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Search of human proteins with 38569419
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38569419 AAT1-alpha [Homo sapiens]
(767 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38569419 AAT1-alpha [Homo sapiens] 1516 0.0
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 55 2e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 54 7e-07
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 53 9e-07
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 52 2e-06
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 51 4e-06
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 50 6e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 50 6e-06
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 50 6e-06
gi|100814339 coiled-coil domain containing 146 [Homo sapiens] 50 1e-05
gi|156104874 envoplakin [Homo sapiens] 49 1e-05
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 49 1e-05
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 49 1e-05
gi|4758648 kinesin family member 5B [Homo sapiens] 49 2e-05
gi|45439327 periplakin [Homo sapiens] 48 3e-05
gi|222537714 taxilin beta [Homo sapiens] 48 4e-05
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 48 4e-05
gi|221219020 NYD-SP11 protein [Homo sapiens] 47 7e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 47 9e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 47 9e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 47 9e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 47 9e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 47 9e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 47 9e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 47 9e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 47 9e-05
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 47 9e-05
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 46 1e-04
gi|21735548 centrosomal protein 2 [Homo sapiens] 46 1e-04
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens] 46 1e-04
>gi|38569419 AAT1-alpha [Homo sapiens]
Length = 767
Score = 1516 bits (3926), Expect = 0.0
Identities = 767/767 (100%), Positives = 767/767 (100%)
Query: 1 MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKDHTQANIQA 60
MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKDHTQANIQA
Sbjct: 1 MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKDHTQANIQA 60
Query: 61 TLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISREWKGHKEKHREALRQLTT 120
TLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISREWKGHKEKHREALRQLTT
Sbjct: 61 TLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISREWKGHKEKHREALRQLTT 120
Query: 121 TDASFQMPKEVYEDPEVTGKNRYKYFERPFLPFFQQMPFNVVYAVSKAEPYTFPPTSTKH 180
TDASFQMPKEVYEDPEVTGKNRYKYFERPFLPFFQQMPFNVVYAVSKAEPYTFPPTSTKH
Sbjct: 121 TDASFQMPKEVYEDPEVTGKNRYKYFERPFLPFFQQMPFNVVYAVSKAEPYTFPPTSTKH 180
Query: 181 LSIPSKSTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEM 240
LSIPSKSTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEM
Sbjct: 181 LSIPSKSTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEM 240
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL
Sbjct: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
Query: 301 RKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNI 360
RKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNI
Sbjct: 301 RKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNI 360
Query: 361 IKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRA 420
IKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRA
Sbjct: 361 IKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRA 420
Query: 421 PKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTP 480
PKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTP
Sbjct: 421 PKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTP 480
Query: 481 TLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVK 540
TLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVK
Sbjct: 481 TLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVK 540
Query: 541 KAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFV 600
KAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFV
Sbjct: 541 KAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFV 600
Query: 601 MLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAE 660
MLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAE
Sbjct: 601 MLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAE 660
Query: 661 EQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQR 720
EQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQR
Sbjct: 661 EQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQR 720
Query: 721 KHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNENNS 767
KHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNENNS
Sbjct: 721 KHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNENNS 767
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 55.5 bits (132), Expect = 2e-07
Identities = 81/316 (25%), Positives = 136/316 (43%), Gaps = 49/316 (15%)
Query: 442 ELAEVHKALLDKKNKV-LEVKKPPRFLQRNPIPQPRLPTPTL--EMTSNEEE--EMEMAV 496
EL E + +K+++ L VK+ R L+R P++ T TL EM EEE E E +
Sbjct: 191 ELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKI 250
Query: 497 IYLQKLL-----RGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQ 551
++ + R R + M E +EK QE R L+E EK +++ EK+ L+
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRR--QEKR----LREQEKELREQEKE----LR 300
Query: 552 RQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
Q+ L E + + E E +E +R QEE+ L E+++++RE
Sbjct: 301 EQKKLREQEEQMQEQEEKMWE-----------QEEKMREQEEKMWRQEERLWEQEKQMRE 349
Query: 612 AEESGRRQVEK-----QRLREEDEIFKEVVKVHHSTISSYLEDIILNTEAN-TAEEQARA 665
E+ R Q E+ +RLRE++E +E K+ E+ I E EE+
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR 409
Query: 666 EIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILA 725
E E+ +K + +E E + Q +PE ++ +++ Q + I
Sbjct: 410 EQEEKMQKQEENMWEQEEKEWQQQR------------LPEQKEKLWEQEKMQEQEEKIWE 457
Query: 726 AHQIIHSYTESMVQKK 741
+ I E Q+K
Sbjct: 458 QEEKIRDQEEMWGQEK 473
Score = 43.1 bits (100), Expect = 0.001
Identities = 65/285 (22%), Positives = 124/285 (43%), Gaps = 22/285 (7%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVI 497
R + EL E K + ++ K+ ++ R + Q + +E+E+
Sbjct: 238 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEK 297
Query: 498 YLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHA-LQEDEKLVKKAEKQVTLALQRQRNL 556
L++ + R + M E +EK E +++R + E+ + + EKQ+ Q+ R+
Sbjct: 298 ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD- 356
Query: 557 HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESG 616
E ++ + L E R + +E ++QEE RI ER++++RE EE+
Sbjct: 357 QEERMWEQDERLREKEERMREQEKMWEQEE--KMQEEERIR------EREKKMREEEETM 408
Query: 617 RRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKIND 676
R Q EK + +EE+ +E + + E + + EE +I + EKI D
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE----KIWEQEEKIRD 464
Query: 677 IAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRK 721
EM + + +E + E E Q + +EK+R+ ++K
Sbjct: 465 -QEEMWGQEKKMWRQEKMRE-------QEDQMWEQEEKMRDQEQK 501
Score = 41.2 bits (95), Expect = 0.004
Identities = 53/249 (21%), Positives = 110/249 (44%), Gaps = 14/249 (5%)
Query: 445 EVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR 504
E + L +K+ ++ E KK + Q + + + + T ++EE+M ++ +
Sbjct: 511 EQDERLREKEERMREQKK--MWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 505 GRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLV 564
R + MM E +EK E +++R +++EK+ ++ EK +++ + E + +
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMR-----EQEEKMWEQEEKMQ----EQEEKMWEQEEKMW 619
Query: 565 ENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQR 624
E M++ +E ++ QEE+ + E++ ++RE EE + Q EK R
Sbjct: 620 EQEEEDKMQEQEEMMWE--QEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR 677
Query: 625 LREED-EIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMES 683
+EE + +E ++ + E + E +E+ E+M EK I + E
Sbjct: 678 EQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEK 737
Query: 684 RRTYLQSEE 692
+ L E
Sbjct: 738 MQERLPEHE 746
Score = 39.3 bits (90), Expect = 0.014
Identities = 91/479 (18%), Positives = 198/479 (41%), Gaps = 82/479 (17%)
Query: 262 QFEKRRKMMNEMERKEWAFREQE------IEKL--QEIRLEVLKELLRKREENQNEVNMK 313
Q +K RK +M R+E REQE EK+ QE RL ++ LR++E+ E K
Sbjct: 246 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE--QK 303
Query: 314 HLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYG 373
L + ++QE +E + ++ + + + E + + R + D +++
Sbjct: 304 KLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 363
Query: 374 PLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFL 433
RL K + E + E E + + + +IR + K+ +
Sbjct: 364 QDERLR-----------EKEERMREQEKMWEQEEKMQE---EERIREREKKMREEEETMR 409
Query: 434 KRAARLDYELAEVHKALLDKKNKVLEVKKPP----RFLQRNPIPQPRLPTPTLEMTSNEE 489
++ ++ + + + +++ K + ++ P + ++ + + E ++
Sbjct: 410 EQEEKMQKQ----EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Query: 490 EEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL--RTCHALQEDEKLVKKAEKQVT 547
EEM + + + R ++ M+E +EK + Q++ + ++DE+L +K E+
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER--- 522
Query: 548 LALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQR 607
++ Q+ + + + + E + + D + +++EE R+ ER++
Sbjct: 523 --MREQKKMWQQEEKMREEKKTQEQEKKTWDQEE-------KMREEERMR------EREK 567
Query: 608 RVREAEESGRRQVEK-----QRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQ 662
++RE EE R Q EK +++RE++E E EE+
Sbjct: 568 KMREEEEMMREQEEKMQEQEEKMREQEEKMWE------------------------QEEK 603
Query: 663 ARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRK 721
+ + EKM E+ + +E E + EE++ E E + + +EK+R + K
Sbjct: 604 MQEQEEKMWEQ-EEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK 661
Score = 38.1 bits (87), Expect = 0.031
Identities = 90/450 (20%), Positives = 180/450 (40%), Gaps = 68/450 (15%)
Query: 237 EVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVL 296
E E R +E+R WE + ++ KM + E+ + R +E EK E +
Sbjct: 349 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408
Query: 297 KEL---LRKREEN-----QNEVNMKHLNARWSKL--QEGKEAKMAKI--QRTHVSTIRKL 344
+E ++K+EEN + E + L + KL QE + + KI Q + ++
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 468
Query: 345 VGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
G+ K K+ R+ +++ D Q++ ++ D + + + E L E
Sbjct: 469 WGQEK----KMWRQEKMREQED---QMWEQEEKM---RDQEQKMWDQEERMWEQDERLRE 518
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPP 464
E ++R K K + R + + E K D++ K+ E ++
Sbjct: 519 KEE---------RMREQK------KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMR 563
Query: 465 RFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQ 524
++ + + +M EE+ E ++ + + + M+E +EK E +
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 525 ELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLS 584
E +QE E+++ + E+++ +++ + E + + E
Sbjct: 624 E----DKMQEQEEMMWEQEEKMQ---EQEEKMWEQEEKMRE------------------Q 658
Query: 585 KELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+E +R QEE+ + E++ +++ EE R Q EK R +EE +E +
Sbjct: 659 EEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQE------EKMW 712
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKI 674
E + E EE+ R + EKM E++
Sbjct: 713 GQEEKMWGQEEMREKEERIRDQKEKMQERL 742
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 53.5 bits (127), Expect = 7e-07
Identities = 73/294 (24%), Positives = 127/294 (43%), Gaps = 45/294 (15%)
Query: 452 DKKNKVLEVKKPPRFLQRNPIPQPRLPTPTL--EMTSNEEE--EMEMAVIYLQKLL---- 503
+K L VK+ R L+R P++ T TL EM EEE E E + ++ +
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 504 -RGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVS 562
R R + M E +EK QE R L+E EK +++ EK+ L+ Q+ L E +
Sbjct: 300 ERLREQEGKMREQEEKMWR--QEKR----LREQEKELREQEKE----LREQKELREQEEQ 349
Query: 563 LVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEK 622
+ E E +E +R QEE+ L E+++++RE E+ R Q E+
Sbjct: 350 MQEQEEKMWE-----------QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
Query: 623 ------------QRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKM 670
+R+RE+++++++V K+ E + E EE+ E EK
Sbjct: 399 MWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
Query: 671 AEKINDIAYEMESRRTYLQS---EEIVAELVYSFLIPEVQKYFVKEKVRNAQRK 721
+ + E E + + E+ E L + +K + +EK++ + K
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
Score = 42.4 bits (98), Expect = 0.002
Identities = 71/355 (20%), Positives = 148/355 (41%), Gaps = 44/355 (12%)
Query: 415 QPQIRAPKPKVITTKAGFLKRAARL---DYELAEVHKALLDKKNKVLEVKKPPRFLQRNP 471
+ ++R + K+ + ++ RL + ++ E + + ++ ++ E +K R ++
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
Query: 472 IPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHA 531
Q L +M EE+ E ++ + + ++E +++ E Q++R
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 532 L--QEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVR 589
++DE+L +K E+ ++ Q + E + E + + D + +
Sbjct: 398 RMWEQDERLREKEER-----MREQEKMWEQVEKMREEKKMQEQEKKTRDQEE-------K 445
Query: 590 LQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLED 649
+QEE RI ER++++RE EE+ R Q EK + +EE+ +E + + E
Sbjct: 446 MQEEERIR------EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499
Query: 650 IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKY 709
+ + EE +I + EKI D EM + + +E + E E Q +
Sbjct: 500 LWEQEKMQEQEE----KIWEQEEKIRD-QEEMWGQEKKMWRQEKMRE-------QEDQMW 547
Query: 710 FVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNE 764
+EK+R+ ++K E ++KK E E+ + E+E E
Sbjct: 548 EQEEKMRDQEQK---------MWDQEERMEKKTQEQEKKTWDQEEKMREEERMRE 593
Score = 42.0 bits (97), Expect = 0.002
Identities = 84/479 (17%), Positives = 191/479 (39%), Gaps = 46/479 (9%)
Query: 237 EVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE-- 294
E E R +E++ W Q ++ + M + E + W E+ EK + +R +
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEG-----KEAKMAKIQRTHVSTIRKLVGKRK 349
+ +++ + REE + + K + K+QE +E KM + + T K+ + +
Sbjct: 419 MWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 478
Query: 350 NI------EGKLERRNIIKD-------YSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYL 396
N+ E + +R K+ + +++ ++ + E+ + +
Sbjct: 479 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI-----RDQEEMWGQEKKM 533
Query: 397 NTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNK 456
E + E E Q+ + K+ + + R++ + E K D++ K
Sbjct: 534 WRQEKMREQED---------QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584
Query: 457 VLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGK 516
+ E ++ ++ + + +M EE+ E ++ + + + M+E +
Sbjct: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Query: 517 EKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRAL 576
EK E +++ L E ++ + + EK +Q Q + E + + E +E +
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEK-----MQEQEKMQEQEEKIWEQEK--MEKKTQ 697
Query: 577 ADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVV 636
+E +R +E R M E + +RE EE + Q EK + +E+E++++
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKM-REEEEMMREQEEKMQEQEEKMQ-EQEEEMWEQEE 755
Query: 637 KVHHSTISSYLEDIILNTEANTAEEQARAEIEKM---AEKINDIAYEMESRRTYLQSEE 692
K+ + + + + E + E EK+ EK+ D +M + ++ +E
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE 814
Score = 33.9 bits (76), Expect = 0.58
Identities = 58/274 (21%), Positives = 114/274 (41%), Gaps = 19/274 (6%)
Query: 488 EEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVT 547
E+EE E L + Q M E +EK E +++R + EK + + EK
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM-- 539
Query: 548 LALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQR 607
+ Q E K+ E + E R + +E +E ++ + ER++
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE---QEKKTWDQEEKMREEERMREREK 596
Query: 608 RVREAEESGRRQVEKQRLRE------EDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
++RE EE R Q EK + +E E++++++ K+ + ++ + + E
