Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 38490688
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38490688 immunoglobulin superfamily, member 10 [Homo
sapiens]
(2623 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 5271 0.0
gi|139948432 adlican [Homo sapiens] 940 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 335 3e-91
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 299 2e-80
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 299 2e-80
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 299 2e-80
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 245 4e-64
gi|110349719 titin isoform N2-A [Homo sapiens] 241 5e-63
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 207 1e-52
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 198 5e-50
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 186 3e-46
gi|224994173 roundabout 1 isoform d [Homo sapiens] 172 4e-42
gi|224994171 roundabout 1 isoform c [Homo sapiens] 172 4e-42
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 172 4e-42
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 172 4e-42
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 172 4e-42
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 172 4e-42
gi|109150416 peroxidasin [Homo sapiens] 171 9e-42
gi|19743806 roundabout 1 isoform b [Homo sapiens] 171 1e-41
gi|4506569 roundabout 1 isoform a [Homo sapiens] 171 1e-41
gi|75709184 contactin 3 [Homo sapiens] 170 1e-41
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 169 3e-41
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 162 3e-39
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 161 7e-39
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 161 7e-39
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 157 1e-37
gi|7657359 contactin 5 isoform long [Homo sapiens] 156 3e-37
gi|28373129 contactin 5 isoform short [Homo sapiens] 156 3e-37
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 155 6e-37
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 154 1e-36
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 5271 bits (13674), Expect = 0.0
Identities = 2623/2623 (100%), Positives = 2623/2623 (100%)
Query: 1 MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVE 60
MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVE
Sbjct: 1 MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVE 60
Query: 61 RINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKL 120
RINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKL
Sbjct: 61 RINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKL 120
Query: 121 QKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQ 180
QKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQ
Sbjct: 121 QKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQ 180
Query: 181 IFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDV 240
IFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDV
Sbjct: 181 IFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDV 240
Query: 241 IKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSS 300
IKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSS
Sbjct: 241 IKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSS 300
Query: 301 SAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFST 360
SAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFST
Sbjct: 301 SAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFST 360
Query: 361 FLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEA 420
FLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEA
Sbjct: 361 FLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEA 420
Query: 421 DLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNN 480
DLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNN
Sbjct: 421 DLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNN 480
Query: 481 TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM 540
TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM
Sbjct: 481 TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM 540
Query: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGI
Sbjct: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV 660
PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV
Sbjct: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV 660
Query: 661 SVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHN 720
SVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHN
Sbjct: 661 SVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHN 720
Query: 721 YRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPP 780
YRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPP
Sbjct: 721 YRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPP 780
Query: 781 PVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGT 840
PVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGT
Sbjct: 781 PVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGT 840
Query: 841 EFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGA 900
EFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGA
Sbjct: 841 EFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGA 900
Query: 901 TEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVRE 960
TEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVRE
Sbjct: 901 TEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVRE 960
Query: 961 VSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRG 1020
VSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRG
Sbjct: 961 VSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRG 1020
Query: 1021 RIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALS 1080
RIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALS
Sbjct: 1021 RIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALS 1080
Query: 1081 FPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTG 1140
FPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTG
Sbjct: 1081 FPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTG 1140
Query: 1141 AVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSR 1200
AVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSR
Sbjct: 1141 AVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSR 1200
Query: 1201 RKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVM 1260
RKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVM
Sbjct: 1201 RKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVM 1260
Query: 1261 QIPSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPA 1320
QIPSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPA
Sbjct: 1261 QIPSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPA 1320
Query: 1321 TTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLT 1380
TTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLT
Sbjct: 1321 TTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLT 1380
Query: 1381 TAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASET 1440
TAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASET
Sbjct: 1381 TAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASET 1440
Query: 1441 TLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTN 1500
TLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTN
Sbjct: 1441 TLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTN 1500
Query: 1501 TVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKS 1560
TVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKS
Sbjct: 1501 TVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKS 1560
Query: 1561 QNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSD 1620
QNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSD
Sbjct: 1561 QNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSD 1620
Query: 1621 FDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTI 1680
FDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTI
Sbjct: 1621 FDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTI 1680
Query: 1681 HWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSV 1740
HWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSV
Sbjct: 1681 HWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSV 1740
Query: 1741 VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVT 1800
VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVT
Sbjct: 1741 VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVT 1800
Query: 1801 VDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESL 1860
VDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESL
Sbjct: 1801 VDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESL 1860
Query: 1861 KLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIAT 1920
KLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIAT
Sbjct: 1861 KLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIAT 1920
Query: 1921 SSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSK 1980
SSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSK
Sbjct: 1921 SSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSK 1980
Query: 1981 AVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKI 2040
AVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKI
Sbjct: 1981 AVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKI 2040
Query: 2041 DHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFN 2100
DHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFN
Sbjct: 2041 DHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFN 2100
Query: 2101 NGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAV 2160
NGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAV
Sbjct: 2101 NGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAV 2160
Query: 2161 LDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSG 2220
LDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSG
Sbjct: 2161 LDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSG 2220
Query: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF
Sbjct: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
Query: 2281 LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR
Sbjct: 2281 LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
Query: 2341 NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK
Sbjct: 2341 NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
Query: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIP 2460
TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIP
Sbjct: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIP 2460
Query: 2461 KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVP 2520
KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVP
Sbjct: 2461 KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVP 2520
Query: 2521 VMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHG 2580
VMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHG
Sbjct: 2521 VMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHG 2580
Query: 2581 SEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
SEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI
Sbjct: 2581 SEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 940 bits (2430), Expect = 0.0
Identities = 577/1627 (35%), Positives = 858/1627 (52%), Gaps = 112/1627 (6%)
Query: 1069 RERLTTATAALSFPSAAPITFPKADIARV--PSEESTTLVQNPLLLLENK-PSVEKTTPT 1125
+ R T +T + + P P+ + PS E+ L + L E S++ T T
Sbjct: 1240 KHRYTPSTVSSRASGSKPSPSPENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTT 1299
Query: 1126 IKYFRT--EISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITS-SLS 1182
K + + ++ + P +TY PTS E V ++ ++ K D ++T S++
Sbjct: 1300 RKIYSSYPKVQETLP----VTYKPTSDGKEIKDDV------ATNVDKHKSDILVTGESIT 1349
Query: 1183 GAITKPPMTIIAITRFSRRKIPWQQNFVNNHNPK-----GRLRNQHKVSLQKSTAVMLPK 1237
AI + + F P NP GRL+ V+ P
Sbjct: 1350 NAIPTSRSLVSTMGEFKEESSPVGFPGTPTWNPSRTAQPGRLQTGIPVTTSGENLTDPPL 1409
Query: 1238 ---------TSPALPRDKVS-PFH------FTTLSTSVMQIPSN-----TLTTAHHTTT- 1275
TS L VS PFH TTLS+ +++ S+ TL H TT
Sbjct: 1410 LKELEDVDFTSEFLSSLTVSTPFHQEEAGSSTTLSSIKVEVASSQAETTTLDQDHLETTV 1469
Query: 1276 -----KTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASVI 1330
+T PT + P SS +I+ + T P P+ I
Sbjct: 1470 AILLSETRPQNHTPTAARMKEPA-----------SSSPSTILMSLGQTTTTKPALPSPRI 1518
Query: 1331 TYETQTERSRA-----QTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETS 1385
+ ++ + + E P T P++ S TP++ + +
Sbjct: 1519 SQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELS---TPSSDQDAFNLSTKLE 1575
Query: 1386 VKPSVSAFTHSP--PENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLS 1443
++ V P P++ + H T I A + + AS ++
Sbjct: 1576 LEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVRLPEMSTQSASRYFVT 1635
Query: 1444 SKSHQSTTTRKAIIRHST---------IPPFLSSSATLMPVPISPPFTQRAVTDNVATPI 1494
S+S + T + I + + P LSS+ +P+ +S P TD
Sbjct: 1636 SQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSKPSIPSKFTDRRTDQF 1695
Query: 1495 SG---LMTNTVVKLHESSRHNAKPQQLVAEVATSPKV--HPNAK---FTIGTTHFIYSNL 1546
+G + N + E+ KP SP++ + N + FT T F +
Sbjct: 1696 NGYSKVFGNN--NIPEARNPVGKPP--------SPRIPHYSNGRLPFFTNKTLSFPQLGV 1745
Query: 1547 LHSTPMPALTTVKSQNSKLTPSPWAE---NQFWHKPYSEIAEKGKKPEVSMLATTGLSEA 1603
+P + K+ P + + +H + A P + TTG S +
Sbjct: 1746 TRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAP----PLLHTPQTTG-SPS 1800
Query: 1604 TTLVSDWDGQKNTKKSDFDKKPVQEA-----TTSKLL---PFDSLSRYIFEKPRIVGGKA 1655
T L + F VQ + ++SK P S + EKP+I+
Sbjct: 1801 TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP 1860
Query: 1656 ASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEI 1715
+ ++ A +D PCEA G P P + WT+V +G ++ + R +VL NGTL I++V++
Sbjct: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV 1920
Query: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775
QDRGQY+C+ASNL G D + V LSV P+IL +++TV+ G T+ ++C A+G P+P
Sbjct: 1921 QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP 1980
Query: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKI 1835
++WI ++ V S + + + TL + S DRG YKCVASN G DSL +++
Sbjct: 1981 QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
Query: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLF 1895
V A PPVI +++ + I G S+ + CTAK P PSV WVL DGT+++P QF + LF
Sbjct: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
Query: 1896 LFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNF 1955
+F NGTLYIRNLA D G YEC+A + GS RR V L ++ + RI S +RT+V +
Sbjct: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY 2160
Query: 1956 GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYL 2015
G L L+CSA+G+P P+I+WRLPSK ++D S I V+ NG+L + SVT+KD+G YL
Sbjct: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL 2220
Query: 2016 CVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLP 2075
CVARNK+GDD +++ V + +KPAKI+HK+ +V +G D +VDC A+G P PEISWSLP
Sbjct: 2221 CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP 2280
Query: 2076 DGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLT 2135
DG+++N+ MQ+DDSG RT+RY +FNNGTLYFN+VG+ EEGDYTC+A+N +GKDEM+V +
Sbjct: 2281 DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK 2340
Query: 2136 VITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHAN 2195
V+TA IR ++ GD + CE G+P PK+ WL P+N +I S ++Y + +
Sbjct: 2341 VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD 2400
Query: 2196 GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
G+L I K + DSG Y C+ RN +G+D K + V +PP ING T ++ A S
Sbjct: 2401 GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS 2460
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
+K DC+AEG P+P V+W P+ + L APYYG+RITVH NG+L+IR++R SDS +C+A
Sbjct: 2461 RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA 2520
Query: 2316 RNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPN 2375
RNEGGE+ L++QL VLE + +P F +P +EKI A G + +LNCS G P P ++W+LPN
Sbjct: 2521 RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN 2580
Query: 2376 GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL 2435
GT +G Q ++ ++G IS + DAG YRC ARN G+ E+LV L++G KP
Sbjct: 2581 GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN 2640
Query: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495
V I+GE+L L C G + WT+P+G ++ PQ G+ L DNGTL ++E
Sbjct: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE 2700
Query: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGV 2555
A+ +DRG Y+C+ + G ++ ++PV+++AYPPRIT+ P I TR G +L+C+A+G+
Sbjct: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI 2760
Query: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
PK +ITWE+PD S L + R +G+ LH QG+L IQ+ D+G YKC AKN LGSD
Sbjct: 2761 PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS 2820
Query: 2616 AATYIQV 2622
TYI V
Sbjct: 2821 KTTYIHV 2827
Score = 861 bits (2225), Expect = 0.0
Identities = 747/2739 (27%), Positives = 1183/2739 (43%), Gaps = 295/2739 (10%)
Query: 28 ACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLM 87
ACP CACY+P+EVHCTFR L S+P I +VERINLG+NS+ L ET F+GLTKLELLM
Sbjct: 26 ACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQALSETSFAGLTKLELLM 85
Query: 88 LHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPE 147
+H N I +IPD DL +LQV K SYNK+R + T GL +L RLH+DHN IEFI+P+
Sbjct: 86 IHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKIEFIHPQ 145
Query: 148 VFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSY 207
F GL LRL+HLEGN L +LHP TF + ++L F++S I+ LYL++N + +LP M+
Sbjct: 146 AFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLPASMLRN 205
Query: 208 MPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGK 267
MP L++LYL GNPWTCDC ++W +W + ++KCKKD++ Q C +C +P+
Sbjct: 206 MPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILKCKKDKAYEGGQLCAMCFSPKKLYKH 265
Query: 268 PLAMVSAAAFQCAKPTIDSSLK-SKSLTI-----LEDSSSAFISPQGFMAPFGSLTLNMT 321
+ + C KP+I+S L+ ++S +I E+ + + + F P S++LNMT
Sbjct: 266 EIHKLK--DMTCLKPSIESPLRQNRSRSIEEEQEQEEDGGSQLILEKFQLPQWSISLNMT 323
Query: 322 DQSGNEANMVCSIQKPSRTSPIAFTE-ENDYIVLNTSFSTFLVCNIDYGHIQPVWQILAL 380
D+ GN N+VC I+KP I + + I +N + + C + + + +W+++A
Sbjct: 324 DEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINATVALDFECPMTRENYEKLWKLIAY 383
Query: 381 YSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNR 440
YS+ P+ L R +LS+ P++ Y+Y+Q A + +T + A + A+P W+MQ I +QLNR
Sbjct: 384 YSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTGVRAQILAEPEWVMQPSIDIQLNR 443
Query: 441 TATTFSTLQIQYSSDAQITLPRAEMRPVK-HKWTMISRDNNTKLEHTVLVGGTVGLNCPG 499
+T + + Y + T+ + R + W MI + + TVL GG L+C
Sbjct: 444 RQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNV 503
Query: 500 QGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDA 559
+ +P + W+L DGS ++AP D + I SG L ++ + D+G+Y CI+ D+
Sbjct: 504 KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEM 563
Query: 560 DILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSS 619
D + YR+ V P + +++ + GE++ LPC++ IP+A +SW++P ++ +
Sbjct: 564 DRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLA 623
Query: 620 RDKKV--LNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK--------GQRP 669
V L NGTL I +V D GYYRCVA N G D ++V K G+RP
Sbjct: 624 NTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
Query: 670 ------------LEHDGETEGSGL-DESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTS 716
+E +G GSG+ DE N L P ++ +A G +
Sbjct: 684 GAKALSRVREDIVEDEG---GSGMGDEENTSRRLLHPKDQEVFLKTKDDAINGDKKAKKG 740
Query: 717 KR------HNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPD 770
+R H+ +E + RR E+RR + ++I+P+ WA +L K + +P
Sbjct: 741 RRKLKLWKHSEKE---PETNVAEGRRVFESRRRINMANKQINPERWADILAKVRGKNLPK 797
Query: 771 KRE-----NTTVSP--------------PPVVTQLPNIPGEEDDSSGMLALHEEFMVPAT 811
E TT P PP + + + E+ S+ + L EE V T
Sbjct: 798 GTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEESSADVPLLGEEEHVLGT 857
Query: 812 --------------------KALNLPARTVTAD-SRTISDSPMTNINYGTEFSPVVNSQI 850
+ + P V D S + T + +P + S+
Sbjct: 858 ISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITSTEGDLKGTAAPTLISEP 917
Query: 851 LPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMG 910
P PT L T + + S+ G++ + +S+ + L A +S+ M
Sbjct: 918 YEP-SPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEYEPPLDAVSLAESEPM- 975
Query: 911 RGREHFQSRPPITVRTM-----IKDVNVKMLSSTTNKLLLESVNTTNSHQTSVREVSEPR 965
++F P + ++ +K+ L+ T + +S + +++ E P
Sbjct: 976 ---QYFD--PDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFEDSTIGEPGVPG 1030
Query: 966 HNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRGRIISP 1025
+H T I H S + T+ I + Q GG P
Sbjct: 1031 QSHLQGLTDNI----------HLVKSS---LSTQDTLLIKKGMKEMSQTLQGGNMLEGDP 1077
Query: 1026 YRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALSFPSAA 1085
H S S + G KS T +T+ ++ +S + + TT L +
Sbjct: 1078 -------THSRS---SESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTT 1127
Query: 1086 PITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY 1145
T P+ +A S+T+ +P +P+ + K FR Q PT T+
Sbjct: 1128 ATTTPRQKVA-----PSSTMSTHP---SRRRPNGRRRLRPNK-FRHRHKQTPPT----TF 1174
Query: 1146 APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPW 1205
AP+ E P + +++ + V T+ + + P +++
Sbjct: 1175 APS----ETFSTQPTQAPDIKISSQVESSLVPTAWVDNTVNTP------------KQLEM 1218
Query: 1206 QQNFVNNHNPKGRLRNQHKVSLQK---STAVMLPKTSPALPRDKVSPFHFTTLSTSVMQI 1262
++N KG R +H K + + + + S + P H ++ S
Sbjct: 1219 EKN--AEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPSPENKHRNIVTPS---- 1272
Query: 1263 PSNTLTTAHHTTTKTHNP----GSLPTKKEL--PFPPLNPMLPSIISKDSSTKSI---IS 1313
S T+ + KT P + T +++ +P + LP S K I ++
Sbjct: 1273 -SETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPTSDGKEIKDDVA 1331
Query: 1314 TQTAIPATTPTFPASVITYETQTERSRAQTI---QREQEPQKKNRTDPNISPDQS----- 1365
T + IT T RS T+ + E P T P +P ++
Sbjct: 1332 TNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGT-PTWNPSRTAQPGR 1390
Query: 1366 --SGFTTPTA----MTPPVLTTAE--TSVKPSVSAFTHSPPENTTGISSTISFHSRTLNL 1417
+G T+ PP+L E +S+ T S P + S+ + S + +
Sbjct: 1391 LQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSSTTLSSIKVEV 1450
Query: 1418 TDVIEELAQASTQTLKSTIA---SETTLSSKSHQSTTTR---KAIIRHSTIPPFLSSSAT 1471
E L++T+A SET ++H T R A STI L + T
Sbjct: 1451 ASSQAETTTLDQDHLETTVAILLSET--RPQNHTPTAARMKEPASSSPSTILMSLGQTTT 1508
Query: 1472 LMPVPISPPFTQ--RAVTDNV-ATPISGLMTNTVVKLHESSRHNAKPQQLVAEVATSPKV 1528
P SP +Q R +NV + T +E ++H + P +L ++P
Sbjct: 1509 TKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNEL-----STPSS 1563
Query: 1529 HPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKG- 1587
+A F + T + + S +P + Q+ ++ A +Q P I
Sbjct: 1564 DQDA-FNLSTKLELEKQVFGSRSLPRGPDSQRQDGRV----HASHQLTRVPAKPILPTAT 1618
Query: 1588 -KKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYI-F 1645
+ PE+S + + + W + P + T+ L ++ +
Sbjct: 1619 VRLPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHM 1678
Query: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAV--GNPLPTIHWTRVPSGLDLSKR---KQNSRV 1700
KP I + FT +D F V N +P R P G S R N R+
Sbjct: 1679 SKPSI----PSKFT-DRRTDQFNGYSKVFGNNNIPE---ARNPVGKPPSPRIPHYSNGRL 1730
Query: 1701 QVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRT---KEITV 1757
N TLS ++ + R Q S + P + ER+ +
Sbjct: 1731 PFFTNKTLSFPQLGVTRRPQIPTSPA------------------PVMRERKVIPGSYNRI 1772
Query: 1758 HSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVV-TVDGTLVLHNLSIYDRG 1816
HS ST L G P+P + + QT S S+ +V + ++ S+ G
Sbjct: 1773 HSHSTFHLDF---GPPAPPL--LHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSG 1827
Query: 1817 FYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYW 1876
+ +S K + P IL + Q + T PC A G P+P V W
Sbjct: 1828 SFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTW 1887
Query: 1877 V-LSDGTEVKPLQFTNSKLFLF---SNGTLYIRNLASSDRGTYECIATSSTGSERRVVML 1932
+S G + P N+++ F NGTL IR + DRG Y C A++ G +R VV+L
Sbjct: 1888 TKVSTGALMTP----NTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLL 1943
Query: 1933 TMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW 1992
++ V P+I A+ + V GD + + C A G P PQI W P + V V
Sbjct: 1944 SV--TVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGR 2001
Query: 1993 IHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH 2052
I ++ N +L I + D GVY CVA N G D + + + + P I ++ +
Sbjct: 2002 ITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPP 2061
Query: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
G + C A +P+P + W L DGT I S +F NGTLY +
Sbjct: 2062 GLSIHIHCTAKAAPLPSVRWVLGDGTQIR------PSQFLHGNLFVFPNGTLYIRNLAPK 2115
Query: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKR--IKAGDTAVLDCEVTGDPK 2170
+ G Y C A N +G V L V AA R + + +R ++ G T LDC +GDP
Sbjct: 2116 DSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPW 2175
Query: 2171 PKIFWLLPSNDMIS--FSID-RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYK 2227
P+I W LPS MI FS D R ANG+L + V D+G+Y+CVARN GDD + K
Sbjct: 2176 PRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLK 2235
Query: 2228 LDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPD----NIFLTA 2283
+DVV KP I N + DC A G P+PE+ W +PD N F+ +
Sbjct: 2236 VDVVMKPAKIEHKEENDHKV----FYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
Query: 2284 PYYG---SRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
G R V NGTL V + + D+ C A N+ G+ + V+++V + T R
Sbjct: 2292 DDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV--VTAPATIR 2349
Query: 2341 NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
N + G + C G P P++ W+ P + YQ I +G+ +I K
Sbjct: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQ--IYQDGTLLIQK 2407
Query: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPG---TVKGIS--GESLSLHCV 2455
R D+G Y C RN G K V + + +P + P TV+ I+ G + C
Sbjct: 2408 AQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCK 2467
Query: 2456 SDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHT 2515
++GIP P + W P G V+ P + +H NG+L I+ D +C A+N G
Sbjct: 2468 AEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEA 2527
Query: 2516 LITVPVMIVAYPPRITNRPPRS--IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTA 2573
+ + + ++ + P S I G L+C A G P P + W +P+ + L +
Sbjct: 2528 RLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSG 2587
Query: 2574 SKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
+ + + G L I + D+G Y+C A+N G
Sbjct: 2588 QQLQRFYHK---ADGMLHISGLSSVDAGAYRCVARNAAG 2623
Score = 393 bits (1009), Expect = e-108
Identities = 263/969 (27%), Positives = 437/969 (45%), Gaps = 41/969 (4%)
Query: 1674 GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDH 1733
G P P + T +G S QN + ++S +Q G + S+S F
Sbjct: 1783 GPPAPPLLHTPQTTGSP-STNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGP 1841
Query: 1734 LHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQG 1793
+ P+IL + + ++V + + C A G+P P VTW + + +
Sbjct: 1842 PASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTR 1901
Query: 1794 SRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIV 1853
++ V +GTLV+ + + DRG Y C ASN G D ++V + V P IL Q +
Sbjct: 1902 IQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVT 1961
Query: 1854 GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
G+++ + C AKGTP P + W+ D + + ++ L N TL I+ + SDRG
Sbjct: 1962 VYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021
Query: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQI 1973
Y+C+A+++ G++ + L + P I + + G + ++C+A P P +
Sbjct: 2022 VYKCVASNAAGADSLAIRLHVA--ALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
Query: 1974 MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDD--LILMHV 2031
W L + + + V+PNG+L+I ++ KDSG Y CVA N +G + ++V
Sbjct: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
Query: 2032 SLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGH 2091
A+I R V +G ++DC ASG P P I W LP MI+ D
Sbjct: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDS--- 2196
Query: 2092 RTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNK 2151
R +F NGTL V + GDY C A+N +G D + + + V+ +I + +
Sbjct: 2197 ---RIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDH 2253
Query: 2152 RIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSID---------RYTFHANGSLTINK 2202
++ G +DC TG P P+I W LP +++ + RY NG+L N+
Sbjct: 2254 KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNE 2313
Query: 2203 VKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCR 2262
V + + G+Y C A N G D ++ VV+ P I N+T + C
Sbjct: 2314 VGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR----NKTYLAVQVPYGDVVTVACE 2369
Query: 2263 AEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGES 2322
A+G P P+V W+ P N + P + ++++GTL I+ + SDS ++ C+ RN GE
Sbjct: 2370 AKGEPMPKVTWLSPTNKVI--PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGED 2427
Query: 2323 VLVVQLEVLEMLRRPTFR---NPFNE-KIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR 2378
V + V ++ P NP + +A G ++C +G P P ++W P G
Sbjct: 2428 RKTVWIHV--NVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVV 2485
Query: 2379 FSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG---YIEKLVILEIGQKPVIL 2435
+ + NGS I + D+ + C ARN+ G I +L +LE +KP+
Sbjct: 2486 LPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH 2545
Query: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495
+ ++G ++SL+C + G P P++ W +P+G + Q ++ +G L I
Sbjct: 2546 DPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISG 2605
Query: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTR-TGAAFQLHCVALG 2554
++ D G Y C A+N+ GHT V + + P N+ ++V+ G +L C G
Sbjct: 2606 LSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE--ANKQYHNLVSIINGETLKLPCTPPG 2663
Query: 2555 VPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
+ +W +P+ L +T G L GTL ++ D G Y C + G
Sbjct: 2664 AGQGRFSWTLPNGMHLEGP---QTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPS 2720
Query: 2615 YAATYIQVI 2623
+ + VI
Sbjct: 2721 VTSIPVIVI 2729
Score = 80.5 bits (197), Expect = 2e-14
Identities = 50/175 (28%), Positives = 84/175 (48%), Gaps = 6/175 (3%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
++C +G PTP V W +G + APY RI + +G L+++ D+ C++
Sbjct: 2464 IDCKAEGIPTPRVLWAFPEGVVLPAPYYGN--RITVHGNGSLDIRSLRKSDSVQLVCMAR 2521
Query: 555 NYDDADILTYRITVVEPLVEAYQENGIHH--TVFIGETLDLPCHSTGIPDASISWVIPGN 612
N L ++TV+EP+ + + I T G T+ L C + G P S+ WV+P
Sbjct: 2522 NEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNG 2581
Query: 613 NVLYQSSRDKKVLN--NGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK 665
L + ++ + +G L I ++ D G YRCVA N +G + + V +K
Sbjct: 2582 TDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLK 2636
Score = 75.1 bits (183), Expect = 8e-13
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 9/164 (5%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T + G T+ LNC G PTP + W+L +G+ +++ + R G L + S D
Sbjct: 2553 TAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQ--RFYHKADGMLHISGLSSVD 2610
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI--GETLDLPCHSTGIPDA 603
G Y C++ N A T R+ ++ ++ H+ V I GETL LPC G
Sbjct: 2611 AGAYRCVARN---AAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQG 2667
Query: 604 SISWVIPGNNVLY--QSSRDKKVLNNGTLRILQVTPKDQGYYRC 645
SW +P L Q+ +L+NGTL + + + D+G Y C
Sbjct: 2668 RFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVC 2711
Score = 68.9 bits (167), Expect = 6e-11
Identities = 47/180 (26%), Positives = 78/180 (43%), Gaps = 5/180 (2%)
Query: 2445 ISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQIN--GKYILHDNGTLVIKEATAYDRG 2502
+ G L C P+I W +P G ++ P + K+ + +G L IK D G
Sbjct: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
Query: 2503 NYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITW 2562
Y C AQ + V++ + + + +I G + L C AL +P+ ++W
Sbjct: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
Query: 2563 EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+P+ +++ + + GTL I Q SDSG Y+C A N G+D+ I V
Sbjct: 612 ILPNRRIINDLANT---SHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
Score = 65.1 bits (157), Expect = 9e-10
Identities = 49/180 (27%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
+++ G T+ L C G W L +G + P GR+ + +G L ++ A FD
Sbjct: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTL--GRVSLLDNGTLTVREASVFD 2705
Query: 546 TGVYHC-ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI-----GETLDLPCHSTG 599
G Y C + + Y + +T + +V AY + G T+ L C + G
Sbjct: 2706 RGTYVCRMETEYGPS------VTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMG 2759
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNN-----GTLRILQVTPKDQGYYRCVAANPSGVD 654
IP A I+W +P + L + + N G+L I T +D G+Y+C+A N G D
Sbjct: 2760 IPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSD 2819
Score = 43.1 bits (100), Expect = 0.004
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSE-DGRILIDKSGKLELQMADSFDTGV 548
G TV LNC G P + W L D S ++A + G + G L +Q A D G
Sbjct: 2748 GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGF 2807
Query: 549 YHCISSNYDDADILTYRITV 568
Y C++ N +D T I V
Sbjct: 2808 YKCMAKNILGSDSKTTYIHV 2827
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 335 bits (860), Expect = 3e-91
Identities = 261/877 (29%), Positives = 393/877 (44%), Gaps = 64/877 (7%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
P I GG S I N L C A G P P I W + + L ++R +L NG
Sbjct: 3713 PNIKGGPQ-SLVILLNKSTVLECIAEGVPTPRITWRKDGAVL----AGNHARYSILENGF 3767
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L IQ + D G+YLC A+N GTD + L V PP I T +TV L C
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV-HVPPSIAPGPTN-MTVIVNVQTTLAC 3825
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG 1827
A G P P++ W + + +Q S + + + G+LV+ + S+ D Y+C +N G
Sbjct: 3826 EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSS--GSLVIISPSVDDTATYECTVTNGAG 3883
Query: 1828 QDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPL 1887
D V + V PP I ++ +V ++ + CTA G P PS++W +G + P
Sbjct: 3884 DDKRTVDLTV-QVPPSIADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWT-KNGIRLLP- 3939
Query: 1888 QFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAAS 1947
+ S+G + I + G Y C+A ++ GS R V L + E P +
Sbjct: 3940 --RGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHE----PPVIQPQ 3993
Query: 1948 QKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007
V + +LL C ATG P P I W+ V + G V P+G L I
Sbjct: 3994 PSELHVILNNPILLPCEATGTPSPFITWQKEGINV----NTSGRNHAVLPSGGLQISRAV 4049
Query: 2008 EKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDH-KQYFRKQVLHGKDFQVDCKASGSP 2066
+D+G Y+CVA+N G L + +++++ P H K+Y + K + C+A G P
Sbjct: 4050 REDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYV---IAVDKPITLSCEADGLP 4106
Query: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
P+I+W DG I ++ R + ++G+L V + G YTC A N G
Sbjct: 4107 PPDITWH-KDGRAIVESI----------RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155
Query: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
LTV PRIR S + + + A+L C G P P I W N +++
Sbjct: 4156 SSSTSTKLTV-HVPPRIR-STEGHYTVNENSQAILPCVADGIPTPAINWK-KDNVLLANL 4212
Query: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTV 2246
+ +YT G L + V L DSG Y CVA N +G+DT L V P L + ++
Sbjct: 4213 LGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSL-TVHVLPTFTELPGDVSL 4271
Query: 2247 IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLS 2306
K +R S C+A G P P++ W +NI P + + H L I V
Sbjct: 4272 NKGEQLRLS-----CKATGIPLPKLTWTFNNNII---PAHFDSVNGHSE--LVIERVSKE 4321
Query: 2307 DSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPP 2366
DS ++C A N G V + + + P F+ + + LG + LNC V G+P
Sbjct: 4322 DSGTYVCTAENSVG---FVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 2367 PEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVIL 2426
P I W + + S++ NGS I T EDAG Y C A N+ G +E+ + L
Sbjct: 4379 PTIQW----NRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSL 4434
Query: 2427 EIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILH 2486
+ Q P I+T P +G + L+C + G P+P I W+ + ++N +
Sbjct: 4435 TL-QSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVN----VL 4489
Query: 2487 DNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI 2523
N +L I +A D + C A+N +G L+ VPV++
Sbjct: 4490 SNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 319 bits (818), Expect = 2e-86
Identities = 283/982 (28%), Positives = 423/982 (43%), Gaps = 74/982 (7%)
Query: 1646 EKPRI-VGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP 1704
E P++ V K SFT S+ + C A G P P I WT + S R ++
Sbjct: 610 EPPKVTVMPKNQSFT--GGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHR-----YRMTS 662
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
+GTL I+ +D G Y C ASN GTD + TL + P ++ + E+ V G
Sbjct: 663 DGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ--SELLVALGDITV 720
Query: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
++C+ G P P V W + E + + + G L + D G Y CVA N
Sbjct: 721 MECKTSGIPPPQVKWFKGDL----ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAIN 776
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G+ + + + V +PPV +++ V + G ++ LPC +G P+P++ W D +
Sbjct: 777 EAGRATGKITLDV-GSPPVFIQEPADVSMEI-GSNVTLPCYVQGYPEPTIKWRRLDNMPI 834
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
F+ S + G L+I NL +SD+GTY C A + G + +T+ V +P I
Sbjct: 835 FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLV-APLI- 892
Query: 1945 AASQKRTEVNFGDKLLLNCS-ATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI 2003
S V G +L L C+ G P P+ W + + A++ Q +I V +GSL I
Sbjct: 893 GISPSVANVIEGQQLTLPCTLLAGNPIPERRW-IKNSAMLLQ----NPYITVRSDGSLHI 947
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKAS 2063
V +D G Y CVA N G + V + + P I H Q + G + CKAS
Sbjct: 948 ERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT-IQHGQQI-LSTIEGIPVTLPCKAS 1005
Query: 2064 GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQN 2123
G+P P + WS G +I+ + + +++ +G+LY G E G+Y C A N
Sbjct: 1006 GNPKPSVIWS-KKGELISTS---------SAKFSAGADGSLYVVSPGGEESGEYVCTATN 1055
Query: 2124 TLGKDEMKVHLTVITAAPRI-------RQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWL 2176
T G + KV LTV PR+ Q + AG+ L CEV P P I W
Sbjct: 1056 TAGYAKRKVQLTVY-VRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWA 1114
Query: 2177 LPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPL 2236
+ + FS R+TF +GS+ I + + DSG Y+CVA N +G+ T+ KL+V P +
Sbjct: 1115 KETQLISPFS-PRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 2237 INGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG 2296
G + + + C A+GTP P + W + L G + +G
Sbjct: 1174 QRGPKHLKVQV------GQRVDIPCNAQGTPLPVITWSKGGSTMLVD---GEHHVSNPDG 1224
Query: 2297 TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLR----RPTFRNPFNEKIVAQLG 2352
TL I SD+ + CVA N G + L V E P + F E++ Q
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-- 1282
Query: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
C G P P I W L NG R G + ++ +I+ T D G+Y C
Sbjct: 1283 -RIEFPCPAKGTPKPTIKW-LHNG-RELTGREPGISILEDGTLLVIASVTPYDNGEYICV 1339
Query: 2413 ARNKVGYIEKLVILEIGQKPVILTYAPGT-VKGISGESLSLHCVSDGIPKPNIKWTMPSG 2471
A N+ G E+ L++ PVI T V + + +L C +G P P I W +
Sbjct: 1340 AVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNV 1399
Query: 2472 YVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRIT 2531
V + I +++ L + AT D G Y CKA N G + + ++ P I
Sbjct: 1400 QVTESSTIQ---TVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 2532 NRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSL-LSTASKERTHGSEQLHLQGTL 2590
P + L C G P P+I W L L + E + LHL
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHL---- 1512
Query: 2591 VIQNPQTSDSGIYKCTAKNPLG 2612
+N + +D G Y+CT N G
Sbjct: 1513 --KNARRNDKGRYQCTVSNAAG 1532
Score = 311 bits (798), Expect = 4e-84
Identities = 273/977 (27%), Positives = 403/977 (41%), Gaps = 70/977 (7%)
Query: 1644 IFEKPRIVGGK--AASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQ 1701
++ P I G K A ++ + C A G P P I+W + L LS S ++
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLS-----SHIR 3390
Query: 1702 VLPNG-TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSG 1760
+L G + I R ++ D Y C ASN G D+ H L V + P T+EITV G
Sbjct: 3391 LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKG 3450
Query: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKC 1820
S+ + C +G P+P++ W+ Q + + V T L L D G Y C
Sbjct: 3451 SSTSMACITDGTPAPSMAWLRDGQPL----GLDAHLTVSTHGMVLQLLKAETEDSGKYTC 3506
Query: 1821 VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+ASN G+ S ++V+ P + + + I L+L C A G P P + W + D
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW-MKD 3565
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
G +PL T+ L L I D G Y C+A+S G + + ++ +
Sbjct: 3566 G---RPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVH---VP 3619
Query: 1941 PRIEAASQKR-TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG 1999
P I + R V ++ L C + P P I W + + + + + G
Sbjct: 3620 PNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERL-----QATPRVRILSGG 3674
Query: 2000 S-LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQV 2058
L I + D+ Y CVA N G +++ + P Q +L K +
Sbjct: 3675 RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSL--VILLNKSTVL 3732
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
+C A G P P I+W + N RY++ NG L+ V + G Y
Sbjct: 3733 ECIAEGVPTPRITWRKDGAVLAGN----------HARYSILENGFLHIQSAHVTDTGRYL 3782
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A N G D ++ L V P TN + L CE TG PKP I W
Sbjct: 3783 CMATNAAGTDRRRIDLQV--HVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 2179 SNDM-ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
+ + + + + Y ++GSL I + D+ Y C N +GDD + L V PP I
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDL-TVQVPPSI 3899
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
T+ V K H+ C A G P P + W + I L G RI +G
Sbjct: 3900 ADEPTDFLVTK-----HAPAVITCTASGVPFPSIHW-TKNGIRLLPRGDGYRIL--SSGA 3951
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL 2357
+EI +L+ + + CVARN G + V L V E P P ++ L L
Sbjct: 3952 IEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHE----PPVIQPQPSELHVILNNPILL 4007
Query: 2358 NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKV 2417
C G P P I W G + +++ L +G IS+ REDAG Y C A+N
Sbjct: 4008 PCEATGTPSPFITW-QKEGINVNTSGRNHAVL--PSGGLQISRAVREDAGTYMCVAQNPA 4064
Query: 2418 GYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRP 2477
G + L + PVI + V + + ++L C +DG+P P+I W +V+
Sbjct: 4065 GTALGKIKLNVQVPPVISPHLKEYVIAVD-KPITLSCEADGLPPPDITWHKDGRAIVE-- 4121
Query: 2478 QINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRS 2537
I + + +G+L I D G+Y C A N G + T + V PPRI +
Sbjct: 4122 SIRQRVL--SSGSLQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHY 4178
Query: 2538 IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQT 2597
V A L CVA G+P P I W+ D+ LL+ G G L+++N
Sbjct: 4179 TVNENSQAI-LPCVADGIPTPAINWK-KDNVLLANLL-----GKYTAEPYGELILENVVL 4231
Query: 2598 SDSGIYKCTAKNPLGSD 2614
DSG Y C A N G D
Sbjct: 4232 EDSGFYTCVANNAAGED 4248
Score = 310 bits (794), Expect = 1e-83
Identities = 259/974 (26%), Positives = 417/974 (42%), Gaps = 63/974 (6%)
Query: 1659 TIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDR 1718
T+ A L C + + W R + L+ + +R++ L N +L ++ V+ D
Sbjct: 530 TVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLA---EPARIRTLANLSLELKSVKFNDA 586
Query: 1719 GQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVT 1778
G+Y C S+ G+ V L+V P + + + T GS V + C A G P P +
Sbjct: 587 GEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFT--GGSEVSIMCSATGYPKPKIA 644
Query: 1779 WILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVI 1838
W + + +V GS + +T DGTL + N + D G Y C+ASN G D ++ I
Sbjct: 645 WTVNDMFIV-----GSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYI 699
Query: 1839 AAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFS 1898
AP +++ Q ++ G+ + C G P P V W D E++P F L
Sbjct: 700 EAPKLMVVQSELLV--ALGDITVMECKTSGIPPPQVKWFKGD-LELRPSTFLIIDPLL-- 754
Query: 1899 NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDK 1958
G L I+ D G Y C+A + G R +T++ V SP + + G
Sbjct: 755 -GLLKIQETQDLDAGDYTCVAINEAG--RATGKITLD--VGSPPVFIQEPADVSMEIGSN 809
Query: 1959 LLLNCSATGEPKPQIMW-RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCV 2017
+ L C G P+P I W RL + + + V S I G+LFI ++ D G Y+C
Sbjct: 810 VTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSS-ISQLRTGALFILNLWASDKGTYICE 868
Query: 2018 ARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK-ASGSPVPEISWSLPD 2076
A N+ G V++ A + V+ G+ + C +G+P+PE W
Sbjct: 869 AENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNS 928
Query: 2077 GTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV 2136
++ N T+ ++G+L+ +V + + G+YTC A N G + K V
Sbjct: 929 AMLLQNPY-----------ITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNN-KTTSVV 976
Query: 2137 ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
+ P I+ + I+ G L C+ +G+PKP + W ++IS S +++ A+G
Sbjct: 977 VHVLPTIQHGQQILSTIE-GIPVTLPCKASGNPKPSVIW-SKKGELISTSSAKFSAGADG 1034
Query: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI---NGLYTNRTVIKATAVR 2253
SL + +SGEYVC A N +G + +L V +P + GL ++ V + + +
Sbjct: 1035 SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPV-EISVLA 1093
Query: 2254 HSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFIC 2313
+ C + P P + W L +P + R T +G+++I R SDS ++C
Sbjct: 1094 GEEVTLPCEVKSLPPPIITWAKETQ--LISP-FSPRHTFLPSGSMKITETRTSDSGMYLC 1150
Query: 2314 VARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
VA N G V+L V + R P + K+ Q+G+ + C+ G P P I W
Sbjct: 1151 VATNIAGNVTQAVKLNV--HVPPKIQRGPKHLKV--QVGQRVDIPCNAQGTPLPVITWSK 1206
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
T +G ++ +G+ I + T DAG Y C A N G E + L + + P
Sbjct: 1207 GGSTMLVDGE---HHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPT 1263
Query: 2434 ILTYAP----GTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG 2489
+ P + ++ + + C + G PKP IKW + R G IL D
Sbjct: 1264 VEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP--GISILEDGT 1321
Query: 2490 TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLH 2549
LVI T YD G YIC A N G T + + P ++ L
Sbjct: 1322 LLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLF 1381
Query: 2550 CVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
C G P P I W D+ ++ +S +T + ++ L + D+G Y C A N
Sbjct: 1382 CEVEGTPSPIIMW-YKDNVQVTESSTIQTVNNGKI-----LKLFRATPEDAGRYSCKAIN 1435
Query: 2610 PLGSDYAATYIQVI 2623
G+ I V+
Sbjct: 1436 IAGTSQKYFNIDVL 1449
Score = 306 bits (784), Expect = 2e-82
Identities = 263/975 (26%), Positives = 402/975 (41%), Gaps = 86/975 (8%)
Query: 1659 TIPANSDAFLPCEAVGNPLPTIHWTR--VPSGLDLSKRKQNSRVQVLPNG-TLSIQRVEI 1715
T+ S + C G P P++ W R P GLD + + V +G L + + E
Sbjct: 3446 TVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLD-------AHLTVSTHGMVLQLLKAET 3498
Query: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775
+D G+Y C ASN G H L V+ P +EI+V + +EL C A G P+P
Sbjct: 3499 EDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAP 3558
Query: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLH--NLSIYDRGFYKCVASNPGGQDSLLV 1833
+TW+ + + V T+ G VL + D G Y C+AS+P G D
Sbjct: 3559 KMTWMKDGRPLPQTDQ------VQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEY 3612
Query: 1834 KIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSK 1893
++V P + + I + L C + P P + W+ + + LQ T
Sbjct: 3613 LVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNG----ERLQATPRV 3668
Query: 1894 LFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEV 1953
L L I N D Y C+A++ G R +LT+ P I+ Q +
Sbjct: 3669 RILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVN---VPPNIKGGPQSLV-I 3724
Query: 1954 NFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV 2013
+L C A G P P+I WR + R + NG L I S D+G
Sbjct: 3725 LLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYS----ILENGFLHIQSAHVTDTGR 3780
Query: 2014 YLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWS 2073
YLC+A N G D + + + + P+ V+ + C+A+G P P I+W
Sbjct: 3781 YLCMATNAAGTDRRRIDLQVHVPPSIAPGPT--NMTVIVNVQTTLACEATGIPKPSINWR 3838
Query: 2074 LPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVH 2133
+G ++N + Y L ++G+L V + Y C N G D+ V
Sbjct: 3839 -KNGHLLNVDQNQNS-------YRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVD 3890
Query: 2134 LTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFW------LLPSNDMISFSI 2187
LTV P T+ + AV+ C +G P P I W LLP D
Sbjct: 3891 LTV--QVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGD------ 3942
Query: 2188 DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVI 2247
Y ++G++ I +L +G Y CVARN +G + L V +PP+I + VI
Sbjct: 3943 -GYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHV-HEPPVIQPQPSELHVI 4000
Query: 2248 KATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSD 2307
+ C A GTPSP + W + I + G V +G L+I D
Sbjct: 4001 LNNPIL-----LPCEATGTPSPFITW-QKEGINVNTS--GRNHAVLPSGGLQISRAVRED 4052
Query: 2308 SADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPP 2367
+ ++CVA+N G ++ ++L V + P +P ++ V + K L+C DG PPP
Sbjct: 4053 AGTYMCVAQNPAGTALGKIKLNV----QVPPVISPHLKEYVIAVDKPITLSCEADGLPPP 4108
Query: 2368 EIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILE 2427
+I W +S + + S+GS I+ DAG Y C A N G L
Sbjct: 4109 DITWHKDGRAIV----ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLT 4164
Query: 2428 IGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHD 2487
+ P I + + +++ L CV+DGIP P I W + + + + GKY
Sbjct: 4165 VHVPPRIRSTEGHYTVNENSQAI-LPCVADGIPTPAINWKKDNVLLAN---LLGKYTAEP 4220
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQ 2547
G L+++ D G Y C A N+ G TV + + P P + G +
Sbjct: 4221 YGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPT--FTELPGDVSLNKGEQLR 4278
Query: 2548 LHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTA 2607
L C A G+P P++TW ++ + + H LVI+ DSG Y CTA
Sbjct: 4279 LSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE--------LVIERVSKEDSGTYVCTA 4330
Query: 2608 KNPLGSDYAATYIQV 2622
+N +G A ++ V
Sbjct: 4331 ENSVGFVKAIGFVYV 4345
Score = 303 bits (777), Expect = 1e-81
Identities = 265/969 (27%), Positives = 423/969 (43%), Gaps = 74/969 (7%)
Query: 1648 PRIVG-GKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG 1706
P I G + T+ N L C++ P P I W R L + R V++L G
Sbjct: 3620 PNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR-----VRILSGG 3674
Query: 1707 T-LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVEL 1765
L I ++ D Y C ASN+ G L+V + PP I + + + STV L
Sbjct: 3675 RYLQINNADLGDTANYTCVASNIAGKTTREFILTV-NVPPNIKGGPQSLVILLNKSTV-L 3732
Query: 1766 KCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNP 1825
+C AEG P+P +TW + ++ S + +G L + + + D G Y C+A+N
Sbjct: 3733 ECIAEGVPTPRITWRKDGAVLAGNHARYS----ILENGFLHIQSAHVTDTGRYLCMATNA 3788
Query: 1826 GGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVK 1885
G D + +QV P + ++ L C A G P+PS+ W +G +
Sbjct: 3789 AGTDRRRIDLQVHVPPSIAPGPTNMTVIVN--VQTTLACEATGIPKPSINW-RKNGHLLN 3845
Query: 1886 PLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEA 1945
Q NS L S+G+L I + + D TYEC T+ G ++R V LT++ P A
Sbjct: 3846 VDQNQNSYRLL-SSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV----PPSIA 3900
Query: 1946 ASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGS 2005
V ++ C+A+G P P I W ++ + G + +G++ I +
Sbjct: 3901 DEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPR----GDGYRILSSGAIEILA 3956
Query: 2006 VTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGS 2065
+G Y CVARN G HV+L + + Q V+ + C+A+G+
Sbjct: 3957 TQLNHAGRYTCVARNAAGS--AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGT 4014
Query: 2066 PVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTL 2125
P P I+W +G +N + R + + +G L ++ + G Y C AQN
Sbjct: 4015 PSPFITWQ-KEGINVNTS---------GRNHAVLPSGGLQISRAVREDAGTYMCVAQNPA 4064
Query: 2126 GKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISF 2185
G K+ L V P + + I L CE G P P I W ++
Sbjct: 4065 GTALGKIKLNV--QVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES 4122
Query: 2186 SIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRT 2245
R ++GSL I V+ D+G Y C+A N +G + KL V PP I + T
Sbjct: 4123 IRQRVL--SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKL-TVHVPPRIRSTEGHYT 4179
Query: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRL 2305
V + +S+ C A+G P+P + W DN+ L A G + T G L + NV L
Sbjct: 4180 VNE-----NSQAILPCVADGIPTPAINW-KKDNVLL-ANLLG-KYTAEPYGELILENVVL 4231
Query: 2306 SDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNP 2365
DS + CVA N GE V L V + PTF + + G+ L+C G P
Sbjct: 4232 EDSGFYTCVANNAAGEDTHTVSLTVHVL---PTFTELPGD-VSLNKGEQLRLSCKATGIP 4287
Query: 2366 PPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI 2425
P++ W N N ++ + + +I + ++ED+G Y C A N VG+++ +
Sbjct: 4288 LPKLTWTFNN-----NIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGF 4342
Query: 2426 LEIGQKPVIL-TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYI 2484
+ + + PV Y ++ + G ++ L+C G P P I+W + +I+ +
Sbjct: 4343 VYVKEPPVFKGDYPSNWIEPLGGNAI-LNCEVKGDPTPTIQWNRKGVDI----EISHRIR 4397
Query: 2485 LHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGA 2544
NG+L I D G+Y C A N G ++ + + + PP IT P +++ G
Sbjct: 4398 QLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQS-PPIITLEPVETVI-NAGG 4455
Query: 2545 AFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYK 2604
L+C A G P+P ITW HS+ + +R + + +L I + Q D+ ++
Sbjct: 4456 KIILNCQATGEPQPTITWSRQGHSI---SWDDRVN----VLSNNSLYIADAQKEDTSEFE 4508
Query: 2605 CTAKNPLGS 2613
C A+N +GS
Sbjct: 4509 CVARNLMGS 4517
Score = 301 bits (772), Expect = 4e-81
Identities = 275/1000 (27%), Positives = 422/1000 (42%), Gaps = 80/1000 (8%)
Query: 1644 IFEKPRIVGG-------KAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQ 1696
++ +PR+ G K ++ A + LPCE P P I W + +
Sbjct: 1068 VYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLIS----PF 1123
Query: 1697 NSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEIT 1756
+ R LP+G++ I D G YLC A+N+ G V L+V PP+I +R K +
Sbjct: 1124 SPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNV-HVPPKI-QRGPKHLK 1181
Query: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
V G V++ C A+G P P +TW T++ + V DGTL + + D G
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHH----VSNPDGTLSIDQATPSDAG 1237
Query: 1817 FYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGES-----LKLPCTAKGTPQ 1871
Y CVA+N G D + + V P V E T+ E ++ PC AKGTP+
Sbjct: 1238 IYTCVATNIAGTDETEITLHVQEPPTV--EDLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295
Query: 1872 PSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLY-IRNLASSDRGTYECIATSSTGSERRVV 1930
P++ W L +G E L + + +GTL I ++ D G Y C+A + G+ R
Sbjct: 1296 PTIKW-LHNGRE---LTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKY 1351
Query: 1931 MLTMEERVTSPRIEAASQKRTEVNFGDKLLLN--CSATGEPKPQIMWRLPSKAVVDQQHR 1988
L +V P + ++ T V+ L N C G P P IMW + V +
Sbjct: 1352 NL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES--- 1404
Query: 1989 VGSWIHVYPNGSLF-IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFR 2047
S I NG + + T +D+G Y C A N G ++ + + P I
Sbjct: 1405 --STIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNE 1462
Query: 2048 KQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNG-TLYF 2106
V+ +D ++C+ G+P P+I W DG + D + L + G L+
Sbjct: 1463 VSVVLNRDVALECQVKGTPFPDIHW-FKDGKPL---FLGDPN------VELLDRGQVLHL 1512
Query: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNK-RIKAGDTAVLDCEV 2165
++G Y C N GK + LT+ P I+ N T + L+CE
Sbjct: 1513 KNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIP-PSIKGGNVTTDISVLINSLIKLECET 1571
Query: 2166 TGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKM 2225
G P P I W ++S S Y L I + ++ DS Y C N +G K
Sbjct: 1572 RGLPMPAITWYKDGQPIMSSSQALY-IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKS 1630
Query: 2226 YKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPY 2285
+ +DV PP+I G + K + HS +C+A G PSP + W+ D + + A
Sbjct: 1631 FHVDVYV-PPMIEGNLAT-PLNKQVVIAHSLT-LECKAAGNPSPILTWLK-DGVPVKA-- 1684
Query: 2286 YGSRITVHKNGT-LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFN 2344
I + G LEI + + D +ICVA + GE + +++VL P
Sbjct: 1685 -NDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVP---PAIEGGDE 1740
Query: 2345 EK-IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG-SFIISKTT 2402
+ + L+C V G+PPP I+W L +G + + I NG +I++
Sbjct: 1741 TSYFIVMVNNLLELDCHVTGSPPPTIMW-LKDGQLID---ERDGFKILLNGRKLVIAQAQ 1796
Query: 2403 REDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKP 2462
+ G YRC A N G +K + + P I + + + ++L C+++GIP P
Sbjct: 1797 VSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNP 1856
Query: 2463 NIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM 2522
+I W + V+ Q N K I L I + D G Y C A N+ G T + +
Sbjct: 1857 SITW-LKDDQPVNTAQGNLK-IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLH 1914
Query: 2523 IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSE 2582
+ P + QL C A G P P ITW D+ LLS ++
Sbjct: 1915 VHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITW-YKDNRLLSGSTSMTFLNRG 1973
Query: 2583 QLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Q+ + I++ Q SD+GIYKC A N G+ +QV
Sbjct: 1974 QI-----IDIESAQISDAGIYKCVAINSAGATELFYSLQV 2008
Score = 296 bits (758), Expect = 2e-79
Identities = 263/993 (26%), Positives = 409/993 (41%), Gaps = 93/993 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
P + + A ++ S+ LPC G P PTI W R+ + S+ S + L G
Sbjct: 792 PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA 851
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L I + D+G Y+C A N FG T++V ++ V G + L C
Sbjct: 852 LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPC 911
Query: 1768 R-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPG 1826
G P P WI + ++ + V DG+L + + + D G Y CVASN
Sbjct: 912 TLLAGNPIPERRWIKNSAMLLQ-----NPYITVRSDGSLHIERVQLQDGGEYTCVASNVA 966
Query: 1827 GQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKP 1886
G ++ + V P + + +Q++ G + LPC A G P+PSV W + +
Sbjct: 967 GTNNKTTSVVVHVLPTI--QHGQQILSTIEGIPVTLPCKASGNPKPSVIW----SKKGEL 1020
Query: 1887 LQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT--MEERVTSPRIE 1944
+ +++K ++G+LY+ + + G Y C AT++ G +R V LT + RV +
Sbjct: 1021 ISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRG 1080
Query: 1945 AASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVY-PNGSL 2001
+ K E++ G+++ L C P P I W ++ + R H + P+GS+
Sbjct: 1081 LSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR-----HTFLPSGSM 1135
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
I DSG+YLCVA N G+ + +++ + P ++ + QV G+ + C
Sbjct: 1136 KITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQV--GQRVDIPCN 1193
Query: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYA 2121
A G+P+P I+WS TM+ D H + +GTL ++ ++ G YTC A
Sbjct: 1194 AQGTPLPVITWSKGGSTML-----VDGEHHVSN-----PDGTLSIDQATPSDAGIYTCVA 1243
Query: 2122 QNTLGKDEMKVHLTVITAAPRIRQ----SNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL 2177
N G DE ++ L V P + N T + A C G PKP I WL
Sbjct: 1244 TNIAGTDETEITLHV-QEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLH 1302
Query: 2178 PSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
++ L I V D+GEY+CVA N +G + Y L V PP+I
Sbjct: 1303 NGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLK-VHVPPVI 1361
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
V + + + + C EGTPSP +MW DN+ +T + TV+
Sbjct: 1362 K---DKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMW-YKDNVQVTES--STIQTVNNGKI 1415
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL 2357
L++ D+ + C A N G S ++VL + F ++ L + AL
Sbjct: 1416 LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL--VPPTIIGTNFPNEVSVVLNRDVAL 1473
Query: 2358 NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKV 2417
C V G P P+I W F P L+ + R D G+Y+C N
Sbjct: 1474 ECQVKGTPFPDIHWFKDGKPLFLGDPN--VELLDRGQVLHLKNARRNDKGRYQCTVSNAA 1531
Query: 2418 GYIEKLVILEIGQKPVILTYAPGTVKG---------ISGESLSLHCVSDGIPKPNIKWTM 2468
G K + L I Y P ++KG + + L C + G+P P I W
Sbjct: 1532 GKQAKDIKLTI--------YIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITW-- 1581
Query: 2469 PSGYVVDRPQINGKYILH-DNGT-LVIKEATAYDRGNYICKAQNSVG------HTLITVP 2520
Y +P ++ L+ D G L I A D Y C N G H + VP
Sbjct: 1582 ---YKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVP 1638
Query: 2521 VMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHG 2580
MI N+ + ++ + L C A G P P +TW L + +
Sbjct: 1639 PMIEGNLATPLNK--QVVIAH---SLTLECKAAGNPSPILTW-------LKDGVPVKAND 1686
Query: 2581 SEQLHLQG-TLVIQNPQTSDSGIYKCTAKNPLG 2612
+ ++ G L I + Q D G Y C A + G
Sbjct: 1687 NIRIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719
Score = 282 bits (722), Expect = 3e-75
Identities = 255/992 (25%), Positives = 414/992 (41%), Gaps = 88/992 (8%)
Query: 1644 IFEKPRIVGGKAAS-FTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV 1702
I+ P I GG + ++ NS L CE G P+P I W + D +S+
Sbjct: 1542 IYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYK-----DGQPIMSSSQALY 1596
Query: 1703 LPNGT-LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERR-----TKEIT 1756
+ G L I R ++ D Y C +N+ GT + V Y P ++E K++
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDV--YVPPMIEGNLATPLNKQVV 1654
Query: 1757 VHSGSTVELKCRAEGRPSPTVTW------ILANQTVVSESSQGSRQAVVTVDGTLVLHNL 1810
+ T+E C+A G PSP +TW + AN + E+ G + +++
Sbjct: 1655 IAHSLTLE--CKAAGNPSPILTWLKDGVPVKANDNIRIEAG-GKKLEIMSAQEI------ 1705
Query: 1811 SIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTP 1870
DRG Y CVA++ G+ + ++ V+ P + + L+L C G+P
Sbjct: 1706 ---DRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 1871 QPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVV 1930
P++ W L DG + + L + L I S+ G Y C+A ++ G ++
Sbjct: 1763 PPTIMW-LKDGQLIDE---RDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEF 1818
Query: 1931 MLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVG 1990
+T+ P I+++ V + L C A G P P I W + V Q
Sbjct: 1819 EVTVH---VPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGN-- 1873
Query: 1991 SWIHVYPNGSLF-IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQ 2049
+ + +G + I +D+G Y CVA N G+ + + + P+ D + +
Sbjct: 1874 --LKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNET 1931
Query: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLY-FNK 2108
VL Q++CKA+G+PVP I+W D +++ + T N G +
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITW-YKDNRLLSGSTS----------MTFLNRGQIIDIES 1980
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGD 2168
+++ G Y C A N+ G E+ L V AP I SN + + L+CE G
Sbjct: 1981 AQISDAGIYKCVAINSAGATELFYSLQV-HVAPSISGSNNM-VAVVVNNPVRLECEARGI 2038
Query: 2169 PKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKL 2228
P P + WL + + SFS L + ++ D+G Y CVA N +G+ K +
Sbjct: 2039 PAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGE--KQRDI 2096
Query: 2229 DV-VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYG 2287
D+ V PP I G N +V+ + AV C+++ P P + W+ + L P G
Sbjct: 2097 DLRVYVPPNIMGEEQNVSVLISQAV-----ELLCQSDAIPPPTLTWLKDGHPLLKKP--G 2149
Query: 2288 SRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNE-- 2345
I+ +++ L+I + ++ D+ + C A N G++ + + P +E
Sbjct: 2150 LSISENRS-VLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWV----PPNIGGSDELT 2204
Query: 2346 KIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTRED 2405
++ G +L C G PPP +IW G+ +++ IS + D
Sbjct: 2205 QLTVIEGNLISLLCESSGIPPPNLIW-KKKGSPVLTDSMGRVRILSGGRQLQISIAEKSD 2263
Query: 2406 AGKYRCAARNKVGYIEKLVILEIGQKPVILTYA--PGTVKGISGESLSLHCVSDGIPKPN 2463
A Y C A N G +K L++ +P I P + G+S+SL C GIP P
Sbjct: 2264 AALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPT 2323
Query: 2464 IKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI 2523
+ W M G+ + + + G IL + L +K D G Y+C A N G T + +
Sbjct: 2324 VTW-MKDGHPLIKAK--GVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSV 2380
Query: 2524 VAYPPRITN-RPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSE 2582
A P I N R P +I + L C A G+P P ITW + + S G
Sbjct: 2381 HAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGR 2440
Query: 2583 QLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
L L T + D+G Y C +N G +
Sbjct: 2441 MLRLMQTTM------EDAGQYTCVVRNAAGEE 2466
Score = 282 bits (721), Expect = 4e-75
Identities = 258/987 (26%), Positives = 416/987 (42%), Gaps = 84/987 (8%)
Query: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNS---RV 1700
++ P I G + ++ L C+A G P PTI W L KR +NS V
Sbjct: 3147 VYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAW------LKNHKRIENSDSLEV 3200
Query: 1701 QVLPNGT-LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHS 1759
++L G+ L I R + D G Y C ASN+ G + LS+ P +++V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1760 GSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG-TLVLHNLSIYDRGFY 1818
G VEL C A G P+P + W+ + + S ++ R V+ +G TL ++ D G Y
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIR---VSANGSTLNIYGALTSDTGKY 3317
Query: 1819 KCVASNPGGQDSLLVKIQVIAAPPVI-LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWV 1877
CVA+NP G++ + + V P + + + ++ S+ + C A GTP P + W
Sbjct: 3318 TCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW- 3376
Query: 1878 LSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEER 1937
L +G PL ++ L + + I SD Y C+A++ G + + L +
Sbjct: 3377 LKNGL---PLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNL----Q 3429
Query: 1938 VTSPRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHV 1995
V +P S E+ G + C G P P + W + + H + V
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAH-----LTV 3484
Query: 1996 YPNGS-LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLR-LKPAKID-HKQYFRKQVLH 2052
+G L + +DSG Y C+A N+ G+ + H L+ L+P I+ +++ V+
Sbjct: 3485 STHGMVLQLLKAETEDSGKYTCIASNEAGE--VSKHFILKVLEPPHINGSEEHEEISVIV 3542
Query: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
++ C ASG P P+++W + DG + Q TL L + V
Sbjct: 3543 NNPLELTCIASGIPAPKMTW-MKDGRPLPQTDQVQ---------TLGGGEVLRISTAQVE 3592
Query: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNK-RIKAGDTAVLDCEVTGDPKP 2171
+ G YTC A + G D+ K +L + P I +++ + L+C+ P P
Sbjct: 3593 DTGRYTCLASSPAGDDD-KEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPP 3651
Query: 2172 KIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
I WL N + R + G L IN L D+ Y CVA N +G T+ + L
Sbjct: 3652 VITWL--RNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL-T 3708
Query: 2231 VSKPPLINGLYTNRTVI--KATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGS 2288
V+ PP I G + ++ K+T + +C AEG P+P + W D L + +
Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVL-------ECIAEGVPTPRITW-RKDGAVLAGNH--A 3758
Query: 2289 RITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIV 2348
R ++ +NG L I++ ++D+ ++C+A N G + L+V P P +
Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV----HVPPSIAPGPTNMT 3814
Query: 2349 AQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGK 2408
+ T L C G P P I W NG + Y + S+GS +I + +D
Sbjct: 3815 VIVNVQTTLACEATGIPKPSINW-RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTAT 3873
Query: 2409 YRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTM 2468
Y C N G ++ V L + Q P + P + C + G+P P+I WT
Sbjct: 3874 YECTVTNGAGDDKRTVDLTV-QVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTK 3932
Query: 2469 PSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVG--HTLITVPVMIVAY 2526
++ R Y + +G + I G Y C A+N+ G H +T+ V +
Sbjct: 3933 NGIRLLPR---GDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHV----H 3985
Query: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL 2586
P + P + L C A G P P ITW+ ++ + R H +
Sbjct: 3986 EPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG---INVNTSGRNHA---VLP 4039
Query: 2587 QGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
G L I D+G Y C A+NP G+
Sbjct: 4040 SGGLQISRAVREDAGTYMCVAQNPAGT 4066
Score = 279 bits (713), Expect = 3e-74
Identities = 250/1000 (25%), Positives = 410/1000 (41%), Gaps = 88/1000 (8%)
Query: 1648 PRIVGGKAA--SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
P I+G + + ++ + L CEA G PLP+I W + + LS + V++L
Sbjct: 2384 PSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLS-----NSVRILSG 2438
Query: 1706 GT-LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
G L + + ++D GQY C N G + LSV+ P + E +++ V +V
Sbjct: 2439 GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVT 2498
Query: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
L C G P P +TW Q + + + +++ L + N+ + G Y C+AS+
Sbjct: 2499 LTCEVTGNPVPEITWHKDGQPLQEDEA----HHIISGGRFLQITNVQVPHTGRYTCLASS 2554
Query: 1825 PGGQDSLLVKIQVIAAPPVI---LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
P G S + V +P + + + + L C A P ++ W DG
Sbjct: 2555 PAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW-FKDG 2613
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
T PL+ + L TL I N + G Y C+AT+ G ++ E +V P
Sbjct: 2614 T---PLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGE----MIKHYEVKVYIP 2666
Query: 1942 RI--------EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWI 1993
I S K ++ + L L C A P + W + + H +
Sbjct: 2667 PIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH-----V 2721
Query: 1994 HVYPNG-SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA---------KID-H 2042
++ NG +L I D+G Y CVA N G+D + V++++ P+ +D
Sbjct: 2722 NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTG 2781
Query: 2043 KQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNG 2102
+ K V+ + C+ + +P P ++W DG + ++ + L
Sbjct: 2782 RNGEAKDVIINNPISLYCETNAAPPPTLTW-YKDGHPLTSS---------DKVLILPGGR 2831
Query: 2103 TLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNK---TNKRIKAGDTA 2159
L + V + G YTC A N G+D ++ + V+ P I+ +N + +A
Sbjct: 2832 VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL-VPPIIKGANSDLPEEVTVLVNKSA 2890
Query: 2160 VLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNP 2218
+++C +G P P+ W ++ D + F +NG L I ++ D G YVCVA N
Sbjct: 2891 LIECLSSGSPAPRNSWQKDGQPLL--EDDHHKFLSNGRILQILNTQITDIGRYVCVAENT 2948
Query: 2219 SGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDN 2278
