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Search of human proteins with 40254446
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1
[Homo sapiens]
(780 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1 ... 1542 0.0
gi|32307161 cullin 1 [Homo sapiens] 340 2e-93
gi|19482174 cullin 2 [Homo sapiens] 292 7e-79
gi|4503165 cullin 3 [Homo sapiens] 243 5e-64
gi|121114302 cullin 4B isoform 2 [Homo sapiens] 238 1e-62
gi|121114298 cullin 4B isoform 1 [Homo sapiens] 238 1e-62
gi|57165424 cullin 4A isoform 1 [Homo sapiens] 228 2e-59
gi|11140811 cullin 4A isoform 2 [Homo sapiens] 227 4e-59
gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens] 41 0.004
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 40 0.006
gi|22749429 coiled-coil domain containing 89 [Homo sapiens] 39 0.024
gi|189217904 RPGRIP1-like isoform b [Homo sapiens] 37 0.092
gi|118442834 RPGRIP1-like isoform a [Homo sapiens] 37 0.092
gi|223671872 inhibitor of kappa light polypeptide gene enhancer ... 36 0.16
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 36 0.16
gi|118498362 kinectin 1 isoform b [Homo sapiens] 35 0.20
gi|110347443 TATA element modulatory factor 1 [Homo sapiens] 35 0.20
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 35 0.27
gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [H... 34 0.60
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 34 0.60
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 34 0.60
gi|37202123 NMDA receptor regulated 2 isoform a [Homo sapiens] 33 0.78
gi|151101140 coiled-coil domain containing 2 isoform a [Homo sap... 33 1.3
gi|151105223 coiled-coil domain containing 2 isoform a [Homo sap... 33 1.3
gi|151105229 coiled-coil domain containing 2 isoform a [Homo sap... 33 1.3
gi|100814339 coiled-coil domain containing 146 [Homo sapiens] 33 1.3
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 32 2.3
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 32 2.3
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 32 3.0
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 32 3.0
>gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1
[Homo sapiens]
Length = 780
Score = 1542 bits (3992), Expect = 0.0
Identities = 780/780 (100%), Positives = 780/780 (100%)
Query: 1 MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAK 60
MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAK
Sbjct: 1 MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAK 60
Query: 61 IHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMG 120
IHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMG
Sbjct: 61 IHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMG 120
Query: 121 KQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGV 180
KQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGV
Sbjct: 121 KQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGV 180
Query: 181 RESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE 240
RESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE
Sbjct: 181 RESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE 240
Query: 241 EEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLM 300
EEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLM
Sbjct: 241 EEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLM 300
Query: 301 DKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQ 360
DKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQ
Sbjct: 301 DKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQ 360
Query: 361 DDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTP 420
DDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTP
Sbjct: 361 DDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTP 420
Query: 421 LSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL 480
LSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL
Sbjct: 421 LSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL 480
Query: 481 REVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSS 540
REVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSS
Sbjct: 481 REVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSS 540
Query: 541 EKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQL 600
EKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQL
Sbjct: 541 EKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQL 600
Query: 601 AVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDF 660
AVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDF
Sbjct: 601 AVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDF 660
Query: 661 TEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAII 720
TEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAII
Sbjct: 661 TEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAII 720
Query: 721 QIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
QIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA
Sbjct: 721 QIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
>gi|32307161 cullin 1 [Homo sapiens]
Length = 776
Score = 340 bits (873), Expect = 2e-93
Identities = 238/794 (29%), Positives = 411/794 (51%), Gaps = 70/794 (8%)
Query: 19 WDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKG---------PAKIHQA----- 64
WD +R + ++ ++S+ K ++ +L++ V+ C + P+K +
Sbjct: 21 WDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGG 80
Query: 65 -------LKEDILEFIKQAQARVLSHQDDT---ALLKAYIVEWRKFFTQCDILPKPFCQL 114
L + + EF+K +L +D ++LK Y +W + +L L
Sbjct: 81 AQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYL 140
Query: 115 EITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDS 174
+ ++ + + + + L L TW + +F + ++ ++ +KL+ ER GE ++
Sbjct: 141 NRHWVRRECDEGRKGIYE--IYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINT 198
Query: 175 QLVIGVRESYVNLCSNPEDK------LQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQ 228
+L+ GV +SYV L N +D L +Y+++FE +L TERFY ++ +LQQN V
Sbjct: 199 RLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVT 258
Query: 229 NYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRN 288
YMK A+A+L EE++R YL + + L C L+ E E Q ++ +
Sbjct: 259 EYMKKAEARLLEEQRRVQVYLHESTQ----DELARKCEQVLIEKHLEIFHTEFQNLLDAD 314
Query: 289 ETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLF 348
+ E L M++L+ ++ +G+ + K LE HI + GLA + E D + YV+ +L +
Sbjct: 315 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVH 374
Query: 349 NRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELL 408
+++ LV AF +D F+ A DKA +N+ + K+ Q SK PELL
Sbjct: 375 KKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKM------------AQSSSKSPELL 422
Query: 409 ANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISA 468
A YCD LL+K+ SK E+E L +V++V KY+++KDVF +++ L +RL+ SA
Sbjct: 423 ARYCDSLLKKS--SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA 480
Query: 469 DSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNI 528
+ E +M+ L++ +Y +KL RMFQDI VS+DLN+ FK+ H N L D +I
Sbjct: 481 SDDAEASMISKLKQ-ACGFEYTSKLQRMFQDIGVSKDLNEQFKK-HLTNSEPLDLD-FSI 537
Query: 529 KILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEV 588
++L++G+W F +LP+ELE FY HSGRKL W + +S G +
Sbjct: 538 QVLSSGSWPFQQSCTF-ALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFK 596
Query: 589 GQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVL 648
+Y L+ +TFQ+A+L +N + + + L +T++ L + L L LK ++L
