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Search of human proteins with 38787935
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]
(1161 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens] 2363 0.0
gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens] 1332 0.0
gi|148277037 AP2 associated kinase 1 [Homo sapiens] 667 0.0
gi|157384971 cyclin G associated kinase [Homo sapiens] 182 1e-45
gi|57165436 serine/threonine kinase 16 [Homo sapiens] 108 2e-23
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 108 2e-23
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 104 4e-22
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 96 2e-19
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 96 2e-19
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 96 2e-19
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 95 3e-19
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 95 4e-19
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 92 2e-18
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 90 1e-17
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 90 1e-17
gi|110347429 mediator complex subunit 12 [Homo sapiens] 90 1e-17
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 89 3e-17
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 89 3e-17
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 86 3e-16
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] 84 8e-16
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 84 8e-16
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 83 1e-15
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 83 2e-15
gi|17017963 forkhead box P2 isoform I [Homo sapiens] 82 2e-15
gi|226246533 TOX high mobility group box family member 3 isoform... 82 2e-15
gi|226054295 TOX high mobility group box family member 3 isoform... 82 2e-15
gi|221139761 zinc finger protein 853 [Homo sapiens] 82 3e-15
gi|22538413 forkhead box P2 isoform III [Homo sapiens] 82 3e-15
gi|149999352 forkhead box P2 isoform II [Homo sapiens] 82 3e-15
gi|33286444 mastermind-like 2 [Homo sapiens] 82 3e-15
>gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]
Length = 1161
Score = 2363 bits (6123), Expect = 0.0
Identities = 1161/1161 (100%), Positives = 1161/1161 (100%)
Query: 1 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
Sbjct: 1 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
Query: 61 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
Sbjct: 61 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
Query: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180
DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
Sbjct: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180
Query: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240
LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
Sbjct: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240
Query: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300
KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
Sbjct: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300
Query: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360
DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
Sbjct: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360
Query: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420
IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
Sbjct: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420
Query: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480
ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
Sbjct: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480
Query: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540
QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
Sbjct: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540
Query: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600
QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
Sbjct: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600
Query: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSD 660
ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSD
Sbjct: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSD 660
Query: 661 KNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD 720
KNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD
Sbjct: 661 KNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD 720
Query: 721 QRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPE 780
QRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPE
Sbjct: 721 QRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPE 780
Query: 781 NLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSA 840
NLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSA
Sbjct: 781 NLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSA 840
Query: 841 QLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTK 900
QLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTK
Sbjct: 841 QLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTK 900
Query: 901 APFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFD 960
APFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFD
Sbjct: 901 APFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFD 960
Query: 961 EITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARR 1020
EITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARR
Sbjct: 961 EITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARR 1020
Query: 1021 HKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLS 1080
HKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLS
Sbjct: 1021 HKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLS 1080
Query: 1081 WHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQ 1140
WHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQ
Sbjct: 1081 WHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQ 1140
Query: 1141 SQQSQPVELDPFGAAPFPSKQ 1161
SQQSQPVELDPFGAAPFPSKQ
Sbjct: 1141 SQQSQPVELDPFGAAPFPSKQ 1161
>gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]
Length = 662
Score = 1332 bits (3448), Expect = 0.0
Identities = 650/652 (99%), Positives = 652/652 (100%)
Query: 1 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
Sbjct: 1 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
Query: 61 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
Sbjct: 61 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
Query: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180
DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
Sbjct: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180
Query: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240
LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
Sbjct: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240
Query: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300
KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
Sbjct: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300
Query: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360
DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
Sbjct: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360
