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Search of human proteins with 38505268
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
(2171 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 4389 0.0
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 4107 0.0
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 4094 0.0
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 4086 0.0
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 4086 0.0
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 4084 0.0
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 4073 0.0
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 4073 0.0
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 4071 0.0
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 4065 0.0
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 4051 0.0
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 3815 0.0
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 3795 0.0
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 3782 0.0
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 2306 0.0
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 2303 0.0
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 1461 0.0
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 1461 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 449 e-125
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 449 e-125
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 447 e-125
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 436 e-121
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 425 e-118
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 350 9e-96
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 336 2e-91
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 335 4e-91
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 335 4e-91
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 334 5e-91
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 334 5e-91
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 4389 bits (11384), Expect = 0.0
Identities = 2171/2171 (100%), Positives = 2171/2171 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
Query: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF
Sbjct: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
Query: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL
Sbjct: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
Query: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH
Sbjct: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
Query: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF
Sbjct: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
Query: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG
Sbjct: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
Query: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL 1920
VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL
Sbjct: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL 1920
Query: 1921 PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS 1980
PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS
Sbjct: 1921 PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS 1980
Query: 1981 APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKC 2040
APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKC
Sbjct: 1981 APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKC 2040
Query: 2041 YSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKL 2100
YSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKL
Sbjct: 2041 YSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKL 2100
Query: 2101 SPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLS 2160
SPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLS
Sbjct: 2101 SPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLS 2160
Query: 2161 GLSSDPADLDP 2171
GLSSDPADLDP
Sbjct: 2161 GLSSDPADLDP 2171
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 4107 bits (10651), Expect = 0.0
Identities = 2056/2121 (96%), Positives = 2063/2121 (97%), Gaps = 8/2121 (0%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
Query: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF
Sbjct: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
Query: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL
Sbjct: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
Query: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH
Sbjct: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
Query: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF
Sbjct: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
Query: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG
Sbjct: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
Query: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL 1920
VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL
Sbjct: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL 1920
Query: 1921 PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS 1980
PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS
Sbjct: 1921 PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS 1980
Query: 1981 APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKC 2040
APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE PSP L +
Sbjct: 1981 APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSP-PLARA 2039
Query: 2041 YSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKL 2100
YS QS T R HS +S + P G +P+ G P +L
Sbjct: 2040 YSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTEL 2094
Query: 2101 SPPSITIDPPESQGPRTPPSP 2121
S S + PP G PPSP
Sbjct: 2095 SWISGDLLPP--GGQEEPPSP 2113
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 4094 bits (10617), Expect = 0.0
Identities = 2056/2144 (95%), Positives = 2063/2144 (96%), Gaps = 31/2144 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME
Sbjct: 1561 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1620
Query: 1598 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1657
HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT
Sbjct: 1621 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1680
Query: 1658 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1717
LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM
Sbjct: 1681 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1740
Query: 1718 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1777
LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT
Sbjct: 1741 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1800
Query: 1778 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL 1837
LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL
Sbjct: 1801 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL 1860
Query: 1838 ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPH 1897
ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPH
Sbjct: 1861 ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPH 1920
Query: 1898 PTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHS 1957
PTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHS
Sbjct: 1921 PTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHS 1980
Query: 1958 QPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQ 2017
QPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQ
Sbjct: 1981 QPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQ 2040
Query: 2018 GLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHL 2077
GLGSREDLLAE PSP L + YS QS T R HS +S + P
Sbjct: 2041 GLGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCP 2094
Query: 2078 GTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
G +P+ G P +LS S + PP G PPSP
Sbjct: 2095 GPEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2136
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 4086 bits (10598), Expect = 0.0
Identities = 2050/2132 (96%), Positives = 2058/2132 (96%), Gaps = 19/2132 (0%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-----------SKEK 1549
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR S
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
Query: 1550 QMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1609
+EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
Query: 1610 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1669
KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
Query: 1670 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1729
NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
Query: 1730 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789
LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
Query: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1849
TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
Query: 1850 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTV 1909
SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTV
Sbjct: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTV 1920
Query: 1910 RKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLP 1969
RKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLP
Sbjct: 1921 RKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLP 1980
Query: 1970 KDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEE 2029
KDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE
Sbjct: 1981 KDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEV 2040
Query: 2030 EPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPL 2089
PSP L + YS QS T R HS +S + P G +P+ G P
Sbjct: 2041 SGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCPGPEPNWGKGPPE 2094
Query: 2090 GGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
+LS S + PP G PPSP
Sbjct: 2095 TRSSLELDTELSWISGDLLPP--GGQEEPPSP 2124
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 4086 bits (10596), Expect = 0.0
Identities = 2048/2121 (96%), Positives = 2056/2121 (96%), Gaps = 15/2121 (0%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR +AQCKPYY
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-------KAQCKPYY 1553
Query: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF
Sbjct: 1554 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1613
Query: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL
Sbjct: 1614 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1673
Query: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH
Sbjct: 1674 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1733
Query: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF
Sbjct: 1734 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1793
Query: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG
Sbjct: 1794 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1853
Query: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL 1920
VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL
Sbjct: 1854 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSL 1913
Query: 1921 PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS 1980
PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS
Sbjct: 1914 PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHS 1973
Query: 1981 APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKC 2040
APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE PSP L +
Sbjct: 1974 APTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSP-PLARA 2032
Query: 2041 YSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKL 2100
YS QS T R HS +S + P G +P+ G P +L
Sbjct: 2033 YSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTEL 2087
Query: 2101 SPPSITIDPPESQGPRTPPSP 2121
S S + PP G PPSP
Sbjct: 2088 SWISGDLLPP--GGQEEPPSP 2106
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 4084 bits (10592), Expect = 0.0
Identities = 2056/2169 (94%), Positives = 2063/2169 (95%), Gaps = 56/2169 (2%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
Query: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF
Sbjct: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
Query: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL
Sbjct: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
Query: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH
Sbjct: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
Query: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF
Sbjct: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
Query: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG
Sbjct: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
Query: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPT--------------------------- 1893
VEGPDSPDSPKPGALHPAAHARSASHFSLEHPT
Sbjct: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSLEWELKLMDELA 1920
Query: 1894 ---------------------MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGST 1932
MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGST
Sbjct: 1921 GPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGST 1980
Query: 1933 AEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPP 1992
AEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPP
Sbjct: 1981 AEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPP 2040
Query: 1993 PGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRP 2052
PGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE PSP L + YS QS
Sbjct: 2041 PGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSP-PLARAYSFWGQS----S 2095
Query: 2053 TSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPES 2112
T R HS +S + P G +P+ G P +LS S + PP
Sbjct: 2096 TQAQQHSRSHS-KISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP-- 2152
Query: 2113 QGPRTPPSP 2121
G PPSP
Sbjct: 2153 GGQEEPPSP 2161
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 2051 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2110
Query: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
+ AP P P WG K PP RS L LD +
Sbjct: 2111 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2145
Query: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2146 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2205
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2206 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2265
Query: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2266 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2298
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 4073 bits (10564), Expect = 0.0
Identities = 2050/2155 (95%), Positives = 2058/2155 (95%), Gaps = 42/2155 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1538 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1586
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1587 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1646
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1647 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1706
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1707 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1766
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1767 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1826
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
Query: 1827 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1886
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
Query: 1887 FSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPK 1946
FSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPK
Sbjct: 1921 FSLEHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPK 1980
Query: 1947 AQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQ 2006
AQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQ
Sbjct: 1981 AQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQ 2040
Query: 2007 AAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAV 2066
AAIRTDSLDVQGLGSREDLLAE PSP L + YS QS T R HS +
Sbjct: 2041 AAIRTDSLDVQGLGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KI 2094
Query: 2067 SCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
S + P G +P+ G P +LS S + PP G PPSP
Sbjct: 2095 SKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2147
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 4073 bits (10562), Expect = 0.0
Identities = 2048/2144 (95%), Positives = 2056/2144 (95%), Gaps = 38/2144 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
RRLEKKRR +AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME
Sbjct: 1561 RRLEKKRR-------KAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1613
Query: 1598 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1657
HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT
Sbjct: 1614 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1673
Query: 1658 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1717
LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM
Sbjct: 1674 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1733
Query: 1718 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1777
LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT
Sbjct: 1734 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1793
Query: 1778 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL 1837
LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL
Sbjct: 1794 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL 1853
Query: 1838 ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPH 1897
ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPH
Sbjct: 1854 ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPH 1913
Query: 1898 PTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHS 1957
PTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHS
Sbjct: 1914 PTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHS 1973
Query: 1958 QPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQ 2017
QPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQ
Sbjct: 1974 QPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQ 2033
Query: 2018 GLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHL 2077
GLGSREDLLAE PSP L + YS QS T R HS +S + P
Sbjct: 2034 GLGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCP 2087
Query: 2078 GTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
G +P+ G P +LS S + PP G PPSP
Sbjct: 2088 GPEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2129
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 4071 bits (10558), Expect = 0.0
Identities = 2056/2192 (93%), Positives = 2063/2192 (94%), Gaps = 79/2192 (3%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME
Sbjct: 1561 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1620
Query: 1598 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1657
HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT
Sbjct: 1621 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1680
Query: 1658 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1717
LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM
Sbjct: 1681 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1740
Query: 1718 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1777
LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT
Sbjct: 1741 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1800
Query: 1778 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL 1837
LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL
Sbjct: 1801 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEL 1860
Query: 1838 ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---- 1893
ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT
Sbjct: 1861 ELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQL 1920
Query: 1894 --------------------------------------------MQPHPTELPGPDLLTV 1909
MQPHPTELPGPDLLTV
Sbjct: 1921 FDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTV 1980
Query: 1910 RKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLP 1969
RKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLP
Sbjct: 1981 RKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLP 2040
Query: 1970 KDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEE 2029
KDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE
Sbjct: 2041 KDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEV 2100
Query: 2030 EPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPL 2089
PSP L + YS QS T R HS +S + P G +P+ G P
Sbjct: 2101 SGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCPGPEPNWGKGPPE 2154
Query: 2090 GGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
+LS S + PP G PPSP
Sbjct: 2155 TRSSLELDTELSWISGDLLPP--GGQEEPPSP 2184
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 2074 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2133
Query: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
+ AP P P WG K PP RS L LD +
Sbjct: 2134 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2168
Query: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2169 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2228
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2229 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2288
Query: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2289 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2321
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 4065 bits (10542), Expect = 0.0
Identities = 2050/2177 (94%), Positives = 2058/2177 (94%), Gaps = 64/2177 (2%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-----------SKEK 1549
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR S
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
Query: 1550 QMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1609
+EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
Query: 1610 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1669
KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
Query: 1670 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1729
NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
Query: 1730 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789
LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
Query: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1849
TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
Query: 1850 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT---------------- 1893
SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT
Sbjct: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIV 1920
Query: 1894 -----------------------------MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1924
MQPHPTELPGPDLLTVRKSGVSRTHSLPNDS
Sbjct: 1921 SEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDS 1980
Query: 1925 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 1984
YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW
Sbjct: 1981 YMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2040
Query: 1985 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPPSPRDLKKCYSVE 2044
GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE PSP L + YS
Sbjct: 2041 GTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSP-PLARAYSFW 2099
Query: 2045 AQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS 2104
QS T R HS +S + P G +P+ G P +LS S
Sbjct: 2100 GQS----STQAQQHSRSHS-KISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWIS 2154
Query: 2105 ITIDPPESQGPRTPPSP 2121
+ PP G PPSP
Sbjct: 2155 GDLLPP--GGQEEPPSP 2169
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 2059 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2118
Query: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
+ AP P P WG K PP RS L LD +
Sbjct: 2119 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2153
Query: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2154 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2213
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2214 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2273
Query: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2274 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2306
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 4051 bits (10505), Expect = 0.0
Identities = 2050/2203 (93%), Positives = 2058/2203 (93%), Gaps = 90/2203 (4%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1538 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1586
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1587 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1646
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1647 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1706
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1707 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1766
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1767 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1826
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
Query: 1827 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1886
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
Query: 1887 FSLEHPT------------------------------------------------MQPHP 1898
FSLEHPT MQPHP
Sbjct: 1921 FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQPHP 1980
Query: 1899 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 1958
TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ
Sbjct: 1981 TELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2040
Query: 1959 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2018
PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG
Sbjct: 2041 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQG 2100
Query: 2019 LGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
LGSREDLLAE PSP L + YS QS T R HS +S + P G
Sbjct: 2101 LGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPPAPCPG 2154
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
+P+ G P +LS S + PP G PPSP
Sbjct: 2155 PEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2195
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 2085 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2144
Query: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
+ AP P P WG K PP RS L LD +
Sbjct: 2145 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2179
Query: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2180 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2239
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2240 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2299
Query: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2300 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2332
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 3815 bits (9894), Expect = 0.0
Identities = 1893/1893 (100%), Positives = 1893/1893 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYY 1560
Query: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF
Sbjct: 1561 SDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF 1620
Query: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL
Sbjct: 1621 VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1680
Query: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH
Sbjct: 1681 RIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETH 1740
Query: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF
Sbjct: 1741 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSF 1800
Query: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG
Sbjct: 1801 VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPG 1860
Query: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPT 1893
VEGPDSPDSPKPGALHPAAHARSASHFSLEHPT
Sbjct: 1861 VEGPDSPDSPKPGALHPAAHARSASHFSLEHPT 1893
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 2096 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2155
Query: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
+ AP P P WG K PP RS L LD +
Sbjct: 2156 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2190
Query: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2191 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2250
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2251 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2310
Query: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2311 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2343
Score = 296 bits (757), Expect = 2e-79
Identities = 163/228 (71%), Positives = 170/228 (74%), Gaps = 8/228 (3%)
Query: 1894 MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL 1953
MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL
Sbjct: 1987 MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL 2046
Query: 1954 SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS 2013
SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS
Sbjct: 2047 SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS 2106
Query: 2014 LDVQGLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGS 2073
LDVQGLGSREDLLAE PSP L + YS QS T R HS +S +
Sbjct: 2107 LDVQGLGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPP 2160
Query: 2074 QPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
P G +P+ G P +LS S + PP G PPSP
Sbjct: 2161 APCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2206
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 3795 bits (9841), Expect = 0.0
Identities = 1887/1904 (99%), Positives = 1888/1904 (99%), Gaps = 11/1904 (0%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
Sbjct: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSW 1080
Query: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS
Sbjct: 1081 TSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGS 1140
Query: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD
Sbjct: 1141 LEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDD 1200
Query: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL
Sbjct: 1201 ADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
Sbjct: 1261 VIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR 1320
Query: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE
Sbjct: 1321 SSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVE 1380
Query: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV
Sbjct: 1381 TLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWV 1440
Query: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI
Sbjct: 1441 RHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLI 1500
Query: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-----------SKEK 1549
VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR S
Sbjct: 1501 VAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSAS 1560
Query: 1550 QMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1609
+EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
Sbjct: 1561 AASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1620
Query: 1610 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1669
KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI
Sbjct: 1621 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPI 1680
Query: 1670 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1729
NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE
Sbjct: 1681 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVE 1740
Query: 1730 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789
LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN
Sbjct: 1741 LFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1800
Query: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1849
TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH
Sbjct: 1801 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPH 1860
Query: 1850 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT 1893
SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT
Sbjct: 1861 SPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT 1904
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 2107 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2166
Query: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
+ AP P P WG K PP RS L LD +
Sbjct: 2167 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2201
Query: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2202 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2261
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2262 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2321
Query: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2322 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2354
Score = 296 bits (757), Expect = 2e-79
Identities = 163/228 (71%), Positives = 170/228 (74%), Gaps = 8/228 (3%)
Query: 1894 MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL 1953
MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL
Sbjct: 1998 MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL 2057
Query: 1954 SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS 2013
SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS
Sbjct: 2058 SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS 2117
Query: 2014 LDVQGLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGS 2073
LDVQGLGSREDLLAE PSP L + YS QS T R HS +S +
Sbjct: 2118 LDVQGLGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPP 2171
Query: 2074 QPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
P G +P+ G P +LS S + PP G PPSP
Sbjct: 2172 APCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2217
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 3782 bits (9807), Expect = 0.0
Identities = 1887/1927 (97%), Positives = 1888/1927 (97%), Gaps = 34/1927 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1538 RRLEKKRR-----------SKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1586
RRLEKKRR S +EAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1587 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1646
IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1647 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1706
AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1707 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1766
PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1767 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1826
GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE
Sbjct: 1801 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
Query: 1827 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1886
AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH
Sbjct: 1861 AKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASH 1920
Query: 1887 FSLEHPT 1893
FSLEHPT
Sbjct: 1921 FSLEHPT 1927
Score = 305 bits (781), Expect = 3e-82
Identities = 175/273 (64%), Positives = 184/273 (67%), Gaps = 35/273 (12%)
Query: 1909 VRKSGVSRTHSLPNDSYMCRHGSTAE--GPL-----GHRGWGLPKAQSGSVLSVHSQPAD 1961
+R+ RT SL R AE GP + WG Q+ HS+ +
Sbjct: 2130 LRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISK 2189
Query: 1962 TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2021
+ AP P P WG K PP RS L LD +
Sbjct: 2190 -----HMTPPAPC---PGPEPNWG---KGPPETRSSL--------------ELDTELSWI 2224
Query: 2022 REDLL---AEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2078
DLL +EEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG
Sbjct: 2225 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2284
Query: 2079 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2138
TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL
Sbjct: 2285 TDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPL 2344
Query: 2139 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2171
ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
Sbjct: 2345 ASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2377
Score = 296 bits (757), Expect = 2e-79
Identities = 163/228 (71%), Positives = 170/228 (74%), Gaps = 8/228 (3%)
Query: 1894 MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL 1953
MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL
Sbjct: 2021 MQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL 2080
Query: 1954 SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS 2013
SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS
Sbjct: 2081 SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS 2140
Query: 2014 LDVQGLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGS 2073
LDVQGLGSREDLLAE PSP L + YS QS T R HS +S +
Sbjct: 2141 LDVQGLGSREDLLAEVSGPSP-PLARAYSFWGQS----STQAQQHSRSHS-KISKHMTPP 2194
Query: 2074 QPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSP 2121
P G +P+ G P +LS S + PP G PPSP
Sbjct: 2195 APCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPP--GGQEEPPSP 2240
>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
isoform 15 [Homo sapiens]
Length = 1555
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 7e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
Query: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
Query: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
Query: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
Score = 107 bits (266), Expect = 2e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
Query: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
Query: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
Query: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
Query: 1816 LMKHLEESNKEAKEEA 1831
L++ + +E+A
Sbjct: 963 LVEGFQAEEISKREDA 978
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
Query: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
Score = 61.2 bits (147), Expect = 1e-08
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 35.8 bits (81), Expect = 0.47
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
Query: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 2306 bits (5975), Expect = 0.0
Identities = 1291/2157 (59%), Positives = 1482/2157 (68%), Gaps = 165/2157 (7%)
Query: 7 GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
GA E G P G P +AE+ E + +PYPALA VFF L Q
Sbjct: 27 GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
Query: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
+RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86 TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
Query: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD NVS SA+RTVRVLR
Sbjct: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
Query: 247 FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
F ++ R YYQTE +E+PFICS R+NGM+ C +P G PC L +EAY
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
Query: 306 NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
++ C+NWNQYY C +G+ NP GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
Query: 359 IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
Query: 419 NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
N STLASFSEPGSCYEELLKY+ +I RK RR ++ R P+ + GQ P
Sbjct: 443 NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
Query: 479 SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
R+ R SVHHLV HHHHHHHHHYH +G+ R P P D +R +
Sbjct: 501 GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
Query: 537 PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
P +P G P AESVHS YHADCH+E + +A + + A+ G G + YPT
Sbjct: 556 PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
Query: 593 V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
+ TSP P+ K GP +L S P PY + ++ G
Sbjct: 616 ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
Query: 643 ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
+S PC A + C SCPYC RA E EL+ E DSD VYEF
Sbjct: 671 QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
Query: 697 TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
TQD +H D DP RR + EP + W R+IV
Sbjct: 731 TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
Query: 741 DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL GP
Sbjct: 791 DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
Query: 801 GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
GYI+NPYNIFDG+IVVISVWEIVGQ GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 861 TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
Query: 920 LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 971 LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
Query: 980 PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030
D S + D + K C V+ H E R SL PPLI+ TAATPM PKS
Sbjct: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
Query: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090
+ P SRR SSS P + K P S RSSP +PW + +W+SRRSS +SL
Sbjct: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
Query: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150
GRAPSLKRR GER SLLSGEG+ S D+E P + R SL+
Sbjct: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
Query: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210
LP T + +D +G+ + LR D D + DD+ S
Sbjct: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
Query: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270
R+ + P C R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
Query: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330
A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG GE AYL+SSWN+LDGLL
Sbjct: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
Query: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390
VL+S++DI+V+M S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
Query: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450
NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C A YRWVR KYNFDNLG
Sbjct: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
Query: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510
QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
Query: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLV 1570
GVVVENFHKCRQHQE EEARRREEKRLRRLE++RRS EAQ +PYY+DYS R +
Sbjct: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPS-PEAQRRPYYADYSPTRRSI 1610
Query: 1571 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1630
H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++FV E+ KLVA
Sbjct: 1611 HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVA 1670
Query: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1690
FGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRVLRIARVLKLLK
Sbjct: 1671 FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLK 1730
Query: 1691 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHAT 1750
MA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E +PCEGL RHAT
Sbjct: 1731 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHAT 1790
Query: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIYFVSFVLTAQFV 1807
F NFGMAFLTLFRVSTGDNWNGIMKDTLR+C D+ Y +SP+YFV+FVL AQFV
Sbjct: 1791 FSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFV 1850
Query: 1808 LVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP 1867
LVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM +GP
Sbjct: 1851 LVNVVVAVLMKHLEESNKEAREDAELDAEIELEM-------------------AQGPG-- 1889
Query: 1868 DSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG----PDLLTVRKSGVSRTHSLPND 1923
SA + P P P E PG P+L+ RK VSR SLPND
Sbjct: 1890 ---------------SARRVDADRP---PLPQESPGARDAPNLV-ARKVSVSRMLSLPND 1930
Query: 1924 SYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH 1974
SYM R A P + G G P GSV SVHS PA++ LQ+P
Sbjct: 1931 SYMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGSVASVHSPPAESCASLQIP----- 1982
Query: 1975 LLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPP 2032
L A + + L P G RSP R L RQ A+ TDSL+ + + S D L EP
Sbjct: 1983 LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGK-IDSPRDTLDPAEPG 2041
Query: 2033 SPRDLKK-CYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS-----GSQPHLGTDPSN 2083
++ QS R P R+H+ C+ S G + +DP++
Sbjct: 2042 EKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPAD 2098
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 2303 bits (5967), Expect = 0.0
Identities = 1289/2157 (59%), Positives = 1481/2157 (68%), Gaps = 171/2157 (7%)
Query: 7 GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
GA E G P G P +AE+ E + +PYPALA VFF L Q
Sbjct: 27 GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
Query: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
+RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86 TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
Query: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD NVS SA+RTVRVLR
Sbjct: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
Query: 247 FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
F ++ R YYQTE +E+PFICS R+NGM+ C +P G PC L +EAY
