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Search of human proteins with 40254434
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40254434 phosphodiesterase 3B [Homo sapiens]
(1112 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40254434 phosphodiesterase 3B [Homo sapiens] 2293 0.0
gi|70608155 phosphodiesterase 3A [Homo sapiens] 796 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 188 3e-47
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 188 3e-47
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 183 9e-46
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 183 9e-46
gi|4826894 phosphodiesterase 1C [Homo sapiens] 181 3e-45
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 181 4e-45
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 181 4e-45
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 181 4e-45
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 181 4e-45
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 178 3e-44
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 178 3e-44
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 178 3e-44
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 178 3e-44
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 170 8e-42
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 170 8e-42
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 170 8e-42
gi|4505677 phosphodiesterase 1B [Homo sapiens] 167 4e-41
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 149 1e-35
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 149 1e-35
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 149 1e-35
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 149 1e-35
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 149 1e-35
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 144 6e-34
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 144 6e-34
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 140 7e-33
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 130 9e-30
gi|9506959 phosphodiesterase 7B [Homo sapiens] 128 3e-29
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 120 5e-27
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 2293 bits (5941), Expect = 0.0
Identities = 1112/1112 (100%), Positives = 1112/1112 (100%)
Query: 1 MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELR 60
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELR
Sbjct: 1 MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELR 60
Query: 61 PPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLS 120
PPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLS
Sbjct: 61 PPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLS 120
Query: 121 PLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD 180
PLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD
Sbjct: 121 PLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD 180
Query: 181 AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSL 240
AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSL
Sbjct: 181 AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSL 240
Query: 241 PSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSL 300
PSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSL
Sbjct: 241 PSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSL 300
Query: 301 GETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR 360
GETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR
Sbjct: 301 GETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR 360
Query: 361 NMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKG 420
NMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKG
Sbjct: 361 NMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKG 420
Query: 421 DRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGP 480
DRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGP
Sbjct: 421 DRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGP 480
Query: 481 FNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDT 540
FNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDT
Sbjct: 481 FNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDT 540
Query: 541 ADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSG 600
ADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSG
Sbjct: 541 ADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSG 600
Query: 601 KSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLD 660
KSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLD
Sbjct: 601 KSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLD 660
Query: 661 LILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF 720
LILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF
Sbjct: 661 LILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF 720
Query: 721 MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRIN 780
MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRIN
Sbjct: 721 MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRIN 780
Query: 781 HGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQ 840
HGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQ
Sbjct: 781 HGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQ 840
Query: 841 AVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD 900
AVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD
Sbjct: 841 AVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD 900
Query: 901 FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY 960
FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY
Sbjct: 901 FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY 960
Query: 961 EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDN 1020
EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDN
Sbjct: 961 EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDN 1020
Query: 1021 DTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEE 1080
DTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEE
Sbjct: 1021 DTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEE 1080
Query: 1081 KCKADGNKLQVENSSLPQADEIQVIEEADEEE 1112
