Search of human proteins with 38787904

Search of human proteins with 38787904

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]
         (662 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]          1355   0.0  
gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]          1332   0.0  
gi|148277037 AP2 associated kinase 1 [Homo sapiens]                   664   0.0  
gi|157384971 cyclin G associated kinase [Homo sapiens]                182   7e-46
gi|57165436 serine/threonine kinase 16 [Homo sapiens]                 108   1e-23
gi|83627721 NIMA-related kinase 5 [Homo sapiens]                      108   1e-23
gi|41872673 NIMA-related kinase 1 [Homo sapiens]                      104   2e-22
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]             96   8e-20
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]             96   8e-20
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]            96   1e-19
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]                92   1e-18
gi|19424132 NIMA-related kinase 7 [Homo sapiens]                       90   6e-18
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]            90   6e-18
gi|110347429 mediator complex subunit 12 [Homo sapiens]                90   8e-18
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]            89   2e-17
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]             89   2e-17
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    86   1e-16
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    86   1e-16
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    86   1e-16
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]       84   4e-16
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       84   4e-16
gi|4505373 NIMA-related kinase 2 [Homo sapiens]                        83   7e-16
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       83   9e-16
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   82   1e-15
gi|226246533 TOX high mobility group box family member 3 isoform...    82   1e-15
gi|226054295 TOX high mobility group box family member 3 isoform...    82   1e-15
gi|221139761 zinc finger protein 853 [Homo sapiens]                    82   2e-15
gi|22538413 forkhead box P2 isoform III [Homo sapiens]                 82   2e-15
gi|149999352 forkhead box P2 isoform II [Homo sapiens]                 82   2e-15
gi|33286444 mastermind-like 2 [Homo sapiens]                           82   2e-15

>gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]
          Length = 662

 Score = 1355 bits (3507), Expect = 0.0
 Identities = 662/662 (100%), Positives = 662/662 (100%)

Query: 1   MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
           MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
Sbjct: 1   MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60

Query: 61  GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
           GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
Sbjct: 61  GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120

Query: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180
           DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
Sbjct: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180

Query: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240
           LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
Sbjct: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240

Query: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300
           KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
Sbjct: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300

Query: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360
           DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
Sbjct: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360

Query: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420
           IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
Sbjct: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420

Query: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480
           ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
Sbjct: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480

Query: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540
           QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
Sbjct: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540

Query: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600
           QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
Sbjct: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600

Query: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSSKGHLKAYFA 660
           ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSSKGHLKAYFA
Sbjct: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSSKGHLKAYFA 660

Query: 661 SQ 662
           SQ
Sbjct: 661 SQ 662


>gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]
          Length = 1161

 Score = 1332 bits (3448), Expect = 0.0
 Identities = 650/652 (99%), Positives = 652/652 (100%)

Query: 1   MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
           MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
Sbjct: 1   MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60

Query: 61  GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
           GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
Sbjct: 61  GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120

Query: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180
           DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
Sbjct: 121 DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD 180

Query: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240
           LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
Sbjct: 181 LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240

Query: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300
           KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
Sbjct: 241 KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP 300

Query: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360
           DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
Sbjct: 301 DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT 360

Query: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420
           IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
Sbjct: 361 IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE 420

Query: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480
           ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
Sbjct: 421 ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480

Query: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540
           QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
Sbjct: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY 540

Query: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600
           QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
Sbjct: 541 QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV 600

Query: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSSK 652
           ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRS++
Sbjct: 601 ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNR 652


>gi|148277037 AP2 associated kinase 1 [Homo sapiens]
          Length = 961

 Score =  664 bits (1713), Expect = 0.0
 Identities = 383/735 (52%), Positives = 458/735 (62%), Gaps = 95/735 (12%)

Query: 1   MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
           MKKF    + +GGSG G+   G GG+ +G G G  G     RVF +GR QVT++E LAEG
Sbjct: 1   MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIG-----RVFGIGRQQVTVDEVLAEG 55

Query: 61  GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
           GF+ VFLVRT  G++CALKRM+VNN  DL VCKREI IM++LSGHKNIVGY+D ++N++S
Sbjct: 56  GFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVS 115

Query: 121 D-NVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHR 179
             +VWEVLILM++CR GQVVN MN++LQTGFTE EVLQIFCDTCEAVARLHQCKTPIIHR
Sbjct: 116 SGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHR 175

Query: 180 DLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYG 239
           DLKVENILL+D G+YVLCDFGSATNKF NPQ +GVN VE+EIKKYTTLSYRAPEM+NLY 
Sbjct: 176 DLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS 235

Query: 240 GKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLE 299
           GK ITTKADIWALGCLLYKLC+FTLPFGESQVAICDGNFTIPDNSRYS+++HCLIR+MLE
Sbjct: 236 GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLE 295

Query: 300 PDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITD 359
           PDP+ RPDI+QVSYF+FK  KK+CP+ N+ NS IP+ LPEP+ ASEAAA+K+Q KAR+TD
Sbjct: 296 PDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTD 355

Query: 360 TIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----PGEFGNHRPKGALRP 415
            I  TETSIAPRQRPKA   T   P +L IQ + TP K       P   G+    G L  
Sbjct: 356 PIPTTETSIAPRQRPKAGQ-TQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLAS 414

Query: 416 GNGPEILLGQGPPQQP--------PQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ---QQ 464
              P+    Q PP QP        PQ     QQ      +      Q    HQQQ   +Q
Sbjct: 415 VPQPK---PQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQ 471

Query: 465 QQQQQQQQQQQQQ------QQQQQQQQQHHHHH-------------------HHHLLQDA 499
           QQQQQQ    QQQ      QQQQ Q QQ    H                      L+Q+ 
Sbjct: 472 QQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF 531

Query: 500 YMQQYQHATQQQQM-----------------LQQQFLMHSVYQPQPSASQYPTMMPQYQQ 542
           Y QQ Q   QQQQ                  LQQ+  M +  QPQP  +  P   P  + 
Sbjct: 532 YQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEP 591

Query: 543 AFFQQQMLAQHQPSQQQASPEY--------LTSPQE-----------FSPALVSYTSSLP 583
           A    Q   + QP  Q   P          LT P              S    S    +P
Sbjct: 592 AI---QAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVP 648

Query: 584 AQVGTIM------DSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTE 637
           A   T +      ++S + ++S     + +  T+Q+N+ NP + S WNPF +DNFSKLT 
Sbjct: 649 ASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTA 708

Query: 638 EELLDREFDLLRSSK 652
           EELL+++F  L   K
Sbjct: 709 EELLNKDFAKLGEGK 723


>gi|157384971 cyclin G associated kinase [Homo sapiens]
          Length = 1311

 Score =  182 bits (463), Expect = 7e-46
 Identities = 122/301 (40%), Positives = 163/301 (54%), Gaps = 15/301 (4%)

Query: 23  AGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHG-GIRCALKRM 81
           AG    G   G   S    +   +G  ++ +   LAEGGF+ V+  +  G G   ALKR+
Sbjct: 12  AGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL 71

Query: 82  YVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVW-----EVLILMEYCRAG 136
             N         +E+  MK+LSGH NIV +  C+  SI          E L+L E C+ G
Sbjct: 72  LSNEEEKNRAIIQEVCFMKKLSGHPNIVQF--CSAASIGKEESDTGQAEFLLLTELCK-G 128

Query: 137 QVVNQMNKKLQTG-FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV 195
           Q+V  + K    G  +   VL+IF  TC AV  +H+ K PIIHRDLKVEN+LL++ G   
Sbjct: 129 QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIK 188

