Search of human proteins with 40255149

Search of human proteins with 40255149

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19
[Homo sapiens]
         (802 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom...  1609   0.0  
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]   494   e-139
gi|166197690 neuronal guanine nucleotide exchange factor isoform...   369   e-102
gi|166197688 neuronal guanine nucleotide exchange factor isoform...   369   e-102
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]            270   5e-72
gi|194473700 Src homology 3 domain-containing guanine nucleotide...   266   4e-71
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]             257   3e-68
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                86   1e-16
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    83   9e-16
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              79   2e-14
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    79   2e-14
gi|38373682 pleckstrin homology domain containing family G membe...    78   3e-14
gi|111154084 pleckstrin homology domain containing family G memb...    78   3e-14
gi|111154088 pleckstrin homology domain containing family G memb...    78   3e-14
gi|111154080 pleckstrin homology domain containing family G memb...    78   3e-14
gi|111154078 pleckstrin homology domain containing family G memb...    78   3e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    78   4e-14
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    78   4e-14
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    75   2e-13
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    75   2e-13
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    74   7e-13
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    74   7e-13
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...    73   9e-13
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...    73   9e-13
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...    73   9e-13
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ...    70   6e-12
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ...    70   6e-12
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H...    70   6e-12
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    70   8e-12
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...    67   9e-11

>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
           sapiens]
          Length = 802

 Score = 1609 bits (4166), Expect = 0.0
 Identities = 802/802 (100%), Positives = 802/802 (100%)

Query: 1   MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPSPVCLDLFPVAPEELRA 60
           MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPSPVCLDLFPVAPEELRA
Sbjct: 1   MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPSPVCLDLFPVAPEELRA 60

Query: 61  PGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPR 120
           PGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPR
Sbjct: 61  PGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPR 120

Query: 121 HTQPQRRASHGSEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVEL 180
           HTQPQRRASHGSEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVEL
Sbjct: 121 HTQPQRRASHGSEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVEL 180

Query: 181 SGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEAR 240
           SGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEAR
Sbjct: 181 SGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEAR 240

Query: 241 SVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSD 300
           SVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSD
Sbjct: 241 SVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSD 300

Query: 301 VASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPD 360
           VASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPD
Sbjct: 301 VASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPD 360

Query: 361 VRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWL 420
           VRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWL
Sbjct: 361 VRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWL 420

Query: 421 FSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTY 480
           FSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTY
Sbjct: 421 FSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTY 480

Query: 481 QRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540
           QRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE
Sbjct: 481 QRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540

Query: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600
           DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV
Sbjct: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600

Query: 601 ELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKL 660
           ELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKL
Sbjct: 601 ELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKL 660

Query: 661 QGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQV 720
           QGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQV
Sbjct: 661 QGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQV 720

Query: 721 QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSAR 780
           QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSAR
Sbjct: 721 QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSAR 780

Query: 781 LRNLRENKRVTSATSKLGEAPV 802
           LRNLRENKRVTSATSKLGEAPV
Sbjct: 781 LRNLRENKRVTSATSKLGEAPV 802


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score =  494 bits (1271), Expect = e-139
 Identities = 320/750 (42%), Positives = 425/750 (56%), Gaps = 55/750 (7%)

Query: 65   WSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQ---------PPALEG 115
            W++  PA      WP +   S    TS     S        PG           P +   
Sbjct: 885  WTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVS-----PGMAFSNMTNFLCPSSPTT 939

Query: 116  PWSPRHTQPQRRASHG-SEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTE 174
            PW+P    P  +   G SE   A  +  + +     G          PG+    QA   E
Sbjct: 940  PWTPELQGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASG-------PGRSPVGQARQPE 992

Query: 175  EPRVELSGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKA 234
            +P       + + LE        AS    R  S    G +S+ +A+    G    +    
Sbjct: 993  KP-------SHLHLE-------KASSWPHRRDSGRPPG-DSSGQAVAPSEGANKHKGWSR 1037

Query: 235  SGMEARSVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNS-V 293
             G+   S+   G   SR    +   G      +  +E+ P        RR S+ + +S +
Sbjct: 1038 QGLRRPSILPEGSSDSRGPAVEKHPGP--SDTVVFREKKPKEVMGGFSRRCSKLINSSQL 1095

Query: 294  LYQEYSDVASARELRRQQREE---EGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGS 350
            LYQEYSDV   +E++ QQR E   E PG  +      P  PR  L  S S+  QR +  S
Sbjct: 1096 LYQEYSDVVLNKEIQSQQRLESLSETPGPSS------PRQPRKALVSSESY-LQRLSMAS 1148

Query: 351  TFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSE 410
            + SLWQ+IP VR S VL +++  D KLQE KFELI SEASY+ SL++AV HF  S  L  
Sbjct: 1149 SGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRA 1208

Query: 411  CLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYV 470
             L  Q+ QWLFS+L +V+  S  FL DLE+  E ++  F VCDVVL+H P FRRVYLPYV
Sbjct: 1209 TLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYV 1268

Query: 471  TNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENIL 530
            TNQ YQERT+Q L+  N  F  +L +LE  PVCQRL L SFLILPFQRITRLK+L++NIL
Sbjct: 1269 TNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNIL 1328

Query: 531  KRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQA 590
            KRT  GS +E  ATKA +AL++L+++CN +VQSM+RTEELI+LS+KI FE KIFPLISQ+
Sbjct: 1329 KRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQS 1388

Query: 591  RWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAE 650
            RWLV+ GEL  L    A+P  + KL+++ V+LHLFNDCLLLSR +E  +F VF HA  + 
Sbjct: 1389 RWLVKSGELTAL-EFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSS 1447

Query: 651  LQVRDLSLKLQGIPGHVFLLQLLHG-QHMKHQFLLRARTESEKQRWISALCPSSPQEDKE 709
            ++     +KL G   ++F L L    Q  + +FL R  T+SEK RWISAL  + P+E+ +
Sbjct: 1448 IRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISAL--AMPREELD 1505

Query: 710  VISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQA 769
            ++ E  + PQVQC+R YK    DEL LEK D++ V   +SDGWLEGVRL+DGE+GW P  
Sbjct: 1506 LL-ECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQ 1564

Query: 770  YVEEISSLSARLRNLRENKRVTSATSKLGE 799
             VE IS+   R +NL+E  RV +A  +L E
Sbjct: 1565 QVEFISNPEVRAQNLKEAHRVKTAKLQLVE 1594


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score =  369 bits (948), Expect = e-102
 Identities = 214/515 (41%), Positives = 309/515 (60%), Gaps = 21/515 (4%)

Query: 293 VLYQEYSDVASAREL--RRQQ------------REEEGPGDEAEGAEEGP--GPPRANLS 336
           +LYQEY D ++ +E+  RRQQ              E+ P +E E  EE     PP     
Sbjct: 85  LLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTL 144

Query: 337 PSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLS 396
           P     +   +R   F+LWQD+P++R SGVL  L   + KLQEA FEL+TSEASY  SL+
Sbjct: 145 PQICLLSNPHSR---FNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLN 201

Query: 397 VAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVL 456
           + V HF+ +  + + L   +   LFS + +V + SERFL +LE R+E +++   VCD+V 
Sbjct: 202 LLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVY 261