+G K + L+V P +I N TV+ + C G P P++ W+ +
Sbjct: 2949 AGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFI-----SLTCEVSGFPPPDLSWLKNEQ 3003
Query: 2279 IFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPT 2338
+ + V TL+I ++SD ++ C+A N+ GES L V P+
Sbjct: 3004 ---PIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYV---PPS 3057
Query: 2339 FRNPFNEK---IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGS 2395
++ +E + + G S +L C + PPP I W NG + ++ ++A
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITW-YKNGRMITE--STHVEILADGQM 3114
Query: 2396 FIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCV 2455
I K D G+Y C A N G +K L + P I + ++L C
Sbjct: 3115 LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD 3174
Query: 2456 SDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHT 2515
+ GIP P I W + + + + IL L I + D GNY C A N G
Sbjct: 3175 ATGIPPPTIAWLKNHKRIENSDSLEVR-ILSGGSKLQIARSQHSDSGNYTCIASNMEGKA 3233
Query: 2516 LITVPVMIVAYPPRITNRP-PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTAS 2574
+ + PP + P + G +L C A G+P P I W + D +++
Sbjct: 3234 Q-KYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQW-LKDGKPIASGE 3291
Query: 2575 KERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
ER S TL I TSD+G Y C A NP G +
Sbjct: 3292 TERIRVSAN---GSTLNIYGALTSDTGKYTCVATNPAGEE 3328
Score = 270 bits (690), Expect = 1e-71
Identities = 268/1020 (26%), Positives = 442/1020 (43%), Gaps = 94/1020 (9%)
Query: 1622 DKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGK-----AASFTIPANSDAF------LPC 1670
D P EA K+ +D Y+F++ V A T+P + + +PC
Sbjct: 393 DFVPPNEAFFLKVTGYDK-DDYLFQRVSSVSFSSIVPDAPKVTMPEKTPGYYLQPGQIPC 451
Query: 1671 EAVGNPLP-TIHWTR--VPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727
+V + LP T+ + R V G+D K+++ V L I +V + D G Y C A +
Sbjct: 452 -SVDSLLPFTLSFVRNGVTLGVD-QYLKESASVN------LDIAKVTLSDEGFYECIAVS 503
Query: 1728 LFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV- 1786
GT T VS PP +++ +TV G L C +TW ++ V
Sbjct: 504 SAGTGRAQ-TFFDVSEPPPVIQ-VPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVR 561
Query: 1787 VSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILE 1846
++E ++ A ++++ L ++ D G Y C+ S+ GG + V + V P V +
Sbjct: 562 LAEPARIRTLANLSLE----LKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVM 617
Query: 1847 QRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRN 1906
+ Q G G + + C+A G P+P + W ++D V ++ + S+GTL+I+N
Sbjct: 618 PKNQSFTG--GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYR-----MTSDGTLFIKN 670
Query: 1907 LASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSAT 1966
A D G Y C+A++S G++++ L + +P++ Q V GD ++ C +
Sbjct: 671 AAPKDAGIYGCLASNSAGTDKQNSTL---RYIEAPKLMVV-QSELLVALGDITVMECKTS 726
Query: 1967 GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP-NGSLFIGSVTEKDSGVYLCVARNKMGDD 2025
G P PQ+ W D + R +++ + P G L I + D+G Y CVA N+ G
Sbjct: 727 GIPPPQVKW-----FKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 781
Query: 2026 LILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQ 2085
+ + + P I ++ G + + C G P P I W D I +
Sbjct: 782 TGKITLDVGSPPVFIQEPADVSMEI--GSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPF 839
Query: 2086 ADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQ 2145
+ S + R G L+ + +++G Y C A+N GK + + +TV +
Sbjct: 840 SVSSISQLR------TGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIG 893
Query: 2146 SNKTNKRIKAGDTAVLDCE-VTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVK 2204
+ + + G L C + G+P P+ W+ N + T ++GSL I +V+
Sbjct: 894 ISPSVANVIEGQQLTLPCTLLAGNPIPERRWI--KNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 2205 LLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTV--IKATAVRHSKKHFDCR 2262
L D GEY CVA N +G + K + V P + +G T+ I T C+
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVT--------LPCK 1003
Query: 2263 AEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGES 2322
A G P P V+W + T+ ++ + +G+L + + +S +++C A N G +
Sbjct: 1004 ASGNPKPSVIWSKKGELISTS---SAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYA 1060
Query: 2323 VLVVQLEVLEMLRRPTFRNPFNE----KIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR 2378
VQL V R + ++ +I G+ L C V PPP I W T+
Sbjct: 1061 KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW--AKETQ 1118
Query: 2379 FSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYA 2438
+ P S ++ +GS I++T D+G Y C A N G + + V L + P I
Sbjct: 1119 LIS-PFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI-QRG 1176
Query: 2439 PGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGK-YILHDNGTLVIKEAT 2497
P +K G+ + + C + G P P I W+ ++ ++G+ ++ + +GTL I +AT
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTML----VDGEHHVSNPDGTLSIDQAT 1232
Query: 2498 AYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITN-RPPRSIVTRTGAA---FQLHCVAL 2553
D G Y C A N G T T + V PP + + PP + + A + C A
Sbjct: 1233 PSDAGIYTCVATNIAG-TDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAK 1291
Query: 2554 GVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
G PKP I W L R G L LVI + D+G Y C A N G+
Sbjct: 1292 GTPKPTIKWLHNGRELTG-----REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346
Score = 266 bits (681), Expect = 2e-70
Identities = 252/1004 (25%), Positives = 406/1004 (40%), Gaps = 80/1004 (7%)
Query: 1648 PRIVGGKAAS-FTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG 1706
P IVG + L CE GNP+P I W + D +++ ++ G
Sbjct: 2478 PHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK-----DGQPLQEDEAHHIISGG 2532
Query: 1707 T-LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRI---LERRTKEITVHSGST 1762
L I V++ G+Y C AS+ G +L+V P + +++TV S
Sbjct: 2533 RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSP 2592
Query: 1763 VELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVA 1822
L C A P T+TW + ES++ R ++ TL + N + G Y CVA
Sbjct: 2593 TSLVCEAYSYPPATITWFKDGTPL--ESNRNIR--ILPGGRTLQILNAQEDNAGRYSCVA 2648
Query: 1823 SNPGGQDSLLVKIQVIAAPPVILE--------QRRQVIVGTWGESLKLPCTAKGTPQPSV 1874
+N G+ +++V PP+I + ++V + +L L C A P S+
Sbjct: 2649 TNEAGEMIKHYEVKVYI-PPIINKGDLWGPGLSPKEVKIKV-NNTLTLECEAYAIPSASL 2706
Query: 1875 YWVLSDGTEVKPLQFTNSKLFLFSNG-TLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
W DG +K N + +NG TL I+ SD G Y C+A++ G + +
Sbjct: 2707 SWY-KDGQPLKSDDHVN----IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1934 MEERVTSPRI--------EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQ 1985
++ + ++ + + +V + + L C P P + W +
Sbjct: 2762 IQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSS 2821
Query: 1986 QHRVGSWIHVYPNGSLF-IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQ 2044
+ + P G + I +D+G Y CVA N+ G+D + V + + P
Sbjct: 2822 DK-----VLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANS 2876
Query: 2045 YFRKQV--LHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNG 2102
++V L K ++C +SGSP P SW DG + +D H+ L N
Sbjct: 2877 DLPEEVTVLVNKSALIECLSSGSPAPRNSWQ-KDGQPL-----LEDDHHKF----LSNGR 2926
Query: 2103 TLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLD 2162
L + + G Y C A+NT G + +L V P + N + + L
Sbjct: 2927 ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNV-HVPPSVIGPKSENLTVVVNNFISLT 2985
Query: 2163 CEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDD 2222
CEV+G P P + WL + I + + +L I + K+ D GEY C+A N +G+
Sbjct: 2986 CEVSGFPPPDLSWL-KNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGES 3044
Query: 2223 TKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLT 2282
K + L V P + + + +V+ + +C + P P + W +
Sbjct: 3045 KKKFSLTVYVPPSIKDHDSESLSVVNVR--EGTSVSLECESNAVPPPVITWYKNGRMITE 3102
Query: 2283 APYYGSRITVHKNGT-LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRN 2341
+ + + + +G L I+ +SD+ ++C A N G L V P+
Sbjct: 3103 STH----VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVP---PSIEG 3155
Query: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI-ISK 2400
P E IV + L C G PPP I W L N R N S + I S GS + I++
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAW-LKNHKRIENS-DSLEVRILSGGSKLQIAR 3213
Query: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL-TYAPGTVKGISGESLSLHCVSDGI 2459
+ D+G Y C A N G +K L I P + P V + GE++ L C ++GI
Sbjct: 3214 SQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGI 3273
Query: 2460 PKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITV 2519
P P I+W + G + + + + TL I A D G Y C A N G
Sbjct: 3274 PTPLIQW-LKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIF 3332
Query: 2520 PVMIVAYPPRITNRPP-RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERT 2578
+ + P N+ ++T + + C A G P P+I W + + L +S R
Sbjct: 3333 NLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW-LKNGLPLPLSSHIRL 3391
Query: 2579 HGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ Q+ + I Q SD +Y C A N G D +QV
Sbjct: 3392 LAAGQV-----IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV 3430
Score = 258 bits (660), Expect = 4e-68
Identities = 222/830 (26%), Positives = 353/830 (42%), Gaps = 83/830 (10%)
Query: 1805 LVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPC 1864
L + +++ D GFY+C+A + G V PPVI Q + T GE L C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVI--QVPNNVTVTPGERAVLTC 541
Query: 1865 TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG 1924
++ W +D +V+ + +++ +N +L ++++ +D G Y C+ +S G
Sbjct: 542 LIISAVDYNLTWQRND-RDVRLAE--PARIRTLANLSLELKSVKFNDAGEYHCMVSSEGG 598
Query: 1925 SERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVD 1984
S V LT++E P K G ++ + CSATG PKP+I W + +V
Sbjct: 599 SSAASVFLTVQE----PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 1985 QQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQ 2044
HR + +G+LFI + KD+G+Y C+A N G D + +LR A
Sbjct: 655 -SHR----YRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTD--KQNSTLRYIEAPKLMVV 707
Query: 2045 YFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNN--G 2102
V G ++CK SG P P++ W D + R + + + G
Sbjct: 708 QSELLVALGDITVMECKTSGIPPPQVKWFKGDLEL------------RPSTFLIIDPLLG 755
Query: 2103 TLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLD 2162
L + + GDYTC A N G+ K+ L V +P + + ++ G L
Sbjct: 756 LLKIQETQDLDAGDYTCVAINEAGRATGKITLDV--GSPPVFIQEPADVSMEIGSNVTLP 813
Query: 2163 CEVTGDPKPKIFWLLPSNDMI---SFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPS 2219
C V G P+P I W N I FS+ + G+L I + D G Y+C A N
Sbjct: 814 CYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQF 873
Query: 2220 GDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCR-AEGTPSPEVMWIMPDN 2278
G K+ V+ L+ L + A + + C G P PE WI
Sbjct: 874 G---KIQSETTVTVTGLVAPLIGISPSV-ANVIEGQQLTLPCTLLAGNPIPERRWIKNSA 929
Query: 2279 IFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPT 2338
+ L PY ITV +G+L I V+L D ++ CVA N G + + V + PT
Sbjct: 930 MLLQNPY----ITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVL---PT 982
Query: 2339 FRNPFNEKIVAQL-GKSTALNCSVDGNPPPEIIW------ILPNGTRFSNGPQSYQYLIA 2391
++ ++I++ + G L C GNP P +IW I + +FS G Y+++
Sbjct: 983 IQH--GQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVS 1040
Query: 2392 SNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL-------TYAPGTVKG 2444
G E++G+Y C A N GY ++ V L + +P + P +
Sbjct: 1041 PGG---------EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISV 1091
Query: 2445 ISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNY 2504
++GE ++L C +P P I W + + + ++ +G++ I E D G Y
Sbjct: 1092 LAGEEVTLPCEVKSLPPPIITWAKETQLI---SPFSPRHTFLPSGSMKITETRTSDSGMY 1148
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
+C A N G+ +T V + + P R P+ + + G + C A G P P ITW
Sbjct: 1149 LCVATNIAGN--VTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSK 1206
Query: 2565 PDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
++L ++ GTL I SD+GIY C A N G+D
Sbjct: 1207 GGSTMLVDGEHHVSNP------DGTLSIDQATPSDAGIYTCVATNIAGTD 1250
Score = 254 bits (649), Expect = 8e-67
Identities = 252/1018 (24%), Positives = 413/1018 (40%), Gaps = 102/1018 (10%)
Query: 1643 YIFEKPRIV-GGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQ 1701
++ E P + GK + T+ ++ L C+A GNP+P I W + D ++ +
Sbjct: 1914 HVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYK-----DNRLLSGSTSMT 1968
Query: 1702 VLPNGTL-SIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSG 1760
L G + I+ +I D G Y C A N G L +L V P + + V
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS--ISGSNNMVAVVVN 2026
Query: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKC 1820
+ V L+C A G P+P++TW L + + VS S G + V++ L L + I D G Y C
Sbjct: 2027 NPVRLECEARGIPAPSLTW-LKDGSPVSSFSNGLQ--VLSGGRILALTSAQISDTGRYTC 2083
Query: 1821 VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
VA N G+ + ++V P ++ E++ ++ + ++++L C + P P++ W L D
Sbjct: 2084 VAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLIS--QAVELLCQSDAIPPPTLTW-LKD 2140
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
G PL + L I + D G Y C AT+ G + +
Sbjct: 2141 G---HPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEK----NYNVNIWV 2193
Query: 1941 PRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVV-DQQHRVGSWIHVYP 1997
P S + T++ G+ + L C ++G P P ++W+ V+ D RV +
Sbjct: 2194 PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRV----RILS 2249
Query: 1998 NGSLFIGSVTEK-DSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVL-HGKD 2055
G S+ EK D+ +Y CVA N G ++ + ++P + + + ++ GK
Sbjct: 2250 GGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKS 2309
Query: 2056 FQVDCKASGSPVPEISWSLPDGTMINNAMQAD--DSGHRTRRYTLFNNGTLYFNKVGVAE 2113
++C+ G P P ++W + DG + A + D GH L + V++
Sbjct: 2310 ISLECEVQGIPPPTVTW-MKDGHPLIKAKGVEILDEGH-----------ILQLKNIHVSD 2357
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGD--TAVLDCEVTGDPKP 2171
G Y C A N G + K L+V A P I ++++ + I + + L CE +G P P
Sbjct: 2358 TGRYVCVAVNVAGMTDKKYDLSV-HAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLP 2416
Query: 2172 KIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVV 2231
I W +S S L + + + D+G+Y CV RN +G++ K++ L V+
Sbjct: 2417 SITWF-KDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVL 2475
Query: 2232 SKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRIT 2291
P ++ T+ C G P PE+ W +
Sbjct: 2476 VPPHIVG----ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH---I 2528
Query: 2292 VHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR------NPFNE 2345
+ L+I NV++ + + C+A + G L V PT NP E
Sbjct: 2529 ISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS---PTIAGVGSDGNP--E 2583
Query: 2346 KIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTRED 2405
+ L T+L C PP I W +GT + ++ + I ++
Sbjct: 2584 DVTVILNSPTSLVCEAYSYPPATITWF-KDGTPLESNRNIR--ILPGGRTLQILNAQEDN 2640
Query: 2406 AGKYRCAARNKVGYIEKLVILEIGQKPVILT-------YAPGTVKGISGESLSLHCVSDG 2458
AG+Y C A N+ G + K +++ P+I +P VK +L+L C +
Sbjct: 2641 AGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYA 2700
Query: 2459 IPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLIT 2518
IP ++ W + +N I + TL IKEA D G Y C A N G +
Sbjct: 2701 IPSASLSWYKDGQPLKSDDHVN---IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELD 2757
Query: 2519 VPVMIVAYPPRI-----------TNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDH 2567
V I PP T R + L+C P P +TW H
Sbjct: 2758 FDVNIQV-PPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGH 2816
Query: 2568 SLLSTASKERTHGSEQLHLQGTLVIQNPQTS--DSGIYKCTAKNPLGSDYAATYIQVI 2623
L S+ + L L G V+Q P+ D+G Y C A N G D ++V+
Sbjct: 2817 PLTSS--------DKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866
Score = 165 bits (418), Expect = 5e-40
Identities = 120/414 (28%), Positives = 184/414 (44%), Gaps = 33/414 (7%)
Query: 1658 FTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQD 1717
+T+ NS A LPC A G P P I+W + L K + P G L ++ V ++D
Sbjct: 4178 YTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAE----PYGELILENVVLED 4233
Query: 1718 RGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTV 1777
G Y C A+N G D V+L+V P +++++ G + L C+A G P P +
Sbjct: 4234 SGFYTCVANNAAGEDTHTVSLTVHVLPT--FTELPGDVSLNKGEQLRLSCKATGIPLPKL 4291
Query: 1778 TWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQV 1837
TW N + + V LV+ +S D G Y C A N G + + V
Sbjct: 4292 TWTFNNNIIPAHFDS------VNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYV 4345
Query: 1838 IAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLF 1897
PPV + G + L C KG P P++ W G +++ + ++
Sbjct: 4346 -KEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRK-GVDIE----ISHRIRQL 4399
Query: 1898 SNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGD 1957
NG+L I + D G Y C+AT+ G R + LT++ SP I T +N G
Sbjct: 4400 GNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQ----SPPIITLEPVETVINAGG 4455
Query: 1958 KLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW---IHVYPNGSLFIGSVTEKDSGVY 2014
K++LNC ATGEP+P I W ++ SW ++V N SL+I ++D+ +
Sbjct: 4456 KIILNCQATGEPQPTITWSRQGHSI--------SWDDRVNVLSNNSLYIADAQKEDTSEF 4507
Query: 2015 LCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVP 2068
CVARN MG L+ + V +++ + V GK Q + P+P
Sbjct: 4508 ECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLP 4561
Score = 165 bits (417), Expect = 6e-40
Identities = 140/517 (27%), Positives = 209/517 (40%), Gaps = 29/517 (5%)
Query: 2108 KVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTG 2167
KV +++EG Y C A ++ G + V P I+ N N + G+ AVL C +
Sbjct: 488 KVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPN--NVTVTPGERAVLTCLIIS 545
Query: 2168 DPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYK 2227
+ W D+ R AN SL + VK D+GEY C+ + G
Sbjct: 546 AVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF 605
Query: 2228 LDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYG 2287
L V +PP + + N++ + V C A G P P++ W + D +F+ +
Sbjct: 606 L-TVQEPPKVTVMPKNQSFTGGSEV-----SIMCSATGYPKPKIAWTVND-MFIVGSH-- 656
Query: 2288 SRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKI 2347
R + +GTL I+N D+ + C+A N G Q L + P +E +
Sbjct: 657 -RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTD---KQNSTLRYIEAPKLMVVQSELL 712
Query: 2348 VAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG 2407
VA LG T + C G PPP++ W + P ++ + G I +T DAG
Sbjct: 713 VA-LGDITVMECKTSGIPPPQVKWFKGD---LELRPSTFLIIDPLLGLLKIQETQDLDAG 768
Query: 2408 KYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW- 2466
Y C A N+ G + L++G PV + P V G +++L C G P+P IKW
Sbjct: 769 DYTCVAINEAGRATGKITLDVGSPPVFI-QEPADVSMEIGSNVTLPCYVQGYPEPTIKWR 827
Query: 2467 TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY 2526
+ + + RP G L I A D+G YIC+A+N G V +
Sbjct: 828 RLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGL 887
Query: 2527 PPRITNRPPRSIVTRTGAAFQLHCVAL-GVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
+ P G L C L G P PE W LL + +
Sbjct: 888 VAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ-------NPYITVR 940
Query: 2586 LQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G+L I+ Q D G Y C A N G++ T + V
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVV 977
Score = 137 bits (346), Expect = 1e-31
Identities = 118/448 (26%), Positives = 188/448 (41%), Gaps = 39/448 (8%)
Query: 2183 ISFSIDRYTFH-ANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLY 2241
++ +D+Y A+ +L I KV L D G Y C+A + +G DV PP+I
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVI---- 523
Query: 2242 TNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPD-NIFLTAPYYGSRITVHKNGTLEI 2300
+ T + C + W D ++ L P +RI N +LE+
Sbjct: 524 --QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEP---ARIRTLANLSLEL 578
Query: 2301 RNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCS 2360
++V+ +D+ ++ C+ +EGG S V L V E + P N+ G ++ CS
Sbjct: 579 KSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVM--PKNQSFTG--GSEVSIMCS 634
Query: 2361 VDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYI 2420
G P P+I W + F G S++Y + S+G+ I +DAG Y C A N G
Sbjct: 635 ATGYPKPKIAWTV--NDMFIVG--SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTD 690
Query: 2421 EKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW------TMPSGYVV 2474
++ L + P ++ + + G+ + C + GIP P +KW PS +++
Sbjct: 691 KQNSTLRYIEAPKLMVVQSELLVAL-GDITVMECKTSGIPPPQVKWFKGDLELRPSTFLI 749
Query: 2475 DRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRP 2534
P + G L I+E D G+Y C A N G T + + P + +
Sbjct: 750 IDPLL---------GLLKIQETQDLDAGDYTCVAINEAGRA--TGKITLDVGSPPVFIQE 798
Query: 2535 PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQN 2594
P + G+ L C G P+P I W D+ + S+ + S G L I N
Sbjct: 799 PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDN--MPIFSRPFSVSSISQLRTGALFILN 856
Query: 2595 PQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
SD G Y C A+N G + T + V
Sbjct: 857 LWASDKGTYICEAENQFGKIQSETTVTV 884
Score = 91.3 bits (225), Expect = 1e-17
Identities = 66/203 (32%), Positives = 101/203 (49%), Gaps = 28/203 (13%)
Query: 1643 YIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV 1702
Y+ E P G +++ P +A L CE G+P PTI W R G+D+ + + R++
Sbjct: 4344 YVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNR--KGVDI---EISHRIRQ 4398
Query: 1703 LPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L NG+L+I +D G Y C A+N G ++L++ S P I+ E +++G
Sbjct: 4399 LGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQS--PPIITLEPVETVINAGGK 4456
Query: 1763 VELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIY-------DR 1815
+ L C+A G P PT+TW S QG ++ D VL N S+Y D
Sbjct: 4457 IILNCQATGEPQPTITW----------SRQG--HSISWDDRVNVLSNNSLYIADAQKEDT 4504
Query: 1816 GFYKCVASNPGGQDSLLVKIQVI 1838
++CVA N G S+LV++ VI
Sbjct: 4505 SEFECVARNLMG--SVLVRVPVI 4525
Score = 86.3 bits (212), Expect = 4e-16
Identities = 61/191 (31%), Positives = 94/191 (49%), Gaps = 10/191 (5%)
Query: 474 MISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS 533
MI + T L V++ ++ L C G+P+P + WL DG V+A + I I+
Sbjct: 1640 MIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWL-KDGVPVKA-----NDNIRIEAG 1693
Query: 534 GK-LELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETL 591
GK LE+ A D G Y C++++ + Y + V V P +E E + V + L
Sbjct: 1694 GKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETS-YFIVMVNNLL 1752
Query: 592 DLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPS 651
+L CH TG P +I W+ G ++ + K +LN L I Q + G YRC+AAN +
Sbjct: 1753 ELDCHVTGSPPPTIMWLKDG-QLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTA 1811
Query: 652 GVDFLIFQVSV 662
G F+V+V
Sbjct: 1812 GDHKKEFEVTV 1822
Score = 77.4 bits (189), Expect = 2e-13
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 18/182 (9%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLL-------ADGSKVRAPYVSEDGRILIDKSGKLELQMA 541
+ V L C G P P + WL +D +VR ++ KL++ +
Sbjct: 3165 ISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVR----------ILSGGSKLQIARS 3214
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP 601
D+G Y CI+SN + Y +++ P A E +V +GE ++L C++ GIP
Sbjct: 3215 QHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIP 3274
Query: 602 DASISWVIPGNNVLY-QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV 660
I W+ G + ++ R + N TL I D G Y CVA NP+G + IF +
Sbjct: 3275 TPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNL 3334
Query: 661 SV 662
+V
Sbjct: 3335 NV 3336
Score = 75.1 bits (183), Expect = 8e-13
Identities = 57/190 (30%), Positives = 91/190 (47%), Gaps = 9/190 (4%)
Query: 475 ISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG 534
I+ + E V G ++ L C QG P P V W+ DG P + G ++D+
Sbjct: 2292 ITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWM-KDGH----PLIKAKGVEILDEGH 2346
Query: 535 KLELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDL 593
L+L+ DTG Y C++ N Y ++V P + + + +V ++ L
Sbjct: 2347 ILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSL 2406
Query: 594 PCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVAANPSG 652
C ++GIP SI+W G V +S ++L+ G LR++Q T +D G Y CV N +G
Sbjct: 2407 TCEASGIPLPSITWFKDGWPVSLSNS--VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAG 2464
Query: 653 VDFLIFQVSV 662
+ IF +SV
Sbjct: 2465 EERKIFGLSV 2474
Score = 74.7 bits (182), Expect = 1e-12
Identities = 53/173 (30%), Positives = 87/173 (50%), Gaps = 10/173 (5%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+E +VL G V L C + P P + W A +++ +P+ R SG +++
Sbjct: 1087 VEISVLAGEEVTLPCEVKSLPPPIITW--AKETQLISPF---SPRHTFLPSGSMKITETR 1141
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
+ D+G+Y C+++N A +T + + + Q H V +G+ +D+PC++ G P
Sbjct: 1142 TSDSGMYLCVATNI--AGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199
Query: 603 ASISWVIPGNNVLYQSSRDKKVLN-NGTLRILQVTPKDQGYYRCVAANPSGVD 654
I+W G+ +L + V N +GTL I Q TP D G Y CVA N +G D
Sbjct: 1200 PVITWSKGGSTMLVDG--EHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTD 1250
Score = 72.4 bits (176), Expect = 6e-12
Identities = 50/171 (29%), Positives = 83/171 (48%), Gaps = 7/171 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSF 544
+VL+G V L C G PTP + W L DG + + E RI + +G L + A +
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQW-LKDGKPIAS---GETERIRVSANGSTLNIYGALTS 3312
Query: 545 DTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
DTG Y C+++N + + + V V P + ++ + ++++ C +TG P
Sbjct: 3313 DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPP 3372
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
I+W+ G L SS + + +RI++ D Y CVA+N +GVD
Sbjct: 3373 QINWLKNG-LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVD 3422
Score = 70.1 bits (170), Expect = 3e-11
Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 8/172 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMAD 542
E TVL G + + C G P P + W L DG + D + + G L+L A+
Sbjct: 3444 EITVLKGSSTSMACITDGTPAPSMAW-LRDGQP-----LGLDAHLTVSTHGMVLQLLKAE 3497
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
+ D+G Y CI+SN + + V+EP E +V + L+L C ++GIP
Sbjct: 3498 TEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPA 3557
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
++W+ G L Q+ + + + LRI +D G Y C+A++P+G D
Sbjct: 3558 PKMTWMKDG-RPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD 3608
Score = 69.7 bits (169), Expect = 4e-11
Identities = 50/170 (29%), Positives = 75/170 (44%), Gaps = 10/170 (5%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG V + C QG P P + W SK + + + + + G L + A D
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITW-----SKGGSTMLVDGEHHVSNPDGTLSIDQATPSDA 1236
Query: 547 GVYHCISSNYDDADILTYRITVVE-PLVEAYQE--NGIHHTVFIGETLDLPCHSTGIPDA 603
G+Y C+++N D + V E P VE + N + ++ PC + G P
Sbjct: 1237 GIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKP 1296
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRIL-QVTPKDQGYYRCVAANPSG 652
+I W+ G L +L +GTL ++ VTP D G Y CVA N +G
Sbjct: 1297 TIKWLHNGRE-LTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAG 1345
Score = 68.9 bits (167), Expect = 6e-11
Identities = 45/168 (26%), Positives = 83/168 (49%), Gaps = 13/168 (7%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRI-LIDKSGKLELQMADSFD 545
V++ + L C G P+P + W + V+ GR + SG L++ A D
Sbjct: 3999 VILNNPILLPCEATGTPSPFITW------QKEGINVNTSGRNHAVLPSGGLQISRAVRED 4052
Query: 546 TGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C++ N + ++ V V P++ + + + + + + + L C + G+P
Sbjct: 4053 AGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE---YVIAVDKPITLSCEADGLPPPD 4109
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
I+W G ++ S ++VL++G+L+I V P D G+Y C+AAN +G
Sbjct: 4110 ITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155
Score = 68.6 bits (166), Expect = 8e-11
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 497 CPGQGDPTPHVDWLLADGSKV--RAPYVS--EDGRILIDKSGKLELQMADSFDTGVYHCI 552
CP +G P P + WL +G ++ R P +S EDG +L+ S +D G Y C+
Sbjct: 1288 CPAKGTPKPTIKWL-HNGRELTGREPGISILEDGTLLVIAS-------VTPYDNGEYICV 1339
Query: 553 SSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGN 612
+ N Y + V P V +E + +V + + +L C G P I W +
Sbjct: 1340 AVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY--KD 1397
Query: 613 NVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
NV S + +NNG L++ + TP+D G Y C A N +G F + V
Sbjct: 1398 NVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDV 1448
Score = 68.6 bits (166), Expect = 8e-11
Identities = 49/179 (27%), Positives = 83/179 (46%), Gaps = 8/179 (4%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
+L+ + L C +G PTP + W K A R I ++G L +Q A DT
Sbjct: 3724 ILLNKSTVLECIAEGVPTPRITW-----RKDGAVLAGNHARYSILENGFLHIQSAHVTDT 3778
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C+++N D RI + + + + TV + L C +TGIP SI+
Sbjct: 3779 GRYLCMATNAAGTD--RRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN 3836
Query: 607 WVIPGNNV-LYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKM 664
W G+ + + Q+ ++L++G+L I+ + D Y C N +G D ++V++
Sbjct: 3837 WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV 3895
Score = 67.4 bits (163), Expect = 2e-10
Identities = 53/179 (29%), Positives = 79/179 (44%), Gaps = 15/179 (8%)
Query: 478 DNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLE 537
D L TVLV V L C G+P P + W K +++ ++
Sbjct: 1923 DAGKMLNETVLVSNPVQLECKAAGNPVPVITWY-----KDNRLLSGSTSMTFLNRGQIID 1977
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCH 596
++ A D G+Y C++ N A L Y + V V P + N + V + + L C
Sbjct: 1978 IESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISG-SNNMV--AVVVNNPVRLECE 2034
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP---KDQGYYRCVAANPSG 652
+ GIP S++W+ G+ V S +VL+ G RIL +T D G Y CVA N +G
Sbjct: 2035 ARGIPAPSLTWLKDGSPVS-SFSNGLQVLSGG--RILALTSAQISDTGRYTCVAVNAAG 2090
Score = 67.4 bits (163), Expect = 2e-10
Identities = 54/173 (31%), Positives = 82/173 (47%), Gaps = 13/173 (7%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E+ + V + L+C G P P + W DG RA S R+L SG L++
Sbjct: 4087 EYVIAVDKPITLSCEADGLPPPDITWH-KDG---RAIVESIRQRVL--SSGSLQIAFVQP 4140
Query: 544 FDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
D G Y C+++N + + ++TV V P + + + H+TV LPC + GIP
Sbjct: 4141 GDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEG---HYTVNENSQAILPCVADGIPT 4197
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNN-GTLRILQVTPKDQGYYRCVAANPSGVD 654
+I+W +NVL + K G L + V +D G+Y CVA N +G D
Sbjct: 4198 PAINW--KKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGED 4248
Score = 66.2 bits (160), Expect = 4e-10
Identities = 48/188 (25%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKL 536
+ N + +VL+ + L C +G P P + W DG P +S + IDK L
Sbjct: 1549 KGGNVTTDISVLINSLIKLECETRGLPMPAITWY-KDGQ----PIMSSSQALYIDKGQYL 1603
Query: 537 ELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPC 595
+ A D+ Y C +N ++ + V V P++E ++ V I +L L C
Sbjct: 1604 HIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLEC 1663
Query: 596 HSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVD 654
+ G P ++W+ G V +++ + ++ G L I+ D+G Y CVA + +G
Sbjct: 1664 KAAGNPSPILTWLKDG--VPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEK 1721
Query: 655 FLIFQVSV 662
+ ++V V
Sbjct: 1722 EIKYEVDV 1729
Score = 66.2 bits (160), Expect = 4e-10
Identities = 48/168 (28%), Positives = 74/168 (44%), Gaps = 6/168 (3%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
+VL+ V L C P P + WL DG P + + G + + L+++ A D
Sbjct: 2114 SVLISQAVELLCQSDAIPPPTLTWL-KDGH----PLLKKPGLSISENRSVLKIEDAQVQD 2168
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
TG Y C ++N Y + + P + TV G + L C S+GIP ++
Sbjct: 2169 TGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNL 2228
Query: 606 SWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSG 652
W G+ VL S ++L+ G L+I D Y CVA+N +G
Sbjct: 2229 IWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAG 2276
Score = 65.5 bits (158), Expect = 7e-10
Identities = 44/148 (29%), Positives = 68/148 (45%), Gaps = 4/148 (2%)
Query: 507 VDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRI 566
VD+ L R ++E RI + LEL+ D G YHC+ S+ + + +
Sbjct: 547 VDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFL 606
Query: 567 TVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLN 626
TV EP T G + + C +TG P I+W + N++ S ++ +
Sbjct: 607 TVQEPPKVTVMPKNQSFTG--GSEVSIMCSATGYPKPKIAWTV--NDMFIVGSHRYRMTS 662
Query: 627 NGTLRILQVTPKDQGYYRCVAANPSGVD 654
+GTL I PKD G Y C+A+N +G D
Sbjct: 663 DGTLFIKNAAPKDAGIYGCLASNSAGTD 690
Score = 65.1 bits (157), Expect = 9e-10
Identities = 51/182 (28%), Positives = 78/182 (42%), Gaps = 11/182 (6%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E V+ V L C G P P + WL D P + G + I SG++ LQ+A +
Sbjct: 1835 ERVVVKYKPVALQCIANGIPNPSITWLKDD-----QPVNTAQGNLKIQSSGRV-LQIAKT 1888
Query: 544 F--DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP 601
D G Y C+++N ++ V EP ++ TV + + L C + G P
Sbjct: 1889 LLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNP 1948
Query: 602 DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP-KDQGYYRCVAANPSGVDFLIFQV 660
I+W +N L S LN G + ++ D G Y+CVA N +G L + +
Sbjct: 1949 VPVITWY--KDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSL 2006
Query: 661 SV 662
V
Sbjct: 2007 QV 2008
Score = 64.7 bits (156), Expect = 1e-09
Identities = 51/176 (28%), Positives = 81/176 (46%), Gaps = 22/176 (12%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSF 544
TVL V L C P P + WL +G +++A R+ I G+ L++ AD
Sbjct: 3632 TVLRNRQVTLECKSDAVPPPVITWL-RNGERLQAT-----PRVRILSGGRYLQINNADLG 3685
Query: 545 DTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
DT Y C++SN + +TV V P ++ ++ + + + ++ L C + G+P
Sbjct: 3686 DTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLV---ILLNKSTVLECIAEGVPTP 3742
Query: 604 SISW-----VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
I+W V+ GN+ Y +L NG L I D G Y C+A N +G D
Sbjct: 3743 RITWRKDGAVLAGNHARYS------ILENGFLHIQSAHVTDTGRYLCMATNAAGTD 3792
Score = 64.3 bits (155), Expect = 2e-09
Identities = 53/191 (27%), Positives = 83/191 (43%), Gaps = 20/191 (10%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E + V T+ L C P+ + W DG P S+D + L+++ A
Sbjct: 2683 EVKIKVNNTLTLECEAYAIPSASLSWY-KDGQ----PLKSDDHVNIAANGHTLQIKEAQI 2737
Query: 544 FDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQE---------NGIHHTVFIGETLDL 593
DTG Y C++SN D L + + + V P + E NG V I + L
Sbjct: 2738 SDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISL 2797
Query: 594 PCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG--TLRILQVTPKDQGYYRCVAANPS 651
C + P +++W G+ + +S DK ++ G L+I + +D G Y CVA N +
Sbjct: 2798 YCETNAAPPPTLTWYKDGHPL---TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA 2854
Query: 652 GVDFLIFQVSV 662
G D L + V V
Sbjct: 2855 GEDSLQYDVRV 2865
Score = 63.9 bits (154), Expect = 2e-09
Identities = 51/184 (27%), Positives = 81/184 (44%), Gaps = 15/184 (8%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSFDTGV 548
G +V L C P P + W ++E + I G+ L ++ A+ DTG
Sbjct: 3074 GTSVSLECESNAVPPPVITWYK------NGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127
Query: 549 YHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
Y C + N D + + V V P +E + I T I + L C +TGIP +I+W
Sbjct: 3128 YVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVET--ISNPVTLTCDATGIPPPTIAW 3185
Query: 608 VIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVAANPSG----VDFLIFQVSV 662
+ + S + ++L+ G+ L+I + D G Y C+A+N G FL QV
Sbjct: 3186 LKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPP 3245
Query: 663 KMKG 666
+ G
Sbjct: 3246 SVAG 3249
Score = 63.2 bits (152), Expect = 3e-09
Identities = 54/204 (26%), Positives = 90/204 (44%), Gaps = 14/204 (6%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V+V + L+C G P P + WL DG + DG ++ KL + A +T
Sbjct: 1746 VMVNNLLELDCHVTGSPPPTIMWL-KDGQLID----ERDGFKILLNGRKLVIAQAQVSNT 1800
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIG-ETLDLPCHSTGIPDASI 605
G+Y C+++N + +TV P + +G+ V + + + L C + GIP+ SI
Sbjct: 1801 GLYRCMAANTAGDHKKEFEVTVHVP--PTIKSSGLSERVVVKYKPVALQCIANGIPNPSI 1858
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK 665
+W+ V K + L+I + +D G Y CVA N +G Q +++
Sbjct: 1859 TWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGET----QQHIQLH 1914
Query: 666 GQRP--LEHDGETEGSGLDESNPI 687
P LE G+ + SNP+
Sbjct: 1915 VHEPPSLEDAGKMLNETVLVSNPV 1938
Score = 62.0 bits (149), Expect = 7e-09
Identities = 45/178 (25%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGV 548
+GG LNC +GDPTP + W + + RI +G L + + D G
Sbjct: 4363 LGGNAILNCEVKGDPTPTIQW------NRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGD 4416
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
Y C+++N + +T+ P + + + + G + L C +TG P +I+W
Sbjct: 4417 YTCVATNEAGVVERSMSLTLQSPPIITLEP--VETVINAGGKIILNCQATGEPQPTITWS 4474
Query: 609 IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKG 666
G+++ + VL+N +L I +D + CVA N G + V V++ G
Sbjct: 4475 RQGHSISWDDR--VNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHG 4530
Score = 61.6 bits (148), Expect = 1e-08
Identities = 50/178 (28%), Positives = 78/178 (43%), Gaps = 8/178 (4%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V++ + L C P P + W DG P S D +++ L++ A D
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWY-KDGH----PLTSSDKVLILPGGRVLQIPRAKVEDA 2843
Query: 547 GVYHCISSNYDDADILTYRITV-VEPLVE-AYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C++ N D L Y + V V P+++ A + TV + ++ + C S+G P
Sbjct: 2844 GRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPR 2903
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
SW G +L + K + N L+IL D G Y CVA N +G F ++V
Sbjct: 2904 NSWQKDGQPLL-EDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNV 2960
Score = 60.8 bits (146), Expect = 2e-08
Identities = 53/197 (26%), Positives = 86/197 (43%), Gaps = 14/197 (7%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKL 536
R +T+ +TV L C G PTP ++W K + G+ + G+L
Sbjct: 4170 RIRSTEGHYTVNENSQAILPCVADGIPTPAINW-----KKDNVLLANLLGKYTAEPYGEL 4224
Query: 537 ELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH 596
L+ D+G Y C+++N D T +TV ++ + E ++ GE L L C
Sbjct: 4225 ILENVVLEDSGFYTCVANNAAGEDTHTVSLTV--HVLPTFTELPGDVSLNKGEQLRLSCK 4282
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG---- 652
+TGIP ++W NN++ + V + L I +V+ +D G Y C A N G
Sbjct: 4283 ATGIPLPKLTWTF-NNNII--PAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKA 4339
Query: 653 VDFLIFQVSVKMKGQRP 669
+ F+ + KG P
Sbjct: 4340 IGFVYVKEPPVFKGDYP 4356
Score = 60.5 bits (145), Expect = 2e-08
Identities = 52/197 (26%), Positives = 87/197 (44%), Gaps = 15/197 (7%)
Query: 475 ISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG 534
+ D N + + TV++ L C P + W DG+ P S ++
Sbjct: 2576 VGSDGNPE-DVTVILNSPTSLVCEAYSYPPATITWF-KDGT----PLESNRNIRILPGGR 2629
Query: 535 KLELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHT-----VFIG 588
L++ A + G Y C+++N I Y + V + P++ G + + +
Sbjct: 2630 TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVN 2689
Query: 589 ETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVA 647
TL L C + IP AS+SW G + +S + NG TL+I + D G Y CVA
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPL--KSDDHVNIAANGHTLQIKEAQISDTGRYTCVA 2747
Query: 648 ANPSGVDFLIFQVSVKM 664
+N +G D L F V++++
Sbjct: 2748 SNIAGEDELDFDVNIQV 2764
Score = 58.9 bits (141), Expect = 6e-08
Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 10/172 (5%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E V +G + C G P P V W D + ++ D + G L++Q
Sbjct: 710 ELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL-----GLLKIQETQD 764
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
D G Y C++ N +A T +IT+ + + ++ IG + LPC+ G P+
Sbjct: 765 LDAGDYTCVAIN--EAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEP 822
Query: 604 SISWVIPGNNVLYQ---SSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W N ++ S L G L IL + D+G Y C A N G
Sbjct: 823 TIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874
Score = 58.5 bits (140), Expect = 8e-08
Identities = 47/194 (24%), Positives = 79/194 (40%), Gaps = 10/194 (5%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E TVLV + + C G P P W K P + +D + L++
Sbjct: 2881 EVTVLVNKSALIECLSSGSPAPRNSW-----QKDGQPLLEDDHHKFLSNGRILQILNTQI 2935
Query: 544 FDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
D G Y C++ N + + + V V P V + + TV + + L C +G P
Sbjct: 2936 TDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENL--TVVVNNFISLTCEVSGFPP 2993
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+SW + + ++ V TL+I++ D G Y C+A N +G F ++V
Sbjct: 2994 PDLSW-LKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052
Query: 663 KMKGQRPLEHDGET 676
+ +HD E+
Sbjct: 3053 YVPPSIK-DHDSES 3065
Score = 57.8 bits (138), Expect = 1e-07
Identities = 43/177 (24%), Positives = 72/177 (40%), Gaps = 7/177 (3%)
Query: 477 RDNNTKLEHTV-LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK 535
R N + E + LV ++ + C G P P ++WL K P L+
Sbjct: 3343 RGNKDEAEKLMTLVDTSINIECRATGTPPPQINWL-----KNGLPLPLSSHIRLLAAGQV 3397
Query: 536 LELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC 595
+ + A D VY C++SN D Y + V P TV G + + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 596 HSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ G P S++W+ G + + + L++L+ +D G Y C+A+N +G
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVST-HGMVLQLLKAETEDSGKYTCIASNEAG 3513
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/179 (25%), Positives = 73/179 (40%), Gaps = 5/179 (2%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E +V++ V L C +G P P + W DG + ++ + L+D+ L L+ A
Sbjct: 1462 EVSVVLNRDVALECQVKGTPFPDIHWF-KDGKPL---FLGDPNVELLDRGQVLHLKNARR 1517
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
D G Y C SN ++T+ P +V I + L C + G+P
Sbjct: 1518 NDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMP 1577
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+I+W G ++ SS+ + L I + D Y C AN +G F V V
Sbjct: 1578 AITWYKDGQPIM-SSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDV 1635
Score = 55.8 bits (133), Expect = 5e-07
Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 28/277 (10%)
Query: 409 PKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPV 468
P PE + A L +P ++ SL + R +Q + T + +
Sbjct: 918 PIPERRWIKNSAMLLQNPYITVRSDGSLHIER---------VQLQDGGEYTCVASNVAGT 968
Query: 469 KHKWTMISRDNNTKLEH-----TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVS 523
+K T + ++H + + G V L C G+P P V W SK +
Sbjct: 969 NNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIW-----SKKGELIST 1023
Query: 524 EDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEA-----YQ 577
+ G L + ++G Y C ++N ++TV V P V Q
Sbjct: 1024 SSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQ 1083
Query: 578 ENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP 637
+ + +V GE + LPC +P I+W ++ S L +G+++I +
Sbjct: 1084 DKPVEISVLAGEEVTLPCEVKSLPPPIITWA-KETQLISPFSPRHTFLPSGSMKITETRT 1142
Query: 638 KDQGYYRCVAANPSG--VDFLIFQVSVKMKGQRPLEH 672
D G Y CVA N +G + V V K QR +H
Sbjct: 1143 SDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKH 1179
Score = 55.8 bits (133), Expect = 5e-07
Identities = 48/172 (27%), Positives = 73/172 (42%), Gaps = 12/172 (6%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E +V+V + L C G P P + W+ K P D + L + A
Sbjct: 3537 EISVIVNNPLELTCIASGIPAPKMTWM-----KDGRPLPQTDQVQTLGGGEVLRISTAQV 3591
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
DTG Y C++S+ D Y + V P A + TV + L C S +P
Sbjct: 3592 EDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPP 3651
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQG---YYRCVAANPSG 652
I+W+ G + Q++ ++L+ G R LQ+ D G Y CVA+N +G
Sbjct: 3652 VITWLRNGERL--QATPRVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Score = 53.9 bits (128), Expect = 2e-06
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G V + C G P P + W + D ++ R + G L ++ A D G+Y
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVND------MFIVGSHRYRMTSDGTLFIKNAAPKDAGIY 679
Query: 550 HCISSNYDDADILTYRITVVE-PLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
C++SN D + +E P + Q + V +G+ + C ++GIP + W
Sbjct: 680 GCLASNSAGTDKQNSTLRYIEAPKLMVVQSELL---VALGDITVMECKTSGIPPPQVKW- 735
Query: 609 IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
G+ L S+ G L+I + D G Y CVA N +G
Sbjct: 736 FKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Score = 53.9 bits (128), Expect = 2e-06
Identities = 46/167 (27%), Positives = 68/167 (40%), Gaps = 6/167 (3%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV+V L C G P P ++W +G + R+L SG L + D
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSINWR-KNGHLLNVDQNQNSYRLL--SSGSLVIISPSVDD 3870
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
T Y C +N D T +TV P A + T + C ++G+P SI
Sbjct: 3871 TATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT--CTASGVPFPSI 3928
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
W G +L + ++L++G + IL G Y CVA N +G
Sbjct: 3929 HWTKNGIRLLPRGD-GYRILSSGAIEILATQLNHAGRYTCVARNAAG 3974
Score = 48.9 bits (115), Expect = 7e-05
Identities = 49/180 (27%), Positives = 77/180 (42%), Gaps = 12/180 (6%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSF 544
+V+ +V L C G P P + W DG V +S RIL G+ L L
Sbjct: 2397 SVVEKNSVSLTCEASGIPLPSITWF-KDGWPVS---LSNSVRIL--SGGRMLRLMQTTME 2450
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHT-VFIGETLDLPCHSTGIPDA 603
D G Y C+ N + + ++V+ P EN + V +++ L C TG P
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLVP-PHIVGENTLEDVKVKEKQSVTLTCEVTGNPVP 2509
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
I+W G + Q +++ G L+I V G Y C+A++P+G F ++V
Sbjct: 2510 EITWHKDGQPL--QEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Score = 46.2 bits (108), Expect = 4e-04
Identities = 45/169 (26%), Positives = 71/169 (42%), Gaps = 8/169 (4%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKV--RAPYVSEDGRILIDKSGKLELQMADSFDT 546
+G V L C QG P P + W D + R VS ++ ++G L + + D
Sbjct: 806 IGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQL---RTGALFILNLWASDK 862
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHS-TGIPDASI 605
G Y C + N +TV + + V G+ L LPC G P
Sbjct: 863 GTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPER 922
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
W+ N+ + + V ++G+L I +V +D G Y CVA+N +G +
Sbjct: 923 RWI--KNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTN 969
Score = 46.2 bits (108), Expect = 4e-04
Identities = 43/180 (23%), Positives = 70/180 (38%), Gaps = 9/180 (5%)
Query: 475 ISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG 534
+ +D +VL+ L C +G P+P + W + V+E I +G
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQ------VTESSTIQTVNNG 1413
Query: 535 K-LELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDL 593
K L+L A D G Y C + N + I V+ P +V + + L
Sbjct: 1414 KILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVAL 1473
Query: 594 PCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSG 652
C G P I W G L+ + ++L+ G L + D+G Y+C +N +G
Sbjct: 1474 ECQVKGTPFPDIHWFKDGKP-LFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAG 1532
Score = 38.1 bits (87), Expect = 0.12
Identities = 20/73 (27%), Positives = 33/73 (45%), Gaps = 6/73 (8%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+E + GG + LNC G+P P + W S +S D R+ + + L + A
Sbjct: 4447 VETVINAGGKIILNCQATGEPQPTITWSRQGHS------ISWDDRVNVLSNNSLYIADAQ 4500
Query: 543 SFDTGVYHCISSN 555
DT + C++ N
Sbjct: 4501 KEDTSEFECVARN 4513
Score = 33.1 bits (74), Expect = 3.7
Identities = 29/120 (24%), Positives = 44/120 (36%), Gaps = 2/120 (1%)
Query: 533 SGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLD 592
S L++ D G Y CI+ + V EP N + TV GE
Sbjct: 481 SVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNV--TVTPGERAV 538
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
L C D +++W +V + L N +L + V D G Y C+ ++ G
Sbjct: 539 LTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGG 598
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 299 bits (766), Expect = 2e-80
Identities = 279/994 (28%), Positives = 421/994 (42%), Gaps = 101/994 (10%)
Query: 1648 PRI-VGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR--VPSGLDLSKRKQNSRVQVLP 1704
PRI G A + + L CEA G P P + W + P G D+ + L
Sbjct: 2025 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF----YLD 2080
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHS--GST 1762
G+L ++ + D G Y C A N G D T++V+ PP I + T+ S G
Sbjct: 2081 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL-VPPTIKQGADGSGTLVSRPGEL 2139
Query: 1763 VELKCRAEGRPSPTVTWI-------LANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR 1815
V + C G P V+W+ L+ +T++ S TL + + + D
Sbjct: 2140 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH-----------TLRISKVQLADA 2188
Query: 1816 GFYKCVASNPGGQDSLLVKIQVIAAPPVI--LEQRRQVIVGTWGESLKLPCTAKGTPQPS 1873
G + CVA++P G +QV PPV+ +E + V+V G ++LPC A+G P P
Sbjct: 2189 GIFTCVAASPAGVADRNFTLQV-QVPPVLEPVEFQNDVVV-VRGSLVELPCEARGVPLPL 2246
Query: 1874 VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
V W + DG +PL + L +L + + + D GTY C+A S G RR LT
Sbjct: 2247 VSW-MKDG---EPLLSQS----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2298
Query: 1934 MEERVTSPRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGS 1991
+ E P IE + Q TE++ G + L C A G P+P I W H+ G
Sbjct: 2299 VME---PPHIEDSGQP-TELSLTPGAPMELLCDAQGTPQPNITW-----------HKDGQ 2343
Query: 1992 WIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVL 2051
+ N S + +D+G+Y C+A + G V ++ P + + L
Sbjct: 2344 ALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 2403
Query: 2052 HGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGV 2111
++C P P+I+W DG + +Q D R L +
Sbjct: 2404 APGQLVLECSVEAEPAPKITWH-RDGIV----LQEDAHTQFPER-----GRFLQLQALST 2453
Query: 2112 AEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKP 2171
A+ GDY+C A+N G + + + T P IR S + TA+L C+ G P P
Sbjct: 2454 ADSGDYSCTARNAAGSTSVAFRVEIHT-VPTIR-SGPPAVNVSVNQTALLPCQADGVPAP 2511
Query: 2172 KIFWLLPSNDMISFS--IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLD 2229
+ W D + R+ GSL I V D+G Y+C+A N +G D + L
Sbjct: 2512 LVSW---RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR 2568
Query: 2230 VVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
V+ +PP I +N T+ H+ C A G+P P V+W D L
Sbjct: 2569 VL-EPPAIAPSPSNLTL-----TAHTPALLPCEASGSPKPLVVW-WKDGQKLDFRLQQGA 2621
Query: 2290 ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVA 2349
+ + L + DSA F CV NE GE+ + Q+ V PT + + V
Sbjct: 2622 YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIADDQTDFTVT 2678
Query: 2350 QLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKY 2409
+ L C G P P + W + G + Y ++ +G+ I + AG+Y
Sbjct: 2679 MMA-PVVLTCHSTGIPAPTVSW---SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2734
Query: 2410 RCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP 2469
C+ARN G K V L + PV+ P V+ ++ E + L C + GIP+P I W
Sbjct: 2735 TCSARNSAGVAHKHVFLTVQASPVVKP-LPSVVRAVAEEEVLLPCEASGIPRPTITWQKE 2793
Query: 2470 SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
V + G L I A+ D GNY+C A+NS G + ++V PP
Sbjct: 2794 GLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR-LVVQVPPV 2848
Query: 2530 ITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT 2589
I N P T AF L C A G P+P ITW+ D +S A G + G
Sbjct: 2849 IENGLPDLSTTEGSHAF-LPCKARGSPEPNITWD-KDGQPVSGA-----EGKFTIQPSGE 2901
Query: 2590 LVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L+++N + D+G Y CTA+N +G ++ ++
Sbjct: 2902 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL 2935
Score = 298 bits (763), Expect = 5e-80
Identities = 257/994 (25%), Positives = 427/994 (42%), Gaps = 103/994 (10%)
Query: 1644 IFEKPRIV-GGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV 1702
+ E P I G+ ++ + L C+A G P P I W + G L++ + NSR
Sbjct: 2299 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK--DGQALTRLENNSR--- 2353
Query: 1703 LPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
+ + + ++D G Y C A + G + V + P + R + + +
Sbjct: 2354 ------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ 2407
Query: 1763 VELKCRAEGRPSPTVTW----ILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFY 1818
+ L+C E P+P +TW I+ + ++ + R L L LS D G Y
Sbjct: 2408 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGR--------FLQLQALSTADSGDY 2459
Query: 1819 KCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVL 1878
C A N G S+ ++++ P + + + ++ LPC A G P P V W
Sbjct: 2460 SCTARNAAGSTSVAFRVEIHTVPTI--RSGPPAVNVSVNQTALLPCQADGVPAPLVSW-- 2515
Query: 1879 SDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
+ PL + + + G+L I+ + + D G Y C+A++S GS+R+ + RV
Sbjct: 2516 --RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQ----GRDLRV 2569
Query: 1939 TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN 1998
P A S + LL C A+G PKP ++W + + D + + G++ + P+
Sbjct: 2570 LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKL-DFRLQQGAY-RLLPS 2627
Query: 1999 GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQV 2058
+L + + +DS + CV N++G+ L V++ + P D + F ++ +
Sbjct: 2628 NALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMM--APVVL 2685
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
C ++G P P +SWS + G R Y + +G L + G YT
Sbjct: 2686 TCHSTGIPAPTVSWSKAGAQL----------GARGSGYRVSPSGALEIGQALPIHAGRYT 2735
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A+N+ G V LTV A+P ++ + + A + +L CE +G P+P I W
Sbjct: 2736 CSARNSAGVAHKHVFLTV-QASPVVKPLPSVVRAV-AEEEVLLPCEASGIPRPTITWQKE 2793
Query: 2179 SNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI- 2237
++ + + G L I D+G Y+C+A+N +G +L VV PP+I
Sbjct: 2794 GLNVATGVSTQVL--PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL-VVQVPPVIE 2850
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGS--RITVHKN 2295
NGL T S C+A G+P P + W P G+ + T+ +
Sbjct: 2851 NGLPDLSTT------EGSHAFLPCKARGSPEPNITWDKDGQ-----PVSGAEGKFTIQPS 2899
Query: 2296 GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKST 2355
G L ++N+ D+ + C A N G + V L +L + P F ++ + +LG
Sbjct: 2900 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSL-RLGDRL 2955
Query: 2356 ALNCSVDGNPPPEIIWILPN-----GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYR 2410
L C+ G+P P I W + + G +G + Q S RED+G Y
Sbjct: 2956 WLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS----------REDSGTYV 3005
Query: 2411 CAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPS 2470
C A N+VG + + + + + PV+ A + G S+ L CV G P P+I W
Sbjct: 3006 CWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW---- 3061
Query: 2471 GYVVDRPQINGKYILHD--NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPP 2528
+ D + G ++ H NG+L I D G Y C A+N +G V +++ + P
Sbjct: 3062 --IKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP- 3118
Query: 2529 RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQG 2588
+ P+ + R+G L C A G P P I W L R + G
Sbjct: 3119 -VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-------LQAGQPLRASRRLRTLPDG 3170
Query: 2589 TLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+L ++N +T D+G Y C A N LGS A ++ V
Sbjct: 3171 SLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3204
Score = 278 bits (711), Expect = 5e-74
Identities = 261/962 (27%), Positives = 387/962 (40%), Gaps = 91/962 (9%)
Query: 1670 CEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG---TLSIQRVEIQDRGQYLCSAS 1726
C G+P + W + L LS+R L +G TL I +V++ D G + C A+
Sbjct: 2144 CPVRGSPPIHVSWLKDGLPLPLSQR-------TLLHGSGHTLRISKVQLADAGIFTCVAA 2196
Query: 1727 NLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV 1786
+ G + TL V P ++ V GS VEL C A G P P V+W+ + +
Sbjct: 2197 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 2256
Query: 1787 VSES-SQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVIL 1845
+S+S QG +L L + D G Y CVA + G+ ++ V+ P +
Sbjct: 2257 LSQSLEQGP---------SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED 2307
Query: 1846 EQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIR 1905
+ + T G ++L C A+GTPQP++ W DG + L+ N + R
Sbjct: 2308 SGQPTELSLTPGAPMELLCDAQGTPQPNITWH-KDGQALTRLE----------NNSRATR 2356
Query: 1906 NLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGD-KLLLNCS 1964
L D G Y C+A S G+ + + ++ P I R V +L+L CS
Sbjct: 2357 VLRVRDAGLYTCLAESPAGAIEKSFRVRVQ---APPNIVGPRGPRFVVGLAPGQLVLECS 2413
Query: 1965 ATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIG--SVTEKDSGVYLCVARNKM 2022
EP P+I W + + H +P F+ +++ DSG Y C ARN
Sbjct: 2414 VEAEPAPKITWHRDGIVLQEDAHTQ------FPERGRFLQLQALSTADSGDYSCTARNAA 2467
Query: 2023 GDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINN 2082
G + V + P V + + C+A G P P +SW +
Sbjct: 2468 GSTSVAFRVEIHTVPTIRSGPPAVNVSV--NQTALLPCQADGVPAPLVSWR-------KD 2518
Query: 2083 AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPR 2142
+ D R+ R+ + G+L V + G Y C A N+ G D L V+ P
Sbjct: 2519 RVPLDP---RSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-PA 2574
Query: 2143 IRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDR--YTFHANGSLTI 2200
I S +N + A A+L CE +G PKP + W + F + + Y + +L +
Sbjct: 2575 IAPS-PSNLTLTAHTPALLPCEASGSPKPLVVWW-KDGQKLDFRLQQGAYRLLPSNALLL 2632
Query: 2201 NKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFD 2260
DS ++ CV N G+ ++Y++ V PP I T+ TV V
Sbjct: 2633 TAPGPQDSAQFECVVSNEVGEAHRLYQV-TVHVPPTIADDQTDFTVTMMAPVV-----LT 2686
Query: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG 2320
C + G P+P V W GS V +G LEI + + C ARN G
Sbjct: 2687 CHSTGIPAPTVSW---SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG 2743
Query: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS 2380
V V ++ P + A + L C G P P I W G +
Sbjct: 2744 ----VAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW-QKEGLNVA 2798
Query: 2381 NGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPG 2440
G + + G I+ + EDAG Y C A+N G L + PVI P
Sbjct: 2799 TGVSTQ---VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD 2855
Query: 2441 TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD 2500
+ G L C + G P+PNI W G V + GK+ + +G L++K D
Sbjct: 2856 -LSTTEGSHAFLPCKARGSPEPNITWDK-DGQPVSGAE--GKFTIQPSGELLVKNLEGQD 2911
Query: 2501 RGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEI 2560
G Y C A+N+VG V + I+ P T RS+ R G L C A G P P I
Sbjct: 2912 AGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL--RLGDRLWLRCAARGSPTPRI 2969
Query: 2561 TWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYI 2620
W + D + S E+ GS TL DSG Y C A+N +G A +++
Sbjct: 2970 GWTVNDRPVTEGVS-EQDGGS-------TLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 3021
Query: 2621 QV 2622
V
Sbjct: 3022 HV 3023
Score = 276 bits (705), Expect = 3e-73
Identities = 255/929 (27%), Positives = 395/929 (42%), Gaps = 81/929 (8%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L I++V+++D G Y C+A+NL G V L V+ PP I E V ++V L+C
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNI-EPGPVNKAVLENASVTLEC 716
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG-TLVLHNLSIYDRGFYKCVASNPG 1826
A G P P V+W +Q V S V+VDG L + + D G Y+CVASN
Sbjct: 717 LASGVPPPDVSWFKGHQPVSSWMG-----VTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 771
Query: 1827 GQDSLLVKIQVIAAPPVILEQR--RQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G L ++V P + L V+V T ++L C A G P P++ W L DG V
Sbjct: 772 GSTELRYGLRVNVPPRITLPPSLPGPVLVNT---PVRLTCNATGAPSPTLMW-LKDGNPV 827
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
P ++F L + + +SD G Y C+A S+ G +R+ V+L +V P
Sbjct: 828 SPAGTPGLQVFP-GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL----QVHMPPSI 882
Query: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF-I 2003
+ V + + L C + P P + W + + + R G +H+ + +L +
Sbjct: 883 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL---EPRPG--VHLSADKALLQV 937
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKAS 2063
D+G Y C A N+ G ++++ + P ++ V G + C+
Sbjct: 938 DRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPV-FPLRESHTLTVREGHPTSLSCECR 996
Query: 2064 GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQN 2123
G P P+ISW DG + + +G ++ LY + +A+EG YTC N
Sbjct: 997 GVPFPKISWR-KDG----QPLPGEGAG---LQHVSAVGRLLYLGQAQLAQEGTYTCECSN 1048
Query: 2124 TLGKD----EMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPS 2179
+G +++VH+ A PR T + A L+C TG P P + W
Sbjct: 1049 VVGNSSQDLQLEVHVPPQIAGPR---EPPTQVSVVQDGVATLECNATGKPPPTVTW-ERD 1104
Query: 2180 NDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLING 2239
+ + + SL + + + +G Y CVA N +G + ++L V+ P LI
Sbjct: 1105 GQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD 1164
Query: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG--T 2297
L + TA HS C A G P P + W + P T G
Sbjct: 1165 L---DPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEE-----PVSPGEDTYLLAGGWM 1216
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQL-GKSTA 2356
L++ + DS + C+A NE GE+ +EVL P+ N E+++ L G++
Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV---PPSIENEDLEEVIKVLDGQTAH 1273
Query: 2357 LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI-ISKTTREDAGKYRCAARN 2415
L C+V G+P P++ W +G + G + I+ +G + + + AG Y C A N
Sbjct: 1274 LMCNVTGHPQPKLTW-FKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAAN 1329
Query: 2416 KVGYIEKLVILEIGQKPVILTYAPGT----VKGISGESLSLHCVSDGIPKPNIKWTMPSG 2471
VG K L + P IL A + V +SL C + P PNI W M G
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MKDG 1388
Query: 2472 YVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRIT 2531
+ + +L L I A D G Y C N +G + V ++ PP I+
Sbjct: 1389 APFEASR--NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPPSIS 1445
Query: 2532 NRPP------RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
P + + T+ + L C + VP P I W D ++ +S+ + G +L
Sbjct: 1446 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-YKDGQPVTPSSRLQVLGEGRL- 1503
Query: 2586 LQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
L IQ Q SDSG Y C A N G D
Sbjct: 1504 ----LQIQPTQVSDSGRYLCVATNVAGED 1528
Score = 268 bits (685), Expect = 5e-71
Identities = 254/1005 (25%), Positives = 404/1005 (40%), Gaps = 104/1005 (10%)
Query: 1648 PRIVGGKAASFTIPANSD--AFLPCEAVGNPLPTIHWTR--VPSGLDLSKRKQNSRVQVL 1703
P+I G + + D A L C A G P PT+ W R P G +L + QN
Sbjct: 1065 PQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ----- 1119
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRI--LERRTKEITVHSGS 1761
+L ++R + G+Y C A NL G LSV+ P I L+ T IT S
Sbjct: 1120 -GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN-ITAALHS 1177
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
+ L C A G P P + W + V S G ++ L + D G Y C+
Sbjct: 1178 PLTLLCEAMGIPPPAIRWFRGEEPV----SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCL 1233
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
ASN G+ ++V+ P + E +VI G++ L C G PQP + W DG
Sbjct: 1234 ASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW-FKDG 1292
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
+PL ++ L + S G Y CIA ++ G + + L++ + +P
Sbjct: 1293 ---RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV---LLAP 1346
Query: 1942 RI----EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
I E ++ + V + + L C A P P I W ++ I + P
Sbjct: 1347 TILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRN-----IQLLP 1401
Query: 1998 -NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA--------KIDHKQYFRK 2048
L I + ++D+G Y CV N++G+ + HV + + P+ ++ K+ K
Sbjct: 1402 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTK 1461
Query: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
++C++ P P I W DG + + +R L L
Sbjct: 1462 V---NSTLTLECESWAVPPPTIRW-YKDGQPVTPS---------SRLQVLGEGRLLQIQP 1508
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHL------------------TVITAAPRIRQSNKTN 2150
V++ G Y C A N G+D+ ++ +++ R
Sbjct: 1509 TQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEY 1568
Query: 2151 KRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGE 2210
+ I + A L C+ P P + W + +S + L I V+ ++G
Sbjct: 1569 REIVENNPAYLYCDTNAIPPPDLTW-YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR 1627
Query: 2211 YVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
Y C A N G+D Y+L +V PP+I G T V + T S C A G P P
Sbjct: 1628 YSCKASNEVGEDWLHYEL-LVLTPPVILG-DTEELVEEVTVNASSTVSLQCPALGNPVPT 1685
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNG-TLEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
+ W+ F +P R+ V ++G L++ ++D+A ++CVA N+ G + +L
Sbjct: 1686 ISWLQNGLPFSPSP----RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA---EKLF 1738
Query: 2330 VLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL 2389
L + P E++ A L S +L C V +P PE+ W + S G + +L
Sbjct: 1739 TLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW-YKDSQALSLGEE--VFL 1795
Query: 2390 IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGI---S 2446
+ + + + D+G Y C A N G +KLV L + P G +
Sbjct: 1796 LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV 1855
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRGNY 2504
G+ L C +D +P+P + W Y +P + + L L I+EA D+G Y
Sbjct: 1856 GDKAVLSCETDALPEPTVTW-----YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY 1910
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
CK N G + T + V PP N ++ G+ L C GVP P +TW
Sbjct: 1911 SCKVSNVAGEAVRTF-TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK 1969
Query: 2565 PDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
+ S+A HG + G L + Q + +G Y C A+N
Sbjct: 1970 DRMPVESSA----VHG--VVSRGGRLQLSRLQPAQAGTYTCVAEN 2008
Score = 259 bits (662), Expect = 2e-68
Identities = 251/1020 (24%), Positives = 397/1020 (38%), Gaps = 105/1020 (10%)
Query: 1648 PRIVGG--KAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
P ++G + T +S L CEA+G P P I W R + +L
Sbjct: 1159 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS-----PGEDTYLLAG 1213
Query: 1706 G-TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKE-ITVHSGSTV 1763
G L + + + QD G Y C ASN G + ++ V+ PP I +E I V G T
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL-VPPSIENEDLEEVIKVLDGQTA 1272
Query: 1764 ELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV-LHNLSIYDRGFYKCVA 1822
L C G P P +TW + + + ++ DG L+ + ++ G Y C+A
Sbjct: 1273 HLMCNVTGHPQPKLTWFKDGRPLARGDAHH-----ISPDGVLLQVLQANLSSAGHYSCIA 1327
Query: 1823 SNPGGQDSLLVKIQVIAAPPVI---LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLS 1879
+N G+ + ++ V+ AP ++ + + + T + L C A P P++ W +
Sbjct: 1328 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MK 1386
Query: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERR---VVMLTMEE 1936
DG P + + + L L I N D G Y C+ T+ G + V +L
Sbjct: 1387 DGA---PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443
Query: 1937 RVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVY 1996
+ K + L L C + P P I W + V S + V
Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-----SRLQVL 1498
Query: 1997 PNGSLFIGSVTE-KDSGVYLCVARNKMGDDLILMHVSLRLKPA--KI-DHKQYFR----- 2047
G L T+ DSG YLCVA N G+D +V +++ P K+ D F
Sbjct: 1499 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 1558
Query: 2048 ----------KQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYT 2097
++++ + C + P P+++W D + + G R +
Sbjct: 1559 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIP 1618
Query: 2098 LFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI--KA 2155
L V G Y+C A N +G+D + L V+T + + + + + A
Sbjct: 1619 L----------VRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNA 1668
Query: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCV 2214
T L C G+P P I WL N + R +G L ++ ++ D+ Y+CV
Sbjct: 1669 SSTVSLQCPALGNPVPTISWL--QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCV 1726
Query: 2215 ARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWI 2274
A N +G K++ L V PP I GL + + TA+ +S C P+PEV W
Sbjct: 1727 AENQAGSAEKLFTLRV-QVPPRIAGL----DLEQVTAILNSSVSLPCDVHAHPNPEVTWY 1781
Query: 2275 MPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEML 2334
H TL++ RLSDS + C A N G +VQL VL
Sbjct: 1782 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVP- 1837
Query: 2335 RRPTFRNPFN---EKIVAQLGKSTALNCSVDGNPPPEIIW-------ILPNGTRFSNGPQ 2384
P FR + ++ ++G L+C D P P + W +L T+ G Q
Sbjct: 1838 --PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1895
Query: 2385 SYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKG 2444
+ I + D G Y C N G + L + P TV
Sbjct: 1896 RLE----------IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ 1945
Query: 2445 ISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNY 2504
++G L L C G+P P + W + V+ ++G ++ G L + G Y
Sbjct: 1946 VAGSPLVLTCDVSGVPAPTVTW-LKDRMPVESSAVHG--VVSRGGRLQLSRLQPAQAGTY 2002
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
C A+N+ V ++ P ++ R G +L C A G P P++ W +
Sbjct: 2003 TCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-L 2061
Query: 2565 PDHSLLSTASKERTHGSEQLHLQ-GTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
D S L + +L G+LV++ + SD+G Y C A NP G D + V+
Sbjct: 2062 KDGSPLGQDMGPHL----RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL 2117
Score = 248 bits (633), Expect = 6e-65
Identities = 258/994 (25%), Positives = 389/994 (39%), Gaps = 93/994 (9%)
Query: 1648 PRIVGGKAASFTIP-ANSDAFLPCEAVGNPLPTIHWTR-----VPSGLDLSKRKQNSRVQ 1701
P ++G AA + A +D L C G P P + WT+ +P G L ++
Sbjct: 216 PSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ--- 272
Query: 1702 VLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGS 1761
L I + D G+Y C A + G L V + P T E+ V
Sbjct: 273 -----VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH 327
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG-TLVLHNLSIYDRGFYKC 1820
V+L C A G P+P +TW + + S + V T G L L D G Y C
Sbjct: 328 LVQLLCEARGVPTPNITWFKDGALLPT-----STKVVYTRGGRQLQLGRAQSSDAGVYTC 382
Query: 1821 VASNPGGQDSLLVKIQVIAAPPVI--LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVL 1878
ASN G ++ V PP I R V+ G + L C A+G P P++ W
Sbjct: 383 KASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW-- 439
Query: 1879 SDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
E P+ +N L + + + G Y C+A+S G V+ ++E +V
