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Search of human proteins with 39812229
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39812229 karyopherin alpha 5 [Homo sapiens]
(539 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39812229 karyopherin alpha 5 [Homo sapiens] 1077 0.0
gi|6912478 karyopherin alpha 6 [Homo sapiens] 909 0.0
gi|222144293 karyopherin alpha 1 [Homo sapiens] 865 0.0
gi|4504901 karyopherin alpha 4 [Homo sapiens] 476 e-134
gi|34485722 karyopherin alpha 3 [Homo sapiens] 474 e-133
gi|4504897 karyopherin alpha 2 [Homo sapiens] 458 e-129
gi|224589129 karyopherin 7 [Homo sapiens] 372 e-103
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 83 7e-16
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 83 7e-16
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 59 1e-08
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 59 1e-08
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 59 1e-08
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 57 4e-08
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 49 1e-05
gi|211059433 coiled-coil domain containing 79 [Homo sapiens] 47 6e-05
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 47 6e-05
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 46 8e-05
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 46 8e-05
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 46 8e-05
gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens] 44 5e-04
gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens] 44 5e-04
gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens] 44 5e-04
gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6 [... 42 0.001
gi|19923142 karyopherin beta 1 [Homo sapiens] 40 0.007
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD... 39 0.009
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD... 39 0.009
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ... 39 0.009
gi|53829376 plakophilin 4 isoform b [Homo sapiens] 39 0.012
gi|53829374 plakophilin 4 isoform a [Homo sapiens] 39 0.012
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur... 39 0.012
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 1077 bits (2786), Expect = 0.0
Identities = 539/539 (100%), Positives = 539/539 (100%)
Query: 1 MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDE 60
MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDE
Sbjct: 1 MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDE 60
Query: 61 SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID 120
SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID
Sbjct: 61 SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID 120
Query: 121 QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN 180
QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN
Sbjct: 121 QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN 180
Query: 181 SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL 240
SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL
Sbjct: 181 SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL 240
Query: 241 CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR 300
CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR
Sbjct: 241 CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR 300
Query: 301 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 360
RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC
Sbjct: 301 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 360
Query: 361 WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 420
WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL
Sbjct: 361 WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 420
Query: 421 VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD 480
VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD
Sbjct: 421 VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD 480
Query: 481 KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL 539
KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL
Sbjct: 481 KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL 539
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 909 bits (2348), Expect = 0.0
Identities = 453/539 (84%), Positives = 489/539 (90%), Gaps = 3/539 (0%)
Query: 1 MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDE 60
M+ MASPGKDNYRMKSYKN ALNP+EMRRRREEEGIQLRKQKRE+QLFKRRNV L +
Sbjct: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
Query: 61 SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID 120
+M +S + D +SST E V+T +MV+M+FS+++D QL TQKFRKLLSKEP+PPID
Sbjct: 61 AMFDSLLMDSYVSSTTG---ESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPID 117
Query: 121 QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN 180
+VI P VV RFV+FL+RNENCTLQFEAAWALTNIASGT TK+VIE GAVPIFI+LLN
Sbjct: 118 EVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLN 177
Query: 181 SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL 240
S+ EDVQEQAVWALGNIAGD++ CRD+VLNC IL PLL LLT S RLT TRNAVWALSNL
Sbjct: 178 SDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNL 237
Query: 241 CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR 300
CRGKNPPP F+KVSPCL VLSRLLFSSD D+LAD CWALSYLSDGPN+KIQAVIDSGVCR
Sbjct: 238 CRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCR 297
Query: 301 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 360
RLVELLMHNDYKV SPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC
Sbjct: 298 RLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 357
Query: 361 WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 420
WT+SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL
Sbjct: 358 WTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 417
Query: 421 VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD 480
V+LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQE K++G G+NPYC LIEEAYGLD
Sbjct: 418 VSLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLD 477
Query: 481 KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL 539
KIEFLQSHENQEIYQKAFDLIEHYFGVE+DD S+ PQVDE QQQFIFQQ EAPM+GFQL
Sbjct: 478 KIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL 536
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 865 bits (2234), Expect = 0.0
Identities = 432/539 (80%), Positives = 476/539 (88%), Gaps = 4/539 (0%)
Query: 4 MASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRND---E 60
M +PGK+N+R+KSYKNK+LNP EMRRRREEEG+QLRKQKREEQLFKRRNV + E
Sbjct: 1 MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
Query: 61 SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID 120
M + + IS+ P V+T+DM++MIFS + +QQL+ATQKFRKLLSKEPNPPID
Sbjct: 61 VMSDGGFHEAQISNMEMAPGG-VITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPID 119
Query: 121 QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN 180