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
Query: 306 NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
++ C+NWNQYY C +G+ NP GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
Query: 359 IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
Query: 419 NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
N STLASFSEPGSCYEELLKY+ +I RK RR ++ R P+ + GQ P
Sbjct: 443 NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
Query: 479 SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
R+ R SVHHLV HHHHHHHHHYH +G+ R P P D +R +
Sbjct: 501 GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
Query: 537 PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
P +P G P AESVHS YHADCH+E + +A + + A+ G G + YPT
Sbjct: 556 PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
Query: 593 V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
+ TSP P+ K GP +L S P PY + ++ G
Sbjct: 616 ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
Query: 643 ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
+S PC A + C SCPYC RA E EL+ E DSD VYEF
Sbjct: 671 QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
Query: 697 TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
TQD +H D DP RR + EP + W R+IV
Sbjct: 731 TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
Query: 741 DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL GP
Sbjct: 791 DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
Query: 801 GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
GYI+NPYNIFDG+IVVISVWEIVGQ GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 861 TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
Query: 920 LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 971 LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
Query: 980 PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030
D S + D + K C V+ H E R SL PPLI+ TAATPM PKS
Sbjct: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
Query: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090
+ P SRR SSS P + K P S RSSP +PW + +W+SRRSS +SL
Sbjct: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
Query: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150
GRAPSLKRR GER SLLSGEG+ S D+E P + R SL+
Sbjct: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
Query: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210
LP T + +D +G+ + LR D D + DD+ S
Sbjct: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
Query: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270
R+ + P C R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
Query: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330
A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG GE AYL+SSWN+LDGLL
Sbjct: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
Query: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390
VL+S++DI+V+M S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
Query: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450
NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C A YRWVR KYNFDNLG
Sbjct: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
Query: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510
QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
Query: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLV 1570
GVVVENFHKCRQHQE EEARRREEKRLRRLE++RR +AQ +PYY+DYS R +
Sbjct: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR-------KAQRRPYYADYSPTRRSI 1604
Query: 1571 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1630
H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++FV E+ KLVA
Sbjct: 1605 HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVA 1664
Query: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1690
FGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRVLRIARVLKLLK
Sbjct: 1665 FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLK 1724
Query: 1691 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHAT 1750
MA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E +PCEGL RHAT
Sbjct: 1725 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHAT 1784
Query: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIYFVSFVLTAQFV 1807
F NFGMAFLTLFRVSTGDNWNGIMKDTLR+C D+ Y +SP+YFV+FVL AQFV
Sbjct: 1785 FSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFV 1844
Query: 1808 LVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP 1867
LVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM +GP
Sbjct: 1845 LVNVVVAVLMKHLEESNKEAREDAELDAEIELEM-------------------AQGPG-- 1883
Query: 1868 DSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG----PDLLTVRKSGVSRTHSLPND 1923
SA + P P P E PG P+L+ RK VSR SLPND
Sbjct: 1884 ---------------SARRVDADRP---PLPQESPGARDAPNLV-ARKVSVSRMLSLPND 1924
Query: 1924 SYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH 1974
SYM R A P + G G P GSV SVHS PA++ LQ+P
Sbjct: 1925 SYMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGSVASVHSPPAESCASLQIP----- 1976
Query: 1975 LLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPP 2032
L A + + L P G RSP R L RQ A+ TDSL+ + + S D L EP
Sbjct: 1977 LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGK-IDSPRDTLDPAEPG 2035
Query: 2033 SPRDLKK-CYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS-----GSQPHLGTDPSN 2083
++ QS R P R+H+ C+ S G + +DP++
Sbjct: 2036 EKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPAD 2092
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 1461 bits (3782), Expect = 0.0
Identities = 797/1257 (63%), Positives = 927/1257 (73%), Gaps = 96/1257 (7%)
Query: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
A P SCP C +G G + + +E S S A E +A R
Sbjct: 512 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
Query: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 569 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
Query: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 629 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
Query: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 689 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
Query: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 749 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
Query: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 809 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
Query: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
C ++ H L P SLP G A GPA R +
Sbjct: 869 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
Query: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 912 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
Query: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 966 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
Query: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
Query: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
Query: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
Query: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
Query: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
Query: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
Query: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR +AQ PYY+
Sbjct: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1437
Query: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622
Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK CNY+FT +FVL
Sbjct: 1438 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1497
Query: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1498 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557
Query: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742
ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1617
Query: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799
EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C +++ +SP+YFVS
Sbjct: 1618 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1677
Query: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1855
FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P P P GSP
Sbjct: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1734
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
Query: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Y+ +ILRKA RR + +A R L AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
Query: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
Query: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
Query: 233 WAG 235
+ G
Sbjct: 1293 FKG 1295
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
Query: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
Query: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
+G E SG S ++ G G R A + G + E E V+
Sbjct: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
Query: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
Score = 55.5 bits (132), Expect = 6e-07
Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 965 EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020
F Q E + + S ++ + C + LRK+ L ++
Sbjct: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
Query: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073
A +ALGP + + G H P + ++PH+ P
Sbjct: 459 ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
Query: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129
+ AS S ++ GR PS + SG+ S GE + D SSE+ +S
Sbjct: 509 ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
Query: 1130 PAGSD 1134
G +
Sbjct: 569 ELGKE 573
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
Query: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532
++N+ + V+ F K R+H+ E R+R
Sbjct: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
Query: 396 TQF 398
F
Sbjct: 828 EGF 830
Score = 38.9 bits (89), Expect = 0.055
Identities = 84/315 (26%), Positives = 114/315 (36%), Gaps = 59/315 (18%)
Query: 1888 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1936
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
Query: 1937 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1990
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
Query: 1991 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS--------REDLLAEEEP------ 2031
G RSP L RQA SLD S + L + P
Sbjct: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGP 2013
Query: 2032 ----PSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS---GSQPHLGTDPSN- 2083
P PR + S + R L R H + S S G H DPS+
Sbjct: 2014 PAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDE 2073
Query: 2084 --LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KD 2136
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S
Sbjct: 2074 EGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGR 2129
Query: 2137 PLASGPPDSMAASPS 2151
P A+ +A SPS
Sbjct: 2130 PHAAALAHGLARSPS 2144
Score = 38.1 bits (87), Expect = 0.095
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
Score = 37.7 bits (86), Expect = 0.12
Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)
Query: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
Query: 1811 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1855
+ + V+ E+ ++ E LE + LS + P
Sbjct: 392 LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
Query: 1856 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1899
L+ ++ GP++P KPG HA+ H+ L +H + P
Sbjct: 447 RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
Query: 1900 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1950
L P T+ S P C+H G R GL SG
Sbjct: 502 TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 1461 bits (3782), Expect = 0.0
Identities = 797/1257 (63%), Positives = 927/1257 (73%), Gaps = 96/1257 (7%)
Query: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
A P SCP C +G G + + +E S S A E +A R
Sbjct: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
Query: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
Query: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
Query: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
Query: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
Query: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
Query: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
C ++ H L P SLP G A GPA R +
Sbjct: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
Query: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
Query: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
Query: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
Query: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
Query: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
Query: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
Query: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
Query: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
Query: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR +AQ PYY+
Sbjct: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1472
Query: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622
Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK CNY+FT +FVL
Sbjct: 1473 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1532
Query: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1533 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592
Query: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742
ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1652
Query: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799
EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C +++ +SP+YFVS
Sbjct: 1653 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1712
Query: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1855
FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P P P GSP
Sbjct: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1769
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
Query: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Y+ +ILRKA RR + +A R L AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
F SE++ R+ L L E R+ L + + A P
Sbjct: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
Query: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
+ + L A RR A + ++P A+ PH+
Sbjct: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
Query: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
+ R+ G+ G+G E + + PA + H G
Sbjct: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
Query: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
Query: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
Query: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
Query: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 233 WAG 235
+ G
Sbjct: 1328 FKG 1330
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
Query: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
Query: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
+G E SG S ++ G G R A + G + E E V+
Sbjct: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
Query: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
Query: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532
++N+ + V+ F K R+H+ E R+R
Sbjct: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 396 TQF 398
F
Sbjct: 863 EGF 865
Score = 38.9 bits (89), Expect = 0.055
Identities = 84/315 (26%), Positives = 114/315 (36%), Gaps = 59/315 (18%)
Query: 1888 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1936
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
Query: 1937 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1990
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
Query: 1991 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS--------REDLLAEEEP------ 2031
G RSP L RQA SLD S + L + P
Sbjct: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGP 2048
Query: 2032 ----PSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS---GSQPHLGTDPSN- 2083
P PR + S + R L R H + S S G H DPS+
Sbjct: 2049 PAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDE 2108
Query: 2084 --LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KD 2136
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S
Sbjct: 2109 EGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGR 2164
Query: 2137 PLASGPPDSMAASPS 2151
P A+ +A SPS
Sbjct: 2165 PHAAALAHGLARSPS 2179
Score = 38.1 bits (87), Expect = 0.095
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 34.7 bits (78), Expect = 1.0
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
Query: 1811 VVIAVLMKHLEESNK 1825
+ + V+ E+ +
Sbjct: 392 LCLVVIATQFSETKQ 406
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 449 bits (1155), Expect = e-125
Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
F A+ A + E + +L G K+ C L L + P+ +L
Sbjct: 942 FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
Query: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
LP I ATP S P + E + P + T +PG + P
Sbjct: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
Query: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
P + A S T NSLG S + QESQ E S
Sbjct: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
Query: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
S S E EA +S D Q A G G E G +A L
Sbjct: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
P L D D E ++G R P C ++ ++ R R C+ I
Sbjct: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+ EM +K VA
Sbjct: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
G+ + Y ++W LD L+V +S++ ++ + + G +G ++ LR LR LRPLR +
Sbjct: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C +G+ N
Sbjct: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
Query: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
T NKS C + W + K NFDN+G ++L +A+ GW+DIMY +D+ G
Sbjct: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537
++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
Query: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
KK SK+ Q KP ++++ + + T D+ I +I LN+VTM +E
Sbjct: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
Query: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Q P+ ++ KI N +F IF E + KL A +F + WN D +V+LSI+G
Sbjct: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
Query: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
Query: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
L+ FI++ G+ F ++ + G+ F+ F + L LF+++T W+G++
Sbjct: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
Query: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
L CD C + + ++F ++++ + ++VN+ IA+++++ +
Sbjct: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
Query: 1825 KEAKE 1829
+E+ E
Sbjct: 1780 EESTE 1784
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
Score = 132 bits (332), Expect = 4e-30
Identities = 195/900 (21%), Positives = 352/900 (39%), Gaps = 203/900 (22%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
G F ++++P+N D VI++ E V G +S LRTFR++R LK + + L+
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
Query: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
+ L++++ +A +L + + +F+++G+ LF + R+ L D
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 908 SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
L+W + ++ L + + VL G +S +
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 938 -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
+WA L LMT G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
+ A +E+E + +K+ AL G R SL + PL P++
Sbjct: 418 EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
+ S R+ SSG+ E G KS S P R +
Sbjct: 472 HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
SL R S P R S+ + ++ E + +++E ++ S+ H L
Sbjct: 509 LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
R + P T PG LH G + DCNG S L R
Sbjct: 569 RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
+ + PP +++ +G G R RA + LE S +
Sbjct: 622 VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
PP R+ + ++ D + + I LN + +A+E +
Sbjct: 682 KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
E L + N +FT +F AEMT K++AL + Y + WN+ D ++V++S+++
Sbjct: 742 TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
+ +S +S+ L VLR R LR ++ L +++ + +S+ +GN+ ++
Sbjct: 796 LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
IF ++G+QLF + + D+ + RW H +F + A + +F
Sbjct: 848 IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
+ + W++ M+D ++ G LL F+ ++I VLN+F+ +++ +F
Sbjct: 893 RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
Score = 118 bits (296), Expect = 6e-26
Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I +DL NVS A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ + ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 115 bits (288), Expect = 5e-25
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
Query: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
Query: 1818 KHLEESNKEAKEEAELEAELELEM 1841
N A +E L+L +
Sbjct: 940 SSFSADNLTAPDEDREMNNLQLAL 963
Score = 102 bits (254), Expect = 4e-21
Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)
Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
FTA++ E VK++A G+C +LR WN LD +++++ V LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
+ LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1543 KRRS 1546
+ +
Sbjct: 444 EHEA 447
Score = 92.4 bits (228), Expect = 4e-18
Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
Query: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
Query: 953 YVLFNLLVAILVEGFQAE 970
+ NL + ++++ F +
Sbjct: 1459 FFTLNLFIGVIIDNFNQQ 1476
Score = 89.0 bits (219), Expect = 5e-17
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
Query: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
Query: 951 GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
++ N+ +AI++E F A ++ + SE DF
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
Score = 72.4 bits (176), Expect = 5e-12
Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)
Query: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
K++A GF F +D WN LD +++ IM T E +++ + R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
Query: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 8e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Score = 32.7 bits (73), Expect = 4.0
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 449 bits (1155), Expect = e-125
Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
F A+ A + E + +L G K+ C L L + P+ +L
Sbjct: 942 FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