Query: 196 LCDFGSATNKFLNP----QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWA 251
           LCDFGSAT     P          +VEEEI + TT  YR PE+I+LY   PI  K DIWA
Sbjct: 189 LCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWA 248

Query: 252 LGCLLYKLCFFTLPFGE-SQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQ 310
           LGC+LY LCF   PF + +++ I +G ++IP +       H LIR ML+ +PE R  I +
Sbjct: 249 LGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAE 308

Query: 311 V 311
           V
Sbjct: 309 V 309


>gi|57165436 serine/threonine kinase 16 [Homo sapiens]
          Length = 305

 Score =  108 bits (271), Expect = 1e-23
 Identities = 79/264 (29%), Positives = 124/264 (46%), Gaps = 14/264 (5%)

Query: 55  ESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLD 113
           + L EGGFS V LV   H G   ALKR+  +   D    +RE   M  L  H NI+  + 
Sbjct: 24  QKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREAD-MHRLFNHPNILRLVA 82

Query: 114 CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTG--FTEPEVLQIFCDTCEAVARLHQ 171
             +        E  +L+ + + G + N++ +    G   TE ++L +    C  +  +H 
Sbjct: 83  YCLRERGAK-HEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHA 141

Query: 172 CKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNV-VEEEIKKYTTLSYR 230
                 HRDLK  NILL D G  VL D GS     ++ +     + +++   +  T+SYR
Sbjct: 142 --KGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYR 199

Query: 231 APEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF------GESQVAICDGNFTIPDNS 284
           APE+ ++     I  + D+W+LGC+LY + F   P+      G+S         +IP + 
Sbjct: 200 APELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSP 259

Query: 285 RYSRNIHCLIRFMLEPDPEHRPDI 308
           R+S  +  L+  M+  DP  RP I
Sbjct: 260 RHSSALRQLLNSMMTVDPHQRPHI 283


>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
          Length = 708

 Score =  108 bits (271), Expect = 1e-23
 Identities = 79/263 (30%), Positives = 130/263 (49%), Gaps = 29/263 (11%)

Query: 55  ESLAEGGFSTVFLVRTHGGIR-CALKRMYVNNMP--DLNVCKREITIMKELSGHKNIVGY 111
           +++ +G F   +L +     + C +K +    MP  +    K+E+ +++++  H NIV +
Sbjct: 8   KAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK-HPNIVAF 66

Query: 112 LDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQ 171
                NS  +N   + I+MEYC  G ++ ++N++    F+E ++L  F      +  +H 
Sbjct: 67  F----NSFQEN-GRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121

Query: 172 CKTPIIHRDLKVENILLNDGGNYV-LCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYR 230
            K  I+HRD+K +NI L+  G    L DFG A  + LN      N +E       T  Y 
Sbjct: 122 RK--ILHRDIKAQNIFLSKNGMVAKLGDFGIA--RVLN------NSMELARTCIGTPYYL 171

Query: 231 APEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSR 285
           +PE+      KP   K DIW+LGC+LY+LC    PF  +      + IC  +F  P +  
Sbjct: 172 SPEICQ---NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFA-PISPG 227

Query: 286 YSRNIHCLIRFMLEPDPEHRPDI 308
           +SR +H LI  + +  P  RP I
Sbjct: 228 FSRELHSLISQLFQVSPRDRPSI 250


>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
          Length = 1258

 Score =  104 bits (260), Expect = 2e-22
 Identities = 79/262 (30%), Positives = 126/262 (48%), Gaps = 28/262 (10%)

Query: 55  ESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMP--DLNVCKREITIMKELSGHKNIVGY 111
           + + EG F    LV+ T  G +  +K + ++ M   +    +RE+ ++  +  H NIV Y
Sbjct: 8   QKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK-HPNIVQY 66

Query: 112 LDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQ 171
            +    S  +N   + I+M+YC  G +  ++N +    F E ++L  F   C A+  +H 
Sbjct: 67  RE----SFEEN-GSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHD 121

Query: 172 CKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRA 231
            K  I+HRD+K +NI L   G   L DFG A  + LN      + VE       T  Y +
Sbjct: 122 RK--ILHRDIKSQNIFLTKDGTVQLGDFGIA--RVLN------STVELARTCIGTPYYLS 171

Query: 232 PEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRY 286
           PE+      KP   K+DIWALGC+LY+LC     F         + I  G+F  P +  Y
Sbjct: 172 PEICE---NKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFP-PVSLHY 227

Query: 287 SRNIHCLIRFMLEPDPEHRPDI 308
           S ++  L+  + + +P  RP +
Sbjct: 228 SYDLRSLVSQLFKRNPRDRPSV 249


>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 85/333 (25%), Positives = 143/333 (42%), Gaps = 30/333 (9%)

Query: 57  LAEGGFSTVFLVRTHGGIRC-ALKRMYV-NNMPDLNVCKREITIMKELSGHKNIVGYLDC 114
           + EG F    LV+     +  A+K + +  +  +    ++E  ++ ++  H NIV + + 
Sbjct: 10  IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKES 68

Query: 115 AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKT 174
                 +    + I+MEYC  G ++ ++ ++    F E  +L  F   C  V  +H  K 
Sbjct: 69  F-----EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH--KK 121

Query: 175 PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEM 234
            ++HRD+K +NI L   G   L DFGSA     NP       V        T  Y  PE 
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPPE- 172

Query: 235 INLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRN 289
             ++   P   K+DIW+LGC+LY+LC    PF  +      + +C G  + P  S YS  
Sbjct: 173 --IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYSYE 229

Query: 290 IHCLIRFMLEPDPEHRPDIFQV--SYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAA 347
           +  L++ M + +P HRP    +       +  +K  P   I        L E   +    
Sbjct: 230 LQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYG-EEVLEEIKNSKHNT 288

Query: 348 ARKSQIKARITDTIGPTETSIAPRQRPKANSAT 380
            RK    +RI   +G   +++   ++ +  S T
Sbjct: 289 PRKKTNPSRIRIALGNEASTVQEEEQDRKGSHT 321


>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 85/333 (25%), Positives = 143/333 (42%), Gaps = 30/333 (9%)

Query: 57  LAEGGFSTVFLVRTHGGIRC-ALKRMYV-NNMPDLNVCKREITIMKELSGHKNIVGYLDC 114
           + EG F    LV+     +  A+K + +  +  +    ++E  ++ ++  H NIV + + 
Sbjct: 10  IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKES 68

Query: 115 AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKT 174
                 +    + I+MEYC  G ++ ++ ++    F E  +L  F   C  V  +H  K 
Sbjct: 69  F-----EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH--KK 121

Query: 175 PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEM 234
            ++HRD+K +NI L   G   L DFGSA     NP       V        T  Y  PE 
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPPE- 172

Query: 235 INLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRN 289
             ++   P   K+DIW+LGC+LY+LC    PF  +      + +C G  + P  S YS  
Sbjct: 173 --IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYSYE 229

Query: 290 IHCLIRFMLEPDPEHRPDIFQV--SYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAA 347
           +  L++ M + +P HRP    +       +  +K  P   I        L E   +    
Sbjct: 230 LQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYG-EEVLEEIKNSKHNT 288

Query: 348 ARKSQIKARITDTIGPTETSIAPRQRPKANSAT 380
            RK    +RI   +G   +++   ++ +  S T
Sbjct: 289 PRKKTNPSRIRIALGNEASTVQEEEQDRKGSHT 321


>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
          Length = 489

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 73/257 (28%), Positives = 119/257 (46%), Gaps = 27/257 (10%)