KCKADGNKLQVENSSLPQADEIQVIEEADEEE
Sbjct: 1081 KCKADGNKLQVENSSLPQADEIQVIEEADEEE 1112
>gi|70608155 phosphodiesterase 3A [Homo sapiens]
Length = 1141
Score = 796 bits (2056), Expect = 0.0
Identities = 486/1034 (47%), Positives = 643/1034 (62%), Gaps = 86/1034 (8%)
Query: 122 LFSIACAFFFLTCFLTRTK-RGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD 180
LFS+ CAFF++ +L R R P +AL A C G+ LV
Sbjct: 136 LFSLLCAFFWMGLYLLRAGVRLP---------LAVALLAACCGGEALV---------QIG 177
Query: 181 AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSL 240
G H AAG +VLSC+ L LRLR VL++ L S V VS SL
Sbjct: 178 LGVGEDHLLSLPAAG---VVLSCLAAATWLV--LRLRLGVLMIALTSAVRTVSLISLERF 232
Query: 241 PSALRPLLSGLVGGAGCLLALGLDHFF-QIREAP----LHPRLSSAAEEKVPVIRPRRRS 295
A RP L+ L G G LLA ++ Q EA L +L + +E +PV + RRRS
Sbjct: 233 KVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRS 292
Query: 296 SCVSLGETAASYYGSCKIFRRPSLPCISREQMILW-DWDLKQWYKPHYQNSGGGNGVDLS 354
S V E + S K RR SLPCI REQ++ +WD K+ + Q+SG VD++
Sbjct: 293 SSVVSAEMSGC---SSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGS-QSSGTSITVDIA 348
Query: 355 VLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGA---FSGSCRPKINPLTPFPGFYPCS 411
V+ EA +++DLL DPSLPP V +SLR++S+L+ F +P++NP+T Y CS
Sbjct: 349 VMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCS 408
Query: 412 EIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGT-------SGLLPVEQSS-RWDRNNGKR 463
+ E+ +EK + K L R SLP LRR S T +GL +E + R DR+ +
Sbjct: 409 DSEESSEKDKLAIPKRLRR-SLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIK 467
Query: 464 PHQEFGISSQGCYLNGPFNSNLLTIPKQRSSS----VSLTHHVGLR---RAGVLSSLSPV 516
QE SS + N P ++T+ K RS + +S +HV + R G L+ +SP+
Sbjct: 468 L-QEAPSSSPDSW-NNPV---MMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPL 522
Query: 517 NSSNHGPVS---TGSLTNR-SPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSD 572
+S P+ SL ++ S ++FP++AD K S+ R+L + PD Q+
Sbjct: 523 SSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPP 582
Query: 573 SNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRK 632
+C+SCG S+ + D +SG S+ T E DS
Sbjct: 583 V-ICSSCGRPY------SQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSD 635
Query: 633 LFQEGDKW--LTEEAQSEQQTNI---EQEVSLDL-------ILVEEYDSLIEKMSNWNFP 680
+ Q D+ L E + + E + LD ++++ DS++E+++ WNFP
Sbjct: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
Query: 681 IFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRI 740
IF+LVE +G K GRILSQV Y LF+D GL E FKIP ++FMNYF ALE GYRDIPYHNRI
Sbjct: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
Query: 741 HATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYG 800
HATDVLHAVWYLTT+P+PGL + N G+ +++DSD HG + Y+ SK+ + D+ YG
Sbjct: 756 HATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYG 815
Query: 801 CLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWN 860
CLS NIPALELMALYVAAAMHDYDHPGRTNAFLVAT+APQAVLYNDRSVLENHHAA+AWN
Sbjct: 816 CLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWN 875
Query: 861 LYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWS 920
L++SRPEYNFL++LDHVEFK FRFLVIEAILATDLKKHFDF+A+FN K ND GI+W+
Sbjct: 876 LFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVND--DVGIDWT 933
Query: 921 NENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRS 980
NENDRLLVCQ+CIKLADINGPAK ++LHL+WT+GIVNEFYEQGDEEA+LGLPISPFMDRS
Sbjct: 934 NENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRS 993
Query: 981 SPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLE-AEEDNDTESGDDEDGE-ELDTEDE 1038
+PQLA LQESFI+HIVGPLCNSYD+AGL+PG+W+E ++E DT+ ++E+ E E+E
Sbjct: 994 APQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEE 1053
Query: 1039 EMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQ 1098
ENN +PK K RR+I+CQ+ HL +NHK+WK+++EEE++ N+ +
Sbjct: 1054 TCENNESPKKKTFK-RRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHS 1112
Query: 1099 ADEIQVIEEADEEE 1112
+++IQ I+E +EE+
Sbjct: 1113 SEQIQAIKEEEEEK 1126
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 188 bits (477), Expect = 3e-47
Identities = 158/568 (27%), Positives = 254/568 (44%), Gaps = 98/568 (17%)
Query: 567 QLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESF--KLMETQQEEE 624
Q R+S S + ++ +ML T S+ +SG + + F +F K E +
Sbjct: 295 QTRHSVSEMASNKFKRMLNRELTHLSE-----MSRSGNQVSEFISNTFLDKQHEVEIPSP 349
Query: 625 TEK-KDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMSNWNFP 680
T+K K+ +K + + S TN + + E+ D L +E ++ W
Sbjct: 350 TQKEKEKKKRPMSQISGVKKLMHSSSLTN--SSIPRFGVKTEQEDVLAKELEDVNKWGLH 407
Query: 681 IFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DIPYHNR 739
+F + E G R L+ +M+T+FQ+ LL+ FKIP + Y LE+ Y D+ YHN
Sbjct: 408 VFRIAELSGN---RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNN 464
Query: 740 IHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESY 799
IHA DV+ + L + P
Sbjct: 465 IHAADVVQSTHVLLSTPA------------------------------------------ 482
Query: 800 GCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAW 859
L + LE++A A+A+HD DHPG +N FL+ TN+ A++YND SVLENHH A +
Sbjct: 483 --LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 540
Query: 860 NLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDVNSNGI 917
L L + +L + + R +VI+ +LATD+ KH + LA+ + V S+G+
Sbjct: 541 KL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV 599
Query: 918 EW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPF 976
N +DR+ V Q + AD++ P K L+ +WT+ I+ EF+ QGD E G+ ISP
Sbjct: 600 LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPM 659
Query: 977 MDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLLP-----GQWLEA--EEDNDTE 1023
D+ + + K Q FI +IV PL ++ DA +L +W ++ +
Sbjct: 660 CDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPA 719
Query: 1024 SGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCK 1083
D E+G + TE + E L ++ K VEE+ C
Sbjct: 720 PDDPEEGRQGQTEKFQFELTLEEDGE----------------SDTEKDSGSQVEEDTSC- 762
Query: 1084 ADGNKLQVENSSLPQADEIQVIEEADEE 1111
+D L ++S ++ EI + E+ +EE
Sbjct: 763 SDSKTLCTQDS---ESTEIPLDEQVEEE 787
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 188 bits (477), Expect = 3e-47