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEI-VAELVYSFLIPEVQKYFVKEKVRNAQ- 719
Q R +K EK+ + E + Q E+I E + + +K + +EK+R +
Sbjct: 657 QQRLPEQK--EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Query: 720 ----RKHILAAHQIIHSYTESMVQKKLTEGEQDE 749
K + +++ E M +++ EQ+E
Sbjct: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Score = 31.6 bits (70), Expect = 2.9
Identities = 77/459 (16%), Positives = 186/459 (40%), Gaps = 42/459 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRK 302
R REK+ E + +K+ + M E E KEW ++Q + + +E E +E +++
Sbjct: 453 REREKKMREEEETMREQEEKMQKQEENMWEQEEKEW--QQQRLPEQKEKLWE--QEKMQE 508
Query: 303 REEN--QNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNI 360
+EE + E ++ W G+E KM + ++ R+ + E+
Sbjct: 509 QEEKIWEQEEKIRDQEEMW-----GQEKKMWRQEKM-----------REQEDQMWEQEEK 552
Query: 361 IKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRA 420
++D +++ R+ + + + E + E E + + + +R
Sbjct: 553 MRDQEQ---KMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE--EEEMMRE 607
Query: 421 PKPKVITTKAGFLKRAARL---DYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRL 477
+ K+ + ++ ++ + ++ E + + +++ K+ E ++ QR P + +L
Sbjct: 608 QEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Query: 478 PTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEK 537
+ +E E + +K+ + Q +EK E ++E+E+
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
Query: 538 LVK----KAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL-------SKE 586
+++ K ++Q +++ + E + + E E + L + + L +E
Sbjct: 728 MMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 787
Query: 587 LVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
+ QEE+ + ++ ++R EE R Q EK +E++++ + K+ +
Sbjct: 788 KIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKM-WGQEEKMWGQEEKMWGQEEKMW 846
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRR 685
++ + + EE+ R + EKM + + + E R
Sbjct: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885
Score = 31.6 bits (70), Expect = 2.9
Identities = 30/130 (23%), Positives = 61/130 (46%), Gaps = 9/130 (6%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNE---MERKEWAFREQEIEKLQEI 291
Q ++E + +EK+ W+ + S E+ +KM E M +E +EQE EK+QE
Sbjct: 689 QEKMEKKTQEQEKKTWDQE-KMREEESMREREKKMREEEEMMREQEEKMQEQE-EKMQEQ 746
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQE----GKEAKMAKIQRTHVSTIRKLVGK 347
E+ ++ + E+ + + L + KL E ++ K+ + + K+ G+
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806
Query: 348 RKNIEGKLER 357
+ + G+ E+
Sbjct: 807 EEKMRGQEEK 816
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 53.1 bits (126), Expect = 9e-07
Identities = 107/557 (19%), Positives = 238/557 (42%), Gaps = 81/557 (14%)
Query: 266 RRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEVN-----MKHLNARWS 320
R K ++ ++ +EQ++ LQ ++L L+E L+++ N E+ K +
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQ-LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494
Query: 321 KLQEGKEAKMAKIQRTHVSTIRKLVGKRK---NIEGKLERRN-----IIKDYSDYASQVY 372
LQ+ AK+ + Q +R++ K + N+E L++ + K+ D +++
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
Query: 373 ---GPLSRLGCFPDNN----SEDFVVKNYYLNTYEGLVELESCLPDFVTQPQ--IRAPKP 423
G + L + N + + N E + + L D V + + +RA +
Sbjct: 555 AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD 614
Query: 424 KVITTKAGFLKRAARLDYELAEVHKA--LLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPT 481
+V++ + + ++L+ +V + + K ++L + + QR + Q L T
Sbjct: 615 RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL-QNHLDTAQ 673
Query: 482 LEMTSNEEE------EMEMAVIYLQ-KLLRGRVVQNMMFEGKEKRLELIQELRTCHA--- 531
+ ++E +++ LQ K +++ + E KEK L L Q+
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 532 -LQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRA--LADMFDFLSKELV 588
L+ D VK +++Q LQ+QR L+ LE RA L+ + + KE+V
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLN-----------TDLELRATELSKQLE-MEKEIV 781
Query: 589 ---RLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISS 645
RL +++ A + ++ + E EKQ L+++ E + K+ H +++
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEE---------EKQILKQDFETLSQETKIQHEELNN 832
Query: 646 YLEDIILNTEANTAEEQA-RAEIEKMAEKINDIA---------YEMESRR---TYLQSEE 692
++ + + E++A E+ + +K++ ++ +E E+++ L E+
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 693 IVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQI---IHSYTESMVQKK--LTEGEQ 747
EL + + +++++ + K A+HQ+ ++S E ++Q + L + E+
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 748 DEASNAAMLLEKETQNE 764
+E + E + +E
Sbjct: 953 EEQQLQGNINELKQSSE 969
Score = 34.3 bits (77), Expect = 0.45
Identities = 38/190 (20%), Positives = 79/190 (41%), Gaps = 32/190 (16%)
Query: 521 ELIQELRTCHALQEDEKLVKKAEKQ----VTLALQRQRNLHEHKVSLVENHLAGLEGRAL 576
+LIQEL+T A E + K+ + Q +Q++++L E ++ ++ LA +E
Sbjct: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE---- 1130
Query: 577 ADMFDFLSKELVRLQEERRIHAFVML-----------------------AERQRRVREAE 613
++ KE+ +L EE + H + A+ + E E
Sbjct: 1131 -EIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE 1189
Query: 614 ESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEK 673
+ ++ ++ Q +EE+E+ KE ++ S E + + E + +I + E
Sbjct: 1190 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249
Query: 674 INDIAYEMES 683
+ + E +S
Sbjct: 1250 LGTVKKEWQS 1259
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/299 (21%), Positives = 125/299 (41%), Gaps = 40/299 (13%)
Query: 476 RLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQ----ELRTCHA 531
R TL+ + + +++ ++L LRG+ E+R L+Q ELR
Sbjct: 1635 RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRA--T 1692
Query: 532 LQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
L++ E+ K AE+++ + +R + LH SL+ L +L++LQ
Sbjct: 1693 LEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKK-------------LETDLMQLQ 1739
Query: 592 EERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDII 651
E + + R R AEE ++ + + E+ ++ H + LE +
Sbjct: 1740 SE--------VEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1791
Query: 652 --LNTEANTAEEQA----RAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPE 705
L + AE+ A + +I+K+ +I ++ +E+E + +E + Y + E
Sbjct: 1792 KDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKK-NTESVKGLRKYERRVKE 1850
Query: 706 VQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNE 764
+ Y +E RK++L ++ + K E DE +NA + ++ Q+E
Sbjct: 1851 LT-YQSEE-----DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHE 1903
Score = 35.0 bits (79), Expect = 0.26
Identities = 96/518 (18%), Positives = 196/518 (37%), Gaps = 60/518 (11%)
Query: 285 IEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQ----------EGKEAKMAKIQ 334
+EK+ + L E K EE Q ++ L + S+LQ E KE+ ++++
Sbjct: 1246 LEKICRTLEDQLSEARGKNEEIQR--SLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Query: 335 RTHVSTIRKLVGKRKNIEGKLERRNIIKDY------------SDYASQVYGPLSRLGCFP 382
R+ + ++ ++ +E + + +N + Y + G
Sbjct: 1304 RSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Query: 383 DNNSEDFVVKNYY-LNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAAR--- 438
NSE + Y + + ELE + Q + + + K L++ +
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 439 -------LDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEE 491
+D E A A LDKK + + K + + Q L E S E
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFD-KVLAEWKTKCEESQAELEASLKESRSLSTEL 1482
Query: 492 MEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL----RTCHALQEDEKLVKKAEKQVT 547
++ Y + L + V+ +++ +L +++ +T H L++ K ++ + +
Sbjct: 1483 FKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 1542
Query: 548 LALQRQRNLHEH---KVSLVENHLAGLEG---RALADM---FDFLSKELVRLQE--ERRI 596
LAL+ EH K+ ++ L ++ R +A+ + L + R E + +
Sbjct: 1543 LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL 1602
Query: 597 HAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILN-TE 655
A V R+++ E ++E Q L + E +K H ++ L+D L+ +
Sbjct: 1603 DAEVRSRNEAIRLKKKMEGDLNEIEIQ-LSHANRQAAETLK-HLRSVQGQLKDTQLHLDD 1660
Query: 656 ANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKV 715
A +E + ++ + + N + E+E R L+ E +L L+ E+V
Sbjct: 1661 ALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS------NERV 1714
Query: 716 RNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNA 753
+ ++ H T+ M + E +A NA
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNA 1752
Score = 33.5 bits (75), Expect = 0.76
Identities = 66/356 (18%), Positives = 151/356 (42%), Gaps = 44/356 (12%)
Query: 434 KRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEME 493
K ++L+ ++ ++ +L +K +++++ R L+ + +L ++ N++++++
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL----KLAQESILDLENDKQQLD 1078
Query: 494 MAV-------IYLQKLLRGRVVQNMMFEGKEKRLEL-IQELRTCHALQEDEKLVKKAEKQ 545
+ LQ + + F+ K K L+ I+EL +E++ +AE+
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL--------EEEI--EAERA 1128
Query: 546 VTLALQRQRNLHEHKVSLVENHL--AGLEGRALADMFDFLSKELVRLQ---EERRI-HAF 599
++QR+ + ++ + L AG ++ E ++L+ EE + H
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 600 VMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDII-----LNT 654
++ A R++ E G + QR++++ E K K+ +SS +E + L
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 655 EANTAEEQ---ARAEIEKMAEKINDIAYEM--------ESRRTYLQSEEIVAELVYSFLI 703
T E+Q AR + E++ ++++ + E R + E IV++L S
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308
Query: 704 PEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEK 759
Q +K ++ + AH + S + + ++ E EQ+ + L K
Sbjct: 1309 FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 51.2 bits (121), Expect = 4e-06
Identities = 100/534 (18%), Positives = 214/534 (40%), Gaps = 55/534 (10%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
Q E ++ R+K A + S ++ E RK + EME K+ +EI K + E
Sbjct: 353 QKAEEELQELRDKIA-KGECGNSSLMAEVENLRKRVLEMEGKD-----EEITKTESQCRE 406
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
+ K+L + E + K L KLQ+ + +++ K++ + + N+E
Sbjct: 407 LRKKL------QEEEHHSKELRLEVEKLQK-RMSELEKLEEAFSKSKSECTQLHLNLE-- 457
Query: 355 LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVT 414
+ +N+ KD + V + L C ++ L+ + L +L+S V
Sbjct: 458 -KEKNLTKDLLNELEVVKSRVKELECSESR------LEKAELSLKDDLTKLKSFTVMLVD 510
Query: 415 QPQIRAPKPKVITTKAGFLKRAARLDY-ELAEVHKALLDKKNKVLEVKKPPRFLQRNPIP 473
+ + K K K L + +++ ++ +V + L+++ K+L++K N
Sbjct: 511 ERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTR 570
Query: 474 QPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRG-RVVQNMMFEGKEKRLELIQELRTCHAL 532
+ L+ + E+ +V L+K L G V+ + G+ ++ + TC
Sbjct: 571 ERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSEL----TC--- 623
Query: 533 QEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQE 592
ED K+ K++TL ++R + + ++ +VE L E D +D L ++ Q+
Sbjct: 624 PEDNKI-----KELTLEIERLKKRLQ-QLEVVEGDLMKTE-----DEYDQLEQKFRTEQD 672
Query: 593 ERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIIL 652
+ + + E + Q+ K + E+ E+ + ++ H + L
Sbjct: 673 KANF------------LSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
Query: 653 NTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVK 712
E +E+ E+ ++++ + + + EE + + ++ ++ +
Sbjct: 721 KAEVQALKEKIH-ELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELS 779
Query: 713 EKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNENN 766
++ A R + + T + VQ GE E A+ + K Q EN+
Sbjct: 780 KRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENH 833
Score = 43.5 bits (101), Expect = 7e-04
Identities = 113/594 (19%), Positives = 251/594 (42%), Gaps = 110/594 (18%)
Query: 237 EVEMIERAREKRAWEASLPALSDTSQFEKRRKMM----NEMERKEWAFREQEIEKL-QEI 291
E E +AR+++ L L D K +M +M ++ + Q+++ L Q++
Sbjct: 216 EQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKL 275
Query: 292 RLEV--LKELLRKREENQN-----EVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIR-K 343
R E LK + K +E++ EV+ +H +R+S+ E AK+A Q +H +R K
Sbjct: 276 REEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLAN-QESHNRQLRLK 334
Query: 344 LVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLV 403
LVG + IE E ++ + ++ +++ C N+S V+ N + ++
Sbjct: 335 LVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGEC--GNSSLMAEVE----NLRKRVL 388
Query: 404 ELESCLPDFV-TQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKK 462
E+E + T+ Q R + K+ + + RL+ E + + L+K + K
Sbjct: 389 EMEGKDEEITKTESQCRELRKKL--QEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSK 446
Query: 463 PPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLEL 522
L + +E+ + ++ ++++ RV + E + ++ EL
Sbjct: 447 S--------------ECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAEL 492
Query: 523 IQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGL------EGRAL 576
+L++D + K + + + ++N+ E K+ E + GL E +
Sbjct: 493 --------SLKDD---LTKLKSFTVMLVDERKNMME-KIKQEERKVDGLNKNFKVEQGKV 540
Query: 577 ADMFDFL---SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVE--------KQRL 625
D+ + L SK+L++L+ E + + ER + + + + E K+RL
Sbjct: 541 MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL 600
Query: 626 REEDEIFKEVV----------------KVHHSTIS-----------SYLEDIILNT--EA 656
+E+ +E+ K+ T+ +E ++ T E
Sbjct: 601 DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY 660
Query: 657 NTAEEQARAEIEK---MAEKINDIAYEMESRRTYLQSEEI--VAELVYSFLIPEVQKYFV 711
+ E++ R E +K +++++ +I +++ + + E + AEL + F + E + +
Sbjct: 661 DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
Query: 712 KEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNEN 765
K +V+ + K H++++ + +L++ + D + +E+E +N+N
Sbjct: 721 KAEVQALKEK----IHELMNK------EDQLSQLQVDYSVLQQRFMEEENKNKN 764
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 50.4 bits (119), Expect = 6e-06
Identities = 113/499 (22%), Positives = 205/499 (41%), Gaps = 93/499 (18%)
Query: 244 AREKRAWEASLPALSDTSQFEKRRKMMNEM---------ERKEWAFREQEIEKLQEIRLE 294
A+ K+ E L S+F K +K+M + E +E A +I QE+ +
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 295 VLKELLRKREENQNEVN--MKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIE 352
L+E L+K E+ + E+ + L+ + LQ+ ++A++Q +L K + ++
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQD----QIAELQAQIDELKLQLAKKEEELQ 1093
Query: 353 GKLER--------RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGL-V 403
G L R N +K + +Q+ + ++ K E L
Sbjct: 1094 GALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKT 1153
Query: 404 ELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK-KNKVLEVKK 462
ELE L Q ++R + + E+AE+ KAL ++ KN +++
Sbjct: 1154 ELEDTLDTTAAQQELRTKR-----------------EQEVAELKKALEEETKNHEAQIQD 1196
Query: 463 PPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRG------------RVVQN 510
QR+ LE S + E+ + L+K +G +V+Q
Sbjct: 1197 ---MRQRH--------ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 511 MMFEGKEKRLELIQELRTCHA-LQEDEKL-VKKAEKQVTLALQRQRNLHEHKVSLVENHL 568
+ E + KR +L +++ HA + E ++L V+ AEK A + Q L L E
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK----ASKLQNELDNVSTLLEEAEK 1301
Query: 569 AGLE-GRALADMFDFLSKELVRLQEERRIHAFVMLAERQ--------RRVREAEESGRRQ 619
G++ + A + L LQEE R + RQ + +E EE R+
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 620 VEKQRLREEDEIFKEVVKVHH--STISSYLE---DIILNTEA--NTAEEQARA--EIEK- 669
+EKQ L + ++ KV TI S E ++ + EA EE+A A ++EK
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 670 ---MAEKINDIAYEMESRR 685
+ ++++D+ +++ +R
Sbjct: 1422 KNRLQQELDDLTVDLDHQR 1440
Score = 42.4 bits (98), Expect = 0.002
Identities = 103/498 (20%), Positives = 221/498 (44%), Gaps = 57/498 (11%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKM-----MNEMERKEWAFREQEIEKLQ 289
+AE + I+ A++ + E+ L + Q E R+K+ + ++E ++ + +EQ+ E+ +
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE-E 1356
Query: 290 EIRLEVLKELLR--------KREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTI 341
E R + K++L K++ + + ++ L KL + EA +++ ++
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA-Y 1415
Query: 342 RKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGC-FPDNNSEDFVVKNYYLNTYE 400
KL + ++ +L+ + D+ QV L + F +E+ + Y +
