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Search of human proteins with 38505284
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
(2332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 4717 0.0
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 4696 0.0
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 4679 0.0
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 4638 0.0
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 4621 0.0
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 4600 0.0
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 4599 0.0
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 4560 0.0
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 4555 0.0
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 4551 0.0
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 4541 0.0
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 4502 0.0
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 4497 0.0
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 4051 0.0
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i... 2976 0.0
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 2244 0.0
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 2240 0.0
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 1471 0.0
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 1471 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 449 e-125
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 449 e-125
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 448 e-125
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 421 e-117
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 419 e-116
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 413 e-114
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 345 4e-94
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 330 8e-90
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 329 2e-89
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 329 2e-89
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 328 3e-89
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 4717 bits (12236), Expect = 0.0
Identities = 2332/2332 (100%), Positives = 2332/2332 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP
Sbjct: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 4696 bits (12180), Expect = 0.0
Identities = 2332/2377 (98%), Positives = 2332/2377 (98%), Gaps = 45/2377 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ----- 1975
FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ
Sbjct: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAE 1980
Query: 1976 ----------------------------------------MQPHPTELPGPDLLTVRKSG 1995
MQPHPTELPGPDLLTVRKSG
Sbjct: 1981 MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG 2040
Query: 1996 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2055
VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP
Sbjct: 2041 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2100
Query: 2056 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2115
HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS
Sbjct: 2101 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2160
Query: 2116 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2175
PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE
Sbjct: 2161 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2220
Query: 2176 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2235
LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ
Sbjct: 2221 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2280
Query: 2236 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2295
PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS
Sbjct: 2281 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2340
Query: 2296 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2341 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2377
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 4679 bits (12135), Expect = 0.0
Identities = 2315/2332 (99%), Positives = 2316/2332 (99%), Gaps = 11/2332 (0%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1609
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1610 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1790 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1849
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1850 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1909
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP
Sbjct: 1910 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1969
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1970 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2029
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 2030 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2089
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2090 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2149
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2150 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2209
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2210 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2269
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2270 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2321
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 4638 bits (12031), Expect = 0.0
Identities = 2309/2377 (97%), Positives = 2309/2377 (97%), Gaps = 68/2377 (2%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ----- 1975
FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ
Sbjct: 1898 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAE 1957
Query: 1976 ----------------------------------------MQPHPTELPGPDLLTVRKSG 1995
MQPHPTELPGPDLLTVRKSG
Sbjct: 1958 MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG 2017
Query: 1996 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2055
VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP
Sbjct: 2018 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2077
Query: 2056 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2115
HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS
Sbjct: 2078 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2137
Query: 2116 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2175
PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE
Sbjct: 2138 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2197
Query: 2176 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2235
LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ
Sbjct: 2198 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2257
Query: 2236 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2295
PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS
Sbjct: 2258 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2317
Query: 2296 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2318 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2354
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 4621 bits (11986), Expect = 0.0
Identities = 2292/2332 (98%), Positives = 2293/2332 (98%), Gaps = 34/2332 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1586
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1587 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1646
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1647 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1706
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1707 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1766
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1767 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1826
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1827 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1886
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP
Sbjct: 1887 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1946
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1947 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2006
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 2007 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2066
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2067 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2126
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2127 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2186
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2187 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2246
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2247 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2298
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 4600 bits (11930), Expect = 0.0
Identities = 2292/2377 (96%), Positives = 2293/2377 (96%), Gaps = 79/2377 (3%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1586
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1587 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1646
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1647 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1706
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1707 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1766
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1767 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1826
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1827 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1886
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ----- 1975
FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ
Sbjct: 1887 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAE 1946
Query: 1976 ----------------------------------------MQPHPTELPGPDLLTVRKSG 1995
MQPHPTELPGPDLLTVRKSG
Sbjct: 1947 MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG 2006
Query: 1996 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2055
VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP
Sbjct: 2007 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2066
Query: 2056 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2115
HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS
Sbjct: 2067 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2126
Query: 2116 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2175
PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE
Sbjct: 2127 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2186
Query: 2176 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2235
LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ
Sbjct: 2187 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2246
Query: 2236 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2295
PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS
Sbjct: 2247 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2306
Query: 2296 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2307 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2343
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 4599 bits (11928), Expect = 0.0
Identities = 2284/2332 (97%), Positives = 2284/2332 (97%), Gaps = 48/2332 (2%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPT MQPHP
Sbjct: 1921 FSLEHPT------------------------------------------------MQPHP 1932
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1933 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1992
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 1993 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2052
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2053 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2112
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2113 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2172
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2173 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2232
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2233 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2284
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 4560 bits (11827), Expect = 0.0
Identities = 2267/2332 (97%), Positives = 2268/2332 (97%), Gaps = 59/2332 (2%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1609
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1610 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1790 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1849
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1850 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1909
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPT MQPHP
Sbjct: 1910 FSLEHPT------------------------------------------------MQPHP 1921
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1922 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1981
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 1982 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2041
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2042 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2101
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2102 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2161
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2162 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2221
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2222 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2273
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 4555 bits (11814), Expect = 0.0
Identities = 2265/2332 (97%), Positives = 2266/2332 (97%), Gaps = 66/2332 (2%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR +AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRR------------------KAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1602
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1603 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1662
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1663 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1722
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1723 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1782
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1783 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1842
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1843 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1902
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPT MQPHP
Sbjct: 1903 FSLEHPT------------------------------------------------MQPHP 1914
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1915 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1974
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 1975 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2034
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2035 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2094
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2095 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2154
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2155 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2214
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2215 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2266
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 4551 bits (11804), Expect = 0.0
Identities = 2270/2335 (97%), Positives = 2276/2335 (97%), Gaps = 32/2335 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
Query: 1921 FSLEHPT-DRQLFDTISLL--IQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQ 1977
FSLEHPT + +SL I L L D+ + P + SA + MQ
Sbjct: 1898 FSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDD-SLPDDMHTLLLSA-----LESNMQ 1951
Query: 1978 PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV 2037
PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV
Sbjct: 1952 PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV 2011
Query: 2038 HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD 2097
HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD
Sbjct: 2012 HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD 2071
Query: 2098 VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP 2157
VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP
Sbjct: 2072 VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP 2131
Query: 2158 NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL 2217
NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL
Sbjct: 2132 NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL 2191
Query: 2218 DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR 2277
DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR
Sbjct: 2192 DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR 2251
Query: 2278 TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2252 TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 4541 bits (11779), Expect = 0.0
Identities = 2261/2332 (96%), Positives = 2261/2332 (96%), Gaps = 71/2332 (3%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPT MQPHP
Sbjct: 1898 FSLEHPT------------------------------------------------MQPHP 1909
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1910 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1969
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 1970 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2029
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2030 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2089
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2090 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2149
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2150 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2209
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2210 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2261
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 4502 bits (11678), Expect = 0.0
Identities = 2244/2332 (96%), Positives = 2245/2332 (96%), Gaps = 82/2332 (3%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1586
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1587 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1646
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1647 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1706
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1707 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1766
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1767 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1826
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1827 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1886
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPT MQPHP
Sbjct: 1887 FSLEHPT------------------------------------------------MQPHP 1898
