Search of human proteins with 40255245

Search of human proteins with 40255245

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
         (941 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40255245 G protein-coupled receptor 51 [Homo sapiens]             1908   0.0  
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...   477   e-134
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform...   473   e-133
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...   473   e-133
gi|23308585 G protein-coupled receptor 156 [Homo sapiens]             150   4e-36
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur...    72   2e-12
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur...    69   3e-11
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur...    65   2e-10
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs...    65   3e-10
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso...    65   3e-10
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]           64   7e-10
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso...    64   9e-10
gi|93352554 GPR158-like 1 [Homo sapiens]                               60   1e-08
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ...    59   2e-08
gi|37577159 calcium-sensing receptor [Homo sapiens]                    58   4e-08
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s...    57   6e-08
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]            56   1e-07
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre...    56   2e-07
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr...    56   2e-07
gi|134152694 guanylate cyclase 2F [Homo sapiens]                       55   2e-07
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]          53   1e-06
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]          53   1e-06
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs...    53   1e-06
gi|112807234 G protein-coupled receptor, family C, group 6, memb...    52   3e-06
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]           48   4e-05
gi|4505441 natriuretic peptide receptor C/guanylate cyclase C (a...    46   1e-04
gi|93204867 G protein-coupled receptor 158 [Homo sapiens]              46   1e-04
gi|63025220 ring finger protein 215 [Homo sapiens]                     44   7e-04
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]             44   0.001
gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens]           42   0.002

>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
          Length = 941

 Score = 1908 bits (4942), Expect = 0.0
 Identities = 941/941 (100%), Positives = 941/941 (100%)

Query: 1   MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMG 60
           MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMG
Sbjct: 1   MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMG 60

Query: 61  LMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDA 120
           LMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDA
Sbjct: 61  LMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDA 120

Query: 121 IKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN 180
           IKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN
Sbjct: 121 IKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN 180

Query: 181 AVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSV 240
           AVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSV
Sbjct: 181 AVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSV 240

Query: 241 KKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSS 300
           KKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSS
Sbjct: 241 KKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSS 300

Query: 301 RCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYD 360
           RCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYD
Sbjct: 301 RCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYD 360

Query: 361 GIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNG 420
           GIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNG
Sbjct: 361 GIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNG 420

Query: 421 ERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLP 480
           ERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLP
Sbjct: 421 ERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLP 480

Query: 481 LYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLD 540
           LYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLD
Sbjct: 481 LYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLD 540

Query: 541 GSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVI 600
           GSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVI
Sbjct: 541 GSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVI 600

Query: 601 VGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIV 660
           VGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIV
Sbjct: 601 VGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIV 660

Query: 661 YAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQ 720
           YAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQ
Sbjct: 661 YAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQ 720

Query: 721 FCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSV 780
           FCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSV
Sbjct: 721 FCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSV 780

Query: 781 NQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNL 840
           NQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNL
Sbjct: 781 NQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNL 840

Query: 841 GNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILH 900
           GNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILH
Sbjct: 841 GNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILH 900

Query: 901 HAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL 941
           HAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
Sbjct: 901 HAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL 941


>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
           precursor [Homo sapiens]
          Length = 844

 Score =  477 bits (1228), Expect = e-134
 Identities = 286/811 (35%), Positives = 448/811 (55%), Gaps = 46/811 (5%)

Query: 29  LPLLLPLAPG-AWGWARGAP---RPPPSSPP--------LSIMGLMPLTKEVAKGSIGRG 76
           LPLL+ +A G A  WA  +P   RP    PP        + I  L P++        G+ 
Sbjct: 14  LPLLVVMAAGVAPVWASHSPHLPRPHSRVPPHPSSERRAVYIGALFPMS---GGWPGGQA 70

Query: 77  VLPAVELAIEQIRNE-SLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVC 135
             PAVE+A+E + +   +L  Y L L  +D++CD  +  K  Y+ +   P  +++  G C
Sbjct: 71  CQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPG-C 129

Query: 136 PSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQW 195
            SV++++AE+ + WNL+ LS+ +++P L++++++P FFRT PS    NP  +KL + + W
Sbjct: 130 SSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 189

Query: 196 KRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQF 255
           K++ T+ Q  + F+   +DL   +    IEI+  +SF +DP   VK LK  D RII+G F
Sbjct: 190 KKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLF 249

Query: 256 DQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYI 315
            +  A KVFC  Y+E ++G KY W + GWY  +W++      N   C    +  A+EG+I
Sbjct: 250 YETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSIN---CTVDEMTEAVEGHI 306

Query: 316 GVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGY-----AYDGIWVIAKTLQ 370
             +   L+    ++IS  T Q++  +   KR    P +  G+     AYD IW +A  L 
Sbjct: 307 TTEIVMLNPANTRSISNMTSQEFVEKLT-KRLKRHPEETGGFQEAPLAYDAIWALALALN 365

Query: 371 RAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVF-RNGERMGTIKFT 429
           +       S    R++DFNY + T+   I  AMN ++F GV+G VVF  +G RM      
Sbjct: 366 KTSGGGGRSG--VRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIE 423

Query: 430 QFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALT 489
           Q Q     K+G Y++  D L   + T ++ G  PP D+T++++  R +S  L+  +S L+
Sbjct: 424 QLQGGSYKKIGYYDSTKDDLSW-SKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLS 482

Query: 490 ILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTF 549
            LG+++A   L FNI N + + I+ S P +NNL  +G  L+ A++F  GLDG  +    F
Sbjct: 483 SLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQF 542

Query: 550 ETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKK---KIIKDQKLLVIVGGMLL 606
             +C  R W+L +G++  +G+MF K W VH +F   + KK   K ++  KL   VG ++ 
Sbjct: 543 PFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVG 602

Query: 607 IDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGL 666
           +D+  L  WQ VDPL RT+E ++ E      D+SI P LEHC +  M  WLGI Y YKGL
Sbjct: 603 MDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGL 662

Query: 667 LMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVAL 726
           L+L G FLA+ET++VS   +ND + +GM++YNV ++C+I A V+ +   Q +  F   +L
Sbjct: 663 LLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASL 722

