Search of human proteins with 40254992

Search of human proteins with 40254992

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40254992 carbonic reductase 4 [Homo sapiens]
         (237 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40254992 carbonic reductase 4 [Homo sapiens]                       463   e-131
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]          129   2e-30
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...   118   5e-27
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...   112   2e-25
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...   112   4e-25
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...   109   2e-24
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]    107   9e-24
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ...   102   4e-22
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    99   2e-21
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...    96   3e-20
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     96   3e-20
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                 92   5e-19
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    91   7e-19
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    90   2e-18
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]        85   5e-17
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                    83   2e-16
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    82   5e-16
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    81   7e-16
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     80   2e-15
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        80   2e-15
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              79   4e-15
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           78   8e-15
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    78   8e-15
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    75   5e-14
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...    75   6e-14
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          75   6e-14
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         70   2e-12
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    70   2e-12
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            69   4e-12
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    69   5e-12

>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score =  463 bits (1191), Expect = e-131
 Identities = 237/237 (100%), Positives = 237/237 (100%)

Query: 1   MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKE 60
           MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKE
Sbjct: 1   MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKE 60

Query: 61  HDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMR 120
           HDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMR
Sbjct: 61  HDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMR 120

Query: 121 TMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF 180
           TMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF
Sbjct: 121 TMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF 180

Query: 181 VHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 237
           VHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL
Sbjct: 181 VHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 237


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score =  129 bits (324), Expect = 2e-30
 Identities = 85/244 (34%), Positives = 131/244 (53%), Gaps = 17/244 (6%)

Query: 7   VFGGSRGIGRAVAQLMARKGYRLAVI----------ARNLEGAKAAAGDLGGDHLAFSCD 56
           V G   GIGRAV+  +A +G  +A             R L G  +  G   G+H AF  D
Sbjct: 16  VTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQAD 75

Query: 57  VAKEHDVQNTFEELEKHLGRV-NFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTC 115
           V++    +   E+++    R  + +V+ AGI +D  L+    +D    +  NL G+ L  
Sbjct: 76  VSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVT 135

Query: 116 KAAMRTMIQQQ-GGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVN 174
           +AA + ++     GSI+N+ SIVG  GN GQ+ Y+ASK G++G ++  A+E+ R  IR N
Sbjct: 136 QAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCN 195

Query: 175 VVAPGFVHTDMTKDLKE---EHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVV 229
            V PGF+ T MT+ + +   + + + IP+G  G+  +VA  V FL   +S YITG  + V
Sbjct: 196 SVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEV 255

Query: 230 DGGL 233
            GGL
Sbjct: 256 TGGL 259


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score =  118 bits (295), Expect = 5e-27
 Identities = 79/248 (31%), Positives = 124/248 (50%), Gaps = 16/248 (6%)

Query: 4   VCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDV 63
           V  + GG+ G+G A A+ +  +G    ++     G +A A  LG + +    DV  E DV
Sbjct: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDV 71

Query: 64  QNTFEELEKHLGRVNFLVNAAGI---NRDGLLVRTKT---EDMVSQLHTNLLGSMLTCKA 117
           Q      +   GRV+  VN AGI   ++   L + +T   ED    L  NL+G+    + 
Sbjct: 72  QTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRL 131

Query: 118 AMRTMIQQ------QGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKI 171
               M Q       Q G I+N  S+   +G  GQ+ YSASKGG+VG +  +A+++A   I
Sbjct: 132 VAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGI 191

Query: 172 RVNVVAPGFVHTDMTKDLKEE---HLKKNIPL-GRFGETIEVAHAVVFLLESPYITGHVL 227
           RV  +APG   T +   L E+    L   +P   R G+  E AH V  ++E+P++ G V+
Sbjct: 192 RVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVI 251

Query: 228 VVDGGLQL 235
            +DG +++
Sbjct: 252 RLDGAIRM 259


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score =  112 bits (281), Expect = 2e-25
 Identities = 80/242 (33%), Positives = 125/242 (51%), Gaps = 11/242 (4%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58
           +KV  V   + GIG A+A+ +A+ G  + V +R  +    A   L G+ L+ +   C V 
Sbjct: 32  NKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVG 91

Query: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQ-LHTNLLGSMLTCKA 117
           K  D +       K  G ++ LV+ A +N     +   TE++  + L  N+    L  KA
Sbjct: 92  KAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKA 151