+VI PGVV RFV+FL+R ENCTLQFE+AW LTNIASG L T++VI+ GAVPIFI+LL+
Sbjct: 120 EVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLS 179
Query: 181 SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL 240
SE EDVQEQAVWALGNIAGD+ CRD+VL+C ILPPLL+L + NRLT TRNAVWALSNL
Sbjct: 180 SEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNL 239
Query: 241 CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR 300
CRGK+PPP F+KVSPCLNVLS LLF SD DVLAD CWALSYLSDGPNDKIQAVID+GVCR
Sbjct: 240 CRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCR 299
Query: 301 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 360
RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSAL LLHLLSSPKESI+KEAC
Sbjct: 300 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEAC 359
Query: 361 WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 420
WT+SNITAGNRAQIQ VIDANIFP LI ILQ AEFRTRKEAAWAITNATSGG+ EQI+YL
Sbjct: 360 WTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYL 419
Query: 421 VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD 480
V LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQE+K+NG GINPYCALIEEAYGLD
Sbjct: 420 VELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLD 479
Query: 481 KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL 539
KIEFLQSHENQEIYQKAFDLIEHYFG E++D SI PQVD NQQQ+IFQQ EAPM+GFQL
Sbjct: 480 KIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL 538
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 476 bits (1226), Expect = e-134
Identities = 255/531 (48%), Positives = 350/531 (65%), Gaps = 20/531 (3%)
Query: 10 DNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQD 69
DN R+K++KNK + + MRR+R E ++LRK KR+E L KRRNV P D +D
Sbjct: 8 DNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNV--PHEDIC------ED 59
Query: 70 PDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVV 129
DI + + +VQ S+N QL+A Q RKLLS + NPPID +I K G++
Sbjct: 60 SDIDGDYRVQNTSLEA--IVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLI-KSGIL 116
Query: 130 QRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQ 189
V LER++N +LQFEAAWALTNIASGT T+ V+++ AVP+F++LL+S H++V EQ
Sbjct: 117 PILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQ 176
Query: 190 AVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPN 249
AVWALGNI GD +CRD+V++ ++ PLL ++ S +T RN W + NLCR K+PPP
Sbjct: 177 AVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPP 236
Query: 250 FSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHN 309
+ L L L+ +D ++L D WALSYL+D N++IQ VIDSG+ LV LL H
Sbjct: 237 METIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQ 296
Query: 310 DYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAG 369
+ KV + ALRAVGNIVTG D QTQV+LNC AL LL+ PKE I KEA W +SNITAG
Sbjct: 297 EVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAG 356
Query: 370 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPL 429
N+ Q+QAVIDAN+ P++I +L K +F T+KEAAWAI+N T G +Q+ YL+ I P
Sbjct: 357 NQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPF 416
Query: 430 CDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHE 489
C+LLTV D+++VQV L+GL NIL++ E E++ G LIEE GL+KIE LQ+HE
Sbjct: 417 CNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIG-------NLIEECGGLEKIEQLQNHE 469
Query: 490 NQEIYQKAFDLIEHYFGVE--EDDPSIVPQVDENQQQFIFQQQEAPMDGFQ 538
N++IY+ A+++I+ +F + ++DPS+VP+ + P +GFQ
Sbjct: 470 NEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQ 520
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 474 bits (1219), Expect = e-133
Identities = 252/517 (48%), Positives = 343/517 (66%), Gaps = 20/517 (3%)
Query: 6 SPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLES 65
+P +N+R+KS+KNK + + MRR R E ++LRK KR+E L K+RNV E LE
Sbjct: 4 NPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNV----PQEESLED 59
Query: 66 PIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQK 125
D D + + V ++Q S+N QL+A Q RKLLS + NPPID +I K
Sbjct: 60 SDVDADFKA------QNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLI-K 112
Query: 126 PGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHED 185
G++ VK LER++N +LQFEAAWALTNIASGT T+ V+++ AVP+F++LL S H++
Sbjct: 113 SGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQN 172
Query: 186 VQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKN 245
V EQAVWALGNI GD +CRD+V++ ++ PLL ++ S +T RN W + NLCR K+
Sbjct: 173 VCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKD 232
Query: 246 PPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVEL 305
PPP V L L L++ +D ++L D WALSYL+DG N++IQ VIDSGV LV L
Sbjct: 233 PPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPL 292
Query: 306 LMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSN 365
L H + KV + ALRAVGNIVTG D QTQV+LNC L +LLS PKE I KEA W +SN
Sbjct: 293 LSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSN 352
Query: 366 ITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGC 425
ITAGN+ Q+QAVIDA + P++I L K +F T+KEAAWAI+N T G +Q+ YLV
Sbjct: 353 ITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNV 412
Query: 426 IKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFL 485
I P C+LL+V DS++VQV L+GL+NIL + E+ + +IEE GL+KIE L
Sbjct: 413 IPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEA-------STIAEIIEECGGLEKIEVL 465
Query: 486 QSHENQEIYQKAFDLIEHYFGVE--EDDPSIVPQVDE 520
Q HEN++IY+ AF++I+ YF + ++DP ++P+ +
Sbjct: 466 QQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQ 502
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 458 bits (1179), Expect = e-129
Identities = 254/525 (48%), Positives = 345/525 (65%), Gaps = 22/525 (4%)
Query: 13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDP-D 71
R+ +KNK + EMRRRR E ++LRK K+++Q+ KRRNV +D + SP+Q+ +
Sbjct: 13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDAT---SPLQENRN 69
Query: 72 ISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQR 131
TV + D+V+ I S+N + QL ATQ RKLLS+E PPID +I + G++ +
Sbjct: 70 NQGTVNWSVD-----DIVKGINSSNVENQLQATQAARKLLSREKQPPIDNII-RAGLIPK 123
Query: 132 FVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAV 191
FV FL R + +QFE+AWALTNIASGT TK V++ GA+P FI LL S H + EQAV
Sbjct: 124 FVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAV 183
Query: 192 WALGNIAGDNAECRDFVLNCEILPPLLELLT----NSNRLTTTRNAVWALSNLCRGKNPP 247
WALGNIAGD + RD V+ + PLL LL +S RN W LSNLCR KNP
Sbjct: 184 WALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPA 243
Query: 248 PNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLM 307
P V L L RLL DP+VLAD CWA+SYL+DGPN++I V+ +GV +LV+LL
Sbjct: 244 PPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLG 303
Query: 308 HNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNIT 367
++ +V+PALRA+GNIVTG D QTQV+++ AL LL++PK +I+KEA WT+SNIT
Sbjct: 304 ASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT 363