Query: 457 DHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPF 516
            +      VY+ YV+NQ YQERTY++LL E   F  ++A+LE  P C+ LP +SFLILPF
Sbjct: 262 RYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPF 321

Query: 517 QRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKK 576
           QRITRLK+LV+NILKR  + SE E  A  A   L+ +V+ CN  V+ M RTE++I + KK
Sbjct: 322 QRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKK 381

Query: 577 IHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKE 636
           + F+ K  P+IS +RWL++ GEL +++    +   + K     +YL LFND L++ R+  
Sbjct: 382 MEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIP 441

Query: 637 LGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLL-HGQHMKHQFLLRARTESEKQRW 695
             K+ VF  A    L+V +L  + Q +  +VF+L+LL +    +  ++L+A ++SE +RW
Sbjct: 442 GDKYQVFDSAPRGLLRVEELEDQGQTL-ANVFILRLLENADDREATYMLKASSQSEMKRW 500

Query: 696 ISALCPSSPQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEG 755
           +++L P+   +     S   DCPQVQCV  Y A  PDELTLE  DIL++   T DGW+ G
Sbjct: 501 MTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFG 560

Query: 756 VRLADGEKGWVPQAYVEEISSLSARLRNLRENKRV 790
            RL D E+GW P +  EEI +   R +NL+E  RV
Sbjct: 561 ERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRV 595


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score =  369 bits (948), Expect = e-102
 Identities = 214/515 (41%), Positives = 309/515 (60%), Gaps = 21/515 (4%)

Query: 293 VLYQEYSDVASAREL--RRQQ------------REEEGPGDEAEGAEEGP--GPPRANLS 336
           +LYQEY D ++ +E+  RRQQ              E+ P +E E  EE     PP     
Sbjct: 177 LLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTL 236

Query: 337 PSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLS 396
           P     +   +R   F+LWQD+P++R SGVL  L   + KLQEA FEL+TSEASY  SL+
Sbjct: 237 PQICLLSNPHSR---FNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLN 293

Query: 397 VAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVL 456
           + V HF+ +  + + L   +   LFS + +V + SERFL +LE R+E +++   VCD+V 
Sbjct: 294 LLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVY 353

Query: 457 DHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPF 516
            +      VY+ YV+NQ YQERTY++LL E   F  ++A+LE  P C+ LP +SFLILPF
Sbjct: 354 RYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPF 413

Query: 517 QRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKK 576
           QRITRLK+LV+NILKR  + SE E  A  A   L+ +V+ CN  V+ M RTE++I + KK
Sbjct: 414 QRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKK 473

Query: 577 IHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKE 636
           + F+ K  P+IS +RWL++ GEL +++    +   + K     +YL LFND L++ R+  
Sbjct: 474 MEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIP 533

Query: 637 LGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLL-HGQHMKHQFLLRARTESEKQRW 695
             K+ VF  A    L+V +L  + Q +  +VF+L+LL +    +  ++L+A ++SE +RW
Sbjct: 534 GDKYQVFDSAPRGLLRVEELEDQGQTL-ANVFILRLLENADDREATYMLKASSQSEMKRW 592

Query: 696 ISALCPSSPQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEG 755
           +++L P+   +     S   DCPQVQCV  Y A  PDELTLE  DIL++   T DGW+ G
Sbjct: 593 MTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFG 652

Query: 756 VRLADGEKGWVPQAYVEEISSLSARLRNLRENKRV 790
            RL D E+GW P +  EEI +   R +NL+E  RV
Sbjct: 653 ERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRV 687


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score =  270 bits (689), Expect = 5e-72
 Identities = 185/545 (33%), Positives = 282/545 (51%), Gaps = 34/545 (6%)

Query: 264 EPRLDTQEEPPLGSRSTNERR--QSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEA 321
           EP       P    ++   +R  +  F  +  LYQE  +    R L   Q  ++   DE+
Sbjct: 183 EPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQE----RGLNTSQESDDDILDES 238

Query: 322 EGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAK 381
             + EG     A +   S   AQ +        W  +P+V   G+L  LS  + K QEA 
Sbjct: 239 S-SPEGTQKVDATIVVKSYRPAQVT--------WSQLPEVVELGILDQLSTEERKRQEAM 289

Query: 382 FELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQR 441
           FE++TSE SY HSLS+ V  FL S EL   +   +   LFS + +V   S+RF +DLEQR
Sbjct: 290 FEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQR 349

Query: 442 LEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESP 501
            +A VL   + D++ +H       Y+ Y +N+ YQ+RT Q+L+  N  F   L  +E  P
Sbjct: 350 HKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRP 409

Query: 502 VCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASV 561
            C  LP+ SFLILP QR+TRL +L++ +  +T   SE    A++A  A+ +LV++CN   
Sbjct: 410 ACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGA 469

Query: 562 QSMKRTEELIHLSKKIHF-EGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSK-A 619
             M+R E++  L  ++ F + K  PLIS +RWL++ GEL     L        K++S+  
Sbjct: 470 HRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELF----LVEETGLFRKIASRPT 525

Query: 620 VYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPG---------HVFLL 670
            YL LFND L+++++K    + V  +A+M  +QV  +      +PG         H F +
Sbjct: 526 CYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQV 585

Query: 671 QLL-HGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRTYKAL 729
            LL + +  + Q LL + + S++ RWI AL  S  Q   + +S   D PQV+  + + A 
Sbjct: 586 TLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQ--WQGLSSKGDLPQVEITKAFFAK 643

Query: 730 HPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKR 789
             DE+TL++ D++ V     DGWL G RL DGE GW P+ +   I+S  A   N+R  +R
Sbjct: 644 QADEVTLQQADVVLV-LQQEDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRMER 702

Query: 790 VTSAT 794
           +   T
Sbjct: 703 LRVET 707


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score =  266 bits (681), Expect = 4e-71
 Identities = 169/519 (32%), Positives = 271/519 (52%), Gaps = 49/519 (9%)

Query: 291 NSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGS 350
           N+VLYQ Y + A   +   +   +E   DE       P                      
Sbjct: 376 NAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKP---------------------- 413

Query: 351 TFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSE 410
             S W  +  V+  G+  T+S  + K QEA FE+I+SE SY+ SL + +  F  S ELS+
Sbjct: 414 LRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSD 473

Query: 411 CLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYV 470
            +   ++  LFS + +V   S++F  +LE R + ++    + D+V  H  +    Y+ Y 
Sbjct: 474 TMTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYC 533

Query: 471 TNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENIL 530
           TN+ YQ+RT Q+LL  NP F  +L+R+E    C+ LP+ SFLILP QR+TRL +L++ I 
Sbjct: 534 TNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTIC 593

Query: 531 KRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQA 590
           ++T + S   ++  +A   + +LV+ CN   + M+RTE +  ++ ++ F+ K FPL+S +
Sbjct: 594 QKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSS 653

Query: 591 RWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAE 650
           RWLV+ GEL   A +        + S + VY  LFND L+++++K    + V  ++   +
Sbjct: 654 RWLVKRGELT--AYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQ 711

Query: 651 LQVRDL-SLKLQGIPG---------------HVFLLQLLHGQ-HMKHQFLLRARTESEKQ 693
           L V    + +L   PG               H+F L +L    + K + LL A T+SE+ 
Sbjct: 712 LLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERA 771