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
            +  M ++ GGS+V V SI     + G S Y+ SK  L+G ++ LA E+A + IRVN +A
Sbjct: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLA 211

Query: 178 PGFVHTDMTKDL-----KEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVD 230
           PG + T  ++ L     KEE +K+ + + R GE  + A  V FL   ++ YITG  +VV 
Sbjct: 212 PGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVG 271

Query: 231 GG 232
           GG
Sbjct: 272 GG 273


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score =  112 bits (279), Expect = 4e-25
 Identities = 75/245 (30%), Positives = 125/245 (51%), Gaps = 23/245 (9%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDH-----LAFSCDV 57
           KV  V G ++GIGRA A+ +  KG ++A++  NLE        L         L   CDV
Sbjct: 6   KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65

Query: 58  AKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
           A +  +++TF ++  H GR++ LVN AG+N +    +T   ++VS +    LG       
Sbjct: 66  ADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLG-----LD 120

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSR--ALAKEVARKKIRVNV 175
            M      +GG I+N+ S+ GL   + Q VY ASK G+VGF+R  ALA  +    +R+N 
Sbjct: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA 180

Query: 176 VAPGFVHTDMTKDLKEE-----------HLKKNIPLGRFGETIEVAHAVVFLLESPYITG 224
           + PGFV+T + + +++E           H+K  I      +   +A+ ++ L+E   + G
Sbjct: 181 ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG 240

Query: 225 HVLVV 229
            ++ +
Sbjct: 241 AIMKI 245


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score =  109 bits (273), Expect = 2e-24
 Identities = 78/246 (31%), Positives = 125/246 (50%), Gaps = 17/246 (6%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
           KV  V GG RGIG  + +     G R+ +  ++  G +A   +L G  +   CDV +E D
Sbjct: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGA-VFILCDVTQEDD 68

Query: 63  VQNTFEELEKHLGRVNFLVNAAGINRDGLLVR-TKTEDMVSQLHTNLLGSMLTCKAAMRT 121
           V+    E  +  GR++ +VN AG +        T  +     L  NLLG+    K A+  
Sbjct: 69  VKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPY 128

Query: 122 MIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 181
           + + QG +++N+ S+VG  G +    Y A+KG +   ++ALA + +   +RVN ++PG +
Sbjct: 129 LRKSQG-NVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNI 187

Query: 182 HTDMTKDL-----------KEEHLKKNIPLGRFGETIEVAHAVVFLL-ESPYITGHVLVV 229
            T + ++L           +E  L +  PLGR G+  EV  A VFL  E+ + TG  L+V
Sbjct: 188 WTPLWEELAALMPDPRATIREGMLAQ--PLGRMGQPAEVGAAAVFLASEANFCTGIELLV 245

Query: 230 DGGLQL 235
            GG +L
Sbjct: 246 TGGAEL 251


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score =  107 bits (267), Expect = 9e-24
 Identities = 79/252 (31%), Positives = 125/252 (49%), Gaps = 22/252 (8%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGD--------HLAFS 54
           +V  V GG+ GIG+A+ + +   G  + + +R LE  K+AA +L  +         +   
Sbjct: 19  QVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQ 78

Query: 55  CDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLT 114
           C++  E +V N  +      G++NFLVN  G           ++   + L TNL G+   
Sbjct: 79  CNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYM 138

Query: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYS-ASKGGLVGFSRALAKEVARKKIRV 173
           CKA   + +++ GGSIVN+  IV  K     +V+S A++ G+   +++LA E A   IR+
Sbjct: 139 CKAVYSSWMKEHGGSIVNI--IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRI 196

Query: 174 NVVAPGFVHTDMT--------KDLKEEHLKKNIPLGRFGETIEVAHAVVFLLE--SPYIT 223
           N VAPG +++           +   E   +K IP  R G   EV+  V FLL   + +IT
Sbjct: 197 NCVAPGVIYSQTAVENYGSWGQSFFEGSFQK-IPAKRIGVPEEVSSVVCFLLSPAASFIT 255

Query: 224 GHVLVVDGGLQL 235
           G  + VDGG  L
Sbjct: 256 GQSVDVDGGRSL 267


>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
           [Homo sapiens]
          Length = 252