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQ---RQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Query: 401 GLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEV 460
E E+ + RA + + + K F ++ +L ++ ++ + D V E+
Sbjct: 1473 R-AEAEAREKETKALSLARALE-EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 461 KKPPRFLQRNPIPQPRLPTPTLE--MTSNEEEEMEMAV-IYLQKLLRGRVVQNMMFEGKE 517
+K R L++ + + R LE + + E+ ++ + V + K R +Q + +E
Sbjct: 1531 EKSKRALEQQ-VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEE 1589
Query: 518 KRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGR--A 575
K+ LI+++R A EDE+ KQ LA+ ++ + E L LE + A
Sbjct: 1590 KKRLLIKQVRELEAELEDER------KQRALAVASKKKM--------EIDLKDLEAQIEA 1635
Query: 576 LADMFDFLSKELVRLQEERRIHAFVM---LAERQRRVREAEESGR--RQVEKQRLREEDE 630
D + K+L +LQ + + + + A R +++ES + + +E + L+ ++E
Sbjct: 1636 ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695
Query: 631 I-FKEVVKVHHSTISSYLEDIILNTEANTA-----EEQARAEIEKMAEKINDIAYEME-- 682
+ E + H L D I N+ + + + + A I ++ E++ + ME
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Query: 683 ---SRRTYLQSEEIVAEL 697
R+T LQ + + AEL
Sbjct: 1756 NDRFRKTTLQVDTLNAEL 1773
Score = 40.0 bits (92), Expect = 0.008
Identities = 70/369 (18%), Positives = 156/369 (42%), Gaps = 47/369 (12%)
Query: 426 ITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEV--------KKPPRFLQRNPIPQPRL 477
+ TK L + R + EL + LL K K +V +K + L+ I +L
Sbjct: 837 VFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL 896
Query: 478 PTPTLEMTSNEE---------EEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLEL-IQELR 527
T EE +E+E + L+ + +N + + ++K+++ IQ+L
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 528 TCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGL-EGRALADMFDFLSKE 586
L E+E +K + + A + + + E + L + + + E + + D S +
Sbjct: 957 --EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014
Query: 587 LVRLQEERRIHAF------VMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHH 640
L +E+ + A VM+++ + R+++ EE R+++EK + + + E
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEERLKK-EEKTRQELEKAKRKLDGE---------- 1063
Query: 641 STISSYLEDIILNTEANTAE---EQARAEIE---KMAEKINDIAYEMESRRTYLQSEEIV 694
++ L+D I +A E + A+ E E +A ++ ++ + + + + +
Sbjct: 1064 ---TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 695 AELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAA 754
AEL F + + +++ R+ + ++ + + Q++L + E +
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 755 MLLEKETQN 763
LE+ET+N
Sbjct: 1181 KALEEETKN 1189
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 50.4 bits (119), Expect = 6e-06
Identities = 112/585 (19%), Positives = 230/585 (39%), Gaps = 85/585 (14%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
Q + EM E+ REK E F+ + MNE ++ ++ E+E L E
Sbjct: 637 QYQTEM-EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSE 695
Query: 295 VLKELLRKREE-----NQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRK 349
VLK + EE +Q + + L A+ + + + ++ I + H +I++ K
Sbjct: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 350 NIEGKL-----ERRNIIKDYSDYASQVYGPLSRL-GCFPDNNSEDFVVKNYYLNTY---- 399
+ +L ER +K++ + + + R G +++ V ++Y T+
Sbjct: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Query: 400 ---EGLVELESCLPDFVTQ--------PQIRAPKPKVIT-------TKAGFLKRAARLDY 441
E L +L+ L D T+ ++ A K V T +++ + +
Sbjct: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875
Query: 442 E-------LAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEM 494
E L +V+++ L+ NK E K + N I L+M +++E+E+
Sbjct: 876 EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI---------LQMREGQKKEIEI 926
Query: 495 AVIYLQKLLRGRVVQNMMFEGK----EKRLELI-------QELRTCHALQEDEKLVKKAE 543
L + N +E K EK++E + QE L ++ KL K+ E
Sbjct: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
Query: 544 KQVTLALQRQRNLHEHKVSLVENHLAGLEG---------------------RALADMFDF 582
Q+++ + + + + + AG+ R L D+
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISI 1046
Query: 583 LSKELVRLQEERRIHAFVMLAERQRRVREAEESGRR-QVEKQRLREEDEIFKEVVKVHHS 641
K+L + EE + + L E+++ V E ++ EK+ + +E KE +
Sbjct: 1047 WEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
Query: 642 TISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSF 701
T++ E + + + Q +++ EK+ + T+LQ + + +++
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEE 1166
Query: 702 LIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTE--SMVQKKLTE 744
+V + K K + + + + ++H+ + E S+ KKL+E
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Score = 47.8 bits (112), Expect = 4e-05
Identities = 117/574 (20%), Positives = 234/574 (40%), Gaps = 131/574 (22%)
Query: 246 EKRAWEASLPALSDTSQFEK-RRKMMNEMERK----------EWAFREQEIEKLQEIRLE 294
E+ A+E ALS + E+ RRK+ EM+ + E +QE+ ++++ ++
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
V+K + E ++AK+Q+ H ++L K + + K
Sbjct: 469 VMK--------------------------KSSEEQIAKLQKLHE---KELARKEQELTKK 499
Query: 355 LERR-----NIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCL 409
L+ R +K + + Y +S+ E ++ L L E E+ L
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQ----EKEQQESLALEELELQKKAILTESENKL 555
Query: 410 PDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNK-----VLEVKKPP 464
D Q + + +++ ++ K + ++ L +KNK + V+K
Sbjct: 556 RDL--QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613
Query: 465 RFLQRNPIPQPRLPTPTLEMTSNE-----EEEMEMAVIYLQKLLRGR--VVQNMMFEGKE 517
L+ Q L T L++ + E+ E + LL+ + + Q + E E
Sbjct: 614 TELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Query: 518 KRL---------------ELIQELRTCHALQEDEKLVK----KAEKQVTLALQRQRNLHE 558
K L EL + L+ H L+E+ ++K K ++++ + Q+N H+
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ 733
Query: 559 HKV-SLVENHLAGLE--GRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAE-E 614
+V S+++ H ++ +AL D + +L L +ER H L E Q V E +
Sbjct: 734 QQVDSIIKEHEVSIQRTEKALKDQIN----QLELLLKERDKH----LKEHQAHVENLEAD 785
Query: 615 SGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDII--------LNTEANTAEEQARAE 666
R + E Q+ + ++F+ H +Y E + L TE +Q AE
Sbjct: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV-AE 844
Query: 667 IEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAA 726
+E A+K D+ E+++ + +Q ++++ +L E Q +++KV++ +
Sbjct: 845 VE--AQK-KDVCTELDAHK--IQVQDLMQQL-------EKQNSEMEQKVKSLTQ------ 886
Query: 727 HQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKE 760
+ + KL +G +++ +L+EKE
Sbjct: 887 ----------VYESKLEDGNKEQEQTKQILVEKE 910
Score = 47.0 bits (110), Expect = 7e-05
Identities = 113/551 (20%), Positives = 236/551 (42%), Gaps = 97/551 (17%)
Query: 251 EASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEV 310
E L AL D + E K+ E++RK EQ+I +++ L ++E +EE +
Sbjct: 1619 EEELKALEDRLESESAAKLA-ELKRKA----EQKIAAIKKQLLSQMEE----KEEQYKKG 1669
Query: 311 NMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNII----KDYSD 366
HL+ +KLQE + + H+ L K K++E I+ K+ +
Sbjct: 1670 TESHLSELNTKLQERE-------REVHI-----LEEKLKSVESSQSETLIVPRSAKNVAA 1717
Query: 367 YASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVI 426
Y Q GC E V L E L++ ++ K + +
Sbjct: 1718 YTEQEEADSQ--GCVQKTYEEKISVLQRNLTEKEKLLQ------------RVGQEKEETV 1763
Query: 427 TT----KAGFLKRAARLDYELAEVHK--ALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTP 480
++ + + +R +L++ A+ H+ +++ + LE K L I +
Sbjct: 1764 SSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL----IVAQHVEKE 1819
Query: 481 TLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLE--LIQELRTCHALQEDEKL 538
+ ++ +E +QK L+ + + + E K K L+ L+++ + H + E E+L
Sbjct: 1820 GGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ-KEVHRV-EMEEL 1877
Query: 539 VKKAEKQVTLALQRQRN-----LHEHKVSLVENHLAGLEGRALADM------FDF----- 582
K EK L RN L E+ ++HL ++ + L++M +F
Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHL--VQPKLLSNMEAQHNDLEFKLAGA 1935
Query: 583 ------LSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVV 636
L KE+VRLQ++ R ML + ++ E + Q ++++++E E ++
Sbjct: 1936 EREKQKLGKEIVRLQKDLR-----MLRKEHQQELEILKKEYDQEREEKIKQEQE---DLE 1987
Query: 637 KVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-MESRRTYLQSEEIVA 695
H+ST+ + + NT+ E++ I++ K ++ E +ES + ++ +++
Sbjct: 1988 LKHNSTLKQLMRE--FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE--ETNQLLK 2043
Query: 696 ELVY--SFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDE--AS 751
++ L ++Y E++ +A+ + + A + + + E + +K + EQ+E +
Sbjct: 2044 KIAEKDDDLKRTAKRY---EEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGN 2100
Query: 752 NAAMLLEKETQ 762
+ ++E +TQ
Sbjct: 2101 DNVTIMELQTQ 2111
Score = 40.8 bits (94), Expect = 0.005
Identities = 82/429 (19%), Positives = 170/429 (39%), Gaps = 67/429 (15%)
Query: 283 QEIEKLQEIRLEVLKELLRKREE------NQNEVNMKHLNARWSKLQEGKEAKMAKIQRT 336
Q+ K QE L+ KE ++ +E ++ E + L+ R +L++ K+ MA+
Sbjct: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE---- 340
Query: 337 HVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYL 396
K K I + +N+I+ V R E +K
Sbjct: 341 ----------KTKLITQLRDAKNLIEQLEQDKGMVIAETKR------QMHETLEMKE--- 381
Query: 397 NTYEGLVELESCLPDFVTQ-PQIRAPKPKVITTKAGFLKRAARLDYELAEVH---KALLD 452
E + +L S + TQ ++R K K L++A + E KA +D
Sbjct: 382 ---EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMD 438
Query: 453 KKNKVLE-VKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNM 511
++ K +E + R + + + + + S+EE+ ++ ++ ++L R
Sbjct: 439 EQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTK 498
Query: 512 MFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGL 571
+ +E+ + ++ + E K+ ++ E+Q +LAL+ + ++ EN L L
Sbjct: 499 KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL 558
Query: 572 EGRA------LADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRL 625
+ A + ++ L K L + + + A + AE+ + +E VEK +
Sbjct: 559 QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV----MVEKHK- 613
Query: 626 REEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRR 685
E+ + H +D + + ++Q + E+EK+ EK + +
Sbjct: 614 -------TELESLKHQ------QDALWTEKLQVLKQQYQTEMEKLREKCE------QEKE 654
Query: 686 TYLQSEEIV 694
T L+ +EI+
Sbjct: 655 TLLKDKEII 663
Score = 30.4 bits (67), Expect = 6.5
Identities = 51/253 (20%), Positives = 112/253 (44%), Gaps = 39/253 (15%)
Query: 526 LRTCHALQEDEKLVKKAEKQVTLALQRQRNLH--EHKVSLVENHLAGLEGRALADMFDFL 583
++TC + + +L + E+Q TL + Q+ H E K + +++ A +E +L + L
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE--SLVTEKEAL 1323
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE Q+ +E++ + + ++ + L +E+ KE KV S++
Sbjct: 1324 QKEGGNQQQ--------AASEKESCITQLKKELSENINAVTLMKEE--LKE-KKVEISSL 1372
Query: 644 SSYLEDI---ILNTEANTAEEQARAEIEK--------MAEKINDIAYEMESRRTYLQSEE 692
S L D+ + N+ + + +E A + + K + +++ D+++++++ L E+
Sbjct: 1373 SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT----LSKEK 1428
Query: 693 IVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASN 752
I A + +V + K + + HQ ++ E +Q +L E E
Sbjct: 1429 ISA-------LEQVDDWSNKFSEWKKKAQSRFTQHQ--NTVKELQIQLELKSKEAYEKDE 1479
Query: 753 AAMLLEKETQNEN 765
LL++E +N
Sbjct: 1480 QINLLKEELDQQN 1492
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 50.4 bits (119), Expect = 6e-06
Identities = 103/483 (21%), Positives = 188/483 (38%), Gaps = 62/483 (12%)
Query: 170 PYTFPPTSTKHLSIPSKSTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGR 229
P T PP +P G Q D + + P Y Q+ P+ +
Sbjct: 319 PLTLPPEL-----VPPSFRGGKQIDSINGTL------PSYQKMQEEEPQ----------K 357
Query: 230 GLPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEME---RKEWAFREQEIE 286
LP + R E AL + Q E RK E E RK+ +EQE +
Sbjct: 358 KLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWK 417
Query: 287 KLQEI--RLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHV------ 338
K E+ RLE +EL R+REE + + +++ A +L+ + + +I+R +
Sbjct: 418 KQLELEKRLEKQRELERQREEERRK-DIERREAAKQELERQRRLEWERIRRQELLNQKNR 476
Query: 339 --STIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLS--RLGCFPDNNSEDFVVKNY 394
I +L K+KN+ +LE N Q+ G L RL + + K
Sbjct: 477 EQEEIVRLNSKKKNLHLELEALN------GKHQQISGRLQDVRLKKQTQKTELEVLDKQC 530
Query: 395 YLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKK 454
L E + +L+ L ++ + P+ +++ + ++ + D ++ +HK L+K+
Sbjct: 531 DLEIME-IKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
Query: 455 NKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR----GRVVQN 510
+K+ L++ + EM S + E+ Y + L ++ ++
Sbjct: 590 ELCQRLKEQLDALEK------ETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRD 643
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAG 570
+ E + KRLEL+Q+ + EDE K + + L + R E K ++
Sbjct: 644 KLKEIERKRLELMQKKKL-----EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQ 698
Query: 571 ---LEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLRE 627
E A+ K+ ++ +E++R A V++ R EA + +
Sbjct: 699 EKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQ 758
Query: 628 EDE 630
DE
Sbjct: 759 VDE 761
Score = 36.6 bits (83), Expect = 0.090
Identities = 67/295 (22%), Positives = 109/295 (36%), Gaps = 91/295 (30%)
Query: 463 PPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLEL 522
PP F I P+ + EE + ++ V + K NM E KR +
Sbjct: 328 PPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELE---KRRQA 384
Query: 523 IQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDF 582
+ E Q+ + +KA+K+ ++QR L E + LE
Sbjct: 385 LME-------QQQREAERKAQKEKEEWERKQRELQEQEWK------KQLE---------- 421
Query: 583 LSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRL----------------- 625
L K RL+++R + ERQR ++ RR+ KQ L
Sbjct: 422 LEK---RLEKQREL-------ERQREEERRKDIERREAAKQELERQRRLEWERIRRQELL 471
Query: 626 ----REEDEIFK------------EVVKVHHSTISSYLEDIIL-----NTEANTAEEQAR 664
RE++EI + E + H IS L+D+ L TE ++Q
Sbjct: 472 NQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCD 531
Query: 665 AEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQ 719
EI ME ++ + +E +L+Y L+PE K + E+++N Q
Sbjct: 532 LEI-------------MEIKQLQQELQEYQNKLIY--LVPE--KQLLNERIKNMQ 569
>gi|100814339 coiled-coil domain containing 146 [Homo sapiens]
Length = 955
Score = 49.7 bits (117), Expect = 1e-05
Identities = 98/510 (19%), Positives = 207/510 (40%), Gaps = 75/510 (14%)
Query: 264 EKRRKMMNEMER-KEWAFREQ-EIEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSK 321
E+ K NE KE F Q + L+E ++ ++KE + + + E MK L +
Sbjct: 125 EQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEE 184
Query: 322 LQEG---KEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRL 378
L++ K+ ++ ++ S ++L+ ++K +E L + ++KD + + + +
Sbjct: 185 LRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGK- 243
Query: 379 GCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAAR 438
E+E +T+ ++ K K++ +
Sbjct: 244 -------------------------EIEK-----ITRKKVEMEKKKIVLEQ-----EVKT 268
Query: 439 LDYELAEVHK---ALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMA 495
L+ L +V A++D+K V++ + R L + LE+ E
Sbjct: 269 LNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTE 328
Query: 496 VIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRN 555
L LR ++ + + R + +E R L++ E L+K + AL++ +
Sbjct: 329 RGILDLNLRNSLIDKQNYHDELSRKQREKE-RDFRNLRKMELLLKVSWD----ALRQTQA 383
Query: 556 LHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERR-IHAFVMLAERQRRVREAEE 614
LH+ R L +M + + K+ L E RR +H V +A+R ++
Sbjct: 384 LHQ---------------RLLLEM-EAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIIS 427
Query: 615 SGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAE-EQARAEIEKMAEK 673
++ +Q+L EE+++ KE + + +++ T+ E EQ + K +K
Sbjct: 428 EMESKLVEQQLAEENKLLKE-----QENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQK 482
Query: 674 INDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSY 733
+I EM+++ ++ + +Y L + Y + +RN + K + H+
Sbjct: 483 YTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLY---DTIRNERNKFVNLLHKAHQKV 539
Query: 734 TESMVQKKLTEGEQDEASNAAMLLEKETQN 763
E + K++ E + N+A+ E++ QN
Sbjct: 540 NEIKERHKMSLNELEILRNSAVSQERKLQN 569
>gi|156104874 envoplakin [Homo sapiens]
Length = 2033
Score = 49.3 bits (116), Expect = 1e-05
Identities = 113/578 (19%), Positives = 235/578 (40%), Gaps = 88/578 (15%)