Sbjct: 440 --HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG--EAVLQYSVEVQV 495
Query: 1939 TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN 1998
+ A + G L L C A+G P P I W + + + + V
Sbjct: 496 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEEL-----AGVQVASQ 550
Query: 1999 G-SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA----KIDHKQYFRKQVLHG 2053
G +L I V SG++ C A N+ G + VS+ + A ++ QY G
Sbjct: 551 GTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH-----WG 605
Query: 2054 KDFQVDCKASGSPVPEISWS------LPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFN 2107
+ A+ P W L +G ++ + +G Y+L L
Sbjct: 606 XEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-AYSL--PPPLQIE 662
Query: 2108 KVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTG 2167
KV + +EG YTC A N G+ + +V L V+ P + NK + + L+C +G
Sbjct: 663 KVDLRDEGIYTCAATNLAGESKREVALKVL--VPPNIEPGPVNKAVLENASVTLECLASG 720
Query: 2168 DPKPKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDDTKMY 2226
P P + W + S+ T +G L I + +L D+G Y CVA N +G Y
Sbjct: 721 VPPPDVSWFKGHQPVSSWM--GVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 778
Query: 2227 KLDV-----VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFL 2281
L V ++ PP + G T ++ T C A G PSP +MW+ N
Sbjct: 779 GLRVNVPPRITLPPSLPGPVLVNTPVRLT----------CNATGAPSPTLMWLKDGNPVS 828
Query: 2282 TAPYYGSRITVHKNG-TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
A G + V G L + + R SDS + CVA + GE V L+V +
Sbjct: 829 PAGTPG--LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILG 884
Query: 2341 NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
N +VA +S AL C PPP + W +G P+ +L A + +
Sbjct: 885 EELNVSVVA--NESVALECQSHAMPPPVLSW-WKDGRPLE--PRPGVHLSADKALLQVDR 939
Query: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIP 2460
DAG Y C A N+ G EK L + PV T+ G SL C G+P
Sbjct: 940 ADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP 999
Query: 2461 KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVP 2520
P I W G + +++ L + +A G Y C+ N VG++ +
Sbjct: 1000 FPKISW-RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 1058
Query: 2521 VMIVAYPPRIT--NRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERT 2578
+ V PP+I PP + L C A G P P +TWE + + +
Sbjct: 1059 -LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQ 1117
Query: 2579 HGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
+ + LH ++ Q + +G Y C A+N G
Sbjct: 1118 NQGQSLH------VERAQAAHTGRYSCVAENLAG 1145
Score = 246 bits (629), Expect = 2e-64
Identities = 251/990 (25%), Positives = 392/990 (39%), Gaps = 95/990 (9%)
Query: 1663 NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYL 1722
N+ L C A G P P + W + G V V L I++ ++ D G Y
Sbjct: 709 NASVTLECLASGVPPPDVSWFK---GHQPVSSWMGVTVSV-DGRVLRIEQAQLSDAGSYR 764
Query: 1723 CSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILA 1782
C ASN+ G+ L L V+ PPRI + V + V L C A G PSPT+ W+
Sbjct: 765 CVASNVAGSTELRYGLR-VNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKD 823
Query: 1783 NQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP 1842
V + G + V L L + D G Y CVA + G+D V +QV P
Sbjct: 824 GNPVSPAGTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 881
Query: 1843 VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTL 1902
++ E+ +V ES+ L C + P P + W DG +PL+ L
Sbjct: 882 ILGEELNVSVVA--NESVALECQSHAMPPPVLSW-WKDG---RPLEPRPGVHLSADKALL 935
Query: 1903 YIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLN 1962
+ D G Y C A + G + L + +P V G L+
Sbjct: 936 QVDRADVWDAGHYTCEALNQAGRSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLS 992
Query: 1963 CSATGEPKPQIMWRLPSKAVVDQQHRVGSWI-HVYPNGS-LFIGSVTEKDSGVYLCVARN 2020
C G P P+I WR + + + G+ + HV G L++G G Y C N
Sbjct: 993 CECRGVPFPKISWRKDGQPLPGE----GAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN 1048
Query: 2021 KMGDDLILMHVSLRLKPAKIDHKQ-YFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTM 2079
+G+ + + + + P ++ + V+ ++C A+G P P ++W DG
Sbjct: 1049 VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE-RDGQP 1107
Query: 2080 INN--AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVI 2137
+ +Q + G +L+ + A G Y+C A+N G+ E K L+V+
Sbjct: 1108 VGAELGLQLQNQGQ-----------SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL 1156
Query: 2138 TAAPRIRQSNK-TNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
I + TN L CE G P P I W + +S D Y
Sbjct: 1157 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW-FRGEEPVSPGEDTYLLAGGW 1215
Query: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
L + + + DSG Y C+A N +G+ + + ++V+ P + N VIK +
Sbjct: 1216 MLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIK--VLDGQT 1271
Query: 2257 KHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT-LEIRNVRLSDSADFICVA 2315
H C G P P++ W G + +G L++ LS + + C+A
Sbjct: 1272 AHLMCNVTGHPQPKLTWFKDGRPLAR----GDAHHISPDGVLLQVLQANLSSAGHYSCIA 1327
Query: 2316 RNEGGESVLVVQLEVLEMLRRPTF----RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIW 2371
N GE QL V L PT + +E++ + +L C P P I W
Sbjct: 1328 ANAVGEKTKHFQLSV---LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW 1384
Query: 2372 ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG------YIEKLVI 2425
+ +G F ++ Q L ++G I++ +EDAG+Y C N++G ++E L+
Sbjct: 1385 -MKDGAPF-EASRNIQLLPGTHGLQILN-AQKEDAGQYTCVVTNELGEAVKNYHVEVLIP 1441
Query: 2426 LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYIL 2485
I + + VK +L+L C S +P P I+W V ++ +L
Sbjct: 1442 PSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ---VL 1498
Query: 2486 HDNGTLVIKEATAYDRGNYICKAQNSVG------HTLITVPVMI-------VAYPPRITN 2532
+ L I+ D G Y+C A N G + LI VP M A+
Sbjct: 1499 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 1558
Query: 2533 RPPRSIVTRTGAAFQ-----LHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQ 2587
R VT + L+C +P P++TW D L + G E LQ
Sbjct: 1559 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL--------SAGDEVSVLQ 1610
Query: 2588 GTLVIQNP--QTSDSGIYKCTAKNPLGSDY 2615
G V+Q P + ++G Y C A N +G D+
Sbjct: 1611 GGRVLQIPLVRAENAGRYSCKASNEVGEDW 1640
Score = 245 bits (625), Expect = 5e-64
Identities = 218/795 (27%), Positives = 330/795 (41%), Gaps = 78/795 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
P I G A + N A LPC+A G P P + W + LD ++ R ++LP G+
Sbjct: 2482 PTIRSGPPA-VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD----PRSPRFEILPEGS 2536
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L IQ V QD G YLC ASN G+D L V+ P +T H+ + L C
Sbjct: 2537 LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPAL--LPC 2594
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG 1827
A G P P V W Q + QG+ + + + L+L D ++CV SN G
Sbjct: 2595 EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS--NALLLTAPGPQDSAQFECVVSNEVG 2652
Query: 1828 QDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPL 1887
+ L ++ V PP I + + V T + L C + G P P+V W + L
Sbjct: 2653 EAHRLYQVTV-HVPPTIADDQTDFTV-TMMAPVVLTCHSTGIPAPTVSWSKAGAQ----L 2706
Query: 1888 QFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAAS 1947
S + +G L I G Y C A +S G + V LT++ + +
Sbjct: 2707 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVV 2766
Query: 1948 QKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007
+ E +++LL C A+G P+P I W+ V G V P G L I +
Sbjct: 2767 RAVAE----EEVLLPCEASGIPRPTITWQKEGLNVA-----TGVSTQVLPGGQLRIAHAS 2817
Query: 2008 EKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
+D+G YLC+A+N G + + +++ P + G + CKA GSP
Sbjct: 2818 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPP--VIENGLPDLSTTEGSHAFLPCKARGSPE 2875
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P I+W DG ++ A ++T+ +G L + + G YTC A+N +G+
Sbjct: 2876 PNITWD-KDGQPVSGA---------EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR 2925
Query: 2128 DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSI 2187
+VHLT++ + + ++ ++ GD L C G P P+I W + ND +
Sbjct: 2926 ARRRVHLTILVLP--VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV--NDR---PV 2978
Query: 2188 DRYTFHANGSLTINK--VKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRT 2245
+G T+ + V DSG YVC A N G + + V P L ++
Sbjct: 2979 TEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLV 3038
Query: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVH-KNGTLEIRNVR 2304
+++ DC G P P++ WI P GS + +NG+L I
Sbjct: 3039 EPVGGSIQ-----LDCVVRGDPVPDIHWIKDG-----LPLRGSHLRHQLQNGSLTIHRTE 3088
Query: 2305 LSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGN 2364
D+ + C+A NE G + VV +L + P F+ + V G AL C G
Sbjct: 3089 RDDAGRYQCLAENEMGVAKKVV---ILVLQSAPVFQVEPQDMTVRS-GDDVALRCQATGE 3144
Query: 2365 PPPEIIWILPNGTRFSNGPQSYQYLIAS-------NGSFIISKTTREDAGKYRCAARNKV 2417
P P I W+ Q+ Q L AS +GS + DAG Y C A N +
Sbjct: 3145 PTPTIEWL-----------QAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLL 3193
Query: 2418 GYIEKLVILEIGQKP 2432
G L + +P
Sbjct: 3194 GSATARAFLVVRGEP 3208
Score = 235 bits (599), Expect = 5e-61
Identities = 253/1027 (24%), Positives = 407/1027 (39%), Gaps = 123/1027 (11%)
Query: 1653 GKAASFTIPANSDAFLPCEAVGNPLPTIHWTR------VPSG------------------ 1688
G+ A+ + A L C+A G P+P I W + VP G
Sbjct: 101 GRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 160
Query: 1689 LDLSKRKQNSRVQVLPNGTLSIQRV-EIQDRGQYLCSASNL--FGTDHLHVTLSVVSYPP 1745
LD + R+Q +G Q Q + + + F T H + PP
Sbjct: 161 LDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPA----PP 216
Query: 1746 RILER-RTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGT 1804
+L +E+ +G+ VEL+C G P+P V W Q V+ G V DG
Sbjct: 217 SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP----GGPHLQVQEDGQ 272
Query: 1805 LV-LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLP 1863
++ + + D G Y+CVA +P GQ + +++V A P + + ++L
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLL 332
Query: 1864 CTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT-LYIRNLASSDRGTYECIATSS 1922
C A+G P P++ W DG L T++K+ G L + SSD G Y C A+++
Sbjct: 333 CEARGVPTPNITW-FKDGA----LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNA 387
Query: 1923 TGSERRVVMLTMEERVTSPRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSK 1980
G+ + L + P IE A + V G + L C A G P P + W
Sbjct: 388 VGAAEKATRLDV---YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL 444
Query: 1981 AVVDQQHRVGSWIHVYPNGSLF-IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAK 2039
V + + +GS+ + S E SG+Y CVA + G+ ++ V +++ P
Sbjct: 445 PVAESNES-----RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQL 499
Query: 2040 IDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLF 2099
+ + + + G+ ++ C+ASGSPVP I W L +G + T
Sbjct: 500 LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW-LQNGRPAEELAGVQVASQGT------ 552
Query: 2100 NNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV-------ITAAP--RIRQSNKTN 2150
TL+ + V + G + C A N G +V ++V + P + + +
Sbjct: 553 ---TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 609
Query: 2151 KRIKAGDTAVLDCEVTGDPKPKI---------FWLLPSNDMISFSIDRYTFHANGSLTIN 2201
A + PKP + W P+ +++S+ L I
Sbjct: 610 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP-------PPLQIE 662
Query: 2202 KVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDC 2261
KV L D G Y C A N +G+ + L V+ PP I N+ V++ +V +C
Sbjct: 663 KVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVT-----LEC 716
Query: 2262 RAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG-TLEIRNVRLSDSADFICVARNEGG 2320
A G P P+V W + + G +TV +G L I +LSD+ + CVA N G
Sbjct: 717 LASGVPPPDVSWFKGHQ--PVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 772
Query: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS 2380
+ L L V P P + + L C+ G P P ++W L +G S
Sbjct: 773 STELRYGLRVNV---PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNPVS 828
Query: 2381 NGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPG 2440
+ ++ D+G+Y C A + VG + V+L++ P IL
Sbjct: 829 PAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG-EEL 887
Query: 2441 TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD 2500
V ++ ES++L C S +P P + W + RP G ++ D L + A +D
Sbjct: 888 NVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRP---GVHLSADKALLQVDRADVWD 944
Query: 2501 RGNYICKAQNSVG----HTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVP 2556
G+Y C+A N G H + V V P R ++ R G L C GVP
Sbjct: 945 AGHYTCEALNQAGRSEKHYNLNVWV-----APVFPLRESHTLTVREGHPTSLSCECRGVP 999
Query: 2557 KPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLV-IQNPQTSDSGIYKCTAKNPLGSDY 2615
P+I+W L + G + + G L+ + Q + G Y C N +G+
Sbjct: 1000 FPKISWRKDGQPLPGEGA-----GLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSS 1054
Query: 2616 AATYIQV 2622
++V
Sbjct: 1055 QDLQLEV 1061
Score = 231 bits (589), Expect = 7e-60
Identities = 249/1005 (24%), Positives = 397/1005 (39%), Gaps = 96/1005 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG- 1706
PRI + + N+ L C A G P PT+ W + G +S +QV P G
Sbjct: 786 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DGNPVSP-AGTPGLQVFPGGR 842
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELK 1766
L++ D G+Y C A + G D V L V PP IL ++V + +V L+
Sbjct: 843 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQ-VHMPPSILGEEL-NVSVVANESVALE 900
Query: 1767 CRAEGRPSPTVTWILANQTVVSESS--QGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
C++ P P ++W + + + +A++ VD ++D G Y C A N
Sbjct: 901 CQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVD------RADVWDAGHYTCEALN 954
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G+ + V AP L + + V G L C +G P P + W DG
Sbjct: 955 QAGRSEKHYNLNVWVAPVFPLRESHTLTVRE-GHPTSLSCECRGVPFPKISW-RKDG--- 1009
Query: 1885 KPLQFTNSKLFLFS--NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
+PL + L S LY+ + GTY C ++ G+ + + L + P+
Sbjct: 1010 QPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH---VPPQ 1066
Query: 1943 IEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS 2000
I + T+V+ L C+ATG+P P + W + V + +G + S
Sbjct: 1067 IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE---LGLQLQ-NQGQS 1122
Query: 2001 LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK--QVLHGKDFQV 2058
L + +G Y CVA N G +S+ + P I LH +
Sbjct: 1123 LHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALH-SPLTL 1181
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
C+A G P P I W + G T Y L L + + G Y+
Sbjct: 1182 LCEAMGIPPPAIRWF--------RGEEPVSPGEDT--YLLAGGWMLKMTQTQEQDSGLYS 1231
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A N G+ + V+ + + ++ G TA L C VTG P+PK+ W
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1291
Query: 2179 SNDMISFSIDRYTFHANG-SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
+ D + +G L + + L +G Y C+A N G+ TK ++L V+ P ++
Sbjct: 1292 GRPLARG--DAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 1349
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
G + + T ++ C A PSP + W M D AP+ SR GT
Sbjct: 1350 GGAEDSADE-EVTVTVNNPISLICEALAFPSPNITW-MKDG----APFEASRNIQLLPGT 1403
Query: 2298 --LEIRNVRLSDSADFICVARNEGGESVLVVQLEVL---EMLRRPTFRNPFNEKIVAQLG 2352
L+I N + D+ + CV NE GE+V +EVL + + +++ ++
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463
Query: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
+ L C PPP I W +G + P S ++ I T D+G+Y C
Sbjct: 1464 STLTLECESWAVPPPTIRW-YKDGQPVT--PSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1520
Query: 2413 ARNKVGYIEKLVILEIGQKPV------------ILTYAPGTVKGIS-------GESLSLH 2453
A N G ++ + I P+ IL+ G++ L+
Sbjct: 1521 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1580
Query: 2454 CVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRGNYICKAQNS 2511
C ++ IP P++ W Y D+P G +L L I A + G Y CKA N
Sbjct: 1581 CDTNAIPPPDLTW-----YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE 1635
Query: 2512 VGHTLITVPVMIVAYPPRI---TNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHS 2568
VG + ++++ PP I T + + L C ALG P P I+W + +
Sbjct: 1636 VGEDWLHYELLVLT-PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGL 1693
Query: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
S + + + Q+ L + + +D+ Y C A+N GS
Sbjct: 1694 PFSPSPRLQVLEDGQV-----LQVSTAEVADAASYMCVAENQAGS 1733
Score = 196 bits (498), Expect = 3e-49
Identities = 219/893 (24%), Positives = 334/893 (37%), Gaps = 77/893 (8%)
Query: 1767 CRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPG 1826
C G P P VTW + SE G V +G+L L ++S D G Y+C A+N
Sbjct: 24 CGTHGTPKPQVTW---RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEV 80
Query: 1827 GQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKP 1886
G S K+ V P + + R+ + G G+SL L C A G P P + W+ P
Sbjct: 81 GSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP 140
Query: 1887 LQF-----------TNSKLFLFSNGTLYIRNL--ASSDRGTYECIATSSTGSERRVVMLT 1933
L + L +L+ + S R + ++ T + +
Sbjct: 141 LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAG 200
Query: 1934 MEERVT--------SPRIEAASQKRTEVNF-GDKLLLNCSATGEPKPQIMWRLPSKAVVD 1984
E+ T P + A + + G + L C +G P PQ+ W + V+
Sbjct: 201 FEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP 260
Query: 1985 QQHRVGSWIHVYPNGS-LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHK 2043
G + V +G L I D G Y CVA + G + + P
Sbjct: 261 G----GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSN 316
Query: 2044 QYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGT 2103
+ V+ Q+ C+A G P P I+W DG ++ + T+
Sbjct: 317 ETGEVAVMEDHLVQLLCEARGVPTPNITW-FKDGALLPTS---------TKVVYTRGGRQ 366
Query: 2104 LYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIK--AGDTAVL 2161
L + ++ G YTC A N +G E L V P I + +K AG L
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVAL 425
Query: 2162 DCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSG 2220
+C G P P + W + + R +GS L + SG Y CVA +P+G
Sbjct: 426 ECVARGHPSPTLSWHHEGLPVAESNESR--LETDGSVLRLESPGEASSGLYSCVASSPAG 483
Query: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
+ Y ++V P L+ + + T + C+A G+P P + W+
Sbjct: 484 EAVLQYSVEVQVPPQLL----VAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR-- 537
Query: 2281 LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
A + TL I +V L S F C A NE G + V++ V
Sbjct: 538 -PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLE 596
Query: 2341 NPFNEKIVAQLGKST-------ALNCSVDGNPPPEII--WILPNGTRFSNGPQSYQYLIA 2391
P + S+ ++ +P P ++ W P P +
Sbjct: 597 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS--LWGEPTGIPVAYS 654
Query: 2392 SNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKG--ISGES 2449
I K D G Y CAA N G ++ V L++ P I PG V + S
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNI---EPGPVNKAVLENAS 711
Query: 2450 LSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQ 2509
++L C++ G+P P++ W V G + D L I++A D G+Y C A
Sbjct: 712 VTLECLASGVPPPDVSWFKGHQPV---SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 768
Query: 2510 NSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSL 2569
N G T + + V PPRIT P +L C A G P P + W + D +
Sbjct: 769 NVAGSTELRYGLR-VNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNP 826
Query: 2570 LSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+S A T G + L + + + SDSG Y C A + +G D +QV
Sbjct: 827 VSPAG---TPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV 876
Score = 188 bits (477), Expect = 7e-47
Identities = 251/994 (25%), Positives = 364/994 (36%), Gaps = 111/994 (11%)
Query: 1670 CEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLF 1729
C G P P + W + PS L + V VL G+L + V D G Y C A+N
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPG---VAVLEEGSLFLASVSPADSGDYECQATNEV 80
Query: 1730 GTDHLHVTLSVVSYPPRILE-RRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV-- 1786
G+ L VV PP I E R ++ +G ++ L+C A G P P + W+ Q V
Sbjct: 81 GSTSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 139
Query: 1787 -VSESSQGSRQAVVTVDGTLVL-HNLSIYDRGFYKCVASNPGGQ--DSLLVKIQVIA--- 1839
+ + G V G +L S++ + G Q S K A
Sbjct: 140 PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLA 199
Query: 1840 --------------APPVIL-EQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
APP +L Q ++G G ++L C G P P V W +
Sbjct: 200 GFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWT----KDR 255
Query: 1885 KPLQFTNSKLFLFSNG-TLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRI 1943
+P+ L + +G L I D G Y+C+A S G + R L RV +P
Sbjct: 256 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL----RVHAPPT 311
Query: 1944 EAASQKRTEVNFGDKLL--LNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG-- 1999
S + EV + L L C A G P P I W A++ +V VY G
Sbjct: 312 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW-FKDGALLPTSTKV-----VYTRGGR 365
Query: 2000 SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA--KIDHKQYFRKQVLHGKDFQ 2057
L +G D+GVY C A N +G + + + P + Y K V G+
Sbjct: 366 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVA 424
Query: 2058 VDCKASGSPVPEISW---SLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
++C A G P P +SW LP + ++ D S L G A
Sbjct: 425 LECVARGHPSPTLSWHHEGLPVAESNESRLETDGS-------------VLRLESPGEASS 471
Query: 2115 GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIF 2174
G Y+C A + G+ ++ + V + G L C+ +G P P I
Sbjct: 472 GLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 531
Query: 2175 WL---LPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV- 2230
WL P+ ++ + +L I+ V+L SG + C A N +G ++ V
Sbjct: 532 WLQNGRPAEELAGVQV----ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH 587
Query: 2231 ------VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAP 2284
V + P+ + A H A P W P +++
Sbjct: 588 GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLW--GE 645
Query: 2285 YYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR-NPF 2343
G + L+I V L D + C A N GES V L+VL P P
Sbjct: 646 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV---PPNIEPGPV 702
Query: 2344 NEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI--ISKT 2401
N+ ++ S L C G PPP++ W + S+ + S + I +
Sbjct: 703 NKAVLE--NASVTLECLASGVPPPDVSWF-----KGHQPVSSWMGVTVSVDGRVLRIEQA 755
Query: 2402 TREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL--TYAPGTVKGISGESLSLHCVSDGI 2459
DAG YRC A N G E L + P I PG V + + L C + G
Sbjct: 756 QLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPV--LVNTPVRLTCNATGA 813
Query: 2460 PKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITV 2519
P P + W + G V G + L + A A D G Y C A ++VG V
Sbjct: 814 PSPTLMW-LKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 872
Query: 2520 PVMIVAYPPRITNRPPR-SIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERT 2578
V+ V PP I S+V A L C + +P P ++W L E
Sbjct: 873 -VLQVHMPPSILGEELNVSVVANESVA--LECQSHAMPPPVLSWWKDGRPL------EPR 923
Query: 2579 HGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
G + L + D+G Y C A N G
Sbjct: 924 PGVHLSADKALLQVDRADVWDAGHYTCEALNQAG 957
Score = 164 bits (416), Expect = 8e-40
Identities = 117/400 (29%), Positives = 187/400 (46%), Gaps = 33/400 (8%)
Query: 1641 SRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRV 1700
+R + + P ++ + S AFLPC+A G+P P I W + G +S + +
Sbjct: 2839 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTI 2896
Query: 1701 QVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSG 1760
Q P+G L ++ +E QD G Y C+A N G V L+++ P + + ++ G
Sbjct: 2897 Q--PSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP--VFTTLPGDRSLRLG 2952
Query: 1761 STVELKCRAEGRPSPTVTWILANQTV---VSESSQGSRQAVVTVDGTLVLHNLSIYDRGF 1817
+ L+C A G P+P + W + ++ V VSE GS TL +S D G
Sbjct: 2953 DRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGS---------TLQRAAVSREDSGT 3003
Query: 1818 YKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWV 1877
Y C A N G+ + + V A PV+ + +V G S++L C +G P P ++W+
Sbjct: 3004 YVCWAENRVGRTQAVSFVHVKEA-PVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWI 3062
Query: 1878 LSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEER 1937
DG ++ + NG+L I D G Y+C+A + G ++VV+L ++
Sbjct: 3063 -KDGLPLRGSHLRHQ----LQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ-- 3115
Query: 1938 VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
++P + Q T V GD + L C ATGEP P I W Q R + P
Sbjct: 3116 -SAPVFQVEPQDMT-VRSGDDVALRCQATGEPTPTIEW-----LQAGQPLRASRRLRTLP 3168
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP 2037
+GSL++ +V D+G Y CVA N +G + +R +P
Sbjct: 3169 DGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 73.6 bits (179), Expect = 2e-12
Identities = 62/231 (26%), Positives = 103/231 (44%), Gaps = 21/231 (9%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGV 548
VGG++ L+C +GDP P + W + DG +R ++ ++G L + + D G
Sbjct: 3041 VGGSIQLDCVVRGDPVPDIHW-IKDGLPLRGSHLRHQ-----LQNGSLTIHRTERDDAGR 3094
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
Y C++ N + + + +V +Q TV G+ + L C +TG P +I W+
Sbjct: 3095 YQCLAEN--EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL 3152
Query: 609 IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQR 668
G + ++SR + L +G+L + V D G Y CVA N G +
Sbjct: 3153 QAGQPL--RASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG----------SATARA 3200
Query: 669 PLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRH 719
L GE +GS + + ++ A L TS + EA G + +S RH
Sbjct: 3201 FLVVRGEPQGS-WGSMTGVINGRKFGVATLNTSVMQEAHSGVSSIHSSIRH 3250
Score = 71.2 bits (173), Expect = 1e-11
Identities = 61/192 (31%), Positives = 87/192 (45%), Gaps = 11/192 (5%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKV---RAPYVSEDGRILIDKS 533
R + EH VL G V L+C G P P V W L DGS + P++ R +D
Sbjct: 2028 RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSPLGQDMGPHL----RFYLD-G 2081
Query: 534 GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVF-IGETLD 592
G L L+ + D G Y C++ N D + + V+ P +G V GE +
Sbjct: 2082 GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVT 2141
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ C G P +SW+ G L S R + TLRI +V D G + CVAA+P+G
Sbjct: 2142 MVCPVRGSPPIHVSWLKDG-LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2200
Query: 653 VDFLIFQVSVKM 664
V F + V++
Sbjct: 2201 VADRNFTLQVQV 2212
Score = 67.0 bits (162), Expect = 2e-10
Identities = 53/174 (30%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
+ TV + V L C G P P V W SK A + + SG LE+ A
Sbjct: 2674 DFTVTMMAPVVLTCHSTGIPAPTVSW-----SKAGAQLGARGSGYRVSPSGALEIGQALP 2728
Query: 544 FDTGVYHCISSN-----YDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHST 598
G Y C + N + + VV+PL + E + LPC ++
Sbjct: 2729 IHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVR-------AVAEEEVLLPCEAS 2781
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
GIP +I+W G NV S +VL G LRI +P+D G Y C+A N +G
Sbjct: 2782 GIPRPTITWQKEGLNVATGVST--QVLPGGQLRIAHASPEDAGNYLCIAKNSAG 2833
Score = 66.2 bits (160), Expect = 4e-10
Identities = 56/189 (29%), Positives = 84/189 (44%), Gaps = 17/189 (8%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E TV V + L C P+P++ W+ K AP+ + L+ + L++ A
Sbjct: 1359 EVTVTVNNPISLICEALAFPSPNITWM-----KDGAPFEASRNIQLLPGTHGLQILNAQK 1413
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLV----EAYQENGIHHT-VFIGETLDLPCHST 598
D G Y C+ +N + Y + V+ P + E G+ + TL L C S
Sbjct: 1414 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW 1473
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP---KDQGYYRCVAANPSGVDF 655
+P +I W G V SSR +VL G R+LQ+ P D G Y CVA N +G D
Sbjct: 1474 AVPPPTIRWYKDGQPVT-PSSR-LQVLGEG--RLLQIQPTQVSDSGRYLCVATNVAGEDD 1529
Query: 656 LIFQVSVKM 664
F V +++
Sbjct: 1530 QDFNVLIQV 1538
Score = 65.1 bits (157), Expect = 9e-10
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 9/191 (4%)
Query: 479 NNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LE 537
+N E V+ V L C +G PTP++ W DG+ + +++ + G+ L+
Sbjct: 315 SNETGEVAVMEDHLVQLLCEARGVPTPNITWF-KDGA-----LLPTSTKVVYTRGGRQLQ 368
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCH 596
L A S D GVY C +SN A R+ V V P +E G + L C
Sbjct: 369 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECV 428
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFL 656
+ G P ++SW G V +S+ + + LR+ G Y CVA++P+G L
Sbjct: 429 ARGHPSPTLSWHHEGLPVA-ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVL 487
Query: 657 IFQVSVKMKGQ 667
+ V V++ Q
Sbjct: 488 QYSVEVQVPPQ 498
Score = 64.7 bits (156), Expect = 1e-09
Identities = 47/168 (27%), Positives = 80/168 (47%), Gaps = 10/168 (5%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSFDT 546
L G + L C + +P P + W DG ++ ED + G+ L+LQ + D+
Sbjct: 2403 LAPGQLVLECSVEAEPAPKITWH-RDGIVLQ-----EDAHTQFPERGRFLQLQALSTADS 2456
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C + N + + +R+ + V + V + +T LPC + G+P +S
Sbjct: 2457 GDYSCTARNAAGSTSVAFRVEI--HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVS 2514
Query: 607 WVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
W + +S R + +L G+LRI V +D G+Y C+A+N +G D
Sbjct: 2515 WRKDRVPLDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2561
Score = 64.3 bits (155), Expect = 2e-09
Identities = 50/172 (29%), Positives = 71/172 (41%), Gaps = 13/172 (7%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADG--SKVRAPYVSEDGRILIDKSGKLELQMADSF 544
VL +V L C G P P V W S VS DGR+L ++ A
Sbjct: 706 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVL-------RIEQAQLS 758
Query: 545 DTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
D G Y C++SN + L Y + V V P + + V + + L C++TG P
Sbjct: 759 DAGSYRCVASNVAGSTELRYGLRVNVPPRITL--PPSLPGPVLVNTPVRLTCNATGAPSP 816
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVD 654
++ W+ GN V + +V G L + D G Y CVA + G D
Sbjct: 817 TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 868
Score = 62.4 bits (150), Expect = 6e-09
Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 8/176 (4%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
+ G V L C +G P+P + W +G V S + R+ D S L L+ +G
Sbjct: 418 VAGRPVALECVARGHPSPTLSWH-HEGLPVAE---SNESRLETDGS-VLRLESPGEASSG 472
Query: 548 VYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
+Y C++S+ +L Y + V P E T +G+ L+LPC ++G P +I W
Sbjct: 473 LYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 532
Query: 608 VIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+ G + +V + G TL I V G + C A N +G +VSV
Sbjct: 533 LQNGRPA--EELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 586
Score = 61.6 bits (148), Expect = 1e-08
Identities = 49/176 (27%), Positives = 80/176 (45%), Gaps = 16/176 (9%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G V + CP +G P HV WL K P +L L + D G++
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWL-----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIF 2191
Query: 550 HCISSNYDDADILTYRITV-VEPLVEAYQ-ENGIHHTVFIGETLDLPCHSTGIPDASISW 607
C++++ + + V V P++E + +N + V G ++LPC + G+P +SW
Sbjct: 2192 TCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDV--VVVRGSLVELPCEARGVPLPLVSW 2249
Query: 608 VIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+ G +L QS L G +L++ V D G Y CVA + +G FQ++V
Sbjct: 2250 MKDGEPLLSQS------LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2299
Score = 61.6 bits (148), Expect = 1e-08
Identities = 60/194 (30%), Positives = 81/194 (41%), Gaps = 15/194 (7%)
Query: 476 SRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK 535
S N T HT + L C G P P V W DG K+ + + G + S
Sbjct: 2578 SPSNLTLTAHTPAL-----LPCEASGSPKPLVVWW-KDGQKL--DFRLQQGAYRLLPSNA 2629
Query: 536 LELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC 595
L L D+ + C+ SN Y++TV P A + TV + + L C
Sbjct: 2630 LLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDF--TVTMMAPVVLTC 2687
Query: 596 HSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD- 654
HSTGIP ++SW G + + S +V +G L I Q P G Y C A N +GV
Sbjct: 2688 HSTGIPAPTVSWSKAGAQLGARGS-GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2746
Query: 655 ---FLIFQVSVKMK 665
FL Q S +K
Sbjct: 2747 KHVFLTVQASPVVK 2760
Score = 61.2 bits (147), Expect = 1e-08
Identities = 48/177 (27%), Positives = 75/177 (42%), Gaps = 8/177 (4%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V T L C G P P V W K R P R I G L +Q + D
Sbjct: 2493 VSVNQTALLPCQADGVPAPLVSW-----RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDA 2547
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C++SN +D + V+EP A + + T+ LPC ++G P +
Sbjct: 2548 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL--TLTAHTPALLPCEASGSPKPLVV 2605
Query: 607 WVIPGNNVLYQSSRDK-KVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
W G + ++ + ++L + L + P+D + CV +N G ++QV+V
Sbjct: 2606 WWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTV 2662
Score = 60.5 bits (145), Expect = 2e-08
Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 21/179 (11%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V+ G V L C +G P P V W+ DG P +S+ +++ L+L+ + D+
Sbjct: 2227 VVRGSLVELPCEARGVPLPLVSWM-KDGE----PLLSQS----LEQGPSLQLEAVGAGDS 2277
Query: 547 GVYHCISSNYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C++ + +++TV+EP + ++ Q + T G ++L C + G P +
Sbjct: 2278 GTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTP--GAPMELLCDAQGTPQPN 2335
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
I+W G + + N+ R+L+V +D G Y C+A +P+G F+V V+
Sbjct: 2336 ITWHKDGQALTRLEN------NSRATRVLRV--RDAGLYTCLAESPAGAIEKSFRVRVQ 2386
Score = 59.3 bits (142), Expect = 5e-08
Identities = 48/183 (26%), Positives = 77/183 (42%), Gaps = 15/183 (8%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAP--YVSEDGRILIDKSGKLELQMA 541
E TV TV L CP G+P P + WL +P V EDG++ L++ A
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQV-------LQVSTA 1715
Query: 542 DSFDTGVYHCISSNYDDA--DILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
+ D Y C++ N + + T R+ V P + + T + ++ LPC
Sbjct: 1716 EVADAASYMCVAENQAGSAEKLFTLRVQ-VPPRIAGLDLEQV--TAILNSSVSLPCDVHA 1772
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQ 659
P+ ++W + L + TL++ + D G Y C A N +G D + Q
Sbjct: 1773 HPNPEVTW-YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1831
Query: 660 VSV 662
+SV
Sbjct: 1832 LSV 1834
Score = 57.0 bits (136), Expect = 2e-07
Identities = 47/164 (28%), Positives = 69/164 (42%), Gaps = 9/164 (5%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG L+C P P V W DG P V + +LE+Q A D
Sbjct: 1853 VRVGDKAVLSCETDALPEPTVTWY-KDGQ----PLVLAQRTQALRGGQRLEIQEAQVSDK 1907
Query: 547 GVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G+Y C SN + T+ +TV V P E + + G L L C +G+P ++
Sbjct: 1908 GLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA--GSPLVLTCDVSGVPAPTV 1965
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
+W + + S+ V G L++ ++ P G Y CVA N
Sbjct: 1966 TW-LKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 2008
Score = 56.6 bits (135), Expect = 3e-07
Identities = 51/179 (28%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
+V+ G L C G P P V W DG V A E G L ++ L ++ A +
Sbjct: 1078 SVVQDGVATLECNATGKPPPTVTW-ERDGQPVGA----ELGLQLQNQGQSLHVERAQAAH 1132
Query: 546 TGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
TG Y C++ N + ++V V P + + + T + L L C + GIP +
Sbjct: 1133 TGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPA 1192
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
I W V D +L G L++ Q +D G Y C+A+N +G F V V
Sbjct: 1193 IRWFRGEEPV--SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1249
Score = 56.2 bits (134), Expect = 4e-07
Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 8/178 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T + + L C G P P + W + P + L+ L++ D
Sbjct: 1172 TAALHSPLTLLCEAMGIPPPAIRWFRGE-----EPVSPGEDTYLLAGGWMLKMTQTQEQD 1226
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
+G+Y C++SN + + V+ P ++ V G+T L C+ TG P +
Sbjct: 1227 SGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 1286
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTL-RILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+W G + + + +G L ++LQ G+Y C+AAN G FQ+SV
Sbjct: 1287 TWFKDGRPLARGDAHH--ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1342
Score = 53.5 bits (127), Expect = 3e-06
Identities = 41/181 (22%), Positives = 78/181 (43%), Gaps = 8/181 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T ++ +V L C P P V W +A + E+ L+ + L+L A D
Sbjct: 1757 TAILNSSVSLPCDVHAHPNPEVTWY----KDSQALSLGEEV-FLLPGTHTLQLGRARLSD 1811
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI--GETLDLPCHSTGIPDA 603
+G+Y C + N D +++V+ P G V + G+ L C + +P+
Sbjct: 1812 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP 1871
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
+++W G ++ + R + + L I + D+G Y C +N +G F ++V+
Sbjct: 1872 TVTWYKDGQPLVL-AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1930
Query: 664 M 664
+
Sbjct: 1931 V 1931
Score = 53.5 bits (127), Expect = 3e-06
Identities = 46/171 (26%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
+ ++ +G + L C +G PTP + W + D VSE D L+
Sbjct: 2946 DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQ-----DGGSTLQRAAVSR 2998
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVF-IGETLDLPCHSTGIPD 602
D+G Y C + N + V E V Q + V +G ++ L C G P
Sbjct: 2999 EDSGTYVCWAENRVGRTQAVSFVHVKEAPV--LQGEAFSYLVEPVGGSIQLDCVVRGDPV 3056
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
I W+ G + + S + L NG+L I + D G Y+C+A N GV
Sbjct: 3057 PDIHWIKDG--LPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGV 3105
Score = 52.8 bits (125), Expect = 5e-06
Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 10/174 (5%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G L C +G P P++ W K P +G+ I SG+L ++ + D G Y
Sbjct: 2861 GSHAFLPCKARGSPEPNITW-----DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTY 2915
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C + N +T++ ++ + ++ +G+ L L C + G P I W +
Sbjct: 2916 TCTAENAVGRARRRVHLTIL--VLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2973
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
V S TL+ V+ +D G Y C A N G + V VK
Sbjct: 2974 NDRPVTEGVSEQD---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 3024
Score = 52.0 bits (123), Expect = 8e-06
Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 10/173 (5%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L C P P + W D P + D ++ L++ + + + G Y C +S
Sbjct: 1579 LYCDTNAIPPPDLTWYRED-----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1633
Query: 555 NYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGN 612
N D L Y + V+ P ++ +E TV T+ L C + G P +ISW+ N
Sbjct: 1634 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL--QN 1691
Query: 613 NVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKM 664
+ + S +VL +G L++ D Y CVA N +G +F + V++
Sbjct: 1692 GLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQV 1744
Score = 50.8 bits (120), Expect = 2e-05
Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 2442 VKGISGESLSLH-----CVSDGIPKPNIKWTM-PSGYVVDRPQINGKYILHDNGTLVIKE 2495
+KG+ +L++ C + G PKP + W PS + G +L + G+L +
Sbjct: 7 IKGLGDVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQP--GVAVLEE-GSLFLAS 63
Query: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVT-RTGAAFQLHCVALG 2554
+ D G+Y C+A N VG T ++V PP I ++ V+ G + L C A G
Sbjct: 64 VSPADSGDYECQATNEVGSTSRRAK-LVVYVPPSIREDGRKANVSGMAGQSLTLECDANG 122
Query: 2555 VPKPEITW 2562
P PEI W
Sbjct: 123 FPVPEIVW 130
Score = 50.8 bits (120), Expect = 2e-05
Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 9/167 (5%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSFDT 546
L G V L C G PTP V+W +K R P + + + + G+ L + + D
Sbjct: 230 LAGADVELQCWTSGVPTPQVEW-----TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDE 284
Query: 547 GVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G Y C++ + +++ V P + E G V + L C + G+P +I
Sbjct: 285 GRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETG-EVAVMEDHLVQLLCEARGVPTPNI 343
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+W G +L S++ L++ + D G Y C A+N G
Sbjct: 344 TWFKDG-ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 389
Score = 49.7 bits (117), Expect = 4e-05
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 22/186 (11%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L C G P P + W +G V ++ + G+L + A D G Y CI+
Sbjct: 2776 LPCEASGIPRPTITWQ-KEGLNVATGVSTQ-----VLPGGQLRIAHASPEDAGNYLCIAK 2829
Query: 555 NYDDADILTYRITVVEPLVEAYQENGIHH-TVFIGETLDLPCHSTGIPDASISWVIPGNN 613
N + + R+ V P V ENG+ + G LPC + G P+ +I+W G
Sbjct: 2830 NSAGSAMGKTRLVVQVPPV---IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP 2886
Query: 614 VLYQSSRDKK--VLNNGTLRILQVTPKDQGYYRCVAANPSG-------VDFLIFQVSVKM 664
V S + K + +G L + + +D G Y C A N G + L+ V +
Sbjct: 2887 V---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL 2943
Query: 665 KGQRPL 670
G R L
Sbjct: 2944 PGDRSL 2949
Score = 47.8 bits (112), Expect = 1e-04
Identities = 42/179 (23%), Positives = 73/179 (40%), Gaps = 19/179 (10%)
Query: 498 PGQGDPTPHVDWLLADGSKVRAPYVS---EDGRILIDKSG---------KLELQMADSFD 545
P DP H W G+ + P V G + + +G L+++ D D
Sbjct: 613 PAACDPPVHRGW----GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 668
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G+Y C ++N + V+ P + ++ V ++ L C ++G+P +
Sbjct: 669 EGIYTCAATNLAGESKREVALKVLVP--PNIEPGPVNKAVLENASVTLECLASGVPPPDV 726
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKM 664
SW G+ + ++ LRI Q D G YRCVA+N +G L + + V +
Sbjct: 727 SW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 784
Score = 46.6 bits (109), Expect = 3e-04
Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 9/188 (4%)
Query: 482 KLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMA 541
+L +V+ +V L C P P + W K P G L L++ A
Sbjct: 886 ELNVSVVANESVALECQSHAMPPPVLSWW-----KDGRPLEPRPGVHLSADKALLQVDRA 940
Query: 542 DSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
D +D G Y C + N Y + V V P+ + + + TV G L C G+
Sbjct: 941 DVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTL--TVREGHPTSLSCECRGV 998
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRIL-QVTPKDQGYYRCVAANPSGVDFLIFQ 659
P ISW G + + + + V G L L Q +G Y C +N G Q
Sbjct: 999 PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 1058
Query: 660 VSVKMKGQ 667
+ V + Q
Sbjct: 1059 LEVHVPPQ 1066
Score = 45.8 bits (107), Expect = 6e-04
Identities = 49/185 (26%), Positives = 77/185 (41%), Gaps = 19/185 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDW------LLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
TV G L+C +G P P + W L +G+ ++ +VS GR+L L
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQ--HVSAVGRLLY-------LG 1032
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHST 598
A G Y C SN ++ V V P + +E +V L C++T
Sbjct: 1033 QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT 1092
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLI 657
G P +++W G V + ++ N G +L + + G Y CVA N +G
Sbjct: 1093 GKPPPTVTWERDGQPV--GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK 1150
Query: 658 FQVSV 662
F++SV
Sbjct: 1151 FELSV 1155
Score = 44.3 bits (103), Expect = 0.002
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 6/70 (8%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV G V L C G+PTP ++WL A G +RA S R L D G L L+ ++ D
Sbjct: 3128 TVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRA---SRRLRTLPD--GSLWLENVETGD 3181
Query: 546 TGVYHCISSN 555
G Y C++ N
Sbjct: 3182 AGTYDCVAHN 3191
Score = 43.1 bits (100), Expect = 0.004
Identities = 52/233 (22%), Positives = 88/233 (37%), Gaps = 25/233 (10%)
Query: 435 SLQLNRTAT----TFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVG 490
SLQL T+S + + + +A+ M P + D+ E ++ G
Sbjct: 2266 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIE------DSGQPTELSLTPG 2319
Query: 491 GTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYH 550
+ L C QG P P++ W + R S R+L + D G+Y
Sbjct: 2320 APMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR------------DAGLYT 2367
Query: 551 CISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGE-TLDLPCHSTGIPDASISWVI 609
C++ + A ++R+ V P G V + L L C P I+W
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAP-PNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 2426
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
G VL + + + L++ ++ D G Y C A N +G + F+V +
Sbjct: 2427 DG-IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2478
Score = 42.0 bits (97), Expect = 0.008
Identities = 43/194 (22%), Positives = 76/194 (39%), Gaps = 28/194 (14%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKL-ELQMADSFDTG 547
V T+ L C P P + W DG V + R+ + G+L ++Q D+G
Sbjct: 1462 VNSTLTLECESWAVPPPTIRWY-KDGQPV-----TPSSRLQVLGEGRLLQIQPTQVSDSG 1515
Query: 548 VYHCISSNYDDADILTYRITVVEPLV----------------EAYQENGI--HHTVFIGE 589
Y C+++N D + + + P + E G+ + +
Sbjct: 1516 RYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENN 1575
Query: 590 TLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAA 648
L C + IP ++W + + + VL G L+I V ++ G Y C A+
Sbjct: 1576 PAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1633
Query: 649 NPSGVDFLIFQVSV 662
N G D+L +++ V
Sbjct: 1634 NEVGEDWLHYELLV 1647
Score = 40.8 bits (94), Expect = 0.018
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 11/122 (9%)
Query: 492 TVGLN---CPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGV 548
TVGL C G P P V W S+ P + G ++++ G L L D+G
Sbjct: 16 TVGLEAGGCGTHGTPKPQVTWRKGPSSE---PLHGQPGVAVLEE-GSLFLASVSPADSGD 71
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTV--FIGETLDLPCHSTGIPDASIS 606
Y C ++N + ++ V P + +E+G V G++L L C + G P I
Sbjct: 72 YECQATNEVGSTSRRAKLVVYVP--PSIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 129
Query: 607 WV 608
W+
Sbjct: 130 WL 131
Score = 39.3 bits (90), Expect = 0.052
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 12/81 (14%)
Query: 588 GETLDLPCHSTGIPDASISW------VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQG 641
G ++L C ++G+P + W V+PG L Q D +VL RI D+G
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHL-QVQEDGQVL-----RITGSHVGDEG 285
Query: 642 YYRCVAANPSGVDFLIFQVSV 662
Y+CVA +P+G FQ+ V
Sbjct: 286 RYQCVAFSPAGQQARDFQLRV 306
Score = 34.7 bits (78), Expect = 1.3
Identities = 42/179 (23%), Positives = 64/179 (35%), Gaps = 18/179 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLL--ADGSKVRAPYVSEDGRIL------IDKSGKLE 537
T +VG + L C G P P + WL ++ V+ G L +D SG
Sbjct: 509 TTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFA 568
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH- 596
Q + T S + + + V+E + Y HH+ F D P H
Sbjct: 569 CQATNEAGTAGAEVEVSVHGE-----WAPGVLEVPIGQYHWGXEHHSSF-PAACDPPVHR 622
Query: 597 ---STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ P W PG+ + L+I +V +D+G Y C A N +G
Sbjct: 623 GWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 681
Score = 33.5 bits (75), Expect = 2.8
Identities = 17/58 (29%), Positives = 25/58 (43%)
Query: 595 CHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
C + G P ++W ++ VL G+L + V+P D G Y C A N G
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 299 bits (766), Expect = 2e-80
Identities = 279/994 (28%), Positives = 421/994 (42%), Gaps = 101/994 (10%)
Query: 1648 PRI-VGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR--VPSGLDLSKRKQNSRVQVLP 1704
PRI G A + + L CEA G P P + W + P G D+ + L
Sbjct: 3216 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF----YLD 3271
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHS--GST 1762
G+L ++ + D G Y C A N G D T++V+ PP I + T+ S G
Sbjct: 3272 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL-VPPTIKQGADGSGTLVSRPGEL 3330
Query: 1763 VELKCRAEGRPSPTVTWI-------LANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR 1815
V + C G P V+W+ L+ +T++ S TL + + + D
Sbjct: 3331 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH-----------TLRISKVQLADA 3379
Query: 1816 GFYKCVASNPGGQDSLLVKIQVIAAPPVI--LEQRRQVIVGTWGESLKLPCTAKGTPQPS 1873
G + CVA++P G +QV PPV+ +E + V+V G ++LPC A+G P P
Sbjct: 3380 GIFTCVAASPAGVADRNFTLQV-QVPPVLEPVEFQNDVVV-VRGSLVELPCEARGVPLPL 3437
Query: 1874 VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
V W + DG +PL + L +L + + + D GTY C+A S G RR LT
Sbjct: 3438 VSW-MKDG---EPLLSQS----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 3489
Query: 1934 MEERVTSPRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGS 1991
+ E P IE + Q TE++ G + L C A G P+P I W H+ G
Sbjct: 3490 VME---PPHIEDSGQP-TELSLTPGAPMELLCDAQGTPQPNITW-----------HKDGQ 3534
Query: 1992 WIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVL 2051
+ N S + +D+G+Y C+A + G V ++ P + + L
Sbjct: 3535 ALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 3594
Query: 2052 HGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGV 2111
++C P P+I+W DG + +Q D R L +
Sbjct: 3595 APGQLVLECSVEAEPAPKITWH-RDGIV----LQEDAHTQFPER-----GRFLQLQALST 3644
Query: 2112 AEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKP 2171
A+ GDY+C A+N G + + + T P IR S + TA+L C+ G P P
Sbjct: 3645 ADSGDYSCTARNAAGSTSVAFRVEIHT-VPTIR-SGPPAVNVSVNQTALLPCQADGVPAP 3702
Query: 2172 KIFWLLPSNDMISFS--IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLD 2229
+ W D + R+ GSL I V D+G Y+C+A N +G D + L
Sbjct: 3703 LVSW---RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR 3759
Query: 2230 VVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
V+ +PP I +N T+ H+ C A G+P P V+W D L
Sbjct: 3760 VL-EPPAIAPSPSNLTL-----TAHTPALLPCEASGSPKPLVVW-WKDGQKLDFRLQQGA 3812
Query: 2290 ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVA 2349
+ + L + DSA F CV NE GE+ + Q+ V PT + + V
Sbjct: 3813 YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIADDQTDFTVT 3869
Query: 2350 QLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKY 2409
+ L C G P P + W + G + Y ++ +G+ I + AG+Y
Sbjct: 3870 MMA-PVVLTCHSTGIPAPTVSW---SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 3925
Query: 2410 RCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP 2469
C+ARN G K V L + PV+ P V+ ++ E + L C + GIP+P I W
Sbjct: 3926 TCSARNSAGVAHKHVFLTVQASPVVKP-LPSVVRAVAEEEVLLPCEASGIPRPTITWQKE 3984
Query: 2470 SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
V + G L I A+ D GNY+C A+NS G + ++V PP
Sbjct: 3985 GLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR-LVVQVPPV 4039
Query: 2530 ITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT 2589
I N P T AF L C A G P+P ITW+ D +S A G + G
Sbjct: 4040 IENGLPDLSTTEGSHAF-LPCKARGSPEPNITWD-KDGQPVSGA-----EGKFTIQPSGE 4092
Query: 2590 LVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L+++N + D+G Y CTA+N +G ++ ++
Sbjct: 4093 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL 4126
Score = 298 bits (763), Expect = 5e-80
Identities = 257/994 (25%), Positives = 427/994 (42%), Gaps = 103/994 (10%)
Query: 1644 IFEKPRIV-GGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV 1702
+ E P I G+ ++ + L C+A G P P I W + G L++ + NSR
Sbjct: 3490 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK--DGQALTRLENNSR--- 3544
Query: 1703 LPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
+ + + ++D G Y C A + G + V + P + R + + +
Sbjct: 3545 ------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ 3598
Query: 1763 VELKCRAEGRPSPTVTW----ILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFY 1818
+ L+C E P+P +TW I+ + ++ + R L L LS D G Y
Sbjct: 3599 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGR--------FLQLQALSTADSGDY 3650
Query: 1819 KCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVL 1878
C A N G S+ ++++ P + + + ++ LPC A G P P V W
Sbjct: 3651 SCTARNAAGSTSVAFRVEIHTVPTI--RSGPPAVNVSVNQTALLPCQADGVPAPLVSW-- 3706
Query: 1879 SDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
+ PL + + + G+L I+ + + D G Y C+A++S GS+R+ + RV
Sbjct: 3707 --RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQ----GRDLRV 3760
Query: 1939 TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN 1998
P A S + LL C A+G PKP ++W + + D + + G++ + P+
Sbjct: 3761 LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKL-DFRLQQGAY-RLLPS 3818
Query: 1999 GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQV 2058
+L + + +DS + CV N++G+ L V++ + P D + F ++ +
Sbjct: 3819 NALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMM--APVVL 3876
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
C ++G P P +SWS + G R Y + +G L + G YT
Sbjct: 3877 TCHSTGIPAPTVSWSKAGAQL----------GARGSGYRVSPSGALEIGQALPIHAGRYT 3926
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A+N+ G V LTV A+P ++ + + A + +L CE +G P+P I W
Sbjct: 3927 CSARNSAGVAHKHVFLTV-QASPVVKPLPSVVRAV-AEEEVLLPCEASGIPRPTITWQKE 3984
Query: 2179 SNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI- 2237
++ + + G L I D+G Y+C+A+N +G +L VV PP+I
Sbjct: 3985 GLNVATGVSTQVL--PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL-VVQVPPVIE 4041
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGS--RITVHKN 2295
NGL T S C+A G+P P + W P G+ + T+ +
Sbjct: 4042 NGLPDLSTT------EGSHAFLPCKARGSPEPNITWDKDGQ-----PVSGAEGKFTIQPS 4090
Query: 2296 GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKST 2355
G L ++N+ D+ + C A N G + V L +L + P F ++ + +LG
Sbjct: 4091 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSL-RLGDRL 4146
Query: 2356 ALNCSVDGNPPPEIIWILPN-----GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYR 2410
L C+ G+P P I W + + G +G + Q S RED+G Y
Sbjct: 4147 WLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS----------REDSGTYV 4196
Query: 2411 CAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPS 2470
C A N+VG + + + + + PV+ A + G S+ L CV G P P+I W
Sbjct: 4197 CWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW---- 4252
Query: 2471 GYVVDRPQINGKYILHD--NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPP 2528
+ D + G ++ H NG+L I D G Y C A+N +G V +++ + P
Sbjct: 4253 --IKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP- 4309
Query: 2529 RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQG 2588
+ P+ + R+G L C A G P P I W L R + G
Sbjct: 4310 -VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-------LQAGQPLRASRRLRTLPDG 4361
Query: 2589 TLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+L ++N +T D+G Y C A N LGS A ++ V
Sbjct: 4362 SLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 4395
Score = 288 bits (737), Expect = 5e-77
Identities = 258/976 (26%), Positives = 408/976 (41%), Gaps = 126/976 (12%)
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
N + I R + G Y C+A + GT + V PP+++ +TV G T
Sbjct: 478 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP--APNVTVSPGETAV 535
Query: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
L CR G +TW+ + + + + + ++ A D +L + + D G Y+CVASN
Sbjct: 536 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASN 591
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G V + V AP V + Q + G +K+ C+A G P P + W E
Sbjct: 592 ANGVTRASVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISW----SRES 645
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
+ LQ +S++ + + GTL I+ +A D G Y C AT+ G+++ V L T P
Sbjct: 646 QALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY----TDPPSV 700
Query: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS---- 2000
+A V G++ +L C A+G P P+++W +R G + + P GS
Sbjct: 701 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----------YRGGLEMILAPEGSSSGK 749
Query: 2001 LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDC 2060
L I + E+D+G Y C A N++GD + +++ P + + ++ G+ + C
Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL--GRSALLAC 807
Query: 2061 KASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCY 2120
+A+G P P ++W DG + + A G R+R+ ++G L+F V ++ Y C
Sbjct: 808 RATGRPPPTVTWRRGDGQPLGLRLGAG-RGSRSRQP---DSGVLFFESVAPEDQAPYVCE 863
Query: 2121 AQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEV-TGDPKPKIFWLLPS 2179
A+N GK + + L V AP S+ R+ G L C V G P P+ WL
Sbjct: 864 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 923
Query: 2180 NDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLING 2239
+ S R++ A+GSL +++ +G Y CVA N +G + +L VV PP I+
Sbjct: 924 RPLPPGS--RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHP 980
Query: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLE 2299
T+ + C A G P+P + W N + G V K GTL
Sbjct: 981 TATHHITNEGVPA-----SLPCVASGVPAPTITWTKETNALTSR---GPHYNVSKEGTLL 1032
Query: 2300 IRNVRLSDSADFICVARNEGGESVLVVQLEVLEM-------------------------- 2333
I D+ ++C A N G S ++L V +
Sbjct: 1033 IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVG 1092
Query: 2334 -----------------------LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEII 2370
++ P P + +G++ LNC +GNP P++
Sbjct: 1093 DSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLS 1152
Query: 2371 WILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQ 2430
W GPQ GS + DAG+YRC A N G V L + +
Sbjct: 1153 WSKDGVVLQGRGPQ---------GSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLE 1203
Query: 2431 KPVI-LTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTM-PSGYVVDRPQINGKYILHDN 2488
P G ++ ++GE+ SL C + G PKP + W PS + G +L +
Sbjct: 1204 PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQP--GVAVL-EE 1260
Query: 2489 GTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVT-RTGAAFQ 2547
G+L + + D G+Y C+A N VG T ++V PP I ++ V+ G +
Sbjct: 1261 GSLFLASVSPADSGDYECQATNEVGSTSRRAK-LVVYVPPSIREDGRKANVSGMAGQSLT 1319
Query: 2548 LHCVALGVPKPEITWEMPDHSLLST----------ASKERTHGSEQLHLQGTLVIQNPQT 2597
L C A G P PEI W + D L+ + G L +L Q
Sbjct: 1320 LECDANGFPVPEIVW-LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQE 1378
Query: 2598 SDSGIYKCTAKNPLGS 2613
DSG+Y C A+N G+
Sbjct: 1379 GDSGLYSCRAENQAGT 1394
Score = 278 bits (711), Expect = 5e-74
Identities = 261/962 (27%), Positives = 387/962 (40%), Gaps = 91/962 (9%)
Query: 1670 CEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG---TLSIQRVEIQDRGQYLCSAS 1726
C G+P + W + L LS+R L +G TL I +V++ D G + C A+
Sbjct: 3335 CPVRGSPPIHVSWLKDGLPLPLSQR-------TLLHGSGHTLRISKVQLADAGIFTCVAA 3387
Query: 1727 NLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV 1786
+ G + TL V P ++ V GS VEL C A G P P V+W+ + +
Sbjct: 3388 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 3447
Query: 1787 VSES-SQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVIL 1845
+S+S QG +L L + D G Y CVA + G+ ++ V+ P +
Sbjct: 3448 LSQSLEQGP---------SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED 3498
Query: 1846 EQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIR 1905
+ + T G ++L C A+GTPQP++ W DG + L+ N + R
Sbjct: 3499 SGQPTELSLTPGAPMELLCDAQGTPQPNITWH-KDGQALTRLE----------NNSRATR 3547
Query: 1906 NLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGD-KLLLNCS 1964
L D G Y C+A S G+ + + ++ P I R V +L+L CS
Sbjct: 3548 VLRVRDAGLYTCLAESPAGAIEKSFRVRVQ---APPNIVGPRGPRFVVGLAPGQLVLECS 3604
Query: 1965 ATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIG--SVTEKDSGVYLCVARNKM 2022
EP P+I W + + H +P F+ +++ DSG Y C ARN
Sbjct: 3605 VEAEPAPKITWHRDGIVLQEDAHTQ------FPERGRFLQLQALSTADSGDYSCTARNAA 3658
Query: 2023 GDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINN 2082
G + V + P V + + C+A G P P +SW +
Sbjct: 3659 GSTSVAFRVEIHTVPTIRSGPPAVNVSV--NQTALLPCQADGVPAPLVSWR-------KD 3709
Query: 2083 AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPR 2142
+ D R+ R+ + G+L V + G Y C A N+ G D L V+ P
Sbjct: 3710 RVPLDP---RSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-PA 3765
Query: 2143 IRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDR--YTFHANGSLTI 2200
I S +N + A A+L CE +G PKP + W + F + + Y + +L +
Sbjct: 3766 IAPS-PSNLTLTAHTPALLPCEASGSPKPLVVWW-KDGQKLDFRLQQGAYRLLPSNALLL 3823
Query: 2201 NKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFD 2260
DS ++ CV N G+ ++Y++ V PP I T+ TV V
Sbjct: 3824 TAPGPQDSAQFECVVSNEVGEAHRLYQV-TVHVPPTIADDQTDFTVTMMAPVV-----LT 3877
Query: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG 2320
C + G P+P V W GS V +G LEI + + C ARN G
Sbjct: 3878 CHSTGIPAPTVSW---SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG 3934
Query: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS 2380
V V ++ P + A + L C G P P I W G +
Sbjct: 3935 ----VAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW-QKEGLNVA 3989
Query: 2381 NGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPG 2440
G + + G I+ + EDAG Y C A+N G L + PVI P
Sbjct: 3990 TGVSTQ---VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD 4046
Query: 2441 TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD 2500
+ G L C + G P+PNI W G V + GK+ + +G L++K D
Sbjct: 4047 -LSTTEGSHAFLPCKARGSPEPNITWDK-DGQPVSGAE--GKFTIQPSGELLVKNLEGQD 4102
Query: 2501 RGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEI 2560
G Y C A+N+VG V + I+ P T RS+ R G L C A G P P I
Sbjct: 4103 AGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL--RLGDRLWLRCAARGSPTPRI 4160
Query: 2561 TWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYI 2620
W + D + S E+ GS TL DSG Y C A+N +G A +++
Sbjct: 4161 GWTVNDRPVTEGVS-EQDGGS-------TLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 4212
Query: 2621 QV 2622
V
Sbjct: 4213 HV 4214
Score = 276 bits (706), Expect = 2e-73
Identities = 255/929 (27%), Positives = 395/929 (42%), Gaps = 81/929 (8%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L I++V+++D G Y C+A+NL G V L V+ PP I E V ++V L+C
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNI-EPGPVNKAVLENASVTLEC 1907
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG-TLVLHNLSIYDRGFYKCVASNPG 1826
A G P P V+W +Q V S V+VDG L + + D G Y+CVASN
Sbjct: 1908 LASGVPPPDVSWFKGHQPVSSWMG-----VTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 1962
Query: 1827 GQDSLLVKIQVIAAPPVILEQR--RQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G L ++V P + L V+V T ++L C A G P P++ W L DG V
Sbjct: 1963 GSTELRYGLRVNVPPRITLPPSLPGPVLVNT---PVRLTCNATGAPSPTLMW-LKDGNPV 2018
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
P ++F L + + +SD G Y C+A S+ G +R+ V+L +V P
Sbjct: 2019 SPAGTPGLQVFP-GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL----QVHMPPSI 2073
Query: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF-I 2003
+ V + + L C + P P + W + + + R G +H+ + +L +
Sbjct: 2074 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL---EPRPG--VHLSADKALLQV 2128
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKAS 2063
D+G Y C A N+ G ++++ + P ++ V G + C+
Sbjct: 2129 DRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPV-FPLRESHTLTVREGHPTSLSCECR 2187
Query: 2064 GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQN 2123
G P P+ISW DG + + +G ++ LY + +A+EG YTC N
Sbjct: 2188 GVPFPKISWR-KDG----QPLPGEGAG---LQHVSAVGRLLYLGQAQLAQEGTYTCECSN 2239
Query: 2124 TLGKD----EMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPS 2179
+G +++VH+ A PR T + A L+C TG P P + W
Sbjct: 2240 VVGNSSQDLQLEVHVPPQIAGPR---EPPTQVSVVQDGVATLECNATGKPPPTVTW-ERD 2295
Query: 2180 NDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLING 2239
+ + + SL + + + +G Y CVA N +G + ++L V+ P LI
Sbjct: 2296 GQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD 2355
Query: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG--T 2297
L + TA HS C A G P P + W + P T G
Sbjct: 2356 L---DPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEE-----PVSPGEDTYLLAGGWM 2407
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQL-GKSTA 2356
L++ + DS + C+A NE GE+ +EVL P+ N E+++ L G++
Sbjct: 2408 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV---PPSIENEDLEEVIKVLDGQTAH 2464
Query: 2357 LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI-ISKTTREDAGKYRCAARN 2415
L C+V G+P P++ W +G + G + I+ +G + + + AG Y C A N
Sbjct: 2465 LMCNVTGHPQPKLTW-FKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAAN 2520
Query: 2416 KVGYIEKLVILEIGQKPVILTYAPGT----VKGISGESLSLHCVSDGIPKPNIKWTMPSG 2471
VG K L + P IL A + V +SL C + P PNI W M G
Sbjct: 2521 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MKDG 2579
Query: 2472 YVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRIT 2531
+ + +L L I A D G Y C N +G + V ++ PP I+
Sbjct: 2580 APFEASR--NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPPSIS 2636
Query: 2532 NRPP------RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
P + + T+ + L C + VP P I W D ++ +S+ + G +L
Sbjct: 2637 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-YKDGQPVTPSSRLQVLGEGRL- 2694
Query: 2586 LQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
L IQ Q SDSG Y C A N G D
Sbjct: 2695 ----LQIQPTQVSDSGRYLCVATNVAGED 2719
Score = 269 bits (687), Expect = 3e-71
Identities = 272/1047 (25%), Positives = 401/1047 (38%), Gaps = 148/1047 (14%)
Query: 1659 TIPANSDAFLPCEAVGNPLPTIHWTR---VPSGLDLSKRKQNSRVQVLPNGTLSIQRVEI 1715
T+ A L C A G P PT+ W R P GL L + SR + +G L + V
Sbjct: 796 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFFESVAP 854
Query: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRA-EGRPS 1774
+D+ Y+C A N+FG L V + P + + V G V L C GRP
Sbjct: 855 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914
Query: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVK 1834
P W+ + + GSR ++ DG+L L G Y CVA+N G V+
Sbjct: 915 PERHWLKDGRPL----PPGSRHSI-RADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 969
Query: 1835 IQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+ V+ PP I I G LPC A G P P++ W E L
Sbjct: 970 L-VVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWT----KETNALTSRGPHY 1023
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRI-------EAAS 1947
+ GTL I ++ D G Y C AT++ G + + L++ S + + S
Sbjct: 1024 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGS 1083
Query: 1948 QKRTEVNFGDK------------------------------------------LLLNCSA 1965
+ +V GD L LNC A
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVA 1143
Query: 1966 TGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDD 2025
G P+PQ+ W SK V Q R P GS+ ++ D+G Y C A N G D
Sbjct: 1144 EGNPEPQLSW---SKDGVVLQGRG-------PQGSVHFAAIRTSDAGRYRCEASNSAGVD 1193
Query: 2026 LILMHVSLR-LKPAK--IDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINN 2082
V LR L+P D ++V G++ + C A G+P P+++W
Sbjct: 1194 A--WEVELRVLEPPHWGADETSGLLERVA-GENASLPCPARGTPKPQVTW---------R 1241
Query: 2083 AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPR 2142
+ + H + G+L+ V A+ GDY C A N +G + L V+ P
Sbjct: 1242 KGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKL-VVYVPPS 1300
Query: 2143 IRQSN-KTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSN-------------DMISFSID 2188
IR+ K N AG + L+C+ G P P+I WL + D+ +
Sbjct: 1301 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 2189 RYTFHANG-SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVI 2247
+ G SL +++ DSG Y C A N +G + + L V++ PP + G + V+
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT-PPSVLGAGAAQEVL 1419
Query: 2248 KATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG-TLEIRNVRLS 2306
+ + C G P+P+V W L G + V ++G L I +
Sbjct: 1420 ---GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG---GPHLQVQEDGQVLRITGSHVG 1473
Query: 2307 DSADFICVARNEGGESVLVVQLEVLEMLRRPTF--RNPFNEKIVAQLGKSTALNCSVDGN 2364
D + CVA + G+ QL V PT N E V + L C G
Sbjct: 1474 DEGRYQCVAFSPAGQQARDFQLRVHAP---PTIWGSNETGEVAVME-DHLVQLLCEARGV 1529
Query: 2365 PPPEIIW-----ILPNGTR--FSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKV 2417
P P I W +LP T+ ++ G + Q + + DAG Y C A N V
Sbjct: 1530 PTPNITWFKDGALLPTSTKVVYTRGGRQLQ----------LGRAQSSDAGVYTCKASNAV 1579
Query: 2418 GYIEKLVILEIGQKPVILTYA--PGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD 2475
G EK L++ P I P VK ++G ++L CV+ G P P + W V +
Sbjct: 1580 GAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAE 1639
Query: 2476 RPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPP 2535
N + D L ++ G Y C A + G ++ V + P +
Sbjct: 1640 S---NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGL 1696
Query: 2536 RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNP 2595
+ T G +L C A G P P I W L + E G + TL I +
Sbjct: 1697 GQVTTIVGQPLELPCQASGSPVPTIQW------LQNGRPAEELAGVQVASQGTTLHIDHV 1750
Query: 2596 QTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ SG++ C A N G+ A + V
Sbjct: 1751 ELDHSGLFACQATNEAGTAGAEVEVSV 1777
Score = 268 bits (685), Expect = 5e-71
Identities = 262/1043 (25%), Positives = 417/1043 (39%), Gaps = 137/1043 (13%)
Query: 1645 FEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP 1704
+ P V A + +A L CEA G P P + W R GL++ + S
Sbjct: 694 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGS-----S 746
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
+G L I + +D G Y C A N G + L+ V + P++ E +++TV G +
Sbjct: 747 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA-VGHAPQLTE-LPRDVTVELGRSAL 804
Query: 1765 LKCRAEGRPSPTVTWILANQTVVS---ESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
L CRA GRP PTVTW + + + +GSR G L +++ D+ Y C
Sbjct: 805 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD-SGVLFFESVAPEDQAPYVCE 863
Query: 1822 ASNPGGQDSLLVKIQVIA-APPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLS 1879
A N G+ ++ V APP I V V G+ + LPC G P P +W L
Sbjct: 864 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV-LEGQPVSLPCIVLAGRPLPERHW-LK 921
Query: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
DG + P S+ + ++G+L++ G Y C+AT++ GS+ R V L ++
Sbjct: 922 DGRPLPP----GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ---V 974
Query: 1940 SPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG 1999
PRI + N G L C A+G P P I W + A+ + G +V G
Sbjct: 975 PPRIHPTATHHI-TNEGVPASLPCVASGVPAPTITWTKETNALTSR----GPHYNVSKEG 1029
Query: 2000 SLFIGSVTEKDSGVYLCVARNKMG---------------------DDLILMHVSLRLKPA 2038
+L I + +D+G Y+C A N +G + +L SLRL
Sbjct: 1030 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQV 1089
Query: 2039 KIDHKQYFR------------------------------KQVLHGKDFQVDCKASGSPVP 2068
++ ++ +VL G+ ++C A G+P P
Sbjct: 1090 QVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEP 1149
Query: 2069 EISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKD 2128
++SWS DG ++ G+++F + ++ G Y C A N+ G D
Sbjct: 1150 QLSWS-KDGVVLQGRGP---------------QGSVHFAAIRTSDAGRYRCEASNSAGVD 1193
Query: 2129 EMKVHLTVITAAPRIRQSNKTNKRIK--AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
+V L V+ P +++T+ ++ AG+ A L C G PKP++ W +