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1899 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1958
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 1959 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2018
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2019 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2078
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2079 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2138
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2139 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2198
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2199 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2250
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 4497 bits (11665), Expect = 0.0
Identities = 2242/2332 (96%), Positives = 2243/2332 (96%), Gaps = 89/2332 (3%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR +AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRR------------------KAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1579
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1580 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1639
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1640 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1699
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1700 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1759
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1760 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1819
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1820 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1879
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPT MQPHP
Sbjct: 1880 FSLEHPT------------------------------------------------MQPHP 1891
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1892 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1951
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 1952 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2011
Query: 2101 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2160
LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG
Sbjct: 2012 LGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWG 2071
Query: 2161 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2220
KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ
Sbjct: 2072 KGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ 2131
Query: 2221 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2280
RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP
Sbjct: 2132 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPP 2191
Query: 2281 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2192 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2243
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 4051 bits (10505), Expect = 0.0
Identities = 2050/2203 (93%), Positives = 2058/2203 (93%), Gaps = 90/2203 (4%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1538 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1586
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1587 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1646
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1647 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1706
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1707 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1766
Query: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1767 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1826
Query: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1827 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1886
Query: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
FSLEHPT MQPHP
Sbjct: 1887 FSLEHPT------------------------------------------------MQPHP 1898
Query: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1899 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1958
Query: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 1959 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2018
Query: 2101 LGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCPG 2154
LGSREDLLAE PSP L + YS QS T R HS +S + P G
Sbjct: 2019 LGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
Query: 2155 PEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2195
+P+ G P +LS S + PP G PPSP
Sbjct: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 2085 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2144
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
Query: 2145 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2179
+ AP P P WG K PP RS L LD +
Sbjct: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
Query: 2180 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2239
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
Query: 2240 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2299
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
Query: 2300 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
isoform 15 [Homo sapiens]
Length = 1555
Score = 2976 bits (7716), Expect = 0.0
Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 8e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
Query: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
Query: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
Query: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
Query: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
Score = 107 bits (266), Expect = 2e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 1610 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1669
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
Query: 1670 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
Query: 1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1789
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
Query: 1790 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
Query: 1850 LMKHLEESNKEAKEEA 1865
L++ + +E+A
Sbjct: 963 LVEGFQAEEISKREDA 978
Score = 103 bits (256), Expect = 3e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1598 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1655
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1656 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1711
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
Query: 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
Score = 68.2 bits (165), Expect = 9e-11
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)
Query: 1548 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1593
EEE+ EE + R + L+D+ +G SA SEA+ PY
Sbjct: 3 EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
Query: 1594 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1643
S SR R + + + VI LN VT+ M + D L
Sbjct: 58 PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 1644 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1700
+ + F +E V K+VA FG + + D WN+LD IV+ ++ +L+ V+ S
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
Query: 1701 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1760
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFIF +
Sbjct: 178 A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
Query: 1761 GVELFGDL 1768
GV+L+ L
Sbjct: 229 GVQLWAGL 236
Score = 61.2 bits (147), Expect = 1e-08
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 35.8 bits (81), Expect = 0.51
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
Query: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1863
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 2244 bits (5816), Expect = 0.0
Identities = 1320/2409 (54%), Positives = 1537/2409 (63%), Gaps = 226/2409 (9%)
Query: 7 GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
GA E G P G P +AE+ E + +PYPALA VFF L Q
Sbjct: 27 GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
Query: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
+RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86 TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
Query: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD NVS SA+RTVRVLR
Sbjct: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
Query: 247 FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
F ++ R YYQTE +E+PFICS R+NGM+ C +P G PC L +EAY
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
Query: 306 NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
++ C+NWNQYY C +G+ NP GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
Query: 359 IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
Query: 419 NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
N STLASFSEPGSCYEELLKY+ +I RK RR ++ R P+ + GQ P
Sbjct: 443 NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
Query: 479 SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
R+ R SVHHLV HHHHHHHHHYH +G+ R P P D +R +
Sbjct: 501 GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
Query: 537 PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
P +P G P AESVHS YHADCH+E + +A + + A+ G G + YPT
Sbjct: 556 PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
Query: 593 V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
+ TSP P+ K GP +L S P PY + ++ G
Sbjct: 616 ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
Query: 643 ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
+S PC A + C SCPYC RA E EL+ E DSD VYEF
Sbjct: 671 QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
Query: 697 TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
TQD +H D DP RR + EP + W R+IV
Sbjct: 731 TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
Query: 741 DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL GP
Sbjct: 791 DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
Query: 801 GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
GYI+NPYNIFDG+IVVISVWEIVGQ GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 861 TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
Query: 920 LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE
Sbjct: 971 LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
Query: 980 GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030
GDAN+S+++ D S + D + K C V+ H E
Sbjct: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
Query: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
R SL PPLI+ TAATPM PKS+ P SRR SSS P + K P S R
Sbjct: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
Query: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150
SSP +PW + +W+SRRSS +SLGRAPSLKRR GER SLLSGEG+ S D+E
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
Query: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210
P + R SL+ LP T + +D +G+ +
Sbjct: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
Query: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270
LR D D + DD+ S R+ + P C R++W+ Y+F PQ+RFR+ C
Sbjct: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
Query: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
Query: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
ALG GE AYL+SSWN+LDGLLVL+S++DI+V+M S G KILG+LRVLRLLRTLRPLR
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
Query: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
Query: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
K+ C A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
Query: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNL 1570
PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RR
Sbjct: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR-- 1586
Query: 1571 MLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1630
S + EAQ +PYY+DYS R +H LCTSHYLDLFIT +I +NV+TM+M
Sbjct: 1587 ----------STFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1636
Query: 1631 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1690
EHY QP+ LDEALK CNY+FT++FV E+ KLVAFGFRRFF+DRWNQLDLAIVLLS+MGI
Sbjct: 1637 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1696
Query: 1691 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1750
TLEEIE++A+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLF
Sbjct: 1697 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1756
Query: 1751 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1810
MLLFFI+AALGVELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKD
Sbjct: 1757 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1816
Query: 1811 TLRDC---DQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
TLR+C D+ Y +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL
Sbjct: 1817 TLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL 1876
Query: 1868 EAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP---DSPKPGALHPAAHARSASHF--- 1921
+AE+ELEM +GP S D+ +P + AR A +
Sbjct: 1877 DAEIELEM-------------------AQGPGSARRVDADRPPLPQESPGARDAPNLVAR 1917
Query: 1922 ------SLEHPTDRQLFDTISLLIQGSLEWELKLMD---ELAGPG---GQPSAFPSAPSL 1969
L P D +F + + S L + E G G G ++ S P+
Sbjct: 1918 KVSVSRMLSLPNDSYMFRPV---VPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAE 1974
Query: 1970 GGSDPQMQPHPTELP---GPDLLTVRKSGVSRTHSLPNDSYMCR----HGSTAEGPLGHR 2022
+ Q+ P P G L + G +R+ SL +CR H + EG +
Sbjct: 1975 SCASLQI-PLAVSSPARSGEPLHALSPRGTARSPSL--SRLLCRQEAVHTDSLEGKIDSP 2031
Query: 2023 GWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAP-TWG--TIPKLP--PPGR 2077
L A+ G V +P LQ P +P + T+G + P P G
Sbjct: 2032 RDTLDPAEPGEKTPV--RPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE 2089
Query: 2078 SPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGP--SPPLARAYSFWGQSSTQAQQH 2135
A P + + T S AE GP SP S AQ
Sbjct: 2090 EAEASDPADEEVSHITSS------ACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGF 2143
Query: 2136 SRSHSKISKHMTPPAPCPGPEPNWGKG-PPETRSSLELDTELSWISGDLLPPGGQEEPPS 2194
+ + P A EP K PE +L + + PP EPP+
Sbjct: 2144 LDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKK-----MSPPCISVEPPA 2198
Query: 2195 PRDLKKCYSVE---AQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLG 2251
+ S + + +RR S R S+ +P T+ S GG P
Sbjct: 2199 EDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSL---------EP---TEGSGAGGDPAA 2246
Query: 2252 -----GPGSRPKKKLSPPSITIDPPESQGPRTPP----SPGICLRRRAPSSDSKDPLASG 2302
G S + L+ PS +P + P P S + RA SS + PL
Sbjct: 2247 KGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLE-- 2304
Query: 2303 PPDSMAASP 2311
PP+S P
Sbjct: 2305 PPESEPPMP 2313
Score = 108 bits (271), Expect = 5e-23
Identities = 135/431 (31%), Positives = 184/431 (42%), Gaps = 76/431 (17%)
Query: 1943 LEWELKLMDELA-GPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTVRKSGVSRTHS 2001
L+ E++L E+A GPG P L PQ P + P L RK VSR S
Sbjct: 1876 LDAEIEL--EMAQGPGSARRVDADRPPL----PQESPGARDAPN---LVARKVSVSRMLS 1926
Query: 2002 LPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPK 2052
LPNDSYM R A P + G G P GSV SVHS PA++ LQ+P
Sbjct: 1927 LPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPL---GSVASVHSPPAESCASLQIP- 1982
Query: 2053 DAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE 2110
L A + + L P G RSP R L RQ A+ TDSL+ + R+ L
Sbjct: 1983 ----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPA 2038
Query: 2111 VSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE 2165
G P P+ + S +S A +R H+ + ++ PG E E
Sbjct: 2039 EPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------E 2090
Query: 2166 TRSSLELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSW 2216
+S D E+S I+ P P G E P RDL++ YSV+AQ +P
Sbjct: 2091 AEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR- 2149
Query: 2217 LDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQG 2275
DEQ R S + + G G + +P G+R KKK+SPP I+++PP E +G
Sbjct: 2150 ADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEG 2202
Query: 2276 PRTPPSP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPSPKKDVLS 2319
P + LRRR PS DS +P A G P + S + + L+
Sbjct: 2203 SARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLT 2262
Query: 2320 LSGLSSDPADL 2330
+ + +P DL
Sbjct: 2263 VPSFAFEPLDL 2273
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 2240 bits (5805), Expect = 0.0
Identities = 1318/2409 (54%), Positives = 1535/2409 (63%), Gaps = 232/2409 (9%)
Query: 7 GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
GA E G P G P +AE+ E + +PYPALA VFF L Q
Sbjct: 27 GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
Query: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
+RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86 TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
Query: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD NVS SA+RTVRVLR
Sbjct: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
Query: 247 FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
F ++ R YYQTE +E+PFICS R+NGM+ C +P G PC L +EAY
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
Query: 306 NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
++ C+NWNQYY C +G+ NP GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
Query: 359 IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
Query: 419 NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
N STLASFSEPGSCYEELLKY+ +I RK RR ++ R P+ + GQ P
Sbjct: 443 NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
Query: 479 SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
R+ R SVHHLV HHHHHHHHHYH +G+ R P P D +R +
Sbjct: 501 GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
Query: 537 PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
P +P G P AESVHS YHADCH+E + +A + + A+ G G + YPT
Sbjct: 556 PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
Query: 593 V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
+ TSP P+ K GP +L S P PY + ++ G
Sbjct: 616 ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
Query: 643 ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
+S PC A + C SCPYC RA E EL+ E DSD VYEF
Sbjct: 671 QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
Query: 697 TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
TQD +H D DP RR + EP + W R+IV
Sbjct: 731 TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
Query: 741 DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL GP
Sbjct: 791 DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
Query: 801 GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
GYI+NPYNIFDG+IVVISVWEIVGQ GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 861 TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
Query: 920 LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE
Sbjct: 971 LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
Query: 980 GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030
GDAN+S+++ D S + D + K C V+ H E
Sbjct: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