Query: 368 AGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIK 427
AG + QIQ V++ + P L+ +L KA+F+T+KEA WA+TN TSGGT EQI YLV G I+
Sbjct: 364 AGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIE 423
Query: 428 PLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQS 487
PL +LLT D+KI+ V L+ + NI + E+ + + I +IEE GLDKIE LQ+
Sbjct: 424 PLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSI-----MIEECGGLDKIEALQN 478
Query: 488 HENQEIYQKAFDLIEHYFGV-EEDDPSIVPQVDENQQQFIFQQQE 531
HEN+ +Y+ + LIE YF V EE+D ++VP+ + + FQ Q+
Sbjct: 479 HENESVYKASLSLIEKYFSVEEEEDQNVVPET--TSEGYTFQVQD 521
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 372 bits (954), Expect = e-103
Identities = 214/515 (41%), Positives = 311/515 (60%), Gaps = 17/515 (3%)
Query: 13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDI 72
R + +K + + R++R ++LRK K++EQ KRRN+ S D
Sbjct: 10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNI----------TSFCPDTPS 59
Query: 73 SSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRF 132
T + ++++ + S++ ATQ RK+LS+E NPP+ VI+ G++ R
Sbjct: 60 EKTAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEA-GLIPRM 118
Query: 133 VKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVW 192
V+FL+ + LQFEAAWALTNIASGT T+ V+E GA+ I+LL+S + V EQAVW
Sbjct: 119 VEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVW 178
Query: 193 ALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSK 252
ALGNIAGD E RD V+ +P LL L++ + +T RN W LSNLCR KNP P +
Sbjct: 179 ALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTA 238
Query: 253 VSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYK 312
V L L LL D +VL+D CWALSYL+DG N +I V+++GV RLV L+ ++
Sbjct: 239 VKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELN 298
Query: 313 VVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRA 372
V++P+LR VGNIVTG D QTQ+ ++ L L LL K SI+KEA W +SN+ AG
Sbjct: 299 VLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCH 358
Query: 373 QIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDL 432
IQ ++ ++ P L+ +L+ EF+ +KEA W + N +G T +Q+ LV G ++PL +L
Sbjct: 359 HIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNL 418
Query: 433 LTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQE 492
LT D KIV + L+ + IL+ E+ S++ + C LIEE G+D+IE LQ HEN++
Sbjct: 419 LTAPDVKIVLIILDVISCILQAAEKRSEKENL-----CLLIEELGGIDRIEALQLHENRQ 473
Query: 493 IYQKAFDLIEHYFGVEEDD-PSIVPQVDENQQQFI 526
I Q A ++IE +FG EED+ +++ QV + +FI
Sbjct: 474 IGQSALNIIEKHFGEEEDESQTLLSQVIDQDYEFI 508
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 82.8 bits (203), Expect = 7e-16
Identities = 66/266 (24%), Positives = 120/266 (45%), Gaps = 6/266 (2%)
Query: 170 GAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTT 229
G + + LL +Q+ A ALG +A N + + V+ C+ILP L+ L NR
Sbjct: 41 GVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYK 100
Query: 230 TRNAVWALSNLCRGKNPPPNFSKVSPC--LNVLSRLLFSSDPDVLADVCWALSYLSDGPN 287
+ A + L + GK+ P + C L+ L L DP V WAL Y++
Sbjct: 101 -KAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNA 157
Query: 288 DKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHL 347
+ QAV+D+G LV + + + A A+ +I Q +++ A+ L +
Sbjct: 158 ELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQM 217
Query: 348 LSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 407
+ +P ++ + +S ++ + + V++A IFPV++ L+ + +K A+ I
Sbjct: 218 ILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIRE 277
Query: 408 ATSGGTPEQIRYLVALGCIKPLCDLL 433
TPE + +V G + + D +
Sbjct: 278 IAK-HTPELSQLVVNAGGVAAVIDCI 302
Score = 64.3 bits (155), Expect = 3e-10
Identities = 74/341 (21%), Positives = 144/341 (42%), Gaps = 6/341 (1%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + + + K ++ + V L +N + AA+ L + + + +++ GA+
Sbjct: 72 NDDLAEAVVKCDILPQLVYSLAE-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235
+ L V+E A WAL IA NAE V++ +P LL L + R A
Sbjct: 131 VICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVLCIQEPEIALKRIAAS 189
Query: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVID 295
ALS++ + + + L++++ + D + + ALS +S D + V++
Sbjct: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
Query: 296 SGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESI 355
+ + ++ L D V A + I +Q+++N + ++ + S K +
Sbjct: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
Query: 356 RKEACWTVSNITAGNRAQIQAVIDANIFPVLIEIL-QKAEFRTRKEAAWAITNATSGGTP 414
R + + A + AVI + P L L ++ E + AAWA+ TP
Sbjct: 310 RLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL-GQIGRHTP 368
Query: 415 EQIRYLVALGCIKPLCDL-LTVMDSKIVQV-ALNGLENILR 453
E R + + L L ++ S+ +QV + ++NIL+
Sbjct: 369 EHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQ 409
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/204 (20%), Positives = 82/204 (40%), Gaps = 43/204 (21%)
Query: 290 IQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLS 349
I+ + ++GV L LL+ + A A+G + +D + ++ C LP L++ L+
Sbjct: 34 IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
Query: 350 --------------------SPK----------------------ESIRKEACWTVSNIT 367
SP+ +++ A W + I
Sbjct: 94 EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIA 153
Query: 368 AGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIK 427
N QAV+DA P+L+ +Q+ E ++ AA A+++ +PE + +V G +
Sbjct: 154 RHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVA 212
Query: 428 PLCDLLTVMDSKIVQVALNGLENI 451
L ++ D+K+ L+ L +
Sbjct: 213 HLAQMILNPDAKLKHQILSALSQV 236
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 82.8 bits (203), Expect = 7e-16
Identities = 66/266 (24%), Positives = 120/266 (45%), Gaps = 6/266 (2%)
Query: 170 GAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTT 229
G + + LL +Q+ A ALG +A N + + V+ C+ILP L+ L NR
Sbjct: 41 GVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYK 100
Query: 230 TRNAVWALSNLCRGKNPPPNFSKVSPC--LNVLSRLLFSSDPDVLADVCWALSYLSDGPN 287
+ A + L + GK+ P + C L+ L L DP V WAL Y++
Sbjct: 101 -KAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNA 157
Query: 288 DKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHL 347
+ QAV+D+G LV + + + A A+ +I Q +++ A+ L +
Sbjct: 158 ELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQM 217
Query: 348 LSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 407
+ +P ++ + +S ++ + + V++A IFPV++ L+ + +K A+ I
Sbjct: 218 ILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIRE 277
Query: 408 ATSGGTPEQIRYLVALGCIKPLCDLL 433
TPE + +V G + + D +
Sbjct: 278 IAK-HTPELSQLVVNAGGVAAVIDCI 302
Score = 64.3 bits (155), Expect = 3e-10
Identities = 74/341 (21%), Positives = 144/341 (42%), Gaps = 6/341 (1%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + + + K ++ + V L +N + AA+ L + + + +++ GA+
Sbjct: 72 NDDLAEAVVKCDILPQLVYSLAE-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235
+ L V+E A WAL IA NAE V++ +P LL L + R A
