Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 40254464

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40254464 leptin receptor isoform 1 [Homo sapiens]
         (1165 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40254464 leptin receptor isoform 1 [Homo sapiens]                 2413   0.0  
gi|51093381 leptin receptor isoform 3 [Homo sapiens]                 1863   0.0  
gi|51093379 leptin receptor isoform 2 [Homo sapiens]                 1863   0.0  
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ...   103   1e-21
gi|27437045 colony stimulating factor 3 receptor isoform d precu...    80   1e-14
gi|24496783 colony stimulating factor 3 receptor isoform c precu...    80   1e-14
gi|27437042 colony stimulating factor 3 receptor isoform b precu...    80   1e-14
gi|4503081 colony stimulating factor 3 receptor isoform a precur...    80   1e-14
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s...    74   6e-13
gi|189083786 leukemia inhibitory factor receptor precursor [Homo...    74   6e-13
gi|115430248 gp130-like monocyte receptor [Homo sapiens]               67   8e-11
gi|4557040 oncostatin M receptor [Homo sapiens]                        62   2e-09
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ...    62   3e-09
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]    61   7e-09
gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]      58   5e-08
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]              56   2e-07
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom...    53   1e-06
gi|31083174 interleukin 21 receptor precursor [Homo sapiens]           51   6e-06
gi|11141869 interleukin 21 receptor precursor [Homo sapiens]           51   6e-06
gi|31083180 interleukin 21 receptor precursor [Homo sapiens]           51   6e-06
gi|4506107 prolactin receptor [Homo sapiens]                           45   4e-04
gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor ...    44   0.001
gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor [...    44   0.001
gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [H...    44   0.001
gi|4885491 myeloproliferative leukemia virus oncogene precursor ...    41   0.006
gi|10834992 interleukin 13 receptor, alpha 2 precursor [Homo sap...    41   0.006
gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo sapi...    41   0.008
gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo sap...    41   0.008
gi|24430212 interleukin 23 receptor precursor [Homo sapiens]           40   0.013
gi|4559408 colony stimulating factor 2 receptor, beta precursor ...    40   0.013

>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
          Length = 1165

 Score = 2413 bits (6254), Expect = 0.0
 Identities = 1165/1165 (100%), Positives = 1165/1165 (100%)

Query: 1    MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS 60
            MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
Sbjct: 1    MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS 60

Query: 61   NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF 120
            NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
Sbjct: 61   NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF 120

Query: 121  QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS 180
            QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
Sbjct: 121  QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS 180

Query: 181  FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP 240
            FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
Sbjct: 181  FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP 240

Query: 241  LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP 300
            LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
Sbjct: 241  LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP 300

Query: 301  GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI 360
            GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
Sbjct: 301  GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI 360

Query: 361  VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH 420
            VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
Sbjct: 361  VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH 420

Query: 421  RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH 480
            RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
Sbjct: 421  RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH 480

Query: 481  PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP 540
            PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
Sbjct: 481  PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP 540

Query: 541  SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV 600
            SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
Sbjct: 541  SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV 600

Query: 601  PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV 660
            PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
Sbjct: 601  PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV 660

Query: 661  TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI 720
            TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
Sbjct: 661  TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI 720

Query: 721  GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED 780
            GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
Sbjct: 721  GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED 780

Query: 781  GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA 840
            GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
Sbjct: 781  GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA 840

Query: 841  GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI 900
            GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
Sbjct: 841  GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI 900

Query: 901  KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN 960
            KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
Sbjct: 901  KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN 960

Query: 961  SVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPL 1020
            SVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPL
Sbjct: 961  SVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPL 1020

Query: 1021 KDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYL 1080
            KDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYL
Sbjct: 1021 KDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYL 1080

Query: 1081 GVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFAS 1140
            GVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFAS
Sbjct: 1081 GVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFAS 1140

Query: 1141 YMPQFQTCSTQTHKIMENKMCDLTV 1165
            YMPQFQTCSTQTHKIMENKMCDLTV
Sbjct: 1141 YMPQFQTCSTQTHKIMENKMCDLTV 1165


>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
          Length = 958

 Score = 1863 bits (4826), Expect = 0.0
 Identities = 891/891 (100%), Positives = 891/891 (100%)

Query: 1   MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS 60
           MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
Sbjct: 1   MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS 60

Query: 61  NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF 120
           NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
Sbjct: 61  NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF 120

Query: 121 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS 180
           QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
Sbjct: 121 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS 180

Query: 181 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP 240
           FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
Sbjct: 181 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP 240

Query: 241 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP 300
           LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
Sbjct: 241 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP 300

Query: 301 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI 360
           GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
Sbjct: 301 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI 360

Query: 361 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH 420
           VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
Sbjct: 361 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH 420

Query: 421 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH 480
           RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
Sbjct: 421 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH 480

Query: 481 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP 540
           PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
Sbjct: 481 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP 540

Query: 541 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV 600
           SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
Sbjct: 541 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV 600

Query: 601 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV 660
           PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
Sbjct: 601 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV 660

Query: 661 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI 720
           TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
Sbjct: 661 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI 720

Query: 721 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED 780
           GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
Sbjct: 721 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED 780

Query: 781 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA 840
           GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
Sbjct: 781 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA 840

Query: 841 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQK 891
           GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQK
Sbjct: 841 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQK 891


>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
          Length = 896

 Score = 1863 bits (4826), Expect = 0.0
 Identities = 891/891 (100%), Positives = 891/891 (100%)

Query: 1   MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS 60
           MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
Sbjct: 1   MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS 60

Query: 61  NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF 120
           NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
Sbjct: 61  NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF 120

Query: 121 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS 180
           QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
Sbjct: 121 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS 180

Query: 181 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP 240
           FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
Sbjct: 181 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP 240

Query: 241 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP 300
           LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
Sbjct: 241 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP 300

Query: 301 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI 360
           GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
Sbjct: 301 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI 360

Query: 361 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH 420
           VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
Sbjct: 361 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH 420

Query: 421 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH 480
           RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
Sbjct: 421 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH 480

Query: 481 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP 540
           PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
Sbjct: 481 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP 540

Query: 541 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV 600
           SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
Sbjct: 541 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV 600

Query: 601 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV 660
           PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
Sbjct: 601 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV 660

Query: 661 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI 720
           TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
Sbjct: 661 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI 720

Query: 721 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED 780
           GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
Sbjct: 721 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED 780

Query: 781 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA 840
           GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
Sbjct: 781 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA 840

Query: 841 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQK 891
           GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQK
Sbjct: 841 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQK 891


>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
           [Homo sapiens]
          Length = 918

 Score =  103 bits (257), Expect = 1e-21
 Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%)