Query: 192 QTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWE 251
Q +D ++Q D Y + S+ L ++ R P Q ++ E+ K E
Sbjct: 815 QAALQDYELQADTY-------RCSLEPTLAVSAPKRPRVAPL-QESIQAQEKNLAKAYTE 866
Query: 252 ASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEVN 311
+ Q E RKM+ + E E R + ++ E + RE +
Sbjct: 867 VAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQA------GRESEALKAQ 920
Query: 312 MKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQV 371
++ R +++Q EA QR+ + +R ++ +E +LE + +++ Y D Q+
Sbjct: 921 LEEERKRVARVQHELEA-----QRSQLLQLRT----QRPLE-RLEEKEVVEFYRD--PQL 968
Query: 372 YGPLSRLGCFPDNNSEDFVVKNYYLNTY-EGLVELESCLPDFVTQPQIRAPKPKVITTKA 430
G LSR+ + + L + +V+LES + + +P ++T +
Sbjct: 969 EGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLES---------KRKTMQPHLLTKEV 1019
Query: 431 GFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEE 490
++R LD + A++ + + + + + RL E+ + E+
Sbjct: 1020 TQVERDPGLDSQAAQLRIQIQQLRGE-------------DAVISARLEGLKKELLALEKR 1066
Query: 491 EMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLAL 550
E+++ +K++ VV+ EK LE+++ + E++ +K ++ L
Sbjct: 1067 EVDVK----EKVVVKEVVK------VEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKL 1116
Query: 551 QRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVR 610
Q ++ +E ++ +E + + + ++ LQE R+ + ++ ER +
Sbjct: 1117 QA-------RIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRS-LLEEERTKNAT 1168
Query: 611 EAEE-----SGRRQVEKQRLREE-DEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQA- 663
A E S VEKQR + + E E+ +V T E I +A E
Sbjct: 1169 LARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPET-----EQEITRLKAKLQEMAGK 1223
Query: 664 RAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHI 723
R+ +EK EK+ + +++ ++ +E+ E+V PEV + + K +
Sbjct: 1224 RSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQ------- 1276
Query: 724 LAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKET 761
+++++S+ S Q +GE+DE +E +T
Sbjct: 1277 --LNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKT 1312
Score = 45.4 bits (106), Expect = 2e-04
Identities = 97/488 (19%), Positives = 201/488 (41%), Gaps = 81/488 (16%)
Query: 234 GQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKL-QEIR 292
G+++ ++I E+ W + ++ E + + ++ E+E E+L QE+R
Sbjct: 1285 GRSQEQLIRLQGERDEWRR------ERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVR 1338
Query: 293 LEVLKELLRKREENQNEVNMKHLNARWSKLQEG----------KEAKMAKIQRTHVSTIR 342
K R E+ E+ K L K +E K+ K+ + ++
Sbjct: 1339 EAAQKR--RAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLD 1396
Query: 343 KLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGL 402
+ VG+R+ +E ++++ + + G LS F ++ S+ V+ +
Sbjct: 1397 EEVGRRRQLELEVQQLRAGVEEQE------GLLS----FQEDRSKKLAVERELRQLTLRI 1446
Query: 403 VELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKK 462
ELE P + K+I + L++ L+ + L +K +V E+ +
Sbjct: 1447 QELEKRPPTV---------QEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNR 1497
Query: 463 PPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRL-E 521
+ LQ + L+ ++E+ + VI +QK + + E + R+ E
Sbjct: 1498 ECKNLQ--------VQIDVLQKAKSQEKTIYKEVIRVQK--------DRVLEDERARVWE 1541
Query: 522 LIQELRTCHALQEDE--KLVKKAEKQVTLA---------LQRQRNLHEHKVSLVENHLAG 570
++ RT +E+E +L ++ ++ TL LQR R+ + + ++ L
Sbjct: 1542 MLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRA 1601
Query: 571 LEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDE 630
LE + ++ ++LQEE ++ + +ERQ+ + +E R +E LRE+D+
Sbjct: 1602 LERQK--------QQQTLQLQEESKLLSQKTESERQKAAQRGQELSR--LEAAILREKDQ 1651
Query: 631 IFKE---VVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE--MESRR 685
I+++ + +H L E N + + + E E + AY+ + R
Sbjct: 1652 IYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRG 1711
Query: 686 TYLQSEEI 693
YLQ +E+
Sbjct: 1712 QYLQLQEL 1719
Score = 40.0 bits (92), Expect = 0.008
Identities = 76/346 (21%), Positives = 146/346 (42%), Gaps = 42/346 (12%)
Query: 434 KRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEME 493
K A RL E+ E + ++ V E++ L+R P+ ++ + +T + + E
Sbjct: 1328 KEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRK-PEEKVVVQEVVVTQKDPKLRE 1386
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLEL-IQELRTCHALQEDEKLVKKAEKQVTLALQR 552
L G + + + G+ ++LEL +Q+LR ++E E L+ E + + L
Sbjct: 1387 E-----HSRLSGSLDEEV---GRRRQLELEVQQLRA--GVEEQEGLLSFQEDR-SKKLAV 1435
Query: 553 QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVM-----LAERQR 607
+R L + + + E LE R + +E+V+L+++ + L + +
Sbjct: 1436 ERELRQLTLRIQE-----LEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKT 1490
Query: 608 RVREAE-ESGRRQVEKQRLR----EEDEIFKEVVKVHHSTISSYLEDI------ILNTE- 655
+V E E QV+ L+ +E I+KEV++V + LED +LN E
Sbjct: 1491 QVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRV---LEDERARVWEMLNRER 1547
Query: 656 -ANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEK 714
A A E+ + + ++ + + LQ A+ L E++ E+
Sbjct: 1548 TARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRAL---ER 1604
Query: 715 VRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKE 760
+ Q + +++ TES QK G++ AA+L EK+
Sbjct: 1605 QKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKD 1650
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 49.3 bits (116), Expect = 1e-05
Identities = 102/484 (21%), Positives = 193/484 (39%), Gaps = 71/484 (14%)
Query: 170 PYTFPPTSTKHLSIPSKSTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGR 229
P T PP +P G Q D + + P Y Q+ P+ +
Sbjct: 319 PLTLPPEL-----VPPSFRGGKQIDSINGTL------PSYQKMQEEEPQ----------K 357
Query: 230 GLPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEME---RKEWAFREQEIE 286
LP + R E AL + Q E RK E E RK+ +EQE +
Sbjct: 358 KLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWK 417
Query: 287 KLQEI--RLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHV------ 338
K E+ RLE +EL R+REE + + +++ A +L+ + + +I+R +
Sbjct: 418 KQLELEKRLEKQRELERQREEERRK-DIERREAAKQELERQRRLEWERIRRQELLNQKNR 476
Query: 339 --STIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLS--RLGCFPDNNSEDFVVKNY 394
I +L K+KN+ +LE N Q+ G L RL + + K
Sbjct: 477 EQEEIVRLNSKKKNLHLELEALN------GKHQQISGRLQDVRLKKQTQKTELEVLDKQC 530
Query: 395 YLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKK 454
L E + +L+ L ++ + P+ +++ + ++ + D ++ +HK L+K+
Sbjct: 531 DLEIME-IKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
Query: 455 NKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFE 514
+K+ L++ + ++ +N+ + M LQ LL N +F
Sbjct: 590 ELCQRLKEQLDALEKETASK----LSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF- 644
Query: 515 GKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVE-NHLAGLEG 573
L++ELR + Q+ E+ + + + + ++ L++ L
Sbjct: 645 ------LLLKELRETYNTQQ-----LALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA 693
Query: 574 RALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFK 633
R + L KE +R +EE E+Q+R++E + + Q E+++ E+ K
Sbjct: 694 RKAKQGKENLWKENLRKEEE----------EKQKRLQEEKTQEKIQEEERKAEEKQRKDK 743
Query: 634 EVVK 637
+ +K
Sbjct: 744 DTLK 747
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 49.3 bits (116), Expect = 1e-05
Identities = 102/484 (21%), Positives = 193/484 (39%), Gaps = 71/484 (14%)
Query: 170 PYTFPPTSTKHLSIPSKSTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGR 229
P T PP +P G Q D + + P Y Q+ P+ +
Sbjct: 319 PLTLPPEL-----VPPSFRGGKQIDSINGTL------PSYQKMQEEEPQ----------K 357
Query: 230 GLPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEME---RKEWAFREQEIE 286
LP + R E AL + Q E RK E E RK+ +EQE +
Sbjct: 358 KLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWK 417
Query: 287 KLQEI--RLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHV------ 338
K E+ RLE +EL R+REE + + +++ A +L+ + + +I+R +
Sbjct: 418 KQLELEKRLEKQRELERQREEERRK-DIERREAAKQELERQRRLEWERIRRQELLNQKNR 476
Query: 339 --STIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLS--RLGCFPDNNSEDFVVKNY 394
I +L K+KN+ +LE N Q+ G L RL + + K
Sbjct: 477 EQEEIVRLNSKKKNLHLELEALN------GKHQQISGRLQDVRLKKQTQKTELEVLDKQC 530
Query: 395 YLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKK 454
L E + +L+ L ++ + P+ +++ + ++ + D ++ +HK L+K+
Sbjct: 531 DLEIME-IKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
Query: 455 NKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFE 514
+K+ L++ + ++ +N+ + M LQ LL N +F
Sbjct: 590 ELCQRLKEQLDALEKETASK----LSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF- 644
Query: 515 GKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVE-NHLAGLEG 573
L++ELR + Q+ E+ + + + + ++ L++ L
Sbjct: 645 ------LLLKELRETYNTQQ-----LALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA 693
Query: 574 RALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFK 633
R + L KE +R +EE E+Q+R++E + + Q E+++ E+ K
Sbjct: 694 RKAKQGKENLWKENLRKEEE----------EKQKRLQEEKTQEKIQEEERKAEEKQRKDK 743
Query: 634 EVVK 637
+ +K
Sbjct: 744 DTLK 747
>gi|4758648 kinesin family member 5B [Homo sapiens]
Length = 963
Score = 48.9 bits (115), Expect = 2e-05
Identities = 106/493 (21%), Positives = 200/493 (40%), Gaps = 97/493 (19%)
Query: 294 EVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEG 353
E + +L ++ ++ E+N + S+L E + +M + ST R + N++
Sbjct: 423 EEIAKLYKQLDDKDEEINQQ------SQLVEKLKTQMLDQEELLASTRRD----QDNMQA 472
Query: 354 KLERRNIIKDYS-DYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDF 412
+L R D S + +V L L D S++ K + +S
Sbjct: 473 ELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSA---- 528
Query: 413 VTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPI 472
T I A K+ KRAA + +A + K L + V N +
Sbjct: 529 -TLASIDAELQKLKEMTNHQKKRAAEM---MASLLKDLAEIGIAV----------GNNDV 574
Query: 473 PQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL 532
QP E T +EE +A +Y+ K+ V+ M+ KR + ++ +T
Sbjct: 575 KQP-------EGTGMIDEEFTVARLYISKMKSE--VKTMV-----KRCKQLESTQT---- 616
Query: 533 QEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEG--RALADMFDFLSKELVRL 590
E K +++ EK++ A Q + + HE K+ + +L +E R L + D LS+ELV+L
Sbjct: 617 -ESNKKMEENEKELA-ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQL 674
Query: 591 QEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDI 650
+ + ++H M E +V+ A E +Q +Q+++ E H ISS
Sbjct: 675 RAQEKVHE--MEKEHLNKVQTANEV--KQAVEQQIQSHRE-------THQKQISS----- 718
Query: 651 ILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVA------ELVY 699
R E+E A+ I D+ + +E R ++ E++ A ++
Sbjct: 719 ------------LRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLH 766
Query: 700 SFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQ------KKLTEGEQDEASNA 753
+ + ++ ++ ++ + + + Q +H+ + VQ KK E + D+ +
Sbjct: 767 ELTVMQDRREQARQDLKGLE-ETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGS 825
Query: 754 AMLLEKETQNENN 766
A +K + ENN
Sbjct: 826 AAQKQKISFLENN 838
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 48.1 bits (113), Expect = 3e-05
Identities = 119/550 (21%), Positives = 216/550 (39%), Gaps = 99/550 (18%)
Query: 259 DTSQFEKRRKMMNEME--RKEWAFREQEIEKLQEIRLEVLKELLRKREE-NQNEV----N 311
D +Q ++ ++ E+E R++ RE E+ LQ+ + +E R +E+ + EV N
Sbjct: 1003 DRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQN 1062
Query: 312 MKHLNARWSKLQEG--KEAKMAKIQRTHVS----TIRKLVGKRKNIEGKLERRNIIKDYS 365
L A + +LQE ++ ++ + Q +S +++L +R EGK+ + ++K
Sbjct: 1063 DPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEK 1122
Query: 366 DYASQ-VYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRA---P 421
D A++ L+R + D ++ + + LE V Q ++R P
Sbjct: 1123 DAATEREVSDLTRQ--YEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRP 1180
Query: 422 KPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPT 481
PK + A L EL E + + ++ + L+R PQ + T
Sbjct: 1181 DPKAES-------EVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRG-PQVEVKEVT 1232
Query: 482 LEMTSNEEE-EMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVK 540
E+ + + EME LQ+L V + + E + LE+ Q + AL++ + V+
Sbjct: 1233 KEVIKYKTDPEMEKE---LQRLREEIVDKTRLIERCD--LEIYQLKKEIQALKDTKPQVQ 1287
Query: 541 KAEK-QVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAF 599
E Q L Q E SL RA
Sbjct: 1288 TKEVVQEILQFQEDPQTKEEVASL----------RA------------------------ 1313
Query: 600 VMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTA 659
L+E Q++ + E R E+Q R+E+E+ + +V + Y E+ L EA+
Sbjct: 1314 -KLSEEQKKQVDLERE-RASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAF 1371
Query: 660 EE----------QARAEIEKMAEKINDIAYEME----SRRTYLQSEEIVAELVYSFLIPE 705
E + RAE+ ++ + ++ ++E R+ ++E V L E
Sbjct: 1372 AESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALE 1431
Query: 706 VQKYFVKEKVRNAQ-----------RKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAA 754
++ +EKV + Q R+H L Q+ E +++L EGE +
Sbjct: 1432 QEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQL----EEEQHRRQLLEGELETLRRKL 1487
Query: 755 MLLEKETQNE 764
LEK E
Sbjct: 1488 AALEKAEVKE 1497
Score = 45.4 bits (106), Expect = 2e-04
Identities = 69/282 (24%), Positives = 125/282 (44%), Gaps = 44/282 (15%)
Query: 489 EEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTL 548
+EE+E + L+ L Q G+E ++ + + A Q DE L + E +
Sbjct: 968 QEELEALQLQLRAL-----EQETRDGGQEYVVKEVLRIEPDRA-QADEVLQLREELE--- 1018
Query: 549 ALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA-FVMLAE--- 604
AL+RQ+ E +V L++ +A L KE+V+LQ + ++ A + L E
Sbjct: 1019 ALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQ 1078
Query: 605 RQRRVREAEE-------SGRRQVEKQRLREEDEI-FKEVVKVHHSTISSYLEDIILNTEA 656
RQ ++RE +E +++EK+R E +I KEV+KV E
Sbjct: 1079 RQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKV----------------EK 1122
Query: 657 NTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVR 716
+ A E+ E+ + + D A ++R + + E++ ++ L E K V+EKVR
Sbjct: 1123 DAATER---EVSDLTRQYEDEA--AKARASQREKTELLRKI--WALEEENAKVVVQEKVR 1175
Query: 717 NAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLE 758
R A ++ + E + Q++ G +++ + LE
Sbjct: 1176 EIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELE 1217
>gi|222537714 taxilin beta [Homo sapiens]
Length = 684
Score = 47.8 bits (112), Expect = 4e-05
Identities = 55/235 (23%), Positives = 101/235 (42%), Gaps = 18/235 (7%)
Query: 535 DEKLVKKAEKQVTLALQRQRNLH--EHKVSLVENHLAGL--EGRALADMFDFLSKELVRL 590
++K++K K+ L +Q L E K + A L E R L K+ V++
Sbjct: 134 EKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQI 193
Query: 591 QEER------RIHAFVMLAERQRRVREAEESGRRQVEK--QRLREEDEIFKEVVKVHHST 642
Q+E+ A + ++ + RE + + E+ QR REE+E KE+ ST
Sbjct: 194 QKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQST 253
Query: 643 ISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFL 702
++ I +E N Q E +AEK+ I + E R +L EL +
Sbjct: 254 LTDIQGQIEQQSERNMKLCQENTE---LAEKLKSIIDQYELREEHLDKIFKHRELQQKLV 310
Query: 703 IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
++++ +E ++ A+ +H +++ E +Q K+ + EQ+ A + L
Sbjct: 311 DAKLEQ--AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLK-EQETVLQAQLTL 362
Score = 34.3 bits (77), Expect = 0.45
Identities = 49/206 (23%), Positives = 92/206 (44%), Gaps = 32/206 (15%)
Query: 259 DTSQFEKRRKMMNEMERKEW----AFREQEIE-KLQEIRLEVLKELLRKREENQNEVNMK 313
+T EK + ++++ E +E F+ +E++ KL + +LE +E++++ EE
Sbjct: 275 NTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEY 334
Query: 314 HLN--ARWSKLQEGKEAKMAKIQRTHVSTIRKLV-GKRKNIEGKLERRNIIKDYSDYASQ 370
LN A W KLQ AK+ K Q T + L G+ + + L + N + ++ + +
Sbjct: 335 LLNQAAEW-KLQ----AKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEV--FATFKQE 387
Query: 371 VYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC---LPDFVTQPQIRAPKPKVIT 427
+ D ++ +K +T E+C L D + + +RA + +
Sbjct: 388 M-----------DKTTKK--MKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFV 434
Query: 428 TKAGFLKRAAR-LDYELAEVHKALLD 452
K G L+ R L E E+HK + D
Sbjct: 435 MKIGRLENLCRALQEERNELHKKIRD 460
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 47.8 bits (112), Expect = 4e-05
Identities = 112/561 (19%), Positives = 222/561 (39%), Gaps = 77/561 (13%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRR------KMMNEMERKEWAFREQEIEKL 288