Sbjct: 131 VICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVLCIQEPEIALKRIAAS 189
Query: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVID 295
ALS++ + + + L++++ + D + + ALS +S D + V++
Sbjct: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
Query: 296 SGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESI 355
+ + ++ L D V A + I +Q+++N + ++ + S K +
Sbjct: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
Query: 356 RKEACWTVSNITAGNRAQIQAVIDANIFPVLIEIL-QKAEFRTRKEAAWAITNATSGGTP 414
R + + A + AVI + P L L ++ E + AAWA+ TP
Sbjct: 310 RLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL-GQIGRHTP 368
Query: 415 EQIRYLVALGCIKPLCDL-LTVMDSKIVQV-ALNGLENILR 453
E R + + L L ++ S+ +QV + ++NIL+
Sbjct: 369 EHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQ 409
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/204 (20%), Positives = 82/204 (40%), Gaps = 43/204 (21%)
Query: 290 IQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLS 349
I+ + ++GV L LL+ + A A+G + +D + ++ C LP L++ L+
Sbjct: 34 IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
Query: 350 --------------------SPK----------------------ESIRKEACWTVSNIT 367
SP+ +++ A W + I
Sbjct: 94 EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIA 153
Query: 368 AGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIK 427
N QAV+DA P+L+ +Q+ E ++ AA A+++ +PE + +V G +
Sbjct: 154 RHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVA 212
Query: 428 PLCDLLTVMDSKIVQVALNGLENI 451
L ++ D+K+ L+ L +
Sbjct: 213 HLAQMILNPDAKLKHQILSALSQV 236
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 58.9 bits (141), Expect = 1e-08
Identities = 61/290 (21%), Positives = 125/290 (43%), Gaps = 21/290 (7%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + IQ G++Q F L +C + + A + +A F+ V + G +
Sbjct: 38 NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 94
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELL-TNSNRLTTTRNAV 234
++LLNS+ ++V Q ALGNI D+ + ++N ++P L++LL + T +
Sbjct: 95 VQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCL 154
Query: 235 WALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVI 294
A NL ++ F+ + ++ + D + L+ L++ K+Q ++
Sbjct: 155 VAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQ-LV 213
Query: 295 DSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCL---------- 344
++G+ L+E++ KV S + + TG D+ ++L ++ L
Sbjct: 214 EAGLVECLLEIVQQ---KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQ 270
Query: 345 --LHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392
L + S ++ ++N A N A ++D I L+++L +
Sbjct: 271 RVLSWIPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLLDR 319
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 58.9 bits (141), Expect = 1e-08
Identities = 61/290 (21%), Positives = 125/290 (43%), Gaps = 21/290 (7%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + IQ G++Q F L +C + + A + +A F+ V + G +
Sbjct: 39 NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 95
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELL-TNSNRLTTTRNAV 234
++LLNS+ ++V Q ALGNI D+ + ++N ++P L++LL + T +
Sbjct: 96 VQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCL 155
Query: 235 WALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVI 294
A NL ++ F+ + ++ + D + L+ L++ K+Q ++
Sbjct: 156 VAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQ-LV 214
Query: 295 DSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCL---------- 344
++G+ L+E++ KV S + + TG D+ ++L ++ L
Sbjct: 215 EAGLVECLLEIVQQ---KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQ 271
Query: 345 --LHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392
L + S ++ ++N A N A ++D I L+++L +
Sbjct: 272 RVLSWIPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLLDR 320
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 58.9 bits (141), Expect = 1e-08
Identities = 106/442 (23%), Positives = 169/442 (38%), Gaps = 57/442 (12%)
Query: 25 QEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVV 84
+E+RRRR E LRK +RE+QL +R L RND ++ I E V
Sbjct: 17 EELRRRRREREAALRKARREQQLVSKR---LLRNDAP------EEAGEGCVAAILGETEV 67
Query: 85 TTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQV-IQKPGVVQRFVKFLERNENCT 143
+ Q ++ A R+ L +P Q I+ G ++ V L N+
Sbjct: 68 QQFLRQAQRGTEEKEREGALVSLRRGLQ---HPETQQTFIRLEGSMRTLVGLLTSNQ-AL 123
Query: 144 LQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAE 203
LQ EAA L + S + T A + L+S D E ++ LGN+ ++
Sbjct: 124 LQLEAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEA 182
Query: 204 CRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCL--NVLS 261
R +L I+P L + S + +ALS L + + P K+ P + + L
Sbjct: 183 VRRQLLPQGIVPALAACI-QSPHVAVLEALGYALSQLLQAEEAP---EKIIPSILASTLP 238
Query: 262 RLLFSS-------DPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVV 314
+ + +P V + W L Y +I S V L L+ H +
Sbjct: 239 QHMLQMLQPGPKLNPGVAVEFAWCLHY-----------IICSQVSNPL--LIGHGALSTL 285
Query: 315 SPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQI 374
L + V + +L C L CL +LL+ T G + Q+
Sbjct: 286 GLLLLDLAGAVQKTEDAGLELLACPVLRCLSNLLTEAAVE------------TVGGQMQL 333
Query: 375 QAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLT 434
+ +L++ + + E W + N T+ +P L++L I+PL LL
Sbjct: 334 RDERVVAALFILLQFFFQKQPSLLPEGLWLLNNLTA-NSPSFCTSLLSLDLIEPLLQLLP 392
Query: 435 VMDSKIVQV-ALNGLENILRLG 455
V S +V V L L N+ G
Sbjct: 393 V--SNVVSVMVLTVLCNVAEKG 412
Score = 32.7 bits (73), Expect = 0.86
Identities = 25/105 (23%), Positives = 48/105 (45%), Gaps = 8/105 (7%)
Query: 171 AVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTT 230
A+ I ++ + + + +W L N+ ++ +L+ +++ PLL+LL SN +
Sbjct: 341 ALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVV--- 397
Query: 231 RNAVWALSNLCRGKNPPPNFSK---VSPCLNVLSRLLFSSDPDVL 272
+V L+ LC P + + P L L L SD +V+
Sbjct: 398 --SVMVLTVLCNVAEKGPAYCQRLWPGPLLPALLHTLAFSDTEVV 440
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 57.0 bits (136), Expect = 4e-08
Identities = 84/374 (22%), Positives = 147/374 (39%), Gaps = 47/374 (12%)
Query: 79 PEEEVVTTDMVQMIFSNNADQQLTATQKFR--------KLLSKEPNPPIDQVIQKPGVVQ 130
PEEEVV + + +N + + + Q F +LLS P+P + +
Sbjct: 119 PEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLS-SPDPDVKK--------- 168
Query: 131 RFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQA 190
+E N F+ L E A+P + LL SE+ +Q A
Sbjct: 169 ---NSMECIYNLVQDFQCRAKLQ--------------ELNAIPPILDLLKSEYPVIQLLA 211
Query: 191 VWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNF 250
+ LG IA D E R + + + L L+++L A+ ++N +
Sbjct: 212 LKTLGVIANDK-ESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQI 270
Query: 251 SKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHND 310
+ +LS S+ PD+ + A++ + P ++ + + V + LV LL +
Sbjct: 271 QQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENR-KLFHEQEVEKCLVALLGSEN 329