Query: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91

Query: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143

Query: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190

Query: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249

Query: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308

Query: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680
           YWS+WS  A  +  + + P + P FW  I+    +  + V L+WK L   ++   +  Y 
Sbjct: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367

Query: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740
           +   T           N TK T   T   +  T+   N +G S A      +      + 
Sbjct: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426

Query: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798
           V  L A+P   + + V W       K   +I+EW  L++       W +   +V + Y+ 
Sbjct: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483

Query: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828
            +    + Y  ++ P++ +G G P+ I ++
Sbjct: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258

Query: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314


>gi|27437045 colony stimulating factor 3 receptor isoform d
           precursor [Homo sapiens]
          Length = 783

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 111/531 (20%), Positives = 206/531 (38%), Gaps = 59/531 (11%)

Query: 341 LTSVGSNVSFHCIYKKE-NKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSK--VTFFNLN 397
           +  +G  ++  CI K+  + + P  +I+W +  AE  P  +   +SD   +  +T  +LN
Sbjct: 35  IVHLGDPITASCIIKQNCSHLDPEPQILWRLG-AELQPGGRQQRLSDGTQESIITLPHLN 93

Query: 398 ETKPRGKFTYDAVYCCNEHECHHRYAELYVID-----------VNINISCETDGYLTKMT 446
            T+        A   C    C +    L ++D           +  N+SC  +   + + 
Sbjct: 94  HTQ--------AFLSC----CLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLI 141

Query: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIF--QPIF 504
           C+W       L  S   L+  +S   C             DC +  DG   C    + + 
Sbjct: 142 CQWEPGPETHLPTS-FTLKSFKSRGNCQTQGD-----SILDC-VPKDGQSHCCIPRKHLL 194

Query: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP-----SSVKAEITINIGLLKISWE 559
           L     +W++  ++LG+  SP  C+ P  VVK  PP                G L++ WE
Sbjct: 195 LYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE 254

Query: 560 KPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLD 617
            P  P    N + ++R+     E  W +      ++    L        Y +Q+RC R  
Sbjct: 255 -PWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWP 313

Query: 618 GLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQ 677
             G+WS+WS        +    +R   +WR          + V L WKP+   +    +Q
Sbjct: 314 LPGHWSDWSPSLELRTTERAPTVRLDTWWR----QRQLDPRTVQLFWKPVPLEEDSGRIQ 369

Query: 678 RYVINHHTSCNGTWSEDVGNHTKF--TFLWTEQAHTVTVLAINSIGASVANFNLTFSWPM 735
            YV++   S        + N T+   TF    +A  V ++A NS G S     + FS   
Sbjct: 370 GYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT-PVVFS--E 426

Query: 736 SKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEW----KNLNEDGEIKWLRISSS 791
           S+   +  L A   +   + V W   P +     ++IEW     + +   +   +  +  
Sbjct: 427 SRGPALTRLHAMARDPHSLWVGW--EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGR 484

Query: 792 VKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGL 842
              + + ++  P + Y+  + P++ + +G  + + +++Q+    H  +  L
Sbjct: 485 ATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHL 535



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 30/113 (26%), Positives = 55/113 (48%), Gaps = 17/113 (15%)

Query: 224 SPLMSVQPINMVKPDPPLGLHMEITDD------GNLKISWSSPPLVP-------FPLQYQ 270
           SP + + P+++VK +PP+   M+ + +      G L++ W   P  P         L+++
Sbjct: 214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE--PWQPGLHINQKCELRHK 271

Query: 271 VKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
            +  E S  ++      + A    +  +LP ++Y +Q+R  R   PG WSDWS
Sbjct: 272 PQRGEASWALVGPLP--LEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|24496783 colony stimulating factor 3 receptor isoform c
           precursor [Homo sapiens]
          Length = 863

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 111/531 (20%), Positives = 206/531 (38%), Gaps = 59/531 (11%)

Query: 341 LTSVGSNVSFHCIYKKE-NKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSK--VTFFNLN 397
           +  +G  ++  CI K+  + + P  +I+W +  AE  P  +   +SD   +  +T  +LN
Sbjct: 35  IVHLGDPITASCIIKQNCSHLDPEPQILWRLG-AELQPGGRQQRLSDGTQESIITLPHLN 93

Query: 398 ETKPRGKFTYDAVYCCNEHECHHRYAELYVID-----------VNINISCETDGYLTKMT 446
            T+        A   C    C +    L ++D           +  N+SC  +   + + 
Sbjct: 94  HTQ--------AFLSC----CLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLI 141

Query: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIF--QPIF 504
           C+W       L  S   L+  +S   C             DC +  DG   C    + + 
Sbjct: 142 CQWEPGPETHLPTS-FTLKSFKSRGNCQTQGD-----SILDC-VPKDGQSHCCIPRKHLL 194

Query: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP-----SSVKAEITINIGLLKISWE 559
           L     +W++  ++LG+  SP  C+ P  VVK  PP                G L++ WE
Sbjct: 195 LYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE 254

Query: 560 KPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLD 617
            P  P    N + ++R+     E  W +      ++    L        Y +Q+RC R  
Sbjct: 255 -PWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWP 313

Query: 618 GLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQ 677
             G+WS+WS        +    +R   +WR          + V L WKP+   +    +Q
Sbjct: 314 LPGHWSDWSPSLELRTTERAPTVRLDTWWR----QRQLDPRTVQLFWKPVPLEEDSGRIQ 369

Query: 678 RYVINHHTSCNGTWSEDVGNHTKF--TFLWTEQAHTVTVLAINSIGASVANFNLTFSWPM 735
            YV++   S        + N T+   TF    +A  V ++A NS G S     + FS   
Sbjct: 370 GYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT-PVVFS--E 426

Query: 736 SKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEW----KNLNEDGEIKWLRISSS 791
           S+   +  L A   +   + V W   P +     ++IEW     + +   +   +  +  
Sbjct: 427 SRGPALTRLHAMARDPHSLWVGW--EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGR 484

Query: 792 VKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGL 842
              + + ++  P + Y+  + P++ + +G  + + +++Q+    H  +  L
Sbjct: 485 ATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHL 535



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 30/113 (26%), Positives = 55/113 (48%), Gaps = 17/113 (15%)

Query: 224 SPLMSVQPINMVKPDPPLGLHMEITDD------GNLKISWSSPPLVP-------FPLQYQ 270
           SP + + P+++VK +PP+   M+ + +      G L++ W   P  P         L+++
Sbjct: 214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE--PWQPGLHINQKCELRHK 271

Query: 271 VKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
            +  E S  ++      + A    +  +LP ++Y +Q+R  R   PG WSDWS
Sbjct: 272 PQRGEASWALVGPLP--LEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|27437042 colony stimulating factor 3 receptor isoform b
           precursor [Homo sapiens]
          Length = 769