+A+ ++ +R +E ++ A + + K+R +M ++ER A ++K
Sbjct: 1391 EAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAA--LDKK 1448
Query: 289 QEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKR 348
Q +VL E +K EE Q E+ +R ++ K++ + ++ +L R
Sbjct: 1449 QRNFDKVLSEWKQKYEETQAELEASQKESR------SLSTELFKVKNVYEESLDQLETLR 1502
Query: 349 KNIEGKLERRNIIKDYSDYASQVYG---PLSRLGCFPDNNSEDFVVKNYYLNTYEGLVEL 405
+ E +N+ ++ SD Q+ + L ++ L E +E
Sbjct: 1503 R------ENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEH 1556
Query: 406 ES--CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLD----KKNKVLE 459
E L + Q+++ + I K + + R + E ++ LD +N L
Sbjct: 1557 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR 1616
Query: 460 VKKPPRF------LQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMF 513
VKK +Q N RL +L N + ++ ++L LRG+
Sbjct: 1617 VKKKMEGDLNEMEIQLNHAN--RLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQL 1674
Query: 514 EGKEKRLELIQ-ELRTCHA-LQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGL 571
E+R L+Q E+ A L++ E+ K AE+++ A +R + LH SL+
Sbjct: 1675 AIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK-- 1732
Query: 572 EGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEI 631
L ++ +LQ E + E + R AEE ++ + + E+
Sbjct: 1733 -----------LENDVSQLQSE--------VEEVIQESRNAEEKAKKAITDAAMMAEELK 1773
Query: 632 FKEVVKVHHSTISSYLEDII--LNTEANTAEEQA----RAEIEKMAEKINDIAYEMESRR 685
++ H + LE + L + AE+ A + +I+K+ ++ ++ E+E+ +
Sbjct: 1774 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQ 1833
Query: 686 TYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQ--RKHILAAHQIIHSYTESMVQKKLT 743
++ E V L + VKE + RK++L ++ + K
Sbjct: 1834 K--RNAEAVKGL-------RKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQ 1884
Query: 744 EGEQDEASNAAMLLEKETQNE 764
E +E SNA + ++ Q+E
Sbjct: 1885 AEEAEEQSNANLSKFRKLQHE 1905
Score = 34.7 bits (78), Expect = 0.34
Identities = 93/482 (19%), Positives = 191/482 (39%), Gaps = 87/482 (18%)
Query: 231 LPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKE------------W 278
L + + E EM E + + L A S+ + E KM+ ++ K
Sbjct: 843 LKSAETEKEMATMKEEFQKTKDEL-AKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901
Query: 279 AFREQEIEKL--QEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT 336
A E+ E+L +I+LE + + +R E + E+N + L A+ KL++ I
Sbjct: 902 ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE-LTAKKRKLEDECSELKKDIDDL 960
Query: 337 HVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYL 396
+ T+ K+ ++ E K +K+ ++ + + +++L + E ++ +
Sbjct: 961 EL-TLAKVEKEKHATENK------VKNLTEEMAGLDETIAKL------SKEKKALQETHQ 1007
Query: 397 NTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNK 456
T + L Q K ++T K +L+ ++ ++ +L +K
Sbjct: 1008 QTLDDL--------------QAEEDKVNILT------KAKTKLEQQVDDLEGSLEQEKKL 1047
Query: 457 VLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEE------EEMEMAVIYLQKLLRGRVVQN 510
+++++ R L+ + T++M ++++ E+ E + L +
Sbjct: 1048 RMDLERAKRKLEGD---LKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVE 1104
Query: 511 MMFEGKEKRLEL-IQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLA 569
+ + K K L+ I+EL ++ + KAEKQ + R L E L E
Sbjct: 1105 IQLQKKIKELQARIEELG--EEIEAERASRAKAEKQRS---DLSRELEEISERLEE---- 1155
Query: 570 GLEGRALADMFDFLSKELVRLQEERRI-------HAFVMLAERQRRVREAEESGRRQVEK 622
G A + + K Q+ RR H ++ A R++ E G +
Sbjct: 1156 --AGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213
Query: 623 QRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEME 682
QR++++ E K +K+ +SS E I +A+ +EKM + D E++
Sbjct: 1214 QRVKQKLEKEKSELKMETDDLSSNAEAI----------SKAKGNLEKMCRSLEDQVSELK 1263
Query: 683 SR 684
++
Sbjct: 1264 TK 1265
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 47.0 bits (110), Expect = 7e-05
Identities = 107/530 (20%), Positives = 216/530 (40%), Gaps = 69/530 (13%)
Query: 237 EVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVL 296
E+E +E E+ +W+ + E+++K+ E E W ++E +E +L
Sbjct: 1717 ELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAW---QREKLSEEETKLAQE 1773
Query: 297 KELLRKREEN--QNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
+ELL + +E Q++ M R + +E K K+ + I + KN
Sbjct: 1774 EELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMIL 1833
Query: 355 LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVT 414
+++N+ ++ + A + R K L E L +
Sbjct: 1834 YQKKNLAQEKKNLAQEKEKLAQR--------------KENLLYNKERLTH---------S 1870
Query: 415 QPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEV-KKPPRFLQRNPIP 473
+ Q+ K K+ F K A+++ +L + + ++ KK K+ E KK +
Sbjct: 1871 KKQLVQVKNKL----GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK 1926
Query: 474 QPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQ 533
Q +L +++ +E A++ +K LRG + ++ E K LE+ + L
Sbjct: 1927 QEKLAQEKMKLA------LEKAMVQGKKRLRGEL--DIAKEEKALNLEMKRLAEEKMRLV 1978
Query: 534 EDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEE 593
E ++ + K E T RQR + + + L E L+ LE + L L ++ + EE
Sbjct: 1979 EGKETLSKGETPET---SRQRKMTQVEQELFERKLS-LEEKIL------LHEDRILAMEE 2028
Query: 594 RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILN 653
I + R +R+ + + ++ +++ + + KE K L I+
Sbjct: 2029 SEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAK---------LNKILKA 2079
Query: 654 TEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKE 713
+ T +E+ + E K+ + E R + QS+ + E +S E+ K ++
Sbjct: 2080 LQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTK--DEK 2137
Query: 714 KVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEA-SNAAMLLEKETQ 762
K+ QRK ++I+ ++K+TE E A ++ ++L+ E +
Sbjct: 2138 KLARKQRKLANKMRRMINK------EEKMTEEESKLARKHSEVILDDEEE 2181
Score = 43.9 bits (102), Expect = 6e-04
Identities = 63/323 (19%), Positives = 136/323 (42%), Gaps = 43/323 (13%)
Query: 434 KRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEE-- 491
K+ AR +LA + +++K+ K+ E + +L E+ ++EEE
Sbjct: 2137 KKLARKQRKLANKMRRMINKEEKMTE-------------EESKLARKHSEVILDDEEEGG 2183
Query: 492 --MEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTC-HALQEDEKLVKKAEKQVTL 548
E + +L++ R R + KEK + E+ + H +E E L+ + EKQ +L
Sbjct: 2184 IEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESL 2243
Query: 549 ALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRR 608
+ + + E + +E VR +EE R ++ +
Sbjct: 2244 SSEEEEEREEEEER---------------------EEEEVREEEEERKEEEEGEEKQVEK 2282
Query: 609 VREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIE 668
E ++ +++ +K+ ++E++E+F+E ++ + L D E+ + EE+ E +
Sbjct: 2283 EEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDRE-K 2341
Query: 669 KMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQ 728
++ +K + E RR L+ E V ++ +P + ++ V + K +++
Sbjct: 2342 EILKKEKQFKLQ-EQRRKSLRGRERVLSILRG--VPHGKGRAIRLGVLKSPLKKLMSTAL 2398
Query: 729 IIHSYTESMVQKKLTEGEQDEAS 751
+ T V +K E +A+
Sbjct: 2399 EMKEKTPVPVPEKQISWEDKKAT 2421
Score = 35.4 bits (80), Expect = 0.20
Identities = 67/268 (25%), Positives = 111/268 (41%), Gaps = 45/268 (16%)
Query: 532 LQEDEKLVKKAEKQV-----TLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKE 586
LQED+KL + KQV + + Q+ E +V+L E EG +++E
Sbjct: 1510 LQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEE--VSREGEEKEQQ---VTEE 1564
Query: 587 LVRLQEER---RIHAFVMLAERQRRVRE----AEESGRRQVEKQRLREEDEIFKEVVKV- 638
+QEE RIH AE++R E EE Q E+Q +EE ++ + VK+
Sbjct: 1565 QRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKIT 1624
Query: 639 HHSTISSYLEDIILNTEANTAE--EQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAE 696
+ E E A+ E+ E EK+A+K +A + E + EE +A+
Sbjct: 1625 QDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEK---VAREEEKLAK 1681
Query: 697 L------VYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESM------------- 737
V + L +V++ +E+ + Q K + + + E +
Sbjct: 1682 KGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGK 1741
Query: 738 ---VQKKLTEGEQDEASNAAMLLEKETQ 762
+KKL E E+ A L E+ET+
Sbjct: 1742 LVEEKKKLAEEEEALAWQREKLSEEETK 1769
Score = 31.6 bits (70), Expect = 2.9
Identities = 29/129 (22%), Positives = 54/129 (41%), Gaps = 12/129 (9%)
Query: 247 KRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFRE-----QEIEKLQEIRLEVLKELLR 301
KR W A EK ++E+E +E E E+EK + + E +E R
Sbjct: 2194 KRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEE--R 2251
Query: 302 KREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNII 361
+ EE + E ++ + +EG+E ++ K + +K K K E E+ +
Sbjct: 2252 EEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEE-----KKKKKKEKKKEEVQEKEEVF 2306
Query: 362 KDYSDYASQ 370
++ + S+
Sbjct: 2307 EEKEEIMSE 2315
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1201 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1260
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1261 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1320
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1321 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1368
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1427 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1477
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1536
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1537 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1645
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1706 QQRLAAEQELIRLRAETE 1723
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2252 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2305
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2423
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2424 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2482
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2531
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2532 EEQQRQQ 2538
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1795 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1853 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2085 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2138
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2139 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2197 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2240
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2495
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2542
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2585
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2586 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2620
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1365 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1477
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1519
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1520 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1562 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1847 RLKTEAEIALKEKEAENE 1864
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1761 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1807
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1808 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 1864
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 1914
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 1915 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 2027 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2143
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEK 2169
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1205 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1264
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1265 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1324
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1325 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1372
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1431 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1481
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1540
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1541 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1595
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1596 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1649
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1709
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1710 QQRLAAEQELIRLRAETE 1727
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2255
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2256 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2309
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2310 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2369
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2427
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2428 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2486
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2487 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2535
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2536 EEQQRQQ 2542
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1799 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1857 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1968
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2028
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2089 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2142
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2143 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2201 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2244
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2499
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2546
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2589
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2590 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2624
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1369 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1427
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1481
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1523
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1524 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1566 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1851 RLKTEAEIALKEKEAENE 1868
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1765 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1811
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1812 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 1868
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 1869 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 1918
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 1919 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 2031 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2089
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2147
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEK 2173
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1201 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1260
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1261 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1320
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1321 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1368
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1427 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1477
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1536
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1537 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1645
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1706 QQRLAAEQELIRLRAETE 1723
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2252 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2305
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2423
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2424 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2482
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2531
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2532 EEQQRQQ 2538