Query: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
LP I ATP S P + E + P + T +PG + P
Sbjct: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
Query: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
P + A S T NSLG S + QESQ E S
Sbjct: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
Query: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
S S E EA +S D Q A G G E G +A L
Sbjct: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
P L D D E ++G R P C ++ ++ R R C+ I
Sbjct: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+ EM +K VA
Sbjct: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
G+ + Y ++W LD L+V +S++ ++ + + G +G ++ LR LR LRPLR +
Sbjct: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C +G+ N
Sbjct: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
Query: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
T NKS C + W + K NFDN+G ++L +A+ GW+DIMY +D+ G
Sbjct: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537
++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
Query: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
KK SK+ Q KP ++++ + + T D+ I +I LN+VTM +E
Sbjct: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
Query: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Q P+ ++ KI N +F IF E + KL A +F + WN D +V+LSI+G
Sbjct: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
Query: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
Query: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
L+ FI++ G+ F ++ + G+ F+ F + L LF+++T W+G++
Sbjct: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
Query: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
L CD C + + ++F ++++ + ++VN+ IA+++++ +
Sbjct: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
Query: 1825 KEAKE 1829
+E+ E
Sbjct: 1780 EESTE 1784
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
Score = 136 bits (342), Expect = 3e-31
Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
G F ++++P+N D VI++ V E + + G LS LRTFR++R LK + +P L+
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
+ L++++ +A +L + + +F+++G+ LF + R+ L D
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 908 SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
L+W + ++ L + + VL G +S +
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 938 -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
+WA L LMT G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
+ A +E+E + +K+ AL G R SL + PL P++
Sbjct: 418 EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
+ S R+ SSG+ E G KS S P R +
Sbjct: 472 HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
SL R S P R S+ + ++ E + +++E ++ S+ H L
Sbjct: 509 LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
R + P T PG LH G + DCNG S L R
Sbjct: 569 RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
+ + PP +++ +G G R RA + LE S +
Sbjct: 622 VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
PP R+ + ++ D + + I LN + +A+E +
Sbjct: 682 KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
E L + N +FT +F AEMT K++AL + Y + WN+ D ++V++S+++
Sbjct: 742 TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
+ +S +S+ L VLR R LR ++ L +++ + +S+ +GN+ ++
Sbjct: 796 LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
IF ++G+QLF + + D+ + RW H +F + A + +F
Sbjct: 848 IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
+ + W++ M+D ++ G LL F+ ++I VLN+F+ +++ +F
Sbjct: 893 RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 115 bits (288), Expect = 5e-25
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
Query: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
Query: 1818 KHLEESNKEAKEEAELEAELELEM 1841
N A +E L+L +
Sbjct: 940 SSFSADNLTAPDEDREMNNLQLAL 963
Score = 103 bits (257), Expect = 2e-21
Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)
Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1543 KRRS 1546
+ +
Sbjct: 444 EHEA 447
Score = 92.4 bits (228), Expect = 4e-18
Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
Query: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
Query: 953 YVLFNLLVAILVEGFQAE 970
+ NL + ++++ F +
Sbjct: 1459 FFTLNLFIGVIIDNFNQQ 1476
Score = 89.0 bits (219), Expect = 5e-17
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
Query: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
Query: 951 GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
++ N+ +AI++E F A ++ + SE DF
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
Query: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 8e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Score = 32.7 bits (73), Expect = 4.0
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 447 bits (1151), Expect = e-125
Identities = 329/1145 (28%), Positives = 562/1145 (49%), Gaps = 108/1145 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
F A+ A + E + +L G K+ C L L + P+ +L
Sbjct: 942 FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
Query: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
LP I ATP S P + E + P + T +PG + P
Sbjct: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
Query: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
P + A S T NSLG + QESQ E S
Sbjct: 1047 VPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVSGGPEAPPDS 1091
Query: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
S S E EA +S D Q A G G E G +A L
Sbjct: 1092 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1149
Query: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
P L D D E ++G R P C ++ ++ R R C+ I
Sbjct: 1150 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1200
Query: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+ EM +K VA
Sbjct: 1201 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1260
Query: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
G+ + Y ++W LD L+V +S++ ++ + + G +G ++ LR LR LRPLR +
Sbjct: 1261 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1313
Query: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C +G+ N
Sbjct: 1314 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1373
Query: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
T NKS C + W + K NFDN+G ++L +A+ GW+DIMY +D+ G
Sbjct: 1374 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1433
Query: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537
++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1434 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1493
Query: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
KK SK+ Q KP ++++ + + T D+ I +I LN+VTM +E
Sbjct: 1494 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1547
Query: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Q P+ ++ KI N +F IF E + KL A +F + WN D +V+LSI+G
Sbjct: 1548 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1605
Query: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1606 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1663
Query: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
L+ FI++ G+ F ++ + G+ F+ F + L LF+++T W+G++
Sbjct: 1664 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1718
Query: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
L CD C + + ++F ++++ + ++VN+ IA+++++ +
Sbjct: 1719 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1778
Query: 1825 KEAKE 1829
+E+ E
Sbjct: 1779 EESTE 1783
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520
Score = 132 bits (332), Expect = 4e-30
Identities = 195/900 (21%), Positives = 352/900 (39%), Gaps = 203/900 (22%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
G F ++++P+N D VI++ E V G +S LRTFR++R LK + + L+
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
Query: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
+ L++++ +A +L + + +F+++G+ LF + R+ L D
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 908 SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
L+W + ++ L + + VL G +S +
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 938 -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
+WA L LMT G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
+ A +E+E + +K+ AL G R SL + PL P++
Sbjct: 418 EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
+ S R+ SSG+ E G KS S P R +
Sbjct: 472 HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
SL R S P R S+ + ++ E + +++E ++ S+ H L
Sbjct: 509 LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
R + P T PG LH G + DCNG S L R
Sbjct: 569 RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
+ + PP +++ +G G R RA + LE S +
Sbjct: 622 VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
PP R+ + ++ D + + I LN + +A+E +
Sbjct: 682 KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
E L + N +FT +F AEMT K++AL + Y + WN+ D ++V++S+++
Sbjct: 742 TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
+ +S +S+ L VLR R LR ++ L +++ + +S+ +GN+ ++
Sbjct: 796 LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
IF ++G+QLF + + D+ + RW H +F + A + +F
Sbjct: 848 IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
+ + W++ M+D ++ G LL F+ ++I VLN+F+ +++ +F
Sbjct: 893 RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
Score = 118 bits (296), Expect = 6e-26
Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I +DL NVS A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ + ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 115 bits (288), Expect = 5e-25
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
Query: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
Query: 1818 KHLEESNKEAKEEAELEAELELEM 1841
N A +E L+L +
Sbjct: 940 SSFSADNLTAPDEDREMNNLQLAL 963
Score = 102 bits (254), Expect = 4e-21
Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)
Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
FTA++ E VK++A G+C +LR WN LD +++++ V LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
+ LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1543 KRRS 1546
+ +
Sbjct: 444 EHEA 447
Score = 92.4 bits (228), Expect = 4e-18
Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1159 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1217
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1218 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1277
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1278 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1337
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1338 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1397
Query: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 1398 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1457
Query: 953 YVLFNLLVAILVEGFQAE 970
+ NL + ++++ F +
Sbjct: 1458 FFTLNLFIGVIIDNFNQQ 1475
Score = 89.0 bits (219), Expect = 5e-17
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1582
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1583 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1641
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1642 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1697
Query: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1698 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1757
Query: 951 GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
++ N+ +AI++E F A ++ + SE DF
Sbjct: 1758 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1790
Score = 72.4 bits (176), Expect = 5e-12
Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)
Query: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
K++A GF F +D WN LD +++ IM T E +++ + R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
Query: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 8e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1529 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1581
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1582 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1640
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1641 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679
Score = 32.7 bits (73), Expect = 4.0
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 436 bits (1120), Expect = e-121
Identities = 313/1131 (27%), Positives = 557/1131 (49%), Gaps = 133/1131 (11%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025
F A+ + +P D + + + LA + G +
Sbjct: 942 FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
Query: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083
K T+ G +R +P A PS ++P+SP + +R
Sbjct: 971 RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
Query: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143
+ +R G P + +P + ES +++ +EE SL
Sbjct: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
Query: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203
E +SS P+ S SE G +A L P L D D
Sbjct: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
Query: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263
E ++G R P C ++ ++ R R C+ I+ H F+ ++ +I
Sbjct: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
Query: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323
L+ +A E ++ ++ L ++ +FT VF+ EM +K VA G+ + Y ++W
Sbjct: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
Query: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383
LD L+V +S++ ++ + + G +G ++ LR LR LRPLR +SR +G+++VV L+
Sbjct: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
Query: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436
++ I N++++C F++IF I+GV LF GKF C +G+ N T NKS C +
Sbjct: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
Query: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492
W + K NFDN+G ++L +A+ GW+DIMY +D+ G ++QP +N +M +
Sbjct: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
Query: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQM 1551
YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+ KK SK+ Q
Sbjct: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ- 1453
Query: 1552 AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALK 1610
KP ++++ + + T D+ I +I LN+VTM +E Q P+ ++ K
Sbjct: 1454 -----KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAK 1508
Query: 1611 ICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPIN 1670
I N +F IF E + KL A +F + WN D +V+LSI+G L +I +
Sbjct: 1509 I-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFS 1564
Query: 1671 PTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVEL 1730
PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL L+ FI++ G+
Sbjct: 1565 PTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN 1624
Query: 1731 FGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD---- 1782
F ++ + G+ F+ F + L LF+++T W+G++ L CD
Sbjct: 1625 FAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP 1679
Query: 1783 ----QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
C + + ++F ++++ + ++VN+ IA+++++ + +E+ E
Sbjct: 1680 NSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1730
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1309 CINQTEGDLPL------------------------------------------------- 1319
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
Score = 136 bits (342), Expect = 3e-31
Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
G F ++++P+N D VI++ V E + + G LS LRTFR++R LK + +P L+
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
+ L++++ +A +L + + +F+++G+ LF + R+ L D
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 908 SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
L+W + ++ L + + VL G +S +
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 938 -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
+WA L LMT G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
+ A +E+E + +K+ AL G R SL + PL P++
Sbjct: 418 EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
Query: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
+ S R+ SSG+ E G KS S P R +
Sbjct: 472 HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
Query: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
SL R S P R S+ + ++ E + +++E ++ S+ H L
Sbjct: 509 LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
Query: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
R + P T PG LH G + DCNG S L R
Sbjct: 569 RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
Query: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
+ + PP +++ +G G R RA + LE S +
Sbjct: 622 VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
Query: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
PP R+ + ++ D + + I LN + +A+E +
Sbjct: 682 KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
Query: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
E L + N +FT +F AEMT K++AL + Y + WN+ D ++V++S+++
Sbjct: 742 TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
Query: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
+ +S +S+ L VLR R LR ++ L +++ + +S+ +GN+ ++
Sbjct: 796 LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
IF ++G+QLF + + D+ + RW H +F + A + +F
Sbjct: 848 IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
Query: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
+ + W++ M+D ++ G LL F+ ++I VLN+F+ +++ +F
Sbjct: 893 RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 115 bits (288), Expect = 5e-25
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
Query: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
Query: 1818 KHLEESNKEAKEEAELEAELELEM 1841
N A +E L+L +
Sbjct: 940 SSFSADNLTAPDEDREMNNLQLAL 963
Score = 103 bits (257), Expect = 2e-21
Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)
Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
F G D N SD
Sbjct: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
Query: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
Query: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Query: 1543 KRRS 1546
+ +
Sbjct: 444 EHEA 447
Score = 92.8 bits (229), Expect = 3e-18
Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)
Query: 610 VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669
+A PP + +PP + + E G + P A+S D
Sbjct: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
Query: 670 CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712
G E + ++ P DS SE + + T A+ D++DP RR
Sbjct: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
Query: 713 QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770
D + +WRL T IV+ +F I+ IL+++ ++ E Y E+ +
Sbjct: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
Query: 771 LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825
+ LE ++ +FT +F LEMLLK + YG Y N + D +IV +S+ +V
Sbjct: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
Query: 826 QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885
+ G + LRT R +R L+ + ++ + L+ + ++ ++ ++F IFSI+G++
Sbjct: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
Query: 886 LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918
LF KF ++ +GD T+ + K NFD++ + + Q
Sbjct: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
Query: 919 ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968
+ T + W ++Y G W +YF+ + FG++ NL + ++++ F
Sbjct: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
Query: 969 AE 970
+
Sbjct: 1421 QQ 1422
Score = 89.0 bits (219), Expect = 5e-17
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
Query: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
Query: 951 GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
++ N+ +AI++E F A ++ + SE DF
Sbjct: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
Query: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
Query: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747
VE G DL C E + C G
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
Query: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 8e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
Score = 32.7 bits (73), Expect = 4.0
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 425 bits (1092), Expect = e-118
Identities = 317/1128 (28%), Positives = 551/1128 (48%), Gaps = 111/1128 (9%)
Query: 749 IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
I + I+VNT+ M +E+H L+I NIVFT F EM+ K++ + P+ Y + +N
Sbjct: 671 ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
Query: 809 IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
IFD +IV +S+ E+ + G LSVLR+FRL+RV KL + P L + ++ ++ +
Sbjct: 731 IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
Query: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924
++L + +F+F+++G L G + + R + P R + + + VF+IL E
Sbjct: 791 TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
Query: 925 WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFF 983
W + ++ M S + F+ +M GN V+ NL +A+L+ F A+ +
Sbjct: 850 WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD----------NLT 899
Query: 984 SPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEA-LGP 1041
+P DG+ + + LA + + H +++L + + P PK+ + + L
Sbjct: 900 APEDDGEVNNLQVALARIQVFGH-RTKQALCS---FFSRSCPFPQPKAEPELVVKLPLSS 955
Query: 1042 ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-WTSRRSSRNSLGRAPSLKRRS 1100
+ + + G++ +++P R HS + A + W S + G +
Sbjct: 956 SKAENHIAANTARGSSGGLQAPRGPRDE-HSDFIANPTVWVSVPIAE---GESDLDDLED 1011
Query: 1101 PSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTL----- 1155
GE E +E+ + ER DH S SS DL +L
Sbjct: 1012 DGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTPRS-PGTGTSSEDLAPSLGETWK 1066
Query: 1156 -----QVP--GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLS 1208
QVP G+ T+S GS DC R L D + DD EG +
Sbjct: 1067 DESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKIPELADDLE--EPDDCFTEGCIR 1121
Query: 1209 KGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLN 1266
P C L+ + W + R C+RI+ H F+ ++ +I L+
Sbjct: 1122 -----------HCPCCKLDTTKSPWDV-----GWQVRKTCYRIVEHSWFESFIIFMILLS 1165
Query: 1267 CITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326
++A E +D + L ++ +FT +F+ EM +K VA G+ + Y ++W L
Sbjct: 1166 SGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWL 1221
Query: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386
D L+V IS+I + ++ S + ++ LR LR LRPLR +SR +G+++VV+ L+ ++
Sbjct: 1222 DFLIVNISLISLTAKILEYSE---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278
Query: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDT----RNITNKSDC----AE 1434