Query: 694 RWISALCPSS--PQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDG 751
           RWI+AL  SS  P  D+  ++      QV+ VR++ A  PDEL+L+  D++ +    SDG
Sbjct: 772 RWITALGHSSGKPPADRTSLT------QVEIVRSFTAKQPDELSLQVADVVLIYQRVSDG 825

Query: 752 WLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRV 790
           W EG RL DGE+GW P    +EI+  +   +N+    R+
Sbjct: 826 WYEGERLRDGERGWFPMECAKEITCQATIDKNVERMGRL 864


>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score =  257 bits (657), Expect = 3e-68
 Identities = 176/487 (36%), Positives = 258/487 (52%), Gaps = 17/487 (3%)

Query: 319 DEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQ 378
           +E  G  E   P  AN   + +F      R +   LWQ++P V+ SG+L TLS ++ ++Q
Sbjct: 363 EELWGVGEDGSPSPANAGDAPTFPRPPGPRNT---LWQELPAVQASGLLDTLSPQERRMQ 419

Query: 379 EAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDL 438
           E+ FE++TSEASY+ SL +    F+ S  L + L  +D   LFS +  V+  SERFL  L
Sbjct: 420 ESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATL 479

Query: 439 EQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLE 498
             R+ +      +CDVV  H      VY+ YV NQ YQE TY RL+  N RF   L RL+
Sbjct: 480 LSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQ 539

Query: 499 ESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECN 558
             P C+RLPL SFL+LPFQRITRL+ML++NIL++T +GS  ++ A KA  A+ ++++ C+
Sbjct: 540 SLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCS 599

Query: 559 ASVQSMKRTEELIHLSKKIHF-EGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSS 617
           A V  MK+TEELI L++++ F + K  PL+S +R L   GEL EL           +   
Sbjct: 600 AEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRF 659

Query: 618 KAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLL--HG 675
             + L LF+D LL+++ K   +  V  +A  + +Q + +     G P   F L LL  H 
Sbjct: 660 TPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVP-DPSGPP--TFRLSLLSNHQ 716

Query: 676 QHMKHQFLLRARTESEKQRWISALCPSSPQE-DKEVISEGEDCPQVQCVRTYKALHPDEL 734
               H+ LL+A + S+ QRW+ A     P     + I E  DC Q  C  +      +  
Sbjct: 717 GRPTHR-LLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGR 775

Query: 735 TLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRVTSAT 794
           +LE          T +GWL+G+       G  P   V E++    R R+LR+N+R+  A 
Sbjct: 776 SLESRAAPKHLHKTPEGWLKGL------PGAFPAQLVCEVTGEHERRRHLRQNQRLLEAV 829

Query: 795 SKLGEAP 801
                 P
Sbjct: 830 GSSSGTP 836


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 92/401 (22%), Positives = 171/401 (42%), Gaps = 27/401 (6%)

Query: 366  VLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLP 425
            +L  L+  + K Q    ELI +E +Y++ L +    F      SE L  ++   +F    
Sbjct: 1227 LLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWK 1286

Query: 426  EVKSTSERFLQDLEQR--LEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRL 483
            E+   + + L+ L  R  +  + +   +   +L       + Y+ + + Q       Q+ 
Sbjct: 1287 ELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQK 1346

Query: 484  LLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMA 543
              E P F   + RL   P C+ +PL+SF++ P QR+TR  ++++NIL+ T +   D    
Sbjct: 1347 TDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHL 1406

Query: 544  TKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELA 603
              A    +EL  + N  V+  + ++ L  +   +  EG        +  LV +     L 
Sbjct: 1407 KHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEG-------LSEQLVFNSVTNCLG 1459

Query: 604  PLPAAPPAKL--KLSSKAVYLHLFNDCLLLSR-RKELGKFAV-FVHAKMAELQ------- 652
            P       KL    S+K +Y  LFND LLL++  K LG      V +  + LQ       
Sbjct: 1460 PRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTP 1519

Query: 653  --VRDLSLKLQGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEV 710
              + ++ +KL   P       + H  H+   + LRA + +E+  W+  +  +S   +  +
Sbjct: 1520 IFLNEVLVKLPTDPSGD--EPIFHISHIDRVYTLRAESINERTAWVQKIKAAS---ELYI 1574

Query: 711  ISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDG 751
             +E +   +   VR+ +A     L +   + + ++   S G
Sbjct: 1575 ETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHG 1615



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 21/64 (32%), Positives = 35/64 (54%), Gaps = 3/64 (4%)

Query: 721  QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEK---GWVPQAYVEEISSL 777
            Q + +Y A  P++LTL    ++ +R     GW EG   A G+K   GW P  YV+ +S  
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139

Query: 778  SARL 781
            ++++
Sbjct: 1140 TSKI 1143



 Score = 37.0 bits (84), Expect = 0.073
 Identities = 24/94 (25%), Positives = 44/94 (46%), Gaps = 5/94 (5%)

Query: 710 VISEGEDCP--QVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVP 767
           V+ +GE     Q Q +  ++A   + L   K D+++V       W   V+   G+KGW P
Sbjct: 906 VLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQ---GQKGWFP 962

Query: 768 QAYVEEISSLSARLRNLRENKRVTSATSKLGEAP 801
           ++YV+ IS    +  ++      + A+ K   +P
Sbjct: 963 KSYVKLISGPIRKSTSMDSGSSESPASLKRVASP 996



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 17/91 (18%)

Query: 726 YKALHP------DELTLEKTDILSVR-TWTSD------GWLEGVRLADGEKGWVPQAYVE 772
           Y+AL+P      DE+T++  DI+ V+  W  +      GWL G     G+ GW P  Y E
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGE--LKGKTGWFPANYAE 802

Query: 773 EI--SSLSARLRNLRENKRVTSATSKLGEAP 801
           +I  + + A ++ + ++    +    L E P
Sbjct: 803 KIPENEVPAPVKPVTDSTSAPAPKLALRETP 833


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 69/277 (24%), Positives = 124/277 (44%), Gaps = 17/277 (6%)

Query: 371 SLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELS-----ECLGAQDKQWLFSKLP 425
           S +  + Q AK EL  +E++Y++ L+  +  F    E         L  ++ + +F  +P
Sbjct: 417 SKQSARWQVAK-ELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIP 475

Query: 426 EVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLL 485
           ++     +   DLE  +       S+ D+ L +     + Y P+V      + T  +   
Sbjct: 476 DIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEK 535

Query: 486 ENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATK 545
           + PRF   L   +  P C R  L   LI P QR+  + +L+ ++ K TA  + D+    K
Sbjct: 536 QKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEK 595

Query: 546 AFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPL 605
           A  +LKE++   N   +  +  +++  +  ++  +G    L+S  R LV+  E + L   
Sbjct: 596 AIGSLKEVMTHINEDKRKTEAQKQIFDVVYEV--DGCPANLLSSHRSLVQRVETISLGEH 653

Query: 606 PAAPPAKLKLSSKAVYLHLFNDCLLLSRR--KELGKF 640
           P           + V L LFNDCL ++R+  K +G F
Sbjct: 654 PCD-------RGEQVTLFLFNDCLEIARKRHKVIGTF 683