Query: 311 YKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGN 370
A +A+ + ++ ++ N +P L+ LL S E +R+ A ++N+T N
Sbjct: 330 DGTKIAASQAISAMC--ENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCN 387
Query: 371 RAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIR-----YLVALGC 425
A A +A+ LI +L AA +TN E +R + +
Sbjct: 388 PANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNM---AMQEPLRLNIQNHDIMHAI 444
Query: 426 IKPLCDLLTVMDSK 439
I PL TV+ SK
Sbjct: 445 ISPLRSANTVVQSK 458
Score = 52.8 bits (125), Expect = 8e-07
Identities = 64/268 (23%), Positives = 117/268 (43%), Gaps = 9/268 (3%)
Query: 123 IQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSE 182
IQ+ G +++ + F E + +Q AA A+T A + K+ E + LL SE
Sbjct: 270 IQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPE-NRKLFHEQEVEKCLVALLGSE 328
Query: 183 HEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCR 242
++ + A A+ + +N+ +DF N + +P L++LL + N A AL+NL
Sbjct: 329 NDGTKIAASQAISAMC-ENSGSKDF-FNNQGIPQLIQLLKSDNE-EVREAAALALANLTT 385
Query: 243 GKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRL 302
N + + ++ L LL S +A+ L+ ++ ++ + + + +
Sbjct: 386 CNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAI 444
Query: 303 VELLMHNDYKVVSPALRAVGNIVTGDDIQTQVIL-NCSALPCLLHLLSSPKESIRKEACW 361
+ L + V S A AV T D++ + L N L L+ LL S + +RK A W
Sbjct: 445 ISPLRSANTVVQSKAALAV--TATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASW 502
Query: 362 TVSNITAGNRAQIQAVIDANIFPVLIEI 389
V + AG+ + +L E+
Sbjct: 503 AVM-VCAGDELTANELCRLGALDILEEV 529
Score = 43.9 bits (102), Expect = 4e-04
Identities = 64/279 (22%), Positives = 111/279 (39%), Gaps = 10/279 (3%)
Query: 129 VQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIE-TGAVPIFIKLL-NSEHEDV 186
+ +K LE E L EA + N + T V I+ TG + + NS D+
Sbjct: 234 LDHLIKILETKELNDLHIEALAVIANCLED--MDTMVQIQQTGGLKKLLSFAENSTIPDI 291
Query: 187 QEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNP 246
Q+ A A+ A D E R E+ L+ LL + N T A A+S +C
Sbjct: 292 QKNAAKAITKAAYD-PENRKLFHEQEVEKCLVALLGSENDGTKIA-ASQAISAMCENSGS 349
Query: 247 PPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELL 306
F+ + L +LL S + +V AL+ L+ A ++ L+ LL
Sbjct: 350 KDFFNNQG--IPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLL 407
Query: 307 MHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNI 366
++ A + N+ + ++ I N + ++ L S ++ +A V+
Sbjct: 408 SSKRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAIISPLRSANTVVQSKAALAVTAT 466
Query: 367 TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAI 405
A+ + + P L+E+L+ RK A+WA+
Sbjct: 467 ACDVEARTELRNSGGLEP-LVELLRSKNDEVRKHASWAV 504
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/236 (22%), Positives = 104/236 (44%), Gaps = 6/236 (2%)
Query: 109 KLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIE 168
K ++K P ++ + V++ + L +EN + A+ A++ + + +K
Sbjct: 297 KAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS--GSKDFFN 354
Query: 169 TGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLT 228
+P I+LL S++E+V+E A AL N+ N + + + PL+ LL +S R
Sbjct: 355 NQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLL-SSKRDG 413
Query: 229 TTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPND 288
NA L+N+ + N ++ + L S++ V + A++ +
Sbjct: 414 AIANAATVLTNMAMQEPLRLNIQN-HDIMHAIISPLRSANTVVQSKAALAVTATACDVEA 472
Query: 289 KIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCL 344
+ + + +SG LVELL + +V A AV + GD++ + AL L
Sbjct: 473 RTE-LRNSGGLEPLVELLRSKNDEVRKHASWAV-MVCAGDELTANELCRLGALDIL 526
Score = 38.5 bits (88), Expect = 0.016
Identities = 54/242 (22%), Positives = 107/242 (44%), Gaps = 20/242 (8%)
Query: 263 LLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVG 322
+L S + ++LA C A+ + + +++ G L +LL H D V A G
Sbjct: 33 MLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFG 92
Query: 323 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKE-ACWTVSNITAGNRAQIQAVIDAN 381
+ + +D++ +++ + ++ L+ +E + E A ++N++A +++Q
Sbjct: 93 ILASNNDVK-KLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGG 151
Query: 382 IFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIR-YLVALGCIKPLCDLLTVMDSKI 440
+ P LI +L + +K + I N Q R L L I P+ DLL I
Sbjct: 152 LEP-LIRLLSSPDPDVKKNSMECIYNLVQ---DFQCRAKLQELNAIPPILDLLKSEYPVI 207
Query: 441 VQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDK-IEFLQSHENQEIYQKAFD 499
+AL L I ++ES+ ++ + GLD I+ L++ E +++ +A
Sbjct: 208 QLLALKTLGVI--ANDKESR----------TMLRDNQGLDHLIKILETKELNDLHIEALA 255
Query: 500 LI 501
+I
Sbjct: 256 VI 257
Score = 33.9 bits (76), Expect = 0.39
Identities = 72/323 (22%), Positives = 125/323 (38%), Gaps = 42/323 (13%)
Query: 105 QKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTK 164
+K +K + P D ++ + V L E L +A A+ A +
Sbjct: 3 KKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILA-KACEAIYKFALKGEENKT 61
Query: 165 VVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNS 224
++E GAV KLL E + V+ A G +A +N + + + +++ ++ L
Sbjct: 62 TLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNN-DVKKLLRELDVMNSVIAQLAPE 120
Query: 225 NRLTTTRNAVWALSNLCRGKNPPPNFSKVS----PCLNVLSRLLFSSDPDVLADVCWALS 280
+ + ++LC SKV L L RLL S DPDV
Sbjct: 121 EEV-----VIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDV--------- 166
Query: 281 YLSDGPNDKIQAVIDSGVCR-RLVEL--------LMHNDYKVVS-PALRAVGNIVTGDDI 330
+ I ++ CR +L EL L+ ++Y V+ AL+ +G ++ D
Sbjct: 167 --KKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLG-VIANDKE 223
Query: 331 QTQVILNCSALPCLLHLLSSPK-ESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEI 389
++ + L L+ +L + + + EA ++N +Q L ++
Sbjct: 224 SRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGG----LKKL 279
Query: 390 LQKAEFRT----RKEAAWAITNA 408
L AE T +K AA AIT A
Sbjct: 280 LSFAENSTIPDIQKNAAKAITKA 302
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 48.9 bits (115), Expect = 1e-05
Identities = 52/191 (27%), Positives = 79/191 (41%), Gaps = 10/191 (5%)
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSN---RLTTTRN 232
+K LNSE+E +QE A+ A D E RD V L PL LL N++ RL
Sbjct: 679 VKNLNSENEQLQEHCAMAIYQCAEDK-ETRDLVRLHGGLKPLASLLNNTDNKERLAAVTG 737
Query: 233 AVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQA 292
A+W S K F + + L LL +VL +V AL +++
Sbjct: 738 AIWKCS---ISKENVTKFREYK-AIETLVGLLTDQPEEVLVNVVGALGECCQERENRV-I 792
Query: 293 VIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPK 352
V G + LV LL+ + ++ +AVG + +I + L LL +P
Sbjct: 793 VRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPE-SMMIIDRLDGVRLLWSLLKNPH 851
Query: 353 ESIRKEACWTV 363
++ A W +
Sbjct: 852 PDVKASAAWAL 862
Score = 35.4 bits (80), Expect = 0.13
Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 292 AVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSP 351
A+ D G L+ LL ++ K +L+ + I I+ Q I++ LP ++++L SP