Query: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
R SL PPLI+ TAATPM PKS+ P SRR SSS P + K P S R
Sbjct: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
Query: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150
SSP +PW + +W+SRRSS +SLGRAPSLKRR GER SLLSGEG+ S D+E
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
Query: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210
P + R SL+ LP T + +D +G+ +
Sbjct: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
Query: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270
LR D D + DD+ S R+ + P C R++W+ Y+F PQ+RFR+ C
Sbjct: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
Query: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
Query: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
ALG GE AYL+SSWN+LDGLLVL+S++DI+V+M S G KILG+LRVLRLLRTLRPLR
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
Query: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
Query: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
K+ C A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
Query: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNL 1570
PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RR
Sbjct: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR-- 1586
Query: 1571 MLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1630
+AQ +PYY+DYS R +H LCTSHYLDLFIT +I +NV+TM+M
Sbjct: 1587 ----------------KAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1630
Query: 1631 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1690
EHY QP+ LDEALK CNY+FT++FV E+ KLVAFGFRRFF+DRWNQLDLAIVLLS+MGI
Sbjct: 1631 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1690
Query: 1691 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1750
TLEEIE++A+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLF
Sbjct: 1691 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1750
Query: 1751 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1810
MLLFFI+AALGVELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKD
Sbjct: 1751 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1810
Query: 1811 TLRDC---DQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
TLR+C D+ Y +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL
Sbjct: 1811 TLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL 1870
Query: 1868 EAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP---DSPKPGALHPAAHARSASHF--- 1921
+AE+ELEM +GP S D+ +P + AR A +
Sbjct: 1871 DAEIELEM-------------------AQGPGSARRVDADRPPLPQESPGARDAPNLVAR 1911
Query: 1922 ------SLEHPTDRQLFDTISLLIQGSLEWELKLMD---ELAGPG---GQPSAFPSAPSL 1969
L P D +F + + S L + E G G G ++ S P+
Sbjct: 1912 KVSVSRMLSLPNDSYMFRPV---VPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAE 1968
Query: 1970 GGSDPQMQPHPTELP---GPDLLTVRKSGVSRTHSLPNDSYMCR----HGSTAEGPLGHR 2022
+ Q+ P P G L + G +R+ SL +CR H + EG +
Sbjct: 1969 SCASLQI-PLAVSSPARSGEPLHALSPRGTARSPSL--SRLLCRQEAVHTDSLEGKIDSP 2025
Query: 2023 GWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAP-TWG--TIPKLP--PPGR 2077
L A+ G V +P LQ P +P + T+G + P P G
Sbjct: 2026 RDTLDPAEPGEKTPV--RPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE 2083
Query: 2078 SPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGP--SPPLARAYSFWGQSSTQAQQH 2135
A P + + T S AE GP SP S AQ
Sbjct: 2084 EAEASDPADEEVSHITSS------ACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGF 2137
Query: 2136 SRSHSKISKHMTPPAPCPGPEPNWGKG-PPETRSSLELDTELSWISGDLLPPGGQEEPPS 2194
+ + P A EP K PE +L + + PP EPP+
Sbjct: 2138 LDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKK-----MSPPCISVEPPA 2192
Query: 2195 PRDLKKCYSVE---AQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLG 2251
+ S + + +RR S R S+ +P T+ S GG P
Sbjct: 2193 EDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSL---------EP---TEGSGAGGDPAA 2240
Query: 2252 -----GPGSRPKKKLSPPSITIDPPESQGPRTPP----SPGICLRRRAPSSDSKDPLASG 2302
G S + L+ PS +P + P P S + RA SS + PL
Sbjct: 2241 KGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLE-- 2298
Query: 2303 PPDSMAASP 2311
PP+S P
Sbjct: 2299 PPESEPPMP 2307
Score = 108 bits (271), Expect = 5e-23
Identities = 135/431 (31%), Positives = 184/431 (42%), Gaps = 76/431 (17%)
Query: 1943 LEWELKLMDELA-GPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTVRKSGVSRTHS 2001
L+ E++L E+A GPG P L PQ P + P L RK VSR S
Sbjct: 1870 LDAEIEL--EMAQGPGSARRVDADRPPL----PQESPGARDAPN---LVARKVSVSRMLS 1920
Query: 2002 LPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPK 2052
LPNDSYM R A P + G G P GSV SVHS PA++ LQ+P
Sbjct: 1921 LPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPL---GSVASVHSPPAESCASLQIP- 1976
Query: 2053 DAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE 2110
L A + + L P G RSP R L RQ A+ TDSL+ + R+ L
Sbjct: 1977 ----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPA 2032
Query: 2111 VSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE 2165
G P P+ + S +S A +R H+ + ++ PG E E
Sbjct: 2033 EPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------E 2084
Query: 2166 TRSSLELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSW 2216
+S D E+S I+ P P G E P RDL++ YSV+AQ +P
Sbjct: 2085 AEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR- 2143
Query: 2217 LDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQG 2275
DEQ R S + + G G + +P G+R KKK+SPP I+++PP E +G
Sbjct: 2144 ADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEG 2196
Query: 2276 PRTPPSP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPSPKKDVLS 2319
P + LRRR PS DS +P A G P + S + + L+
Sbjct: 2197 SARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLT 2256
Query: 2320 LSGLSSDPADL 2330
+ + +P DL
Sbjct: 2257 VPSFAFEPLDL 2267
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 1471 bits (3809), Expect = 0.0
Identities = 913/1777 (51%), Positives = 1085/1777 (61%), Gaps = 269/1777 (15%)
Query: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
A P SCP C +G G + + +E S S A E +A R
Sbjct: 512 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
Query: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 569 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
Query: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 629 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
Query: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 689 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
Query: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 749 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
Query: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 809 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
Query: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
S + LD GD K C ++ H L P SLP
Sbjct: 846 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
Query: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 889 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
Query: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 949 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
Query: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
Query: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
Query: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
Query: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361
Query: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1421
Query: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622
LEKKRR +AQ PYY+ Y RLL+H +CTSHYLD+FIT +I
Sbjct: 1422 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1463
Query: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682
LNVVTM++EHY QP L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1464 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1523
Query: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742
VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1524 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1583
Query: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802
VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1584 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
Query: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859
NWNGIMKDTLRDC E +C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1644 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1703
Query: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSA 1918
EA+E+AE++AELELEM L P P P GS PG G PG
Sbjct: 1704 EAQEDAEMDAELELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGG 1753
Query: 1919 SHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMDELAG--------PGG----------- 1958
P L+ D++SL+I+ SLE EL ++D L+G P G
Sbjct: 1754 LCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEV 1813
Query: 1959 ---QPSAFP-----SAPSLGGSD----------PQMQPHPTELPGPDLLTVRKSG----- 1995
+ AF S+ L G D P + EL P+ + V G
Sbjct: 1814 QLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFP 1873
Query: 1996 VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDA 2054
+S T P+ ++++C P+ R W K S P +S +L +P +
Sbjct: 1874 LSSTAVSPDPENFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEF 1929
Query: 2055 PH------LLQPHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS 2103
H P GT+PK+ G RSP L RQA SLD
Sbjct: 1930 FHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD------ 1983
Query: 2104 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2163
+ PS + S T + R+ + PPAP PGP
Sbjct: 1984 --------ASPSSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS--- 2025
Query: 2164 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2223
P R L L R L + A QR H
Sbjct: 2026 PAARRRLSL---------------------RGRGLFSLRGLRA------------HQRSH 2052
Query: 2224 SIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTP 2279
S S G H DPS+ GG GG GS + LS S+T + P P P
Sbjct: 2053 SSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPP 2107
Query: 2280 PSPGICLRRRAPSSDS----KDPLASGPPDSMAASPS 2312
P+PG+ R+ S+ S P A+ +A SPS
Sbjct: 2108 PAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPS 2144
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
Query: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Y+ +ILRKA RR + +A R L AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Score = 112 bits (279), Expect = 6e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
Query: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
Query: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
Query: 233 WAG 235
+ G
Sbjct: 1293 FKG 1295
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
Query: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
Query: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
Query: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
+G E SG S ++ G G R A + G + E E V+
Sbjct: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
Query: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
Score = 62.0 bits (149), Expect = 7e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
Score = 55.8 bits (133), Expect = 5e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
Query: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
Query: 1588 AQC 1590
C
Sbjct: 432 GDC 434
Score = 50.4 bits (119), Expect = 2e-05
Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 965 EGFQAEEISKRE 976
F E +RE
Sbjct: 399 TQF--SETKQRE 408
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
Query: 396 TQF 398
F
Sbjct: 828 EGF 830
Score = 38.1 bits (87), Expect = 0.10
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
Score = 35.0 bits (79), Expect = 0.86
Identities = 36/168 (21%), Positives = 63/168 (37%), Gaps = 47/168 (27%)
Query: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
Query: 1845 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1889
+ + V+ E+ ++ E LE + LS + P
Sbjct: 392 LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
Query: 1890 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL 1923
L+ ++ GP++P KPG HA+ H+ L
Sbjct: 447 RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQL 489
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 1471 bits (3809), Expect = 0.0
Identities = 913/1777 (51%), Positives = 1085/1777 (61%), Gaps = 269/1777 (15%)
Query: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
A P SCP C +G G + + +E S S A E +A R
Sbjct: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
Query: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
Query: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
Query: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
Query: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
Query: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
Query: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
S + LD GD K C ++ H L P SLP
Sbjct: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
Query: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
Query: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
Query: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
Query: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
Query: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
Query: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396
Query: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456
Query: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622
LEKKRR +AQ PYY+ Y RLL+H +CTSHYLD+FIT +I
Sbjct: 1457 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1498
Query: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682
LNVVTM++EHY QP L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1499 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1558
Query: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742
VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1559 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1618
Query: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802
VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1619 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
Query: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859
NWNGIMKDTLRDC E +C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1679 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1738
Query: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSA 1918
EA+E+AE++AELELEM L P P P GS PG G PG
Sbjct: 1739 EAQEDAEMDAELELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGG 1788
Query: 1919 SHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMDELAG--------PGG----------- 1958
P L+ D++SL+I+ SLE EL ++D L+G P G
Sbjct: 1789 LCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEV 1848
Query: 1959 ---QPSAFP-----SAPSLGGSD----------PQMQPHPTELPGPDLLTVRKSG----- 1995
+ AF S+ L G D P + EL P+ + V G
Sbjct: 1849 QLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFP 1908
Query: 1996 VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDA 2054
+S T P+ ++++C P+ R W K S P +S +L +P +
Sbjct: 1909 LSSTAVSPDPENFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEF 1964
Query: 2055 PH------LLQPHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS 2103
H P GT+PK+ G RSP L RQA SLD
Sbjct: 1965 FHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD------ 2018
Query: 2104 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2163
+ PS + S T + R+ + PPAP PGP
Sbjct: 2019 --------ASPSSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS--- 2060
Query: 2164 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2223
P R L L R L + A QR H
Sbjct: 2061 PAARRRLSL---------------------RGRGLFSLRGLRA------------HQRSH 2087
Query: 2224 SIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTP 2279
S S G H DPS+ GG GG GS + LS S+T + P P P
Sbjct: 2088 SSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPP 2142
Query: 2280 PSPGICLRRRAPSSDS----KDPLASGPPDSMAASPS 2312
P+PG+ R+ S+ S P A+ +A SPS
Sbjct: 2143 PAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPS 2179
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
Query: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Y+ +ILRKA RR + +A R L AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Score = 112 bits (279), Expect = 6e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
Query: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 233 WAG 235
+ G
Sbjct: 1328 FKG 1330
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
Query: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
Query: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
Query: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
+G E SG S ++ G G R A + G + E E V+
Sbjct: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
Query: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
Score = 62.0 bits (149), Expect = 7e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
Score = 55.8 bits (133), Expect = 5e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
Query: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
Query: 1588 AQC 1590
C
Sbjct: 432 GDC 434
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
F Q E E LS + ++ GD E + L RK
Sbjct: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
+ L + + R+ L P A P + G + G R S G
Sbjct: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
Query: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
Query: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
+ SG+ S GE + D SSE+ +S G +
Sbjct: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 396 TQF 398
F
Sbjct: 863 EGF 865
Score = 38.1 bits (87), Expect = 0.10
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
Query: 1845 VVIAVLMKHLEESNK 1859
+ + V+ E+ +
Sbjct: 392 LCLVVIATQFSETKQ 406
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 449 bits (1156), Expect = e-125
Identities = 330/1164 (28%), Positives = 566/1164 (48%), Gaps = 111/1164 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG S + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIM 1492
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DIM
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 1493 YDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA 1552
Y +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 1553 RRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHY 1612
EE +KK N M S+ KP ++++ + + T
Sbjct: 1486 FMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
Query: 1613 LDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF E + KL A +F
Sbjct: 1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYF 1587
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+ WN D +V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1588 TNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRT 1645
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1791
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F +