Query: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420
IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
Sbjct: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420
Query: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480
ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
Sbjct: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480
Query: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540
QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
Sbjct: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540
Query: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600
QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
Sbjct: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600
Query: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNR 652
ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRS++
Sbjct: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSSK 652
>gi|148277037 AP2 associated kinase 1 [Homo sapiens]
Length = 961
Score = 667 bits (1721), Expect = 0.0
Identities = 391/776 (50%), Positives = 474/776 (61%), Gaps = 99/776 (12%)
Query: 1 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
MKKF + +GGSG G+ G GG+ +G G G G RVF +GR QVT++E LAEG
Sbjct: 1 MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIG-----RVFGIGRQQVTVDEVLAEG 55
Query: 61 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
GF+ VFLVRT G++CALKRM+VNN DL VCKREI IM++LSGHKNIVGY+D ++N++S
Sbjct: 56 GFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVS 115
Query: 121 D-NVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHR 179
+VWEVLILM++CR GQVVN MN++LQTGFTE EVLQIFCDTCEAVARLHQCKTPIIHR
Sbjct: 116 SGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHR 175
Query: 180 DLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYG 239
DLKVENILL+D G+YVLCDFGSATNKF NPQ +GVN VE+EIKKYTTLSYRAPEM+NLY
Sbjct: 176 DLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS 235
Query: 240 GKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLE 299
GK ITTKADIWALGCLLYKLC+FTLPFGESQVAICDGNFTIPDNSRYS+++HCLIR+MLE
Sbjct: 236 GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLE 295
Query: 300 PDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITD 359
PDP+ RPDI+QVSYF+FK KK+CP+ N+ NS IP+ LPEP+ ASEAAA+K+Q KAR+TD
Sbjct: 296 PDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTD 355
Query: 360 TIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----PGEFGNHRPKGALRP 415
I TETSIAPRQRPKA T P +L IQ + TP K P G+ G L
Sbjct: 356 PIPTTETSIAPRQRPKAGQ-TQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLAS 414
Query: 416 GNGPEILLGQGPPQQP--------PQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ---QQ 464
P+ Q PP QP PQ QQ + Q HQQQ +Q
Sbjct: 415 VPQPK---PQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQ 471
Query: 465 QQQQQQQQQQQQQ------QQQQQQQQQHHHHH-------------------HHHLLQDA 499
QQQQQQ QQQ QQQQ Q QQ H L+Q+
Sbjct: 472 QQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF 531
Query: 500 YMQQYQHATQQQQM-----------------LQQQFLMHSVYQPQPSASQYPTMMPQYQQ 542
Y QQ Q QQQQ LQQ+ M + QPQP + P P +
Sbjct: 532 YQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEP 591
Query: 543 AFFQQQMLAQHQPSQQQASPEY--------LTSPQE-----------FSPALVSYTSSLP 583
A Q + QP Q P LT P S S +P
Sbjct: 592 AI---QAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVP 648
Query: 584 AQVGTIM------DSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTE 637
A T + ++S + ++S + + T+Q+N+ NP + S WNPF +DNFSKLT
Sbjct: 649 ASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTA 708
Query: 638 EELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKK 693
EELL+++F L + E+ + +SL D F + F +G+ EK+
Sbjct: 709 EELLNKDFAKLGEGKHPEKLGG--SAESLIPGFQSTQGDAFATTSF--SAGTAEKR 760
>gi|157384971 cyclin G associated kinase [Homo sapiens]
Length = 1311
Score = 182 bits (463), Expect = 1e-45
Identities = 122/301 (40%), Positives = 163/301 (54%), Gaps = 15/301 (4%)
Query: 23 AGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHG-GIRCALKRM 81
AG G G S + +G ++ + LAEGGF+ V+ + G G ALKR+
Sbjct: 12 AGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL 71
Query: 82 YVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVW-----EVLILMEYCRAG 136
N +E+ MK+LSGH NIV + C+ SI E L+L E C+ G
Sbjct: 72 LSNEEEKNRAIIQEVCFMKKLSGHPNIVQF--CSAASIGKEESDTGQAEFLLLTELCK-G 128
Query: 137 QVVNQMNKKLQTG-FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV 195
Q+V + K G + VL+IF TC AV +H+ K PIIHRDLKVEN+LL++ G
Sbjct: 129 QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIK 188
Query: 196 LCDFGSATNKFLNP----QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWA 251
LCDFGSAT P +VEEEI + TT YR PE+I+LY PI K DIWA
Sbjct: 189 LCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWA 248
Query: 252 LGCLLYKLCFFTLPFGE-SQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQ 310
LGC+LY LCF PF + +++ I +G ++IP + H LIR ML+ +PE R I +
Sbjct: 249 LGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAE 308
Query: 311 V 311
V
Sbjct: 309 V 309
>gi|57165436 serine/threonine kinase 16 [Homo sapiens]
Length = 305
Score = 108 bits (271), Expect = 2e-23
Identities = 79/264 (29%), Positives = 124/264 (46%), Gaps = 14/264 (5%)
Query: 55 ESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLD 113
+ L EGGFS V LV H G ALKR+ + D +RE M L H NI+ +
Sbjct: 24 QKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREAD-MHRLFNHPNILRLVA 82
Query: 114 CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTG--FTEPEVLQIFCDTCEAVARLHQ 171
+ E +L+ + + G + N++ + G TE ++L + C + +H
Sbjct: 83 YCLRERGAK-HEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHA 141
Query: 172 CKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNV-VEEEIKKYTTLSYR 230
HRDLK NILL D G VL D GS ++ + + +++ + T+SYR
Sbjct: 142 --KGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYR 199
Query: 231 APEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF------GESQVAICDGNFTIPDNS 284
APE+ ++ I + D+W+LGC+LY + F P+ G+S +IP +
Sbjct: 200 APELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSP 259
Query: 285 RYSRNIHCLIRFMLEPDPEHRPDI 308
R+S + L+ M+ DP RP I
Sbjct: 260 RHSSALRQLLNSMMTVDPHQRPHI 283
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 108 bits (271), Expect = 2e-23
Identities = 79/263 (30%), Positives = 130/263 (49%), Gaps = 29/263 (11%)
Query: 55 ESLAEGGFSTVFLVRTHGGIR-CALKRMYVNNMP--DLNVCKREITIMKELSGHKNIVGY 111
+++ +G F +L + + C +K + MP + K+E+ +++++ H NIV +
Sbjct: 8 KAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK-HPNIVAF 66
Query: 112 LDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQ 171
NS +N + I+MEYC G ++ ++N++ F+E ++L F + +H
Sbjct: 67 F----NSFQEN-GRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121
Query: 172 CKTPIIHRDLKVENILLNDGGNYV-LCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYR 230
K I+HRD+K +NI L+ G L DFG A + LN N +E T Y
Sbjct: 122 RK--ILHRDIKAQNIFLSKNGMVAKLGDFGIA--RVLN------NSMELARTCIGTPYYL 171
Query: 231 APEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSR 285
+PE+ KP K DIW+LGC+LY+LC PF + + IC +F P +
Sbjct: 172 SPEICQ---NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFA-PISPG 227
Query: 286 YSRNIHCLIRFMLEPDPEHRPDI 308
+SR +H LI + + P RP I