Query: 57  LAEGGFSTVFLVRTHGGIRC-ALKRMYV-NNMPDLNVCKREITIMKELSGHKNIVGYLDC 114
           + EG F    LV+     +  A+K + +  +  +    ++E  ++ ++  H NIV + + 
Sbjct: 10  IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKES 68

Query: 115 AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKT 174
                 +    + I+MEYC  G ++ ++ ++    F E  +L  F   C  V  +H  K 
Sbjct: 69  F-----EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH--KK 121

Query: 175 PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEM 234
            ++HRD+K +NI L   G   L DFGSA     NP       V        T  Y  PE 
Sbjct: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPPE- 172

Query: 235 INLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRN 289
             ++   P   K+DIW+LGC+LY+LC    PF  +      + +C G  + P  S YS  
Sbjct: 173 --IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYSYE 229

Query: 290 IHCLIRFMLEPDPEHRP 306
           +  L++ M + +P HRP
Sbjct: 230 LQFLVKQMFKRNPSHRP 246


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 96/387 (24%), Positives = 177/387 (45%), Gaps = 44/387 (11%)

Query: 48  RHQVTLEESLAEGGFSTVFLVRTHGGIRC----ALKRMYVNNMPDLNVCKREITIMKELS 103
           +H+  L+E+L +G +  V         R     ++++  + +  D+   +REI IM  L+
Sbjct: 52  KHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLN 111

Query: 104 GHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTC 163
            H +I+     ++  + +N  +++I+MEY   G++ + ++++ +   +E E    F    
Sbjct: 112 -HPHII-----SIYEVFENKDKIVIIMEYASKGELYDYISERRR--LSERETRHFFRQIV 163

Query: 164 EAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKK 223
            AV   H  K  ++HRDLK+ENILL+D  N  + DFG  +N +   QKD      + ++ 
Sbjct: 164 SAVHYCH--KNGVVHRDLKLENILLDDNCNIKIADFG-LSNLY---QKD------KFLQT 211

Query: 224 YT-TLSYRAPEMINLYGGKPIT-TKADIWALGCLLYKLCFFTLPFGESQ-----VAICDG 276
           +  +  Y +PE++N   G+P    + D WALG LLY L + T+PF           I  G
Sbjct: 212 FCGSPLYASPEIVN---GRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSG 268

Query: 277 NFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVS---YFAFKFAKKDCPVSNINNSSI 333
            +  P     +R    LIR+ML  +P+ R  I  ++   +  + +    C    +++S  
Sbjct: 269 EYREPTQPSDARG---LIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSES 325

Query: 334 PSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSA 393
           P           +   ++  +A++     PT TS    +R ++   +            A
Sbjct: 326 PLLARIIDWHHRSTGLQADTEAKMKGLAKPT-TSEVMLERQRSLKKSKKENDFAQSGQDA 384

Query: 394 TPVKVLAPGEFGNHRPKGALRPGNGPE 420
            P    +P +  + RPKG L+  +  E
Sbjct: 385 VPE---SPSKLSSKRPKGILKKRSNSE 408


>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
          Length = 302

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 76/274 (27%), Positives = 129/274 (47%), Gaps = 36/274 (13%)

Query: 53  LEESLAEGGFSTVFLVRTH-GGIRCALKRMYVNNMPDLNV---CKREITIMKELSGHKNI 108
           +E+ +  G FS V+       G+  ALK++ + ++ D      C +EI ++K+L+ H N+
Sbjct: 36  IEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN-HPNV 94

Query: 109 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMN--KKLQTGFTEPEVLQIFCDTCEAV 166
           + Y     + I DN  E+ I++E   AG +   +   KK +    E  V + F   C A+
Sbjct: 95  IKYY---ASFIEDN--ELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149

Query: 167 ARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 226
             +H  +  ++HRD+K  N+ +   G   L D G    +F + +    + +        T
Sbjct: 150 EHMHSRR--VMHRDIKPANVFITATGVVKLGDLG--LGRFFSSKTTAAHSL------VGT 199

Query: 227 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GE--------SQVAICDGN 277
             Y +PE I+  G      K+DIW+LGCLLY++     PF G+         ++  CD  
Sbjct: 200 PYYMSPERIHENG---YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCD-- 254

Query: 278 FTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 311
           +    +  YS  +  L+   + PDPE RPD+  V
Sbjct: 255 YPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 72/227 (31%), Positives = 113/227 (49%), Gaps = 34/227 (14%)

Query: 48  RHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMY---VNNMPDLNVCKREITIMKELSG 104
           RH+    E+L +G +  V   R   G   A+K +    + +  DL   +REI IM  L+ 
Sbjct: 50  RHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLN- 108

Query: 105 HKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCE 164
           H +I+     A++ + +N  +++I+MEY   G + + ++++ Q   +E E    F     
Sbjct: 109 HPHII-----AIHEVFENSSKIVIVMEYASRGDLYDYISERQQ--LSEREARHFFRQIVS 161

Query: 165 AVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSAT----NKFLNPQKDGVNVVEEE 220
           AV   HQ +  ++HRDLK+ENILL+  GN  + DFG +      KFL             
Sbjct: 162 AVHYCHQNR--VVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQ------------ 207

Query: 221 IKKYTTLSYRAPEMINLYGGKPIT-TKADIWALGCLLYKLCFFTLPF 266
                +  Y +PE++N   GKP T  + D W+LG LLY L   T+PF
Sbjct: 208 -TFCGSPLYASPEIVN---GKPYTGPEVDSWSLGVLLYILVHGTMPF 250


>gi|110347429 mediator complex subunit 12 [Homo sapiens]
          Length = 2177

 Score = 89.7 bits (221), Expect = 8e-18
 Identities = 52/105 (49%), Positives = 57/105 (54%), Gaps = 1/105 (0%)

Query: 458  PHQQQQQQQQQQQQQQQQQQQQQQQQQQQH-HHHHHHHLLQDAYMQQYQHATQQQQMLQQ 516
            P QQQQQQQQQQQQQQQQQQQQQQQQQQ H        +L+    QQ Q   QQQQ  QQ
Sbjct: 2049 PEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQ 2108

Query: 517  QFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQAS 561
            Q      +Q Q      P       Q  FQ+Q L Q Q  QQ A+
Sbjct: 2109 QQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAA 2153



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 59/129 (45%), Positives = 67/129 (51%), Gaps = 21/129 (16%)

Query: 421  ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQ---QQQQQQQQQQQQQQQQQ 477
            IL  Q   QQ  QQ +  QQ QQ   + QQ H++ +   Q   QQQQQQQQQQQQQQQQQ
Sbjct: 2047 ILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQ 2106

Query: 478  QQQQQQQQQHHHHHHHHLL--------QDAYMQQYQHATQQQQ-------MLQQQFLMHS 522
            QQQQQQQQQH                 Q  + +Q    TQQQQ        LQQQ    S
Sbjct: 2107 QQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQL---S 2163

Query: 523  VYQPQPSAS 531
              QPQPS +
Sbjct: 2164 NTQPQPSTN 2172



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 64/145 (44%), Positives = 69/145 (47%), Gaps = 28/145 (19%)

Query: 428  PQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQ--QQQQQQQQQQQQQQQQQQQQ 485
            P+Q  QQ +  QQ QQ   + QQ   Q  H  QQQQQQ  +QQQQQQQQQQQQQQQQQQQ
Sbjct: 2049 PEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQ 2108

Query: 486  QHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQ-YQQAF 544
            Q               QQ QH  QQQQ             PQP     P    Q  QQ  
Sbjct: 2109 QQ-------------QQQQQHQQQQQQ---------QAAPPQPQPQSQPQFQRQGLQQTQ 2146