Sbjct: 1646 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANS 1700
Query: 1792 FLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQ 1839
L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1701 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1760
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKE 1863
++VN+ IA+++++ + +E+ E
Sbjct: 1761 LIVVNMYIAIILENFSVATEESTE 1784
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
Score = 125 bits (314), Expect = 5e-28
Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849
G F ++++P+N D VI++ E V G +S LRTFR+ ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
Query: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
Query: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
+ ++I VLN+F+ +++ +F
Sbjct: 920 LLVMVIGNLVVLNLFLALLLSSF 942
Score = 118 bits (296), Expect = 6e-26
Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I +DL NVS A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ + ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 103 bits (257), Expect = 2e-21
Identities = 89/370 (24%), Positives = 156/370 (42%), Gaps = 79/370 (21%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ V LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
+ LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1566 KRRNLMLDDV 1575
+ L + V
Sbjct: 444 EHEALTIRGV 453
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
Query: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
Score = 72.4 bits (176), Expect = 5e-12
Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)
Query: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
K++A GF F +D WN LD +++ IM T E +++ + R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
Query: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 9e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Score = 32.7 bits (73), Expect = 4.3
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 449 bits (1156), Expect = e-125
Identities = 330/1164 (28%), Positives = 566/1164 (48%), Gaps = 111/1164 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG S + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIM 1492
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DIM
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 1493 YDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA 1552
Y +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 1553 RRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHY 1612
EE +KK N M S+ KP ++++ + + T
Sbjct: 1486 FMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
Query: 1613 LDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF E + KL A +F
Sbjct: 1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYF 1587
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+ WN D +V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1588 TNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRT 1645
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1791
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F +
Sbjct: 1646 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANS 1700
Query: 1792 FLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQ 1839
L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1701 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1760
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKE 1863
++VN+ IA+++++ + +E+ E
Sbjct: 1761 LIVVNMYIAIILENFSVATEESTE 1784
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
Score = 125 bits (313), Expect = 6e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
Query: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
Query: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
+ ++I VLN+F+ +++ +F
Sbjct: 920 LLVMVIGNLVVLNLFLALLLSSF 942
Score = 120 bits (301), Expect = 2e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 104 bits (260), Expect = 9e-22
Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1566 KRRNLMLDDV 1575
+ L + V
Sbjct: 444 EHEALTIRGV 453
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
Query: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
Query: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 9e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Score = 32.7 bits (73), Expect = 4.3
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 448 bits (1152), Expect = e-125
Identities = 329/1164 (28%), Positives = 565/1164 (48%), Gaps = 112/1164 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVS 1082
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1083 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1140
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1191
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1251
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1252 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1304
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1305 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1364
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIM 1492
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DIM
Sbjct: 1365 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424
Query: 1493 YDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA 1552
Y +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484
Query: 1553 RRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHY 1612
EE +KK N M S+ KP ++++ + + T
Sbjct: 1485 FMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1528
Query: 1613 LDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF E + KL A +F
Sbjct: 1529 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYF 1586
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+ WN D +V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1587 TNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRT 1644
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1791
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F +
Sbjct: 1645 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANS 1699
Query: 1792 FLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQ 1839
L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1700 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1759
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKE 1863
++VN+ IA+++++ + +E+ E
Sbjct: 1760 LIVVNMYIAIILENFSVATEESTE 1783
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520
Score = 125 bits (314), Expect = 5e-28
Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849
G F ++++P+N D VI++ E V G +S LRTFR+ ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
Query: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
Query: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
+ ++I VLN+F+ +++ +F
Sbjct: 920 LLVMVIGNLVVLNLFLALLLSSF 942
Score = 118 bits (296), Expect = 6e-26
Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I +DL NVS A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ + ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 103 bits (257), Expect = 2e-21
Identities = 89/370 (24%), Positives = 156/370 (42%), Gaps = 79/370 (21%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ V LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
+ LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1566 KRRNLMLDDV 1575
+ L + V
Sbjct: 444 EHEALTIRGV 453
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1582
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1583 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1641
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1642 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1697
Query: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1698 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1757
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1758 SFLIVVNMYIAIILENFSVATEESTEPLS 1786
Score = 72.4 bits (176), Expect = 5e-12
Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)
Query: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
K++A GF F +D WN LD +++ IM T E +++ + R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
Query: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 9e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1529 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1581
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1582 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1640
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1641 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679
Score = 32.7 bits (73), Expect = 4.3
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 421 bits (1081), Expect = e-117
Identities = 324/1160 (27%), Positives = 550/1160 (47%), Gaps = 141/1160 (12%)
Query: 749 IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
I + I+VNT+ M +E+H L+I NIVFT F EM+ K++ + P+ Y + +N
Sbjct: 671 ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
Query: 809 IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
IFD +IV +S+ E+ + G LSVLR+FRL+RV KL + P L + ++ ++ +
Sbjct: 731 IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
Query: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924
++L + +F+F+++G L G + + R + P R + + + VF+IL E
Sbjct: 791 TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
Query: 925 WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLS 983
W + ++ M S + F+ +M GN V+ NL +A+L+ F A+ ++ ED G+++
Sbjct: 850 WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPED-DGEVN 908
Query: 984 CIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1042
+Q+ + Q ++ FFS S P + P L++
Sbjct: 909 NLQVALARIQVFGHRTKQALCSFFSRSC------------------PFPQPKAEPELVV- 949
Query: 1043 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
LP S+S +R +S A G E HS + A +
Sbjct: 950 ------KLPLSSSKAENHIAANTARGSSGGLQAPRGPRDE-----------HSDFIANPT 992
Query: 1103 -WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHR 1161
W S + G + GE E +E+ + ER DH
Sbjct: 993 VWVSVPIAE---GESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTP 1045
Query: 1162 GSLEREAKSSFDLPDTL----------QVP--GLHRTASGRGSASEHQDCNGKSASGRLA 1209
S SS DL +L QVP G+ T+S GS DC R
Sbjct: 1046 RS-PGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKI 1101
Query: 1210 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRL 1267
L D + DD EG + P C L+ + W + R
Sbjct: 1102 PELADDLE--EPDDCFTEGCIR-----------HCPCCKLDTTKSPWDV-----GWQVRK 1143
Query: 1268 LCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTV 1327
C+RI+ H F+ ++ +I L+ ++A E +D + L ++ +FT +F+ EM +
Sbjct: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
Query: 1328 KVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLR 1387
K VA G+ + Y ++W LD L+V IS+I + ++ S + ++ LR LR LR
Sbjct: 1204 KWVAYGF----KKYFTNAWCWLDFLIVNISLISLTAKILEYSE---VAPIKALRTLRALR 1256
Query: 1388 PLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QG 1443
PLR +SR +G+++VV+ L+ ++ I N++++C F++IF I+GV LF GKF+ C G
Sbjct: 1257 PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDG 1316
Query: 1444 EDT----RNITNKSDC----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1495
E + + NKSDC + S+ WV K NFDN+ ++L +A+ GW+DIMY
Sbjct: 1317 EFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAA 1376
Query: 1496 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRR 1555
+D+ V+ QP N +M LYF+ F++ FF LN+FVGV+++NF++ ++ ++
Sbjct: 1377 VDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMT 1436
Query: 1556 EEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDL 1615
EE +KK N M S+ KP ++F+ V + T D+
Sbjct: 1437 EE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDI 1480
Query: 1616 FITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRW 1675
I +I LN++TM +E Q + + L N F +F E V K+ A + +F + W
Sbjct: 1481 TIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGW 1539
Query: 1676 NQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDT 1735
N D +V+LSI + I + +PT+ R++R+ RI R+L+L++ A G+R LL
Sbjct: 1540 NVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFA 1599
Query: 1736 VMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTL 1795
+M +LP + N+GLL L+ FI++ G+ F + + G+ F+ F + L L
Sbjct: 1600 LMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCL 1654
Query: 1796 FRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLV 1843
F+++T W+G++ L CD C + + I+F ++++ + ++V
Sbjct: 1655 FQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMV 1714
Query: 1844 NVVIAVLMKHLEESNKEAKE 1863
N+ IAV++++ + +E+ E
Sbjct: 1715 NMYIAVILENFNVATEESTE 1734
Score = 128 bits (321), Expect = 7e-29
Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128
R C R V + WFE + +ILL+ +L ED D + + L + D +F F F
Sbjct: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
Query: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181
EM++K VA +G K Y + W LDF IV A +LEYS + A+RT
Sbjct: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
Query: 182 VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG RC
Sbjct: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
Query: 242 --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298
+ FSL PLS+ N C+
Sbjct: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
Query: 299 GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
NS+ + VN + N + G ++A+ QV T +GW+D
Sbjct: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
Query: 359 IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405
IMY +D+ + Y ++YF++ II G FF +NL + VI F++ K++ +
Sbjct: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
Query: 406 SQLMREQRVRFLSNASTLAS 425
M E++ ++ + L S
Sbjct: 1432 DIFMTEEQKKYYNAMKKLGS 1451
Score = 124 bits (311), Expect = 1e-27
Identities = 186/899 (20%), Positives = 344/899 (38%), Gaps = 191/899 (21%)
Query: 723 SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777
S+ A W LI T K+ +F I + ILVN + M T+ E
Sbjct: 105 SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
Query: 778 SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832
VFT ++ E L+K+L G F Y+++P+N D VI + V + +G +S
Sbjct: 156 IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
Query: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888
LRTFR++R LK V +P L+ + L+ ++ +A +L + + +F+++G+ LF
Sbjct: 214 LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
Query: 889 -------------CKFASERDGDTLPDRK------------------------------- 904
++S R D +++
Sbjct: 274 NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
Query: 905 ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
+FDS WA +++F+++TQ+ W + LY L T G + ++
Sbjct: 334 FNYTSFDSFAWAFLSLFRLMTQDSWER--------------LYQQTLRTSGKIYMIFFVL 379
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQG-GDANKSESEPDFFSPSLDGDGDRKKC 1019
I + F + L+ + + + Q ++ E++ F +L+ ++
Sbjct: 380 VIFLGSFYLVNLI--------LAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEV 431
Query: 1020 LALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGA 1079
LA + + + L PL A+ RR G+
Sbjct: 432 LAALGI-DTTSLHSHNGSPLTSKNAS--------------------ERRHRIKPRVSEGS 470
Query: 1080 AHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLG--RAPSLKRRSPSG----------- 1126
+ KSP S + + RR+S S+ R+P P G
Sbjct: 471 TEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDH 530
Query: 1127 --ERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLH 1184
R SLL G G Q S + P+ D RH + +S P + V
Sbjct: 531 ESHRGSLLLGGGAGQQGPLPRSPLPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFD 588
Query: 1185 RTASGRGSASEHQD--CNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242
++E+ D + A ++ + + + S ++ W
Sbjct: 589 AGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW--- 645
Query: 1243 RLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDP 1302
CC P + + + ++T + + + I +N I +AME + P
Sbjct: 646 ---DCC-----------PMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP 691
Query: 1303 HSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDIL 1362
L + N +FT F AEM K++A F Y + WN+ D ++V +S++++
Sbjct: 692 --TFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL- 744
Query: 1363 VSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAF 1422
G G L VLR R LR ++ L +++ + +S+ +GN+ +I
Sbjct: 745 -------GVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
Query: 1423 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFV 1481
+F ++G QL GE+ RN N+ + + W R H ++F L+ +
Sbjct: 798 VFVFALVGKQLL--------GENYRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRI 845
Query: 1482 LASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540
L + W++ M+ ++ V Q+ I L+ F++ +++ VLN+F+ +++ +F
Sbjct: 846 LCGE--WIENMWACME---VGQKSI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
Score = 118 bits (296), Expect = 6e-26
Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R ++ + WF + IL+NCV + R + + + +
Sbjct: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
E ++K++A G + YL D WN LDF ++ + ++DL+ +S +RT RVLR L+
Sbjct: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
Query: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
++ +P ++++V L+ ++ L +V +L F +F +VG+QL+ G L+N+C +
Sbjct: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
Query: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309
++V+ Y + + P I R S P L G+G C Y +S
Sbjct: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
Query: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369
NP +FD+ +A++++F+++T + W + +
Sbjct: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
Query: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+ + E Q + + + +F
Sbjct: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
Score = 106 bits (264), Expect = 3e-22
Identities = 80/348 (22%), Positives = 149/348 (42%), Gaps = 67/348 (19%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
++F P + R ++ H F + V I +NC+ M R + P E Y+
Sbjct: 111 WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FT ++ E +K++A G+C E YLR WN LD ++ ++ + + + SG
Sbjct: 160 FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
LR R LR L+ +S GLK++V L+ S+K + ++ ++ +F ++G+QLFKG
Sbjct: 214 ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
Query: 1437 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1460
+C G D+ + + C + S
Sbjct: 271 NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
Query: 1461 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1520
+ +FD+ A +SLF L ++D W + QQ + +++F+
Sbjct: 331 NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
Query: 1521 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR 1568
+ + +F+++N+ + VV + + Q +E +E+K LE R+
Sbjct: 381 IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRK 427
Score = 105 bits (261), Expect = 7e-22
Identities = 81/317 (25%), Positives = 149/317 (47%), Gaps = 36/317 (11%)