Sbjct: 597 NRYTLQASTFQMAILLQYN--TEDAYTVQQLTDSTQIKMDILAQVLQIL-----LKSKLL 649
Query: 649 LYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEE--NEG 706
+ E + N+ D E + +LIK K K+ + + + TE+ +E+E ++
Sbjct: 650 VLEDE-NANVDEVE------LKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKN 702
Query: 707 IVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYI 766
I + R L Q AI++IMKMRK + + QL E++ L + F P+ +IK+ I+ LIE +Y+
Sbjct: 703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYL 762
Query: 767 RRDESDINTFIYMA 780
R + + +T+ Y+A
Sbjct: 763 ERVDGEKDTYSYLA 776
>gi|19482174 cullin 2 [Homo sapiens]
Length = 745
Score = 292 bits (748), Expect = 7e-79
Identities = 212/787 (26%), Positives = 383/787 (48%), Gaps = 68/787 (8%)
Query: 13 LQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCL-WDDKGPAKIHQALKEDILE 71
+ F++ W+ + + ++ E V + W D FSD++A+C+ + + +++ K +
Sbjct: 8 VDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLEN 67
Query: 72 FIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKS--- 128
++ RVL ++ ++ Y W ++ D + + L + K +
Sbjct: 68 HVRHLHKRVLESEEQVLVM--YHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQY 125
Query: 129 -------NVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVR 181
N + +L LD W + + ++ L ++ + +R GE + +++ GV
Sbjct: 126 GYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVI 185
Query: 182 ESYVNLCSNPED-KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE 240
S+V++ + L+ Y++ FE +L T +Y+ +A + LQ++ YM+ +LK+
Sbjct: 186 NSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKD 245
Query: 241 EEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLM 300
EE R +YL +S ++ C +V + + AEC +I++ + + M+ L+
Sbjct: 246 EEIRCRKYLHP----SSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLL 301
Query: 301 DKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEK--YVEQLLTLFNRFSKLVKEA 358
V G+ M+++L+ HI GL A +T ++ +VE +L + +F +L+
Sbjct: 302 RAVSTGLPHMIQELQNHIHDEGLR----ATSNLTQENMPTLFVESVLEVHGKFVQLINTV 357
Query: 359 FQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKC--PELLANYCDMLL 416
D F++A DKA +VVN +P+S C PELLA YCD LL
Sbjct: 358 LNGDQHFMSALDKALTSVVN------------------YREPKSVCKAPELLAKYCDNLL 399
Query: 417 RKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENM 476
+K+ +K +T E+E +L + V KY+ +KDVF +++ L +RLI +S + EE M
Sbjct: 400 KKS--AKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAM 457
Query: 477 VEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPAD-SVNIKILNAGA 535
+ L++ ++ +KL RM+ D+ VS DLN F KN + S I +L AGA
Sbjct: 458 INKLKQA-CGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGA 516
Query: 536 W--SRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDL 593
W +++ F ++P ELE + E FY ++ SGRKL W H + G + Y
Sbjct: 517 WPLTQAPSSTF-AIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVA 575
Query: 594 EVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQ 653
VTT+Q+AVL A+N E +S++ L+ +T++ + EL +T+ SL+ +
Sbjct: 576 MVTTYQMAVLLAFNNS--ETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHD------- 626
Query: 654 VNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRIL 713
+ +D + FS+N FS KR K + +Q T + E+ + + R +
Sbjct: 627 -SEKEDIDAESSFSLNMNFS-------SKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKM 678
Query: 714 RTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDI 773
Q AI++IMK RK + + L E++ + F P MIK+ IE LI+ +YI R ++
Sbjct: 679 YLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASA 738
Query: 774 NTFIYMA 780
+ + Y+A
Sbjct: 739 DEYSYVA 745
>gi|4503165 cullin 3 [Homo sapiens]
Length = 768
Score = 243 bits (620), Expect = 5e-64
Identities = 207/792 (26%), Positives = 383/792 (48%), Gaps = 87/792 (10%)
Query: 19 WDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILE-FIKQAQ 77
WD ++ + ++ R+ + + + +L+ + + + L K K++ L+E + E I + +
Sbjct: 34 WDLLKNAIQEIQRKNN-SGLSFEELYRNAYTMVL--HKHGEKLYTGLREVVTEHLINKVR 90
Query: 78 ARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRK 137
VL+ ++ L+ W T ++ ++ + +++NVE+ V
Sbjct: 91 EDVLNSLNNN-FLQTLNQAWNDHQTAMVMIRDILMYMDRVYV------QQNNVEN--VYN 141
Query: 138 LMLDTWNESI--FSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKL 195
L L + + + + I++ L+ + + ++ ER GE D +R + L +
Sbjct: 142 LGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG---AIRNACQMLMILGLEGR 198
Query: 196 QIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRREC 255
+Y ++FE +L+ + F++ ++ +L +N Y+K +A++ EE +R + L+ E
Sbjct: 199 SVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTE- 257
Query: 256 NSVEALMECCVNALVTSFKETILA-ECQG---MIKRNETEKLHLMFSLMDKVPNGIEPML 311
E +++ L++ +TI+ E G M+K +TE L M+ L +VPNG++ M
Sbjct: 258 ---EPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMC 314
Query: 312 KDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDK 371
+ + ++ G A + + E + Y++ LL L +RF + + E+F +D F
Sbjct: 315 ECMSSYLREQGKA--LVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFK----- 367
Query: 372 AYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIE 431
+ + D F L L S+ PE L+ + D L+K K LT +E+E
Sbjct: 368 --QTIAGDFEYF-LNL-------------NSRSPEYLSLFIDDKLKKGV--KGLTEQEVE 409
Query: 432 AKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPADYV 490
L + +++ +++Q KDVF RY+K HL RRL+ + S + E+NM+ L+ E G +
Sbjct: 410 TILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECG--CQFT 467
Query: 491 NKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTE 550
+KL MF+D+ +S F++ + ++L + +++L G W S ++P
Sbjct: 468 SKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPA 527
Query: 551 LEDLIPEVEEFYKKNHSGRKLHWHHLMSNGII--TFKNEVGQYD---------------- 592
FY HSGR+L H M + + TF V + D
Sbjct: 528 PRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNT 587
Query: 593 ----LEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVL 648
L+V+TFQ+ +L +N R EK +FE ++ T++P+ EL R L SL A K ++VL
Sbjct: 588 RKHILQVSTFQMTILMLFNNR--EKYTFEEIQQETDIPERELVRALQSL-ACGKPTQRVL 644
Query: 649 LYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIV 708
EP+ K+ G +F+VN +F+ +K+ R KI + Q ++ R+E + +
Sbjct: 645 TKEPK---SKEIENGHIFTVNDQFT----SKLH-RVKIQTVAAKQGESDPERKETRQKVD 696
Query: 709 QLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRR 768
R + AI++IMK RKK+ + L E+ + LK FLP +IK++IE LIE +Y+ R
Sbjct: 697 DDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLAR 756
Query: 769 DESDINTFIYMA 780
D + Y+A
Sbjct: 757 TPEDRKVYTYVA 768
>gi|121114302 cullin 4B isoform 2 [Homo sapiens]
Length = 895
Score = 238 bits (608), Expect = 1e-62
Identities = 209/773 (27%), Positives = 378/773 (48%), Gaps = 81/773 (10%)
Query: 16 EDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQ 75
++ W ++ V + S+ K +L+ V +C + K A +++ L++ + IK
Sbjct: 196 DETWQKLKEAVEAIQNSTSI-KYNLEELYQAVENLCSY--KISANLYKQLRQICEDHIKA 252
Query: 76 AQARVLSHQDDTAL-LKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSI 134
+ D+ L LK W+ Q ++ F L+ T + Q S S
Sbjct: 253 QIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYV-LQNSMLPS------ 305
Query: 135 VRKLMLDTWNESIFSN--IKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPE 192
+ + L+ + I S+ ++N+ D + L+ ER GEA D L+ S +++ S+
Sbjct: 306 IWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLL----RSLLSMLSD-- 359
Query: 193 DKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETR 252
LQIY+D+FE+ +L+ T R Y + +Q+ V Y+ + + +L+EE R + YL+
