Guide to the Human Genome
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Search of human proteins with 38505280

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
         (2306 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38505280 voltage-dependent calcium channel alpha 1G subunit i...  4661   0.0  
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i...  4638   0.0  
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i...  4625   0.0  
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...  4600   0.0  
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i...  4556   0.0  
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i...  4551   0.0  
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i...  4543   0.0  
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...  4525   0.0  
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...  4517   0.0  
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...  4512   0.0  
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...  4512   0.0  
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...  4504   0.0  
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...  4499   0.0  
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...  4065   0.0  
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...  2319   0.0  
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...  2315   0.0  
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...  1474   0.0  
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...  1474   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...   444   e-124
gi|150417967 voltage-gated sodium channel type V alpha isoform c...   444   e-124
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...   442   e-123
gi|237512982 voltage-gated sodium channel type V alpha isoform f...   430   e-120
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...   419   e-116
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...   345   4e-94
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...   330   8e-90
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1...   329   2e-89
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1...   329   2e-89
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1...   328   3e-89
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1...   328   3e-89

>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
            isoform 6 [Homo sapiens]
          Length = 2306

 Score = 4661 bits (12090), Expect = 0.0
 Identities = 2306/2306 (100%), Positives = 2306/2306 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
            AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV
Sbjct: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920

Query: 1921 SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1980
            SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS
Sbjct: 1921 SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1980

Query: 1981 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2040
            YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW
Sbjct: 1981 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2040

Query: 2041 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2100
            GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG
Sbjct: 2041 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2100

Query: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2160
            QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP
Sbjct: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2160

Query: 2161 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2220
            GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG
Sbjct: 2161 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2220

Query: 2221 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2280
            GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS
Sbjct: 2221 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2280

Query: 2281 MAASPSPKKDVLSLSGLSSDPADLDP 2306
            MAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2281 MAASPSPKKDVLSLSGLSSDPADLDP 2306


>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
            isoform 2 [Homo sapiens]
          Length = 2354

 Score = 4638 bits (12031), Expect = 0.0
 Identities = 2306/2354 (97%), Positives = 2306/2354 (97%), Gaps = 48/2354 (2%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
            AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---------------- 1904
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT                
Sbjct: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSL 1920

Query: 1905 --------------------------------IPLAEMEALSLTSEIVSEPSCSLALTDD 1932
                                            IPLAEMEALSLTSEIVSEPSCSLALTDD
Sbjct: 1921 EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAEMEALSLTSEIVSEPSCSLALTDD 1980

Query: 1933 SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP 1992
            SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP
Sbjct: 1981 SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP 2040

Query: 1993 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRS 2052
            LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRS
Sbjct: 2041 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRS 2100

Query: 2053 PLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRS 2112
            PLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRS
Sbjct: 2101 PLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRS 2160

Query: 2113 HSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL 2172
            HSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL
Sbjct: 2161 HSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL 2220

Query: 2173 KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPK 2232
            KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPK
Sbjct: 2221 KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPK 2280

Query: 2233 KKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVL 2292
            KKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVL
Sbjct: 2281 KKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVL 2340

Query: 2293 SLSGLSSDPADLDP 2306
            SLSGLSSDPADLDP
Sbjct: 2341 SLSGLSSDPADLDP 2354


>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
            isoform 1 [Homo sapiens]
          Length = 2377

 Score = 4625 bits (11997), Expect = 0.0
 Identities = 2306/2377 (97%), Positives = 2306/2377 (97%), Gaps = 71/2377 (2%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
            VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
            RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
            AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800

Query: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
            GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860

Query: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
            AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920

Query: 1898 FSLEHPT------------------------------------------------IPLAE 1909
            FSLEHPT                                                IPLAE
Sbjct: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAE 1980

Query: 1910 MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG 1969
            MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG
Sbjct: 1981 MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG 2040

Query: 1970 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2029
            VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP
Sbjct: 2041 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2100

Query: 2030 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2089
            HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS
Sbjct: 2101 HLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPS 2160

Query: 2090 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2149
            PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE
Sbjct: 2161 PPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTE 2220

Query: 2150 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2209
            LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ
Sbjct: 2221 LSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ 2280

Query: 2210 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2269
            PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS
Sbjct: 2281 PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDS 2340

Query: 2270 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2341 KDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2377


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score = 4600 bits (11930), Expect = 0.0
 Identities = 2289/2354 (97%), Positives = 2290/2354 (97%), Gaps = 59/2354 (2%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR           S   
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-----------SKEK 1549

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
              +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1550 QMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1609

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1669

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1670 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1729

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1730 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1849

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---------------- 1904
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT                
Sbjct: 1850 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSL 1909

Query: 1905 --------------------------------IPLAEMEALSLTSEIVSEPSCSLALTDD 1932
                                            IPLAEMEALSLTSEIVSEPSCSLALTDD
Sbjct: 1910 EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAEMEALSLTSEIVSEPSCSLALTDD 1969

Query: 1933 SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP 1992
            SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP
Sbjct: 1970 SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP 2029

Query: 1993 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRS 2052
            LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRS
Sbjct: 2030 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRS 2089

Query: 2053 PLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRS 2112
            PLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRS
Sbjct: 2090 PLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRS 2149

Query: 2113 HSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL 2172
            HSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL
Sbjct: 2150 HSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL 2209

Query: 2173 KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPK 2232
            KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPK
Sbjct: 2210 KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPK 2269

Query: 2233 KKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVL 2292
            KKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVL
Sbjct: 2270 KKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVL 2329

Query: 2293 SLSGLSSDPADLDP 2306
            SLSGLSSDPADLDP
Sbjct: 2330 SLSGLSSDPADLDP 2343


>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
            isoform 11 [Homo sapiens]
          Length = 2261

 Score = 4556 bits (11816), Expect = 0.0
 Identities = 2261/2306 (98%), Positives = 2261/2306 (98%), Gaps = 45/2306 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
            AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT                
Sbjct: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---------------- 1904

Query: 1921 SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1980
                                         MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS
Sbjct: 1905 -----------------------------MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1935

Query: 1981 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2040
            YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW
Sbjct: 1936 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 1995

Query: 2041 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2100
            GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG
Sbjct: 1996 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2055

Query: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2160
            QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP
Sbjct: 2056 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2115

Query: 2161 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2220
            GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG
Sbjct: 2116 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2175

Query: 2221 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2280
            GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS
Sbjct: 2176 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2235

Query: 2281 MAASPSPKKDVLSLSGLSSDPADLDP 2306
            MAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2236 MAASPSPKKDVLSLSGLSSDPADLDP 2261


>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
            isoform 4 [Homo sapiens]
          Length = 2332

 Score = 4551 bits (11804), Expect = 0.0
 Identities = 2270/2335 (97%), Positives = 2276/2335 (97%), Gaps = 32/2335 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
            VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
            RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
            AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800

Query: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
            GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860

Query: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
            AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920

Query: 1898 FSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDD-SLPDDMHTLLLSA-----LESNMQ 1951
            FSLEHPT      + +SL   I       L L D+ + P    +   SA      +  MQ
Sbjct: 1921 FSLEHPT-DRQLFDTISLL--IQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQ 1977

Query: 1952 PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV 2011
            PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV
Sbjct: 1978 PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV 2037

Query: 2012 HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD 2071
            HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD
Sbjct: 2038 HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD 2097

Query: 2072 VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP 2131
            VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP
Sbjct: 2098 VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP 2157

Query: 2132 NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL 2191
            NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL
Sbjct: 2158 NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL 2217

Query: 2192 DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR 2251
            DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR
Sbjct: 2218 DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR 2277

Query: 2252 TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2278 TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332


>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
            isoform 8 [Homo sapiens]
          Length = 2284

 Score = 4543 bits (11782), Expect = 0.0
 Identities = 2261/2329 (97%), Positives = 2261/2329 (97%), Gaps = 68/2329 (2%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
            VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
            RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
            AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800

Query: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
            GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860

Query: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
            AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920

Query: 1898 FSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTEL 1957
            FSLEHPT                                             MQPHPTEL
Sbjct: 1921 FSLEHPT---------------------------------------------MQPHPTEL 1935

Query: 1958 PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD 2017
            PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD
Sbjct: 1936 PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD 1995

Query: 2018 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2077
            TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS
Sbjct: 1996 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2055

Query: 2078 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2137
            REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP
Sbjct: 2056 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2115

Query: 2138 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2197
            PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH
Sbjct: 2116 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2175

Query: 2198 SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG 2257
            SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG
Sbjct: 2176 SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG 2235

Query: 2258 ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2236 ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2284


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score = 4525 bits (11737), Expect = 0.0
 Identities = 2253/2312 (97%), Positives = 2260/2312 (97%), Gaps = 20/2312 (0%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR           S   
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-----------SKEK 1549

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
              +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1550 QMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1609

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1669

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1670 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1729

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1730 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1849

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT      + +SL   I 
Sbjct: 1850 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT-DRQLFDTISLL--IQ 1906

Query: 1921 SEPSCSLALTDD-SLPDDMHTLLLSA-----LESNMQPHPTELPGPDLLTVRKSGVSRTH 1974
                  L L D+ + P    +   SA      +  MQPHPTELPGPDLLTVRKSGVSRTH
Sbjct: 1907 GSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTVRKSGVSRTH 1966

Query: 1975 SLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQP 2034
            SLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQP
Sbjct: 1967 SLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQP 2026

Query: 2035 HSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLAR 2094
            HSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLAR
Sbjct: 2027 HSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLAR 2086

Query: 2095 AYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWIS 2154
            AYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWIS
Sbjct: 2087 AYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWIS 2146

Query: 2155 GDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGT 2214
            GDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGT
Sbjct: 2147 GDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGT 2206

Query: 2215 DPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLA 2274
            DPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLA
Sbjct: 2207 DPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLA 2266

Query: 2275 SGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            SGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2267 SGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2298


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score = 4517 bits (11715), Expect = 0.0
 Identities = 2244/2306 (97%), Positives = 2245/2306 (97%), Gaps = 56/2306 (2%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR           S   
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-----------SKEK 1549

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
              +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1550 QMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1609

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1669

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1670 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1729

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1730 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1849

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT                
Sbjct: 1850 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---------------- 1893

Query: 1921 SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1980
                                         MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS
Sbjct: 1894 -----------------------------MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1924

Query: 1981 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2040
            YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW
Sbjct: 1925 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 1984

Query: 2041 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2100
            GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG
Sbjct: 1985 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2044

Query: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2160
            QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP
Sbjct: 2045 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2104

Query: 2161 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2220
            GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG
Sbjct: 2105 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2164

Query: 2221 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2280
            GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS
Sbjct: 2165 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2224

Query: 2281 MAASPSPKKDVLSLSGLSSDPADLDP 2306
            MAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2225 MAASPSPKKDVLSLSGLSSDPADLDP 2250


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score = 4512 bits (11703), Expect = 0.0
 Identities = 2253/2335 (96%), Positives = 2260/2335 (96%), Gaps = 43/2335 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
            VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
            RRLEKKRR           S     +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1609

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1610 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
            AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789

Query: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
            GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1790 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1849

Query: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
            AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1850 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1909

Query: 1898 FSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDD-SLPDDMHTLLLSA-----LESNMQ 1951
            FSLEHPT      + +SL   I       L L D+ + P    +   SA      +  MQ
Sbjct: 1910 FSLEHPT-DRQLFDTISLL--IQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQ 1966

Query: 1952 PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV 2011
            PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV
Sbjct: 1967 PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSV 2026

Query: 2012 HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD 2071
            HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD
Sbjct: 2027 HSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLD 2086

Query: 2072 VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP 2131
            VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP
Sbjct: 2087 VQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP 2146

Query: 2132 NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL 2191
            NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL
Sbjct: 2147 NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWL 2206

Query: 2192 DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR 2251
            DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR
Sbjct: 2207 DEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR 2266

Query: 2252 TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2267 TPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2321


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score = 4512 bits (11702), Expect = 0.0
 Identities = 2242/2306 (97%), Positives = 2243/2306 (97%), Gaps = 63/2306 (2%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR               
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR--------------- 1545

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
               +AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1546 ---KAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1602

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1603 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1662

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1663 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1722

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1723 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1782

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1783 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1842

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT                
Sbjct: 1843 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---------------- 1886

Query: 1921 SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1980
                                         MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS
Sbjct: 1887 -----------------------------MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1917

Query: 1981 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2040
            YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW
Sbjct: 1918 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 1977

Query: 2041 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2100
            GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG
Sbjct: 1978 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG 2037

Query: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2160
            QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP
Sbjct: 2038 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP 2097

Query: 2161 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2220
            GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG
Sbjct: 2098 GGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2157

Query: 2221 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2280
            GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS
Sbjct: 2158 GQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDS 2217

Query: 2281 MAASPSPKKDVLSLSGLSSDPADLDP 2306
            MAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2218 MAASPSPKKDVLSLSGLSSDPADLDP 2243


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score = 4504 bits (11681), Expect = 0.0
 Identities = 2244/2329 (96%), Positives = 2245/2329 (96%), Gaps = 79/2329 (3%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
            VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
            RRLEKKRR           S     +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1609

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1610 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
            AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789

Query: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
            GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1790 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1849

Query: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
            AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1850 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1909

Query: 1898 FSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTEL 1957
            FSLEHPT                                             MQPHPTEL
Sbjct: 1910 FSLEHPT---------------------------------------------MQPHPTEL 1924

Query: 1958 PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD 2017
            PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD
Sbjct: 1925 PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD 1984

Query: 2018 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2077
            TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS
Sbjct: 1985 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2044

Query: 2078 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2137
            REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP
Sbjct: 2045 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2104

Query: 2138 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2197
            PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH
Sbjct: 2105 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2164

Query: 2198 SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG 2257
            SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG
Sbjct: 2165 SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG 2224

Query: 2258 ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2225 ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2273


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score = 4499 bits (11668), Expect = 0.0
 Identities = 2242/2329 (96%), Positives = 2243/2329 (96%), Gaps = 86/2329 (3%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
            VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
            RRLEKKRR                  +AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRR------------------KAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1602

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1603 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1662

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
            AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1663 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1722

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1723 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1782

Query: 1778 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1837
            GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1783 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1842

Query: 1838 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1897
            AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1843 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1902

Query: 1898 FSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTEL 1957
            FSLEHPT                                             MQPHPTEL
Sbjct: 1903 FSLEHPT---------------------------------------------MQPHPTEL 1917

Query: 1958 PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD 2017
            PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD
Sbjct: 1918 PGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD 1977

Query: 2018 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2077
            TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS
Sbjct: 1978 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2037

Query: 2078 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2137
            REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP
Sbjct: 2038 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2097

Query: 2138 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2197
            PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH
Sbjct: 2098 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2157

Query: 2198 SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG 2257
            SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG
Sbjct: 2158 SIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPG 2217

Query: 2258 ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2218 ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2266


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score = 4065 bits (10542), Expect = 0.0
 Identities = 2050/2177 (94%), Positives = 2058/2177 (94%), Gaps = 64/2177 (2%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
            AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
            AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080

Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
            TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140

Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
            LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200

Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
            ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
            VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320

Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
            SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380

Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
            TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440

Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
            RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500

Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
            VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR           S   
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-----------SKEK 1549

Query: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
              +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1550 QMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1609

Query: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
            KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1669

Query: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
            NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1670 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1729

Query: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
            LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1730 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
            TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1849

Query: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920
            SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT                
Sbjct: 1850 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---------------- 1893

Query: 1921 SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1980
                                         MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS
Sbjct: 1894 -----------------------------MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1924

Query: 1981 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2040
            YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW
Sbjct: 1925 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 1984

Query: 2041 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSP-PLARAYSFW 2099
            GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE   PSP  L + YS  
Sbjct: 1985 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKCYSVE 2044

Query: 2100 GQS----STQAQQHSRSHS-KISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWIS 2154
             QS     T      R HS  +S   +   P  G +P+   G P          +LS  S
Sbjct: 2045 AQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS 2104

Query: 2155 GDLLPP--GGQEEPPSP 2169
              + PP   G   PPSP
Sbjct: 2105 ITIDPPESQGPRTPPSP 2121



 Score =  305 bits (781), Expect = 3e-82
 Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)

Query: 2059 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2118
            +R+    RT SL       R    AE  GP       +  WG    Q+      HS+ + 
Sbjct: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961

Query: 2119 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2153
                  +   AP    P   P WG   K PP  RS L               LD +    
Sbjct: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021

Query: 2154 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2213
              DLL    +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078

Query: 2214 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2273
            TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138

Query: 2274 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
            ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171


>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
            isoform 15 [Homo sapiens]
          Length = 1555

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  108 bits (269), Expect = 8e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786

Query: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834

Query: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894

Query: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936

Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977



 Score =  107 bits (266), Expect = 2e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 1587 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1646
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801

Query: 1647 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1706
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851

Query: 1707 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1766
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910

Query: 1767 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1826
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962

Query: 1827 LMKHLEESNKEAKEEA 1842
            L++  +      +E+A
Sbjct: 963  LVEGFQAEEISKREDA 978



 Score =  103 bits (256), Expect = 3e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1575 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1632
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1633 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1688
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380

Query: 1689 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434



 Score = 68.2 bits (165), Expect = 9e-11
 Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)

Query: 1525 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1570
            EEE+    EE       + R  + L+D+  +G             SA SEA+  PY    
Sbjct: 3    EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57

Query: 1571 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1620
                   S  SR R        + + +     VI LN VT+ M    +    D      L
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117

Query: 1621 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1677
            +  +      F +E V K+VA   FG + +  D WN+LD  IV+  ++  +L+   V+ S
Sbjct: 118  QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177

Query: 1678 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1737
                      +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFIF  +
Sbjct: 178  A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228

Query: 1738 GVELFGDL 1745
            GV+L+  L
Sbjct: 229  GVQLWAGL 236



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370

Query: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score = 2319 bits (6009), Expect = 0.0
 Identities = 1338/2390 (55%), Positives = 1562/2390 (65%), Gaps = 235/2390 (9%)

Query: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85

Query: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145

Query: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205

Query: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265

Query: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322

Query: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382

Query: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442

Query: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500

Query: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555

Query: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615

Query: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670

Query: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730

Query: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790

Query: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850

Query: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910

Query: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970

Query: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030

Query: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090

Query: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148

Query: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208

Query: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251

Query: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311

Query: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371

Query: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431

Query: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491

Query: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551

Query: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPY 1570
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RR            S   + EAQ +PY
Sbjct: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR------------STFPSPEAQRRPY 1599

Query: 1571 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1630
            Y+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++
Sbjct: 1600 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1659

Query: 1631 FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV 1690
            FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRV
Sbjct: 1660 FVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719

Query: 1691 LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDET 1750
            LRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E 
Sbjct: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSED 1779

Query: 1751 HPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIY 1807
            +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+Y
Sbjct: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839

Query: 1808 FVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPF 1867
            FV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM               
Sbjct: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--------------- 1884

Query: 1868 LWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIVSEPSCSL 1927
                 +GP                  SA     + P +P     A    + +  + S S 
Sbjct: 1885 ----AQGPG-----------------SARRVDADRPPLPQESPGARDAPNLVARKVSVSR 1923

Query: 1928 ALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGS 1987
             L   SLP+D +  +   +     PHP  L   ++ T                       
Sbjct: 1924 ML---SLPNDSY--MFRPVVPASAPHPRPLQEVEMETY---------------------- 1956

Query: 1988 TAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLP 2047
                     G G P    GSV SVHS PA++   LQ+P     L     A +   +  L 
Sbjct: 1957 ---------GAGTP---LGSVASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALS 1999

Query: 2048 PPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG-- 2100
            P G  RSP   R L RQ A+ TDSL+ +    R+ L     G   P  P+ +  S     
Sbjct: 2000 PRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPP 2059

Query: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP- 2159
            +S   A   +R H+   + ++     PG E        E  +S   D E+S I+    P 
Sbjct: 2060 RSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------EAEASDPADEEVSHITSSACPW 2111

Query: 2160 -----PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPH 2211
                 P G E  P     RDL++ YSV+AQ    +P    DEQ R S  +   + G    
Sbjct: 2112 QPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKP-GRADEQWRPSAELGSGEPGEAKA 2170

Query: 2212 LGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS- 2266
             G +      +P    G+R KKK+SPP I+++PP E +G   P +       LRRR PS 
Sbjct: 2171 WGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSC 2223

Query: 2267 -----SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGLSSDPADL 2304
                  DS +P     A G P +        S + + L++   + +P DL
Sbjct: 2224 EATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDL 2273


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score = 2315 bits (5998), Expect = 0.0
 Identities = 1336/2390 (55%), Positives = 1560/2390 (65%), Gaps = 241/2390 (10%)

Query: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85

Query: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145

Query: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205

Query: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265

Query: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322

Query: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382

Query: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442

Query: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500

Query: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555

Query: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615

Query: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670

Query: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730

Query: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790

Query: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850

Query: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910

Query: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970

Query: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030

Query: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090

Query: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148

Query: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208

Query: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251

Query: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311

Query: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371

Query: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431

Query: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491

Query: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551

Query: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPY 1570
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RR                  +AQ +PY
Sbjct: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR------------------KAQRRPY 1593

Query: 1571 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1630
            Y+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++
Sbjct: 1594 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1653

Query: 1631 FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV 1690
            FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRV
Sbjct: 1654 FVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1713

Query: 1691 LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDET 1750
            LRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E 
Sbjct: 1714 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSED 1773

Query: 1751 HPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIY 1807
            +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+Y
Sbjct: 1774 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1833

Query: 1808 FVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPF 1867
            FV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM               
Sbjct: 1834 FVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--------------- 1878

Query: 1868 LWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIVSEPSCSL 1927
                 +GP                  SA     + P +P     A    + +  + S S 
Sbjct: 1879 ----AQGPG-----------------SARRVDADRPPLPQESPGARDAPNLVARKVSVSR 1917

Query: 1928 ALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGS 1987
             L   SLP+D +  +   +     PHP  L   ++ T                       
Sbjct: 1918 ML---SLPNDSY--MFRPVVPASAPHPRPLQEVEMETY---------------------- 1950

Query: 1988 TAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLP 2047
                     G G P    GSV SVHS PA++   LQ+P     L     A +   +  L 
Sbjct: 1951 ---------GAGTP---LGSVASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALS 1993

Query: 2048 PPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG-- 2100
            P G  RSP   R L RQ A+ TDSL+ +    R+ L     G   P  P+ +  S     
Sbjct: 1994 PRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPP 2053

Query: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP- 2159
            +S   A   +R H+   + ++     PG E        E  +S   D E+S I+    P 
Sbjct: 2054 RSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------EAEASDPADEEVSHITSSACPW 2105

Query: 2160 -----PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPH 2211
                 P G E  P     RDL++ YSV+AQ    +P    DEQ R S  +   + G    
Sbjct: 2106 QPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKP-GRADEQWRPSAELGSGEPGEAKA 2164

Query: 2212 LGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS- 2266
             G +      +P    G+R KKK+SPP I+++PP E +G   P +       LRRR PS 
Sbjct: 2165 WGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSC 2217

Query: 2267 -----SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGLSSDPADL 2304
                  DS +P     A G P +        S + + L++   + +P DL
Sbjct: 2218 EATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDL 2267


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score = 1474 bits (3815), Expect = 0.0
 Identities = 911/1756 (51%), Positives = 1080/1756 (61%), Gaps = 253/1756 (14%)

Query: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568

Query: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628

Query: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688

Query: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748

Query: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808

Query: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868

Query: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911

Query: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965

Query: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025

Query: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084

Query: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144

Query: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204

Query: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264

Query: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324

Query: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384

Query: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR                 
Sbjct: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1427

Query: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622
             +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK 
Sbjct: 1428 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1486

Query: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682
            CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1487 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1546

Query: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
            TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1547 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1606

Query: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801
            G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C ++
Sbjct: 1607 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1666

Query: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858
            +  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P 
Sbjct: 1667 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1726

Query: 1859 PHSPLGSPFLWPGVEGPD-----------------SP----------------------- 1878
            P  P GSP   PG  GP                  SP                       
Sbjct: 1727 PRLPTGSPGA-PG-RGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELT 1784

Query: 1879 --DSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDD-SLP 1935
              D+      H  +          +   + LAE EA SL     S+ S S+ L DD SL 
Sbjct: 1785 IIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSILLGDDLSLE 1840

Query: 1936 DDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTA 1989
            D       +A     +    EL  P+ + V   G     +S T   P+ ++++C      
Sbjct: 1841 DP------TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIP 1894

Query: 1990 EGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTI 2043
              P+  R W   K  S         P  +S +L +P +  H         P      GT+
Sbjct: 1895 FNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTL 1950

Query: 2044 PKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSF 2098
            PK+   G     RSP     L RQA     SLD              + PS       + 
Sbjct: 1951 PKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTT 1996

Query: 2099 WGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLL 2158
               S T +    R+       + PPAP PGP        P  R  L L            
Sbjct: 1997 LEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL------------ 2034

Query: 2159 PPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN 2218
                       R L     + A             QR HS   S    G   H   DPS+
Sbjct: 2035 ---------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSD 2072

Query: 2219 ---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----K 2270
                GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S     
Sbjct: 2073 EEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPG 2128

Query: 2271 DPLASGPPDSMAASPS 2286
             P A+     +A SPS
Sbjct: 2129 RPHAAALAHGLARSPS 2144



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84

Query: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144

Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204

Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264

Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321

Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381

Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440

Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172

Query: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232

Query: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292

Query: 233  WAG 235
            + G
Sbjct: 1293 FKG 1295



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130

Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182

Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145

Query: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196

Query: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591

Query: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647

Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703

Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612



 Score = 62.0 bits (149), Expect = 7e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130

Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190

Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388

Query: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431

Query: 1565 AQC 1567
              C
Sbjct: 432  GDC 434



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398

Query: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458

Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508

Query: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568

Query: 1130 PAGSD 1134
              G +
Sbjct: 569  ELGKE 573



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827

Query: 396 TQF 398
             F
Sbjct: 828 EGF 830



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707



 Score = 37.0 bits (84), Expect = 0.22
 Identities = 42/195 (21%), Positives = 72/195 (36%), Gaps = 44/195 (22%)

Query: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391

Query: 1822 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1866
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446

Query: 1867 --------FLWPGVE------GPDSPDSPKPG--ALHPAAHARSASHFSLEHPTIPLAEM 1910
                     L+  ++      GP++P   KPG  A  P  +     H  L+     L + 
Sbjct: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQP 506

Query: 1911 EALSLTSEIVSEPSC 1925
               +L S+  S P C
Sbjct: 507  IPATLASDPASCPCC 521


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score = 1474 bits (3815), Expect = 0.0
 Identities = 911/1756 (51%), Positives = 1080/1756 (61%), Gaps = 253/1756 (14%)

Query: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 547  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603

Query: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 604  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663

Query: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 664  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723

Query: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 724  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783

Query: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 784  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843

Query: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 844  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903

Query: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 904  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946

Query: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 947  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000

Query: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060

Query: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119

Query: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179

Query: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239

Query: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299

Query: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359

Query: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419

Query: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR                 
Sbjct: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1462

Query: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622
             +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK 
Sbjct: 1463 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1521

Query: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682
            CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1522 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1581

Query: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
            TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1582 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1641

Query: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801
            G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C ++
Sbjct: 1642 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1701

Query: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858
            +  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P 
Sbjct: 1702 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1761

Query: 1859 PHSPLGSPFLWPGVEGPD-----------------SP----------------------- 1878
            P  P GSP   PG  GP                  SP                       
Sbjct: 1762 PRLPTGSPGA-PG-RGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELT 1819

Query: 1879 --DSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDD-SLP 1935
              D+      H  +          +   + LAE EA SL     S+ S S+ L DD SL 
Sbjct: 1820 IIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSILLGDDLSLE 1875

Query: 1936 DDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTA 1989
            D       +A     +    EL  P+ + V   G     +S T   P+ ++++C      
Sbjct: 1876 DP------TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIP 1929

Query: 1990 EGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTI 2043
              P+  R W   K  S         P  +S +L +P +  H         P      GT+
Sbjct: 1930 FNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTL 1985

Query: 2044 PKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSF 2098
            PK+   G     RSP     L RQA     SLD              + PS       + 
Sbjct: 1986 PKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTT 2031

Query: 2099 WGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLL 2158
               S T +    R+       + PPAP PGP        P  R  L L            
Sbjct: 2032 LEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL------------ 2069

Query: 2159 PPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN 2218
                       R L     + A             QR HS   S    G   H   DPS+
Sbjct: 2070 ---------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSD 2107

Query: 2219 ---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----K 2270
                GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S     
Sbjct: 2108 EEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPG 2163

Query: 2271 DPLASGPPDSMAASPS 2286
             P A+     +A SPS
Sbjct: 2164 RPHAAALAHGLARSPS 2179



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84

Query: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144

Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204

Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264

Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321

Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381

Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440

Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472



 Score =  134 bits (337), Expect = 1e-30
 Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398

Query: 965  EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
              F        SE++             R+  L L       E R+  L    + + A P
Sbjct: 399  TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431

Query: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
                +     +   L  A RR      A       +  ++P  A+  PH+          
Sbjct: 432  GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481

Query: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
             +  R+  G+                  G+G E +       +    PA   + H G   
Sbjct: 482  -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524

Query: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
                S  D  P TL  P     AS   S    +H+D           +G+  SG  + A 
Sbjct: 525  CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584

Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
              D+   DG  + ++G  S+  +          A  L  D W       ++R +L    I
Sbjct: 585  GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636

Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
            +  K F+  +++ I +N +++ +E  +  P     I L + N +FT++F  EM +K+ A 
Sbjct: 637  VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693

Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
               FG   YLR+ +N+ D ++V+IS+ +I+    +D G  +L   R+LR+L+ +R +  +
Sbjct: 694  ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748

Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
             R    +LVV  LM ++  +    ++   F  IF ILG+ +F  KF +           +
Sbjct: 749  RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791

Query: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
            +D  +     V  + NFD+L  A++++F + +++ W  ++Y+G+ +           +PW
Sbjct: 792  TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837