Sbjct: 1194 AWEVELRVL--EPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHG 1251
Query: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTV 2246
GSL + V DSG+Y C A N G ++ KL VV PP I +
Sbjct: 1252 QPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKL-VVYVPPSIR---EDGRK 1307
Query: 2247 IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF------------LTAPYYGSRITVHK 2294
+ + +C A G P PE++W+ + L G + +
Sbjct: 1308 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 1367
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
+L ++ DS + C A N+ G + +L + ++++ G
Sbjct: 1368 GQSLHFPRIQEGDSGLYSCRAENQAGTAQR--DFHLLVLTPPSVLGAGAAQEVLGLAGAD 1425
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI-ISKTTREDAGKYRCAA 2413
L C G P P++ W GP + +G + I+ + D G+Y+C A
Sbjct: 1426 VELQCWTSGVPTPQVEWTKDRQPVLPGGP---HLQVQEDGQVLRITGSHVGDEGRYQCVA 1482
Query: 2414 RNKVGYIEKLVILEIGQKPVIL-TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGY 2472
+ G + L + P I + G V + + L C + G+P PNI W
Sbjct: 1483 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 1542
Query: 2473 VVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITN 2532
+ P L + A + D G Y CKA N+VG + V PP I
Sbjct: 1543 L---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG-AAEKATRLDVYVPPTIEG 1598
Query: 2533 RPPRSIVTR--TGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL 2590
R V + G L CVA G P P ++W H L A + +L G++
Sbjct: 1599 AGGRPYVVKAVAGRPVALECVARGHPSPTLSWH---HEGLPVAESNES----RLETDGSV 1651
Query: 2591 V-IQNPQTSDSGIYKCTAKNPLG 2612
+ +++P + SG+Y C A +P G
Sbjct: 1652 LRLESPGEASSGLYSCVASSPAG 1674
Score = 268 bits (685), Expect = 5e-71
Identities = 254/1005 (25%), Positives = 404/1005 (40%), Gaps = 104/1005 (10%)
Query: 1648 PRIVGGKAASFTIPANSD--AFLPCEAVGNPLPTIHWTR--VPSGLDLSKRKQNSRVQVL 1703
P+I G + + D A L C A G P PT+ W R P G +L + QN
Sbjct: 2256 PQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ----- 2310
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRI--LERRTKEITVHSGS 1761
+L ++R + G+Y C A NL G LSV+ P I L+ T IT S
Sbjct: 2311 -GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN-ITAALHS 2368
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
+ L C A G P P + W + V S G ++ L + D G Y C+
Sbjct: 2369 PLTLLCEAMGIPPPAIRWFRGEEPV----SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCL 2424
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
ASN G+ ++V+ P + E +VI G++ L C G PQP + W DG
Sbjct: 2425 ASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW-FKDG 2483
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
+PL ++ L + S G Y CIA ++ G + + L++ + +P
Sbjct: 2484 ---RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV---LLAP 2537
Query: 1942 RI----EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
I E ++ + V + + L C A P P I W ++ I + P
Sbjct: 2538 TILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRN-----IQLLP 2592
Query: 1998 -NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA--------KIDHKQYFRK 2048
L I + ++D+G Y CV N++G+ + HV + + P+ ++ K+ K
Sbjct: 2593 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTK 2652
Query: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
++C++ P P I W DG + + +R L L
Sbjct: 2653 V---NSTLTLECESWAVPPPTIRW-YKDGQPVTPS---------SRLQVLGEGRLLQIQP 2699
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHL------------------TVITAAPRIRQSNKTN 2150
V++ G Y C A N G+D+ ++ +++ R
Sbjct: 2700 TQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEY 2759
Query: 2151 KRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGE 2210
+ I + A L C+ P P + W + +S + L I V+ ++G
Sbjct: 2760 REIVENNPAYLYCDTNAIPPPDLTW-YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR 2818
Query: 2211 YVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
Y C A N G+D Y+L +V PP+I G T V + T S C A G P P
Sbjct: 2819 YSCKASNEVGEDWLHYEL-LVLTPPVILG-DTEELVEEVTVNASSTVSLQCPALGNPVPT 2876
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNG-TLEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
+ W+ F +P R+ V ++G L++ ++D+A ++CVA N+ G + +L
Sbjct: 2877 ISWLQNGLPFSPSP----RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA---EKLF 2929
Query: 2330 VLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL 2389
L + P E++ A L S +L C V +P PE+ W + S G + +L
Sbjct: 2930 TLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW-YKDSQALSLGEE--VFL 2986
Query: 2390 IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGI---S 2446
+ + + + D+G Y C A N G +KLV L + P G +
Sbjct: 2987 LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV 3046
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRGNY 2504
G+ L C +D +P+P + W Y +P + + L L I+EA D+G Y
Sbjct: 3047 GDKAVLSCETDALPEPTVTW-----YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY 3101
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
CK N G + T + V PP N ++ G+ L C GVP P +TW
Sbjct: 3102 SCKVSNVAGEAVRTF-TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK 3160
Query: 2565 PDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
+ S+A HG + G L + Q + +G Y C A+N
Sbjct: 3161 DRMPVESSA----VHG--VVSRGGRLQLSRLQPAQAGTYTCVAEN 3199
Score = 263 bits (673), Expect = 1e-69
Identities = 261/1035 (25%), Positives = 402/1035 (38%), Gaps = 147/1035 (14%)
Query: 1655 AASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVE 1714
A + T+ A L C +G + W R L S RV L + +L I +
Sbjct: 523 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS----TGRVAQLADLSLEISGII 578
Query: 1715 IQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS 1774
D G+Y C ASN G V L V P + ++ + G V++ C A G P+
Sbjct: 579 PTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPT 636
Query: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVK 1834
P ++W +Q + +S + V GTL++ ++ D G Y C A+N G D V
Sbjct: 637 PHISWSRESQALQEDS-----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 691
Query: 1835 IQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+ PP + V+V GE L C A G P P V W + + +
Sbjct: 692 L-YYTDPPSVSAVNAVVLVAV-GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---- 745
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVN 1954
S+G L I D GTY C A + G + L + +P++ + T V
Sbjct: 746 ---SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH---APQLTELPRDVT-VE 798
Query: 1955 FGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRV--GSWIHVYPNGSLFIGSVTEKDSG 2012
G LL C ATG P P + WR + + GS +G LF SV +D
Sbjct: 799 LGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQA 858
Query: 2013 VYLCVARNKMGDDLILMHVSLRL-----KPAKIDHKQYFRKQVLHGKDFQVDC-KASGSP 2066
Y+C ARN G + RL P +I +VL G+ + C +G P
Sbjct: 859 PYVCEARNVFGK----VQAEARLIVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRP 913
Query: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
+PE W L DG + R+++ +G+L+ ++ G Y+C A NT G
Sbjct: 914 LPERHW-LKDGRPLPPG----------SRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 962
Query: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMIS-- 2184
V L V+ PRI + T+ G A L C +G P P I W +N + S
Sbjct: 963 SQHRDVEL-VVQVPPRIHPT-ATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 1020
Query: 2185 ----------------------------------------FSIDR----------YTFHA 2194
S++R Y
Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLP 1080
Query: 2195 NGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRH 2254
+GSL + +V++ DSG Y C A NP+G + Y L V P + G + ++
Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEAL--- 1137
Query: 2255 SKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICV 2314
+C AEG P P++ W D + L G++ +R SD+ + C
Sbjct: 1138 ---DLNCVAEGNPEPQLSW-SKDGVVLQGR--------GPQGSVHFAAIRTSDAGRYRCE 1185
Query: 2315 ARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQL-GKSTALNCSVDGNPPPEIIWIL 2373
A N G V+L VLE P + ++ ++ G++ +L C G P P++ W
Sbjct: 1186 ASNSAGVDAWEVELRVLE---PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRK 1242
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
+ +G L GS ++ + D+G Y C A N+VG + L + P
Sbjct: 1243 GPSSEPLHGQPGVAVL--EEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPS 1300
Query: 2434 ILTYA-PGTVKGISGESLSLHCVSDGIPKPNIKWTMPS------------GYVVDRPQIN 2480
I V G++G+SL+L C ++G P P I W + G+ + Q+
Sbjct: 1301 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 2481 GKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVT 2540
G +L + +L D G Y C+A+N G ++++ P + + ++
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLG 1420
Query: 2541 RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQ---GTLVIQNPQT 2597
GA +L C GVP P++ W +L G L +Q L I
Sbjct: 1421 LAGADVELQCWTSGVPTPQVEWTKDRQPVLP--------GGPHLQVQEDGQVLRITGSHV 1472
Query: 2598 SDSGIYKCTAKNPLG 2612
D G Y+C A +P G
Sbjct: 1473 GDEGRYQCVAFSPAG 1487
Score = 259 bits (663), Expect = 2e-68
Identities = 256/1006 (25%), Positives = 408/1006 (40%), Gaps = 94/1006 (9%)
Query: 1653 GKAASFTIPANSDAFLPCEAVGNPLPTIHWTR------VP-----SGLDLSKRKQNSRVQ 1701
G+ A+ + A L C+A G P+P I W + VP G DL +
Sbjct: 1305 GRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 1364
Query: 1702 VLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGS 1761
+ +L R++ D G Y C A N GT L V++ P + +E+ +G+
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGA 1424
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG-TLVLHNLSIYDRGFYKC 1820
VEL+C G P+P V W Q V+ G V DG L + + D G Y+C
Sbjct: 1425 DVELQCWTSGVPTPQVEWTKDRQPVL----PGGPHLQVQEDGQVLRITGSHVGDEGRYQC 1480
Query: 1821 VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
VA +P GQ + +++V A P + + ++L C A+G P P++ W D
Sbjct: 1481 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW-FKD 1539
Query: 1881 GTEVKPLQFTNSKLFLFSNG-TLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
G L T++K+ G L + SSD G Y C A+++ G+ + L +
Sbjct: 1540 GA----LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV---YV 1592
Query: 1940 SPRIEAASQKRTEVN--FGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
P IE A + V G + L C A G P P + W V + +
Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES-----RLET 1647
Query: 1998 NGS-LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDF 2056
+GS L + S E SG+Y CVA + G+ ++ V +++ P + + + + G+
Sbjct: 1648 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 1707
Query: 2057 QVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGD 2116
++ C+ASGSPVP I W L +G + T TL+ + V + G
Sbjct: 1708 ELPCQASGSPVPTIQW-LQNGRPAEELAGVQVASQGT---------TLHIDHVELDHSGL 1757
Query: 2117 YTCYAQNTLGKDEMKVHLTV-------ITAAP--RIRQSNKTNKRIKAGDTAVLDCEVTG 2167
+ C A N G +V ++V + P + + + A +
Sbjct: 1758 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 1817
Query: 2168 DPKPKI---------FWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNP 2218
PKP + W P+ +++S+ L I KV L D G Y C A N
Sbjct: 1818 HPKPPLVEGWCSPGSLWGEPTGIPVAYSLP-------PPLQIEKVDLRDEGIYTCAATNL 1870
Query: 2219 SGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDN 2278
+G+ + L V+ PP I N+ V++ +V +C A G P P+V W
Sbjct: 1871 AGESKREVALKVL-VPPNIEPGPVNKAVLENASVT-----LECLASGVPPPDVSWFKGHQ 1924
Query: 2279 IFLTAPYYGSRITVHKNG-TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRP 2337
+ + G +TV +G L I +LSD+ + CVA N G + L L V P
Sbjct: 1925 --PVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV---PP 1977
Query: 2338 TFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI 2397
P + + L C+ G P P ++W L +G S +
Sbjct: 1978 RITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNPVSPAGTPGLQVFPGGRVLT 2036
Query: 2398 ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSD 2457
++ D+G+Y C A + VG + V+L++ P IL V ++ ES++L C S
Sbjct: 2037 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG-EELNVSVVANESVALECQSH 2095
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
+P P + W + RP G ++ D L + A +D G+Y C+A N GH+
Sbjct: 2096 AMPPPVLSWWKDGRPLEPRP---GVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEK 2152
Query: 2518 TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKER 2577
+ V P R ++ R G L C GVP P+I+W L +
Sbjct: 2153 HYN-LNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGA--- 2208
Query: 2578 THGSEQLHLQGTLV-IQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G + + G L+ + Q + G Y C N +G+ ++V
Sbjct: 2209 --GLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 2252
Score = 259 bits (662), Expect = 2e-68
Identities = 251/1020 (24%), Positives = 397/1020 (38%), Gaps = 105/1020 (10%)
Query: 1648 PRIVGG--KAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
P ++G + T +S L CEA+G P P I W R + +L
Sbjct: 2350 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS-----PGEDTYLLAG 2404
Query: 1706 G-TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKE-ITVHSGSTV 1763
G L + + + QD G Y C ASN G + ++ V+ PP I +E I V G T
Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL-VPPSIENEDLEEVIKVLDGQTA 2463
Query: 1764 ELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV-LHNLSIYDRGFYKCVA 1822
L C G P P +TW + + + ++ DG L+ + ++ G Y C+A
Sbjct: 2464 HLMCNVTGHPQPKLTWFKDGRPLARGDAHH-----ISPDGVLLQVLQANLSSAGHYSCIA 2518
Query: 1823 SNPGGQDSLLVKIQVIAAPPVI---LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLS 1879
+N G+ + ++ V+ AP ++ + + + T + L C A P P++ W +
Sbjct: 2519 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MK 2577
Query: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERR---VVMLTMEE 1936
DG P + + + L L I N D G Y C+ T+ G + V +L
Sbjct: 2578 DGA---PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 2634
Query: 1937 RVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVY 1996
+ K + L L C + P P I W + V S + V
Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-----SRLQVL 2689
Query: 1997 PNGSLFIGSVTE-KDSGVYLCVARNKMGDDLILMHVSLRLKPA--KI-DHKQYFR----- 2047
G L T+ DSG YLCVA N G+D +V +++ P K+ D F
Sbjct: 2690 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 2749
Query: 2048 ----------KQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYT 2097
++++ + C + P P+++W D + + G R +
Sbjct: 2750 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIP 2809
Query: 2098 LFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI--KA 2155
L V G Y+C A N +G+D + L V+T + + + + + A
Sbjct: 2810 L----------VRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNA 2859
Query: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCV 2214
T L C G+P P I WL N + R +G L ++ ++ D+ Y+CV
Sbjct: 2860 SSTVSLQCPALGNPVPTISWL--QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCV 2917
Query: 2215 ARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWI 2274
A N +G K++ L V PP I GL + + TA+ +S C P+PEV W
Sbjct: 2918 AENQAGSAEKLFTLRV-QVPPRIAGL----DLEQVTAILNSSVSLPCDVHAHPNPEVTWY 2972
Query: 2275 MPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEML 2334
H TL++ RLSDS + C A N G +VQL VL
Sbjct: 2973 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVP- 3028
Query: 2335 RRPTFRNPFN---EKIVAQLGKSTALNCSVDGNPPPEIIW-------ILPNGTRFSNGPQ 2384
P FR + ++ ++G L+C D P P + W +L T+ G Q
Sbjct: 3029 --PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 3086
Query: 2385 SYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKG 2444
+ I + D G Y C N G + L + P TV
Sbjct: 3087 RLE----------IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ 3136
Query: 2445 ISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNY 2504
++G L L C G+P P + W + V+ ++G ++ G L + G Y
Sbjct: 3137 VAGSPLVLTCDVSGVPAPTVTW-LKDRMPVESSAVHG--VVSRGGRLQLSRLQPAQAGTY 3193
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
C A+N+ V ++ P ++ R G +L C A G P P++ W +
Sbjct: 3194 TCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-L 3252
Query: 2565 PDHSLLSTASKERTHGSEQLHLQ-GTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
D S L + +L G+LV++ + SD+G Y C A NP G D + V+
Sbjct: 3253 KDGSPLGQDMGPHL----RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL 3308
Score = 255 bits (652), Expect = 4e-67
Identities = 275/1040 (26%), Positives = 413/1040 (39%), Gaps = 160/1040 (15%)
Query: 1666 AFLPCEAVGNPLPTIHWTRVPSGL-------DLSKR------------------------ 1694
A LPC A G P PTI WT+ + L ++SK
Sbjct: 993 ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052
Query: 1695 ---KQNSRVQV---------------LPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHV 1736
Q R+ V LP+G+L + +V++ D G Y C+ASN G+
Sbjct: 1053 GFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRY 1112
Query: 1737 TLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQ 1796
L V PP++ + + + V G ++L C AEG P P ++W + QGS
Sbjct: 1113 VLG-VQVPPQV-QPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVH 1170
Query: 1797 AVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTW 1856
+ D G Y+C ASN G D+ V+++V+ P ++ ++
Sbjct: 1171 FAA----------IRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVA 1220
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916
GE+ LPC A+GTP+P V W G +PL + + G+L++ +++ +D G YE
Sbjct: 1221 GENASLPCPARGTPKPQVTW--RKGPSSEPLH-GQPGVAVLEEGSLFLASVSPADSGDYE 1277
Query: 1917 CIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNF-GDKLLLNCSATGEPKPQIMW 1975
C AT+ GS R L + P I +K G L L C A G P P+I+W
Sbjct: 1278 CQATNEVGSTSRRAKLVV---YVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334
Query: 1976 RLPSKAVVDQ-----------QHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGD 2024
++ V +VG + SL + E DSG+Y C A N+ G
Sbjct: 1335 LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT 1394
Query: 2025 DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWS------LPDGT 2078
H+ + P+ + L G D ++ C SG P P++ W+ LP G
Sbjct: 1395 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGP 1454
Query: 2079 MINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVIT 2138
+Q + G L V +EG Y C A + G+ L V
Sbjct: 1455 ----HLQVQEDGQ-----------VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV-H 1498
Query: 2139 AAPRIRQSNKTNKRIKAGDTAV-LDCEVTGDPKPKIFW-----LLPSNDMISFSIDRYTF 2192
A P I SN+T + D V L CE G P P I W LLP++ + ++
Sbjct: 1499 APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYT------ 1552
Query: 2193 HANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAV 2252
L + + + D+G Y C A N G K +LDV PP I G V+KA A
Sbjct: 1553 RGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAG 1611
Query: 2253 RHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFI 2312
R +C A G PSP + W A SR+ L + + + S +
Sbjct: 1612 R--PVALECVARGHPSPTLSW--HHEGLPVAESNESRLET-DGSVLRLESPGEASSGLYS 1666
Query: 2313 CVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWI 2372
CVA + GE+VL +EV + ++ +G+ L C G+P P I W
Sbjct: 1667 CVASSPAGEAVLQYSVEV--QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW- 1723
Query: 2373 LPNGTRFSNGPQSYQYLIASNGSFI-ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQK 2431
L NG + +AS G+ + I + +G + C A N+ G V + + +
Sbjct: 1724 LQNG---RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGE 1780
Query: 2432 PVILTYAPGTVKGISGE---------------SLSLHCVSDGIPKPNI--KWTMPSGYVV 2474
+APG ++ G+ +H PKP + W P
Sbjct: 1781 -----WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWG 1835
Query: 2475 DRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRP 2534
+ I Y L L I++ D G Y C A N G + V + ++ PP I P
Sbjct: 1836 EPTGIPVAYSLPP--PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV-PPNIEPGP 1892
Query: 2535 PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQG-TLVIQ 2593
V A+ L C+A GVP P+++W H +S+ + + G L I+
Sbjct: 1893 VNKAVLE-NASVTLECLASGVPPPDVSW-FKGHQPVSSWM------GVTVSVDGRVLRIE 1944
Query: 2594 NPQTSDSGIYKCTAKNPLGS 2613
Q SD+G Y+C A N GS
Sbjct: 1945 QAQLSDAGSYRCVASNVAGS 1964
Score = 246 bits (629), Expect = 2e-64
Identities = 251/990 (25%), Positives = 392/990 (39%), Gaps = 95/990 (9%)
Query: 1663 NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYL 1722
N+ L C A G P P + W + G V V L I++ ++ D G Y
Sbjct: 1900 NASVTLECLASGVPPPDVSWFK---GHQPVSSWMGVTVSV-DGRVLRIEQAQLSDAGSYR 1955
Query: 1723 CSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILA 1782
C ASN+ G+ L L V+ PPRI + V + V L C A G PSPT+ W+
Sbjct: 1956 CVASNVAGSTELRYGLR-VNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKD 2014
Query: 1783 NQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP 1842
V + G + V L L + D G Y CVA + G+D V +QV P
Sbjct: 2015 GNPVSPAGTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 2072
Query: 1843 VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTL 1902
++ E+ +V ES+ L C + P P + W DG +PL+ L
Sbjct: 2073 ILGEELNVSVVA--NESVALECQSHAMPPPVLSW-WKDG---RPLEPRPGVHLSADKALL 2126
Query: 1903 YIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLN 1962
+ D G Y C A + G + L + +P V G L+
Sbjct: 2127 QVDRADVWDAGHYTCEALNQAGHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLS 2183
Query: 1963 CSATGEPKPQIMWRLPSKAVVDQQHRVGSWI-HVYPNGS-LFIGSVTEKDSGVYLCVARN 2020
C G P P+I WR + + + G+ + HV G L++G G Y C N
Sbjct: 2184 CECRGVPFPKISWRKDGQPLPGE----GAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN 2239
Query: 2021 KMGDDLILMHVSLRLKPAKIDHKQ-YFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTM 2079
+G+ + + + + P ++ + V+ ++C A+G P P ++W DG
Sbjct: 2240 VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE-RDGQP 2298
Query: 2080 INN--AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVI 2137
+ +Q + G +L+ + A G Y+C A+N G+ E K L+V+
Sbjct: 2299 VGAELGLQLQNQGQ-----------SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL 2347
Query: 2138 TAAPRIRQSNK-TNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
I + TN L CE G P P I W + +S D Y
Sbjct: 2348 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW-FRGEEPVSPGEDTYLLAGGW 2406
Query: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
L + + + DSG Y C+A N +G+ + + ++V+ P + N VIK +
Sbjct: 2407 MLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIK--VLDGQT 2462
Query: 2257 KHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT-LEIRNVRLSDSADFICVA 2315
H C G P P++ W G + +G L++ LS + + C+A
Sbjct: 2463 AHLMCNVTGHPQPKLTWFKDGRPLAR----GDAHHISPDGVLLQVLQANLSSAGHYSCIA 2518
Query: 2316 RNEGGESVLVVQLEVLEMLRRPTF----RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIW 2371
N GE QL V L PT + +E++ + +L C P P I W
Sbjct: 2519 ANAVGEKTKHFQLSV---LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW 2575
Query: 2372 ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG------YIEKLVI 2425
+ +G F ++ Q L ++G I++ +EDAG+Y C N++G ++E L+
Sbjct: 2576 -MKDGAPF-EASRNIQLLPGTHGLQILN-AQKEDAGQYTCVVTNELGEAVKNYHVEVLIP 2632
Query: 2426 LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYIL 2485
I + + VK +L+L C S +P P I+W V ++ +L
Sbjct: 2633 PSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ---VL 2689
Query: 2486 HDNGTLVIKEATAYDRGNYICKAQNSVG------HTLITVPVMI-------VAYPPRITN 2532
+ L I+ D G Y+C A N G + LI VP M A+
Sbjct: 2690 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 2749
Query: 2533 RPPRSIVTRTGAAFQ-----LHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQ 2587
R VT + L+C +P P++TW D L + G E LQ
Sbjct: 2750 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL--------SAGDEVSVLQ 2801
Query: 2588 GTLVIQNP--QTSDSGIYKCTAKNPLGSDY 2615
G V+Q P + ++G Y C A N +G D+
Sbjct: 2802 GGRVLQIPLVRAENAGRYSCKASNEVGEDW 2831
Score = 245 bits (625), Expect = 5e-64
Identities = 218/795 (27%), Positives = 330/795 (41%), Gaps = 78/795 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
P I G A + N A LPC+A G P P + W + LD ++ R ++LP G+
Sbjct: 3673 PTIRSGPPA-VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD----PRSPRFEILPEGS 3727
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L IQ V QD G YLC ASN G+D L V+ P +T H+ + L C
Sbjct: 3728 LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPAL--LPC 3785
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG 1827
A G P P V W Q + QG+ + + + L+L D ++CV SN G
Sbjct: 3786 EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS--NALLLTAPGPQDSAQFECVVSNEVG 3843
Query: 1828 QDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPL 1887
+ L ++ V PP I + + V T + L C + G P P+V W + L
Sbjct: 3844 EAHRLYQVTV-HVPPTIADDQTDFTV-TMMAPVVLTCHSTGIPAPTVSWSKAGAQ----L 3897
Query: 1888 QFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAAS 1947
S + +G L I G Y C A +S G + V LT++ + +
Sbjct: 3898 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVV 3957
Query: 1948 QKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007
+ E +++LL C A+G P+P I W+ V G V P G L I +
Sbjct: 3958 RAVAE----EEVLLPCEASGIPRPTITWQKEGLNVA-----TGVSTQVLPGGQLRIAHAS 4008
Query: 2008 EKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
+D+G YLC+A+N G + + +++ P + G + CKA GSP
Sbjct: 4009 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPP--VIENGLPDLSTTEGSHAFLPCKARGSPE 4066
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P I+W DG ++ A ++T+ +G L + + G YTC A+N +G+
Sbjct: 4067 PNITWD-KDGQPVSGA---------EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR 4116
Query: 2128 DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSI 2187
+VHLT++ + + ++ ++ GD L C G P P+I W + ND +
Sbjct: 4117 ARRRVHLTILVLP--VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV--NDR---PV 4169
Query: 2188 DRYTFHANGSLTINK--VKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRT 2245
+G T+ + V DSG YVC A N G + + V P L ++
Sbjct: 4170 TEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLV 4229
Query: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVH-KNGTLEIRNVR 2304
+++ DC G P P++ WI P GS + +NG+L I
Sbjct: 4230 EPVGGSIQ-----LDCVVRGDPVPDIHWIKDG-----LPLRGSHLRHQLQNGSLTIHRTE 4279
Query: 2305 LSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGN 2364
D+ + C+A NE G + VV +L + P F+ + V G AL C G
Sbjct: 4280 RDDAGRYQCLAENEMGVAKKVV---ILVLQSAPVFQVEPQDMTVRS-GDDVALRCQATGE 4335
Query: 2365 PPPEIIWILPNGTRFSNGPQSYQYLIAS-------NGSFIISKTTREDAGKYRCAARNKV 2417
P P I W+ Q+ Q L AS +GS + DAG Y C A N +
Sbjct: 4336 PTPTIEWL-----------QAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLL 4384
Query: 2418 GYIEKLVILEIGQKP 2432
G L + +P
Sbjct: 4385 GSATARAFLVVRGEP 4399
Score = 231 bits (588), Expect = 9e-60
Identities = 249/1005 (24%), Positives = 396/1005 (39%), Gaps = 96/1005 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG- 1706
PRI + + N+ L C A G P PT+ W + G +S +QV P G
Sbjct: 1977 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DGNPVSP-AGTPGLQVFPGGR 2033
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELK 1766
L++ D G+Y C A + G D V L V PP IL ++V + +V L+
Sbjct: 2034 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQ-VHMPPSILGEEL-NVSVVANESVALE 2091
Query: 1767 CRAEGRPSPTVTWILANQTVVSESS--QGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
C++ P P ++W + + + +A++ VD ++D G Y C A N
Sbjct: 2092 CQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVD------RADVWDAGHYTCEALN 2145
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G + V AP L + + V G L C +G P P + W DG
Sbjct: 2146 QAGHSEKHYNLNVWVAPVFPLRESHTLTVRE-GHPTSLSCECRGVPFPKISW-RKDG--- 2200
Query: 1885 KPLQFTNSKLFLFS--NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
+PL + L S LY+ + GTY C ++ G+ + + L + P+
Sbjct: 2201 QPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH---VPPQ 2257
Query: 1943 IEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS 2000
I + T+V+ L C+ATG+P P + W + V + +G + S
Sbjct: 2258 IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE---LGLQLQ-NQGQS 2313
Query: 2001 LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK--QVLHGKDFQV 2058
L + +G Y CVA N G +S+ + P I LH +
Sbjct: 2314 LHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALH-SPLTL 2372
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
C+A G P P I W + G T Y L L + + G Y+
Sbjct: 2373 LCEAMGIPPPAIRWF--------RGEEPVSPGEDT--YLLAGGWMLKMTQTQEQDSGLYS 2422
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A N G+ + V+ + + ++ G TA L C VTG P+PK+ W
Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 2482
Query: 2179 SNDMISFSIDRYTFHANG-SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
+ D + +G L + + L +G Y C+A N G+ TK ++L V+ P ++
Sbjct: 2483 GRPLARG--DAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 2540
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
G + + T ++ C A PSP + W M D AP+ SR GT
Sbjct: 2541 GGAEDSADE-EVTVTVNNPISLICEALAFPSPNITW-MKDG----APFEASRNIQLLPGT 2594
Query: 2298 --LEIRNVRLSDSADFICVARNEGGESVLVVQLEVL---EMLRRPTFRNPFNEKIVAQLG 2352
L+I N + D+ + CV NE GE+V +EVL + + +++ ++
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654
Query: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
+ L C PPP I W +G + P S ++ I T D+G+Y C
Sbjct: 2655 STLTLECESWAVPPPTIRW-YKDGQPVT--PSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 2711
Query: 2413 ARNKVGYIEKLVILEIGQKPV------------ILTYAPGTVKGIS-------GESLSLH 2453
A N G ++ + I P+ IL+ G++ L+
Sbjct: 2712 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 2771
Query: 2454 CVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRGNYICKAQNS 2511
C ++ IP P++ W Y D+P G +L L I A + G Y CKA N
Sbjct: 2772 CDTNAIPPPDLTW-----YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE 2826
Query: 2512 VGHTLITVPVMIVAYPPRI---TNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHS 2568
VG + ++++ PP I T + + L C ALG P P I+W + +
Sbjct: 2827 VGEDWLHYELLVLT-PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGL 2884
Query: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
S + + + Q+ L + + +D+ Y C A+N GS
Sbjct: 2885 PFSPSPRLQVLEDGQV-----LQVSTAEVADAASYMCVAENQAGS 2924
Score = 210 bits (534), Expect = 2e-53
Identities = 213/788 (27%), Positives = 311/788 (39%), Gaps = 126/788 (15%)
Query: 1899 NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDK 1958
N + I + ++ GTYEC A S G+ R + VT P + V+ G+
Sbjct: 478 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGET 533
Query: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
+L+C GE + W + + RV + SL I + D G Y CVA
Sbjct: 534 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL----SLEISGIIPTDGGRYQCVA 589
Query: 2019 RNKMGDDLILMHVSLRLKPAKIDH--KQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPD 2076
N G + + +R P H Q+F + G + +V C ASG P P ISWS
Sbjct: 590 SNANGVTRASVWLLVREAPQVSIHTSSQHFSQ----GVEVKVSCSASGYPTPHISWSRE- 644
Query: 2077 GTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV 2136
+ A+Q D H + GTL V + G+Y+C A N +G D+ V L
Sbjct: 645 ----SQALQEDSRIHVDAQ------GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL-Y 693
Query: 2137 ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
T P + N + G+ AVL CE +G P P++ W +MI ++G
Sbjct: 694 YTDPPSVSAVNAV-VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSG 748
Query: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
L I + D+G Y C A N GD + +L V P + L + TV + +
Sbjct: 749 KLRIPAAQERDAGTYTCRAVNELGDASAEIQL-AVGHAPQLTELPRDVTVELGRSALLA- 806
Query: 2257 KHFDCRAEGTPSPEVMWIMPDNIFL---TAPYYGSRITVHKNGTLEIRNVRLSDSADFIC 2313
CRA G P P V W D L GSR +G L +V D A ++C
Sbjct: 807 ----CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 862
Query: 2314 VARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSV-DGNPPPEIIWI 2372
ARN G+ +L V + +++ G+ +L C V G P PE W+
Sbjct: 863 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWL 920
Query: 2373 -----LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILE 2427
LP G+R S I ++GS + + +E AG+Y C A N G + V L
Sbjct: 921 KDGRPLPPGSRHS---------IRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 971
Query: 2428 IGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHD 2487
+ P I A + G SL CV+ G+P P I WT + + R Y +
Sbjct: 972 VQVPPRIHPTATHHITN-EGVPASLPCVASGVPAPTITWTKETNALTSR---GPHYNVSK 1027
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSV----------------------------------- 2512
GTL+I + +A D G Y+C A N+V
Sbjct: 1028 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLA 1087
Query: 2513 -------GHTLITVP----------VMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGV 2555
GH T V+ V PP++ PR + G A L+CVA G
Sbjct: 1088 QVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQV-QPGPRVLKVLVGEALDLNCVAEGN 1146
Query: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
P+P+++W L QG++ +TSD+G Y+C A N G D
Sbjct: 1147 PEPQLSWSKDGVVLQGRGP------------QGSVHFAAIRTSDAGRYRCEASNSAGVDA 1194
Query: 2616 AATYIQVI 2623
++V+
Sbjct: 1195 WEVELRVL 1202
Score = 207 bits (527), Expect = 1e-52
Identities = 246/1011 (24%), Positives = 382/1011 (37%), Gaps = 119/1011 (11%)
Query: 1644 IFEKPRIVGGKAASFTIPA--NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQ 1701
++ P I G + + A L C A G+P PT+ W GL +++ + SR++
Sbjct: 1590 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH--EGLPVAESNE-SRLE 1646
Query: 1702 VLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGS 1761
L ++ G Y C AS+ G L ++ V P ++ ++T G
Sbjct: 1647 T-DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 1705
Query: 1762 TVELKCRAEGRPSPTVTWILANQTV-----VSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
+EL C+A G P PT+ W+ + V +SQG+ TL + ++ + G
Sbjct: 1706 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT---------TLHIDHVELDHSG 1756
Query: 1817 FYKCVASNPGGQDSLLVKIQVIA--APPVILEQRRQVIVGT--WGESLKLPCTAKGTPQP 1872
+ C A+N G V++ V AP V+ +V +G WG A P
Sbjct: 1757 LFACQATNEAGTAGAEVEVSVHGEWAPGVL-----EVPIGQYHWGXEHHSSFPAACDPPV 1811
Query: 1873 SVYWVLSDGTEVKP--LQFTNSKLFLFSNGT-----------LYIRNLASSDRGTYECIA 1919
W G KP ++ S L+ T L I + D G Y C A
Sbjct: 1812 HRGW----GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAA 1867
Query: 1920 TSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPS 1979
T+ G +R V L + + P IE + + + L C A+G P P + W
Sbjct: 1868 TNLAGESKREVALKV---LVPPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSW---- 1919
Query: 1980 KAVVDQQHRVGSWIHV---YPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLK 2036
V SW+ V L I D+G Y CVA N G + + + +
Sbjct: 1920 ---FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV- 1975
Query: 2037 PAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRY 2096
P +I VL ++ C A+G+P P + W L DG ++ A T
Sbjct: 1976 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNPVSPA--------GTPGL 2026
Query: 2097 TLFNNG-TLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKA 2155
+F G L ++ G Y+C A + +G+D V L V P + N + A
Sbjct: 2027 QVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILGEELNVSVVA 2084
Query: 2156 GDTAVLDCEVTGDPKPKIFWL-----LPSNDMISFSIDRYTFHANGSLTINKVKLLDSGE 2210
++ L+C+ P P + W L + S D+ L +++ + D+G
Sbjct: 2085 NESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK------ALLQVDRADVWDAGH 2138
Query: 2211 YVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
Y C A N +G K Y L+V P ++ R T C G P P+
Sbjct: 2139 YTCEALNQAGHSEKHYNLNVWVAP-----VFPLRESHTLTVREGHPTSLSCECRGVPFPK 2193
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
+ W D L G + L + +L+ + C N G S +QLEV
Sbjct: 2194 ISW-RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 2252
Query: 2331 LEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLI 2390
+ R P + V Q G +T L C+ G PPP + W G + L
Sbjct: 2253 HVPPQIAGPREPPTQVSVVQDGVAT-LECNATGKPPPTVTW---ERDGQPVGAELGLQLQ 2308
Query: 2391 ASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESL 2450
S + + G+Y C A N G E+ L + P ++ G + ++ +
Sbjct: 2309 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELI----GDLDPLTNITA 2364
Query: 2451 SLH------CVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRG 2502
+LH C + GIP P I+W + + P G+ Y+L L + + D G
Sbjct: 2365 ALHSPLTLLCEAMGIPPPAIRW-----FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 2419
Query: 2503 NYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIV-TRTGAAFQLHCVALGVPKPEIT 2561
Y C A N G V ++ PP I N ++ G L C G P+P++T
Sbjct: 2420 LYSCLASNEAGEARRNFSVEVLV-PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT 2478
Query: 2562 WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
W L A + H S L L + S +G Y C A N +G
Sbjct: 2479 WFKDGRPL---ARGDAHHISPDGVL---LQVLQANLSSAGHYSCIAANAVG 2523
Score = 164 bits (416), Expect = 8e-40
Identities = 117/400 (29%), Positives = 187/400 (46%), Gaps = 33/400 (8%)
Query: 1641 SRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRV 1700
+R + + P ++ + S AFLPC+A G+P P I W + G +S + +
Sbjct: 4030 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTI 4087
Query: 1701 QVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSG 1760
Q P+G L ++ +E QD G Y C+A N G V L+++ P + + ++ G
Sbjct: 4088 Q--PSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP--VFTTLPGDRSLRLG 4143
Query: 1761 STVELKCRAEGRPSPTVTWILANQTV---VSESSQGSRQAVVTVDGTLVLHNLSIYDRGF 1817
+ L+C A G P+P + W + ++ V VSE GS TL +S D G
Sbjct: 4144 DRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGS---------TLQRAAVSREDSGT 4194
Query: 1818 YKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWV 1877
Y C A N G+ + + V A PV+ + +V G S++L C +G P P ++W+
Sbjct: 4195 YVCWAENRVGRTQAVSFVHVKEA-PVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWI 4253
Query: 1878 LSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEER 1937
DG ++ + NG+L I D G Y+C+A + G ++VV+L ++
Sbjct: 4254 -KDGLPLRGSHLRHQ----LQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ-- 4306
Query: 1938 VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
++P + Q T V GD + L C ATGEP P I W Q R + P
Sbjct: 4307 -SAPVFQVEPQDMT-VRSGDDVALRCQATGEPTPTIEW-----LQAGQPLRASRRLRTLP 4359
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP 2037
+GSL++ +V D+G Y CVA N +G + +R +P
Sbjct: 4360 DGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 163 bits (412), Expect = 2e-39
Identities = 170/661 (25%), Positives = 263/661 (39%), Gaps = 58/661 (8%)
Query: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
LL++CS ++ R + +++H S N S I ++ + G Y C A
Sbjct: 444 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESG-----NSSWEILRASKAEEGTYECTA 498
Query: 2019 RNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGT 2078
++ G + + P ++ V G+ + C+ G ++W + D
Sbjct: 499 VSRAGTGRAKAQIVVTDPPPQLVPAP--NVTVSPGETAVLSCRVLGEAPYNLTW-VRDWR 555
Query: 2079 MINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVIT 2138
++ + T R + +L + + + G Y C A N G V L ++
Sbjct: 556 VLPAS---------TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL-LVR 605
Query: 2139 AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSL 2198
AP++ + +++ G + C +G P P I W S + S R A G+L
Sbjct: 606 EAPQV-SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS--RIHVDAQGTL 662
Query: 2199 TINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
I V D+G Y C A N G D + L + PP ++ + N V+ A +
Sbjct: 663 IIQGVAPEDAGNYSCQATNEVGTDQETVTL-YYTDPPSVSAV--NAVVLVAVG---EEAV 716
Query: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
C A G P P V+W + AP S +G L I + D+ + C A NE
Sbjct: 717 LVCEASGVPPPRVIWYRGGLEMILAPEGSS------SGKLRIPAAQERDAGTYTCRAVNE 770
Query: 2319 GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL----P 2374
G++ +QL V + + +LG+S L C G PPP + W P
Sbjct: 771 LGDASAEIQLAVGHAPQL----TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 826
Query: 2375 NGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIE-KLVILEIGQKPV 2433
G R G S +G ED Y C ARN G ++ + ++ G P
Sbjct: 827 LGLRLGAGRGSRSRQ-PDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 885
Query: 2434 ILTYAPGTVKGISGESLSLHC-VSDGIPKPNIKWTMPSGYVVDRPQING-KYILHDNGTL 2491
+ + TV+ + G+ +SL C V G P P W RP G ++ + +G+L
Sbjct: 886 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG-----RPLPPGSRHSIRADGSL 940
Query: 2492 VIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCV 2551
+ A G Y C A N+ G V ++V PPRI I T G L CV
Sbjct: 941 HLDRALQEHAGRYSCVATNTAGSQHRDVE-LVVQVPPRIHPTATHHI-TNEGVPASLPCV 998
Query: 2552 ALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPL 2611
A GVP P ITW ++L S + +GTL+I P D+G Y CTA N +
Sbjct: 999 ASGVPAPTITWTKETNALTSRGP------HYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052
Query: 2612 G 2612
G
Sbjct: 1053 G 1053
Score = 160 bits (406), Expect = 1e-38
Identities = 143/527 (27%), Positives = 214/527 (40%), Gaps = 37/527 (7%)
Query: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI 2153
R + N + + AEEG Y C A + G K + V P++ + N +
Sbjct: 471 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 528
Query: 2154 KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVC 2213
G+TAVL C V G+ + W+ ++ S R A+ SL I+ + D G Y C
Sbjct: 529 SPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQC 587
Query: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMW 2273
VA N +G L +V + P ++ +++ + V+ S C A G P+P + W
Sbjct: 588 VASNANGVTRASVWL-LVREAPQVSIHTSSQHFSQGVEVKVS-----CSASGYPTPHISW 641
Query: 2274 IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
A SRI V GTL I+ V D+ ++ C A NE G V L +
Sbjct: 642 SRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD- 696
Query: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASN 2393
P + N ++ +G+ L C G PPP +IW G P+ +S+
Sbjct: 697 ---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-GGLEMILAPEG-----SSS 747
Query: 2394 GSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLH 2453
G I DAG Y C A N++G + L +G P LT P V G S L
Sbjct: 748 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-LTELPRDVTVELGRSALLA 806
Query: 2454 CVSDGIPKPNIKWTMPSGYVVDRPQINGKYILH---DNGTLVIKEATAYDRGNYICKAQN 2510
C + G P P + W G + G+ D+G L + D+ Y+C+A+N
Sbjct: 807 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866
Query: 2511 SVGHTLITVPVMIVAY-PPRITNRPPRSIVTRTGAAFQLHCVAL-GVPKPEITWEMPDHS 2568
G +++ + PP+I + P ++ G L C+ L G P PE W + D
Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRPLPERHW-LKDGR 924
Query: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
L S+ LHL L +G Y C A N GS +
Sbjct: 925 PLPPGSRHSIRADGSLHLDRAL------QEHAGRYSCVATNTAGSQH 965
Score = 73.6 bits (179), Expect = 2e-12
Identities = 62/231 (26%), Positives = 103/231 (44%), Gaps = 21/231 (9%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGV 548
VGG++ L+C +GDP P + W + DG +R ++ ++G L + + D G
Sbjct: 4232 VGGSIQLDCVVRGDPVPDIHW-IKDGLPLRGSHLRHQ-----LQNGSLTIHRTERDDAGR 4285
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
Y C++ N + + + +V +Q TV G+ + L C +TG P +I W+
Sbjct: 4286 YQCLAEN--EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL 4343
Query: 609 IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQR 668
G + ++SR + L +G+L + V D G Y CVA N G +
Sbjct: 4344 QAGQPL--RASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG----------SATARA 4391
Query: 669 PLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRH 719
L GE +GS + + ++ A L TS + EA G + +S RH
Sbjct: 4392 FLVVRGEPQGS-WGSMTGVINGRKFGVATLNTSVMQEAHSGVSSIHSSIRH 4441
Score = 71.2 bits (173), Expect = 1e-11
Identities = 61/192 (31%), Positives = 87/192 (45%), Gaps = 11/192 (5%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKV---RAPYVSEDGRILIDKS 533
R + EH VL G V L+C G P P V W L DGS + P++ R +D
Sbjct: 3219 RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSPLGQDMGPHL----RFYLD-G 3272
Query: 534 GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVF-IGETLD 592
G L L+ + D G Y C++ N D + + V+ P +G V GE +
Sbjct: 3273 GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVT 3332
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ C G P +SW+ G L S R + TLRI +V D G + CVAA+P+G
Sbjct: 3333 MVCPVRGSPPIHVSWLKDG-LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 3391
Query: 653 VDFLIFQVSVKM 664
V F + V++
Sbjct: 3392 VADRNFTLQVQV 3403
Score = 70.9 bits (172), Expect = 2e-11
Identities = 48/168 (28%), Positives = 68/168 (40%), Gaps = 15/168 (8%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDK--SGKLELQMADSF 544
VLVG + LNC +G+P P + W S+DG +L + G + +
Sbjct: 1131 VLVGEALDLNCVAEGNPEPQLSW-------------SKDGVVLQGRGPQGSVHFAAIRTS 1177
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
D G Y C +SN D + V+EP E GE LPC + G P
Sbjct: 1178 DAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQ 1237
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
++W ++ VL G+L + V+P D G Y C A N G
Sbjct: 1238 VTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 1285
Score = 67.0 bits (162), Expect = 2e-10
Identities = 53/174 (30%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
+ TV + V L C G P P V W SK A + + SG LE+ A
Sbjct: 3865 DFTVTMMAPVVLTCHSTGIPAPTVSW-----SKAGAQLGARGSGYRVSPSGALEIGQALP 3919
Query: 544 FDTGVYHCISSN-----YDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHST 598
G Y C + N + + VV+PL + E + LPC ++
Sbjct: 3920 IHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVR-------AVAEEEVLLPCEAS 3972
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
GIP +I+W G NV S +VL G LRI +P+D G Y C+A N +G
Sbjct: 3973 GIPRPTITWQKEGLNVATGVST--QVLPGGQLRIAHASPEDAGNYLCIAKNSAG 4024
Score = 66.2 bits (160), Expect = 4e-10
Identities = 56/189 (29%), Positives = 84/189 (44%), Gaps = 17/189 (8%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E TV V + L C P+P++ W+ K AP+ + L+ + L++ A
Sbjct: 2550 EVTVTVNNPISLICEALAFPSPNITWM-----KDGAPFEASRNIQLLPGTHGLQILNAQK 2604
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLV----EAYQENGIHHT-VFIGETLDLPCHST 598
D G Y C+ +N + Y + V+ P + E G+ + TL L C S
Sbjct: 2605 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW 2664
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP---KDQGYYRCVAANPSGVDF 655
+P +I W G V SSR +VL G R+LQ+ P D G Y CVA N +G D
Sbjct: 2665 AVPPPTIRWYKDGQPVT-PSSR-LQVLGEG--RLLQIQPTQVSDSGRYLCVATNVAGEDD 2720
Query: 656 LIFQVSVKM 664
F V +++
Sbjct: 2721 QDFNVLIQV 2729
Score = 65.1 bits (157), Expect = 9e-10
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 9/191 (4%)
Query: 479 NNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LE 537
+N E V+ V L C +G PTP++ W DG+ + +++ + G+ L+
Sbjct: 1506 SNETGEVAVMEDHLVQLLCEARGVPTPNITWF-KDGA-----LLPTSTKVVYTRGGRQLQ 1559
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCH 596
L A S D GVY C +SN A R+ V V P +E G + L C
Sbjct: 1560 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECV 1619
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFL 656
+ G P ++SW G V +S+ + + LR+ G Y CVA++P+G L
Sbjct: 1620 ARGHPSPTLSWHHEGLPVA-ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVL 1678
Query: 657 IFQVSVKMKGQ 667
+ V V++ Q
Sbjct: 1679 QYSVEVQVPPQ 1689
Score = 64.7 bits (156), Expect = 1e-09
Identities = 47/168 (27%), Positives = 80/168 (47%), Gaps = 10/168 (5%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSFDT 546
L G + L C + +P P + W DG ++ ED + G+ L+LQ + D+
Sbjct: 3594 LAPGQLVLECSVEAEPAPKITWH-RDGIVLQ-----EDAHTQFPERGRFLQLQALSTADS 3647
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C + N + + +R+ + V + V + +T LPC + G+P +S
Sbjct: 3648 GDYSCTARNAAGSTSVAFRVEI--HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVS 3705
Query: 607 WVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
W + +S R + +L G+LRI V +D G+Y C+A+N +G D
Sbjct: 3706 WRKDRVPLDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 3752
Score = 64.3 bits (155), Expect = 2e-09
Identities = 50/172 (29%), Positives = 71/172 (41%), Gaps = 13/172 (7%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADG--SKVRAPYVSEDGRILIDKSGKLELQMADSF 544
VL +V L C G P P V W S VS DGR+L ++ A
Sbjct: 1897 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVL-------RIEQAQLS 1949
Query: 545 DTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
D G Y C++SN + L Y + V V P + + V + + L C++TG P
Sbjct: 1950 DAGSYRCVASNVAGSTELRYGLRVNVPPRITL--PPSLPGPVLVNTPVRLTCNATGAPSP 2007
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVD 654
++ W+ GN V + +V G L + D G Y CVA + G D
Sbjct: 2008 TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 2059
Score = 63.5 bits (153), Expect = 3e-09
Identities = 45/163 (27%), Positives = 67/163 (41%), Gaps = 12/163 (7%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G V ++C G PTPH+ W + + ED RI +D G L +Q D G Y
Sbjct: 622 GVEVKVSCSASGYPTPHISW------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 675
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C ++N D T + +P + V +GE L C ++G+P + W
Sbjct: 676 SCQATNEVGTDQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR 733
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
G ++ ++G LRI +D G Y C A N G
Sbjct: 734 GGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCRAVNELG 772
Score = 62.4 bits (150), Expect = 6e-09
Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 8/176 (4%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
+ G V L C +G P+P + W +G V S + R+ D S L L+ +G
Sbjct: 1609 VAGRPVALECVARGHPSPTLSWH-HEGLPVAE---SNESRLETDGS-VLRLESPGEASSG 1663
Query: 548 VYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
+Y C++S+ +L Y + V P E T +G+ L+LPC ++G P +I W
Sbjct: 1664 LYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 1723
Query: 608 VIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+ G + +V + G TL I V G + C A N +G +VSV
Sbjct: 1724 LQNGRPA--EELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 1777
Score = 61.6 bits (148), Expect = 1e-08
Identities = 49/176 (27%), Positives = 80/176 (45%), Gaps = 16/176 (9%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G V + CP +G P HV WL K P +L L + D G++
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWL-----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIF 3382
Query: 550 HCISSNYDDADILTYRITV-VEPLVEAYQ-ENGIHHTVFIGETLDLPCHSTGIPDASISW 607
C++++ + + V V P++E + +N + V G ++LPC + G+P +SW
Sbjct: 3383 TCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDV--VVVRGSLVELPCEARGVPLPLVSW 3440
Query: 608 VIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+ G +L QS L G +L++ V D G Y CVA + +G FQ++V
Sbjct: 3441 MKDGEPLLSQS------LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 3490
Score = 61.6 bits (148), Expect = 1e-08
Identities = 60/194 (30%), Positives = 81/194 (41%), Gaps = 15/194 (7%)
Query: 476 SRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK 535
S N T HT + L C G P P V W DG K+ + + G + S
Sbjct: 3769 SPSNLTLTAHTPAL-----LPCEASGSPKPLVVWW-KDGQKL--DFRLQQGAYRLLPSNA 3820
Query: 536 LELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC 595
L L D+ + C+ SN Y++TV P A + TV + + L C
Sbjct: 3821 LLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDF--TVTMMAPVVLTC 3878
Query: 596 HSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD- 654
HSTGIP ++SW G + + S +V +G L I Q P G Y C A N +GV
Sbjct: 3879 HSTGIPAPTVSWSKAGAQLGARGS-GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 3937
Query: 655 ---FLIFQVSVKMK 665
FL Q S +K
Sbjct: 3938 KHVFLTVQASPVVK 3951
Score = 61.2 bits (147), Expect = 1e-08
Identities = 48/177 (27%), Positives = 75/177 (42%), Gaps = 8/177 (4%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V T L C G P P V W K R P R I G L +Q + D
Sbjct: 3684 VSVNQTALLPCQADGVPAPLVSW-----RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDA 3738
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C++SN +D + V+EP A + + T+ LPC ++G P +
Sbjct: 3739 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL--TLTAHTPALLPCEASGSPKPLVV 3796
Query: 607 WVIPGNNVLYQSSRDK-KVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
W G + ++ + ++L + L + P+D + CV +N G ++QV+V
Sbjct: 3797 WWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTV 3853
Score = 60.5 bits (145), Expect = 2e-08
Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 21/179 (11%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V+ G V L C +G P P V W+ DG P +S+ +++ L+L+ + D+
Sbjct: 3418 VVRGSLVELPCEARGVPLPLVSWM-KDGE----PLLSQS----LEQGPSLQLEAVGAGDS 3468
Query: 547 GVYHCISSNYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C++ + +++TV+EP + ++ Q + T G ++L C + G P +
Sbjct: 3469 GTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTP--GAPMELLCDAQGTPQPN 3526
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
I+W G + + N+ R+L+V +D G Y C+A +P+G F+V V+
Sbjct: 3527 ITWHKDGQALTRLEN------NSRATRVLRV--RDAGLYTCLAESPAGAIEKSFRVRVQ 3577
Score = 59.3 bits (142), Expect = 5e-08
Identities = 48/183 (26%), Positives = 77/183 (42%), Gaps = 15/183 (8%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAP--YVSEDGRILIDKSGKLELQMA 541
E TV TV L CP G+P P + WL +P V EDG++ L++ A
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQV-------LQVSTA 2906
Query: 542 DSFDTGVYHCISSNYDDA--DILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
+ D Y C++ N + + T R+ V P + + T + ++ LPC
Sbjct: 2907 EVADAASYMCVAENQAGSAEKLFTLRVQ-VPPRIAGLDLEQV--TAILNSSVSLPCDVHA 2963
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQ 659
P+ ++W + L + TL++ + D G Y C A N +G D + Q
Sbjct: 2964 HPNPEVTW-YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 3022
Query: 660 VSV 662
+SV
Sbjct: 3023 LSV 3025
Score = 58.9 bits (141), Expect = 6e-08
Identities = 51/203 (25%), Positives = 80/203 (39%), Gaps = 24/203 (11%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAP-----------YVSED 525
R++ K + + G ++ L C G P P + WL D V P +
Sbjct: 1302 REDGRKANVSGMAGQSLTLECDANGFPVPEIVWL-KDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 526 GRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTV 585
G L+D+ L D+G+Y C + N + + V+ P
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLG 1420
Query: 586 FIGETLDLPCHSTGIPDASISW------VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKD 639
G ++L C ++G+P + W V+PG L Q D +VL RI D
Sbjct: 1421 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHL-QVQEDGQVL-----RITGSHVGD 1474
Query: 640 QGYYRCVAANPSGVDFLIFQVSV 662
+G Y+CVA +P+G FQ+ V
Sbjct: 1475 EGRYQCVAFSPAGQQARDFQLRV 1497
Score = 57.4 bits (137), Expect = 2e-07
Identities = 52/177 (29%), Positives = 67/177 (37%), Gaps = 10/177 (5%)
Query: 487 VLVGGTVGLNCPG-QGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
VL G V L C G P P WL DG + R I G L L A
Sbjct: 896 VLEGQPVSLPCIVLAGRPLPERHWL-KDGRPL-----PPGSRHSIRADGSLHLDRALQEH 949
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G Y C+++N + + V P HH G LPC ++G+P +I
Sbjct: 950 AGRYSCVATNTAGSQHRDVELVVQVP--PRIHPTATHHITNEGVPASLPCVASGVPAPTI 1007
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+W N L V GTL I Q + +D G Y C A N G ++SV
Sbjct: 1008 TWT-KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 57.0 bits (136), Expect = 2e-07
Identities = 52/167 (31%), Positives = 73/167 (43%), Gaps = 24/167 (14%)
Query: 521 YVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENG 580
YV E+ +L SG L L D+G Y C +SN A ++R + + Q
Sbjct: 1071 YVWEEYGLL--PSGSLRLAQVQVGDSGHYECTASN--PAGSASHRYVLGVQVPPQVQPGP 1126
Query: 581 IHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNN----GTLRILQVT 636
V +GE LDL C + G P+ +SW S+D VL G++ +
Sbjct: 1127 RVLKVLVGEALDLNCVAEGNPEPQLSW-----------SKDGVVLQGRGPQGSVHFAAIR 1175
Query: 637 PKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDE 683
D G YRC A+N +GVD V+++ P H G E SGL E
Sbjct: 1176 TSDAGRYRCEASNSAGVD----AWEVELRVLEP-PHWGADETSGLLE 1217
Score = 57.0 bits (136), Expect = 2e-07
Identities = 47/164 (28%), Positives = 69/164 (42%), Gaps = 9/164 (5%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG L+C P P V W DG P V + +LE+Q A D
Sbjct: 3044 VRVGDKAVLSCETDALPEPTVTWY-KDGQ----PLVLAQRTQALRGGQRLEIQEAQVSDK 3098
Query: 547 GVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G+Y C SN + T+ +TV V P E + + G L L C +G+P ++
Sbjct: 3099 GLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA--GSPLVLTCDVSGVPAPTV 3156
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
+W + + S+ V G L++ ++ P G Y CVA N
Sbjct: 3157 TW-LKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 3199
Score = 56.6 bits (135), Expect = 3e-07
Identities = 51/179 (28%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
+V+ G L C G P P V W DG V A E G L ++ L ++ A +
Sbjct: 2269 SVVQDGVATLECNATGKPPPTVTW-ERDGQPVGA----ELGLQLQNQGQSLHVERAQAAH 2323
Query: 546 TGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
TG Y C++ N + ++V V P + + + T + L L C + GIP +
Sbjct: 2324 TGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPA 2383
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
I W V D +L G L++ Q +D G Y C+A+N +G F V V
Sbjct: 2384 IRWFRGEEPV--SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 2440
Score = 56.2 bits (134), Expect = 4e-07
Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 8/178 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T + + L C G P P + W + P + L+ L++ D
Sbjct: 2363 TAALHSPLTLLCEAMGIPPPAIRWFRGE-----EPVSPGEDTYLLAGGWMLKMTQTQEQD 2417
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
+G+Y C++SN + + V+ P ++ V G+T L C+ TG P +
Sbjct: 2418 SGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 2477
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTL-RILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+W G + + + +G L ++LQ G+Y C+AAN G FQ+SV
Sbjct: 2478 TWFKDGRPLARGDAHH--ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 2533
Score = 53.5 bits (127), Expect = 3e-06
Identities = 41/181 (22%), Positives = 78/181 (43%), Gaps = 8/181 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T ++ +V L C P P V W +A + E+ L+ + L+L A D
Sbjct: 2948 TAILNSSVSLPCDVHAHPNPEVTWY----KDSQALSLGEEV-FLLPGTHTLQLGRARLSD 3002
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI--GETLDLPCHSTGIPDA 603
+G+Y C + N D +++V+ P G V + G+ L C + +P+
Sbjct: 3003 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP 3062
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
+++W G ++ + R + + L I + D+G Y C +N +G F ++V+
Sbjct: 3063 TVTWYKDGQPLVL-AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 3121
Query: 664 M 664
+
Sbjct: 3122 V 3122
Score = 53.5 bits (127), Expect = 3e-06
Identities = 46/171 (26%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
+ ++ +G + L C +G PTP + W + D VSE D L+
Sbjct: 4137 DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQ-----DGGSTLQRAAVSR 4189
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVF-IGETLDLPCHSTGIPD 602
D+G Y C + N + V E V Q + V +G ++ L C G P
Sbjct: 4190 EDSGTYVCWAENRVGRTQAVSFVHVKEAPV--LQGEAFSYLVEPVGGSIQLDCVVRGDPV 4247
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
I W+ G + + S + L NG+L I + D G Y+C+A N GV
Sbjct: 4248 PDIHWIKDG--LPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGV 4296
Score = 52.8 bits (125), Expect = 5e-06
Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 10/174 (5%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G L C +G P P++ W K P +G+ I SG+L ++ + D G Y
Sbjct: 4052 GSHAFLPCKARGSPEPNITW-----DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTY 4106
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C + N +T++ ++ + ++ +G+ L L C + G P I W +
Sbjct: 4107 TCTAENAVGRARRRVHLTIL--VLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 4164
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
V S TL+ V+ +D G Y C A N G + V VK
Sbjct: 4165 NDRPVTEGVSEQD---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 4215
Score = 52.0 bits (123), Expect = 8e-06
Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 10/173 (5%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L C P P + W D P + D ++ L++ + + + G Y C +S
Sbjct: 2770 LYCDTNAIPPPDLTWYRED-----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 2824
Query: 555 NYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGN 612
N D L Y + V+ P ++ +E TV T+ L C + G P +ISW+ N
Sbjct: 2825 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL--QN 2882
Query: 613 NVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKM 664
+ + S +VL +G L++ D Y CVA N +G +F + V++
Sbjct: 2883 GLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQV 2935
Score = 49.7 bits (117), Expect = 4e-05
Identities = 49/174 (28%), Positives = 69/174 (39%), Gaps = 21/174 (12%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG L C G P P V W + AP S SGKL + A D
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--------SSGKLRIPAAQERDA 760
Query: 547 GVYHCISSNY--DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C + N D + + + L E ++ TV +G + L C +TG P +
Sbjct: 761 GTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD----VTVELGRSALLACRATGRPPPT 816
Query: 605 ISWVIPGNNVL------YQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
++W L + SR ++ ++G L V P+DQ Y C A N G
Sbjct: 817 VTWRRGDGQPLGLRLGAGRGSRSRQP-DSGVLFFESVAPEDQAPYVCEARNVFG 869
Score = 49.7 bits (117), Expect = 4e-05
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 22/186 (11%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L C G P P + W +G V ++ + G+L + A D G Y CI+
Sbjct: 3967 LPCEASGIPRPTITWQ-KEGLNVATGVSTQ-----VLPGGQLRIAHASPEDAGNYLCIAK 4020
Query: 555 NYDDADILTYRITVVEPLVEAYQENGIHH-TVFIGETLDLPCHSTGIPDASISWVIPGNN 613
N + + R+ V P V ENG+ + G LPC + G P+ +I+W G
Sbjct: 4021 NSAGSAMGKTRLVVQVPPV---IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP 4077
Query: 614 VLYQSSRDKK--VLNNGTLRILQVTPKDQGYYRCVAANPSG-------VDFLIFQVSVKM 664
V S + K + +G L + + +D G Y C A N G + L+ V +
Sbjct: 4078 V---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL 4134
Query: 665 KGQRPL 670
G R L
Sbjct: 4135 PGDRSL 4140
Score = 48.1 bits (113), Expect = 1e-04
Identities = 49/178 (27%), Positives = 74/178 (41%), Gaps = 27/178 (15%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD--- 542
TV G T L+C G+ ++ W+ D R+L +G++ Q+AD
Sbjct: 527 TVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPASTGRVA-QLADLSL 572
Query: 543 ------SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH 596
D G Y C++SN + + + V E + + H + G + + C
Sbjct: 573 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCS 630
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
++G P ISW + L + SR V GTL I V P+D G Y C A N G D
Sbjct: 631 ASGYPTPHISWSRE-SQALQEDSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 686
Score = 47.8 bits (112), Expect = 1e-04
Identities = 42/179 (23%), Positives = 73/179 (40%), Gaps = 19/179 (10%)
Query: 498 PGQGDPTPHVDWLLADGSKVRAPYVS---EDGRILIDKSG---------KLELQMADSFD 545
P DP H W G+ + P V G + + +G L+++ D D
Sbjct: 1804 PAACDPPVHRGW----GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 1859
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G+Y C ++N + V+ P + ++ V ++ L C ++G+P +
Sbjct: 1860 EGIYTCAATNLAGESKREVALKVLVP--PNIEPGPVNKAVLENASVTLECLASGVPPPDV 1917
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKM 664
SW G+ + ++ LRI Q D G YRCVA+N +G L + + V +
Sbjct: 1918 SW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 1975
Score = 46.2 bits (108), Expect = 4e-04
Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 9/188 (4%)
Query: 482 KLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMA 541
+L +V+ +V L C P P + W K P G L L++ A
Sbjct: 2077 ELNVSVVANESVALECQSHAMPPPVLSWW-----KDGRPLEPRPGVHLSADKALLQVDRA 2131
Query: 542 DSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
D +D G Y C + N Y + V V P+ + + + TV G L C G+
Sbjct: 2132 DVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL--TVREGHPTSLSCECRGV 2189
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRIL-QVTPKDQGYYRCVAANPSGVDFLIFQ 659
P ISW G + + + + V G L L Q +G Y C +N G Q
Sbjct: 2190 PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 2249
Query: 660 VSVKMKGQ 667
+ V + Q
Sbjct: 2250 LEVHVPPQ 2257
Score = 45.8 bits (107), Expect = 6e-04
Identities = 49/185 (26%), Positives = 77/185 (41%), Gaps = 19/185 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDW------LLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
TV G L+C +G P P + W L +G+ ++ +VS GR+L L
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQ--HVSAVGRLLY-------LG 2223
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHST 598
A G Y C SN ++ V V P + +E +V L C++T
Sbjct: 2224 QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT 2283
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLI 657
G P +++W G V + ++ N G +L + + G Y CVA N +G
Sbjct: 2284 GKPPPTVTWERDGQPV--GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK 2341
Query: 658 FQVSV 662
F++SV
Sbjct: 2342 FELSV 2346
Score = 44.3 bits (103), Expect = 0.002
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 6/70 (8%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV G V L C G+PTP ++WL A G +RA S R L D G L L+ ++ D
Sbjct: 4319 TVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRA---SRRLRTLPD--GSLWLENVETGD 4372
Query: 546 TGVYHCISSN 555
G Y C++ N
Sbjct: 4373 AGTYDCVAHN 4382
Score = 43.1 bits (100), Expect = 0.004
Identities = 52/233 (22%), Positives = 88/233 (37%), Gaps = 25/233 (10%)
Query: 435 SLQLNRTAT----TFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVG 490
SLQL T+S + + + +A+ M P + D+ E ++ G
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIE------DSGQPTELSLTPG 3510
Query: 491 GTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYH 550
+ L C QG P P++ W + R S R+L + D G+Y
Sbjct: 3511 APMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR------------DAGLYT 3558
Query: 551 CISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGE-TLDLPCHSTGIPDASISWVI 609
C++ + A ++R+ V P G V + L L C P I+W
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAP-PNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 3617
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
G VL + + + L++ ++ D G Y C A N +G + F+V +
Sbjct: 3618 DG-IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 3669
Score = 42.0 bits (97), Expect = 0.008
Identities = 43/194 (22%), Positives = 76/194 (39%), Gaps = 28/194 (14%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKL-ELQMADSFDTG 547
V T+ L C P P + W DG V + R+ + G+L ++Q D+G
Sbjct: 2653 VNSTLTLECESWAVPPPTIRWY-KDGQPV-----TPSSRLQVLGEGRLLQIQPTQVSDSG 2706
Query: 548 VYHCISSNYDDADILTYRITVVEPLV----------------EAYQENGI--HHTVFIGE 589
Y C+++N D + + + P + E G+ + +
Sbjct: 2707 RYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENN 2766
Query: 590 TLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAA 648
L C + IP ++W + + + VL G L+I V ++ G Y C A+
Sbjct: 2767 PAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 2824
Query: 649 NPSGVDFLIFQVSV 662
N G D+L +++ V
Sbjct: 2825 NEVGEDWLHYELLV 2838
Score = 37.0 bits (84), Expect = 0.26
Identities = 44/169 (26%), Positives = 62/169 (36%), Gaps = 4/169 (2%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDG-RILIDKSGKLELQMADSF 544
TV +G + L C G P P V W DG + + G R SG L +
Sbjct: 796 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPE 855
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC-HSTGIPDA 603
D Y C + N R+ V + V G+ + LPC G P
Sbjct: 856 DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP 915
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
W+ G L SR + +G+L + + + G Y CVA N +G
Sbjct: 916 ERHWLKDG-RPLPPGSR-HSIRADGSLHLDRALQEHAGRYSCVATNTAG 962
Score = 34.7 bits (78), Expect = 1.3
Identities = 42/179 (23%), Positives = 64/179 (35%), Gaps = 18/179 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLL--ADGSKVRAPYVSEDGRIL------IDKSGKLE 537
T +VG + L C G P P + WL ++ V+ G L +D SG
Sbjct: 1700 TTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFA 1759
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH- 596
Q + T S + + + V+E + Y HH+ F D P H
Sbjct: 1760 CQATNEAGTAGAEVEVSVHGE-----WAPGVLEVPIGQYHWGXEHHSSF-PAACDPPVHR 1813
Query: 597 ---STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ P W PG+ + L+I +V +D+G Y C A N +G
Sbjct: 1814 GWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 1872
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 299 bits (766), Expect = 2e-80
Identities = 279/994 (28%), Positives = 421/994 (42%), Gaps = 101/994 (10%)
Query: 1648 PRI-VGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR--VPSGLDLSKRKQNSRVQVLP 1704
PRI G A + + L CEA G P P + W + P G D+ + L
Sbjct: 1934 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF----YLD 1989
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHS--GST 1762
G+L ++ + D G Y C A N G D T++V+ PP I + T+ S G
Sbjct: 1990 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL-VPPTIKQGADGSGTLVSRPGEL 2048
Query: 1763 VELKCRAEGRPSPTVTWI-------LANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR 1815
V + C G P V+W+ L+ +T++ S TL + + + D
Sbjct: 2049 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH-----------TLRISKVQLADA 2097
Query: 1816 GFYKCVASNPGGQDSLLVKIQVIAAPPVI--LEQRRQVIVGTWGESLKLPCTAKGTPQPS 1873
G + CVA++P G +QV PPV+ +E + V+V G ++LPC A+G P P
Sbjct: 2098 GIFTCVAASPAGVADRNFTLQV-QVPPVLEPVEFQNDVVV-VRGSLVELPCEARGVPLPL 2155
Query: 1874 VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
V W + DG +PL + L +L + + + D GTY C+A S G RR LT
Sbjct: 2156 VSW-MKDG---EPLLSQS----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2207
Query: 1934 MEERVTSPRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGS 1991
+ E P IE + Q TE++ G + L C A G P+P I W H+ G
Sbjct: 2208 VME---PPHIEDSGQP-TELSLTPGAPMELLCDAQGTPQPNITW-----------HKDGQ 2252
Query: 1992 WIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVL 2051
+ N S + +D+G+Y C+A + G V ++ P + + L
Sbjct: 2253 ALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 2312
Query: 2052 HGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGV 2111
++C P P+I+W DG + +Q D R L +
Sbjct: 2313 APGQLVLECSVEAEPAPKITWH-RDGIV----LQEDAHTQFPER-----GRFLQLQALST 2362
Query: 2112 AEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKP 2171
A+ GDY+C A+N G + + + T P IR S + TA+L C+ G P P
Sbjct: 2363 ADSGDYSCTARNAAGSTSVAFRVEIHT-VPTIR-SGPPAVNVSVNQTALLPCQADGVPAP 2420
Query: 2172 KIFWLLPSNDMISFS--IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLD 2229
+ W D + R+ GSL I V D+G Y+C+A N +G D + L
Sbjct: 2421 LVSW---RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR 2477
Query: 2230 VVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
V+ +PP I +N T+ H+ C A G+P P V+W D L
Sbjct: 2478 VL-EPPAIAPSPSNLTL-----TAHTPALLPCEASGSPKPLVVW-WKDGQKLDFRLQQGA 2530
Query: 2290 ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVA 2349
+ + L + DSA F CV NE GE+ + Q+ V PT + + V
Sbjct: 2531 YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIADDQTDFTVT 2587
Query: 2350 QLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKY 2409
+ L C G P P + W + G + Y ++ +G+ I + AG+Y
Sbjct: 2588 MMA-PVVLTCHSTGIPAPTVSW---SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2643