Sbjct: 360 --LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQT 417
Query: 253 RECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLK 312
+ + + + + + +T+ + L ++ N + L L++ L +V G++ +L+
Sbjct: 418 TQKSLIATVEKQLLGEHLTAILQKGL---NNLLDENRIQDLSLLYQLFSRVRGGVQVLLQ 474
Query: 313 DLEEHIISAGLADMVAAAETITTDSEK---YVEQLLTLFNRFSKLVKEAFQDDPRFLTAR 369
E+I + G TI + EK V++LL ++ ++ F + +F+ A
Sbjct: 475 QWIEYIKAFG--------STIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAM 526
Query: 370 DKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEE 429
+A++ +N + +K EL+A Y D LR +K+ T EE
Sbjct: 527 KEAFETFIN--------------------KRPNKPAELIAKYVDSKLRAG--NKEATDEE 564
Query: 430 IEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPAD 488
+E L +++++ +++ KDVF ++K L +RL++ SA + E++M+ L+ E G A
Sbjct: 565 LEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--AA 622
Query: 489 YVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPAD-SVNIKILNAGAWSRSSEKVFVSL 547
+ +KL MF+D+++S+D+ FK+ +N +P + + + IL G W + + V L
Sbjct: 623 FTSKLEGMFKDMELSKDIMIQFKQYMQNQN--VPGNIELTVNILTMGYWP-TYVPMEVHL 679
Query: 548 PTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWN 607
P E+ L + FY HSGRKL W + + ++ + + G+ +L+V+ FQ VL +N
Sbjct: 680 PPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFN 739
Query: 608 QRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFS 667
+ E+ S E +K AT + D ELRRTL SL K +VL P+ KD +G F
Sbjct: 740 E--GEEFSLEEIKQATGIEDGELRRTLQSLACG---KARVLAKNPK---GKDIEDGDKFI 791
Query: 668 VNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRK 727
N +F R KIN I + E + E + Q R + AI++IMKMRK
Sbjct: 792 CNDDFK-----HKLFRIKINQIQMKETVEE--QASTTERVFQDRQYQIDAAIVRIMKMRK 844
Query: 728 KISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
+S+ L +E+ LK F + +K++IE LI+ Y+ RD+ + N + Y+A
Sbjct: 845 TLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 895
>gi|121114298 cullin 4B isoform 1 [Homo sapiens]
Length = 913
Score = 238 bits (608), Expect = 1e-62
Identities = 209/773 (27%), Positives = 378/773 (48%), Gaps = 81/773 (10%)
Query: 16 EDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQ 75
++ W ++ V + S+ K +L+ V +C + K A +++ L++ + IK
Sbjct: 214 DETWQKLKEAVEAIQNSTSI-KYNLEELYQAVENLCSY--KISANLYKQLRQICEDHIKA 270
Query: 76 AQARVLSHQDDTAL-LKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSI 134
+ D+ L LK W+ Q ++ F L+ T + Q S S
Sbjct: 271 QIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYV-LQNSMLPS------ 323
Query: 135 VRKLMLDTWNESIFSN--IKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPE 192
+ + L+ + I S+ ++N+ D + L+ ER GEA D L+ S +++ S+
Sbjct: 324 IWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLL----RSLLSMLSD-- 377
Query: 193 DKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETR 252
LQIY+D+FE+ +L+ T R Y + +Q+ V Y+ + + +L+EE R + YL+
Sbjct: 378 --LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQT 435
Query: 253 RECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLK 312
+ + + + + + +T+ + L ++ N + L L++ L +V G++ +L+
Sbjct: 436 TQKSLIATVEKQLLGEHLTAILQKGL---NNLLDENRIQDLSLLYQLFSRVRGGVQVLLQ 492
Query: 313 DLEEHIISAGLADMVAAAETITTDSEK---YVEQLLTLFNRFSKLVKEAFQDDPRFLTAR 369
E+I + G TI + EK V++LL ++ ++ F + +F+ A
Sbjct: 493 QWIEYIKAFG--------STIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAM 544
Query: 370 DKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEE 429
+A++ +N + +K EL+A Y D LR +K+ T EE
Sbjct: 545 KEAFETFIN--------------------KRPNKPAELIAKYVDSKLRAG--NKEATDEE 582
Query: 430 IEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPAD 488
+E L +++++ +++ KDVF ++K L +RL++ SA + E++M+ L+ E G A
Sbjct: 583 LEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--AA 640
Query: 489 YVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPAD-SVNIKILNAGAWSRSSEKVFVSL 547
+ +KL MF+D+++S+D+ FK+ +N +P + + + IL G W + + V L
Sbjct: 641 FTSKLEGMFKDMELSKDIMIQFKQYMQNQN--VPGNIELTVNILTMGYWP-TYVPMEVHL 697
Query: 548 PTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWN 607
P E+ L + FY HSGRKL W + + ++ + + G+ +L+V+ FQ VL +N
Sbjct: 698 PPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFN 757
Query: 608 QRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFS 667
+ E+ S E +K AT + D ELRRTL SL K +VL P+ KD +G F
Sbjct: 758 E--GEEFSLEEIKQATGIEDGELRRTLQSLACG---KARVLAKNPK---GKDIEDGDKFI 809
Query: 668 VNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRK 727
N +F R KIN I + E + E + Q R + AI++IMKMRK
Sbjct: 810 CNDDFK-----HKLFRIKINQIQMKETVEE--QASTTERVFQDRQYQIDAAIVRIMKMRK 862
Query: 728 KISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
+S+ L +E+ LK F + +K++IE LI+ Y+ RD+ + N + Y+A
Sbjct: 863 TLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 913
>gi|57165424 cullin 4A isoform 1 [Homo sapiens]
Length = 759
Score = 228 bits (580), Expect = 2e-59
Identities = 203/773 (26%), Positives = 372/773 (48%), Gaps = 81/773 (10%)
Query: 16 EDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQ 75
+D W + V + S+ + +L+ V +C K +++ L++ + +
Sbjct: 60 QDTWRKLHEAVRAVQSSTSI-RYNLEELYQAVENLC--SHKVSPMLYKQLRQACEDHV-- 114
Query: 76 AQARVLSHQDDTA----LLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVE 131
QA++L ++D+ LK W+ Q ++ F L+ T + Q S S
Sbjct: 115 -QAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV-LQNSTLPS--- 169
Query: 132 DSIVRKLMLDTWNESIFSN--IKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCS 189
+ + L+ + I S+ ++++ D + L+ ER GEA D L+ S + + S
Sbjct: 170 ---IWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLL----RSLLGMLS 222
Query: 190 NPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYL 249
+ LQ+Y+D+FE +L+ T Y + +Q+ V Y+ + +L+EE R + YL
Sbjct: 223 D----LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYL 278
Query: 250 ETRRECNSVEALMECCVNALVTSFKETILAE-CQGMIKRNETEKLHLMFSLMDKVPNGIE 308
+ + + L+ C L+ IL + ++ N L M+ L +V G +
Sbjct: 279 DHSTQ----KPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQ 334
Query: 309 PMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTA 368
+L+ E+I + G A ++ + + V+ LL ++ +++ FQ + RF+
Sbjct: 335 ALLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIEVCFQKNERFVNL 389
Query: 369 RDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSE 428
++++ +N + +K EL+A + D LR +K+ T E
Sbjct: 390 MKESFETFIN--------------------KRPNKPAELIAKHVDSKLRAG--NKEATDE 427
Query: 429 EIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPA 487
E+E L +++++ +++ KDVF ++K L +RL++ SA + E++M+ L+ E G A
Sbjct: 428 ELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--A 485
Query: 488 DYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSL 547
+ +KL MF+D+++S+D+ FK+ +N + P D + + IL G W + + V L
Sbjct: 486 AFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPID-LTVNILTMGYWP-TYTPMEVHL 543
Query: 548 PTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWN 607
E+ L + FY HSGRKL W + + ++ + + G+ + +V+ FQ VL +N
Sbjct: 544 TPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFN 603
Query: 608 QRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFS 667
+ + SFE +K+AT + D+ELRRTL SL K +VL+ P+ K+ +G F
Sbjct: 604 E--GDGFSFEEIKMATGIEDSELRRTLQSLACG---KARVLIKSPK---GKEVEDGDKFI 655
Query: 668 VNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRK 727
N EF R KIN I + E++ E + Q R + AI++IMKMRK
Sbjct: 656 FNGEFK-----HKLFRIKINQIQMKETVEEQV--STTERVFQDRQYQIDAAIVRIMKMRK 708