Identities = 158/568 (27%), Positives = 254/568 (44%), Gaps = 98/568 (17%)
Query: 567 QLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESF--KLMETQQEEE 624
Q R+S S + ++ +ML T S+ +SG + + F +F K E +
Sbjct: 159 QTRHSVSEMASNKFKRMLNRELTHLSE-----MSRSGNQVSEFISNTFLDKQHEVEIPSP 213
Query: 625 TEK-KDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMSNWNFP 680
T+K K+ +K + + S TN + + E+ D L +E ++ W
Sbjct: 214 TQKEKEKKKRPMSQISGVKKLMHSSSLTN--SSIPRFGVKTEQEDVLAKELEDVNKWGLH 271
Query: 681 IFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DIPYHNR 739
+F + E G R L+ +M+T+FQ+ LL+ FKIP + Y LE+ Y D+ YHN
Sbjct: 272 VFRIAELSGN---RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNN 328
Query: 740 IHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESY 799
IHA DV+ + L + P
Sbjct: 329 IHAADVVQSTHVLLSTPA------------------------------------------ 346
Query: 800 GCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAW 859
L + LE++A A+A+HD DHPG +N FL+ TN+ A++YND SVLENHH A +
Sbjct: 347 --LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 404
Query: 860 NLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDVNSNGI 917
L L + +L + + R +VI+ +LATD+ KH + LA+ + V S+G+
Sbjct: 405 KL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV 463
Query: 918 EW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPF 976
N +DR+ V Q + AD++ P K L+ +WT+ I+ EF+ QGD E G+ ISP
Sbjct: 464 LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPM 523
Query: 977 MDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLLP-----GQWLEA--EEDNDTE 1023
D+ + + K Q FI +IV PL ++ DA +L +W ++ +
Sbjct: 524 CDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPA 583
Query: 1024 SGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCK 1083
D E+G + TE + E L ++ K VEE+ C
Sbjct: 584 PDDPEEGRQGQTEKFQFELTLEEDGE----------------SDTEKDSGSQVEEDTSC- 626
Query: 1084 ADGNKLQVENSSLPQADEIQVIEEADEE 1111
+D L ++S ++ EI + E+ +EE
Sbjct: 627 SDSKTLCTQDS---ESTEIPLDEQVEEE 651
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 183 bits (464), Expect = 9e-46
Identities = 117/330 (35%), Positives = 163/330 (49%), Gaps = 58/330 (17%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
++ + W+F +F L E GE S L ++Y LF L+ FKIP + + ALE G
Sbjct: 154 LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
Query: 731 YRDI--PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y PYHN IHA DV V Y+ +H G I H
Sbjct: 211 YSKYKNPYHNLIHAADVTQTVHYI---------MLHTG------------IMHW------ 243
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+ LE++A+ AAA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 244 -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLENHH ++A+ L + E N L++L +++ R LVIE +L+TD+ HF +
Sbjct: 287 VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIR-- 343
Query: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
N ++ DR + + ADI+ PAK LH +WT ++ EF+ QGD+EA
Sbjct: 344 ------NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAE 397
Query: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP 998
LGLP SP DR S +A+ Q FI IV P
Sbjct: 398 LGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 183 bits (464), Expect = 9e-46
Identities = 117/330 (35%), Positives = 163/330 (49%), Gaps = 58/330 (17%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
++ + W+F +F L E GE S L ++Y LF L+ FKIP + + ALE G
Sbjct: 154 LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
Query: 731 YRDI--PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y PYHN IHA DV V Y+ +H G I H
Sbjct: 211 YSKYKNPYHNLIHAADVTQTVHYI---------MLHTG------------IMHW------ 243
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+ LE++A+ AAA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 244 -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLENHH ++A+ L + E N L++L +++ R LVIE +L+TD+ HF +
Sbjct: 287 VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIR-- 343
Query: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
N ++ DR + + ADI+ PAK LH +WT ++ EF+ QGD+EA
Sbjct: 344 ------NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAE 397
Query: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP 998
LGLP SP DR S +A+ Q FI IV P
Sbjct: 398 LGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 181 bits (459), Expect = 3e-45
Identities = 131/455 (28%), Positives = 203/455 (44%), Gaps = 74/455 (16%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
++ + W+F +F L E G+ + L + Y L L+ FKIP +++ ALE G
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHA---LKFIFYELLTRYDLISRFKIPISALVSFVEALEVG 219
Query: 731 Y--RDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y PYHN +HA DV V YL + TG
Sbjct: 220 YSKHKNPYHNLMHAADVTQTVHYLLYK-------------TG------------------ 248
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+++ + LE+ A+ +AA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 249 -------------VANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRS 295
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLENHH ++A+ L E N L++L +++ FR LVIE ++ATD+ HF +
Sbjct: 296 VLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAM--- 352
Query: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
++ ++ + + ADI+ PAK DLH +WT ++ EF+ QGD EA
Sbjct: 353 -----KTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAE 407
Query: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP------------LCNSYDAAGLLPGQWLEA 1016
LGLP SP DR S +A+ Q FI IV P + D G
Sbjct: 408 LGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRR 467
Query: 1017 EEDNDTESGD-DEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEI 1075
N S D G + + N + KS + + +++H N + W+
Sbjct: 468 SSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVH---INRERWRAK 524
Query: 1076 VEEEEKCKADGNKLQVENSSLPQADEIQVIEEADE 1110
V +EEK K + + + ++ Q E++ +A+E
Sbjct: 525 VPKEEKAKKEAEE-KARLAAEEQQKEMEAKSQAEE 558
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 181 bits (458), Expect = 4e-45
Identities = 120/392 (30%), Positives = 187/392 (47%), Gaps = 60/392 (15%)
Query: 619 TQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMS 675
