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Search of human proteins with 41327710
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
(204 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 417 e-117
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 415 e-116
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 231 3e-61
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 91 9e-19
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 82 2e-16
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 63 2e-10
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 63 2e-10
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 62 4e-10
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] 54 9e-08
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] 54 9e-08
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] 54 9e-08
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] 54 9e-08
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 54 1e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 54 1e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 54 1e-07
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 53 2e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 52 3e-07
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 52 3e-07
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 52 3e-07
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 52 3e-07
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 52 3e-07
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 52 3e-07
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 52 3e-07
gi|187475373 c-src tyrosine kinase [Homo sapiens] 52 5e-07
gi|4758078 c-src tyrosine kinase [Homo sapiens] 52 5e-07
gi|194239668 SHC (Src homology 2 domain containing) transforming... 52 5e-07
gi|194239664 SHC (Src homology 2 domain containing) transforming... 52 5e-07
gi|194239662 SHC (Src homology 2 domain containing) transforming... 52 5e-07
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 52 5e-07
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 52 5e-07
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 417 bits (1071), Expect = e-117
Identities = 204/204 (100%), Positives = 204/204 (100%)
Query: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
Sbjct: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
Query: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
Sbjct: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
Query: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
Sbjct: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
Query: 181 MIPVPYVEKYRPASASVSALIGGR 204
MIPVPYVEKYRPASASVSALIGGR
Sbjct: 181 MIPVPYVEKYRPASASVSALIGGR 204
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 415 bits (1066), Expect = e-116
Identities = 203/203 (100%), Positives = 203/203 (100%)
Query: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
Sbjct: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
Query: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
Sbjct: 61 IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
Query: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
Sbjct: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
Query: 181 MIPVPYVEKYRPASASVSALIGG 203
MIPVPYVEKYRPASASVSALIGG
Sbjct: 181 MIPVPYVEKYRPASASVSALIGG 203
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 231 bits (589), Expect = 3e-61
Identities = 121/195 (62%), Positives = 137/195 (70%), Gaps = 24/195 (12%)
Query: 2 AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61
+ FDS +RS+WY G +SRQEA LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI
Sbjct: 3 SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62
Query: 62 INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120
INS R R +IGDQEFD LPALLEFYKIHYLDTTTLIEP R
Sbjct: 63 INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105
Query: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
S + ++ EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A +
Sbjct: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165
Query: 175 SEGKRGMIPVPYVEK 189
+G+ GMIPVPYVEK
Sbjct: 166 KDGRVGMIPVPYVEK 180
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 90.5 bits (223), Expect = 9e-19
Identities = 52/177 (29%), Positives = 92/177 (51%), Gaps = 24/177 (13%)
Query: 13 WYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
WY GR+SRQ A +L + H G FL+R+S +SPG++ +SV+ +V H+ +
Sbjct: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLRE------ 113
Query: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQ 131
+ + + +++F+SL L++FY+ TTT+ + + +L+
Sbjct: 114 -----------ASGKYFLWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKS 157
Query: 132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
A + +A FDF+ D L F++GDI+ + ++P+ WW S G+ G P YV+
Sbjct: 158 PGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR-SCGRVGFFPRSYVQ 213