Query: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
              LYF++ +    + + N+ V ++VE F      Q E +A R
Sbjct: 838  ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207

Query: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267

Query: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327

Query: 233  WAG 235
            + G
Sbjct: 1328 FKG 1330



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130

Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182

Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145

Query: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196

Query: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626

Query: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682

Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738

Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647



 Score = 62.0 bits (149), Expect = 7e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130

Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190

Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388

Query: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431

Query: 1565 AQC 1567
              C
Sbjct: 432  GDC 434



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862

Query: 396 TQF 398
             F
Sbjct: 863 EGF 865



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)

Query: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391

Query: 1822 VVIAVLMKHLEESNK 1836
            + + V+     E+ +
Sbjct: 392  LCLVVIATQFSETKQ 406


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score =  444 bits (1141), Expect = e-124
 Identities = 330/1155 (28%), Positives = 562/1155 (48%), Gaps = 116/1155 (10%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
            F A+   A   + E +    +L     G    K+     C  L  L + P+   +L    
Sbjct: 942  FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999

Query: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
             LP  I    ATP S P   +    E + P  + T      +PG     +  P       
Sbjct: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046

Query: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
             P + A S T        NSLG                  S + QESQ      E    S
Sbjct: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092

Query: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
               S      S E EA +S    D  Q       A G G   E     G +A       L
Sbjct: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150

Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
                P L  D  D E   ++G         R P C ++       ++    R R  C+ I
Sbjct: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201

Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
            + H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA 
Sbjct: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261

Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
            G+    + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +
Sbjct: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314

Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
            SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N
Sbjct: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374

Query: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
             T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G 
Sbjct: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434

Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLR 1538
            ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE    
Sbjct: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE---- 1490

Query: 1539 RLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1598
              +KK  N M              S+   KP     ++++  +  + T    D+ I  +I
Sbjct: 1491 --QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLI 1538

Query: 1599 GLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
             LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D 
Sbjct: 1539 CLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
             +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +L
Sbjct: 1597 VVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            P + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T
Sbjct: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709

Query: 1778 GDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1825
               W+G++   L      CD            C +  +  ++F ++++ +  ++VN+ IA
Sbjct: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769

Query: 1826 VLMKHLEESNKEAKE 1840
            +++++   + +E+ E
Sbjct: 1770 IILENFSVATEESTE 1784



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521



 Score =  132 bits (332), Expect = 4e-30
 Identities = 195/900 (21%), Positives = 352/900 (39%), Gaps = 203/900 (22%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237

Query: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471

Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508

Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568

Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621

Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681

Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741

Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795

Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847

Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892

Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  118 bits (296), Expect = 6e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)

Query: 1543 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1588
            ++R L    V+ S       S  +C P ++  ++ R L+   C                 
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1768
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1769 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939

Query: 1829 KHLEESNKEAKEEAELEAELELEM 1852
                  N  A +E      L+L +
Sbjct: 940  SSFSADNLTAPDEDREMNNLQLAL 963



 Score =  103 bits (257), Expect = 2e-21
 Identities = 89/370 (24%), Positives = 156/370 (42%), Gaps = 79/370 (21%)

Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214

Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274

Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
                     F    G                                D     N SD   
Sbjct: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334

Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383

Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443

Query: 1543 KRRNLMLDDV 1552
            +   L +  V
Sbjct: 444  EHEALTIRGV 453



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398

Query: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458

Query: 953  YVLFNLLVAILVEGFQAE 970
            +   NL + ++++ F  +
Sbjct: 1459 FFTLNLFIGVIIDNFNQQ 1476



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698

Query: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758

Query: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174

Query: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229

Query: 1694 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1738
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289

Query: 1739 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1758
                VE  G      DL                            C E + C   G    
Sbjct: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349

Query: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401

Query: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score =  444 bits (1141), Expect = e-124
 Identities = 330/1155 (28%), Positives = 562/1155 (48%), Gaps = 116/1155 (10%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
            F A+   A   + E +    +L     G    K+     C  L  L + P+   +L    
Sbjct: 942  FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999

Query: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
             LP  I    ATP S P   +    E + P  + T      +PG     +  P       
Sbjct: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046

Query: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
             P + A S T        NSLG                  S + QESQ      E    S
Sbjct: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092

Query: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
               S      S E EA +S    D  Q       A G G   E     G +A       L
Sbjct: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150

Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
                P L  D  D E   ++G         R P C ++       ++    R R  C+ I
Sbjct: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201

Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
            + H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA 
Sbjct: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261

Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
            G+    + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +
Sbjct: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314

Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
            SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N
Sbjct: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374

Query: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
             T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G 
Sbjct: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434

Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLR 1538
            ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE    
Sbjct: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE---- 1490

Query: 1539 RLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1598
              +KK  N M              S+   KP     ++++  +  + T    D+ I  +I
Sbjct: 1491 --QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLI 1538

Query: 1599 GLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
             LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D 
Sbjct: 1539 CLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
             +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +L
Sbjct: 1597 VVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            P + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T
Sbjct: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709

Query: 1778 GDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1825
               W+G++   L      CD            C +  +  ++F ++++ +  ++VN+ IA
Sbjct: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769

Query: 1826 VLMKHLEESNKEAKE 1840
            +++++   + +E+ E
Sbjct: 1770 IILENFSVATEESTE 1784



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521



 Score =  136 bits (342), Expect = 3e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237

Query: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471

Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508

Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568

Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621

Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681

Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741

Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795

Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847

Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892

Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  120 bits (301), Expect = 2e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)

Query: 1543 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1588
            ++R L    V+ S       S  +C P ++  ++ R L+   C                 
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1768
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1769 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939

Query: 1829 KHLEESNKEAKEEAELEAELELEM 1852
                  N  A +E      L+L +
Sbjct: 940  SSFSADNLTAPDEDREMNNLQLAL 963



 Score =  104 bits (260), Expect = 9e-22
 Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)

Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214

Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274

Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
                     F    G                                D     N SD   
Sbjct: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334

Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383

Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443

Query: 1543 KRRNLMLDDV 1552
            +   L +  V
Sbjct: 444  EHEALTIRGV 453



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398

Query: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458

Query: 953  YVLFNLLVAILVEGFQAE 970
            +   NL + ++++ F  +
Sbjct: 1459 FFTLNLFIGVIIDNFNQQ 1476



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698

Query: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758

Query: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174

Query: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229

Query: 1694 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1738
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289

Query: 1739 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1758
                VE  G      DL                            C E + C   G    
Sbjct: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349

Query: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401

Query: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score =  442 bits (1137), Expect = e-123
 Identities = 329/1155 (28%), Positives = 561/1155 (48%), Gaps = 117/1155 (10%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
            F A+   A   + E +    +L     G    K+     C  L  L + P+   +L    
Sbjct: 942  FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999

Query: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
             LP  I    ATP S P   +    E + P  + T      +PG     +  P       
Sbjct: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046

Query: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
             P + A S T        NSLG      +               QESQ      E    S
Sbjct: 1047 VPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVSGGPEAPPDS 1091

Query: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
               S      S E EA +S    D  Q       A G G   E     G +A       L
Sbjct: 1092 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1149

Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
                P L  D  D E   ++G         R P C ++       ++    R R  C+ I
Sbjct: 1150 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1200

Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
            + H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA 
Sbjct: 1201 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1260

Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
            G+    + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +
Sbjct: 1261 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1313

Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
            SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N
Sbjct: 1314 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1373

Query: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
             T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G 
Sbjct: 1374 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1433

Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLR 1538
            ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE    
Sbjct: 1434 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE---- 1489

Query: 1539 RLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1598
              +KK  N M              S+   KP     ++++  +  + T    D+ I  +I
Sbjct: 1490 --QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLI 1537

Query: 1599 GLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
             LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D 
Sbjct: 1538 CLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1595

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
             +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +L
Sbjct: 1596 VVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1653

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            P + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T
Sbjct: 1654 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1708

Query: 1778 GDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1825
               W+G++   L      CD            C +  +  ++F ++++ +  ++VN+ IA
Sbjct: 1709 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1768

Query: 1826 VLMKHLEESNKEAKE 1840
            +++++   + +E+ E
Sbjct: 1769 IILENFSVATEESTE 1783



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520



 Score =  132 bits (332), Expect = 4e-30
 Identities = 195/900 (21%), Positives = 352/900 (39%), Gaps = 203/900 (22%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237

Query: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471

Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508

Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568

Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621

Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681

Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741

Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795

Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847

Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892

Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  118 bits (296), Expect = 6e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)

Query: 1543 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1588
            ++R L    V+ S       S  +C P ++  ++ R L+   C                 
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1768
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1769 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939

Query: 1829 KHLEESNKEAKEEAELEAELELEM 1852
                  N  A +E      L+L +
Sbjct: 940  SSFSADNLTAPDEDREMNNLQLAL 963



 Score =  103 bits (257), Expect = 2e-21
 Identities = 89/370 (24%), Positives = 156/370 (42%), Gaps = 79/370 (21%)

Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214

Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274

Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
                     F    G                                D     N SD   
Sbjct: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334

Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383

Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443

Query: 1543 KRRNLMLDDV 1552
            +   L +  V
Sbjct: 444  EHEALTIRGV 453



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1159 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1217

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1218 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1277

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1278 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1337

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1338 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1397

Query: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 1398 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1457

Query: 953  YVLFNLLVAILVEGFQAE 970
            +   NL + ++++ F  +
Sbjct: 1458 FFTLNLFIGVIIDNFNQQ 1475



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1582

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1583 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1641

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1642 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1697

Query: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1698 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1757

Query: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 1758 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1790



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174

Query: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229

Query: 1694 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1738
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289

Query: 1739 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1758
                VE  G      DL                            C E + C   G    
Sbjct: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349

Query: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401

Query: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1529 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1581

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1582 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1640

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1641 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score =  430 bits (1106), Expect = e-120
 Identities = 313/1141 (27%), Positives = 556/1141 (48%), Gaps = 142/1141 (12%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970

Query: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023

Query: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069

Query: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110

Query: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161

Query: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217

Query: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274

Query: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334

Query: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394

Query: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDV 1552
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE      +KK  N M    
Sbjct: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE------QKKYYNAM---- 1444

Query: 1553 IASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQ 1611
                      S+   KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q
Sbjct: 1445 ------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ 1498

Query: 1612 QPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEE 1671
             P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +
Sbjct: 1499 SPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSD 1556

Query: 1672 IEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLF 1731
            I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ 
Sbjct: 1557 I--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1614

Query: 1732 FIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD 1791
            FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G++   L  
Sbjct: 1615 FIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1669

Query: 1792 ----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK 1839
                CD            C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ 
Sbjct: 1670 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1729

Query: 1840 E 1840
            E
Sbjct: 1730 E 1730



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1309 CINQTEGDLPL------------------------------------------------- 1319

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467



 Score =  136 bits (342), Expect = 3e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237

Query: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471

Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508

Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568

Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621

Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681

Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741

Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795

Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847

Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892

Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  120 bits (301), Expect = 2e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)

Query: 1543 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1588
            ++R L    V+ S       S  +C P ++  ++ R L+   C                 
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1768
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1769 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939

Query: 1829 KHLEESNKEAKEEAELEAELELEM 1852
                  N  A +E      L+L +
Sbjct: 940  SSFSADNLTAPDEDREMNNLQLAL 963



 Score =  104 bits (260), Expect = 9e-22
 Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)

Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214

Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274

Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
                     F    G                                D     N SD   
Sbjct: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334

Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383

Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443

Query: 1543 KRRNLMLDDV 1552
            +   L +  V
Sbjct: 444  EHEALTIRGV 453



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061

Query: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121

Query: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180

Query: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240

Query: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300

Query: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360

Query: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420

Query: 969  AE 970
             +
Sbjct: 1421 QQ 1422



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644

Query: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704

Query: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174

Query: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229

Query: 1694 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1738
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289

Query: 1739 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1758
                VE  G      DL                            C E + C   G    
Sbjct: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349

Query: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401

Query: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score =  419 bits (1078), Expect = e-116
 Identities = 317/1138 (27%), Positives = 550/1138 (48%), Gaps = 120/1138 (10%)

Query: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730

Query: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790

Query: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849

Query: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFF 983
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+          +  
Sbjct: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD----------NLT 899

Query: 984  SPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEA-LGP 1041
            +P  DG+  + +  LA + +  H   +++L       + + P   PK+    + +  L  
Sbjct: 900  APEDDGEVNNLQVALARIQVFGH-RTKQALCS---FFSRSCPFPQPKAEPELVVKLPLSS 955

Query: 1042 ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-WTSRRSSRNSLGRAPSLKRRS 1100
            +      + +   G++  +++P   R   HS + A  + W S   +    G +       
Sbjct: 956  SKAENHIAANTARGSSGGLQAPRGPRDE-HSDFIANPTVWVSVPIAE---GESDLDDLED 1011

Query: 1101 PSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTL----- 1155
              GE       E      +E+  + ER      DH    S      SS DL  +L     
Sbjct: 1012 DGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTPRS-PGTGTSSEDLAPSLGETWK 1066

Query: 1156 -----QVP--GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLS 1208
                 QVP  G+  T+S  GS     DC       R    L  D    + DD   EG + 
Sbjct: 1067 DESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKIPELADDLE--EPDDCFTEGCIR 1121

Query: 1209 KGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLN 1266
                         P C L+  +  W         + R  C+RI+ H  F+  ++ +I L+
Sbjct: 1122 -----------HCPCCKLDTTKSPWDV-----GWQVRKTCYRIVEHSWFESFIIFMILLS 1165

Query: 1267 CITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326
              ++A E   +D     +  L  ++ +FT +F+ EM +K VA G+    + Y  ++W  L
Sbjct: 1166 SGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWL 1221

Query: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386
            D L+V IS+I +   ++  S    +  ++ LR LR LRPLR +SR +G+++VV+ L+ ++
Sbjct: 1222 DFLIVNISLISLTAKILEYSE---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278

Query: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDT----RNITNKSDC----AE 1434
              I N++++C  F++IF I+GV LF GKF+ C     GE +      + NKSDC    + 
Sbjct: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338

Query: 1435 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1494
             S+ WV  K NFDN+    ++L  +A+  GW+DIMY  +D+  V+ QP    N +M LYF
Sbjct: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398

Query: 1495 ISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIA 1554
            + F++   FF LN+FVGV+++NF++ ++    ++    EE      +KK  N M      
Sbjct: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEE------QKKYYNAM------ 1446

Query: 1555 SGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ 1614
                    S+   KP     ++F+  V  + T    D+ I  +I LN++TM +E   Q +
Sbjct: 1447 ----KKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSE 1502

Query: 1615 ILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEV 1674
               + L   N  F  +F  E V K+ A   + +F + WN  D  +V+LSI  +    I  
Sbjct: 1503 EKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILK 1561

Query: 1675 NASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIF 1734
            +     +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI+
Sbjct: 1562 SLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1621

Query: 1735 AALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD--- 1791
            +  G+  F  +  +      G+     F+ F  + L LF+++T   W+G++   L     
Sbjct: 1622 SIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP 1676

Query: 1792 -CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840
             CD            C +  +  I+F ++++ +  ++VN+ IAV++++   + +E+ E
Sbjct: 1677 YCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734



 Score =  149 bits (375), Expect = 4e-35
 Identities = 186/876 (21%), Positives = 350/876 (39%), Gaps = 168/876 (19%)