I N++++C F++IF I+GV LF GKF+ C GE + + NKSDC +
Sbjct: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338
Query: 1435 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1494
S+ WV K NFDN+ ++L +A+ GW+DIMY +D+ V+ QP N +M LYF
Sbjct: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398
Query: 1495 ISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAE 1553
+ F++ FF LN+FVGV+++NF++ ++ ++ E+K+ KK SK+ Q
Sbjct: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ--- 1455
Query: 1554 AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICN 1613
KP ++F+ V + T D+ I +I LN++TM +E Q + + L N
Sbjct: 1456 ---KPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKIN 1512
Query: 1614 YIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI 1673
F +F E V K+ A + +F + WN D +V+LSI + I + +PT+
Sbjct: 1513 QFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTL 1571
Query: 1674 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733
R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL L+ FI++ G+ F
Sbjct: 1572 FRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPH 1631
Query: 1734 LECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD------- 1782
+ + G+ F+ F + L LF+++T W+G++ L CD
Sbjct: 1632 VRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSN 1686
Query: 1783 -QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
C + + I+F ++++ + ++VN+ IAV++++ + +E+ E
Sbjct: 1687 GTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
Score = 149 bits (375), Expect = 4e-35
Identities = 186/876 (21%), Positives = 350/876 (39%), Gaps = 168/876 (19%)
Query: 723 SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777
S+ A W LI T K+ +F I + ILVN + M T+ E
Sbjct: 105 SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
Query: 778 SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832
VFT ++ E L+K+L G F Y+++P+N D VI + V + +G +S
Sbjct: 156 IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
Query: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888
LRTFR++R LK V +P L+ + L+ ++ +A +L + + +F+++G+ LF
Sbjct: 214 LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
Query: 889 -------------CKFASERDGDTLPDRK------------------------------- 904
++S R D +++
Sbjct: 274 NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
Query: 905 ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
+FDS WA +++F+++TQ+ W ++ + ++ ++F+ ++ G++ L NL++
Sbjct: 334 FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL 393
Query: 961 AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIH 1019
A++ ++ + A E E ++K AL L + E+ +L + +H
Sbjct: 394 AVVTMAYEEQNQATTDEIEAK----------EKKFQEALEMLRKEQEVLAALGIDTTSLH 443
Query: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1079
+ K+ S RR G+ + KSP S + +
Sbjct: 444 SHNGSPLTSKNAS----------ERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLA 493
Query: 1080 WTSRRSSRNSLG--RAPSLKRRSPSG-------------ERRSLLSGEGQESQDEEESSE 1124
RR+S S+ R+P P G R SLL G G Q S
Sbjct: 494 SGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSP 553
Query: 1125 EERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQD--CNGKSAS 1182
+ P+ D RH + +S P + V ++E+ D + A
Sbjct: 554 LPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAM 611
Query: 1183 GRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRF 1242
++ + + + S ++ W CC P +
Sbjct: 612 SVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW------DCC-----------PMWVKL 654
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
+ + ++T + + + I +N I +AME + P L + N +FT F AEM
Sbjct: 655 KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEM 712
Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
K++A F Y + WN+ D ++V +S++++ G G L VLR R
Sbjct: 713 VFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL--------GVAKKGSLSVLRSFRL 760
Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
LR ++ L +++ + +S+ +GN+ +I +F ++G QL GE+
Sbjct: 761 LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GEN 812
Query: 1423 TRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ 1481
RN N+ + + W R H ++F L+ +L + W++ M+ ++ V Q+
Sbjct: 813 YRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRILCGE--WIENMWACME---VGQK 863
Query: 1482 PIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
I L+ F++ +++ VLN+F+ +++ +F
Sbjct: 864 SI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
Score = 128 bits (321), Expect = 7e-29
Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128
R C R V + WFE + +ILL+ +L ED D + + L + D +F F F
Sbjct: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
Query: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181
EM++K VA +G K Y + W LDF IV A +LEYS + A+RT
Sbjct: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
Query: 182 VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG RC
Sbjct: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
Query: 242 --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298
+ FSL PLS+ N C+
Sbjct: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
Query: 299 GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
NS+ + VN + N + G ++A+ QV T +GW+D
Sbjct: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
Query: 359 IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405
IMY +D+ + Y ++YF++ II G FF +NL + VI F++ K++ +
Sbjct: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
Query: 406 SQLMREQRVRFLSNASTLAS 425
M E++ ++ + L S
Sbjct: 1432 DIFMTEEQKKYYNAMKKLGS 1451
Score = 118 bits (296), Expect = 6e-26
Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R ++ + WF + IL+NCV + R + + + +
Sbjct: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
E ++K++A G + YL D WN LDF ++ + ++DL+ +S +RT RVLR L+
Sbjct: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
Query: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
++ +P ++++V L+ ++ L +V +L F +F +VG+QL+ G L+N+C +
Sbjct: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
Query: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309
++V+ Y + + P I R S P L G+G C Y +S
Sbjct: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
Query: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369
NP +FD+ +A++++F+++T + W + +
Sbjct: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
Query: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+ + E Q + + + +F
Sbjct: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
Score = 108 bits (270), Expect = 6e-23
Identities = 81/351 (23%), Positives = 151/351 (43%), Gaps = 67/351 (19%)
Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
++F P + R ++ H F + V I +NC+ M R + P E Y+
Sbjct: 111 WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
FT ++ E +K++A G+C E YLR WN LD ++ ++ + + + SG
Sbjct: 160 FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
LR R LR L+ +S GLK++V L+ S+K + ++ ++ +F ++G+QLFKG
Sbjct: 214 ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
Query: 1414 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1437
+C G D+ + + C + S
Sbjct: 271 NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
Query: 1438 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1497
+ +FD+ A +SLF L ++D W + QQ + +++F+
Sbjct: 331 NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
Query: 1498 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKE 1548
+ + +F+++N+ + VV + + Q +E +E+K LE R+ +E
Sbjct: 381 IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
Score = 103 bits (257), Expect = 2e-21
Identities = 78/301 (25%), Positives = 144/301 (47%), Gaps = 36/301 (11%)
Query: 1547 KEKQMAEAQCKPYYSDYS-------------RFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593
+E + +E +C P + S + + ++ L T + +L IT I +N +
Sbjct: 622 EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
Query: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653
MAMEH+ + L+I N +FT+ F E VFK++AF +FQ +WN D IV +S+
Sbjct: 682 MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
Query: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713
+ + + + + ++R R+ RV KL K + L+ + ++ +GNL
Sbjct: 742 LELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT 791
Query: 1714 LLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1769
++ ++ F+FA +G +L G+ + + P E R +F +FL +FR+ G+
Sbjct: 792 IILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILCGE- 849
Query: 1770 WNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
W M + + Q+S C I F++ ++ V++N+ IA+L+ N A E
Sbjct: 850 WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 902
Query: 1830 E 1830
+
Sbjct: 903 D 903
Score = 92.4 bits (228), Expect = 4e-18
Identities = 109/469 (23%), Positives = 188/469 (40%), Gaps = 123/469 (26%)
Query: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619
+S ++ R + + LFIT I +N V M L E ++ Y+FTVI
Sbjct: 113 FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
Query: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
+ E++ K++A GF + +D WN LD +++ L+ +G ++ ++
Sbjct: 164 YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
Query: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1731
+R R+ R LK + + G++ ++ ++ ++ ++ ++ +L + +FA +G++LF
Sbjct: 214 -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
Query: 1732 ------GDLECDET-------------------------------HPCEGL--------- 1745
D+ +ET H +G
Sbjct: 273 KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
Query: 1746 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804
+ +F +F AFL+LFR+ T D+W + + TLR + I I+FV +
Sbjct: 333 DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
Query: 1805 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1846
F LVN+++AV+ EE N+ EAKE E E+ A L ++ +L
Sbjct: 385 SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
Query: 1847 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1889
SPL S + P V + D+ P + L A+ R ASH S+
Sbjct: 445 HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
Query: 1890 EHPTMQPHPTELPGPDLLTVRKSGV-SRTHSLPNDSYMCRHGSTAEGPL 1937
H LP V GV H S + G+ +GPL
Sbjct: 505 FHFRSPGRDISLPE----GVTDDGVFPGDHESHRGSLLLGGGAGQQGPL 549
Score = 87.4 bits (215), Expect = 1e-16
Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 36/275 (13%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM+ I +N ++M +E +Q EE T L N F ++F E ++K+
Sbjct: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848
+ Y N +N+FD ++VV+S+ ++ V+R R+ R+L+L+R
Sbjct: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
++ L LM ++ + +LL L +FI+SI GM F R + D NF +
Sbjct: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
Query: 909 LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948
+++ +FQI T W+ +L G + + ++F +
Sbjct: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
Query: 949 TFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
++ N+ +A+++E F A ++ + SE DF
Sbjct: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDF 1741
Score = 87.0 bits (214), Expect = 2e-16
Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 45/281 (16%)
Query: 735 TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792
T +IV+ +F I+ IL+++ S+ E Y +Q + LE ++ VFT +F EMLL
Sbjct: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
Query: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847
K + YG Y N + D +IV IS+ + + + + LRT R +R L+ +
Sbjct: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
Query: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898
++ + L+ + ++ ++ ++F IFSI+G++LF KF + DG+
Sbjct: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
Query: 899 TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935
++ + K NFD++ + + Q+ T + W ++Y + S
Sbjct: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
Query: 936 ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
+ + LYF+ + FG + NL V ++++ F +
Sbjct: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424
Score = 65.9 bits (159), Expect = 4e-10
Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M++I LN +T+ + E ++ +IL + F A F E V+KM AL
Sbjct: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
Query: 143 GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193
++ Y + WN DF +V+ + L +S L+++ F +R R+ R LR I
Sbjct: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
Query: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
+R L+ L+ +LP L N+ LL F V FI+ I G+
Sbjct: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
Score = 63.9 bits (154), Expect = 2e-09
Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)
Query: 47 EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101
E+E P L + YL D P L+T V +P+ E L I++N + + M
Sbjct: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
Query: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161
E +LQ + FF EMV K++A F Y WN D IV
Sbjct: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
Query: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221
+LE + + S S +R+ R+LR + P++ L+ ++ +++ LGN+ ++ +
Sbjct: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
Query: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250
F+F +VG QL RN +N S P
Sbjct: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 350 bits (898), Expect = 9e-96
Identities = 198/597 (33%), Positives = 339/597 (56%), Gaps = 36/597 (6%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
Query: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
Query: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1421
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
Query: 1422 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1536
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
Query: 1537 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
KK SK+ Q KP ++ + LV + TS D+ I +I LN+++M
Sbjct: 1332 YYNAMKKLGSKKPQ------KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMA 1385
Query: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
E Y QP+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+
Sbjct: 1386 ESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVST 1444
Query: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
+ +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1445 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLL 1504
Query: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
L+ FI+A LG+ F + +P G+ F+ F + L LF++ST W+ ++
Sbjct: 1505 FLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSP 1559
Query: 1777 TLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1560 MLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
Score = 125 bits (315), Expect = 3e-28
Identities = 76/270 (28%), Positives = 141/270 (52%), Gaps = 22/270 (8%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
Query: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
Query: 955 LFNLLVAILVEGF-------QAEGDANKSE 977
+ NL +A+L+ F EG+A K++
Sbjct: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTK 831
Score = 116 bits (290), Expect = 3e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
Query: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
Query: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
Query: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
+S D + E D C + +EN + C G G C + YE
Sbjct: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
Query: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
Query: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Score = 113 bits (283), Expect = 2e-24
Identities = 83/345 (24%), Positives = 164/345 (47%), Gaps = 55/345 (15%)
Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
Query: 1414 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1444
C D +NI+N S C+ E + + Y
Sbjct: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
Query: 1445 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1501
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
Query: 1502 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRR 1545
+F+++N+ + VV + + ++ E EA+ + + ++L K+ +
Sbjct: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
Query: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1355
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
Query: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
Query: 1476 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
Score = 103 bits (257), Expect = 2e-21
Identities = 79/307 (25%), Positives = 142/307 (46%), Gaps = 35/307 (11%)
Query: 1547 KEKQMAEAQCKP----YYSDYSRFRLLVHHLC---------TSHYLDLFITGVIGLNVVT 1593
KE++ ++ C P S Y + LC T + +L IT I +N V
Sbjct: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
Query: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653
+AMEH++ ++ L I N +FT IF+ E K++A +F+ WN D + LLS
Sbjct: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
Query: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713
+ + + S P +R R+ RV KL K + L+ + ++ +G+L
Sbjct: 654 ADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLT 705
Query: 1714 LLFMLLFFIFAALGVELFG--------DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
++ +++ FIF+ +G++LFG C+ T P RH +F +FL +FR+
Sbjct: 706 VVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRIL 765
Query: 1766 TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1825
G+ W + + +C QE+ ++ + I F+ + + V++N+ IA+L+ +
Sbjct: 766 CGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
Query: 1826 EAKEEAE 1832
E E
Sbjct: 820 NGNLEGE 826
Score = 96.7 bits (239), Expect = 2e-19
Identities = 75/267 (28%), Positives = 133/267 (49%), Gaps = 28/267 (10%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
Query: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
++ L LM ++ ++ +LL L +FI++ILGM+ F K E D + + K F S
Sbjct: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-KVNPESGIDDIFNFKTFAS 1539
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 1540 ---SMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
Query: 957 NLLVAILVEGFQ-AEGDANKSESEPDF 982
N+ +A+++E F A ++ E DF
Sbjct: 1597 NMYIAVILENFNTATEESEDPLGEDDF 1623
Score = 90.9 bits (224), Expect = 1e-17
Identities = 65/278 (23%), Positives = 131/278 (47%), Gaps = 41/278 (14%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
Query: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
Query: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
Query: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
Query: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
+S +YF+ + FG++ NL + ++++ F +
Sbjct: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
Score = 88.6 bits (218), Expect = 6e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
Query: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
Query: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1671
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
Query: 1672 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
Query: 1732 ------------------------------------------GDLECDETHPCEGLG--- 1746
G+ C + C+
Sbjct: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
Query: 1747 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
Query: 1805 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1844
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
Score = 86.7 bits (213), Expect = 2e-16
Identities = 67/298 (22%), Positives = 138/298 (46%), Gaps = 28/298 (9%)
Query: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
Query: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
Query: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
Query: 1429 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1488
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
Query: 1489 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS 1546
++ FI +I VLN+F+ +++ +F + E R+ K L++ RR+
Sbjct: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSN-EERNGNLEGEARKTKVQLALDRFRRA 842
Score = 85.5 bits (210), Expect = 5e-16
Identities = 56/260 (21%), Positives = 117/260 (45%), Gaps = 52/260 (20%)
Query: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
Query: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
Query: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
CK S + + P+ K
Sbjct: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
Query: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
Query: 960 VAILVEGFQAEGDANKSESE 979
+A++ ++ + +E E
Sbjct: 396 LAVVTMAYEEQNKNVAAEIE 415
Score = 71.2 bits (173), Expect = 1e-11
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
Score = 51.6 bits (122), Expect = 8e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
Query: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
Score = 33.9 bits (76), Expect = 1.8
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
Query: 399 SETKQRESQLMREQR 413
S ++R L E R
Sbjct: 815 S-NEERNGNLEGEAR 828
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 336 bits (861), Expect = 2e-91
Identities = 205/666 (30%), Positives = 360/666 (54%), Gaps = 53/666 (7%)
Query: 1193 DPPLDGDDADDEGNLSKGERVRAWIR----ARLPACCLERDSWSAYIFPPQSRFRLLCHR 1248
D PL G+ + E + A R C + +S I+ R C++
Sbjct: 1120 DNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIW---WNIRKTCYK 1176
Query: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
I+ H F+ ++++I L+ +A E I+ +I L ++ IFT +F+ EM +K +A
Sbjct: 1177 IVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA 1236
Query: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
G+ + Y ++W LD L+V +S++ ++ + + G LG ++ LR LR LRPLR
Sbjct: 1237 YGY----KTYFTNAWCWLDFLIVDVSLVTLVANTL---GYSDLGPIKSLRTLRALRPLRA 1289
Query: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED------ 1422
+SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF+ C
Sbjct: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFP 1349
Query: 1423 TRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
+ N+S+C + RW K NFDN+G +SL +A+ GW IMY +D+V
Sbjct: 1350 ASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVN 1409
Query: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1536
VD+QP ++ +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1410 VDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKK 1469
Query: 1537 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
KK SK+ Q KP ++ + + L T+ D+ I +I LN+VTM +
Sbjct: 1470 YYNAMKKLGSKKPQ------KPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523