Query: 2410 RCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP 2469
C+ARN G K V L + PV+ P V+ ++ E + L C + GIP+P I W
Sbjct: 2644 TCSARNSAGVAHKHVFLTVQASPVVKP-LPSVVRAVAEEEVLLPCEASGIPRPTITWQKE 2702
Query: 2470 SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
V + G L I A+ D GNY+C A+NS G + ++V PP
Sbjct: 2703 GLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR-LVVQVPPV 2757
Query: 2530 ITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT 2589
I N P T AF L C A G P+P ITW+ D +S A G + G
Sbjct: 2758 IENGLPDLSTTEGSHAF-LPCKARGSPEPNITWD-KDGQPVSGA-----EGKFTIQPSGE 2810
Query: 2590 LVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L+++N + D+G Y CTA+N +G ++ ++
Sbjct: 2811 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL 2844
Score = 299 bits (766), Expect = 2e-80
Identities = 257/994 (25%), Positives = 428/994 (43%), Gaps = 103/994 (10%)
Query: 1644 IFEKPRIV-GGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV 1702
+ E P I G+ ++ + L C+A G P P I W + G L++ + NSR
Sbjct: 2208 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK--DGQALTRLENNSR--- 2262
Query: 1703 LPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
+ + + ++D G Y C A + G + V + P + R + + +
Sbjct: 2263 ------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ 2316
Query: 1763 VELKCRAEGRPSPTVTW----ILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFY 1818
+ L+C E P+P +TW I+ + ++ + R L L LS D G Y
Sbjct: 2317 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGR--------FLQLQALSTADSGDY 2368
Query: 1819 KCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVL 1878
C A N G S+ ++++ P + + + ++ LPC A G P P V W
Sbjct: 2369 SCTARNAAGSTSVAFRVEIHTVPTI--RSGPPAVNVSVNQTALLPCQADGVPAPLVSW-- 2424
Query: 1879 SDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
+ PL + + + G+L I+ + + D G Y C+A++S GS+R+ + RV
Sbjct: 2425 --RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQ----GRDLRV 2478
Query: 1939 TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN 1998
P A S + LL C A+G PKP ++W + + D + + G++ + P+
Sbjct: 2479 LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKL-DFRLQQGAY-RLLPS 2536
Query: 1999 GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQV 2058
+L + + +DS + CV N++G+ L V++ + P D + F ++ +
Sbjct: 2537 NALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMM--APVVL 2594
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
C ++G P P +SWS + G R Y + +G L + G YT
Sbjct: 2595 TCHSTGIPAPTVSWSKAGAQL----------GARGSGYRVSPSGALEIGQALPIHAGRYT 2644
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A+N+ G V LTV A+P ++ + + A + +L CE +G P+P I W
Sbjct: 2645 CSARNSAGVAHKHVFLTV-QASPVVKPLPSVVRAV-AEEEVLLPCEASGIPRPTITWQKE 2702
Query: 2179 SNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI- 2237
++ + + G L I D+G Y+C+A+N +G +L VV PP+I
Sbjct: 2703 GLNVATGVSTQVL--PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL-VVQVPPVIE 2759
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGS--RITVHKN 2295
NGL T S C+A G+P P + W P G+ + T+ +
Sbjct: 2760 NGLPDLSTT------EGSHAFLPCKARGSPEPNITWDKDGQ-----PVSGAEGKFTIQPS 2808
Query: 2296 GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKST 2355
G L ++N+ D+ + C A N G + V L +L + P F ++ + +LG
Sbjct: 2809 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSL-RLGDRL 2864
Query: 2356 ALNCSVDGNPPPEIIWILPN-----GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYR 2410
L C+ G+P P I W + + G +G + Q S RED+G Y
Sbjct: 2865 WLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS----------REDSGTYV 2914
Query: 2411 CAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPS 2470
C A N+VG + + + + + PV+ A + G S+ L CV G P P+I W
Sbjct: 2915 CWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW---- 2970
Query: 2471 GYVVDRPQINGKYILHD--NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPP 2528
+ D + G ++ H NG+L I+ D G Y C A+N +G V +++ + P
Sbjct: 2971 --IKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP- 3027
Query: 2529 RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQG 2588
+ P+ + R+G L C A G P P I W L R + G
Sbjct: 3028 -VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-------LQAGQPLRASRRLRTLPDG 3079
Query: 2589 TLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+L ++N +T D+G Y C A N LGS A ++ V
Sbjct: 3080 SLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3113
Score = 278 bits (711), Expect = 5e-74
Identities = 261/962 (27%), Positives = 387/962 (40%), Gaps = 91/962 (9%)
Query: 1670 CEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG---TLSIQRVEIQDRGQYLCSAS 1726
C G+P + W + L LS+R L +G TL I +V++ D G + C A+
Sbjct: 2053 CPVRGSPPIHVSWLKDGLPLPLSQR-------TLLHGSGHTLRISKVQLADAGIFTCVAA 2105
Query: 1727 NLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV 1786
+ G + TL V P ++ V GS VEL C A G P P V+W+ + +
Sbjct: 2106 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 2165
Query: 1787 VSES-SQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVIL 1845
+S+S QG +L L + D G Y CVA + G+ ++ V+ P +
Sbjct: 2166 LSQSLEQGP---------SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED 2216
Query: 1846 EQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIR 1905
+ + T G ++L C A+GTPQP++ W DG + L+ N + R
Sbjct: 2217 SGQPTELSLTPGAPMELLCDAQGTPQPNITWH-KDGQALTRLE----------NNSRATR 2265
Query: 1906 NLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGD-KLLLNCS 1964
L D G Y C+A S G+ + + ++ P I R V +L+L CS
Sbjct: 2266 VLRVRDAGLYTCLAESPAGAIEKSFRVRVQ---APPNIVGPRGPRFVVGLAPGQLVLECS 2322
Query: 1965 ATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIG--SVTEKDSGVYLCVARNKM 2022
EP P+I W + + H +P F+ +++ DSG Y C ARN
Sbjct: 2323 VEAEPAPKITWHRDGIVLQEDAHTQ------FPERGRFLQLQALSTADSGDYSCTARNAA 2376
Query: 2023 GDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINN 2082
G + V + P V + + C+A G P P +SW +
Sbjct: 2377 GSTSVAFRVEIHTVPTIRSGPPAVNVSV--NQTALLPCQADGVPAPLVSWR-------KD 2427
Query: 2083 AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPR 2142
+ D R+ R+ + G+L V + G Y C A N+ G D L V+ P
Sbjct: 2428 RVPLDP---RSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-PA 2483
Query: 2143 IRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDR--YTFHANGSLTI 2200
I S +N + A A+L CE +G PKP + W + F + + Y + +L +
Sbjct: 2484 IAPS-PSNLTLTAHTPALLPCEASGSPKPLVVWW-KDGQKLDFRLQQGAYRLLPSNALLL 2541
Query: 2201 NKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFD 2260
DS ++ CV N G+ ++Y++ V PP I T+ TV V
Sbjct: 2542 TAPGPQDSAQFECVVSNEVGEAHRLYQV-TVHVPPTIADDQTDFTVTMMAPVV-----LT 2595
Query: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG 2320
C + G P+P V W GS V +G LEI + + C ARN G
Sbjct: 2596 CHSTGIPAPTVSW---SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG 2652
Query: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS 2380
V V ++ P + A + L C G P P I W G +
Sbjct: 2653 ----VAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW-QKEGLNVA 2707
Query: 2381 NGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPG 2440
G + + G I+ + EDAG Y C A+N G L + PVI P
Sbjct: 2708 TGVSTQ---VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD 2764
Query: 2441 TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD 2500
+ G L C + G P+PNI W G V + GK+ + +G L++K D
Sbjct: 2765 -LSTTEGSHAFLPCKARGSPEPNITWDK-DGQPVSGAE--GKFTIQPSGELLVKNLEGQD 2820
Query: 2501 RGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEI 2560
G Y C A+N+VG V + I+ P T RS+ R G L C A G P P I
Sbjct: 2821 AGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL--RLGDRLWLRCAARGSPTPRI 2878
Query: 2561 TWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYI 2620
W + D + S E+ GS TL DSG Y C A+N +G A +++
Sbjct: 2879 GWTVNDRPVTEGVS-EQDGGS-------TLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 2930
Query: 2621 QV 2622
V
Sbjct: 2931 HV 2932
Score = 276 bits (707), Expect = 1e-73
Identities = 255/929 (27%), Positives = 396/929 (42%), Gaps = 81/929 (8%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L I++V+++D G Y C+A+NL G V L V+ PP I E V ++V L+C
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNI-EPGPVNKAVLENASVTLEC 625
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG-TLVLHNLSIYDRGFYKCVASNPG 1826
A G P P V+W +Q V S V+VDG L + + D G Y+CVASN
Sbjct: 626 LASGVPPPDVSWFKGHQPVSSWMG-----VTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 680
Query: 1827 GQDSLLVKIQVIAAPPVILEQR--RQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G L ++V P + L V+V T ++L C A G P P++ W L DG V
Sbjct: 681 GSTELRYGLRVNVPPRITLPPSLPGPVLVNT---PVRLTCNATGAPSPTLMW-LKDGNPV 736
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
P ++F L + + +SD G Y C+A S+ G +R+ V+L +V P
Sbjct: 737 SPAGTPGLQVFP-GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL----QVHMPPSI 791
Query: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF-I 2003
+ V + + L C + P P + W + + + R G +H+ + +L +
Sbjct: 792 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL---EPRPG--VHLSADKALLQV 846
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKAS 2063
D+G Y C A N+ G ++++ + P ++ V G ++ C+
Sbjct: 847 DRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPV-FPLRESHTLTVREGHPTRLSCECR 905
Query: 2064 GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQN 2123
G P P+ISW DG + + +G ++ LY + +A+EG YTC N
Sbjct: 906 GVPFPKISWR-KDG----QPLPGEGAG---LQHVSAVGRLLYLGQAQLAQEGTYTCECSN 957
Query: 2124 TLGKD----EMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPS 2179
+G +++VH+ A PR T + A L+C TG P P + W
Sbjct: 958 VVGNSSQDLQLEVHVPPQIAGPR---EPPTQVSVVQDGVATLECNATGKPPPTVTW-ERD 1013
Query: 2180 NDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLING 2239
+ + + SL + + + +G Y CVA N +G + ++L V+ P LI
Sbjct: 1014 GQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD 1073
Query: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG--T 2297
L + TA HS C A G P P + W + P T G
Sbjct: 1074 L---DPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEE-----PVSPGEDTYLLAGGWM 1125
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQL-GKSTA 2356
L++ + DS + C+A NE GE+ +EVL P+ N E+++ L G++
Sbjct: 1126 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV---PPSIENEDLEEVIKVLDGQTAH 1182
Query: 2357 LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI-ISKTTREDAGKYRCAARN 2415
L C+V G+P P++ W +G + G + I+ +G + + + AG Y C A N
Sbjct: 1183 LMCNVTGHPQPKLTW-FKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAAN 1238
Query: 2416 KVGYIEKLVILEIGQKPVILTYAPGT----VKGISGESLSLHCVSDGIPKPNIKWTMPSG 2471
VG K L + P IL A + V +SL C + P PNI W M G
Sbjct: 1239 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MKDG 1297
Query: 2472 YVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRIT 2531
+ + +L L I A D G Y C N +G + V ++ PP I+
Sbjct: 1298 APFEASR--NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPPSIS 1354
Query: 2532 NRPP------RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
P + + T+ + L C + VP P I W D ++ +S+ + G +L
Sbjct: 1355 KDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-YKDGQPVTPSSRLQVLGEGRL- 1412
Query: 2586 LQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
L IQ Q SDSG Y C A N G D
Sbjct: 1413 ----LQIQPTQVSDSGRYLCVATNVAGED 1437
Score = 269 bits (688), Expect = 2e-71
Identities = 255/1005 (25%), Positives = 404/1005 (40%), Gaps = 104/1005 (10%)
Query: 1648 PRIVGGKAASFTIPANSD--AFLPCEAVGNPLPTIHWTR--VPSGLDLSKRKQNSRVQVL 1703
P+I G + + D A L C A G P PT+ W R P G +L + QN
Sbjct: 974 PQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ----- 1028
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRI--LERRTKEITVHSGS 1761
+L ++R + G+Y C A NL G LSV+ P I L+ T IT S
Sbjct: 1029 -GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN-ITAALHS 1086
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
+ L C A G P P + W + V S G ++ L + D G Y C+
Sbjct: 1087 PLTLLCEAMGIPPPAIRWFRGEEPV----SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCL 1142
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
ASN G+ ++V+ P + E +VI G++ L C G PQP + W DG
Sbjct: 1143 ASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW-FKDG 1201
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
+PL ++ L + S G Y CIA ++ G + + L++ + +P
Sbjct: 1202 ---RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV---LLAP 1255
Query: 1942 RI----EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
I E ++ + V + + L C A P P I W ++ I + P
Sbjct: 1256 TILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRN-----IQLLP 1310
Query: 1998 -NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP--------AKIDHKQYFRK 2048
L I + ++D+G Y CV N++G+ + HV + + P A++ K+ K
Sbjct: 1311 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTK 1370
Query: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
++C++ P P I W DG + + +R L L
Sbjct: 1371 V---NSTLTLECESWAVPPPTIRW-YKDGQPVTPS---------SRLQVLGEGRLLQIQP 1417
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHL------------------TVITAAPRIRQSNKTN 2150
V++ G Y C A N G+D+ ++ +++ R
Sbjct: 1418 TQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEY 1477
Query: 2151 KRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGE 2210
+ I + A L C+ P P + W + +S + L I V+ ++G
Sbjct: 1478 REIVENNPAYLYCDTNAIPPPDLTW-YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR 1536
Query: 2211 YVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
Y C A N G+D Y+L +V PP+I G T V + T S C A G P P
Sbjct: 1537 YSCKASNEVGEDWLHYEL-LVLTPPVILG-DTEELVEEVTVNASSTVSLQCPALGNPVPT 1594
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNG-TLEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
+ W+ F +P R+ V ++G L++ ++D+A ++CVA N+ G + +L
Sbjct: 1595 ISWLQNGLPFSPSP----RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA---EKLF 1647
Query: 2330 VLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL 2389
L + P E++ A L S +L C V +P PE+ W + S G + +L
Sbjct: 1648 TLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW-YKDSQALSLGEE--VFL 1704
Query: 2390 IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGI---S 2446
+ + + + D+G Y C A N G +KLV L + P G +
Sbjct: 1705 LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV 1764
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRGNY 2504
G+ L C +D +P+P + W Y +P + + L L I+EA D+G Y
Sbjct: 1765 GDKAVLSCETDALPEPTVTW-----YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY 1819
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
CK N G + T + V PP N ++ G+ L C GVP P +TW
Sbjct: 1820 SCKVSNVAGEAVRTF-TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK 1878
Query: 2565 PDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
+ S+A HG + G L + Q + +G Y C A+N
Sbjct: 1879 DRMPVESSA----VHG--VVSRGGRLQLSRLQPAQAGTYTCVAEN 1917
Score = 260 bits (664), Expect = 1e-68
Identities = 254/1006 (25%), Positives = 410/1006 (40%), Gaps = 94/1006 (9%)
Query: 1653 GKAASFTIPANSDAFLPCEAVGNPLPTIHWTR------VPSGL-----DLSKRKQNSRVQ 1701
G+ A+ + A L C+A G P+P I W + VP G DL +
Sbjct: 23 GRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 82
Query: 1702 VLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGS 1761
+ +L R++ D G Y C A N GT L V++ P + +E+ +G+
Sbjct: 83 LDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGA 142
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV-LHNLSIYDRGFYKC 1820
VEL+C G P+P V W Q V+ G V DG ++ + + D G Y+C
Sbjct: 143 DVELQCWTSGVPTPQVEWTKDRQPVLP----GGPHLQVQEDGQVLRITGSHVGDEGRYQC 198
Query: 1821 VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
VA +P GQ + +++V A P + + ++L C A+G P P++ W D
Sbjct: 199 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW-FKD 257
Query: 1881 GTEVKPLQFTNSKLFLFSNGT-LYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
G L T++K+ G L + SSD G Y C A+++ G+ + L +
Sbjct: 258 GA----LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV---YV 310
Query: 1940 SPRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
P IE A + V G + L C A G P P + W V + +
Sbjct: 311 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES-----RLET 365
Query: 1998 NGSLF-IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDF 2056
+GS+ + S E SG+Y CVA + G+ ++ V +++ P + + + + G+
Sbjct: 366 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 425
Query: 2057 QVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGD 2116
++ C+ASGSPVP I W L +G + T TL+ + V + G
Sbjct: 426 ELPCQASGSPVPTIQW-LQNGRPAEELAGVQVASQGT---------TLHIDHVELDHSGL 475
Query: 2117 YTCYAQNTLGKDEMKVHLTV-------ITAAP--RIRQSNKTNKRIKAGDTAVLDCEVTG 2167
+ C A N G +V ++V + P + + + A +
Sbjct: 476 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 535
Query: 2168 DPKPKI---------FWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNP 2218
PKP + W P+ +++S+ L I KV L D G Y C A N
Sbjct: 536 HPKPPLVEGWCSPGSLWGEPTGIPVAYSLP-------PPLQIEKVDLRDEGIYTCAATNL 588
Query: 2219 SGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDN 2278
+G+ + L V+ PP I N+ V++ +V +C A G P P+V W
Sbjct: 589 AGESKREVALKVL-VPPNIEPGPVNKAVLENASVT-----LECLASGVPPPDVSWFKGHQ 642
Query: 2279 IFLTAPYYGSRITVHKNG-TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRP 2337
+ + G +TV +G L I +LSD+ + CVA N G + L L V P
Sbjct: 643 --PVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV---PP 695
Query: 2338 TFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI 2397
P + + L C+ G P P ++W L +G S +
Sbjct: 696 RITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNPVSPAGTPGLQVFPGGRVLT 754
Query: 2398 ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSD 2457
++ D+G+Y C A + VG + V+L++ P IL V ++ ES++L C S
Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG-EELNVSVVANESVALECQSH 813
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
+P P + W + RP G ++ D L + A +D G+Y C+A N GH+
Sbjct: 814 AMPPPVLSWWKDGRPLEPRP---GVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEK 870
Query: 2518 TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKER 2577
+ V P R ++ R G +L C GVP P+I+W L +
Sbjct: 871 HYN-LNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGA--- 926
Query: 2578 THGSEQLHLQGTLV-IQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G + + G L+ + Q + G Y C N +G+ ++V
Sbjct: 927 --GLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 970
Score = 259 bits (663), Expect = 2e-68
Identities = 254/1022 (24%), Positives = 403/1022 (39%), Gaps = 109/1022 (10%)
Query: 1648 PRIVGG--KAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
P ++G + T +S L CEA+G P P I W R + +L
Sbjct: 1068 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS-----PGEDTYLLAG 1122
Query: 1706 G-TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKE-ITVHSGSTV 1763
G L + + + QD G Y C ASN G + ++ V+ PP I +E I V G T
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL-VPPSIENEDLEEVIKVLDGQTA 1181
Query: 1764 ELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV-LHNLSIYDRGFYKCVA 1822
L C G P P +TW + + + ++ DG L+ + ++ G Y C+A
Sbjct: 1182 HLMCNVTGHPQPKLTWFKDGRPLARGDAHH-----ISPDGVLLQVLQANLSSAGHYSCIA 1236
Query: 1823 SNPGGQDSLLVKIQVIAAPPVI---LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLS 1879
+N G+ + ++ V+ AP ++ + + + T + L C A P P++ W +
Sbjct: 1237 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MK 1295
Query: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERR----VVMLTME 1935
DG P + + + L L I N D G Y C+ T+ G + V++
Sbjct: 1296 DGA---PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1352
Query: 1936 ERVTSPRIEAASQK-RTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIH 1994
P E ++ +T+VN L L C + P P I W + V S +
Sbjct: 1353 ISKDDPLAEVGVKEVKTKVN--STLTLECESWAVPPPTIRWYKDGQPVTPS-----SRLQ 1405
Query: 1995 VYPNGSLFIGSVTE-KDSGVYLCVARNKMGDDLILMHVSLRLKPA--KI-DHKQYFR--- 2047
V G L T+ DSG YLCVA N G+D +V +++ P K+ D F
Sbjct: 1406 VLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1465
Query: 2048 ------------KQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRR 2095
++++ + C + P P+++W D + + G R +
Sbjct: 1466 REEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQ 1525
Query: 2096 YTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI-- 2153
L V G Y+C A N +G+D + L V+T + + + + +
Sbjct: 1526 IPL----------VRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTV 1575
Query: 2154 KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYV 2212
A T L C G+P P I WL N + R +G L ++ ++ D+ Y+
Sbjct: 1576 NASSTVSLQCPALGNPVPTISWL--QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYM 1633
Query: 2213 CVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVM 2272
CVA N +G K++ L V PP I GL + + TA+ +S C P+PEV
Sbjct: 1634 CVAENQAGSAEKLFTLRV-QVPPRIAGL----DLEQVTAILNSSVSLPCDVHAHPNPEVT 1688
Query: 2273 WIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLE 2332
W H TL++ RLSDS + C A N G +VQL VL
Sbjct: 1689 WYKDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1745
Query: 2333 MLRRPTFRNPFN---EKIVAQLGKSTALNCSVDGNPPPEIIW-------ILPNGTRFSNG 2382
P FR + ++ ++G L+C D P P + W +L T+ G
Sbjct: 1746 P---PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRG 1802
Query: 2383 PQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTV 2442
Q + I + D G Y C N G + L + P TV
Sbjct: 1803 GQRLE----------IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETV 1852
Query: 2443 KGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRG 2502
++G L L C G+P P + W + V+ ++G ++ G L + G
Sbjct: 1853 SQVAGSPLVLTCDVSGVPAPTVTW-LKDRMPVESSAVHG--VVSRGGRLQLSRLQPAQAG 1909
Query: 2503 NYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITW 2562
Y C A+N+ V ++ P ++ R G +L C A G P P++ W
Sbjct: 1910 TYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW 1969
Query: 2563 EMPDHSLLSTASKERTHGSEQLHLQ-GTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQ 2621
+ D S L + +L G+LV++ + SD+G Y C A NP G D +
Sbjct: 1970 -LKDGSPLGQDMGPHL----RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVN 2024
Query: 2622 VI 2623
V+
Sbjct: 2025 VL 2026
Score = 248 bits (632), Expect = 7e-65
Identities = 251/990 (25%), Positives = 392/990 (39%), Gaps = 95/990 (9%)
Query: 1663 NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYL 1722
N+ L C A G P P + W + G V V L I++ ++ D G Y
Sbjct: 618 NASVTLECLASGVPPPDVSWFK---GHQPVSSWMGVTVSV-DGRVLRIEQAQLSDAGSYR 673
Query: 1723 CSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILA 1782
C ASN+ G+ L L V+ PPRI + V + V L C A G PSPT+ W+
Sbjct: 674 CVASNVAGSTELRYGLR-VNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKD 732
Query: 1783 NQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP 1842
V + G + V L L + D G Y CVA + G+D V +QV P
Sbjct: 733 GNPVSPAGTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 790
Query: 1843 VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTL 1902
++ E+ +V ES+ L C + P P + W DG +PL+ L
Sbjct: 791 ILGEELNVSVVA--NESVALECQSHAMPPPVLSW-WKDG---RPLEPRPGVHLSADKALL 844
Query: 1903 YIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLN 1962
+ D G Y C A + G + L + +P V G L+
Sbjct: 845 QVDRADVWDAGHYTCEALNQAGHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTRLS 901
Query: 1963 CSATGEPKPQIMWRLPSKAVVDQQHRVGSWI-HVYPNGS-LFIGSVTEKDSGVYLCVARN 2020
C G P P+I WR + + + G+ + HV G L++G G Y C N
Sbjct: 902 CECRGVPFPKISWRKDGQPLPGE----GAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN 957
Query: 2021 KMGDDLILMHVSLRLKPAKIDHKQ-YFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTM 2079
+G+ + + + + P ++ + V+ ++C A+G P P ++W DG
Sbjct: 958 VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE-RDGQP 1016
Query: 2080 INN--AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVI 2137
+ +Q + G +L+ + A G Y+C A+N G+ E K L+V+
Sbjct: 1017 VGAELGLQLQNQGQ-----------SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL 1065
Query: 2138 TAAPRIRQSNK-TNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
I + TN L CE G P P I W + +S D Y
Sbjct: 1066 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW-FRGEEPVSPGEDTYLLAGGW 1124
Query: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
L + + + DSG Y C+A N +G+ + + ++V+ P + N VIK +
Sbjct: 1125 MLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIK--VLDGQT 1180
Query: 2257 KHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT-LEIRNVRLSDSADFICVA 2315
H C G P P++ W G + +G L++ LS + + C+A
Sbjct: 1181 AHLMCNVTGHPQPKLTWFKDGRPLAR----GDAHHISPDGVLLQVLQANLSSAGHYSCIA 1236
Query: 2316 RNEGGESVLVVQLEVLEMLRRPTF----RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIW 2371
N GE QL V L PT + +E++ + +L C P P I W
Sbjct: 1237 ANAVGEKTKHFQLSV---LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW 1293
Query: 2372 ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG------YIEKLVI 2425
+ +G F ++ Q L ++G I++ +EDAG+Y C N++G ++E L+
Sbjct: 1294 -MKDGAPF-EASRNIQLLPGTHGLQILN-AQKEDAGQYTCVVTNELGEAVKNYHVEVLIP 1350
Query: 2426 LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYIL 2485
I + + VK +L+L C S +P P I+W V ++ +L
Sbjct: 1351 PSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ---VL 1407
Query: 2486 HDNGTLVIKEATAYDRGNYICKAQNSVG------HTLITVPVMI-------VAYPPRITN 2532
+ L I+ D G Y+C A N G + LI VP M A+
Sbjct: 1408 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 1467
Query: 2533 RPPRSIVTRTGAAFQ-----LHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQ 2587
R VT + L+C +P P++TW D L + G E LQ
Sbjct: 1468 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL--------SAGDEVSVLQ 1519
Query: 2588 GTLVIQNP--QTSDSGIYKCTAKNPLGSDY 2615
G V+Q P + ++G Y C A N +G D+
Sbjct: 1520 GGRVLQIPLVRAENAGRYSCKASNEVGEDW 1549
Score = 247 bits (630), Expect = 1e-64
Identities = 219/795 (27%), Positives = 331/795 (41%), Gaps = 78/795 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
P I G A + N A LPC+A G P P + W + LD ++ R ++LP G+
Sbjct: 2391 PTIRSGPPA-VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD----PRSPRFEILPEGS 2445
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L IQ V QD G YLC ASN G+D L V+ P +T H+ + L C
Sbjct: 2446 LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPAL--LPC 2503
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG 1827
A G P P V W Q + QG+ + + + L+L D ++CV SN G
Sbjct: 2504 EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS--NALLLTAPGPQDSAQFECVVSNEVG 2561
Query: 1828 QDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPL 1887
+ L ++ V PP I + + V T + L C + G P P+V W + L
Sbjct: 2562 EAHRLYQVTV-HVPPTIADDQTDFTV-TMMAPVVLTCHSTGIPAPTVSWSKAGAQ----L 2615
Query: 1888 QFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAAS 1947
S + +G L I G Y C A +S G + V LT++ + +
Sbjct: 2616 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVV 2675
Query: 1948 QKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007
+ E +++LL C A+G P+P I W+ V G V P G L I +
Sbjct: 2676 RAVAE----EEVLLPCEASGIPRPTITWQKEGLNVA-----TGVSTQVLPGGQLRIAHAS 2726
Query: 2008 EKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
+D+G YLC+A+N G + + +++ P + G + CKA GSP
Sbjct: 2727 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPP--VIENGLPDLSTTEGSHAFLPCKARGSPE 2784
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P I+W DG ++ A ++T+ +G L + + G YTC A+N +G+
Sbjct: 2785 PNITWD-KDGQPVSGA---------EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR 2834
Query: 2128 DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSI 2187
+VHLT++ + + ++ ++ GD L C G P P+I W + ND +
Sbjct: 2835 ARRRVHLTILVLP--VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV--NDR---PV 2887
Query: 2188 DRYTFHANGSLTINK--VKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRT 2245
+G T+ + V DSG YVC A N G + + V P L ++
Sbjct: 2888 TEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLV 2947
Query: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVH-KNGTLEIRNVR 2304
+++ DC G P P++ WI P GS + +NG+L IR
Sbjct: 2948 EPVGGSIQ-----LDCVVRGDPVPDIHWIKDG-----LPLRGSHLRHQLQNGSLTIRRTE 2997
Query: 2305 LSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGN 2364
D+ + C+A NE G + VV +L + P F+ + V G AL C G
Sbjct: 2998 RDDAGRYQCLAENEMGVAKKVV---ILVLQSAPVFQVEPQDMTVRS-GDDVALRCQATGE 3053
Query: 2365 PPPEIIWILPNGTRFSNGPQSYQYLIAS-------NGSFIISKTTREDAGKYRCAARNKV 2417
P P I W+ Q+ Q L AS +GS + DAG Y C A N +
Sbjct: 3054 PTPTIEWL-----------QAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLL 3102
Query: 2418 GYIEKLVILEIGQKP 2432
G L + +P
Sbjct: 3103 GSATARAFLVVRGEP 3117
Score = 232 bits (591), Expect = 4e-60
Identities = 249/1005 (24%), Positives = 397/1005 (39%), Gaps = 96/1005 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG- 1706
PRI + + N+ L C A G P PT+ W + G +S +QV P G
Sbjct: 695 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DGNPVSP-AGTPGLQVFPGGR 751
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELK 1766
L++ D G+Y C A + G D V L V PP IL ++V + +V L+
Sbjct: 752 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQ-VHMPPSILGEEL-NVSVVANESVALE 809
Query: 1767 CRAEGRPSPTVTWILANQTVVSESS--QGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
C++ P P ++W + + + +A++ VD ++D G Y C A N
Sbjct: 810 CQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVD------RADVWDAGHYTCEALN 863
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G + V AP L + + V G +L C +G P P + W DG
Sbjct: 864 QAGHSEKHYNLNVWVAPVFPLRESHTLTVRE-GHPTRLSCECRGVPFPKISW-RKDG--- 918
Query: 1885 KPLQFTNSKLFLFS--NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
+PL + L S LY+ + GTY C ++ G+ + + L + P+
Sbjct: 919 QPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH---VPPQ 975
Query: 1943 IEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS 2000
I + T+V+ L C+ATG+P P + W + V + +G + S
Sbjct: 976 IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE---LGLQLQ-NQGQS 1031
Query: 2001 LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK--QVLHGKDFQV 2058
L + +G Y CVA N G +S+ + P I LH +
Sbjct: 1032 LHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALH-SPLTL 1090
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
C+A G P P I W + G T Y L L + + G Y+
Sbjct: 1091 LCEAMGIPPPAIRWF--------RGEEPVSPGEDT--YLLAGGWMLKMTQTQEQDSGLYS 1140
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A N G+ + V+ + + ++ G TA L C VTG P+PK+ W
Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1200
Query: 2179 SNDMISFSIDRYTFHANG-SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
+ D + +G L + + L +G Y C+A N G+ TK ++L V+ P ++
Sbjct: 1201 GRPLARG--DAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 1258
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
G + + T ++ C A PSP + W M D AP+ SR GT
Sbjct: 1259 GGAEDSADE-EVTVTVNNPISLICEALAFPSPNITW-MKDG----APFEASRNIQLLPGT 1312
Query: 2298 --LEIRNVRLSDSADFICVARNEGGESVLVVQLEVL---EMLRRPTFRNPFNEKIVAQLG 2352
L+I N + D+ + CV NE GE+V +EVL + + +++ ++
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372
Query: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
+ L C PPP I W +G + P S ++ I T D+G+Y C
Sbjct: 1373 STLTLECESWAVPPPTIRW-YKDGQPVT--PSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1429
Query: 2413 ARNKVGYIEKLVILEIGQKPV------------ILTYAPGTVKGIS-------GESLSLH 2453
A N G ++ + I P+ IL+ G++ L+
Sbjct: 1430 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489
Query: 2454 CVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRGNYICKAQNS 2511
C ++ IP P++ W Y D+P G +L L I A + G Y CKA N
Sbjct: 1490 CDTNAIPPPDLTW-----YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE 1544
Query: 2512 VGHTLITVPVMIVAYPPRI---TNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHS 2568
VG + ++++ PP I T + + L C ALG P P I+W + +
Sbjct: 1545 VGEDWLHYELLVLT-PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGL 1602
Query: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
S + + + Q+ L + + +D+ Y C A+N GS
Sbjct: 1603 PFSPSPRLQVLEDGQV-----LQVSTAEVADAASYMCVAENQAGS 1642
Score = 207 bits (528), Expect = 8e-53
Identities = 246/1011 (24%), Positives = 382/1011 (37%), Gaps = 119/1011 (11%)
Query: 1644 IFEKPRIVGGKAASFTIPA--NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQ 1701
++ P I G + + A L C A G+P PT+ W GL +++ + SR++
Sbjct: 308 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH--EGLPVAESNE-SRLE 364
Query: 1702 VLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGS 1761
L ++ G Y C AS+ G L ++ V P ++ ++T G
Sbjct: 365 T-DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 423
Query: 1762 TVELKCRAEGRPSPTVTWILANQTV-----VSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
+EL C+A G P PT+ W+ + V +SQG+ TL + ++ + G
Sbjct: 424 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT---------TLHIDHVELDHSG 474
Query: 1817 FYKCVASNPGGQDSLLVKIQVIA--APPVILEQRRQVIVGT--WGESLKLPCTAKGTPQP 1872
+ C A+N G V++ V AP V+ +V +G WG A P
Sbjct: 475 LFACQATNEAGTAGAEVEVSVHGEWAPGVL-----EVPIGQYHWGXEHHSSFPAACDPPV 529
Query: 1873 SVYWVLSDGTEVKP--LQFTNSKLFLFSNGT-----------LYIRNLASSDRGTYECIA 1919
W G KP ++ S L+ T L I + D G Y C A
Sbjct: 530 HRGW----GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAA 585
Query: 1920 TSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPS 1979
T+ G +R V L + + P IE + + + L C A+G P P + W
Sbjct: 586 TNLAGESKREVALKV---LVPPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSW---- 637
Query: 1980 KAVVDQQHRVGSWIHV---YPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLK 2036
V SW+ V L I D+G Y CVA N G + + + +
Sbjct: 638 ---FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV- 693
Query: 2037 PAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRY 2096
P +I VL ++ C A+G+P P + W L DG ++ A T
Sbjct: 694 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNPVSPA--------GTPGL 744
Query: 2097 TLFNNG-TLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKA 2155
+F G L ++ G Y+C A + +G+D V L V P + N + A
Sbjct: 745 QVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILGEELNVSVVA 802
Query: 2156 GDTAVLDCEVTGDPKPKIFWL-----LPSNDMISFSIDRYTFHANGSLTINKVKLLDSGE 2210
++ L+C+ P P + W L + S D+ L +++ + D+G
Sbjct: 803 NESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK------ALLQVDRADVWDAGH 856
Query: 2211 YVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
Y C A N +G K Y L+V P ++ R T C G P P+
Sbjct: 857 YTCEALNQAGHSEKHYNLNVWVAP-----VFPLRESHTLTVREGHPTRLSCECRGVPFPK 911
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
+ W D L G + L + +L+ + C N G S +QLEV
Sbjct: 912 ISW-RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 970
Query: 2331 LEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLI 2390
+ R P + V Q G +T L C+ G PPP + W G + L
Sbjct: 971 HVPPQIAGPREPPTQVSVVQDGVAT-LECNATGKPPPTVTW---ERDGQPVGAELGLQLQ 1026
Query: 2391 ASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESL 2450
S + + G+Y C A N G E+ L + P ++ G + ++ +
Sbjct: 1027 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELI----GDLDPLTNITA 1082
Query: 2451 SLH------CVSDGIPKPNIKWTMPSGYVVDRPQINGK--YILHDNGTLVIKEATAYDRG 2502
+LH C + GIP P I+W + + P G+ Y+L L + + D G
Sbjct: 1083 ALHSPLTLLCEAMGIPPPAIRW-----FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 1137
Query: 2503 NYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIV-TRTGAAFQLHCVALGVPKPEIT 2561
Y C A N G V ++ PP I N ++ G L C G P+P++T
Sbjct: 1138 LYSCLASNEAGEARRNFSVEVLV-PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT 1196
Query: 2562 WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
W L A + H S L L + S +G Y C A N +G
Sbjct: 1197 WFKDGRPL---ARGDAHHISPDGVL---LQVLQANLSSAGHYSCIAANAVG 1241
Score = 185 bits (470), Expect = 4e-46
Identities = 206/824 (25%), Positives = 312/824 (37%), Gaps = 70/824 (8%)
Query: 1827 GQDSLLVKIQVIAAPPVILEQRRQVIV-GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVK 1885
G++ LL V+ PP I E R+ V G G+SL L C A G P P + W+
Sbjct: 4 GKEPLLNTGSVV--PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 61
Query: 1886 PLQF-----------TNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTM 1934
PL + L +L+ + D G Y C A + G+ +R L +
Sbjct: 62 PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV 121
Query: 1935 EERVTSPRIEAASQKRTEVNF-GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWI 1993
+T P + A + + G + L C +G P PQ+ W + V+ G +
Sbjct: 122 ---LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG----GPHL 174
Query: 1994 HVYPNGS-LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH 2052
V +G L I D G Y CVA + G + + P + V+
Sbjct: 175 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVME 234
Query: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
Q+ C+A G P P I+W DG ++ + T+ L + +
Sbjct: 235 DHLVQLLCEARGVPTPNITW-FKDGALLPTS---------TKVVYTRGGRQLQLGRAQSS 284
Query: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIK--AGDTAVLDCEVTGDPK 2170
+ G YTC A N +G E L V P I + +K AG L+C G P
Sbjct: 285 DAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 343
Query: 2171 PKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDDTKMYKLD 2229
P + W + + R +GS L + SG Y CVA +P+G+ Y ++
Sbjct: 344 PTLSWHHEGLPVAESNESR--LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 401
Query: 2230 VVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
V P L+ + + T + C+A G+P P + W+ A
Sbjct: 402 VQVPPQLL----VAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR---PAEELAGV 454
Query: 2290 ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVA 2349
+ TL I +V L S F C A NE G + V++ V P +
Sbjct: 455 QVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 514
Query: 2350 QLGKST-------ALNCSVDGNPPPEII--WILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
S+ ++ +P P ++ W P P + I K
Sbjct: 515 XEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS--LWGEPTGIPVAYSLPPPLQIEK 572
Query: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKG--ISGESLSLHCVSDG 2458
D G Y CAA N G ++ V L++ P I PG V + S++L C++ G
Sbjct: 573 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNI---EPGPVNKAVLENASVTLECLASG 629
Query: 2459 IPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLIT 2518
+P P++ W V G + D L I++A D G+Y C A N G T +
Sbjct: 630 VPPPDVSWFKGHQPV---SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELR 686
Query: 2519 VPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERT 2578
+ V PPRIT P +L C A G P P + W + D + +S A T
Sbjct: 687 YGLR-VNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNPVSPAG---T 741
Query: 2579 HGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G + L + + + SDSG Y C A + +G D +QV
Sbjct: 742 PGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV 785
Score = 166 bits (421), Expect = 2e-40
Identities = 118/400 (29%), Positives = 188/400 (47%), Gaps = 33/400 (8%)
Query: 1641 SRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRV 1700
+R + + P ++ + S AFLPC+A G+P P I W + G +S + +
Sbjct: 2748 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTI 2805
Query: 1701 QVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSG 1760
Q P+G L ++ +E QD G Y C+A N G V L+++ P + + ++ G
Sbjct: 2806 Q--PSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP--VFTTLPGDRSLRLG 2861
Query: 1761 STVELKCRAEGRPSPTVTWILANQTV---VSESSQGSRQAVVTVDGTLVLHNLSIYDRGF 1817
+ L+C A G P+P + W + ++ V VSE GS TL +S D G
Sbjct: 2862 DRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGS---------TLQRAAVSREDSGT 2912
Query: 1818 YKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWV 1877
Y C A N G+ + + V A PV+ + +V G S++L C +G P P ++W+
Sbjct: 2913 YVCWAENRVGRTQAVSFVHVKEA-PVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWI 2971
Query: 1878 LSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEER 1937
DG ++ + NG+L IR D G Y+C+A + G ++VV+L ++
Sbjct: 2972 -KDGLPLRGSHLRHQ----LQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQ-- 3024
Query: 1938 VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP 1997
++P + Q T V GD + L C ATGEP P I W Q R + P
Sbjct: 3025 -SAPVFQVEPQDMT-VRSGDDVALRCQATGEPTPTIEW-----LQAGQPLRASRRLRTLP 3077
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP 2037
+GSL++ +V D+G Y CVA N +G + +R +P
Sbjct: 3078 DGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 73.9 bits (180), Expect = 2e-12
Identities = 62/231 (26%), Positives = 104/231 (45%), Gaps = 21/231 (9%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGV 548
VGG++ L+C +GDP P + W + DG +R ++ ++G L ++ + D G
Sbjct: 2950 VGGSIQLDCVVRGDPVPDIHW-IKDGLPLRGSHLRHQ-----LQNGSLTIRRTERDDAGR 3003
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
Y C++ N + + + +V +Q TV G+ + L C +TG P +I W+
Sbjct: 3004 YQCLAEN--EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL 3061
Query: 609 IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQR 668
G + ++SR + L +G+L + V D G Y CVA N G +
Sbjct: 3062 QAGQPL--RASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG----------SATARA 3109
Query: 669 PLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRH 719
L GE +GS + + ++ A L TS + EA G + +S RH
Sbjct: 3110 FLVVRGEPQGS-WGSMTGVINGRKFGVATLNTSVMQEAHSGVSSIHSSIRH 3159
Score = 71.2 bits (173), Expect = 1e-11
Identities = 61/192 (31%), Positives = 87/192 (45%), Gaps = 11/192 (5%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKV---RAPYVSEDGRILIDKS 533
R + EH VL G V L+C G P P V W L DGS + P++ R +D
Sbjct: 1937 RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSPLGQDMGPHL----RFYLD-G 1990
Query: 534 GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVF-IGETLD 592
G L L+ + D G Y C++ N D + + V+ P +G V GE +
Sbjct: 1991 GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVT 2050
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ C G P +SW+ G L S R + TLRI +V D G + CVAA+P+G
Sbjct: 2051 MVCPVRGSPPIHVSWLKDG-LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2109
Query: 653 VDFLIFQVSVKM 664
V F + V++
Sbjct: 2110 VADRNFTLQVQV 2121
Score = 67.0 bits (162), Expect = 2e-10
Identities = 53/174 (30%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
+ TV + V L C G P P V W SK A + + SG LE+ A
Sbjct: 2583 DFTVTMMAPVVLTCHSTGIPAPTVSW-----SKAGAQLGARGSGYRVSPSGALEIGQALP 2637
Query: 544 FDTGVYHCISSN-----YDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHST 598
G Y C + N + + VV+PL + E + LPC ++
Sbjct: 2638 IHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVR-------AVAEEEVLLPCEAS 2690
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
GIP +I+W G NV S +VL G LRI +P+D G Y C+A N +G
Sbjct: 2691 GIPRPTITWQKEGLNVATGVST--QVLPGGQLRIAHASPEDAGNYLCIAKNSAG 2742
Score = 66.6 bits (161), Expect = 3e-10
Identities = 56/189 (29%), Positives = 84/189 (44%), Gaps = 17/189 (8%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
E TV V + L C P+P++ W+ K AP+ + L+ + L++ A
Sbjct: 1268 EVTVTVNNPISLICEALAFPSPNITWM-----KDGAPFEASRNIQLLPGTHGLQILNAQK 1322
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLV----EAYQENGIHHT-VFIGETLDLPCHST 598
D G Y C+ +N + Y + V+ P + E G+ + TL L C S
Sbjct: 1323 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESW 1382
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP---KDQGYYRCVAANPSGVDF 655
+P +I W G V SSR +VL G R+LQ+ P D G Y CVA N +G D
Sbjct: 1383 AVPPPTIRWYKDGQPVT-PSSR-LQVLGEG--RLLQIQPTQVSDSGRYLCVATNVAGEDD 1438
Query: 656 LIFQVSVKM 664
F V +++
Sbjct: 1439 QDFNVLIQV 1447
Score = 65.1 bits (157), Expect = 9e-10
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 9/191 (4%)
Query: 479 NNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LE 537
+N E V+ V L C +G PTP++ W DG+ + +++ + G+ L+
Sbjct: 224 SNETGEVAVMEDHLVQLLCEARGVPTPNITWF-KDGA-----LLPTSTKVVYTRGGRQLQ 277
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCH 596
L A S D GVY C +SN A R+ V V P +E G + L C
Sbjct: 278 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECV 337
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFL 656
+ G P ++SW G V +S+ + + LR+ G Y CVA++P+G L
Sbjct: 338 ARGHPSPTLSWHHEGLPVA-ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVL 396
Query: 657 IFQVSVKMKGQ 667
+ V V++ Q
Sbjct: 397 QYSVEVQVPPQ 407
Score = 64.7 bits (156), Expect = 1e-09
Identities = 47/168 (27%), Positives = 80/168 (47%), Gaps = 10/168 (5%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LELQMADSFDT 546
L G + L C + +P P + W DG ++ ED + G+ L+LQ + D+
Sbjct: 2312 LAPGQLVLECSVEAEPAPKITWH-RDGIVLQ-----EDAHTQFPERGRFLQLQALSTADS 2365
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C + N + + +R+ + V + V + +T LPC + G+P +S
Sbjct: 2366 GDYSCTARNAAGSTSVAFRVEI--HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVS 2423
Query: 607 WVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
W + +S R + +L G+LRI V +D G+Y C+A+N +G D
Sbjct: 2424 WRKDRVPLDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2470
Score = 64.3 bits (155), Expect = 2e-09
Identities = 50/172 (29%), Positives = 71/172 (41%), Gaps = 13/172 (7%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADG--SKVRAPYVSEDGRILIDKSGKLELQMADSF 544
VL +V L C G P P V W S VS DGR+L ++ A
Sbjct: 615 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVL-------RIEQAQLS 667
Query: 545 DTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
D G Y C++SN + L Y + V V P + + V + + L C++TG P
Sbjct: 668 DAGSYRCVASNVAGSTELRYGLRVNVPPRITL--PPSLPGPVLVNTPVRLTCNATGAPSP 725
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVD 654
++ W+ GN V + +V G L + D G Y CVA + G D
Sbjct: 726 TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 777
Score = 62.4 bits (150), Expect = 6e-09
Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 8/176 (4%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
+ G V L C +G P+P + W +G V S + R+ D S L L+ +G
Sbjct: 327 VAGRPVALECVARGHPSPTLSWH-HEGLPVAE---SNESRLETDGS-VLRLESPGEASSG 381
Query: 548 VYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
+Y C++S+ +L Y + V P E T +G+ L+LPC ++G P +I W
Sbjct: 382 LYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 441
Query: 608 VIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+ G + +V + G TL I V G + C A N +G +VSV
Sbjct: 442 LQNGRPA--EELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 495
Score = 61.6 bits (148), Expect = 1e-08
Identities = 49/176 (27%), Positives = 80/176 (45%), Gaps = 16/176 (9%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G V + CP +G P HV WL K P +L L + D G++
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWL-----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIF 2100
Query: 550 HCISSNYDDADILTYRITV-VEPLVEAYQ-ENGIHHTVFIGETLDLPCHSTGIPDASISW 607
C++++ + + V V P++E + +N + V G ++LPC + G+P +SW
Sbjct: 2101 TCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDV--VVVRGSLVELPCEARGVPLPLVSW 2158
Query: 608 VIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+ G +L QS L G +L++ V D G Y CVA + +G FQ++V
Sbjct: 2159 MKDGEPLLSQS------LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2208
Score = 61.6 bits (148), Expect = 1e-08
Identities = 60/194 (30%), Positives = 81/194 (41%), Gaps = 15/194 (7%)
Query: 476 SRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK 535
S N T HT + L C G P P V W DG K+ + + G + S
Sbjct: 2487 SPSNLTLTAHTPAL-----LPCEASGSPKPLVVWW-KDGQKL--DFRLQQGAYRLLPSNA 2538
Query: 536 LELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC 595
L L D+ + C+ SN Y++TV P A + TV + + L C
Sbjct: 2539 LLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDF--TVTMMAPVVLTC 2596
Query: 596 HSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD- 654
HSTGIP ++SW G + + S +V +G L I Q P G Y C A N +GV
Sbjct: 2597 HSTGIPAPTVSWSKAGAQLGARGS-GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2655
Query: 655 ---FLIFQVSVKMK 665
FL Q S +K
Sbjct: 2656 KHVFLTVQASPVVK 2669
Score = 61.2 bits (147), Expect = 1e-08
Identities = 48/177 (27%), Positives = 75/177 (42%), Gaps = 8/177 (4%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V T L C G P P V W K R P R I G L +Q + D
Sbjct: 2402 VSVNQTALLPCQADGVPAPLVSW-----RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDA 2456
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C++SN +D + V+EP A + + T+ LPC ++G P +
Sbjct: 2457 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL--TLTAHTPALLPCEASGSPKPLVV 2514
Query: 607 WVIPGNNVLYQSSRDK-KVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
W G + ++ + ++L + L + P+D + CV +N G ++QV+V
Sbjct: 2515 WWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTV 2571
Score = 60.5 bits (145), Expect = 2e-08
Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 21/179 (11%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V+ G V L C +G P P V W+ DG P +S+ +++ L+L+ + D+
Sbjct: 2136 VVRGSLVELPCEARGVPLPLVSWM-KDGE----PLLSQS----LEQGPSLQLEAVGAGDS 2186
Query: 547 GVYHCISSNYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C++ + +++TV+EP + ++ Q + T G ++L C + G P +
Sbjct: 2187 GTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTP--GAPMELLCDAQGTPQPN 2244
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
I+W G + + N+ R+L+V +D G Y C+A +P+G F+V V+
Sbjct: 2245 ITWHKDGQALTRLEN------NSRATRVLRV--RDAGLYTCLAESPAGAIEKSFRVRVQ 2295
Score = 59.3 bits (142), Expect = 5e-08
Identities = 48/183 (26%), Positives = 77/183 (42%), Gaps = 15/183 (8%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAP--YVSEDGRILIDKSGKLELQMA 541
E TV TV L CP G+P P + WL +P V EDG++ L++ A
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQV-------LQVSTA 1624
Query: 542 DSFDTGVYHCISSNYDDA--DILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
+ D Y C++ N + + T R+ V P + + T + ++ LPC
Sbjct: 1625 EVADAASYMCVAENQAGSAEKLFTLRVQ-VPPRIAGLDLEQV--TAILNSSVSLPCDVHA 1681
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQ 659
P+ ++W + L + TL++ + D G Y C A N +G D + Q
Sbjct: 1682 HPNPEVTW-YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1740
Query: 660 VSV 662
+SV
Sbjct: 1741 LSV 1743
Score = 58.9 bits (141), Expect = 6e-08
Identities = 51/203 (25%), Positives = 80/203 (39%), Gaps = 24/203 (11%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAP-----------YVSED 525
R++ K + + G ++ L C G P P + WL D V P +
Sbjct: 20 REDGRKANVSGMAGQSLTLECDANGFPVPEIVWL-KDAQLVGVPLGWAGYGWDLGWGQVG 78
Query: 526 GRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTV 585
G L+D+ L D+G+Y C + N + + V+ P
Sbjct: 79 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLG 138
Query: 586 FIGETLDLPCHSTGIPDASISW------VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKD 639
G ++L C ++G+P + W V+PG L Q D +VL RI D
Sbjct: 139 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHL-QVQEDGQVL-----RITGSHVGD 192
Query: 640 QGYYRCVAANPSGVDFLIFQVSV 662
+G Y+CVA +P+G FQ+ V
Sbjct: 193 EGRYQCVAFSPAGQQARDFQLRV 215
Score = 57.0 bits (136), Expect = 2e-07
Identities = 47/164 (28%), Positives = 69/164 (42%), Gaps = 9/164 (5%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG L+C P P V W DG P V + +LE+Q A D
Sbjct: 1762 VRVGDKAVLSCETDALPEPTVTWY-KDGQ----PLVLAQRTQALRGGQRLEIQEAQVSDK 1816
Query: 547 GVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G+Y C SN + T+ +TV V P E + + G L L C +G+P ++
Sbjct: 1817 GLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA--GSPLVLTCDVSGVPAPTV 1874
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
+W + + S+ V G L++ ++ P G Y CVA N
Sbjct: 1875 TW-LKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 1917
Score = 56.6 bits (135), Expect = 3e-07
Identities = 51/179 (28%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
+V+ G L C G P P V W DG V A E G L ++ L ++ A +
Sbjct: 987 SVVQDGVATLECNATGKPPPTVTW-ERDGQPVGA----ELGLQLQNQGQSLHVERAQAAH 1041
Query: 546 TGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
TG Y C++ N + ++V V P + + + T + L L C + GIP +
Sbjct: 1042 TGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPA 1101
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
I W V D +L G L++ Q +D G Y C+A+N +G F V V
Sbjct: 1102 IRWFRGEEPV--SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1158
Score = 56.2 bits (134), Expect = 4e-07
Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 8/178 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T + + L C G P P + W + P + L+ L++ D
Sbjct: 1081 TAALHSPLTLLCEAMGIPPPAIRWFRGE-----EPVSPGEDTYLLAGGWMLKMTQTQEQD 1135
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
+G+Y C++SN + + V+ P ++ V G+T L C+ TG P +
Sbjct: 1136 SGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 1195
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTL-RILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
+W G + + + +G L ++LQ G+Y C+AAN G FQ+SV
Sbjct: 1196 TWFKDGRPLARGDAHH--ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1251
Score = 53.9 bits (128), Expect = 2e-06
Identities = 46/171 (26%), Positives = 70/171 (40%), Gaps = 12/171 (7%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
+ ++ +G + L C +G PTP + W + D VSE D L+
Sbjct: 2855 DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQ-----DGGSTLQRAAVSR 2907
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVF-IGETLDLPCHSTGIPD 602
D+G Y C + N + V E V Q + V +G ++ L C G P
Sbjct: 2908 EDSGTYVCWAENRVGRTQAVSFVHVKEAPV--LQGEAFSYLVEPVGGSIQLDCVVRGDPV 2965
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
I W+ G + + S + L NG+L I + D G Y+C+A N GV
Sbjct: 2966 PDIHWIKDG--LPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGV 3014
Score = 53.5 bits (127), Expect = 3e-06
Identities = 41/181 (22%), Positives = 78/181 (43%), Gaps = 8/181 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T ++ +V L C P P V W +A + E+ L+ + L+L A D
Sbjct: 1666 TAILNSSVSLPCDVHAHPNPEVTWY----KDSQALSLGEEV-FLLPGTHTLQLGRARLSD 1720
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI--GETLDLPCHSTGIPDA 603
+G+Y C + N D +++V+ P G V + G+ L C + +P+
Sbjct: 1721 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP 1780
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
+++W G ++ + R + + L I + D+G Y C +N +G F ++V+
Sbjct: 1781 TVTWYKDGQPLVL-AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1839
Query: 664 M 664
+
Sbjct: 1840 V 1840
Score = 52.8 bits (125), Expect = 5e-06
Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 10/174 (5%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G L C +G P P++ W K P +G+ I SG+L ++ + D G Y
Sbjct: 2770 GSHAFLPCKARGSPEPNITW-----DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTY 2824
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C + N +T++ ++ + ++ +G+ L L C + G P I W +
Sbjct: 2825 TCTAENAVGRARRRVHLTIL--VLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2882
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
V S TL+ V+ +D G Y C A N G + V VK
Sbjct: 2883 NDRPVTEGVSEQD---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 2933
Score = 52.0 bits (123), Expect = 8e-06
Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 10/173 (5%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L C P P + W D P + D ++ L++ + + + G Y C +S
Sbjct: 1488 LYCDTNAIPPPDLTWYRED-----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1542
Query: 555 NYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGN 612
N D L Y + V+ P ++ +E TV T+ L C + G P +ISW+ N
Sbjct: 1543 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL--QN 1600
Query: 613 NVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKM 664
+ + S +VL +G L++ D Y CVA N +G +F + V++
Sbjct: 1601 GLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQV 1653
Score = 49.7 bits (117), Expect = 4e-05
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 22/186 (11%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L C G P P + W +G V ++ + G+L + A D G Y CI+
Sbjct: 2685 LPCEASGIPRPTITWQ-KEGLNVATGVSTQ-----VLPGGQLRIAHASPEDAGNYLCIAK 2738
Query: 555 NYDDADILTYRITVVEPLVEAYQENGIHH-TVFIGETLDLPCHSTGIPDASISWVIPGNN 613
N + + R+ V P V ENG+ + G LPC + G P+ +I+W G
Sbjct: 2739 NSAGSAMGKTRLVVQVPPV---IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP 2795
Query: 614 VLYQSSRDKK--VLNNGTLRILQVTPKDQGYYRCVAANPSG-------VDFLIFQVSVKM 664
V S + K + +G L + + +D G Y C A N G + L+ V +
Sbjct: 2796 V---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL 2852
Query: 665 KGQRPL 670
G R L
Sbjct: 2853 PGDRSL 2858
Score = 47.8 bits (112), Expect = 1e-04
Identities = 42/179 (23%), Positives = 73/179 (40%), Gaps = 19/179 (10%)
Query: 498 PGQGDPTPHVDWLLADGSKVRAPYVS---EDGRILIDKSG---------KLELQMADSFD 545
P DP H W G+ + P V G + + +G L+++ D D
Sbjct: 522 PAACDPPVHRGW----GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRD 577
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G+Y C ++N + V+ P + ++ V ++ L C ++G+P +
Sbjct: 578 EGIYTCAATNLAGESKREVALKVLVP--PNIEPGPVNKAVLENASVTLECLASGVPPPDV 635
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKM 664
SW G+ + ++ LRI Q D G YRCVA+N +G L + + V +
Sbjct: 636 SW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 693
Score = 45.4 bits (106), Expect = 7e-04
Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 9/188 (4%)
Query: 482 KLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMA 541
+L +V+ +V L C P P + W K P G L L++ A
Sbjct: 795 ELNVSVVANESVALECQSHAMPPPVLSWW-----KDGRPLEPRPGVHLSADKALLQVDRA 849
Query: 542 DSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
D +D G Y C + N Y + V V P+ + + + TV G L C G+
Sbjct: 850 DVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL--TVREGHPTRLSCECRGV 907
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRIL-QVTPKDQGYYRCVAANPSGVDFLIFQ 659
P ISW G + + + + V G L L Q +G Y C +N G Q
Sbjct: 908 PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 967
Query: 660 VSVKMKGQ 667
+ V + Q
Sbjct: 968 LEVHVPPQ 975
Score = 45.1 bits (105), Expect = 0.001
Identities = 49/185 (26%), Positives = 77/185 (41%), Gaps = 19/185 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDW------LLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
TV G L+C +G P P + W L +G+ ++ +VS GR+L L
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQ--HVSAVGRLLY-------LG 941
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPCHST 598
A G Y C SN ++ V V P + +E +V L C++T
Sbjct: 942 QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT 1001
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVDFLI 657
G P +++W G V + ++ N G +L + + G Y CVA N +G
Sbjct: 1002 GKPPPTVTWERDGQPV--GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK 1059
Query: 658 FQVSV 662
F++SV
Sbjct: 1060 FELSV 1064
Score = 44.3 bits (103), Expect = 0.002
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 6/70 (8%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV G V L C G+PTP ++WL A G +RA S R L D G L L+ ++ D
Sbjct: 3037 TVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRA---SRRLRTLPD--GSLWLENVETGD 3090
Query: 546 TGVYHCISSN 555
G Y C++ N
Sbjct: 3091 AGTYDCVAHN 3100
Score = 43.1 bits (100), Expect = 0.004
Identities = 52/233 (22%), Positives = 88/233 (37%), Gaps = 25/233 (10%)
Query: 435 SLQLNRTAT----TFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVG 490
SLQL T+S + + + +A+ M P + D+ E ++ G
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIE------DSGQPTELSLTPG 2228
Query: 491 GTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYH 550
+ L C QG P P++ W + R S R+L + D G+Y
Sbjct: 2229 APMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR------------DAGLYT 2276
Query: 551 CISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGE-TLDLPCHSTGIPDASISWVI 609
C++ + A ++R+ V P G V + L L C P I+W
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAP-PNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 2335
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
G VL + + + L++ ++ D G Y C A N +G + F+V +
Sbjct: 2336 DG-IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2387
Score = 42.0 bits (97), Expect = 0.008
Identities = 43/194 (22%), Positives = 76/194 (39%), Gaps = 28/194 (14%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKL-ELQMADSFDTG 547
V T+ L C P P + W DG V + R+ + G+L ++Q D+G
Sbjct: 1371 VNSTLTLECESWAVPPPTIRWY-KDGQPV-----TPSSRLQVLGEGRLLQIQPTQVSDSG 1424
Query: 548 VYHCISSNYDDADILTYRITVVEPLV----------------EAYQENGI--HHTVFIGE 589
Y C+++N D + + + P + E G+ + +
Sbjct: 1425 RYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENN 1484
Query: 590 TLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAA 648
L C + IP ++W + + + VL G L+I V ++ G Y C A+
Sbjct: 1485 PAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1542
Query: 649 NPSGVDFLIFQVSV 662
N G D+L +++ V
Sbjct: 1543 NEVGEDWLHYELLV 1556
Score = 34.7 bits (78), Expect = 1.3
Identities = 42/179 (23%), Positives = 64/179 (35%), Gaps = 18/179 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLL--ADGSKVRAPYVSEDGRIL------IDKSGKLE 537
T +VG + L C G P P + WL ++ V+ G L +D SG
Sbjct: 418 TTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFA 477
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH- 596
Q + T S + + + V+E + Y HH+ F D P H
Sbjct: 478 CQATNEAGTAGAEVEVSVHGE-----WAPGVLEVPIGQYHWGXEHHSSF-PAACDPPVHR 531
Query: 597 ---STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ P W PG+ + L+I +V +D+G Y C A N +G
Sbjct: 532 GWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 590
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 245 bits (626), Expect = 4e-64
Identities = 200/736 (27%), Positives = 327/736 (44%), Gaps = 64/736 (8%)
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
N + I R + G Y C+A + GT + V PP+++ +TV G T
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP--APNVTVSPGETAV 418
Query: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
L CR G +TW+ + + + + + ++ A D +L + + D G Y+CVASN
Sbjct: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASN 474
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G V + V AP V + Q + G +K+ C+A G P P + W E
Sbjct: 475 ANGVTRASVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISW----SRES 528
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
+ LQ +S++ + + GTL I+ +A D G Y C AT+ G+++ V L T P
Sbjct: 529 QALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY----TDPPSV 583
Query: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS---- 2000
+A V G++ +L C A+G P P+++W +R G + + P GS
Sbjct: 584 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----------YRGGLEMILAPEGSSSGK 632
Query: 2001 LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDC 2060
L I + E+D+G Y C A N++GD + +++ P + + ++ G+ + C
Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL--GRSALLAC 690
Query: 2061 KASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCY 2120
+A+G P P ++W DG + + A G R+R+ ++G L+F V ++ Y C
Sbjct: 691 RATGRPPPTVTWRRGDGQPLGLRLGAG-RGSRSRQP---DSGVLFFESVAPEDQAPYVCE 746
Query: 2121 AQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEV-TGDPKPKIFWLLPS 2179
A+N GK + + L V AP S+ R+ G L C V G P P+ WL
Sbjct: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 806
Query: 2180 NDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLING 2239
+ S R++ A+GSL +++ +G Y CVA N +G + +L VV PP I+
Sbjct: 807 RPLPPGS--RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHP 863
Query: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLE 2299
T+ + C A G P+P + W N + G V K GTL
Sbjct: 864 TATHHITNEGVPAS-----LPCVASGVPAPTITWTKETNALTSR---GPHYNVSKEGTLL 915
Query: 2300 IRNVRLSDSADFICVARNEGGESVLVVQLEV-----LEMLRRPTFRNPFNEKIVAQLGKS 2354
I D+ ++C A N G S ++L V + M P ++ A+ G+
Sbjct: 916 IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL--QVTAKAGEE 973
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNG--PQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
L+C G+PPP + W T+ S P + +Y + +GS +++ D+G Y C
Sbjct: 974 VTLDCEAKGSPPPLVTW-----TKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECT 1028
Query: 2413 ARNKVGYIEKLVILEI 2428
A N G +L +
Sbjct: 1029 ASNPAGSASHRYVLGV 1044
Score = 226 bits (577), Expect = 2e-58
Identities = 209/731 (28%), Positives = 304/731 (41%), Gaps = 72/731 (9%)
Query: 1899 NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDK 1958
N + I + ++ GTYEC A S G+ R + VT P + V+ G+
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGET 416
Query: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
+L+C GE + W + + RV + SL I + D G Y CVA
Sbjct: 417 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL----SLEISGIIPTDGGRYQCVA 472
Query: 2019 RNKMGDDLILMHVSLRLKPAKIDH--KQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPD 2076
N G + + +R P H Q+F + G + +V C ASG P P ISWS
Sbjct: 473 SNANGVTRASVWLLVREAPQVSIHTSSQHFSQ----GVEVKVSCSASGYPTPHISWSRE- 527
Query: 2077 GTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV 2136
+ A+Q D H + GTL V + G+Y+C A N +G D+ V L
Sbjct: 528 ----SQALQEDSRIHVDAQ------GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL-Y 576
Query: 2137 ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
T P + N + G+ AVL CE +G P P++ W +MI ++G
Sbjct: 577 YTDPPSVSAVNAV-VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSG 631
Query: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
L I + D+G Y C A N GD + +L V P + L + TV + +
Sbjct: 632 KLRIPAAQERDAGTYTCRAVNELGDASAEIQL-AVGHAPQLTELPRDVTVELGRSALLA- 689
Query: 2257 KHFDCRAEGTPSPEVMWIMPDNIFL---TAPYYGSRITVHKNGTLEIRNVRLSDSADFIC 2313
CRA G P P V W D L GSR +G L +V D A ++C
Sbjct: 690 ----CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 745
Query: 2314 VARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSV-DGNPPPEIIWI 2372
ARN G+ +L V + +++ G+ +L C V G P PE W+
Sbjct: 746 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWL 803
Query: 2373 -----LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILE 2427
LP G+R S I ++GS + + +E AG+Y C A N G + V L
Sbjct: 804 KDGRPLPPGSRHS---------IRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 854
Query: 2428 IGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHD 2487
+ P I A + G SL CV+ G+P P I WT + + R Y +
Sbjct: 855 VQVPPRIHPTATHHITN-EGVPASLPCVASGVPAPTITWTKETNALTSR---GPHYNVSK 910
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITN-----RPPRSIVTRT 2542
GTL+I + +A D G Y+C A N+VG + + + + P N P + +
Sbjct: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA 970
Query: 2543 GAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGI 2602
G L C A G P P +TW + ++ +G L G+L + Q DSG
Sbjct: 971 GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR---YG---LLPSGSLRLAQVQVGDSGH 1024
Query: 2603 YKCTAKNPLGS 2613
Y+CTA NP GS
Sbjct: 1025 YECTASNPAGS 1035
Score = 205 bits (522), Expect = 4e-52
Identities = 187/677 (27%), Positives = 279/677 (41%), Gaps = 55/677 (8%)
Query: 1655 AASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVE 1714
A + T+ A L C +G + W R L S RV L + +L I +
Sbjct: 406 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS----TGRVAQLADLSLEISGII 461
Query: 1715 IQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS 1774
D G+Y C ASN G V L V P + ++ + G V++ C A G P+
Sbjct: 462 PTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPT 519
Query: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVK 1834
P ++W +Q + +S + V GTL++ ++ D G Y C A+N G D V
Sbjct: 520 PHISWSRESQALQEDS-----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 574
Query: 1835 IQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+ PP + V+V GE L C A G P P V W + + +
Sbjct: 575 L-YYTDPPSVSAVNAVVLVAV-GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---- 628
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVN 1954
S+G L I D GTY C A + G + L + +P++ + T V
Sbjct: 629 ---SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH---APQLTELPRDVT-VE 681
Query: 1955 FGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRV--GSWIHVYPNGSLFIGSVTEKDSG 2012
G LL C ATG P P + WR + + GS +G LF SV +D
Sbjct: 682 LGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQA 741
Query: 2013 VYLCVARNKMGDDLILMHVSLRL-----KPAKIDHKQYFRKQVLHGKDFQVDC-KASGSP 2066
Y+C ARN G + RL P +I +VL G+ + C +G P
Sbjct: 742 PYVCEARNVFGK----VQAEARLIVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRP 796
Query: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
+PE W L DG + R+++ +G+L+ ++ G Y+C A NT G
Sbjct: 797 LPERHW-LKDGRPLPPG----------SRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
Query: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
V L V+ PRI + T+ G A L C +G P P I W +N + S
Sbjct: 846 SQHRDVEL-VVQVPPRIHPT-ATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 903
Query: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPL-INGLYTNRT 2245
Y G+L I + D+G YVC A N G ++ +L V +KP + +NG
Sbjct: 904 -PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
Query: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRL 2305
++ TA + DC A+G+P P V W P +R + +G+L + V++
Sbjct: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSR---PVPPITNRYGLLPSGSLRLAQVQV 1019
Query: 2306 SDSADFICVARNEGGES 2322
DS + C A N G +
Sbjct: 1020 GDSGHYECTASNPAGSA 1036
Score = 202 bits (513), Expect = 5e-51
Identities = 188/713 (26%), Positives = 298/713 (41%), Gaps = 64/713 (8%)
Query: 1814 DRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPS 1873
+ G Y+C A + G +I V PP ++ + + GE+ L C G +
Sbjct: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV--SPGETAVLSCRVLGEAPYN 430
Query: 1874 VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
+ WV + + L + ++ ++ +L I + +D G Y+C+A+++ G R V L
Sbjct: 431 LTWV----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL 486
Query: 1934 MEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWI 1993
+ E I +SQ ++ G ++ ++CSA+G P P I W S+A+ + S I
Sbjct: 487 VRE-APQVSIHTSSQHFSQ---GVEVKVSCSASGYPTPHISWSRESQALQED-----SRI 537
Query: 1994 HVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHG 2053
HV G+L I V +D+G Y C A N++G D + + P+ V G
Sbjct: 538 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV--G 595
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
++ + C+ASG P P + W MI + + S ++G L +
Sbjct: 596 EEAVLVCEASGVPPPRVIWYRGGLEMI---LAPEGS----------SSGKLRIPAAQERD 642
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKI 2173
G YTC A N LG ++ L V AP++ + + + ++ G +A+L C TG P P +
Sbjct: 643 AGTYTCRAVNELGDASAEIQLAV-GHAPQLTELPR-DVTVELGRSALLACRATGRPPPTV 700
Query: 2174 FWLLPSNDMISFSI-----DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKL 2228
W + + R +G L V D YVC ARN G +L
Sbjct: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
