Search of human proteins with 40805836

Search of human proteins with 40805836

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide
6 isoform 1 [Homo sapiens]
         (497 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...  1009   0.0  
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   880   0.0  
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   376   e-104
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   357   1e-98
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   350   2e-96
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   347   2e-95
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   343   2e-94
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   343   3e-94
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   342   4e-94
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   340   2e-93
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   330   2e-90
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   329   3e-90
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   327   1e-89
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   323   3e-88
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   309   3e-84
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   304   1e-82
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   302   5e-82
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   268   1e-71
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   243   2e-64
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   242   7e-64
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   230   2e-60
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   201   1e-51
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  190   2e-48
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   180   2e-45
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   154   1e-37
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   104   2e-22
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   100   4e-21
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...    97   3e-20
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    96   6e-20
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...    93   5e-19

>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score = 1009 bits (2608), Expect = 0.0
 Identities = 497/497 (100%), Positives = 497/497 (100%)

Query: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
           MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
Sbjct: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

Query: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
           LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
Sbjct: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
           LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

Query: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240
           AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240

Query: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA 300
           LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA
Sbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA 300

Query: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360
           DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
Sbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360

Query: 361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420
           HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
Sbjct: 361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420

Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480
           LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
Sbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480

Query: 481 FAFLVTPSPYELCAVPR 497
           FAFLVTPSPYELCAVPR
Sbjct: 481 FAFLVTPSPYELCAVPR 497


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  880 bits (2275), Expect = 0.0
 Identities = 446/497 (89%), Positives = 446/497 (89%), Gaps = 51/497 (10%)

Query: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
           MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
Sbjct: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

Query: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
           LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ   
Sbjct: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ--- 117

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
                                                           GRPFRPNGLLDK
Sbjct: 118 ------------------------------------------------GRPFRPNGLLDK 129

Query: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240
           AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
Sbjct: 130 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 189

Query: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA 300
           LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA
Sbjct: 190 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA 249

Query: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360
           DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
Sbjct: 250 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 309

Query: 361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420
           HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
Sbjct: 310 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 369

Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480
           LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
Sbjct: 370 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 429

Query: 481 FAFLVTPSPYELCAVPR 497
           FAFLVTPSPYELCAVPR
Sbjct: 430 FAFLVTPSPYELCAVPR 446


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  376 bits (966), Expect = e-104
 Identities = 206/483 (42%), Positives = 295/483 (61%), Gaps = 10/483 (2%)

Query: 16  FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAW 75
           FLL  D + RR+     YPPGP  LP LGN   VDF+ +        +++G++FSL+L  
Sbjct: 28  FLLAADFLKRRR--PKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGD 85

Query: 76  TPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFS 135
              V++ GL  ++EAL+   ++  +RP  P+ + +    +  G+ ++  G AW+EQRRF+
Sbjct: 86  ISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF---KKNGLIMSS-GQAWKEQRRFT 141

Query: 136 VSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRF 195
           ++ LRN GLGKKSLE+ + EEA  L  A    +G+PF P+  ++ AVSN+I S+T G RF
Sbjct: 142 LTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERF 201

Query: 196 EYDDPRFLRLLDLAQEGLKEESGFLREVLNAVP-VLLHIPALAGKVLRFQKAFLTQLDEL 254
           EY D  F +LL L  E    E+    ++ N  P ++  +P     +    K     +  +
Sbjct: 202 EYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHM 261

Query: 255 LTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTL 314
           + +HR  W+PA+  RD  +A+L EM K  GNP SSF++ENL     DLF AG  TTSTTL
Sbjct: 262 IDKHRKDWNPAE-TRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320

Query: 315 AWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGV 374
            W LL M L+P++Q +VQ EID VIGQ ++P    +  MPYT AVIHEVQR G+I+PL V
Sbjct: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380

Query: 375 THMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL 434
               + D  + G+ +PKGT ++TNL+++ +D   W  P  F+P+HFL+  G F K EAF+
Sbjct: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFM 439

Query: 435 PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCA 494
           PFS G+RACLGE LAR ELF+FFTSL+Q F+F  P  + + S        ++P  + LCA
Sbjct: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNE-KLSLKFRMGITISPVSHRLCA 498

Query: 495 VPR 497
           VP+
Sbjct: 499 VPQ 501


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  357 bits (916), Expect = 1e-98
 Identities = 203/490 (41%), Positives = 289/490 (58%), Gaps = 12/490 (2%)

Query: 11  VIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFS 70
           V+   F+LL  L  +  R   + PPGP PLP +GN+L +D ++    F    + +G VF+
Sbjct: 8   VLCLSFMLLFSLWRQSCR-RRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFT 66

Query: 71  LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL--GFGPRSQGVFLARYGPAW 128
           +     P+VV +G  AV+EAL+ +GE+ + R   PI+Q +  G G       ++  G  W
Sbjct: 67  VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLG------IISSNGKRW 120

Query: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188
           +E RRFS++TLRN G+GK+S+E  V EEA CL          P  P  +L  A  NVI S
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAF 247
           +   +RF+Y D  FL L+    E  +  +    +V N  P+L+   P    KVL+     
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240

Query: 248 LTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGM 307
            + + E + EH+ + D    PRD  + FL +ME+ K N +S FN ENL   VADLF AG 
Sbjct: 241 RSYIREKVKEHQASLD-VNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGT 299

Query: 308 VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG 367
            TTSTTL +GLLL++ HP+V  +VQ+EID VIG+ R P M D++HMPYT AV+HE+QR+ 
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYS 359

Query: 368 DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF 427
           D+VP GV H  + D + + + IPKGTT++  L+SVL D+  +  P  F P HFLD  G+F
Sbjct: 360 DLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNF 419

Query: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVT- 486
            K + F+PFSAG+R C GE LARMELFLF T++LQ+F+          +   V   +V+ 
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479

Query: 487 PSPYELCAVP 496
           P  Y++C +P
Sbjct: 480 PPSYQICFIP 489


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  350 bits (897), Expect = 2e-96
 Identities = 206/519 (39%), Positives = 290/519 (55%), Gaps = 31/519 (5%)

Query: 1   MGLEALVPL--AVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHV--------- 49
           +GL  L P   A+++   + L+     R+R A   PPGP P P +GN  HV         
Sbjct: 25  LGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRR 84