Query: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155

Query: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213

Query: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273

Query: 889  -------------CKFASERDGDTLPDRK------------------------------- 904
                           ++S R  D   +++                               
Sbjct: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333

Query: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
                +FDS  WA +++F+++TQ+ W ++    + ++     ++F+ ++  G++ L NL++
Sbjct: 334  FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL 393

Query: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIH 1019
            A++   ++ +  A   E E            ++K   AL  L +  E+  +L +    +H
Sbjct: 394  AVVTMAYEEQNQATTDEIEAK----------EKKFQEALEMLRKEQEVLAALGIDTTSLH 443

Query: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1079
            +        K+ S           RR         G+  + KSP S   +         +
Sbjct: 444  SHNGSPLTSKNAS----------ERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLA 493

Query: 1080 WTSRRSSRNSLG--RAPSLKRRSPSG-------------ERRSLLSGEGQESQDEEESSE 1124
               RR+S  S+   R+P      P G              R SLL G G   Q     S 
Sbjct: 494  SGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSP 553

Query: 1125 EERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQD--CNGKSAS 1182
              +  P+  D RH     +   +S   P  + V            ++E+ D     + A 
Sbjct: 554  LPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAM 611

Query: 1183 GRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRF 1242
              ++      +   + +        S  ++   W       CC           P   + 
Sbjct: 612  SVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW------DCC-----------PMWVKL 654

Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
            + +   ++T    +  + + I +N I +AME   + P       L + N +FT  F AEM
Sbjct: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEM 712

Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
              K++A    F    Y +  WN+ D ++V +S++++        G    G L VLR  R 
Sbjct: 713  VFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL--------GVAKKGSLSVLRSFRL 760

Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
            LR  ++      L  +++ + +S+  +GN+ +I      +F ++G QL         GE+
Sbjct: 761  LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GEN 812

Query: 1423 TRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ 1481
             RN  N+ + +     W R H ++F      L+   +L  +  W++ M+  ++   V Q+
Sbjct: 813  YRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRILCGE--WIENMWACME---VGQK 863

Query: 1482 PIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
             I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 864  SI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893



 Score =  128 bits (321), Expect = 7e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197

Query: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251

Query: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310

Query: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298
              +    FSL PLS+                       N    C+               
Sbjct: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333

Query: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371

Query: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431

Query: 406  SQLMREQRVRFLSNASTLAS 425
               M E++ ++ +    L S
Sbjct: 1432 DIFMTEEQKKYYNAMKKLGS 1451



 Score =  118 bits (296), Expect = 6e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166

Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224

Query: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280

Query: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330

Query: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371

Query: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418



 Score =  106 bits (264), Expect = 3e-22
 Identities = 80/348 (22%), Positives = 149/348 (42%), Gaps = 67/348 (19%)

Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159

Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213

Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270

Query: 1414 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1437
                                                  +C  G D+ +  +   C + S 
Sbjct: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330

Query: 1438 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1497
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380

Query: 1498 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR 1545
            + + +F+++N+ + VV   + +  Q    +E   +E+K    LE  R+
Sbjct: 381  IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRK 427



 Score =  105 bits (261), Expect = 7e-22
 Identities = 81/317 (25%), Positives = 149/317 (47%), Gaps = 36/317 (11%)

Query: 1542 KKRRNLMLDDVIASGSSASAASEAQCKPYYSDYS-------------RFRLLVHHLCTSH 1588
            + +R + +  +I S       SE +C P  +  S             + + ++  L T  
Sbjct: 606  RAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDP 665

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
            + +L IT  I +N + MAMEH+      +  L+I N +FT+ F  E VFK++AF    +F
Sbjct: 666  FAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYF 725

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
            Q +WN  D  IV +S++ + + +             + ++R  R+ RV KL K    +  
Sbjct: 726  QKKWNIFDCIIVTVSLLELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNT 775

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRN 1764
            L+  +  ++  +GNL ++  ++ F+FA +G +L G+   +     + P E   R     +
Sbjct: 776  LIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHD 834

Query: 1765 FGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVI 1824
            F  +FL +FR+  G+ W   M   + +  Q+S C       I F++ ++    V++N+ I
Sbjct: 835  FFHSFLIVFRILCGE-WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFI 886

Query: 1825 AVLMKHLEESNKEAKEE 1841
            A+L+      N  A E+
Sbjct: 887  ALLLNSFSADNLTAPED 903



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 102/441 (23%), Positives = 181/441 (41%), Gaps = 118/441 (26%)

Query: 1552 VIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ 1611
            V+  G + S  S  +    +S ++  R     +    +  LFIT  I +N V M      
Sbjct: 94   VLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD-- 151

Query: 1612 QPQILDEALKICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGI 1667
                L E ++   Y+FTVI+  E++ K++A GF      + +D WN LD +++ L+ +G 
Sbjct: 152  ----LPEKIE---YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGT 204

Query: 1668 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1727
             ++   ++            +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L 
Sbjct: 205  AIDLRGISG-----------LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILT 253

Query: 1728 MLLFFIFAALGVELF----------GDLECDET--------------------------- 1750
            +    +FA +G++LF           D+  +ET                           
Sbjct: 254  IFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNG 313

Query: 1751 ----HPCEGL----------GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQES 1796
                H  +G             + +F +F  AFL+LFR+ T D+W  + + TLR   +  
Sbjct: 314  SDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK-- 371

Query: 1797 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK------EAKE---------- 1840
                  I  I+FV  +    F LVN+++AV+    EE N+      EAKE          
Sbjct: 372  ------IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEML 425

Query: 1841 --EAELEAELELEMKTLSPQPHSPLGSP-------FLWPGVEGPDSPDSPKPGA------ 1885
              E E+ A L ++  +L     SPL S         + P V    + D+  P +      
Sbjct: 426  RKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQR 485

Query: 1886 ----LHPAAHARSASHFSLEH 1902
                L  A+  R ASH S+ H
Sbjct: 486  RMSFLGLASGKRRASHGSVFH 506



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 36/275 (13%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646

Query: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706

Query: 949  TFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
                 ++ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDF 1741



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 45/281 (16%)

Query: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203

Query: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263

Query: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323

Query: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383

Query: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
                   + +  LYF+  + FG +   NL V ++++ F  +
Sbjct: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530

Query: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589

Query: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684

Query: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738

Query: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797

Query: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250
            F+F +VG QL     RN     +N S P
Sbjct: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score =  345 bits (884), Expect = 4e-94
 Identities = 198/607 (32%), Positives = 338/607 (55%), Gaps = 45/607 (7%)

Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
            R  C++I+ H  F+  ++ +I L+   +  E   ++     +  L  ++ IFT +F+ EM
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105

Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
             +K VA G  FG+  Y  S+W  LD ++V++SV  ++  M           L+  R LR 
Sbjct: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151

Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1421
            LRPLR +S+ +G+K+VV  L+ ++  I N++++C  F+++F ILGV  F GKF  C  G 
Sbjct: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211

Query: 1422 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
            D+      ITNKS C   ++ W+  K NFDN+G A ++L  +A+  GW+DI+Y  +D+  
Sbjct: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
             +QQP    N    +YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE   
Sbjct: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEE--- 1328

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
               +KK  N M              S+   KP     ++ + LV  + TS   D+ I  +
Sbjct: 1329 ---QKKYYNAM----------KKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISL 1375

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            I LN+++M  E Y QP+ +   L   N++F VIF LE + K+ A   + +F + WN  D 
Sbjct: 1376 IILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDC 1434

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
             +VLLSI+   +  +E    +P  PT+ RI+R+ RI R+L+L++ A G+R LL  +M +L
Sbjct: 1435 VVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSL 1494

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            P + N+GLL  L+ FI+A LG+  F      + +P  G+     F+ F  + L LF++ST
Sbjct: 1495 PSLFNIGLLLFLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQIST 1549

Query: 1778 GDNWNGIMKDTLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEE 1833
               W+ ++   LR    C+  S  C+   I+  YFVS+++ +  ++VN+ IAV++++   
Sbjct: 1550 SAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNT 1609

Query: 1834 SNKEAKE 1840
            + +E+++
Sbjct: 1610 ATEESED 1616



 Score =  125 bits (315), Expect = 4e-28
 Identities = 76/270 (28%), Positives = 141/270 (52%), Gaps = 22/270 (8%)

Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
           W  +    R ++   +    I I I++NT+ + +E+H+        L I N+VFTS+F  
Sbjct: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622

Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
           EM LK++   P+ Y +  +NIFD ++ ++S  +++    Q      LR+FR++RV KL +
Sbjct: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682

Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
             P L   + ++  ++  + +  ++L++ IFIFS++GM LFG  F S++        G T
Sbjct: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742

Query: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
           +   +++       + + VF+IL  E W + ++  M    ++SS   + FI +   G  V
Sbjct: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801

Query: 955 LFNLLVAILVEGF-------QAEGDANKSE 977
           + NL +A+L+  F         EG+A K++
Sbjct: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTK 831



 Score =  116 bits (290), Expect = 3e-25
 Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           RS  +R   +  F    +  +++NCV +    P ++   +S    I +     I+ F   
Sbjct: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172

Query: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
           E ++K++A G I  +  +L D WN LD  ++   ++ Y   +  +    +RT RV R L+
Sbjct: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231

Query: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
           AI+ V  ++++V  LL ++  L NV++L FF   IF +VG QL+ G L  +C        
Sbjct: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283

Query: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
            +S D +     E  D     C + +EN    + C       G   G   C + YE    
Sbjct: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327

Query: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
                          C   + NP     NFDN G++++A+F+++T + W  +    +   
Sbjct: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372

Query: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
             Y+  +FI++I +GSF++INL L V+   + E
Sbjct: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405



 Score =  114 bits (285), Expect = 1e-24
 Identities = 83/349 (23%), Positives = 166/349 (47%), Gaps = 55/349 (15%)

Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
            +IF P +  R L  R+  H +F   ++  + +NC+ +A    K    ++      ++  +
Sbjct: 110  FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165

Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
            FT +++ E  +K++A G+   E ++LR  WN LD +++ I++    VS +     K+L  
Sbjct: 166  FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220

Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            LR  R+ R L+ + V+SR   LK++V  L+ S+K + N++++      IF ++G QLF G
Sbjct: 221  LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277

Query: 1414 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1444
                 C   D +NI+N                          S C+   E  +  +   Y
Sbjct: 278  SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337

Query: 1445 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1501
               NFDN G + +++F L ++D W  +    L   G+          + + +FI  + + 
Sbjct: 338  NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387

Query: 1502 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRRNLML 1549
            +F+++N+ + VV   + +  ++   E EA+ +  +  ++L K+ +  ++
Sbjct: 388  SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALV 436



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)

Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
            P ++ + L   I+T ++FD +++ +I LN I++  E    +   A +  L   N++F  +
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408

Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1355
            F  E  +K+ AL      Q Y  + WN+ D ++VL+S++  ++S + +         + R
Sbjct: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463

Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
            ++RL R  R LR++  A+G++ ++  LM SL  + NI ++      I+ ILG+  F    
Sbjct: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520

Query: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
                      +  +S   +         +NF     +++ LF +++  GW  ++   L +
Sbjct: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563

Query: 1476 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
                     N H P +   YF+S+++I    V+NM++ V++ENF+   +  E+
Sbjct: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616



 Score =  102 bits (255), Expect = 3e-21
 Identities = 71/266 (26%), Positives = 129/266 (48%), Gaps = 22/266 (8%)

Query: 1586 TSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFR 1645
            T  + +L IT  I +N V +AMEH++     ++ L I N +FT IF+ E   K++A    
Sbjct: 575  TDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPY 634

Query: 1646 RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVG 1705
             +F+  WN  D  + LLS   + +  +    S P        +R  R+ RV KL K    
Sbjct: 635  HYFRRGWNIFDSIVALLSFADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPT 686

Query: 1706 MRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--------DLECDETHPCEGLG 1757
            +  L+  +  ++  +G+L ++ +++ FIF+ +G++LFG           C+ T P     
Sbjct: 687  LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCL 746

Query: 1758 RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1817
            RH    +F  +FL +FR+  G+ W     + + +C QE+   ++ +  I F+   +  + 
Sbjct: 747  RHWHMGDFWHSFLVVFRILCGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKL 800

Query: 1818 VLVNVVIAVLMKHLEESNKEAKEEAE 1843
            V++N+ IA+L+       +    E E
Sbjct: 801  VVLNLFIALLLNSFSNEERNGNLEGE 826



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 75/267 (28%), Positives = 133/267 (49%), Gaps = 28/267 (10%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV S+ F   I+  I++N +SM  E + QP+ + + L+  N VF  +F LE L+K+    
Sbjct: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421

Query: 799  PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
             + Y  N +N+FD V+V++S+           E +        ++R  R+ R+L+LVR  
Sbjct: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
              ++  L  LM ++ ++    +LL L +FI++ILGM+ F  K   E   D + + K F S
Sbjct: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-KVNPESGIDDIFNFKTFAS 1539

Query: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
               +++ +FQI T   W+ +L   + S  S             A  YF++ +     ++ 
Sbjct: 1540 ---SMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596

Query: 957  NLLVAILVEGFQ-AEGDANKSESEPDF 982
            N+ +A+++E F  A  ++     E DF
Sbjct: 1597 NMYIAVILENFNTATEESEDPLGEDDF 1623



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 65/278 (23%), Positives = 131/278 (47%), Gaps = 41/278 (14%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
            W  +  T  +IV   +F   I+  IL+++ ++  E  + E   ++   L  ++I+FT +F
Sbjct: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101

Query: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
             LEM+LK + +G   Y  + +   D +IV++SV  ++      L  L++FR +R L+ +R
Sbjct: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156

Query: 847  FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
             L   +   VV   L+  +  +    ++ ++F  +F ILG++ F  KF    +G      
Sbjct: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216

Query: 898  ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
                             +  + NFD++  A + + Q+ T + W  ++Y  + ST      
Sbjct: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276

Query: 937  ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
                +S   +YF+  + FG++   NL + ++++ F  +
Sbjct: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314



 Score = 88.6 bits (218), Expect = 7e-17
 Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)

Query: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
            R  C + V + WFE   + VILL+   L      ED+  ++Q + + L    D IF   F
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101

Query: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
             +EMV+K VA G FGK  Y    W  LDF IVI  +      ++  SF   RT+R LRPL
Sbjct: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155

Query: 189  RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
            RA+++   M+++V  L+  +P + NVLL+C   + +F I+GV  ++G
Sbjct: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)

Query: 1571 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1630
            +  ++  R L   +       +FI G + +N V MA    +     +  +  C  +FT I
Sbjct: 112  FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169

Query: 1631 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1682
            ++ E++ K++A GF      F +D WN LD  ++ ++I+    GIT++ +          
Sbjct: 170  YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220

Query: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
                 +R  R+ R LK + +   ++ ++  +++++ ++ N+ +L      IFA +G +LF
Sbjct: 221  -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275

Query: 1743 ------------------------------------------GDLECDETHPCEGLG--- 1757
                                                      G+  C   + C+      
Sbjct: 276  MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335