TQ++ E +KK G K L + + +S + E D L +E ++
Sbjct: 292 TQKDREKKKKQQLMTQISGVKKLMHSSSLNNTS-----ISRFGVNTENEDHLAKELEDLN 346
Query: 676 NWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DI 734
W IF + G R L+ +MY +FQ+ LL+ F+I + F+ Y LE+ Y D+
Sbjct: 347 KWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV 403
Query: 735 PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSN 794
YHN +HA DV + L + P
Sbjct: 404 AYHNSLHAADVAQSTHVLLSTPA------------------------------------- 426
Query: 795 PDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 854
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SVLENHH
Sbjct: 427 -------LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 479
Query: 855 AASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDV 912
A + L L + ++L + + R +VI+ +LATD+ KH LA+ + V
Sbjct: 480 LAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 538
Query: 913 NSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGL 971
S+G+ N DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD+E G+
Sbjct: 539 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 598
Query: 972 PISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
ISP D+ + + K Q FI +IV PL ++
Sbjct: 599 EISPMCDKHTASVEKSQVGFIDYIVHPLWETW 630
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 181 bits (458), Expect = 4e-45
Identities = 120/392 (30%), Positives = 187/392 (47%), Gaps = 60/392 (15%)
Query: 619 TQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMS 675
TQ++ E +KK G K L + + +S + E D L +E ++
Sbjct: 277 TQKDREKKKKQQLMTQISGVKKLMHSSSLNNTS-----ISRFGVNTENEDHLAKELEDLN 331
Query: 676 NWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DI 734
W IF + G R L+ +MY +FQ+ LL+ F+I + F+ Y LE+ Y D+
Sbjct: 332 KWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV 388
Query: 735 PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSN 794
YHN +HA DV + L + P
Sbjct: 389 AYHNSLHAADVAQSTHVLLSTPA------------------------------------- 411
Query: 795 PDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 854
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SVLENHH
Sbjct: 412 -------LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 464
Query: 855 AASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDV 912
A + L L + ++L + + R +VI+ +LATD+ KH LA+ + V
Sbjct: 465 LAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 523
Query: 913 NSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGL 971
S+G+ N DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD+E G+
Sbjct: 524 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 583
Query: 972 PISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
ISP D+ + + K Q FI +IV PL ++
Sbjct: 584 EISPMCDKHTASVEKSQVGFIDYIVHPLWETW 615
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 181 bits (458), Expect = 4e-45
Identities = 120/392 (30%), Positives = 187/392 (47%), Gaps = 60/392 (15%)
Query: 619 TQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMS 675
TQ++ E +KK G K L + + +S + E D L +E ++
Sbjct: 120 TQKDREKKKKQQLMTQISGVKKLMHSSSLNNTS-----ISRFGVNTENEDHLAKELEDLN 174
Query: 676 NWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DI 734
W IF + G R L+ +MY +FQ+ LL+ F+I + F+ Y LE+ Y D+
Sbjct: 175 KWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV 231
Query: 735 PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSN 794
YHN +HA DV + L + P
Sbjct: 232 AYHNSLHAADVAQSTHVLLSTPA------------------------------------- 254
Query: 795 PDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 854
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SVLENHH
Sbjct: 255 -------LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 307
Query: 855 AASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDV 912
A + L L + ++L + + R +VI+ +LATD+ KH LA+ + V
Sbjct: 308 LAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 366
Query: 913 NSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGL 971
S+G+ N DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD+E G+
Sbjct: 367 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 426
Query: 972 PISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
ISP D+ + + K Q FI +IV PL ++
Sbjct: 427 EISPMCDKHTASVEKSQVGFIDYIVHPLWETW 458
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 181 bits (458), Expect = 4e-45
Identities = 120/392 (30%), Positives = 187/392 (47%), Gaps = 60/392 (15%)
Query: 619 TQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMS 675
TQ++ E +KK G K L + + +S + E D L +E ++
Sbjct: 292 TQKDREKKKKQQLMTQISGVKKLMHSSSLNNTS-----ISRFGVNTENEDHLAKELEDLN 346
Query: 676 NWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DI 734
W IF + G R L+ +MY +FQ+ LL+ F+I + F+ Y LE+ Y D+
Sbjct: 347 KWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV 403
Query: 735 PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSN 794
YHN +HA DV + L + P
Sbjct: 404 AYHNSLHAADVAQSTHVLLSTPA------------------------------------- 426
Query: 795 PDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 854
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SVLENHH
Sbjct: 427 -------LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 479
Query: 855 AASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDV 912
A + L L + ++L + + R +VI+ +LATD+ KH LA+ + V
Sbjct: 480 LAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 538
Query: 913 NSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGL 971
S+G+ N DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD+E G+
Sbjct: 539 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 598
Query: 972 PISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
ISP D+ + + K Q FI +IV PL ++
Sbjct: 599 EISPMCDKHTASVEKSQVGFIDYIVHPLWETW 630
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 178 bits (451), Expect = 3e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 308 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 364
Query: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Y D+ YHN +HA DVL + L P
Sbjct: 365 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 392