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 80/325 (24%), Positives = 147/325 (45%), Gaps = 28/325 (8%)

Query: 383 ELITSEASYIHSL----SVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFL-QD 437
           EL+ +E +Y+  L     V     L  A       A     +FS +  +    ++FL  +
Sbjct: 380 ELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPE 439

Query: 438 LEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARL 497
           LE+R+E +  R+     +L     F ++Y  YV N              + +F  I+  +
Sbjct: 440 LEKRME-EWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEV 498

Query: 498 EESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQEC 557
           ++   C  L L   ++ P QRI R ++L+++ L +   GS D   A K+   +    +  
Sbjct: 499 QKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHS 558

Query: 558 NASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSS 617
           NA+++ M+R  +L+ + + +  E  I   +S  + L++ G +++L+            ++
Sbjct: 559 NAAIRKMERMHKLLKVYELLGGEEDI---VSPTKELIKEGHILKLSAKNG--------TT 607

Query: 618 KAVYLHLFNDCLL--LSRRKELG-KFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLLH 674
           +  YL LFND LL  + R + LG KF+V      A + V  + LK      ++ L +   
Sbjct: 608 QDRYLILFNDRLLYCVPRLRLLGQKFSV-----RARIDVDGMELKES---SNLNLPRTFL 659

Query: 675 GQHMKHQFLLRARTESEKQRWISAL 699
               +    L+ARTE EK+ W+ A+
Sbjct: 660 VSGKQRSLELQARTEEEKKDWVQAI 684


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 80/334 (23%), Positives = 154/334 (46%), Gaps = 28/334 (8%)

Query: 383 ELITSEASYIHSL----SVAVGHFLGSAELSECLGAQDKQWLFSKLPEV-KSTSERFLQD 437
           EL+ +E +Y+  L     V     L +A  S+       + +FS +  + +  S+ FL +
Sbjct: 109 ELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPE 168

Query: 438 LEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARL 497
           L++RL+       + DV+    P F ++Y  YV N             ++P F  +L R+
Sbjct: 169 LQRRLDDWTANPRIGDVIQKLAP-FLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRI 227

Query: 498 EESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQEC 557
           + S     L L   ++ P QRI R ++L++  +++    + D+  A KA + +    Q  
Sbjct: 228 QSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHS 287

Query: 558 NASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSS 617
           NA++  M+R ++L  + +++  E  I   +  +  L+R G +++++     P  +     
Sbjct: 288 NAAITEMERLQDLWEVYQRLGLEDDI---VDPSNTLLREGPVLKISFRRNDPMER----- 339

Query: 618 KAVYLHLFNDCLL--LSRRKELG-KFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLLH 674
              YL LFN+ LL  + R  ++G +F V     +A ++VR+L   +     H FL+    
Sbjct: 340 ---YLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVREL---MDAEFPHSFLV---- 389

Query: 675 GQHMKHQFLLRARTESEKQRWISALCPSSPQEDK 708
               +    L+AR++ E   W+ A   +  Q +K
Sbjct: 390 -SGKQRTLELQARSQEEMISWMQAFQAAIDQIEK 422


>gi|38373682 pleckstrin homology domain containing family G member 5
           isoform a [Homo sapiens]
          Length = 1006

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 25/288 (8%)

Query: 370 LSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLG---SAELSECLGAQDKQWLFSKLPE 426
           L+ R C  QEA +EL+ +EASYI  L V +  FL    + + S  L   + + LFS +PE
Sbjct: 330 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389

Query: 427 VKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRR---VYLPYVTNQAYQE--RTYQ 481
           +     R    +   +     R        D    F+    ++ PY+     +E    Y 
Sbjct: 390 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYM 449

Query: 482 R-LLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540
           R LL +N  F   +   E+ P CQRL L+  L  P QR+T+  +L++++L++T +    E
Sbjct: 450 RGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKE 509

Query: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600
            +      +++  +   NA ++  +  + L  +  +I     +     +   L++    +
Sbjct: 510 AVVA-MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHL 568

Query: 601 EL-APLPAAPPAKL--------------KLSSKAVYLHLFNDCLLLSR 633
           +L AP+P A P +               K S   VY  LF D LL+++
Sbjct: 569 DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 616


>gi|111154084 pleckstrin homology domain containing family G member
           5 isoform b [Homo sapiens]
          Length = 1083

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 25/288 (8%)

Query: 370 LSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLG---SAELSECLGAQDKQWLFSKLPE 426
           L+ R C  QEA +EL+ +EASYI  L V +  FL    + + S  L   + + LFS +PE
Sbjct: 407 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 466

Query: 427 VKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRR---VYLPYVTNQAYQE--RTYQ 481
           +     R    +   +     R        D    F+    ++ PY+     +E    Y 
Sbjct: 467 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYM 526

Query: 482 R-LLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540
           R LL +N  F   +   E+ P CQRL L+  L  P QR+T+  +L++++L++T +    E
Sbjct: 527 RGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKE 586

Query: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600
            +      +++  +   NA ++  +  + L  +  +I     +     +   L++    +
Sbjct: 587 AVVA-MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHL 645

Query: 601 EL-APLPAAPPAKL--------------KLSSKAVYLHLFNDCLLLSR 633
           +L AP+P A P +               K S   VY  LF D LL+++
Sbjct: 646 DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 693


>gi|111154088 pleckstrin homology domain containing family G member
           5 isoform a [Homo sapiens]
          Length = 1006

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 25/288 (8%)

Query: 370 LSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLG---SAELSECLGAQDKQWLFSKLPE 426
           L+ R C  QEA +EL+ +EASYI  L V +  FL    + + S  L   + + LFS +PE
Sbjct: 330 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389

Query: 427 VKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRR---VYLPYVTNQAYQE--RTYQ 481
           +     R    +   +     R        D    F+    ++ PY+     +E    Y 
Sbjct: 390 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYM 449

Query: 482 R-LLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540
           R LL +N  F   +   E+ P CQRL L+  L  P QR+T+  +L++++L++T +    E
Sbjct: 450 RGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKE 509

Query: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600
            +      +++  +   NA ++  +  + L  +  +I     +     +   L++    +
Sbjct: 510 AVVA-MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHL 568

Query: 601 EL-APLPAAPPAKL--------------KLSSKAVYLHLFNDCLLLSR 633
           +L AP+P A P +               K S   VY  LF D LL+++
Sbjct: 569 DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 616


>gi|111154080 pleckstrin homology domain containing family G member
           5 isoform a [Homo sapiens]
          Length = 1006

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 25/288 (8%)

Query: 370 LSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLG---SAELSECLGAQDKQWLFSKLPE 426
           L+ R C  QEA +EL+ +EASYI  L V +  FL    + + S  L   + + LFS +PE
Sbjct: 330 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389

Query: 427 VKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRR---VYLPYVTNQAYQE--RTYQ 481
           +     R    +   +     R        D    F+    ++ PY+     +E    Y 
Sbjct: 390 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYM 449

Query: 482 R-LLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540
           R LL +N  F   +   E+ P CQRL L+  L  P QR+T+  +L++++L++T +    E
Sbjct: 450 RGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKE 509

Query: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600
            +      +++  +   NA ++  +  + L  +  +I     +     +   L++    +
Sbjct: 510 AVVA-MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHL 568