Sbjct: 489 AIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIR-QNIVDLGGLPIMVNILDSP 547
Query: 352 KESIRKEACWTVSNITAGNRAQ 373
+S++ A T++N+ RA+
Sbjct: 548 HKSLKCLAAETIANVAKFKRAR 569
Score = 32.7 bits (73), Expect = 0.86
Identities = 44/209 (21%), Positives = 90/209 (43%), Gaps = 17/209 (8%)
Query: 165 VVIETGAVPIFIKLLNSEHEDVQEQAVWAL----GNIAGDNAECRDFVLNCEILPPLLEL 220
++ V + LL + H DV+ A WAL N R FV E++ LL+
Sbjct: 833 IIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLK- 891
Query: 221 LTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSP--CLNVLSRLLFSSDPDVLADVCWA 278
S+ + A++N+ + + N + ++ + +LS+L +++ + + A
Sbjct: 892 ---SDNKEVLASVCAAITNIAKDQE---NLAVITDHGVVPLLSKLANTNNNKLRHHLAEA 945
Query: 279 LSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILN- 337
+S +++ A + LV L ND V +A+ + +D + ++
Sbjct: 946 ISRCCMWGRNRV-AFGEHKAVAPLVRYLKSNDTNVHRATAQALYQL--SEDADNCITMHE 1002
Query: 338 CSALPCLLHLLSSPKESIRKEACWTVSNI 366
A+ LL ++ SP + +++ A +SNI
Sbjct: 1003 NGAVKLLLDMVGSPDQDLQEAAAGCISNI 1031
>gi|211059433 coiled-coil domain containing 79 [Homo sapiens]
Length = 727
Score = 46.6 bits (109), Expect = 6e-05
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 2/92 (2%)
Query: 174 IFIKLL--NSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTR 231
+F+K L +SEH V+E A++ LG IA N C+ + E+ L L+N + + R
Sbjct: 61 MFVKNLAKSSEHSMVKEAALYTLGAIAEKNVYCQQTLCTSELFEDLTWFLSNDSNINLKR 120
Query: 232 NAVWALSNLCRGKNPPPNFSKVSPCLNVLSRL 263
+V+ + L + + C+ VLSRL
Sbjct: 121 MSVYVILVLVSNNRTGQTLVRETGCITVLSRL 152
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 46.6 bits (109), Expect = 6e-05
Identities = 56/285 (19%), Positives = 119/285 (41%), Gaps = 18/285 (6%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N I I G + V L + + ++Q + A A+ ++AS L K +E
Sbjct: 825 NKEIQDAIAMEGAIPPLVA-LFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYL 883
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECR---------DFVLNCEILPPL-LELLTNSN 225
+KLL + DV+EQ AL +AG + + F++N + P ++ +
Sbjct: 884 LKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEA 943
Query: 226 RLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDG 285
+ ++++ + +C G P + ++ ++ S + +C +++ S+
Sbjct: 944 VIALSKDSRMHQNQICEGNGIAPLVRLLR--ISTIAEGTLLSVIRAVGSICIGVAHTSNP 1001
Query: 286 PNDKIQAVIDSGVCRRLVELLM-HNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPC- 343
+ Q V+D L++LL H + ++ IV G+D+ + +
Sbjct: 1002 VSQ--QFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLACIVLGNDVLQKDLHENEGFEYA 1059
Query: 344 -LLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLI 387
+L+LL S ++ I A + ++ NR Q ++++ I + I
Sbjct: 1060 DVLYLLHSTEKDICLRAGYALTLFAFNNRFQQYLILESGIMTISI 1104
Score = 43.1 bits (100), Expect = 6e-04
Identities = 51/278 (18%), Positives = 112/278 (40%), Gaps = 19/278 (6%)
Query: 148 AAWALTNIASGTFLHTKVV------------IETGAVPIF---IKLLNSEHEDVQEQAVW 192
A W T+I +H V+ + +P++ +++L E + AV
Sbjct: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVM 651
Query: 193 ALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSK 252
+L I N + +L+ +P L+ LL S+++ V LSN+ K+ +
Sbjct: 652 SLEVICLANDQYWRCILDAGTIPALINLL-KSSKIKLQCKTVGLLSNISTHKSAVHALVE 710
Query: 253 VSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYK 312
++++ LL +P+V + L ++ N + A + L+ LL N
Sbjct: 711 AGGIPSLIN-LLVCDEPEVHSRCAVILYDIAQCENKDVIAKYNG--IPSLINLLNLNIEN 767
Query: 313 VVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRA 372
V+ + + + G++ + + LP L+ LSS + ++ + ++ + N+
Sbjct: 768 VLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKE 827
Query: 373 QIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 410
A+ P L+ + + + + + A A+ + S
Sbjct: 828 IQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESLAS 865
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 46.2 bits (108), Expect = 8e-05
Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 44/280 (15%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + IQ G++Q F L +C + + A + +A F+ V + G +
Sbjct: 38 NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 94
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235
++LLNS+ ++V Q ALGNI D+ E R V ++ + +
Sbjct: 95 VQLLNSKDQEVLLQTGRALGNICYDSHEGRSAV----------------DQAGGAQIVID 138
Query: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQA-VI 294
L +LC +P ++ +L C L S+ ND +QA +I
Sbjct: 139 HLRSLCSITDP--------------------ANEKLLTVFCGMLMNYSN-ENDSLQAQLI 177
Query: 295 DSGVCRRLVELL-MH-NDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPK 352
+ GV LV+LL +H + + L A GN+ + + Q + + L+ L
Sbjct: 178 NMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQ-FASTNIAEELVKLFKKQI 236
Query: 353 ESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392
E ++E + V A N A +++A + L+EI+Q+
Sbjct: 237 EHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ 276
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 46.2 bits (108), Expect = 8e-05
Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 44/280 (15%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + IQ G++Q F L +C + + A + +A F+ V + G +
Sbjct: 39 NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 95
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235
++LLNS+ ++V Q ALGNI D+ E R V ++ + +
Sbjct: 96 VQLLNSKDQEVLLQTGRALGNICYDSHEGRSAV----------------DQAGGAQIVID 139
Query: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQA-VI 294
L +LC +P ++ +L C L S+ ND +QA +I
Sbjct: 140 HLRSLCSITDP--------------------ANEKLLTVFCGMLMNYSN-ENDSLQAQLI 178
Query: 295 DSGVCRRLVELL-MH-NDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPK 352
+ GV LV+LL +H + + L A GN+ + + Q + + L+ L
Sbjct: 179 NMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQ-FASTNIAEELVKLFKKQI 237
Query: 353 ESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392
E ++E + V A N A +++A + L+EI+Q+
Sbjct: 238 EHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ 277
>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
[Homo sapiens]
Length = 608
Score = 46.2 bits (108), Expect = 8e-05
Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 44/280 (15%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + IQ G++Q F L +C + + A + +A F+ V + G +
Sbjct: 39 NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 95
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235
++LLNS+ ++V Q ALGNI D+ E R V ++ + +
Sbjct: 96 VQLLNSKDQEVLLQTGRALGNICYDSHEGRSAV----------------DQAGGAQIVID 139
Query: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQA-VI 294
L +LC +P ++ +L C L S+ ND +QA +I
Sbjct: 140 HLRSLCSITDP--------------------ANEKLLTVFCGMLMNYSN-ENDSLQAQLI 178
Query: 295 DSGVCRRLVELL-MH-NDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPK 352
+ GV LV+LL +H + + L A GN+ + + Q + + L+ L
Sbjct: 179 NMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQ-FASTNIAEELVKLFKKQI 237