Query: 50  --------------DFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHG 95
                                    L R +G +FS  +    VVVL+   +VREALV   
Sbjct: 85  SWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQA 144

Query: 96  EDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTE 155
           E  +DRP VP+  I+    + +GV  A YGP WR+QR+FS STLR+ GLGK SLE  + E
Sbjct: 145 EVFSDRPRVPLISIV---TKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIE 201

Query: 156 EAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE 215
           E   + A    H   PF P  ++  AVSN+I SL  G+RF+Y +  F ++L     GL+ 
Sbjct: 202 EFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEI 261

Query: 216 ESGFLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEA 274
                  ++N  P L ++P    K LR  +K   + L +++ +H+ + D  + P+D  + 
Sbjct: 262 CLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLD-RENPQDFIDM 320

Query: 275 FLAEMEKA-KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333
           +L  ME+  K N  SSF++E L  ++ DLF AG  TT+ +L W LL M L+PDVQ +V +
Sbjct: 321 YLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHE 380

Query: 334 EIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGT 393
           EI+ VIG  R P + D+A MPYT A I EVQR   +VPL + HMTS +  +QG+ IPKGT
Sbjct: 381 EIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGT 440

Query: 394 TLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMEL 453
            ++ NL SV +D A+WEKP  F+P  FLD QG  +K E F+PF  G+R C+GE LA+MEL
Sbjct: 441 LILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMEL 500

Query: 454 FLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYEL 492
           FL F SL+Q F+F++P    +P   G F   + P P+ +
Sbjct: 501 FLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNI 539


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  347 bits (889), Expect = 2e-95
 Identities = 194/490 (39%), Positives = 286/490 (58%), Gaps = 7/490 (1%)

Query: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68
           + +++ +  LL+  + R+     + PPGP PLP +GN+L +D ++       L + +G V
Sbjct: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128
           F+L      +VVL+G   V+EAL+  GE+ + R   P+ +      R  G+  +  G  W
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERAN---RGFGIVFSN-GKRW 120

Query: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188
           +E RRFS+ TLRN G+GK+S+E  V EEA CL          P  P  +L  A  NVI S
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAF 247
           +   +RF+Y D +FL L++   E ++  S    ++ N  P ++ + P    K+L+     
Sbjct: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240

Query: 248 LTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGM 307
            + + E + EH+ + D    PRD  + FL +MEK K N +S F  ENL I  ADL  AG 
Sbjct: 241 ESDILEKVKEHQESMD-INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299

Query: 308 VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG 367
            TTSTTL + LLL++ HP+V  +VQ+EI+ VIG+ R P M D+ HMPYT AV+HEVQR+ 
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359

Query: 368 DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF 427
           D++P  + H  + D++ + + IPKGTT++T+L+SVL D   +  P  F P HFLD  G+F
Sbjct: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419

Query: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVT 486
            K   F+PFSAG+R C+GE LARMELFLF T +LQ+F+  S+   +   +   V  F   
Sbjct: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASV 479

Query: 487 PSPYELCAVP 496
           P  Y+LC +P
Sbjct: 480 PPFYQLCFIP 489


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  343 bits (880), Expect = 2e-94
 Identities = 202/502 (40%), Positives = 284/502 (56%), Gaps = 16/502 (3%)

Query: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
           M L  L+ LA++  + LLLV    R      R PPGP PLP LGNLL +D +     F +
Sbjct: 1   MELSVLLFLALLTGLLLLLVQ---RHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57

Query: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
            R ++GDVF++ L   PVV+L G+ A+REALV   E  + R  + +        R  GV 
Sbjct: 58  FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFF---RGYGVI 114

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
            A  G  W+  RRFSV+T+R+ G+GK+S+E+ + EEA CL        G    P  L   
Sbjct: 115 FAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQS 173

Query: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGK 239
             +N+I S+  G+RF Y D  FL++L+L  +     S    ++       L + P    +
Sbjct: 174 ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQ 233

Query: 240 VLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVV 299
           V +  +     +   + +HR T DP+ P +DL + +L  MEK K N  S F+ +NL +  
Sbjct: 234 VYKNLQEINAYIGHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292

Query: 300 ADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAV 359
             LF AG  TTSTTL +G LLM+ +P V  RV +EI+ VIG  R PE+ D+A MPYT AV
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 360 IHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH 419
           I+E+QRF D++P+GV H+ ++    +G+ IPK T +   LS+ L D   +EKP  F+P+H
Sbjct: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412

Query: 420 FLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQP----RP 475
           FLDA G   K EAF+PFS G+R CLGE +AR ELFLFFT++LQ+FS + P         P
Sbjct: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472

Query: 476 SHHGVFAFLVTPSPYELCAVPR 497
              GV      P  Y++  +PR
Sbjct: 473 QECGVGKI---PPTYQIRFLPR 491


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  343 bits (879), Expect = 3e-94
 Identities = 197/496 (39%), Positives = 291/496 (58%), Gaps = 9/496 (1%)

Query: 3   LEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLR 62
           +++LV L + ++  LLL   + R+     + PPGP PLP +GN+L +  ++       L 
Sbjct: 1   MDSLVVLVLCLSCLLLLS--LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLS 58

Query: 63  RRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLA 122
           + +G VF+L     P+VVL+G  AV+EAL+  GE+ + R   P+ +      R  G+  +
Sbjct: 59  KVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFS 115

Query: 123 RYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAV 182
             G  W+E RRFS+ TLRN G+GK+S+E  V EEA CL          P  P  +L  A 
Sbjct: 116 N-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAP 174

Query: 183 SNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLLHIPALAGKVL 241
            NVI S+   +RF+Y D +FL L++   E +K   S +++   N  P++ + P    K+L
Sbjct: 175 CNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234

Query: 242 RFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVAD 301
           +      + + E + EH+ + D    P+D  + FL +MEK K N  S F  E+L     D
Sbjct: 235 KNVAFMKSYILEKVKEHQESMD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVD 293

Query: 302 LFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIH 361
           LF AG  TTSTTL + LLL++ HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+H
Sbjct: 294 LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVH 353