Query: 727 VIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTS 786
            I+F S ITL ++FVPK+  L T  +           Q++ ++  KT +S T+ N+   S
Sbjct: 723 AIVFSSYITLVVLFVPKMRRLITRGE----------WQSEAQDTMKTGSS-TNNNEEEKS 771

Query: 787 RLEGLQSENHRLRMKITELDKDLEEVTMQLQ 817
           RL  L+ EN  L   I E ++ + E+  QLQ
Sbjct: 772 RL--LEKENRELEKIIAEKEERVSELRHQLQ 800


>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
           precursor [Homo sapiens]
          Length = 899

 Score =  473 bits (1216), Expect = e-133
 Identities = 269/754 (35%), Positives = 425/754 (56%), Gaps = 31/754 (4%)

Query: 74  GRGVLPAVELAIEQIRNE-SLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFG 132
           G+   PAVE+A+E + +   +L  Y L L  +D++CD  +  K  Y+ +   P  +++  
Sbjct: 123 GQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMP 182

Query: 133 GVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKH 192
           G C SV++++AE+ + WNL+ LS+ +++P L++++++P FFRT PS    NP  +KL + 
Sbjct: 183 G-CSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEK 241

Query: 193 YQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIIL 252
           + WK++ T+ Q  + F+   +DL   +    IEI+  +SF +DP   VK LK  D RII+
Sbjct: 242 WGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIV 301

Query: 253 GQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAME 312
           G F +  A KVFC  Y+E ++G KY W + GWY  +W++      N   C    +  A+E
Sbjct: 302 GLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSIN---CTVDEMTEAVE 358

Query: 313 GYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGY-----AYDGIWVIAK 367
           G+I  +   L+    ++IS  T Q++  +   KR    P +  G+     AYD IW +A 
Sbjct: 359 GHITTEIVMLNPANTRSISNMTSQEFVEKLT-KRLKRHPEETGGFQEAPLAYDAIWALAL 417

Query: 368 TLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVF-RNGERMGTI 426
            L +       S    R++DFNY + T+   I  AMN ++F GV+G VVF  +G RM   
Sbjct: 418 ALNKTSGGGGRSG--VRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWT 475

Query: 427 KFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILS 486
              Q Q     K+G Y++  D L   + T ++ G  PP D+T++++  R +S  L+  +S
Sbjct: 476 LIEQLQGGSYKKIGYYDSTKDDLSW-SKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVS 534

Query: 487 ALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSE 546
            L+ LG+++A   L FNI N + + I+ S P +NNL  +G  L+ A++F  GLDG  +  
Sbjct: 535 VLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGR 594

Query: 547 KTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKK---KIIKDQKLLVIVGG 603
             F  +C  R W+L +G++  +G+MF K W VH +F   + KK   K ++  KL   VG 
Sbjct: 595 NQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 654

Query: 604 MLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAY 663
           ++ +D+  L  WQ VDPL RT+E ++ E      D+SI P LEHC +  M  WLGI Y Y
Sbjct: 655 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 714

Query: 664 KGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCI 723
           KGLL+L G FLA+ET++VS   +ND + +GM++YNV ++C+I A V+ +   Q +  F  
Sbjct: 715 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAF 774

Query: 724 VALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQA 783
            +L I+F S ITL ++FVPK+  L T  +           Q++ ++  KT +S T+ N+ 
Sbjct: 775 ASLAIVFSSYITLVVLFVPKMRRLITRGE----------WQSEAQDTMKTGSS-TNNNEE 823

Query: 784 STSRLEGLQSENHRLRMKITELDKDLEEVTMQLQ 817
             SRL  L+ EN  L   I E ++ + E+  QLQ
Sbjct: 824 EKSRL--LEKENRELEKIIAEKEERVSELRHQLQ 855


>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
           precursor [Homo sapiens]
          Length = 961

 Score =  473 bits (1216), Expect = e-133
 Identities = 269/754 (35%), Positives = 425/754 (56%), Gaps = 31/754 (4%)

Query: 74  GRGVLPAVELAIEQIRNE-SLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFG 132
           G+   PAVE+A+E + +   +L  Y L L  +D++CD  +  K  Y+ +   P  +++  
Sbjct: 185 GQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMP 244

Query: 133 GVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKH 192
           G C SV++++AE+ + WNL+ LS+ +++P L++++++P FFRT PS    NP  +KL + 
Sbjct: 245 G-CSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEK 303

Query: 193 YQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIIL 252
           + WK++ T+ Q  + F+   +DL   +    IEI+  +SF +DP   VK LK  D RII+
Sbjct: 304 WGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIV 363

Query: 253 GQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAME 312
           G F +  A KVFC  Y+E ++G KY W + GWY  +W++      N   C    +  A+E
Sbjct: 364 GLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSIN---CTVDEMTEAVE 420

Query: 313 GYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGY-----AYDGIWVIAK 367
           G+I  +   L+    ++IS  T Q++  +   KR    P +  G+     AYD IW +A 
Sbjct: 421 GHITTEIVMLNPANTRSISNMTSQEFVEKLT-KRLKRHPEETGGFQEAPLAYDAIWALAL 479

Query: 368 TLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVF-RNGERMGTI 426
            L +       S    R++DFNY + T+   I  AMN ++F GV+G VVF  +G RM   
Sbjct: 480 ALNKTSGGGGRSG--VRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWT 537

Query: 427 KFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILS 486
              Q Q     K+G Y++  D L   + T ++ G  PP D+T++++  R +S  L+  +S
Sbjct: 538 LIEQLQGGSYKKIGYYDSTKDDLSW-SKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVS 596

Query: 487 ALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSE 546
            L+ LG+++A   L FNI N + + I+ S P +NNL  +G  L+ A++F  GLDG  +  
Sbjct: 597 VLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGR 656

Query: 547 KTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKK---KIIKDQKLLVIVGG 603
             F  +C  R W+L +G++  +G+MF K W VH +F   + KK   K ++  KL   VG 
Sbjct: 657 NQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 716

Query: 604 MLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAY 663
           ++ +D+  L  WQ VDPL RT+E ++ E      D+SI P LEHC +  M  WLGI Y Y
Sbjct: 717 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 776