Query: 601 EL-APLPAAPPAKL--------------KLSSKAVYLHLFNDCLLLSR 633
           +L AP+P A P +               K S   VY  LF D LL+++
Sbjct: 569 DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 616


>gi|111154078 pleckstrin homology domain containing family G member
           5 isoform c [Homo sapiens]
          Length = 1062

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 25/288 (8%)

Query: 370 LSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLG---SAELSECLGAQDKQWLFSKLPE 426
           L+ R C  QEA +EL+ +EASYI  L V +  FL    + + S  L   + + LFS +PE
Sbjct: 386 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 445

Query: 427 VKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRR---VYLPYVTNQAYQE--RTYQ 481
           +     R    +   +     R        D    F+    ++ PY+     +E    Y 
Sbjct: 446 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYM 505

Query: 482 R-LLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540
           R LL +N  F   +   E+ P CQRL L+  L  P QR+T+  +L++++L++T +    E
Sbjct: 506 RGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKE 565

Query: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600
            +      +++  +   NA ++  +  + L  +  +I     +     +   L++    +
Sbjct: 566 AVVA-MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHL 624

Query: 601 EL-APLPAAPPAKL--------------KLSSKAVYLHLFNDCLLLSR 633
           +L AP+P A P +               K S   VY  LF D LL+++
Sbjct: 625 DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 672


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 85/362 (23%), Positives = 150/362 (41%), Gaps = 39/362 (10%)

Query: 367  LATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPE 426
            L T+   + K Q    ELI +E  Y+  L + V  F      S  L   +   +F    E
Sbjct: 1173 LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKE 1232

Query: 427  VKSTSERFLQDLEQRLEADVLRFSVCDV--VLDHCPAFRRVYLPYVTNQAYQERTYQRLL 484
            +  ++ + L+ L  R +    +  V  +  +L    +  + Y+ + + Q       Q+  
Sbjct: 1233 LIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKT 1292

Query: 485  LENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMAT 544
             E+  F   L +L   P C+ +PL+SFL+ P QRITR  +L+ +IL+ T +   D     
Sbjct: 1293 DEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLK 1352

Query: 545  KAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQA-------RWLVRHG 597
             A    +EL  + N  V+  + ++ L  +   +  EG    LI  +       R L+  G
Sbjct: 1353 LALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSG 1412

Query: 598  ELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLS 657
            +L +              S+K ++  LFND LLL+    + +FAV   ++       +  
Sbjct: 1413 KLYKTK------------SNKELHGFLFNDFLLLTYM--VKQFAVSSGSEKLFSSKSNAQ 1458

Query: 658  LKLQGIPGHVFLLQLL--------------HGQHMKHQFLLRARTESEKQRWISALCPSS 703
             K+   P  +FL ++L              H  H+   + LR    +E+  W+  +  +S
Sbjct: 1459 FKMYKTP--IFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAAS 1516

Query: 704  PQ 705
             Q
Sbjct: 1517 EQ 1518



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 11/113 (9%)

Query: 673 LHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRT-YKALHP 731
           L  +  + Q  L+     EK +          ++DK+ +   E   +   V   Y+AL+P
Sbjct: 681 LRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYP 740

Query: 732 ------DELTLEKTDILSV--RTWTSDGWLEGVRLADGEKGWVPQAYVEEISS 776
                 DE++    DI+ V  +T    GWL G     G  GW P  YVE++ S
Sbjct: 741 FEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKMPS 791



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 23/86 (26%), Positives = 38/86 (44%), Gaps = 8/86 (9%)

Query: 719 QVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVE-----E 773
           + Q + ++ A   + L   K DI++V     + W   V    G +GW P++YV+     E
Sbjct: 875 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVH---GGRGWFPKSYVKIIPGSE 931

Query: 774 ISSLSARLRNLRENKRVTSATSKLGE 799
           +            NK+ TSA   +GE
Sbjct: 932 VKREEPEALYAAVNKKPTSAAYSVGE 957



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 17/63 (26%), Positives = 30/63 (47%), Gaps = 3/63 (4%)

Query: 721  QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADG---EKGWVPQAYVEEISSL 777
            Q    Y A   ++L+L    ++ +    + GW +G   A G   +KGW P ++V+ +   
Sbjct: 1032 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS 1091

Query: 778  SAR 780
            S R
Sbjct: 1092 SER 1094


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 85/362 (23%), Positives = 150/362 (41%), Gaps = 39/362 (10%)

Query: 367  LATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPE 426
            L T+   + K Q    ELI +E  Y+  L + V  F      S  L   +   +F    E
Sbjct: 1200 LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKE 1259

Query: 427  VKSTSERFLQDLEQRLEADVLRFSVCDV--VLDHCPAFRRVYLPYVTNQAYQERTYQRLL 484
            +  ++ + L+ L  R +    +  V  +  +L    +  + Y+ + + Q       Q+  
Sbjct: 1260 LIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKT 1319

Query: 485  LENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMAT 544
             E+  F   L +L   P C+ +PL+SFL+ P QRITR  +L+ +IL+ T +   D     
Sbjct: 1320 DEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLK 1379

Query: 545  KAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQA-------RWLVRHG 597
             A    +EL  + N  V+  + ++ L  +   +  EG    LI  +       R L+  G
Sbjct: 1380 LALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSG 1439

Query: 598  ELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLS 657
            +L +              S+K ++  LFND LLL+    + +FAV   ++       +  
Sbjct: 1440 KLYKTK------------SNKELHGFLFNDFLLLTYM--VKQFAVSSGSEKLFSSKSNAQ 1485

Query: 658  LKLQGIPGHVFLLQLL--------------HGQHMKHQFLLRARTESEKQRWISALCPSS 703
             K+   P  +FL ++L              H  H+   + LR    +E+  W+  +  +S
Sbjct: 1486 FKMYKTP--IFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAAS 1543

Query: 704  PQ 705
             Q
Sbjct: 1544 EQ 1545



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 11/113 (9%)

Query: 673 LHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRT-YKALHP 731
           L  +  + Q  L+     EK +          ++DK+ +   E   +   V   Y+AL+P
Sbjct: 708 LRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYP 767

Query: 732 ------DELTLEKTDILSV--RTWTSDGWLEGVRLADGEKGWVPQAYVEEISS 776
                 DE++    DI+ V  +T    GWL G     G  GW P  YVE++ S
Sbjct: 768 FEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKMPS 818



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 23/86 (26%), Positives = 38/86 (44%), Gaps = 8/86 (9%)

Query: 719 QVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVE-----E 773
           + Q + ++ A   + L   K DI++V     + W   V    G +GW P++YV+     E
Sbjct: 902 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVH---GGRGWFPKSYVKIIPGSE 958

Query: 774 ISSLSARLRNLRENKRVTSATSKLGE 799
           +            NK+ TSA   +GE
Sbjct: 959 VKREEPEALYAAVNKKPTSAAYSVGE 984



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 17/63 (26%), Positives = 30/63 (47%), Gaps = 3/63 (4%)

Query: 721  QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADG---EKGWVPQAYVEEISSL 777
            Q    Y A   ++L+L    ++ +    + GW +G   A G   +KGW P ++V+ +   
Sbjct: 1059 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS 1118

Query: 778  SAR 780
            S R
Sbjct: 1119 SER 1121


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 73/332 (21%), Positives = 147/332 (44%), Gaps = 32/332 (9%)