Sbjct: 228 FSRELHSLISQLFQVSPRDRPSI 250
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 104 bits (260), Expect = 4e-22
Identities = 79/262 (30%), Positives = 126/262 (48%), Gaps = 28/262 (10%)
Query: 55 ESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMP--DLNVCKREITIMKELSGHKNIVGY 111
+ + EG F LV+ T G + +K + ++ M + +RE+ ++ + H NIV Y
Sbjct: 8 QKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK-HPNIVQY 66
Query: 112 LDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQ 171
+ S +N + I+M+YC G + ++N + F E ++L F C A+ +H
Sbjct: 67 RE----SFEEN-GSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHD 121
Query: 172 CKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRA 231
K I+HRD+K +NI L G L DFG A + LN + VE T Y +
Sbjct: 122 RK--ILHRDIKSQNIFLTKDGTVQLGDFGIA--RVLN------STVELARTCIGTPYYLS 171
Query: 232 PEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRY 286
PE+ KP K+DIWALGC+LY+LC F + I G+F P + Y
Sbjct: 172 PEICE---NKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFP-PVSLHY 227
Query: 287 SRNIHCLIRFMLEPDPEHRPDI 308
S ++ L+ + + +P RP +
Sbjct: 228 SYDLRSLVSQLFKRNPRDRPSV 249
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 96.3 bits (238), Expect = 2e-19
Identities = 85/333 (25%), Positives = 143/333 (42%), Gaps = 30/333 (9%)
Query: 57 LAEGGFSTVFLVRTHGGIRC-ALKRMYV-NNMPDLNVCKREITIMKELSGHKNIVGYLDC 114
+ EG F LV+ + A+K + + + + ++E ++ ++ H NIV + +
Sbjct: 10 IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKES 68
Query: 115 AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKT 174
+ + I+MEYC G ++ ++ ++ F E +L F C V +H K
Sbjct: 69 F-----EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH--KK 121
Query: 175 PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEM 234
++HRD+K +NI L G L DFGSA NP V T Y PE
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPPE- 172
Query: 235 INLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRN 289
++ P K+DIW+LGC+LY+LC PF + + +C G + P S YS
Sbjct: 173 --IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYSYE 229
Query: 290 IHCLIRFMLEPDPEHRPDIFQV--SYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAA 347
+ L++ M + +P HRP + + +K P I L E +
Sbjct: 230 LQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYG-EEVLEEIKNSKHNT 288
Query: 348 ARKSQIKARITDTIGPTETSIAPRQRPKANSAT 380
RK +RI +G +++ ++ + S T
Sbjct: 289 PRKKTNPSRIRIALGNEASTVQEEEQDRKGSHT 321
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 96.3 bits (238), Expect = 2e-19
Identities = 85/333 (25%), Positives = 143/333 (42%), Gaps = 30/333 (9%)
Query: 57 LAEGGFSTVFLVRTHGGIRC-ALKRMYV-NNMPDLNVCKREITIMKELSGHKNIVGYLDC 114
+ EG F LV+ + A+K + + + + ++E ++ ++ H NIV + +
Sbjct: 10 IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKES 68
Query: 115 AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKT 174
+ + I+MEYC G ++ ++ ++ F E +L F C V +H K
Sbjct: 69 F-----EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH--KK 121
Query: 175 PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEM 234
++HRD+K +NI L G L DFGSA NP V T Y PE
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPPE- 172
Query: 235 INLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRN 289
++ P K+DIW+LGC+LY+LC PF + + +C G + P S YS
Sbjct: 173 --IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYSYE 229
Query: 290 IHCLIRFMLEPDPEHRPDIFQV--SYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAA 347
+ L++ M + +P HRP + + +K P I L E +
Sbjct: 230 LQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYG-EEVLEEIKNSKHNT 288
Query: 348 ARKSQIKARITDTIGPTETSIAPRQRPKANSAT 380
RK +RI +G +++ ++ + S T
Sbjct: 289 PRKKTNPSRIRIALGNEASTVQEEEQDRKGSHT 321
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 95.9 bits (237), Expect = 2e-19
Identities = 73/257 (28%), Positives = 119/257 (46%), Gaps = 27/257 (10%)
Query: 57 LAEGGFSTVFLVRTHGGIRC-ALKRMYV-NNMPDLNVCKREITIMKELSGHKNIVGYLDC 114
+ EG F LV+ + A+K + + + + ++E ++ ++ H NIV + +
Sbjct: 10 IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKES 68
Query: 115 AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKT 174
+ + I+MEYC G ++ ++ ++ F E +L F C V +H K
Sbjct: 69 F-----EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH--KK 121
Query: 175 PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEM 234
++HRD+K +NI L G L DFGSA NP V T Y PE
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPPE- 172
Query: 235 INLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRN 289
++ P K+DIW+LGC+LY+LC PF + + +C G + P S YS
Sbjct: 173 --IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYSYE 229
Query: 290 IHCLIRFMLEPDPEHRP 306
+ L++ M + +P HRP
Sbjct: 230 LQFLVKQMFKRNPSHRP 246
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 95.1 bits (235), Expect = 3e-19
Identities = 175/824 (21%), Positives = 308/824 (37%), Gaps = 141/824 (17%)
Query: 53 LEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGY 111
L E + G + V+ R G A+K M V + + K EI ++K+ S H+NI Y
Sbjct: 27 LVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KLEINMLKKYSHHRNIATY 85
Query: 112 LDCAVNSI----SDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 167
+ D +W ++ME+C AG + + + E + I + +A
Sbjct: 86 YGAFIKKSPPGHDDQLW---LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 142
Query: 168 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 227
LH +IHRD+K +N+LL + L DFG ++ Q D V T
Sbjct: 143 HLHIHH--VIHRDIKGQNVLLTENAEVKLVDFG------VSAQLD--RTVGRRNTFIGTP 192
Query: 228 SYRAPEMINLYGGKPITT--KADIWALGCLLYKLCFFTLPFGESQVAICDGN-----FTI 280
+ APE+I T ++D+W+ G ++ E +CD + F I
Sbjct: 193 YWMAPEVIACDENPDATYDYRSDLWSCGITAIEMA-------EGAPPLCDMHPMRALFLI 245
Query: 281 PDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSN-INNSSIPSALPE 339
P N P P + + +F+F + C V N + S L
Sbjct: 246 PRN----------------PPPRLKSKKWSKKFFSFI---EGCLVKNYMQRPSTEQLLKH 286
Query: 340 PMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVL 399
P + R Q++ ++ D I T + + + + + P ++
Sbjct: 287 PFIRDQPNER--QVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIV 344
Query: 400 -APGEFGNHRPKGALRPGNGP--------EILLGQGPPQQPPQQHRVLQQLQQGDWRLQQ 450
PGE R L+ N ++L Q +Q + ++L + Q+ R++Q
Sbjct: 345 NVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQK---RIEQ 401
Query: 451 LHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQ----------------------QQQQQHH 488
Q R +QQ+++++ ++QQ+++Q++++Q +++++
Sbjct: 402 QKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461
Query: 489 HHHHHHLLQDAYMQQYQHATQQQQMLQQQ-FLMHSVYQPQPSASQYPTMMPQYQQ---AF 544
++ + +Q QQQ+LQ+Q L+H +P P SQ P PQ ++ +F
Sbjct: 462 EREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPP-PPQQERSKPSF 520
Query: 545 FQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIM-------------- 590
+ A ++P+ + E F S + Q G ++
Sbjct: 521 HAPEPKAHYEPADRAREVE-----DRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNG 575
Query: 591 --DSSYSANRSVADKEAIANFTNQKNI----SNPPDMSGW--NPFGEDNFSKLTEEELLD 642
+S + A + A+ + T++ + +P SG + G+ N + E LL
Sbjct: 576 NSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLW 635
Query: 643 REFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQE 702
+ L SS + +S S P +HP S SGS E+ SS E