Query: 664 KGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCI 723
           KGLL+L G FLA+ET++VS   +ND + +GM++YNV ++C+I A V+ +   Q +  F  
Sbjct: 777 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAF 836

Query: 724 VALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQA 783
            +L I+F S ITL ++FVPK+  L T  +           Q++ ++  KT +S T+ N+ 
Sbjct: 837 ASLAIVFSSYITLVVLFVPKMRRLITRGE----------WQSEAQDTMKTGSS-TNNNEE 885

Query: 784 STSRLEGLQSENHRLRMKITELDKDLEEVTMQLQ 817
             SRL  L+ EN  L   I E ++ + E+  QLQ
Sbjct: 886 EKSRL--LEKENRELEKIIAEKEERVSELRHQLQ 917


>gi|23308585 G protein-coupled receptor 156 [Homo sapiens]
          Length = 814

 Score =  150 bits (380), Expect = 4e-36
 Identities = 99/348 (28%), Positives = 179/348 (51%), Gaps = 19/348 (5%)

Query: 474 LRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYAS 533
           +  +S  L  I+      G+++   FL F I  R  +++KMSSP +N + +LG  L+Y+S
Sbjct: 42  ISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSS 101

Query: 534 IFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIF-KNVKMKKKII 592
            +LFG+    V   + ETL   R  +L +G +  FG +  K+WR++ +F + V  K+ II
Sbjct: 102 AYLFGIQDVLVG-SSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVII 160

Query: 593 KDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEH-CENT 651
           KD +LL +V  +L+ D+ +L+ W   DP+ + ++  S+     G+D+S      H C + 
Sbjct: 161 KDLQLLGLVAALLMADVILLMTWVLTDPI-QCLQILSVSMTVTGKDVSCTSTSTHFCASR 219

Query: 652 HMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSF 711
           +  +W+ +++  KGLL+L+G +LA  T +VS P +N S  I + V  + +   +   V+ 
Sbjct: 220 YSDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTR 279

Query: 712 LTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDA-----------ATQNRRF 760
                PN+ F + +  I  C+T   C +F+P+L   +   +            +T N+ F
Sbjct: 280 YLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFSTPNKSF 339

Query: 761 QFTQNQKKEDSKTSTSVTSVNQASTSR---LEGLQSENHRLRMKITEL 805
             TQ  ++E+       +S+ +  T +   +E LQ + +  + KI  L
Sbjct: 340 H-TQYGEEENCHPRGEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRL 386


>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
           [Homo sapiens]
          Length = 908

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 79/354 (22%), Positives = 164/354 (46%), Gaps = 47/354 (13%)

Query: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547
           + ILG+I  +  +   ++  +  +++ S   ++ +++ G  L Y+  FL        +  
Sbjct: 590 VAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLM-----IAAPD 644

Query: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGM 604
           T   +C+ R   L +G   ++ A+  KT R+H IF+  K      K I     LVI   +
Sbjct: 645 TI--ICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSL 702

Query: 605 LLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVY 661
           + + L  +  W  VDP    +   E+ +++P+ A      R +L+ C+ + +++   + Y
Sbjct: 703 ISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKA------RGVLK-CDISDLSLICSLGY 755

Query: 662 AYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLT---RDQPN 718
           +   LLM+     A +TR V     N++K IG ++Y   I+ +    + F T    ++  
Sbjct: 756 SI--LLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMY 812

Query: 719 VQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVT 778
           +Q   + + +   ++++L ++++PK+  +  +P+   Q R+  F                
Sbjct: 813 IQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF---------------K 857

Query: 779 SVNQASTSRLEGLQSENHRLRMKI-TELDKDLEEVTMQLQDTPEKTTYIKQNHY 831
           +V  A+T + + +Q  N R   ++ +EL + LE  T     +  KTTYI  +++
Sbjct: 858 AVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNT-----SSTKTTYISYSNH 906



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 29/104 (27%), Positives = 55/104 (52%), Gaps = 7/104 (6%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V G    SV+ ++A  L+ + + Q+S+A+T P L+D  +Y +F R VP D+    A++ +
Sbjct: 150 VIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI 209

Query: 190 LKHYQWKRVGTLTQD-------VQRFSEVRNDLTGVLYGEDIEI 226
           +    W  V TL  +       V+ F+++  ++ GV   +  +I
Sbjct: 210 VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKI 253


>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
           [Homo sapiens]
          Length = 908

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 63/284 (22%), Positives = 135/284 (47%), Gaps = 26/284 (9%)

Query: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547
           + ILG+I  +  +   ++  +  +++ S   ++ +++ G  L Y+  FL        +  
Sbjct: 590 VAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLM-----IAAPD 644

Query: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGM 604
           T   +C+ R   L +G   ++ A+  KT R+H IF+  K      K I     LVI   +
Sbjct: 645 TI--ICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSL 702

Query: 605 LLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVY 661
           + + L  +  W  VDP    +   E+ +++P+ A      R +L+ C+ + +++   + Y
Sbjct: 703 ISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKA------RGVLK-CDISDLSLICSLGY 755

Query: 662 AYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLT---RDQPN 718
           +   LLM+     A +TR V     N++K IG ++Y   I+ +    + F T    ++  
Sbjct: 756 SI--LLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMY 812

Query: 719 VQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQF 762
           +Q   + + +   ++++L ++++PK+  +  +P+   Q R+  F
Sbjct: 813 IQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF 856



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 29/104 (27%), Positives = 55/104 (52%), Gaps = 7/104 (6%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V G    SV+ ++A  L+ + + Q+S+A+T P L+D  +Y +F R VP D+    A++ +
Sbjct: 150 VIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI 209

Query: 190 LKHYQWKRVGTLTQD-------VQRFSEVRNDLTGVLYGEDIEI 226
           +    W  V TL  +       V+ F+++  ++ GV   +  +I
Sbjct: 210 VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKI 253


>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
           [Homo sapiens]
          Length = 1212

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 88/330 (26%), Positives = 142/330 (43%), Gaps = 41/330 (12%)

Query: 491 LGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFE 550
           LG++         I  R+  ++K SS  +  +I+ G  L Y   F        +  K  +
Sbjct: 589 LGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFC-------LIAKPKQ 641