 Score =  102 bits (253), Expect = 4e-22
 Identities = 74/248 (29%), Positives = 118/248 (47%), Gaps = 25/248 (10%)

Query: 4   VCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDV 63
           V  + GG+ G+G A A+ +  +G    ++     G +A A  LG + +    DV  E DV
Sbjct: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDV 71

Query: 64  QNTFEELEKHLGRVNFLVNAAGI---NRDGLLVRTKT---EDMVSQLHTNLLGSMLTCKA 117
           Q      +   GRV+  VN AGI   ++   L + +T   ED    L  NL+G+    + 
Sbjct: 72  QTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRL 131

Query: 118 AMRTMIQQ------QGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKI 171
               M Q       Q G I+N  S+   +G  GQ+ YSASKGG+VG +  +A+++A    
Sbjct: 132 VAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA---- 187

Query: 172 RVNVVAPGFVHTDMTKDLKEE---HLKKNIPL-GRFGETIEVAHAVVFLLESPYITGHVL 227
                  G   T +   L E+    L   +P   R G+  E AH V  ++E+P++ G V+
Sbjct: 188 -----PIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVI 242

Query: 228 VVDGGLQL 235
            +DG +++
Sbjct: 243 RLDGAIRM 250


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 99.4 bits (246), Expect = 2e-21
 Identities = 74/241 (30%), Positives = 119/241 (49%), Gaps = 12/241 (4%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58
           ++V  V G + GIG A+A+ +AR G  + + +R  +    A   L G+ L+ +   C V 
Sbjct: 36  NRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVG 95

Query: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINR-DGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
           K  D +    +  +H G V+FLV +AG+N   G  + T  +     L  N+    L    
Sbjct: 96  KAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQ 155

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
            +  M + + G+++ V SI          VY+ SK  L+G +R LA E+A K IRVN V 
Sbjct: 156 LLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVV 214

Query: 178 PGFVHTDMTK-----DLKEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVD 230
           PG + TD +K     +   ++ K++  L R GE+ + A  V FL   ++ Y+ G  + V 
Sbjct: 215 PGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVA 274

Query: 231 G 231
           G
Sbjct: 275 G 275


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score = 95.9 bits (237), Expect = 3e-20
 Identities = 75/245 (30%), Positives = 119/245 (48%), Gaps = 14/245 (5%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58
           +KV  V   +  IG AVAQ +A+ G  + V  R  +    A   L G+ L+ +   C V 
Sbjct: 32  NKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVG 91

Query: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGL----LVRTKTEDMVSQLHTNLLGSMLT 114
           K  D +       K  G ++ L  +   ++ GL    L++T  E     L  N     L 
Sbjct: 92  KMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALM 151

Query: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVN 174
            KA +  M ++ GGS+  + S+   +   G S Y+ SK  L+G ++ LA E+A + IRVN
Sbjct: 152 IKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIRVN 211

Query: 175 VVAPGFVHTDMTKDL-----KEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVL 227
            +APG + T  ++ L     KEE +K+ + + R GE  +    V FL   ++ Y+TG  +
Sbjct: 212 CLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDASYLTGETV 271

Query: 228 VVDGG 232
           +V GG
Sbjct: 272 MVGGG 276


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 95.9 bits (237), Expect = 3e-20
 Identities = 70/246 (28%), Positives = 123/246 (50%), Gaps = 20/246 (8%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
           KV  +   ++GIG+A A   AR+G +  VIA ++  +K    +          DV K+  
Sbjct: 7   KVIILTAAAQGIGQAAALAFAREGAK--VIATDINESKLQELEKYPGIQTRVLDVTKKKQ 64

Query: 63  VQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM 122
           +     E+E    R++ L N AG    G ++  + +D    ++ N+    L  KA +  M
Sbjct: 65  IDQFANEVE----RLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKM 120

Query: 123 IQQQGGSIVNVGSIVG-LKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 181
           + Q+ G+I+N+ S+   +KG   + VYS +K  ++G ++++A +  ++ IR N V PG V
Sbjct: 121 LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV 180

Query: 182 HTDM----------TKDLKEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVV 229
            T             ++ + + LK+    GRF    E+A   V+L   ES Y+TG+ +++
Sbjct: 181 DTPSLQERIQARGNPEEARNDFLKRQ-KTGRFATAEEIAMLCVYLASDESAYVTGNPVII 239