Sbjct: 636 ERVEKLVPR--PGSGSSSGSSNSGSQPGSHPG----------SQSGSGERFRVRSSSKSE 683
Query: 703 NGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDESESDFESDPPSP-------KSSE 755
+ ++N P K + + G+V E D P SSE
Sbjct: 684 GSPSQRLENAVKKPEDK-KEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSE 742
Query: 756 EEEQDDEEVLQGEQGDFNDDDTEPENLGHRPLLMDSEDEEEEEK 799
E DEE EQ ++ + PE+ L S E E K
Sbjct: 743 ESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVK 786
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 94.7 bits (234), Expect = 4e-19
Identities = 162/776 (20%), Positives = 297/776 (38%), Gaps = 124/776 (15%)
Query: 53 LEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGY 111
L E + G + V+ R G A+K M V + + K EI ++K+ S H+NI Y
Sbjct: 27 LVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KLEINMLKKYSHHRNIATY 85
Query: 112 LDCAVNSI----SDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 167
+ D +W ++ME+C AG + + + E + I + +A
Sbjct: 86 YGAFIKKSPPGHDDQLW---LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 142
Query: 168 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 227
LH +IHRD+K +N+LL + L DFG ++ Q D V T
Sbjct: 143 HLHIHH--VIHRDIKGQNVLLTENAEVKLVDFG------VSAQLD--RTVGRRNTFIGTP 192
Query: 228 SYRAPEMINLYGGKPITT--KADIWALGCLLYKLCFFTLPFGESQVAICDGN-----FTI 280
+ APE+I T ++D+W+ G ++ E +CD + F I
Sbjct: 193 YWMAPEVIACDENPDATYDYRSDLWSCGITAIEMA-------EGAPPLCDMHPMRALFLI 245
Query: 281 PDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSN-INNSSIPSALPE 339
P N P P + + +F+F + C V N + S L
Sbjct: 246 PRN----------------PPPRLKSKKWSKKFFSFI---EGCLVKNYMQRPSTEQLLKH 286
Query: 340 PMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVL 399
P + R Q++ ++ D I T + + + + + P ++
Sbjct: 287 PFIRDQPNER--QVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIV 344
Query: 400 -APGEFGNHRPKGALRPGNGP--------EILLGQGPPQQPPQQHRVLQQLQQGDWRLQQ 450
PGE R L+ N ++L Q +Q + ++L + Q+ R++Q
Sbjct: 345 NVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQK---RIEQ 401
Query: 451 LHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQ----------------------QQQQQHH 488
Q R +QQ+++++ ++QQ+++Q++++Q +++++
Sbjct: 402 QKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461
Query: 489 HHHHHHLLQDAYMQQYQHATQQQQMLQQQ-FLMHSVYQPQPSASQYPTMMPQYQQ---AF 544
++ + +Q QQQ+LQ+Q L+H +P P SQ P PQ ++ +F
Sbjct: 462 EREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPP-PPQQERSKPSF 520
Query: 545 FQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKE 604
+ A ++P+ + T+ + SP L S P Q +S S + E
Sbjct: 521 HAPEPKAHYEPADRAREVPVRTTSR--SPVLSRRDS--PLQGSGQQNSQAGQRNSTSSIE 576
Query: 605 AIANFTNQKNISNPP---DMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDK 661
+ + + P SG + G S + F +RS+ E + S +
Sbjct: 577 PRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERF-RVRSSSKSEGSPSQR 635
Query: 662 NVDSLSAPHNHP----PEDPFGSVPF---------ISHSGSPEKKAEHSSINQENGTANP 708
+++ P + P P G V + P K ++SS ++E+GT +
Sbjct: 636 LENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDE 695
Query: 709 IKNGKTSPASKDQRTG-KKTSVQGQVQKGNDESES--------DFESDPPSPKSSE 755
+ + + +G + T + N E+ES D ES+P S E
Sbjct: 696 EDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKE 751
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 92.4 bits (228), Expect = 2e-18
Identities = 96/387 (24%), Positives = 177/387 (45%), Gaps = 44/387 (11%)
Query: 48 RHQVTLEESLAEGGFSTVFLVRTHGGIRC----ALKRMYVNNMPDLNVCKREITIMKELS 103
+H+ L+E+L +G + V R ++++ + + D+ +REI IM L+
Sbjct: 52 KHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLN 111
Query: 104 GHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTC 163
H +I+ ++ + +N +++I+MEY G++ + ++++ + +E E F
Sbjct: 112 -HPHII-----SIYEVFENKDKIVIIMEYASKGELYDYISERRR--LSERETRHFFRQIV 163
Query: 164 EAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKK 223
AV H K ++HRDLK+ENILL+D N + DFG +N + QKD + ++
Sbjct: 164 SAVHYCH--KNGVVHRDLKLENILLDDNCNIKIADFG-LSNLY---QKD------KFLQT 211
Query: 224 YT-TLSYRAPEMINLYGGKPIT-TKADIWALGCLLYKLCFFTLPFGESQ-----VAICDG 276
+ + Y +PE++N G+P + D WALG LLY L + T+PF I G
Sbjct: 212 FCGSPLYASPEIVN---GRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSG 268
Query: 277 NFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVS---YFAFKFAKKDCPVSNINNSSI 333
+ P +R LIR+ML +P+ R I ++ + + + C +++S
Sbjct: 269 EYREPTQPSDARG---LIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSES 325
Query: 334 PSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSA 393
P + ++ +A++ PT TS +R ++ + A
Sbjct: 326 PLLARIIDWHHRSTGLQADTEAKMKGLAKPT-TSEVMLERQRSLKKSKKENDFAQSGQDA 384
Query: 394 TPVKVLAPGEFGNHRPKGALRPGNGPE 420
P +P + + RPKG L+ + E
Sbjct: 385 VPE---SPSKLSSKRPKGILKKRSNSE 408
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 90.1 bits (222), Expect = 1e-17
Identities = 76/274 (27%), Positives = 129/274 (47%), Gaps = 36/274 (13%)
Query: 53 LEESLAEGGFSTVFLVRTH-GGIRCALKRMYVNNMPDLNV---CKREITIMKELSGHKNI 108
+E+ + G FS V+ G+ ALK++ + ++ D C +EI ++K+L+ H N+
Sbjct: 36 IEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN-HPNV 94
Query: 109 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMN--KKLQTGFTEPEVLQIFCDTCEAV 166
+ Y + I DN E+ I++E AG + + KK + E V + F C A+
Sbjct: 95 IKYY---ASFIEDN--ELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149
Query: 167 ARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 226
+H + ++HRD+K N+ + G L D G +F + + + + T
Sbjct: 150 EHMHSRR--VMHRDIKPANVFITATGVVKLGDLG--LGRFFSSKTTAAHSL------VGT 199
Query: 227 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GE--------SQVAICDGN 277
Y +PE I+ G K+DIW+LGCLLY++ PF G+ ++ CD
Sbjct: 200 PYYMSPERIHENG---YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCD-- 254
Query: 278 FTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 311
+ + YS + L+ + PDPE RPD+ V
Sbjct: 255 YPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 90.1 bits (222), Expect = 1e-17
Identities = 72/227 (31%), Positives = 113/227 (49%), Gaps = 34/227 (14%)
Query: 48 RHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMY---VNNMPDLNVCKREITIMKELSG 104
RH+ E+L +G + V R G A+K + + + DL +REI IM L+
Sbjct: 50 RHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLN- 108
Query: 105 HKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCE 164
H +I+ A++ + +N +++I+MEY G + + ++++ Q +E E F
Sbjct: 109 HPHII-----AIHEVFENSSKIVIVMEYASRGDLYDYISERQQ--LSEREARHFFRQIVS 161
Query: 165 AVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSAT----NKFLNPQKDGVNVVEEE 220
AV HQ + ++HRDLK+ENILL+ GN + DFG + KFL
Sbjct: 162 AVHYCHQNR--VVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQ------------ 207
Query: 221 IKKYTTLSYRAPEMINLYGGKPIT-TKADIWALGCLLYKLCFFTLPF 266
+ Y +PE++N GKP T + D W+LG LLY L T+PF
Sbjct: 208 -TFCGSPLYASPEIVN---GKPYTGPEVDSWSLGVLLYILVHGTMPF 250
>gi|110347429 mediator complex subunit 12 [Homo sapiens]
Length = 2177
Score = 89.7 bits (221), Expect = 1e-17
Identities = 52/105 (49%), Positives = 57/105 (54%), Gaps = 1/105 (0%)
Query: 458 PHQQQQQQQQQQQQQQQQQQQQQQQQQQQH-HHHHHHHLLQDAYMQQYQHATQQQQMLQQ 516
P QQQQQQQQQQQQQQQQQQQQQQQQQQ H +L+ QQ Q QQQQ QQ
Sbjct: 2049 PEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQ 2108
Query: 517 QFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQAS 561