Query: 728 KISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
+ + L +EL LK F + +K++IE LI+ Y+ RD+ + N + Y+A
Sbjct: 709 TLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
>gi|11140811 cullin 4A isoform 2 [Homo sapiens]
Length = 659
Score = 227 bits (578), Expect = 4e-59
Identities = 194/712 (27%), Positives = 348/712 (48%), Gaps = 75/712 (10%)
Query: 77 QARVLSHQDDTA----LLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVED 132
QA++L ++D+ LK W+ Q ++ F L+ T + Q S S
Sbjct: 15 QAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV-LQNSTLPS---- 69
Query: 133 SIVRKLMLDTWNESIFSN--IKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSN 190
+ + L+ + I S+ ++++ D + L+ ER GEA D L+ S + + S+
Sbjct: 70 --IWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLL----RSLLGMLSD 123
Query: 191 PEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLE 250
LQ+Y+D+FE +L+ T Y + +Q+ V Y+ + +L+EE R + YL+
Sbjct: 124 ----LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLD 179
Query: 251 TRRECNSVEALMECCVNALVTSFKETILAE-CQGMIKRNETEKLHLMFSLMDKVPNGIEP 309
+ + L+ C L+ IL + ++ N L M+ L +V G +
Sbjct: 180 HSTQ----KPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQA 235
Query: 310 MLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTAR 369
+L+ E+I + G A ++ + + V+ LL ++ +++ FQ + RF+
Sbjct: 236 LLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLM 290
Query: 370 DKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEE 429
++++ +N + +K EL+A + D LR +K+ T EE
Sbjct: 291 KESFETFIN--------------------KRPNKPAELIAKHVDSKLRAG--NKEATDEE 328
Query: 430 IEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPAD 488
+E L +++++ +++ KDVF ++K L +RL++ SA + E++M+ L+ E G A
Sbjct: 329 LERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--AA 386
Query: 489 YVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLP 548
+ +KL MF+D+++S+D+ FK+ +N + P D + + IL G W + + V L
Sbjct: 387 FTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPID-LTVNILTMGYWP-TYTPMEVHLT 444
Query: 549 TELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQ 608
E+ L + FY HSGRKL W + + ++ + + G+ + +V+ FQ VL +N+
Sbjct: 445 PEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNE 504
Query: 609 RPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSV 668
+ SFE +K+AT + D+ELRRTL SL K +VL+ P+ K+ +G F
Sbjct: 505 --GDGFSFEEIKMATGIEDSELRRTLQSLACG---KARVLIKSPK---GKEVEDGDKFIF 556
Query: 669 NQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKK 728
N EF R KIN I + E++ E + Q R + AI++IMKMRK
Sbjct: 557 NGEFK-----HKLFRIKINQIQMKETVEEQV--STTERVFQDRQYQIDAAIVRIMKMRKT 609
Query: 729 ISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
+ + L +EL LK F + +K++IE LI+ Y+ RD+ + N + Y+A
Sbjct: 610 LGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
>gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens]
Length = 822
Score = 41.2 bits (95), Expect = 0.004
Identities = 58/256 (22%), Positives = 108/256 (42%), Gaps = 30/256 (11%)
Query: 437 VLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARM 496
+ L++ +KD+F+ +++ L RL+ S E E VE L+ + ++ M
Sbjct: 502 ISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLK-LRFGEAPMHFCEVM 560
Query: 497 FQDIKVSEDLNQAFKEM-HKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLI 555
+D+ S +N +E K P V IL++ W ++ + +P ++ +
Sbjct: 561 LKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEK-LEVPEDIRAAL 619
Query: 556 PEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKIS 615
+ Y++ + R L W H + G++T E+ L V + + + + +
Sbjct: 620 EAYCKKYEQLKAMRTLSWKHTL--GLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWT 677
Query: 616 FENLKLATELPDAELRR--TLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFS 673
E L A ++P A LRR ++W L++ VL EP GT FS
Sbjct: 678 LEELSKAVKMPVALLRRRMSVW-------LQQGVLREEP---------PGT-------FS 714
Query: 674 LIKNAKVQKRGKINLI 689
+I+ + Q R + LI
Sbjct: 715 VIEEERPQDRDNMVLI 730
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 40.4 bits (93), Expect = 0.006
Identities = 90/458 (19%), Positives = 184/458 (40%), Gaps = 44/458 (9%)
Query: 138 LMLDTWNESIFSNIKN----RLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPED 193
L+L WN F +KN RL LV + +GE V G++E L +
Sbjct: 823 LILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEE-----VAGLKEECAQL-QKALE 876
Query: 194 KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRR 253
K + R+ + + T+ +Q + N + + +K + + R E
Sbjct: 877 KSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSE 936
Query: 254 ECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKD 313
E +N+ +T+ + EC + K E + L M +K E +K+
Sbjct: 937 RVEEEEE-----INSELTARGRKLEDECFELKK--EIDDLETMLVKSEKEKRTTEHKVKN 989
Query: 314 LEEHI--ISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAF---QDDPRFLTA 368
L E + ++ ++ + AA+ + ++ ++ L + S L K Q A
Sbjct: 990 LTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGA 1049
Query: 369 RDKAYKAVVN-DATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTS 427
++ KA +N + + KLE LK ++ ES L L + ++ K+ +
Sbjct: 1050 LEQERKARMNCERELHKLEGNLKLNRESMENL-ESSQRHLAEELRKKELELSQMNSKVEN 1108
Query: 428 E-----EIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISAD-SEIEENMVEW-- 479
E +++ +KE+ +K ++ K R +A + R D++ D +++ E + E
Sbjct: 1109 EKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERA-DLTQDLADLNERLEEVGG 1167
Query: 480 --LREVGMPADYVNKLARMFQDIKVS----EDLNQAFKEMHKNNKLALPADSVNIKILNA 533
L ++ + K ++ +D++ + E + + K+ H ++ L N++ +
Sbjct: 1168 SSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVK- 1226
Query: 534 GAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKL 571
+ EK L E++DL+ VE+ + + KL
Sbjct: 1227 ----QKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKL 1260
>gi|22749429 coiled-coil domain containing 89 [Homo sapiens]
Length = 374
Score = 38.5 bits (88), Expect = 0.024
Identities = 25/105 (23%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 458 LTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNN 517
L R IL++ ++E+EE M++ ++ +Y KL F + + +L FK+ +K+
Sbjct: 88 LERCQILEL-LNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSE 146
Query: 518 KLALPADSVNIKILNAGAWS---RSSEKVFVSLPTELEDLIPEVE 559
+ L ++ +++ N+ +S + E + L E L E+E
Sbjct: 147 NIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELE 191
>gi|189217904 RPGRIP1-like isoform b [Homo sapiens]
Length = 1235
Score = 36.6 bits (83), Expect = 0.092
Identities = 84/407 (20%), Positives = 166/407 (40%), Gaps = 53/407 (13%)
Query: 150 NIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPE----DKLQIYRDNFE-- 203
N++N +Q ++ E L E +QL E ++L E D+ RDN E
Sbjct: 210 NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMI 269
Query: 204 KAYLDSTERFYRTQAPS--YLQQNGVQNYMKYA-DAKLKEEEKRALRYLETRRECNSVEA 260
K + E+ A ++Q Q ++ + DA + ++ ++ E R +C S+E
Sbjct: 270 KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEK 329
Query: 261 LMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFS---LMDKVPNGIEPMLKDLEEH 317
+ F E + E Q I E E+ L + L D + L+E
Sbjct: 330 QLHSM------KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ 383
Query: 318 IISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTAR---DKAYK 374
+ +A + A ++ TD + +++L T ++ KLV+E + ++L + D+ K
Sbjct: 384 QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKK 443
Query: 375 AV-----VNDATIFKLELPLKQKGVGLKTQPESKCPEL---------LANYCDMLLRKTP 420