Query: 353 ESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392
E ++E + V A N A +++A + L+EI+Q+
Sbjct: 238 EHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ 277
>gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 43.5 bits (101), Expect = 5e-04
Identities = 39/146 (26%), Positives = 67/146 (45%), Gaps = 18/146 (12%)
Query: 108 RKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVI 167
R+ + K +P D + P +Q+ + +E +E + A AL N A+ F + ++
Sbjct: 102 RRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAF-NRDIIR 160
Query: 168 ETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGD-----------NAECRDFV---LNCEI 213
+ G +PI K+LN+ V+E+A+ L N++ + N C D + LN +
Sbjct: 161 DLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSV 220
Query: 214 LPPLLELLTNSNRLTTTRNAVWALSN 239
L LLTN +T T L+N
Sbjct: 221 QLAGLRLLTN---MTVTNEYQHMLAN 243
>gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 43.5 bits (101), Expect = 5e-04
Identities = 39/146 (26%), Positives = 67/146 (45%), Gaps = 18/146 (12%)
Query: 108 RKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVI 167
R+ + K +P D + P +Q+ + +E +E + A AL N A+ F + ++
Sbjct: 102 RRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAF-NRDIIR 160
Query: 168 ETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGD-----------NAECRDFV---LNCEI 213
+ G +PI K+LN+ V+E+A+ L N++ + N C D + LN +
Sbjct: 161 DLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSV 220
Query: 214 LPPLLELLTNSNRLTTTRNAVWALSN 239
L LLTN +T T L+N
Sbjct: 221 QLAGLRLLTN---MTVTNEYQHMLAN 243
>gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 43.5 bits (101), Expect = 5e-04
Identities = 39/146 (26%), Positives = 67/146 (45%), Gaps = 18/146 (12%)
Query: 108 RKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVI 167
R+ + K +P D + P +Q+ + +E +E + A AL N A+ F + ++
Sbjct: 102 RRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAF-NRDIIR 160
Query: 168 ETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGD-----------NAECRDFV---LNCEI 213
+ G +PI K+LN+ V+E+A+ L N++ + N C D + LN +
Sbjct: 161 DLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSV 220
Query: 214 LPPLLELLTNSNRLTTTRNAVWALSN 239
L LLTN +T T L+N
Sbjct: 221 QLAGLRLLTN---MTVTNEYQHMLAN 243
>gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6
[Homo sapiens]
Length = 516
Score = 42.0 bits (97), Expect = 0.001
Identities = 28/105 (26%), Positives = 50/105 (47%), Gaps = 3/105 (2%)
Query: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
N + IQ G++Q F L +C + + A + +A F+ V + G +
Sbjct: 39 NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 95
Query: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLEL 220
++LLNS+ ++V Q ALGNI D+ ++ + I L++L
Sbjct: 96 VQLLNSKDQEVLLQTGRALGNICYDSQSSKEQFASTNIAEELVKL 140
Score = 37.0 bits (84), Expect = 0.046
Identities = 26/99 (26%), Positives = 47/99 (47%)
Query: 294 IDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKE 353
+D+G+ LV+LL D +V+ RA+GNI + + + L+ L E
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSQSSKEQFASTNIAEELVKLFKKQIE 146
Query: 354 SIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392
++E + V A N A +++A + L+EI+Q+
Sbjct: 147 HDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ 185
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 39.7 bits (91), Expect = 0.007
Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 2/105 (1%)
Query: 304 ELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTV 363
E + + D++ A+ A G I+ G + L A+P L+ L+ P +R A WTV
Sbjct: 373 EHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTV 432
Query: 364 SNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 407
I A I V A + LIE L AE R WA ++
Sbjct: 433 GRICELLPEAAINDVYLAPLLQCLIEGL-SAEPRVASNVCWAFSS 476
Score = 33.1 bits (74), Expect = 0.66
Identities = 27/99 (27%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 187 QEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRG-KN 245
++ AV A G I + L + +P L+EL+ + + + A W + +C
Sbjct: 383 RDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPS-VVVRDTAAWTVGRICELLPE 441
Query: 246 PPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSD 284
N ++P L L L S++P V ++VCWA S L++
Sbjct: 442 AAINDVYLAPLLQCLIEGL-SAEPRVASNVCWAFSSLAE 479
Score = 29.6 bits (65), Expect = 7.3
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 5/72 (6%)
Query: 171 AVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTN--SNRLT 228
A+P I+L+ V++ A W +G I E +N L PLL+ L S
Sbjct: 409 AMPTLIELMKDPSVVVRDTAAWTVGRICELLPEA---AINDVYLAPLLQCLIEGLSAEPR 465
Query: 229 TTRNAVWALSNL 240
N WA S+L
Sbjct: 466 VASNVCWAFSSL 477
>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 39.3 bits (90), Expect = 0.009
Identities = 59/291 (20%), Positives = 113/291 (38%), Gaps = 17/291 (5%)
Query: 167 IETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNR 226
+ T A+P KLLN E + V +A + ++ A + + +++ ++ + N+N
Sbjct: 148 LATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTND 207
Query: 227 LTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGP 286
+ T R L NL + K S + L ++L S VL L L
Sbjct: 208 VETARCTAGTLHNLSHHREGLLAIFK-SGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQ 266
Query: 287 NDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLH 346
AV +G +++V LL + K ++ + + G+ +IL L++
Sbjct: 267 EGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVN 326
Query: 347 LLSSPKESIRKEACWTVS------NITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKE 400
++ + ++ WT S ++ + N+ A+++A L L R +
Sbjct: 327 IM---RTYTYEKLLWTTSRVLKVLSVCSSNK---PAIVEAGGMQALGLHLTDPSQRLVQN 380
Query: 401 AAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENI 451
W + N + T ++ G + L LL D +V A L N+
Sbjct: 381 CLWTLRNLSDAATKQE----GMEGLLGTLVQLLGSDDINVVTCAAGILSNL 427
>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 39.3 bits (90), Expect = 0.009
Identities = 59/291 (20%), Positives = 113/291 (38%), Gaps = 17/291 (5%)
Query: 167 IETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNR 226
+ T A+P KLLN E + V +A + ++ A + + +++ ++ + N+N
Sbjct: 148 LATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTND 207
Query: 227 LTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGP 286
+ T R L NL + K S + L ++L S VL L L
Sbjct: 208 VETARCTAGTLHNLSHHREGLLAIFK-SGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQ 266
Query: 287 NDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLH 346
AV +G +++V LL + K ++ + + G+ +IL L++
Sbjct: 267 EGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVN 326
Query: 347 LLSSPKESIRKEACWTVS------NITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKE 400
++ + ++ WT S ++ + N+ A+++A L L R +
Sbjct: 327 IM---RTYTYEKLLWTTSRVLKVLSVCSSNK---PAIVEAGGMQALGLHLTDPSQRLVQN 380
Query: 401 AAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENI 451
W + N + T ++ G + L LL D +V A L N+