Score = 40.8 bits (94), Expect = 8e-04
Identities = 17/49 (34%), Positives = 27/49 (55%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+ F + ++L F KGD L+I + ++Q W + G G IP Y+
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 82.4 bits (202), Expect = 2e-16
Identities = 53/190 (27%), Positives = 94/190 (49%), Gaps = 36/190 (18%)
Query: 4 NFDSEERSSWYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYII 62
N+ + W++G++ R +A +L QRH G FL+R+S ++PGD+ LSV + V H+ +
Sbjct: 51 NYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110
Query: 63 NSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSR 122
G + + +F+SL L+++++ VSR++
Sbjct: 111 LRDGA-----------------GKYFLWVVKFNSLNELVDYHRS---------TSVSRNQ 144
Query: 123 QGSGVILRQ-----EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEG 177
Q + LR ++ YV+ALFDF+ ++ +L F++GD + + D + WW G
Sbjct: 145 Q---IFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA-CHG 200
Query: 178 KRGMIPVPYV 187
+ GM P YV
Sbjct: 201 QTGMFPRNYV 210
Score = 44.7 bits (104), Expect = 6e-05
Identities = 19/50 (38%), Positives = 31/50 (62%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
A +DF +++L FK+GDIL++ ++ +Q W + GK G IP Y+E
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 63.2 bits (152), Expect = 2e-10
Identities = 49/207 (23%), Positives = 81/207 (39%), Gaps = 42/207 (20%)
Query: 6 DSEERSSWYWGRLSRQEAV-ALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS 64
++ E WY L+R +A L++ R G FLVR + P Y +S ++ H +
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGKIKHCRVQQ 719
Query: 65 SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY---------KIHYLDTTTLI 115
G + +G+ EFDSL L+ +Y K+ Y +
Sbjct: 720 EG------------------QTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEAL 761
Query: 116 EPVSRSRQGSGVILRQEEAEY-------------VRALFDFNGNDEEDLPFKKGDILRIR 162
E + + G + + V+ALFD+ E++L F K I++
Sbjct: 762 EKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNV 821
Query: 163 DKPEEQWWNAEDSEGKRGMIPVPYVEK 189
+K E WW + K+ P YVE+
Sbjct: 822 EKQEGGWWRGDYGGKKQLWFPSNYVEE 848
Score = 36.2 bits (82), Expect = 0.020
Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 23/85 (27%)
Query: 3 GNFDSEE------------RSSWYWGRLS-----RQEAVALLQ------GQRHGVFLVRD 39
GN D EE W+ G+L R A LL G G FLVR+
Sbjct: 528 GNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRE 587
Query: 40 SSTSPGDYVLSVSENSRVSHYIINS 64
S T GDY LS N +V H I+S
Sbjct: 588 SETFVGDYTLSFWRNGKVQHCRIHS 612
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 63.2 bits (152), Expect = 2e-10
Identities = 49/207 (23%), Positives = 81/207 (39%), Gaps = 42/207 (20%)
Query: 6 DSEERSSWYWGRLSRQEAV-ALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS 64
++ E WY L+R +A L++ R G FLVR + P Y +S ++ H +
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGKIKHCRVQQ 719
Query: 65 SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY---------KIHYLDTTTLI 115
G + +G+ EFDSL L+ +Y K+ Y +
Sbjct: 720 EG------------------QTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEAL 761
Query: 116 EPVSRSRQGSGVILRQEEAEY-------------VRALFDFNGNDEEDLPFKKGDILRIR 162
E + + G + + V+ALFD+ E++L F K I++
Sbjct: 762 EKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNV 821
Query: 163 DKPEEQWWNAEDSEGKRGMIPVPYVEK 189
+K E WW + K+ P YVE+
Sbjct: 822 EKQEGGWWRGDYGGKKQLWFPSNYVEE 848
Score = 36.2 bits (82), Expect = 0.020
Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 23/85 (27%)
Query: 3 GNFDSEE------------RSSWYWGRLS-----RQEAVALLQ------GQRHGVFLVRD 39
GN D EE W+ G+L R A LL G G FLVR+
Sbjct: 528 GNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRE 587
Query: 40 SSTSPGDYVLSVSENSRVSHYIINS 64
S T GDY LS N +V H I+S
Sbjct: 588 SETFVGDYTLSFWRNGKVQHCRIHS 612
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 61.6 bits (148), Expect = 4e-10
Identities = 54/192 (28%), Positives = 80/192 (41%), Gaps = 38/192 (19%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
WY G + R A ++L + G FLVR ++ +S+ N V H I ++
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTA------- 723
Query: 73 PSPAQPPPGVSPSRLRIGDQE-FDSLPALLEFYK-------IHYLDTTTLI---EP---- 117
RI +++ F L L+EFY+ LDTT EP
Sbjct: 724 -----------EGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRT 772
Query: 118 VSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEG 177
+SR GS +A Y DF D +L K+GDI++I +K +Q W + G
Sbjct: 773 ISRPAVGSTKYFGTAKARY-----DFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYG 827
Query: 178 KRGMIPVPYVEK 189
+ G P YVE+
Sbjct: 828 RVGWFPANYVEE 839
>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
Length = 614
Score = 53.9 bits (128), Expect = 9e-08
Identities = 24/56 (42%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 94 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 148
>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
Length = 677