Query: 1565 KKRRNLMLDDVIASGSSASAASEAQCKPYYSDYS-------------RFRLLVHHLCTSH 1611
+ +R + + +I S SE +C P + S + + ++ L T
Sbjct: 606 RAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDP 665
Query: 1612 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
+ +L IT I +N + MAMEH+ + L+I N +FT+ F E VFK++AF +F
Sbjct: 666 FAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYF 725
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
Q +WN D IV +S++ + + + + ++R R+ RV KL K +
Sbjct: 726 QKKWNIFDCIIVTVSLLELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNT 775
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRN 1787
L+ + ++ +GNL ++ ++ F+FA +G +L G+ + + P E R +
Sbjct: 776 LIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHD 834
Query: 1788 FGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVI 1847
F +FL +FR+ G+ W M + + Q+S C I F++ ++ V++N+ I
Sbjct: 835 FFHSFLIVFRILCGE-WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFI 886
Query: 1848 AVLMKHLEESNKEAKEE 1864
A+L+ N A E+
Sbjct: 887 ALLLNSFSADNLTAPED 903
Score = 96.7 bits (239), Expect = 2e-19
Identities = 122/527 (23%), Positives = 207/527 (39%), Gaps = 146/527 (27%)
Query: 1575 VIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ 1634
V+ G + S S + +S ++ R + + LFIT I +N V M
Sbjct: 94 VLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD-- 151
Query: 1635 QPQILDEALKICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGI 1690
L E ++ Y+FTVI+ E++ K++A GF + +D WN LD +++ L+ +G
Sbjct: 152 ----LPEKIE---YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGT 204
Query: 1691 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1750
++ ++ +R R+ R LK + + G++ ++ ++ ++ ++ ++ +L
Sbjct: 205 AIDLRGISG-----------LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILT 253
Query: 1751 MLLFFIFAALGVELF----------GDLECDET--------------------------- 1773
+ +FA +G++LF D+ +ET
Sbjct: 254 IFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNG 313
Query: 1774 ----HPCEGL----------GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQES 1819
H +G + +F +F AFL+LFR+ T D+W + + TLR +
Sbjct: 314 SDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK-- 371
Query: 1820 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK------EAKE---------- 1863
I I+FV + F LVN+++AV+ EE N+ EAKE
Sbjct: 372 ------IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEML 425
Query: 1864 --EAELEAELELEMKTLSPQPHSPLGSP-------FLWPGVEGPDSPDSPKPGA------ 1908
E E+ A L ++ +L SPL S + P V + D+ P +
Sbjct: 426 RKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQR 485
Query: 1909 ----LHPAAHARSASHFSLEH-------------PTDRQLFDTISLLIQGSLEWELKLMD 1951
L A+ R ASH S+ H TD +F +GSL
Sbjct: 486 RMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSL-------- 537
Query: 1952 ELAGPGGQPSAFPSAPSLGGSDP-------QMQPHPTELPGPDLLTV 1991
L G GQ P +P S+P + QP PT P + V
Sbjct: 538 LLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDV 584
Score = 87.4 bits (215), Expect = 1e-16
Identities = 68/282 (24%), Positives = 131/282 (46%), Gaps = 45/282 (15%)
Query: 735 TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792
T +IV+ +F I+ IL+++ S+ E Y +Q + LE ++ VFT +F EMLL
Sbjct: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
Query: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847
K + YG Y N + D +IV IS+ + + + + LRT R +R L+ +
Sbjct: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
Query: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898
++ + L+ + ++ ++ ++F IFSI+G++LF KF + DG+
Sbjct: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
Query: 899 TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935
++ + K NFD++ + + Q+ T + W ++Y + S
Sbjct: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
Query: 936 ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
+ + LYF+ + FG + NL V ++++ F ++
Sbjct: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQK 1425
Score = 84.3 bits (207), Expect = 1e-15
Identities = 65/271 (23%), Positives = 119/271 (43%), Gaps = 35/271 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM+ I +N ++M +E +Q EE T L N F ++F E ++K+
Sbjct: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848
+ Y N +N+FD ++VV+S+ ++ V+R R+ R+L+L+R
Sbjct: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
++ L LM ++ + +LL L +FI+SI GM F R + D NF +
Sbjct: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
Query: 909 LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948
+++ +FQI T W+ +L G + + ++F +
Sbjct: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
Query: 949 TFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +A+++E F E S
Sbjct: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLS 1737
Score = 65.9 bits (159), Expect = 5e-10
Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M++I LN +T+ + E ++ +IL + F A F E V+KM AL
Sbjct: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
Query: 143 GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193
++ Y + WN DF +V+ + L +S L+++ F +R R+ R LR I
Sbjct: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
Query: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
+R L+ L+ +LP L N+ LL F V FI+ I G+
Sbjct: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
Score = 63.9 bits (154), Expect = 2e-09
Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)
Query: 47 EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101
E+E P L + YL D P L+T V +P+ E L I++N + + M
Sbjct: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
Query: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161
E +LQ + FF EMV K++A F Y WN D IV
Sbjct: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
Query: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221
+LE + + S S +R+ R+LR + P++ L+ ++ +++ LGN+ ++ +
Sbjct: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
Query: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250
F+F +VG QL RN +N S P
Sbjct: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 419 bits (1077), Expect = e-116
Identities = 321/1164 (27%), Positives = 553/1164 (47%), Gaps = 129/1164 (11%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG S + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIM 1492
+G+ N T NKS C + W + K NFDN+G ++L +
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV---------- 1415
Query: 1493 YDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA 1552
++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1416 --------YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1467
Query: 1553 RRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHY 1612
EE +KK N M S+ KP ++++ + + T
Sbjct: 1468 FMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1511
Query: 1613 LDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF E + KL A +F
Sbjct: 1512 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYF 1569
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+ WN D +V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1570 TNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRT 1627
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1791
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F +
Sbjct: 1628 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANS 1682
Query: 1792 FLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQ 1839
L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1683 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1742
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKE 1863
++VN+ IA+++++ + +E+ E
Sbjct: 1743 LIVVNMYIAIILENFSVATEESTE 1766
Score = 125 bits (313), Expect = 6e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
Query: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
Query: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
+ ++I VLN+F+ +++ +F
Sbjct: 920 LLVMVIGNLVVLNLFLALLLSSF 942
Score = 122 bits (305), Expect = 5e-27
Identities = 108/387 (27%), Positives = 170/387 (43%), Gaps = 88/387 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLE-GWVDI 359
+Y N+ S +N GE K +NFDN+G ++A+ QV + W
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVYEEQPQW--- 1422
Query: 360 MYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRF 416
++ Y +IYF++ II GSFF +NL + VI F++ K++ + M E++ ++
Sbjct: 1423 ------EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1476
Query: 417 LSNASTLASFSEPGSCYEELLKYLVYI 443
+ L S L KY +I
Sbjct: 1477 YNAMKKLGSKKPQKPIPRPLNKYQGFI 1503
Score = 120 bits (301), Expect = 2e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 104 bits (260), Expect = 9e-22
Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1566 KRRNLMLDDV 1575
+ L + V
Sbjct: 444 EHEALTIRGV 453
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1506 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1565
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1566 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1624
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1625 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1680
Query: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1681 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1740
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1741 SFLIVVNMYIAIILENFSVATEESTEPLS 1769
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
Query: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 9e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1512 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1564
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1565 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1623
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1624 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1662
Score = 32.7 bits (73), Expect = 4.3
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 413 bits (1061), Expect = e-114
Identities = 315/1164 (27%), Positives = 550/1164 (47%), Gaps = 144/1164 (12%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVS 1082
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1083 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1140
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1191
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1251
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1252 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1304
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1305 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1364
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIM 1492
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DIM
Sbjct: 1365 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424
Query: 1493 YDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA 1552
Y +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484
Query: 1553 RRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHY 1612
EE +KK N M S+ KP ++++ + + T
Sbjct: 1485 FMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1528
Query: 1613 LDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF + ++ +++F
Sbjct: 1529 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGTVLSDII----QKYF 1583
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1584 -------------------------------FSPTLFRVIRLARIGRILRLIRGAKGIRT 1612
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1791
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F +
Sbjct: 1613 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANS 1667
Query: 1792 FLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQ 1839
L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1668 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1727
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKE 1863
++VN+ IA+++++ + +E+ E
Sbjct: 1728 LIVVNMYIAIILENFSVATEESTE 1751
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520
Score = 125 bits (313), Expect = 6e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
Query: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
Query: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
+ ++I VLN+F+ +++ +F
Sbjct: 920 LLVMVIGNLVVLNLFLALLLSSF 942
Score = 120 bits (301), Expect = 2e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 116 bits (291), Expect = 2e-25
Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)
Query: 1566 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1611
++R L V+ S S +C P ++ ++ R L+ C
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717
Query: 1612 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1791
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
Query: 1792 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
Query: 1852 KHLEESNKEAKEEAELEAELELEM 1875
N A +E L+L +
Sbjct: 940 SSFSADNLTAPDEDREMNNLQLAL 963
Score = 108 bits (269), Expect = 8e-23
Identities = 85/326 (26%), Positives = 152/326 (46%), Gaps = 40/326 (12%)
Query: 1599 RFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYIFTVIFVL 1656
R R +H+ + + FI +I L+ +A E + ++ + + L+ + +FT +FVL
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1251
Query: 1657 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
E + K VA+GF+++F + W LD IV +S++ + + P I+ +R LR
Sbjct: 1252 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP-----IKSLRTLRA 1306
Query: 1717 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF----------- 1765
R L+ L GMR +++ ++ A+P + N+ L+ ++ + IF+ +GV LF
Sbjct: 1307 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1366
Query: 1766 -GDLECDET-----HPCEGLGR---------HATFRNFGMAFLTLFRVSTGDNWNGIMKD 1810
GDL + T CE L F N G +L L +V+T W IM
Sbjct: 1367 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1426
Query: 1811 TL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE---- 1864
+ R +++ + IYFV F++ F +N+ I V++ + + K+ +
Sbjct: 1427 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1486
Query: 1865 AELEAELELEMKTL-SPQPHSPLGSP 1889
E + + MK L S +P P+ P
Sbjct: 1487 TEEQKKYYNAMKKLGSKKPQKPIPRP 1512
Score = 104 bits (260), Expect = 9e-22
Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1566 KRRNLMLDDV 1575
+ L + V
Sbjct: 444 EHEALTIRGV 453
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
Query: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 62.0 bits (149), Expect = 7e-09
Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 49/261 (18%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F +L ++
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGTVLSDIIQK- 1581
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVL 858
Y +P +F V+R R+ R+L+L+R ++ L L
Sbjct: 1582 ---YFFSP-TLF--------------------RVIRLARIGRILRLIRGAKGIRTLLFAL 1617
Query: 859 MKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQ 918
M ++ + +LL L +FI+SI GM FA + + D NF + +++ +FQ
Sbjct: 1618 MMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFANSMLCLFQ 1673
Query: 919 ILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTFGNYVLFNL 958
I T W+ +L G + + L+F + ++ N+
Sbjct: 1674 ITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNM 1733
Query: 959 LVAILVEGFQAEEISKREDAS 979
+AI++E F E S
Sbjct: 1734 YIAIILENFSVATEESTEPLS 1754
Score = 41.2 bits (95), Expect = 0.012
Identities = 23/59 (38%), Positives = 33/59 (55%)
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
F +R R+ R LR I +R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1589 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1647
Score = 32.7 bits (73), Expect = 4.3
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 345 bits (884), Expect = 4e-94
Identities = 198/607 (32%), Positives = 338/607 (55%), Gaps = 45/607 (7%)
Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
Query: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1444
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
Query: 1445 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ EE
Sbjct: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEE--- 1328
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
+KK N M S+ KP ++ + LV + TS D+ I +
Sbjct: 1329 ---QKKYYNAM----------KKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISL 1375
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
I LN+++M E Y QP+ + L N++F VIF LE + K+ A + +F + WN D
Sbjct: 1376 IILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDC 1434
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
+VLLSI+ + +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +L
Sbjct: 1435 VVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSL 1494
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
P + N+GLL L+ FI+A LG+ F + +P G+ F+ F + L LF++ST
Sbjct: 1495 PSLFNIGLLLFLIMFIYAILGMNWFS-----KVNPESGIDDIFNFKTFASSMLCLFQIST 1549
Query: 1801 GDNWNGIMKDTLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEE 1856
W+ ++ LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++
Sbjct: 1550 SAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNT 1609
Query: 1857 SNKEAKE 1863
+ +E+++
Sbjct: 1610 ATEESED 1616
Score = 130 bits (328), Expect = 1e-29
Identities = 77/276 (27%), Positives = 145/276 (52%), Gaps = 15/276 (5%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
Query: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
Query: 955 LFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVD 990
+ NL +A+L+ F EE + + + + +QL +D
Sbjct: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALD 837
Score = 116 bits (290), Expect = 3e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
Query: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
Query: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
Query: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
+S D + E D C + +EN + C G G C + YE
Sbjct: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
Query: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
Query: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Score = 114 bits (285), Expect = 1e-24
Identities = 83/349 (23%), Positives = 166/349 (47%), Gaps = 55/349 (15%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
Query: 1437 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1467
C D +NI+N S C+ E + + Y
Sbjct: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
Query: 1468 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1524
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
Query: 1525 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRRNLML 1572
+F+++N+ + VV + + ++ E EA+ + + ++L K+ + ++
Sbjct: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALV 436
Score = 103 bits (258), Expect = 2e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1378
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
Query: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
Query: 1439 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1498