Sbjct: 381 CLWTLRNLSDAATKQE----GMEGLLGTLVQLLGSDDINVVTCAAGILSNL 427
>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 39.3 bits (90), Expect = 0.009
Identities = 59/291 (20%), Positives = 113/291 (38%), Gaps = 17/291 (5%)
Query: 167 IETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNR 226
+ T A+P KLLN E + V +A + ++ A + + +++ ++ + N+N
Sbjct: 148 LATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTND 207
Query: 227 LTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGP 286
+ T R L NL + K S + L ++L S VL L L
Sbjct: 208 VETARCTAGTLHNLSHHREGLLAIFK-SGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQ 266
Query: 287 NDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLH 346
AV +G +++V LL + K ++ + + G+ +IL L++
Sbjct: 267 EGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVN 326
Query: 347 LLSSPKESIRKEACWTVS------NITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKE 400
++ + ++ WT S ++ + N+ A+++A L L R +
Sbjct: 327 IM---RTYTYEKLLWTTSRVLKVLSVCSSNK---PAIVEAGGMQALGLHLTDPSQRLVQN 380
Query: 401 AAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENI 451
W + N + T ++ G + L LL D +V A L N+
Sbjct: 381 CLWTLRNLSDAATKQE----GMEGLLGTLVQLLGSDDINVVTCAAGILSNL 427
>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
Length = 1149
Score = 38.9 bits (89), Expect = 0.012
Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 3/137 (2%)
Query: 247 PPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELL 306
P F+ P L + +L P V A+ L +L G N V G + LV+LL
Sbjct: 520 PREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLL 579
Query: 307 MHNDYKVVSPALRAVGNIVTGDDIQTQVIL--NCSALPCLLHLL-SSPKESIRKEACWTV 363
H +V A A+ N+V G I N +P LL LL S +R+ +
Sbjct: 580 DHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVL 639
Query: 364 SNITAGNRAQIQAVIDA 380
N+++ + ++ + DA
Sbjct: 640 WNLSSCDAVKMTIIRDA 656
Score = 36.2 bits (82), Expect = 0.078
Identities = 53/231 (22%), Positives = 96/231 (41%), Gaps = 51/231 (22%)
Query: 111 LSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGT-----FLHTKV 165
LSK P +++ P VV+ ++ L + N +A +L N+++G ++ V
Sbjct: 811 LSKSPKGV--EMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAV 868
Query: 166 VIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSN 225
E G +PI ++LL +++ V AL N+A D V N E++
Sbjct: 869 RKEKG-LPILVELLRMDNDRVVSSVATALRNMALD-------VRNKELI----------- 909
Query: 226 RLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDG 285
+ A+ L N G N P +VLS + +A +C AL ++
Sbjct: 910 ----GKYAMRDLVNRLPGGNGP----------SVLS-------DETMAAICCALHEVTSK 948
Query: 286 PNDKIQAVIDSGVCRRLVELLM----HNDYKVVSPALRAVGNIVTGDDIQT 332
+ +A+ DSG +LV + + KVV A + + + D+++
Sbjct: 949 NMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRS 999
Score = 30.4 bits (67), Expect = 4.3
Identities = 19/94 (20%), Positives = 40/94 (42%), Gaps = 2/94 (2%)
Query: 302 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 361
++ +L H V + A + ++ GD+ + + L+ LL ++K AC
Sbjct: 533 VIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACG 592
Query: 362 TVSNITAGNRAQIQAVIDANI--FPVLIEILQKA 393
+ N+ G + N+ P L+ +L+K+
Sbjct: 593 ALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS 626
>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
Length = 1192
Score = 38.9 bits (89), Expect = 0.012
Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 3/137 (2%)
Query: 247 PPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELL 306
P F+ P L + +L P V A+ L +L G N V G + LV+LL
Sbjct: 520 PREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLL 579
Query: 307 MHNDYKVVSPALRAVGNIVTGDDIQTQVIL--NCSALPCLLHLL-SSPKESIRKEACWTV 363
H +V A A+ N+V G I N +P LL LL S +R+ +
Sbjct: 580 DHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVL 639
Query: 364 SNITAGNRAQIQAVIDA 380
N+++ + ++ + DA
Sbjct: 640 WNLSSCDAVKMTIIRDA 656
Score = 36.2 bits (82), Expect = 0.078
Identities = 53/231 (22%), Positives = 96/231 (41%), Gaps = 51/231 (22%)
Query: 111 LSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGT-----FLHTKV 165
LSK P +++ P VV+ ++ L + N +A +L N+++G ++ V
Sbjct: 811 LSKSPKGV--EMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAV 868
Query: 166 VIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSN 225
E G +PI ++LL +++ V AL N+A D V N E++
Sbjct: 869 RKEKG-LPILVELLRMDNDRVVSSVATALRNMALD-------VRNKELI----------- 909
Query: 226 RLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDG 285
+ A+ L N G N P +VLS + +A +C AL ++
Sbjct: 910 ----GKYAMRDLVNRLPGGNGP----------SVLS-------DETMAAICCALHEVTSK 948
Query: 286 PNDKIQAVIDSGVCRRLVELLM----HNDYKVVSPALRAVGNIVTGDDIQT 332
+ +A+ DSG +LV + + KVV A + + + D+++
Sbjct: 949 NMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRS 999
Score = 30.4 bits (67), Expect = 4.3
Identities = 19/94 (20%), Positives = 40/94 (42%), Gaps = 2/94 (2%)
Query: 302 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 361
++ +L H V + A + ++ GD+ + + L+ LL ++K AC
Sbjct: 533 VIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACG 592
Query: 362 TVSNITAGNRAQIQAVIDANI--FPVLIEILQKA 393
+ N+ G + N+ P L+ +L+K+
Sbjct: 593 ALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS 626
>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
plakophilin-related arm-repeat protein) [Homo sapiens]
Length = 1225
Score = 38.9 bits (89), Expect = 0.012
Identities = 65/262 (24%), Positives = 105/262 (40%), Gaps = 29/262 (11%)
Query: 247 PPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVID-SGVCRRLVEL 305
P F P L + ++L P V ++ L +L G N KI+A I G + LV+L
Sbjct: 542 PREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDN-KIKAEIRRQGGIQLLVDL 600
Query: 306 LMHNDYKVVSPALRAVGNIVTG--DDIQTQVILNCSALPCLLHLLSSPKESIRKE----A 359
L H +V A A+ N+V G +D + NC +P L+ LL + +E
Sbjct: 601 LDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGV 660
Query: 360 CWTVSNITAGNRAQIQAVIDANIFPVLI-------------EILQKAEFRTRKEAAWAIT 406
W +S+ A IQ + V+I +Q + + A +
Sbjct: 661 LWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLR 720
Query: 407 NATSGGTPEQIRYLVALGCIKPLCDLL------TVMDSKIVQVALNGLENI-LRLGEQES 459
N +S G + R G L ++ + +DSK V+ + L N+ RL + S
Sbjct: 721 NVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETS 780
Query: 460 KQNGIGINPYCALI-EEAYGLD 480
+ +G + L+ EA G D
Sbjct: 781 QGQHMGTDELDGLLCGEANGKD 802
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,682,973
Number of Sequences: 37866
Number of extensions: 914714
Number of successful extensions: 3709
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 3278
Number of HSP's gapped (non-prelim): 287
length of query: 539
length of database: 18,247,518
effective HSP length: 107
effective length of query: 432
effective length of database: 14,195,856
effective search space: 6132609792
effective search space used: 6132609792
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.