Query: 230 DGGLQL 235
           DGG  L
Sbjct: 240 DGGWSL 245


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score = 91.7 bits (226), Expect = 5e-19
 Identities = 72/246 (29%), Positives = 113/246 (45%), Gaps = 12/246 (4%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLE----GAKAAAGDLGGDHLAFSCDV 57
           DKV  + GG  GIG  +A++  R G    + +R+L      A+  AG  G   L  S DV
Sbjct: 28  DKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDV 87

Query: 58  AKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
                V    ++  K  GR++ L+N A  N              + +  +  G+    + 
Sbjct: 88  RAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRV 147

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
                 +  GG IVN+ + +G +G + Q    ++K  +   +R LA E   + IRVN +A
Sbjct: 148 LYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLA 207

Query: 178 PGFVH-TDMTKDL--KEEHLKKNI---PLGRFGETIEVAHAVVFLLE--SPYITGHVLVV 229
           PG +  T+  + L   +  L   +   PL R G   E+AH+V++L    + Y+TG VLV 
Sbjct: 208 PGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVA 267

Query: 230 DGGLQL 235
           DGG  L
Sbjct: 268 DGGAWL 273


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 91.3 bits (225), Expect = 7e-19
 Identities = 58/169 (34%), Positives = 89/169 (52%), Gaps = 10/169 (5%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDH-----LAFSCDV 57
           KV  V G ++GIGRA A+ +  KG ++A++  NLE        L         L   CDV
Sbjct: 6   KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65

Query: 58  AKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
           A +  +++TF ++  H GR++ LVN AG+N +    +T   ++VS +    LG       
Sbjct: 66  ADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLG-----LD 120

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEV 166
            M      +GG I+N+ S+ GL   + Q VY ASK G+VGF+R+ A  +
Sbjct: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTI 169


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 61/190 (32%), Positives = 95/190 (50%), Gaps = 5/190 (2%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58
           ++V  V G + GIG A+A+ +AR G  + + +R  +    A   L G+ L+ +   C V 
Sbjct: 36  NRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVG 95

Query: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINR-DGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
           K  D +    +  +H G V+FLV +AG+N   G  + T  +     L  N+    L    
Sbjct: 96  KAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQ 155

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
            +  M + + G+++ V SI          VY+ SK  L+G +R LA E+A K IRVN V 
Sbjct: 156 LLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVV 214

Query: 178 PGFVHTDMTK 187
           PG + TD +K
Sbjct: 215 PGIIKTDFSK 224


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score = 85.1 bits (209), Expect = 5e-17
 Identities = 73/250 (29%), Positives = 118/250 (47%), Gaps = 17/250 (6%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDL----GGDHLAFSCDVA 58
           KV  + GG  G+G+ +  L++  G +  + +R ++  KA A  +    G    A  CDV 
Sbjct: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119

Query: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGS-MLTCKA 117
               VQNT  EL K  G  N ++N A  N      R       +     L G+  +T + 
Sbjct: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEI 179

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSAS-KGGLVGFSRALAKEVARKKIRVNVV 176
             + +  Q+G + +++ +I    G SG  V SAS K G+   S++LA E  +  +R NV+
Sbjct: 180 GKQLIKAQKGAAFLSITTIYAETG-SGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238

Query: 177 APG-------FVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLE--SPYITGHVL 227
            PG       F   D T   ++E + + IP GR G   E+A+   FL    + +I G V+
Sbjct: 239 QPGPIKTKGAFSRLDPTGTFEKEMIGR-IPCGRLGTVEELANLAAFLCSDYASWINGAVI 297

Query: 228 VVDGGLQLIL 237
             DGG ++++
Sbjct: 298 KFDGGEEVLI 307


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score = 83.2 bits (204), Expect = 2e-16
 Identities = 66/214 (30%), Positives = 94/214 (43%), Gaps = 31/214 (14%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAV-----------------IARNLEGAKAAAGD 45
           +VC + G   G+GR  A   AR+   L +                 I R+LE A AAA  
Sbjct: 37  QVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQ 96

Query: 46  LGGDH-----------LAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVR 94
            G                ++CDV K  +V  T E + K +G V+ LVN AG+     L+ 
Sbjct: 97  AGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLE 156

Query: 95  TKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGG 154
              E +   +  N      T KA + TM++   G IV V S +GL   +G   Y ASK G
Sbjct: 157 CPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFG 216