Query: 362 EVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421
           EVQR+ D++P  + H  + DI+ + + IPKGTT++ +L+SVL D   +  P  F P HFL
Sbjct: 354 EVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413

Query: 422 DAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGV 480
           D  G+F K + F+PFSAG+R C+GE LA MELFLF TS+LQ+F+  S+   +   +   V
Sbjct: 414 DEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVV 473

Query: 481 FAFLVTPSPYELCAVP 496
             F   P  Y+LC +P
Sbjct: 474 NGFASVPPFYQLCFIP 489


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  342 bits (878), Expect = 4e-94
 Identities = 192/493 (38%), Positives = 289/493 (58%), Gaps = 13/493 (2%)

Query: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68
           +A+++ +  L +  + R+     R P GP PLP +GN+L +D ++         + +G V
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128
           F++     P+VVL+G  AV+EAL+ HGE+ + R   P+ + +  G    G+  +  G  W
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKG---LGILFSN-GKRW 120

Query: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188
           +E RRF + TLRN G+GK+S+E  V EEA CL       +  P  P  +L  A  NVI S
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAF 247
           +    RF+Y D RFL L++   E L+  S    +V N  P L+ ++P    K+       
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 248 LTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGM 307
            + + E + EH+ + D     RD  + FL +ME+ K N +S F  E+L   V D+F AG 
Sbjct: 241 KSYVLERIKEHQESLD-MNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGT 299

Query: 308 VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG 367
            TTSTTL +GLLL++ +P+V  +VQ+EI+ V+G+ R P M D++HMPYT AV+HE+QR+ 
Sbjct: 300 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 359

Query: 368 DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF 427
           D++P  + H  + D++ + + IPKGTT+IT+L+SVL ++  +  P  F P HFLD  G+F
Sbjct: 360 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 419

Query: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVF----AF 483
            K + F+PFSAG+R C+GE LARMELFLF T++LQ+F+      Q  P    +     AF
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPKDIDITPIANAF 476

Query: 484 LVTPSPYELCAVP 496
              P  Y+LC +P
Sbjct: 477 GRVPPLYQLCFIP 489


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  340 bits (872), Expect = 2e-93
 Identities = 200/498 (40%), Positives = 287/498 (57%), Gaps = 18/498 (3%)

Query: 7   VPLAVIV-AIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
           V +A++V A FLLLV  M R+   +   PPGP PLP +GNL  ++ +N P  F +L +RF
Sbjct: 6   VTVALLVWAAFLLLVS-MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRF 64

Query: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125
           G VF+L +    +VV++G  AV+EAL+ + ++ + R  +P         R +G+     G
Sbjct: 65  GPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH----AHRDRGIIFNN-G 119

Query: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185
           P W++ RRFS++TLRN G+GK+  E  +  EA  L  A     G+PF P  L+  A  NV
Sbjct: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179

Query: 186 IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQ 244
           IA +   + F+Y+D +FLRL+ L  E     S    ++ N  P  LH +P    KV++  
Sbjct: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239

Query: 245 KAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFS 304
                 + E + EH  + DP   PRDLT+  L EMEK K + E  +  + + + VADLF 
Sbjct: 240 AEVKEYVSERVKEHHQSLDP-NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFF 298

Query: 305 AGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQ 364
           AG  TTSTTL +GLL+++ +P+++ ++ +EID VIG  R P + D+  MPY  AV+HE+Q
Sbjct: 299 AGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQ 358

Query: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQ 424
           RF  +VP  + H  +RD   +G+ IPKGT ++  L SVL D   +  P +F PEHFL+  
Sbjct: 359 RFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNEN 418

Query: 425 GHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHG 479
           G F   + F PFS G+R C GE LARMELFL   ++LQHF+   P   P+     P H G
Sbjct: 419 GKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK-PLVDPKDIDLSPIHIG 477

Query: 480 VFAFLVTPSPYELCAVPR 497
              F   P  Y+LC +PR
Sbjct: 478 ---FGCIPPRYKLCVIPR 492


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  330 bits (846), Expect = 2e-90
 Identities = 196/489 (40%), Positives = 274/489 (56%), Gaps = 9/489 (1%)

Query: 14  AIFLLLVDLMHR---RQRWAARYPPGPLPLPGLGNLLHVDFQNT-PYCFDQLRRR-FGDV 68
           A+FLLL  L  R   +QR    +PPGP  LP +GN+  +   +  P+ + + + + +G++
Sbjct: 17  ALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76

Query: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128
           FSL L     VVLNG   V+E LV   E  ADRP +P+   +    +  G+  +RYG  W
Sbjct: 77  FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM---TKMGGLLNSRYGRGW 133

Query: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188
            + RR +V++ R  G G+KS E  + EE      A   + GRPF    L+  AVSN+   
Sbjct: 134 VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193

Query: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFL 248
           +  G RF Y+D  F  +++L  E ++  +     + NA P +  +P    + L    A +
Sbjct: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253

Query: 249 TQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMV 308
                 L E        Q P+   +A+L EM++ K +P S+F+ ENL   V +L  AG  
Sbjct: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313

Query: 309 TTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGD 368
           TT+  L W +L M L+P++Q +VQ+EID ++G   +P   D+  MPYT AV+HEV RF +
Sbjct: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373

Query: 369 IVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFV 428
           IVPLG+ H TS D  V+G+ IPKGTT+ITNL SV  DE  W  P  FHPE FLD+ G+F 
Sbjct: 374 IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA 433

Query: 429 KPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPS 488
           K EA +PFS GRR CLGE LARME+FLFFT+LLQ F    P  +  P         + P 
Sbjct: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP-HELVPDLKPRLGMTLQPQ 492

Query: 489 PYELCAVPR 497
           PY +CA  R
Sbjct: 493 PYLICAERR 501


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  329 bits (844), Expect = 3e-90
 Identities = 195/497 (39%), Positives = 284/497 (57%), Gaps = 15/497 (3%)

Query: 7   VPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG 66
           +  A+++ +  L+  L+    R   + PPGP PL  LGNLL +  Q+      +L + +G
Sbjct: 4   ISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63

Query: 67  DVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGP 126
            ++++ L    VVVL+G  AV+EALV  GE+ + R   P      F  +  G+  +  G 
Sbjct: 64  SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPA--FFNF-TKGNGIAFSS-GD 119