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1795 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1853 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2085 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2138
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2139 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2197 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2240
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2495
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2542
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2585
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2586 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2620
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1365 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1477
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1519
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1520 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1562 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1847 RLKTEAEIALKEKEAENE 1864
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1761 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1807
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1808 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 1864
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 1914
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 1915 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 2027 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2143
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEK 2169
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1169 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1228
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1229 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1288
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1289 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1336
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1394
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1395 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1445
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1504
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1505 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1559
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1560 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1613
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1673
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1674 QQRLAAEQELIRLRAETE 1691
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2219
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2220 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2273
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2274 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2333
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2391
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2392 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2450
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2451 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2499
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2500 EEQQRQQ 2506
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1763 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1821 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1932
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 1992
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2053 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2106
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2107 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2165 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2208
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2463
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2510
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2553
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2554 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2588
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1333 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1391
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1445
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1487
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1488 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1530 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1815 RLKTEAEIALKEKEAENE 1832
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1729 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1775
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1776 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 1832
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 1833 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 1882
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 1883 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 1995 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2053
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2111
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEMEK 2137
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1338 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1397
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1398 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1457
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1458 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1505
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1564 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1614
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1673
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1674 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1728
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1729 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1782
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1842
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1843 QQRLAAEQELIRLRAETE 1860
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2389 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2442
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2443 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2502
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2560
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2561 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2619
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2620 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2668
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2669 EEQQRQQ 2675
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1932 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1990 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 2101
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2161
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2222 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2275
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2276 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2334 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2377
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2632
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2679
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2722
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2723 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2757
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1502 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1614
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1656
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1657 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1699 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1984 RLKTEAEIALKEKEAENE 2001
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1898 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1944
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1945 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 2001
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 2002 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 2051
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 2052 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 2164 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2222
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2280
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEK 2306
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1179 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1238
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1239 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1298
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1299 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1346
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1404
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1405 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1455
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1514
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1515 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1569
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1570 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1623
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1683
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1684 QQRLAAEQELIRLRAETE 1701
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2229
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2230 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2283
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2284 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2343
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2401
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2402 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2460
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2509
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2510 EEQQRQQ 2516
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1773 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1831 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 1883 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1942
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2002
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2063 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2116
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2117 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2175 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2218
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2473
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2520
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2563
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2564 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2598
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1343 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1401
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1455
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1497
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1498 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1540 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1825 RLKTEAEIALKEKEAENE 1842
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1739 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1785
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1786 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 1842
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 1843 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 1892
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 1893 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 2005 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2063
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2121
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEMEK 2147
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1187 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1246
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1247 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1306
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1307 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1354
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1355 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1412
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1413 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1463
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1522
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1523 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1577
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1578 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1631
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1691
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1692 QQRLAAEQELIRLRAETE 1709
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2237
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2238 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2291
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2292 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2351
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2409
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2410 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2468
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2469 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2517
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2518 EEQQRQQ 2524
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1781 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1839 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1950
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2010
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2071 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2124
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2125 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2183 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2226
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2481
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2528
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2571
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2572 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2606
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1351 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1409
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1463
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1505
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1506 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1548 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1592
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1833 RLKTEAEIALKEKEAENE 1850
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1747 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1793
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1794 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 1850
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 1851 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 1900
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 1901 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 2013 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2071
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2129
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2130 QEAARRAQAEQAALRQKQAADAEMEK 2155
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 46.6 bits (109), Expect = 9e-05