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 111/531 (20%), Positives = 206/531 (38%), Gaps = 59/531 (11%)

Query: 341 LTSVGSNVSFHCIYKKE-NKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSK--VTFFNLN 397
           +  +G  ++  CI K+  + + P  +I+W +  AE  P  +   +SD   +  +T  +LN
Sbjct: 35  IVHLGDPITASCIIKQNCSHLDPEPQILWRLG-AELQPGGRQQRLSDGTQESIITLPHLN 93

Query: 398 ETKPRGKFTYDAVYCCNEHECHHRYAELYVID-----------VNINISCETDGYLTKMT 446
            T+        A   C    C +    L ++D           +  N+SC  +   + + 
Sbjct: 94  HTQ--------AFLSC----CLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLI 141

Query: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIF--QPIF 504
           C+W       L  S   L+  +S   C             DC +  DG   C    + + 
Sbjct: 142 CQWEPGPETHLPTS-FTLKSFKSRGNCQTQGD-----SILDC-VPKDGQSHCCIPRKHLL 194

Query: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP-----SSVKAEITINIGLLKISWE 559
           L     +W++  ++LG+  SP  C+ P  VVK  PP                G L++ WE
Sbjct: 195 LYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE 254

Query: 560 KPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLD 617
            P  P    N + ++R+     E  W +      ++    L        Y +Q+RC R  
Sbjct: 255 -PWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWP 313

Query: 618 GLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQ 677
             G+WS+WS        +    +R   +WR          + V L WKP+   +    +Q
Sbjct: 314 LPGHWSDWSPSLELRTTERAPTVRLDTWWR----QRQLDPRTVQLFWKPVPLEEDSGRIQ 369

Query: 678 RYVINHHTSCNGTWSEDVGNHTKF--TFLWTEQAHTVTVLAINSIGASVANFNLTFSWPM 735
            YV++   S        + N T+   TF    +A  V ++A NS G S     + FS   
Sbjct: 370 GYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT-PVVFS--E 426

Query: 736 SKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEW----KNLNEDGEIKWLRISSS 791
           S+   +  L A   +   + V W   P +     ++IEW     + +   +   +  +  
Sbjct: 427 SRGPALTRLHAMARDPHSLWVGW--EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGR 484

Query: 792 VKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGL 842
              + + ++  P + Y+  + P++ + +G  + + +++Q+    H  +  L
Sbjct: 485 ATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHL 535



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 30/113 (26%), Positives = 55/113 (48%), Gaps = 17/113 (15%)

Query: 224 SPLMSVQPINMVKPDPPLGLHMEITDD------GNLKISWSSPPLVP-------FPLQYQ 270
           SP + + P+++VK +PP+   M+ + +      G L++ W   P  P         L+++
Sbjct: 214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE--PWQPGLHINQKCELRHK 271

Query: 271 VKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
            +  E S  ++      + A    +  +LP ++Y +Q+R  R   PG WSDWS
Sbjct: 272 PQRGEASWALVGPLP--LEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
           [Homo sapiens]
          Length = 836

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 111/531 (20%), Positives = 206/531 (38%), Gaps = 59/531 (11%)

Query: 341 LTSVGSNVSFHCIYKKE-NKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSK--VTFFNLN 397
           +  +G  ++  CI K+  + + P  +I+W +  AE  P  +   +SD   +  +T  +LN
Sbjct: 35  IVHLGDPITASCIIKQNCSHLDPEPQILWRLG-AELQPGGRQQRLSDGTQESIITLPHLN 93

Query: 398 ETKPRGKFTYDAVYCCNEHECHHRYAELYVID-----------VNINISCETDGYLTKMT 446
            T+        A   C    C +    L ++D           +  N+SC  +   + + 
Sbjct: 94  HTQ--------AFLSC----CLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLI 141

Query: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIF--QPIF 504
           C+W       L  S   L+  +S   C             DC +  DG   C    + + 
Sbjct: 142 CQWEPGPETHLPTS-FTLKSFKSRGNCQTQGD-----SILDC-VPKDGQSHCCIPRKHLL 194

Query: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP-----SSVKAEITINIGLLKISWE 559
           L     +W++  ++LG+  SP  C+ P  VVK  PP                G L++ WE
Sbjct: 195 LYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE 254

Query: 560 KPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLD 617
            P  P    N + ++R+     E  W +      ++    L        Y +Q+RC R  
Sbjct: 255 -PWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWP 313

Query: 618 GLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQ 677
             G+WS+WS        +    +R   +WR          + V L WKP+   +    +Q
Sbjct: 314 LPGHWSDWSPSLELRTTERAPTVRLDTWWR----QRQLDPRTVQLFWKPVPLEEDSGRIQ 369

Query: 678 RYVINHHTSCNGTWSEDVGNHTKF--TFLWTEQAHTVTVLAINSIGASVANFNLTFSWPM 735
            YV++   S        + N T+   TF    +A  V ++A NS G S     + FS   
Sbjct: 370 GYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT-PVVFS--E 426

Query: 736 SKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEW----KNLNEDGEIKWLRISSS 791
           S+   +  L A   +   + V W   P +     ++IEW     + +   +   +  +  
Sbjct: 427 SRGPALTRLHAMARDPHSLWVGW--EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGR 484

Query: 792 VKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGL 842
              + + ++  P + Y+  + P++ + +G  + + +++Q+    H  +  L
Sbjct: 485 ATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHL 535



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 30/113 (26%), Positives = 55/113 (48%), Gaps = 17/113 (15%)

Query: 224 SPLMSVQPINMVKPDPPLGLHMEITDD------GNLKISWSSPPLVP-------FPLQYQ 270
           SP + + P+++VK +PP+   M+ + +      G L++ W   P  P         L+++
Sbjct: 214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE--PWQPGLHINQKCELRHK 271

Query: 271 VKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
            +  E S  ++      + A    +  +LP ++Y +Q+R  R   PG WSDWS
Sbjct: 272 PQRGEASWALVGPLP--LEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)

Query: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375
           WSDWS  +  +         FP   +  VGS+++F C+   + K++ +  ++   N    
Sbjct: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287

Query: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435
            P    D   ++V+ +   N++ +   G    + V+   ++         Y  D    ++
Sbjct: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340

Query: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495
           CET   L ++ C W+   + +L          R++ Y             K     ++  
Sbjct: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392

Query: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
           Y+ +FQ +     Y   +  ++ LG   S     + + V  P  P+S K +  IN   +K
Sbjct: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450

Query: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612
           +SW  P  F + N   +I    S    + +   +   ++ S  V+L   +   +Y  ++R
Sbjct: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510