Query: 127 AWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVI 186
            W+  R+FS+  LRN G+GK+S+E+ + EE + L A      G PF P  +L ++VSN+I
Sbjct: 120 RWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNII 179

Query: 187 ASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQK 245
            S+  G RF+YDD R L ++ L  +  +  S    E+ +  P LL  +P    ++ +  K
Sbjct: 180 CSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFK 239

Query: 246 AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSA 305
                +   + +H+ + DP + PRD  + FL +M + K +P S F+ + L +   +L   
Sbjct: 240 CLRDLIAHSVHDHQASLDP-RSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFG 298

Query: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR 365
           G  T STTL    L ++ +P VQ RVQ+EID V+G+ R P + D+A MPYT AVIHEVQR
Sbjct: 299 GTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQR 358

Query: 366 FGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 425
           F DI+P+ + H  +RD   +GF IPKGT +IT L++V  D + +  P  F+PEHFLDA  
Sbjct: 359 FADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQ 418

Query: 426 HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGV 480
            F K  AF+PFSAGRR CLGE LARMELFL+ T++LQ FS   P G P      P   G+
Sbjct: 419 SFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQ-PLGAPEDIDLTPLSSGL 477

Query: 481 FAFLVTPSPYELCAVPR 497
                 P P++LC  PR
Sbjct: 478 GNL---PRPFQLCLRPR 491


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  327 bits (839), Expect = 1e-89
 Identities = 200/470 (42%), Positives = 262/470 (55%), Gaps = 10/470 (2%)

Query: 30  AARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVRE 89
           AAR+PPGP PLP +GNL  +          +L  R+G VF++ L     VVL G  AV+E
Sbjct: 28  AARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKE 87

Query: 90  ALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSL 149
           AL   G++ ADRPP+ I Q++    R  G+F +  G  WR  R+F+V  L +LG+G++ +
Sbjct: 88  ALAGPGQELADRPPIAIFQLI---QRGGGIFFSS-GARWRAARQFTVRALHSLGVGREPV 143

Query: 150 EQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLA 209
              + +E  CL      + GRPF P  LL  A SN+  +L  GRRF+Y DP F+ LL L 
Sbjct: 144 ADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLI 202

Query: 210 QEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPR 269
            E +        ++ N  P L  +  L   VLR  +     L  LL   R    P  P  
Sbjct: 203 DEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVC 262

Query: 270 DLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR 329
              +A + + +    +PE  F + N      D+  AG  TTS TL W  LLM  HPDVQ 
Sbjct: 263 SYVDALIQQGQG--DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQG 320

Query: 330 RVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRI 389
           RVQ+E+D V+G  R P + DQ  +PYT+AV+HEVQRF  ++P  V   T+ D ++ GF +
Sbjct: 321 RVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLL 379

Query: 390 PKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449
           PKGT +I  L+SVL DE  W+ P +F+P HFLDA GHFVK EAFLPFSAGRR C+GE LA
Sbjct: 380 PKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLA 439

Query: 450 RMELFLFFTSLLQHFSFSVPTGQPRPS--HHGVFAFLVTPSPYELCAVPR 497
           R ELFL F  LLQ +    P G    S       AF + P    LCAVPR
Sbjct: 440 RTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPR 489


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  323 bits (827), Expect = 3e-88
 Identities = 190/499 (38%), Positives = 284/499 (56%), Gaps = 19/499 (3%)

Query: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
           LV L   + + +L+     R+ R   + PPGP PLP +GN L ++ +       ++  R+
Sbjct: 8   LVTLLACLTVMVLMSVWRQRKSR--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65

Query: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125
           G VF++ L    VVVL G  AV+EALV   E+ + R        L  G    GV  +  G
Sbjct: 66  GPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKG---YGVAFSN-G 121

Query: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185
              ++ RRFS++TLR  G+GK+ +E+ + EEA  L  A     G    P   L + VSNV
Sbjct: 122 ERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNV 181

Query: 186 IASLTCGRRFEYDDPRFLRLLDLAQEGLK---EESGFLREVLNAVPVLLHIPALAGKVLR 242
           I+S+  G RF+Y+D  FL LL +     +     +G L E+ ++  V+ H+P    +  +
Sbjct: 182 ISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSS--VMKHLPGPQQQAFK 239

Query: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302
             +     + + +  ++ T DP   PRD  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 240 ELQGLEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNL 298

Query: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362
           F AG  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+A MPYT AVIHE
Sbjct: 299 FFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHE 358

Query: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422
           +QRFGD++P+G+ H  ++D + + F +PKGT +   L SVL+D   +  P  F+P+HFLD
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418

Query: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHH 478
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F F  P         P H 
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHV 478

Query: 479 GVFAFLVTPSPYELCAVPR 497
           G   F   P  Y +  +PR
Sbjct: 479 G---FATIPRNYTMSFLPR 494


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  309 bits (792), Expect = 3e-84
 Identities = 185/499 (37%), Positives = 281/499 (56%), Gaps = 19/499 (3%)

Query: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
           LV L V + + +L+     R+ +   + PPGP PLP +GN L ++ +       ++  R+
Sbjct: 8   LVALLVCLTVMVLMSVWQQRKSK--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65

Query: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125
           G VF++ L    VVVL G  AVREALV   E+ + R        +  G    GV  +  G
Sbjct: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKG---YGVVFSN-G 121

Query: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185
              ++ RRFS++TLR+ G+GK+ +E+ + EEA  L  A     G    P   L + VSNV
Sbjct: 122 ERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNV 181

Query: 186 IASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLR 242
           I+S+  G RF+Y D  FL LL +     +     +G L E+ ++V  + H+P    +  +
Sbjct: 182 ISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSV--MKHLPGPQQQAFQ 239

Query: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302
             +     + + +  ++ T DP   PRD  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 240 LLQGLEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNL 298

Query: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362
           F  G  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE
Sbjct: 299 FIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHE 358

Query: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422
           +QRFGD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF----SFSVPTGQPRPSHH 478
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F    S S       P H 
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV 478