+ ND +L L + +K Q E K +L + + +R+
Sbjct: 444 RIKLYNQENDINADELSEAL----LLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQ 499
Query: 421 LSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL 480
+ T +E+E +L++++ NKD M + R + ++ D E++ + +++
Sbjct: 500 ATHAETVQELEKTRN--MLIMQHKINKDYQM---EVEAVTRKMENLQQDYELK--VEQYV 552
Query: 481 REVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVN 527
+ + A ++KL +DI + +K +P DSV+
Sbjct: 553 HLLDIRAARIHKLEAQLKDIAYG-------TKQYKFKPEIMPDDSVD 592
Score = 32.3 bits (72), Expect = 1.7
Identities = 24/87 (27%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Query: 671 EFSLIKNAKVQKRGKINLIGRL-QLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKI 729
E ++N +RG+I + L ++ ++R +ENE + L LR Q+A Q +R +
Sbjct: 207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266
Query: 730 SNAQLQTELVEILKNMFLPQKKMIKEQ 756
+L +LVE + + K I+ Q
Sbjct: 267 EMIKLHKQLVEKSNALSAMEGKFIQLQ 293
>gi|118442834 RPGRIP1-like isoform a [Homo sapiens]
Length = 1315
Score = 36.6 bits (83), Expect = 0.092
Identities = 84/407 (20%), Positives = 166/407 (40%), Gaps = 53/407 (13%)
Query: 150 NIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPE----DKLQIYRDNFE-- 203
N++N +Q ++ E L E +QL E ++L E D+ RDN E
Sbjct: 210 NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMI 269
Query: 204 KAYLDSTERFYRTQAPS--YLQQNGVQNYMKYA-DAKLKEEEKRALRYLETRRECNSVEA 260
K + E+ A ++Q Q ++ + DA + ++ ++ E R +C S+E
Sbjct: 270 KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEK 329
Query: 261 LMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFS---LMDKVPNGIEPMLKDLEEH 317
+ F E + E Q I E E+ L + L D + L+E
Sbjct: 330 QLHSM------KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ 383
Query: 318 IISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTAR---DKAYK 374
+ +A + A ++ TD + +++L T ++ KLV+E + ++L + D+ K
Sbjct: 384 QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKK 443
Query: 375 AV-----VNDATIFKLELPLKQKGVGLKTQPESKCPEL---------LANYCDMLLRKTP 420
+ ND +L L + +K Q E K +L + + +R+
Sbjct: 444 RIKLYNQENDINADELSEAL----LLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQ 499
Query: 421 LSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL 480
+ T +E+E +L++++ NKD M + R + ++ D E++ + +++
Sbjct: 500 ATHAETVQELEKTRN--MLIMQHKINKDYQM---EVEAVTRKMENLQQDYELK--VEQYV 552
Query: 481 REVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVN 527
+ + A ++KL +DI + +K +P DSV+
Sbjct: 553 HLLDIRAARIHKLEAQLKDIAYG-------TKQYKFKPEIMPDDSVD 592
Score = 32.3 bits (72), Expect = 1.7
Identities = 24/87 (27%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Query: 671 EFSLIKNAKVQKRGKINLIGRL-QLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKI 729
E ++N +RG+I + L ++ ++R +ENE + L LR Q+A Q +R +
Sbjct: 207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266
Query: 730 SNAQLQTELVEILKNMFLPQKKMIKEQ 756
+L +LVE + + K I+ Q
Sbjct: 267 EMIKLHKQLVEKSNALSAMEGKFIQLQ 293
>gi|223671872 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform c [Homo sapiens]
Length = 320
Score = 35.8 bits (81), Expect = 0.16
Identities = 40/148 (27%), Positives = 60/148 (40%), Gaps = 15/148 (10%)
Query: 238 LKEEEKRALRYLETRRECNSVEALMECCVNALVTSF----------KETILAECQGMIKR 287
LK ++++ALR +E + C A + V A VTS E ECQ + R
Sbjct: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
Query: 288 NETEKLHLMF-SLMDKVPNGIEPMLKDLEEHIISAGLADMVA---AAETITTDSEKYVEQ 343
+ +L + + L + N I+ + E AD A A E + E EQ
Sbjct: 174 RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQ 233
Query: 344 LLTLFNRFSKLVKEAFQDDPRFLTARDK 371
L L +SKL K + Q+ R R +
Sbjct: 234 LEQLQREYSKL-KASCQESARIEDMRKR 260
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 35.8 bits (81), Expect = 0.16
Identities = 93/509 (18%), Positives = 201/509 (39%), Gaps = 74/509 (14%)
Query: 239 KEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFS 298
+E+ +R R E + +E+L+E + +E + + +T+ L +
Sbjct: 327 EEDHERTRRLAEAEMHVHHLESLLEQKEKEN-SMLREEMHRRFENAPDSAKTKALQTVIE 385
Query: 299 LMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEA 358
+ D + +E L+DLEE I M+ + ++T+ + + + ++ SK +K
Sbjct: 386 MKDSKISSMERGLRDLEEEI------QMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK 439
Query: 359 FQDDPRFLTARDKAY-----KAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCD 413
+ L++++ + KA A I +++ L +K L ++K L + D
Sbjct: 440 VEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLAL-QTKLETLTNQFSD 498
Query: 414 MLLRKTPLSKKLTSEEIEAKL--KEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSE 471
L + LT++E A + EV + ++ K+ + + + I D++ +
Sbjct: 499 SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML-----NKKTKQIQDMAEEKG 553
Query: 472 IEENMVEWLRE-VGMPADYVNKLARMFQDIKVSEDLNQAFKEMH--KNNKLALPADSVNI 528
+ + L++ + + VN L + ++++ E L K+M K +L AD+ N
Sbjct: 554 TQAGEIHDLKDMLDVKERKVNVLQKKIENLQ--EQLRDKEKQMSSLKERVKSLQADTTNT 611
Query: 529 KIL--------------------NAGAWSRSSEKVFVSLPTELEDLIPEVE----EFYKK 564
R ++ + +L+DL +V + +K
Sbjct: 612 DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEK 671
Query: 565 NHS--GRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLA 622
S K H L S+G+ + D + T ++A+ E+ E LK+
Sbjct: 672 EASLLDLKEHASSLASSGL--------KKDSRLKTLEIAL---------EQKKEECLKME 714
Query: 623 TELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQK 682
++L A A P++ ++ E ++ KD + V++ ++K + +K
Sbjct: 715 SQLKKA--HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 772
Query: 683 RGKINLIGRLQLTTERMREEENEGIVQLR 711
K I L ER +++N+ + L+
Sbjct: 773 NDKDKKIAEL----ERQVKDQNKKVANLK 797
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 35.4 bits (80), Expect = 0.20
Identities = 108/505 (21%), Positives = 197/505 (39%), Gaps = 79/505 (15%)
Query: 113 QLEITLMG-KQGSNKKSNVEDSIVRKLM-LDTWNESIFSNIK---NRLQDSAMKLVHAER 167
QLE LM + K+ N E+S+ ++ + NE++ + I+ +++ V AE
Sbjct: 545 QLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEE 604
Query: 168 LGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGV 227
L + VI ++ + ED L RD E Q ++L + V
Sbjct: 605 LHK------VIAEKDKQIK---QTEDSLASERDRLTS----KEEELKDIQNMNFLLKAEV 651
Query: 228 QNYMKYADAKLKEEEKRALRYLETRREC-----NSVEALMECCVNALVTSFKETILAECQ 282
Q A+ E+ A LE ++ + + L E + + +E + Q
Sbjct: 652 QKLQALAN-----EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
Query: 283 GMIKRNETEKLHLMFS---------LMDKVPNGIEPMLKDLEEHIISAGLADMVAAAE-- 331
++E +KL + S M+K + LK +EE ++ GL + E
Sbjct: 707 NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE-LLETGLIQVATKEEEL 765
Query: 332 -TITTDSEKYVEQLLTLFNR------FSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFK 384
I T++ +++ L + F+ LV+E + + +D K+V
Sbjct: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEEL----KKVIHEKDGKIKSVEELLEAEL 821
Query: 385 LELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPL--SKKLTSEEIEAKLKEVLLVLK 442
L++ K+K V L SK EL ++L K + K EE E L L+
Sbjct: 822 LKVANKEKTVQLSIT--SKVQELQ----NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ 875
Query: 443 YVQNKDVFMRYHKAHLTRRLILDISADSEIEENMV-------EWLREVGMPADYVNKLAR 495
+Q ++ ++ H + + + + S+ S+ EE + E R M + + L+
Sbjct: 876 DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSS 935
Query: 496 MFQDIKVSEDLNQAFKEMHKNNKL-------ALPADSVNIKILNAGAWSRSSEKVFVSLP 548
Q ++ +D N+ FK + K + P +K+++ EK L
Sbjct: 936 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVIS------EREKEISGLW 989