Query: 551 TLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLC 610
             C ++   + +    ++ A+  KT R+  I      KKKI   +   +     L+I   
Sbjct: 642 IYCYLQRIGIGLSPAMSYSALVTKTNRIARILAG--SKKKICTKKPRFMSACAQLVIAF- 698

Query: 611 ILICWQAVDPLRRTVEKYSMEPDPAGRDI-SIRPLLEHCENTHMTIWLGIV--YAYKGLL 667
           ILIC Q    L   V  + MEP     D  SIR +   C  T+    LG+V    Y GLL
Sbjct: 699 ILICIQ----LGIIVALFIMEPPDIMHDYPSIREVYLICNTTN----LGVVTPLGYNGLL 750

Query: 668 MLFGCFLAWETRNVSIPA-LNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVAL 726
           +L   F A++TRNV  PA  N++KYI  ++Y   I+ +    + F      N +   +  
Sbjct: 751 ILSCTFYAFKTRNV--PANFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNYKIITMCF 804

Query: 727 VIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQN--------QKKEDSKTSTSVT 778
            +   +T+ L  +FVPK+  +   P+   +N R  FT +          K  S  S S +
Sbjct: 805 SVSLSATVALGCMFVPKVYIILAKPE---RNVRSAFTTSTVVRMHVGDGKSSSAASRSSS 861

Query: 779 SVN--QASTSRLEGLQSENHRLRMKITELD 806
            VN  +   S  E L+ ++ RL    +E++
Sbjct: 862 LVNLWKRRGSSGETLRYKDRRLAQHKSEIE 891



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 25/72 (34%), Positives = 40/72 (55%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V G    SV   +   LQ +N+ Q++++AT+  L+DK  + YF R VPSD     A++ +
Sbjct: 146 VIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDI 205

Query: 190 LKHYQWKRVGTL 201
           +K Y W  V  +
Sbjct: 206 VKRYNWTYVSAV 217


>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
           [Homo sapiens]
          Length = 922

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 64/284 (22%), Positives = 127/284 (44%), Gaps = 26/284 (9%)

Query: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547
           L +LG+I     +   I+  +  +++ S   ++ +++ G  L Y   FL       +  K
Sbjct: 597 LAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFL-------MIAK 649

Query: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGM 604
               +C+ R   L +G   ++ A+  KT R++ IF+  K      ++I     L I   +
Sbjct: 650 PDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSL 709

Query: 605 LLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVY 661
           + + L  +  W  VDP    +   E  +M P+ A      R +L+ C+ T + I   + Y
Sbjct: 710 ISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQA------RGVLK-CDITDLQIICSLGY 762

Query: 662 AYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPN--- 718
           +   LLM+     A +TR V     N++K IG ++Y   I+ +    + F T        
Sbjct: 763 SI--LLMVTCTVYAIKTRGVP-ENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLY 819

Query: 719 VQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQF 762
           +Q   + + +   +++ L ++++PK+  +  +P+   Q R+  F
Sbjct: 820 IQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSF 863



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 64/248 (25%), Positives = 110/248 (44%), Gaps = 43/248 (17%)

Query: 22  RLLLLLLLP------LLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKE----VAKG 71
           R+L L+  P      LL  LA  A G    AP        +++ GL P+  +    V  G
Sbjct: 9   RVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCG 68

Query: 72  SIGR--GV--LPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---AFYDA--- 120
            I R  G+  L A+  A++QI ++  L P   L  R+ DT   +   L+    F  A   
Sbjct: 69  DIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQ 128

Query: 121 --------------IKYGPNHLM-VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLAD 165
                         +   P  ++ V G    SV+ ++A  L+ + + Q+S+A+T P L+D
Sbjct: 129 KDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSD 188

Query: 166 KKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQD-------VQRFSEVRNDLTGV 218
            ++Y +F R VP D+    A++ ++K   W  V TL  +       V+ F+++  +  G+
Sbjct: 189 DRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGL 248

Query: 219 LYGEDIEI 226
              + + I
Sbjct: 249 CIAQSVRI 256


>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
           [Homo sapiens]
          Length = 915

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 64/284 (22%), Positives = 127/284 (44%), Gaps = 26/284 (9%)

Query: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547
           L +LG+I     +   I+  +  +++ S   ++ +++ G  L Y   FL       +  K
Sbjct: 597 LAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFL-------MIAK 649

Query: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGM 604
               +C+ R   L +G   ++ A+  KT R++ IF+  K      ++I     L I   +
Sbjct: 650 PDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSL 709

Query: 605 LLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVY 661
           + + L  +  W  VDP    +   E  +M P+ A      R +L+ C+ T + I   + Y
Sbjct: 710 ISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQA------RGVLK-CDITDLQIICSLGY 762

Query: 662 AYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPN--- 718
           +   LLM+     A +TR V     N++K IG ++Y   I+ +    + F T        
Sbjct: 763 SI--LLMVTCTVYAIKTRGVP-ENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLY 819

Query: 719 VQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQF 762
           +Q   + + +   +++ L ++++PK+  +  +P+   Q R+  F
Sbjct: 820 IQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSF 863



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 64/248 (25%), Positives = 110/248 (44%), Gaps = 43/248 (17%)

Query: 22  RLLLLLLLP------LLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKE----VAKG 71
           R+L L+  P      LL  LA  A G    AP        +++ GL P+  +    V  G
Sbjct: 9   RVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCG 68

Query: 72  SIGR--GV--LPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---AFYDA--- 120
            I R  G+  L A+  A++QI ++  L P   L  R+ DT   +   L+    F  A   
Sbjct: 69  DIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQ 128

Query: 121 --------------IKYGPNHLM-VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLAD 165
                         +   P  ++ V G    SV+ ++A  L+ + + Q+S+A+T P L+D
Sbjct: 129 KDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSD 188

Query: 166 KKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQD-------VQRFSEVRNDLTGV 218
            ++Y +F R VP D+    A++ ++K   W  V TL  +       V+ F+++  +  G+
Sbjct: 189 DRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGL 248