Query: 376 KLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGA----QDKQWLFSKLPEVKSTS 431
           KL     EL+ +E +Y+  L     H L     +    A    +    +FS +  +    
Sbjct: 157 KLLHIAQELLHTEETYVKRL-----HLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFH 211

Query: 432 ERFL-QDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRF 490
            +FL  +L+ R+  +         +L     F ++Y  YV N              +P F
Sbjct: 212 GQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLF 271

Query: 491 PGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNAL 550
             ++  +++  VC  L L   ++ P QR+ R ++L+++ LKR  Q + D   A ++   +
Sbjct: 272 KDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELI 331

Query: 551 KELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPP 610
                  NA+++ +++  +L+ + +++  E  I   ++ A  L++ G++ +L+     P 
Sbjct: 332 STAANHSNAAIRKVEKMHKLLEVYEQLGGEEDI---VNPANELIKEGQIQKLSAKNGTPQ 388

Query: 611 AKLKLSSKAVYLHLFNDCLL--LSRRKELG-KFAVFVHAKMAELQVRDLSLKLQGIPGHV 667
            +        +L LFN  +L  + + + +G KF+V     ++ LQV+D+   ++    H 
Sbjct: 389 DR--------HLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDI---VKPNTAHT 437

Query: 668 FLLQLLHGQHMKHQFLLRARTESEKQRWISAL 699
           F++        K    L+ RTE EK+ WI  +
Sbjct: 438 FII-----TGRKRSLELQTRTEEEKKEWIQII 464


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 73/332 (21%), Positives = 147/332 (44%), Gaps = 32/332 (9%)

Query: 376 KLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGA----QDKQWLFSKLPEVKSTS 431
           KL     EL+ +E +Y+  L     H L     +    A    +    +FS +  +    
Sbjct: 157 KLLHIAQELLHTEETYVKRL-----HLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFH 211

Query: 432 ERFL-QDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRF 490
            +FL  +L+ R+  +         +L     F ++Y  YV N              +P F
Sbjct: 212 GQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLF 271

Query: 491 PGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNAL 550
             ++  +++  VC  L L   ++ P QR+ R ++L+++ LKR  Q + D   A ++   +
Sbjct: 272 KDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELI 331

Query: 551 KELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPP 610
                  NA+++ +++  +L+ + +++  E  I   ++ A  L++ G++ +L+     P 
Sbjct: 332 STAANHSNAAIRKVEKMHKLLEVYEQLGGEEDI---VNPANELIKEGQIQKLSAKNGTPQ 388

Query: 611 AKLKLSSKAVYLHLFNDCLL--LSRRKELG-KFAVFVHAKMAELQVRDLSLKLQGIPGHV 667
            +        +L LFN  +L  + + + +G KF+V     ++ LQV+D+   ++    H 
Sbjct: 389 DR--------HLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDI---VKPNTAHT 437

Query: 668 FLLQLLHGQHMKHQFLLRARTESEKQRWISAL 699
           F++        K    L+ RTE EK+ WI  +
Sbjct: 438 FII-----TGRKRSLELQTRTEEEKKEWIQII 464


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 104/431 (24%), Positives = 173/431 (40%), Gaps = 47/431 (10%)

Query: 254  PGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSDV---ASARELRRQ 310
            P D  E D S   +       L  R   E ++SR   N  + +  SDV   A+A   R  
Sbjct: 634  PEDLLESDSSRSEIRLGRSESLKGRE--EMKRSRKAEN--VPRSRSDVDMDAAAEATRLH 689

Query: 311  QREEEGPGDEAEGAEEGPGPP-------RANLSPSSSFRAQ-------RSARGSTFSLWQ 356
            Q         +  + E P PP       R+  SPS  F              G    L  
Sbjct: 690  QSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEP 749

Query: 357  DIPDVR------GSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSE 410
            + PD +      G  V+A L+ R+   QE   EL  +EAS++ +L V    F    +   
Sbjct: 750  E-PDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKEN 808

Query: 411  CLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYV 470
             +  ++   LF  LPE+      + + +++  E   +   + D++L       R  L  V
Sbjct: 809  LMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQV 868

Query: 471  TNQAYQERTYQRLLLE--------NPRFPGILARLEESPVCQRLPLTSFLILPFQRITRL 522
               A Q  +YQ + LE          RF   +   E  P C+RL L   +I   QR+T+ 
Sbjct: 869  ---AAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKY 925

Query: 523  KMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIH---F 579
             +L+E+I+K T  G+ + +   +A +  +E+++  N +V+  +    L    K++     
Sbjct: 926  PLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATAL 985

Query: 580  EGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLH-LFNDCLLLSRRKELG 638
            E    PL ++ + L    +L     +   P        K + LH L  + LL+  +K+  
Sbjct: 986  ERASNPLAAEFKSL----DLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1041

Query: 639  KFAVFVHAKMA 649
            K  +  H+K A
Sbjct: 1042 KLLLKCHSKTA 1052


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 104/431 (24%), Positives = 173/431 (40%), Gaps = 47/431 (10%)

Query: 254  PGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSDV---ASARELRRQ 310
            P D  E D S   +       L  R   E ++SR   N  + +  SDV   A+A   R  
Sbjct: 594  PEDLLESDSSRSEIRLGRSESLKGRE--EMKRSRKAEN--VPRSRSDVDMDAAAEATRLH 649

Query: 311  QREEEGPGDEAEGAEEGPGPP-------RANLSPSSSFRAQ-------RSARGSTFSLWQ 356
            Q         +  + E P PP       R+  SPS  F              G    L  
Sbjct: 650  QSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEP 709

Query: 357  DIPDVR------GSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSE 410
            + PD +      G  V+A L+ R+   QE   EL  +EAS++ +L V    F    +   
Sbjct: 710  E-PDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKEN 768

Query: 411  CLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYV 470
             +  ++   LF  LPE+      + + +++  E   +   + D++L       R  L  V
Sbjct: 769  LMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQV 828

Query: 471  TNQAYQERTYQRLLLE--------NPRFPGILARLEESPVCQRLPLTSFLILPFQRITRL 522
               A Q  +YQ + LE          RF   +   E  P C+RL L   +I   QR+T+ 
Sbjct: 829  ---AAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKY 885

Query: 523  KMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIH---F 579
             +L+E+I+K T  G+ + +   +A +  +E+++  N +V+  +    L    K++     
Sbjct: 886  PLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATAL 945

Query: 580  EGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLH-LFNDCLLLSRRKELG 638
            E    PL ++ + L    +L     +   P        K + LH L  + LL+  +K+  
Sbjct: 946  ERASNPLAAEFKSL----DLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1001

Query: 639  KFAVFVHAKMA 649
            K  +  H+K A
Sbjct: 1002 KLLLKCHSKTA 1012


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 107/443 (24%), Positives = 180/443 (40%), Gaps = 72/443 (16%)

Query: 218 RALISGSGTGAAREGKASGMEARSVEMSGDRVSRPAPGDSREGDWSEP-RLDTQEEPP-- 274
           +A +     GA       GM +R   +        APG    G    P  LD+ +  P  
Sbjct: 303 KAEVDAEKPGATDRKGGVGMPSRDRNIG-------APGQDTPGVSLHPLSLDSPDREPGA 355