Query: 549 TELEDLIPEVEEFYKKNHSGRKLHW 573
EL+ L VE KKN+ R+ +W
Sbjct: 990 NELDSLKDAVEHQRKKNNDLREKNW 1014
>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
Length = 1093
Score = 35.4 bits (80), Expect = 0.20
Identities = 48/220 (21%), Positives = 91/220 (41%), Gaps = 17/220 (7%)
Query: 298 SLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKE 357
+++DKV EP E + D+ E + EK QLL+L ++ L++E
Sbjct: 422 TVLDKVAEQCEPAESQPEA---LSEKEDVCKTVEFLNEKLEKREAQLLSL-SKEKALLEE 477
Query: 358 AFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLR 417
AF + +D+ ++ ++I L+ Q+ + + + C E A ++
Sbjct: 478 AFDN------LKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNI 531
Query: 418 KTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMV 477
K L+ +L S E LKE ++ + + + + H +I + A + ENMV
Sbjct: 532 KEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLH-NSNIIKKLRAKDKENENMV 590
Query: 478 EWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNN 517
L + V +L Q +K D + ++ H+ N
Sbjct: 591 AKLNK------KVKELEEELQHLKQVLDGKEEVEKQHREN 624
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 35.0 bits (79), Expect = 0.27
Identities = 38/179 (21%), Positives = 77/179 (43%), Gaps = 32/179 (17%)
Query: 209 STERFYRTQAPSYLQQN--GVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCV 266
+TE+ Q LQ+ ++ +K L+EE++RA LE ++ C S
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS--------- 737
Query: 267 NALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDL------EEHIIS 320
+ AE + ++++++ E+ L + G+E L+ L E ++
Sbjct: 738 ---------ELKAETRSLVEQHKRERKELEEERAGR--KGLEARLQQLGEAHQAETEVLR 786
Query: 321 AGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRF----LTARDKAYKA 375
LA+ +AA T ++ E+ V+++ R+ +E Q F +T +++ KA
Sbjct: 787 RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKA 845
>gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [Homo
sapiens]
Length = 4515
Score = 33.9 bits (76), Expect = 0.60
Identities = 74/338 (21%), Positives = 135/338 (39%), Gaps = 50/338 (14%)
Query: 118 LMGKQGSNKKSN--VEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQ 175
+M +G + + N V S++ +D W E R + A+ +V L E + +
Sbjct: 2795 IMSPEGPSFRQNCRVYPSMISSCTID-WYE--------RWPEEALLIVANSFLKEKVNFE 2845
Query: 176 LVIGVRESYVNLCSNPEDKLQIYRD--NFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKY 233
++E C +QI++ + + Y + T RFY T SYLQ +M+
Sbjct: 2846 NRENLKEKLAPTC------VQIHKSMKDLNRKYFEETGRFYYTTPNSYLQ------FMET 2893
Query: 234 ADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETIL-AECQGMIKRNETEK 292
L+ E+ ++T+R+ + LVT +E +L Q K ETE
Sbjct: 2894 FAHILRAREEE----MQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETET 2949
Query: 293 LHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTD-SEKYVEQLLTLFNRF 351
L +V ++ ++K EE +VA I D ++K +L ++ F
Sbjct: 2950 LMEKLRKDSQVVEKVQMLVKQDEE---------IVAEEVRIVEDYAQKTANELKSVLPAF 3000
Query: 352 SKLVKEAFQDDPRFLTARDKAYKAVVNDAT--IFKLELPLKQKGVGLKTQPESKCPELLA 409
K + L A DKA A + T F + + + L+ +P +LL
Sbjct: 3001 DKAIVA--------LNALDKADVAELRVYTRPPFLVLTVMNAVCILLQKKPNWATAKLLL 3052
Query: 410 NYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNK 447
+ L + L K +++ KLK+++ + + +K
Sbjct: 3053 SETGFLKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHK 3090
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 33.9 bits (76), Expect = 0.60
Identities = 137/616 (22%), Positives = 249/616 (40%), Gaps = 74/616 (12%)
Query: 140 LDTWNESIFSNIKNRLQDSAMKLVHA-----ERLGEAFDSQLVIGVRESYVNLCSNPEDK 194
+D NE + NI +RLQ + KL+ A +L A +Q + +RES+ +
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL-MRESFRQK-QEATES 1892
Query: 195 LQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLK-----EEEKRALRYL 249
L+ + E+ + +S R A + GV + YAD K +E+ + L
Sbjct: 1893 LKCQEELRERLHEESRAR--EQLAVELSKAEGVID--GYADEKTLFERQIQEKTDIIDRL 1948
Query: 250 ETRRECNS-----VEALMECCVNA--LVTSFKETILAECQGMIKRNETEKLHLMFSLMDK 302
E C S +EA + L++ KE + AE G +++ ++ + +
Sbjct: 1949 EQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA-GPVEQQLLQETEKLMKEKLE 2007
Query: 303 VPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDD 362
V E + DL++ + + + + I + EK E L+ L + L K+ +
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE-LMDLRQQNQALEKQ-LEKM 2065
Query: 363 PRFLT--ARDKAYKAVVNDATIFKLELPLKQKGVGLKTQP----ESKCPELLANYC---- 412
+FL A D+ ++ V I KLE LK V + QP +++ E LAN+
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLK---VVPRFQPISEHQTREVEQLANHLKEKT 2122
Query: 413 ----DMLLRKTPLSKKLTS-----EEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLI 463
++LL K L + + E++E +++E+ L K K L+ +
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQ 2182
Query: 464 LDISADS---------EIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMH 514
L D+ +EE + ++ E+ + V +L M +I+ E + +E+
Sbjct: 2183 LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL-HMQLEIQKKESTTR-LQELE 2240
Query: 515 KNNKLALP-ADSVNIKILNAGAWSRSSEKV----FVSLPTELEDLIPEVEEFYKKNHSGR 569
+ NKL + + + I + A S + V F + E E I ++ E K
Sbjct: 2241 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2300
Query: 570 KLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAE 629
K+ N +I KNE+ + DLE L +R RE+ E L E E
Sbjct: 2301 KI----TTDNKVIEEKNELIR-DLETQIECLMSDQECVKRNREE-EIEQLNEVIEKLQQE 2354
Query: 630 L----RRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGK 685
L ++T + + + + V + K E + + N+E + +KN + K
Sbjct: 2355 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2414
Query: 686 INLIGRLQLTTERMRE 701
+N + + + +R RE
Sbjct: 2415 MNQLTQELFSLKRERE 2430
Score = 33.9 bits (76), Expect = 0.60
Identities = 115/603 (19%), Positives = 222/603 (36%), Gaps = 134/603 (22%)
Query: 89 LLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIF 148
L +A +VE RK F + KP LE+ L ++ D+I RK E
Sbjct: 2156 LEQALLVEDRKHFGAVEA--KPELSLEVQLQAER---------DAIDRK-------EKEI 2197
Query: 149 SNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLD 208
+N++ +L+ +L + + QL I +ES L E + ++++D+ EK L
Sbjct: 2198 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL-QELEQENKLFKDDMEKLGLA 2256
Query: 209 STERFYRTQAPSYL---------------------QQNGVQNYMKYA-DAKLKEEEKRAL 246
E + ++ Q +Q +K D K+ EE+ +
Sbjct: 2257 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2316
Query: 247 RYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNG 306
R LET+ EC L Q +KRN E++ + +++K+
Sbjct: 2317 RDLETQIEC----------------------LMSDQECVKRNREEEIEQLNEVIEKLQQE 2354
Query: 307 IEPMLK-------------DLEEHIISAGLADMVAAAETITTDSEK--YVEQLLTLFN-R 350
+ + + D +H + +A+ +A + + T +E+ +++ +L N +
Sbjct: 2355 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2414
Query: 351 FSKLVKEAF----------------------------QDDPRF-LTARDKAYKAVVNDAT 381
++L +E F +D P + + A K++ N T
Sbjct: 2415 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ-T 2473
Query: 382 IFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVL 441
FK ++ G G E++ +L + L T K++ + + + + +L
Sbjct: 2474 YFK---SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2530
Query: 442 KYVQNKDVFMRYHKAHLTRRLILDI------------SADSEIEENMVE---WLREVGMP 486
K V + + A L ++ L+ + SE E ++ LRE +
Sbjct: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2590
Query: 487 ADY------VNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSS 540
+D +++L ++ S L + E+ + N L + ++ L G +
Sbjct: 2591 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650