Query: 479 GVFAFLVTPSPYELCAVPR 497
           G   F   P  Y +  +PR
Sbjct: 479 G---FATIPRNYTMSFLPR 494


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  304 bits (778), Expect = 1e-82
 Identities = 189/503 (37%), Positives = 282/503 (56%), Gaps = 19/503 (3%)

Query: 3   LEALVPLAVIVAI-FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL 61
           +EA    A+++A+  LLL+ L     R     PPGP PLP LGNLL +          +L
Sbjct: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

Query: 62  RRRFGDVFSLQLA-WTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
            +++G VF++ L  W PVVVL G  AVREAL    E+ + R  V + +    G    GVF
Sbjct: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDG---HGVF 117

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
            +  G  WR+ R+F++  LR+LG+GK+  E+ +  EA CL   F    GRPF P+ LL +
Sbjct: 118 FSN-GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQ 176

Query: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQE---GLKEESGFLREVLNAVPVLLHIPALA 237
           A SNV+ SL  G RF Y+D  F  ++  A     G+  + G   E+ +    L  +P   
Sbjct: 177 ATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPH 234

Query: 238 GKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCI 297
            ++L             + +H+   D + P RDL +AFL +M + + NP + F ++N+ +
Sbjct: 235 KQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLM 294

Query: 298 VVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTT 357
            V  L  AG +T STT+ + LLL++ +P VQ+ V++E++  +G  + P +GD+  +PYT 
Sbjct: 295 TVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTD 354

Query: 358 AVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHP 417
           AV+HE QR   +VP+G+     R    +G+ +P+GT +   L S+L D  +++ P  F+P
Sbjct: 355 AVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNP 414

Query: 418 EHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP----TGQP 473
           + FLDA G F K EAFLPFS G+R CLGE LA+ ELFLFFT++LQ FS   P    T   
Sbjct: 415 DRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSL 474

Query: 474 RPSHHGVF----AFLVTPSPYEL 492
           +P+  G+F    AF +   P +L
Sbjct: 475 KPTVSGLFNIPPAFQLQVRPTDL 497


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  302 bits (773), Expect = 5e-82
 Identities = 180/498 (36%), Positives = 281/498 (56%), Gaps = 17/498 (3%)

Query: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
           LV L   + + +L+     R+ R   + PPGP PLP +GN L ++ ++      +    +
Sbjct: 8   LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECY 65

Query: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125
           G VF++ L    VVVL G  AVREALV   E+ + R          +  +  GV  +  G
Sbjct: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGE---QATFDWVFKGYGVAFSN-G 121

Query: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185
              ++  RF+++TLR+ G+GK+ +E+ + EE+  L  A  +  G    P   L + VSNV
Sbjct: 122 ERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNV 181

Query: 186 IASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLR 242
           I+S+  G RF+Y+D  FL LL +     +     +G L E+ ++  V+ H+P    +  +
Sbjct: 182 ISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSS--VMKHLPGPQQQAFK 239

Query: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302
             +     + + +  ++ T DP   P+D  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 240 LLQGLEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNL 298

Query: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362
           F AG  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+  MPY  AVIHE
Sbjct: 299 FIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHE 358

Query: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422
           +QRFGD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFLD
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418

Query: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---SFSVPTGQPRPSHHG 479
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F   S   P        H 
Sbjct: 419 DKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV 478

Query: 480 VFAFLVTPSPYELCAVPR 497
           VFA +  P  Y +  +PR
Sbjct: 479 VFATI--PRNYTMSFLPR 494


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  268 bits (684), Expect = 1e-71
 Identities = 167/498 (33%), Positives = 262/498 (52%), Gaps = 68/498 (13%)

Query: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
           LV L   + + +L+     R+ R   + PPGP PLP +GN L +   NT +  D + +  
Sbjct: 8   LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQL---NTEHICDSIMK-- 60

Query: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125
                         V  G+A       ++GE                             
Sbjct: 61  --------------VSQGVA------FSNGERA--------------------------- 73

Query: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185
              ++  RF+++TLR+ G+GK+ +E+ + EE+  L  A  +  G    P   L + VSNV
Sbjct: 74  ---KQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNV 130

Query: 186 IASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLR 242
           I+S+  G RF+Y+D  FL LL +     +     +G L E+ ++  V+ H+P    +  +
Sbjct: 131 ISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSS--VMKHLPGPQQQAFK 188

Query: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302
             +     + + +  ++ T DP   P+D  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 189 LLQGLEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNL 247

Query: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362
           F AG  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+  MPY  AVIHE
Sbjct: 248 FIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHE 307

Query: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422
           +QRFGD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFLD
Sbjct: 308 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 367

Query: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---SFSVPTGQPRPSHHG 479
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F   S   P        H 
Sbjct: 368 DKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV 427

Query: 480 VFAFLVTPSPYELCAVPR 497
           VFA +  P  Y +  +PR
Sbjct: 428 VFATI--PRNYTMSFLPR 443


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  243 bits (621), Expect = 2e-64
 Identities = 171/495 (34%), Positives = 241/495 (48%), Gaps = 34/495 (6%)

Query: 6   LVPLAVIVAIFLLLVD----------LMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTP 55
           L PL++     LLL+           L+ +R+R     PPGP   P +GN   V  Q   
Sbjct: 13  LNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAH 71

Query: 56  YCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR 115
             F +L RR+GDVF ++L   P+VVLNG  A+ +ALV  G   ADRP     +++  G  
Sbjct: 72  LSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGG-- 129

Query: 116 SQGVFLARYGPAWREQRRFSVSTLRNLGL----GKKSLEQWVTEEAACLCAAFANHS--G 169
            + +    Y   W+ QRR + S +RN        ++ LE  V  EA  L A     S  G
Sbjct: 130 -RSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADG 188

Query: 170 RPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVP 228
               P  L   AV+NV++++  G R+ +DDP F  LL   +E G    +G L +V+   P
Sbjct: 189 AFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVM---P 245

Query: 229 VLLHIPALAGKVLR----FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK-AK 283
            L + P     V R      + F   + +    H  +  P   PRD+ +AF+   EK A 
Sbjct: 246 WLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAA 305

Query: 284 GNPESS---FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIG 340
           G+        + EN+   + D+F A   T ST L W LLL   +PDVQ RVQ E+D V+G
Sbjct: 306 GDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVG 365