Identities = 111/558 (19%), Positives = 215/558 (38%), Gaps = 69/558 (12%)
Query: 239 EMIERAREKRAWEASLPALSDTSQFEKRRK-------MMNEMERKEWAFREQEIEKLQEI 291
E+ + R+ R + S L Q +RR+ + + +E +EQ + + E
Sbjct: 1228 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1287
Query: 292 RLEVLKELLRKREENQNEVNMKHLNARWSKLQ---EGKEAKMAKIQRTHVSTIRKLVGKR 348
E ++E R ++ N + L K Q AK K+Q S I++ V R
Sbjct: 1288 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1347
Query: 349 KNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESC 408
+ E + Y + S+ L R+ E+ + + E L E+E+
Sbjct: 1348 THYS---ELTTLTSQYIKFISET---LRRM------EEEERLAEQQRAEERERLAEVEAA 1395
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L + A +A L++ R+ E+ +A +D + + +++ + L+
Sbjct: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1453
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRT 528
++ + ++ + + E E + + +++ +R VV+ + + +R EL+
Sbjct: 1454 QSSEAE-------IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQA 1504
Query: 529 CHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELV 588
A E+ + K+ ++ L+RQ + E LA +A A+ + L
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQ 1563
Query: 589 RLQEERRIHAFVMLAERQRRVREAEESGRRQVE-----------------KQRLREEDEI 631
L+E R + E +RR+R+AE RQV+ + E+
Sbjct: 1564 ALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1618
Query: 632 FKEVVKVHHSTISSYLED----IILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTY 687
+ ++ H ++ E+ EA A E+A E+E+ K N E+ R
Sbjct: 1619 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------EALRLR 1672
Query: 688 LQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQ 747
LQ+EE+ + + E QK + + R + A Q + E Q++L EG
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1732
Query: 748 DE---ASNAAMLLEKETQ 762
+ A + L ET+
Sbjct: 1733 QQRLAAEQELIRLRAETE 1750
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/367 (22%), Positives = 149/367 (40%), Gaps = 60/367 (16%)
Query: 438 RLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQP----RLPTPTLEMTSNEEEEME 493
RL E + K LLD++ + L+ + QR+ + + R+ L E
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 494 MAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQR 552
A+I K R +Q E EK ++ +E R A QE +L + AE+ LA QR
Sbjct: 2279 RALILRDKDNTQRFLQ----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--LAQQR 2332
Query: 553 ---QRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHA----------- 598
++ L E ++ E E L + ++ RLQE++ A
Sbjct: 2333 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2392
Query: 599 FVMLAERQRRVREAEES--------------GRRQVEKQRLREEDEIFKEVVKVHHSTIS 644
+ AERQR++ + E+ R + + QR R++ E E K+H + ++
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELA 2450
Query: 645 SYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYE-----MESRRTYLQSEEIVAELVY 699
+ E + L +Q+ + E++ E I ++ E E++ L+SEE+
Sbjct: 2451 TQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2509
Query: 700 SFL--IPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLL 757
L +Q+ F+ EK QR+ + + KL + QDE + A L
Sbjct: 2510 QLLQETQALQQSFLSEKDSLLQRERFI-----------EQEKAKLEQLFQDEVAKAQQLR 2558
Query: 758 EKETQNE 764
E++ + +
Sbjct: 2559 EEQQRQQ 2565
Score = 40.0 bits (92), Expect = 0.008
Identities = 97/470 (20%), Positives = 195/470 (41%), Gaps = 43/470 (9%)
Query: 243 RAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEI-EKLQEI----RLEVLK 297
R RE A L AL++ ++ ++R++ E ++ A E+ + EKL I RL+
Sbjct: 1822 RFRELAEEAARLRALAEEAK--RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879
Query: 298 ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRT---HVSTIR-KLVGKRKNIEG 353
E+ K +E +NE R +L E + + +++ H + I +L RK +
Sbjct: 1880 EIALKEKEAENE--------RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931
Query: 354 KLER-RNIIKDYSDYASQVYGPLSRLGCFPDNNSE-----DFVVKNYYLNTYEGLVELES 407
+LER + +++D QV + L + + + + N + L E
Sbjct: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1991
Query: 408 CLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDK----KNKVLEVKKP 463
+ Q Q+ A + + ++++ + E A KA L++ K KV E ++
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2051
Query: 464 PRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI 523
++ Q +L + EE+ + ++ + +Q + R E
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111
Query: 524 QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
R A +E E+ +AE++ + ++ K S E A + +A A+ L
Sbjct: 2112 AARR---AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---L 2165
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTI 643
KE QE R A RQ++ +AE ++ +Q LR++ ++ +E+ +
Sbjct: 2166 RKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223
Query: 644 SSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEI 693
+ + +L+ E ++ +AE + A + + + E+ S R +Q EE+
Sbjct: 2224 ETDHQKNLLDEEL----QRLKAEATEAARQRSQVEEELFSVR--VQMEEL 2267
Score = 38.1 bits (87), Expect = 0.031
Identities = 45/217 (20%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 483 EMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKA 542
+ + ++ E + A+ L++ + + + K + ++ +Q+ + LQE + L +
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---LQETQALQQSF 2522
Query: 543 EKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVML 602
+ LQR+R + + K L + +F + +L+EE++ M
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQ-------------LFQDEVAKAQQLREEQQRQQQQME 2569
Query: 603 AERQRRVREAEESGRRQVE-KQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE 661
ERQR V EE+ RRQ E ++ +R + E ++ L + EE
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----------------LEQQRRQQEE 2612
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELV 698
E +++ E++ E + R SEE+ A V
Sbjct: 2613 LLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2647
Score = 34.7 bits (78), Expect = 0.34
Identities = 112/558 (20%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 241 IERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELL 300
+E A EK+ A A + +Q E+ K + + ++E RE+ Q+ + + +EL
Sbjct: 1392 VEAALEKQRQLAEAHAQAK-AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1450
Query: 301 RKREENQNEVNMKHLNARW---SKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLER 357
+ R+ ++ E+ K A S+L+ +E ++ ++Q + +R EG+L+
Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ------LEATERQRGGAEGELQA 1504
Query: 358 -RNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQP 416
R ++ Q RL + S+ + VEL S
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQAEVELAS--------- 1546
Query: 417 QIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPR 476
+++A AAR E +AL + L+ ++ R L++ + + R
Sbjct: 1547 RVKAEA------------EAAR------EKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 477 LPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHAL--QE 534
LE T+ E E+ Q+ EK +L + L+ H Q
Sbjct: 1589 QVQVALE-TAQRSAEAEL--------------QSKRASFAEKTAQLERSLQEEHVAVAQL 1633
Query: 535 DEKLVKKAEKQVTLALQRQ---RNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQ 591
E+ ++A++Q R+ R L ++ E L+ +A E + +
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 592 EE-----RRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSY 646
EE RR A RQR + E E +RQ+ + ++ +E++++ T
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 647 LEDIILNTEANTAEEQARAEIEKMAEKINDIA---------------YEMESRRTYLQSE 691
+ +L E + +A A +K E ++A E ESR T +S+
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 692 EIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTES---MVQKKLTEGEQD 748
+ + F + ++ A+R+ LA E+ + +K GE
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 749 EASNAA--MLLEKETQNE 764
A L EKE +NE
Sbjct: 1874 RLKTEAEIALKEKEAENE 1891
Score = 33.5 bits (75), Expect = 0.76
Identities = 96/446 (21%), Positives = 173/446 (38%), Gaps = 80/446 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+AE+E++ A + RA E S TS+ K+R +E + FRE E RL
Sbjct: 1788 RAEMEVL-LASKARAEEES----RSTSEKSKQR-----LEAEAGRFRELAEEAA---RLR 1834
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGK 354
L E KR+ E + A ++ K A + + T + T ++ K K E +
Sbjct: 1835 ALAEEA-KRQRQLAEEDAARQRAEAERVLAEKLAAIG--EATRLKTEAEIALKEKEAENE 1891
Query: 355 ----------LERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVE 404
+RR + + + + + + L++L D+ L +GLVE
Sbjct: 1892 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----------LERQKGLVE 1941
Query: 405 LESCLPDFVTQPQIRAPKPKVITTKAGFLKRAA---RLDYELAEVHK----ALLDKKNKV 457
T Q R + +++ KA F K AA L+ EL + L K+
Sbjct: 1942 --------DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 458 LEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLR-------GRVVQN 510
LE + + + + + EEE L+++ R R ++
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 511 MMFEGKEKRLELIQELRTCHALQEDEKL----VKKAEKQVTLALQRQRNL---------- 556
+ ++L+L QE LQ +EK V++ E+++ LQ+++++
Sbjct: 2054 RAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2112
Query: 557 -----HEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVRE 611
E + + V+ + R + + L K+ Q + R A AE+ R+ E
Sbjct: 2113 ARRAAEEAEEARVQAEREAAQSRRQVEEAERL-KQSAEEQAQARAQAQAA-AEKLRKEAE 2170
Query: 612 AEESGRRQVEKQRLREEDEIFKEVVK 637
E + R Q E+ LR++ E+ K
Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEMEK 2196
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 46.6 bits (109), Expect = 9e-05
Identities = 108/493 (21%), Positives = 210/493 (42%), Gaps = 65/493 (13%)
Query: 235 QAEVEMIERA-REKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRL 293
+A VE + A RE+R WE L S+ + R + E E + Q +E+ + R
Sbjct: 812 EALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGR------QHLEEAERERR 865
Query: 294 EVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHV-----STIRKLVGKR 348
E KE L + E + V K L AR LQ +E + A ++R S ++ G
Sbjct: 866 E--KEAL-QAELEKAVVRGKELGARLEHLQ--RELEQAALERQEFLREKESQHQRYQGLE 920
Query: 349 KNIEGKLE-----RRNIIKDYSDYASQVYGPLSRL-----GCFPDNNSEDFVVKNYYLNT 398
+ +E +L+ + + + A Q+ L +L G P +E +V+ +
Sbjct: 921 QRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVR- 979
Query: 399 YEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAAR---LDYELAEVHKALLDKKN 455
L+E+E V + + + + + G L+ A+ L + A+ H + L +
Sbjct: 980 ---LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEK 1036
Query: 456 KVLEVKKPPRFLQRNPIPQP-RLPTPTLEMTSNEEEEM---EMAVIYLQKL----LRGRV 507
VLE++ + + + R + E T +++ + A+ LQ+ L G +
Sbjct: 1037 SVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLL 1096
Query: 508 VQNMMFEGKEKRLELI-QELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHE-HKVSLVE 565
V++ + + LEL +EL+ H + ++ +A+ +V L +R+R + + H+ +E
Sbjct: 1097 VRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLE 1155
Query: 566 NHLAGLEGR--ALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQ 623
L L+ + LS+E LQ ER R R R E + +++ Q
Sbjct: 1156 EELRRLQSEHDRAQMLLAELSRERGELQGERG-------ELRGRLARLELERAQLEMQSQ 1208
Query: 624 RLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEE----QARAEIEKMAEKINDIAY 679
+LRE + + + + +++ E L T+ +A+E Q AE++ ++ + ++
Sbjct: 1209 QLRESN----QQLDLSACRLTTQCE---LLTQLRSAQEEENRQLLAEVQALSRENRELLE 1261
Query: 680 EMESRRTYLQSEE 692
R +L E+
Sbjct: 1262 RSLESRDHLHREQ 1274
Score = 41.6 bits (96), Expect = 0.003
Identities = 74/320 (23%), Positives = 127/320 (39%), Gaps = 60/320 (18%)
Query: 489 EEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRL------------ELIQELRTCHALQEDE 536
+ E+E A + Q+ LR + Q+ ++G E+RL E + EL+T ALQ +E
Sbjct: 892 QRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKT-RALQLEE 950
Query: 537 KLVKKAEKQVTLALQRQRN---LHEHKVSLVE----NHLAGLEGRALADMFDFLSKELVR 589
+L + + L +++ + V L+E N + E AL L +L
Sbjct: 951 ELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGS 1010
Query: 590 LQEERRIHAFVMLAERQRRVREAEESGRRQVEK-------QRLREEDEIFKEVVKVHHST 642
LQ A +L + Q R E S R Q EK Q L + E+ +E V+ +
Sbjct: 1011 LQG----RAQELLLQSQ---RAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQS 1063
Query: 643 ISSY--LEDIILNTEANTAEEQAR--AEIEKMAEKINDIA----------YEMESRRTYL 688
+ +L A+ Q R AE+E + + D+ E++ R L
Sbjct: 1064 QEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQL 1123
Query: 689 QSEEIVAELVYSFLIPEVQKYF--------VKEKVRNAQRKHILAAHQIIHSYTESMVQK 740
Q++ E L+ E ++ ++E++R Q +H A + E ++
Sbjct: 1124 QAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLL----AELSRER 1179
Query: 741 KLTEGEQDEASNAAMLLEKE 760
+GE+ E LE E
Sbjct: 1180 GELQGERGELRGRLARLELE 1199
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 46.2 bits (108), Expect = 1e-04
Identities = 61/268 (22%), Positives = 121/268 (45%), Gaps = 29/268 (10%)
Query: 484 MTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAE 543
M EE+ + +K + R + MM+E +EK EL +++ ++E E +K +
Sbjct: 358 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE---EKRQ 414
Query: 544 KQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLA 603
++ + Q +R E K+ E + E + +E ++E +IH +
Sbjct: 415 EEEKIREQEKRQEQEAKMWRQEEKIREQEEK-------IREQEKKMWRQEEKIHEQEKIR 467
Query: 604 ERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANT--AEE 661
E ++R +E EE R +++++ E++EI+++ K+H E+ I E EE
Sbjct: 468 EEEKR-QEQEEMWR---QEEKIHEQEEIWRQKEKMHEQ------EEKIRKQEEKVWRQEE 517
Query: 662 QARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRK 721
+ R + EK+ E+ + + E R + EE+ E + E +K + +EK R Q
Sbjct: 518 KIREQEEKIREQEEKMWRQEEKIR---EQEEMWRE---EEKMHEQEKIWEEEK-RQEQED 570
Query: 722 HILAAHQIIHSYTESMVQKKLTEGEQDE 749
+ + I E + +++ EQ+E
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEE 598
Score = 44.7 bits (104), Expect = 3e-04
Identities = 49/234 (20%), Positives = 100/234 (42%), Gaps = 35/234 (14%)
Query: 516 KEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRA 575
+E+++ +++R QE E++ ++ EK + Q + K + E
Sbjct: 456 QEEKIHEQEKIREEEKRQEQEEMWRQEEK-----IHEQEEIWRQKEKMHEQ--------- 501
Query: 576 LADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEV 635
+E +R QEE+ + E++ ++RE EE RQ EK +RE++E+++E
Sbjct: 502 ---------EEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK--IREQEEMWREE 550
Query: 636 VKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVA 695
K+H E I + E++ + EK+ E+ + + E R + +
Sbjct: 551 EKMHEQ------EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQE 604
Query: 696 ELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDE 749
E ++ + +K +E+ Q + I + I E +++ GEQ+E
Sbjct: 605 EKMWK----QEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 654
Score = 41.6 bits (96), Expect = 0.003
Identities = 54/237 (22%), Positives = 103/237 (43%), Gaps = 34/237 (14%)
Query: 489 EEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELI------QELRTCHA-LQEDEKLVKK 541
E E ++ + QK R ++ + E LEL +EL+ +A LQE +LV+
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 235
Query: 542 AEKQVTLALQR-QRNLHEHKVSLVENHL-------------------AGLEGRALADMFD 581
+ ++ L ++ +R L K+ L + L A +E L + +
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 295
Query: 582 FLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHS 641
+E + QEE+ + E++ ++RE EE R Q EK R R+E+ ++++ K+
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR-RQEEMMWEKEEKMRRQ 354
Query: 642 TISSYLEDIILNTEAN---TAEEQARAEIEKM---AEKINDIAYEMESRRTYLQSEE 692
+ ++ + + EE+ R + E M EKI ++ +M + + EE
Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 411
Score = 38.9 bits (89), Expect = 0.018
Identities = 58/261 (22%), Positives = 115/261 (44%), Gaps = 51/261 (19%)
Query: 509 QNMMFEGKEK--RLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVEN 566
+ MM+E +EK R E + + +++E + +K EK ++RQ + K E
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK-----MRRQEEMMWEK----EE 391
Query: 567 HLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLR 626
+ LE + +E +R QEE+R + + ++RE E+ R++ E + R
Sbjct: 392 KIRELEEK-------MHEQEKIREQEEKR--------QEEEKIREQEK--RQEQEAKMWR 434
Query: 627 EEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKM---AEKINDIAYEMES 683
+E++I ++ K+ + ++ ++ + EE+ R E E+M EKI++
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ 494
Query: 684 RRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLT 743
+ + EE + + E + + +EK+R + K I E M +++
Sbjct: 495 KEKMHEQEEKIRK-------QEEKVWRQEEKIREQEEK--------IREQEEKMWRQEEK 539