Query: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 393 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 440
Query: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 441 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 499
Query: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 500 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 559
Query: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 560 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 596
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 178 bits (451), Expect = 3e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 343 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 399
Query: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Y D+ YHN +HA DVL + L P
Sbjct: 400 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 427
Query: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 428 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 475
Query: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 476 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 534
Query: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 535 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 594
Query: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 595 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 631
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 178 bits (451), Expect = 3e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 369 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 425
Query: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Y D+ YHN +HA DVL + L P
Sbjct: 426 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 453
Query: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 454 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 501
Query: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 502 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 560
Query: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 561 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 620
Query: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 621 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 657
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 178 bits (451), Expect = 3e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 130 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 186
Query: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Y D+ YHN +HA DVL + L P
Sbjct: 187 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 214
Query: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 215 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 262
Query: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 263 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
Query: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
Query: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 418
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 170 bits (430), Expect = 8e-42
Identities = 121/405 (29%), Positives = 185/405 (45%), Gaps = 78/405 (19%)
Query: 665 EEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYF 724
E+ +E + W +F++ E G R L+ +++++FQ+ LL+ F+IP Y
Sbjct: 212 EQLAKELEDTNKWGLDVFKVAELSGN---RPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
Query: 725 RALENGYR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGR 783
LE Y ++ YHN +HA DV + L P
Sbjct: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPA-------------------------- 302
Query: 784 IAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVL 843
L + LE++A A+A+HD DHPG +N FL+ TN+ A++
Sbjct: 303 ------------------LEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALM 344
Query: 844 YNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLA 903
YND SVLENHH A + L L + +L + R +VI+ +LATD+ KH + LA
Sbjct: 345 YNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLA 403
Query: 904 EFNA--KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY 960
+ + V S G+ N +DR+ V Q + AD++ P K L+ +WT+ I+ EF+
Sbjct: 404 DLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFF 463
Query: 961 EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLLP---- 1010
+QGD E GL ISP D+ + + K Q FI +I PL ++ DA LL
Sbjct: 464 QQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLED 523
Query: 1011 -GQWLE-------AEEDNDTESGDD--------EDGEELDTEDEE 1039
+W + ++ N G D E+ EE D E+EE
Sbjct: 524 NREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEE 568
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 170 bits (430), Expect = 8e-42
Identities = 121/405 (29%), Positives = 185/405 (45%), Gaps = 78/405 (19%)
Query: 665 EEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYF 724
E+ +E + W +F++ E G R L+ +++++FQ+ LL+ F+IP Y
Sbjct: 286 EQLAKELEDTNKWGLDVFKVAELSGN---RPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
Query: 725 RALENGYR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGR 783
LE Y ++ YHN +HA DV + L P
Sbjct: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPA-------------------------- 376
Query: 784 IAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVL 843
L + LE++A A+A+HD DHPG +N FL+ TN+ A++
Sbjct: 377 ------------------LEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALM 418
Query: 844 YNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLA 903
YND SVLENHH A + L L + +L + R +VI+ +LATD+ KH + LA
Sbjct: 419 YNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLA 477
Query: 904 EFNA--KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY 960
+ + V S G+ N +DR+ V Q + AD++ P K L+ +WT+ I+ EF+
Sbjct: 478 DLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFF 537
Query: 961 EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLLP---- 1010
+QGD E GL ISP D+ + + K Q FI +I PL ++ DA LL
Sbjct: 538 QQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLED 597
Query: 1011 -GQWLE-------AEEDNDTESGDD--------EDGEELDTEDEE 1039
+W + ++ N G D E+ EE D E+EE
Sbjct: 598 NREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEE 642