Query: 341 QVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLS 400
           + R P MGDQ ++PY  A ++E  RF   VP+ + H T+ +  V G+ IPK T +  N  
Sbjct: 366 RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQW 425

Query: 401 SVLKDEAVWEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFT 458
           SV  D   W  P  F P  FLD  G   K      + FS G+R C+GE L++M+LFLF +
Sbjct: 426 SVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFIS 485

Query: 459 SLLQHFSFSVPTGQP 473
            L     F     +P
Sbjct: 486 ILAHQCDFRANPNEP 500


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  242 bits (617), Expect = 7e-64
 Identities = 145/453 (32%), Positives = 241/453 (53%), Gaps = 22/453 (4%)

Query: 34  PPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT 93
           PPGP   P +G++L +  +N      ++ +++GDV  +++  TPVVVL+GL  +R+ALV 
Sbjct: 40  PPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98

Query: 94  HGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKS----- 148
            G+D   RP +    ++  G      F    GP W  +RR + + L++  +         
Sbjct: 99  QGDDFKGRPDLYTFTLISNGQSMS--FSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156

Query: 149 --LEQWVTEEAACLCAAFANHSGRP--FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLR 204
             LE+ V++EA  L +        P  F P   +  +V+NVI ++  GRR++++    L 
Sbjct: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216

Query: 205 LLDLAQE-GLKEESGFLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTW 262
           L++L    G    SG      + +P+L ++P  +    +   + F + + +++ EH  T+
Sbjct: 217 LVNLNNNFGEVVGSG---NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273

Query: 263 DPAQPPRDLTEAFLAEMEKAK--GNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320
           +     RD+T++ +   ++ +   N     +DE +  +V DLF AG  T +T ++W L+ 
Sbjct: 274 EKGHI-RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332

Query: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380
           ++++P VQR++Q+E+D VIG+ RRP + D++H+PY  A I E  R    VP  + H T+R
Sbjct: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392

Query: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF--VKPEAFLPFSA 438
           D  ++GF IPKG  +  N   +  D+ +W  P  F PE FL   G    V  E  + F  
Sbjct: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452

Query: 439 GRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471
           G+R C+GE +AR E+FLF   LLQ   FSVP G
Sbjct: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 485


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  230 bits (587), Expect = 2e-60
 Identities = 152/481 (31%), Positives = 239/481 (49%), Gaps = 20/481 (4%)

Query: 4   EALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRR 63
           E L+  A+   +F +L  L  R  +   + PP P   P LG++L +  +N      ++ +
Sbjct: 13  ELLLASAIFCLVFWVLKGLRPRVPK-GLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQ 70

Query: 64  RFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLAR 123
           R+GDV  +++  TPV+VL+ L  +R+ALV  G+D   RP +  + ++  G      F   
Sbjct: 71  RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL--TFSTD 128

Query: 124 YGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--FRP 174
            GP W  +RR + + L    +           LE+ V++EA  L +        P  F P
Sbjct: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188

Query: 175 NGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIP 234
              +  +V+NVI ++  G+ F       L L+    E ++  S      L+  P+L ++P
Sbjct: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFPILRYLP 246

Query: 235 ALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 293
             A +  + F + FL  L + + EH   +D     RD+T A     +K      +    E
Sbjct: 247 NPALQRFKAFNQRFLWFLQKTVQEHYQDFDK-NSVRDITGALFKHSKKGPRASGNLIPQE 305

Query: 294 NLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 353
            +  +V D+F AG  T +T ++W L+ ++  P++QR++Q+E+D VIG+ RRP + D+  +
Sbjct: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365

Query: 354 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 413
           PY  A I E  R    +P  + H T+RD  + GF IPK   +  N   V  D  +WE P 
Sbjct: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425

Query: 414 RFHPEHFLDAQGHFV-KP--EAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPT 470
            F PE FL A G  + KP  E  + F  G+R C+GE LA+ E+FLF   LLQ   FSVP 
Sbjct: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485

Query: 471 G 471
           G
Sbjct: 486 G 486


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  201 bits (511), Expect = 1e-51
 Identities = 102/218 (46%), Positives = 146/218 (66%), Gaps = 7/218 (3%)

Query: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
           K N +S F  E+L   V D+F AG  TTSTTL +GLLL++ +P+V  +VQ+EI+ V+G+ 
Sbjct: 216 KHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRN 275

Query: 343 RRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSV 402
           R P M D++HMPYT AV+HE+QR+ D++P  + H  + D++ + + IPKGTT+IT+L+SV
Sbjct: 276 RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSV 335

Query: 403 LKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQ 462
           L ++  +  P  F P HFLD  G+F K + F+PFSAG+R C+GE LARMELFLF T++LQ
Sbjct: 336 LHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQ 395

Query: 463 HFSFSVPTGQPRPSHHGVF----AFLVTPSPYELCAVP 496
           +F+      Q  P    +     AF   P  Y+LC +P
Sbjct: 396 NFNLK---SQVDPKDIDITPIANAFGRVPPLYQLCFIP 430



 Score =  132 bits (331), Expect = 9e-31
 Identities = 73/206 (35%), Positives = 113/206 (54%), Gaps = 4/206 (1%)

Query: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68
           +A+++ +  L +  + R+     R P GP PLP +GN+L +D ++         + +G V
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128
           F++     P+VVL+G  AV+EAL+ HGE+ + R   P+ + +  G    G+  +  G  W
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKG---LGILFSN-GKRW 120

Query: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188
           +E RRF + TLRN G+GK+S+E  V EEA CL       +  P  P  +L  A  NVI S
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 189 LTCGRRFEYDDPRFLRLLDLAQEGLK 214
           +    RF+Y D RFL L++   E L+
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLR 206


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  190 bits (483), Expect = 2e-48
 Identities = 134/483 (27%), Positives = 237/483 (49%), Gaps = 21/483 (4%)

Query: 12  IVAIFLLLVDLMH--RRQRWAARYPPGPLPLPGLGNL----LHVDFQNTPYCFDQLRRRF 65
           +VA+ LL +  +   +R+   A+YP   L LP +G+L     H    N    F +L++++
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNN---FFKLQKKY 60