Query: 275 -----LGSRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPG 329
                LG  S     Q    L S+   E +D  +       + E   PGDE E     PG
Sbjct: 356 DAPLELGDSSP----QGPMSLESLAPPESTDEGA-------ETESPEPGDEGE-----PG 399

Query: 330 PPRANLSPSSSFRAQRSARGSTFSLWQDI--PDVRGSGVLATLSLRDCKLQEAKFELITS 387
                L P                 W+++  PD      L +L     K QE   EL+ +
Sbjct: 400 RSGLELEPEEP------------PGWRELVPPDT-----LHSLPKSQVKRQEVISELLVT 442

Query: 388 EASYIHSLSVAVGHFLGSAELSECL--GAQDKQWLFSKLPEVKSTSERFLQDL-EQRLEA 444
           EA+++  L V   H L    ++ECL    ++ Q +F  L E+      FL  L ++R E+
Sbjct: 443 EAAHVRMLRVL--HDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 500

Query: 445 DVLRFSVCDVVLDHCPA-----FRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEE 499
             L   + DV+L          F+++   + + Q++     +    ++PRF   +   E 
Sbjct: 501 GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAES 560

Query: 500 SPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNA 559
            P C+RL L   +    QR+T+  +L+++I + T + +E E +   A    +E++   N 
Sbjct: 561 RPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAA-ECCREILHHVNQ 619

Query: 560 SVQSMKRTEELIHLSKKI---HFEGKIFPLISQARWL-VRHGELVELAPLPAAPPAKLKL 615
           +V+ M+    L    +++   H      P++S+ + L +   +LV   PL          
Sbjct: 620 AVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPL-----TWRVT 674

Query: 616 SSKAVYLH--LFNDCLLLSRRKE 636
             KAV +H  L +D LLL +R++
Sbjct: 675 KDKAVEVHVLLLDDLLLLLQRQD 697


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 107/443 (24%), Positives = 180/443 (40%), Gaps = 72/443 (16%)

Query: 218 RALISGSGTGAAREGKASGMEARSVEMSGDRVSRPAPGDSREGDWSEP-RLDTQEEPP-- 274
           +A +     GA       GM +R   +        APG    G    P  LD+ +  P  
Sbjct: 255 KAEVDAEKPGATDRKGGVGMPSRDRNIG-------APGQDTPGVSLHPLSLDSPDREPGA 307

Query: 275 -----LGSRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPG 329
                LG  S     Q    L S+   E +D  +       + E   PGDE E     PG
Sbjct: 308 DAPLELGDSSP----QGPMSLESLAPPESTDEGA-------ETESPEPGDEGE-----PG 351

Query: 330 PPRANLSPSSSFRAQRSARGSTFSLWQDI--PDVRGSGVLATLSLRDCKLQEAKFELITS 387
                L P                 W+++  PD      L +L     K QE   EL+ +
Sbjct: 352 RSGLELEPEEP------------PGWRELVPPDT-----LHSLPKSQVKRQEVISELLVT 394

Query: 388 EASYIHSLSVAVGHFLGSAELSECL--GAQDKQWLFSKLPEVKSTSERFLQDL-EQRLEA 444
           EA+++  L V   H L    ++ECL    ++ Q +F  L E+      FL  L ++R E+
Sbjct: 395 EAAHVRMLRVL--HDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452

Query: 445 DVLRFSVCDVVLDHCPA-----FRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEE 499
             L   + DV+L          F+++   + + Q++     +    ++PRF   +   E 
Sbjct: 453 GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAES 512

Query: 500 SPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNA 559
            P C+RL L   +    QR+T+  +L+++I + T + +E E +   A    +E++   N 
Sbjct: 513 RPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAA-ECCREILHHVNQ 571

Query: 560 SVQSMKRTEELIHLSKKI---HFEGKIFPLISQARWL-VRHGELVELAPLPAAPPAKLKL 615
           +V+ M+    L    +++   H      P++S+ + L +   +LV   PL          
Sbjct: 572 AVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPL-----TWRVT 626

Query: 616 SSKAVYLH--LFNDCLLLSRRKE 636
             KAV +H  L +D LLL +R++
Sbjct: 627 KDKAVEVHVLLLDDLLLLLQRQD 649


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 107/443 (24%), Positives = 180/443 (40%), Gaps = 72/443 (16%)

Query: 218 RALISGSGTGAAREGKASGMEARSVEMSGDRVSRPAPGDSREGDWSEP-RLDTQEEPP-- 274
           +A +     GA       GM +R   +        APG    G    P  LD+ +  P  
Sbjct: 288 KAEVDAEKPGATDRKGGVGMPSRDRNIG-------APGQDTPGVSLHPLSLDSPDREPGA 340

Query: 275 -----LGSRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPG 329
                LG  S     Q    L S+   E +D  +       + E   PGDE E     PG
Sbjct: 341 DAPLELGDSSP----QGPMSLESLAPPESTDEGA-------ETESPEPGDEGE-----PG 384

Query: 330 PPRANLSPSSSFRAQRSARGSTFSLWQDI--PDVRGSGVLATLSLRDCKLQEAKFELITS 387
                L P                 W+++  PD      L +L     K QE   EL+ +
Sbjct: 385 RSGLELEPEEP------------PGWRELVPPDT-----LHSLPKSQVKRQEVISELLVT 427

Query: 388 EASYIHSLSVAVGHFLGSAELSECL--GAQDKQWLFSKLPEVKSTSERFLQDL-EQRLEA 444
           EA+++  L V   H L    ++ECL    ++ Q +F  L E+      FL  L ++R E+
Sbjct: 428 EAAHVRMLRVL--HDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 485

Query: 445 DVLRFSVCDVVLDHCPA-----FRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEE 499
             L   + DV+L          F+++   + + Q++     +    ++PRF   +   E 
Sbjct: 486 GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAES 545

Query: 500 SPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNA 559
            P C+RL L   +    QR+T+  +L+++I + T + +E E +   A    +E++   N 
Sbjct: 546 RPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAA-ECCREILHHVNQ 604

Query: 560 SVQSMKRTEELIHLSKKI---HFEGKIFPLISQARWL-VRHGELVELAPLPAAPPAKLKL 615
           +V+ M+    L    +++   H      P++S+ + L +   +LV   PL          
Sbjct: 605 AVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPL-----TWRVT 659

Query: 616 SSKAVYLH--LFNDCLLLSRRKE 636
             KAV +H  L +D LLL +R++
Sbjct: 660 KDKAVEVHVLLLDDLLLLLQRQD 682


>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
           [Homo sapiens]
          Length = 532

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 78/311 (25%), Positives = 127/311 (40%), Gaps = 37/311 (11%)

Query: 328 PGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITS 387
           P P   N +PSS+ R           LW +  DV  + +L +   ++ K QEA FEL   
Sbjct: 90  PRPWSRNAAPSSTKRRDSK-------LWSETFDVCVNQMLTS---KEIKRQEAIFELSQG 139

Query: 388 EASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVL 447
           E   I  L +A   +         +  Q+   +F  L  +    E  L  L    + D  
Sbjct: 140 EEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS 199