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 170 bits (430), Expect = 8e-42
Identities = 121/405 (29%), Positives = 185/405 (45%), Gaps = 78/405 (19%)
Query: 665 EEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYF 724
E+ +E + W +F++ E G R L+ +++++FQ+ LL+ F+IP Y
Sbjct: 318 EQLAKELEDTNKWGLDVFKVAELSGN---RPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
Query: 725 RALENGYR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGR 783
LE Y ++ YHN +HA DV + L P
Sbjct: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPA-------------------------- 408
Query: 784 IAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVL 843
L + LE++A A+A+HD DHPG +N FL+ TN+ A++
Sbjct: 409 ------------------LEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALM 450
Query: 844 YNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLA 903
YND SVLENHH A + L L + +L + R +VI+ +LATD+ KH + LA
Sbjct: 451 YNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLA 509
Query: 904 EFNA--KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY 960
+ + V S G+ N +DR+ V Q + AD++ P K L+ +WT+ I+ EF+
Sbjct: 510 DLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFF 569
Query: 961 EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLLP---- 1010
+QGD E GL ISP D+ + + K Q FI +I PL ++ DA LL
Sbjct: 570 QQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLED 629
Query: 1011 -GQWLE-------AEEDNDTESGDD--------EDGEELDTEDEE 1039
+W + ++ N G D E+ EE D E+EE
Sbjct: 630 NREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEE 674
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 167 bits (424), Expect = 4e-41
Identities = 110/330 (33%), Positives = 160/330 (48%), Gaps = 58/330 (17%)
Query: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
++ + W F +F L + + + L +++ L L+ FKIPT M++ ALE G
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHA---LRTIVFELLTRHNLISRFKIPTVFLMSFLDALETG 214
Query: 731 YRDI--PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y PYHN+IHA DV V R G ++
Sbjct: 215 YGKYKNPYHNQIHAADVTQTVHCFLLRT--------------------GMVH-------- 246
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
CLS +EL+A+ AAA+HDY+H G TN+F + T + A++YNDRS
Sbjct: 247 ------------CLSE----IELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRS 290
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLENHH +S + L + E N ++L EF R LVIE +LATD+ HF +
Sbjct: 291 VLENHHISSVFRL-MQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTM--- 346
Query: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
++ D+ + + ADI+ P K +H +WT+ ++ EF+ QGD+EA
Sbjct: 347 -----KTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAE 401
Query: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP 998
LGLP SP DR+S +A+ Q FI IV P
Sbjct: 402 LGLPFSPLCDRTSTLVAQSQIGFIDFIVEP 431
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 149 bits (377), Expect = 1e-35
Identities = 103/353 (29%), Positives = 165/353 (46%), Gaps = 59/353 (16%)
Query: 670 LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALEN 729
L++ +W+F IFEL E + K R L + +F G+ E +F+ +E
Sbjct: 503 LLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 730 GYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y YHN HA DVLHA + G E
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFL----------------GKER--------------- 588
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+ ++ L+ +A +AA +HD DHPGRTN+FL + AVLYND +
Sbjct: 589 -------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA 635
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLE+HH A A+ L + + N ++D ++ R +I+ +LAT++ KHF+ + +F
Sbjct: 636 VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNS 695
Query: 909 ANDVNSNGIEWSN----------ENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNE 958
N + IE S+ +++L+ ++ IK AD+ P + DL ++W I E
Sbjct: 696 INKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEE 755
Query: 959 FYEQGDEEANLGLP-ISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP 1010
++ Q DEE GLP + P DR++ + K Q SFI + + + +++DA LP
Sbjct: 756 YFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 808
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 149 bits (377), Expect = 1e-35
Identities = 103/353 (29%), Positives = 165/353 (46%), Gaps = 59/353 (16%)
Query: 670 LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALEN 729
L++ +W+F IFEL E + K R L + +F G+ E +F+ +E
Sbjct: 530 LLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 730 GYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y YHN HA DVLHA + G E
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFL----------------GKER--------------- 615
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+ ++ L+ +A +AA +HD DHPGRTN+FL + AVLYND +
Sbjct: 616 -------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA 662
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLE+HH A A+ L + + N ++D ++ R +I+ +LAT++ KHF+ + +F
Sbjct: 663 VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNS 722
Query: 909 ANDVNSNGIEWSN----------ENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNE 958
N + IE S+ +++L+ ++ IK AD+ P + DL ++W I E
Sbjct: 723 INKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEE 782
Query: 959 FYEQGDEEANLGLP-ISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP 1010
++ Q DEE GLP + P DR++ + K Q SFI + + + +++DA LP
Sbjct: 783 YFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 835
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 149 bits (377), Expect = 1e-35
Identities = 103/353 (29%), Positives = 165/353 (46%), Gaps = 59/353 (16%)
Query: 670 LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALEN 729
L++ +W+F IFEL E + K R L + +F G+ E +F+ +E
Sbjct: 495 LLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 730 GYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y YHN HA DVLHA + G E
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFL----------------GKER--------------- 580
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+ ++ L+ +A +AA +HD DHPGRTN+FL + AVLYND +
Sbjct: 581 -------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA 627