Query: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672
           C   +    WS WSN    +  +   P +GP+ WR  + D     KN+ + WKPL  N++
Sbjct: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564

Query: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727
                  +++++ SC+      + SE      K      +  + ++V+A NS+G+S  + 
Sbjct: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620

Query: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785
             +   P   + I Q +         ++++W   P+      ++I+W N   +E   + W
Sbjct: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674

Query: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812
            ++ S+S +     D F P  +Y F LY
Sbjct: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 13/78 (16%)

Query: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873
           GVG  K +   T+++        GL +  ++PV ++  + ++ ++L   +R  +K+ F+ 
Sbjct: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871

Query: 874 DVPNPKNCSWAQGLNFQK 891
           D+PNP+NC   + L FQK
Sbjct: 872 DIPNPENC---KALQFQK 886


>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)

Query: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375
           WSDWS  +  +         FP   +  VGS+++F C+   + K++ +  ++   N    
Sbjct: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287

Query: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435
            P    D   ++V+ +   N++ +   G    + V+   ++         Y  D    ++
Sbjct: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340

Query: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495
           CET   L ++ C W+   + +L          R++ Y             K     ++  
Sbjct: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392

Query: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
           Y+ +FQ +     Y   +  ++ LG   S     + + V  P  P+S K +  IN   +K
Sbjct: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450

Query: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612
           +SW  P  F + N   +I    S    + +   +   ++ S  V+L   +   +Y  ++R
Sbjct: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510

Query: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672
           C   +    WS WSN    +  +   P +GP+ WR  + D     KN+ + WKPL  N++
Sbjct: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564

Query: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727
                  +++++ SC+      + SE      K      +  + ++V+A NS+G+S  + 
Sbjct: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620

Query: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785
             +   P   + I Q +         ++++W   P+      ++I+W N   +E   + W
Sbjct: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674

Query: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812
            ++ S+S +     D F P  +Y F LY
Sbjct: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 13/78 (16%)

Query: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873
           GVG  K +   T+++        GL +  ++PV ++  + ++ ++L   +R  +K+ F+ 
Sbjct: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871

Query: 874 DVPNPKNCSWAQGLNFQK 891
           D+PNP+NC   + L FQK
Sbjct: 872 DIPNPENC---KALQFQK 886


>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
          Length = 764

 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 43/419 (10%)

Query: 433 NISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
           NISC    Y   +TC WS     S  + T++  Y     + +   +         C    
Sbjct: 59  NISC-VYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASC---- 113

Query: 493 DGFYECIFQP-IFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINI 551
                  F P I +   YT+ +   +  G + S  T    +++ K  PP   + +  + I
Sbjct: 114 -----SFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168

Query: 552 G-LLKISWEKPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAV 606
             +++I W KP      ++L++ +R+         ++    + K K+ +  +  L     
Sbjct: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE 228

Query: 607 YAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKP 666
           Y + +RC   +   +WS+WS     +  + + P  G E WR++        + V LLWK 
Sbjct: 229 YVIALRCAVKESK-FWSDWSQEKMGMTEE-EAPC-GLELWRVLKPAEADGRRPVRLLWKK 285

Query: 667 LMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTE-QAHTVTVLAINSIGASVA 725
                 L     Y I ++   N   +E +    +   L    ++  V++++ NS+G S  
Sbjct: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKS-- 343

Query: 726 NFNLTFSWPMSKVNIV----QSLSAYPLNSSCV-----IVSWILSPSDYKLMYFIIEW-- 774
                   P++ + I     +S     +  +CV     +V W  S  D     ++IEW  
Sbjct: 344 --------PVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNT--WMIEWFP 393

Query: 775 KNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDI 833
              +E   + W  +S +       D   P   Y  S+YP+  + VG+P  I ++ ++ +
Sbjct: 394 DVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGV 452



 Score = 31.6 bits (70), Expect = 4.6
 Identities = 45/224 (20%), Positives = 91/224 (40%), Gaps = 20/224 (8%)

Query: 127 WNIQCWLKGDL-KLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPL---VPQKGSFQ 182
           W    W+   L K  +  + +  +N+   Y Y+ +L        E S     V +  +F 
Sbjct: 35  WTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFG 94

Query: 183 MVHCNCSVHEC-----CECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP 237
             H NC+ +         C   +P   + D   + ++  +G  + +S +   +  N+ K 
Sbjct: 95  EKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKT 154

Query: 238 DPPLGLHME--ITDDGNLKISWSSPPLVPFP--LQYQVKYSENSTTVIREAD-----KIV 288
           +PP    ++  +     ++I W  P L P    L+Y +++   ++T   E +     K  
Sbjct: 155 EPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDK 214

Query: 289 SATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQD 332
           + T  L   + P + Y + +R    +    WSDWS  ++  T++
Sbjct: 215 NQTYNLT-GLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEE 256


>gi|4557040 oncostatin M receptor [Homo sapiens]
          Length = 979

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 113/517 (21%), Positives = 198/517 (38%), Gaps = 60/517 (11%)

Query: 316 PGIWSDWSTPRVFTTQD------VIYFPPKILTSVGSNVSFHCIYKK-ENKIVPSKEIVW 368
           P  WS+WS+    + QD      +  FP   L   G+NV+   + +  +N +    E   
Sbjct: 126 PNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLE--- 182

Query: 369 WMNLAEKIPQSQYDVVSDHVSKVTFFNLNETK-PRGKFTYDAVYC-CNEHECHHRYAELY 426
                ++I   Q D        VT FNLN     R K T   +YC  ++         + 
Sbjct: 183 ----GKQIHGEQLD------PHVTAFNLNSVPFIRNKGTN--IYCEASQGNVSEGMKGIV 230

Query: 427 -----VIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHP 481
                V++   + SCET+ + T + C W   T  +L  S    + +  +L+ S       
Sbjct: 231 LFVSKVLEEPKDFSCETEDFKT-LHCTWDPGTDTALGWSKQPSQSY--TLFESFSGEKKL 287

Query: 482 ISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPS 541
            +    C  Q     +  +    +   Y     +N                  V  + P 
Sbjct: 288 CTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHR----------VYLMNPF 337

Query: 542 SVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVP 601
           SV  E  +N     ++W+      NN  +  +  L G E +   Y V    +    L   
Sbjct: 338 SVNFE-NVNATNAIMTWKVHSI-RNNFTYLCQIELHG-EGKMMQYNVSIKVNGEYFLSEL 394

Query: 602 DLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVT 661
           +    Y  +VRC        WS WS   +T +     P   P+ WRI++ +       VT
Sbjct: 395 EPATEYMARVRCADASHFWKWSEWSGQNFTTLE--AAPSEAPDVWRIVSLE--PGNHTVT 450