Query: 2229 DVVSK-PPLINGLYTNRTVIKATAVRHSKKHFDCRA-EGTPSPEVMWIMPDNIFLTAPYY 2286
V PP I V++ V C G P PE W+
Sbjct: 761 IVTGHAPPQIASSAPTVRVLEGQPVS-----LPCIVLAGRPLPERHWLKDGRPLPP---- 811
Query: 2287 GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK 2346
GSR ++ +G+L + + + CVA N G V+L V + P +P
Sbjct: 812 GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV----QVPPRIHPTATH 867
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA 2406
+ G +L C G P P I W S GP Y ++ G+ +I++ + +DA
Sbjct: 868 HITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH---YNVSKEGTLLIAQPSAQDA 924
Query: 2407 GKYRCAARNKVGYIEKLVILEIGQKPVI------LTYAPGTVKGISGESLSLHCVSDGIP 2460
G Y C A N VG+ + + L + KP I P V +GE ++L C + G P
Sbjct: 925 GAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984
Query: 2461 KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVG 2513
P + WT S V P I +Y L +G+L + + D G+Y C A N G
Sbjct: 985 PPLVTWTKDSRPV---PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
Score = 195 bits (495), Expect = 6e-49
Identities = 173/577 (29%), Positives = 241/577 (41%), Gaps = 60/577 (10%)
Query: 1670 CEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLF 1729
C A G P P I W+R L +++SR+ V GTL IQ V +D G Y C A+N
Sbjct: 512 CSASGYPTPHISWSRESQAL-----QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV 566
Query: 1730 GTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSE 1789
GTD VTL PP + + V G L C A G P P V W ++
Sbjct: 567 GTDQETVTLYYTD-PPSV-SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILA 624
Query: 1790 SSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRR 1849
S G L + D G Y C A N G S +++ V AP + E R
Sbjct: 625 PEGSS-------SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-LTELPR 676
Query: 1850 QVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQF-----TNSKLFLFSNGTLYI 1904
V V G S L C A G P P+V W DG +PL S+ +G L+
Sbjct: 677 DVTV-ELGRSALLACRATGRPPPTVTWRRGDG---QPLGLRLGAGRGSRSRQPDSGVLFF 732
Query: 1905 RNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCS 1964
++A D+ Y C A + G + L + +P A+S V G + L C
Sbjct: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH--APPQIASSAPTVRVLEGQPVSLPCI 790
Query: 1965 A-TGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
G P P+ W + + GS + +GSL + ++ +G Y CVA N G
Sbjct: 791 VLAGRPLPERHWLKDGRPLPP-----GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
Query: 2024 ----DDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTM 2079
D +++ V R+ P H G + C ASG P P I+W T
Sbjct: 846 SQHRDVELVVQVPPRIHPTATHH------ITNEGVPASLPCVASGVPAPTITW-----TK 894
Query: 2080 INNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA 2139
NA+ + R Y + GTL + + G Y C A NT+G ++ L+V T
Sbjct: 895 ETNALTS-----RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT- 948
Query: 2140 APRIRQSNKTNKRI------KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFH 2193
PRI + N + KAG+ LDCE G P P + W S + + +RY
Sbjct: 949 KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT-NRYGLL 1007
Query: 2194 ANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
+GSL + +V++ DSG Y C A NP+G + Y L V
Sbjct: 1008 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
Score = 169 bits (427), Expect = 4e-41
Identities = 142/492 (28%), Positives = 217/492 (44%), Gaps = 44/492 (8%)
Query: 1645 FEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP 1704
+ P V A + +A L CEA G P P + W R GL++ + S
Sbjct: 577 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGS-----S 629
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
+G L I + +D G Y C A N G + L+ V + P++ E +++TV G +
Sbjct: 630 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA-VGHAPQLTE-LPRDVTVELGRSAL 687
Query: 1765 LKCRAEGRPSPTVTWILANQTVVS---ESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
L CRA GRP PTVTW + + + +GSR G L +++ D+ Y C
Sbjct: 688 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD-SGVLFFESVAPEDQAPYVCE 746
Query: 1822 ASNPGGQDSLLVKIQVIA-APPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLS 1879
A N G+ ++ V APP I V V G+ + LPC G P P +W L
Sbjct: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV-LEGQPVSLPCIVLAGRPLPERHW-LK 804
Query: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
DG + P S+ + ++G+L++ G Y C+AT++ GS+ R V L ++
Sbjct: 805 DGRPLPP----GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ---V 857
Query: 1940 SPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG 1999
PRI + N G L C A+G P P I W + A+ + G +V G
Sbjct: 858 PPRIHPTATHHI-TNEGVPASLPCVASGVPAPTITWTKETNALTSR----GPHYNVSKEG 912
Query: 2000 SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP-----AKIDHKQYFRKQVLHGK 2054
+L I + +D+G Y+C A N +G M +S+ KP + + G+
Sbjct: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972
Query: 2055 DFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
+ +DC+A GSP P ++W+ D + T RY L +G+L +V V +
Sbjct: 973 EVTLDCEAKGSPPPLVTWT-KDSRPVPPI---------TNRYGLLPSGSLRLAQVQVGDS 1022
Query: 2115 GDYTCYAQNTLG 2126
G Y C A N G
Sbjct: 1023 GHYECTASNPAG 1034
Score = 163 bits (412), Expect = 2e-39
Identities = 170/661 (25%), Positives = 263/661 (39%), Gaps = 58/661 (8%)
Query: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
LL++CS ++ R + +++H S N S I ++ + G Y C A
Sbjct: 327 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESG-----NSSWEILRASKAEEGTYECTA 381
Query: 2019 RNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGT 2078
++ G + + P ++ V G+ + C+ G ++W + D
Sbjct: 382 VSRAGTGRAKAQIVVTDPPPQLVPAP--NVTVSPGETAVLSCRVLGEAPYNLTW-VRDWR 438
Query: 2079 MINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVIT 2138
++ + T R + +L + + + G Y C A N G V L ++
Sbjct: 439 VLPAS---------TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL-LVR 488
Query: 2139 AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSL 2198
AP++ + +++ G + C +G P P I W S + S R A G+L
Sbjct: 489 EAPQV-SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS--RIHVDAQGTL 545
Query: 2199 TINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
I V D+G Y C A N G D + L + PP ++ + N V+ A +
Sbjct: 546 IIQGVAPEDAGNYSCQATNEVGTDQETVTL-YYTDPPSVSAV--NAVVLVAVG---EEAV 599
Query: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
C A G P P V+W + AP S +G L I + D+ + C A NE
Sbjct: 600 LVCEASGVPPPRVIWYRGGLEMILAPEGSS------SGKLRIPAAQERDAGTYTCRAVNE 653
Query: 2319 GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL----P 2374
G++ +QL V + + +LG+S L C G PPP + W P
Sbjct: 654 LGDASAEIQLAVGHAPQL----TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 709
Query: 2375 NGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIE-KLVILEIGQKPV 2433
G R G S +G ED Y C ARN G ++ + ++ G P
Sbjct: 710 LGLRLGAGRGSRSRQ-PDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
Query: 2434 ILTYAPGTVKGISGESLSLHC-VSDGIPKPNIKWTMPSGYVVDRPQING-KYILHDNGTL 2491
+ + TV+ + G+ +SL C V G P P W RP G ++ + +G+L
Sbjct: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG-----RPLPPGSRHSIRADGSL 823
Query: 2492 VIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCV 2551
+ A G Y C A N+ G V ++V PPRI I T G L CV
Sbjct: 824 HLDRALQEHAGRYSCVATNTAGSQHRDVE-LVVQVPPRIHPTATHHI-TNEGVPASLPCV 881
Query: 2552 ALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPL 2611
A GVP P ITW ++L S + +GTL+I P D+G Y CTA N +
Sbjct: 882 ASGVPAPTITWTKETNALTSRGP------HYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
Query: 2612 G 2612
G
Sbjct: 936 G 936
Score = 160 bits (406), Expect = 1e-38
Identities = 143/527 (27%), Positives = 214/527 (40%), Gaps = 37/527 (7%)
Query: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI 2153
R + N + + AEEG Y C A + G K + V P++ + N +
Sbjct: 354 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 411
Query: 2154 KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVC 2213
G+TAVL C V G+ + W+ ++ S R A+ SL I+ + D G Y C
Sbjct: 412 SPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQC 470
Query: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMW 2273
VA N +G L +V + P ++ +++ + V+ S C A G P+P + W
Sbjct: 471 VASNANGVTRASVWL-LVREAPQVSIHTSSQHFSQGVEVKVS-----CSASGYPTPHISW 524
Query: 2274 IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
A SRI V GTL I+ V D+ ++ C A NE G V L +
Sbjct: 525 SRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD- 579
Query: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASN 2393
P + N ++ +G+ L C G PPP +IW G P+ +S+
Sbjct: 580 ---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-GGLEMILAPEG-----SSS 630
Query: 2394 GSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLH 2453
G I DAG Y C A N++G + L +G P LT P V G S L
Sbjct: 631 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-LTELPRDVTVELGRSALLA 689
Query: 2454 CVSDGIPKPNIKWTMPSGYVVDRPQINGKYILH---DNGTLVIKEATAYDRGNYICKAQN 2510
C + G P P + W G + G+ D+G L + D+ Y+C+A+N
Sbjct: 690 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 749
Query: 2511 SVGHTLITVPVMIVAY-PPRITNRPPRSIVTRTGAAFQLHCVAL-GVPKPEITWEMPDHS 2568
G +++ + PP+I + P ++ G L C+ L G P PE W + D
Sbjct: 750 VFGKVQAEARLIVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRPLPERHW-LKDGR 807
Query: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
L S+ LHL L +G Y C A N GS +
Sbjct: 808 PLPPGSRHSIRADGSLHLDRAL------QEHAGRYSCVATNTAGSQH 848
Score = 123 bits (308), Expect = 3e-27
Identities = 89/298 (29%), Positives = 133/298 (44%), Gaps = 21/298 (7%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAV-GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG 1706
P + A + + LPC + G PLP HW + D SR + +G
Sbjct: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLK-----DGRPLPPGSRHSIRADG 821
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELK 1766
+L + R + G+Y C A+N G+ H V L VV PPRI T IT + G L
Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHPTATHHIT-NEGVPASLP 879
Query: 1767 CRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPG 1826
C A G P+PT+TW + S + V+ +GTL++ S D G Y C A+N
Sbjct: 880 CVASGVPAPTITWTKETNALTSRGPHYN----VSKEGTLLIAQPSAQDAGAYVCTATNTV 935
Query: 1827 GQDSLLVKIQVIAAPPVILEQRRQV-----IVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
G S +++ V P + + R + GE + L C AKG+P P V W D
Sbjct: 936 GFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT-KDS 994
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
V P+ ++ L +G+L + + D G YEC A++ GS +L ++ R +
Sbjct: 995 RPVPPI---TNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS 1049
Score = 89.0 bits (219), Expect = 6e-17
Identities = 84/336 (25%), Positives = 131/336 (38%), Gaps = 39/336 (11%)
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
N + EI ++ + C A + G Q+ V + P + + G++
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD----PPPQLVPAPNVTVSPGET 416
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG--------SFIISKTTREDA 2406
L+C V G P + W+ + ++ L AS G S IS D
Sbjct: 417 AVLSCRVLGEAPYNLTWV-----------RDWRVLPASTGRVAQLADLSLEISGIIPTDG 465
Query: 2407 GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW 2466
G+Y+C A N G V L + + P + + + G + + C + G P P+I W
Sbjct: 466 GRYQCVASNANGVTRASVWLLVREAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISW 524
Query: 2467 TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY 2526
+ S + + +I+ + GTL+I+ D GNY C+A N VG TV +
Sbjct: 525 SRESQALQEDSRIH----VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETV-TLYYTD 579
Query: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL 2586
PP ++ ++ G L C A GVP P + W ++ GS
Sbjct: 580 PPSVS-AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSS--- 630
Query: 2587 QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G L I Q D+G Y C A N LG A + V
Sbjct: 631 -GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
Score = 63.5 bits (153), Expect = 3e-09
Identities = 45/163 (27%), Positives = 67/163 (41%), Gaps = 12/163 (7%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G V ++C G PTPH+ W + + ED RI +D G L +Q D G Y
Sbjct: 505 GVEVKVSCSASGYPTPHISW------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 558
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C ++N D T + +P + V +GE L C ++G+P + W
Sbjct: 559 SCQATNEVGTDQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR 616
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
G ++ ++G LRI +D G Y C A N G
Sbjct: 617 GGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCRAVNELG 655
Score = 61.6 bits (148), Expect = 1e-08
Identities = 47/181 (25%), Positives = 73/181 (40%), Gaps = 11/181 (6%)
Query: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKL 536
R + T H G L C G P P + W +K S + K G L
Sbjct: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITW-----TKETNALTSRGPHYNVSKEGTL 914
Query: 537 ELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENG----IHHTVFIGETL 591
+ + D G Y C ++N R++V +P + + T GE +
Sbjct: 915 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
Query: 592 DLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPS 651
L C + G P ++W V ++R +L +G+LR+ QV D G+Y C A+NP+
Sbjct: 975 TLDCEAKGSPPPLVTWTKDSRPVPPITNR-YGLLPSGSLRLAQVQVGDSGHYECTASNPA 1033
Query: 652 G 652
G
Sbjct: 1034 G 1034
Score = 58.9 bits (141), Expect = 6e-08
Identities = 53/180 (29%), Positives = 68/180 (37%), Gaps = 10/180 (5%)
Query: 487 VLVGGTVGLNCPG-QGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
VL G V L C G P P WL DG + R I G L L A
Sbjct: 779 VLEGQPVSLPCIVLAGRPLPERHWL-KDGRPL-----PPGSRHSIRADGSLHLDRALQEH 832
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G Y C+++N + + V P HH G LPC ++G+P +I
Sbjct: 833 AGRYSCVATNTAGSQHRDVELVVQVP--PRIHPTATHHITNEGVPASLPCVASGVPAPTI 890
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK 665
+W N L V GTL I Q + +D G Y C A N G ++SV K
Sbjct: 891 TWT-KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
Score = 49.7 bits (117), Expect = 4e-05
Identities = 49/174 (28%), Positives = 69/174 (39%), Gaps = 21/174 (12%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG L C G P P V W + AP S SGKL + A D
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--------SSGKLRIPAAQERDA 643
Query: 547 GVYHCISSNY--DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C + N D + + + L E ++ TV +G + L C +TG P +
Sbjct: 644 GTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD----VTVELGRSALLACRATGRPPPT 699
Query: 605 ISWVIPGNNVL------YQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
++W L + SR ++ ++G L V P+DQ Y C A N G
Sbjct: 700 VTWRRGDGQPLGLRLGAGRGSRSRQP-DSGVLFFESVAPEDQAPYVCEARNVFG 752
Score = 48.1 bits (113), Expect = 1e-04
Identities = 49/178 (27%), Positives = 74/178 (41%), Gaps = 27/178 (15%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD--- 542
TV G T L+C G+ ++ W+ D R+L +G++ Q+AD
Sbjct: 410 TVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPASTGRVA-QLADLSL 455
Query: 543 ------SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH 596
D G Y C++SN + + + V E + + H + G + + C
Sbjct: 456 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCS 513
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
++G P ISW + L + SR V GTL I V P+D G Y C A N G D
Sbjct: 514 ASGYPTPHISWSRE-SQALQEDSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 569
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 476 SRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK 535
SR+ N L+ T G V L+C +G P P V W +K P R + SG
Sbjct: 957 SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTW-----TKDSRPVPPITNRYGLLPSGS 1011
Query: 536 LELQMADSFDTGVYHCISSN 555
L L D+G Y C +SN
Sbjct: 1012 LRLAQVQVGDSGHYECTASN 1031
Score = 37.0 bits (84), Expect = 0.26
Identities = 44/169 (26%), Positives = 62/169 (36%), Gaps = 4/169 (2%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDG-RILIDKSGKLELQMADSF 544
TV +G + L C G P P V W DG + + G R SG L +
Sbjct: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPE 738
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC-HSTGIPDA 603
D Y C + N R+ V + V G+ + LPC G P
Sbjct: 739 DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP 798
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
W+ G L SR + +G+L + + + G Y CVA N +G
Sbjct: 799 ERHWLKDG-RPLPPGSR-HSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 241 bits (616), Expect = 5e-63
Identities = 262/991 (26%), Positives = 399/991 (40%), Gaps = 85/991 (8%)
Query: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
E P K S + C G I W + + + N ++ ++ N
Sbjct: 7209 EVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREI---RPGGNYKMTLVEN 7265
Query: 1706 -GTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
TL++ +V D GQY C ASN+ G D L V PPR +++ V
Sbjct: 7266 TATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQE-PPRFIKKLEPSRIVKQDEFTR 7324
Query: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
+C+ G P V W ++T + ESS+ R + V L +HNLS+ D G Y C A N
Sbjct: 7325 YECKIGGSPEIKVLWY-KDETEIQESSK-FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHN 7382
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWV-----LS 1879
G S ++V P I ++ I G + L C +GTP V W L
Sbjct: 7383 AAGSASSSTSLKV--KEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELR 7440
Query: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
G + K + S+ FL S ++I N+ ++D G Y+C AT+ GS+ V + ++
Sbjct: 7441 SGKKYKIM----SENFLTS---IHILNVDAADIGEYQCKATNDVGSDTCVGSIALK---A 7490
Query: 1940 SPR-IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN 1998
PR ++ S T V G ++ L + G ++W +V + + WI N
Sbjct: 7491 PPRFVKKLSDISTVV--GKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNI--WISYSEN 7546
Query: 1999 -GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQ 2057
+L V ++G Y C +N G +S+ L+PA I K K V G
Sbjct: 7547 IATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV-LEPATIVEKPESIK-VTTGDTCT 7604
Query: 2058 VDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGT-LYFNKVGVAEEGD 2116
++C +G+P W DG + + + + FN + L V ++ G
Sbjct: 7605 LECTVAGTPELSTKW-FKDGKELTS--------DNKYKISFFNKVSGLKIINVAPSDSGV 7655
Query: 2117 YTCYAQNTLGKDEMKVHLTVI--TAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIF 2174
Y+ QN +GKD L V T P + K + +G + V++C+V G P +
Sbjct: 7656 YSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL-SGSSVVMECKVYGSPPISVS 7714
Query: 2175 WLLPSNDMISFSIDRYTFHANG-SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK 2233
W N++ S + T N +LT+N ++ DSG+Y C+A N +G D L V +
Sbjct: 7715 WFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPL-TVRE 7773
Query: 2234 PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVH 2293
PP V+ T V F +GTP V W + + G R V
Sbjct: 7774 PPSFVQKPDPMDVLTGTNVT-----FTSIVKGTPPFSVSWFKGSSELVP----GDRCNVS 7824
Query: 2294 KNGT---LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQ 2350
+ LE+ +V S S ++ C+ NE G++ L + + N ++ +
Sbjct: 7825 LEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYS----IE 7880
Query: 2351 LGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYR 2410
GK L + G PP + W NG + + + I +T EDAG+Y
Sbjct: 7881 KGKPLILEGTFTGTPPISVTW-KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYN 7939
Query: 2411 CAARNKVG---YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWT 2467
C N G +++ILE P VK G+S SL C G P+ + W
Sbjct: 7940 CYIENASGKDSCSAQILILE----PPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWY 7995
Query: 2468 MPSGYVVDRPQINGKYILHDN-GTLVIKEATAYDRGNYICKAQNSVGH----TLITVPVM 2522
G RP K +N TLV + D G YICKA+NSVG T +TV
Sbjct: 7996 --KGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQ 8053
Query: 2523 IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSE 2582
PP +R R + G C G ++W L + + + +
Sbjct: 8054 --KLPPSF-SRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSF--- 8107
Query: 2583 QLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
L TL I S +G Y CTA NP+GS
Sbjct: 8108 -LDNTATLNIFKTDRSLAGQYSCTATNPIGS 8137
Score = 234 bits (596), Expect = 1e-60
Identities = 227/932 (24%), Positives = 380/932 (40%), Gaps = 68/932 (7%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L + ++I G+Y C SN G L V P +R + +V G ++ L+
Sbjct: 5950 LELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKE--PAAFLKRLSDHSVEPGKSIILES 6007
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLH--NLSIYDRGFYKCVASNP 1825
G +VTW + + +VT + T +L N + D G Y C N
Sbjct: 6008 TYTGTLPISVTWKKDGFNITTSEKCN----IVTTEKTCILEILNSTKRDAGQYSCEIENE 6063
Query: 1826 GGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVK 1885
G+D + + P + E + + G+S+ L C GTP+ +V W D T+++
Sbjct: 6064 AGRDVCGALVSTLEPPYFVTEL--EPLEAAVGDSVSLQCQVAGTPEITVSWYKGD-TKLR 6120
Query: 1886 PLQFTNSKLFLFSNG--TLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRI 1943
P T F+N TL + +D G Y C A +S G+ + ++ER P
Sbjct: 6121 P---TPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSF 6177
Query: 1944 EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI 2003
A K E G + L C G Q+ W + D ++ S++ +L I
Sbjct: 6178 -ARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNV--ATLKI 6234
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLR---------LKPAKIDHKQYFRKQVLHGK 2054
SG Y C A N +G ++ R +KP ID V+ G+
Sbjct: 6235 LQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSID--------VIAGE 6286
Query: 2055 DFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
+C +G+ I+WS + + G+ T + N L KVG +
Sbjct: 6287 SADFECHVTGAQPMRITWS-------KDNKEIRPGGNYTIT-CVGNTPHLRILKVGKGDS 6338
Query: 2115 GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIF 2174
G YTC A N +GKD L+V P+ + + +K K G++ L+C+++G P+ K+
Sbjct: 6339 GQYTCQATNDVGKDMCSAQLSV-KEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVS 6397
Query: 2175 WLLPSNDMI-SFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK 2233
W +++ S+ + ++ LTIN+ DSG+Y+C A N GD + L V +
Sbjct: 6398 WFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAP 6457
Query: 2234 PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITV- 2292
P ++T + A++ S C GTP EV+W+ + + +IT
Sbjct: 6458 P-----VFTQKPS-PVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKF--KITSK 6509
Query: 2293 HKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLG 2352
H + +L I N+ SD ++ C A NE G ++ E P F ++ +G
Sbjct: 6510 HFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEP---PRFVKKLSDTSTL-IG 6565
Query: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
+ L V+G P ++W+ G + I + + + ++GKY C
Sbjct: 6566 DAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQ 6625
Query: 2413 ARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGY 2472
+N G E +L + +P + P + +G +L CV G P+ + KW G
Sbjct: 6626 IKNDAGMRECSAVLTV-LEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKW-FKDGR 6683
Query: 2473 VVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIV--AYPPRI 2530
+ + ++ +L I A D+G Y + +NSVG + TV V + PP
Sbjct: 6684 ELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSF 6743
Query: 2531 TNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL 2590
R + + GA+ L C G + W + ++S + + L +L
Sbjct: 6744 I-RKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSL 6802
Query: 2591 VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ + SD+GIY C A N GSD + + V
Sbjct: 6803 L----EPSDTGIYTCVAANVAGSDECSAVLTV 6830
Score = 232 bits (591), Expect = 4e-60
Identities = 222/966 (22%), Positives = 406/966 (42%), Gaps = 53/966 (5%)
Query: 1664 SDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQ-NSRVQVLPNGTLSIQRVEIQDRGQYL 1722
SD L CE G P + W + + SK+ RV V L I + + D G+Y
Sbjct: 4970 SDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVF---NLHITKCDPSDTGEYQ 5026
Query: 1723 CSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILA 1782
C SN G+ +++ PP +++ TV S + G P ++TW+
Sbjct: 5027 CIVSNEGGSCSCSTRVALKE-PPSFIKKIENTTTVLKSSAT-FQSTVAGSPPISITWLKD 5084
Query: 1783 NQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP 1842
+Q + + + V TL + ++ G Y C A N G + + ++ P
Sbjct: 5085 DQ--ILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFL-LVQEPA 5141
Query: 1843 VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTL 1902
I+E+ + V V T + + L C GTP+ V W L DG ++ P ++ S F + +
Sbjct: 5142 QIVEKAKSVDV-TEKDPMTLECVVAGTPELKVKW-LKDGKQIVPSRYF-SMSFENNVASF 5198
Query: 1903 YIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLN 1962
I+++ D G Y + GS L + ++ P K +V G + +
Sbjct: 5199 RIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKV-LGSSIHME 5257
Query: 1963 CSATGEPKPQIMWRLPSKAV-VDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNK 2021
C +G W K + ++R+ + + SL + ++ +D+ Y C N
Sbjct: 5258 CKVSGSLPISAQWFKDGKEISTSAKYRL---VCHERSVSLEVNNLELEDTANYTCKVSNV 5314
Query: 2022 MGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMIN 2081
GDD ++++ P+ + R+Q + + G+P +I W D +++
Sbjct: 5315 AGDDACSGILTVKEPPSFLVKPG--RQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVS 5372
Query: 2082 NAMQADDSGHRTRRYTLFNNGTLYFN--KVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA 2139
+ + T + N V ++ G YTC+ N +G D L ++T
Sbjct: 5373 GP----------KCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML-LVTE 5421
Query: 2140 APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTF-HANGSL 2198
P+ + + +K +KAGD++ L+C++ G P+ ++ W +++ + R TF + +
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVI 5481
Query: 2199 TINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
+N + DSG+++C A+NP+G + K+ +V +PP+ + +++ +++++
Sbjct: 5482 QMNNLSTEDSGDFICEAQNPAGSTSCSTKV-IVKEPPVFSSF---PPIVE--TLKNAEVS 5535
Query: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
+C GTP EV+W ++ Y + + + ++ I NV SD ++ C A+NE
Sbjct: 5536 LECELSGTPPFEVVWYKDKRQLRSSKKY-KIASKNFHTSIHILNVDTSDIGEYHCKAQNE 5594
Query: 2319 GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR 2378
G V +++ E P F + N V G+ L S++G P + W+
Sbjct: 5595 VGSDTCVCTVKLKE---PPRFVSKLNSLTVV-AGEPAELQASIEGAQPIFVQWLKEKEEV 5650
Query: 2379 FSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYA 2438
+ + + +K +AGKY C +N G E + L + +P ++
Sbjct: 5651 IRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMV-LEPAVIVEK 5709
Query: 2439 PGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATA 2498
G + GE+ +L C G P+ +++W G ++ Q + + +L I
Sbjct: 5710 AGPMTVTVGETCTLECKVAGTPELSVEW-YKDGKLLTSSQKHKFSFYNKISSLRILSVER 5768
Query: 2499 YDRGNYICKAQNSVGHTLIT--VPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVP 2556
D G Y + QN+VG + T V V A PP T R ++ GA+ L C G
Sbjct: 5769 QDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRR-LKNTGGVLGASCILECKVAGSS 5827
Query: 2557 KPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYA 2616
+ W ++S A + T TL + + +SD G Y C A N GSD
Sbjct: 5828 PISVAWFHEKTKIVSGAKYQTTFSDNVC----TLQLNSLDSSDMGNYTCVAANVAGSDEC 5883
Query: 2617 ATYIQV 2622
+ V
Sbjct: 5884 RAVLTV 5889
Score = 226 bits (577), Expect = 2e-58
Identities = 225/938 (23%), Positives = 375/938 (39%), Gaps = 80/938 (8%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFG----TDHLHVTLSVVSYPPRILERRTKEITVHSGSTV 1763
L + V+ + G Y C +N G T HL V P +R + +V +GS +
Sbjct: 6891 LELFEVQPLESGDYSCLVTNDAGSASCTTHLFVK------EPATFVKRLADFSVETGSPI 6944
Query: 1764 ELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNL--SIYDRGFYKCV 1821
L+ G P +V+WI + SQ R ++ + + +L L +I D Y C+
Sbjct: 6945 VLEATYTGTPPISVSWIKDEYLI----SQSERCSITMTEKSTILEILESTIEDYAQYSCL 7000
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
N GQD + V+ PP +E V GE L C GTP+ + W +
Sbjct: 7001 IENEAGQDICEALVSVLE-PPYFIEPLEHV-EAVIGEPATLQCKVDGTPEIRISWY-KEH 7057
Query: 1882 TEVKP-----LQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEE 1936
T+++ +QF N+ +L I + SD G Y C A +S G+ +L ++
Sbjct: 7058 TKLRSAPAYKMQFKNNV------ASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKA 7111
Query: 1937 RVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVY 1996
R P A K G + C G Q+ W + D + S++H
Sbjct: 7112 RKLPPFF-ARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNV 7170
Query: 1997 PNGSLFIGSVTEKDSGVYLCVARNKMGD-----DLILMHVSLR----LKPAKIDHKQYFR 2047
+L I + G Y C A N +G LIL + LKP +D
Sbjct: 7171 --ATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVD------ 7222
Query: 2048 KQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFN 2107
+ G+ C +G+ +I+W+ D I G + + N TL
Sbjct: 7223 --LALGESGTFKCHVTGTAPIKITWA-KDNREIR-------PGGNYKMTLVENTATLTVL 7272
Query: 2108 KVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTG 2167
KVG + G YTCYA N GKD L V PR + + ++ +K + +C++ G
Sbjct: 7273 KVGKGDAGQYTCYASNIAGKDSCSAQLGV-QEPPRFIKKLEPSRIVKQDEFTRYECKIGG 7331
Query: 2168 DPKPKIFWLLPSNDMISFSIDRYTF-HANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY 2226
P+ K+ W ++ S R +F + L ++ + + DSG+Y C A N +G +
Sbjct: 7332 SPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391
Query: 2227 KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY 2286
L V +PP+ +K V H +C +GTP V W + Y
Sbjct: 7392 SLK-VKEPPIFRKKPHPIETLKGADV-----HLECELQGTPPFHVSWYKDKRELRSGKKY 7445
Query: 2287 GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK 2346
++ + ++ I NV +D ++ C A N+ G V + + P F ++
Sbjct: 7446 -KIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGS---IALKAPPRFVKKLSD- 7500
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA 2406
I +GK L +++G P ++W G + + + S+ +A
Sbjct: 7501 ISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANA 7560
Query: 2407 GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW 2466
GKY C +N G E L + +P + P ++K +G++ +L C G P+ + KW
Sbjct: 7561 GKYTCQIKNDAGMQECFATLSV-LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKW 7619
Query: 2467 TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIV-- 2524
+ + + +G +I A + D G Y + QN VG T + +
Sbjct: 7620 FKDGKELTSDNKYKISFFNKVSGLKIINVAPS-DSGVYSFEVQNPVGKDSCTASLQVSDR 7678
Query: 2525 AYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQL 2584
PP T R + +G++ + C G P ++W + + +S+ K +T ++
Sbjct: 7679 TVPPSFT-RKLKETNGLSGSSVVMECKVYGSPPISVSW-FHEGNEISSGRKYQTTLTDN- 7735
Query: 2585 HLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
L + + SDSG Y C A N GSD + + V
Sbjct: 7736 --TCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTV 7771
Score = 223 bits (569), Expect = 1e-57
Identities = 242/985 (24%), Positives = 383/985 (38%), Gaps = 91/985 (9%)
Query: 1664 SDAFLPCEAVGNPLPTIHW----TRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRG 1719
+ L C+ G+ ++ W T++ SG ++ TL + ++ D G
Sbjct: 5815 ASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVC------TLQLNSLDSSDMG 5868
Query: 1720 QYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTW 1779
Y C A+N+ G+D L+V P + E E+ G V G P V W
Sbjct: 5869 NYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVL--PGKNVTFTSVIRGTPPFKVNW 5926
Query: 1780 ILANQTVVSESSQGSRQAVVTVD--GTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQV 1837
+ +V +G R + D L L N+ I G Y CV SN GQ S ++
Sbjct: 5927 FRGARELV----KGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRL-F 5981
Query: 1838 IAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLF 1897
+ P L++ V G+S+ L T GT SV W DG + + N +
Sbjct: 5982 VKEPAAFLKRLSDHSVEP-GKSIILESTYTGTLPISVTWK-KDGFNITTSEKCNI-VTTE 6038
Query: 1898 SNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGD 1957
L I N D G Y C + G + +++ E P + E GD
Sbjct: 6039 KTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE----PPYFVTELEPLEAAVGD 6094
Query: 1958 KLLLNCSATGEPKPQIMW-RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLC 2016
+ L C G P+ + W + +K ++R +V +L V DSG Y C
Sbjct: 6095 SVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNV---ATLVFNKVNINDSGEYTC 6151
Query: 2017 VARNKMG--DDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSL 2074
A N +G + + R P + +Q + G + C+ +GS ++ W
Sbjct: 6152 KAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTV-GLPVTLTCRLNGSAPIQVCW-Y 6209
Query: 2075 PDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHL 2134
DG ++ DD +T + N TL + ++ G Y+C A N LG L
Sbjct: 6210 RDGVLLR-----DDENLQTS--FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARL 6262
Query: 2135 TVITAAPRIRQSNKT--------NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
T R+ K+ + + AG++A +C VTG +I W + ++
Sbjct: 6263 TA-------REPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGG 6315
Query: 2187 IDRYTFHANGS---LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTN 2243
YT G+ L I KV DSG+Y C A N G D +L V P + L +
Sbjct: 6316 --NYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEAS 6373
Query: 2244 RTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNV 2303
+ + +++ +C+ G+P +V W D+ + Y ++ L I
Sbjct: 6374 KVAKQGESIQ-----LECKISGSPEIKVSWFRNDSELHESWKYNMSF-INSVALLTINEA 6427
Query: 2304 RLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDG 2363
DS D+IC A N G++ L V + P + A G L C + G
Sbjct: 6428 SAEDSGDYICEAHNGVGDASCSTALTV----KAPPVFTQKPSPVGALKGSDVILQCEISG 6483
Query: 2364 NPPPEIIWI-----LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG 2418
PP E++W+ + N +F + + + S I D G+Y C A N+VG
Sbjct: 6484 TPPFEVVWVKDRKQVRNSKKFKITSKHF------DTSLHILNLEASDVGEYHCKATNEVG 6537
Query: 2419 YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQ 2478
++ + P + T + G+++ L + +G ++ W G V+ R
Sbjct: 6538 SDTCSCSVKFKEPPRFVKKLSDT-STLIGDAVELRAIVEGFQPISVVWLKDRGEVI-RES 6595
Query: 2479 INGKYILHDN-GTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRS 2537
N + DN TL + A + G YIC+ +N G + V+ V P RI +P
Sbjct: 6596 ENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSA-VLTVLEPARIIEKPEPM 6654
Query: 2538 IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQT 2597
VT TG F L CV G P+ W D LS SK H ++ +L I +
Sbjct: 6655 TVT-TGNPFALECVVTGTPELSAKW-FKDGRELSADSK---HHITFINKVASLKIPCAEM 6709
Query: 2598 SDSGIYKCTAKNPLGSDYAATYIQV 2622
SD G+Y KN +G + V
Sbjct: 6710 SDKGLYSFEVKNSVGKSNCTVSVHV 6734
Score = 222 bits (566), Expect = 3e-57
Identities = 246/1015 (24%), Positives = 389/1015 (38%), Gaps = 94/1015 (9%)
Query: 1638 DSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQN 1697
++++ + +P ++ KA T+ L C+ G P ++ W + L S++ +
Sbjct: 5693 ENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKF 5752
Query: 1698 SRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYP-PRILERRTKEIT 1756
S + +L I VE QD G Y N G + V P RR K
Sbjct: 5753 SFYNKI--SSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTG 5810
Query: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG--TLVLHNLSIYD 1814
G++ L+C+ G +V W +VS G++ D TL L++L D
Sbjct: 5811 GVLGASCILECKVAGSSPISVAWFHEKTKIVS----GAKYQTTFSDNVCTLQLNSLDSSD 5866
Query: 1815 RGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSV 1874
G Y CVA+N G D + V P + E ++ G+++ +GTP V
Sbjct: 5867 MGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLP--GKNVTFTSVIRGTPPFKV 5924
Query: 1875 YWVLSDGTEVKP------LQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERR 1928
W VK + T ++L LF N+ S G Y C+ +++ G
Sbjct: 5925 NWFRGARELVKGDRCNIYFEDTVAELELF--------NIDISQSGEYTCVVSNNAGQASC 5976
Query: 1929 VVMLTMEERVTSPRIEAASQKRTE---VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQ 1985
L ++E AA KR V G ++L + TG + W+ +
Sbjct: 5977 TTRLFVKE-------PAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTS 6029
Query: 1986 QHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQY 2045
+ + + L I + T++D+G Y C N+ G D+ VS P + +
Sbjct: 6030 EKC--NIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEP 6087
Query: 2046 FRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLY 2105
V G + C+ +G+P +SW D + R Y N TL
Sbjct: 6088 LEAAV--GDSVSLQCQVAGTPEITVSWYKGDTKLRPTP--------EYRTYFTNNVATLV 6137
Query: 2106 FNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPR------IRQSNKTNKRIKAGDTA 2159
FNKV + + G+YTC A+N++G K TV R RQ + + G
Sbjct: 6138 FNKVNINDSGEYTCKAENSIGTASSK---TVFRIQERQLPPSFARQLKDIEQTV--GLPV 6192
Query: 2160 VLDCEVTGDPKPKIFW-----LLPSNDMISFS-IDRYTFHANGSLTINKVKLLDSGEYVC 2213
L C + G ++ W LL ++ + S +D +L I + L SG+Y C
Sbjct: 6193 TLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNV-----ATLKILQTDLSHSGQYSC 6247
Query: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMW 2273
A NP G + +L ++ P + + + V + F+C G + W
Sbjct: 6248 SASNPLGTASSSARL--TAREPKKSPFFDIKPV-SIDVIAGESADFECHVTGAQPMRITW 6304
Query: 2274 IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
DN + + V L I V DS + C A N+ G+ + QL V E
Sbjct: 6305 -SKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKE- 6362
Query: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASN 2393
P F VA+ G+S L C + G+P ++ W N + + I S
Sbjct: 6363 --PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSW-FRNDSELHESWKYNMSFINSV 6419
Query: 2394 GSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLH 2453
I++ + ED+G Y C A N VG L + + P + T P V + G + L
Sbjct: 6420 ALLTINEASAEDSGDYICEAHNGVGDASCSTALTV-KAPPVFTQKPSPVGALKGSDVILQ 6478
Query: 2454 CVSDGIPKPNIKWTMPSGYVVDRPQI-NGKYI----LHDNGTLVIKEATAYDRGNYICKA 2508
C G P + W V DR Q+ N K H + +L I A D G Y CKA
Sbjct: 6479 CEISGTPPFEVVW------VKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKA 6532
Query: 2509 QNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHS 2568
N VG + V PPR + T G A +L + G + W
Sbjct: 6533 TNEVGSDTCSCSVKF-KEPPRFVKK-LSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGE 6590
Query: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
++ + R + + TL + +P+ S+SG Y C KN G + + V+
Sbjct: 6591 VIRESENTRISFIDNI---ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVL 6642
Score = 216 bits (549), Expect = 3e-55
Identities = 229/927 (24%), Positives = 358/927 (38%), Gaps = 59/927 (6%)
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYP-PRILERRTKEITVHSGSTVEL 1765
TL I + + GQY CSASN GT L + + P + + + + G +
Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTF 7231
Query: 1766 KCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIY--DRGFYKCVAS 1823
KC G +TW N+ E G + V+ T L L + D G Y C AS
Sbjct: 7232 KCHVTGTAPIKITWAKDNR----EIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYAS 7287
Query: 1824 NPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
N G+DS ++ V PP +++ + E + C G+P+ V W D TE
Sbjct: 7288 NIAGKDSCSAQLGV-QEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWY-KDETE 7345
Query: 1884 VKPL-QFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
++ +F S F+ S L + NL+ D G Y C A ++ GS L ++E P
Sbjct: 7346 IQESSKFRMS--FVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKE----PP 7399
Query: 1943 IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG--- 1999
I E G + L C G P + W + + R G +
Sbjct: 7400 IFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKREL-----RSGKKYKIMSENFLT 7454
Query: 2000 SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVD 2059
S+ I +V D G Y C A N +G D + ++L+ P + K+ + GK+ Q+
Sbjct: 7455 SIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFV--KKLSDISTVVGKEVQLQ 7512
Query: 2060 CKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTC 2119
G+ + W G ++ +S + Y+ N TL F++V A G YTC
Sbjct: 7513 TTIEGAEPISVVWFKDKGEIVR------ESDNIWISYSE-NIATLQFSRVEPANAGKYTC 7565
Query: 2120 YAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPS 2179
+N G E L+V+ A + + ++ GDT L+C V G P+ W
Sbjct: 7566 QIKNDAGMQECFATLSVLEPATIVEKPESI--KVTTGDTCTLECTVAGTPELSTKWFKDG 7623
Query: 2180 NDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK--PPL 2236
++ S + + +F S L I V DSG Y +NP G D+ L V + PP
Sbjct: 7624 KELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPS 7683
Query: 2237 INGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG 2296
R + + + S +C+ G+P V W N + Y + +T
Sbjct: 7684 FT-----RKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLT-DNTC 7737
Query: 2297 TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF-RNPFNEKIVAQLGKST 2355
L + + SDS D+ C+A N G L V E P+F + P ++ G +
Sbjct: 7738 ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREP---PSFVQKPDPMDVLT--GTNV 7792
Query: 2356 ALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARN 2415
V G PP + W + G + L S + +G+Y C N
Sbjct: 7793 TFTSIVKGTPPFSVSWF-KGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSN 7851
Query: 2416 KVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD 2475
+ G L I + P G+ L L G P ++ W +G V
Sbjct: 7852 EAGKASCTTHLYI-KAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKK-NGINVT 7909
Query: 2476 RPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPP 2535
Q + L I +T D G Y C +N+ G + ++I+ P + P
Sbjct: 7910 PSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEP 7969
Query: 2536 RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNP 2595
+ G + L C G P+ ++W D L T T+ + TLV
Sbjct: 7970 --VKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTT----TYKMHFRNNVATLVFNQV 8023
Query: 2596 QTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+DSG Y C A+N +G A+T++ V
Sbjct: 8024 DINDSGEYICKAENSVGEVSASTFLTV 8050
Score = 214 bits (544), Expect = 1e-54
Identities = 226/930 (24%), Positives = 357/930 (38%), Gaps = 57/930 (6%)
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELK 1766
TL RVE + G+Y C N G TLSV+ P + + + I V +G T L+
Sbjct: 7549 TLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLE--PATIVEKPESIKVTTGDTCTLE 7606
Query: 1767 CRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPG 1826
C G P + W + + S++ + + L + N++ D G Y NP
Sbjct: 7607 CTVAGTPELSTKWFKDGKELTSDNKY--KISFFNKVSGLKIINVAPSDSGVYSFEVQNPV 7664
Query: 1827 GQDSLLVKIQVI--AAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G+DS +QV PP + ++ G G S+ + C G+P SV W +G E+
Sbjct: 7665 GKDSCTASLQVSDRTVPPSFTRKLKETN-GLSGSSVVMECKVYGSPPISVSW-FHEGNEI 7722
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
+ + L + L + L SD G Y CIAT+ GS+ LT+ E P
Sbjct: 7723 SSGRKYQTTL-TDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE----PPSF 7777
Query: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIG 2004
+V G + G P + W S +V S LF
Sbjct: 7778 VQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELF-- 7835
Query: 2005 SVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASG 2064
V SG Y C+ N+ G H+ ++ PAK K+ + GK ++ +G
Sbjct: 7836 DVDTSQSGEYTCIVSNEAGKASCTTHLYIKA-PAKFV-KRLNDYSIEKGKPLILEGTFTG 7893
Query: 2065 SPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNT 2124
+P ++W N + S R T + L V + G Y CY +N
Sbjct: 7894 TPPISVTWK-------KNGINVTPS-QRCNITTTEKSAILEIPSSTVEDAGQYNCYIENA 7945
Query: 2125 LGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMIS 2184
GKD + ++ ++Q ++ GD+A L C++ G P+ + W +
Sbjct: 7946 SGKDSCSAQILILEPPYFVKQLEPV--KVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRP 8003
Query: 2185 FSIDRYTFHAN-GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK---PPLINGL 2240
+ + F N +L N+V + DSGEY+C A N G+ + L V + P L
Sbjct: 8004 TTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQL 8063
Query: 2241 YTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEI 2300
+ + V FDC G+ V W +P + + TL I
Sbjct: 8064 RDVQETVGLPVV------FDCAISGSEPISVSWYKDGKPLKDSPNVQTSF-LDNTATLNI 8116
Query: 2301 RNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCS 2360
S + + C A N G + +L +L + P F + + A +G+S C
Sbjct: 8117 FKTDRSLAGQYSCTATNPIGSASSSARL-ILTEGKNPPFFDIRLAPVDAVVGESADFECH 8175
Query: 2361 VDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYI 2420
V G P ++ W + S G YL ++ + K + D+G+Y C A N+VG
Sbjct: 8176 VTGTQPIKVSWAKDSREIRSGGKYQISYL-ENSAHLTVLKVDKGDSGQYTCYAVNEVGKD 8234
Query: 2421 EKLVILEIGQK---PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRP 2477
L I ++ P TV+ G S L G + W + + +P
Sbjct: 8235 SCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNN--IEIQP 8292
Query: 2478 QINGKYILHDNGTLV--IKEATAYDRGNYICKAQNSVGHTLITVPVMI-VAYPPRITNRP 2534
N + I N TLV +++A D G Y CK N G L T ++I P + ++
Sbjct: 8293 TSNCE-ITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQH 8351
Query: 2535 PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQ- 2593
+ G QL C G I W + + + S GT V++
Sbjct: 8352 LTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFAS------GTAVLEL 8405
Query: 2594 -NPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ +DSG Y C A N GSD + + +
Sbjct: 8406 RDVAKADSGDYVCKASNVAGSDTTKSKVTI 8435
Score = 210 bits (535), Expect = 1e-53
Identities = 229/930 (24%), Positives = 365/930 (39%), Gaps = 66/930 (7%)
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVV-SYPPRILERRTKEITVHSGSTVEL 1765
+L I R ++ D G+Y C ASN +G+ TL+V +YPP L R K +T G +
Sbjct: 3512 SLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLS-RPKSLTTFVGKAAKF 3570
Query: 1766 KCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNP 1825
C G +P + I S R + L L NL+I DRG Y C ASN
Sbjct: 3571 ICTVTG--TPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNK 3628
Query: 1826 GGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVK 1885
G D ++ +I P I E + + + + L C + +V W DG ++
Sbjct: 3629 FGADICQAELIIIDKPHFIKE--LEPVQSAINKKVHLECQVDEDRKVTVTW-SKDGQKLP 3685
Query: 1886 PLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEA 1945
P + F TL I D GTY C A++ GS +T+ E
Sbjct: 3686 PGK-DYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVRE-------PP 3737
Query: 1946 ASQKRTEVNF----GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSL 2001
+ K+ + ++ G+ L+C G P Q+ W +K + + V L
Sbjct: 3738 SFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKEL--SESNTVRMYFVNSEAIL 3795
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
I V +DSG Y C A N +G D + ++ P+ I K ++ G + + C+
Sbjct: 3796 DITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFI--KTLEPADIVRGTNALLQCE 3853
Query: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKV---GVAEEGDYT 2118
SG+ EISW D I + +++Y LF+ +L ++ A+ G+Y
Sbjct: 3854 VSGTGPFEISW-FKDKKQIRS----------SKKYRLFSQKSLVCLEIFSFNSADVGEYE 3902
Query: 2119 CYAQNTLGK-DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL 2177
C N +GK M HL P + G T L V G + W+
Sbjct: 3903 CVVANEVGKCGCMATHL---LKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMK 3959
Query: 2178 PSNDMISFSIDRYTFHANG--SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPP 2235
+ + +F +NG L I V++ G+Y C+A N +G T + +L +V +P
Sbjct: 3960 GQEVIREDGKIKMSF-SNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGEL-IVKEPA 4017
Query: 2236 LINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKN 2295
I +I+ TA + GTP + W + + Y RI+ N
Sbjct: 4018 KI---IERAELIQVTA--GDPATLEYTVAGTPELKPKWYKDGRPLVASKKY--RISFKNN 4070
Query: 2296 -GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
L+ + L DS + NE G S VL+ P F P + + + +
Sbjct: 4071 VAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPL-RNVDSVVNGT 4129
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAAR 2414
L+C + G+ P + W +G + + + S I + DAG + C A
Sbjct: 4130 CRLDCKIAGSLPMRVSW-FKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRAT 4188
Query: 2415 NKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVV 2474
N VG + L + + P +T PG+ + G ++ L G I+W + +V
Sbjct: 4189 NSVGSKDSSGALIVQEPPSFVT-KPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELV 4247
Query: 2475 DRPQINGKYILHD--NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITN 2532
YI + +L + D G Y CK N G + + V P
Sbjct: 4248 SG---GSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSAN-LFVKEPATFVE 4303
Query: 2533 RPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVI 2592
+ S + + G A QL C G P +ITW D + ++ H + L +
Sbjct: 4304 KLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSK----HRMSFVESTAVLRL 4359
Query: 2593 QNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ DSG Y C A+N GSD+ ++ + V
Sbjct: 4360 TDVGIEDSGEYMCEAQNEAGSDHCSSIVIV 4389
Score = 207 bits (528), Expect = 8e-53
Identities = 243/1008 (24%), Positives = 378/1008 (37%), Gaps = 79/1008 (7%)
Query: 1647 KPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG 1706
+P + K S + L C G P + W + L + + S +
Sbjct: 7584 EPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG- 7642
Query: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYP-PRILERRTKEITVHSGSTVEL 1765
L I V D G Y N G D +L V P R+ KE SGS+V +
Sbjct: 7643 -LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVM 7701
Query: 1766 KCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGT--LVLHNLSIYDRGFYKCVAS 1823
+C+ G P +V+W +E S G + D T L ++ L D G Y C+A+
Sbjct: 7702 ECKVYGSPPISVSWFHEG----NEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIAT 7757
Query: 1824 NPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
N G D + V PP +++ + V T G ++ KGTP SV W +E
Sbjct: 7758 NMAGSDECSAPLTV-REPPSFVQKPDPMDVLT-GTNVTFTSIVKGTPPFSVSW-FKGSSE 7814
Query: 1884 VKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRI 1943
+ P N L S L + ++ +S G Y CI ++ G T + +P
Sbjct: 7815 LVPGDRCNVSLE-DSVAELELFDVDTSQSGEYTCIVSNEAGK----ASCTTHLYIKAPAK 7869
Query: 1944 EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI 2003
+ G L+L + TG P + W+ V Q + + L I
Sbjct: 7870 FVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRC--NITTTEKSAILEI 7927
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKAS 2063
S T +D+G Y C N G D + + P + KQ +V G + C+ +
Sbjct: 7928 PSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFV--KQLEPVKVSVGDSASLQCQLA 7985
Query: 2064 GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLF---NNGTLYFNKVGVAEEGDYTCY 2120
G+P +SW + D T Y + N TL FN+V + + G+Y C
Sbjct: 7986 GTPEIGVSW-----------YKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICK 8034
Query: 2121 AQNTLGKDEMKVHLTVITAA-PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPS 2179
A+N++G+ LTV P + + G V DC ++G + W
Sbjct: 8035 AENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDG 8094
Query: 2180 NDMISFSIDRYTFHAN-GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVS--KPPL 2236
+ + +F N +L I K +G+Y C A NP G + +L + PP
Sbjct: 8095 KPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPP- 8153
Query: 2237 INGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG 2296
+ + + AV F+C GT +V W + Y +I+ +N
Sbjct: 8154 ----FFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKY--QISYLENS 8207
Query: 2297 T-LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKST 2355
L + V DS + C A NE G+ QL + E L P+F +E + G S
Sbjct: 8208 AHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSF 8267
Query: 2356 ALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIIS--KTTREDAGKYRCAA 2413
L V G+ P + W N P S + N + ++ K DAG Y C
Sbjct: 8268 KLEGRVAGSQPITVAWYKNN---IEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKV 8324
Query: 2414 RNKVG--YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG 2471
N G ++++ +KP + V GE + L C G I+W
Sbjct: 8325 SNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGR 8384
Query: 2472 YVVDRPQINGKYILHDNGTLVI--KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPP- 2528
+ + + + +GT V+ ++ D G+Y+CKA N G V I P
Sbjct: 8385 EIKPSDRCSFSFA---SGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAV 8441
Query: 2529 -------RITNR-----PPRSI--VTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTAS 2574
+ R P+SI V +T A F G P P + W L+
Sbjct: 8442 APATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVG--GDPIPNVKWTKGKWRQLNQGG 8499
Query: 2575 KERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ H Q + L I++ +DSG+Y+C A N G + +QV
Sbjct: 8500 RVFIH---QKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544
Score = 204 bits (519), Expect = 9e-52
Identities = 219/991 (22%), Positives = 375/991 (37%), Gaps = 61/991 (6%)
Query: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVL 1703
+ E P+ V AS + A + L C+ G+P + W R L S + + + + +
Sbjct: 5419 VTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSV 5478
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTV 1763
+ + + +D G ++C A N G+ T +V PP + + + V
Sbjct: 5479 --AVIQMNNLSTEDSGDFICEAQNPAGSTSCS-TKVIVKEPP-VFSSFPPIVETLKNAEV 5534
Query: 1764 ELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVAS 1823
L+C G P V W + + SS+ + A ++ + N+ D G Y C A
Sbjct: 5535 SLECELSGTPPFEVVWYKDKRQL--RSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQ 5592
Query: 1824 NPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
N G D+ + +++ P + + +V GE +L + +G V W L + E
Sbjct: 5593 NEVGSDTCVCTVKLKEPPRFVSKLNSLTVVA--GEPAELQASIEGAQPIFVQW-LKEKEE 5649
Query: 1884 VKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRI 1943
V F+ + TL ++ G Y C + G + L V P +
Sbjct: 5650 VIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATL----MVLEPAV 5705
Query: 1944 EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV-DQQHRVGSWIHVYPNGSLF 2002
V G+ L C G P+ + W K + Q+H+ + + SL
Sbjct: 5706 IVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLR 5762
Query: 2003 IGSVTEKDSGVYLCVARNKMGDD--LILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDC 2060
I SV +D+G Y +N +G ++ VS R P + VL G ++C
Sbjct: 5763 ILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVL-GASCILEC 5821
Query: 2061 KASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNG--TLYFNKVGVAEEGDYT 2118
K +GS ++W +++ A + T F++ TL N + ++ G+YT
Sbjct: 5822 KVAGSSPISVAWFHEKTKIVSGA----------KYQTTFSDNVCTLQLNSLDSSDMGNYT 5871
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A N G DE + LTV +++ + G + G P K+ W
Sbjct: 5872 CVAANVAGSDECRAVLTVQEPPSFVKEPEPL--EVLPGKNVTFTSVIRGTPPFKVNWFRG 5929
Query: 2179 SNDMISFS-IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
+ +++ + Y L + + + SGEY CV N +G + +L V +P
Sbjct: 5930 ARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRL-FVKEPAAF 5988
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
++ +V ++ + GT V W D +T + +T K
Sbjct: 5989 LKRLSDHSVEPGKSI-----ILESTYTGTLPISVTW-KKDGFNITTSEKCNIVTTEKTCI 6042
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL 2357
LEI N D+ + C NE G V + LE P + E + A +G S +L
Sbjct: 6043 LEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE----PPYFVTELEPLEAAVGDSVSL 6098
Query: 2358 NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKV 2417
C V G P + W T+ P+ Y + + + +K D+G+Y C A N +
Sbjct: 6099 QCQVAGTPEITVSW-YKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSI 6157
Query: 2418 GYIEKLVILEIGQKPVILTYAP--GTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD 2475
G + I ++ + ++A ++ G ++L C +G + W + D
Sbjct: 6158 GTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRD 6217
Query: 2476 RPQINGKYILHDN-GTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR---IT 2531
+ ++ DN TL I + G Y C A N +G + + A P+
Sbjct: 6218 DENLQTSFV--DNVATLKILQTDLSHSGQYSCSASNPLG--TASSSARLTAREPKKSPFF 6273
Query: 2532 NRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLV 2591
+ P SI G + C G ITW + + + T HL+
Sbjct: 6274 DIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLR---- 6329
Query: 2592 IQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
I DSG Y C A N +G D + + V
Sbjct: 6330 ILKVGKGDSGQYTCQATNDVGKDMCSAQLSV 6360
Score = 199 bits (505), Expect = 4e-50
Identities = 225/931 (24%), Positives = 365/931 (39%), Gaps = 46/931 (4%)
Query: 1690 DLSKRKQNSRVQVLPN-GTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRIL 1748
++ + +N+R+ + N TL + E + G+Y+C N G L+V+ P RI+
Sbjct: 6590 EVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLE-PARII 6648
Query: 1749 ERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLH 1808
E+ + +TV +G+ L+C G P + W + + ++S + +L +
Sbjct: 6649 EK-PEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKH--HITFINKVASLKIP 6705
Query: 1809 NLSIYDRGFYKCVASNPGGQDSLLVKIQVI--AAPPVILEQRRQVIVGTWGESLKLPCTA 1866
+ D+G Y N G+ + V + V PP + + + V G S+ L C
Sbjct: 6706 CAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNA-ILGASVVLECRV 6764
Query: 1867 KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE 1926
G+ SV W DG E+ S F + TL + L SD G Y C+A + GS+
Sbjct: 6765 SGSAPISVGW-FQDGNEIVSGPKCQSS-FSENVCTLNLSLLEPSDTGIYTCVAANVAGSD 6822
Query: 1927 RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ 1986
+LT++E P E EV G L G P ++ W S+ +V +
Sbjct: 6823 ECSAVLTVQE---PPSFEQTPDS-VEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGE 6878
Query: 1987 HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF 2046
S LF V +SG Y C+ N G H+ ++ +PA K+
Sbjct: 6879 SCNISLEDFVTELELF--EVQPLESGDYSCLVTNDAGSASCTTHLFVK-EPATF-VKRLA 6934
Query: 2047 RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
V G ++ +G+P +SW + D +I+ + + S T + T+ L
Sbjct: 6935 DFSVETGSPIVLEATYTGTPPISVSW-IKDEYLISQSERC--SITMTEKSTI-----LEI 6986
Query: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT 2166
+ + + Y+C +N G+D + ++V+ I I G+ A L C+V
Sbjct: 6987 LESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVI--GEPATLQCKVD 7044
Query: 2167 GDPKPKIFWLLPSNDMISFSIDRYTFHAN-GSLTINKVKLLDSGEYVCVARNPSGDDTKM 2225
G P+ +I W + S + F N SL INKV D GEY C A N G
Sbjct: 7045 GTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASS 7104
Query: 2226 YKLDVVSK--PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTA 2283
L + ++ PP + R + F+CR G+ +V W D + L
Sbjct: 7105 AVLVIKARKLPP-----FFARKLKDVHETLGFPVAFECRINGSEPLQVSW-YKDGVLLKD 7158
Query: 2284 PYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPF 2343
VH TL+I S + C A N G + +L +L P F +
Sbjct: 7159 DANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL-ILSEHEVPPFFDLK 7217
Query: 2344 NEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR 2403
+ LG+S C V G P +I W N G L+ + + + K +
Sbjct: 7218 PVSVDLALGESGTFKCHVTGTAPIKITWAKDN-REIRPGGNYKMTLVENTATLTVLKVGK 7276
Query: 2404 EDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPN 2463
DAG+Y C A N G L + + P + + E C G P+
Sbjct: 7277 GDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIK 7336
Query: 2464 IKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI 2523
+ W + + + ++ L + + D G+Y C+A N+ G + + +
Sbjct: 7337 VLWYKDETEIQESSKFRMSFV-DSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKV 7395
Query: 2524 VAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQ 2583
P I + P I T GA L C G P ++W L S K+ SE
Sbjct: 7396 --KEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRS--GKKYKIMSE- 7450
Query: 2584 LHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
+ ++ I N +D G Y+C A N +GSD
Sbjct: 7451 -NFLTSIHILNVDAADIGEYQCKATNDVGSD 7480
Score = 198 bits (503), Expect = 7e-50
Identities = 221/995 (22%), Positives = 386/995 (38%), Gaps = 69/995 (6%)
Query: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVL 1703
+ ++P + KA S + L C G P + W + G + + S
Sbjct: 5136 LVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLK--DGKQIVPSRYFSMSFEN 5193
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVV--SYPPRILERRTKEITVHSGS 1761
+ IQ V QD GQY N FG+ L V+ + PP ++ TK V GS
Sbjct: 5194 NVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKV-LGS 5252
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
++ ++C+ G + W + + +S R +L ++NL + D Y C
Sbjct: 5253 SIHMECKVSGSLPISAQWFKDGKEI--STSAKYRLVCHERSVSLEVNNLELEDTANYTCK 5310
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
SN G D+ + V P +++ RQ + +++ KGTP + W D
Sbjct: 5311 VSNVAGDDACSGILTVKEPPSFLVKPGRQQAIP--DSTVEFKAILKGTPPFKIKWFKDDV 5368
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSD---RGTYECIATSSTGSERRVVMLTMEERV 1938
V + K F+ G+ NL S D G Y C T+ GS+ ML + E
Sbjct: 5369 ELV-----SGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTE-- 5421
Query: 1939 TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMW-RLPSKAVVDQQHRVGSWIHVYP 1997
P+ + V GD L C G P+ +++W R + ++R+ +
Sbjct: 5422 -PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRM---TFIDS 5477
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQ 2057
+ + +++ +DSG ++C A+N G V ++ P + L +
Sbjct: 5478 VAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIV--ETLKNAEVS 5535
Query: 2058 VDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNG---TLYFNKVGVAEE 2114
++C+ SG+P E+ W D + + +++Y + + +++ V ++
Sbjct: 5536 LECELSGTPPFEVVW-YKDKRQLRS----------SKKYKIASKNFHTSIHILNVDTSDI 5584
Query: 2115 GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIF 2174
G+Y C AQN +G D TV P S + + AG+ A L + G +
Sbjct: 5585 GEYHCKAQNEVGSDTCV--CTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQ 5642
Query: 2175 WLLPSNDMISFSID-RYTFHAN-GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVS 2232
WL ++I S + R TF N +L K + ++G+Y+C +N G M L V+
Sbjct: 5643 WLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLE 5702
Query: 2233 KPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITV 2292
++ + T +C+ GTP V W D LT+
Sbjct: 5703 PAVIVEKAGPMTVTVGETCT------LECKVAGTPELSVEW-YKDGKLLTSSQKHKFSFY 5755
Query: 2293 HKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLG 2352
+K +L I +V D+ + +N G+S ++V + P+F + LG
Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRL-KNTGGVLG 5814
Query: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI-ISKTTREDAGKYRC 2411
S L C V G+ P + W T+ +G + YQ + N + ++ D G Y C
Sbjct: 5815 ASCILECKVAGSSPISVAW-FHEKTKIVSGAK-YQTTFSDNVCTLQLNSLDSSDMGNYTC 5872
Query: 2412 AARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG 2471
A N G E +L + Q+P P ++ + G++++ V G P + W +
Sbjct: 5873 VAANVAGSDECRAVLTV-QEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGAR 5931
Query: 2472 YVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI---VAYPP 2528
+V + N Y L + G Y C N+ G T + + A+
Sbjct: 5932 ELVKGDRCN-IYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLK 5990
Query: 2529 RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQG 2588
R+++ G + L G +TW+ D ++T+ K +E+ +
Sbjct: 5991 RLSDHS-----VEPGKSIILESTYTGTLPISVTWK-KDGFNITTSEKCNIVTTEKTCI-- 6042
Query: 2589 TLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L I N D+G Y C +N G D + +
Sbjct: 6043 -LEILNSTKRDAGQYSCEIENEAGRDVCGALVSTL 6076
Score = 195 bits (496), Expect = 4e-49
Identities = 235/1030 (22%), Positives = 389/1030 (37%), Gaps = 87/1030 (8%)
Query: 1621 FDKKPVQEATTSKLLPFD----SLSRYIFEK-PRIVGGKAASFTIPANSDAFLPCEAVGN 1675
F+ +P++ S L+ D S + ++F K P + A F++ S L G
Sbjct: 6894 FEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGT 6953
Query: 1676 PLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLH 1735
P ++ W + +S+ ++ S + L I I+D QY C N G D
Sbjct: 6954 PPISVSW--IKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICE 7011
Query: 1736 VTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSR 1795
+SV+ PP +E + + G L+C+ +G P ++W + + S+ +
Sbjct: 7012 ALVSVLE-PPYFIE-PLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKL--RSAPAYK 7067
Query: 1796 QAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG--QDSLLVKIQVIAAPPVILEQRRQVIV 1853
+LV++ + D G Y C A N G S ++ I+ PP + + V
Sbjct: 7068 MQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDV-H 7126
Query: 1854 GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
T G + C G+ V W DG +K F+ + TL I S G
Sbjct: 7127 ETLGFPVAFECRINGSEPLQVSW-YKDGVLLKD-DANLQTSFVHNVATLQILQTDQSHIG 7184
Query: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQI 1973
Y C A++ G+ L + E P + ++ G+ C TG +I
Sbjct: 7185 QYNCSASNPLGTASSSAKLILSEHEVPPFFD-LKPVSVDLALGESGTFKCHVTGTAPIKI 7243
Query: 1974 MWRLPSKAVVDQQHRVG---SWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMH 2030
W ++ + R G V +L + V + D+G Y C A N G D
Sbjct: 7244 TWAKDNREI-----RPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQ 7298
Query: 2031 VSLRLKPAKIDHKQYFRKQVLHGKDF-QVDCKASGSPVPEISWSLPDGTMINNAMQADDS 2089
+ ++ P I K+ +++ +F + +CK GSP ++ W D T I +
Sbjct: 7299 LGVQEPPRFI--KKLEPSRIVKQDEFTRYECKIGGSPEIKVLW-YKDETEIQES------ 7349
Query: 2090 GHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKT 2149
+ R + + L + + V + GDYTC A N G L V P R+
Sbjct: 7350 -SKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKV-KEPPIFRKKPHP 7407
Query: 2150 NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLT---INKVKLL 2206
+ +K D L+CE+ G P + W ++ S +Y + LT I V
Sbjct: 7408 IETLKGADVH-LECELQGTPPFHVSWYKDKRELRSGK--KYKIMSENFLTSIHILNVDAA 7464
Query: 2207 DSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGT 2266
D GEY C A N G DT + + + + P + L TV+ + EG
Sbjct: 7465 DIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVV------GKEVQLQTTIEGA 7518
Query: 2267 PSPEVMWIM--------PDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
V+W DNI+++ Y I TL+ V +++ + C +N+
Sbjct: 7519 EPISVVWFKDKGEIVRESDNIWIS---YSENI-----ATLQFSRVEPANAGKYTCQIKND 7570
Query: 2319 GGESVLVVQLEVLE---MLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPN 2375
G L VLE ++ +P E I G + L C+V G P W
Sbjct: 7571 AGMQECFATLSVLEPATIVEKP-------ESIKVTTGDTCTLECTVAGTPELSTKWFKDG 7623
Query: 2376 GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQK--PV 2433
S+ + +G II+ D+G Y +N VG L++ + P
Sbjct: 7624 KELTSDNKYKISFFNKVSGLKIIN-VAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPP 7682
Query: 2434 ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI 2493
T G+SG S+ + C G P ++ W G + + + + L +
Sbjct: 7683 SFTRKLKETNGLSGSSVVMECKVYGSPPISVSW-FHEGNEISSGRKYQTTLTDNTCALTV 7741
Query: 2494 KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRP-PRSIVTRTGAAFQLHCVA 2552
D G+Y C A N G + P + V PP +P P ++T T F +
Sbjct: 7742 NMLEESDSGDYTCIATNMAGSDECSAP-LTVREPPSFVQKPDPMDVLTGTNVTFT--SIV 7798
Query: 2553 LGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
G P ++W L+ +R + S + + L + + TS SG Y C N G
Sbjct: 7799 KGTPPFSVSWFKGSSELV---PGDRCNVSLEDSV-AELELFDVDTSQSGEYTCIVSNEAG 7854
Query: 2613 SDYAATYIQV 2622
T++ +
Sbjct: 7855 KASCTTHLYI 7864
Score = 185 bits (470), Expect = 4e-46
Identities = 212/968 (21%), Positives = 366/968 (37%), Gaps = 56/968 (5%)
Query: 1666 AFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN-GTLSIQRVEIQDRGQYLCS 1724
A L C+ G P I W + + L + ++Q N +L I +V+ D G+Y C
Sbjct: 7037 ATLQCKVDGTPEIRISWYKEHTKL---RSAPAYKMQFKNNVASLVINKVDHSDVGEYSCK 7093
Query: 1725 ASNLFGTDHLHVTLSVVSYP-PRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILAN 1783
A N G L + + P R+ K++ G V +CR G V+W
Sbjct: 7094 ADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWY--K 7151
Query: 1784 QTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP-P 1842
V+ + + + V TL + G Y C ASNP G S K+ + P
Sbjct: 7152 DGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVP 7211
Query: 1843 VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSN-GT 1901
+ + + GES C GT + W D E++P N K+ L N T
Sbjct: 7212 PFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWA-KDNREIRP--GGNYKMTLVENTAT 7268
Query: 1902 LYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLL 1961
L + + D G Y C A++ G + L ++E PR + V +
Sbjct: 7269 LTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQE---PPRFIKKLEPSRIVKQDEFTRY 7325
Query: 1962 NCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNK 2021
C G P+ +++W + + S++ L + +++ +DSG Y C A N
Sbjct: 7326 ECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSV--AVLEMHNLSVEDSGDYTCEAHNA 7383
Query: 2022 MGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMIN 2081
G SL++K I K+ + L G D ++C+ G+P +SW + +
Sbjct: 7384 AGS--ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRS 7441
Query: 2082 NAMQADDSGHRTRRYTLFNNG---TLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVIT 2138
++Y + + +++ V A+ G+Y C A N +G D V +
Sbjct: 7442 G-----------KKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTC-VGSIALK 7489
Query: 2139 AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSL 2198
A PR + + G L + G + W +++ S + + ++
Sbjct: 7490 APPRFVKKLSDISTV-VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIA 7548
Query: 2199 TI--NKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
T+ ++V+ ++G+Y C +N +G L V+ ++ + + T
Sbjct: 7549 TLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCT---- 7604
Query: 2257 KHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVAR 2316
+C GTP W D LT+ +K L+I NV SDS + +
Sbjct: 7605 --LECTVAGTPELSTKWFK-DGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQ 7661
Query: 2317 NEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNG 2376
N G+ L+V + P+F E G S + C V G+PP + W G
Sbjct: 7662 NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLS-GSSVVMECKVYGSPPISVSWF-HEG 7719
Query: 2377 TRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILT 2436
S+G + L + + ++ D+G Y C A N G E L + + P +
Sbjct: 7720 NEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQ 7779
Query: 2437 YAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDN-GTLVIKE 2495
P + ++G +++ + G P ++ W S +V + N L D+ L + +
Sbjct: 7780 -KPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVS--LEDSVAELELFD 7836
Query: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGV 2555
G Y C N G T + I A P + R + + G L G
Sbjct: 7837 VDTSQSGEYTCIVSNEAGKASCTTHLYIKA-PAKFVKRLNDYSIEK-GKPLILEGTFTGT 7894
Query: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
P +TW+ ++ + T + L+ I + D+G Y C +N G D
Sbjct: 7895 PPISVTWKKNGINVTPSQRCNITTTEKSAILE----IPSSTVEDAGQYNCYIENASGKDS 7950
Query: 2616 AATYIQVI 2623
+ I ++
Sbjct: 7951 CSAQILIL 7958
Score = 179 bits (454), Expect = 3e-44
Identities = 224/968 (23%), Positives = 364/968 (37%), Gaps = 67/968 (6%)
Query: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727
L C+ G P I W + S + + S V+ L + V I+D G+Y+C A N
Sbjct: 4319 LACKVTGTPPIKITWFANDREIKESSKHRMSFVE--STAVLRLTDVGIEDSGEYMCEAQN 4376
Query: 1728 LFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVV 1787
G+DH + V P + K I V V L G P +TW N +
Sbjct: 4377 EAGSDHCSSIVIVKESP--YFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILR 4434
Query: 1788 SESSQGSRQAVVTVDGTLVLHNLSIY--DRGFYKCVASNPGGQDSLLVKIQVIAAPPVIL 1845
S G + D + L L D G Y+C +N G ++ + P I
Sbjct: 4435 S----GRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFI- 4489
Query: 1846 EQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSN-GTLYI 1904
++ + G + T KG+ +V W L D E+ + N ++ +N +LY+
Sbjct: 4490 -KKIESTSSLRGGTAAFQATLKGSLPITVTW-LKDSDEI--TEDDNIRMTFENNVASLYL 4545
Query: 1905 RNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCS 1964
+ G Y C A + G +R +L+++E T EA S +V GD L
Sbjct: 4546 SGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITE-EAVS---IDVTQGDPATLQVK 4601
Query: 1965 ATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS---LFIGSVTEKDSGVYLCVARNK 2021
+G + W Q+ +GS + + L I S +KDSG Y +N
Sbjct: 4602 FSGTKEITAKWFKDG-----QELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQND 4656
Query: 2022 MGDDLILMHVS-LRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMI 2080
+G ++ L L K+ + + G ++C +GS I W D I
Sbjct: 4657 VGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQW-FKDDQEI 4715
Query: 2081 NNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAA 2140