Query: 541 EKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQL 600
EK P ++E L E F+ SG L + + T K E+ Y + Q
Sbjct: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT-KAELASYKEKAEKLQE 2709
Query: 601 AVL 603
+L
Sbjct: 2710 ELL 2712
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 33.9 bits (76), Expect = 0.60
Identities = 72/313 (23%), Positives = 127/313 (40%), Gaps = 56/313 (17%)
Query: 192 EDKLQIYRDNFEKAY---LDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE-EEKRALR 247
++KL ++ F +A L++ F + Q + +QQ ++N + Y LK EE + L
Sbjct: 876 QEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ--MENEIHYLQENLKSMEEIQGLT 933
Query: 248 YLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGI 307
L+ + EA E KE ILA+ + + K+ + E + G+
Sbjct: 934 DLQLQ------EADEE----------KERILAQLRELEKKKKLEDAKSQEQVF-----GL 972
Query: 308 EPMLKDLEEHIISAGLADMVAAAE-TITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFL 366
+ LK L++ + ++ D +A AE TI D K + + N+ E Q+ RF
Sbjct: 973 DKELKKLKKAVATS---DKLATAELTIAKDQLKSLHGTVMKINQERA---EELQEAERFS 1026
Query: 367 TARDKAYKAVVN-DATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKL 425
+A + + +A I L+ L+QKG + + E AN +L L++ +
Sbjct: 1027 RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGAN--SQVLEIEKLNETM 1084
Query: 426 TSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGM 485
+ E + +L L NK F + E + E REV
Sbjct: 1085 ERQRTEIARLQNVLDLTGSDNKGGF-------------------ENVLEEIAELRREVSY 1125
Query: 486 PADYVNKLARMFQ 498
DY++ +A F+
Sbjct: 1126 QNDYISSMADPFK 1138
Score = 32.3 bits (72), Expect = 1.7
Identities = 139/657 (21%), Positives = 264/657 (40%), Gaps = 89/657 (13%)
Query: 149 SNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPED----KLQIYRDNFEK 204
S K +L + KL + E + + ++ES V L + + K Q+ E
Sbjct: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEM 1596
Query: 205 AYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECN---SVEAL 261
A LD + ++ + LQ + VQ AK +E L E +CN V++L
Sbjct: 1597 AVLDR-QLGHKKEELHLLQGSMVQ-------AKADLQEALRLGETEVTEKCNHIREVKSL 1648
Query: 262 MECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISA 321
+E SF++ E I +T+ L L+ ++K ++ +L+ + +H
Sbjct: 1649 LE------ELSFQK---GELNVQISERKTQ-LTLIKQEIEKEEENLQVVLRQMSKHKTEL 1698
Query: 322 GLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDAT 381
K + +L L N + +K Q D R ++ +K AV+ +
Sbjct: 1699 -----------------KNILDMLQLENHELQGLK--LQHDQR-VSELEKTQVAVLEE-- 1736
Query: 382 IFKLELP-LKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTS-EEIEAKLKEVLL 439
KLEL L+Q K + E + +LL + R T S+ L S E +K KE L
Sbjct: 1737 --KLELENLQQISQQQKGEIEWQ-KQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ 1793
Query: 440 VLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL----REVGMPADYVNK-LA 494
+ D++ + K T+R++ +S++E++ +E L R++ D +N+
Sbjct: 1794 -----EKCDIWEK--KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKL 1846
Query: 495 RMFQDIKVSEDLNQAFKEMHKN--NKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELE 552
+ DI + Q +E + +LA D +N+ + + + V +S T L+
Sbjct: 1847 SLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL-LHTTKHQDVLLSEQTRLQ 1905
Query: 553 DLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPRE 612
I E ++ + L +NE+ + L++ ++ +R E
Sbjct: 1906 KDISEWANRFEDCQKEEETKQQQLQ-----VLQNEIEENKLKLVQQEMMFQRLQKERESE 1960
Query: 613 KISFENLKLATELPDAELRRTLWSLVA-FPKLKRQVLLYEPQVNSPKD------FTEGTL 665
+ E K+ + +L + L + ++ +VL E +V + ++ E TL
Sbjct: 1961 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTL 2020
Query: 666 FSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREE----ENEGIVQLRILRTQEAIIQ 721
++ S + V+K G++ LQ + MR + N+ + + + Q A +
Sbjct: 2021 SQTKRQLSEREQQLVEKSGELLA---LQKEADSMRADFSLLRNQFLTERKKAEKQVASL- 2076
Query: 722 IMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIY 778
K KI +QL+ L+E + QK+M ++ H+ RR ++N Y
Sbjct: 2077 --KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQY 2131
>gi|37202123 NMDA receptor regulated 2 isoform a [Homo sapiens]
Length = 982
Score = 33.5 bits (75), Expect = 0.78
Identities = 33/135 (24%), Positives = 63/135 (46%), Gaps = 7/135 (5%)
Query: 191 PEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAK--LKEEEKRALRY 248
P + + +++Y+D ++ + A S +Y++Y D K + EE L++
Sbjct: 93 PYPRFSRFSQREQRSYVDLLVKYAKIPANSKAVGINKNDYLQYLDMKKHVNEEVTEFLKF 152
Query: 249 LETRRECNSVEALMECCVNALVTSFKETILAECQGMIKR-NETEKLHLMFSLMDKVPNGI 307
L+ + + + M ++ F E IL C +K+ +E LH + SLM P +
Sbjct: 153 LQNSAKKCAQDYNM---LSDDARLFTEKILRACIEQVKKYSEFYTLHEVTSLMGFFPFRV 209
Query: 308 EPMLKDLEEHIISAG 322
E LK LE+ +++ G
Sbjct: 210 EMGLK-LEKTLLALG 223
>gi|151101140 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 32.7 bits (73), Expect = 1.3
Identities = 72/388 (18%), Positives = 151/388 (38%), Gaps = 71/388 (18%)
Query: 388 PLKQKGV-GLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQN 446
P+ Q+G+ G+KT + ++L + L ++ +S+ T E+ K + + Y Q
Sbjct: 71 PVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTT--EVNKLQKGIEM---YNQE 125
Query: 447 KDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDL 506
V++ Y K T + EI+E G ADY + ++ + ++ E +
Sbjct: 126 NSVYLSYEKRAETLAV--------EIKELQ-------GQLADYNMLVDKLNTNTEMEEVM 170
Query: 507 NQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNH 566
N +N++ D + + ++ EK S+ E+E ++ K
Sbjct: 171 NDYNMLKAQNDRETQSLDVIFTE-------RQAKEKQIRSVEEEIEQEKQATDDIIKN-- 221
Query: 567 SGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELP 626
++F+N+V +++ T +L Q+ + + + L E+
Sbjct: 222 ---------------MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
Query: 627 DAELRRTLW----SLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSV---NQEFSLIKNAK 679
+++++ L + Q++ + + SP + E L + NQE + ++
Sbjct: 267 HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQL 326
Query: 680 VQKRGKINL----IGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQ 735
+ KIN I +L + E + E N+ + +++K+ +
Sbjct: 327 TDTKEKINQFIEEIRQLDMDLEEHQGEMNQ---------------KYKELKKREEHMDTF 371
Query: 736 TELVEILKNMFLPQKKMIKEQIEWLIEH 763
E E KN L +K I+ I L+EH
Sbjct: 372 IETFEETKNQELKRKAQIEANIVALLEH 399
>gi|151105223 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 32.7 bits (73), Expect = 1.3
Identities = 72/388 (18%), Positives = 151/388 (38%), Gaps = 71/388 (18%)
Query: 388 PLKQKGV-GLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQN 446
P+ Q+G+ G+KT + ++L + L ++ +S+ T E+ K + + Y Q
Sbjct: 71 PVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTT--EVNKLQKGIEM---YNQE 125
Query: 447 KDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDL 506
V++ Y K T + EI+E G ADY + ++ + ++ E +
Sbjct: 126 NSVYLSYEKRAETLAV--------EIKELQ-------GQLADYNMLVDKLNTNTEMEEVM 170
Query: 507 NQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNH 566
N +N++ D + + ++ EK S+ E+E ++ K
Sbjct: 171 NDYNMLKAQNDRETQSLDVIFTE-------RQAKEKQIRSVEEEIEQEKQATDDIIKN-- 221
Query: 567 SGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELP 626
++F+N+V +++ T +L Q+ + + + L E+
Sbjct: 222 ---------------MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
Query: 627 DAELRRTLW----SLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSV---NQEFSLIKNAK 679
+++++ L + Q++ + + SP + E L + NQE + ++
Sbjct: 267 HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQL 326
Query: 680 VQKRGKINL----IGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQ 735