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLE+HH A A+ L + + N ++D ++ R +I+ +LAT++ KHF+ + +F
Sbjct: 628 VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNS 687
Query: 909 ANDVNSNGIEWSN----------ENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNE 958
N + IE S+ +++L+ ++ IK AD+ P + DL ++W I E
Sbjct: 688 INKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEE 747
Query: 959 FYEQGDEEANLGLP-ISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP 1010
++ Q DEE GLP + P DR++ + K Q SFI + + + +++DA LP
Sbjct: 748 YFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 800
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 149 bits (377), Expect = 1e-35
Identities = 103/353 (29%), Positives = 165/353 (46%), Gaps = 59/353 (16%)
Query: 670 LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALEN 729
L++ +W+F IFEL E + K R L + +F G+ E +F+ +E
Sbjct: 453 LLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 730 GYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y YHN HA DVLHA + G E
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFL----------------GKER--------------- 538
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+ ++ L+ +A +AA +HD DHPGRTN+FL + AVLYND +
Sbjct: 539 -------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA 585
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLE+HH A A+ L + + N ++D ++ R +I+ +LAT++ KHF+ + +F
Sbjct: 586 VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNS 645
Query: 909 ANDVNSNGIEWSN----------ENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNE 958
N + IE S+ +++L+ ++ IK AD+ P + DL ++W I E
Sbjct: 646 INKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEE 705
Query: 959 FYEQGDEEANLGLP-ISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP 1010
++ Q DEE GLP + P DR++ + K Q SFI + + + +++DA LP
Sbjct: 706 YFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 758
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 149 bits (377), Expect = 1e-35
Identities = 103/353 (29%), Positives = 165/353 (46%), Gaps = 59/353 (16%)
Query: 670 LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALEN 729
L++ +W+F IFEL E + K R L + +F G+ E +F+ +E
Sbjct: 550 LLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 730 GYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y YHN HA DVLHA + G E
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFL----------------GKER--------------- 635
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
+ ++ L+ +A +AA +HD DHPGRTN+FL + AVLYND +
Sbjct: 636 -------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA 682
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLE+HH A A+ L + + N ++D ++ R +I+ +LAT++ KHF+ + +F
Sbjct: 683 VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNS 742
Query: 909 ANDVNSNGIEWSN----------ENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNE 958
N + IE S+ +++L+ ++ IK AD+ P + DL ++W I E
Sbjct: 743 INKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEE 802
Query: 959 FYEQGDEEANLGLP-ISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP 1010
++ Q DEE GLP + P DR++ + K Q SFI + + + +++DA LP
Sbjct: 803 YFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 855
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 144 bits (362), Expect = 6e-34
Identities = 104/376 (27%), Positives = 167/376 (44%), Gaps = 64/376 (17%)
Query: 651 TNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLL 710
+NI +SLD + +E W+F IFEL + L M+ F G+
Sbjct: 427 SNIITPISLDDV-PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARF---GIC 482
Query: 711 EIFKIPTQQFMNYFRALENGYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGT 769
E ++ + +E Y PYHN H+ DVLHA
Sbjct: 483 EFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHAT-------------------- 522
Query: 770 GNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRT 829
AY SK + + ++ +A +AA +HD DHPGRT
Sbjct: 523 ---------------AYFLSKER---------IKETLDPIDEVAALIAATIHDVDHPGRT 558
Query: 830 NAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEA 889
N+FL + A+LYND +VLE+HHAA A+ L + N +++ +++ R +I+
Sbjct: 559 NSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDM 618
Query: 890 ILATDLKKHFD----FLAEFNAKANDVNSNGIEWSNE----------NDRLLVCQVCIKL 935
+LAT++ KHF+ F+ N + NG N+ +R L+ ++ IK
Sbjct: 619 VLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKC 678
Query: 936 ADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLP-ISPFMDRSSPQLAKLQESFITH 994
AD++ P + ++W I E++ Q DEE GLP + P DR++ + K Q SFI +
Sbjct: 679 ADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDY 738
Query: 995 IVGPLCNSYDAAGLLP 1010
+ + +++DA LP
Sbjct: 739 FITDMFDAWDAFVDLP 754
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 144 bits (362), Expect = 6e-34
Identities = 104/376 (27%), Positives = 167/376 (44%), Gaps = 64/376 (17%)
Query: 651 TNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLL 710
+NI +SLD + +E W+F IFEL + L M+ F G+
Sbjct: 473 SNIITPISLDDV-PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARF---GIC 528
Query: 711 EIFKIPTQQFMNYFRALENGYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGT 769
E ++ + +E Y PYHN H+ DVLHA
Sbjct: 529 EFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHAT-------------------- 568
Query: 770 GNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRT 829
AY SK + + ++ +A +AA +HD DHPGRT
Sbjct: 569 ---------------AYFLSKER---------IKETLDPIDEVAALIAATIHDVDHPGRT 604
Query: 830 NAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEA 889
N+FL + A+LYND +VLE+HHAA A+ L + N +++ +++ R +I+
Sbjct: 605 NSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDM 664
Query: 890 ILATDLKKHFD----FLAEFNAKANDVNSNGIEWSNE----------NDRLLVCQVCIKL 935
+LAT++ KHF+ F+ N + NG N+ +R L+ ++ IK
Sbjct: 665 VLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKC 724
Query: 936 ADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLP-ISPFMDRSSPQLAKLQESFITH 994
AD++ P + ++W I E++ Q DEE GLP + P DR++ + K Q SFI +
Sbjct: 725 ADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDY 784
Query: 995 IVGPLCNSYDAAGLLP 1010