Query: 219 LYGEDIEI 226
              + + I
Sbjct: 249 CIAQSVRI 256


>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
          Length = 912

 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 64/290 (22%), Positives = 136/290 (46%), Gaps = 31/290 (10%)

Query: 479 LPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFG 538
           LPL+     L ++G+      +   ++  +  ++K S   ++ +++ G  L YA+ FL  
Sbjct: 590 LPLF-----LAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLM- 643

Query: 539 LDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQ 595
                ++E    T C++R   L +G + ++ A+  KT R++ IF+  K      + I   
Sbjct: 644 -----IAEPDLGT-CSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPA 697

Query: 596 KLLVIVGGMLLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTH 652
             L I   ++ + L  +  W  VDP    V   ++ +++P  A      R +L+ C+ + 
Sbjct: 698 SQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFA------RGVLK-CDISD 750

Query: 653 MTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFL 712
           ++  L  +  Y  LLM+     A +TR V     N++K IG ++Y   I+ +    + F 
Sbjct: 751 LS--LICLLGYSMLLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIVWLAFIPIFFG 807

Query: 713 T---RDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRR 759
           T    D+  +Q   + + +   ++++L ++++PK+  +  +P+     R+
Sbjct: 808 TSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRK 857



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 39/245 (15%)

Query: 21  ARLLLLLLLPLLLPLAPGAWGWARGAPRPPP--SSPPLSIMGLMPLTKEVAKG------- 71
           ARL L LLL L  P  P + G  +G P          +++ GL P+    ++G       
Sbjct: 12  ARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELK 71

Query: 72  -SIGRGVLPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---AFYDAI----- 121
              G   L A+  A+++I N+  L P   L  R+ DT   +   L+    F  A+     
Sbjct: 72  KEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDG 131

Query: 122 ------KYGPNHLM-------VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKK 168
                   GP  +        V G    SV+ ++A  L+ + + Q+S+A+T P L+D  +
Sbjct: 132 TEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSR 191

Query: 169 YPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQD-------VQRFSEVRNDLTGVLYG 221
           Y +F R VPSD     A++ +++  +W  V T+  +       V+ F +   +  GV   
Sbjct: 192 YDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIA 251

Query: 222 EDIEI 226
           + ++I
Sbjct: 252 QSVKI 256


>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
           [Homo sapiens]
          Length = 1180

 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 82/303 (27%), Positives = 129/303 (42%), Gaps = 39/303 (12%)

Query: 491 LGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFE 550
           LG++         I  R+  ++K SS  +  +I+ G  L Y   F        +  K  +
Sbjct: 589 LGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFC-------LIAKPKQ 641

Query: 551 TLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLC 610
             C ++   + +    ++ A+  KT R+  I      KKKI   +   +     L+I   
Sbjct: 642 IYCYLQRIGIGLSPAMSYSALVTKTNRIARILAG--SKKKICTKKPRFMSACAQLVIAF- 698

Query: 611 ILICWQAVDPLRRTVEKYSMEPDPAGRDI-SIRPLLEHCENTHMTIWLGIV--YAYKGLL 667
           ILIC Q    L   V  + MEP     D  SIR +   C  T+    LG+V    Y GLL
Sbjct: 699 ILICIQ----LGIIVALFIMEPPDIMHDYPSIREVYLICNTTN----LGVVTPLGYNGLL 750

Query: 668 MLFGCFLAWETRNVSIPA-LNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVAL 726
           +L   F A++TRNV  PA  N++KYI  ++Y   I+ +    + F      N +   +  
Sbjct: 751 ILSCTFYAFKTRNV--PANFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNYKIITMCF 804

Query: 727 VIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQN--------QKKEDSKTSTSVT 778
            +   +T+ L  +FVPK+  +   P+   +N R  FT +          K  S  S S +
Sbjct: 805 SVSLSATVALGCMFVPKVYIILAKPE---RNVRSAFTTSTVVRMHVGDGKSSSAASRSSS 861

Query: 779 SVN 781
            VN
Sbjct: 862 LVN 864



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 25/72 (34%), Positives = 40/72 (55%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V G    SV   +   LQ +N+ Q++++AT+  L+DK  + YF R VPSD     A++ +
Sbjct: 146 VIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDI 205

Query: 190 LKHYQWKRVGTL 201
           +K Y W  V  +
Sbjct: 206 VKRYNWTYVSAV 217


>gi|93352554 GPR158-like 1 [Homo sapiens]
          Length = 2367

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 58/251 (23%), Positives = 106/251 (42%), Gaps = 24/251 (9%)

Query: 507 RNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTT 566
           R  K I  S   +   ++ G +L Y  +F+      +     F   C    W+  +G+  
Sbjct: 406 RRNKRIWASGVVLLETVLFGFLLLYFPVFIL-----YFKPSVFR--CIALRWVRLLGFAI 458

Query: 567 AFGAMFAKTWRVHAIF-KNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTV 625
            +G +  K +RV  +F      +  ++   +LL  +G +LL  L  L  W  V  L R +
Sbjct: 459 VYGTIILKLYRVLQLFLSRTAQRSALLSSGRLLRRLGLLLLPVLGFLAVW-TVGALERGI 517

Query: 626 EKYSM---EPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVS 682
           +   +      P+GR         H    H   W  I+   + LL+ +G FL + TR V 
Sbjct: 518 QHAPLVIRGHTPSGR---------HFYLCHHDRWDYIMVVAELLLLCWGSFLCYATRAV- 567

Query: 683 IPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTI--TLCLVF 740
           + A ++ +Y+G++++N  ++        F+     +  + ++       ST+  TL L+F
Sbjct: 568 LSAFHEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIF 627

Query: 741 VPKLITLRTNP 751
           +PK   L   P
Sbjct: 628 IPKFWKLGAPP 638


>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
           sapiens]
          Length = 877

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 51/245 (20%)

Query: 30  PLLLPLAPGAWGWARGAPRPPPS---SPPLSIMGLMPLTKEVAKGSIGRGV--------- 77
           PLL+ L P AW    G  R   S   +  L++ GL P+    A+G+ GR           
Sbjct: 10  PLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVH---ARGAAGRACGQLKKEQGV 66