+ + + S H N L +++ + G YTC A N G ++ HLTV
Sbjct: 4716 SASEKYKFSFHD-------NTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTV--KE 4766
Query: 2141 PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSI-DRYTFHANGSLT 2199
P ++ + L V G I W + ++ S + + + SL
Sbjct: 4767 PPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLE 4826
Query: 2200 INKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKK-H 2258
+ K DSG Y+C N G T L V P I + +R+ +
Sbjct: 4827 LFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFI------KKPSPVLVLRNGQSTT 4880
Query: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
F+C+ GTP V W + N +G + T +I R+ +S ++C ARN+
Sbjct: 4881 FECQITGTPKIRVSWYLDGNEITAIQKHGISF-IDGLATFQISGARVENSGTYVCEARND 4939
Query: 2319 GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR 2378
G + ++L+V E PTF V + L C V G PP E+ W+ N
Sbjct: 4940 AGTASCSIELKVKE---PPTFIRELKPVEVVKY-SDVELECEVTGTPPFEVTWLKNNREI 4995
Query: 2379 FSNGPQSYQYLIASNGSFI---ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL 2435
S S +Y + S I+K D G+Y+C N+ G + + + P +
Sbjct: 4996 RS----SKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFI 5051
Query: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495
T + S + G P +I W + ++D + TL I+
Sbjct: 5052 KKIENTTT-VLKSSATFQSTVAGSPPISITW-LKDDQILDEDDNVYISFVDSVATLQIRS 5109
Query: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGV 2555
G Y C+A+N G ++V P +I + +S+ L CV G
Sbjct: 5110 VDNGHSGRYTCQAKNESG-VERCYAFLLVQEPAQIVEK-AKSVDVTEKDPMTLECVVAGT 5167
Query: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
P+ ++ W ++ + R + + IQ+ DSG Y +N GS
Sbjct: 5168 PELKVKWLKDGKQIVPS----RYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSS 5223
Query: 2616 AATYIQVI 2623
Y++V+
Sbjct: 5224 CDAYLRVL 5231
Score = 171 bits (434), Expect = 7e-42
Identities = 225/994 (22%), Positives = 391/994 (39%), Gaps = 75/994 (7%)
Query: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
E P V S+ + A L C+ G+P+ + W + + +LS+ V
Sbjct: 3735 EPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFK--NNKELSESNTVRMYFVNSE 3792
Query: 1706 GTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVEL 1765
L I V+++D G Y C A N G+D + V+ PP + + + + G+ L
Sbjct: 3793 AILDITDVKVEDSGSYSCEAVNDVGSDSCSTEI-VIKEPPSFI-KTLEPADIVRGTNALL 3850
Query: 1766 KCRAEGRPSPTVTWILANQTVVSESSQG--SRQAVVTVDGTLVLHNLSIYDRGFYKCVAS 1823
+C G ++W + + S S++++V ++ + + + D G Y+CV +
Sbjct: 3851 QCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLE----IFSFNSADVGEYECVVA 3906
Query: 1824 NPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
N G+ + ++ PP + ++ ++ G+++ L +G+ SV W+ G E
Sbjct: 3907 NEVGKCGCMA-THLLKEPPTFV-KKVDDLIALGGQTVTLQAAVRGSEPISVTWM--KGQE 3962
Query: 1884 VKPLQFTNSKLFLFSNG--TLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
V ++ FSNG L I ++ S G Y C+A + GS+ V L ++E +
Sbjct: 3963 V--IREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKE--PAK 4018
Query: 1942 RIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV-DQQHRVGSWIHVYPNGS 2000
IE A + +V GD L + G P+ + W + +V +++R+ +V
Sbjct: 4019 IIERA--ELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNV---AQ 4073
Query: 2001 LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK------QVLHGK 2054
L S DSG Y N++G D +F K V++G
Sbjct: 4074 LKFYSAELHDSGQYTFEISNEVGSS----SCETTFTVLDRDIAPFFTKPLRNVDSVVNG- 4128
Query: 2055 DFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
++DCK +GS +SW DG I + R R + +L +V + +
Sbjct: 4129 TCRLDCKIAGSLPMRVSW-FKDGKEI-------AASDRYRIAFVEGTASLEIIRVDMNDA 4180
Query: 2115 GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIF 2174
G++TC A N++G + L I P + +K + G L G I
Sbjct: 4181 GNFTCRATNSVGSKDSSGAL--IVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIR 4238
Query: 2175 WLLPSNDMISFSIDRYTFHA-NGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK 2233
W + +++S T A SL + VK DSG Y C N +G L V
Sbjct: 4239 WFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEP 4298
Query: 2234 PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVH 2293
+ L ++ + K A + C+ GTP ++ W D + + V
Sbjct: 4299 ATFVEKLEPSQLLKKGDATQ-----LACKVTGTPPIKITWFANDREIKESSKHRMSF-VE 4352
Query: 2294 KNGTLEIRNVRLSDSADFICVARNEGG----ESVLVVQLEVLEMLRRPTFRNPFNEKIVA 2349
L + +V + DS +++C A+NE G S+++V+ P F F + I
Sbjct: 4353 STAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVK-------ESPYFTKEF-KPIEV 4404
Query: 2350 QLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKY 2409
L V G PP EI W N T +G + ++ S I K DAG+Y
Sbjct: 4405 LKEYDVMLLAEVAGTPPFEITWFKDN-TILRSGRKYKTFIQDHLVSLQILKFVAADAGEY 4463
Query: 2410 RCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP 2469
+C N+VG + + + P + T + G + + G + W
Sbjct: 4464 QCRVTNEVGSSICSARVTLREPPSFIKKIEST-SSLRGGTAAFQATLKGSLPITVTWLKD 4522
Query: 2470 SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
S + + I + ++ +L + G Y+C+A+N G + ++ V P
Sbjct: 4523 SDEITEDDNIRMTF-ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSA-LLSVKEPAT 4580
Query: 2530 ITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT 2589
IT VT+ G L G + W D L+ SK + ++ + +
Sbjct: 4581 ITEEAVSIDVTQ-GDPATLQVKFSGTKEITAKW-FKDGQELTLGSKYKISVTDTVSI--- 4635
Query: 2590 LVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L I + + DSG Y +N +G I V+
Sbjct: 4636 LKIISTEKKDSGEYTFEVQNDVGRSSCKARINVL 4669
Score = 168 bits (425), Expect = 7e-41
Identities = 178/752 (23%), Positives = 306/752 (40%), Gaps = 64/752 (8%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFG----TDHLHVTLSVVSYPPRILERRTKEITVHSGSTV 1763
L + V+ G+Y C SN G T HL++ P +R + ++ G +
Sbjct: 7832 LELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKA------PAKFVKRLNDYSIEKGKPL 7885
Query: 1764 ELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVAS 1823
L+ G P +VTW V SQ L + + ++ D G Y C
Sbjct: 7886 ILEGTFTGTPPISVTWKKNGINVTP--SQRCNITTTEKSAILEIPSSTVEDAGQYNCYIE 7943
Query: 1824 NPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
N G+DS +I +I PP ++Q V V G+S L C GTP+ V W D T+
Sbjct: 7944 NASGKDSCSAQI-LILEPPYFVKQLEPVKVSV-GDSASLQCQLAGTPEIGVSWYKGD-TK 8000
Query: 1884 VKPLQFTNSKLFLFSN-GTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
++P T K+ +N TL + +D G Y C A +S G LT++E+ P
Sbjct: 8001 LRPT--TTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPS 8058
Query: 1943 IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF 2002
+ + + G ++ +C+ +G + W K + D + S++ +L
Sbjct: 8059 F-SRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLD--NTATLN 8115
Query: 2003 IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQV-----LHGKDFQ 2057
I +G Y C A N +G S RL + + +F ++ + G+
Sbjct: 8116 IFKTDRSLAGQYSCTATNPIGS----ASSSARLILTEGKNPPFFDIRLAPVDAVVGESAD 8171
Query: 2058 VDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDY 2117
+C +G+ ++SW+ D I SG + + L N+ L KV + G Y
Sbjct: 8172 FECHVTGTQPIKVSWA-KDSREIR-------SGGKYQISYLENSAHLTVLKVDKGDSGQY 8223
Query: 2118 TCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKA--GDTAVLDCEVTGDPKPKIFW 2175
TCYA N +GKD L + + + ++ ++ G++ L+ V G + W
Sbjct: 8224 TCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAW 8283
Query: 2176 LLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDD--TKMYKLDVVS 2232
+ ++ S TF N L + K + D+G Y C N +G T +
Sbjct: 8284 YKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPK 8343
Query: 2233 KPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITV 2292
KPP+ + T TV + V+ S C +G+ + W+ +
Sbjct: 8344 KPPVFDQHLTPVTVSEGEYVQLS-----CHVQGSEPIRIQWLKAGREIKPSDRCSFSFA- 8397
Query: 2293 HKNGT--LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM--LRRPTFRNPFNEKI- 2347
+GT LE+R+V +DS D++C A N G ++ + + + T + + ++
Sbjct: 8398 --SGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLF 8455
Query: 2348 -------VAQLGKSTA-LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIIS 2399
+ + K+TA V G+P P + W + + G + + + I
Sbjct: 8456 FVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIR 8515
Query: 2400 KTTREDAGKYRCAARNKVGYIEKLVILEIGQK 2431
TT+ D+G YRC A N+ G IE V L++ ++
Sbjct: 8516 DTTKTDSGLYRCVAFNEHGEIESNVNLQVDER 8547
Score = 162 bits (409), Expect = 5e-39
Identities = 226/991 (22%), Positives = 365/991 (36%), Gaps = 109/991 (10%)
Query: 1681 HWTRVPSGLDLSKRKQNSRVQVLPNGT--LSIQRVEIQDRGQYLCSASNLFGTDHLHVTL 1738
HW + G++++ + Q V+ + I D G+Y A G + VTL
Sbjct: 3178 HWYK--DGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVA----GRNRSSVTL 3231
Query: 1739 SV-VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQA 1797
V PP++L+ + +TV SG GRP P ++W Q + S G +
Sbjct: 3232 YVNAPEPPQVLQE-LQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL----STGFKCK 3286
Query: 1798 VVTVDG---TLVLHNLSIYDRGFYKCVASNPGG----QDSLLVKIQVIAAP-------PV 1843
+ DG TL+L D Y C A N G SL V++ + +P P
Sbjct: 3287 FLH-DGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPP 3345
Query: 1844 ILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLY 1903
+ Q V + G+ + C GT V W D ++KP +F F L
Sbjct: 3346 AIITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKD-KKIKPSRFFRMTQF-EDTYQLE 3402
Query: 1904 IRNLASSDRGTYECIATSSTGSERRVVMLTME--ERVTSPRIEAASQ------------- 1948
I D GTY +A+++ G L++E E + RIE +
Sbjct: 3403 IAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKI 3462
Query: 1949 KRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQH---RVGSWIHVYPNGSLFIGS 2005
+ EV G C P + W + + + R +I SL I
Sbjct: 3463 EPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI-----SSLEILR 3517
Query: 2006 VTEKDSGVYLCVARNKMG--DDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKAS 2063
D G Y C A N+ G + V+ P + + V GK + C +
Sbjct: 3518 TQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFV--GKAAKFICTVT 3575
Query: 2064 GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQN 2123
G+PV E W DG ++ R N L + + + + G Y+C A N
Sbjct: 3576 GTPVIETIWQ-KDGAALS-------PSPNWRISDAENKHILELSNLTIQDRGVYSCKASN 3627
Query: 2124 TLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFW------LL 2177
G D + L +I I++ I L+C+V D K + W L
Sbjct: 3628 KFGADICQAELIIIDKPHFIKELEPVQSAI--NKKVHLECQVDEDRKVTVTWSKDGQKLP 3685
Query: 2178 PSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
P D D+ +L I KL DSG YVC A N +G + + V P +
Sbjct: 3686 PGKDYKICFEDKI-----ATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFV 3740
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
+ + ++ + R C+ +G+P +V W +N L+ V+
Sbjct: 3741 KKVDPSYLMLPGESAR-----LHCKLKGSPVIQVTW-FKNNKELSESNTVRMYFVNSEAI 3794
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL 2357
L+I +V++ DS + C A N+ G ++ + E P+F + + G + L
Sbjct: 3795 LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE---PPSFIKTLEPADIVR-GTNALL 3850
Query: 2358 NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI---ISKTTREDAGKYRCAAR 2414
C V G P EI W S S +Y + S S + I D G+Y C
Sbjct: 3851 QCEVSGTGPFEISWFKDKKQIRS----SKKYRLFSQKSLVCLEIFSFNSADVGEYECVVA 3906
Query: 2415 NKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVV 2474
N+VG + + + P + + + G++++L G ++ W +
Sbjct: 3907 NEVGKCGCMATHLLKEPPTFVKKVDDLI-ALGGQTVTLQAAVRGSEPISVTWMKGQEVIR 3965
Query: 2475 DRPQINGKYILHDNG--TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITN 2532
+ +I + NG L+I + G Y C A+N G + +V +IV P +I
Sbjct: 3966 EDGKIKMSF---SNGVAVLIIPDVQISFGGKYTCLAENEAG-SQTSVGELIVKEPAKIIE 4021
Query: 2533 RPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVI 2592
R VT G L G P+ + W L+++ + + L+
Sbjct: 4022 RAELIQVT-AGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLK----F 4076
Query: 2593 QNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ + DSG Y N +GS T V+
Sbjct: 4077 YSAELHDSGQYTFEISNEVGSSSCETTFTVL 4107
Score = 102 bits (255), Expect = 4e-21
Identities = 199/971 (20%), Positives = 342/971 (35%), Gaps = 151/971 (15%)
Query: 1617 KKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNP 1676
K + ++K ++E +T++ + +L+ I KPR S T+ A C+ G P
Sbjct: 32537 KSAALEEKSLEEKSTTRKIK-TTLAARILTKPR-------SMTVYEGESARFSCDTDGEP 32588
Query: 1677 LPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHV 1736
+PT+ W R L S R Q + + T I V+ D G Y N G
Sbjct: 32589 VPTVTWLRKGQVLSTSARHQVTTTKY--KSTFEISSVQASDEGNYSVVVENSEGKQEAEF 32646
Query: 1737 TLSV---------VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVV 1787
TL++ V+ PPR+ ++ E V S V+ R + P P+ ++
Sbjct: 32647 TLTIQKARVTEKAVTSPPRV---KSPEPRVKSPEAVKSPKRVKS-PEPSHPKAVSPTETK 32702
Query: 1788 SESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQ 1847
++ + V+ + F K AS + + +V+ V+ A V
Sbjct: 32703 PTPTEKVQHLPVSAPPKITQ---------FLKAEASKEIAKLTCVVESSVLRAKEV---- 32749
Query: 1848 RRQVIVGTW---GESLK------LPCTAKGTPQPSVYWVLSD-------------GTEVK 1885
TW G+ LK +A GT + + + GT
Sbjct: 32750 -------TWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKT 32802
Query: 1886 PLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEA 1945
LQF I SD+ T E T T + E ++S +
Sbjct: 32803 NLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKA-------PEPISSKPVIV 32855
Query: 1946 ASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF--I 2003
+ T V+ ATGEP+P +W KA+ G + G F I
Sbjct: 32856 TGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG----GKYKLSEDKGGFFLEI 32911
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQ----VLHGKDFQVD 2059
DSG+Y C +N G + L +K K Q Q + K V
Sbjct: 32912 HKTDTSDSGLYTCTVKNSAGS--VSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQ 32969
Query: 2060 CKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTC 2119
+ S + + + +++ + + K V EE T
Sbjct: 32970 EEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTS 33029
Query: 2120 YAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPS 2179
A +E++ H + ++ T I G VL + G K W+L
Sbjct: 33030 QAS-----EEVRTHAEI--------KAFSTQMSINEGQRLVLKANIAGATDVK--WVL-- 33072
Query: 2180 NDMISFSIDRYTFHANGS---LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV---VSK 2233
N + + + Y + +GS LTI + D G C+++ G Y L + +S
Sbjct: 33073 NGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSD 33132
Query: 2234 PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVH 2293
P ++ + + V F C G PSPE+ W +N+ ++ S +++
Sbjct: 33133 APAFISQPRSQNINEGQNVL-----FTCEISGEPSPEIEWFK-NNLPISI---SSNVSIS 33183
Query: 2294 KNG---TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRP------------T 2338
++ +LEIRN +SDS + A+N G+ L VL ++ P +
Sbjct: 33184 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTS 33243
Query: 2339 FRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQ--YLIASNGSF 2396
+ F+ + V + S + + + + + S Q ++ S+ SF
Sbjct: 33244 LQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSF 33303
Query: 2397 I-ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCV 2455
+ IS T+ ++ K++ I P + P + G+ L++ C
Sbjct: 33304 MGISNMTQLESS------------TSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACA 33351
Query: 2456 SDGIPKPNIKWTMPSGYVVDRPQINGKYILH---DNGTLVIKEATAYDRGNYICKAQNSV 2512
G P P + W+ + + Q G++ + D TL+I + D G Y N
Sbjct: 33352 FTGEPTPEVTWSCGGRKIHSQEQ--GRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEF 33409
Query: 2513 GHTLITVPVMI 2523
G TV + I
Sbjct: 33410 GSDSATVNIHI 33420
Score = 81.6 bits (200), Expect = 9e-15
Identities = 197/882 (22%), Positives = 297/882 (33%), Gaps = 130/882 (14%)
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTV 1763
P+ T+S V + G A + T L LS S +I TK + +
Sbjct: 814 PHFTVSKISVPKTEHGYEASIAGSAIAT--LQKELSATSSAQKI----TKSVKAPTVKPS 867
Query: 1764 ELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAV-VTVDGTLVLHNLSIYDRGFYKCVA 1822
E + RAE P P + T SE+ ++ V V++ GT V G V
Sbjct: 868 ETRVRAEPTPLPQFPFADTPDTYKSEAGVEVKKEVGVSITGTTVREERFEVLHGREAKVT 927
Query: 1823 SNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGT 1882
+ +++ PP ++ + V V GES+ L C G P P+V W D
Sbjct: 928 ETA----RVPAPVEIPVTPPTLVSGLKNVTV-IEGESVTLECHISGYPSPTVTWYREDYQ 982
Query: 1883 EVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGS----------------- 1925
+ F + F L IR + D G + C A + G+
Sbjct: 983 IESSIDFQIT--FQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEK 1040
Query: 1926 -----------------ERRVVMLT---MEERVTSPRIEAAS--------QKRTEVNFGD 1957
E R V++T + E P AA QK E G
Sbjct: 1041 ETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVE---GG 1097
Query: 1958 KLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCV 2017
++ C G PKP + W+ + S+ L I D+G Y V
Sbjct: 1098 SVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIV 1157
Query: 2018 ARNKMGDD----LILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWS 2073
RNK G+ +L L Y + ++ +V A G E
Sbjct: 1158 VRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKE 1217
Query: 2074 L-PDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTL------- 2125
+ +I M D RT Y + + + +E +Y + TL
Sbjct: 1218 YEKEQALIRKKMAKDTVVVRT--YVEDQEFHISSFEERLIKEIEYR-IIKTTLEELLEED 1274
Query: 2126 GKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISF 2185
G+++M V ++ A S N RI G C+++G P PKI W +
Sbjct: 1275 GEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHG 1334
Query: 2186 SIDRYTFHANG--SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTN 2243
+ F +G SL I V D G Y A N G+ KL V PL Y
Sbjct: 1335 ERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYI- 1393
Query: 2244 RTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNV 2303
T+ + +R R+ SP M +
Sbjct: 1394 PTLEPVSRIRSLSPRSVSRSPIRMSPARM-----------------------SPARMSPA 1430
Query: 2304 RLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVD 2362
R+S AR G + LE L +P F P + K + G++ + V
Sbjct: 1431 RMSP-------ARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLE--GQTARFDLKVV 1481
Query: 2363 GNPPPEIIWILPNGTRFSNGPQSYQYLIASNG--SFIISKTTREDAGKYRCAARNKVGYI 2420
G P PE W +G + N +++ +I +G S II T D+G++ A+N+ G
Sbjct: 1482 GRPMPETFW-FHDGQQIVN-DYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRS 1539
Query: 2421 EKLVILEIGQ-----KPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVV- 2474
VIL + KP+ + V G L + + G P P+I W S +V
Sbjct: 1540 SISVILTVEAVEHQVKPMFVEKLK-NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVP 1598
Query: 2475 ---DRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVG 2513
+ +I G L I + D Y A N G
Sbjct: 1599 HKYPKIRIEG---TKGEAALKIDSTVSQDSAWYTATAINKAG 1637
Score = 78.2 bits (191), Expect = 1e-13
Identities = 133/651 (20%), Positives = 242/651 (37%), Gaps = 86/651 (13%)
Query: 1616 TKKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGN 1675
TKKSD +K + T K P I KP IV G + T+ ++S A +A G
Sbjct: 32824 TKKSD--QKTTESTVTRKTEP--KAPEPISSKPVIVTGLQDT-TVSSDSVAKFAVKATGE 32878
Query: 1676 PLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLH 1735
P PT WT+ G +++ + + L I + + D G Y C+ N G+
Sbjct: 32879 PRPTAIWTK--DGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSS 32936
Query: 1736 VTLSVVSY----PPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESS 1791
L++ + ++ ++T EIT + V+ + + L ++ + +
Sbjct: 32937 CKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKA---------LRSEEIKMSEA 32987
Query: 1792 QGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQV 1851
+ + + + + VL + + K A++ + +V ++ E R
Sbjct: 32988 KSQEKLALKEEASKVLISEEV-----KKSAATS---LEKSIVHEEITKTSQASEEVRTHA 33039
Query: 1852 IVGTW------GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLF----SNGT 1901
+ + E +L A V WVL+ ++ TNS+ + + S+ T
Sbjct: 33040 EIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNG------VELTNSEEYRYGVSGSDQT 33093
Query: 1902 LYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLL 1961
L I+ + D G CI+ + G + LT+ + ++ + + +N G +L
Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLF 33153
Query: 1962 NCSATGEPKPQIMW---RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
C +GEP P+I W LP + + +VY SL I + + DSG Y A
Sbjct: 33154 TCEISGEPSPEIEWFKNNLPIS--ISSNVSISRSRNVY---SLEIRNASVSDSGKYTIKA 33208
Query: 2019 RNKMGD---DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLP 2075
+N G LM + L +P++ +V + SG + S+S
Sbjct: 33209 KNFRGQCSATASLMVLPLVEEPSR-----------------EVVLRTSGDTSLQGSFSSQ 33251
Query: 2076 DGTMINNAMQADDSGHRT---RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEM-- 2130
M + +A S + T ++ + +E + + +G M
Sbjct: 33252 SVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQ 33311
Query: 2131 ------KVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMIS 2184
K+ I P ++ ++ I G + C TG+P P++ W + S
Sbjct: 33312 LESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHS 33371
Query: 2185 FSIDRYTFHANGSLT---INKVKLLDSGEYVCVARNPSGDDTKMYKLDVVS 2232
R+ LT I V+ D G Y N G D+ + + S
Sbjct: 33372 QEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRS 33422
Score = 77.8 bits (190), Expect = 1e-13
Identities = 188/976 (19%), Positives = 345/976 (35%), Gaps = 137/976 (14%)
Query: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQ 1716
S +P + P + W +G++L + + TL I
Sbjct: 32382 SHRVPCGQNTRFILNVQSKPTAEVKWYH--NGVELQESSKIHYTNTSGVLTLEILDCHTD 32439
Query: 1717 DRGQYLCSASNLFGTDHLHVTLSVVS--YPPRILERRTKEIT---------VHSGSTVEL 1765
D G Y +N G + TL V Y +RR +E+ + +
Sbjct: 32440 DSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSF 32499
Query: 1766 KCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNP 1825
K +E S +V + + T ES + + L S+ ++
Sbjct: 32500 KKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK---------- 32549
Query: 1826 GGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYW-----VLSD 1880
S KI+ A ++ + R + GES + C G P P+V W VLS
Sbjct: 32550 ----STTRKIKTTLAARILTKPRSMTVYE--GESARFSCDTDGEPVPTVTWLRKGQVLST 32603
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTM------ 1934
Q T +K T I ++ +SD G Y + +S G + LT+
Sbjct: 32604 SARH---QVTTTKY----KSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVT 32656
Query: 1935 EERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQ--QHRVGSW 1992
E+ VTSP + + R + K + P+ + +K + QH
Sbjct: 32657 EKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLP--- 32713
Query: 1993 IHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH 2052
+ P + F+ + K+ CV + + L V+ K+ +F Q +
Sbjct: 32714 VSAPPKITQFLKAEASKEIAKLTCVVESSV---LRAKEVTWYKDGKKLKENGHF--QFHY 32768
Query: 2053 GKDFQVDCKAS-------GSPVPEISWSLPDGTMINNAM---QADDSGHRTRRYTLFNNG 2102
D + K + G V EIS GT N QA S H
Sbjct: 32769 SADGTYELKINNLTESDQGEYVCEISGE--GGTSKTNLQFMGQAFKSIHEK--------- 32817
Query: 2103 TLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLD 2162
+K+ ++ D K E K I++ P I + + + + A
Sbjct: 32818 ---VSKISETKKSDQKTTESTVTRKTEPKAP-EPISSKPVI-VTGLQDTTVSSDSVAKFA 32872
Query: 2163 CEVTGDPKPKIFWL-----LPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARN 2217
+ TG+P+P W + S D+ F L I+K DSG Y C +N
Sbjct: 32873 VKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFF----LEIHKTDTSDSGLYTCTVKN 32928
Query: 2218 PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPD 2277
+G + KL + + I + + T+ +K + E + + +
Sbjct: 32929 SAGSVSSSCKLTIKA----IKDTEAQKVSTQKTSEITPQKKAVVQEEISQKA----LRSE 32980
Query: 2278 NIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRP 2337
I ++ ++ + + + + + + SA + ++ E + + E +R
Sbjct: 32981 EIKMSEAKSQEKLALKEEASKVLISEEVKKSAA-TSLEKSIVHEEITKTS-QASEEVRTH 33038
Query: 2338 TFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIA-SNGSF 2396
F+ ++ G+ L ++ G ++ W+L NG +N + Y+Y ++ S+ +
Sbjct: 33039 AEIKAFSTQMSINEGQRLVLKANIAG--ATDVKWVL-NGVELTNS-EEYRYGVSGSDQTL 33094
Query: 2397 IISKTTREDAGKYRCAARNKVGYIEKLVIL----EIGQKPVILTYAPGTVKGISGESLSL 2452
I + + D G C ++ K G ++ L E+ P ++ P + G+++
Sbjct: 33095 TIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQ-PRSQNINEGQNVLF 33153
Query: 2453 HCVSDGIPKPNIKW-------TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505
C G P P I+W ++ S + R + + +L I+ A+ D G Y
Sbjct: 33154 TCEISGEPSPEIEWFKNNLPISISSNVSISRSR--------NVYSLEIRNASVSDSGKYT 33205
Query: 2506 CKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTG------AAFQLHCVALGVPKPE 2559
KA+N G T +M++ + P R +V RT +F V + K E
Sbjct: 33206 IKAKNFRGQCSATASLMVLP----LVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQE 33261
Query: 2560 ITWEMPDHSLLSTASK 2575
++ S S+ ++
Sbjct: 33262 ASFSSFSSSSASSMTE 33277
Score = 76.3 bits (186), Expect = 4e-13
Identities = 107/487 (21%), Positives = 191/487 (39%), Gaps = 34/487 (6%)
Query: 1561 QNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSD 1620
+ S++TP A Q + +E+ K E L E + V + K + +
Sbjct: 32956 KTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATS 33015
Query: 1621 FDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTI 1680
+K V E T S + I KA S + N L +A +
Sbjct: 33016 LEKSIVHEEITKT----SQASEEVRTHAEI---KAFSTQMSINEGQRLVLKANIAGATDV 33068
Query: 1681 HWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSV 1740
W V +G++L+ ++ + TL+I++ +D G C + G L++
Sbjct: 33069 KW--VLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTL 33126
Query: 1741 ---VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV-VSESSQGSRQ 1796
+S P + + + ++ G V C G PSP + W N + +S + SR
Sbjct: 33127 SKELSDAPAFISQPRSQ-NINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRS 33185
Query: 1797 AVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTW 1856
V +L + N S+ D G Y A N GQ S + V+ P++ E R+V++ T
Sbjct: 33186 RNVY---SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL---PLVEEPSREVVLRTS 33239
Query: 1857 GE--------SLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTN-SKLFLFSNGTLYIRNL 1907
G+ S + +A + S + + ++F + S + S ++
Sbjct: 33240 GDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMS 33299
Query: 1908 ASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATG 1967
+SS G S+ S+ ML R P+IEA ++ G L + C+ TG
Sbjct: 33300 SSSFMGISNMTQLESSTSK----MLKAGIRGIPPKIEALPSD-ISIDEGKVLTVACAFTG 33354
Query: 1968 EPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLI 2027
EP P++ W + + Q+ + +L I V ++D G+Y N+ G D
Sbjct: 33355 EPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSA 33414
Query: 2028 LMHVSLR 2034
+++ +R
Sbjct: 33415 TVNIHIR 33421
Score = 73.6 bits (179), Expect = 2e-12
Identities = 67/269 (24%), Positives = 109/269 (40%), Gaps = 32/269 (11%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYP--PRILERRTKEITVHSGSTVEL 1765
L +++ + D G Y C SN G+ L + V+ P P + ++ +TV G V+L
Sbjct: 8307 LQVRKAGMNDAGLYTCKVSNDAGSA-LCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQL 8365
Query: 1766 KCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLH--NLSIYDRGFYKCVAS 1823
C +G + W+ A + E R + GT VL +++ D G Y C AS
Sbjct: 8366 SCHVQGSEPIRIQWLKAGR----EIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKAS 8421
Query: 1824 NPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTW---GESLKLPCTAK----------GTP 1870
N G D+ K+ + P V ++ + G E + K G P
Sbjct: 8422 NVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDP 8481
Query: 1871 QPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT---LYIRNLASSDRGTYECIATSSTGSER 1927
P+V W ++ ++F+ G L IR+ +D G Y C+A + G
Sbjct: 8482 IPNVKWTKGKWRQLNQ----GGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIE 8537
Query: 1928 RVVMLTMEERVTSPRIEA---ASQKRTEV 1953
V L ++ER +IE A K+T +
Sbjct: 8538 SNVNLQVDERKKQEKIEGDLRAMLKKTPI 8566
Score = 72.0 bits (175), Expect = 7e-12
Identities = 102/471 (21%), Positives = 161/471 (34%), Gaps = 109/471 (23%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT--LYIRNLASSDRGT 1914
G++ + G P P +W DG ++ + K+ + +GT L I SD G
Sbjct: 1471 GQTARFDLKVVGRPMPETFW-FHDGQQI--VNDYTHKVVIKEDGTQSLIIVPATPSDSGE 1527
Query: 1915 YECIATSSTGSERRVVMLTME--ERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQ 1972
+ +A + G V+LT+E E P K + G +L + ATG P P
Sbjct: 1528 WTVVAQNRAGRSSISVILTVEAVEHQVKPMF-VEKLKNVNIKEGSRLEMKVRATGNPNPD 1586
Query: 1973 IMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS 2032
I+W S +V ++ +L I S +DS Y A NK G D V+
Sbjct: 1587 IVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVN 1646
Query: 2033 LRLKPAKID---------------------------------------------HKQYFR 2047
+ ++ A+ + K +F+
Sbjct: 1647 VEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFK 1706
Query: 2048 KQV--LHGKDF---QVDCKAS--GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFN 2100
K++ L K F +C+ + G P + W L DG + ++ +R R F
Sbjct: 1707 KKLTSLRLKRFGPAHFECRLTPIGDPTMVVEW-LHDGKPL-------EAANRLRMINEFG 1758
Query: 2101 NGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV-----ITAAPRIRQSNKTNKRIKA 2155
+L + + G TC A N G D L V + ++ + K +RI+
Sbjct: 1759 YCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEE 1818
Query: 2156 ------------------------------------GDTAVLDCEVTGDPKPKIFWLLPS 2179
G+TA C VTG P+PK+ W L
Sbjct: 1819 LERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNG 1878
Query: 2180 NDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
+ R + L I K D+GE A NP G KL++
Sbjct: 1879 QLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 67.8 bits (164), Expect = 1e-10
Identities = 132/635 (20%), Positives = 226/635 (35%), Gaps = 97/635 (15%)
Query: 1748 LERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG---T 1804
+ + K++T G +L C+ GRP P + W + ++ SR+ ++ DG T
Sbjct: 30535 IRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-----SRKYKMSSDGRTHT 30589
Query: 1805 LVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVIL-EQRRQVIVGTWGESLKLP 1863
L + D G Y C+A+N G+ K+ + A P ++ G G +L+L
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLH 30649
Query: 1864 CTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLY----IRNL-ASSDRGTYECI 1918
G P P++ W K LQ NS+ N Y ++N+ + G Y+
Sbjct: 30650 VMYIGRPVPAMTWFHGQ----KLLQ--NSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ 30703
Query: 1919 ATSSTGSERRVVMLTMEERVTSPR----IEAASQKRTEVNF------GDKLLLNCSATG- 1967
++ G+ ++ + ++++ P IEA + +++ G + N
Sbjct: 30704 LSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKC 30763
Query: 1968 EPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG--DD 2025
E K W+L S A+ R I ++TE + A+N G D
Sbjct: 30764 EAKEGAEWQLVSSAISVTTCR--------------IVNLTENAGYYFRVSAQNTFGISDP 30809
Query: 2026 LILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQ 2085
L + V + P F K GK P I+ D ++
Sbjct: 30810 LEVSSVVIIKSP--------FEKPGAPGK-------------PTITAVTKDSCVVAWKPP 30848
Query: 2086 ADDSGHRTRRYTLFNNGTLYFNKVGVAEEG-----------------DYTCYAQNTLGKD 2128
A D G + R Y L + V E ++ +N G+
Sbjct: 30849 ASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGES 30908
Query: 2129 EMKVHLTVIT-------AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSND 2181
E IT AP ++ + N ++ A L C+VTG PKP + W +
Sbjct: 30909 EWSEISEPITPKSDVPIQAPHFKEELR-NLNVRYQSNATLVCKVTGHPKPIVKWYRQGKE 30967
Query: 2182 MISFSIDRYTFHANG---SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLIN 2238
+I+ + G L I V D+ Y A N G + L+ V P I+
Sbjct: 30968 IIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLE-VEVPAKIH 31026
Query: 2239 GLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTL 2298
T + A+R G P P + W ++ +Y +T +
Sbjct: 31027 LPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLV 31086
Query: 2299 EIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
V D+ ++ A+N G V+L+V ++
Sbjct: 31087 FPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADV 31121
Score = 66.6 bits (161), Expect = 3e-10
Identities = 167/824 (20%), Positives = 307/824 (37%), Gaps = 129/824 (15%)
Query: 1690 DLSKRKQNSRVQVLPNGT---LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR 1746
D ++ K+ + ++ G L I + + D +Y C + L V
Sbjct: 12409 DGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGML-----TVLEEEA 12463
Query: 1747 ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGT-- 1804
+ + I V T++L C +P V W ++ ++ + R ++T
Sbjct: 12464 VFTKNLANIEVSETDTIKLVCEVS-KPGAEVIWYKGDEEII----ETGRYEILTEGRKRI 12518
Query: 1805 LVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPC 1864
LV+ N + D G Y C P + VK+ +AA + Q +++ G E + C
Sbjct: 12519 LVIQNAHLEDAGNYNCRL--PSSRTDGKVKVHELAAEFISKPQNLEILEG---EKAEFVC 12573
Query: 1865 TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG---TLYIRNLASSDRGTYECIATS 1921
+ P V W D K L+ + K + ++G L +++ D GTY +
Sbjct: 12574 SISKESFP-VQWKRDD----KTLE-SGDKYDVIADGKKRVLVVKDATLQDMGTYVVMV-- 12625
Query: 1922 STGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKA 1981
G+ R LT+ E++ RI K T V +++ NC E + W +A
Sbjct: 12626 --GAARAAAHLTVIEKL---RI-VVPLKDTRVKEQQEVVFNCEVNTEGA-KAKWFRNEEA 12678
Query: 1982 VVDQ-QHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDD------LILMHVSLR 2034
+ D ++ + VY +L I D Y N G++ LI+ LR
Sbjct: 12679 IFDSSKYIILQKDLVY---TLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLR 12735
Query: 2035 LKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTR 2094
+ D + +K V CK + V + W+ N + +
Sbjct: 12736 IVEPLKDIETMEKKSVTFW------CKVNRLNVT-LKWT-------KNGEEVPFDNRVSY 12781
Query: 2095 RYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIK 2154
R + + L G +EG+Y T G+D+ L +I A P + ++ +
Sbjct: 12782 RVDKYKH-MLTIKDCGFPDEGEYIV----TAGQDKSVAELLIIEA-PTEFVEHLEDQTVT 12835
Query: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS---LTINKVKLLDSGEY 2211
D AV C+++ + K + W ++ +Y F +GS L I +L D EY
Sbjct: 12836 EFDDAVFSCQLSRE-KANVKWYRNGREIKEGK--KYKFEKDGSIHRLIIKDCRLDDECEY 12892
Query: 2212 VCVARNPSGDDTKMYKLDV---VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPS 2268
C + +++ ++ + +PP V+ + K
Sbjct: 12893 ACGVEDRKSR-ARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKDKV----------- 12940
Query: 2269 PEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQL 2328
EV W+ + + + + ++ K L+I +++ D ++ +A+++ + L
Sbjct: 12941 -EVQWLRNNMVVVQGDKH-QMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKL---- 12994
Query: 2329 EVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQY 2388
E+ P + ++ +V +GK + D P E W N P S +
Sbjct: 12995 ---ELAAAPKIKTA-DQDLVVDVGKPLTMVVPYDAYPKAEAEWFK------ENEPLSTKT 13044
Query: 2389 L--IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGIS 2446
+ A SF I + + D G+Y+ +NK G E + L++ PG V+
Sbjct: 13045 IDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKV-------IDVPGPVR--- 13094
Query: 2447 GESLSLHCVSDGIPKPNIKWTMP--------SGYVVDRPQINGK 2482
+L + DG + ++ W P GYVV+R I K
Sbjct: 13095 --NLEVTETFDG--EVSLAWEEPLTDGGSKIIGYVVERRDIKRK 13134
Score = 62.8 bits (151), Expect = 4e-09
Identities = 51/188 (27%), Positives = 77/188 (40%), Gaps = 17/188 (9%)
Query: 2051 LHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGT--LYFNK 2108
L G+ + D K G P+PE W DG I N T + + +GT L
Sbjct: 1469 LEGQTARFDLKVVGRPMPETFW-FHDGQQIVNDY--------THKVVIKEDGTQSLIIVP 1519
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQ---SNKTNKRIKAGDTAVLDCEV 2165
++ G++T AQN G+ + V LTV +++ N IK G +
Sbjct: 1520 ATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRA 1579
Query: 2166 TGDPKPKIFWLLPSNDMISFSIDRYTFH---ANGSLTINKVKLLDSGEYVCVARNPSGDD 2222
TG+P P I WL S+ ++ + +L I+ DS Y A N +G D
Sbjct: 1580 TGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRD 1639
Query: 2223 TKMYKLDV 2230
T K++V
Sbjct: 1640 TTRCKVNV 1647
Score = 62.4 bits (150), Expect = 6e-09
Identities = 108/536 (20%), Positives = 194/536 (36%), Gaps = 121/536 (22%)
Query: 1654 KAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRV 1713
K SF A + VG P+P W + +V + +GT S+ V
Sbjct: 1462 KPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQI---VNDYTHKVVIKEDGTQSLIIV 1518
Query: 1714 EI--QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRI---LERRTKEITVHSGSTVELKCR 1768
D G++ A N G + V L+V + ++ + K + + GS +E+K R
Sbjct: 1519 PATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVR 1578
Query: 1769 AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQ 1828
A G P+P + W+ + +V R + L + + D +Y A N G+
Sbjct: 1579 ATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGR 1638
Query: 1829 DSLLVKIQV---IAAPPVILEQRRQVIV--GTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
D+ K+ V A P E R++I+ GT+ AK P E
Sbjct: 1639 DTTRCKVNVEVEFAEP----EPERKLIIPRGTY--------RAKEIAAP----------E 1676
Query: 1884 VKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRI 1943
++PL + + G LY + + ++++TS R+
Sbjct: 1677 LEPLHLRYGQ-EQWEEGDLY---------------------DKEKQQKPFFKKKLTSLRL 1714
Query: 1944 EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI 2003
+ E + G+P + W K ++ +R+ I+ + SL
Sbjct: 1715 KRFGPAHFECRL--------TPIGDPTMVVEWLHDGKP-LEAANRL-RMINEFGYCSLDY 1764
Query: 2004 GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQY--FRK------------- 2048
G +DSG+ C A NK G D + ++ + + ++ Q RK
Sbjct: 1765 GVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAH 1824
Query: 2049 --------------------------QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINN 2082
+VL G+ + C+ +G P P+++W L +G +I
Sbjct: 1825 EGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYL-NGQLI-- 1881
Query: 2083 AMQADDSGHRTRRYTLFNNGTLYFNKVGVA--EEGDYTCYAQNTLGKDEMKVHLTV 2136
+++R+ + +G Y + V + G+ A+N G E KV L +
Sbjct: 1882 --------RKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 62.0 bits (149), Expect = 7e-09
Identities = 114/490 (23%), Positives = 187/490 (38%), Gaps = 50/490 (10%)
Query: 1673 VGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT-LSIQRVEIQDR-GQYLCSASNLFG 1730
+G P+P + W G L + +N ++ + T L ++ V+ + G+Y SN+FG
Sbjct: 30653 IGRPVPAMTWFH---GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFG 30709
Query: 1731 TDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSES 1790
T + + + P + E + + + + K A+ S WI E+
Sbjct: 30710 TVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGS----WITNYVVEKCEA 30765
Query: 1791 SQGSRQAVVTVD---GTLVLHNLSIYDRGFYKCVASNPGG-QDSLLVKIQVI-------- 1838
+G+ +V+ T + NL+ +++ A N G D L V VI
Sbjct: 30766 KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKP 30825
Query: 1839 AAP--PVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL-- 1894
AP P I + V W K P + G + Y + + K + T ++
Sbjct: 30826 GAPGKPTITAVTKDSCVVAW----KPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRE 30881
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSE-RRVVMLTMEERVTSPRIEAASQKRTEV 1953
+FS L I L R E + S SE + + + +P + + V
Sbjct: 30882 TVFSVKNL-IEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKE-ELRNLNV 30939
Query: 1954 NFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQ--QHRVGSWIHVYPNGSLFIGSVTEKDS 2011
+ L C TG PKP + W K ++ ++R+ + Y L I SVT+ D+
Sbjct: 30940 RYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGY--HQLIIASVTDDDA 30997
Query: 2012 GVYLCVARNKMGDDLILMHVSLRLK-PAKIDHKQYFR----KQVLHGKDFQVDCKASGSP 2066
VY A N+ G + SL ++ PAKI + L G+ + SG P
Sbjct: 30998 TVYQVRATNQGGS--VSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKP 31055
Query: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
P I+W + NN GH T ++ N V + G Y A+N G
Sbjct: 31056 DPVITWQKGQDLIDNN-------GHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 31108
Query: 2127 KDEMKVHLTV 2136
D+ V L V
Sbjct: 31109 IDQKTVELDV 31118
Score = 62.0 bits (149), Expect = 7e-09
Identities = 118/596 (19%), Positives = 217/596 (36%), Gaps = 83/596 (13%)
Query: 2061 KASGSPVPEISWSLPDGTMINNAMQ---ADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDY 2117
KA+G P P W+ DG I + ++D G L +K ++ G Y
Sbjct: 32874 KATGEPRPTAIWT-KDGKAITQGGKYKLSEDKG----------GFFLEIHKTDTSDSGLY 32922
Query: 2118 TCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL 2177
TC +N+ G LT+ Q T K E+T K + +
Sbjct: 32923 TCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKT----------SEITPQKKAVVQEEI 32972
Query: 2178 PSNDMISFSIDRYTFHANGSLTINKV--KLLDSGEYVCVARNPSGDDTKMYKLDVVSKPP 2235
+ S I + L + + K+L S E V ++ + K + ++K
Sbjct: 32973 SQKALRSEEIKMSEAKSQEKLALKEEASKVLISEE---VKKSAATSLEKSIVHEEITKTS 33029
Query: 2236 LINGLYTNRTVIKATAVRHS---KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITV 2292
+ IKA + + S + +A + +V W++ + Y ++
Sbjct: 33030 QASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVS- 33088
Query: 2293 HKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL---EMLRRPTFRNPFNEKIVA 2349
+ TL I+ D C+++ + E ++ Q ++ E+ P F + + +
Sbjct: 33089 GSDQTLTIKQASHRDEGILTCISKTK--EGIVKCQYDLTLSKELSDAPAFISQPRSQNIN 33146
Query: 2350 QLGKSTALNCSVDGNPPPEIIWILPN-------GTRFSNGPQSYQYLIASNGSFIISKTT 2402
+ G++ C + G P PEI W N S Y S I +
Sbjct: 33147 E-GQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVY--------SLEIRNAS 33197
Query: 2403 REDAGKYRCAARNKVGYIE---KLVILEIGQKP----VILTYAPGTVKG-ISGESLSLHC 2454
D+GKY A+N G L++L + ++P V+ T +++G S +S+ +
Sbjct: 33198 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSA 33257
Query: 2455 VSDGIPKPNIKWTMPSGYVVDR-PQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVG 2513
+ + S + ++ + + + V ++++ + + + ++S
Sbjct: 33258 SKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTS 33317
Query: 2514 HTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTA 2573
L I PP+I P I G + C G P PE+TW +
Sbjct: 33318 KML---KAGIRGIPPKI-EALPSDISIDEGKVLTVACAFTGEPTPEVTW---------SC 33364
Query: 2574 SKERTHGSEQ--LHLQGT-----LVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ H EQ H++ T L+I + Q D G+Y + N GSD A I +
Sbjct: 33365 GGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 61.6 bits (148), Expect = 1e-08
Identities = 56/187 (29%), Positives = 73/187 (39%), Gaps = 25/187 (13%)
Query: 489 VGGTVGLNCPGQGDPTPHVDW-----LLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
VG V L C G V W LL D ++ +V D L++ D
Sbjct: 6188 VGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFV--------DNVATLKILQTDL 6239
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQE-NGIHHTVFIGETLDLPCHSTGIPD 602
+G Y C +SN + R+T EP + + + V GE+ D CH TG
Sbjct: 6240 SHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQP 6299
Query: 603 ASISW------VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFL 656
I+W + PG N V N LRIL+V D G Y C A N G D
Sbjct: 6300 MRITWSKDNKEIRPGGNYTITC-----VGNTPHLRILKVGKGDSGQYTCQATNDVGKDMC 6354
Query: 657 IFQVSVK 663
Q+SVK
Sbjct: 6355 SAQLSVK 6361
Score = 59.7 bits (143), Expect = 4e-08
Identities = 160/824 (19%), Positives = 287/824 (34%), Gaps = 123/824 (14%)
Query: 1667 FLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSAS 1726
F+P + G P P + WT+ L +N+ L L I D G+++ +
Sbjct: 20797 FVPIK--GRPAPEVTWTKDNINLKNRANIENTESFTL----LIIPECNRYDTGKFVMTIE 20850
Query: 1727 NLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILAN--- 1783
N G V + V+ P +L R +IT + S T+ W L
Sbjct: 20851 NPAGKKSGFVNVRVLDTPGPVLNLRPTDIT---------------KDSVTLHWDLPLIDG 20895
Query: 1784 ----QTVVSESSQGSRQAVVTVDG-----TLVLHNLSIYDRGFYKCVASNPGG-----QD 1829
+ E + +R++ T T + LS F++ +A N G +
Sbjct: 20896 GSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTET 20955
Query: 1830 SLLVKIQVIAAPPV---ILEQRRQVIVGTW------GESLKLPCTAKGTPQPSVYWVLSD 1880
+ VK +PP I++ + + W G S + + S W +
Sbjct: 20956 TEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQW--TH 21013
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGS----ERRVVMLTMEE 1936
T VK L+ +RNL + T++ +A +S G E R V++ +
Sbjct: 21014 ITTVKGLECV-------------VRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQT 21060
Query: 1937 RVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVY 1996
+ + QK GD + + G PKP + W+ ++ Q RV ++
Sbjct: 21061 MLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWK-KGDQILKQTQRV-NFETTA 21118
Query: 1997 PNGSLFIGSVTEKDSGVYLCVARNKMGD--DLILMHV----SLRLKPAKIDHKQYFRKQV 2050
+ L I DSG Y ARN +G+ D+I + V P K D
Sbjct: 21119 TSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFD--------- 21169
Query: 2051 LHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSG---------HRTRRYTLFNN 2101
+ D PE +P + Q D + T + T
Sbjct: 21170 ----EVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTT 21225
Query: 2102 GTLY------FNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKA 2155
G Y N+ GV C N K +TA + + ++ +
Sbjct: 21226 GLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSD 21285
Query: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVA 2215
G + +L V + I W S ++ +I F ++G + E +
Sbjct: 21286 GGSPILGYHVERKERNGILWQTVSKALVPGNI----FKSSGLTDGIAYEFRVIAENMAGK 21341
Query: 2216 RNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIM 2275
PS M LD + P L R + ++ +K + + T +
Sbjct: 21342 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTV---TLKWAKPEYTGGFKITSYIVEKRDL 21398
Query: 2276 PDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG----ESVLVVQLEVL 2331
P+ +L A + S I ++ + + + +F +A+N G S +
Sbjct: 21399 PNGRWLKANF--SNILENE---FTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCR 21453
Query: 2332 EMLRRPTFR--NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL 2389
+ + P + F + ++ + G++ L V G PPP + W + G +
Sbjct: 21454 DDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEW--SKDGKELEGTAKLEIK 21511
Query: 2390 IASNGSFIISK-TTREDAGKYRCAARNKVGYIEKLVILEIGQKP 2432
IA + +++K +TR D+G Y A N G+ + + +++ +P
Sbjct: 21512 IADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRP 21555
Score = 59.3 bits (142), Expect = 5e-08
Identities = 46/179 (25%), Positives = 79/179 (44%), Gaps = 6/179 (3%)
Query: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG--SLTINKVKLLDSGEYVC 2213
G TA D +V G P P+ FW +++ + +G SL I DSGE+
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530
Query: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRH-SKKHFDCRAEGTPSPEVM 2272
VA+N +G + L V + + ++ + +K ++ S+ RA G P+P+++
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEK--LKNVNIKEGSRLEMKVRATGNPNPDIV 1588
Query: 2273 WIMPDNIFLTAPYYGSRITVHK-NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
W+ +I + Y RI K L+I + DSA + A N+ G ++ V
Sbjct: 1589 WLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Score = 59.3 bits (142), Expect = 5e-08
Identities = 66/269 (24%), Positives = 98/269 (36%), Gaps = 20/269 (7%)
Query: 2080 INNAMQADDSGHRTRRYTLFNNGTLYFNKV--GVAEEGDYTCYAQNTLGKDEMKVHLTVI 2137
+ + + DD +R + + + Y GV E DY C + T+ K + + +
Sbjct: 31628 VKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYC--RRTMKKIKRRTDTMRL 31685
Query: 2138 TAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDR-YTFHANG 2196
P NK G+ +T P+P + W + D+ YTF ++
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745
Query: 2197 SL---TINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYT---NRTVIKAT 2250
L TIN V D EY VARN G+D+ KL V PP + R + A
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAE 31805
Query: 2251 AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG----TLEIRNVRLS 2306
F+ R G P P + W P I + G L IR+
Sbjct: 31806 CQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGP----NIEIIHEGLDYYALHIRDTLPE 31861
Query: 2307 DSADFICVARNEGGESVLVVQLEVLEMLR 2335
D+ + A N G + L+V E LR
Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQV-ERLR 31889
Score = 57.4 bits (137), Expect = 2e-07
Identities = 144/657 (21%), Positives = 233/657 (35%), Gaps = 100/657 (15%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG---TLYIRNLASSDRG 1913
GE+ +L C G P P + W G E+ + K + S+G TL + D G
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRF-GKEL----IQSRKYKMSSDGRTHTLTVMTEEQEDEG 30601
Query: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVN--FGDKLLLNCSATGEPKP 1971
Y CIAT+ G L ++ +P+ + + G L L+ G P P
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQ---ATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVP 30658
Query: 1972 QIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD-SGVYLCVARNKMGDDLILMH 2030
+ W K + + ++ Y + L + +V K +G Y N G ++
Sbjct: 30659 AMTWFHGQKLLQNSENITIENTEHYTH--LVMKNVQRKTHAGKYKVQLSNVFGTVDAILD 30716
Query: 2031 VSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLP---DGTMINNAMQAD 2087
V ++ KP K ++ S V ISW P G+ I N +
Sbjct: 30717 VEIQDKPDKPTGP------------IVIEALLKNSAV--ISWKPPADDGGSWITNYVVEK 30762
Query: 2088 DSGHRTRRYTLFNNG--TLYFNKVGVAEEGDY--TCYAQNTLG-KDEMKVHLTVITAAPR 2142
+ L ++ V + E Y AQNT G D ++V VI +P
Sbjct: 30763 CEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPF 30822
Query: 2143 IRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSND----MISFSIDRYTFHANGSL 2198
+ I A VT D + W P++D + ++ +++ N +
Sbjct: 30823 EKPGAPGKPTITA---------VTKD-SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWI 30872
Query: 2199 ---------TINKVKLLDSG---EYVCVARNPSGD-------DTKMYKLDVVSKPPLING 2239
T+ VK L G E+ N G+ + K DV + P
Sbjct: 30873 SVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKE 30932
Query: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG--T 2297
N V S C+ G P P V W + A RI K G
Sbjct: 30933 ELRNLNVRY-----QSNATLVCKVTGHPKPIVKWYRQGKEII-ADGLKYRIQEFKGGYHQ 30986
Query: 2298 LEIRNVRLSDSADFICVARNEGGE--SVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKST 2355
L I +V D+ + A N+GG +++EV + P + A G+
Sbjct: 30987 LIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGA-VHALRGEVV 31045
Query: 2356 ALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFII--SKTTREDAGKYRCAA 2413
++ G P P I W +NG YQ ++ + + ++ + R+DAG Y A
Sbjct: 31046 SIKIPFSGKPDPVITWQKGQDLIDNNG--HYQVIVTRSFTSLVFPNGVERKDAGFYVVCA 31103
Query: 2414 RNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPS 2470
+N+ G +K V L++ P +G+ +S V N+ WT P+
Sbjct: 31104 KNRFGIDQKTVELDVAD-------VPDPPRGVKVSDVSRDSV-------NLTWTEPA 31146
Score = 57.0 bits (136), Expect = 2e-07
Identities = 53/188 (28%), Positives = 78/188 (41%), Gaps = 18/188 (9%)
Query: 1664 SDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG--TLSIQRVEIQDRGQY 1721
S+A L C+ G+P P + W R G ++ R+Q G L I V D Y
Sbjct: 30943 SNATLVCKVTGHPKPIVKWYR--QGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVY 31000
Query: 1722 LCSASN----LFGTDHLHVTLSVVSYPPRILERRTKEITVHS--GSTVELKCRAEGRPSP 1775
A+N + GT L V + + P+ LE VH+ G V +K G+P P
Sbjct: 31001 QVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMG---AVHALRGEVVSIKIPFSGKPDP 31057
Query: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVL--HNLSIYDRGFYKCVASNPGGQDSLLV 1833
+TW + + G Q +VT T ++ + + D GFY A N G D V
Sbjct: 31058 VITWQKGQDLI---DNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTV 31114
Query: 1834 KIQVIAAP 1841
++ V P
Sbjct: 31115 ELDVADVP 31122
Score = 56.6 bits (135), Expect = 3e-07
Identities = 204/985 (20%), Positives = 327/985 (33%), Gaps = 212/985 (21%)
Query: 1656 ASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV---LPNGTLSIQR 1712
+S+++ D + G P PTI WT+ GL L KQ +R+ V L TLSI+
Sbjct: 23237 SSYSVQVGQDLKIEVPISGRPKPTITWTK--DGLPL---KQTTRINVTDSLDLTTLSIKE 23291
Query: 1713 VEIQDRGQYLCSASNLFGTDHLHVTLSVVSY------PPRILERRTKEITV------HSG 1760
D GQY + +N+ G + + + P + + + IT+ ++G
Sbjct: 23292 THKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTG 23351
Query: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKC 1820
+ R + T W + + TV TL + L ++
Sbjct: 23352 GCQITNYIVQKRDTTTTVWDVVSATVART--------------TLKVTKLKTGTEYQFRI 23397
Query: 1821 VASNPGGQDSLLVKIQVIA----------APPVILEQRRQVIVGTWGESLKLPCTAKGTP 1870
A N GQ L ++A P + +V W E P G+P
Sbjct: 23398 FAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHE----PVNNGGSP 23453
Query: 1871 ----------QPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLY-IRNLASSDRGTYECIA 1919
+ S+ W + T + QF L G Y R A + G +
Sbjct: 23454 VIGYHLERKERNSILWTKVNKTIIHDTQFKAQNL---EEGIEYEFRVYAENIVG----VG 23506
Query: 1920 TSSTGSERRVVMLTME-----ERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIM 1974
+S SE V + E + R E Q V G ++ P
Sbjct: 23507 KASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGR 23566
Query: 1975 WRLPSKA-VVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG------DDLI 2027
W S V++ Q V +TE + +A+N G D
Sbjct: 23567 WMKASFTNVIETQFTVSG--------------LTEDQRYEFRVIAKNAAGAISKPSDSTG 23612
Query: 2028 LMHVSLRLKPAKIDHKQYFRKQVL--HGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQ 2085
+ ++ +I FR ++ G+ F+++ G P+P I W D +
Sbjct: 23613 PITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGD-------KE 23665
Query: 2086 ADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV--------- 2136
++S + T F + + + + + G Y A N G V++ V
Sbjct: 23666 IEESARCEIKNTDFKALLIVKDAIRI-DGGQYILRASNVAGSKSFPVNVKVLDRPGPPEG 23724
Query: 2137 ---ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFH 2193
+T + S + ++ G + + V ++ W + ++++++ S+
Sbjct: 23725 PVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSL------ 23778
Query: 2194 ANGSLTINKVKLLDSGEYV--CVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATA 2251
KLL+ EYV +A N G + V+ K P +
Sbjct: 23779 -------KVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFV-------------- 23817
Query: 2252 VRHSKKHFDCRAEGTPSPEVMWIMPDNI-------FLTAPYYGSRITVHKNGTLEIRNVR 2304
+ K + S V W PD+ ++ S I K I ++R
Sbjct: 23818 LPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLR 23877
Query: 2305 LSDSA-------DFICVARNEGG---ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
L + +F A N G S V + + + +P P N IV S
Sbjct: 23878 LRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPG--PPTNAHIVDTTKNS 23935
Query: 2355 TALNCS---VDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG----SFIISKTTREDAG 2407
L DG EI+ + + + +Q + G F ISK T
Sbjct: 23936 ITLAWGKPIYDGGS--EILGYVVEICKADE--EEWQIVTPQTGLRVTRFEISKLTEHQEY 23991
Query: 2408 KYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVK------------------GI---S 2446
K R A NKVG E T PGTVK GI +
Sbjct: 23992 KIRVCALNKVGLGEA-------------TSVPGTVKPEDKLEAPELDLDSELRKGIVVRA 24038
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYIC 2506
G S +H G P P I W+ G D+ QI K + + L I D G YI
Sbjct: 24039 GGSARIHIPFKGRPTPEITWSREEGEFTDKVQIE-KGVNYTQ--LSIDNCDRNDAGKYIL 24095
Query: 2507 KAQNSVG--HTLITVPVMIVAYPPR 2529
K +NS G +TV V+ PP+
Sbjct: 24096 KLENSSGSKSAFVTVKVLDTPGPPQ 24120
Score = 56.6 bits (135), Expect = 3e-07
Identities = 71/322 (22%), Positives = 118/322 (36%), Gaps = 52/322 (16%)
Query: 1853 VGTWGESLKLPCTAKGTPQPS-VYWVLSDGTEVKPLQFTNSKLFLFSNGT--LYIRNLAS 1909
VG G +K C + Q + V W V+ L+ + + +G LY++++
Sbjct: 31578 VGEEGGHVKYVCKIENYDQSTQVTWYFG----VRQLENSEKYEITYEDGVAILYVKDITK 31633
Query: 1910 SDRGTYECIATSSTGSER------------------RVVMLTMEERVTSPRIEAASQKRT 1951
D GTY C + G + R M ++ R + R+ + T
Sbjct: 31634 LDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFT 31693
Query: 1952 ------EVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV----DQQHRVGSWIHVYPNGSL 2001
G+ + + T P+P + W + + D+++ S +Y L
Sbjct: 31694 LPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY---QL 31750
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDH--KQYFRK-----QVLHGK 2054
I SVT D Y VARNK G+D +++ L P D + F++ + G+
Sbjct: 31751 TINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQ 31810
Query: 2055 DFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
+ + SG P P + W DG ++ + Y L TL +
Sbjct: 31811 SVCFEIRVSGIPPPTLKWE-KDGQPLSLGPNIEIIHEGLDYYALHIRDTL------PEDT 31863
Query: 2115 GDYTCYAQNTLGKDEMKVHLTV 2136
G Y A NT G + HL V
Sbjct: 31864 GYYRVTATNTAGSTSCQAHLQV 31885
Score = 56.2 bits (134), Expect = 4e-07
Identities = 123/558 (22%), Positives = 211/558 (37%), Gaps = 83/558 (14%)
Query: 2112 AEEGDYTCYAQNTLG-----KDEMKVHLTVITA-APRIRQSNKTNKRIKAGDTAVLDCEV 2165
A E ++ +A+N G + M + + + AP IR+ K + K G+ A L C++
Sbjct: 30498 ATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMK-DVTTKLGEAAQLSCQI 30556
Query: 2166 TGDPKPKIFWLLPSNDMISFSIDRYTFHANG---SLTINKVKLLDSGEYVCVARNPSGDD 2222
G P P I W ++I +Y ++G +LT+ + D G Y C+A N G+
Sbjct: 30557 VGRPLPDIKWYRFGKELIQSR--KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEV 30614
Query: 2223 TKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLT 2282
KL + + P G A S G P P + W +
Sbjct: 30615 ETSSKLLLQATPQFHPGYPLKEKYYGAVG---STLRLHVMYIGRPVPAMTWFHGQKLLQN 30671
Query: 2283 APYYGSRITVHKNGTLEIRNV-RLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRN 2341
+ T H L ++NV R + + + N G ++ +E+ + +PT
Sbjct: 30672 SENITIENTEHYT-HLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPT--- 30727
Query: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEI--IWILPNGTRFSNGPQSYQYLIASNGSFIIS 2399
++ L K++A+ + PP + WI + ++ + S+ IS
Sbjct: 30728 --GPIVIEALLKNSAV---ISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSA---IS 30779
Query: 2400 KTT------REDAGKY-RCAARNKVGYIEKLVI--LEIGQKPVILTYAPG--TVKGISGE 2448
TT E+AG Y R +A+N G + L + + I + P APG T+ ++ +
Sbjct: 30780 VTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKD 30839
Query: 2449 SLSLHCVSDGIPKPNIKWTMPSG---------YVVDRPQINGKYILHDNGTLVIKEATAY 2499
S CV + W P+ Y+ R + K+I T I+E T +
Sbjct: 30840 S----CV--------VAWKPPASDGGAKIRNYYLEKREKKQNKWI--SVTTEEIRE-TVF 30884
Query: 2500 DRGNYI--------CKAQNSVGHT-------LITVPVMIVAYPPRITNRPPRSIVTRTGA 2544
N I K +N G + IT + P R++ R +
Sbjct: 30885 SVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHF-KEELRNLNVRYQS 30943
Query: 2545 AFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYK 2604
L C G PKP + W +++ K R + + Q L+I + D+ +Y+
Sbjct: 30944 NATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQ--LIIASVTDDDATVYQ 31001
Query: 2605 CTAKNPLGSDYAATYIQV 2622
A N GS ++V
Sbjct: 31002 VRATNQGGSVSGTASLEV 31019
Score = 55.5 bits (132), Expect = 7e-07
Identities = 120/528 (22%), Positives = 194/528 (36%), Gaps = 79/528 (14%)
Query: 2104 LYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDT--AVL 2161
L + ++ G+YT +G+ E K L V T KT K I+ +T A
Sbjct: 2851 LMLQNISPSDAGEYTA----VVGQLECKAKLFVETL-----HITKTMKNIEVPETKTASF 2901
Query: 2162 DCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSL---TINKVKLLDSGEYVCVARNP 2218
+CEV+ P + WL N + +++ G L I DS EY V N
Sbjct: 2902 ECEVSHFNVPSM-WL--KNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGND 2958
Query: 2219 SGDDT-KMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPD 2277
T + + + S IN + + T EG W+ +
Sbjct: 2959 QVSATLTVTPIMITSMLKDINAEEKDTITFEVTV----------NYEGI---SYKWLK-N 3004
Query: 2278 NIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRP 2337
+ + + T +L IRNV D+AD+ VA + L V+ +E
Sbjct: 3005 GVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIE----- 3059
Query: 2338 TFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWI-----LPNGTRFSNGPQSYQYLIAS 2392
FR + V + K C V P + W+ L R + Y + +
Sbjct: 3060 -FRKHIKDIKVLE-KKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYVHRL-- 3114
Query: 2393 NGSFIISKTTREDAGKYRCAARNKVGYIEKLV------ILEIGQKPVILTYAPGTVK-GI 2445
+I T DAGKY A V + V I I ++ ++ V+ +
Sbjct: 3115 ----LIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEV 3170
Query: 2446 SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505
+ + + H DGI + N + YVV+R +H + I E D G Y
Sbjct: 3171 NEDDVDAHWYKDGI-EINFQVQERHKYVVERR-------IH---RMFISETRQSDAGEYT 3219
Query: 2506 CKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMP 2565
A G +V + + A P + + + ++G + V G P+P+I+W
Sbjct: 3220 FVA----GRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISW-YK 3274
Query: 2566 DHSLLSTASK-ERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
+ LLST K + H ++ TL++ D+ +Y C AKN G
Sbjct: 3275 EEQLLSTGFKCKFLHDGQEY----TLLLIEAFPEDAAVYTCEAKNDYG 3318
Score = 54.7 bits (130), Expect = 1e-06
Identities = 48/174 (27%), Positives = 72/174 (41%), Gaps = 11/174 (6%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV G L C G P W DG ++ A S+ I+K L++ A+ D
Sbjct: 6655 TVTTGNPFALECVVTGTPELSAKWF-KDGRELSAD--SKHHITFINKVASLKIPCAEMSD 6711
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVE-AYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G+Y N T + V + +V ++ +G ++ L C +G S
Sbjct: 6712 KGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPIS 6771
Query: 605 ISWVIPGNNVLY----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
+ W GN ++ QSS + V TL + + P D G Y CVAAN +G D
Sbjct: 6772 VGWFQDGNEIVSGPKCQSSFSENVC---TLNLSLLEPSDTGIYTCVAANVAGSD 6822
Score = 53.1 bits (126), Expect = 3e-06
Identities = 52/180 (28%), Positives = 79/180 (43%), Gaps = 17/180 (9%)
Query: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSI 1812
+ + V GST + G P P V+W Q + + + G + + L + ++
Sbjct: 13 QSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTK 72
Query: 1813 YDRGFYKCVASNPGGQDS----LLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKG 1868
+ G Y A+N GQ + LLVK + APP + QR Q + G ++L G
Sbjct: 73 ANSGRYSLKATNGSGQATSTAELLVKAE--TAPPNFV-QRLQSMTVRQGSQVRLQVRVTG 129
Query: 1869 TPQPSVYWVLSDGTEVK-PLQFTNSKLFLFSNGTLYIRNLASS---DRGTYECIATSSTG 1924
P P V + DG E++ L F S+ G LY +A + D GTY AT+S G
Sbjct: 130 IPTPVVKF-YRDGAEIQSSLDFQISQ-----EGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Score = 53.1 bits (126), Expect = 3e-06
Identities = 109/522 (20%), Positives = 179/522 (34%), Gaps = 98/522 (18%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLD---SG 2209
I+AG VLD V G P+PKI W ++ ++ + G +K D SG
Sbjct: 29059 IRAGSDLVLDAAVGGKPEPKIIWTKGDKELDL--CEKVSLQYTGKRATAVIKFCDRSDSG 29116
Query: 2210 EYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGT--- 2266
+Y +N SG + V+ P L +R + + S D AE T
Sbjct: 29117 KYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYI 29176
Query: 2267 ----PSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGES 2322
+ + W++ + T Y +R+ + +R V N+ G
Sbjct: 29177 VERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAV-------------NKYGPG 29223
Query: 2323 VLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNG 2382
V V E ++ R +F P I ++G G I W P G
Sbjct: 29224 VPV---ESEPIVARNSFTIPSPPGIPEEVGT---------GKEHIIIQWTKPES---DGG 29268
Query: 2383 PQSYQYLIAS-----------NGSFIISKTTREDAG-------KYRCAARNKVGYIEKLV 2424
+ YL+ N +++ T + ++R A N G E
Sbjct: 29269 NEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSE 29328
Query: 2425 ILEI--GQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPS--------GYVV 2474
++P +Y PG + H +S + WT P GYV+
Sbjct: 29329 ASNFISCREP---SYTPGPPSAPRVVDTTKHSIS-------LAWTKPMYDGGTDIVGYVL 29378
Query: 2475 DRPQINGK--YILHDNGTLVIKEATAYD-----RGNYICKAQNSVGHTLITV------PV 2521
+ + + Y +H N T+ E T D + ++ A N G + + PV
Sbjct: 29379 EMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPV 29438
Query: 2522 MIVAYPP-RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHG 2580
+ P + + +++ R GA+ +L G P P ITW L S A + T
Sbjct: 29439 ERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTES 29498
Query: 2581 SEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
L++ D+G Y A+N G A ++V
Sbjct: 29499 ------YSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKV 29534
Score = 52.8 bits (125), Expect = 5e-06
Identities = 51/207 (24%), Positives = 86/207 (41%), Gaps = 20/207 (9%)
Query: 2426 LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYIL 2485
LE KPV + P + K + G++ G P P W +V+ K ++
Sbjct: 1451 LERLYKPVFVL-KPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVN--DYTHKVVI 1507
Query: 2486 HDNGT--LVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITN---RPPRSIVT 2540
++GT L+I AT D G + AQN G + I+V + + A ++ +++
Sbjct: 1508 KEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNI 1567
Query: 2541 RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT-----LVIQNP 2595
+ G+ ++ A G P P+I W L + H ++ ++GT L I +
Sbjct: 1568 KEGSRLEMKVRATGNPNPDIVW-------LKNSDIIVPHKYPKIRIEGTKGEAALKIDST 1620
Query: 2596 QTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ DS Y TA N G D + V
Sbjct: 1621 VSQDSAWYTATAINKAGRDTTRCKVNV 1647
Score = 52.8 bits (125), Expect = 5e-06
Identities = 51/209 (24%), Positives = 80/209 (38%), Gaps = 13/209 (6%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVR-APYVSEDGRILIDKSGKLELQMADSFDTG 547
VG V +C G V W DG ++ +P V +D + L + D G
Sbjct: 8070 VGLPVVFDCAISGSEPISVSWY-KDGKPLKDSPNVQTS---FLDNTATLNIFKTDRSLAG 8125
Query: 548 VYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHT-VFIGETLDLPCHSTGIPDASIS 606
Y C ++N + + R+ + E + + + +GE+ D CH TG +S
Sbjct: 8126 QYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVS 8185
Query: 607 WVIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK 665
W + L N L +L+V D G Y C A N G D Q+++K +
Sbjct: 8186 WAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKER 8245
Query: 666 ------GQRPLEHDGETEGSGLDESNPIA 688
+R E ETEG+ +A
Sbjct: 8246 LIPPSFTKRLSETVEETEGNSFKLEGRVA 8274
Score = 52.8 bits (125), Expect = 5e-06
Identities = 51/193 (26%), Positives = 82/193 (42%), Gaps = 21/193 (10%)
Query: 1666 AFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSA 1725
A L C+ VG PLP I W R G +L + ++ TL++ E +D G Y C A
Sbjct: 30550 AQLSCQIVGRPLPDIKWYRF--GKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 30607
Query: 1726 SNLFGTDHLHVTLSVVSYPPRILERRTKEITVHS-GSTVELKCRAEGRPSPTVTWILANQ 1784
+N G L + + P KE + GST+ L GRP P +TW +
Sbjct: 30608 TNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK 30667
Query: 1785 TVVSESSQGSRQAVVTVDGT-----LVLHNLSIYDR-GFYKCVASNPGGQDSLLVKIQVI 1838
+ + + +T++ T LV+ N+ G YK SN G ++ +++
Sbjct: 30668 LLQNSEN-------ITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 30720
Query: 1839 AAP-----PVILE 1846
P P+++E
Sbjct: 30721 DKPDKPTGPIVIE 30733
Score = 52.0 bits (123), Expect = 8e-06
Identities = 46/204 (22%), Positives = 87/204 (42%), Gaps = 25/204 (12%)
Query: 1876 WVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSER-RVVMLTM 1934
W S+ +K QFT I L + + A + TG R R +++
Sbjct: 30477 WKKSNKERIKDKQFT-------------IGGLLEATEYEFRVFAENETGLSRPRRTAMSI 30523
Query: 1935 EERVTSPRIEAASQKRTEVN--FGDKLLLNCSATGEPKPQIMW-RLPSKAVVDQQHRVGS 1991
+ ++TS ++ +V G+ L+C G P P I W R + + +++++ S
Sbjct: 30524 KTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSS 30583
Query: 1992 WIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVL 2051
+ +L + + ++D GVY C+A N++G+ + L L+ H Y K+
Sbjct: 30584 DGRTH---TLTVMTEEQEDEGVYTCIATNEVGE--VETSSKLLLQATPQFHPGYPLKEKY 30638
Query: 2052 H---GKDFQVDCKASGSPVPEISW 2072
+ G ++ G PVP ++W
Sbjct: 30639 YGAVGSTLRLHVMYIGRPVPAMTW 30662
Score = 51.6 bits (122), Expect = 1e-05
Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 8/167 (4%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
L G +V + C G P V W +G+++ + + L D + L + M + D+G
Sbjct: 7694 LSGSSVVMECKVYGSPPISVSWF-HEGNEISSGRKYQT--TLTDNTCALTVNMLEESDSG 7750
Query: 548 VYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
Y CI++N +D + +TV EP ++ + V G + G P S+SW
Sbjct: 7751 DYTCIATNMAGSDECSAPLTVREP--PSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSW 7808
Query: 608 VIPGNNVLYQSSRDKKVLNNGT--LRILQVTPKDQGYYRCVAANPSG 652
G++ L R L + L + V G Y C+ +N +G
Sbjct: 7809 -FKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAG 7854
Score = 51.6 bits (122), Expect = 1e-05
Identities = 184/904 (20%), Positives = 320/904 (35%), Gaps = 146/904 (16%)
Query: 1653 GKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT---LS 1709
GK +T + L CE P + W + D + K + + +G L
Sbjct: 12022 GKLQDYTGVEKDEVILQCEISKADAP-VKWFK-----DGKEIKPSKNAVIKADGKKRMLI 12075
Query: 1710 IQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRA 1769
+++ D GQY C GTD L + +++ +HS +E + A
Sbjct: 12076 LKKALKSDIGQYTCDC----GTDKTSGKLDIEDREIKLVR------PLHSVEVMETET-A 12124
Query: 1770 EGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG---TLVLHNLSIYDRGFYKCVASNPG 1826
+ I AN + E+ + + +G +LVLHN + G A+N
Sbjct: 12125 RFETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVK 12184
Query: 1827 GQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKP 1886
L VK +VI +L + V V T GE+ C P V W L G +++P
Sbjct: 12185 SSAHLRVKPRVIG----LLRPLKDVTV-TAGETATFDCELSYEDIP-VEWYLK-GKKLEP 12237
Query: 1887 LQFTNSKLFLFSNG---TLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRI 1943
+ K+ S G TL +R++ D G + A V P +
Sbjct: 12238 ----SDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF--------VKEPPV 12285
Query: 1944 EAASQKRTE-VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF 2002
E + V G +L C + E ++ ++ + +++ + + V L
Sbjct: 12286 EFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRV---RKLV 12342
Query: 2003 IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK----QVLHGKDFQV 2058
I T +D Y C A++ +L + P H ++ R QV + +
Sbjct: 12343 IHDCTPEDIKTYTCDAKD------FKTSCNLNVVP---PHVEFLRPLTDLQVREKEMARF 12393
Query: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGT---LYFNKVGVAEEG 2115
+C+ S ++ W DG I + ++Y + + G L NK + +E
Sbjct: 12394 ECELSRENA-KVKW-FKDGAEIK----------KGKKYDIISKGAVRILVINKCLLDDEA 12441
Query: 2116 DYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFW 2175
+Y+C + + + + N N + DT L CEV+ P ++ W
Sbjct: 12442 EYSCEVRTARTSG-----MLTVLEEEAVFTKNLANIEVSETDTIKLVCEVS-KPGAEVIW 12495
Query: 2176 LLPSNDMISFSIDRYTFHANGS---LTINKVKLLDSGEYVC-VARNPSGDDTKMYKL--D 2229
++I RY G L I L D+G Y C + + + K+++L +
Sbjct: 12496 YKGDEEII--ETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAE 12553
Query: 2230 VVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
+SKP N +++ K F C P V W D + Y
Sbjct: 12554 FISKP-------QNLEILEG-----EKAEFVCSISKESFP-VQWKRDDKTLESGDKY-DV 12599
Query: 2290 ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVA 2349
I K L +++ L D ++ + G + L V+E LR P + V
Sbjct: 12600 IADGKKRVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVV---PLKDTRVK 12652
Query: 2350 QLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG---SFIISKTTREDA 2406
+ + NC V+ + W F S +Y+I + I +D
Sbjct: 12653 E-QQEVVFNCEVN-TEGAKAKWFRNEEAIF----DSSKYIILQKDLVYTLRIRDAHLDDQ 12706
Query: 2407 GKYRCAARNKVG-YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIK 2465
Y + N G ++ L + ++ + + ++ + +S++ C + + +K
Sbjct: 12707 ANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRL-NVTLK 12765
Query: 2466 WTMPSGYVVDRPQINGKYILHDNGT----------LVIKEATAYDRGNYICKA--QNSVG 2513
WT NG+ + DN L IK+ D G YI A SV
Sbjct: 12766 WTK-----------NGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVA 12814
Query: 2514 HTLI 2517
LI
Sbjct: 12815 ELLI 12818
Score = 51.6 bits (122), Expect = 1e-05
Identities = 36/126 (28%), Positives = 54/126 (42%), Gaps = 3/126 (2%)
Query: 2310 DFICVARNEGGESVLVVQLEVL--EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPP 2367
+F +NEGGES V EV+ E L++P + + + G + L V G P P
Sbjct: 18172 EFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFP 18231
Query: 2368 EIIWILP-NGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVIL 2426
E+ W + T + P+ A + F ++K R D GKY A N G +
Sbjct: 18232 EVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATV 18291
Query: 2427 EIGQKP 2432
+ KP
Sbjct: 18292 NVLDKP 18297
Score = 51.6 bits (122), Expect = 1e-05
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 4/98 (4%)
Query: 1744 PPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG 1803