Score = 53.9 bits (128), Expect = 9e-08
Identities = 24/56 (42%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210
>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
Length = 732
Score = 53.9 bits (128), Expect = 9e-08
Identities = 24/56 (42%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210
>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
Length = 733
Score = 53.9 bits (128), Expect = 9e-08
Identities = 24/56 (42%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190
EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 53.5 bits (127), Expect = 1e-07
Identities = 26/48 (54%), Positives = 32/48 (66%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
W+ G++S QEAV LQ G+FLVR+S+ PGDYVL VS V HY
Sbjct: 81 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 128
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 53.5 bits (127), Expect = 1e-07
Identities = 26/48 (54%), Positives = 32/48 (66%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
W+ G++S QEAV LQ G+FLVR+S+ PGDYVL VS V HY
Sbjct: 123 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 170
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 53.5 bits (127), Expect = 1e-07
Identities = 26/48 (54%), Positives = 32/48 (66%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
W+ G++S QEAV LQ G+FLVR+S+ PGDYVL VS V HY
Sbjct: 122 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 169
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 53.1 bits (126), Expect = 2e-07
Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 64 SSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQ 123
S G PP P P Q +P+ G S P F T + ++ SR
Sbjct: 130 SPGGSPPARPIPGQ---SAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRT 186
Query: 124 GSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIP 183
Y +AL+ + G + DL F KGDI+ +R K +EQW++ E G +G +P
Sbjct: 187 APAA-KNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGE-LHGTQGFLP 244
Query: 184 VPYVEKYRP 192
Y++ +P
Sbjct: 245 ASYIQCIQP 253
Score = 33.5 bits (75), Expect = 0.13
Identities = 15/57 (26%), Positives = 28/57 (49%), Gaps = 1/57 (1%)
Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAE-DSEGKRGMIPVPYVEKY 190
E R + + E ++ K+GDI+ + K E+ W+ G+ G+ P +VE +
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF 882
Score = 28.1 bits (61), Expect = 5.4
Identities = 14/50 (28%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWW-NAEDSEGKRGMIPVPYV 187
AL+ + ++L KG++ R+ +K ++ W+ A G G+ P YV
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 52.4 bits (124), Expect = 3e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Score = 30.4 bits (67), Expect = 1.1
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ + W+ S+ +G +P Y+
Sbjct: 99 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 147
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 52.4 bits (124), Expect = 3e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 166 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
Score = 30.4 bits (67), Expect = 1.1
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ + W+ S+ +G +P Y+
Sbjct: 114 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 162
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 52.4 bits (124), Expect = 3e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 145 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204
Score = 30.4 bits (67), Expect = 1.1
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ + W+ S+ +G +P Y+
Sbjct: 93 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 141
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 52.4 bits (124), Expect = 3e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Score = 30.4 bits (67), Expect = 1.1
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ + W+ S+ +G +P Y+
Sbjct: 99 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 147
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 52.4 bits (124), Expect = 3e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 130 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189
Score = 30.4 bits (67), Expect = 1.1
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ + W+ S+ +G +P Y+
Sbjct: 78 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 126
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 52.0 bits (123), Expect = 3e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 120 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179
Score = 28.1 bits (61), Expect = 5.4
Identities = 13/49 (26%), Positives = 23/49 (46%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ W ++ +G +P Y+
Sbjct: 68 ALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYI 116
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 52.0 bits (123), Expect = 3e-07
Identities = 27/60 (45%), Positives = 37/60 (61%)
Query: 6 DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