Q +Q Q P Q FQ+Q L Q Q QQ A+
Sbjct: 2109 QQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAA 2153
Score = 84.0 bits (206), Expect = 8e-16
Identities = 59/129 (45%), Positives = 67/129 (51%), Gaps = 21/129 (16%)
Query: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQ---QQQQQQQQQQQQQQQQQ 477
IL Q QQ QQ + QQ QQ + QQ H++ + Q QQQQQQQQQQQQQQQQQ
Sbjct: 2047 ILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQ 2106
Query: 478 QQQQQQQQQHHHHHHHHLL--------QDAYMQQYQHATQQQQ-------MLQQQFLMHS 522
QQQQQQQQQH Q + +Q TQQQQ LQQQ S
Sbjct: 2107 QQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQL---S 2163
Query: 523 VYQPQPSAS 531
QPQPS +
Sbjct: 2164 NTQPQPSTN 2172
Score = 82.8 bits (203), Expect = 2e-15
Identities = 64/145 (44%), Positives = 69/145 (47%), Gaps = 28/145 (19%)
Query: 428 PQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQ--QQQQQQQQQQQQQQQQQQQQ 485
P+Q QQ + QQ QQ + QQ Q H QQQQQQ +QQQQQQQQQQQQQQQQQQQ
Sbjct: 2049 PEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQ 2108
Query: 486 QHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQ-YQQAF 544
Q QQ QH QQQQ PQP P Q QQ
Sbjct: 2109 QQ-------------QQQQQHQQQQQQ---------QAAPPQPQPQSQPQFQRQGLQQTQ 2146
Query: 545 FQQQMLAQHQPSQQQASPEYLTSPQ 569
QQQ A + QQQ S T PQ
Sbjct: 2147 QQQQTAALVRQLQQQLSN---TQPQ 2168
Score = 57.0 bits (136), Expect = 1e-07
Identities = 42/110 (38%), Positives = 51/110 (46%), Gaps = 10/110 (9%)
Query: 473 QQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQ 532
+QQQQQQQQQQQQQ Q Y + Q QQQQ+L+QQ Q Q Q
Sbjct: 2050 EQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQ---QQQQILRQQQQQQQQQQQQQQQQQ 2106
Query: 533 YPTMMPQYQQAFFQQQMLAQHQPSQQQASPEY------LTSPQEFSPALV 576
Q Q QQQ A QP Q Q+ P++ T Q+ + ALV
Sbjct: 2107 QQQQQQQQQHQQQQQQQAAPPQP-QPQSQPQFQRQGLQQTQQQQQTAALV 2155
Score = 43.5 bits (101), Expect = 0.001
Identities = 46/185 (24%), Positives = 60/185 (32%), Gaps = 11/185 (5%)
Query: 389 IQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRL 448
+Q P + P + + +P + P P ++ P +H LQQ G
Sbjct: 1953 LQQHTGPAGTMVPPSYSS-QPYQSTHPSTNPTLV--------DPTRH--LQQRPSGYVHQ 2001
Query: 449 QQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHAT 508
Q H Q+ Q QQ Q Q L + QQ Q
Sbjct: 2002 QAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQ 2061
Query: 509 QQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSP 568
QQQQ QQQ Y + Q Q QQ QQQ Q Q QQQ
Sbjct: 2062 QQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQ 2121
Query: 569 QEFSP 573
Q+ +P
Sbjct: 2122 QQAAP 2126
Score = 32.7 bits (73), Expect = 2.1
Identities = 31/205 (15%), Positives = 74/205 (36%), Gaps = 22/205 (10%)
Query: 665 SLSAPHNHPPEDPFGSV----PFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD 720
+L P H + P G V P H + ++ H ++ Q P+ + T +++
Sbjct: 1983 TLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQ-----TPMISTMTPMSAQG 2037
Query: 721 QRTGKKTSV------QGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFND 774
+ G +++ Q Q Q+ + + + + +Q +++L+ +Q
Sbjct: 2038 VQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQ 2097
Query: 775 DDTEPENLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNT 834
+ + + ++++++H + A + S R G TQ
Sbjct: 2098 QQQQQQQ-------QQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQ 2150
Query: 835 ILLTSAQLSSDVAVETPKQEFDVFG 859
QL ++ P+ ++FG
Sbjct: 2151 TAALVRQLQQQLSNTQPQPSTNIFG 2175
Score = 32.3 bits (72), Expect = 2.7
Identities = 38/153 (24%), Positives = 52/153 (33%), Gaps = 14/153 (9%)
Query: 459 HQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHH-----HHHHLLQDAYMQQYQHATQQQQM 513
++QQQ Q Q+ +QQ QQ Q Q H + Y H QQ
Sbjct: 1898 YRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHT 1957
Query: 514 LQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPS--QQQASPEY---LTSP 568
++ Y QP S +P+ P Q +PS Q +P Y LTS
Sbjct: 1958 GPAGTMVPPSYSSQPYQSTHPSTNP----TLVDPTRHLQQRPSGYVHQQAPTYGHGLTST 2013
Query: 569 QEFSPALVSYTSSLPAQVGTIMDSSYSANRSVA 601
Q FS + T + + RS A
Sbjct: 2014 QRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTA 2046
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 88.6 bits (218), Expect = 3e-17
Identities = 79/276 (28%), Positives = 128/276 (46%), Gaps = 32/276 (11%)
Query: 53 LEESLAEGGFSTVFLVRTHGGIRC-ALKRMYVNNMPDLNV---CKREITIMKELSGHKNI 108
+E+ + G FS V+ + ALK++ + M D C +EI ++K+L+ H NI
Sbjct: 81 IEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPNI 139
Query: 109 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMN--KKLQTGFTEPEVLQIFCDTCEAV 166
+ YLD + I DN E+ I++E AG + + KK + E V + F C AV
Sbjct: 140 IKYLD---SFIEDN--ELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 194
Query: 167 ARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 226
+H + ++HRD+K N+ + G L D G +F + + + + T
Sbjct: 195 EHMHSRR--VMHRDIKPANVFITATGVVKLGDLG--LGRFFSSETTAAHSL------VGT 244
Query: 227 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQV---AICDG----NFT 279
Y +PE I+ G K+DIW+LGCLLY++ PF ++ ++C ++
Sbjct: 245 PYYMSPERIHENG---YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYP 301
Query: 280 IPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFA 315
YS + L+ + PDP RPDI V A
Sbjct: 302 PLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVA 337
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 88.6 bits (218), Expect = 3e-17
Identities = 79/276 (28%), Positives = 128/276 (46%), Gaps = 32/276 (11%)
Query: 53 LEESLAEGGFSTVFLVRTHGGIRC-ALKRMYVNNMPDLNV---CKREITIMKELSGHKNI 108
+E+ + G FS V+ + ALK++ + M D C +EI ++K+L+ H NI
Sbjct: 47 IEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPNI 105
Query: 109 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMN--KKLQTGFTEPEVLQIFCDTCEAV 166
+ YLD + I DN E+ I++E AG + + KK + E V + F C AV
Sbjct: 106 IKYLD---SFIEDN--ELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 160
Query: 167 ARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 226
+H + ++HRD+K N+ + G L D G +F + + + + T
Sbjct: 161 EHMHSRR--VMHRDIKPANVFITATGVVKLGDLG--LGRFFSSETTAAHSL------VGT 210
Query: 227 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQV---AICDG----NFT 279
Y +PE I+ G K+DIW+LGCLLY++ PF ++ ++C ++
Sbjct: 211 PYYMSPERIHENG---YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYP 267
Query: 280 IPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFA 315
YS + L+ + PDP RPDI V A
Sbjct: 268 PLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVA 303
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 85.5 bits (210), Expect = 3e-16
Identities = 75/234 (32%), Positives = 98/234 (41%), Gaps = 33/234 (14%)
Query: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFG--------------- 405
+GP + ++ +Q P A VL QS LA G
Sbjct: 3802 LGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQ 3861
Query: 406 -NHRPKGALRPGNGPE--ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ 462
H+ +G++ + + ++ G P+ Q LQQLQQ QQ LQ + Q Q
Sbjct: 3862 QQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQ 3921
Query: 463 QQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHS 522
QQQQ QQQQ QQQQQQQQ QQQQQ QQ Q QQQQ QQQF
Sbjct: 3922 QQQQLQQQQLQQQQQQQQLQQQQQQQ-----------LQQQQQQLQQQQQQQQQQFQQQQ 3970