Query: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
E Q Q + E L N +F ++F E V KL++ +F WN D +V++SI+G+
Sbjct: 1524 EKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVIISIVGM 1582
Query: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
L ++ + ++PT+ R++R+ RI R+L+L+K A G+R LL +M +LP + N+GLL
Sbjct: 1583 FLADL--IETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLL 1640
Query: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
L+ FI+A G+ F ++ + +G+ F FG + + LF+++T W+G++
Sbjct: 1641 FLVMFIYAIFGMSNFAYVKKE-----DGINDMFNFETFGNSMICLFQITTSAGWDGLLAP 1695
Query: 1777 TLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEES 1823
L DCD E C N + YFVS+++ + V+VN+ IAV++++ +
Sbjct: 1696 ILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVA 1755
Query: 1824 NKEAKE 1829
+E+ E
Sbjct: 1756 TEESTE 1761
Score = 156 bits (395), Expect = 2e-37
Identities = 204/914 (22%), Positives = 370/914 (40%), Gaps = 208/914 (22%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV- 796
KI+ F IM IL N + M + P + T +E + FT ++ E L+K+L
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMN---NPPDWTKNVEYT---FTGIYTFESLVKILAR 174
Query: 797 ---YGPFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
G F ++++P+N D V++V + + E V G +S LRTFR++R LK + +P L+
Sbjct: 175 GFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLK 232
Query: 853 RQLVVLMKTMDNVA------TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKN- 905
+ L++++ ++ FC+ + I + +G C S + +TL N
Sbjct: 233 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNT 292
Query: 906 ---------------------------------------------------FDSLLWAIV 914
FD+ WA +
Sbjct: 293 LESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFL 352
Query: 915 TVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDAN 974
+F+++TQ+ W + + + ++F+ ++ G++ L NL++A++ ++ + AN
Sbjct: 353 ALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412
Query: 975 KSESEPDF--FSPSLDG---DGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPK 1029
E++ F LD + + + +A + E+ +R+S + L ++ T K
Sbjct: 413 IEEAKQKELEFQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGLSESSSETSKLSSK 471
Query: 1030 STST-------------GLGEALGPASRRTSSSG-------SAEPGAAHEMKSPPSARSS 1069
S GE G A + + S S G ++ S+
Sbjct: 472 SAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLST 531
Query: 1070 PH-SPWSAASS-WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1127
P+ SP S S +++RRSSR SL G G++ E E +++E
Sbjct: 532 PNQSPLSIRGSLFSARRSSRTSLFS----------------FKGRGRDIGSETEFADDEH 575
Query: 1128 ASPAGSDHRHRGSL----EREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNG--KSA 1181
S G + RGSL + + S ++ + P + G DCNG
Sbjct: 576 -SIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPV---NGKMHSAVDCNGVVSLV 631
Query: 1182 SGRLARAL-----------------RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPAC 1224
GR A L R L +D ++ NL R RA RA +
Sbjct: 632 DGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNL----RQRAMSRASILTN 687
Query: 1225 CLERDSWSAYIFPPQ-----------------SRFRLLCHRIITHKMFDHVVLVIIFLNC 1267
+E S PP +F+ + I+ D + + I LN
Sbjct: 688 TVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNT 747
Query: 1268 ITIAMERPKIDPHSAE-RIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326
+ +AME P + E + L + N +FT +F AEM +K++A+ Y + WN+
Sbjct: 748 LFMAMEH---HPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD----PYEYFQVGWNIF 800
Query: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386
D L+V +S++++ ++ V L VLR R LR ++ L ++++ + +S+
Sbjct: 801 DSLIVTLSLVELFLADVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 852
Query: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFF---VCQGEDTRNITNKSDCAEASYRWVRHK 1443
+GN+ ++ IF ++G+QLF GK + VC+ D DC RW H
Sbjct: 853 GALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIND--------DCTLP--RW--HM 899
Query: 1444 YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAF 1503
+F + L+ VL + W++ M+D ++ G L+ ++ ++I
Sbjct: 900 NDFFH--SFLIVFRVLCGE--WIETMWDCMEVAG---------QAMCLIVYMMVMVIGNL 946
Query: 1504 FVLNMFVGVVVENF 1517
VLN+F+ +++ +F
Sbjct: 947 VVLNLFLALLLSSF 960
Score = 144 bits (364), Expect = 7e-34
Identities = 84/248 (33%), Positives = 141/248 (56%), Gaps = 8/248 (3%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + I I I++NTL M +E+H EE N L I N+VFT +FA EM+LKL+
Sbjct: 729 IVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD 788
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVL 858
P+ Y + +NIFD +IV +S+ E+ GLSVLR+FRL+RV KL + P L + ++
Sbjct: 789 PYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKII 848
Query: 859 MKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRKNFDSLLWAIV 914
++ + ++L + +FIF+++GM LFG + D TLP R + + + +
Sbjct: 849 GNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RWHMNDFFHSFL 907
Query: 915 TVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDA 973
VF++L E W + +++ M + + + ++ +M GN V+ NL +A+L+ F ++ +
Sbjct: 908 IVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD-NL 965
Query: 974 NKSESEPD 981
E +PD
Sbjct: 966 TAIEEDPD 973
Score = 140 bits (352), Expect = 2e-32
Identities = 114/378 (30%), Positives = 177/378 (46%), Gaps = 92/378 (24%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128
R C + V + WFE +L+ILL+ L EDI + ++ +I+ + D IF + F
Sbjct: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAF----EDIYIERKKTIKIILEYADKIFTYIF 1226
Query: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181
+EM++K +A +G K Y + W LDF IV +A L YS DL + ++RT
Sbjct: 1227 ILEMLLKWIA---YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYS-DLGPIK--SLRT 1280
Query: 182 VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG
Sbjct: 1281 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG------ 1334
Query: 242 FLPENFSLPLSVDLERYYQTEN-EDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
++Y+ N D S F SQ P
Sbjct: 1335 ---------------KFYECINTTDGSRFPASQV---------------------PNRSE 1358
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+ N S N V W +NFDN+G ++++ QV T +GW IM
Sbjct: 1359 CFALMNVSQN---VRWKNL--------------KVNFDNVGLGYLSLLQVATFKGWTIIM 1401
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ +S Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1402 YAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1461
Query: 408 LMREQRVRFLSNASTLAS 425
M E++ ++ + L S
Sbjct: 1462 FMTEEQKKYYNAMKKLGS 1479
Score = 130 bits (326), Expect = 2e-29
Identities = 112/480 (23%), Positives = 202/480 (42%), Gaps = 62/480 (12%)
Query: 57 APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116
A + LS S R ++ + + F + M IL NC+ + M P +
Sbjct: 102 ATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPD----------W 151
Query: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175
+ + + E +VK++A G G+ +L D WN LDF +++ L ++L NVS
Sbjct: 152 TKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVS 211
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+RT RVLR L+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G
Sbjct: 212 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
L+++CF + + ++E + F + ++ +
Sbjct: 270 NLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALL--------------- 314
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
CG ++ TCV + NP G +FD +A++A+F+++T +
Sbjct: 315 --CGFSTDSGQCPEGYTCVKIGR----------NPDYGYTSFDTFSWAFLALFRLMTQDY 362
Query: 356 WVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVR 415
W ++ + A I+F+++I +GSF++INL L V+A + E Q + +++ +
Sbjct: 363 WENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELE 422
Query: 416 FLSNASTLASFSEPGSC-------YEELLKYLVYILRKAARRLAQVS---------RAAG 459
F L E Y + + + L +++ +++S R
Sbjct: 423 FQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKK 482
Query: 460 VRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASP 519
LSS G E S S RR S H V H H L P SP
Sbjct: 483 KNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEK------RLSTPNQSP 536
Score = 121 bits (304), Expect = 7e-27
Identities = 91/379 (24%), Positives = 168/379 (44%), Gaps = 72/379 (18%)
Query: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Y+ P S R + +I+ H +F +++ I NCI + M P + E Y
Sbjct: 107 YMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVE--------YT 158
Query: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
FT ++ E VK++A G+C GE +LR WN LD ++++ + + V+ LG
Sbjct: 159 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---------LGN 209
Query: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
+ LR R LR L+ IS GLK +V L+ S+K + +++++ +F ++G+QLF G
Sbjct: 210 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269
Query: 1414 K--------------------------------FFVCQGEDTRNI----TNKSDCAEASY 1437
F+ +G + T+ C E Y
Sbjct: 270 NLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPE-GY 328
Query: 1438 RWVRHKYN-------FDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWM 1490
V+ N FD A ++LF L ++D W ++ L A G
Sbjct: 329 TCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG----------KTY 378
Query: 1491 LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQ 1550
+++F+ + + +F+++N+ + VV + + Q EEA+++E + + L++ ++ +E+
Sbjct: 379 MIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQEEA 437
Query: 1551 MAEAQCKPYYSDYSRFRLL 1569
A A Y+ R R++
Sbjct: 438 EAIAAAAAEYTSIRRSRIM 456
Score = 114 bits (284), Expect = 1e-24
Identities = 82/279 (29%), Positives = 137/279 (49%), Gaps = 27/279 (9%)
Query: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
C PY+ +F+ ++ + ++DL IT I LN + MAMEH+ + L I N +
Sbjct: 715 CSPYWI---KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLV 771
Query: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
FT IF E V KL+A +FQ WN D IV LS++ + L ++E +
Sbjct: 772 FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG----------LS 821
Query: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732
++R R+ RV KL K + L+ + ++ +GNL L+ ++ FIFA +G++LFG
Sbjct: 822 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 881
Query: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791
+ C C H +F +FL +FRV G+ W +T+ DC + +
Sbjct: 882 KECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQA 931
Query: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830
+ I ++ ++ V++N+ +A+L+ N A EE
Sbjct: 932 MCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE 970
Score = 101 bits (251), Expect = 9e-21
Identities = 84/344 (24%), Positives = 154/344 (44%), Gaps = 46/344 (13%)
Query: 672 RAGAGEVELADREMPDSDSEAVYE-FTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWR 730
R+ + E D +P EA E D + D RR + E +W
Sbjct: 1110 RSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWN 1169
Query: 731 LICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFAL 788
I T KIV+ +F I++ IL+++ ++ E Y E+ + + LE ++ +FT +F L
Sbjct: 1170 -IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFIL 1228
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG--GLSVLRTFRLMRVLKLVR 846
EMLLK + YG Y N + D +IV +S+ +V G L +++ R +R L+ +R
Sbjct: 1229 EMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLR 1288
Query: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGDTL 900
L + VV L+ + ++ ++ ++F IFSI+G++LF KF + DG
Sbjct: 1289 ALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRF 1348
Query: 901 PD------------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST 936
P + NFD++ +++ Q+ T + W ++Y + S
Sbjct: 1349 PASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSV 1408
Query: 937 ----------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
S + +YF+ + FG++ NL + ++++ F +
Sbjct: 1409 NVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452
Score = 94.4 bits (233), Expect = 1e-18
Identities = 77/277 (27%), Positives = 130/277 (46%), Gaps = 41/277 (14%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V ++ F IM+ I +N ++M +E Q + +T L N+VF LF E +LKL+
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847
+ Y +NIFD V+V+IS IVG L V+R R+ R+L+LV+
Sbjct: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
Query: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907
++ L LM ++ + +LL L +FI++I GM FA + D + D NF+
Sbjct: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEDGINDMFNFE 1671
Query: 908 SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946
+ +++ +FQI T W+ +L G S YF++
Sbjct: 1672 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVS 1731
Query: 947 LMTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
+ V+ N+ +A+++E F A ++ + SE DF
Sbjct: 1732 YIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDF 1768
Score = 87.8 bits (216), Expect = 1e-16
Identities = 80/335 (23%), Positives = 140/335 (41%), Gaps = 92/335 (27%)
Query: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
++LVH L + I I N + M M + + K Y FT I+ ES+
Sbjct: 121 KILVHSL-----FSMLIMCTILTNCIFMTMNNPP------DWTKNVEYTFTGIYTFESLV 169
Query: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
K++A GF F +D WN LD +++ + L E +N + +R R+
Sbjct: 170 KILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALRTFRV 218
Query: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL------- 1734
R LK + + G++ ++ ++Q++ ++ ++ +L + +FA +G++LF G+L
Sbjct: 219 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278
Query: 1735 --------------------------------------------ECDETHPCEGLGR--- 1747
+C E + C +GR
Sbjct: 279 SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338
Query: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
+ +F F AFL LFR+ T D W + + TLR + I+FV +
Sbjct: 339 YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM--------IFFVVVIFLGS 390
Query: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELE 1840
F L+N+++AV+ EE N+ EEA+ + ELE +
Sbjct: 391 FYLINLILAVVAMAYEEQNQANIEEAK-QKELEFQ 424
Score = 59.7 bits (143), Expect = 3e-08
Identities = 46/177 (25%), Positives = 93/177 (52%), Gaps = 15/177 (8%)
Query: 78 VCNPWFERISMLVILLNCVTLGM-FRPCEDIACDSQRCRILQAFDDFIFA-FFAVEMVVK 135
V +P+ + + I+LN + + M P ++ + + A + +F FA EMV+K
Sbjct: 730 VMDPFVDLAITICIVLNTLFMAMEHHPM------TEEFKNVLAIGNLVFTGIFAAEMVLK 783
Query: 136 MVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRTVRVLRPLRAINRV 194
++A+ + Y WN D IV ++E L D++ +S +R+ R+LR +
Sbjct: 784 LIAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVEGLS--VLRSFRLLRVFKLAKSW 838
Query: 195 PSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250
P++ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+ + C + ++ +LP
Sbjct: 839 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 895
Score = 55.8 bits (133), Expect = 4e-07
Identities = 46/164 (28%), Positives = 73/164 (44%), Gaps = 15/164 (9%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V N F+ M++I LN VT+ + E +L + F E V+K++
Sbjct: 1501 VTNQAFDISIMVLICLNMVTMMV----EKEGQSQHMTEVLYWINVVFIILFTGECVLKLI 1556
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRA 190
+L + Y WN DF +VI ++ L + F +R R+ R LR
Sbjct: 1557 SL----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRL 1612
Query: 191 INRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+ +R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1613 VKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
Score = 33.9 bits (76), Expect = 1.8
Identities = 19/97 (19%), Positives = 40/97 (41%), Gaps = 21/97 (21%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374
NF+ G + I +FQ+ T GW ++ ++++ + Y
Sbjct: 1669 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFY 1728
Query: 375 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411
F+ II+ ++N+ + VI FS + ++ + E
Sbjct: 1729 FVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 335 bits (858), Expect = 4e-91
Identities = 227/784 (28%), Positives = 410/784 (52%), Gaps = 67/784 (8%)
Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
++EEE E ++ + S + + +E+ A + +++ + TA G + +
Sbjct: 767 KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823
Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
+ + ++ P+ P G++ ++E + G R R L + SA+ I
Sbjct: 824 DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
F +RFRL CHRI+ +F +++L I L+ I++A E P + S L ++Y+FT
Sbjct: 883 FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941
Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
++F E+ +K+ A G + ++ R+ +N+LD L+V +S+I + + + +++
Sbjct: 942 SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
+LR+LR LRPLR I+RA+GLK VV+ + +++ IGNIV++ +F +GVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
+ C + IT K + W K++FDN+ A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
GW +++Y +D+ D+ PI N+ + ++FI +++I+AFF++N+FVG V+ F Q
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171
Query: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Q E+E + E L+K +R + +A+ Y ++ + V ++ S Y + +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLM 1225
Query: 1584 TGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQ 1643
+I LN + +AM+HY Q + A+ I N +FT +F +E + KL+AF + +F D WN
Sbjct: 1226 FVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNT 1285
Query: 1644 LDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVM 1703
D IV+ SI+ I + EVN + + I R+ R+ R++KLL G+R LL T +
Sbjct: 1286 FDALIVVGSIVDIAI--TEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1343
Query: 1704 QALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFR 1763
++ + + LL ++LFFI+A +G+++FG + ++T + R+ F+ F A L LFR
Sbjct: 1344 KSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQTFPQAVLLLFR 1400
Query: 1764 VSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFVLTAQFVLVNVV 1812
+TG+ W IM + + C ES N+ + YF+SF + F+++N+
Sbjct: 1401 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1460
Query: 1813 IAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTLSPQPHSPLGSP 1855
+AV+M HL+E + A+ + E + ++ L++ TL + PLG
Sbjct: 1461 VAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1520
Query: 1856 FLWP 1859
L P
Sbjct: 1521 KLCP 1524
Score = 241 bits (616), Expect = 4e-63
Identities = 181/698 (25%), Positives = 327/698 (46%), Gaps = 109/698 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
R C I+ K F+ ++L+ IF NC+ +A+ P D +A L Y+F +F E
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173
Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
+KV+A G F AYLR+ WN+LD ++V++ + ++ + + G LG +
Sbjct: 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233
Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
+ LR R LRPLR++S L++V+ +++ ++ P+ +I ++ II+ I+G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
C + D + S CA + W K+ NFDN A+
Sbjct: 294 MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353
Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
+++F + +GW D++Y DAVG D W +YF++ ++I +FFVLN+ +GV+
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404
Query: 1514 VE-------------NFHKCRQHQE--------------------EEEARRREEKRLRRL 1540
+F K R+ Q+ E E +E++ R +
Sbjct: 405 SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464
Query: 1541 EKKRRSKEK----------------------QMAEAQCKPYYSDYSRF-RLLVHHLCTSH 1577
E ++++++ Y+ ++RF R S+
Sbjct: 465 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ ++ LN +T+A EHY QP L E N +F E + K+ + G + +F
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
+N+ D +V I+ L E ++ ++P I ++R +R+ R+ K+ + +
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1756
L+ +++ ++ + +L LL L IF+ LG++LF G DE R +TF NF
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694
Query: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
+ LT+F++ TG++WN +M D + S + ++ IYF+ + ++L+NV +A+
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752
Query: 1817 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
+ +L ES A++E E E E + +T SP+ L
Sbjct: 753 VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790
Score = 148 bits (374), Expect = 5e-35
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C+ V FE I +L I NCV L ++ P + ++ L+ + F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
E +K++A G+ F YL + WN LDF IV+ G+ L+ +
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+R RVLRPLR ++ VPS+++++ ++ + L ++ LL FV I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
+ C+ E I P E+ C + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
C Q T C G P G NFDN +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
W D++Y+V DA + +IYF+ LII+GSFF++NL L V++ +FS+ +++ + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424
Query: 410 REQR 413
RE++
Sbjct: 425 REKQ 428
Score = 147 bits (370), Expect = 1e-34
Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)
Query: 674 GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
G E + + MP S++E+V T++ D+ + + L S +WR
Sbjct: 455 GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510
Query: 732 -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
C R V S F ++ + +NTL++ E++ QP LT + +N +LF E
Sbjct: 511 RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570
Query: 790 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
MLLK+ G Y + +N FD +V + E + + G+SVLR RL+R+ K+
Sbjct: 571 MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM LFG KF + + R
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
FD+ +++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+
Sbjct: 688 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 959 LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
+AI V+ ++ E + + +RKK S PE ++ L+ P +
Sbjct: 748 FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796
Query: 1018 IHTAATPMSLPKSTSTG 1034
+ + L T+ G
Sbjct: 797 GESKEEKIELKSITADG 813
Score = 119 bits (297), Expect = 4e-26
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 51/319 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAVF 1298
R C + +F +V+ ++FLN +TIA E H + +LT +N A+F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASE------HYNQPNWLTEVQDTANKALLALF 567
Query: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID-ILVSMVSDSGTKILGML--R 1355
AEM +K+ +LG QAY S +N D +V +++ ILV TKI+ L
Sbjct: 568 TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVE------TKIMSPLGIS 617
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
VLR +R LR ++ L +V +L++S++ I +++++ F IIF +LG+QLF GKF
Sbjct: 618 VLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF 677
Query: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
+ + R+ FDN Q+L+++F + + + W +MYDG+ A