Query: 1758 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1815
               +  F NFG +FL +FR+ T D+W  + + TLR           + S  +F+  +   
Sbjct: 336  DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387

Query: 1816 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1855
             F L+N+ +AV+    EE NK    E E + ++  E + L
Sbjct: 388  SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 66/284 (23%), Positives = 135/284 (47%), Gaps = 28/284 (9%)

Query: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
            ++T    +  + + I +N + +AME  K++  S E++ L + N +FT++F+AEM +K++A
Sbjct: 573  VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630

Query: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
            L        Y R  WN+ D ++ L+S  D++  ++       L   RVLR+ +  +    
Sbjct: 631  LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686

Query: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
                  L  +++ + +S+  +G++ V+      IF ++G+QLF   F   +     N T 
Sbjct: 687  ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740

Query: 1429 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1488
                   +   +RH +  D     L+   +L  +  W++ M++ +             + 
Sbjct: 741  ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785

Query: 1489 WMLLYFISFLLIVAFFVLNMFVGVVVENF-HKCRQHQEEEEARR 1531
              ++ FI   +I    VLN+F+ +++ +F ++ R    E EAR+
Sbjct: 786  LCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARK 829



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 56/260 (21%), Positives = 117/260 (45%), Gaps = 52/260 (20%)

Query: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
           +N  +I+  VFT ++  E L+K+L  G     F ++++P+N  D +++ I++   +    
Sbjct: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215

Query: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
             L  LRTFR+ R LK +  +  L+  +  L++++  +    +L    + IF+++G  LF
Sbjct: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275

Query: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
                       CK  S  +         +  P+ K                        
Sbjct: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335

Query: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
                NFD+  W+ + +F+++TQ+ W K+    + +T  ++  +FI ++  G++ L NL 
Sbjct: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395

Query: 960 VAILVEGFQAEGDANKSESE 979
           +A++   ++ +     +E E
Sbjct: 396 LAVVTMAYEEQNKNVAAEIE 415



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            + C +G  +     +NFDN+G A++A+ QV T +GW+DI+Y  +D+           +  
Sbjct: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
             +IYF++ II GSFF +NL + VI   F++ +++   +   M E++ ++ +    L S
Sbjct: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)

Query: 63  YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
           YL  +  P+  C    LRTV  +P+ E    + I++N V L M    E    ++   ++L
Sbjct: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609

Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
              +    + F  EM +K++AL  +    Y    WN  D  + +    +  +  LQ  S+
Sbjct: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666

Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             +R+ RVLR  +     P++  L+ ++ +++  LG++ ++   V FIF +VG+QL+
Sbjct: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+ I + +I+LN +++      +  A  S    IL   +      F +E ++K+ AL   
Sbjct: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
             ++ Y  + WN  D  +V+  ++   +  L+N          F  VR  R+ R LR +  
Sbjct: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479

Query: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
               +R L+  L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
           ++++ +F+++  E W++ M+  M   +A S    I FIL+ ++G   ++NL + ++   F
Sbjct: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814

Query: 399 SETKQRESQLMREQR 413
           S  ++R   L  E R
Sbjct: 815 S-NEERNGNLEGEAR 828


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score =  330 bits (847), Expect = 8e-90
 Identities = 205/676 (30%), Positives = 359/676 (53%), Gaps = 62/676 (9%)

Query: 1193 DPPLDGDDADDEGNLSKGERVRAWIR----ARLPACCLERDSWSAYIFPPQSRFRLLCHR 1248
            D PL G+  + E      +   A        R   C +  +S    I+      R  C++
Sbjct: 1120 DNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIW---WNIRKTCYK 1176

Query: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
            I+ H  F+  ++++I L+   +A E   I+     +I L  ++ IFT +F+ EM +K +A
Sbjct: 1177 IVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA 1236

Query: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
             G+    + Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR LRPLR 
Sbjct: 1237 YGY----KTYFTNAWCWLDFLIVDVSLVTLVANTL---GYSDLGPIKSLRTLRALRPLRA 1289

Query: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED------ 1422
            +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C          
Sbjct: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFP 1349

Query: 1423 TRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
               + N+S+C        + RW   K NFDN+G   +SL  +A+  GW  IMY  +D+V 
Sbjct: 1350 ASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVN 1409

Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
            VD+QP   ++ +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE   
Sbjct: 1410 VDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE--- 1466

Query: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
               +KK  N M              S+   KP     ++ +  +  L T+   D+ I  +
Sbjct: 1467 ---QKKYYNAM----------KKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVL 1513

Query: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
            I LN+VTM +E   Q Q + E L   N +F ++F  E V KL++     +F   WN  D 
Sbjct: 1514 ICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDF 1572

Query: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
             +V++SI+G+ L ++    +  ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +L
Sbjct: 1573 VVVIISIVGMFLADL--IETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSL 1630

Query: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
            P + N+GLL  L+ FI+A  G+  F  ++ +     +G+     F  FG + + LF+++T
Sbjct: 1631 PALFNIGLLLFLVMFIYAIFGMSNFAYVKKE-----DGINDMFNFETFGNSMICLFQITT 1685

Query: 1778 GDNWNGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVI 1824
               W+G++   L     DCD          E  C N  +   YFVS+++ +  V+VN+ I
Sbjct: 1686 SAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYI 1745

Query: 1825 AVLMKHLEESNKEAKE 1840
            AV++++   + +E+ E
Sbjct: 1746 AVILENFSVATEESTE 1761



 Score =  156 bits (395), Expect = 2e-37
 Identities = 204/914 (22%), Positives = 370/914 (40%), Gaps = 208/914 (22%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV- 796
            KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 121  KILVHSLFSMLIMCTILTNCIFMTMN---NPPDWTKNVEYT---FTGIYTFESLVKILAR 174

Query: 797  ---YGPFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
                G F ++++P+N  D V++V + + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 175  GFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLK 232

Query: 853  RQLVVLMKTMDNVA------TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKN- 905
              +  L++++  ++       FC+ +   I +   +G     C   S  + +TL    N 
Sbjct: 233  TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNT 292

Query: 906  ---------------------------------------------------FDSLLWAIV 914
                                                               FD+  WA +
Sbjct: 293  LESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFL 352

Query: 915  TVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDAN 974
             +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++   ++ +  AN
Sbjct: 353  ALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412

Query: 975  KSESEPDF--FSPSLDG---DGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPK 1029
              E++     F   LD    + +  + +A  +  E+  +R+S +  L   ++ T     K
Sbjct: 413  IEEAKQKELEFQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGLSESSSETSKLSSK 471

Query: 1030 STST-------------GLGEALGPASRRTSSSG-------SAEPGAAHEMKSPPSARSS 1069
            S                  GE  G A + + S         S   G     ++     S+
Sbjct: 472  SAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLST 531

Query: 1070 PH-SPWSAASS-WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1127
            P+ SP S   S +++RRSSR SL                    G G++   E E +++E 
Sbjct: 532  PNQSPLSIRGSLFSARRSSRTSLFS----------------FKGRGRDIGSETEFADDEH 575

Query: 1128 ASPAGSDHRHRGSL----EREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNG--KSA 1181
             S  G +   RGSL      + + S ++    + P +       G      DCNG     
Sbjct: 576  -SIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPV---NGKMHSAVDCNGVVSLV 631

Query: 1182 SGRLARAL-----------------RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPAC 1224
             GR A  L                 R     L  +D  ++ NL    R RA  RA +   
Sbjct: 632  DGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNL----RQRAMSRASILTN 687

Query: 1225 CLERDSWSAYIFPPQ-----------------SRFRLLCHRIITHKMFDHVVLVIIFLNC 1267
             +E    S    PP                   +F+   + I+     D  + + I LN 
Sbjct: 688  TVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNT 747

Query: 1268 ITIAMERPKIDPHSAE-RIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326
            + +AME     P + E +  L + N +FT +F AEM +K++A+        Y +  WN+ 
Sbjct: 748  LFMAMEH---HPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD----PYEYFQVGWNIF 800

Query: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386
            D L+V +S++++ ++ V          L VLR  R LR  ++      L ++++ + +S+
Sbjct: 801  DSLIVTLSLVELFLADVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 852

Query: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFF---VCQGEDTRNITNKSDCAEASYRWVRHK 1443
              +GN+ ++      IF ++G+QLF GK +   VC+  D        DC     RW  H 
Sbjct: 853  GALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIND--------DCTLP--RW--HM 899

Query: 1444 YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAF 1503
             +F +    L+   VL  +  W++ M+D ++  G             L+ ++  ++I   
Sbjct: 900  NDFFH--SFLIVFRVLCGE--WIETMWDCMEVAG---------QAMCLIVYMMVMVIGNL 946

Query: 1504 FVLNMFVGVVVENF 1517
             VLN+F+ +++ +F
Sbjct: 947  VVLNLFLALLLSSF 960



 Score =  144 bits (364), Expect = 8e-34
 Identities = 84/248 (33%), Positives = 141/248 (56%), Gaps = 8/248 (3%)

Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
           IV   +    I I I++NTL M +E+H   EE  N L I N+VFT +FA EM+LKL+   
Sbjct: 729 IVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD 788

Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVL 858
           P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  P L   + ++
Sbjct: 789 PYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKII 848

Query: 859 MKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRKNFDSLLWAIV 914
             ++  +    ++L + +FIF+++GM LFG  +        D  TLP R + +    + +
Sbjct: 849 GNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RWHMNDFFHSFL 907

Query: 915 TVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDA 973
            VF++L  E W + +++ M  +  +   + ++ +M  GN V+ NL +A+L+  F ++ + 
Sbjct: 908 IVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD-NL 965

Query: 974 NKSESEPD 981
              E +PD
Sbjct: 966 TAIEEDPD 973



 Score =  140 bits (352), Expect = 2e-32
 Identities = 114/378 (30%), Positives = 177/378 (46%), Gaps = 92/378 (24%)

Query: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128
            R  C + V + WFE   +L+ILL+   L      EDI  + ++  +I+  + D IF + F
Sbjct: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAF----EDIYIERKKTIKIILEYADKIFTYIF 1226

Query: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181
             +EM++K +A   +G K Y  + W  LDF IV       +A  L YS DL  +   ++RT
Sbjct: 1227 ILEMLLKWIA---YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYS-DLGPIK--SLRT 1280

Query: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG      
Sbjct: 1281 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG------ 1334

Query: 242  FLPENFSLPLSVDLERYYQTEN-EDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
                           ++Y+  N  D S F  SQ                      P    
Sbjct: 1335 ---------------KFYECINTTDGSRFPASQV---------------------PNRSE 1358

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
             +   N S N   V W                  +NFDN+G  ++++ QV T +GW  IM
Sbjct: 1359 CFALMNVSQN---VRWKNL--------------KVNFDNVGLGYLSLLQVATFKGWTIIM 1401

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          +S Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1402 YAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1461

Query: 408  LMREQRVRFLSNASTLAS 425
             M E++ ++ +    L S
Sbjct: 1462 FMTEEQKKYYNAMKKLGS 1479



 Score =  130 bits (326), Expect = 2e-29
 Identities = 112/480 (23%), Positives = 202/480 (42%), Gaps = 62/480 (12%)

Query: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116
           A    + LS  S  R   ++ + +  F  + M  IL NC+ + M  P +           
Sbjct: 102 ATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPD----------W 151

Query: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175
            +  +      +  E +VK++A G   G+  +L D WN LDF +++   L   ++L NVS
Sbjct: 152 TKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVS 211

Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 212 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269

Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
            L+++CF     +      +    ++E +    F   +  ++ +                
Sbjct: 270 NLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALL--------------- 314

Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
             CG   ++       TCV   +          NP  G  +FD   +A++A+F+++T + 
Sbjct: 315 --CGFSTDSGQCPEGYTCVKIGR----------NPDYGYTSFDTFSWAFLALFRLMTQDY 362

Query: 356 WVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVR 415
           W ++    + A      I+F+++I +GSF++INL L V+A  + E  Q   +  +++ + 
Sbjct: 363 WENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELE 422

Query: 416 FLSNASTLASFSEPGSC-------YEELLKYLVYILRKAARRLAQVS---------RAAG 459
           F      L    E           Y  + +  +  L +++   +++S         R   
Sbjct: 423 FQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKK 482

Query: 460 VRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASP 519
                LSS    G  E    S    S RR S H  V  H   H         L  P  SP
Sbjct: 483 KNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEK------RLSTPNQSP 536



 Score =  114 bits (286), Expect = 8e-25
 Identities = 88/357 (24%), Positives = 159/357 (44%), Gaps = 75/357 (21%)

Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
            Y+  P S  R +  +I+ H +F  +++  I  NCI + M  P     + E        Y 
Sbjct: 107  YMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVE--------YT 158

Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
            FT ++  E  VK++A G+C GE  +LR  WN LD ++++ + +   V+         LG 
Sbjct: 159  FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---------LGN 209

Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 210  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269

Query: 1414 K--------------------------------FFVCQGEDTRNI----TNKSDCAEASY 1437
                                             F+  +G     +    T+   C E  Y
Sbjct: 270  NLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPE-GY 328

Query: 1438 RWVRHKYN-------FDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWM 1490
              V+   N       FD    A ++LF L ++D W ++    L A G             
Sbjct: 329  TCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG----------KTY 378

Query: 1491 LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRRE---EKRLRRLEKKR 1544
            +++F+  + + +F+++N+ + VV   + +  Q    EEA+++E   ++ L RL+K++
Sbjct: 379  MIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQ 434



 Score =  114 bits (284), Expect = 1e-24
 Identities = 82/279 (29%), Positives = 137/279 (49%), Gaps = 27/279 (9%)

Query: 1567 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1626
            C PY+    +F+  ++ +    ++DL IT  I LN + MAMEH+   +     L I N +
Sbjct: 715  CSPYWI---KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLV 771

Query: 1627 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1686
            FT IF  E V KL+A     +FQ  WN  D  IV LS++ + L ++E           + 
Sbjct: 772  FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG----------LS 821

Query: 1687 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1743
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 822  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 881

Query: 1744 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1802
             +  C     C     H    +F  +FL +FRV  G+ W     +T+ DC + +      
Sbjct: 882  KECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQA 931

Query: 1803 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1841
            +  I ++  ++    V++N+ +A+L+      N  A EE
Sbjct: 932  MCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE 970



 Score =  101 bits (251), Expect = 1e-20
 Identities = 84/344 (24%), Positives = 154/344 (44%), Gaps = 46/344 (13%)

Query: 672  RAGAGEVELADREMPDSDSEAVYE-FTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWR 730
            R+ + E    D  +P    EA  E    D   +   D   RR      + E      +W 
Sbjct: 1110 RSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWN 1169

Query: 731  LICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFAL 788
             I  T  KIV+  +F   I++ IL+++ ++  E  Y E+ + +   LE ++ +FT +F L
Sbjct: 1170 -IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFIL 1228

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG--GLSVLRTFRLMRVLKLVR 846
            EMLLK + YG   Y  N +   D +IV +S+  +V    G   L  +++ R +R L+ +R
Sbjct: 1229 EMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLR 1288

Query: 847  FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGDTL 900
             L   +   VV   L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG   
Sbjct: 1289 ALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRF 1348