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
Query: 1499 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
Score = 102 bits (255), Expect = 3e-21
Identities = 71/266 (26%), Positives = 129/266 (48%), Gaps = 22/266 (8%)
Query: 1609 TSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFR 1668
T + +L IT I +N V +AMEH++ ++ L I N +FT IF+ E K++A
Sbjct: 575 TDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPY 634
Query: 1669 RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVG 1728
+F+ WN D + LLS + + + S P +R R+ RV KL K
Sbjct: 635 HYFRRGWNIFDSIVALLSFADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPT 686
Query: 1729 MRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--------DLECDETHPCEGLG 1780
+ L+ + ++ +G+L ++ +++ FIF+ +G++LFG C+ T P
Sbjct: 687 LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCL 746
Query: 1781 RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1840
RH +F +FL +FR+ G+ W + + +C QE+ ++ + I F+ + +
Sbjct: 747 RHWHMGDFWHSFLVVFRILCGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKL 800
Query: 1841 VLVNVVIAVLMKHLEESNKEAKEEAE 1866
V++N+ IA+L+ + E E
Sbjct: 801 VVLNLFIALLLNSFSNEERNGNLEGE 826
Score = 96.3 bits (238), Expect = 3e-19
Identities = 71/265 (26%), Positives = 130/265 (49%), Gaps = 28/265 (10%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
Query: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
Query: 957 NLLVAILVEGFQAEEISKREDASGQ 981
N+ +A+++E F + ED G+
Sbjct: 1597 NMYIAVILENFNT-ATEESEDPLGE 1620
Score = 91.7 bits (226), Expect = 8e-18
Identities = 65/279 (23%), Positives = 132/279 (47%), Gaps = 41/279 (14%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
Query: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
Query: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
Query: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
Query: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
+S +YF+ + FG++ NL + ++++ F ++
Sbjct: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQ 1315
Score = 88.6 bits (218), Expect = 7e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
Query: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 1594 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1653
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
Query: 1654 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1705
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
Query: 1706 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
Query: 1766 ------------------------------------------GDLECDETHPCEGLG--- 1780
G+ C + C+
Sbjct: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
Query: 1781 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1838
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
Query: 1839 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1878
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
Score = 86.3 bits (212), Expect = 3e-16
Identities = 66/284 (23%), Positives = 135/284 (47%), Gaps = 28/284 (9%)
Query: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
Query: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
Query: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
Query: 1452 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1511
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
Query: 1512 WMLLYFISFLLIVAFFVLNMFVGVVVENF-HKCRQHQEEEEARR 1554
++ FI +I VLN+F+ +++ +F ++ R E EAR+
Sbjct: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARK 829
Score = 84.7 bits (208), Expect = 9e-16
Identities = 54/251 (21%), Positives = 114/251 (45%), Gaps = 52/251 (20%)
Query: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
Query: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
Query: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
CK S + + P+ K
Sbjct: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
Query: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
Query: 960 VAILVEGFQAE 970
+A++ ++ +
Sbjct: 396 LAVVTMAYEEQ 406
Score = 71.2 bits (173), Expect = 1e-11
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
Score = 56.2 bits (134), Expect = 4e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
Score = 51.6 bits (122), Expect = 9e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
Query: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
Score = 33.9 bits (76), Expect = 1.9
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
Query: 399 SETKQRESQLMREQR 413
S ++R L E R
Sbjct: 815 S-NEERNGNLEGEAR 828
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 330 bits (847), Expect = 8e-90
Identities = 205/676 (30%), Positives = 359/676 (53%), Gaps = 62/676 (9%)
Query: 1216 DPPLDGDDADDEGNLSKGERVRAWIR----ARLPACCLERDSWSAYIFPPQSRFRLLCHR 1271
D PL G+ + E + A R C + +S I+ R C++
Sbjct: 1120 DNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIW---WNIRKTCYK 1176
Query: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
I+ H F+ ++++I L+ +A E I+ +I L ++ IFT +F+ EM +K +A
Sbjct: 1177 IVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA 1236
Query: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
G+ + Y ++W LD L+V +S++ ++ + + G LG ++ LR LR LRPLR
Sbjct: 1237 YGY----KTYFTNAWCWLDFLIVDVSLVTLVANTL---GYSDLGPIKSLRTLRALRPLRA 1289
Query: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED------ 1445
+SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF+ C
Sbjct: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFP 1349
Query: 1446 TRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
+ N+S+C + RW K NFDN+G +SL +A+ GW IMY +D+V
Sbjct: 1350 ASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVN 1409
Query: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
VD+QP ++ +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ EE
Sbjct: 1410 VDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE--- 1466
Query: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
+KK N M S+ KP ++ + + L T+ D+ I +
Sbjct: 1467 ---QKKYYNAM----------KKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVL 1513
Query: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
I LN+VTM +E Q Q + E L N +F ++F E V KL++ +F WN D
Sbjct: 1514 ICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDF 1572
Query: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
+V++SI+G+ L ++ + ++PT+ R++R+ RI R+L+L+K A G+R LL +M +L
Sbjct: 1573 VVVIISIVGMFLADL--IETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSL 1630
Query: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
P + N+GLL L+ FI+A G+ F ++ + +G+ F FG + + LF+++T
Sbjct: 1631 PALFNIGLLLFLVMFIYAIFGMSNFAYVKKE-----DGINDMFNFETFGNSMICLFQITT 1685
Query: 1801 GDNWNGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVI 1847
W+G++ L DCD E C N + YFVS+++ + V+VN+ I
Sbjct: 1686 SAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYI 1745
Query: 1848 AVLMKHLEESNKEAKE 1863
AV++++ + +E+ E
Sbjct: 1746 AVILENFSVATEESTE 1761
Score = 150 bits (379), Expect = 1e-35
Identities = 202/932 (21%), Positives = 370/932 (39%), Gaps = 221/932 (23%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV- 796
KI+ F IM IL N + M + P + T +E + FT ++ E L+K+L
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMN---NPPDWTKNVEYT---FTGIYTFESLVKILAR 174
Query: 797 ---YGPFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
G F ++++P+N D V++V + + E V G +S LRTFR++R LK + +P L+
Sbjct: 175 GFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLK 232
Query: 853 RQLVVLMKTMDNVA------TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKN- 905
+ L++++ ++ FC+ + I + +G C S + +TL N
Sbjct: 233 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNT 292
Query: 906 ---------------------------------------------------FDSLLWAIV 914
FD+ WA +
Sbjct: 293 LESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFL 352
Query: 915 TVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISK 974
+F+++TQ+ W + + + ++F+ ++ G++ L NL++A++ ++ + +
Sbjct: 353 ALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412
Query: 975 REDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKS 1034
E+A + Q +D + ++E+ + E+ +R+S
Sbjct: 413 IEEAKQKELEFQQMLDRLKKEQEEAEA-------------------IAAAAAEYTSIRRS 453
Query: 1035 LLPPLIIHTAATPMSLPKSTST-------------GLGEALGPASRRTSSSG-------S 1074
+ L ++ T KS GE G A + + S S
Sbjct: 454 RIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKS 513
Query: 1075 AEPGAAHEMKSPPSARSSPH-SPWSAASS-WTSRRSSRNSLGRAPSLKRRSPSGERRSLL 1132
G ++ S+P+ SP S S +++RRSSR SL
Sbjct: 514 FHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFS----------------F 557
Query: 1133 SGEGQESQDEEESSEEERASPAGSDHRHRGSL----EREAKSSFDLPDTLQVPGLHRTAS 1188
G G++ E E +++E S G + RGSL + + S ++ + P +
Sbjct: 558 KGRGRDIGSETEFADDEH-SIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPV-- 614
Query: 1189 GRGSASEHQDCNG--KSASGRLARAL-----------------RPDDPPLDGDDADDEGN 1229
G DCNG GR A L R L +D ++ N
Sbjct: 615 -NGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPN 673
Query: 1230 LSKGERVRAWIRARLPACCLERDSWSAYIFPPQ-----------------SRFRLLCHRI 1272
L R RA RA + +E S PP +F+ + I
Sbjct: 674 L----RQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFI 729
Query: 1273 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE-RIFLTLSNYIFTAVFLAEMTVKVVA 1331
+ D + + I LN + +AME P + E + L + N +FT +F AEM +K++A
Sbjct: 730 VMDPFVDLAITICIVLNTLFMAMEH---HPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIA 786
Query: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
+ Y + WN+ D L+V +S++++ ++ V L VLR R LR ++
Sbjct: 787 MD----PYEYFQVGWNIFDSLIVTLSLVELFLADVEG--------LSVLRSFRLLRVFKL 834
Query: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF---VCQGEDTRN 1448
L ++++ + +S+ +GN+ ++ IF ++G+QLF GK + VC+ D
Sbjct: 835 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIND--- 890
Query: 1449 ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMN 1508
DC RW H +F + L+ VL + W++ M+D ++ G
Sbjct: 891 -----DCTLP--RW--HMNDFFH--SFLIVFRVLCGE--WIETMWDCMEVAG-------- 929
Query: 1509 HNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540
L+ ++ ++I VLN+F+ +++ +F
Sbjct: 930 -QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
Score = 145 bits (365), Expect = 6e-34
Identities = 82/244 (33%), Positives = 140/244 (57%), Gaps = 7/244 (2%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + I I I++NTL M +E+H EE N L I N+VFT +FA EM+LKL+
Sbjct: 729 IVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD 788
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVL 858
P+ Y + +NIFD +IV +S+ E+ GLSVLR+FRL+RV KL + P L + ++
Sbjct: 789 PYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKII 848
Query: 859 MKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRKNFDSLLWAIV 914
++ + ++L + +FIF+++GM LFG + D TLP R + + + +
Sbjct: 849 GNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RWHMNDFFHSFL 907
Query: 915 TVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIS 973
VF++L E W + +++ M + + + ++ +M GN V+ NL +A+L+ F ++ ++
Sbjct: 908 IVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLT 966
Query: 974 KRED 977
E+
Sbjct: 967 AIEE 970
Score = 140 bits (352), Expect = 2e-32
Identities = 114/378 (30%), Positives = 177/378 (46%), Gaps = 92/378 (24%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128
R C + V + WFE +L+ILL+ L EDI + ++ +I+ + D IF + F
Sbjct: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAF----EDIYIERKKTIKIILEYADKIFTYIF 1226
Query: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181
+EM++K +A +G K Y + W LDF IV +A L YS DL + ++RT
Sbjct: 1227 ILEMLLKWIA---YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYS-DLGPIK--SLRT 1280
Query: 182 VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG
Sbjct: 1281 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG------ 1334
Query: 242 FLPENFSLPLSVDLERYYQTEN-EDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
++Y+ N D S F SQ P
Sbjct: 1335 ---------------KFYECINTTDGSRFPASQV---------------------PNRSE 1358
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+ N S N V W +NFDN+G ++++ QV T +GW IM
Sbjct: 1359 CFALMNVSQN---VRWKNL--------------KVNFDNVGLGYLSLLQVATFKGWTIIM 1401
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ +S Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1402 YAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1461
Query: 408 LMREQRVRFLSNASTLAS 425
M E++ ++ + L S
Sbjct: 1462 FMTEEQKKYYNAMKKLGS 1479
Score = 130 bits (326), Expect = 2e-29
Identities = 112/480 (23%), Positives = 202/480 (42%), Gaps = 62/480 (12%)
Query: 57 APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116
A + LS S R ++ + + F + M IL NC+ + M P +
Sbjct: 102 ATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPD----------W 151
Query: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175
+ + + E +VK++A G G+ +L D WN LDF +++ L ++L NVS
Sbjct: 152 TKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVS 211
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+RT RVLR L+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G
Sbjct: 212 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
L+++CF + + ++E + F + ++ +
Sbjct: 270 NLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALL--------------- 314
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
CG ++ TCV + NP G +FD +A++A+F+++T +
Sbjct: 315 --CGFSTDSGQCPEGYTCVKIGR----------NPDYGYTSFDTFSWAFLALFRLMTQDY 362
Query: 356 WVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVR 415
W ++ + A I+F+++I +GSF++INL L V+A + E Q + +++ +
Sbjct: 363 WENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELE 422
Query: 416 FLSNASTLASFSEPGSC-------YEELLKYLVYILRKAARRLAQVS---------RAAG 459
F L E Y + + + L +++ +++S R
Sbjct: 423 FQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKK 482
Query: 460 VRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASP 519
LSS G E S S RR S H V H H L P SP
Sbjct: 483 KNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEK------RLSTPNQSP 536
Score = 114 bits (286), Expect = 9e-25
Identities = 88/357 (24%), Positives = 159/357 (44%), Gaps = 75/357 (21%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P S R + +I+ H +F +++ I NCI + M P + E Y
Sbjct: 107 YMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVE--------YT 158
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FT ++ E VK++A G+C GE +LR WN LD ++++ + + V+ LG
Sbjct: 159 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---------LGN 209
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
+ LR R LR L+ IS GLK +V L+ S+K + +++++ +F ++G+QLF G
Sbjct: 210 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269
Query: 1437 K--------------------------------FFVCQGEDTRNI----TNKSDCAEASY 1460
F+ +G + T+ C E Y
Sbjct: 270 NLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPE-GY 328
Query: 1461 RWVRHKYN-------FDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWM 1513
V+ N FD A ++LF L ++D W ++ L A G
Sbjct: 329 TCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG----------KTY 378
Query: 1514 LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRRE---EKRLRRLEKKR 1567
+++F+ + + +F+++N+ + VV + + Q EEA+++E ++ L RL+K++
Sbjct: 379 MIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQ 434
Score = 114 bits (284), Expect = 1e-24
Identities = 82/279 (29%), Positives = 137/279 (49%), Gaps = 27/279 (9%)
Query: 1590 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
C PY+ +F+ ++ + ++DL IT I LN + MAMEH+ + L I N +
Sbjct: 715 CSPYWI---KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLV 771
Query: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
FT IF E V KL+A +FQ WN D IV LS++ + L ++E +
Sbjct: 772 FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG----------LS 821
Query: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1766
++R R+ RV KL K + L+ + ++ +GNL L+ ++ FIFA +G++LFG
Sbjct: 822 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 881
Query: 1767 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1825
+ C C H +F +FL +FRV G+ W +T+ DC + +
Sbjct: 882 KECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQA 931
Query: 1826 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1864
+ I ++ ++ V++N+ +A+L+ N A EE
Sbjct: 932 MCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE 970
Score = 101 bits (252), Expect = 7e-21
Identities = 84/345 (24%), Positives = 155/345 (44%), Gaps = 46/345 (13%)
Query: 672 RAGAGEVELADREMPDSDSEAVYE-FTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWR 730
R+ + E D +P EA E D + D RR + E +W
Sbjct: 1110 RSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWN 1169
Query: 731 LICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFAL 788
I T KIV+ +F I++ IL+++ ++ E Y E+ + + LE ++ +FT +F L
Sbjct: 1170 -IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFIL 1228
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG--GLSVLRTFRLMRVLKLVR 846
EMLLK + YG Y N + D +IV +S+ +V G L +++ R +R L+ +R
Sbjct: 1229 EMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLR 1288
Query: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGDTL 900
L + VV L+ + ++ ++ ++F IFSI+G++LF KF + DG
Sbjct: 1289 ALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRF 1348
Query: 901 PD------------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST 936
P + NFD++ +++ Q+ T + W ++Y + S
Sbjct: 1349 PASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSV 1408
Query: 937 ----------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
S + +YF+ + FG++ NL + ++++ F ++
Sbjct: 1409 NVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQK 1453
Score = 91.3 bits (225), Expect = 1e-17
Identities = 74/273 (27%), Positives = 124/273 (45%), Gaps = 40/273 (14%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V ++ F IM+ I +N ++M +E Q + +T L N+VF LF E +LKL+
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847
+ Y +NIFD V+V+IS IVG L V+R R+ R+L+LV+
Sbjct: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
Query: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907
++ L LM ++ + +LL L +FI++I GM FA + D + D NF+
Sbjct: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKKEDGINDMFNFE 1671
Query: 908 SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946
+ +++ +FQI T W+ +L G S YF++
Sbjct: 1672 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVS 1731
Query: 947 LMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
+ V+ N+ +A+++E F E S
Sbjct: 1732 YIIISFLVVVNMYIAVILENFSVATEESTEPLS 1764
Score = 87.8 bits (216), Expect = 1e-16
Identities = 80/335 (23%), Positives = 140/335 (41%), Gaps = 92/335 (27%)
Query: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
++LVH L + I I N + M M + + K Y FT I+ ES+
Sbjct: 121 KILVHSL-----FSMLIMCTILTNCIFMTMNNPP------DWTKNVEYTFTGIYTFESLV 169