Query: 545  FQQQMLAQHQPSQQQASPEYLTSPQ 569
             QQQ  A  +  QQQ S    T PQ
Sbjct: 2147 QQQQTAALVRQLQQQLSN---TQPQ 2168



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 42/110 (38%), Positives = 51/110 (46%), Gaps = 10/110 (9%)

Query: 473  QQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQ 532
            +QQQQQQQQQQQQQ          Q  Y  + Q   QQQQ+L+QQ       Q Q    Q
Sbjct: 2050 EQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQ---QQQQILRQQQQQQQQQQQQQQQQQ 2106

Query: 533  YPTMMPQYQQAFFQQQMLAQHQPSQQQASPEY------LTSPQEFSPALV 576
                  Q Q    QQQ  A  QP Q Q+ P++       T  Q+ + ALV
Sbjct: 2107 QQQQQQQQQHQQQQQQQAAPPQP-QPQSQPQFQRQGLQQTQQQQQTAALV 2155



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 46/185 (24%), Positives = 60/185 (32%), Gaps = 11/185 (5%)

Query: 389  IQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRL 448
            +Q    P   + P  + + +P  +  P   P ++         P +H  LQQ   G    
Sbjct: 1953 LQQHTGPAGTMVPPSYSS-QPYQSTHPSTNPTLV--------DPTRH--LQQRPSGYVHQ 2001

Query: 449  QQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHAT 508
            Q     H     Q+   Q  QQ            Q  Q        L +    QQ Q   
Sbjct: 2002 QAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQ 2061

Query: 509  QQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSP 568
            QQQQ  QQQ      Y  +    Q      Q QQ   QQQ   Q Q  QQQ         
Sbjct: 2062 QQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQ 2121

Query: 569  QEFSP 573
            Q+ +P
Sbjct: 2122 QQAAP 2126



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 38/153 (24%), Positives = 52/153 (33%), Gaps = 14/153 (9%)

Query: 459  HQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHH-----HHHHLLQDAYMQQYQHATQQQQM 513
            ++QQQ    Q Q+ +QQ QQ Q    Q   H       +       Y     H   QQ  
Sbjct: 1898 YRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHT 1957

Query: 514  LQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPS--QQQASPEY---LTSP 568
                 ++   Y  QP  S +P+  P             Q +PS    Q +P Y   LTS 
Sbjct: 1958 GPAGTMVPPSYSSQPYQSTHPSTNP----TLVDPTRHLQQRPSGYVHQQAPTYGHGLTST 2013

Query: 569  QEFSPALVSYTSSLPAQVGTIMDSSYSANRSVA 601
            Q FS   +  T  +            +  RS A
Sbjct: 2014 QRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTA 2046


>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
          Length = 347

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 79/276 (28%), Positives = 128/276 (46%), Gaps = 32/276 (11%)

Query: 53  LEESLAEGGFSTVFLVRTHGGIRC-ALKRMYVNNMPDLNV---CKREITIMKELSGHKNI 108
           +E+ +  G FS V+        +  ALK++ +  M D      C +EI ++K+L+ H NI
Sbjct: 81  IEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPNI 139

Query: 109 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMN--KKLQTGFTEPEVLQIFCDTCEAV 166
           + YLD   + I DN  E+ I++E   AG +   +   KK +    E  V + F   C AV
Sbjct: 140 IKYLD---SFIEDN--ELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 194

Query: 167 ARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 226
             +H  +  ++HRD+K  N+ +   G   L D G    +F + +    + +        T
Sbjct: 195 EHMHSRR--VMHRDIKPANVFITATGVVKLGDLG--LGRFFSSETTAAHSL------VGT 244

Query: 227 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQV---AICDG----NFT 279
             Y +PE I+  G      K+DIW+LGCLLY++     PF   ++   ++C      ++ 
Sbjct: 245 PYYMSPERIHENG---YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYP 301

Query: 280 IPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFA 315
                 YS  +  L+   + PDP  RPDI  V   A
Sbjct: 302 PLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVA 337


>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
          Length = 313

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 79/276 (28%), Positives = 128/276 (46%), Gaps = 32/276 (11%)

Query: 53  LEESLAEGGFSTVFLVRTHGGIRC-ALKRMYVNNMPDLNV---CKREITIMKELSGHKNI 108
           +E+ +  G FS V+        +  ALK++ +  M D      C +EI ++K+L+ H NI
Sbjct: 47  IEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPNI 105

Query: 109 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMN--KKLQTGFTEPEVLQIFCDTCEAV 166
           + YLD   + I DN  E+ I++E   AG +   +   KK +    E  V + F   C AV
Sbjct: 106 IKYLD---SFIEDN--ELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 160

Query: 167 ARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 226
             +H  +  ++HRD+K  N+ +   G   L D G    +F + +    + +        T
Sbjct: 161 EHMHSRR--VMHRDIKPANVFITATGVVKLGDLG--LGRFFSSETTAAHSL------VGT 210

Query: 227 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQV---AICDG----NFT 279
             Y +PE I+  G      K+DIW+LGCLLY++     PF   ++   ++C      ++ 
Sbjct: 211 PYYMSPERIHENG---YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYP 267

Query: 280 IPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFA 315
                 YS  +  L+   + PDP  RPDI  V   A
Sbjct: 268 PLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVA 303


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 119/559 (21%), Positives = 222/559 (39%), Gaps = 94/559 (16%)

Query: 53  LEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGY 111
           L E +  G +  V+  R    G   A+K M V    +  + K EI ++K+ S H+NI  Y
Sbjct: 27  LVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KLEINMLKKYSHHRNIATY 85

Query: 112 LDCAVNSI----SDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 167
               +        D +W   ++ME+C AG + + +         E  +  I  +    +A
Sbjct: 86  YGAFIKKSPPGHDDQLW---LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 142

Query: 168 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 227
            LH     +IHRD+K +N+LL +     L DFG      ++ Q D    V        T 
Sbjct: 143 HLHIHH--VIHRDIKGQNVLLTENAEVKLVDFG------VSAQLD--RTVGRRNTFIGTP 192

Query: 228 SYRAPEMINLYGGKPITT--KADIWALGCLLYKLCFFTLPFGESQVAICDGN-----FTI 280
            + APE+I        T   ++D+W+ G    ++        E    +CD +     F I
Sbjct: 193 YWMAPEVIACDENPDATYDYRSDLWSCGITAIEMA-------EGAPPLCDMHPMRALFLI 245

Query: 281 PDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSN-INNSSIPSALPE 339
           P N                P P  +   +   +F+F    + C V N +   S    L  
Sbjct: 246 PRN----------------PPPRLKSKKWSKKFFSFI---EGCLVKNYMQRPSTEQLLKH 286

Query: 340 PMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVL 399
           P    +   R  Q++ ++ D I  T      +   +   + +        +    P  ++
Sbjct: 287 PFIRDQPNER--QVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIV 344

Query: 400 -APGEFGNHRPKGALRPGNGP--------EILLGQGPPQQPPQQHRVLQQLQQGDWRLQQ 450
             PGE    R    L+  N          ++L  Q   +Q   + ++L + Q+   R++Q
Sbjct: 345 NVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQK---RIEQ 401

Query: 451 LHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQ----------------------QQQQQHH 488
              Q R   +QQ+++++ ++QQ+++Q++++Q                      +++++  
Sbjct: 402 QKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461

Query: 489 HHHHHHLLQDAYMQQYQHATQQQQMLQQQ-FLMHSVYQPQPSASQYPTMMPQYQQ---AF 544
                ++ +    +Q      QQQ+LQ+Q  L+H   +P P  SQ P   PQ ++   +F
Sbjct: 462 EREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPP-PPQQERSKPSF 520