Query: 662 LLWKPLMKNDSLCSVQRY--VINHHTSCNGTWSEDVGNHTKFTFLWTEQ-AHTVTVLAIN 718
           L WKPL K  +   +  Y  V+ +    + +    +      T L  ++ ++ + V+A N
Sbjct: 451 LFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANN 510

Query: 719 SIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLN 778
           S+GAS A+  +  + P +K    + ++      S   +SW   P D  ++ ++++W +  
Sbjct: 511 SVGASPASVIVISADPENKEVEEERIAGTEGGFS---LSWKPQPGD--VIGYVVDWCDHT 565

Query: 779 ED--GEIKWLRISSSVKKYYIH-DHFIPIEKYQFSLY 812
           +D  G+ +W  +  +     I  D F P  +Y F +Y
Sbjct: 566 QDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIY 602


>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
           [Homo sapiens]
          Length = 329

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 72/309 (23%), Positives = 122/309 (39%), Gaps = 40/309 (12%)

Query: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91

Query: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143

Query: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190

Query: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249

Query: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308

Query: 621 YWSNWSNPA 629
           YWS+WS  A
Sbjct: 309 YWSDWSEEA 317



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258

Query: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314


>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
          Length = 862

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 88/409 (21%), Positives = 159/409 (38%), Gaps = 38/409 (9%)

Query: 412 CCNEHECHHRYAELYV---IDVNINISCETDGYLTKMTCRWSTSTIQSL-AESTLQLRYH 467
           C N  E     AE++V    +   N+SC   G    + C W       L  E TLQL   
Sbjct: 105 CINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGP 164

Query: 468 RSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPT 527
           ++  +      I+       C     G       P    S +T  +   +SLGS  S P+
Sbjct: 165 KNLTWQKQCKDIY-------CDYLDFGIN---LTPESPESNFTAKVTAVNSLGSSSSLPS 214

Query: 528 CVLPDSVVKPLPPSSVKAEI-TINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMY 586
                 +V+PLPP  ++ +    ++    + W        N   ++RY  S   + W M 
Sbjct: 215 TFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLN---RLRYRPSNSRL-WNMV 270

Query: 587 EVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFW 646
            V  AK +   L +      Y  Q+  K     G WS+WS        + + P    + W
Sbjct: 271 NVTKAKGRHDLLDLKPF-TEYEFQISSKLHLYKGSWSDWSESLRAQTPE-EEPTGMLDVW 328

Query: 647 RIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNG-TWSEDVGNHTKFTFLW 705
            +       +++ ++L WK L  +++   +  Y +       G   ++++  HT +T + 
Sbjct: 329 YMKRHIDYSRQQ-ISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVI 387

Query: 706 TEQAH-TVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSD 764
               +  V V A NS G+S+       +   + +   + +SA       ++V+W     D
Sbjct: 388 PRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKD 447

Query: 765 -YKLMYFIIEWKNLNEDGE----IKWLR---------ISSSVKKYYIHD 799
              +  +++EW+ L+  G+    + WLR         IS ++K Y  ++
Sbjct: 448 PSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYE 496


>gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]
          Length = 229

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 32/101 (31%), Positives = 49/101 (48%), Gaps = 5/101 (4%)

Query: 233 NMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFP----LQYQVKYSENSTTVIREADKIV 288
           +++KPDPP G+ +    +  L++ W  P   PFP    L+Y ++Y             I 
Sbjct: 125 HIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPI- 183

Query: 289 SATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFT 329
            ATS ++ ++ P + Y VQV  + L   G  SDWS P   T
Sbjct: 184 EATSFILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATAT 224



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 38/131 (29%), Positives = 60/131 (45%), Gaps = 9/131 (6%)

Query: 503 IFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKP- 561
           +F ++ Y + +   H  GS  S     + + ++KP PP  V+    +    L++ WE P 
Sbjct: 96  LFSMAPYVLNVTAVHPWGS-SSSFVPFITEHIIKPDPPEGVRLS-PLAERQLQVQWEPPG 153

Query: 562 --VFPEN-NLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDG 618
              FPE  +L++ IRY   G     + + V   ++ S  L      A Y VQV  + L  
Sbjct: 154 SWPFPEIFSLKYWIRYKRQGAA---RFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTD 210

Query: 619 LGYWSNWSNPA 629
            G  S+WS PA
Sbjct: 211 YGELSDWSLPA 221


>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
          Length = 422

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 72/304 (23%), Positives = 121/304 (39%), Gaps = 41/304 (13%)

Query: 344 VGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRG 403
           +GS++   C    +     ++ + W +N   ++P     V++     +   NLN ++ R 
Sbjct: 52  IGSSLLATCSVHGDPPGATAEGLYWTLN-GRRLPPELSRVLNASTLALALANLNGSRQRS 110

Query: 404 KFTYDAVYCCNEHECHHRYAELYV---IDVNINISCETDGYLTKMTCRWSTST-----IQ 455
               D + C          + LYV    +  +NISC +   +  +TCRW+        + 
Sbjct: 111 G---DNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKN-MKDLTCRWTPGAHGETFLH 166

Query: 456 SLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRI 515
           +      +LR++     C +  ++ P S    C++  D         + L + Y +W+  
Sbjct: 167 TNYSLKYKLRWYGQDNTCEEYHTVGPHS----CHIPKD---------LALFTPYEIWVEA 213

Query: 516 NHSLGSLDSPP-TCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNL---QFQ 571
            + LGS  S   T  + D V    PP    + +      L + W  P   ++ L   ++Q
Sbjct: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273

Query: 572 IRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLC--AVYAVQVRCKRLD-----GLGYWSN 624
           IRY +    V WK   V D  S   S  +  L    VY VQVRC           G WS 
Sbjct: 274 IRYRVEDS-VDWK---VVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSE 329

Query: 625 WSNP 628
           WS+P
Sbjct: 330 WSHP 333



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 10/118 (8%)

Query: 223 QSPLMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVP---FPLQYQVKYSENS 277
           +S ++++  +++V  DPP  +H+      +  L + W SPP +    F  +YQ++Y    
Sbjct: 221 RSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVED 280

Query: 278 TTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRL-----DGPGIWSDWSTPRVFTT 330
           +   +  D + + TS  +  + PG+ Y VQVR            GIWS+WS P   +T
Sbjct: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAAST 338


>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
           sapiens]
          Length = 2299

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 7/124 (5%)

Query: 213 LKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFP-LQYQV 271
           + I+S    + SP+  +   N+ KP PP+ L  E      + +SW++PP      + Y V
Sbjct: 32  ITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYIV 91

Query: 272 KYSEN---STTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVF 328
           KY E      TV  +      +  +L+ ++ PG++YE++V  +   G G++SD   P +F
Sbjct: 92  KYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSD---PFLF 148