Query: 78  --LPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---AFYDAIKYG------- 124
             L A+  A++++  +  L P   L  RL DT   +   L+   +F  A+  G       
Sbjct: 67  HRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEV 126

Query: 125 ---------------PNHLM-VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKK 168
                          P  ++ V G    SV+ ++A  L+ + + Q+S+A+T P L+D  +
Sbjct: 127 GVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTR 186

Query: 169 YPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQD-------VQRFSEVRNDLTGVLYG 221
           Y +F R VP D+    A++ +++   W  V TL  +       V+ F ++  +  GV   
Sbjct: 187 YDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIA 246

Query: 222 EDIEI 226
           + I+I
Sbjct: 247 QSIKI 251


>gi|37577159 calcium-sensing receptor [Homo sapiens]
          Length = 1078

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 38/145 (26%), Positives = 75/145 (51%), Gaps = 18/145 (12%)

Query: 78  LPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLKA-----------------FYD 119
           L A+  AIE+I +   L P   L  R++DT    +K L+A                 F +
Sbjct: 71  LQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCN 130

Query: 120 AIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSD 179
             ++ P+ + V G     V++ +A  L  + + Q+S+A+++ +L++K ++  F RT+P+D
Sbjct: 131 CSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPND 190

Query: 180 NAVNPAILKLLKHYQWKRVGTLTQD 204
                A+  ++++++W  VGT+  D
Sbjct: 191 EHQATAMADIIEYFRWNWVGTIAAD 215


>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
           sapiens]
          Length = 879

 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 63/302 (20%), Positives = 123/302 (40%), Gaps = 28/302 (9%)

Query: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547
           +  LG +     +   IK+ N  L+K S   +  +++ G  LSY   F F         K
Sbjct: 583 IACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFF-------IAK 635

Query: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVK---MKKKIIKDQKLLVIVGGM 604
               +C +R   L   +   + A+  KT  +  IF  VK    + K I     + I  G+
Sbjct: 636 PSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGL 695

Query: 605 LLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYK 664
           +L+ + ++  W  ++       +Y++      R+  I  L  + +++ M I L     Y 
Sbjct: 696 ILVQIVMVSVWLILE--APGTRRYTLAEK---RETVI--LKCNVKDSSMLISL----TYD 744

Query: 665 GLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIV 724
            +L++     A++TR       N++K+IG ++Y   I+ +    + ++T     VQ   +
Sbjct: 745 VILVILCTVYAFKTRKCP-ENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTM 803

Query: 725 ALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQAS 784
            + +     + L  +F PK+  +   P       R    +         S + T+ +Q+S
Sbjct: 804 CISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNR------FSVSGTGTTYSQSS 857

Query: 785 TS 786
            S
Sbjct: 858 AS 859



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 27/75 (36%), Positives = 45/75 (60%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V GG   SV+  +A  L+ + + Q+S+A+T+  L+DK +Y YF RTVP D     A+ ++
Sbjct: 145 VIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEI 204

Query: 190 LKHYQWKRVGTLTQD 204
           L+ + W  V T+  +
Sbjct: 205 LRFFNWTYVSTVASE 219


>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
          Length = 852

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 16/141 (11%)

Query: 80  AVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---------------AFYDAIKY 123
           A+++A+E+I N+S L P   L   L+DT  +    +K               A+ +  +Y
Sbjct: 75  AMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQY 134

Query: 124 GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVN 183
            P  L V G     +  +  +    + + Q+S+ A+  +L+ ++ +P FFRTVPSD    
Sbjct: 135 QPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQL 194

Query: 184 PAILKLLKHYQWKRVGTLTQD 204
            A  +LL+ + W  V  L  D
Sbjct: 195 TAAAELLQEFGWNWVAALGSD 215


>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
           precursor [Homo sapiens]
          Length = 906

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 71/284 (25%), Positives = 120/284 (42%), Gaps = 31/284 (10%)

Query: 484 ILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSF 543
           I  A + LG+++        +  R+  ++K SS  +  +I+ G  L Y   F        
Sbjct: 595 IAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFT------- 647

Query: 544 VSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGG 603
           +  K   T C ++  ++ +     + A+  KT R+  I      KKKI   +   +    
Sbjct: 648 LIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAG--SKKKICTRKPRFMSAWA 705

Query: 604 MLLIDLCILICWQAVDPLRRTVEKYSMEPD-PAGRDISIRPLLEHCENTHMTIWLGIV-- 660
            ++I   ILI  Q    L   V    MEP  P     SI+ +   C  ++    LG+V  
Sbjct: 706 QVII-ASILISVQ----LTLVVTLIIMEPPMPILSYPSIKEVYLICNTSN----LGVVAP 756

Query: 661 YAYKGLLMLFGCFLAWETRNVSIPA-LNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNV 719
             Y GLL++   + A++TRNV  PA  N++KYI  ++Y   I+ +    + F      N 
Sbjct: 757 LGYNGLLIMSCTYYAFKTRNV--PANFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNY 810

Query: 720 QFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFT 763
           +       +    T+ L  +F PK+  +   P+   +N R  FT
Sbjct: 811 KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE---RNVRSAFT 851



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 26/72 (36%), Positives = 40/72 (55%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V G    SV   +   LQ +++ Q++++AT+  L+DK  Y YF R VPSD     A+L +
Sbjct: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI 218

Query: 190 LKHYQWKRVGTL 201
           +K Y W  V  +
Sbjct: 219 VKRYNWTYVSAV 230


>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
           precursor [Homo sapiens]
          Length = 1194

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 71/284 (25%), Positives = 120/284 (42%), Gaps = 31/284 (10%)

Query: 484 ILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSF 543
           I  A + LG+++        +  R+  ++K SS  +  +I+ G  L Y   F        
Sbjct: 595 IAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFT------- 647

Query: 544 VSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGG 603
           +  K   T C ++  ++ +     + A+  KT R+  I      KKKI   +   +    
Sbjct: 648 LIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAG--SKKKICTRKPRFMSAWA 705

Query: 604 MLLIDLCILICWQAVDPLRRTVEKYSMEPD-PAGRDISIRPLLEHCENTHMTIWLGIV-- 660
            ++I   ILI  Q    L   V    MEP  P     SI+ +   C  ++    LG+V  
Sbjct: 706 QVII-ASILISVQ----LTLVVTLIIMEPPMPILSYPSIKEVYLICNTSN----LGVVAP 756