Query: 901  PD------------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST 936
            P                         + NFD++    +++ Q+ T + W  ++Y  + S 
Sbjct: 1349 PASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSV 1408

Query: 937  ----------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
                      S +  +YF+  + FG++   NL + ++++ F  +
Sbjct: 1409 NVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 77/277 (27%), Positives = 130/277 (46%), Gaps = 41/277 (14%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            +V ++ F   IM+ I +N ++M +E   Q + +T  L   N+VF  LF  E +LKL+   
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847
             + Y    +NIFD V+V+IS   IVG     L            V+R  R+ R+L+LV+ 
Sbjct: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615

Query: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907
               ++  L  LM ++  +    +LL L +FI++I GM      FA  +  D + D  NF+
Sbjct: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEDGINDMFNFE 1671

Query: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946
            +   +++ +FQI T   W+ +L                       G     S    YF++
Sbjct: 1672 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVS 1731

Query: 947  LMTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
             +     V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 1732 YIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDF 1768



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 80/335 (23%), Positives = 140/335 (41%), Gaps = 92/335 (27%)

Query: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637
            ++LVH L       + I   I  N + M M +        +  K   Y FT I+  ES+ 
Sbjct: 121  KILVHSL-----FSMLIMCTILTNCIFMTMNNPP------DWTKNVEYTFTGIYTFESLV 169

Query: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693
            K++A GF      F +D WN LD  +++ +     L E        +N   +  +R  R+
Sbjct: 170  KILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALRTFRV 218

Query: 1694 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL------- 1745
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L       
Sbjct: 219  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278

Query: 1746 --------------------------------------------ECDETHPCEGLGR--- 1758
                                                        +C E + C  +GR   
Sbjct: 279  SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338

Query: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816
              + +F  F  AFL LFR+ T D W  + + TLR   +           I+FV  +    
Sbjct: 339  YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM--------IFFVVVIFLGS 390

Query: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELE 1851
            F L+N+++AV+    EE N+   EEA+ + ELE +
Sbjct: 391  FYLINLILAVVAMAYEEQNQANIEEAK-QKELEFQ 424



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 46/177 (25%), Positives = 93/177 (52%), Gaps = 15/177 (8%)

Query: 78  VCNPWFERISMLVILLNCVTLGM-FRPCEDIACDSQRCRILQAFDDFIFA-FFAVEMVVK 135
           V +P+ +    + I+LN + + M   P       ++  + + A  + +F   FA EMV+K
Sbjct: 730 VMDPFVDLAITICIVLNTLFMAMEHHPM------TEEFKNVLAIGNLVFTGIFAAEMVLK 783

Query: 136 MVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRTVRVLRPLRAINRV 194
           ++A+  +    Y    WN  D  IV   ++E  L D++ +S   +R+ R+LR  +     
Sbjct: 784 LIAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVEGLS--VLRSFRLLRVFKLAKSW 838

Query: 195 PSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250
           P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 839 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 895



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 46/164 (28%), Positives = 73/164 (44%), Gaps = 15/164 (9%)

Query: 78   VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
            V N  F+   M++I LN VT+ +    E          +L   +      F  E V+K++
Sbjct: 1501 VTNQAFDISIMVLICLNMVTMMV----EKEGQSQHMTEVLYWINVVFIILFTGECVLKLI 1556

Query: 138  ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRA 190
            +L    +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR 
Sbjct: 1557 SL----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRL 1612

Query: 191  INRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
            +     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1613 VKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 19/97 (19%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      Y
Sbjct: 1669 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFY 1728

Query: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 1729 FVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765


>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 20 [Homo sapiens]
          Length = 2127

 Score =  329 bits (843), Expect = 2e-89
 Identities = 228/795 (28%), Positives = 411/795 (51%), Gaps = 78/795 (9%)

Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
            ++EEE  E ++ +   S  + +  +E+ A       + +++  +  TA G    +   + 
Sbjct: 767  KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823

Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
            +    +    ++  P+ P   G++ ++E  +  G R R      L    +     SA+ I
Sbjct: 824  DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882

Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
            F   +RFRL CHRI+   +F +++L  I L+ I++A E P +   S     L  ++Y+FT
Sbjct: 883  FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941

Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
            ++F  E+ +K+ A G    + ++ R+ +N+LD L+V +S+I   +       +  + +++
Sbjct: 942  SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995

Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
            +LR+LR LRPLR I+RA+GLK VV+ +  +++ IGNIV++      +F  +GVQLFKGK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
            + C     +         IT K    +        W   K++FDN+  A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115

Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
            GW +++Y  +D+   D+ PI N+   + ++FI +++I+AFF++N+FVG V+  F    Q 
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171

Query: 1524 QEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHH 1583
            Q E+E +  E      L+K +R  +             A +A+    Y   ++ +  V +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCV-----------EYALKARPLRRYIPKNQHQYKVWY 1214

Query: 1584 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1643
            +  S Y +  +  +I LN + +AM+HY Q  +   A+ I N +FT +F +E + KL+AF 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 1644 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1703
             + +F D WN  D  IV+ SI+ I +   EVN +   +   I   R+ R+ R++KLL   
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEENSRISITFFRLFRVMRLVKLLSRG 1332

Query: 1704 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1763
             G+R LL T +++   +  + LL ++LFFI+A +G+++FG +  ++T     + R+  F+
Sbjct: 1333 EGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQ 1389

Query: 1764 NFGMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFV 1812
             F  A L LFR +TG+ W  IM   +  + C  ES   N+           +  YF+SF 
Sbjct: 1390 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFY 1449

Query: 1813 LTAQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTL 1855
            +   F+++N+ +AV+M                HL+E  +  A+ + E +  ++ L++ TL
Sbjct: 1450 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 1509

Query: 1856 SPQPHSPLGSPFLWP 1870
              +   PLG   L P
Sbjct: 1510 LRRIQPPLGFGKLCP 1524



 Score =  247 bits (631), Expect = 8e-65
 Identities = 188/698 (26%), Positives = 332/698 (47%), Gaps = 98/698 (14%)

Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
            R  C  I+  K F+ ++L+ IF NC+ +A+  P   D  +A    L    Y+F  +F  E
Sbjct: 114  RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173

Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
              +KV+A G  F   AYLR+ WN+LD ++V++ +   ++   + + G   LG       +
Sbjct: 174  AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233

Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
            + LR  R LRPLR++S    L++V+ +++ ++ P+ +I ++     II+ I+G++LF GK
Sbjct: 234  KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293

Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
                C  +    D     + S CA  +               W   K+   NFDN   A+
Sbjct: 294  MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353

Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
            +++F   + +GW D++Y   DAVG D         W  +YF++ ++I +FFVLN+ +GV+
Sbjct: 354  LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404

Query: 1514 VENFHKCRQH-------QEEEEARRREEKRLRRL-------------------EKKRRNL 1547
               F K R+        Q+  E ++ EE     L                   E+K RN+
Sbjct: 405  SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464

Query: 1548 MLD---------------DVIASGSSASAA---SEAQCKPYYSDYSRF-RLLVHHLCTSH 1588
             +                D+      A  A   S+++   Y+  ++RF R        S+
Sbjct: 465  SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
                 +  ++ LN +T+A EHY QP  L E     N     +F  E + K+ + G + +F
Sbjct: 525  VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
               +N+ D  +V   I+   L E ++     ++P  I ++R +R+ R+ K+ +    +  
Sbjct: 585  VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1767
            L+ +++ ++  + +L LL  L   IF+ LG++LF G    DE        R +TF NF  
Sbjct: 640  LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694

Query: 1768 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1827
            + LT+F++ TG++WN +M D +      S  +  ++  IYF+   +   ++L+NV +A+ 
Sbjct: 695  SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752

Query: 1828 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            + +L   ES   A++E E E E +   +T SP+    L
Sbjct: 753  VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790



 Score =  148 bits (374), Expect = 5e-35
 Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C+  V    FE I +L I  NCV L ++ P  +   ++     L+  +      F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172

Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
           E  +K++A G+ F    YL + WN LDF IV+ G+    L+    +              
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232

Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             A+R  RVLRPLR ++ VPS+++++  ++  +  L ++ LL  FV  I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292

Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
            +   C+  E                        I   P E+    C        + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323

Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
             C                   Q  T C  G   P  G  NFDN  +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
           W D++Y+V DA    + +IYF+ LII+GSFF++NL L V++ +FS+ +++     + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 410 REQR 413
           RE++
Sbjct: 425 REKQ 428



 Score =  147 bits (370), Expect = 2e-34
 Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)

Query: 674  GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
            G  E +  +  MP S++E+V   T++    D+   +   +  L      S    +WR   
Sbjct: 455  GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510

Query: 732  -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
              C    R  V S  F   ++  + +NTL++  E++ QP  LT   + +N    +LF  E
Sbjct: 511  RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570

Query: 790  MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
            MLLK+   G   Y  + +N FD  +V   + E +  +       G+SVLR  RL+R+ K+
Sbjct: 571  MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630

Query: 845  VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
             R+  +L   +  L+ ++ ++A+  +LL LFI IFS+LGM LFG KF  +   +    R 
Sbjct: 631  TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
             FD+   +++TVFQILT EDWN V+Y+G+ +            +YFI L   GNY+L N+
Sbjct: 688  TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747

Query: 959  LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
             +AI V+          ++ E        + + +RKK     S    PE ++ L+  P +
Sbjct: 748  FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796

Query: 1018 IHTAATPMSLPKSTSTG 1034
              +    + L   T+ G
Sbjct: 797  GESKEEKIELKSITADG 813



 Score =  110 bits (276), Expect = 1e-23
 Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)

Query: 49   EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
            + +P P  +   FF  S ++R R  C R V +  F  + +  ILL+ ++L    P +   
Sbjct: 870  KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926

Query: 109  CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
              S R  IL   D    + F +E+++KM A G F  K  +  + +N LD  +V   ++ +
Sbjct: 927  --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984

Query: 168  SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
             +    ++   + R +RVLRPLRAINR   ++ +V  +   +  +GN++++   + F+F 
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044

Query: 227  IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
             +GVQL+ G L    +   + S     + +  Y T  + E      QPR           
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089

Query: 287  TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
                                        +W          E++ F    +FDN+  A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107

Query: 347  IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
            +F V T EGW +++Y  +D+H+      YN+     I+FI+ II+ +FFM+N+ +  +  
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167

Query: 397  QFSETKQRE 405
             F E  ++E
Sbjct: 1168 TFQEQGEQE 1176



 Score =  108 bits (271), Expect = 5e-23
 Identities = 70/256 (27%), Positives = 132/256 (51%), Gaps = 29/256 (11%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            +V+S YF   + + IL+NT+ + ++++ Q      A+ I N++FT LF +EM+LKL+ + 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIV------GQQGGGLSV--LRTFRLMRVLKLVRFLPA 850
            P  Y  + +N FD +IVV S+ +I        ++   +S+   R FR+MR++KL+     
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L   +K+   +    +L+++  FI++++GM +FG K A   D   +    NF +  
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTEINRNNNFQTFP 1392

Query: 911  WAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFG 951
             A++ +F+  T E W  ++   M                      SS+A  YFI+     
Sbjct: 1393 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLC 1452

Query: 952  NYVLFNLLVAILVEGF 967
             +++ NL VA++++ F
Sbjct: 1453 AFLIINLFVAVIMDNF 1468



 Score =  105 bits (261), Expect = 7e-22
 Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)

Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
           IV+ K F   I++ I  N +++ I Y   PE+ +NA    LE    +F  +F +E  LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178

Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
           + YG    P  Y++N +N+ D +IVV+ ++  +             G +G G  V  LR 
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238

Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
           FR++R L+LV  +P+LQ  L  ++K M  +    +L++  I I++I+G+ LF  K     
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298

Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
                      + D  P                             NFD+  +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358

Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
            +T E W  VLY    A    W  +YF+ L+  G++ + NL++ +L   F  E +  K+ 
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418

Query: 978 SE 979
            +
Sbjct: 419 GD 420



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)

Query: 595  TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
            TS   E  +EK   ++A ++ P     L   P    S  + +E +S    G    + KI+
Sbjct: 763  TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822

Query: 652  SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
               L+ +      D  PY      GE +  + EMP              +   L + H +
Sbjct: 823  MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868

Query: 712  RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
             +    P+A    + +    +RL C    +IV+   F   I+  IL++++S+  E   Q 
Sbjct: 869  EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925

Query: 769  EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
                N  L  ++ VFTS+F LE++LK+  YG F     + +N +NI D ++V +S+    
Sbjct: 926  TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984

Query: 824  GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
            G Q   ++V++  R++RVL+ +R       L  + + + V ++T+ N+     LL    F
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041

Query: 878  IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
            +F+ +G+ LF                 CK  + + +DG+              + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101

Query: 910  LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
            L A++ +F + T E W ++LY  + S +             +++FI  +    + + N+ 
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161

Query: 960  VAILVEGFQAEGDANKSESEPD 981
            V  ++  FQ +G+      E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 47/172 (27%), Positives = 83/172 (48%), Gaps = 20/172 (11%)

Query: 78   VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
            V + +FE +  ++ILLN + L M           Q C    A +     F   F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268

Query: 135  KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN-------VSFSAVRTVRVLRP 187
            K++A   F  K Y  D WN  D  IV+  +++ ++   N       +S +  R  RV+R 
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325

Query: 188  LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
            ++ ++R   +R L+   + +   L  V LL   +FFI+ ++G+Q++  +  N
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C   V +  F  + + ++ LN +T+      E     +    +    +  + A F  
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569

Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
           EM++KM +LG+   + Y    +NR D F+V  G+LE  L     +  +  S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626

Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             +      S+  LV  LL+++  + ++LLL F    IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)

Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
           FDN   + + +FQ++T E W  +MY  + A+   +F      IYFI+L I G++ ++N+ 
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748

Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
           L +     ++ +   S    E+  +     +  AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783


>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 12 [Homo sapiens]
          Length = 2146

 Score =  329 bits (843), Expect = 2e-89
 Identities = 228/795 (28%), Positives = 411/795 (51%), Gaps = 78/795 (9%)

Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
            ++EEE  E ++ +   S  + +  +E+ A       + +++  +  TA G    +   + 
Sbjct: 767  KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823

Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
            +    +    ++  P+ P   G++ ++E  +  G R R      L    +     SA+ I
Sbjct: 824  DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882

Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
            F   +RFRL CHRI+   +F +++L  I L+ I++A E P +   S     L  ++Y+FT
Sbjct: 883  FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941

Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
            ++F  E+ +K+ A G    + ++ R+ +N+LD L+V +S+I   +       +  + +++
Sbjct: 942  SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995

Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
            +LR+LR LRPLR I+RA+GLK VV+ +  +++ IGNIV++      +F  +GVQLFKGK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
            + C     +         IT K    +        W   K++FDN+  A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115

Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
            GW +++Y  +D+   D+ PI N+   + ++FI +++I+AFF++N+FVG V+  F    Q 
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171

Query: 1524 QEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHH 1583
            Q E+E +  E      L+K +R  +             A +A+    Y   ++ +  V +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCV-----------EYALKARPLRRYIPKNQHQYKVWY 1214