Query: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125
           G ++S+++     V++      +E L+  G+D + RP +    I       +G+  A  G
Sbjct: 61  GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS--NNRKGIAFADSG 118

Query: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185
             W+  RR +++T      G + LE+ + +E + LC   A H+G+    +  +  AV+NV
Sbjct: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178

Query: 186 IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQK 245
           I+ +     ++  DP  L ++    EG+ +       +++ VP L   P    + L+   
Sbjct: 179 ISLICFNTSYKNGDPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHV 236

Query: 246 AFLTQL-DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FNDENLCIVV 299
                L +++L  ++  +        L     A+M    GN  P+      +D ++   +
Sbjct: 237 KIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTI 296

Query: 300 ADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAV 359
            D+F AG+ TT++ + W L  ++ +P V++++ +EID  +G  R P + D+  +    A 
Sbjct: 297 GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356

Query: 360 IHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH 419
           I EV R   + P+ + H  + D  +  F + KGT +I NL ++  +E  W +P +F PE 
Sbjct: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416

Query: 420 FLDAQG-HFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH 477
           FL+  G   + P  ++LPF AG R+C+GE LAR ELFL    LLQ F   VP     PS 
Sbjct: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476

Query: 478 HGV 480
            G+
Sbjct: 477 EGI 479


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  180 bits (457), Expect = 2e-45
 Identities = 143/462 (30%), Positives = 217/462 (46%), Gaps = 37/462 (8%)

Query: 29  WAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVR 88
           W  R    P   PG  +LL  D    P     L ++FG ++ L L    VVVLN    + 
Sbjct: 23  WKLRSLHLPPLAPGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIE 79

Query: 89  EALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKS 148
           EA+V    D A RP  P+T  L        + L  Y   W+  ++ + S L  LG+ + S
Sbjct: 80  EAMVKKWADFAGRPE-PLTYKL-VSRNYPDLSLGDYSLLWKAHKKLTRSALL-LGI-RDS 135

Query: 149 LEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD--PRFLRLL 206
           +E  V +     C       G P            ++I  LT G + + D+  P + + +
Sbjct: 136 MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCI 195

Query: 207 DLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDEL----LTEHRMTW 262
              QE LK  S +  ++++ +P L   P      LR  K  + + D +    L +H+ + 
Sbjct: 196 ---QEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRRLKQAIEKRDHIVEMQLRQHKESL 249

Query: 263 DPAQPPRDLTEAFLA-----EMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWG 317
              Q  RD+ +  L       ME+  G       + ++ +   DL   G  TT+ TL+W 
Sbjct: 250 VAGQW-RDMMDYMLQGVAQPSMEEGSGQ----LLEGHVHMAAVDLLIGGTETTANTLSWA 304

Query: 318 LLLMILHPDVQRRVQQEIDDVIG---QVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGV 374
           ++ ++ HP++Q+R+Q+E+D  +G      R    D+A +P   A I EV R   +VPL +
Sbjct: 305 VVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLAL 364

Query: 375 THMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL 434
            H T+R   + G+ IP+GT +I NL     DE VWE+P  F P+ FL+      K    L
Sbjct: 365 PHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRAL 420

Query: 435 PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS 476
            F  G R CLGEPLAR+ELF+  T LLQ F+  +P+G   PS
Sbjct: 421 AFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPS 461


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  154 bits (390), Expect = 1e-37
 Identities = 114/370 (30%), Positives = 179/370 (48%), Gaps = 32/370 (8%)

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
           L  Y   W+  ++ + S L  LG+ + S+E  V +     C       G P         
Sbjct: 80  LGDYSLLWKAHKKLTRSALL-LGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSL 137

Query: 181 AVSNVIASLTCGRRFEYDD--PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAG 238
              ++I  LT G + + D+  P + + +   QE LK  S +  ++++ +P L   P    
Sbjct: 138 LTCSIICYLTFGDKIKDDNLMPAYYKCI---QEVLKTWSHWSIQIVDVIPFLRFFP---N 191

Query: 239 KVLRFQKAFLTQLDEL----LTEHRMTWDPAQPPRDLTEAFLA-----EMEKAKGNPESS 289
             LR  K  + + D +    L +H+ +    Q  RD+ +  L       ME+  G     
Sbjct: 192 PGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGSGQ---- 246

Query: 290 FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIG---QVRRPE 346
             + ++ +   DL   G  TT+ TL+W ++ ++ HP++Q+R+Q+E+D  +G      R  
Sbjct: 247 LLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP 306

Query: 347 MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 406
             D+A +P   A I EV R   +VPL + H T+R   + G+ IP+GT +I NL     DE
Sbjct: 307 YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDE 366

Query: 407 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 466
            VWE+P  F P+ FL+      K    L F  G R CLGEPLAR+ELF+  T LLQ F+ 
Sbjct: 367 TVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 422

Query: 467 SVPTGQPRPS 476
            +P+G   PS
Sbjct: 423 -LPSGDALPS 431


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  104 bits (259), Expect = 2e-22
 Identities = 113/484 (23%), Positives = 193/484 (39%), Gaps = 57/484 (11%)

Query: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFG 66
           L + V++ LL +   H    +     PGP PLP LGN+L     +  +C FD +  +++G
Sbjct: 13  LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSY---HKGFCMFDMECHKKYG 69

Query: 67  DVFSLQLAWTPVVVLNGLAAVREALVT--HGEDTADRPPVPITQILGFGPRSQGVFLARY 124
            V+       PV+ +     ++  LV   +   T  RP  P+      G     + +A  
Sbjct: 70  KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV------GFMKSAISIAE- 122

Query: 125 GPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHS--GRPFRPNGLLDKAV 182
              W+  R     T  +  L  K +   + +    L       +  G+P     +     
Sbjct: 123 DEEWKRLRSLLSPTFTSGKL--KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180

Query: 183 SNVIASLTCG--------------------RRFEYDDPRFLRLLDLAQEGLKEESGFLRE 222
            +VI S + G                     RF++ DP FL +             FL  
Sbjct: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP---------FLIP 231

Query: 223 VLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKA 282
           +L     +L+I     +V  F +  + ++ E   E     D  +   D  +  +      
Sbjct: 232 ILE----VLNICVFPREVTNFLRKSVKRMKESRLE-----DTQKHRVDFLQLMIDSQNSK 282