Query: 523 VYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALV 576
Q +Q T++ QQ QQQ +A P ++ +SP P L+
Sbjct: 3971 QQQQMGLLNQSRTLLSPQQQ---QQQQVAL-GPGMPAKPLQHFSSPGALGPTLL 4020
Score = 49.7 bits (117), Expect = 2e-05
Identities = 71/231 (30%), Positives = 88/231 (38%), Gaps = 37/231 (16%)
Query: 367 SIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHR--PKGALRPGNGPEILLG 424
+++P Q P+ T P L P + G+ G R P G PG L
Sbjct: 3618 ALSPSQSPRL---LTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMALPGQPGGPFLN 3674
Query: 425 QGPPQQPPQQHR--------VLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQ 476
QQ QQH G+ L+ L R ++Q Q QQQ+ Q Q+
Sbjct: 3675 TALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKL 3734
Query: 477 QQQQQQQQQQHHHHHHHHLLQDAYMQQYQH---ATQQQQML--QQQFLMHS-------VY 524
QQQQQQQQQQ HLL +QQ Q Q Q L + Q LM V
Sbjct: 3735 QQQQQQQQQQ------QHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQ 3788
Query: 525 QPQPSASQYPT-MMPQYQQAFFQQQ---MLAQHQPSQQ--QASPEYLTSPQ 569
Q P Q P M+ Q A QQQ L P +Q L+SPQ
Sbjct: 3789 QLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQ 3839
Score = 42.4 bits (98), Expect = 0.003
Identities = 48/156 (30%), Positives = 70/156 (44%), Gaps = 12/156 (7%)
Query: 459 HQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQF 518
H++++ Q++QQ Q Q QQQQQQQQQH Q A ++ ++ QQQ
Sbjct: 3255 HEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQ-AMSLPHEGSSPSLAGSQQQL 3313
Query: 519 LMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPE-YLTSPQEFSPA-LV 576
+ QP Q +MP A QQ LA PS S + ++ S Q A LV
Sbjct: 3314 SLGLAGARQPGLPQ--PLMPTQPPAHALQQRLA---PSMAMVSNQGHMLSGQHGGQAGLV 3368
Query: 577 SYTSSLPA----QVGTIMDSSYSANRSVADKEAIAN 608
SS P +GT+ S + +A ++ +AN
Sbjct: 3369 PQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLAN 3404
Score = 38.5 bits (88), Expect = 0.038
Identities = 20/44 (45%), Positives = 29/44 (65%), Gaps = 5/44 (11%)
Query: 449 QQLHLQHRHPHQQQQQQQQ-----QQQQQQQQQQQQQQQQQQQH 487
QQ +Q + ++QQ++ + + +QQQQQQQQQQQQQQH
Sbjct: 3570 QQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQH 3613
Score = 37.0 bits (84), Expect = 0.11
Identities = 19/46 (41%), Positives = 27/46 (58%)
Query: 437 VLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQ 482
V +Q + +L Q+ Q + + + +QQQQQQQQQQQQQQ
Sbjct: 3567 VTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQ 3612
Score = 36.6 bits (83), Expect = 0.14
Identities = 23/45 (51%), Positives = 29/45 (64%), Gaps = 7/45 (15%)
Query: 433 QQHRVLQQLQQGDWRLQQ-----LHLQHRHPHQQQQQQQQQQQQQ 472
QQ ++ +QL Q R QQ L ++R+ QQQQQQQQQQQQQ
Sbjct: 3570 QQSKIQKQLDQV--RKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQ 3612
Score = 36.6 bits (83), Expect = 0.14
Identities = 17/39 (43%), Positives = 22/39 (56%)
Query: 450 QLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHH 488
Q L Q++ + + +QQQQQQQQQQQQQ H
Sbjct: 3575 QKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQH 3613
Score = 35.4 bits (80), Expect = 0.32
Identities = 15/30 (50%), Positives = 20/30 (66%)
Query: 460 QQQQQQQQQQQQQQQQQQQQQQQQQQQHHH 489
QQ++ + + +QQQQQQQQQQQQ H
Sbjct: 3584 QQKEHTNLMAEYRNKQQQQQQQQQQQQQQH 3613
Score = 34.7 bits (78), Expect = 0.54
Identities = 42/173 (24%), Positives = 73/173 (42%), Gaps = 16/173 (9%)
Query: 416 GNGPEILLGQGPPQQPPQQHRVLQQ--LQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQ 473
G+G E G P QP Q + + D R + L H Q Q + ++Q
Sbjct: 3477 GSGQE--RSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGV 3534
Query: 474 QQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQY 533
++ ++ +Q+ +A ++ + T+QQ +Q+Q + Q + ++
Sbjct: 3535 HRKSRKALCAKQRTAKKAGREF-PEADAEKLKLVTEQQSKIQKQ-----LDQVRKQQKEH 3588
Query: 534 PTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQV 586
+M +Y+ QQQ Q Q QQQ S SP + SP L+ + LP Q+
Sbjct: 3589 TNLMAEYRNK--QQQQQQQQQQQQQQHSAVLALSPSQ-SPRLL---TKLPGQL 3635
Score = 33.5 bits (75), Expect = 1.2
Identities = 38/112 (33%), Positives = 48/112 (42%), Gaps = 9/112 (8%)
Query: 382 ATPSV-LTIQSSATPVKVLAPGEFGNHRPK----GALRPGNGPEILLGQGPPQQP--PQQ 434
A PSV L Q + +L P + RP G P GP + GQG P P
Sbjct: 4135 AQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTV 4194
Query: 435 HRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQ 486
++ QLQ + QL +H P QQQQ Q Q+Q QQ Q +Q Q
Sbjct: 4195 GQLRAQLQGVLAKNPQL--RHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQ 4244
Score = 32.0 bits (71), Expect = 3.5
Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 15/95 (15%)
Query: 468 QQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQ 527
+QQ + Q+Q Q ++QQ++H + L Y + Q QQQQ QQQ HS
Sbjct: 3569 EQQSKIQKQLDQVRKQQKEHTN------LMAEYRNKQQQQQQQQQQQQQQ---HSAVLAL 3619
Query: 528 PSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASP 562
S SQ P ++ + Q+L H Q P
Sbjct: 3620 -SPSQSPRLLTK-----LPGQLLPGHGLQPPQGPP 3648
>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
Length = 788
Score = 84.0 bits (206), Expect = 8e-16
Identities = 76/225 (33%), Positives = 87/225 (38%), Gaps = 49/225 (21%)
Query: 411 GALRPGNGPEILLGQGPP----QQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466
G+L P L GQ PP P V Q +LQQ+ LQ + QQ QQQQ
Sbjct: 114 GSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQ 173
Query: 467 QQQQQQQQQQQQQ------------------------QQQQQQQHH----HHHHHHLLQD 498
Q QQQQQQQQQ QQQQQQQ H HH + +Q
Sbjct: 174 QAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQ 233
Query: 499 AYMQ-----QYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQ- 552
Q Q Q QQQQ QQQ Q QP Q P PQ + Q L Q
Sbjct: 234 QQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQM 293
Query: 553 -----HQPSQQQASPEYLTS------PQEFSPALVSYTSSLPAQV 586
HQP Q P + PQ + LVS +LP Q+
Sbjct: 294 HHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQM 338
Score = 39.3 bits (90), Expect = 0.022
Identities = 50/195 (25%), Positives = 65/195 (33%), Gaps = 41/195 (21%)
Query: 420 EILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLH-LQHRHPHQQQQQQQQQQQQQQQQQQQ 478
+ L Q P QQPP Q Q +LQQ+H QH P Q QQ Q Q Q Q
Sbjct: 262 QALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQ 321
Query: 479 QQQQQQQQHHHHHHHHLLQ-------------------DAYMQQYQHATQQQQMLQQ--- 516
Q Q +L +QQ Q A Q Q Q
Sbjct: 322 SQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAP 381
Query: 517 ----------QFLMH--SVYQPQPSASQYPTM------MPQYQQAFFQQQMLAQHQPSQQ 558
Q MH + + P + S P+ P Q + ML+ P QQ
Sbjct: 382 GVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQ 441
Query: 559 QASPEYLTSPQEFSP 573
+P+ + P + SP
Sbjct: 442 VQTPQSMPPPPQPSP 456
Score = 31.6 bits (70), Expect = 4.6
Identities = 29/126 (23%), Positives = 51/126 (40%), Gaps = 14/126 (11%)
Query: 324 PVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTAT 383
P++ ++ SS+P M +S + ++ Q + P+ P +P +N ++
Sbjct: 421 PMAQVSQSSLP------MLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA 474
Query: 384 PSVLTI------QSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRV 437
PS + Q S +PV P F P P N ++ G Q QQ+
Sbjct: 475 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY-- 532
Query: 438 LQQLQQ 443
L +L+Q
Sbjct: 533 LDKLKQ 538
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 84.0 bits (206), Expect = 8e-16
Identities = 76/225 (33%), Positives = 87/225 (38%), Gaps = 49/225 (21%)
