P+ G P P Q + +V P D
Sbjct: 56 -IPETLRGSGEARRPRCARRRGHPAKHPRPQR--------------WCKVNFSYSPEQAD 100
Query: 253 KTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNP 299
+ L L+ GE+V++ K G W G+ NG+ G FP V LLD P
Sbjct: 101 E--LKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 55.5 bits (132), Expect = 6e-08
Identities = 41/175 (23%), Positives = 82/175 (46%), Gaps = 24/175 (13%)
Query: 141 FDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY---------- 190
+D++ +++L + G+I+R K +E+ W + G+RGM P +V++
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 191 ----RPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKR 246
R +V++L+ + ++ P GG +P P + ++ Q +V+ +
Sbjct: 68 LPIKRERHGNVASLV--QRISTYGLPAGGIQPHPQTK-NIKKKTKKRQ-----CKVLFEY 119
Query: 247 VPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDE 301
+P D+ L L+VG+++ + + G W G N K G FP V+ L+ + E
Sbjct: 120 IPQNEDE--LELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGE 172
Score = 43.9 bits (102), Expect = 2e-04
Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRI--RDKPEEQWWNAEDSEGKRGMIP 183
EY R LF + G +E++L FK+G+I+ + ++ E WW E GK G+ P
Sbjct: 272 EYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGE-LNGKEGVFP 321
Score = 39.3 bits (90), Expect = 0.004
Identities = 18/62 (29%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 128 ILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
I ++ + + LF++ +E++L K GDI+ I ++ EE WW+ K G+ P +V
Sbjct: 104 IKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSG-TLNNKLGLFPSNFV 162
Query: 188 EK 189
++
Sbjct: 163 KE 164
Score = 37.0 bits (84), Expect = 0.022
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 256 LALEVGELVK-VTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 304
L + VGE+++ V K+ G EGE NG+RG FP V+ + ++ +D S
Sbjct: 18 LTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Score = 28.9 bits (63), Expect = 5.9
Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 5/43 (11%)
Query: 250 AYDKT---ALALEVGELVKVT--KINVSGQWEGECNGKRGHFP 287
AY+ T L + GE++ + + +G W GE NGK G FP
Sbjct: 279 AYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFP 321
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 247 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 301
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 302 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 332
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 333 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 412 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 463
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 464 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 491
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 759 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 813
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 814 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 844
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 845 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 924 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 975
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 976 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 1003
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 579 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 633
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 634 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 664
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 665 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 744 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 795
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 796 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 823
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 416 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 470
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 471 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 501
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 502 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 581 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 632
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 633 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 660
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 486 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 540
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 541 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 571
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 572 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 651 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 702
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 703 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 730
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 399 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 453
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 454 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 484
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 564 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 615
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 616 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 643
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 855 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 909
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 910 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 940
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 941 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 1020 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 1071
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 1099
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)
Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
R R+G+ ++E +A++DF ++L FKKGD + I K ++ W+ E G+
Sbjct: 421 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 475
Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
G+ P+ YVEK P PE AQP+ P P Q G I
Sbjct: 476 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 506
Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
I K NA L+L G+ V + K +EG+ G ++G FP ++V ++
Sbjct: 507 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 563
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
+IH L + PV + QG G E +AL+++ +E++L ++ D++ +
Sbjct: 586 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 637
Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
+K ++ W+ K G P YV++
Sbjct: 638 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 665