Query: 661 YAYKGLLMLFGCFLAWETRNVSIPA-LNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNV 719
             Y GLL++   + A++TRNV  PA  N++KYI  ++Y   I+ +    + F      N 
Sbjct: 757 LGYNGLLIMSCTYYAFKTRNV--PANFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNY 810

Query: 720 QFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFT 763
           +       +    T+ L  +F PK+  +   P+   +N R  FT
Sbjct: 811 KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE---RNVRSAFT 851



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 26/72 (36%), Positives = 40/72 (55%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V G    SV   +   LQ +++ Q++++AT+  L+DK  Y YF R VPSD     A+L +
Sbjct: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI 218

Query: 190 LKHYQWKRVGTL 201
           +K Y W  V  +
Sbjct: 219 VKRYNWTYVSAV 230


>gi|134152694 guanylate cyclase 2F [Homo sapiens]
          Length = 1108

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 99/464 (21%), Positives = 174/464 (37%), Gaps = 61/464 (13%)

Query: 80  AVELAIEQI-RNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSV 138
           A  LAIE+I R+ S    Y  +  + + +C  ++ L +F        +H M  G + P+ 
Sbjct: 75  AARLAIERINRDPSFDLSYSFEYVILNEDCQTSRALSSFIS------HHQMASGFIGPTN 128

Query: 139 TSII-AESLQG--WNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQW 195
                A SL G  W+    S+A     L +K  YP F RT+PS   V   ++ ++K++QW
Sbjct: 129 PGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRV---LVTVMKYFQW 185

Query: 196 KRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKL----KGNDVRII 251
              G ++ D   +    N +   L    + +    +   D  +  K L    + + +RII
Sbjct: 186 AHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQADRIRII 245

Query: 252 L-----GQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKN 306
           +               +  CA++  M    Y ++    Y+   +   + +    R LR N
Sbjct: 246 IMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVP---YDALLYSLPY-KHTPYRVLRNN 301

Query: 307 LLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIA 366
                E Y  V    + S++       T      E   K      S   G  Y+ I+ IA
Sbjct: 302 -PKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIA 360

Query: 367 KTLQRAME--------TLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFR 418
           + +  AM+        +L   SR+ +   FN    T          ++N  G++  V+  
Sbjct: 361 QAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRT----------DSNGNGISEYVILD 410

Query: 419 NGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKIS 478
              +   +  T   D             + L      I F G  PP+          KI 
Sbjct: 411 TNLKEWELHSTYTVDME----------MELLRFGGTPIHFPGGRPPRADAKCWFAEGKIC 460

Query: 479 L----PLYSILSALTIL-GMIMASAFLFFNIKNRNQKLIKMSSP 517
                P ++++  LT+L  ++  + F +F I+ R  K+  +  P
Sbjct: 461 HGGIDPAFAMMVCLTLLIALLSINGFAYF-IRRRINKIQLIKGP 503


>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
          Length = 841

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 15/137 (10%)

Query: 74  GRGVLPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAK--------------GLKAFY 118
           G  +  A+ L +E+I N + L P   L  +LYD   D+A                ++   
Sbjct: 72  GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131

Query: 119 DAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 178
           D + Y P  L V G    +  +  A  L  + +  +S+AA++  L+ K++YP F RT+P+
Sbjct: 132 DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPN 191

Query: 179 DNAVNPAILKLLKHYQW 195
           D      ++ LL+ + W
Sbjct: 192 DKYQVETMVLLLQKFGW 208


>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
          Length = 480

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 15/137 (10%)

Query: 74  GRGVLPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAK--------------GLKAFY 118
           G  +  A+ L +E+I N + L P   L  +LYD   D+A                ++   
Sbjct: 72  GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131

Query: 119 DAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 178
           D + Y P  L V G    +  +  A  L  + +  +S+AA++  L+ K++YP F RT+P+
Sbjct: 132 DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPN 191

Query: 179 DNAVNPAILKLLKHYQW 195
           D      ++ LL+ + W
Sbjct: 192 DKYQVETMVLLLQKFGW 208


>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
           [Homo sapiens]
          Length = 872

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 26/75 (34%), Positives = 44/75 (58%)

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
           V GG    V+  +A  L+ + + Q+S+A+T+  L+DK +Y YF RTVP D     A+ ++
Sbjct: 139 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEI 198

Query: 190 LKHYQWKRVGTLTQD 204
           L+ + W  V T+  +
Sbjct: 199 LRFFNWTYVSTVASE 213


>gi|112807234 G protein-coupled receptor, family C, group 6, member
           A [Homo sapiens]
          Length = 926

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 37/138 (26%), Positives = 58/138 (42%), Gaps = 17/138 (12%)

Query: 84  AIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFY-----------------DAIKYGPN 126
           +IE I N +LL    L   +YDT  +    + A                   D   Y P 
Sbjct: 80  SIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139

Query: 127 HLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAI 186
              V G     +T  ++  L    + Q+ + +T  +L+DK ++P F RTVPSD     A+
Sbjct: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAM 199

Query: 187 LKLLKHYQWKRVGTLTQD 204
             L++   W  +G +T D
Sbjct: 200 AHLIQKSGWNWIGIITTD 217


>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
          Length = 839

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 46/182 (25%), Positives = 78/182 (42%), Gaps = 21/182 (11%)

Query: 62  MPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRP-YFLDLRLYDTEC---DNAKGLKAF 117
           +P+ KE     IG  ++ A+  A+E+I N+S L P   L   + D  C   +N + +  F
Sbjct: 56  VPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDV-CYISNNVQPVLYF 114

Query: 118 Y-----------DAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADK 166
                       D   Y    + V G         +A  L  + L Q++++A +  L DK
Sbjct: 115 LAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDK 174

Query: 167 KKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEI 226
            ++P   RT PS +    A+++L+ H++W  +  L       S+      G L GE +  
Sbjct: 175 VRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVS-----SDTYGRDNGQLLGERVAR 229