Query: 744 EGEQDEASNAAMLLEKETQNE 764
EQ+E M E+E +E
Sbjct: 540 IREQEE-----MWREEEKMHE 555
Score = 37.0 bits (84), Expect = 0.069
Identities = 84/416 (20%), Positives = 163/416 (39%), Gaps = 70/416 (16%)
Query: 229 RGLPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKL 288
R L E E I EKR E + + EKR++ +M R+E REQE EK+
Sbjct: 394 RELEEKMHEQEKIREQEEKRQEEEKI------REQEKRQEQEAKMWRQEEKIREQE-EKI 446
Query: 289 --QEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVG 346
QE ++ +E + ++E+ + E + W QE K + +I R +
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR--QEEKIHEQEEIWRQKEKMHEQEEK 504
Query: 347 KRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELE 406
RK E + I++ + + + R E + E + E E
Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMWR-------QEEKIREQEEMWREEEKMHEQE 557
Query: 407 SCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRF 466
+ Q Q + R + ++ E + + ++ K+ E ++ +
Sbjct: 558 KIWEEEKRQEQE---------------DKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 467 LQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQEL 526
+ Q E +EE++ ++ + R + M E +EK E QE
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIR------EQEEKIREQEEMTQEQEEKMGE--QEE 654
Query: 527 RTCHA---LQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFL 583
+ C +QE E+ + + E+++ ++++ + E + + E
Sbjct: 655 KMCEQEEKMQEQEETMWRQEEKIR---EQEKKIREQEEKIREQ----------------- 694
Query: 584 SKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQ-----RLREEDEIFKE 634
+E+++ QEE+ + E++ +++E EE RRQ EK RLR+++E +E
Sbjct: 695 -EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 30.8 bits (68), Expect = 4.9
Identities = 21/79 (26%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 237 EVEMIERAREKRAWEAS--LPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
E E R +E+ WE + L + +++ + E ++E REQE + QE ++
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 433
Query: 295 VLKELLRKREENQNEVNMK 313
+E +R++EE E K
Sbjct: 434 RQEEKIREQEEKIREQEKK 452
Score = 30.4 bits (67), Expect = 6.5
Identities = 42/175 (24%), Positives = 76/175 (43%), Gaps = 14/175 (8%)
Query: 516 KEKRLELIQEL-RTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGR 574
+EKR E ++ R ++E E+ V + E+++ + +R E K+ E + E +
Sbjct: 562 EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR-EQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 575 ALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIF-- 632
+E +R QEE+ M E++ ++ E EE Q EK ++E++E
Sbjct: 621 IQEQ------EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK--MQEQEETMWR 672
Query: 633 -KEVVKVHHSTISSYLEDIILNTE-ANTAEEQARAEIEKMAEKINDIAYEMESRR 685
+E ++ I E I E EE+ + EKM E+ + + E R
Sbjct: 673 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 46.2 bits (108), Expect = 1e-04
Identities = 101/530 (19%), Positives = 215/530 (40%), Gaps = 57/530 (10%)
Query: 238 VEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLK 297
+++ ER++E +A + + L S R + E K + ++IE+LQ + + +
Sbjct: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS---QREQIEELQRQKEHLTQ 1651
Query: 298 ELLRKREENQNEVN----MKHLNARWSKLQEG--KEAKMAKIQRTHVSTIRKLVGKRKNI 351
+L R+ +E + ++ R +K+ E ++ K++ +R T ++ + + +
Sbjct: 1652 DLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAE 1711
Query: 352 EGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGL---VELESC 408
EGK + + + C ++ E +K+ +GL V S
Sbjct: 1712 EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL 1771
Query: 409 LPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQ 468
L Q + + + G LK + L +L E +AL + ++ +++ + Q
Sbjct: 1772 LLSQREQEIVVLQQQLQEAREQGELKEQS-LQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830
Query: 469 RNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLE--LIQEL 526
E + + ++ A+ L+ R + + + +RLE L E
Sbjct: 1831 GQE-----------ERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG 1879
Query: 527 RTCHALQE---DEKLVKKAEKQVTLALQRQ--RNLHEHKVSLVENHLAGLEGRALADMFD 581
R AL+E D + + +++ LALQ+Q EH+V E RAL D
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV----------ETRALQD--S 1927
Query: 582 FLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHS 641
+L + V + ++ + A +R +S R Q E R R E +E + H+
Sbjct: 1928 WLQAQAVLKERDQELEA----------LRAESQSSRHQEEAARARAE--ALQEALGKAHA 1975
Query: 642 TISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSF 701
+ + ++ E + + E + A ++ + + ++E + E +L Y
Sbjct: 1976 ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE 2035
Query: 702 LIPEVQKYFVK--EKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDE 749
+ ++Q+ + E++R+ Q + L + E+M+Q+K G++ E
Sbjct: 2036 DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE 2085
Score = 38.9 bits (89), Expect = 0.018
Identities = 114/568 (20%), Positives = 236/568 (41%), Gaps = 68/568 (11%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
+A +E++ +KR E L Q ++ K + +E A +E+E +KL ++ E
Sbjct: 1455 KAALELLSLDLKKRNQEVDL----QQEQIQELEKCRSVLEHLPMAVQERE-QKLT-VQRE 1508
Query: 295 VLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQ--RTHVSTIRKLVGKRKNIE 352
++EL + RE +N ++H K + E++ ++Q + + T+ L + +
Sbjct: 1509 QIRELEKDRETQRNV--LEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENH 1566
Query: 353 GKLE-RRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEG--------LV 403
K+E ++ +IK+ L+ L + S++ ++ ++ E L
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ 1626
Query: 404 ELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLE---- 459
E + + Q + + + +T + L E +V + ++ K+LE
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 460 -VKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGR-----VVQNMMF 513
+K R R Q +L E + ++ +++ +LR + Q +
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 514 EGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQ----RNLHEHKVSLVENHLA 569
E +E + +L Q+L+ H + L+ +Q + LQ+Q R E K +++ L
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
Query: 570 GLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEES------------GR 617
+ RALA +EL LQ+E++ ++ RV+E ++
Sbjct: 1807 EAQ-RALAQR----DQELEALQQEQQ-----QAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 618 RQVEKQRLREEDEIFKEVVKVHHSTISSYLEDII--LNTEANTAEEQARAEIEKMAEKIN 675
R E Q +E+ +E + V + + LE+++ L E+ E+ A ++ AE+
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQA-LEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
Query: 676 DIAYEMESRR---TYLQSEEIVAELVYSF--LIPEVQKYFVKEKVRNAQRKHILAAHQII 730
+ +E+E+R ++LQ++ ++ E L E Q +E+ A+ + + A
Sbjct: 1916 E--HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 731 HSYTESMVQKKLTEGEQD---EASNAAM 755
H+ + Q L + E EAS A +
Sbjct: 1974 HAALQGKEQHLLEQAELSRSLEASTATL 2001
Score = 37.0 bits (84), Expect = 0.069
Identities = 99/519 (19%), Positives = 203/519 (39%), Gaps = 109/519 (21%)
Query: 264 EKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQ 323
+ R + +++++ E + E EK Q + E L++L R+ +NQ E ++W Q
Sbjct: 1257 QTRDVLRDQVQKLEERLTDTEAEKSQ-VHTE-LQDLQRQLSQNQEE------KSKWEGKQ 1308
Query: 324 EGKEAKMAKIQRTHVST---IRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGC 380
E+++ ++ T S +R+ +R +G+ E K
Sbjct: 1309 NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK------------------ 1350
Query: 381 FPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLD 440
E L L V + + +A ++ + A +L
Sbjct: 1351 -------------------ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLK 1391
Query: 441 YELAEVHKALLDKKNKVLEVKKPP-RFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYL 499
E E + + E+K + LQ N L T TL + EEE+E +
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLA----LLTQTL---AEREEEVETLRGQI 1444
Query: 500 QKLLRGRVVQNMMFE-----------GKEKRLELIQELRTCHALQEDEKL-VKKAEKQVT 547
Q+L + R +Q E + + E IQEL C ++ E + V++ E+++T
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT 1504
Query: 548 LALQRQRNLH---EHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAE 604
+ ++ R L E + +++E+ L LE + + + ++Q+ ++ L
Sbjct: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKD-----QMIESQRGQVQDLKK-----QLVT 1554
Query: 605 RQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQAR 664
+ E EE+ + +Q+L +E E +E +V L + L+ E + E QA+
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVA-------LTHLTLDLEERSQELQAQ 1607
Query: 665 A-EIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHI 723
+ +I + +A E++ R ++S+ +E++ QR+
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVKSQ--------------------REQIEELQRQKE 1647
Query: 724 LAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQ 762
+ E M+QK+ + +D+ + +LE++ +
Sbjct: 1648 HLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Score = 36.2 bits (82), Expect = 0.12
Identities = 75/338 (22%), Positives = 147/338 (43%), Gaps = 67/338 (19%)
Query: 488 EEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDE----KLVKKAE 543
++EE+ +AV ++L Q M+ + K+ E + EL T E +L+++ +
Sbjct: 510 QQEELHLAVRERERL------QEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ 563
Query: 544 KQVTLALQR-QRNLHE-------HKVSLVENHLAGLEGRALADMFDF----LSKELVRLQ 591
+VT AL R ++++ E K + + A ++ AL + L+++L++L+
Sbjct: 564 TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE 623
Query: 592 EER-----RIHAF--------VMLAERQRR--------------VREAEESGRR-QVEKQ 623
EE R+ A V LAE ++R +++AEE+G Q + +
Sbjct: 624 EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
Query: 624 RLREE-DEIFKEVVKVHHSTISSYLEDIILNTEANTAEE-QARAEIEKMA---------E 672
++EE +EI K++ + H ++ + L+ EA EE ARA EK A
Sbjct: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743
Query: 673 KINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVR---NAQRKHILAAHQI 729
++ + + + LQ EL+ S L Q+ V E + Q + + A ++
Sbjct: 744 RLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEV 803
Query: 730 IHSYTESM---VQKKLTEGEQDEASNAAMLLEKETQNE 764
I + + + ++ EQ+ + A L + E + +
Sbjct: 804 IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Score = 34.7 bits (78), Expect = 0.34
Identities = 110/559 (19%), Positives = 219/559 (39%), Gaps = 65/559 (11%)
Query: 222 LATLTWGRGLPAGQA-----EVEMIERARE--KRAWEASLPALSDTSQFEKRRKMMN-EM 273
L LT R AGQ EV+ + + RE ++A E L Q R + +N E+
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL 496
Query: 274 ERKEWAFREQEIEKLQEIRLEV-----LKELLRKREENQNEVNMKHLNARWSKLQEGKEA 328
+ + + + Q+ E+ +E+ L V L+E+L E Q+E + + R + E
Sbjct: 497 QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEG 556
Query: 329 KMAKIQRTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSED 388
++ + ++T V+ L ++I N +K + + +L + + D
Sbjct: 557 ELLRQEQTEVTAA--LARAEQSIAELSSSENTLKTE---VADLRAAAVKLSALNEALALD 611
Query: 389 FVVKNYYLNTYEGLVELESCLPDFVTQPQ--IRAPKPKVITTKAGFLKRAARLDYELAEV 446
V N L E + + Q + ++ + + ++ L+ +L +
Sbjct: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671
Query: 447 HKALLDKKNKVLEVKKPPRFLQRNPIP---QPRLPTPTLEMTSNE----EEEMEMAVIYL 499
+A + + + ++++ +Q+ Q T LE E EE + AV
Sbjct: 672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK 731
Query: 500 QKLLRGRVVQNMMFEGKEKR----LELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRN 555
+ L+R + + + E+ E +Q L + L E + + V + Q
Sbjct: 732 EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791
Query: 556 LHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEES 615
+ V+ + + G E R L D E + ++ER A R++ +AE+
Sbjct: 792 VQIQTVTQAKEVIQG-EVRCLKLELD---TERSQAEQERDAAA--------RQLAQAEQE 839
Query: 616 GRRQVEKQRLREEDEI------FKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEK 669
G+ +E+Q+ E E+ +++ H ++ LE + E+ + E+E
Sbjct: 840 GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL----------EREKMELEM 889
Query: 670 MAEKINDIAYEMESRRTYLQSEEIVAE--LVYSFLIPEVQKYFVKEKVRNAQRKHILAAH 727
++ + EME+ + + E AE L L E ++ + E + Q K + A
Sbjct: 890 ---RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQ-KELADAS 945
Query: 728 QIIHSYTESMVQKKLTEGE 746
Q + + M +KL E E
Sbjct: 946 QQLERLRQDMKVQKLKEQE 964
Score = 32.0 bits (71), Expect = 2.2
Identities = 70/331 (21%), Positives = 131/331 (39%), Gaps = 50/331 (15%)
Query: 252 ASLPALSDTSQFEKRRK-MMNEMERKEWAFRE--QEIEKLQEIRLEVLKELLRKREENQN 308
AS L ++ + ++R+ ++ +++ K +R QE+EK RLE + +R EN
Sbjct: 37 ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEK----RLEATGGPIPQRWENVE 92
Query: 309 EVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYA 368
E N+ L R + Q+ E+ V+T +L ++ ++ K R ++ K D+
Sbjct: 93 EPNLDELLVRLEEEQQRCESL------AEVNTQLRLHMEKADVVNKALREDVEKLTVDW- 145
Query: 369 SQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVITT 428
S+ L R E F K Y + L+ L +V+T
Sbjct: 146 SRARDELMRKESQWQMEQEFF--KGYLKGEHGRLLSLWR----------------EVVTF 187
Query: 429 KAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNE 488
+ FL+ + D +L E+ + +L L+ Q R P + M E
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTC-----CLRLTVGAQSREPNGSGRMDGRE 242
Query: 489 EEEMEMAVIYLQKLL-----RGRVVQNMMFEGKEKRLELIQELRTCHAL--------QED 535
++ + + Q+L R + + + +G ++ EL + AL ++
Sbjct: 243 PAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY 302
Query: 536 EKLVKKAEKQVTLALQRQRNLHEHKVSLVEN 566
EK++K + V + L EH+ SL N
Sbjct: 303 EKMIKALRETVEILETNHTELMEHEASLSRN 333
>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
Length = 1317
Score = 46.2 bits (108), Expect = 1e-04
Identities = 110/523 (21%), Positives = 214/523 (40%), Gaps = 90/523 (17%)
Query: 235 QAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLE 294
Q E+E+ ++KR E + + + Q R K +N E+ E QE+++LQ+ + E
Sbjct: 687 QQEIEL----QKKRQEEETFLRVQEELQ---RLKELNNNEKAEKFQIFQELDQLQKEKDE 739
Query: 295 VLK--ELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIE 352
EL +KR E Q + + + + L+E K IQ ++ + +++++E
Sbjct: 740 QYAKLELEKKRLEEQEKEQVMLV----AHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLE 795
Query: 353 GKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDF 412
G E +K+ +R G D + ++ LV+L + D
Sbjct: 796 GIRESLLRVKE------------ARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDL 843
Query: 413 VTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPI 472
V Q I LK+ + + E+ E K DK++++LE K +
Sbjct: 844 VQQKDI--------------LKKEVQEEQEILECLKCEHDKESRLLE-KHDESVTDVTEV 888
Query: 473 PQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQE--LRTCH 530
PQ E E ++ LQ LL+ + + E K++ E++ L +
Sbjct: 889 PQ------DFEKIKPVEYRLQYKERQLQYLLQNHL--PTLLEEKQRAFEILDRGPLSLDN 940
Query: 531 ALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRL 590
L + EK +++ E+Q+ Q Q N N L L+ F+F + + R
Sbjct: 941 TLYQVEKEMEEKEEQLA---QYQAN---------ANQLQKLQA-----TFEF-TANIARQ 982
Query: 591 QEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLED- 649
+E+ R +L R+++ REA E ++E++ + HST+ +E+
Sbjct: 983 EEKVRKKEKEILESREKQQREALERALARLERRHSALQ----------RHSTLGMEIEEQ 1032
Query: 650 ----IILNT---EANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFL 702
LN+ E + + AE E + + + YE++ + + + V + + L
Sbjct: 1033 RQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTL 1092
Query: 703 IPEVQKYFVKEKVRNAQRKHILAAHQI-IHSYTESMVQKKLTE 744
+V + +A++ H++ I++Y E VQ++L +
Sbjct: 1093 EGKVASSSLPV---SAEKSHLVPLMDARINAYIEEEVQRRLQD 1132
Score = 30.4 bits (67), Expect = 6.5
Identities = 23/88 (26%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 259 DTSQFEKRRKMMNEMERKEWAFR------EQEIEKLQEIRLEVLKELLRKREENQN---- 308
+ + E +RK++ EME K+ + + +QE+E Q E+++ +RK+EE+
Sbjct: 605 ELEKLESKRKLIEEMEEKQKSDKAELERMQQEVE-TQRKETEIVQLQIRKQEESLKRRSF 663
Query: 309 --EVNMKHLNARWSKLQEGKEAKMAKIQ 334
E +K L A K +E + + +I+
Sbjct: 664 HIENKLKDLLAEKEKFEEERLREQQEIE 691
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,040,103
Number of Sequences: 37866
Number of extensions: 1287045
Number of successful extensions: 9362
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 506
Number of HSP's that attempted gapping in prelim test: 6530
Number of HSP's gapped (non-prelim): 2334
length of query: 767
length of database: 18,247,518
effective HSP length: 110
effective length of query: 657
effective length of database: 14,082,258
effective search space: 9252043506
effective search space used: 9252043506
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.