Query: 545 FQQQMLAQHQPSQQQASPE 563
              +  A ++P+ +    E
Sbjct: 521 HAPEPKAHYEPADRAREVE 539


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 124/578 (21%), Positives = 229/578 (39%), Gaps = 96/578 (16%)

Query: 53  LEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGY 111
           L E +  G +  V+  R    G   A+K M V    +  + K EI ++K+ S H+NI  Y
Sbjct: 27  LVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KLEINMLKKYSHHRNIATY 85

Query: 112 LDCAVNSI----SDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 167
               +        D +W   ++ME+C AG + + +         E  +  I  +    +A
Sbjct: 86  YGAFIKKSPPGHDDQLW---LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 142

Query: 168 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 227
            LH     +IHRD+K +N+LL +     L DFG      ++ Q D    V        T 
Sbjct: 143 HLHIHH--VIHRDIKGQNVLLTENAEVKLVDFG------VSAQLD--RTVGRRNTFIGTP 192

Query: 228 SYRAPEMINLYGGKPITT--KADIWALGCLLYKLCFFTLPFGESQVAICDGN-----FTI 280
            + APE+I        T   ++D+W+ G    ++        E    +CD +     F I
Sbjct: 193 YWMAPEVIACDENPDATYDYRSDLWSCGITAIEMA-------EGAPPLCDMHPMRALFLI 245

Query: 281 PDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSN-INNSSIPSALPE 339
           P N                P P  +   +   +F+F    + C V N +   S    L  
Sbjct: 246 PRN----------------PPPRLKSKKWSKKFFSFI---EGCLVKNYMQRPSTEQLLKH 286

Query: 340 PMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVL 399
           P    +   R  Q++ ++ D I  T      +   +   + +        +    P  ++
Sbjct: 287 PFIRDQPNER--QVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIV 344

Query: 400 -APGEFGNHRPKGALRPGNGP--------EILLGQGPPQQPPQQHRVLQQLQQGDWRLQQ 450
             PGE    R    L+  N          ++L  Q   +Q   + ++L + Q+   R++Q
Sbjct: 345 NVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQK---RIEQ 401

Query: 451 LHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQ----------------------QQQQQHH 488
              Q R   +QQ+++++ ++QQ+++Q++++Q                      +++++  
Sbjct: 402 QKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461

Query: 489 HHHHHHLLQDAYMQQYQHATQQQQMLQQQ-FLMHSVYQPQPSASQYPTMMPQYQQ---AF 544
                ++ +    +Q      QQQ+LQ+Q  L+H   +P P  SQ P   PQ ++   +F
Sbjct: 462 EREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPP-PPQQERSKPSF 520

Query: 545 FQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSL 582
              +  A ++P+ +       T+ +  SP L    S L
Sbjct: 521 HAPEPKAHYEPADRAREVPVRTTSR--SPVLSRRDSPL 556


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 75/234 (32%), Positives = 98/234 (41%), Gaps = 33/234 (14%)

Query: 361  IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFG--------------- 405
            +GP + ++  +Q P A         VL  QS       LA    G               
Sbjct: 3802 LGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQ 3861

Query: 406  -NHRPKGALRPGNGPE--ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ 462
              H+ +G++   +  +  ++   G P+   Q    LQQLQQ     QQ  LQ +   Q Q
Sbjct: 3862 QQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQ 3921

Query: 463  QQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHS 522
            QQQQ QQQQ QQQQQQQQ QQQQQ               QQ Q   QQQQ  QQQF    
Sbjct: 3922 QQQQLQQQQLQQQQQQQQLQQQQQQQ-----------LQQQQQQLQQQQQQQQQQFQQQQ 3970

Query: 523  VYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALV 576
              Q     +Q  T++   QQ   QQQ +A   P       ++ +SP    P L+
Sbjct: 3971 QQQQMGLLNQSRTLLSPQQQ---QQQQVAL-GPGMPAKPLQHFSSPGALGPTLL 4020



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 71/231 (30%), Positives = 88/231 (38%), Gaps = 37/231 (16%)

Query: 367  SIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHR--PKGALRPGNGPEILLG 424
            +++P Q P+     T  P  L       P +    G+ G  R  P G   PG      L 
Sbjct: 3618 ALSPSQSPRL---LTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMALPGQPGGPFLN 3674

Query: 425  QGPPQQPPQQHR--------VLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQ 476
                QQ  QQH                G+  L+ L    R   ++Q Q QQQ+ Q  Q+ 
Sbjct: 3675 TALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKL 3734

Query: 477  QQQQQQQQQQHHHHHHHHLLQDAYMQQYQH---ATQQQQML--QQQFLMHS-------VY 524
            QQQQQQQQQQ       HLL    +QQ Q      Q  Q L  + Q LM         V 
Sbjct: 3735 QQQQQQQQQQ------QHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQ 3788

Query: 525  QPQPSASQYPT-MMPQYQQAFFQQQ---MLAQHQPSQQ--QASPEYLTSPQ 569
            Q  P   Q P  M+   Q A  QQQ    L    P +Q        L+SPQ
Sbjct: 3789 QLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQ 3839



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 48/156 (30%), Positives = 70/156 (44%), Gaps = 12/156 (7%)

Query: 459  HQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQF 518
            H++++ Q++QQ   Q Q  QQQQQQQQQH         Q A    ++ ++      QQQ 
Sbjct: 3255 HEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQ-AMSLPHEGSSPSLAGSQQQL 3313

Query: 519  LMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPE-YLTSPQEFSPA-LV 576
             +      QP   Q   +MP    A   QQ LA   PS    S + ++ S Q    A LV
Sbjct: 3314 SLGLAGARQPGLPQ--PLMPTQPPAHALQQRLA---PSMAMVSNQGHMLSGQHGGQAGLV 3368

Query: 577  SYTSSLPA----QVGTIMDSSYSANRSVADKEAIAN 608
               SS P      +GT+  S     + +A ++ +AN
Sbjct: 3369 PQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLAN 3404



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 20/44 (45%), Positives = 29/44 (65%), Gaps = 5/44 (11%)

Query: 449  QQLHLQHRHPHQQQQQQQQ-----QQQQQQQQQQQQQQQQQQQH 487
            QQ  +Q +    ++QQ++      + + +QQQQQQQQQQQQQQH
Sbjct: 3570 QQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQH 3613



 Score = 37.0 bits (84), Expect = 0.058
 Identities = 19/46 (41%), Positives = 27/46 (58%)

Query: 437  VLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQ 482
            V +Q  +   +L Q+  Q +       + + +QQQQQQQQQQQQQQ
Sbjct: 3567 VTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQ 3612



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 23/45 (51%), Positives = 29/45 (64%), Gaps = 7/45 (15%)

Query: 433  QQHRVLQQLQQGDWRLQQ-----LHLQHRHPHQQQQQQQQQQQQQ 472
            QQ ++ +QL Q   R QQ     L  ++R+  QQQQQQQQQQQQQ
Sbjct: 3570 QQSKIQKQLDQV--RKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQ 3612



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 17/39 (43%), Positives = 22/39 (56%)

Query: 450  QLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHH 488
            Q  L      Q++      + + +QQQQQQQQQQQQQ H
Sbjct: 3575 QKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQH 3613



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 15/30 (50%), Positives = 20/30 (66%)

Query: 460  QQQQQQQQQQQQQQQQQQQQQQQQQQQHHH 489
            QQ++      + + +QQQQQQQQQQQQ  H
Sbjct: 3584 QQKEHTNLMAEYRNKQQQQQQQQQQQQQQH 3613



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 42/173 (24%), Positives = 73/173 (42%), Gaps = 16/173 (9%)