Query: 155 LVGFSRALAKEV---ARKKIRVNVVAPGFVHTDM 185
           +VGF  +L+ E+    +  I+  +V P  V T M
Sbjct: 217 VVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 81.6 bits (200), Expect = 5e-16
 Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 6/192 (3%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGD---LGGDHLAFSCDVAK 59
           ++  + G   GIGR      A++   L +   N  G +  A +   LG    A+  D + 
Sbjct: 37  EIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSN 96

Query: 60  EHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAM 119
             ++  +  +++K +G V  +VN AG      L+ TK E++      N+LG     KA +
Sbjct: 97  REEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALL 156

Query: 120 RTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKE---VARKKIRVNVV 176
            +M+++  G IV V S+ G +G      Y +SK   VGF R L  E   + +  I+ + +
Sbjct: 157 PSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCL 216

Query: 177 APGFVHTDMTKD 188
            P FV+T  TK+
Sbjct: 217 CPVFVNTGFTKN 228


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 81.3 bits (199), Expect = 7e-16
 Identities = 60/198 (30%), Positives = 97/198 (48%), Gaps = 14/198 (7%)

Query: 7   VFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDH-------LAFSCDVAK 59
           V GGS GIG+ +A    ++G  + ++ARN +    A  ++           L  S DV++
Sbjct: 37  VTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQ 96

Query: 60  EHD-VQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAA 118
           +++ V+N  ++ ++ LG V+ LVN AG+   G     +       +  N LGS+   +A 
Sbjct: 97  DYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAV 156

Query: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVV-- 176
           + TM +++ G IV V S  G  G  G + YSASK  + G + AL  EV    + + V   
Sbjct: 157 ITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216

Query: 177 ----APGFVHTDMTKDLK 190
                PGF   + TK L+
Sbjct: 217 PDTDTPGFAEENRTKPLE 234


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 66/202 (32%), Positives = 91/202 (45%), Gaps = 13/202 (6%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
           +V  V G   G+GRA A   A +G  + V     +      G L  D +           
Sbjct: 10  RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA 69

Query: 63  VQN--TFEELEKHL-------GRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSML 113
           V N  + EE EK +       GR++ +VN AGI RD    R   ED       +L GS  
Sbjct: 70  VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQ 129

Query: 114 TCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRV 173
             +AA   M +Q+ G I+   S  G+ GN GQ+ YSA+K GL+G + +LA E  +  I  
Sbjct: 130 VTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHC 189

Query: 174 NVVAPG----FVHTDMTKDLKE 191
           N +AP        T M +DL E
Sbjct: 190 NTIAPNAGSRMTQTVMPEDLVE 211


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 63/243 (25%), Positives = 115/243 (47%), Gaps = 17/243 (6%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIAR---NLEGAKAAAGDLG--GDHLAFSCD 56
           D++  V G S GIG AVA+ + ++G ++   AR   N+E   A     G  G  + + CD
Sbjct: 11  DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70

Query: 57  VAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCK 116
           ++ E D+ + F  +      V+  +N AG+ R   L+   T       + N+L   +  +
Sbjct: 71  LSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTR 130

Query: 117 AAMRTMIQQ--QGGSIVNVGSIVG--LKGNSGQSVYSASKGGLVGFSRALAKEV--ARKK 170
            A ++M ++    G I+N+ S+ G  +   S    YSA+K  +   +  L +E+  A+  
Sbjct: 131 EAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTH 190

Query: 171 IRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETI---EVAHAVVFLLESPYITGHVL 227
           IR   ++PG V T     L ++  +K        + +   +VA AV+++L +P    H+ 
Sbjct: 191 IRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTP---AHIQ 247

Query: 228 VVD 230
           + D
Sbjct: 248 IGD 250


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 78.6 bits (192), Expect = 4e-15
 Identities = 73/238 (30%), Positives = 105/238 (44%), Gaps = 21/238 (8%)

Query: 7   VFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQ-N 65
           V G  +GIGR   Q +   G R+  ++R          DL  D L   C   +   V   
Sbjct: 12  VTGAGKGIGRGTVQALHATGARVVAVSRT-------QADL--DSLVRECPGIEPVCVDLG 62