Query: 411 GALRPGNGPEILLGQGPP----QQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466
G+L P L GQ PP P V Q +LQQ+ LQ + QQ QQQQ
Sbjct: 114 GSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQ 173
Query: 467 QQQQQQQQQQQQQ------------------------QQQQQQQHH----HHHHHHLLQD 498
Q QQQQQQQQQ QQQQQQQ H HH + +Q
Sbjct: 174 QAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQ 233
Query: 499 AYMQ-----QYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQ- 552
Q Q Q QQQQ QQQ Q QP Q P PQ + Q L Q
Sbjct: 234 QQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQM 293
Query: 553 -----HQPSQQQASPEYLTS------PQEFSPALVSYTSSLPAQV 586
HQP Q P + PQ + LVS +LP Q+
Sbjct: 294 HHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQM 338
Score = 74.3 bits (181), Expect = 6e-13
Identities = 64/187 (34%), Positives = 80/187 (42%), Gaps = 36/187 (19%)
Query: 433 QQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQ--QQQQQQQQQQQQQQQQQQHHHH 490
QQ + LQQ QQ L +LH Q++ QQQQQQ Q+ Q Q QQQQQQQQQQQQQQ
Sbjct: 205 QQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQAL 264
Query: 491 HHHHLLQDAYMQQYQHATQQ---QQMLQQQFLMHSVYQPQPS----ASQYPTMMPQYQQA 543
+Q MQQ Q Q QQ+ Q H PQP A P+ +P Q
Sbjct: 265 QAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQT 324
Query: 544 ----------------------FFQQQMLAQHQP-----SQQQASPEYLTSPQEFSPALV 576
F + M+ Q P QQQ + + + Q +P +
Sbjct: 325 QPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ 384
Query: 577 SYTSSLP 583
SSLP
Sbjct: 385 VSQSSLP 391
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 83.2 bits (204), Expect = 1e-15
Identities = 71/228 (31%), Positives = 109/228 (47%), Gaps = 28/228 (12%)
Query: 95 EITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNK--KLQTGFTE 152
E+ +++EL H NIV Y D ++ + ++ I+MEYC G + + + K K + E
Sbjct: 55 EVNLLRELK-HPNIVRYYDRIIDRTNTTLY---IVMEYCEGGDLASVITKGTKERQYLDE 110
Query: 153 PEVLQIFCDTCEAVARLHQCKT---PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNP 209
VL++ A+ H+ ++HRDLK N+ L+ N L DFG A + LN
Sbjct: 111 EFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLA--RILNH 168
Query: 210 QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLP---F 266
T Y +PE +N K+DIW+LGCLLY+LC P F
Sbjct: 169 DTSFAKTF------VGTPYYMSPEQMNRMS---YNEKSDIWSLGCLLYELCALMPPFTAF 219
Query: 267 GESQVA--ICDGNF-TIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 311
+ ++A I +G F IP RYS ++ +I ML HRP + ++
Sbjct: 220 SQKELAGKIREGKFRRIP--YRYSDELNEIITRMLNLKDYHRPSVEEI 265
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 82.8 bits (203), Expect = 2e-15
Identities = 71/242 (29%), Positives = 113/242 (46%), Gaps = 29/242 (11%)
Query: 78 LKRMYVNNMP--DLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRA 135
+K++ V M + + E ++K L+ H N++ Y + N + D ++I MEY
Sbjct: 32 IKQIPVEQMTKEERQAAQNECQVLKLLN-HPNVIEYYE---NFLEDKA--LMIAMEYAPG 85
Query: 136 GQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV 195
G + + K+ + E +L F A+ +H I+HRDLK +NILL+ V
Sbjct: 86 GTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL--ILHRDLKTQNILLDKHRMVV 143
Query: 196 -LCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGC 254
+ DFG +K L+ + VV T Y +PE+ GKP K+DIWALGC
Sbjct: 144 KIGDFG--ISKILSSKSKAYTVVG-------TPCYISPELCE---GKPYNQKSDIWALGC 191
Query: 255 LLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIF 309
+LY+L F + + I G F P + RYS + L+ +L +P RP +
Sbjct: 192 VLYELASLKRAFEAANLPALVLKIMSGTFA-PISDRYSPELRQLVLSLLSLEPAQRPPLS 250
Query: 310 QV 311
+
Sbjct: 251 HI 252
>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
Length = 715
Score = 82.4 bits (202), Expect = 2e-15
Identities = 66/197 (33%), Positives = 84/197 (42%), Gaps = 13/197 (6%)
Query: 378 SATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRV 437
S+ P + + + +V+ P + + L P +L Q QQ +
Sbjct: 78 SSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQE 137
Query: 438 LQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQ 497
+ QQ LQ L Q + QQQQQQQQQQQQQQQQQQQQQQQQQQQ H
Sbjct: 138 FYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQA 197
Query: 498 DAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQ 557
QQ Q QQQQ+ QQ + Q Q + Q Q+Q L P Q
Sbjct: 198 KEQQQQQQ---QQQQLAAQQLVF------QQQLLQMQQLQQQQHLLSLQRQGLISIPPGQ 248
Query: 558 Q----QASPEYLTSPQE 570
Q+ P+ SP E
Sbjct: 249 AALPVQSLPQAGLSPAE 265
>gi|226246533 TOX high mobility group box family member 3 isoform 2
[Homo sapiens]
Length = 571
Score = 82.4 bits (202), Expect = 2e-15
Identities = 51/124 (41%), Positives = 59/124 (47%), Gaps = 16/124 (12%)
Query: 461 QQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLM 520
QQ Q Q QQQQQQQQQQ QQ QQQQ H H + Q Q +QH QQ QQQ L
Sbjct: 434 QQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQ 493
Query: 521 HSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTS 580
+ Q Q QQ Q+ L Q Q Q Q+ P SP++ SP TS
Sbjct: 494 QQINQ------------QQLQQQLQQRLQLQQLQHMQHQSQP----SPRQHSPVASQITS 537
Query: 581 SLPA 584
+PA
Sbjct: 538 PIPA 541
Score = 77.8 bits (190), Expect = 6e-14
Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 10/135 (7%)
Query: 440 QLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHH-----HH 494
Q QQ +LQQ Q + QQ QQQQ QQ Q QQ QQQ QQQ QHH H H
Sbjct: 432 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 491
Query: 495 LLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQ 554
L Q QQ Q Q QQ LQ Q L H +Q QPS Q+ + Q + Q
Sbjct: 492 LQQQINQQQLQQ--QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPI---PAIGSPQ 546
Query: 555 PSQQQASPEYLTSPQ 569
P+ QQ + + Q
Sbjct: 547 PASQQHQSQIQSQTQ 561
>gi|226054295 TOX high mobility group box family member 3 isoform 1
[Homo sapiens]
Length = 576
Score = 82.4 bits (202), Expect = 2e-15
Identities = 51/124 (41%), Positives = 59/124 (47%), Gaps = 16/124 (12%)
Query: 461 QQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLM 520
QQ Q Q QQQQQQQQQQ QQ QQQQ H H + Q Q +QH QQ QQQ L
Sbjct: 439 QQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQ 498
Query: 521 HSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTS 580
+ Q Q QQ Q+ L Q Q Q Q+ P SP++ SP TS
Sbjct: 499 QQINQ------------QQLQQQLQQRLQLQQLQHMQHQSQP----SPRQHSPVASQITS 542
Query: 581 SLPA 584
+PA
Sbjct: 543 PIPA 546
Score = 77.8 bits (190), Expect = 6e-14
Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 10/135 (7%)
Query: 440 QLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHH-----HH 494
Q QQ +LQQ Q + QQ QQQQ QQ Q QQ QQQ QQQ QHH H H
Sbjct: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496
Query: 495 LLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQ 554
L Q QQ Q Q QQ LQ Q L H +Q QPS Q+ + Q + Q
Sbjct: 497 LQQQINQQQLQQ--QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPI---PAIGSPQ 551
Query: 555 PSQQQASPEYLTSPQ 569
P+ QQ + + Q
Sbjct: 552 PASQQHQSQIQSQTQ 566
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 82.0 bits (201), Expect = 3e-15
Identities = 78/248 (31%), Positives = 109/248 (43%), Gaps = 15/248 (6%)
Query: 329 NNSSIPSALPEPMTASEAA--ARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSV 386
N+S A+ P+ ASE A R Q + ++ E P+Q+P+ P
Sbjct: 61 NSSPQRPAVSAPVGASEIAEETRPGQRELQLQQL----EQQPEPQQQPQHEQLQQPQPH- 115