Query: 416  GNGPEILLGQGPPQQPPQQHRVLQQ--LQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQ 473
            G+G E     G P QP        Q  + + D R  +  L H     Q Q +  ++Q   
Sbjct: 3477 GSGQE--RSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGV 3534

Query: 474  QQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQY 533
             ++ ++    +Q+           +A  ++ +  T+QQ  +Q+Q     + Q +    ++
Sbjct: 3535 HRKSRKALCAKQRTAKKAGREF-PEADAEKLKLVTEQQSKIQKQ-----LDQVRKQQKEH 3588

Query: 534  PTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQV 586
              +M +Y+    QQQ   Q Q  QQQ S     SP + SP L+   + LP Q+
Sbjct: 3589 TNLMAEYRNK--QQQQQQQQQQQQQQHSAVLALSPSQ-SPRLL---TKLPGQL 3635



 Score = 33.5 bits (75), Expect = 0.64
 Identities = 38/112 (33%), Positives = 48/112 (42%), Gaps = 9/112 (8%)

Query: 382  ATPSV-LTIQSSATPVKVLAPGEFGNHRPK----GALRPGNGPEILLGQGPPQQP--PQQ 434
            A PSV L  Q  +    +L P +    RP     G   P  GP +  GQG P     P  
Sbjct: 4135 AQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTV 4194

Query: 435  HRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQ 486
             ++  QLQ    +  QL  +H  P QQQQ Q    Q+Q QQ Q  +Q    Q
Sbjct: 4195 GQLRAQLQGVLAKNPQL--RHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQ 4244



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 15/95 (15%)

Query: 468  QQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQ 527
            +QQ + Q+Q  Q ++QQ++H +      L   Y  + Q   QQQQ  QQQ   HS     
Sbjct: 3569 EQQSKIQKQLDQVRKQQKEHTN------LMAEYRNKQQQQQQQQQQQQQQ---HSAVLAL 3619

Query: 528  PSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASP 562
             S SQ P ++ +        Q+L  H     Q  P
Sbjct: 3620 -SPSQSPRLLTK-----LPGQLLPGHGLQPPQGPP 3648


>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
          Length = 788

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 76/225 (33%), Positives = 87/225 (38%), Gaps = 49/225 (21%)

Query: 411 GALRPGNGPEILLGQGPP----QQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466
           G+L     P  L GQ PP      P     V     Q   +LQQ+ LQ +   QQ QQQQ
Sbjct: 114 GSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQ 173

Query: 467 QQQQQQQQQQQQQ------------------------QQQQQQQHH----HHHHHHLLQD 498
           Q   QQQQQQQQQ                        QQQQQQQ H    HH +   +Q 
Sbjct: 174 QAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQ 233

Query: 499 AYMQ-----QYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQ- 552
              Q     Q Q   QQQQ  QQQ       Q QP   Q P   PQ   +    Q L Q 
Sbjct: 234 QQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQM 293

Query: 553 -----HQPSQQQASPEYLTS------PQEFSPALVSYTSSLPAQV 586
                HQP  Q   P    +      PQ  +  LVS   +LP Q+
Sbjct: 294 HHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQM 338



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 50/195 (25%), Positives = 65/195 (33%), Gaps = 41/195 (21%)

Query: 420 EILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLH-LQHRHPHQQQQQQQQQQQQQQQQQQQ 478
           + L  Q P QQPP Q       Q    +LQQ+H  QH  P  Q QQ    Q Q  Q   Q
Sbjct: 262 QALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQ 321

Query: 479 QQQQQQQQHHHHHHHHLLQ-------------------DAYMQQYQHATQQQQMLQQ--- 516
            Q Q            +L                       +QQ Q A Q  Q  Q    
Sbjct: 322 SQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAP 381

Query: 517 ----------QFLMH--SVYQPQPSASQYPTM------MPQYQQAFFQQQMLAQHQPSQQ 558
                     Q  MH  + + P  + S  P+        P  Q +     ML+   P QQ
Sbjct: 382 GVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQ 441

Query: 559 QASPEYLTSPQEFSP 573
             +P+ +  P + SP
Sbjct: 442 VQTPQSMPPPPQPSP 456



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 29/126 (23%), Positives = 51/126 (40%), Gaps = 14/126 (11%)

Query: 324 PVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTAT 383
           P++ ++ SS+P      M +S +  ++ Q    +     P+     P  +P +N ++   
Sbjct: 421 PMAQVSQSSLP------MLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA 474

Query: 384 PSVLTI------QSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRV 437
           PS  +       Q S +PV    P  F    P     P N   ++   G  Q   QQ+  
Sbjct: 475 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY-- 532

Query: 438 LQQLQQ 443
           L +L+Q
Sbjct: 533 LDKLKQ 538


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 76/225 (33%), Positives = 87/225 (38%), Gaps = 49/225 (21%)

Query: 411 GALRPGNGPEILLGQGPP----QQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466
           G+L     P  L GQ PP      P     V     Q   +LQQ+ LQ +   QQ QQQQ
Sbjct: 114 GSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQ 173

Query: 467 QQQQQQQQQQQQQ------------------------QQQQQQQHH----HHHHHHLLQD 498
           Q   QQQQQQQQQ                        QQQQQQQ H    HH +   +Q 
Sbjct: 174 QAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQ 233

Query: 499 AYMQ-----QYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQ- 552
              Q     Q Q   QQQQ  QQQ       Q QP   Q P   PQ   +    Q L Q 
Sbjct: 234 QQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQM 293

Query: 553 -----HQPSQQQASPEYLTS------PQEFSPALVSYTSSLPAQV 586
                HQP  Q   P    +      PQ  +  LVS   +LP Q+
Sbjct: 294 HHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQM 338



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 64/187 (34%), Positives = 80/187 (42%), Gaps = 36/187 (19%)

Query: 433 QQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQ--QQQQQQQQQQQQQQQQQQHHHH 490
           QQ + LQQ QQ    L +LH Q++   QQQQQQ Q+  Q Q QQQQQQQQQQQQQQ    
Sbjct: 205 QQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQAL 264

Query: 491 HHHHLLQDAYMQQYQHATQQ---QQMLQQQFLMHSVYQPQPS----ASQYPTMMPQYQQA 543
                +Q   MQQ Q    Q   QQ+ Q     H    PQP     A   P+ +P   Q 
Sbjct: 265 QAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQT 324

Query: 544 ----------------------FFQQQMLAQHQP-----SQQQASPEYLTSPQEFSPALV 576
                                 F +  M+ Q  P      QQQ + +   + Q  +P + 
Sbjct: 325 QPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ 384

Query: 577 SYTSSLP 583
              SSLP
Sbjct: 385 VSQSSLP 391


>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
          Length = 445

 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 71/228 (31%), Positives = 109/228 (47%), Gaps = 28/228 (12%)

Query: 95  EITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNK--KLQTGFTE 152
           E+ +++EL  H NIV Y D  ++  +  ++   I+MEYC  G + + + K  K +    E
Sbjct: 55  EVNLLRELK-HPNIVRYYDRIIDRTNTTLY---IVMEYCEGGDLASVITKGTKERQYLDE 110

Query: 153 PEVLQIFCDTCEAVARLHQCKT---PIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNP 209
             VL++      A+   H+       ++HRDLK  N+ L+   N  L DFG A  + LN 
Sbjct: 111 EFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLA--RILNH 168

Query: 210 QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLP---F 266
                           T  Y +PE +N         K+DIW+LGCLLY+LC    P   F
Sbjct: 169 DTSFAKTF------VGTPYYMSPEQMNRMS---YNEKSDIWSLGCLLYELCALMPPFTAF 219