Query: 1584 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1643
            +  S Y +  +  +I LN + +AM+HY Q  +   A+ I N +FT +F +E + KL+AF 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 1644 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1703
             + +F D WN  D  IV+ SI+ I +   EVN +   +   I   R+ R+ R++KLL   
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEENSRISITFFRLFRVMRLVKLLSRG 1332

Query: 1704 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1763
             G+R LL T +++   +  + LL ++LFFI+A +G+++FG +  ++T     + R+  F+
Sbjct: 1333 EGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQ 1389

Query: 1764 NFGMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFV 1812
             F  A L LFR +TG+ W  IM   +  + C  ES   N+           +  YF+SF 
Sbjct: 1390 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFY 1449

Query: 1813 LTAQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTL 1855
            +   F+++N+ +AV+M                HL+E  +  A+ + E +  ++ L++ TL
Sbjct: 1450 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 1509

Query: 1856 SPQPHSPLGSPFLWP 1870
              +   PLG   L P
Sbjct: 1510 LRRIQPPLGFGKLCP 1524



 Score =  247 bits (631), Expect = 8e-65
 Identities = 188/698 (26%), Positives = 332/698 (47%), Gaps = 98/698 (14%)

Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
            R  C  I+  K F+ ++L+ IF NC+ +A+  P   D  +A    L    Y+F  +F  E
Sbjct: 114  RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173

Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
              +KV+A G  F   AYLR+ WN+LD ++V++ +   ++   + + G   LG       +
Sbjct: 174  AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233

Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
            + LR  R LRPLR++S    L++V+ +++ ++ P+ +I ++     II+ I+G++LF GK
Sbjct: 234  KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293

Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
                C  +    D     + S CA  +               W   K+   NFDN   A+
Sbjct: 294  MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353

Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
            +++F   + +GW D++Y   DAVG D         W  +YF++ ++I +FFVLN+ +GV+
Sbjct: 354  LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404

Query: 1514 VENFHKCRQH-------QEEEEARRREEKRLRRL-------------------EKKRRNL 1547
               F K R+        Q+  E ++ EE     L                   E+K RN+
Sbjct: 405  SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464

Query: 1548 MLD---------------DVIASGSSASAA---SEAQCKPYYSDYSRF-RLLVHHLCTSH 1588
             +                D+      A  A   S+++   Y+  ++RF R        S+
Sbjct: 465  SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
                 +  ++ LN +T+A EHY QP  L E     N     +F  E + K+ + G + +F
Sbjct: 525  VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
               +N+ D  +V   I+   L E ++     ++P  I ++R +R+ R+ K+ +    +  
Sbjct: 585  VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1767
            L+ +++ ++  + +L LL  L   IF+ LG++LF G    DE        R +TF NF  
Sbjct: 640  LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694

Query: 1768 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1827
            + LT+F++ TG++WN +M D +      S  +  ++  IYF+   +   ++L+NV +A+ 
Sbjct: 695  SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752

Query: 1828 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            + +L   ES   A++E E E E +   +T SP+    L
Sbjct: 753  VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790



 Score =  148 bits (374), Expect = 5e-35
 Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C+  V    FE I +L I  NCV L ++ P  +   ++     L+  +      F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172

Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
           E  +K++A G+ F    YL + WN LDF IV+ G+    L+    +              
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232

Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             A+R  RVLRPLR ++ VPS+++++  ++  +  L ++ LL  FV  I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292

Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
            +   C+  E                        I   P E+    C        + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323

Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
             C                   Q  T C  G   P  G  NFDN  +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
           W D++Y+V DA    + +IYF+ LII+GSFF++NL L V++ +FS+ +++     + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 410 REQR 413
           RE++
Sbjct: 425 REKQ 428



 Score =  147 bits (370), Expect = 2e-34
 Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)

Query: 674  GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
            G  E +  +  MP S++E+V   T++    D+   +   +  L      S    +WR   
Sbjct: 455  GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510

Query: 732  -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
              C    R  V S  F   ++  + +NTL++  E++ QP  LT   + +N    +LF  E
Sbjct: 511  RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570

Query: 790  MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
            MLLK+   G   Y  + +N FD  +V   + E +  +       G+SVLR  RL+R+ K+
Sbjct: 571  MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630

Query: 845  VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
             R+  +L   +  L+ ++ ++A+  +LL LFI IFS+LGM LFG KF  +   +    R 
Sbjct: 631  TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
             FD+   +++TVFQILT EDWN V+Y+G+ +            +YFI L   GNY+L N+
Sbjct: 688  TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747

Query: 959  LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
             +AI V+          ++ E        + + +RKK     S    PE ++ L+  P +
Sbjct: 748  FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796

Query: 1018 IHTAATPMSLPKSTSTG 1034
              +    + L   T+ G
Sbjct: 797  GESKEEKIELKSITADG 813



 Score =  110 bits (276), Expect = 1e-23
 Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)

Query: 49   EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
            + +P P  +   FF  S ++R R  C R V +  F  + +  ILL+ ++L    P +   
Sbjct: 870  KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926

Query: 109  CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
              S R  IL   D    + F +E+++KM A G F  K  +  + +N LD  +V   ++ +
Sbjct: 927  --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984

Query: 168  SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
             +    ++   + R +RVLRPLRAINR   ++ +V  +   +  +GN++++   + F+F 
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044

Query: 227  IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
             +GVQL+ G L    +   + S     + +  Y T  + E      QPR           
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089

Query: 287  TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
                                        +W          E++ F    +FDN+  A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107

Query: 347  IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
            +F V T EGW +++Y  +D+H+      YN+     I+FI+ II+ +FFM+N+ +  +  
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167

Query: 397  QFSETKQRE 405
             F E  ++E
Sbjct: 1168 TFQEQGEQE 1176



 Score =  108 bits (271), Expect = 5e-23
 Identities = 70/256 (27%), Positives = 132/256 (51%), Gaps = 29/256 (11%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            +V+S YF   + + IL+NT+ + ++++ Q      A+ I N++FT LF +EM+LKL+ + 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIV------GQQGGGLSV--LRTFRLMRVLKLVRFLPA 850
            P  Y  + +N FD +IVV S+ +I        ++   +S+   R FR+MR++KL+     
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L   +K+   +    +L+++  FI++++GM +FG K A   D   +    NF +  
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTEINRNNNFQTFP 1392

Query: 911  WAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFG 951
             A++ +F+  T E W  ++   M                      SS+A  YFI+     
Sbjct: 1393 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLC 1452

Query: 952  NYVLFNLLVAILVEGF 967
             +++ NL VA++++ F
Sbjct: 1453 AFLIINLFVAVIMDNF 1468



 Score =  105 bits (261), Expect = 7e-22
 Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)

Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
           IV+ K F   I++ I  N +++ I Y   PE+ +NA    LE    +F  +F +E  LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178

Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
           + YG    P  Y++N +N+ D +IVV+ ++  +             G +G G  V  LR 
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238

Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
           FR++R L+LV  +P+LQ  L  ++K M  +    +L++  I I++I+G+ LF  K     
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298

Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
                      + D  P                             NFD+  +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358

Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
            +T E W  VLY    A    W  +YF+ L+  G++ + NL++ +L   F  E +  K+ 
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418

Query: 978 SE 979
            +
Sbjct: 419 GD 420



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)

Query: 595  TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
            TS   E  +EK   ++A ++ P     L   P    S  + +E +S    G    + KI+
Sbjct: 763  TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822

Query: 652  SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
               L+ +      D  PY      GE +  + EMP              +   L + H +
Sbjct: 823  MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868

Query: 712  RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
             +    P+A    + +    +RL C    +IV+   F   I+  IL++++S+  E   Q 
Sbjct: 869  EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925

Query: 769  EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
                N  L  ++ VFTS+F LE++LK+  YG F     + +N +NI D ++V +S+    
Sbjct: 926  TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984

Query: 824  GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
            G Q   ++V++  R++RVL+ +R       L  + + + V ++T+ N+     LL    F
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041

Query: 878  IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
            +F+ +G+ LF                 CK  + + +DG+              + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101

Query: 910  LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
            L A++ +F + T E W ++LY  + S +             +++FI  +    + + N+ 
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161

Query: 960  VAILVEGFQAEGDANKSESEPD 981
            V  ++  FQ +G+      E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 47/172 (27%), Positives = 83/172 (48%), Gaps = 20/172 (11%)

Query: 78   VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
            V + +FE +  ++ILLN + L M           Q C    A +     F   F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268

Query: 135  KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN-------VSFSAVRTVRVLRP 187
            K++A   F  K Y  D WN  D  IV+  +++ ++   N       +S +  R  RV+R 
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325

Query: 188  LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
            ++ ++R   +R L+   + +   L  V LL   +FFI+ ++G+Q++  +  N
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C   V +  F  + + ++ LN +T+      E     +    +    +  + A F  
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569

Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
           EM++KM +LG+   + Y    +NR D F+V  G+LE  L     +  +  S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626

Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             +      S+  LV  LL+++  + ++LLL F    IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)

Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
           FDN   + + +FQ++T E W  +MY  + A+   +F      IYFI+L I G++ ++N+ 
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748

Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
           L +     ++ +   S    E+  +     +  AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783


>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 4 [Homo sapiens]
          Length = 2173

 Score =  328 bits (842), Expect = 3e-89
 Identities = 227/804 (28%), Positives = 412/804 (51%), Gaps = 85/804 (10%)

Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
            ++EEE  E ++ +   S  + +  +E+ A       + +++  +  TA G    +   + 
Sbjct: 767  KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823

Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
            +    +    ++  P+ P   G++ ++E  +  G R R      L    +     SA+ I
Sbjct: 824  DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882

Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
            F   +RFRL CHRI+   +F +++L  I L+ I++A E P +   S     L  ++Y+FT
Sbjct: 883  FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941

Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
            ++F  E+ +K+ A G    + ++ R+ +N+LD L+V +S+I   +       +  + +++
Sbjct: 942  SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995

Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
            +LR+LR LRPLR I+RA+GLK VV+ +  +++ IGNIV++      +F  +GVQLFKGK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
            + C     +         IT K    +        W   K++FDN+  A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115

Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
            GW +++Y  +D+   D+ PI N+   + ++FI +++I+AFF++N+FVG V+  F    Q 
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171

Query: 1524 QEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHH 1583
            Q E+E +  E      L+K +R  +             A +A+    Y   ++ +  V +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCV-----------EYALKARPLRRYIPKNQHQYKVWY 1214

Query: 1584 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1643
            +  S Y +  +  +I LN + +AM+HY Q  +   A+ I N +FT +F +E + KL+AF 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 1644 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI---------IRIMRVLRIA 1694
             + +F D WN  D  IV+ SI+ I + E+        +P++         I   R+ R+ 
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334

Query: 1695 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCE 1754
            R++KLL    G+R LL T +++   +  + LL ++LFFI+A +G+++FG +  ++T    
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---T 1391

Query: 1755 GLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------I 1803
             + R+  F+ F  A L LFR +TG+ W  IM   +  + C  ES   N+           
Sbjct: 1392 EINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1451

Query: 1804 SPIYFVSFVLTAQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAE 1847
            +  YF+SF +   F+++N+ +AV+M                HL+E  +  A+ + E +  
Sbjct: 1452 AVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGR 1511

Query: 1848 LE-LEMKTLSPQPHSPLGSPFLWP 1870
            ++ L++ TL  +   PLG   L P
Sbjct: 1512 IKHLDVVTLLRRIQPPLGFGKLCP 1535



 Score =  247 bits (631), Expect = 8e-65
 Identities = 188/698 (26%), Positives = 332/698 (47%), Gaps = 98/698 (14%)

Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
            R  C  I+  K F+ ++L+ IF NC+ +A+  P   D  +A    L    Y+F  +F  E
Sbjct: 114  RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173

Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
              +KV+A G  F   AYLR+ WN+LD ++V++ +   ++   + + G   LG       +
Sbjct: 174  AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233

Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
            + LR  R LRPLR++S    L++V+ +++ ++ P+ +I ++     II+ I+G++LF GK
Sbjct: 234  KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293

Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
                C  +    D     + S CA  +               W   K+   NFDN   A+
Sbjct: 294  MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353

Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
            +++F   + +GW D++Y   DAVG D         W  +YF++ ++I +FFVLN+ +GV+
Sbjct: 354  LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404

Query: 1514 VENFHKCRQH-------QEEEEARRREEKRLRRL-------------------EKKRRNL 1547
               F K R+        Q+  E ++ EE     L                   E+K RN+
Sbjct: 405  SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464

Query: 1548 MLD---------------DVIASGSSASAA---SEAQCKPYYSDYSRF-RLLVHHLCTSH 1588
             +                D+      A  A   S+++   Y+  ++RF R        S+
Sbjct: 465  SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
                 +  ++ LN +T+A EHY QP  L E     N     +F  E + K+ + G + +F
Sbjct: 525  VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
               +N+ D  +V   I+   L E ++     ++P  I ++R +R+ R+ K+ +    +  
Sbjct: 585  VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1767
            L+ +++ ++  + +L LL  L   IF+ LG++LF G    DE        R +TF NF  
Sbjct: 640  LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694

Query: 1768 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1827
            + LT+F++ TG++WN +M D +      S  +  ++  IYF+   +   ++L+NV +A+ 
Sbjct: 695  SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752

Query: 1828 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            + +L   ES   A++E E E E +   +T SP+    L
Sbjct: 753  VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790



 Score =  148 bits (374), Expect = 5e-35
 Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C+  V    FE I +L I  NCV L ++ P  +   ++     L+  +      F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172

Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
           E  +K++A G+ F    YL + WN LDF IV+ G+    L+    +              
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232

Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             A+R  RVLRPLR ++ VPS+++++  ++  +  L ++ LL  FV  I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292

Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
            +   C+  E                        I   P E+    C        + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323

Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
             C                   Q  T C  G   P  G  NFDN  +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
           W D++Y+V DA    + +IYF+ LII+GSFF++NL L V++ +FS+ +++     + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 410 REQR 413
           RE++
Sbjct: 425 REKQ 428



 Score =  147 bits (370), Expect = 2e-34
 Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)

Query: 674  GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
            G  E +  +  MP S++E+V   T++    D+   +   +  L      S    +WR   
Sbjct: 455  GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510

Query: 732  -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
              C    R  V S  F   ++  + +NTL++  E++ QP  LT   + +N    +LF  E
Sbjct: 511  RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570

Query: 790  MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
            MLLK+   G   Y  + +N FD  +V   + E +  +       G+SVLR  RL+R+ K+
Sbjct: 571  MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630

Query: 845  VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
             R+  +L   +  L+ ++ ++A+  +LL LFI IFS+LGM LFG KF  +   +    R 
Sbjct: 631  TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
             FD+   +++TVFQILT EDWN V+Y+G+ +            +YFI L   GNY+L N+
Sbjct: 688  TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747

Query: 959  LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
             +AI V+          ++ E        + + +RKK     S    PE ++ L+  P +
Sbjct: 748  FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796

Query: 1018 IHTAATPMSLPKSTSTG 1034
              +    + L   T+ G
Sbjct: 797  GESKEEKIELKSITADG 813



 Score =  110 bits (276), Expect = 1e-23
 Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)

Query: 49   EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
            + +P P  +   FF  S ++R R  C R V +  F  + +  ILL+ ++L    P +   
Sbjct: 870  KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926