Query: 66  TFEELEKHLGRV---NFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM 122
            +E  E+ LG V   + LVN A +      +    E        NL   +   +   R +
Sbjct: 63  DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122

Query: 123 IQQQ-GGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 181
           I +   G+IVNV S    +  +  SVY ++KG L   ++ +A E+   KIRVN V P  V
Sbjct: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182

Query: 182 HTDM-----TKDLKEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVDGG 232
            T M     +   K + +   IPLG+F E   V +A++FLL   S   TG  L V+GG
Sbjct: 183 MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 77.8 bits (190), Expect = 8e-15
 Identities = 55/190 (28%), Positives = 90/190 (47%), Gaps = 7/190 (3%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAA---AGDLGGDHL-AFSCDVA 58
           ++  + G   G+GR +A   AR G  L +   N EG +     A + G   + A++CD +
Sbjct: 41  EIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCS 100

Query: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAA 118
           ++  V    ++++K +G V+ L+N AGI      +    E M      N    + T KA 
Sbjct: 101 QKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAF 160

Query: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEV---ARKKIRVNV 175
           +  MI    G +V + S  GL G +G + Y ASK    GF+ ++  E     +K I+  +
Sbjct: 161 LPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTI 220

Query: 176 VAPGFVHTDM 185
           V P F+ T M
Sbjct: 221 VCPFFIKTGM 230


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 77.8 bits (190), Expect = 8e-15
 Identities = 51/192 (26%), Positives = 91/192 (47%), Gaps = 9/192 (4%)

Query: 4   VCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLA---------FS 54
           V  + G + G+G+  A++    G +L +  RN    +    +L   H            +
Sbjct: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113

Query: 55  CDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLT 114
            D+     +     E+ +  G V+ LVN AGI+  G ++ T  +     + TN  G +  
Sbjct: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173

Query: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVN 174
            KA + +MI+++ G IV + SI G      +S Y+ASK     F   L  E+ + +I V 
Sbjct: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVT 233

Query: 175 VVAPGFVHTDMT 186
           V++PG++HT+++
Sbjct: 234 VISPGYIHTNLS 245


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 75.1 bits (183), Expect = 5e-14
 Identities = 58/190 (30%), Positives = 91/190 (47%), Gaps = 9/190 (4%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58
           +KV  V   + GIG A+A+ +A+    + V +R  +    A   L G+ L+ +   C V 
Sbjct: 32  NKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVG 91

Query: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRD-GLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
           K  D +       K  G ++ LV+ A +N   G L+    E     L  N+    L  KA
Sbjct: 92  KAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKA 151

Query: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
            +  M ++ GGS+V V SI     + G S Y+ SK  L+G +  LA E+A + IRVN   
Sbjct: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNC-- 209

Query: 178 PGFVHTDMTK 187
              +H D+++
Sbjct: 210 ---LHLDLSR 216


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score = 74.7 bits (182), Expect = 6e-14
 Identities = 61/234 (26%), Positives = 102/234 (43%), Gaps = 15/234 (6%)

Query: 7   VFGGSRGIGRAVAQLMARKGYRLAVI----ARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
           + GG RGIGR +A+  A +G R  V+     + L+        +G +   F CDV    +
Sbjct: 43  ITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREE 102

Query: 63  VQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM 122
           V  T + + + +G +  LVN A +     L+ +  + ++   H N LG   T KA +  M
Sbjct: 103 VYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRM 162

Query: 123 IQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVAR-KKIRVNVVAPGFV 181
           ++ Q G IV + S++ L    G   Y  SK     F  +L   +     +    V P   
Sbjct: 163 LELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHT 222

Query: 182 HTDMTKDLKEEH------LKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVV 229
            T+M + ++         LK      R  E +++  A++ L   P+ T H LV+
Sbjct: 223 STEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLL---PW-TMHALVI 272


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 74.7 bits (182), Expect = 6e-14
 Identities = 60/185 (32%), Positives = 95/185 (51%), Gaps = 10/185 (5%)

Query: 7   VFGGSRGIGRAVAQLMA---RKGYRLAVIARNL---EGAKAAAGDLGGDHLAFS-CDVAK 59
           + G S GIG  +A  +A   +K Y++    R+L   E  +AAAG+  G  L  +  DV  
Sbjct: 10  ISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVCS 69