Query: 267 GESQVA--ICDGNF-TIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 311
            + ++A  I +G F  IP   RYS  ++ +I  ML     HRP + ++
Sbjct: 220 SQKELAGKIREGKFRRIP--YRYSDELNEIITRMLNLKDYHRPSVEEI 265


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 71/242 (29%), Positives = 113/242 (46%), Gaps = 29/242 (11%)

Query: 78  LKRMYVNNMP--DLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRA 135
           +K++ V  M   +    + E  ++K L+ H N++ Y +   N + D    ++I MEY   
Sbjct: 32  IKQIPVEQMTKEERQAAQNECQVLKLLN-HPNVIEYYE---NFLEDKA--LMIAMEYAPG 85

Query: 136 GQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV 195
           G +   + K+  +   E  +L  F     A+  +H     I+HRDLK +NILL+     V
Sbjct: 86  GTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL--ILHRDLKTQNILLDKHRMVV 143

Query: 196 -LCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGC 254
            + DFG   +K L+ +     VV        T  Y +PE+     GKP   K+DIWALGC
Sbjct: 144 KIGDFG--ISKILSSKSKAYTVVG-------TPCYISPELCE---GKPYNQKSDIWALGC 191

Query: 255 LLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIF 309
           +LY+L      F  +      + I  G F  P + RYS  +  L+  +L  +P  RP + 
Sbjct: 192 VLYELASLKRAFEAANLPALVLKIMSGTFA-PISDRYSPELRQLVLSLLSLEPAQRPPLS 250

Query: 310 QV 311
            +
Sbjct: 251 HI 252


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 66/197 (33%), Positives = 84/197 (42%), Gaps = 13/197 (6%)

Query: 378 SATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRV 437
           S+    P  + +  +    +V+ P +      +  L P     +L  Q       QQ + 
Sbjct: 78  SSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQE 137

Query: 438 LQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQ 497
             + QQ    LQ L  Q +   QQQQQQQQQQQQQQQQQQQQQQQQQQQ     H     
Sbjct: 138 FYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQA 197

Query: 498 DAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQ 557
               QQ Q   QQQQ+  QQ +       Q    Q   +  Q      Q+Q L    P Q
Sbjct: 198 KEQQQQQQ---QQQQLAAQQLVF------QQQLLQMQQLQQQQHLLSLQRQGLISIPPGQ 248

Query: 558 Q----QASPEYLTSPQE 570
                Q+ P+   SP E
Sbjct: 249 AALPVQSLPQAGLSPAE 265



 Score = 37.0 bits (84), Expect = 0.058
 Identities = 49/170 (28%), Positives = 51/170 (30%), Gaps = 69/170 (40%)

Query: 459 HQQQQQ---------------------------------------------QQQQQQQQQ 473
           H QQQQ                                             QQ QQ  QQ
Sbjct: 51  HLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQ 110

Query: 474 Q-----------QQQQQQQQQQQQHHHHH-------HHHLLQDAYMQQYQHATQQQQMLQ 515
           Q           QQQQ    QQQQ    +       H  LLQ    QQ Q   QQQQ  Q
Sbjct: 111 QVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQ 170

Query: 516 QQFLMHSVYQPQPSASQYPTMMP------QYQQAFFQQQMLAQHQPSQQQ 559
           QQ       Q Q    Q     P      Q QQ   QQQ+ AQ    QQQ
Sbjct: 171 QQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQ 220


>gi|226246533 TOX high mobility group box family member 3 isoform 2
           [Homo sapiens]
          Length = 571

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 51/124 (41%), Positives = 59/124 (47%), Gaps = 16/124 (12%)

Query: 461 QQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLM 520
           QQ Q Q QQQQQQQQQQ QQ QQQQ   H  H  + Q    Q +QH  QQ    QQQ L 
Sbjct: 434 QQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQ 493

Query: 521 HSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTS 580
             + Q             Q QQ   Q+  L Q Q  Q Q+ P    SP++ SP     TS
Sbjct: 494 QQINQ------------QQLQQQLQQRLQLQQLQHMQHQSQP----SPRQHSPVASQITS 537

Query: 581 SLPA 584
            +PA
Sbjct: 538 PIPA 541



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 10/135 (7%)

Query: 440 QLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHH-----HH 494
           Q QQ   +LQQ   Q +   QQ QQQQ QQ Q  QQ QQQ QQQ  QHH   H      H
Sbjct: 432 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 491

Query: 495 LLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQ 554
           L Q    QQ Q   Q QQ LQ Q L H  +Q QPS  Q+  +  Q          +   Q
Sbjct: 492 LQQQINQQQLQQ--QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPI---PAIGSPQ 546

Query: 555 PSQQQASPEYLTSPQ 569
           P+ QQ   +  +  Q
Sbjct: 547 PASQQHQSQIQSQTQ 561


>gi|226054295 TOX high mobility group box family member 3 isoform 1
           [Homo sapiens]
          Length = 576

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 51/124 (41%), Positives = 59/124 (47%), Gaps = 16/124 (12%)

Query: 461 QQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLM 520
           QQ Q Q QQQQQQQQQQ QQ QQQQ   H  H  + Q    Q +QH  QQ    QQQ L 
Sbjct: 439 QQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQ 498

Query: 521 HSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTS 580
             + Q             Q QQ   Q+  L Q Q  Q Q+ P    SP++ SP     TS
Sbjct: 499 QQINQ------------QQLQQQLQQRLQLQQLQHMQHQSQP----SPRQHSPVASQITS 542

Query: 581 SLPA 584
            +PA
Sbjct: 543 PIPA 546



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 10/135 (7%)

Query: 440 QLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHH-----HH 494
           Q QQ   +LQQ   Q +   QQ QQQQ QQ Q  QQ QQQ QQQ  QHH   H      H
Sbjct: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496

Query: 495 LLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQ 554
           L Q    QQ Q   Q QQ LQ Q L H  +Q QPS  Q+  +  Q          +   Q
Sbjct: 497 LQQQINQQQLQQ--QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPI---PAIGSPQ 551

Query: 555 PSQQQASPEYLTSPQ 569
           P+ QQ   +  +  Q
Sbjct: 552 PASQQHQSQIQSQTQ 566


>gi|221139761 zinc finger protein 853 [Homo sapiens]
          Length = 659

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 78/248 (31%), Positives = 109/248 (43%), Gaps = 15/248 (6%)

Query: 329 NNSSIPSALPEPMTASEAA--ARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSV 386
           N+S    A+  P+ ASE A   R  Q + ++       E    P+Q+P+        P  
Sbjct: 61  NSSPQRPAVSAPVGASEIAEETRPGQRELQLQQL----EQQPEPQQQPQHEQLQQPQPH- 115

Query: 387 LTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDW 446
           L +Q            +    + +        PE+ L     Q  PQQ +  Q+LQQ   
Sbjct: 116 LELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQE 175

Query: 447 RLQQLHLQHRHPHQQQQQQQQQQQQQQQ-QQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQ 505
           +LQ    Q +   QQQ+Q QQQ Q+QQ  QQQQ+Q QQQQ         L Q  + QQ +
Sbjct: 176 QLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQL--LQQQEQLQQQQFQQQQE 233

Query: 506 HATQQQQML---QQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASP 562
              QQQQ+L   QQ  L   + Q Q   +Q    + + QQA  QQQ+L Q Q   QQ   
Sbjct: 234 QLQQQQQLLLLQQQGQLQQQLLQQQ--QAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQ 291

Query: 563 EYLTSPQE 570
           + L   Q+
Sbjct: 292 QQLLQQQQ 299



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 59/148 (39%), Positives = 71/148 (47%), Gaps = 17/148 (11%)