Query: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
           +     + +D  L         AG  TTS+ L++ +  +  HPDVQ+++Q+EID V+   
Sbjct: 283 ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNK 342

Query: 343 RRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSV 402
             P       M Y   V++E  R   I  + +  +  +D+E+ G  IPKG  ++    ++
Sbjct: 343 APPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401

Query: 403 LKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQ 462
            +D   W +P +F PE F       + P  + PF +G R C+G   A M + L    +LQ
Sbjct: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461

Query: 463 HFSF 466
           +FSF
Sbjct: 462 NFSF 465


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  100 bits (248), Expect = 4e-21
 Identities = 63/199 (31%), Positives = 96/199 (48%), Gaps = 2/199 (1%)

Query: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326
           P ++   AFL  +     +  +  + E++   V      G  TT+  + W L L+  +P+
Sbjct: 291 PSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPE 350

Query: 327 VQRRVQQEIDDVIGQVRRPE-MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQ 385
           VQ++V  E+DDV G+  RP  + D   + Y   VI E  R    VPL      S D EV 
Sbjct: 351 VQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVA 409

Query: 386 GFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLG 445
           G+R+ KGT  +    ++ +D   +  P  F PE F         P A++PFSAG R C+G
Sbjct: 410 GYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIG 469

Query: 446 EPLARMELFLFFTSLLQHF 464
           +  A ME     + +L+HF
Sbjct: 470 QKFAVMEEKTILSCILRHF 488


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 114/479 (23%), Positives = 191/479 (39%), Gaps = 37/479 (7%)

Query: 35  PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT 93
           PGP PLP LGN L   F+   + FD +  +++  V+ +     P++ +     ++  LV 
Sbjct: 39  PGPTPLPFLGNAL--SFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVK 96

Query: 94  --HGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ 151
             +   T  RP  P+      G     + +A     W+  R     T  +  L  K +  
Sbjct: 97  ECYSVFTNRRPFGPV------GFMKNAISIAE-DEEWKRIRSLLSPTFTSGKL--KEMVP 147

Query: 152 WVTEEAACLCAAFANHS--GRPFRPNGLLDKAVSNVIASLTCGRRFEY----DDP----- 200
            + +    L       +  G+P     +      +VI S + G   +      DP     
Sbjct: 148 IIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENT 207

Query: 201 -RFLRLLDLAQEGLK-EESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEH 258
            + LR   L    L  +   FL  +L A    L+I     KV+    +FLT+  + + E 
Sbjct: 208 KKLLRFNPLDPFVLSIKVFPFLTPILEA----LNITVFPRKVI----SFLTKSVKQIKEG 259

Query: 259 RMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGL 318
           R+  +  +   D  +  +            + +D  L         AG  TTS+ L++ +
Sbjct: 260 RLK-ETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFII 318

Query: 319 LLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMT 378
             +  HPDVQ++VQ+EID V+     P       + Y   V++E  R   +  + +  + 
Sbjct: 319 YELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVA-MRLERVC 377

Query: 379 SRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSA 438
            +D+E+ G  IPKG  ++     +  D   W +P +F PE F       + P  + PF +
Sbjct: 378 KKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGS 437

Query: 439 GRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR 497
           G R C+G   A + + L    +LQ+FSF        P        L+T  P  L A  R
Sbjct: 438 GPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 110/461 (23%), Positives = 180/461 (39%), Gaps = 64/461 (13%)

Query: 35  PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT 93
           PGP PLP LGN+L   ++   + FD +  +++G ++       PV+ +     +R  LV 
Sbjct: 39  PGPTPLPLLGNVL--SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVK 96

Query: 94  --HGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ 151
             +   T  R   P+      G     + LA     W+  R     T  +  L  K +  
Sbjct: 97  ECYSVFTNRRSLGPV------GFMKSAISLAE-DEEWKRIRSLLSPTFTSGKL--KEMFP 147

Query: 152 WVTEEAACLCAAFANHS--GRPFRPNGLLDKAVSNVIASLTCG----------------- 192
            + +    L       +  G+P     +      +VI   + G                 
Sbjct: 148 IIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVEST 207

Query: 193 ---RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH----IPALAGKVLRFQK 245
               +F + DP FL ++            FL  V  A+ V L     I  L+  V R +K
Sbjct: 208 KKFLKFGFLDPLFLSIILFP---------FLTPVFEALNVSLFPKDTINFLSKSVNRMKK 258

Query: 246 AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSA 305
           + L    +    HR+         D  +  +      +     + +D  L         A
Sbjct: 259 SRLNDKQK----HRL---------DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA 305

Query: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR 365
           G  TTS+ L++ L  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365

Query: 366 FGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 425
               V + +     +D+E+ G  IPKG+ ++    ++  D   W +P  F PE F   + 
Sbjct: 366 LFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKK 423

Query: 426 HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 466
             + P  + PF  G R C+G   A M + L    +LQ+FSF
Sbjct: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 62/192 (32%), Positives = 102/192 (53%), Gaps = 8/192 (4%)

Query: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTA 358
           V ++  AG+ TTS TL+W + L+  HP+VQ+ V +EI   +G+   P   D   +P   A
Sbjct: 174 VTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRA 233

Query: 359 VIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTL-ITNLSSVLKDEAVWEKPFRFHP 417
           ++ E  R   ++P G   +T  D+ + G+ IPKGT L + + ++  +DE  + +   F P
Sbjct: 234 LLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDEN-FPRAKEFRP 291

Query: 418 EHFLDAQGHFVKPEAF--LPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRP 475
           E +L  +G   + + F  +PF  G R+C+G  +A +E+ L    LLQH  F + T     
Sbjct: 292 ERWL-RKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQH--FEIKTSSQTN 348

Query: 476 SHHGVFAFLVTP 487
           + H     L+TP
Sbjct: 349 AVHAKTHGLLTP 360


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,488,406
Number of Sequences: 37866
Number of extensions: 963216
Number of successful extensions: 3039
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2827
Number of HSP's gapped (non-prelim): 98
length of query: 497
length of database: 18,247,518
effective HSP length: 106
effective length of query: 391
effective length of database: 14,233,722
effective search space: 5565385302
effective search space used: 5565385302
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.