Query: 387 LTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDW 446
L +Q + + + PE+ L Q PQQ + Q+LQQ
Sbjct: 116 LELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQE 175
Query: 447 RLQQLHLQHRHPHQQQQQQQQQQQQQQQ-QQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQ 505
+LQ Q + QQQ+Q QQQ Q+QQ QQQQ+Q QQQQ L Q + QQ +
Sbjct: 176 QLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQL--LQQQEQLQQQQFQQQQE 233
Query: 506 HATQQQQML---QQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASP 562
QQQQ+L QQ L + Q Q +Q + + QQA QQQ+L Q Q QQ
Sbjct: 234 QLQQQQQLLLLQQQGQLQQQLLQQQ--QAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQ 291
Query: 563 EYLTSPQE 570
+ L Q+
Sbjct: 292 QQLLQQQQ 299
Score = 73.2 bits (178), Expect = 1e-12
Identities = 59/148 (39%), Positives = 71/148 (47%), Gaps = 17/148 (11%)
Query: 430 QPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQ-----QQQQQQQQQQQQQQQQQQQ 484
Q Q+ +VLQQ +Q ++Q+ L + Q QQQQ +Q QQQQ QQQQ+Q QQQQ
Sbjct: 180 QQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQ 239
Query: 485 QQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFL--MHSVYQPQPSASQYPTMMPQYQQ 542
Q LLQ Q Q QQQ LQQQ L + Q Q Q + Q QQ
Sbjct: 240 QL-------LLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQ 292
Query: 543 AFFQQQMLAQHQPSQQQASPEYLTSPQE 570
QQQ Q Q QQQ P L +E
Sbjct: 293 QLLQQQ---QEQLQQQQLQPPPLEPEEE 317
Score = 57.0 bits (136), Expect = 1e-07
Identities = 53/148 (35%), Positives = 68/148 (45%), Gaps = 34/148 (22%)
Query: 425 QGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQ----QQQQQ 480
Q +Q QQ ++L QQG +LQQ LQ + QQQ +QQQ Q QQQ QQ+Q
Sbjct: 229 QQQQEQLQQQQQLLLLQQQG--QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQL 286
Query: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMP-- 538
QQQQQQ LLQ QQQ+ LQQQ L +P+ +MP
Sbjct: 287 QQQQQQ-------QLLQ-----------QQQEQLQQQQLQPPPLEPEEEEEVELELMPVD 328
Query: 539 --------QYQQAFFQQQMLAQHQPSQQ 558
Q +Q +QQ L + Q +Q
Sbjct: 329 LGSEQELEQQRQELERQQELERQQEQRQ 356
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/166 (33%), Positives = 75/166 (45%), Gaps = 17/166 (10%)
Query: 421 ILLGQGPPQQP---PQQHRVLQQL--QQGDWRLQQLHLQHRHPHQQQQQQQ--QQQQQQQ 473
+L QG QQ QQ ++ QQL QQ QQL LQ + QQQQQQQ QQQQ+Q
Sbjct: 243 LLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQL 302
Query: 474 QQQQQQQQQQQQQHHHHHHHHLL------QDAYMQQYQHATQQQQMLQQQFLMHSVYQPQ 527
QQQQ Q + + L+ + QQ Q +QQ++ +QQ + Q
Sbjct: 303 QQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQ 362
Query: 528 PSASQYPTMMPQYQQAFFQQQMLAQHQP----SQQQASPEYLTSPQ 569
Q + Q QQ QQ++ + P +QQQ LT Q
Sbjct: 363 EELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQ 408
>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
Length = 623
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/178 (35%), Positives = 78/178 (43%), Gaps = 13/178 (7%)
Query: 397 KVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHR 456
+V+ P + + L P +L Q QQ + + QQ LQ L Q +
Sbjct: 5 QVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQ 64
Query: 457 HPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQ 516
QQQQQQQQQQQQQQQQQQQQQQQQQQQ H QQ Q QQQQ+ Q
Sbjct: 65 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQ---QQQQLAAQ 121
Query: 517 QFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQ----QASPEYLTSPQE 570
Q + Q Q + Q Q+Q L P Q Q+ P+ SP E
Sbjct: 122 QLVF------QQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAE 173
>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
Length = 740
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/178 (35%), Positives = 78/178 (43%), Gaps = 13/178 (7%)
Query: 397 KVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHR 456
+V+ P + + L P +L Q QQ + + QQ LQ L Q +
Sbjct: 122 QVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQ 181
Query: 457 HPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQ 516
QQQQQQQQQQQQQQQQQQQQQQQQQQQ H QQ Q QQQQ+ Q
Sbjct: 182 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQ---QQQQLAAQ 238
Query: 517 QFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQ----QASPEYLTSPQE 570
Q + Q Q + Q Q+Q L P Q Q+ P+ SP E
Sbjct: 239 QLVF------QQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAE 290
Score = 32.0 bits (71), Expect = 3.5
Identities = 32/130 (24%), Positives = 46/130 (35%), Gaps = 25/130 (19%)
Query: 448 LQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQH------------------HH 489
++ LHLQ + Q +Q QQQ + + +Q+ H
Sbjct: 47 VELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQELLPETKLCICGHSSGDGHP 106
Query: 490 HHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQM 549
H+ + M Q T QQ QQ L V PQ Q ++ Q Q QQQ
Sbjct: 107 HNTFAVPVSVAMMTPQVITPQQM---QQILQQQVLSPQ----QLQALLQQQQAVMLQQQQ 159
Query: 550 LAQHQPSQQQ 559
L + QQ+
Sbjct: 160 LQEFYKKQQE 169
>gi|33286444 mastermind-like 2 [Homo sapiens]
Length = 1156
Score = 82.0 bits (201), Expect = 3e-15
Identities = 71/205 (34%), Positives = 84/205 (40%), Gaps = 16/205 (7%)
Query: 407 HRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466
+ P A+ P G L Q QQ + Q L Q + QQQQQQQ
Sbjct: 543 NNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQ 602
Query: 467 QQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAY--MQQYQHATQQQQMLQQQFLMHSVY 524
QQQQQQQQQQQQQQQQQQQ Q + QQ Q QQQQ QQQ
Sbjct: 603 QQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQ 662
Query: 525 QPQPSASQYPTMMPQ--------YQQAFFQQQMLAQ------HQPSQQQASPEYLTSPQE 570
Q QPS+ ++ Q QQ QQM Q +Q SQQQ ++ Q
Sbjct: 663 QQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQN 722
Query: 571 FSPALVSYTSSLPAQVGTIMDSSYS 595
P+ S P M+S S
Sbjct: 723 TGPSPSPNPCSNPNTGSGYMNSQQS 747
Score = 70.5 bits (171), Expect = 9e-12
Identities = 77/246 (31%), Positives = 94/246 (38%), Gaps = 56/246 (22%)
Query: 425 QGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQ 484
Q QQ QQ + QQ QQ QQ Q QQQQQQQQQQQQQQQQQQQQQQQQ
Sbjct: 603 QQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQ 662
Query: 485 QQHHHHHHHHLL-------------QDAYMQQYQH---ATQQQQMLQQQFL-MHSVY--- 524
QQ L Q +QQ Q+ A Q+ QQQ HSV
Sbjct: 663 QQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQN 722
Query: 525 ---QPQPSASQYPT---------------------------MMPQYQQAFFQQQMLAQHQ 554
P P+ P +M Q QQ QQQMLA +
Sbjct: 723 TGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAE 782
Query: 555 --PSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQ 612
Q Q + P ++ + + P T S S+ S+ +A+AN +
Sbjct: 783 KIAPQDQINRHLSRPPPDYKDQRRNVGNMQP----TAQYSGGSSTISLNSNQALANPVST 838
Query: 613 KNISNP 618
I P
Sbjct: 839 HTILTP 844
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,408,193
Number of Sequences: 37866
Number of extensions: 2679396
Number of successful extensions: 57077
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 971
Number of HSP's successfully gapped in prelim test: 1045
Number of HSP's that attempted gapping in prelim test: 22021
Number of HSP's gapped (non-prelim): 15615
length of query: 1161
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1048
effective length of database: 13,968,660
effective search space: 14639155680
effective search space used: 14639155680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.