Query: 329 TTQD 332
            T +
Sbjct: 149 QTAE 152



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 33/106 (31%), Positives = 50/106 (47%), Gaps = 9/106 (8%)

Query: 524 SPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQW 583
           SP T ++  +V KP PP  +  E   + G+L +SW  P  P   +   I Y +  KEV  
Sbjct: 43  SPVTRIVTTNVTKPGPPVFLAGERVGSAGIL-LSWNTPPNPNGRI---ISYIVKYKEVCP 98

Query: 584 KMYEVY-DAKSKSVSLPV----PDLCAVYAVQVRCKRLDGLGYWSN 624
            M  VY   +SK  SL V     +    Y ++V  +   G+G +S+
Sbjct: 99  WMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSD 144


>gi|31083174 interleukin 21 receptor precursor [Homo sapiens]
          Length = 538

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 18/112 (16%)

Query: 235 VKPDPPLGLHMEITDDGNLKISWSSPPLVPF------PLQYQVKY-SENSTTVIREADKI 287
           +KP PP   ++ +T  G   ISW S    P        LQY+++Y +      +    K+
Sbjct: 118 IKPAPPF--NVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKL 175

Query: 288 VSATSLLVDSILP-----GSSYEVQVRGKRLDGP---GIWSDWSTPRVFTTQ 331
           +S  S  V S+LP      SSYE+QVR   + G    G WS+WS P +F TQ
Sbjct: 176 ISVDSRSV-SLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQ 226



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 44/230 (19%)

Query: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
           Y C       ++     + I    G+        L    +KP PP +V    +   G   
Sbjct: 79  YTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFS---GQYN 135

Query: 556 ISW----EKPVFP--ENNLQFQIRYGLSGKEVQWKMY---EVYDAKSKSVSLPVPDLC-- 604
           ISW    E P F   +  LQ++++Y   G    W +    ++    S+SVSL   +    
Sbjct: 136 ISWRSDYEDPAFYMLKGKLQYELQYRNRGDP--WAVSPRRKLISVDSRSVSLLPLEFRKD 193

Query: 605 AVYAVQVRCKRLDGLGY---WSNWSNPA---------------YTVVMDIKVPMRGPEFW 646
           + Y +QVR   + G  Y   WS WS+P                + +++ + V +  P FW
Sbjct: 194 SSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFW 253

Query: 647 RIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVG 696
            +       K   +  LWK +    ++ S +R+ +  +  C+G + + VG
Sbjct: 254 SL-------KTHPLWRLWKKIW---AVPSPERFFMPLYKGCSGDFKKWVG 293


>gi|11141869 interleukin 21 receptor precursor [Homo sapiens]
          Length = 538

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 18/112 (16%)

Query: 235 VKPDPPLGLHMEITDDGNLKISWSSPPLVPF------PLQYQVKY-SENSTTVIREADKI 287
           +KP PP   ++ +T  G   ISW S    P        LQY+++Y +      +    K+
Sbjct: 118 IKPAPPF--NVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKL 175

Query: 288 VSATSLLVDSILP-----GSSYEVQVRGKRLDGP---GIWSDWSTPRVFTTQ 331
           +S  S  V S+LP      SSYE+QVR   + G    G WS+WS P +F TQ
Sbjct: 176 ISVDSRSV-SLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQ 226



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 44/230 (19%)

Query: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
           Y C       ++     + I    G+        L    +KP PP +V    +   G   
Sbjct: 79  YTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFS---GQYN 135

Query: 556 ISW----EKPVFP--ENNLQFQIRYGLSGKEVQWKMY---EVYDAKSKSVSLPVPDLC-- 604
           ISW    E P F   +  LQ++++Y   G    W +    ++    S+SVSL   +    
Sbjct: 136 ISWRSDYEDPAFYMLKGKLQYELQYRNRGDP--WAVSPRRKLISVDSRSVSLLPLEFRKD 193

Query: 605 AVYAVQVRCKRLDGLGY---WSNWSNPA---------------YTVVMDIKVPMRGPEFW 646
           + Y +QVR   + G  Y   WS WS+P                + +++ + V +  P FW
Sbjct: 194 SSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFW 253

Query: 647 RIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVG 696
            +       K   +  LWK +    ++ S +R+ +  +  C+G + + VG
Sbjct: 254 SL-------KTHPLWRLWKKIW---AVPSPERFFMPLYKGCSGDFKKWVG 293


>gi|31083180 interleukin 21 receptor precursor [Homo sapiens]
          Length = 538

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 18/112 (16%)

Query: 235 VKPDPPLGLHMEITDDGNLKISWSSPPLVPF------PLQYQVKY-SENSTTVIREADKI 287
           +KP PP   ++ +T  G   ISW S    P        LQY+++Y +      +    K+
Sbjct: 118 IKPAPPF--NVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKL 175

Query: 288 VSATSLLVDSILP-----GSSYEVQVRGKRLDGP---GIWSDWSTPRVFTTQ 331
           +S  S  V S+LP      SSYE+QVR   + G    G WS+WS P +F TQ
Sbjct: 176 ISVDSRSV-SLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQ 226



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 44/230 (19%)

Query: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
           Y C       ++     + I    G+        L    +KP PP +V    +   G   
Sbjct: 79  YTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFS---GQYN 135

Query: 556 ISW----EKPVFP--ENNLQFQIRYGLSGKEVQWKMY---EVYDAKSKSVSLPVPDLC-- 604
           ISW    E P F   +  LQ++++Y   G    W +    ++    S+SVSL   +    
Sbjct: 136 ISWRSDYEDPAFYMLKGKLQYELQYRNRGDP--WAVSPRRKLISVDSRSVSLLPLEFRKD 193

Query: 605 AVYAVQVRCKRLDGLGY---WSNWSNPA---------------YTVVMDIKVPMRGPEFW 646
           + Y +QVR   + G  Y   WS WS+P                + +++ + V +  P FW
Sbjct: 194 SSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFW 253

Query: 647 RIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVG 696
            +       K   +  LWK +    ++ S +R+ +  +  C+G + + VG
Sbjct: 254 SL-------KTHPLWRLWKKIW---AVPSPERFFMPLYKGCSGDFKKWVG 293


>gi|4506107 prolactin receptor [Homo sapiens]
          Length = 622

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 48/179 (26%), Positives = 73/179 (40%), Gaps = 27/179 (15%)

Query: 190 VHECCECLVPVPTA--------KLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPL 241
           +HEC + +   P +         +  T +M +  T+      S  + V    +V+PDPPL
Sbjct: 72  MHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPL 131