Query: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
K++A GF F +D WN LD +++ + L E +N + +R R+
Sbjct: 170 KILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALRTFRV 218
Query: 1717 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL------- 1768
R LK + + G++ ++ ++Q++ ++ ++ +L + +FA +G++LF G+L
Sbjct: 219 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278
Query: 1769 --------------------------------------------ECDETHPCEGLGR--- 1781
+C E + C +GR
Sbjct: 279 SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338
Query: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
+ +F F AFL LFR+ T D W + + TLR + I+FV +
Sbjct: 339 YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM--------IFFVVVIFLGS 390
Query: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELE 1874
F L+N+++AV+ EE N+ EEA+ + ELE +
Sbjct: 391 FYLINLILAVVAMAYEEQNQANIEEAK-QKELEFQ 424
Score = 59.7 bits (143), Expect = 3e-08
Identities = 46/177 (25%), Positives = 93/177 (52%), Gaps = 15/177 (8%)
Query: 78 VCNPWFERISMLVILLNCVTLGM-FRPCEDIACDSQRCRILQAFDDFIFA-FFAVEMVVK 135
V +P+ + + I+LN + + M P ++ + + A + +F FA EMV+K
Sbjct: 730 VMDPFVDLAITICIVLNTLFMAMEHHPM------TEEFKNVLAIGNLVFTGIFAAEMVLK 783
Query: 136 MVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRTVRVLRPLRAINRV 194
++A+ + Y WN D IV ++E L D++ +S +R+ R+LR +
Sbjct: 784 LIAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVEGLS--VLRSFRLLRVFKLAKSW 838
Query: 195 PSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250
P++ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+ + C + ++ +LP
Sbjct: 839 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 895
Score = 55.8 bits (133), Expect = 5e-07
Identities = 46/164 (28%), Positives = 73/164 (44%), Gaps = 15/164 (9%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V N F+ M++I LN VT+ + E +L + F E V+K++
Sbjct: 1501 VTNQAFDISIMVLICLNMVTMMV----EKEGQSQHMTEVLYWINVVFIILFTGECVLKLI 1556
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRA 190
+L + Y WN DF +VI ++ L + F +R R+ R LR
Sbjct: 1557 SL----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRL 1612
Query: 191 INRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+ +R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1613 VKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
Score = 33.9 bits (76), Expect = 1.9
Identities = 19/97 (19%), Positives = 40/97 (41%), Gaps = 21/97 (21%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374
NF+ G + I +FQ+ T GW ++ ++++ + Y
Sbjct: 1669 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFY 1728
Query: 375 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411
F+ II+ ++N+ + VI FS + ++ + E
Sbjct: 1729 FVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 329 bits (843), Expect = 2e-89
Identities = 228/795 (28%), Positives = 411/795 (51%), Gaps = 78/795 (9%)
Query: 1140 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1199
++EEE E ++ + S + + +E+ A + +++ + TA G + +
Sbjct: 767 KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823
Query: 1200 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1258
+ + ++ P+ P G++ ++E + G R R L + SA+ I
Sbjct: 824 DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query: 1259 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1318
F +RFRL CHRI+ +F +++L I L+ I++A E P + S L ++Y+FT
Sbjct: 883 FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941
Query: 1319 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1378
++F E+ +K+ A G + ++ R+ +N+LD L+V +S+I + + + +++
Sbjct: 942 SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995
Query: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
+LR+LR LRPLR I+RA+GLK VV+ + +++ IGNIV++ +F +GVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1439 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1486
+ C + IT K + W K++FDN+ A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1487 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1546
GW +++Y +D+ D+ PI N+ + ++FI +++I+AFF++N+FVG V+ F Q
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171
Query: 1547 QEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHH 1606
Q E+E + E L+K +R + A +A+ Y ++ + V +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCV-----------EYALKARPLRRYIPKNQHQYKVWY 1214
Query: 1607 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1666
+ S Y + + +I LN + +AM+HY Q + A+ I N +FT +F +E + KL+AF
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 1667 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1726
+ +F D WN D IV+ SI+ I + EVN + + I R+ R+ R++KLL
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEENSRISITFFRLFRVMRLVKLLSRG 1332
Query: 1727 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1786
G+R LL T +++ + + LL ++LFFI+A +G+++FG + ++T + R+ F+
Sbjct: 1333 EGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQ 1389
Query: 1787 NFGMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFV 1835
F A L LFR +TG+ W IM + + C ES N+ + YF+SF
Sbjct: 1390 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFY 1449
Query: 1836 LTAQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTL 1878
+ F+++N+ +AV+M HL+E + A+ + E + ++ L++ TL
Sbjct: 1450 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 1509
Query: 1879 SPQPHSPLGSPFLWP 1893
+ PLG L P
Sbjct: 1510 LRRIQPPLGFGKLCP 1524
Score = 247 bits (631), Expect = 8e-65
Identities = 188/698 (26%), Positives = 332/698 (47%), Gaps = 98/698 (14%)
Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1324
R C I+ K F+ ++L+ IF NC+ +A+ P D +A L Y+F +F E
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173
Query: 1325 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1377
+KV+A G F AYLR+ WN+LD ++V++ + ++ + + G LG +
Sbjct: 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233
Query: 1378 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1437
+ LR R LRPLR++S L++V+ +++ ++ P+ +I ++ II+ I+G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 1438 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1476
C + D + S CA + W K+ NFDN A+
Sbjct: 294 MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353
Query: 1477 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1536
+++F + +GW D++Y DAVG D W +YF++ ++I +FFVLN+ +GV+
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404
Query: 1537 VENFHKCRQH-------QEEEEARRREEKRLRRL-------------------EKKRRNL 1570
F K R+ Q+ E ++ EE L E+K RN+
Sbjct: 405 SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464
Query: 1571 MLD---------------DVIASGSSASAA---SEAQCKPYYSDYSRF-RLLVHHLCTSH 1611
+ D+ A A S+++ Y+ ++RF R S+
Sbjct: 465 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 1612 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
+ ++ LN +T+A EHY QP L E N +F E + K+ + G + +F
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+N+ D +V I+ L E ++ ++P I ++R +R+ R+ K+ + +
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1790
L+ +++ ++ + +L LL L IF+ LG++LF G DE R +TF NF
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694
Query: 1791 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1850
+ LT+F++ TG++WN +M D + S + ++ IYF+ + ++L+NV +A+
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752
Query: 1851 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
+ +L ES A++E E E E + +T SP+ L
Sbjct: 753 VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790
Score = 148 bits (374), Expect = 5e-35
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C+ V FE I +L I NCV L ++ P + ++ L+ + F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
E +K++A G+ F YL + WN LDF IV+ G+ L+ +
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+R RVLRPLR ++ VPS+++++ ++ + L ++ LL FV I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
+ C+ E I P E+ C + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
C Q T C G P G NFDN +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
W D++Y+V DA + +IYF+ LII+GSFF++NL L V++ +FS+ +++ + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424
Query: 410 REQR 413
RE++
Sbjct: 425 REKQ 428
Score = 145 bits (367), Expect = 3e-34
Identities = 100/313 (31%), Positives = 159/313 (50%), Gaps = 22/313 (7%)
Query: 674 GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
G E + + MP S++E+V T++ D+ + + L S +WR
Sbjct: 455 GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510
Query: 732 -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
C R V S F ++ + +NTL++ E++ QP LT + +N +LF E
Sbjct: 511 RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570
Query: 790 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
MLLK+ G Y + +N FD +V + E + + G+SVLR RL+R+ K+
Sbjct: 571 MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM LFG KF + + R
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
FD+ +++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+
Sbjct: 688 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 959 LVAILVEGFQAEE 971
+AI V+ E
Sbjct: 748 FLAIAVDNLADAE 760
Score = 110 bits (276), Expect = 1e-23
Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
+ +P P + FF S ++R R C R V + F + + ILL+ ++L P +
Sbjct: 870 KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
S R IL D + F +E+++KM A G F K + + +N LD +V ++ +
Sbjct: 927 --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984
Query: 168 SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
+ ++ + R +RVLRPLRAINR ++ +V + + +GN++++ + F+F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 227 IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
+GVQL+ G L + + S + + Y T + E QPR
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089
Query: 287 TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
+W E++ F +FDN+ A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107
Query: 347 IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
+F V T EGW +++Y +D+H+ YN+ I+FI+ II+ +FFM+N+ + +
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 397 QFSETKQRE 405
F E ++E
Sbjct: 1168 TFQEQGEQE 1176
Score = 108 bits (271), Expect = 5e-23
Identities = 70/256 (27%), Positives = 132/256 (51%), Gaps = 29/256 (11%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V+S YF + + IL+NT+ + ++++ Q A+ I N++FT LF +EM+LKL+ +
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIV------GQQGGGLSV--LRTFRLMRVLKLVRFLPA 850
P Y + +N FD +IVV S+ +I ++ +S+ R FR+MR++KL+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L +K+ + +L+++ FI++++GM +FG K A D + NF +
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTEINRNNNFQTFP 1392
Query: 911 WAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFG 951
A++ +F+ T E W ++ M SS+A YFI+
Sbjct: 1393 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLC 1452
Query: 952 NYVLFNLLVAILVEGF 967
+++ NL VA++++ F
Sbjct: 1453 AFLIINLFVAVIMDNF 1468
Score = 103 bits (257), Expect = 2e-21
Identities = 92/343 (26%), Positives = 149/343 (43%), Gaps = 79/343 (23%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ I Y PE+ +NA LE +F +F +E LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178
Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
+ YG P Y++N +N+ D +IVV+ ++ + G +G G V LR
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238
Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
FR++R L+LV +P+LQ L ++K M + +L++ I I++I+G+ LF K
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298
Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
+ D P NFD+ +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358
Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKR-- 975
+T E W VLY A W +YF+ L+ G++ + NL++ +L F E +
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query: 976 -------------EDASGQLSCIQL--PVDSQGGDANKSESEP 1003
ED G L I +D + D E +P
Sbjct: 419 GDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKP 461
Score = 87.4 bits (215), Expect = 1e-16
Identities = 104/450 (23%), Positives = 194/450 (43%), Gaps = 79/450 (17%)
Query: 595 TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
TS E +EK ++A ++ P L P S + +E +S G + KI+
Sbjct: 763 TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
L+ + D PY GE + + EMP + L + H +
Sbjct: 823 MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868
Query: 712 RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
+ P+A + + +RL C +IV+ F I+ IL++++S+ E Q
Sbjct: 869 EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 769 EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
N L ++ VFTS+F LE++LK+ YG F + +N +NI D ++V +S+
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984
Query: 824 GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
G Q ++V++ R++RVL+ +R L + + + V ++T+ N+ LL F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041
Query: 878 IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
+F+ +G+ LF CK + + +DG+ + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101
Query: 910 LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
L A++ +F + T E W ++LY + S + +++FI + + + N+
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161
Query: 960 VAILVEGFQ---AEEISKREDASGQLSCIQ 986
V ++ FQ +E E Q C++
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELDKNQRQCVE 1191
Score = 65.9 bits (159), Expect = 5e-10
Identities = 47/172 (27%), Positives = 83/172 (48%), Gaps = 20/172 (11%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V + +FE + ++ILLN + L M Q C A + F F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN-------VSFSAVRTVRVLRP 187
K++A F K Y D WN D IV+ +++ ++ N +S + R RV+R
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
++ ++R +R L+ + + L V LL +FFI+ ++G+Q++ + N
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C V + F + + ++ LN +T+ E + + + + A F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
EM++KM +LG+ + Y +NR D F+V G+LE L + + S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 46.2 bits (108), Expect = 4e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
L + ++ + S E+ + + AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 329 bits (843), Expect = 2e-89
Identities = 228/795 (28%), Positives = 411/795 (51%), Gaps = 78/795 (9%)
Query: 1140 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1199
++EEE E ++ + S + + +E+ A + +++ + TA G + +
Sbjct: 767 KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823
Query: 1200 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1258
+ + ++ P+ P G++ ++E + G R R L + SA+ I
Sbjct: 824 DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query: 1259 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1318
F +RFRL CHRI+ +F +++L I L+ I++A E P + S L ++Y+FT
Sbjct: 883 FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941
Query: 1319 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1378
++F E+ +K+ A G + ++ R+ +N+LD L+V +S+I + + + +++
Sbjct: 942 SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995
Query: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
+LR+LR LRPLR I+RA+GLK VV+ + +++ IGNIV++ +F +GVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1439 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1486
+ C + IT K + W K++FDN+ A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1487 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1546
GW +++Y +D+ D+ PI N+ + ++FI +++I+AFF++N+FVG V+ F Q
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171
Query: 1547 QEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHH 1606
Q E+E + E L+K +R + A +A+ Y ++ + V +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCV-----------EYALKARPLRRYIPKNQHQYKVWY 1214
Query: 1607 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1666
+ S Y + + +I LN + +AM+HY Q + A+ I N +FT +F +E + KL+AF
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 1667 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1726
+ +F D WN D IV+ SI+ I + EVN + + I R+ R+ R++KLL
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEENSRISITFFRLFRVMRLVKLLSRG 1332
Query: 1727 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1786
G+R LL T +++ + + LL ++LFFI+A +G+++FG + ++T + R+ F+
Sbjct: 1333 EGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQ 1389
Query: 1787 NFGMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFV 1835
F A L LFR +TG+ W IM + + C ES N+ + YF+SF
Sbjct: 1390 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFY 1449
Query: 1836 LTAQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTL 1878
+ F+++N+ +AV+M HL+E + A+ + E + ++ L++ TL
Sbjct: 1450 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 1509
Query: 1879 SPQPHSPLGSPFLWP 1893
+ PLG L P
Sbjct: 1510 LRRIQPPLGFGKLCP 1524
Score = 247 bits (631), Expect = 8e-65
Identities = 188/698 (26%), Positives = 332/698 (47%), Gaps = 98/698 (14%)
Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1324
R C I+ K F+ ++L+ IF NC+ +A+ P D +A L Y+F +F E
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173
Query: 1325 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1377
+KV+A G F AYLR+ WN+LD ++V++ + ++ + + G LG +
Sbjct: 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233
Query: 1378 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1437
+ LR R LRPLR++S L++V+ +++ ++ P+ +I ++ II+ I+G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 1438 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1476
C + D + S CA + W K+ NFDN A+
Sbjct: 294 MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353
Query: 1477 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1536
+++F + +GW D++Y DAVG D W +YF++ ++I +FFVLN+ +GV+
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404
Query: 1537 VENFHKCRQH-------QEEEEARRREEKRLRRL-------------------EKKRRNL 1570
F K R+ Q+ E ++ EE L E+K RN+
Sbjct: 405 SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464
Query: 1571 MLD---------------DVIASGSSASAA---SEAQCKPYYSDYSRF-RLLVHHLCTSH 1611
+ D+ A A S+++ Y+ ++RF R S+
Sbjct: 465 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 1612 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
+ ++ LN +T+A EHY QP L E N +F E + K+ + G + +F
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+N+ D +V I+ L E ++ ++P I ++R +R+ R+ K+ + +
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1790
L+ +++ ++ + +L LL L IF+ LG++LF G DE R +TF NF
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694
Query: 1791 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1850
+ LT+F++ TG++WN +M D + S + ++ IYF+ + ++L+NV +A+
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752
Query: 1851 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
+ +L ES A++E E E E + +T SP+ L
Sbjct: 753 VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790
Score = 148 bits (374), Expect = 5e-35