Query: 448 RFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLP 507
              V  +++   P     Y  Y +NQ   +        ++ R    L R  ESP  ++L 
Sbjct: 200 TEHVGPILVGWLPCLSS-YDSYCSNQVAAKALLDHKKQDH-RVQDFLQRCLESPFSRKLD 257

Query: 508 LTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASV---QSM 564
           L +FL +P  R+ +  +L+  IL+ T   + D+    +A N ++ +V E N      +  
Sbjct: 258 LWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECR 317

Query: 565 KRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLH- 623
              E L++L      EG+   LI  +R L  HGEL                +++ V LH 
Sbjct: 318 YYKERLLYLE-----EGQKDSLIDSSRVLCCHGEL---------------KNNRGVKLHV 357

Query: 624 -LFNDCLLLSR 633
            LF + L+++R
Sbjct: 358 FLFQEVLVITR 368


>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
           [Homo sapiens]
          Length = 558

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 78/311 (25%), Positives = 127/311 (40%), Gaps = 37/311 (11%)

Query: 328 PGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITS 387
           P P   N +PSS+ R           LW +  DV  + +L +   ++ K QEA FEL   
Sbjct: 116 PRPWSRNAAPSSTKRRDSK-------LWSETFDVCVNQMLTS---KEIKRQEAIFELSQG 165

Query: 388 EASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVL 447
           E   I  L +A   +         +  Q+   +F  L  +    E  L  L    + D  
Sbjct: 166 EEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS 225

Query: 448 RFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLP 507
              V  +++   P     Y  Y +NQ   +        ++ R    L R  ESP  ++L 
Sbjct: 226 TEHVGPILVGWLPCLSS-YDSYCSNQVAAKALLDHKKQDH-RVQDFLQRCLESPFSRKLD 283

Query: 508 LTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASV---QSM 564
           L +FL +P  R+ +  +L+  IL+ T   + D+    +A N ++ +V E N      +  
Sbjct: 284 LWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECR 343

Query: 565 KRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLH- 623
              E L++L      EG+   LI  +R L  HGEL                +++ V LH 
Sbjct: 344 YYKERLLYLE-----EGQKDSLIDSSRVLCCHGEL---------------KNNRGVKLHV 383

Query: 624 -LFNDCLLLSR 633
            LF + L+++R
Sbjct: 384 FLFQEVLVITR 394


>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
           sapiens]
          Length = 526

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 78/311 (25%), Positives = 127/311 (40%), Gaps = 37/311 (11%)

Query: 328 PGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITS 387
           P P   N +PSS+ R           LW +  DV  + +L +   ++ K QEA FEL   
Sbjct: 84  PRPWSRNAAPSSTKRRDSK-------LWSETFDVCVNQMLTS---KEIKRQEAIFELSQG 133

Query: 388 EASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVL 447
           E   I  L +A   +         +  Q+   +F  L  +    E  L  L    + D  
Sbjct: 134 EEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS 193

Query: 448 RFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLP 507
              V  +++   P     Y  Y +NQ   +        ++ R    L R  ESP  ++L 
Sbjct: 194 TEHVGPILVGWLPCLSS-YDSYCSNQVAAKALLDHKKQDH-RVQDFLQRCLESPFSRKLD 251

Query: 508 LTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASV---QSM 564
           L +FL +P  R+ +  +L+  IL+ T   + D+    +A N ++ +V E N      +  
Sbjct: 252 LWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECR 311

Query: 565 KRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLH- 623
              E L++L      EG+   LI  +R L  HGEL                +++ V LH 
Sbjct: 312 YYKERLLYLE-----EGQKDSLIDSSRVLCCHGEL---------------KNNRGVKLHV 351

Query: 624 -LFNDCLLLSR 633
            LF + L+++R
Sbjct: 352 FLFQEVLVITR 362


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 70/331 (21%), Positives = 150/331 (45%), Gaps = 27/331 (8%)

Query: 376 KLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLG---AQDKQWLFSKLPEVKSTSE 432
           KL +   EL+ +E +Y++ L +    F          G   A+    +FS +  + +   
Sbjct: 206 KLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHS 265

Query: 433 RFL-QDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFP 491
           +FL  +LE+R++       + D++    P F ++Y  YV          + +    P+F 
Sbjct: 266 KFLLPELEKRMQEWETTPRIGDILQKLAP-FLKMYGEYVKGFDNAMELVKNMTERIPQFK 324

Query: 492 GILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALK 551
            ++  +++  +C  L L   ++ P QRI R +ML+++ L++    S D + A K+   + 
Sbjct: 325 SVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIIS 384

Query: 552 ELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPA 611
                 N++++ M+  ++L+ + + +   G+   +++ +  L++ G++++L        A
Sbjct: 385 TAASHSNSAIRKMENLKKLLEIYEML---GEEEDIVNPSNELIKEGQILKL--------A 433

Query: 612 KLKLSSKAVYLHLFNDCLLLSRRKEL---GKFAVFVHAKMAELQVRDLSLKLQGIPGHVF 668
               S++  YL LFN+ LL    K      KF V     +  +++  +  + +  P H F
Sbjct: 434 ARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKI--VETQNEEYP-HTF 490

Query: 669 LLQLLHGQHMKHQFLLRARTESEKQRWISAL 699
            +        +    L+A +  +K+ WI AL
Sbjct: 491 QV-----SGKERTLELQASSAQDKEEWIKAL 516


>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
           [Homo sapiens]
          Length = 596

 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 74/325 (22%), Positives = 135/325 (41%), Gaps = 28/325 (8%)

Query: 338 SSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSV 397
           SS       A+  + +LW ++ D+    +  +L+ R+ + QEA +E+   E   I  L +
Sbjct: 139 SSRSTVPTPAKRRSSALWSEMLDIT---MKESLTTREIRRQEAIYEMSRGEQDLIEDLKL 195

Query: 398 AVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLD 457
           A   +         +  ++   +F  L       E  L  + +  + D     +  +++ 
Sbjct: 196 ARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVS 255

Query: 458 HCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQ 517
             P     Y  Y +NQ   +    +   ++PR    L R  ESP  ++L L SFL +P  
Sbjct: 256 WLPRLN-AYRGYCSNQLAAKALLDQKK-QDPRVQDFLQRCLESPFSRKLDLWSFLDIPRS 313

Query: 518 RITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKI 577
           R+ +  +L++ ILK T +   D  +   A   ++ ++ + N      K   E  +   K+
Sbjct: 314 RLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLK----KGESECQYYIDKL 369

Query: 578 HF--EGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSR-- 633
            +  E +  P I  ++ L+ HGEL                S   +Y+ LF D L+L+R  
Sbjct: 370 EYLDEKQRDPRIEASKVLLCHGEL-------------RSKSGHKLYIFLFQDILVLTRPV 416

Query: 634 -RKELGKFAVFVH-AKMAELQVRDL 656
            R E   + V+     + EL + DL
Sbjct: 417 TRNERHSYQVYRQPIPVQELVLEDL 441


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,548,816
Number of Sequences: 37866
Number of extensions: 1798330
Number of successful extensions: 8884
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 8294
Number of HSP's gapped (non-prelim): 740
length of query: 802
length of database: 18,247,518
effective HSP length: 110
effective length of query: 692
effective length of database: 14,082,258
effective search space: 9744922536
effective search space used: 9744922536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.