Sbjct: 678 NFDEMQTRRS-------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGIMA 718
Query: 1476 VGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCR-----QHQEEEEAR 1530
G P M + +YFI + + +LN+F+ + V+N Q +EEEE
Sbjct: 719 YGGPSFPGM----LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774
Query: 1531 RREEKRLRRLEKKRRSKEK 1549
R++ R EKK+ EK
Sbjct: 775 RKKLARTASPEKKQELVEK 793
Score = 110 bits (276), Expect = 1e-23
Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
+ +P P + FF S ++R R C R V + F + + ILL+ ++L P +
Sbjct: 870 KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
S R IL D + F +E+++KM A G F K + + +N LD +V ++ +
Sbjct: 927 --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984
Query: 168 SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
+ ++ + R +RVLRPLRAINR ++ +V + + +GN++++ + F+F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 227 IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
+GVQL+ G L + + S + + Y T + E QPR
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089
Query: 287 TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
+W E++ F +FDN+ A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107
Query: 347 IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
+F V T EGW +++Y +D+H+ YN+ I+FI+ II+ +FFM+N+ + +
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 397 QFSETKQRE 405
F E ++E
Sbjct: 1168 TFQEQGEQE 1176
Score = 108 bits (271), Expect = 4e-23
Identities = 70/256 (27%), Positives = 132/256 (51%), Gaps = 29/256 (11%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V+S YF + + IL+NT+ + ++++ Q A+ I N++FT LF +EM+LKL+ +
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIV------GQQGGGLSV--LRTFRLMRVLKLVRFLPA 850
P Y + +N FD +IVV S+ +I ++ +S+ R FR+MR++KL+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L +K+ + +L+++ FI++++GM +FG K A D + NF +
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTEINRNNNFQTFP 1392
Query: 911 WAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFG 951
A++ +F+ T E W ++ M SS+A YFI+
Sbjct: 1393 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLC 1452
Query: 952 NYVLFNLLVAILVEGF 967
+++ NL VA++++ F
Sbjct: 1453 AFLIINLFVAVIMDNF 1468
Score = 105 bits (261), Expect = 6e-22
Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ I Y PE+ +NA LE +F +F +E LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178
Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
+ YG P Y++N +N+ D +IVV+ ++ + G +G G V LR
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238
Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
FR++R L+LV +P+LQ L ++K M + +L++ I I++I+G+ LF K
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298
Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
+ D P NFD+ +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358
Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
+T E W VLY A W +YF+ L+ G++ + NL++ +L F E + K+
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query: 978 SE 979
+
Sbjct: 419 GD 420
Score = 90.9 bits (224), Expect = 1e-17
Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)
Query: 595 TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
TS E +EK ++A ++ P L P S + +E +S G + KI+
Sbjct: 763 TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
L+ + D PY GE + + EMP + L + H +
Sbjct: 823 MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868
Query: 712 RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
+ P+A + + +RL C +IV+ F I+ IL++++S+ E Q
Sbjct: 869 EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 769 EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
N L ++ VFTS+F LE++LK+ YG F + +N +NI D ++V +S+
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984
Query: 824 GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
G Q ++V++ R++RVL+ +R L + + + V ++T+ N+ LL F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041
Query: 878 IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
+F+ +G+ LF CK + + +DG+ + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101
Query: 910 LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
L A++ +F + T E W ++LY + S + +++FI + + + N+
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161
Query: 960 VAILVEGFQAEGDANKSESEPD 981
V ++ FQ +G+ E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183
Score = 65.9 bits (159), Expect = 4e-10
Identities = 47/172 (27%), Positives = 83/172 (48%), Gaps = 20/172 (11%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V + +FE + ++ILLN + L M Q C A + F F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN-------VSFSAVRTVRVLRP 187
K++A F K Y D WN D IV+ +++ ++ N +S + R RV+R
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
++ ++R +R L+ + + L V LL +FFI+ ++G+Q++ + N
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C V + F + + ++ LN +T+ E + + + + A F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
EM++KM +LG+ + Y +NR D F+V G+LE L + + S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
L + ++ + S E+ + + AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 335 bits (858), Expect = 4e-91
Identities = 227/784 (28%), Positives = 410/784 (52%), Gaps = 67/784 (8%)
Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
++EEE E ++ + S + + +E+ A + +++ + TA G + +
Sbjct: 767 KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823
Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
+ + ++ P+ P G++ ++E + G R R L + SA+ I
Sbjct: 824 DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
F +RFRL CHRI+ +F +++L I L+ I++A E P + S L ++Y+FT
Sbjct: 883 FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941
Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
++F E+ +K+ A G + ++ R+ +N+LD L+V +S+I + + + +++
Sbjct: 942 SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
+LR+LR LRPLR I+RA+GLK VV+ + +++ IGNIV++ +F +GVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
+ C + IT K + W K++FDN+ A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
GW +++Y +D+ D+ PI N+ + ++FI +++I+AFF++N+FVG V+ F Q
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171
Query: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Q E+E + E L+K +R + +A+ Y ++ + V ++ S Y + +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLM 1225
Query: 1584 TGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQ 1643
+I LN + +AM+HY Q + A+ I N +FT +F +E + KL+AF + +F D WN
Sbjct: 1226 FVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNT 1285
Query: 1644 LDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVM 1703
D IV+ SI+ I + EVN + + I R+ R+ R++KLL G+R LL T +
Sbjct: 1286 FDALIVVGSIVDIAI--TEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1343
Query: 1704 QALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFR 1763
++ + + LL ++LFFI+A +G+++FG + ++T + R+ F+ F A L LFR
Sbjct: 1344 KSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQTFPQAVLLLFR 1400
Query: 1764 VSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFVLTAQFVLVNVV 1812
+TG+ W IM + + C ES N+ + YF+SF + F+++N+
Sbjct: 1401 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1460
Query: 1813 IAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTLSPQPHSPLGSP 1855
+AV+M HL+E + A+ + E + ++ L++ TL + PLG
Sbjct: 1461 VAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1520
Query: 1856 FLWP 1859
L P
Sbjct: 1521 KLCP 1524
Score = 241 bits (616), Expect = 4e-63
Identities = 181/698 (25%), Positives = 327/698 (46%), Gaps = 109/698 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
R C I+ K F+ ++L+ IF NC+ +A+ P D +A L Y+F +F E
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173
Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
+KV+A G F AYLR+ WN+LD ++V++ + ++ + + G LG +
Sbjct: 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233
Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
+ LR R LRPLR++S L++V+ +++ ++ P+ +I ++ II+ I+G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
C + D + S CA + W K+ NFDN A+
Sbjct: 294 MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353
Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
+++F + +GW D++Y DAVG D W +YF++ ++I +FFVLN+ +GV+
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404
Query: 1514 VE-------------NFHKCRQHQE--------------------EEEARRREEKRLRRL 1540
+F K R+ Q+ E E +E++ R +
Sbjct: 405 SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464
Query: 1541 EKKRRSKEK----------------------QMAEAQCKPYYSDYSRF-RLLVHHLCTSH 1577
E ++++++ Y+ ++RF R S+
Sbjct: 465 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ ++ LN +T+A EHY QP L E N +F E + K+ + G + +F
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
+N+ D +V I+ L E ++ ++P I ++R +R+ R+ K+ + +
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1756
L+ +++ ++ + +L LL L IF+ LG++LF G DE R +TF NF
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694
Query: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
+ LT+F++ TG++WN +M D + S + ++ IYF+ + ++L+NV +A+
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752
Query: 1817 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
+ +L ES A++E E E E + +T SP+ L
Sbjct: 753 VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790
Score = 148 bits (374), Expect = 5e-35
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C+ V FE I +L I NCV L ++ P + ++ L+ + F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
E +K++A G+ F YL + WN LDF IV+ G+ L+ +
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+R RVLRPLR ++ VPS+++++ ++ + L ++ LL FV I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
+ C+ E I P E+ C + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
C Q T C G P G NFDN +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
W D++Y+V DA + +IYF+ LII+GSFF++NL L V++ +FS+ +++ + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424
Query: 410 REQR 413
RE++
Sbjct: 425 REKQ 428
Score = 147 bits (370), Expect = 1e-34
Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)
Query: 674 GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
G E + + MP S++E+V T++ D+ + + L S +WR
Sbjct: 455 GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510
Query: 732 -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
C R V S F ++ + +NTL++ E++ QP LT + +N +LF E
Sbjct: 511 RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570
Query: 790 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
MLLK+ G Y + +N FD +V + E + + G+SVLR RL+R+ K+
Sbjct: 571 MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM LFG KF + + R
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
FD+ +++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+
Sbjct: 688 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 959 LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
+AI V+ ++ E + + +RKK S PE ++ L+ P +
Sbjct: 748 FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796
Query: 1018 IHTAATPMSLPKSTSTG 1034
+ + L T+ G
Sbjct: 797 GESKEEKIELKSITADG 813
Score = 119 bits (297), Expect = 4e-26
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 51/319 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAVF 1298
R C + +F +V+ ++FLN +TIA E H + +LT +N A+F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASE------HYNQPNWLTEVQDTANKALLALF 567
Query: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID-ILVSMVSDSGTKILGML--R 1355
AEM +K+ +LG QAY S +N D +V +++ ILV TKI+ L
Sbjct: 568 TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVE------TKIMSPLGIS 617
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
VLR +R LR ++ L +V +L++S++ I +++++ F IIF +LG+QLF GKF
Sbjct: 618 VLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF 677
Query: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
+ + R+ FDN Q+L+++F + + + W +MYDG+ A
Sbjct: 678 NFDEMQTRRS-------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGIMA 718
Query: 1476 VGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCR-----QHQEEEEAR 1530
G P M + +YFI + + +LN+F+ + V+N Q +EEEE
Sbjct: 719 YGGPSFPGM----LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774
Query: 1531 RREEKRLRRLEKKRRSKEK 1549
R++ R EKK+ EK
Sbjct: 775 RKKLARTASPEKKQELVEK 793
Score = 110 bits (276), Expect = 1e-23
Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
+ +P P + FF S ++R R C R V + F + + ILL+ ++L P +
Sbjct: 870 KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
S R IL D + F +E+++KM A G F K + + +N LD +V ++ +
Sbjct: 927 --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984
Query: 168 SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
+ ++ + R +RVLRPLRAINR ++ +V + + +GN++++ + F+F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 227 IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
+GVQL+ G L + + S + + Y T + E QPR
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089
Query: 287 TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
+W E++ F +FDN+ A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107
Query: 347 IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
+F V T EGW +++Y +D+H+ YN+ I+FI+ II+ +FFM+N+ + +
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 397 QFSETKQRE 405
F E ++E
Sbjct: 1168 TFQEQGEQE 1176
Score = 108 bits (271), Expect = 4e-23
Identities = 70/256 (27%), Positives = 132/256 (51%), Gaps = 29/256 (11%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V+S YF + + IL+NT+ + ++++ Q A+ I N++FT LF +EM+LKL+ +
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIV------GQQGGGLSV--LRTFRLMRVLKLVRFLPA 850
P Y + +N FD +IVV S+ +I ++ +S+ R FR+MR++KL+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L +K+ + +L+++ FI++++GM +FG K A D + NF +
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTEINRNNNFQTFP 1392
Query: 911 WAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFG 951
A++ +F+ T E W ++ M SS+A YFI+
Sbjct: 1393 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLC 1452
Query: 952 NYVLFNLLVAILVEGF 967
+++ NL VA++++ F
Sbjct: 1453 AFLIINLFVAVIMDNF 1468
Score = 105 bits (261), Expect = 6e-22
Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ I Y PE+ +NA LE +F +F +E LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178
Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
+ YG P Y++N +N+ D +IVV+ ++ + G +G G V LR
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238
Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
FR++R L+LV +P+LQ L ++K M + +L++ I I++I+G+ LF K
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298
Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
+ D P NFD+ +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358
Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
+T E W VLY A W +YF+ L+ G++ + NL++ +L F E + K+
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query: 978 SE 979
+
Sbjct: 419 GD 420
Score = 90.9 bits (224), Expect = 1e-17
Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)
Query: 595 TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
TS E +EK ++A ++ P L P S + +E +S G + KI+
Sbjct: 763 TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
L+ + D PY GE + + EMP + L + H +
Sbjct: 823 MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868
Query: 712 RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
+ P+A + + +RL C +IV+ F I+ IL++++S+ E Q
Sbjct: 869 EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 769 EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
N L ++ VFTS+F LE++LK+ YG F + +N +NI D ++V +S+
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984
Query: 824 GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
G Q ++V++ R++RVL+ +R L + + + V ++T+ N+ LL F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041
Query: 878 IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
+F+ +G+ LF CK + + +DG+ + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101
Query: 910 LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
L A++ +F + T E W ++LY + S + +++FI + + + N+
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161
Query: 960 VAILVEGFQAEGDANKSESEPD 981
V ++ FQ +G+ E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183
Score = 65.9 bits (159), Expect = 4e-10
Identities = 47/172 (27%), Positives = 83/172 (48%), Gaps = 20/172 (11%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V + +FE + ++ILLN + L M Q C A + F F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN-------VSFSAVRTVRVLRP 187
K++A F K Y D WN D IV+ +++ ++ N +S + R RV+R
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
++ ++R +R L+ + + L V LL +FFI+ ++G+Q++ + N
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C V + F + + ++ LN +T+ E + + + + A F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
EM++KM +LG+ + Y +NR D F+V G+LE L + + S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
L + ++ + S E+ + + AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 334 bits (857), Expect = 5e-91
Identities = 226/793 (28%), Positives = 411/793 (51%), Gaps = 74/793 (9%)
Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
++EEE E ++ + S + + +E+ A + +++ + TA G + +
Sbjct: 767 KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823
Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
+ + ++ P+ P G++ ++E + G R R L + SA+ I
Sbjct: 824 DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
F +RFRL CHRI+ +F +++L I L+ I++A E P + S L ++Y+FT
Sbjct: 883 FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941
Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
++F E+ +K+ A G + ++ R+ +N+LD L+V +S+I + + + +++
Sbjct: 942 SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
+LR+LR LRPLR I+RA+GLK VV+ + +++ IGNIV++ +F +GVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
+ C + IT K + W K++FDN+ A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
GW +++Y +D+ D+ PI N+ + ++FI +++I+AFF++N+FVG V+ F Q
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171
Query: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Q E+E + E L+K +R + +A+ Y ++ + V ++ S Y + +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLM 1225
Query: 1584 TGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQ 1643
+I LN + +AM+HY Q + A+ I N +FT +F +E + KL+AF + +F D WN
Sbjct: 1226 FVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNT 1285
Query: 1644 LDLAIVLLSIMGITLEEIEVNASLPINPTI---------IRIMRVLRIARVLKLLKMAVG 1694
D IV+ SI+ I + E+ +P++ I R+ R+ R++KLL G
Sbjct: 1286 FDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEG 1345
Query: 1695 MRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNF 1754
+R LL T +++ + + LL ++LFFI+A +G+++FG + ++T + R+ F+ F
Sbjct: 1346 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQTF 1402
Query: 1755 GMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFVLT 1803
A L LFR +TG+ W IM + + C ES N+ + YF+SF +
Sbjct: 1403 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1462
Query: 1804 AQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTLSP 1846
F+++N+ +AV+M HL+E + A+ + E + ++ L++ TL
Sbjct: 1463 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLR 1522
Query: 1847 QPHSPLGSPFLWP 1859
+ PLG L P
Sbjct: 1523 RIQPPLGFGKLCP 1535
Score = 241 bits (616), Expect = 4e-63
Identities = 181/698 (25%), Positives = 327/698 (46%), Gaps = 109/698 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
R C I+ K F+ ++L+ IF NC+ +A+ P D +A L Y+F +F E
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173
Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
+KV+A G F AYLR+ WN+LD ++V++ + ++ + + G LG +
Sbjct: 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233
Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
+ LR R LRPLR++S L++V+ +++ ++ P+ +I ++ II+ I+G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
C + D + S CA + W K+ NFDN A+
Sbjct: 294 MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353
Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
+++F + +GW D++Y DAVG D W +YF++ ++I +FFVLN+ +GV+
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404
Query: 1514 VE-------------NFHKCRQHQE--------------------EEEARRREEKRLRRL 1540
+F K R+ Q+ E E +E++ R +
Sbjct: 405 SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464
Query: 1541 EKKRRSKEK----------------------QMAEAQCKPYYSDYSRF-RLLVHHLCTSH 1577
E ++++++ Y+ ++RF R S+
Sbjct: 465 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ ++ LN +T+A EHY QP L E N +F E + K+ + G + +F
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
+N+ D +V I+ L E ++ ++P I ++R +R+ R+ K+ + +
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1756
L+ +++ ++ + +L LL L IF+ LG++LF G DE R +TF NF
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694
Query: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
+ LT+F++ TG++WN +M D + S + ++ IYF+ + ++L+NV +A+
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752
Query: 1817 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
+ +L ES A++E E E E + +T SP+ L
Sbjct: 753 VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790
Score = 148 bits (374), Expect = 5e-35
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C+ V FE I +L I NCV L ++ P + ++ L+ + F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
E +K++A G+ F YL + WN LDF IV+ G+ L+ +
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+R RVLRPLR ++ VPS+++++ ++ + L ++ LL FV I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
+ C+ E I P E+ C + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
C Q T C G P G NFDN +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
W D++Y+V DA + +IYF+ LII+GSFF++NL L V++ +FS+ +++ + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424
Query: 410 REQR 413
RE++
Sbjct: 425 REKQ 428
Score = 147 bits (370), Expect = 1e-34
Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)
Query: 674 GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
G E + + MP S++E+V T++ D+ + + L S +WR
Sbjct: 455 GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510
Query: 732 -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
C R V S F ++ + +NTL++ E++ QP LT + +N +LF E
Sbjct: 511 RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570
Query: 790 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
MLLK+ G Y + +N FD +V + E + + G+SVLR RL+R+ K+
Sbjct: 571 MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM LFG KF + + R