>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
Length = 614
Score = 54.7 bits (130), Expect = 1e-07
Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 94 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 152
Query: 195 ASVSALIGGNQE 206
+ G++E
Sbjct: 153 EGQESSEEGSEE 164
>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
Length = 677
Score = 54.7 bits (130), Expect = 1e-07
Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214
Query: 195 ASVSALIGGNQE 206
+ G++E
Sbjct: 215 EGQESSEEGSEE 226
>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
Length = 732
Score = 54.7 bits (130), Expect = 1e-07
Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214
Query: 195 ASVSALIGGNQE 206
+ G++E
Sbjct: 215 EGQESSEEGSEE 226
>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
Length = 733
Score = 54.7 bits (130), Expect = 1e-07
Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214
Query: 195 ASVSALIGGNQE 206
+ G++E
Sbjct: 215 EGQESSEEGSEE 226
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 53.9 bits (128), Expect = 2e-07
Identities = 64/259 (24%), Positives = 103/259 (39%), Gaps = 53/259 (20%)
Query: 38 RDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSL 97
R+S +PGD L+ EN R + + G P S + P + ++ + F +
Sbjct: 501 RESDGAPGD--LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHF--I 556
Query: 98 PALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGD 157
PA YL++T E R R +E RA FDF ++LP +KGD
Sbjct: 557 PA-------DYLEST---EEFIRRRHDD------KEMRPARAKFDFKAQTLKELPLQKGD 600
Query: 158 ILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPE 217
I+ I + ++ W+ E G+ G+ P Y+E PA
Sbjct: 601 IVYIYKQIDQNWYEGE-HHGRVGIFPRTYIELLPPAEK---------------------- 637
Query: 218 PGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEG 277
AQP TP+ L+ Y I K N + ++ GE + + + +EG
Sbjct: 638 ----AQPKKLTPVQVLE----YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 689
Query: 278 ECNG--KRGHFPFTHVRLL 294
G ++G FP T+V ++
Sbjct: 690 RIPGTSRQGIFPITYVDVI 708
Score = 28.5 bits (62), Expect = 7.7
Identities = 13/52 (25%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
Query: 138 RALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR-GMIPVPYVE 188
+AL+ + ++++L + GDI+ + +K ++ W+ K+ G P YV+
Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 53.9 bits (128), Expect = 2e-07
Identities = 64/259 (24%), Positives = 103/259 (39%), Gaps = 53/259 (20%)
Query: 38 RDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSL 97
R+S +PGD L+ EN R + + G P S + P + ++ + F +
Sbjct: 369 RESDGAPGD--LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHF--I 424
Query: 98 PALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGD 157
PA YL++T E R R +E RA FDF ++LP +KGD
Sbjct: 425 PA-------DYLEST---EEFIRRRHDD------KEMRPARAKFDFKAQTLKELPLQKGD 468
Query: 158 ILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPE 217
I+ I + ++ W+ E G+ G+ P Y+E PA
Sbjct: 469 IVYIYKQIDQNWYEGE-HHGRVGIFPRTYIELLPPAEK---------------------- 505
Query: 218 PGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEG 277
AQP TP+ L+ Y I K N + ++ GE + + + +EG
Sbjct: 506 ----AQPKKLTPVQVLE----YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 557
Query: 278 ECNG--KRGHFPFTHVRLL 294
G ++G FP T+V ++
Sbjct: 558 RIPGTSRQGIFPITYVDVI 576
Score = 28.5 bits (62), Expect = 7.7
Identities = 13/52 (25%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
Query: 138 RALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR-GMIPVPYVE 188
+AL+ + ++++L + GDI+ + +K ++ W+ K+ G P YV+
Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 53.5 bits (127), Expect = 2e-07
Identities = 26/48 (54%), Positives = 32/48 (66%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
W+ G++S QEAV LQ G+FLVR+S+ PGDYVL VS V HY
Sbjct: 81 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 128
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 53.5 bits (127), Expect = 2e-07
Identities = 26/48 (54%), Positives = 32/48 (66%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
W+ G++S QEAV LQ G+FLVR+S+ PGDYVL VS V HY
Sbjct: 123 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 170
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 53.5 bits (127), Expect = 2e-07
Identities = 26/48 (54%), Positives = 32/48 (66%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
W+ G++S QEAV LQ G+FLVR+S+ PGDYVL VS V HY
Sbjct: 122 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 169
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 64 SSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQ 123
S G PP P P Q +P+ G S P F T + ++ SR
Sbjct: 130 SPGGSPPARPIPGQ---SAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRT 186
Query: 124 GSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIP 183
Y +AL+ + G + DL F KGDI+ +R K +EQW++ E G +G +P
Sbjct: 187 APAA-KNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGE-LHGTQGFLP 244
Query: 184 VPYVEKYRP 192
Y++ +P
Sbjct: 245 ASYIQCIQP 253
Score = 33.5 bits (75), Expect = 0.24
Identities = 15/57 (26%), Positives = 28/57 (49%), Gaps = 1/57 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAE-DSEGKRGMIPVPYVEKY 190
E R + + E ++ K+GDI+ + K E+ W+ G+ G+ P +VE +
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF 882
Score = 28.9 bits (63), Expect = 5.9
Identities = 19/77 (24%), Positives = 32/77 (41%), Gaps = 1/77 (1%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWW-NAEDSEGKRGMIPVPYVEKYRPASASV 197
AL+ + ++L KG++ R+ +K ++ W+ A G G+ P YV A
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGG 530
Query: 198 SALIGGNQEGSHPQPLG 214
+ N G P G
Sbjct: 531 AGPPRNNVVGGSPLAKG 547
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 52.4 bits (124), Expect = 5e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Score = 30.4 bits (67), Expect = 2.0
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ + W+ S+ +G +P Y+
Sbjct: 99 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,795,454
Number of Sequences: 37866
Number of extensions: 884675
Number of successful extensions: 9380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 340
Number of HSP's successfully gapped in prelim test: 192
Number of HSP's that attempted gapping in prelim test: 7254
Number of HSP's gapped (non-prelim): 2029
length of query: 304
length of database: 18,247,518
effective HSP length: 102
effective length of query: 202
effective length of database: 14,385,186
effective search space: 2905807572
effective search space used: 2905807572
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.