Query: 227 SD 228
            D
Sbjct: 230 RD 231


>gi|4505441 natriuretic peptide receptor C/guanylate cyclase C
           (atrionatriuretic peptide receptor C) [Homo sapiens]
          Length = 540

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 79/383 (20%), Positives = 144/383 (37%), Gaps = 36/383 (9%)

Query: 77  VLPAVELAIEQIRNESLLRPYF-----LDLRLYDTECDNAKGLKAFYD--AIKYGPNHLM 129
           V PA+E A+  +      R          +   D++C N + L +  D  A   G    +
Sbjct: 72  VRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGN-RALFSLVDRVAAARGAKPDL 130

Query: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADK-KKYPYFFRTVPSDNAVNPAILK 188
           + G VC    + +A     W+L  LS  A       K  +Y +  R  P+   +   +L 
Sbjct: 131 ILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLA 190

Query: 189 LLKHYQWKRVGTLTQDVQRFSEVRNDLTGV--LYGEDIEISDTESFSNDPCTSVKKLKGN 246
           L +H+ W R   +  D +        L GV  ++ E+   +   SF       ++ +  N
Sbjct: 191 LFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRN 250

Query: 247 ---DVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCL 303
                R+++     +    +   A+   M    Y +     +  S +        S +  
Sbjct: 251 IQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGD-----GSWKRG 305

Query: 304 RKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIW 363
            K+   A + Y        SS Q  T+      ++E+     +S V     +   Y  ++
Sbjct: 306 DKHDFEAKQAY--------SSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMF 357

Query: 364 VIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQV-VFRNGER 422
           V  +    A+  L+  + H+ ++   Y+    G+II    N T F G+ GQV +  NG+R
Sbjct: 358 V--EGFHDAI-LLYVLALHEVLR-AGYSKKDGGKIIQQTWNRT-FEGIAGQVSIDANGDR 412

Query: 423 MG---TIKFTQFQDSREVKVGEY 442
            G    I  T  +   +  +G+Y
Sbjct: 413 YGDFSVIAMTDVEAGTQEVIGDY 435


>gi|93204867 G protein-coupled receptor 158 [Homo sapiens]
          Length = 1215

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 61/338 (18%), Positives = 134/338 (39%), Gaps = 26/338 (7%)

Query: 466 DKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIIL 525
           D    +++ + + L + S  +   +L  +       F    R  K I+ S   +   I+ 
Sbjct: 405 DSPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHF----RKAKSIRASGLILLETILF 460

Query: 526 GGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNV 585
           G +L Y  + +   + S     TF   C +  W   +G+ T +G +  K  RV  +F + 
Sbjct: 461 GSLLLYFPVVILYFEPS-----TFR--CILLRWARLLGFATVYGTVTLKLHRVLKVFLSR 513

Query: 586 KMKKKIIKDQKLLVIVGGMLLIDLCILIC---WQAVDPLRRTVEKYSMEPDPAGRDISIR 642
                    Q++  + GG ++  L +++    W  +       +    +    G+  +  
Sbjct: 514 TA-------QRIPYMTGGRVMRMLAVILLVVFWFLIGWTSSVCQNLEKQISLIGQGKTSD 566

Query: 643 PLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIM 702
            L+ +     +  W  +    + L +L+G +L +  R V   A ++ +Y+ ++V+N  I+
Sbjct: 567 HLIFNM--CLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVP-SAFHEPRYMAVAVHNELII 623

Query: 703 CIIGAAVSFL--TRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRF 760
             I   + F+  +R Q +    +         T+T+ L+ +PK      NP        +
Sbjct: 624 SAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAY 683

Query: 761 QFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRL 798
           +   +  +  S  ++S+ S     +   E ++ E  +L
Sbjct: 684 EDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKL 721


>gi|63025220 ring finger protein 215 [Homo sapiens]
          Length = 377

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 24/30 (80%), Positives = 25/30 (83%), Gaps = 2/30 (6%)

Query: 12 PPPPPPPPPARLLLLL-LLPLLLPLA-PGA 39
          PPPPPPPPP+ LLLLL LLPL L LA PGA
Sbjct: 12 PPPPPPPPPSPLLLLLPLLPLWLGLAGPGA 41


>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
          Length = 502

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 26/60 (43%), Positives = 27/60 (45%), Gaps = 6/60 (10%)

Query: 4   PRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMP 63
           P   G+ GPPPPPPP   R         L P  PGA G     P PPP  PP S  G  P
Sbjct: 359 PPPPGRGGPPPPPPPATGR------SGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAP 412



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 30/86 (34%), Positives = 35/86 (40%), Gaps = 32/86 (37%)

Query: 4   PRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMP 63
           P + G P PPPPPPPPP             P + G        P PPP  P L   G   
Sbjct: 386 PGAGGPPMPPPPPPPPP-------------PPSSG------NGPAPPPLPPALVPAG--- 423

Query: 64  LTKEVAKGSIGRGVLPAVELAIEQIR 89
               +A G  GRG L      ++QIR
Sbjct: 424 ---GLAPGG-GRGAL------LDQIR 439


>gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens]
          Length = 666

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 22/36 (61%), Positives = 23/36 (63%)

Query: 4  PRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGA 39
          P  +G   PPPPPPPPP   LL LLL LLL  A GA
Sbjct: 16 PALAGPLPPPPPPPPPPLLPLLPLLLLLLLGAAEGA 51



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 24/41 (58%), Positives = 25/41 (60%), Gaps = 3/41 (7%)

Query: 4  PRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWAR 44
          P +   P PPPPPPPPP    LL LLPLLL L  GA   AR
Sbjct: 15 PPALAGPLPPPPPPPPPP---LLPLLPLLLLLLLGAAEGAR 52


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,990,197
Number of Sequences: 37866
Number of extensions: 1929091
Number of successful extensions: 24022
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 261
Number of HSP's successfully gapped in prelim test: 258
Number of HSP's that attempted gapping in prelim test: 17247
Number of HSP's gapped (non-prelim): 4199
length of query: 941
length of database: 18,247,518
effective HSP length: 112
effective length of query: 829
effective length of database: 14,006,526
effective search space: 11611410054
effective search space used: 11611410054
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.