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C+ V FE I +L I NCV L ++ P + ++ L+ + F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
E +K++A G+ F YL + WN LDF IV+ G+ L+ +
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+R RVLRPLR ++ VPS+++++ ++ + L ++ LL FV I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
+ C+ E I P E+ C + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
C Q T C G P G NFDN +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
W D++Y+V DA + +IYF+ LII+GSFF++NL L V++ +FS+ +++ + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424
Query: 410 REQR 413
RE++
Sbjct: 425 REKQ 428
Score = 145 bits (367), Expect = 3e-34
Identities = 100/313 (31%), Positives = 159/313 (50%), Gaps = 22/313 (7%)
Query: 674 GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
G E + + MP S++E+V T++ D+ + + L S +WR
Sbjct: 455 GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510
Query: 732 -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
C R V S F ++ + +NTL++ E++ QP LT + +N +LF E
Sbjct: 511 RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570
Query: 790 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
MLLK+ G Y + +N FD +V + E + + G+SVLR RL+R+ K+
Sbjct: 571 MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM LFG KF + + R
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
FD+ +++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+
Sbjct: 688 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 959 LVAILVEGFQAEE 971
+AI V+ E
Sbjct: 748 FLAIAVDNLADAE 760
Score = 110 bits (276), Expect = 1e-23
Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
+ +P P + FF S ++R R C R V + F + + ILL+ ++L P +
Sbjct: 870 KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
S R IL D + F +E+++KM A G F K + + +N LD +V ++ +
Sbjct: 927 --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984
Query: 168 SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
+ ++ + R +RVLRPLRAINR ++ +V + + +GN++++ + F+F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 227 IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
+GVQL+ G L + + S + + Y T + E QPR
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089
Query: 287 TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
+W E++ F +FDN+ A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107
Query: 347 IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
+F V T EGW +++Y +D+H+ YN+ I+FI+ II+ +FFM+N+ + +
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 397 QFSETKQRE 405
F E ++E
Sbjct: 1168 TFQEQGEQE 1176
Score = 108 bits (271), Expect = 5e-23
Identities = 70/256 (27%), Positives = 132/256 (51%), Gaps = 29/256 (11%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V+S YF + + IL+NT+ + ++++ Q A+ I N++FT LF +EM+LKL+ +
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIV------GQQGGGLSV--LRTFRLMRVLKLVRFLPA 850
P Y + +N FD +IVV S+ +I ++ +S+ R FR+MR++KL+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L +K+ + +L+++ FI++++GM +FG K A D + NF +
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTEINRNNNFQTFP 1392
Query: 911 WAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFG 951
A++ +F+ T E W ++ M SS+A YFI+
Sbjct: 1393 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLC 1452
Query: 952 NYVLFNLLVAILVEGF 967
+++ NL VA++++ F
Sbjct: 1453 AFLIINLFVAVIMDNF 1468
Score = 103 bits (257), Expect = 2e-21
Identities = 92/343 (26%), Positives = 149/343 (43%), Gaps = 79/343 (23%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ I Y PE+ +NA LE +F +F +E LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178
Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
+ YG P Y++N +N+ D +IVV+ ++ + G +G G V LR
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238
Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
FR++R L+LV +P+LQ L ++K M + +L++ I I++I+G+ LF K
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298
Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
+ D P NFD+ +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358
Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKR-- 975
+T E W VLY A W +YF+ L+ G++ + NL++ +L F E +
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query: 976 -------------EDASGQLSCIQL--PVDSQGGDANKSESEP 1003
ED G L I +D + D E +P
Sbjct: 419 GDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKP 461
Score = 87.4 bits (215), Expect = 1e-16
Identities = 104/450 (23%), Positives = 194/450 (43%), Gaps = 79/450 (17%)
Query: 595 TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
TS E +EK ++A ++ P L P S + +E +S G + KI+
Sbjct: 763 TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
L+ + D PY GE + + EMP + L + H +
Sbjct: 823 MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868
Query: 712 RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
+ P+A + + +RL C +IV+ F I+ IL++++S+ E Q
Sbjct: 869 EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 769 EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
N L ++ VFTS+F LE++LK+ YG F + +N +NI D ++V +S+
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984
Query: 824 GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
G Q ++V++ R++RVL+ +R L + + + V ++T+ N+ LL F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041
Query: 878 IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
+F+ +G+ LF CK + + +DG+ + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101
Query: 910 LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
L A++ +F + T E W ++LY + S + +++FI + + + N+
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161
Query: 960 VAILVEGFQ---AEEISKREDASGQLSCIQ 986
V ++ FQ +E E Q C++
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELDKNQRQCVE 1191
Score = 65.9 bits (159), Expect = 5e-10
Identities = 47/172 (27%), Positives = 83/172 (48%), Gaps = 20/172 (11%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V + +FE + ++ILLN + L M Q C A + F F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN-------VSFSAVRTVRVLRP 187
K++A F K Y D WN D IV+ +++ ++ N +S + R RV+R
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
++ ++R +R L+ + + L V LL +FFI+ ++G+Q++ + N
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C V + F + + ++ LN +T+ E + + + + A F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
EM++KM +LG+ + Y +NR D F+V G+LE L + + S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 46.2 bits (108), Expect = 4e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
L + ++ + S E+ + + AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 328 bits (842), Expect = 3e-89
Identities = 227/804 (28%), Positives = 412/804 (51%), Gaps = 85/804 (10%)
Query: 1140 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1199
++EEE E ++ + S + + +E+ A + +++ + TA G + +
Sbjct: 767 KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823
Query: 1200 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1258
+ + ++ P+ P G++ ++E + G R R L + SA+ I
Sbjct: 824 DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query: 1259 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1318
F +RFRL CHRI+ +F +++L I L+ I++A E P + S L ++Y+FT
Sbjct: 883 FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941
Query: 1319 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1378
++F E+ +K+ A G + ++ R+ +N+LD L+V +S+I + + + +++
Sbjct: 942 SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995
Query: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
+LR+LR LRPLR I+RA+GLK VV+ + +++ IGNIV++ +F +GVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1439 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1486
+ C + IT K + W K++FDN+ A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1487 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1546
GW +++Y +D+ D+ PI N+ + ++FI +++I+AFF++N+FVG V+ F Q
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171
Query: 1547 QEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHH 1606
Q E+E + E L+K +R + A +A+ Y ++ + V +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCV-----------EYALKARPLRRYIPKNQHQYKVWY 1214
Query: 1607 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1666
+ S Y + + +I LN + +AM+HY Q + A+ I N +FT +F +E + KL+AF
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 1667 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI---------IRIMRVLRIA 1717
+ +F D WN D IV+ SI+ I + E+ +P++ I R+ R+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 1718 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCE 1777
R++KLL G+R LL T +++ + + LL ++LFFI+A +G+++FG + ++T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---T 1391
Query: 1778 GLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------I 1826
+ R+ F+ F A L LFR +TG+ W IM + + C ES N+
Sbjct: 1392 EINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1451
Query: 1827 SPIYFVSFVLTAQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAE 1870
+ YF+SF + F+++N+ +AV+M HL+E + A+ + E +
Sbjct: 1452 AVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGR 1511
Query: 1871 LE-LEMKTLSPQPHSPLGSPFLWP 1893
++ L++ TL + PLG L P
Sbjct: 1512 IKHLDVVTLLRRIQPPLGFGKLCP 1535
Score = 247 bits (631), Expect = 8e-65
Identities = 188/698 (26%), Positives = 332/698 (47%), Gaps = 98/698 (14%)
Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1324
R C I+ K F+ ++L+ IF NC+ +A+ P D +A L Y+F +F E
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173
Query: 1325 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1377
+KV+A G F AYLR+ WN+LD ++V++ + ++ + + G LG +
Sbjct: 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233
Query: 1378 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1437
+ LR R LRPLR++S L++V+ +++ ++ P+ +I ++ II+ I+G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 1438 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1476
C + D + S CA + W K+ NFDN A+
Sbjct: 294 MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353
Query: 1477 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1536
+++F + +GW D++Y DAVG D W +YF++ ++I +FFVLN+ +GV+
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404
Query: 1537 VENFHKCRQH-------QEEEEARRREEKRLRRL-------------------EKKRRNL 1570
F K R+ Q+ E ++ EE L E+K RN+
Sbjct: 405 SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464
Query: 1571 MLD---------------DVIASGSSASAA---SEAQCKPYYSDYSRF-RLLVHHLCTSH 1611
+ D+ A A S+++ Y+ ++RF R S+
Sbjct: 465 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 1612 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1671
+ ++ LN +T+A EHY QP L E N +F E + K+ + G + +F
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 1672 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
+N+ D +V I+ L E ++ ++P I ++R +R+ R+ K+ + +
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639
Query: 1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1790
L+ +++ ++ + +L LL L IF+ LG++LF G DE R +TF NF
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694
Query: 1791 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1850
+ LT+F++ TG++WN +M D + S + ++ IYF+ + ++L+NV +A+
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752
Query: 1851 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
+ +L ES A++E E E E + +T SP+ L
Sbjct: 753 VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790
Score = 148 bits (374), Expect = 5e-35
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C+ V FE I +L I NCV L ++ P + ++ L+ + F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
E +K++A G+ F YL + WN LDF IV+ G+ L+ +
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+R RVLRPLR ++ VPS+++++ ++ + L ++ LL FV I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
+ C+ E I P E+ C + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
C Q T C G P G NFDN +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
W D++Y+V DA + +IYF+ LII+GSFF++NL L V++ +FS+ +++ + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424
Query: 410 REQR 413
RE++
Sbjct: 425 REKQ 428
Score = 145 bits (367), Expect = 3e-34
Identities = 100/313 (31%), Positives = 159/313 (50%), Gaps = 22/313 (7%)
Query: 674 GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
G E + + MP S++E+V T++ D+ + + L S +WR
Sbjct: 455 GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510
Query: 732 -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
C R V S F ++ + +NTL++ E++ QP LT + +N +LF E
Sbjct: 511 RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570
Query: 790 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
MLLK+ G Y + +N FD +V + E + + G+SVLR RL+R+ K+
Sbjct: 571 MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM LFG KF + + R
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
FD+ +++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+
Sbjct: 688 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 959 LVAILVEGFQAEE 971
+AI V+ E
Sbjct: 748 FLAIAVDNLADAE 760
Score = 110 bits (276), Expect = 1e-23
Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
+ +P P + FF S ++R R C R V + F + + ILL+ ++L P +
Sbjct: 870 KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
S R IL D + F +E+++KM A G F K + + +N LD +V ++ +
Sbjct: 927 --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984
Query: 168 SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
+ ++ + R +RVLRPLRAINR ++ +V + + +GN++++ + F+F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 227 IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
+GVQL+ G L + + S + + Y T + E QPR
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089
Query: 287 TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
+W E++ F +FDN+ A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107
Query: 347 IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
+F V T EGW +++Y +D+H+ YN+ I+FI+ II+ +FFM+N+ + +
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 397 QFSETKQRE 405
F E ++E
Sbjct: 1168 TFQEQGEQE 1176
Score = 104 bits (260), Expect = 9e-22
Identities = 70/267 (26%), Positives = 132/267 (49%), Gaps = 40/267 (14%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V+S YF + + IL+NT+ + ++++ Q A+ I N++FT LF +EM+LKL+ +
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIV-----------------GQQGGGLSV--LRTFRLM 839
P Y + +N FD +IVV S+ +I ++ +S+ R FR+M
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 840 RVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT 899
R++KL+ ++ L +K+ + +L+++ FI++++GM +FG K A D
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTE 1392
Query: 900 LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWA 940
+ NF + A++ +F+ T E W ++ M SS+A
Sbjct: 1393 INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA 1452
Query: 941 ALYFIALMTFGNYVLFNLLVAILVEGF 967
YFI+ +++ NL VA++++ F
Sbjct: 1453 VFYFISFYMLCAFLIINLFVAVIMDNF 1479
Score = 103 bits (257), Expect = 2e-21
Identities = 92/343 (26%), Positives = 149/343 (43%), Gaps = 79/343 (23%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ I Y PE+ +NA LE +F +F +E LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178
Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
+ YG P Y++N +N+ D +IVV+ ++ + G +G G V LR
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238
Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
FR++R L+LV +P+LQ L ++K M + +L++ I I++I+G+ LF K
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298
Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
+ D P NFD+ +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358
Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKR-- 975
+T E W VLY A W +YF+ L+ G++ + NL++ +L F E +
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query: 976 -------------EDASGQLSCIQL--PVDSQGGDANKSESEP 1003
ED G L I +D + D E +P
Sbjct: 419 GDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKP 461
Score = 87.4 bits (215), Expect = 1e-16
Identities = 104/450 (23%), Positives = 194/450 (43%), Gaps = 79/450 (17%)
Query: 595 TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
TS E +EK ++A ++ P L P S + +E +S G + KI+
Sbjct: 763 TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
L+ + D PY GE + + EMP + L + H +
Sbjct: 823 MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868
Query: 712 RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
+ P+A + + +RL C +IV+ F I+ IL++++S+ E Q
Sbjct: 869 EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 769 EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
N L ++ VFTS+F LE++LK+ YG F + +N +NI D ++V +S+
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984
Query: 824 GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
G Q ++V++ R++RVL+ +R L + + + V ++T+ N+ LL F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041
Query: 878 IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
+F+ +G+ LF CK + + +DG+ + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101
Query: 910 LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
L A++ +F + T E W ++LY + S + +++FI + + + N+
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161
Query: 960 VAILVEGFQ---AEEISKREDASGQLSCIQ 986
V ++ FQ +E E Q C++
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELDKNQRQCVE 1191
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C V + F + + ++ LN +T+ E + + + + A F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
EM++KM +LG+ + Y +NR D F+V G+LE L + + S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 61.6 bits (148), Expect = 9e-09
Identities = 47/183 (25%), Positives = 83/183 (45%), Gaps = 31/183 (16%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V + +FE + ++ILLN + L M Q C A + F F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN------------------VSF 176
K++A F K Y D WN D IV+ +++ ++ N +S
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISI 1325
Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ R RV+R ++ ++R +R L+ + + L V LL +FFI+ ++G+Q++ +
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385
Query: 237 LRN 239
N
Sbjct: 1386 ALN 1388
Score = 46.2 bits (108), Expect = 4e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
L + ++ + S E+ + + AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,352,461
Number of Sequences: 37866
Number of extensions: 5614248
Number of successful extensions: 43010
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 253
Number of HSP's successfully gapped in prelim test: 664
Number of HSP's that attempted gapping in prelim test: 31088
Number of HSP's gapped (non-prelim): 7552
length of query: 2332
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2213
effective length of database: 13,741,464
effective search space: 30409859832
effective search space used: 30409859832
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.