Query: 430 QPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQ-----QQQQQQQQQQQQQQQQQQQ 484
           Q  Q+ +VLQQ +Q   ++Q+  L  +   Q QQQQ     +Q QQQQ QQQQ+Q QQQQ
Sbjct: 180 QQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQ 239

Query: 485 QQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFL--MHSVYQPQPSASQYPTMMPQYQQ 542
           Q         LLQ     Q Q   QQQ  LQQQ L    +  Q Q    Q   +  Q QQ
Sbjct: 240 QL-------LLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQ 292

Query: 543 AFFQQQMLAQHQPSQQQASPEYLTSPQE 570
              QQQ   Q Q  QQQ  P  L   +E
Sbjct: 293 QLLQQQ---QEQLQQQQLQPPPLEPEEE 317



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 53/148 (35%), Positives = 68/148 (45%), Gaps = 34/148 (22%)

Query: 425 QGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQ----QQQQQ 480
           Q   +Q  QQ ++L   QQG  +LQQ  LQ +    QQQ  +QQQ Q QQQ    QQ+Q 
Sbjct: 229 QQQQEQLQQQQQLLLLQQQG--QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQL 286

Query: 481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMP-- 538
           QQQQQQ        LLQ           QQQ+ LQQQ L     +P+        +MP  
Sbjct: 287 QQQQQQ-------QLLQ-----------QQQEQLQQQQLQPPPLEPEEEEEVELELMPVD 328

Query: 539 --------QYQQAFFQQQMLAQHQPSQQ 558
                   Q +Q   +QQ L + Q  +Q
Sbjct: 329 LGSEQELEQQRQELERQQELERQQEQRQ 356



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 56/166 (33%), Positives = 75/166 (45%), Gaps = 17/166 (10%)

Query: 421 ILLGQGPPQQP---PQQHRVLQQL--QQGDWRLQQLHLQHRHPHQQQQQQQ--QQQQQQQ 473
           +L  QG  QQ     QQ ++ QQL  QQ     QQL LQ +   QQQQQQQ  QQQQ+Q 
Sbjct: 243 LLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQL 302

Query: 474 QQQQQQQQQQQQQHHHHHHHHLL------QDAYMQQYQHATQQQQMLQQQFLMHSVYQPQ 527
           QQQQ Q    + +        L+      +    QQ Q   +QQ++ +QQ       + Q
Sbjct: 303 QQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQ 362

Query: 528 PSASQYPTMMPQYQQAFFQQQMLAQHQP----SQQQASPEYLTSPQ 569
               Q    + Q QQ   QQ++  +  P    +QQQ     LT  Q
Sbjct: 363 EELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQ 408


>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
          Length = 623

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 64/178 (35%), Positives = 78/178 (43%), Gaps = 13/178 (7%)

Query: 397 KVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHR 456
           +V+ P +      +  L P     +L  Q       QQ +   + QQ    LQ L  Q +
Sbjct: 5   QVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQ 64

Query: 457 HPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQ 516
              QQQQQQQQQQQQQQQQQQQQQQQQQQQ     H         QQ Q   QQQQ+  Q
Sbjct: 65  QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQ---QQQQLAAQ 121

Query: 517 QFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQ----QASPEYLTSPQE 570
           Q +       Q    Q   +  Q      Q+Q L    P Q     Q+ P+   SP E
Sbjct: 122 QLVF------QQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAE 173


>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
          Length = 740

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 64/178 (35%), Positives = 78/178 (43%), Gaps = 13/178 (7%)

Query: 397 KVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHR 456
           +V+ P +      +  L P     +L  Q       QQ +   + QQ    LQ L  Q +
Sbjct: 122 QVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQ 181

Query: 457 HPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQ 516
              QQQQQQQQQQQQQQQQQQQQQQQQQQQ     H         QQ Q   QQQQ+  Q
Sbjct: 182 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQ---QQQQLAAQ 238

Query: 517 QFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQ----QASPEYLTSPQE 570
           Q +       Q    Q   +  Q      Q+Q L    P Q     Q+ P+   SP E
Sbjct: 239 QLVF------QQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAE 290



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 32/130 (24%), Positives = 46/130 (35%), Gaps = 25/130 (19%)

Query: 448 LQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQH------------------HH 489
           ++ LHLQ +   Q  +Q   QQQ    +  +   +Q+                     H 
Sbjct: 47  VELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQELLPETKLCICGHSSGDGHP 106

Query: 490 HHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQM 549
           H+   +     M   Q  T QQ    QQ L   V  PQ    Q   ++ Q Q    QQQ 
Sbjct: 107 HNTFAVPVSVAMMTPQVITPQQM---QQILQQQVLSPQ----QLQALLQQQQAVMLQQQQ 159

Query: 550 LAQHQPSQQQ 559
           L +    QQ+
Sbjct: 160 LQEFYKKQQE 169


>gi|33286444 mastermind-like 2 [Homo sapiens]
          Length = 1156

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 71/205 (34%), Positives = 84/205 (40%), Gaps = 16/205 (7%)

Query: 407 HRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466
           + P  A+ P  G    L      Q  QQ   +   Q     L     Q +   QQQQQQQ
Sbjct: 543 NNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQ 602

Query: 467 QQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAY--MQQYQHATQQQQMLQQQFLMHSVY 524
           QQQQQQQQQQQQQQQQQQQ           Q +    QQ Q   QQQQ  QQQ       
Sbjct: 603 QQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQ 662

Query: 525 QPQPSASQYPTMMPQ--------YQQAFFQQQMLAQ------HQPSQQQASPEYLTSPQE 570
           Q QPS+    ++  Q         QQ    QQM  Q      +Q SQQQ   ++    Q 
Sbjct: 663 QQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQN 722

Query: 571 FSPALVSYTSSLPAQVGTIMDSSYS 595
             P+      S P      M+S  S
Sbjct: 723 TGPSPSPNPCSNPNTGSGYMNSQQS 747



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 77/246 (31%), Positives = 94/246 (38%), Gaps = 56/246 (22%)

Query: 425 QGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQ 484
           Q   QQ  QQ +  QQ QQ     QQ   Q      QQQQQQQQQQQQQQQQQQQQQQQQ
Sbjct: 603 QQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQ 662

Query: 485 QQHHHHHHHHLL-------------QDAYMQQYQH---ATQQQQMLQQQFL-MHSVY--- 524
           QQ         L             Q   +QQ Q+   A    Q+ QQQ    HSV    
Sbjct: 663 QQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQN 722

Query: 525 ---QPQPSASQYPT---------------------------MMPQYQQAFFQQQMLAQHQ 554
               P P+    P                            +M Q QQ   QQQMLA  +
Sbjct: 723 TGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAE 782

Query: 555 --PSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQ 612
               Q Q +      P ++     +  +  P    T   S  S+  S+   +A+AN  + 
Sbjct: 783 KIAPQDQINRHLSRPPPDYKDQRRNVGNMQP----TAQYSGGSSTISLNSNQALANPVST 838

Query: 613 KNISNP 618
             I  P
Sbjct: 839 HTILTP 844


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.131    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,209,923
Number of Sequences: 37866
Number of extensions: 1492970
Number of successful extensions: 48933
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1022
Number of HSP's successfully gapped in prelim test: 662
Number of HSP's that attempted gapping in prelim test: 16881
Number of HSP's gapped (non-prelim): 12969
length of query: 662
length of database: 18,247,518
effective HSP length: 109
effective length of query: 553
effective length of database: 14,120,124
effective search space: 7808428572
effective search space used: 7808428572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.