+S E+ SWY G +SR A LL +G FLVR+S +SPG +S+ RV HY IN++
Sbjct: 139 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 198
Score = 28.1 bits (61), Expect = 5.4
Identities = 13/49 (26%), Positives = 23/49 (46%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
AL+DF + + L KG+ LR+ W ++ +G +P Y+
Sbjct: 87 ALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYI 135
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 51.6 bits (122), Expect = 5e-07
Identities = 23/50 (46%), Positives = 34/50 (68%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYII 62
W+ G+++R++A LL G+FLVR+S+ PGDY L VS + +V HY I
Sbjct: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRI 131
Score = 48.1 bits (113), Expect = 5e-06
Identities = 22/52 (42%), Positives = 34/52 (65%), Gaps = 1/52 (1%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRI-RDKPEEQWWNAEDSEGKRGMIPVPYVEK 189
A ++F+G E+DLPF KGD+L I + W+ A++ G+ G+IP YV+K
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 51.6 bits (122), Expect = 5e-07
Identities = 23/50 (46%), Positives = 34/50 (68%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYII 62
W+ G+++R++A LL G+FLVR+S+ PGDY L VS + +V HY I
Sbjct: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRI 131
Score = 48.1 bits (113), Expect = 5e-06
Identities = 22/52 (42%), Positives = 34/52 (65%), Gaps = 1/52 (1%)
Query: 139 ALFDFNGNDEEDLPFKKGDILRI-RDKPEEQWWNAEDSEGKRGMIPVPYVEK 189
A ++F+G E+DLPF KGD+L I + W+ A++ G+ G+IP YV+K
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 51.6 bits (122), Expect = 5e-07
Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 20/97 (20%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
W+ G+LSR+EA ALLQ +G FLVR+S+T+PG YVL+ ++ + H ++
Sbjct: 378 WFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL---------- 425
Query: 73 PSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYL 109
P GV +R D F+S+ L+ ++ ++L
Sbjct: 426 ----VDPEGV----VRTKDHRFESVSHLISYHMDNHL 454
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 51.6 bits (122), Expect = 5e-07
Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 20/97 (20%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
W+ G+LSR+EA ALLQ +G FLVR+S+T+PG YVL+ ++ + H ++
Sbjct: 489 WFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL---------- 536
Query: 73 PSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYL 109
P GV +R D F+S+ L+ ++ ++L
Sbjct: 537 ----VDPEGV----VRTKDHRFESVSHLISYHMDNHL 565
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 51.6 bits (122), Expect = 5e-07
Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 20/97 (20%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
W+ G+LSR+EA ALLQ +G FLVR+S+T+PG YVL+ ++ + H ++
Sbjct: 488 WFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL---------- 535
Query: 73 PSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYL 109
P GV +R D F+S+ L+ ++ ++L
Sbjct: 536 ----VDPEGV----VRTKDHRFESVSHLISYHMDNHL 564
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 51.6 bits (122), Expect = 5e-07
Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 20/97 (20%)
Query: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
W+ G+LSR+EA ALLQ +G FLVR+S+T+PG YVL+ ++ + H ++
Sbjct: 379 WFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL---------- 426
Query: 73 PSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYL 109
P GV +R D F+S+ L+ ++ ++L
Sbjct: 427 ----VDPEGV----VRTKDHRFESVSHLISYHMDNHL 455
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 51.6 bits (122), Expect = 5e-07
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 35/179 (19%)
Query: 12 SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
+WY GR+ RQ + L+Q R G FLVRDS +SPG++VL+ + H+ IN + R
Sbjct: 153 AWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210
Query: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSR------ 120
S Q + + FDS+P L+ Y I + +P++R
Sbjct: 211 AYSRVQ---------YQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRC 261
Query: 121 -----------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ 168
+R+GS R + A+ + E++LP +G++LR ++K Q
Sbjct: 262 LEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP--RGNLLRNKEKSGSQ 318
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.135 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,606,511
Number of Sequences: 37866
Number of extensions: 548227
Number of successful extensions: 7729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 427
Number of HSP's successfully gapped in prelim test: 180
Number of HSP's that attempted gapping in prelim test: 5371
Number of HSP's gapped (non-prelim): 2127
length of query: 204
length of database: 18,247,518
effective HSP length: 97
effective length of query: 107
effective length of database: 14,574,516
effective search space: 1559473212
effective search space used: 1559473212
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.