Query: 109  CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
              S R  IL   D    + F +E+++KM A G F  K  +  + +N LD  +V   ++ +
Sbjct: 927  --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984

Query: 168  SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
             +    ++   + R +RVLRPLRAINR   ++ +V  +   +  +GN++++   + F+F 
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044

Query: 227  IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
             +GVQL+ G L    +   + S     + +  Y T  + E      QPR           
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089

Query: 287  TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
                                        +W          E++ F    +FDN+  A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107

Query: 347  IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
            +F V T EGW +++Y  +D+H+      YN+     I+FI+ II+ +FFM+N+ +  +  
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167

Query: 397  QFSETKQRE 405
             F E  ++E
Sbjct: 1168 TFQEQGEQE 1176



 Score =  105 bits (261), Expect = 7e-22
 Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)

Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
           IV+ K F   I++ I  N +++ I Y   PE+ +NA    LE    +F  +F +E  LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178

Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
           + YG    P  Y++N +N+ D +IVV+ ++  +             G +G G  V  LR 
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238

Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
           FR++R L+LV  +P+LQ  L  ++K M  +    +L++  I I++I+G+ LF  K     
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298

Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
                      + D  P                             NFD+  +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358

Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
            +T E W  VLY    A    W  +YF+ L+  G++ + NL++ +L   F  E +  K+ 
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418

Query: 978 SE 979
            +
Sbjct: 419 GD 420



 Score =  104 bits (260), Expect = 9e-22
 Identities = 70/267 (26%), Positives = 132/267 (49%), Gaps = 40/267 (14%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            +V+S YF   + + IL+NT+ + ++++ Q      A+ I N++FT LF +EM+LKL+ + 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIV-----------------GQQGGGLSV--LRTFRLM 839
            P  Y  + +N FD +IVV S+ +I                   ++   +S+   R FR+M
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334

Query: 840  RVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT 899
            R++KL+     ++  L   +K+   +    +L+++  FI++++GM +FG K A   D   
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTE 1392

Query: 900  LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWA 940
            +    NF +   A++ +F+  T E W  ++   M                      SS+A
Sbjct: 1393 INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA 1452

Query: 941  ALYFIALMTFGNYVLFNLLVAILVEGF 967
              YFI+      +++ NL VA++++ F
Sbjct: 1453 VFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)

Query: 595  TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
            TS   E  +EK   ++A ++ P     L   P    S  + +E +S    G    + KI+
Sbjct: 763  TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822

Query: 652  SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
               L+ +      D  PY      GE +  + EMP              +   L + H +
Sbjct: 823  MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868

Query: 712  RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
             +    P+A    + +    +RL C    +IV+   F   I+  IL++++S+  E   Q 
Sbjct: 869  EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925

Query: 769  EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
                N  L  ++ VFTS+F LE++LK+  YG F     + +N +NI D ++V +S+    
Sbjct: 926  TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984

Query: 824  GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
            G Q   ++V++  R++RVL+ +R       L  + + + V ++T+ N+     LL    F
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041

Query: 878  IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
            +F+ +G+ LF                 CK  + + +DG+              + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101

Query: 910  LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
            L A++ +F + T E W ++LY  + S +             +++FI  +    + + N+ 
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161

Query: 960  VAILVEGFQAEGDANKSESEPD 981
            V  ++  FQ +G+      E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C   V +  F  + + ++ LN +T+      E     +    +    +  + A F  
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569

Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
           EM++KM +LG+   + Y    +NR D F+V  G+LE  L     +  +  S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626

Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             +      S+  LV  LL+++  + ++LLL F    IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 47/183 (25%), Positives = 83/183 (45%), Gaps = 31/183 (16%)

Query: 78   VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
            V + +FE +  ++ILLN + L M           Q C    A +     F   F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268

Query: 135  KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN------------------VSF 176
            K++A   F  K Y  D WN  D  IV+  +++ ++   N                  +S 
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISI 1325

Query: 177  SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  R  RV+R ++ ++R   +R L+   + +   L  V LL   +FFI+ ++G+Q++  +
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385

Query: 237  LRN 239
              N
Sbjct: 1386 ALN 1388



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)

Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
           FDN   + + +FQ++T E W  +MY  + A+   +F      IYFI+L I G++ ++N+ 
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748

Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
           L +     ++ +   S    E+  +     +  AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783


>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 17 [Homo sapiens]
          Length = 2138

 Score =  328 bits (842), Expect = 3e-89
 Identities = 227/804 (28%), Positives = 412/804 (51%), Gaps = 85/804 (10%)

Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
            ++EEE  E ++ +   S  + +  +E+ A       + +++  +  TA G    +   + 
Sbjct: 767  KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823

Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
            +    +    ++  P+ P   G++ ++E  +  G R R      L    +     SA+ I
Sbjct: 824  DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882

Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
            F   +RFRL CHRI+   +F +++L  I L+ I++A E P +   S     L  ++Y+FT
Sbjct: 883  FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941

Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
            ++F  E+ +K+ A G    + ++ R+ +N+LD L+V +S+I   +       +  + +++
Sbjct: 942  SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995

Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
            +LR+LR LRPLR I+RA+GLK VV+ +  +++ IGNIV++      +F  +GVQLFKGK 
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
            + C     +         IT K    +        W   K++FDN+  A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115

Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
            GW +++Y  +D+   D+ PI N+   + ++FI +++I+AFF++N+FVG V+  F    Q 
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171

Query: 1524 QEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHH 1583
            Q E+E +  E      L+K +R  +             A +A+    Y   ++ +  V +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCV-----------EYALKARPLRRYIPKNQHQYKVWY 1214

Query: 1584 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1643
            +  S Y +  +  +I LN + +AM+HY Q  +   A+ I N +FT +F +E + KL+AF 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 1644 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI---------IRIMRVLRIA 1694
             + +F D WN  D  IV+ SI+ I + E+        +P++         I   R+ R+ 
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334

Query: 1695 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCE 1754
            R++KLL    G+R LL T +++   +  + LL ++LFFI+A +G+++FG +  ++T    
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---T 1391

Query: 1755 GLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------I 1803
             + R+  F+ F  A L LFR +TG+ W  IM   +  + C  ES   N+           
Sbjct: 1392 EINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1451

Query: 1804 SPIYFVSFVLTAQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAE 1847
            +  YF+SF +   F+++N+ +AV+M                HL+E  +  A+ + E +  
Sbjct: 1452 AVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGR 1511

Query: 1848 LE-LEMKTLSPQPHSPLGSPFLWP 1870
            ++ L++ TL  +   PLG   L P
Sbjct: 1512 IKHLDVVTLLRRIQPPLGFGKLCP 1535



 Score =  247 bits (631), Expect = 8e-65
 Identities = 188/698 (26%), Positives = 332/698 (47%), Gaps = 98/698 (14%)

Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
            R  C  I+  K F+ ++L+ IF NC+ +A+  P   D  +A    L    Y+F  +F  E
Sbjct: 114  RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173

Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
              +KV+A G  F   AYLR+ WN+LD ++V++ +   ++   + + G   LG       +
Sbjct: 174  AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233

Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
            + LR  R LRPLR++S    L++V+ +++ ++ P+ +I ++     II+ I+G++LF GK
Sbjct: 234  KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293

Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
                C  +    D     + S CA  +               W   K+   NFDN   A+
Sbjct: 294  MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353

Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
            +++F   + +GW D++Y   DAVG D         W  +YF++ ++I +FFVLN+ +GV+
Sbjct: 354  LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404

Query: 1514 VENFHKCRQH-------QEEEEARRREEKRLRRL-------------------EKKRRNL 1547
               F K R+        Q+  E ++ EE     L                   E+K RN+
Sbjct: 405  SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464

Query: 1548 MLD---------------DVIASGSSASAA---SEAQCKPYYSDYSRF-RLLVHHLCTSH 1588
             +                D+      A  A   S+++   Y+  ++RF R        S+
Sbjct: 465  SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524

Query: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648
                 +  ++ LN +T+A EHY QP  L E     N     +F  E + K+ + G + +F
Sbjct: 525  VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584

Query: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708
               +N+ D  +V   I+   L E ++     ++P  I ++R +R+ R+ K+ +    +  
Sbjct: 585  VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639

Query: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1767
            L+ +++ ++  + +L LL  L   IF+ LG++LF G    DE        R +TF NF  
Sbjct: 640  LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694

Query: 1768 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1827
            + LT+F++ TG++WN +M D +      S  +  ++  IYF+   +   ++L+NV +A+ 
Sbjct: 695  SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752

Query: 1828 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863
            + +L   ES   A++E E E E +   +T SP+    L
Sbjct: 753  VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790



 Score =  148 bits (374), Expect = 5e-35
 Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C+  V    FE I +L I  NCV L ++ P  +   ++     L+  +      F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172

Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
           E  +K++A G+ F    YL + WN LDF IV+ G+    L+    +              
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232

Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             A+R  RVLRPLR ++ VPS+++++  ++  +  L ++ LL  FV  I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292

Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
            +   C+  E                        I   P E+    C        + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323

Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
             C                   Q  T C  G   P  G  NFDN  +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
           W D++Y+V DA    + +IYF+ LII+GSFF++NL L V++ +FS+ +++     + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 410 REQR 413
           RE++
Sbjct: 425 REKQ 428



 Score =  147 bits (370), Expect = 2e-34
 Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)

Query: 674  GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
            G  E +  +  MP S++E+V   T++    D+   +   +  L      S    +WR   
Sbjct: 455  GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510

Query: 732  -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
              C    R  V S  F   ++  + +NTL++  E++ QP  LT   + +N    +LF  E
Sbjct: 511  RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570

Query: 790  MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
            MLLK+   G   Y  + +N FD  +V   + E +  +       G+SVLR  RL+R+ K+
Sbjct: 571  MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630

Query: 845  VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
             R+  +L   +  L+ ++ ++A+  +LL LFI IFS+LGM LFG KF  +   +    R 
Sbjct: 631  TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
             FD+   +++TVFQILT EDWN V+Y+G+ +            +YFI L   GNY+L N+
Sbjct: 688  TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747

Query: 959  LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
             +AI V+          ++ E        + + +RKK     S    PE ++ L+  P +
Sbjct: 748  FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796

Query: 1018 IHTAATPMSLPKSTSTG 1034
              +    + L   T+ G
Sbjct: 797  GESKEEKIELKSITADG 813



 Score =  110 bits (276), Expect = 1e-23
 Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)

Query: 49   EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
            + +P P  +   FF  S ++R R  C R V +  F  + +  ILL+ ++L    P +   
Sbjct: 870  KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926

Query: 109  CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
              S R  IL   D    + F +E+++KM A G F  K  +  + +N LD  +V   ++ +
Sbjct: 927  --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984

Query: 168  SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
             +    ++   + R +RVLRPLRAINR   ++ +V  +   +  +GN++++   + F+F 
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044

Query: 227  IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
             +GVQL+ G L    +   + S     + +  Y T  + E      QPR           
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089

Query: 287  TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
                                        +W          E++ F    +FDN+  A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107

Query: 347  IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
            +F V T EGW +++Y  +D+H+      YN+     I+FI+ II+ +FFM+N+ +  +  
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167

Query: 397  QFSETKQRE 405
             F E  ++E
Sbjct: 1168 TFQEQGEQE 1176



 Score =  105 bits (261), Expect = 7e-22
 Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)

Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
           IV+ K F   I++ I  N +++ I Y   PE+ +NA    LE    +F  +F +E  LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178

Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
           + YG    P  Y++N +N+ D +IVV+ ++  +             G +G G  V  LR 
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238

Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
           FR++R L+LV  +P+LQ  L  ++K M  +    +L++  I I++I+G+ LF  K     
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298

Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
                      + D  P                             NFD+  +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358

Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
            +T E W  VLY    A    W  +YF+ L+  G++ + NL++ +L   F  E +  K+ 
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418

Query: 978 SE 979
            +
Sbjct: 419 GD 420



 Score =  104 bits (260), Expect = 9e-22
 Identities = 70/267 (26%), Positives = 132/267 (49%), Gaps = 40/267 (14%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            +V+S YF   + + IL+NT+ + ++++ Q      A+ I N++FT LF +EM+LKL+ + 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIV-----------------GQQGGGLSV--LRTFRLM 839
            P  Y  + +N FD +IVV S+ +I                   ++   +S+   R FR+M
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334

Query: 840  RVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT 899
            R++KL+     ++  L   +K+   +    +L+++  FI++++GM +FG K A   D   
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTE 1392

Query: 900  LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWA 940
            +    NF +   A++ +F+  T E W  ++   M                      SS+A
Sbjct: 1393 INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA 1452

Query: 941  ALYFIALMTFGNYVLFNLLVAILVEGF 967
              YFI+      +++ NL VA++++ F
Sbjct: 1453 VFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)

Query: 595  TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
            TS   E  +EK   ++A ++ P     L   P    S  + +E +S    G    + KI+
Sbjct: 763  TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822

Query: 652  SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
               L+ +      D  PY      GE +  + EMP              +   L + H +
Sbjct: 823  MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868

Query: 712  RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
             +    P+A    + +    +RL C    +IV+   F   I+  IL++++S+  E   Q 
Sbjct: 869  EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925

Query: 769  EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
                N  L  ++ VFTS+F LE++LK+  YG F     + +N +NI D ++V +S+    
Sbjct: 926  TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984

Query: 824  GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
            G Q   ++V++  R++RVL+ +R       L  + + + V ++T+ N+     LL    F
Sbjct: 985  GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041

Query: 878  IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
            +F+ +G+ LF                 CK  + + +DG+              + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101

Query: 910  LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
            L A++ +F + T E W ++LY  + S +             +++FI  +    + + N+ 
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161

Query: 960  VAILVEGFQAEGDANKSESEPD 981
            V  ++  FQ +G+      E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R  C   V +  F  + + ++ LN +T+      E     +    +    +  + A F  
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569

Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
           EM++KM +LG+   + Y    +NR D F+V  G+LE  L     +  +  S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626

Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             +      S+  LV  LL+++  + ++LLL F    IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 47/183 (25%), Positives = 83/183 (45%), Gaps = 31/183 (16%)

Query: 78   VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
            V + +FE +  ++ILLN + L M           Q C    A +     F   F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268

Query: 135  KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN------------------VSF 176
            K++A   F  K Y  D WN  D  IV+  +++ ++   N                  +S 
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISI 1325

Query: 177  SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  R  RV+R ++ ++R   +R L+   + +   L  V LL   +FFI+ ++G+Q++  +
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385

Query: 237  LRN 239
              N
Sbjct: 1386 ALN 1388



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)

Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
           FDN   + + +FQ++T E W  +MY  + A+   +F      IYFI+L I G++ ++N+ 
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748

Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
           L +     ++ +   S    E+  +     +  AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,312,229
Number of Sequences: 37866
Number of extensions: 5437364
Number of successful extensions: 41718
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 251
Number of HSP's successfully gapped in prelim test: 640
Number of HSP's that attempted gapping in prelim test: 30277
Number of HSP's gapped (non-prelim): 7152
length of query: 2306
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2188
effective length of database: 13,779,330
effective search space: 30149174040
effective search space used: 30149174040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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