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
FD+ +++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+
Sbjct: 688 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 959 LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
+AI V+ ++ E + + +RKK S PE ++ L+ P +
Sbjct: 748 FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796
Query: 1018 IHTAATPMSLPKSTSTG 1034
+ + L T+ G
Sbjct: 797 GESKEEKIELKSITADG 813
Score = 119 bits (297), Expect = 4e-26
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 51/319 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAVF 1298
R C + +F +V+ ++FLN +TIA E H + +LT +N A+F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASE------HYNQPNWLTEVQDTANKALLALF 567
Query: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID-ILVSMVSDSGTKILGML--R 1355
AEM +K+ +LG QAY S +N D +V +++ ILV TKI+ L
Sbjct: 568 TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVE------TKIMSPLGIS 617
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
VLR +R LR ++ L +V +L++S++ I +++++ F IIF +LG+QLF GKF
Sbjct: 618 VLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF 677
Query: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
+ + R+ FDN Q+L+++F + + + W +MYDG+ A
Sbjct: 678 NFDEMQTRRS-------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGIMA 718
Query: 1476 VGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCR-----QHQEEEEAR 1530
G P M + +YFI + + +LN+F+ + V+N Q +EEEE
Sbjct: 719 YGGPSFPGM----LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774
Query: 1531 RREEKRLRRLEKKRRSKEK 1549
R++ R EKK+ EK
Sbjct: 775 RKKLARTASPEKKQELVEK 793
Score = 110 bits (276), Expect = 1e-23
Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
+ +P P + FF S ++R R C R V + F + + ILL+ ++L P +
Sbjct: 870 KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
S R IL D + F +E+++KM A G F K + + +N LD +V ++ +
Sbjct: 927 --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984
Query: 168 SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
+ ++ + R +RVLRPLRAINR ++ +V + + +GN++++ + F+F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 227 IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
+GVQL+ G L + + S + + Y T + E QPR
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089
Query: 287 TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
+W E++ F +FDN+ A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107
Query: 347 IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
+F V T EGW +++Y +D+H+ YN+ I+FI+ II+ +FFM+N+ + +
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 397 QFSETKQRE 405
F E ++E
Sbjct: 1168 TFQEQGEQE 1176
Score = 105 bits (261), Expect = 6e-22
Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ I Y PE+ +NA LE +F +F +E LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178
Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
+ YG P Y++N +N+ D +IVV+ ++ + G +G G V LR
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238
Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
FR++R L+LV +P+LQ L ++K M + +L++ I I++I+G+ LF K
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298
Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
+ D P NFD+ +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358
Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
+T E W VLY A W +YF+ L+ G++ + NL++ +L F E + K+
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query: 978 SE 979
+
Sbjct: 419 GD 420
Score = 104 bits (260), Expect = 8e-22
Identities = 70/267 (26%), Positives = 132/267 (49%), Gaps = 40/267 (14%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V+S YF + + IL+NT+ + ++++ Q A+ I N++FT LF +EM+LKL+ +
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIV-----------------GQQGGGLSV--LRTFRLM 839
P Y + +N FD +IVV S+ +I ++ +S+ R FR+M
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 840 RVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT 899
R++KL+ ++ L +K+ + +L+++ FI++++GM +FG K A D
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTE 1392
Query: 900 LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWA 940
+ NF + A++ +F+ T E W ++ M SS+A
Sbjct: 1393 INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA 1452
Query: 941 ALYFIALMTFGNYVLFNLLVAILVEGF 967
YFI+ +++ NL VA++++ F
Sbjct: 1453 VFYFISFYMLCAFLIINLFVAVIMDNF 1479
Score = 90.9 bits (224), Expect = 1e-17
Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)
Query: 595 TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
TS E +EK ++A ++ P L P S + +E +S G + KI+
Sbjct: 763 TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
L+ + D PY GE + + EMP + L + H +
Sbjct: 823 MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868
Query: 712 RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
+ P+A + + +RL C +IV+ F I+ IL++++S+ E Q
Sbjct: 869 EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 769 EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
N L ++ VFTS+F LE++LK+ YG F + +N +NI D ++V +S+
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984
Query: 824 GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
G Q ++V++ R++RVL+ +R L + + + V ++T+ N+ LL F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041
Query: 878 IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
+F+ +G+ LF CK + + +DG+ + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101
Query: 910 LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
L A++ +F + T E W ++LY + S + +++FI + + + N+
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161
Query: 960 VAILVEGFQAEGDANKSESEPD 981
V ++ FQ +G+ E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C V + F + + ++ LN +T+ E + + + + A F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
EM++KM +LG+ + Y +NR D F+V G+LE L + + S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 61.6 bits (148), Expect = 8e-09
Identities = 47/183 (25%), Positives = 83/183 (45%), Gaps = 31/183 (16%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V + +FE + ++ILLN + L M Q C A + F F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN------------------VSF 176
K++A F K Y D WN D IV+ +++ ++ N +S
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISI 1325
Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ R RV+R ++ ++R +R L+ + + L V LL +FFI+ ++G+Q++ +
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385
Query: 237 LRN 239
N
Sbjct: 1386 ALN 1388
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
L + ++ + S E+ + + AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 334 bits (857), Expect = 5e-91
Identities = 226/793 (28%), Positives = 411/793 (51%), Gaps = 74/793 (9%)
Query: 1117 QDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC 1176
++EEE E ++ + S + + +E+ A + +++ + TA G + +
Sbjct: 767 KEEEEEKERKKLARTASPEKKQELVEKPAVGE-SKEEKIELKSI--TADGESPPATKINM 823
Query: 1177 NGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAY-I 1235
+ + ++ P+ P G++ ++E + G R R L + SA+ I
Sbjct: 824 DDLQPNENEDKSPYPN-PETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query: 1236 FPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT 1295
F +RFRL CHRI+ +F +++L I L+ I++A E P + S L ++Y+FT
Sbjct: 883 FSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFT 941
Query: 1296 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLR 1355
++F E+ +K+ A G + ++ R+ +N+LD L+V +S+I + + + +++
Sbjct: 942 SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ------SSAINVVK 995
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
+LR+LR LRPLR I+RA+GLK VV+ + +++ IGNIV++ +F +GVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1416 FVCQGEDTRN--------ITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKD 1463
+ C + IT K + W K++FDN+ A+M+LF +++ +
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1464 GWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
GW +++Y +D+ D+ PI N+ + ++FI +++I+AFF++N+FVG V+ F Q
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QE 1171
Query: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Q E+E + E L+K +R + +A+ Y ++ + V ++ S Y + +
Sbjct: 1172 QGEQEYKNCE------LDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLM 1225
Query: 1584 TGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQ 1643
+I LN + +AM+HY Q + A+ I N +FT +F +E + KL+AF + +F D WN
Sbjct: 1226 FVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNT 1285
Query: 1644 LDLAIVLLSIMGITLEEIEVNASLPINPTI---------IRIMRVLRIARVLKLLKMAVG 1694
D IV+ SI+ I + E+ +P++ I R+ R+ R++KLL G
Sbjct: 1286 FDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEG 1345
Query: 1695 MRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNF 1754
+R LL T +++ + + LL ++LFFI+A +G+++FG + ++T + R+ F+ F
Sbjct: 1346 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT---TEINRNNNFQTF 1402
Query: 1755 GMAFLTLFRVSTGDNWNGIMKDTL--RDCDQESTCYNTV---------ISPIYFVSFVLT 1803
A L LFR +TG+ W IM + + C ES N+ + YF+SF +
Sbjct: 1403 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1462
Query: 1804 AQFVLVNVVIAVLM---------------KHLEESNK-EAKEEAELEAELE-LEMKTLSP 1846
F+++N+ +AV+M HL+E + A+ + E + ++ L++ TL
Sbjct: 1463 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLR 1522
Query: 1847 QPHSPLGSPFLWP 1859
+ PLG L P
Sbjct: 1523 RIQPPLGFGKLCP 1535
Score = 241 bits (616), Expect = 4e-63
Identities = 181/698 (25%), Positives = 327/698 (46%), Gaps = 109/698 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KIDPHSAERIFLTLSNYIFTAVFLAE 1301
R C I+ K F+ ++L+ IF NC+ +A+ P D +A L Y+F +F E
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVE 173
Query: 1302 MTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGM------L 1354
+KV+A G F AYLR+ WN+LD ++V++ + ++ + + G LG +
Sbjct: 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDV 233
Query: 1355 RVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGK 1414
+ LR R LRPLR++S L++V+ +++ ++ P+ +I ++ II+ I+G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 1415 FF-VCQGE----DTRNITNKSDCAEASYR-------------WVRHKY---NFDNLGQAL 1453
C + D + S CA + W K+ NFDN A+
Sbjct: 294 MHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAM 353
Query: 1454 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1513
+++F + +GW D++Y DAVG D W +YF++ ++I +FFVLN+ +GV+
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVL 404
Query: 1514 VE-------------NFHKCRQHQE--------------------EEEARRREEKRLRRL 1540
+F K R+ Q+ E E +E++ R +
Sbjct: 405 SGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNM 464
Query: 1541 EKKRRSKEK----------------------QMAEAQCKPYYSDYSRF-RLLVHHLCTSH 1577
E ++++++ Y+ ++RF R S+
Sbjct: 465 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSN 524
Query: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
+ ++ LN +T+A EHY QP L E N +F E + K+ + G + +F
Sbjct: 525 VFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYF 584
Query: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
+N+ D +V I+ L E ++ ++P I ++R +R+ R+ K+ + +
Sbjct: 585 VSLFNRFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSN 639
Query: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDLECDETHPCEGLGRHATFRNFGM 1756
L+ +++ ++ + +L LL L IF+ LG++LF G DE R +TF NF
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT-----RRSTFDNFPQ 694
Query: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
+ LT+F++ TG++WN +M D + S + ++ IYF+ + ++L+NV +A+
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIMAYGGPS--FPGMLVCIYFIILFICGNYILLNVFLAIA 752
Query: 1817 MKHL--EESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
+ +L ES A++E E E E + +T SP+ L
Sbjct: 753 VDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL 790
Score = 148 bits (374), Expect = 5e-35
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 70/364 (19%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C+ V FE I +L I NCV L ++ P + ++ L+ + F V
Sbjct: 114 RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSN-LERVEYLFLIIFTV 172
Query: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-------------- 175
E +K++A G+ F YL + WN LDF IV+ G+ L+ +
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
A+R RVLRPLR ++ VPS+++++ ++ + L ++ LL FV I+ I+G++L+ G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295
+ C+ E I P E+ C + G G
Sbjct: 293 KMHKTCYNQEG-----------------------IADVPAEDDPSPCAL------ETGHG 323
Query: 296 PPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEG 355
C Q T C G P G NFDN +A + +FQ IT+EG
Sbjct: 324 RQC-------------------QNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 356 WVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ESQLM 409
W D++Y+V DA + +IYF+ LII+GSFF++NL L V++ +FS+ +++ + Q +
Sbjct: 365 WTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424
Query: 410 REQR 413
RE++
Sbjct: 425 REKQ 428
Score = 147 bits (370), Expect = 1e-34
Identities = 111/377 (29%), Positives = 182/377 (48%), Gaps = 34/377 (9%)
Query: 674 GAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL-- 731
G E + + MP S++E+V T++ D+ + + L S +WR
Sbjct: 455 GMDEEKPRNMSMPTSETESVN--TENVAGGDIEGENCGAR--LAHRISKSKFSRYWRRWN 510
Query: 732 -ICDT-FRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALE 789
C R V S F ++ + +NTL++ E++ QP LT + +N +LF E
Sbjct: 511 RFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAE 570
Query: 790 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKL 844
MLLK+ G Y + +N FD +V + E + + G+SVLR RL+R+ K+
Sbjct: 571 MLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM LFG KF + + R
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD---EMQTRRS 687
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNL 958
FD+ +++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+
Sbjct: 688 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 959 LVAILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLL-PPLI 1017
+AI V+ ++ E + + +RKK S PE ++ L+ P +
Sbjct: 748 FLAIAVDNLADAESLTSAQKEE-------EEEKERKKLARTAS----PEKKQELVEKPAV 796
Query: 1018 IHTAATPMSLPKSTSTG 1034
+ + L T+ G
Sbjct: 797 GESKEEKIELKSITADG 813
Score = 119 bits (297), Expect = 4e-26
Identities = 96/319 (30%), Positives = 157/319 (49%), Gaps = 51/319 (15%)
Query: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAVF 1298
R C + +F +V+ ++FLN +TIA E H + +LT +N A+F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASE------HYNQPNWLTEVQDTANKALLALF 567
Query: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID-ILVSMVSDSGTKILGML--R 1355
AEM +K+ +LG QAY S +N D +V +++ ILV TKI+ L
Sbjct: 568 TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVE------TKIMSPLGIS 617
Query: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
VLR +R LR ++ L +V +L++S++ I +++++ F IIF +LG+QLF GKF
Sbjct: 618 VLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF 677
Query: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
+ + R+ FDN Q+L+++F + + + W +MYDG+ A
Sbjct: 678 NFDEMQTRRS-------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGIMA 718
Query: 1476 VGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCR-----QHQEEEEAR 1530
G P M + +YFI + + +LN+F+ + V+N Q +EEEE
Sbjct: 719 YGGPSFPGM----LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKE 774
Query: 1531 RREEKRLRRLEKKRRSKEK 1549
R++ R EKK+ EK
Sbjct: 775 RKKLARTASPEKKQELVEK 793
Score = 110 bits (276), Expect = 1e-23
Identities = 94/369 (25%), Positives = 166/369 (44%), Gaps = 74/369 (20%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
+ +P P + FF S ++R R C R V + F + + ILL+ ++L P +
Sbjct: 870 KAVPMPEAS--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT- 926
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEY 167
S R IL D + F +E+++KM A G F K + + +N LD +V ++ +
Sbjct: 927 --SFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF 984
Query: 168 SLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFG 226
+ ++ + R +RVLRPLRAINR ++ +V + + +GN++++ + F+F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 227 IVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVP 286
+GVQL+ G L + + S + + Y T + E QPR
Sbjct: 1045 CIGVQLFKGKL----YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR----------- 1089
Query: 287 TLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIA 346
+W E++ F +FDN+ A +A
Sbjct: 1090 ----------------------------SW----------ENSKF----DFDNVLAAMMA 1107
Query: 347 IFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIVGSFFMINLCLVVIAT 396
+F V T EGW +++Y +D+H+ YN+ I+FI+ II+ +FFM+N+ + +
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 397 QFSETKQRE 405
F E ++E
Sbjct: 1168 TFQEQGEQE 1176
Score = 105 bits (261), Expect = 6e-22
Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 62/302 (20%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA----LEISNIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ I Y PE+ +NA LE +F +F +E LK+
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKV 178
Query: 795 LVYG----PFGYIKNPYNIFDGVIVVISVWEIV-------------GQQGGGLSV--LRT 835
+ YG P Y++N +N+ D +IVV+ ++ + G +G G V LR
Sbjct: 179 IAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRA 238
Query: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-- 893
FR++R L+LV +P+LQ L ++K M + +L++ I I++I+G+ LF K
Sbjct: 239 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC 298
Query: 894 ---------ERDGDTLP--------------------------DRKNFDSLLWAIVTVFQ 918
+ D P NFD+ +A++TVFQ
Sbjct: 299 YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 358
Query: 919 ILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSE 977
+T E W VLY A W +YF+ L+ G++ + NL++ +L F E + K+
Sbjct: 359 CITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query: 978 SE 979
+
Sbjct: 419 GD 420
Score = 104 bits (260), Expect = 8e-22
Identities = 70/267 (26%), Positives = 132/267 (49%), Gaps = 40/267 (14%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
+V+S YF + + IL+NT+ + ++++ Q A+ I N++FT LF +EM+LKL+ +
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIV-----------------GQQGGGLSV--LRTFRLM 839
P Y + +N FD +IVV S+ +I ++ +S+ R FR+M
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 840 RVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT 899
R++KL+ ++ L +K+ + +L+++ FI++++GM +FG K A D
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIAL-NDTTE 1392
Query: 900 LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-------------------SSWA 940
+ NF + A++ +F+ T E W ++ M SS+A
Sbjct: 1393 INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA 1452
Query: 941 ALYFIALMTFGNYVLFNLLVAILVEGF 967
YFI+ +++ NL VA++++ F
Sbjct: 1453 VFYFISFYMLCAFLIINLFVAVIMDNF 1479
Score = 90.9 bits (224), Expect = 1e-17
Identities = 103/442 (23%), Positives = 192/442 (43%), Gaps = 76/442 (17%)
Query: 595 TSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQST---GACQSSCKIS 651
TS E +EK ++A ++ P L P S + +E +S G + KI+
Sbjct: 763 TSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKIN 822
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
L+ + D PY GE + + EMP + L + H +
Sbjct: 823 MDDLQPNENE---DKSPYPNPETTGEEDEEEPEMPVGP-----------RPRPLSELHLK 868
Query: 712 RQRSLGPDAEPSSVLAF---WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
+ P+A + + +RL C +IV+ F I+ IL++++S+ E Q
Sbjct: 869 EKAVPMPEASAFFIFSSNNRFRLQC---HRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 769 EELTN-ALEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIV 823
N L ++ VFTS+F LE++LK+ YG F + +N +NI D ++V +S+
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF- 984
Query: 824 GQQGGGLSVLRTFRLMRVLKLVRF------LPALQRQLVVLMKTMDNVATFCMLLMLFIF 877
G Q ++V++ R++RVL+ +R L + + + V ++T+ N+ LL F
Sbjct: 985 GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQ---F 1041
Query: 878 IFSILGMHLF----------------GCK--FASERDGDT----------LPDRKNFDSL 909
+F+ +G+ LF CK + + +DG+ + +FD++
Sbjct: 1042 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1101
Query: 910 LWAIVTVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLL 959
L A++ +F + T E W ++LY + S + +++FI + + + N+
Sbjct: 1102 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1161
Query: 960 VAILVEGFQAEGDANKSESEPD 981
V ++ FQ +G+ E D
Sbjct: 1162 VGFVIVTFQEQGEQEYKNCELD 1183
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/169 (27%), Positives = 82/169 (48%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R C V + F + + ++ LN +T+ E + + + + A F
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIAS----EHYNQPNWLTEVQDTANKALLALFTA 569
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD----LQNVSFSAVRTVRVLR 186
EM++KM +LG+ + Y +NR D F+V G+LE L + + S +R VR+LR
Sbjct: 570 EMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 626
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 627 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 61.6 bits (148), Expect = 8e-09
Identities = 47/183 (25%), Positives = 83/183 (45%), Gaps = 31/183 (16%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V + +FE + ++ILLN + L M Q C A + F F VEM++
Sbjct: 1216 VNSTYFEYLMFVLILLNTICLAMQHY-------GQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN------------------VSF 176
K++A F K Y D WN D IV+ +++ ++ N +S
Sbjct: 1269 KLIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISI 1325
Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ R RV+R ++ ++R +R L+ + + L V LL +FFI+ ++G+Q++ +
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385
Query: 237 LRN 239
N
Sbjct: 1386 ALN 1388
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 6/95 (6%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 391 LVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
L + ++ + S E+ + + AS
Sbjct: 749 LAIAVDNLADAESLTSAQKEEEEEKERKKLARTAS 783
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,516,055
Number of Sequences: 37866
Number of extensions: 5029902
Number of successful extensions: 41738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 276
Number of HSP's successfully gapped in prelim test: 565
Number of HSP's that attempted gapping in prelim test: 29926
Number of HSP's gapped (non-prelim): 7604
length of query: 2171
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2053
effective length of database: 13,779,330
effective search space: 28288964490
effective search space used: 28288964490
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.