Query: 242 GLHMEITDDGNLK----ISWSSPPLVP-----FPLQYQVKYSENSTTVIREADKIVSATS 292
            L +E+    + K    I WS P L+      F L Y+++          E       T 
Sbjct: 132 ELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAE-WEIHFAGQQTE 190

Query: 293 LLVDSILPGSSYEVQVRGKRLDGPGIWSDWS------TPRVFTTQD-VIYFPPKILTSV 344
             + S+ PG  Y VQVR K     G WS WS       P  FT  D  ++    +L++V
Sbjct: 191 FKILSLHPGQKYLVQVRCK--PDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAV 247



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 48/221 (21%), Positives = 79/221 (35%), Gaps = 47/221 (21%)

Query: 446 TCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFL 505
           TC W   T   L  +   L YHR           +    P  C+      Y  +++    
Sbjct: 45  TCWWRPGTDGGLP-TNYSLTYHREGETLMHECPDYITGGPNSCHFGKQ--YTSMWRT--- 98

Query: 506 LSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE------------------- 546
              Y M +   + +GS  S    V    +V+P PP  +  E                   
Sbjct: 99  ---YIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPT 155

Query: 547 -ITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCA 605
            I +  G   + +E  + PE   +++I +  +G++ ++K+  ++  +             
Sbjct: 156 LIDLKTGWFTLLYEIRLKPEKAAEWEIHF--AGQQTEFKILSLHPGQK------------ 201

Query: 606 VYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFW 646
            Y VQVRCK     GYWS WS PA  + +     M     W
Sbjct: 202 -YLVQVRCK--PDHGYWSAWS-PATFIQIPSDFTMNDTTVW 238


>gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
           [Homo sapiens]
          Length = 422

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 45/216 (20%), Positives = 80/216 (37%), Gaps = 4/216 (1%)

Query: 434 ISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSD 493
           +SC+   Y    +C WS S I  L    L   Y + ++  +D     P + P  C     
Sbjct: 118 VSCQAADY-ENFSCTWSPSQISGLPTRYLT-SYRKKTVLGADSQRRSPSTGPWPCPQDPL 175

Query: 494 GFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGL 553
           G   C+       S Y + +   + LG+  +    V   S+++P PP  ++ E       
Sbjct: 176 GAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVPGYPR 234

Query: 554 -LKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVR 612
            L+ SW  P        F +++ L  +  Q   +   +       +        +AV+V 
Sbjct: 235 RLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVS 294

Query: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRI 648
            +     G WS WS  A+       +P   P + ++
Sbjct: 295 ARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQL 330



 Score = 38.5 bits (88), Expect = 0.038
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 226 LMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVPFPLQYQVKYSENSTTVIRE 283
           L+ V   ++++PDPP GL +E        L+ SW+ P   P    + +K+          
Sbjct: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHP 266

Query: 284 ADKIVSATSL--LVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKI 340
           A   V    L  ++   + G  + V+V  +     G WS WS P  + T      P +I
Sbjct: 267 AWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWS-PEAWGTPSTGTIPKEI 324


>gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor
           [Homo sapiens]
          Length = 390

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 45/216 (20%), Positives = 80/216 (37%), Gaps = 4/216 (1%)

Query: 434 ISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSD 493
           +SC+   Y    +C WS S I  L    L   Y + ++  +D     P + P  C     
Sbjct: 118 VSCQAADY-ENFSCTWSPSQISGLPTRYLT-SYRKKTVLGADSQRRSPSTGPWPCPQDPL 175

Query: 494 GFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGL 553
           G   C+       S Y + +   + LG+  +    V   S+++P PP  ++ E       
Sbjct: 176 GAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVPGYPR 234

Query: 554 -LKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVR 612
            L+ SW  P        F +++ L  +  Q   +   +       +        +AV+V 
Sbjct: 235 RLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVS 294

Query: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRI 648
            +     G WS WS  A+       +P   P + ++
Sbjct: 295 ARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQL 330



 Score = 38.5 bits (88), Expect = 0.038
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 226 LMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVPFPLQYQVKYSENSTTVIRE 283
           L+ V   ++++PDPP GL +E        L+ SW+ P   P    + +K+          
Sbjct: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHP 266

Query: 284 ADKIVSATSL--LVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKI 340
           A   V    L  ++   + G  + V+V  +     G WS WS P  + T      P +I
Sbjct: 267 AWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWS-PEAWGTPSTGTIPKEI 324


>gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [Homo
           sapiens]
          Length = 422

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 45/216 (20%), Positives = 80/216 (37%), Gaps = 4/216 (1%)

Query: 434 ISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSD 493
           +SC+   Y    +C WS S I  L    L   Y + ++  +D     P + P  C     
Sbjct: 118 VSCQAADY-ENFSCTWSPSQISGLPTRYLT-SYRKKTVLGADSQRRSPSTGPWPCPQDPL 175

Query: 494 GFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGL 553
           G   C+       S Y + +   + LG+  +    V   S+++P PP  ++ E       
Sbjct: 176 GAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVPGYPR 234

Query: 554 -LKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVR 612
            L+ SW  P        F +++ L  +  Q   +   +       +        +AV+V 
Sbjct: 235 RLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVS 294

Query: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRI 648
            +     G WS WS  A+       +P   P + ++
Sbjct: 295 ARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQL 330



 Score = 38.5 bits (88), Expect = 0.038
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 226 LMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVPFPLQYQVKYSENSTTVIRE 283
           L+ V   ++++PDPP GL +E        L+ SW+ P   P    + +K+          
Sbjct: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHP 266

Query: 284 ADKIVSATSL--LVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKI 340
           A   V    L  ++   + G  + V+V  +     G WS WS P  + T      P +I
Sbjct: 267 AWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWS-PEAWGTPSTGTIPKEI 324


>gi|4885491 myeloproliferative leukemia virus oncogene precursor
           [Homo sapiens]
          Length = 635

 Score = 41.2 bits (95), Expect = 0.006
 Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 28/142 (19%)

Query: 445 MTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF------YEC 498
           +TC W     ++    T QL Y             +P  +P+ C L S         Y C
Sbjct: 48  LTCFWDEE--EAAPSGTYQLLY------------AYPREKPRACPLSSQSMPHFGTRYVC 93

Query: 499 IF---QPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
            F   + + L     +W++ N  L    +     + DSV  P PPS +KA      G L+
Sbjct: 94  QFPDQEEVRLFFPLHLWVK-NVFLNQTRTQRVLFV-DSVGLPAPPSIIKAMGGSQPGELQ 151

Query: 556 ISWEKPVFPE--NNLQFQIRYG 575
           ISWE+P  PE  + L++++RYG
Sbjct: 152 ISWEEPA-PEISDFLRYELRYG 172



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 37/136 (27%), Positives = 61/136 (44%), Gaps = 8/136 (5%)