+ + +++DA LP
Sbjct: 785 FITDMFDAWDAFVDLP 800
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 140 bits (353), Expect = 7e-33
Identities = 108/402 (26%), Positives = 175/402 (43%), Gaps = 72/402 (17%)
Query: 662 ILVEEYDS----LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPT 717
IL ++Y+ ++EK+ NWNF IF L +++ +G L + + LF GL+E F +
Sbjct: 109 ILDDDYNGQAKCMLEKVGNWNFDIF-LFDRL--TNGNSLVSLTFHLFSLHGLIEYFHLDM 165
Query: 718 QQFMNYFRALENGYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSD 776
+ + ++ Y PYHN +HA DV A+ P
Sbjct: 166 MKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPK------------------- 206
Query: 777 GRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVAT 836
L++++ +++ +AAA HD DHPG FL+ T
Sbjct: 207 -------------------------LANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
Query: 837 NAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLK 896
N A LY + SVLENHH SA L E HL ++ + ILATD+
Sbjct: 242 NHYLATLYKNTSVLENHHWRSAVGLLR---ESGLFSHLPLESRQQMETQIGALILATDIS 298
Query: 897 KHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIV 956
+ ++L+ F + ++ + + R LV Q+ +K ADI P + +L +W+E +
Sbjct: 299 RQNEYLSLFRSH---LDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVT 355
Query: 957 NEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY------------- 1003
EF+ QGD E L +SP DR + +A +Q F+T++V PL +
Sbjct: 356 EEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTML 415
Query: 1004 DAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLN 1045
GL W + + + S D + EL+++ EN L+
Sbjct: 416 GHVGLNKASWKGLQRE-QSSSEDTDAAFELNSQLLPQENRLS 456
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 130 bits (326), Expect = 9e-30
Identities = 94/339 (27%), Positives = 151/339 (44%), Gaps = 58/339 (17%)
Query: 662 ILVEEYDS----LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPT 717
IL ++Y+ ++EK+ NWNF IF L +++ +G L + + LF GL+E F +
Sbjct: 135 ILDDDYNGQAKCMLEKVGNWNFDIF-LFDRL--TNGNSLVSLTFHLFSLHGLIEYFHLDM 191
Query: 718 QQFMNYFRALENGYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSD 776
+ + ++ Y PYHN +HA DV A+ P
Sbjct: 192 MKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPK------------------- 232
Query: 777 GRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVAT 836
L++++ +++ +AAA HD DHPG FL+ T
Sbjct: 233 -------------------------LANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
Query: 837 NAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLK 896
N A LY + SVLENHH SA L E HL ++ + ILATD+
Sbjct: 268 NHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDIS 324
Query: 897 KHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIV 956
+ ++L+ F + ++ + + R LV Q+ +K ADI P + +L +W+E +
Sbjct: 325 RQNEYLSLFR---SHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVT 381
Query: 957 NEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHI 995
EF+ QGD E L +SP DR + +A +Q T++
Sbjct: 382 EEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 128 bits (321), Expect = 3e-29
Identities = 105/394 (26%), Positives = 163/394 (41%), Gaps = 73/394 (18%)
Query: 670 LIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALEN 729
++ K+ W+F IF L +++ +G L ++ LF GL+ FK+ + ++
Sbjct: 108 MLSKVGMWDFDIF-LFDRL--TNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQE 164
Query: 730 GYRDI-PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Y PYHN +HA DV A+ P
Sbjct: 165 DYHSQNPYHNAVHAADVTQAMHCYLKEPK------------------------------- 193
Query: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
L+S + L++M +AAA HD DHPG FL+ TN A LY + S
Sbjct: 194 -------------LASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS 240
Query: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
VLENHH S + E L HL + + ILATD+ + +FL A
Sbjct: 241 VLENHHWRSTIGMLR---ESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAH 297
Query: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
+++ + + DR + Q+ +K ADI P ++ ++ +W+E + EFY QG+ E
Sbjct: 298 ---LHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQK 354
Query: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGPLC--------NSYDAAGLL------PGQW- 1013
L ISP ++ + +Q F+++IV PL NS + +L QW
Sbjct: 355 FELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWK 414
Query: 1014 ----LEAEEDNDTESGDDEDGEELDTEDEEMENN 1043
+ + SG D D TE EE E +
Sbjct: 415 SLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGD 448
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 120 bits (302), Expect = 5e-27
Identities = 81/297 (27%), Positives = 127/297 (42%), Gaps = 50/297 (16%)
Query: 703 LFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQ 762
++ D GL+ F I + + + YR+ P+HN H V
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV----------------- 113
Query: 763 IHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHD 822
++ Y CS L +++ L AA HD
Sbjct: 114 -------------------AQMMYSMVWLCS--------LQEKFSQTDILILMTAAICHD 146
Query: 823 YDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRF 882
DHPG N + + AV YND S LENHH A A+ + L+ PE N ++ FK+
Sbjct: 147 LDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAEPECNIFSNIPPDGFKQI 205
Query: 883 RFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPA 942
R +I ILATD+ +H + + F K + ++SNE L+ + IK DI+
Sbjct: 206 RQGMITLILATDMARHAEIMDSFKEKMEN-----FDYSNEEHMTLLKMILIKCCDISNEV 260
Query: 943 KVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPL 999
+ ++ W + ++ E++ Q D E + GLP++PFMDR A Q FI ++ P+
Sbjct: 261 RPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPM 317
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,656,283
Number of Sequences: 37866
Number of extensions: 2576774
Number of successful extensions: 12718
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 10984
Number of HSP's gapped (non-prelim): 1400
length of query: 1112
length of database: 18,247,518
effective HSP length: 113
effective length of query: 999
effective length of database: 13,968,660
effective search space: 13954691340
effective search space used: 13954691340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.