+ KIN I +L + E + E N+ + +++K+ +
Sbjct: 327 TDTKEKINQFIEEIRQLDMDLEEHQGEMNQ---------------KYKELKKREEHMDTF 371
Query: 736 TELVEILKNMFLPQKKMIKEQIEWLIEH 763
E E KN L +K I+ I L+EH
Sbjct: 372 IETFEETKNQELKRKAQIEANIVALLEH 399
>gi|151105229 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 32.7 bits (73), Expect = 1.3
Identities = 72/388 (18%), Positives = 151/388 (38%), Gaps = 71/388 (18%)
Query: 388 PLKQKGV-GLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQN 446
P+ Q+G+ G+KT + ++L + L ++ +S+ T E+ K + + Y Q
Sbjct: 71 PVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTT--EVNKLQKGIEM---YNQE 125
Query: 447 KDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDL 506
V++ Y K T + EI+E G ADY + ++ + ++ E +
Sbjct: 126 NSVYLSYEKRAETLAV--------EIKELQ-------GQLADYNMLVDKLNTNTEMEEVM 170
Query: 507 NQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNH 566
N +N++ D + + ++ EK S+ E+E ++ K
Sbjct: 171 NDYNMLKAQNDRETQSLDVIFTE-------RQAKEKQIRSVEEEIEQEKQATDDIIKN-- 221
Query: 567 SGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELP 626
++F+N+V +++ T +L Q+ + + + L E+
Sbjct: 222 ---------------MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
Query: 627 DAELRRTLW----SLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSV---NQEFSLIKNAK 679
+++++ L + Q++ + + SP + E L + NQE + ++
Sbjct: 267 HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQL 326
Query: 680 VQKRGKINL----IGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQ 735
+ KIN I +L + E + E N+ + +++K+ +
Sbjct: 327 TDTKEKINQFIEEIRQLDMDLEEHQGEMNQ---------------KYKELKKREEHMDTF 371
Query: 736 TELVEILKNMFLPQKKMIKEQIEWLIEH 763
E E KN L +K I+ I L+EH
Sbjct: 372 IETFEETKNQELKRKAQIEANIVALLEH 399
>gi|100814339 coiled-coil domain containing 146 [Homo sapiens]
Length = 955
Score = 32.7 bits (73), Expect = 1.3
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 24/131 (18%)
Query: 642 KLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMRE 701
K++ Q+L Y+ + N+ K+ +EF K KI ++ + T+
Sbjct: 122 KMREQLLKYQNEYNAVKE----------REFHNQYRLNSLKEEKIIIVKEFEKITKPGEM 171
Query: 702 EENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQ--IEW 759
E+ +++ILR ++ M+KK+ L+ +L QK+++KEQ +E
Sbjct: 172 EK-----KMKILRESTEELRKEIMQKKLEIKNLREDLAS-------KQKQLLKEQKELEE 219
Query: 760 LIEHKYIRRDE 770
L+ H+ + +DE
Sbjct: 220 LLGHQVVLKDE 230
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 32.0 bits (71), Expect = 2.3
Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 18/97 (18%)
Query: 694 LTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEIL---------KN 744
LT E E EN +R R QE +++I ++R+++S A + E +E +
Sbjct: 11 LTPEERMELEN-----IR-RRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRK 64
Query: 745 MFLPQKKMI---KEQIEWLIEHKYIRRDESDINTFIY 778
M + +KK K+ I++L+E++ ++ +I F+Y
Sbjct: 65 MAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLY 101
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 32.0 bits (71), Expect = 2.3
Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 18/97 (18%)
Query: 694 LTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEIL---------KN 744
LT E E EN +R R QE +++I ++R+++S A + E +E +
Sbjct: 11 LTPEERMELEN-----IR-RRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRK 64
Query: 745 MFLPQKKMI---KEQIEWLIEHKYIRRDESDINTFIY 778
M + +KK K+ I++L+E++ ++ +I F+Y
Sbjct: 65 MAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLY 101
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 31.6 bits (70), Expect = 3.0
Identities = 29/114 (25%), Positives = 57/114 (50%), Gaps = 12/114 (10%)
Query: 639 AFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTER 698
AF + K++V +V + ++ E L + +E N ++Q+R + L++ E+
Sbjct: 369 AFQQYKKKVAEKLEKVQAEEEILERNLTNCEKE-----NKRLQERCGLYK-SELEILKEK 422
Query: 699 MR---EEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELV---EILKNMF 746
+R EE N G +LRI+ + + + + S +L++EL EIL++ F
Sbjct: 423 LRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKF 476
Score = 31.2 bits (69), Expect = 3.9
Identities = 101/471 (21%), Positives = 186/471 (39%), Gaps = 82/471 (17%)
Query: 114 LEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKL------VHAER 167
L+ L +G KK N++ K + + +E IK R DSA+++ +H +
Sbjct: 808 LDRLLTESKGEMKKENMKKDEALKALQNQVSEE---TIKVRQLDSALEICKEELVLHLNQ 864
Query: 168 LG---EAFDSQLVIGVRESYVNLCSNPEDKLQ---IYRDNFEKAYLDSTERFYRTQAPSY 221
L E F+ QL E Y C E K++ + + + L T + Q
Sbjct: 865 LEGNKEKFEKQLKKKSEEVY---CLQKELKIKNHSLQETSEQNVILQHTLQ----QQQQM 917
Query: 222 LQQNGVQN-YMKYADAKLKEEEKRALRYLETRRECNS--VEALMECCVNAL-VTSFKETI 277
LQQ ++N ++ KL+++ + + L+ +RE ++ + + E C +A K
Sbjct: 918 LQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQK 977
Query: 278 LAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDS 337
+ E G ++ + E L K+ I + +D E + DM+ + T+
Sbjct: 978 VIELTGTARQVKIEMDQYKEEL-SKMEKEIMHLKRDGENKAMHLSQLDMIL--DQTKTEL 1034
Query: 338 EKY---VEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGV 394
EK V++L L + + EA Q T A+ +L+ L+Q
Sbjct: 1035 EKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHG---------ELKSTLRQL-- 1083
Query: 395 GLKTQPESKCPELLANYCDMLLRKTPLSKKLTSE------EIEAKLKEVLLVLKYVQNKD 448
+ ++L L K K LT+E EIE K +E+L + + ++ ++
Sbjct: 1084 -------QELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERN 1136
Query: 449 VFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQ 508
++ A +T D I E+ E +++ IK+ L +
Sbjct: 1137 WELKQRAAQVTH-------LDMTIREHRGEMEQKI----------------IKLEGTLEK 1173
Query: 509 AFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVE 559
+ E+ + NK +S+N K+ NA R E + + E+ L E+E
Sbjct: 1174 SELELKECNK---QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE 1221
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 31.6 bits (70), Expect = 3.0
Identities = 55/287 (19%), Positives = 117/287 (40%), Gaps = 54/287 (18%)
Query: 286 KRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLL 345
+++ TE + + DK+ + + +++L++H SAG + M+ + ++T ++ + +
Sbjct: 513 RQHNTEIRMAVSKVADKMDH-LMTKVEELQKH--SAGNS-MLIPSMSVTMETSMIMSNIQ 568
Query: 346 TLFNRFSKLVKEAFQDDPRFLTARDKAYKAVV-NDATIFKLELPLKQKGVGLKTQPESKC 404
+ +L +E + R DK + + N + + L ++++ L+T E+
Sbjct: 569 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQ 628
Query: 405 PELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLIL 464
+L K +EE+ A +V +HL ++
Sbjct: 629 ARVL---------HAEQEKAKVTEELAAATAQV------------------SHLQLKMTA 661
Query: 465 DISADSEIEENMVEWLREVGMPADYVNKL-ARMFQDIKVSEDLNQAFKEMHKNNKLALPA 523
++E++ + E L+E + + K+ A++ + + SE FK +N K
Sbjct: 662 HQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRK----- 716
Query: 524 DSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRK 570
+ +K+ SL EL DL E +E +KN S RK
Sbjct: 717 -QLELKV--------------TSLEEELTDLRVE-KESLEKNLSERK 747
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,534,035
Number of Sequences: 37866
Number of extensions: 1121723
Number of successful extensions: 3734
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 3627
Number of HSP's gapped (non-prelim): 151
length of query: 780
length of database: 18,247,518
effective HSP length: 110
effective length of query: 670
effective length of database: 14,082,258
effective search space: 9435112860
effective search space used: 9435112860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.