Query: 206 NDTLLMCL-KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSP-PLV 263
           ND+++  L ++T+      S L S   I+     P   LH      G+L++ W  P    
Sbjct: 358 NDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWA 417

Query: 264 PFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGP---GIWS 320
                YQ++Y+       +  +  + A    ++ + P S Y +Q+R  RL+GP   G WS
Sbjct: 418 AQETCYQLRYTGEGHQDWKVLEPPLGARGGTLE-LRPRSRYRLQLRA-RLNGPTYQGPWS 475

Query: 321 DWSTP-RVFTTQDVIY 335
            WS P RV T  +  +
Sbjct: 476 SWSDPTRVETATETAW 491


>gi|10834992 interleukin 13 receptor, alpha 2 precursor [Homo
           sapiens]
          Length = 380

 Score = 41.2 bits (95), Expect = 0.006
 Identities = 36/144 (25%), Positives = 59/144 (40%), Gaps = 10/144 (6%)

Query: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKI 255
           C  P   A       +C+  +S     +S   + Q  N+VKP PP+ L         +K+
Sbjct: 197 CRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKL 256

Query: 256 SWSSPPLVPFP---LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGK- 311
            WS  PL P P     Y+++  E+ TT++      V   +  + +          VR K 
Sbjct: 257 KWSI-PLGPIPARCFDYEIEIREDDTTLVTAT---VENETYTLKTTNETRQLCFVVRSKV 312

Query: 312 --RLDGPGIWSDWSTPRVFTTQDV 333
                  GIWS+WS  + +  +D+
Sbjct: 313 NIYCSDDGIWSEWSDKQCWEGEDL 336


>gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo
           sapiens]
          Length = 468

 Score = 40.8 bits (94), Expect = 0.008
 Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
           +SC     L+ + C W   +  SL  ++ L +R  ++S             EP     +S
Sbjct: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171

Query: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551
             F   +  P    S Y + + +  S+GS  S         +++P PP+++    +  N 
Sbjct: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231

Query: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609
             L ++W+ P    N+  +++R+ L  +  + K +  +  K       + D  +   + V
Sbjct: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290

Query: 610 QVRCKRLDGLGYWSNWSNPA 629
           Q+R +   G G WS WS  A
Sbjct: 291 QLRAQEEFGQGEWSEWSPEA 310



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)

Query: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253
           C + VP    +  ++     +S G  F S   + Q   +++PDPP  + +         L
Sbjct: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234

Query: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305
            ++W  P         + F L+Y+ + S+  TT ++++          ++     G  + 
Sbjct: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289

Query: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338
           VQ+R +   G G WS+WS   + T       PP
Sbjct: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322


>gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
           sapiens]
          Length = 365

 Score = 40.8 bits (94), Expect = 0.008
 Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
           +SC     L+ + C W   +  SL  ++ L +R  ++S             EP     +S
Sbjct: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171

Query: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551
             F   +  P    S Y + + +  S+GS  S         +++P PP+++    +  N 
Sbjct: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231

Query: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609
             L ++W+ P    N+  +++R+ L  +  + K +  +  K       + D  +   + V
Sbjct: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290

Query: 610 QVRCKRLDGLGYWSNWSNPA 629
           Q+R +   G G WS WS  A
Sbjct: 291 QLRAQEEFGQGEWSEWSPEA 310



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)

Query: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253
           C + VP    +  ++     +S G  F S   + Q   +++PDPP  + +         L
Sbjct: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234

Query: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305
            ++W  P         + F L+Y+ + S+  TT ++++          ++     G  + 
Sbjct: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289

Query: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338
           VQ+R +   G G WS+WS   + T       PP
Sbjct: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322


>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
          Length = 629

 Score = 40.0 bits (92), Expect = 0.013
 Identities = 65/307 (21%), Positives = 121/307 (39%), Gaps = 44/307 (14%)

Query: 334 IYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393
           I+  P  +  +G N+S +C    +N   P K   +   + E+    Q   ++   +++ +
Sbjct: 34  IWVEPATIFKMGMNISIYCQAAIKN-CQPRKLHFYKNGIKERF---QITRINKTTARLWY 89

Query: 394 FNLNETKPRGKFTYDAVYC---CNEHE-----CHHRYAELYVIDVNINISCETDGYLTKM 445
            N  E        + ++YC   C +H      C    +  Y  D+   ++C    Y   M
Sbjct: 90  KNFLEP-------HASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNM 142

Query: 446 TCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFL 505
           TC W+   +  +            + Y   + S+   +E +  YL S  +       +  
Sbjct: 143 TCTWNAGKLTYI-----------DTKYVVHVKSLE--TEEEQQYLTS-SYINISTDSLQG 188

Query: 506 LSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK--ISWEKPVF 563
              Y +W++  ++LG  +S    +  D +V P      +AE TIN  + K  I W+    
Sbjct: 189 GKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAE-TINATVPKTIIYWDSQTT 247

Query: 564 PENNLQFQIRYGLSGKEVQWKMYEV---YDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLG 620
            E  +  ++RY  +  +  W + E    +    +S     P++   Y  QVRC+   G  
Sbjct: 248 IE-KVSCEMRYKATTNQT-WNVKEFDTNFTYVQQSEFYLEPNI--KYVFQVRCQE-TGKR 302

Query: 621 YWSNWSN 627
           YW  WS+
Sbjct: 303 YWQPWSS 309


>gi|4559408 colony stimulating factor 2 receptor, beta precursor
           [Homo sapiens]
          Length = 897

 Score = 40.0 bits (92), Expect = 0.013
 Identities = 35/155 (22%), Positives = 68/155 (43%), Gaps = 22/155 (14%)

Query: 189 SVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEIT 248
           S+H    C +PVP    +   ++ ++        +  + S   I M  P       + +T
Sbjct: 299 SLHTRHHCQIPVPDPATHGQYIVSVQPRRA----EKHIKSSVNIQMAPPS------LNVT 348

Query: 249 DDGN-LKISWSSPPLV------PFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPG 301
            DG+   + W +  +        F +QY+    + +T    + + + +A S+ + ++ P 
Sbjct: 349 KDGDSYSLRWETMKMRYEHIDHTFEIQYR---KDTATWKDSKTETLQNAHSMALPALEPS 405

Query: 302 SSY--EVQVRGKRLDGPGIWSDWSTPRVFTTQDVI 334
           + Y   V+VR  R    GIWS+WS  R + T+ V+
Sbjct: 406 TRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVL 440


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,797,932
Number of Sequences: 37866
Number of extensions: 2247507
Number of successful extensions: 5304
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 4928
Number of HSP's gapped (non-prelim): 397
length of query: 1165
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1052
effective length of database: 13,968,660
effective search space: 14695030320
effective search space used: 14695030320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press