Query: 60  EHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAM 119
           +  V      ++   G V+ LVN AG+   G L       M +   TN  G++   KA +
Sbjct: 70  DESVAQCLSCIQ---GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVL 126

Query: 120 RTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPG 179
             M +++ G IV + S++GL+G     VY+ASK  L GF  +LA ++ +  I +++V PG
Sbjct: 127 PGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPG 186

Query: 180 FVHTD 184
            V T+
Sbjct: 187 PVVTE 191


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 6/192 (3%)

Query: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGD---LGGDHLAFSCDVAK 59
           ++  + G   GIGR  A   A+   +L +   N  G +  A     LG     F  D + 
Sbjct: 37  EIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSN 96

Query: 60  EHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAM 119
             D+ ++ ++++  +G V+ LVN AG+     L  T+   +      N+L    T KA +
Sbjct: 97  REDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFL 156

Query: 120 RTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKI---RVNVV 176
             M +   G IV V S  G         Y +SK   VGF + L  E+A  +I   +   +
Sbjct: 157 PAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCL 216

Query: 177 APGFVHTDMTKD 188
            P FV+T   K+
Sbjct: 217 CPNFVNTGFIKN 228


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 53/188 (28%), Positives = 89/188 (47%), Gaps = 5/188 (2%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEH 61
           DK   + G   G G  +A+ +  +G R+       +GA+   G         + DV K  
Sbjct: 29  DKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKME 88

Query: 62  DVQNTFEELEKHLGRVNF--LVNAAGINRDGLLVR-TKTEDMVSQLHTNLLGSMLTCKAA 118
            +    + +++H+G      LVN AGI     L     TED ++ L  NL+G ++    +
Sbjct: 89  SIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIG-VIQVTLS 147

Query: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAP 178
           M  ++++  G IVNV SI+G +       Y  SK G+  FS  L +E+    +++++V P
Sbjct: 148 MLPLVRRARGRIVNVSSILG-RVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEP 206

Query: 179 GFVHTDMT 186
           G+  T MT
Sbjct: 207 GYFRTGMT 214


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 68.9 bits (167), Expect = 4e-12
 Identities = 55/204 (26%), Positives = 99/204 (48%), Gaps = 12/204 (5%)

Query: 1   MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDL----GGDHLAFSCD 56
           M +   + G   GIG+A +  +A++G  + +I+R LE  +A A ++    G        D
Sbjct: 47  MGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQAD 106

Query: 57  VAKEHDVQNTFEELEKHLG--RVNFLVNAAGINRDGLLVR--TKTEDMVSQLHTNLLGSM 112
             K+    + +E +++ L    +  LVN  G+  + L        +++ S +H N+   +
Sbjct: 107 FTKD----DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVV 162

Query: 113 LTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIR 172
              +  ++ M  +Q G I+N+ S + L      S+YSASK  +  FS+AL +E   K++ 
Sbjct: 163 KMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVI 222

Query: 173 VNVVAPGFVHTDMTKDLKEEHLKK 196
           + V+ P  V T MTK L    + K
Sbjct: 223 IQVLTPYAVSTAMTKYLNTNVITK 246


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 68.6 bits (166), Expect = 5e-12
 Identities = 58/205 (28%), Positives = 94/205 (45%), Gaps = 8/205 (3%)

Query: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARN---LEGAKAAAGDLGG----DHLAFS 54
           D V  V G S GIG  +A  +++ G  L + AR    LE  K    + G     D L   
Sbjct: 50  DMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLP 109

Query: 55  CDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLT 114
            D+      +   + + +  GR++ LVN  G+++  L + T  +     +  N LG++  
Sbjct: 110 LDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSL 169

Query: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVAR-KKIRV 173
            K  +  MI+++ G IV V SI+G+        Y ASK  L GF   L  E+A    I V
Sbjct: 170 TKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIV 229

Query: 174 NVVAPGFVHTDMTKDLKEEHLKKNI 198
           + + PG V +++ ++     + K I
Sbjct: 230 SNICPGPVQSNIVENSLAGEVTKTI 254


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,724,817
Number of Sequences: 37866
Number of extensions: 295036
Number of successful extensions: 845
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 717
Number of HSP's gapped (non-prelim): 82
length of query: 237
length of database: 18,247,518
effective HSP length: 99
effective length of query: 138
effective length of database: 14,498,784
effective search space: 2000832192
effective search space used: 2000832192
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.