PP+IL ++IT+ +G + ++ G+P PT W VV+ S +A
Sbjct: 18899 PPKIL--MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKA--DSSS 18954
Query: 1804 TLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
L++ +++ D G+Y A N G D+ +K+ V+ AP
Sbjct: 18955 ILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAP 18992
Score = 51.2 bits (121), Expect = 1e-05
Identities = 50/174 (28%), Positives = 74/174 (42%), Gaps = 9/174 (5%)
Query: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILI-DKSGKLELQMADSFDTGVYHC 551
V L C D V W DG K+ +D +I DK LE+ +A D+G Y C
Sbjct: 3661 VHLECQVDEDRKVTVTWS-KDGQKLPP---GKDYKICFEDKIATLEIPLAKLKDSGTYVC 3716
Query: 552 ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPG 611
+SN + + +TV EP ++ + + GE+ L C G P ++W
Sbjct: 3717 TASNEAGSSSCSATVTVREP-PSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTW-FKN 3774
Query: 612 NNVLYQSS--RDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
N L +S+ R V + L I V +D G Y C A N G D ++ +K
Sbjct: 3775 NKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIK 3828
Score = 50.4 bits (119), Expect = 2e-05
Identities = 49/170 (28%), Positives = 69/170 (40%), Gaps = 9/170 (5%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRI-LIDKSGKLELQMADSF 544
TV+ G L +G V WL +R SE+ RI ++ L+ A+
Sbjct: 5620 TVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRE---SENIRITFVENVATLQFAKAEPA 5676
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
+ G Y C N + V+EP V + + TV +GET L C G P+ S
Sbjct: 5677 NAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPM--TVTVGETCTLECKVAGTPELS 5734
Query: 605 ISWVIPGNNVLYQSSRDKKVLNN--GTLRILQVTPKDQGYYRCVAANPSG 652
+ W G +L S + K N +LRIL V +D G Y N G
Sbjct: 5735 VEWYKDG-KLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVG 5783
Score = 50.4 bits (119), Expect = 2e-05
Identities = 37/124 (29%), Positives = 54/124 (43%), Gaps = 5/124 (4%)
Query: 531 DKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGET 590
+KS LE+ + D G Y+C N D + +I ++EP Q + V +G++
Sbjct: 7920 EKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPV--KVSVGDS 7977
Query: 591 LDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNN--GTLRILQVTPKDQGYYRCVAA 648
L C G P+ +SW G+ L ++ K N TL QV D G Y C A
Sbjct: 7978 ASLQCQLAGTPEIGVSW-YKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAE 8036
Query: 649 NPSG 652
N G
Sbjct: 8037 NSVG 8040
Score = 50.4 bits (119), Expect = 2e-05
Identities = 40/133 (30%), Positives = 60/133 (45%), Gaps = 4/133 (3%)
Query: 536 LELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVE-AYQENGIHHTVFIGETLDLP 594
L+++ A D G+Y C SN + + T I + EP + ++ TV GE + L
Sbjct: 8307 LQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLS 8366
Query: 595 CHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGT--LRILQVTPKDQGYYRCVAANPSG 652
CH G I W+ G + S R +GT L + V D G Y C A+N +G
Sbjct: 8367 CHVQGSEPIRIQWLKAGREIK-PSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAG 8425
Query: 653 VDFLIFQVSVKMK 665
D +V++K K
Sbjct: 8426 SDTTKSKVTIKDK 8438
Score = 50.4 bits (119), Expect = 2e-05
Identities = 138/670 (20%), Positives = 239/670 (35%), Gaps = 120/670 (17%)
Query: 1935 EERVTSPRIEAASQKRTEVNFGD--KLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW 1992
E+R+ P IE + R V L L G P P++ W +D+ +
Sbjct: 21852 EDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTS 21911
Query: 1993 IHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH 2052
+ L +G+V DSG Y+ N G ++V + P
Sbjct: 21912 SYTL----LIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP--------------- 21952
Query: 2053 GKDFQVDCKASGSPVPEISWSLP---DGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKV 2109
G + K ++W P G+ I N + R T+ N KV
Sbjct: 21953 GPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKV 22012
Query: 2110 GVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKR-IKAGDTAVLDCEVTGD 2168
+EG Y L ++E + L TA +S K ++R + G ++D VT +
Sbjct: 22013 DQLQEG--CSYYFRVLAENEYGIGLPAETA-----ESVKASERPLPPGKITLMD--VTRN 22063
Query: 2169 PKPKIFWLLPSND----MISFSIDRYTFHANGSLTINKVKLLDS-------GE---YVCV 2214
+ W P +D ++ + ++ T ++ T VK+ ++ GE +
Sbjct: 22064 -SVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVS 22122
Query: 2215 ARNPSG-DDTKMYKLDVVSK----PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSP 2269
A+N G D + + V++K PP L+ TV+ ++ D G P+P
Sbjct: 22123 AQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLK-----VDVPFIGRPTP 22177
Query: 2270 EVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
V W DN+ L + + N L I++ D ++ N GE++ + +
Sbjct: 22178 AVTW-HKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVI 22236
Query: 2330 VLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL 2389
VL+ PT P ++ + TA + ++ PP ++ G Y+
Sbjct: 22237 VLDKPGPPT--GP------VKMDEVTADSITLSWGPP-----------KYDGGSSINNYI 22277
Query: 2390 IASNG---------SFIISKTT----REDAG---KYRCAARNKVGYIEKLVILEIGQKPV 2433
+ S +++TT R G ++R AA N+ G L +P
Sbjct: 22278 VEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYL-----NSEPT 22332
Query: 2434 ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP--------SGYVVDRPQINGKYIL 2485
+ Y P V G G + D + ++W P GY ++R + N +
Sbjct: 22333 VAQY-PFKVPGPPGTPVVTLSSRDSM---EVQWNEPISDGGSRVIGYHLERKERNSILWV 22388
Query: 2486 HDNGTLVIK---EATAYDRG---NYICKAQN--SVGHTLITVPVMIVAYPPRITNRPPRS 2537
N T + + + T + G + A+N +G + P RP
Sbjct: 22389 KLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI 22448
Query: 2538 IVTRTGAAFQ 2547
IVTR Q
Sbjct: 22449 IVTRNSVTLQ 22458
Score = 50.1 bits (118), Expect = 3e-05
Identities = 49/182 (26%), Positives = 70/182 (38%), Gaps = 13/182 (7%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAP--YVSEDGRILIDKSGKLELQMADSF 544
VL G V L QG + W + V Y++++ LEL + +
Sbjct: 4217 VLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEAL-----ESSLELYLVKTS 4271
Query: 545 DTGVYHCISSNYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
D+G Y C SN + + V EP VE + + + G+ L C TG P
Sbjct: 4272 DSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKK---GDATQLACKVTGTPP 4328
Query: 603 ASISWVIPGNNVLYQSS-RDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVS 661
I+W + S R V + LR+ V +D G Y C A N +G D V
Sbjct: 4329 IKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVI 4388
Query: 662 VK 663
VK
Sbjct: 4389 VK 4390
Score = 50.1 bits (118), Expect = 3e-05
Identities = 79/352 (22%), Positives = 125/352 (35%), Gaps = 61/352 (17%)
Query: 2316 RNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS---TALNCSVDG-NPPPEIIW 2371
R++ G SV V++ +E+ P + +I+ +G+ C ++ + ++ W
Sbjct: 31550 RSQKGVSVAKVKVASIEI-------GPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTW 31602
Query: 2372 ILPNGTRFSNGPQSYQYLIASNGSFIISKT-TREDAGKYRCAARNKVGYIEKLVILEI-G 2429
G R + Y+ + + K T+ D G YRC N G L + G
Sbjct: 31603 YF--GVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKG 31660
Query: 2430 QKPVILTYAPGTVKGIS--------------------------GESLSLHCVSDGIPKPN 2463
+ V Y T+K I GE++ P+P+
Sbjct: 31661 VREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPH 31720
Query: 2464 IKWTMPSGYVVDRPQINGKYILH-DNGT--LVIKEATAYDRGNYICKAQNSVGHTLITVP 2520
+ W SG + + KY D G L I T D Y A+N G
Sbjct: 31721 VTW-YKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 31779
Query: 2521 VMIVAYPPRI--TNRP--PRSIVTRTGAAFQLHCVAL---GVPKPEITWEMPDHSLLSTA 2573
+ + +PP T RP R + Q C + G+P P + WE L
Sbjct: 31780 LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGP 31839
Query: 2574 SKERTHGSEQ---LHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
+ E H LH++ TL D+G Y+ TA N GS ++QV
Sbjct: 31840 NIEIIHEGLDYYALHIRDTL------PEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 49.7 bits (117), Expect = 4e-05
Identities = 45/170 (26%), Positives = 61/170 (35%), Gaps = 6/170 (3%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS-GKLELQMADSFD 545
V +G C Q P W A R Y S+ I K LE+ D
Sbjct: 3467 VALGHLAKFTCEIQSAPNVRFQWFKAG----REIYESDKCSIRSSKYISSLEILRTQVVD 3522
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G Y C +SN + T +TV E + T F+G+ C TG P
Sbjct: 3523 CGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIET 3582
Query: 606 SWVIPGNNVLYQSS-RDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
W G + + R N L + +T +D+G Y C A+N G D
Sbjct: 3583 IWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGAD 3632
Score = 49.7 bits (117), Expect = 4e-05
Identities = 178/866 (20%), Positives = 311/866 (35%), Gaps = 142/866 (16%)
Query: 1697 NSRVQVLPNGT---LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSY--PPRILERR 1751
+ R +++ +GT + I+ +D +Y+ A + + L + + + P + + +
Sbjct: 11882 DDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDVTAK 11941
Query: 1752 TKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLS 1811
KE V TVEL + V W +Q + + S + T ++ +LS
Sbjct: 11942 EKESAVF---TVELS-----HDNIRVKWFKNDQRLHTTRSVSMQDEGKT--HSITFKDLS 11991
Query: 1812 IYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQ 1871
I D + A + K+ V+ P + Q G + + L C
Sbjct: 11992 IDDTSQIRVEAMGMSSE----AKLTVLEGDPYFTG-KLQDYTGVEKDEVILQCEISKADA 12046
Query: 1872 PSVYWVLSDGTEVKPLQFTNSKLFLFSNGT---LYIRNLASSDRGTYECIATSSTGSERR 1928
P V W DG E+KP + + ++G L ++ SD G Y C G+++
Sbjct: 12047 P-VKW-FKDGKEIKP----SKNAVIKADGKKRMLILKKALKSDIGQYTC----DCGTDKT 12096
Query: 1929 VVMLTMEER---VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV-- 1983
L +E+R + P + F ++ E W+L +A++
Sbjct: 12097 SGKLDIEDREIKLVRPLHSVEVMETETARFETEI-------SEDDIHANWKLKGEALLQT 12149
Query: 1984 -DQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDH 2042
D + + IH SL + + +G A N + LR+KP I
Sbjct: 12150 PDCEIKEEGKIH-----SLVLHNCRLDQTGGVDFQAAN------VKSSAHLRVKPRVIGL 12198
Query: 2043 KQYFRK-QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNN 2101
+ + V G+ DC+ S +P + W L + + S + TL
Sbjct: 12199 LRPLKDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGKVHTLTL--- 12254
Query: 2102 GTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKT-NKRIKAGDTAV 2160
V + + G+ A+ + K H + P + + ++ ++ G TAV
Sbjct: 12255 -----RDVKLEDAGEVQLTAK------DFKTHANLFVKEPPVEFTKPLEDQTVEEGATAV 12303
Query: 2161 LDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG---SLTINKVKLLDSGEYVCVARN 2217
L+CEV+ + K+ W +++ +Y A+G L I+ D Y C A+
Sbjct: 12304 LECEVSRE-NAKVKWFKNGTEILKSK--KYEIVADGRVRKLVIHDCTPEDIKTYTCDAK- 12359
Query: 2218 PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPD 2277
D L+VV PP + L R + F+C + +V W D
Sbjct: 12360 ---DFKTSCNLNVV--PPHVEFL---RPLTDLQVREKEMARFECEL-SRENAKVKW-FKD 12409
Query: 2278 NIFLTAPYYGSRITVHKNGT---LEIRNVRLSDSADFIC---VARNEGGESVLVVQLEVL 2331
+ G + + G L I L D A++ C AR G +VL +
Sbjct: 12410 GAEIKK---GKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFT 12466
Query: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIA 2391
+ L K+V ++ K P E+IW + G +Y I
Sbjct: 12467 KNLANIEVSETDTIKLVCEVSK-----------PGAEVIWYKGDEEIIETG----RYEIL 12511
Query: 2392 SNGS---FIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGE 2448
+ G +I EDAG Y C + K+ + E+ + P ++ + GE
Sbjct: 12512 TEGRKRILVIQNAHLEDAGNYNCRLPSS-RTDGKVKVHELAAE---FISKPQNLEILEGE 12567
Query: 2449 SLSLHCVSDGIPKPNIKW-----TMPSGYVVDRPQINGKYILHDNG---TLVIKEATAYD 2500
C P ++W T+ SG KY + +G LV+K+AT D
Sbjct: 12568 KAEFVCSISKESFP-VQWKRDDKTLESG---------DKYDVIADGKKRVLVVKDATLQD 12617
Query: 2501 RGNYICK--AQNSVGHTLITVPVMIV 2524
G Y+ A + H + + IV
Sbjct: 12618 MGTYVVMVGAARAAAHLTVIEKLRIV 12643
Score = 49.7 bits (117), Expect = 4e-05
Identities = 137/626 (21%), Positives = 211/626 (33%), Gaps = 139/626 (22%)
Query: 1883 EVKPLQFTNSKLFLFSNGTLYIRNL----ASSDRGTYE-------CIATSSTGSERRVVM 1931
E KP+ +L N T+ N A S+ TYE S GSE
Sbjct: 28976 ERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSES-TGP 29034
Query: 1932 LTMEERVTSPRIEAASQKRTE---VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHR 1988
+T + P+ E ++ + + G L+L+ + G+P+P+I+W K + D +
Sbjct: 29035 VTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL-DLCEK 29093
Query: 1989 VGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK 2048
V S + + I DSG Y +N G + + V + P R
Sbjct: 29094 V-SLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRV 29152
Query: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
Q C ++WSLP +D G Y + T N
Sbjct: 29153 T-------QEKCT--------LAWSLPQ----------EDGGAEITHYIVERRETSRLNW 29187
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGD 2168
V V E Y L K+ + R+R NK + ++
Sbjct: 29188 VIVEGECPTLSYVVTRLIKNNEYIF--------RVRAVNKYGPGVPVESEPIVARNSFTI 29239
Query: 2169 PKPK--------------IFWLLPS----NDMISFSIDRYTFHANGSLTINKVKLLDSGE 2210
P P I W P N++ ++ +D+ + +NK +
Sbjct: 29240 PSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNK-------D 29292
Query: 2211 YVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK-----KHFDCR--- 2262
YV DT+ L V S L+ G V A +S+ CR
Sbjct: 29293 YVVY-------DTR---LKVTS---LMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPS 29339
Query: 2263 -AEGTPS-PEVMWIMPDNIFL--TAPYY--GSRIT----------------VHKNGTLE- 2299
G PS P V+ +I L T P Y G+ I VH N T+
Sbjct: 29340 YTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRN 29399
Query: 2300 ----IRNVRLSDSADFICVARNEGGESVL---VVQLEVLEMLRRPTFR--NPFNEKIVAQ 2350
+ ++++ F A N G S + ++E +E + P + + + +
Sbjct: 29400 TEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIR 29459
Query: 2351 LGKSTALNCSVDGNPPPEIIWILPNGTRFSNG----PQSYQYLIASNGSFIISKTTREDA 2406
G S L SV G PPP I W S +SY LI + K R DA
Sbjct: 29460 AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLI-------VDKVNRYDA 29512
Query: 2407 GKYRCAARNKVGYIEKLVILEIGQKP 2432
GKY A N+ G V++++ P
Sbjct: 29513 GKYTIEAENQSGKKSATVLVKVYDTP 29538
Score = 49.3 bits (116), Expect = 5e-05
Identities = 46/187 (24%), Positives = 74/187 (39%), Gaps = 25/187 (13%)
Query: 489 VGGTVGLNCPGQGDPTPHVDW-----LLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
+G V C G V W LL D + ++ +V L++ D
Sbjct: 7129 LGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHN--------VATLQILQTDQ 7180
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQE-NGIHHTVFIGETLDLPCHSTGIPD 602
G Y+C +SN + ++ + E V + + + + +GE+ CH TG
Sbjct: 7181 SHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAP 7240
Query: 603 ASISW------VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFL 656
I+W + PG N + V N TL +L+V D G Y C A+N +G D
Sbjct: 7241 IKITWAKDNREIRPGGNY-----KMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSC 7295
Query: 657 IFQVSVK 663
Q+ V+
Sbjct: 7296 SAQLGVQ 7302
Score = 49.3 bits (116), Expect = 5e-05
Identities = 81/401 (20%), Positives = 144/401 (35%), Gaps = 85/401 (21%)
Query: 2264 EGTPSPEVMWIMPD-NIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGES 2322
+G P+P +W PD N+ L A + T TL + N +D+ + N G
Sbjct: 28382 QGRPTPTAVWSKPDSNLSLRADIH----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSK 28437
Query: 2323 VLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNG 2382
+ ++VL+ P P K V + G +T ++W P G
Sbjct: 28438 SITFTVKVLDTPGPP---GPITFKDVTR-GSAT-------------LMWDAP---LLDGG 28477
Query: 2383 PQSYQYLI----ASNGSF-IISKTTREDAGKYRCAARNKVGYIEKLVILEIG-------Q 2430
+ + Y++ AS S+ +IS+ K A Y + E G
Sbjct: 28478 ARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMP 28537
Query: 2431 KPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP--------SGYVVDRPQINGK 2482
+P++ T P + L V + W P +GY+++ Q
Sbjct: 28538 EPIVATEQPAPPR-------RLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSD 28590
Query: 2483 YILHDNGTLVIK-------EATAYDRGNYICKAQNSVGHT-------LITVPVMIVAYPP 2528
+ + T + E T Y+ + KA+N G++ + + +
Sbjct: 28591 FWVEAGHTKQLTFTVERLVEKTEYE---FRVKAKNDAGYSEPREAFSSVIIKEPQIEPTA 28647
Query: 2529 RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLS------TASKERTHGSE 2582
+T + I + G+ F + G P P++TW++ + L T +K+RT
Sbjct: 28648 DLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRT---- 28703
Query: 2583 QLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
TL +++ DSG Y T +N G + + VI
Sbjct: 28704 ------TLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI 28738
Score = 48.9 bits (115), Expect = 7e-05
Identities = 50/196 (25%), Positives = 76/196 (38%), Gaps = 17/196 (8%)
Query: 2337 PTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG-- 2394
PTF P +V + G + + G P PE+ W +G S + S+G
Sbjct: 6 PTFTQPLQSVVVLE-GSTATFEAHISGFPVPEVSWFR-DGQVISTSTLPGVQISFSDGRA 63
Query: 2395 SFIISKTTREDAGKYRCAARNKVGYI----EKLVILEIGQKPVILTYAPGTVKGISGESL 2450
I T+ ++G+Y A N G E LV E + TV+ G +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVR--QGSQV 121
Query: 2451 SLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG---TLVIKEATAYDRGNYICK 2507
L GIP P +K+ + Q + + + G +L+I EA D G Y
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEI----QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVN 177
Query: 2508 AQNSVGHTLITVPVMI 2523
A NSVG T +++
Sbjct: 178 ATNSVGRATSTAELLV 193
Score = 48.9 bits (115), Expect = 7e-05
Identities = 52/210 (24%), Positives = 74/210 (35%), Gaps = 11/210 (5%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS---GKLELQMAD 542
+ +VG V L +G V W G VR E I I S L+ +
Sbjct: 7502 STVVGKEVQLQTTIEGAEPISVVWFKDKGEIVR-----ESDNIWISYSENIATLQFSRVE 7556
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
+ G Y C N ++V+EP + I T G+T L C G P+
Sbjct: 7557 PANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTT--GDTCTLECTVAGTPE 7614
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVAANPSGVDFLIFQVS 661
S W G + + N + L+I+ V P D G Y NP G D +
Sbjct: 7615 LSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQ 7674
Query: 662 VKMKGQRPLEHDGETEGSGLDESNPIAHLK 691
V + P E +GL S+ + K
Sbjct: 7675 VSDRTVPPSFTRKLKETNGLSGSSVVMECK 7704
Score = 48.9 bits (115), Expect = 7e-05
Identities = 90/437 (20%), Positives = 166/437 (37%), Gaps = 57/437 (13%)
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQR-RQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
PG ++ + +P + L+ R IV G +++ G P P+V W +++ T
Sbjct: 16506 PGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTL 16565
Query: 1884 VKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVM---LTMEERVTS 1940
+ + + + ++ I+N S +G Y +A + G ++ ++ L + V +
Sbjct: 16566 PQEATIETTAI----SSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGT 16621
Query: 1941 P----RIEAASQKRT---EVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWI 1993
P + S K T + G + N + W + V Q V I
Sbjct: 16622 PFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLI 16681
Query: 1994 HVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMH-VSLRLKPAKIDHKQYFRKQVLH 2052
+ F E G+ V + + L++ +++ +P ++ K+ + V
Sbjct: 16682 Q---GKAYFFRIAAENSIGMGPFV---ETSEALVIREPITVPERPEDLEVKEVTKNTVT- 16734
Query: 2053 GKDFQVDCKASGSPVPEISWSLP--DG--TMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
++W+ P DG +IN +++ G T ++ N L K
Sbjct: 16735 -----------------LTWNPPKYDGGSEIINYVLESRLIG--TEKFHKVTNDNLLSRK 16775
Query: 2109 VGVA--EEGD---YTCYAQNTLGKDEMKVHLTVIT-----AAPRIRQSNKTNKRIKAGDT 2158
V +EGD Y A N +G+ + IT A P + + I+ G+
Sbjct: 16776 YTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEA 16835
Query: 2159 AVLDCEVTGDPKPKIFWLLPSNDMISFSIDRY-TFHANGSLTINKVKLLDSGEYVCVARN 2217
L +G PKPK+ W D++ T A +L K K DSG+Y V N
Sbjct: 16836 FALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVEN 16895
Query: 2218 PSGDDTKMYKLDVVSKP 2234
+G +++VV +P
Sbjct: 16896 STGSRKGFCQVNVVDRP 16912
Score = 48.5 bits (114), Expect = 9e-05
Identities = 49/170 (28%), Positives = 69/170 (40%), Gaps = 8/170 (4%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
VL G V +G P V+W V+ + D +LEL D +
Sbjct: 5904 VLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNI---YFEDTVAELELFNIDISQS 5960
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C+ SN T R+ V EP A+ + H+V G+++ L TG S++
Sbjct: 5961 GEYTCVVSNNAGQASCTTRLFVKEP--AAFLKRLSDHSVEPGKSIILESTYTGTLPISVT 6018
Query: 607 WVIPGNNVLYQSSRDKKVLNNGT--LRILQVTPKDQGYYRCVAANPSGVD 654
W G N+ S + V T L IL T +D G Y C N +G D
Sbjct: 6019 WKKDGFNIT-TSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 6067
Score = 48.5 bits (114), Expect = 9e-05
Identities = 38/166 (22%), Positives = 67/166 (40%), Gaps = 6/166 (3%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
++G +V L C G V W V P + L L + + DTG
Sbjct: 6753 ILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSS---FSENVCTLNLSLLEPSDTG 6809
Query: 548 VYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
+Y C+++N +D + +TV EP ++++ V G +L G P + W
Sbjct: 6810 IYTCVAANVAGSDECSAVLTVQEP--PSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKW 6867
Query: 608 VIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVAANPSG 652
++ S + + + T L + +V P + G Y C+ N +G
Sbjct: 6868 FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAG 6913
Score = 48.1 bits (113), Expect = 1e-04
Identities = 88/399 (22%), Positives = 144/399 (36%), Gaps = 48/399 (12%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYV 2212
++AG L V G P PK+ W D + L I DSG+Y
Sbjct: 18618 VRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYS 18677
Query: 2213 CVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFD-CRAEGTPSPEV 2271
NP+G+ + V+ P ++ L K + V + H E +V
Sbjct: 18678 LTLVNPAGEKAVFVNVRVLDTPGPVSDL-------KVSDVTKTSCHVSWAPPENDGGSQV 18730
Query: 2272 MWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLV-VQLEV 2330
+ + + + K + + N+ + F A NE G V V V
Sbjct: 18731 THYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPV 18790
Query: 2331 L--EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILP---NGTRFSNGPQS 2385
L + L P +P + V ++ K++A + W+ P G + S
Sbjct: 18791 LASDPLSEP---DPPRKLEVTEMTKNSAT-----------LAWLPPLRDGGAKIDGYITS 18836
Query: 2386 Y-----------QYLIASNGSFIISKTTREDAGKYRCAARNKVGYI---EKLVILEIGQK 2431
Y +Y + + S +++ K+R AARN VG E + E ++
Sbjct: 18837 YREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQ 18896
Query: 2432 ---PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDN 2488
P IL T+K +G+ L + G P P KW VV + + +
Sbjct: 18897 LLPPKILMPEQITIK--AGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHL-AVHKADSS 18953
Query: 2489 GTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYP 2527
L+IK+ T D G Y A+NS G + V+++ P
Sbjct: 18954 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAP 18992
Score = 48.1 bits (113), Expect = 1e-04
Identities = 119/545 (21%), Positives = 194/545 (35%), Gaps = 76/545 (13%)
Query: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
G + +D G P+P +SW DGT++ A + R N TL V
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWK-KDGTLLKPAEGIKMAMQR-------NLCTLELFSVNRK 19361
Query: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPK 2172
+ GDYT A+N+ G + L V+ P S K NK D A+L E +
Sbjct: 19362 DSGDYTITAENSSGSKSATIKLKVLD-KPGPPASVKINKMY--SDRAMLSWEPPLED--- 19415
Query: 2173 IFWLLPSNDMISFSID-RYTFHANGSLTINKV--------KLLDSGEY---VCVARNPSG 2220
+++ ++ +D R T N + V KL++ EY +C A N G
Sbjct: 19416 -----GGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRIC-AENKYG 19469
Query: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
++ ++K P + VI H + A+ SP +++
Sbjct: 19470 VGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRET 19529
Query: 2281 LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF- 2339
+ TL+ ++ +F A N+ G R P +
Sbjct: 19530 QAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPG-KPSDASKAAYARDPQYP 19588
Query: 2340 -RNPFNEKIVAQLGKSTALNC---SVDGNPPPEIIWILPNGTRFS-------NGPQSYQY 2388
P K+ S +L+ + DG P II L R N PQ+ Q
Sbjct: 19589 PGPPAFPKVYDTTRSSVSLSWGKPAYDGGSP--IIGYLVEVKRADSDNWVRCNLPQNLQ- 19645
Query: 2389 LIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPG-------- 2440
F ++ + ++R A NK+GY + + + IL G
Sbjct: 19646 ----KTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRK 19701
Query: 2441 TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD 2500
T+ +G ++ L+ G P P I W+ P+ + DR ++ K D L + YD
Sbjct: 19702 TLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDT-FLRCENVNKYD 19760
Query: 2501 RGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEI 2560
G YI +NS G T+ V ++ P PP ++ + + +
Sbjct: 19761 AGKYILTLENSCGKKEYTIVVKVLDTP-----GPPVNVTVK----------EISKDSAYV 19805
Query: 2561 TWEMP 2565
TWE P
Sbjct: 19806 TWEPP 19810
Score = 48.1 bits (113), Expect = 1e-04
Identities = 64/267 (23%), Positives = 107/267 (40%), Gaps = 24/267 (8%)
Query: 2288 SRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL----EMLRRPTFRNPF 2343
+ IT K +RN+ + F +A N G S V+ ML R +
Sbjct: 21012 THITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIY 21071
Query: 2344 NEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI-ISKTT 2402
+ ++A+ G + + V G P P + W G + Q + + + + I++
Sbjct: 21072 QKLVIAKAGDNIKVEIPVLGRPKPTVTW--KKGDQILKQTQRVNFETTATSTILNINECV 21129
Query: 2403 REDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKG-ISGESLSLHCVSDGIPK 2461
R D+G Y ARN VG + ++ +++ PG G I + +S V+
Sbjct: 21130 RSDSGPYPLTARNIVGEVGDVITIQVHD-------IPGPPTGPIKFDEVSSDFVTFSWDP 21182
Query: 2462 PNIKWTMP-SGYVVDRPQINGKYILHDNGTLVIK---EATAYDRG---NYICKAQNSVG- 2513
P +P S YVV+ Q + + + T VI+ +AT G + KAQN G
Sbjct: 21183 PENDGGVPISNYVVEMRQTDSTTWV-ELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGV 21241
Query: 2514 HTLITVPVMIVAYPPRITNRPPRSIVT 2540
IT ++ YP ++ P VT
Sbjct: 21242 GPGITSACIVANYPFKVPGPPGTPQVT 21268
Score = 47.8 bits (112), Expect = 1e-04
Identities = 48/177 (27%), Positives = 66/177 (37%), Gaps = 6/177 (3%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
VL G V +G P V W V + L D +LEL D+ +
Sbjct: 7786 VLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVS---LEDSVAELELFDVDTSQS 7842
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y CI SN T + + P + N +++ G+ L L TG P S++
Sbjct: 7843 GEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLND--YSIEKGKPLILEGTFTGTPPISVT 7900
Query: 607 WVIPGNNVL-YQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
W G NV Q + L I T +D G Y C N SG D Q+ +
Sbjct: 7901 WKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILI 7957
Score = 47.4 bits (111), Expect = 2e-04
Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 9/164 (5%)
Query: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK-NGTLEIRNVRLSDSADFICVARN 2317
F+ G P PEV W + T+ G +I+ L I V ++S + A N
Sbjct: 25 FEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATN 84
Query: 2318 EGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGT 2377
G++ +L V P F V Q G L V G P P ++ +G
Sbjct: 85 GSGQATSTAELLVKAETAPPNFVQRLQSMTVRQ-GSQVRLQVRVTGIPTP-VVKFYRDGA 142
Query: 2378 RFSNGPQSYQYLIASNG---SFIISKTTREDAGKYRCAARNKVG 2418
+ S + I+ G S +I++ ED+G Y A N VG
Sbjct: 143 EIQS---SLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Score = 47.4 bits (111), Expect = 2e-04
Identities = 55/191 (28%), Positives = 79/191 (41%), Gaps = 12/191 (6%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRI-LIDKSGKLELQMADSFD 545
VL G ++ +G P V W GS+ P E I L D +LEL +
Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKWF--KGSRELVP--GESCNISLEDFVTELELFEVQPLE 6900
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
+G Y C+ +N + T + V EP + + +V G + L TG P S+
Sbjct: 6901 SGDYSCLVTNDAGSASCTTHLFVKEPAT--FVKRLADFSVETGSPIVLEATYTGTPPISV 6958
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGT--LRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
SW I ++ QS R + + L IL+ T +D Y C+ N +G D VSV
Sbjct: 6959 SW-IKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVL 7017
Query: 664 MKGQ--RPLEH 672
PLEH
Sbjct: 7018 EPPYFIEPLEH 7028
Score = 47.4 bits (111), Expect = 2e-04
Identities = 47/173 (27%), Positives = 68/173 (39%), Gaps = 12/173 (6%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILI---DKSGKLELQM 540
+ +V G + L G P V W+ + +S+ R I +KS LE+
Sbjct: 6935 DFSVETGSPIVLEATYTGTPPISVSWIKDEY------LISQSERCSITMTEKSTILEILE 6988
Query: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
+ D Y C+ N DI ++V+EP + E H IGE L C G
Sbjct: 6989 STIEDYAQYSCLIENEAGQDICEALVSVLEP--PYFIEPLEHVEAVIGEPATLQCKVDGT 7046
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNN-GTLRILQVTPKDQGYYRCVAANPSG 652
P+ ISW + + + NN +L I +V D G Y C A N G
Sbjct: 7047 PEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVG 7099
Score = 47.4 bits (111), Expect = 2e-04
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 4/108 (3%)
Query: 1736 VTLSVVSYPPRI-LERRTKEI-TVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQG 1793
VT+ + PPRI L K + TV +G+ V L G+P PTV+W + + ++G
Sbjct: 19284 VTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSW--KKDGTLLKPAEG 19341
Query: 1794 SRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
+ A+ TL L +++ D G Y A N G S +K++V+ P
Sbjct: 19342 IKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 47.0 bits (110), Expect = 2e-04
Identities = 57/220 (25%), Positives = 85/220 (38%), Gaps = 12/220 (5%)
Query: 1744 PPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG 1803
PP ER T S T++ K SP +I+ + + + +
Sbjct: 15294 PPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTS 15353
Query: 1804 TLVLHNLSIYDRGFYKCVASNPGGQDS----LLVKIQVIAAPPVI---LEQRRQVIVGTW 1856
LV NL + ++ A N G+ L V IQ PP I L R I
Sbjct: 15354 FLV-ENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 15412
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKP---LQFTNSKLFLFSNGT-LYIRNLASSDR 1912
GE + +P G P P + W ++ KP LQ T ++ T L I D+
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 15472
Query: 1913 GTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTE 1952
GTY A++ GS R V + + +R + PR A + + E
Sbjct: 15473 GTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAE 15512
Score = 47.0 bits (110), Expect = 2e-04
Identities = 80/407 (19%), Positives = 148/407 (36%), Gaps = 49/407 (12%)
Query: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSI 1812
K + V +G + L GRP+P VTW + + + + +V LV+ N +
Sbjct: 18614 KLVIVRAGCPIRLFAIVRGRPAPKVTW---RKVGIDNVVRKGQVDLVDTMAFLVIPNSTR 18670
Query: 1813 YDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQP 1872
D G Y NP G+ ++ V ++V+ P + + + + T P G Q
Sbjct: 18671 DDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQV 18730
Query: 1873 SVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVML 1932
+ Y V + K ++ + ++ NL + + A + G V
Sbjct: 18731 THYIVEKREADRKTWSTVTPEV---KKTSFHVTNLVPGNEYYFRVTAVNEYGPG---VPT 18784
Query: 1933 TMEERV--TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSK---AVVD--- 1984
+ + V + P E ++ EV + SAT + W P + A +D
Sbjct: 18785 DVPKPVLASDPLSEPDPPRKLEVT----EMTKNSAT------LAWLPPLRDGGAKIDGYI 18834
Query: 1985 -----QQHRVGSWIH--VYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLI-----LMHVS 2032
++ W V + SL + + E + ARN +G L +
Sbjct: 18835 TSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAK 18894
Query: 2033 LRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHR 2092
+L P KI + + GK +++ G P P W + ++ ++ A
Sbjct: 18895 EQLLPPKILMPEQI--TIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKAD- 18951
Query: 2093 TRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA 2139
++ L V + G Y+ A+N+ G D K+ + V+ A
Sbjct: 18952 -------SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 18991
Score = 47.0 bits (110), Expect = 2e-04
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 16/119 (13%)
Query: 2141 PRIRQS--NKTNKRIKAGDTAVLDCEVTGDPKPKIFW-----LLPSNDMISFSIDRYTFH 2193
PRI S K+ +KAG LD V G P P + W LL + I ++ R
Sbjct: 19293 PRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC- 19351
Query: 2194 ANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKP-----PLINGLYTNRTVI 2247
+L + V DSG+Y A N SG + KL V+ KP IN +Y++R ++
Sbjct: 19352 ---TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAML 19407
Score = 47.0 bits (110), Expect = 2e-04
Identities = 32/89 (35%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 2148 KTNKRIKAGDTAVLDC-EVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS-LTINKVKL 2205
K IKAGDT VL+ + G P PK W D+ I + T S LTI
Sbjct: 20385 KDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATR 20444
Query: 2206 LDSGEYVCVARNPSGDDTKMYKLDVVSKP 2234
D+GEY A NP G + K+ V+ P
Sbjct: 20445 KDAGEYTITATNPFGTKVEHVKVTVLDVP 20473
Score = 46.6 bits (109), Expect = 3e-04
Identities = 81/401 (20%), Positives = 143/401 (35%), Gaps = 57/401 (14%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYV 2212
I+AG + L + G P P++ W ++ +I T SL ++ V DSG+Y
Sbjct: 22954 IRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFT-SLVLDNVNRYDSGKYT 23012
Query: 2213 CVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVM 2272
N SG + + V+ P L + ++ D ++
Sbjct: 23013 LTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLD------GGSKIK 23066
Query: 2273 WIMPDNIFLTAPYYGSRIT-VHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL 2331
+ + T Y + +T HKN + +I ++ S F A NE G + + +
Sbjct: 23067 NYIVEKREATRKSYAAVVTNCHKN-SWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPI 23125
Query: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIA 2391
++ P P + V + +++ + W P G + QY++
Sbjct: 23126 KVAEVP---QPPGKITVDDVTRNSV-----------SLSWTKPE---HDGGSKIIQYIVE 23168
Query: 2392 SNGSF---------------IISKTTREDAGKYRCAARNKVG----------YIEKLVIL 2426
+I+ T+ + +R A N+ G + K +++
Sbjct: 23169 MQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVI 23228
Query: 2427 EIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILH 2486
E KP +Y+ G+ L + G PKP I WT + +IN L
Sbjct: 23229 EPDVKPAFSSYSVQV-----GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSL- 23282
Query: 2487 DNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYP 2527
D TL IKE D G Y N VG ++ ++ + P
Sbjct: 23283 DLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 46.6 bits (109), Expect = 3e-04
Identities = 197/938 (21%), Positives = 329/938 (35%), Gaps = 171/938 (18%)
Query: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
V+ G ++ E R P W+ A+ T V E+ TV G L+ R
Sbjct: 23545 VYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQ-------FTVSG------LTEDQRY 23591
Query: 1817 FYKCVASNPGGQDSL-------LVKIQVIAAPPVILEQR-RQVIVGTWGESLKLPCTAKG 1868
++ +A N G S + + P + ++ + R IV GE+ +L G
Sbjct: 23592 EFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHG 23651
Query: 1869 TPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERR 1928
P P++ W+ D E++ K F L +++ D G Y A++ GS+
Sbjct: 23652 KPLPTIEWLRGD-KEIEESARCEIKNTDFK-ALLIVKDAIRIDGGQYILRASNVAGSKSF 23709
Query: 1929 VVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHR 1988
V + + +R P T CS T P Q S VV+++
Sbjct: 23710 PVNVKVLDRPGPPEGPVQVTGVTSEK--------CSLTWSPPLQDGGSDISHYVVEKRET 23761
Query: 1989 VG-SWIHVYPN---GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQ 2044
+W V SL + + E + V+ +A NK G V L+ A + K
Sbjct: 23762 SRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYG-------VGEPLESAPVLMKN 23814
Query: 2045 YFRKQVLHGKDFQVDCKASGSPVPEISWSLPD---GTMINNAM--QADDSGHRTRRYTLF 2099
F VL G ++ + W+ PD G+ I + + D SG R +
Sbjct: 23815 PF---VLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKR 23871
Query: 2100 NNGTLYFNKVGVAEEGDYT--CYAQNTLGKDEMKVHLTVITAA-PRIRQSNKTN------ 2150
L G+ E+ +Y A+N G E A P + TN
Sbjct: 23872 RITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDT 23931
Query: 2151 ----------KRIKAGDTAVLDCEVTGDPKPKIFWLLPSND----MISFSIDRYTFHANG 2196
K I G + +L V + W + + + F I + T H
Sbjct: 23932 TKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEY 23991
Query: 2197 SLTINKVKLLDSGEYVCVARNPSGDDT-KMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
+ + + + GE V +D + +LD+ S+ L G+ V++A
Sbjct: 23992 KIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSE--LRKGI-----VVRAGGSARI 24044
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT---LEIRNVRLSDSADFI 2312
F +G P+PE+ W + F ++ + K L I N +D+ +I
Sbjct: 24045 HIPF----KGRPTPEITWSREEGEFT------DKVQIEKGVNYTQLSIDNCDRNDAGKYI 24094
Query: 2313 CVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIW- 2371
N G V ++VL+ P V ++ K +A ++W
Sbjct: 24095 LKLENSSGSKSAFVTVKVLDT------PGPPQNLAVKEVRKDSAF-----------LVWE 24137
Query: 2372 --ILPNGTRFSN--------GPQSYQYLIA--SNGSFIISKTTREDAGKYRCAARNKVGY 2419
I+ G + N ++Y + + S SF + T +R A N+ G
Sbjct: 24138 PPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGV 24197
Query: 2420 ---IEKLVILEIGQKPVILTYAPG--TVKGISGESLSLHCVSDGIPKPNIKWTMPS---- 2470
+E + ++ + P PG T+ +S S SL W P
Sbjct: 24198 GVPVETVDAVKAAEPPS----PPGKVTLTDVSQTSASL------------MWEKPEHDGG 24241
Query: 2471 ----GYVVD-RPQINGKYILHDNGTLVIKEATAYDRGN---YICKAQNSVGHT---LITV 2519
GYVV+ +P+ K+ + + T G + KA N G + ++ V
Sbjct: 24242 SRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGV 24301
Query: 2520 PVMI--VAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLST--ASK 2575
PV+ + P + P + + G ++ +G P+P I+W L T +
Sbjct: 24302 PVIAKDLTIQPSL-KLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNV 24360
Query: 2576 ERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
E T S LH I+ D G Y TA N G+
Sbjct: 24361 EETATSTVLH------IKEGNKDDFGKYTVTATNSAGT 24392
Score = 46.6 bits (109), Expect = 3e-04
Identities = 82/383 (21%), Positives = 140/383 (36%), Gaps = 51/383 (13%)
Query: 2265 GTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVL 2324
G P P V+W PD T Y T +L I N +DS + +N + L
Sbjct: 26212 GRPVPNVLWSKPDTDLRTRAYVD---TTDSRTSLTIENANRNDSGKYTLTIQNVLSAASL 26268
Query: 2325 VVQLEVLEMLRRPT---FRNPFNEKIVAQL------GKSTALNCSVDGNPPPEIIWILPN 2375
+ ++VL+ PT ++ E V G + N ++ + W+
Sbjct: 26269 TLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVT 26328
Query: 2376 GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYI--------EKLVILE 2427
+ SY+ G+ + + E+ A K G EKL +
Sbjct: 26329 N---NCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS 26385
Query: 2428 IGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHD 2487
I + V LT+ G S +H V + + K W + ++G
Sbjct: 26386 ISKDSVSLTWLKPEH---DGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSG------ 26436
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHT---LITVPVMIVAY--PPRIT--NRPPRSIVT 2540
++E + Y + A+N G + + +PV+I PP I N P ++
Sbjct: 26437 -----LRENSEYF---FRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYV 26488
Query: 2541 RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDS 2600
R G+ ++ G P P++T L +T +E L T+ ++ T+D+
Sbjct: 26489 RAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL----TINLKESVTADA 26544
Query: 2601 GIYKCTAKNPLGSDYAATYIQVI 2623
G Y+ TA N G+ A I V+
Sbjct: 26545 GRYEITAANSSGTTKAFINIVVL 26567
Score = 46.6 bits (109), Expect = 3e-04
Identities = 178/881 (20%), Positives = 299/881 (33%), Gaps = 130/881 (14%)
Query: 1659 TIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDR 1718
TI A SD L G P P I WT+ LDL ++ S T I+ + D
Sbjct: 29058 TIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKV--SLQYTGKRATAVIKFCDRSDS 29115
Query: 1719 GQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVT 1778
G+Y + N GT + V + V+ P + +T + KC T+
Sbjct: 29116 GKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVT-------QEKC--------TLA 29160
Query: 1779 WILANQT-------VVSESSQGSRQAVVTVDG-----TLVLHNLSIYDRGFYKCVASNPG 1826
W L + + E + SR V V+G + V+ L + ++ A N
Sbjct: 29161 WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKY 29220
Query: 1827 GQDSLLVKIQVIA-------APPVILEQRRQVIVGTWGESLKLPCT---AKGTPQPSVYW 1876
G + ++A +PP I E+ VGT E + + T + G + S Y
Sbjct: 29221 GPGVPVESEPIVARNSFTIPSPPGIPEE-----VGTGKEHIIIQWTKPESDGGNEISNY- 29274
Query: 1877 VLSDGTEVKPLQFTN-SKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTME 1935
L D E K L++T +K ++ + L + +L + A ++ G+
Sbjct: 29275 -LVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSE-------- 29325
Query: 1936 ERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP---------SKAVVDQQ 1986
S S + G T + + W P + Q+
Sbjct: 29326 ---PSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQE 29382
Query: 1987 HRVGSWIHVYPNGSLFIGSVTEKDSGV-----YLCVARNKMG-----DDLILMHVSLRLK 2036
W V+ N ++ T D + + A N G + + + R++
Sbjct: 29383 KDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIE 29442
Query: 2037 PAKIDHKQYFRKQVL--HGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTR 2094
++ +K V G ++ SG P P I+WS Q D R
Sbjct: 29443 IPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWS----------KQGIDLASRAI 29492
Query: 2095 RYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIK 2154
T + L +KV + G YT A+N GK V L + P S K + +
Sbjct: 29493 IDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATV-LVKVYDTPGPCPSVKVKEVSR 29551
Query: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCV 2214
T + P +++ + + T S T+ ++ L G
Sbjct: 29552 DSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVT--TKCSKTLYRISGLVEGTMYYF 29609
Query: 2215 ARNPS-----GDDTKMYKLDVVSKPPLINGLYTNRTVIKAT-AVRHSKKHFDCRAEGTPS 2268
P G+ + +VS+ PL+ V K+T + K +D + T
Sbjct: 29610 RVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLT-- 29667
Query: 2269 PEVMWIMPDNIFLTAPYYGS----RITVHKNGTLEIRNVRLSDSADFI--CVARNEGG-- 2320
L A G+ ++ K LE L++ ++ A+NE G
Sbjct: 29668 ---------GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVS 29718
Query: 2321 ---ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGT 2377
E+V V ++ L +L + I G+ L + G PPP W G+
Sbjct: 29719 EPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFA-GS 29777
Query: 2378 RFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTY 2437
+ + I +TT D G+Y +N G + + VI+
Sbjct: 29778 KLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETI-------KVIILD 29830
Query: 2438 APGTVKG-ISGESLSLHCVSDGIPKPNIKWTMP-SGYVVDR 2476
PG G I + + ++ P + P SGYVV++
Sbjct: 29831 KPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 29871
Score = 46.6 bits (109), Expect = 3e-04
Identities = 75/360 (20%), Positives = 139/360 (38%), Gaps = 69/360 (19%)
Query: 1558 VKSQNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTK 1617
+ ++NS PSP + I + KPE + G +E + + D +K+ +
Sbjct: 29231 IVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPE-----SDGGNEISNYLVDKREKKSLR 29285
Query: 1618 KSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPC-EAVGNP 1676
+ +K V T K+ Y F R+ AA + P+ + F+ C E P
Sbjct: 29286 WTRVNKDYVVYDTRLKVTSLMEGCDYQF---RVTAVNAAGNSEPSEASNFISCREPSYTP 29342
Query: 1677 LP--------------TIHWTR---------VPSGLDLSKRKQNSRVQVLPNGTL----- 1708
P ++ WT+ V L++ ++ + +V N T+
Sbjct: 29343 GPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEF 29402
Query: 1709 SIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRI-------LERRTKEITVHSGS 1761
++ +++ + + +A N+ G +++ + RI + K +T+ +G+
Sbjct: 29403 TVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGA 29462
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQG----SRQAVVTVD--GTLVLHNLSIYDR 1815
++ L GRP P +TW S QG SR + T + L++ ++ YD
Sbjct: 29463 SLRLMVSVSGRPPPVITW----------SKQGIDLASRAIIDTTESYSLLIVDKVNRYDA 29512
Query: 1816 GFYKCVASNPGGQDSLLVKIQVIAAP-----PVILEQRRQVIVGTWGESLKLPCTAKGTP 1870
G Y A N G+ S V ++V P + E R + TW ++P G P
Sbjct: 29513 GKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITW----EIPTIDGGAP 29568
Score = 46.2 bits (108), Expect = 4e-04
Identities = 106/544 (19%), Positives = 185/544 (34%), Gaps = 103/544 (18%)
Query: 1550 TPMPALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSD 1609
T P+ T V+++ + L P+A+ +K + + K K+ VS+ TT
Sbjct: 863 TVKPSETRVRAEPTPLPQFPFADTPDTYKSEAGVEVK-KEVGVSITGTT----------- 910
Query: 1610 WDGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLP 1669
++ F+ +EA ++ + P +V G + T+ L
Sbjct: 911 ------VREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSG-LKNVTVIEGESVTLE 963
Query: 1670 CEAVGNPLPTIHWTR----VPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSA 1725
C G P PT+ W R + S +D Q+ + L I+ +D G++ CSA
Sbjct: 964 CHISGYPSPTVTWYREDYQIESSIDFQITFQSGIAR------LMIREAFAEDSGRFTCSA 1017
Query: 1726 SNLFGT-----------------DHLHVTLSVVSYPPRILERRTKEITVHS--------- 1759
N GT + VT + R +E R +T S
Sbjct: 1018 VNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPG 1077
Query: 1760 ------------------GSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTV 1801
G +V C+ G P P V W + + + T
Sbjct: 1078 EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1137
Query: 1802 DGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVI----VGTWG 1857
+ LV+ D G Y V N G+ S + A ++++ +++++ V +
Sbjct: 1138 ECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFV 1197
Query: 1858 ESLKLPCTAKG-----------TPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRN 1906
+ K+ TA G Q + ++ T V + + + S I+
Sbjct: 1198 QEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKE 1257
Query: 1907 LASSDRGTYECIATS------STGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLL 1960
+ Y I T+ G E+ V ++ E V S R G +
Sbjct: 1258 I------EYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMG--VT 1309
Query: 1961 LNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARN 2020
+C +G P P+I W K + + ++ SL I V +D G+Y A N
Sbjct: 1310 FHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQ-DGRASLRIPVVLPEDEGIYTAFASN 1368
Query: 2021 KMGD 2024
G+
Sbjct: 1369 IKGN 1372
Score = 46.2 bits (108), Expect = 4e-04
Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 4/87 (4%)
Query: 1755 ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYD 1814
I VH+G + + G+P PTVTW + +T+ E++ + ++V+ N
Sbjct: 16534 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEAT----IETTAISSSMVIKNCQRSH 16589
Query: 1815 RGFYKCVASNPGGQDSLLVKIQVIAAP 1841
+G Y +A N G+ + + V+ P
Sbjct: 16590 QGVYSLLAKNEAGERKKTIIVDVLDVP 16616
Score = 46.2 bits (108), Expect = 4e-04
Identities = 61/260 (23%), Positives = 92/260 (35%), Gaps = 51/260 (19%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPP--------------------RI 1747
L ++ + D G Y C N +G D + L V R+
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 1748 LERRTK------EITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTV 1801
LER + T + G V P P VTW + Q + G T
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKI----KPGDNDKKYTF 31741
Query: 1802 DGTLVLHNLSIY-----DRGFYKCVASNPGGQDSLLVKIQVIAAPP----VILEQRRQVI 1852
+ L+ L+I D Y VA N G+DS K+ V PP + ++++
Sbjct: 31742 ESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801
Query: 1853 VGT---WGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG----TLYIR 1905
G+S+ G P P++ W DG +PL + + G L+IR
Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKWE-KDG---QPLSL-GPNIEIIHEGLDYYALHIR 31856
Query: 1906 NLASSDRGTYECIATSSTGS 1925
+ D G Y AT++ GS
Sbjct: 31857 DTLPEDTGYYRVTATNTAGS 31876
Score = 45.8 bits (107), Expect = 6e-04
Identities = 99/454 (21%), Positives = 160/454 (35%), Gaps = 51/454 (11%)
Query: 2146 SNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKL 2205
S K +I AG T + VTG P P W ++ + L I
Sbjct: 15109 SVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALR 15168
Query: 2206 LDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEG 2265
D G YV A N G +++V P + L T K + S D +E
Sbjct: 15169 KDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEI 15228
Query: 2266 TPSPEVMWIMPDNIFLT--APYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG--E 2321
T + D T P R G LE + + F +A+N+ G
Sbjct: 15229 TG---FIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYK------FRVIAKNKFGCGP 15279
Query: 2322 SVLVVQLEVLEMLRRPTF--RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRF 2379
V + + ++ L PT R + E+ + + S G+P +I+
Sbjct: 15280 PVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQG--YIIEKRRHD 15337
Query: 2380 SNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIE-----KLVILEIGQKPVI 2434
+ + SF++ ++R A N++G E +VI + P I
Sbjct: 15338 KPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTI 15397
Query: 2435 ---LTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRP----QINGKYILHD 2487
L+ T+K +GE + + G+P P I+W+ + V+++P QI + +
Sbjct: 15398 KLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWS-KNETVIEKPTDALQITKEEVSRS 15456
Query: 2488 NG--TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAA 2545
L I +A D+G Y A N +G V V + P PPR++ A
Sbjct: 15457 EAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRP-----SPPRNLAVTDIKA 15511
Query: 2546 FQLHCVALGVPKPEITWEMPDHSLLSTASKERTH 2579
+ +TW+ P L E TH
Sbjct: 15512 ESCY----------LTWDAP----LDNGGSEITH 15531
Score = 45.8 bits (107), Expect = 6e-04
Identities = 165/818 (20%), Positives = 285/818 (34%), Gaps = 99/818 (12%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916
G +++ P +G P P+ W +DG+E+K + + FS+ L I+N D G Y+
Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWT-TDGSEIKTDEHYTVETDNFSS-VLTIKNCLRRDTGEYQ 17582
Query: 1917 CIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWR 1976
+++ GS+ V LT+ ++ +N D + + + +P
Sbjct: 17583 ITVSNAAGSKTVAVHLTV--------LDVPGPPTGPINILDVTPEHMTISWQPPKDDGGS 17634
Query: 1977 LPSKAVVDQQH-RVGSWIHVYPNGS----LFIGSVTEKDSGVYLCVARNKMGDDLILMHV 2031
+V++Q R +W V +GS L I + + V+ A NK+G +
Sbjct: 17635 PVINYIVEKQDTRKDTW-GVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIG-----VGP 17688
Query: 2032 SLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLP--DG--TMINNAMQAD 2087
L P HK F GK D + + V SW+LP DG + M+
Sbjct: 17689 PLDSTPTVAKHK--FSPPSPPGKPVVTDITENAATV---SWTLPKSDGGSPITGYYMERR 17743
Query: 2088 DSGHRTRRYTLFNNGTLYFNKVGVAEEGDY--TCYAQNTLG-------KDEMKVHLTVIT 2138
+ + R L F G+ E Y +A+N G D +K +
Sbjct: 17744 EVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP 17803
Query: 2139 AAPRIRQSNKTNKR----------IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSID 2188
P I K R + G + +L V W + D + I
Sbjct: 17804 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDEL---IR 17860
Query: 2189 RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIK 2248
+ F G + N+ + + P + D++ PP + T R VI
Sbjct: 17861 QCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDIL-HPPEVELDVTCRDVIT 17919
Query: 2249 ATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDS 2308
+ + R +G P P++ W + L I L+I+ +D
Sbjct: 17920 VRVGQTIR--ILARVKGRPEPDITWTKEGKV-LVREKRVDLIQDLPRVELQIKEAVRADH 17976
Query: 2309 ADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPE 2368
+I A+N G + ++ +L RP P V + K NC++ P +
Sbjct: 17977 GKYIISAKNSSGHA---QGSAIVNVLDRP---GPCQNLKVTNVTKE---NCTISWENPLD 18027
Query: 2369 IIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEI 2428
G+ +N Y+ S + S T+ K A N+ Y ++
Sbjct: 18028 -----NGGSEITNFIVEYRKPNQKGWSIVASDVTKR-LIKANLLANNEY-YFRVCAENKV 18080
Query: 2429 GQKPVILTYAPGTVKGIS-----GESLSLHCVSDGIPKPNIKWTMP---------SGYVV 2474
G P I T P + I+ GE +LH G +KW P S +V
Sbjct: 18081 GVGPTIETKTP--ILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVE 18138
Query: 2475 DRPQINGKYILHDNGTL-----VIKEATAYDRGNYICKAQNSVGHT--LITVPVMIV--A 2525
R + + + G++ ++ + + +N G + + T V++
Sbjct: 18139 RRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDL 18198
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
P + + + + G +L G P PE+ W + T S +
Sbjct: 18199 QKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADS 18258
Query: 2586 LQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ +L + SD G Y TA N GS A + V+
Sbjct: 18259 SKFSLT--KAKRSDGGKYVVTATNTAGSFVAYATVNVL 18294
Score = 45.1 bits (105), Expect = 0.001
Identities = 49/178 (27%), Positives = 74/178 (41%), Gaps = 22/178 (12%)
Query: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG--KLELQMADSFDTGVYH 550
V L C G P V WL + ++R S L D+ L + D DTG Y
Sbjct: 4972 VELECEVTGTPPFEVTWL-KNNREIR----SSKKYTLTDRVSVFNLHITKCDPSDTGEYQ 5026
Query: 551 CISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW--- 607
CI SN + + R+ + EP ++ + + T + + G P SI+W
Sbjct: 5027 CIVSNEGGSCSCSTRVALKEP--PSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKD 5084
Query: 608 --VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD----FLIFQ 659
++ ++ +Y S D + TL+I V G Y C A N SGV+ FL+ Q
Sbjct: 5085 DQILDEDDNVYISFVD----SVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQ 5138
Score = 45.1 bits (105), Expect = 0.001
Identities = 73/385 (18%), Positives = 134/385 (34%), Gaps = 36/385 (9%)
Query: 1674 GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDH 1733
G P P I WT+ G L + K+ +Q LP L I+ D G+Y+ SA N G
Sbjct: 17934 GRPEPDITWTK--EGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQ 17991
Query: 1734 LHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQG 1793
++V+ P + +T T+ + + S +I+ + + +G
Sbjct: 17992 GSAIVNVLDRPGPCQNLKVTNVT-KENCTISWENPLDNGGSEITNFIVEYR---KPNQKG 18047
Query: 1794 SRQAVVTVDGTLVLHNLSIYDRGFYK-CVASNPGGQDSLLVKIQVIAAPPV--------- 1843
V L+ NL + +++ C + G ++ K ++A P+
Sbjct: 18048 WSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENL 18107
Query: 1844 -ILEQRRQVIVGTW------GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFL 1896
I ++ + + W G S L + + S W +K + +
Sbjct: 18108 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDR--C 18165
Query: 1897 FSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFG 1956
N R ++ G + + T + ++E + P ++ V G
Sbjct: 18166 VENQIYEFRVQTKNEGGESDWVKTEE---------VVVKEDLQKPVLDLKLSGVLTVKAG 18216
Query: 1957 DKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF-IGSVTEKDSGVYL 2015
D + L G+P P++ W K D I + S F + D G Y+
Sbjct: 18217 DTIRLEAGVRGKPFPEVAW-TKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 18275
Query: 2016 CVARNKMGDDLILMHVSLRLKPAKI 2040
A N G + V++ KP +
Sbjct: 18276 VTATNTAGSFVAYATVNVLDKPGPV 18300
Score = 45.1 bits (105), Expect = 0.001
Identities = 43/146 (29%), Positives = 64/146 (43%), Gaps = 20/146 (13%)
Query: 2396 FIISKTTREDAGKYRCAARNKVGYIEK-------LVILEIGQKPVI---LTYAPGTVKGI 2445
FIIS T+ ++R ARN VG I + ++ PVI L Y VK
Sbjct: 26827 FIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTE-VVKYR 26885
Query: 2446 SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGT----LVIKEATAYDR 2501
+G S+ L G P P I+W Y D+ + +N T ++IK+A +
Sbjct: 26886 AGTSVKLRAGISGKPAPTIEW-----YKDDKELQTNALVCVENTTDLASILIKDADRLNS 26940
Query: 2502 GNYICKAQNSVGHTLITVPVMIVAYP 2527
G Y K +N++G T+ V I+ P
Sbjct: 26941 GCYELKLRNAMGSASATIRVQILDKP 26966
Score = 45.1 bits (105), Expect = 0.001
Identities = 35/148 (23%), Positives = 64/148 (43%), Gaps = 10/148 (6%)
Query: 2392 SNGSFIISKTTREDAGKYRCAARNKVGYIEK------LVILEIGQKPVILTYAPGTVKGI 2445
S + ++ + D ++R ARN VG I +++ P I+ + P G+
Sbjct: 27909 SECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGL 27968
Query: 2446 ---SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRG 2502
SGESL + + G P P + W + R + +L +L +++AT RG
Sbjct: 27969 IIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST-SLFVRDATRDHRG 28027
Query: 2503 NYICKAQNSVGHTLITVPVMIVAYPPRI 2530
Y +A+N+ G + V + P ++
Sbjct: 28028 VYTVEAKNASGSAKAEIKVKVQDTPGKV 28055
Score = 45.1 bits (105), Expect = 0.001
Identities = 33/128 (25%), Positives = 53/128 (41%), Gaps = 22/128 (17%)
Query: 2495 EATAYDRGNYICKAQNSVG-----HTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLH 2549
EAT Y+ + A+N G T +++ + + + + + T+ G A QL
Sbjct: 30497 EATEYE---FRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLS 30553
Query: 2550 CVALGVPKPEITW-----EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYK 2604
C +G P P+I W E+ +S RTH TL + + D G+Y
Sbjct: 30554 CQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTH---------TLTVMTEEQEDEGVYT 30604
Query: 2605 CTAKNPLG 2612
C A N +G
Sbjct: 30605 CIATNEVG 30612
Score = 44.7 bits (104), Expect = 0.001
Identities = 62/304 (20%), Positives = 114/304 (37%), Gaps = 39/304 (12%)
Query: 1752 TKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLS 1811
T + V+ G + E + ++ W N + +S + V +D +
Sbjct: 27776 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLD-----YQFR 27830
Query: 1812 IYDRGFYKCVASNPGGQDSLLVKIQVIAAP--PVILEQRRQVIVGTWGESL-----KLPC 1864
+Y S+P + + + P P ++ R+ I W L K+
Sbjct: 27831 VYAEN--SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVG 27888
Query: 1865 TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG 1924
+ Q + WV + T+V Q+T + L+ DR + IA ++ G
Sbjct: 27889 YSIEKRQGNERWVRCNFTDVSECQYT-------------VTGLSPGDRYEFRIIARNAVG 27935
Query: 1925 -----SERRVVMLTMEERVTSPRIEAASQ--KRTEVNFGDKLLLNCSATGEPKPQIMWRL 1977
S+ +++T +E V P +E + + G+ L + G P P++ W
Sbjct: 27936 TISPPSQSSGIIMTRDENVP-PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTW-- 27992
Query: 1978 PSKAVVDQQHRVGSWI-HVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLK 2036
K V+ + R+ I V + SLF+ T GVY A+N G + V ++
Sbjct: 27993 -FKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDT 28051
Query: 2037 PAKI 2040
P K+
Sbjct: 28052 PGKV 28055
Score = 44.7 bits (104), Expect = 0.001
Identities = 53/216 (24%), Positives = 82/216 (37%), Gaps = 23/216 (10%)
Query: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNG-PQSYQYLIAS 2392
++ P F+ V +T L C V G+P P + W ++G Q
Sbjct: 30925 IQAPHFKEELRNLNVRYQSNAT-LVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGG 30983
Query: 2393 NGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKG------IS 2446
II+ T +DA Y+ A N+ G + LE+ I + P T++G +
Sbjct: 30984 YHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKI--HLPKTLEGMGAVHALR 31041
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKY---ILHDNGTLVIKEAT-AYDRG 2502
GE +S+ G P P I W + + NG Y + +LV D G
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQKGQDLIDN----NGHYQVIVTRSFTSLVFPNGVERKDAG 31097
Query: 2503 NYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSI 2538
Y+ A+N G TV + + P PPR +
Sbjct: 31098 FYVVCAKNRFGIDQKTVELDVADVPD-----PPRGV 31128
Score = 44.3 bits (103), Expect = 0.002
Identities = 47/189 (24%), Positives = 77/189 (40%), Gaps = 23/189 (12%)
Query: 480 NTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVR---APYVSEDGRILIDKSGKL 536
NT+++ LVGGT + + W D ++ A V +D D S L
Sbjct: 4782 NTRVQLKALVGGTAPMT----------IKWF-KDNKELHSGAARSVWKD-----DTSTSL 4825
Query: 537 ELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENGIHHTVFIGETLDLPC 595
EL A + D+G Y C SN D T + T+ V+ + ++ + G++ C
Sbjct: 4826 ELFAAKATDSGTYICQLSN--DVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFEC 4883
Query: 596 HSTGIPDASISWVIPGNNVLYQSSRDKKVLNN-GTLRILQVTPKDQGYYRCVAANPSGVD 654
TG P +SW + GN + ++ T +I ++ G Y C A N +G
Sbjct: 4884 QITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTA 4943
Query: 655 FLIFQVSVK 663
++ VK
Sbjct: 4944 SCSIELKVK 4952
Score = 44.3 bits (103), Expect = 0.002
Identities = 76/408 (18%), Positives = 148/408 (36%), Gaps = 58/408 (14%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT---LYIRNLASSDRG 1913
G++L++P G P P+ W +G + ++ + + GT L I++ D G
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEG------ELDKDRVVIDNVGTKSELIIKDALRKDHG 15172
Query: 1914 TYECIATSSTGSE---RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPK 1970
Y AT+S GS+ RV + + V + ++K +N+ D P+
Sbjct: 15173 RYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSD-----------PE 15221
Query: 1971 PQIMWRLPSKAVVDQQHRVGSWIHVYPN--GSLFIGSVTEKDSGVYLCVARNK------- 2021
+ + + ++ +W I + E + +A+NK
Sbjct: 15222 DDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPV 15281
Query: 2022 -MGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMI 2080
+G L + + P ++ + + + + D++ GSP+ G +I
Sbjct: 15282 EIGPILAVDPLGPPTSPERLTYTERTKSTIT--LDWKEPRSNGGSPI--------QGYII 15331
Query: 2081 NNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAA 2140
R + L N + + ++ A N +G+ E + L V+
Sbjct: 15332 EKRRHDKPDFERVNKRLCPTTSFLVEN-LDEHQMYEFRVKAVNEIGESEPSLPLNVVIQD 15390
Query: 2141 PRIRQSNKTNK-------RIKAGDTAVLDCEVTGDPKPKIFW------LLPSNDMISFSI 2187
+ + K ++KAG+ + +VTG P PKI W + D + +
Sbjct: 15391 DEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 15450
Query: 2188 DRYT-FHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKP 2234
+ + A L+I K D G Y A N G + ++V +P
Sbjct: 15451 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRP 15498
Score = 44.3 bits (103), Expect = 0.002
Identities = 25/86 (29%), Positives = 38/86 (44%), Gaps = 6/86 (6%)
Query: 2538 IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQT 2597
IV G ++ G P P +TW M + +L A+ E T + ++VI+N Q
Sbjct: 16534 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETT------AISSSMVIKNCQR 16587
Query: 2598 SDSGIYKCTAKNPLGSDYAATYIQVI 2623
S G+Y AKN G + V+
Sbjct: 16588 SHQGVYSLLAKNEAGERKKTIIVDVL 16613
Score = 44.3 bits (103), Expect = 0.002
Identities = 86/399 (21%), Positives = 141/399 (35%), Gaps = 79/399 (19%)
Query: 2264 EGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT-LEIRNVRLSDSADFICVARNEGGES 2322
+G P P+V W D T +RI V G+ LEIRN D + N G
Sbjct: 17243 KGVPFPKVTWKKEDRDAPTK----ARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSK 17298
Query: 2323 VLVVQLEVLEMLRRP---------------TFRNPFNEKIVAQLGKSTALNCSVDGNPPP 2367
+ V++ VL+ P T++ P ++ G S N V+
Sbjct: 17299 TVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDD------GGSVITNYVVERRDVA 17352
Query: 2368 EIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILE 2427
W + T + S + +R AA N +
Sbjct: 17353 SAQWSPLSAT-------------SKKKSHFAKHLNEGNQYLFRVAAEN-----------Q 17388
Query: 2428 IGQKPVILTYAPGTVKGIS-----GESLSLHCVSDGIPKPNIKWTMP--------SGYVV 2474
G+ P + T P +K + G LH V + ++ W P +GY+V
Sbjct: 17389 YGRGPFVET--PKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLV 17446
Query: 2475 DRPQINGK-YILHDNGTLVIKEATAYDRGN---YICKAQNSVGHTL--ITVPV----MIV 2524
+ + + +I T + T +G + KA+N VG L T+P+ +V
Sbjct: 17447 EYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLV 17506
Query: 2525 AYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQL 2584
+ + +V + G + + GVP P W D S + T + + E
Sbjct: 17507 PPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTT-DGSEIKT---DEHYTVETD 17562
Query: 2585 HLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ L I+N D+G Y+ T N GS A ++ V+
Sbjct: 17563 NFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 17601
Score = 44.3 bits (103), Expect = 0.002
Identities = 95/427 (22%), Positives = 155/427 (36%), Gaps = 47/427 (11%)
Query: 2217 NPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMP 2276
+PS K Y D++ P +T+I V +G P P++ W P
Sbjct: 19674 DPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVT---MRLYVPVKGRPPPKITWSKP 19730
Query: 2277 DNIFLTAPYYGSRITVHKNGT-----LEIRNVRLSDSADFICVARNEGGESVLVVQLEVL 2331
N+ L RI + T L NV D+ +I N G+ + ++VL
Sbjct: 19731 -NVNLR-----DRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVL 19784
Query: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNC----SVDGNPPPEIIWILPNGTRFSNGPQSYQ 2387
+ P V ++ K +A +DG P II + S
Sbjct: 19785 DTPGPPV------NVTVKEISKDSAYVTWEPPIIDGGSP--IINYVVQKRDAERKSWSTV 19836
Query: 2388 YLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQK--PVILTYAPGTVKGI 2445
S SF ++ + +R A N+ G I + G+ V + PG V +
Sbjct: 19837 TTECSKTSFRVANLEEGKSYFFRVFAENEYG------IGDPGETRDAVKASQTPGPVVDL 19890
Query: 2446 SGESLSLHCVSDGIPKPNIKW-TMPSGYVVDRPQINGKYILHDNGTLV---IKEATAYDR 2501
S+S S G KP+ + GYVVD K+ + K+ T
Sbjct: 19891 KVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKE 19950
Query: 2502 GNYICKAQNSVGH---TLITVPVM--IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVP 2556
+ A+N G + ITV +VA + P + + + F+L G P
Sbjct: 19951 YTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKP 20010
Query: 2557 KPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYA 2616
P ++W+ + L + + E + TL++ + Q SD+G Y T KN G+
Sbjct: 20011 APSVSWKKGEDPLAT----DTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEG 20066
Query: 2617 ATYIQVI 2623
I+V+
Sbjct: 20067 TISIKVV 20073
Score = 43.9 bits (102), Expect = 0.002
Identities = 84/407 (20%), Positives = 149/407 (36%), Gaps = 72/407 (17%)
Query: 1750 RRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHN 1809
RRT + V +G ++ + +GRP+P VTW N + + ++ + ++ L++
Sbjct: 20783 RRT--LVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTL----LIIPE 20836
Query: 1810 LSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGT 1869
+ YD G + NP G+ S V ++V+ P G L L T
Sbjct: 20837 CNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP---------------GPVLNLRPTDITK 20881
Query: 1870 PQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRV 1929
+++W L PL S++ T YI + R +Y T +V
Sbjct: 20882 DSVTLHWDL-------PLIDGGSRI------TNYIVEKREATRKSYSTATTKCHKCTYKV 20928
Query: 1930 ------------VMLTMEERVTSPRIEAASQKRTE-------VNFGDKLLLNCSATGEPK 1970
VM E + P K +E +N D + + + PK
Sbjct: 20929 TGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMD-ITKSTVSLAWPK 20987
Query: 1971 PQIMWRLPSKAVVDQQHRVGS--WIHVYPNGSL--FIGSVTEKDSGVYLCVARNKMGDDL 2026
P+ V + R GS W H+ L + ++TE + + +A N G
Sbjct: 20988 PKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSA 21047
Query: 2027 ILMHVSLRLKP----AKIDHKQYFRKQVL--HGKDFQVDCKASGSPVPEISWSLPDGTMI 2080
+ +K ++D + ++K V+ G + +V+ G P P ++W D
Sbjct: 21048 PRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGD---- 21103
Query: 2081 NNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
Q R T + L N+ ++ G Y A+N +G+
Sbjct: 21104 ----QILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGE 21146
Score = 43.9 bits (102), Expect = 0.002
Identities = 115/572 (20%), Positives = 213/572 (37%), Gaps = 90/572 (15%)
Query: 2105 YFNKVGVAEEGDYT--CYAQNTLGK-DEMKVHLTVITAA-----PRIRQSNKTNKRI--K 2154
+F G+ E+ Y A+N G E ITA PRI K I
Sbjct: 22497 HFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVH 22556
Query: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS-IDRYTFHANGSLTINKVKLLDSGEYVC 2213
AG++ +D ++ G P P I W+ ++ + + ++ + SL++ +DSG Y+
Sbjct: 22557 AGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYIL 22616
Query: 2214 VARNPSGDDTKMYKLDVVSK------PPLINGLYTNRTVI--KATAVRHSKKHFDCRAEG 2265
A+N +G+ + + V+ + P +I+G+ + + K + E
Sbjct: 22617 KAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVER 22676
Query: 2266 TPSPEVMWIMPD-NI---------FLTAPYYGSRI-TVHKNGTLE-IRNVRLSDSADFIC 2313
+ ++W + D N+ L Y RI V+K G E + + + F+
Sbjct: 22677 RETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVV 22736
Query: 2314 VARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
+ E V + ++ + RP A G S L ++ I W
Sbjct: 22737 PDAPKAPEVTTVTKDSMIVVWERP-----------ASDGGSEILGYVLEKRDKEGIRWTR 22785
Query: 2374 PNGTRFSN---------GPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLV 2424
+ Y++ +++ + +S+ + A + C K G
Sbjct: 22786 CHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPK 22845
Query: 2425 ILEIGQKPVILTYAPGTVKG---ISGESLSLHCVSDGIPKPNIKWTM---PSGYVVDRPQ 2478
+++I + V L+++ G I G + VS G +WTM P+G +++
Sbjct: 22846 VIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVG------EWTMCTPPTG--INKTN 22897
Query: 2479 INGKYILHDNGTLVIKEATAYDRGNYICKAQNSVG---HTLITVPVMI---VAYPPRITN 2532
I + +L + N+ A N G H + P+++ + P +
Sbjct: 22898 IEVEKLLEKH------------EYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 22945
Query: 2533 RPPRSIVT-RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLV 2591
R I+ R G + +L G P PE+ W D + A + T +LV
Sbjct: 22946 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFT------SLV 22999
Query: 2592 IQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ N DSG Y T +N G+ A ++V+
Sbjct: 23000 LDNVNRYDSGKYTLTLENSSGTKSAFVTVRVL 23031
Score = 43.9 bits (102), Expect = 0.002
Identities = 44/138 (31%), Positives = 58/138 (42%), Gaps = 16/138 (11%)
Query: 2493 IKEATAYDRGNYICKAQNSVG-HTLITVPVMIVAY----PPRITNRPP--RSIVTRTGAA 2545
+KE T Y N+ A NS G T+P +VA PP I + +V R A
Sbjct: 25068 LKENTEY---NFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASAT 25124
Query: 2546 FQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKC 2605
+L G P+PE+ WE + L A E T LVI N DSG Y
Sbjct: 25125 LRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTM------LVIDNVTRFDSGRYNL 25178
Query: 2606 TAKNPLGSDYAATYIQVI 2623
T +N GS A ++V+
Sbjct: 25179 TLENNSGSKTAFVNVRVL 25196
Score = 43.5 bits (101), Expect = 0.003
Identities = 43/169 (25%), Positives = 66/169 (39%), Gaps = 9/169 (5%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDK-SGKLELQMADSFDT 546
L V L C G P V W D ++R+ S+ +I + + D+ D
Sbjct: 5529 LKNAEVSLECELSGTPPFEVVWY-KDKRQLRS---SKKYKIASKNFHTSIHILNVDTSDI 5584
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G YHC + N +D + + EP + N + TV GE +L G +
Sbjct: 5585 GEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSL--TVVAGEPAELQASIEGAQPIFVQ 5642
Query: 607 WVIPGNNVLYQSS--RDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
W+ V+ +S R V N TL+ + P + G Y C N G+
Sbjct: 5643 WLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGM 5691
Score = 43.5 bits (101), Expect = 0.003
Identities = 44/172 (25%), Positives = 70/172 (40%), Gaps = 10/172 (5%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILI-DKSGKLELQMAD 542
+H+V G ++ L G V W DG + SE I+ +K+ LE+ +
Sbjct: 5994 DHSVEPGKSIILESTYTGTLPISVTWK-KDGFNITT---SEKCNIVTTEKTCILEILNST 6049
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
D G Y C N D+ ++ +EP + + V G+++ L C G P+
Sbjct: 6050 KRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAGTPE 6107
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNN--GTLRILQVTPKDQGYYRCVAANPSG 652
++SW G+ L + + N TL +V D G Y C A N G
Sbjct: 6108 ITVSW-YKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIG 6158
Score = 43.5 bits (101), Expect = 0.003
Identities = 47/178 (26%), Positives = 73/178 (41%), Gaps = 12/178 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G ++ L C G P V W D S++ + + I+ L + A + D+G Y
Sbjct: 6379 GESIQLECKISGSPEIKVSWFRND-SELHESW--KYNMSFINSVALLTINEASAEDSGDY 6435
Query: 550 HCISSN-YDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
C + N DA T +TV P V + + + G + L C +G P + WV
Sbjct: 6436 ICEAHNGVGDASCST-ALTVKAPPVFTQKPSPVG--ALKGSDVILQCEISGTPPFEVVWV 6492
Query: 609 IPGNNVLYQSSRDKKVLN---NGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
V ++S+ K+ + + +L IL + D G Y C A N G D V K
Sbjct: 6493 KDRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFK 6548
Score = 43.5 bits (101), Expect = 0.003
Identities = 42/175 (24%), Positives = 69/175 (39%), Gaps = 20/175 (11%)
Query: 497 CPGQGDPTPHVDWL-----LADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHC 551
C G P V W + + SK R +V D LE+ D+G Y C
Sbjct: 7327 CKIGGSPEIKVLWYKDETEIQESSKFRMSFV--------DSVAVLEMHNLSVEDSGDYTC 7378
Query: 552 ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPG 611
+ N + + + V EP + + + I G + L C G P +SW
Sbjct: 7379 EAHNAAGSASSSTSLKVKEPPIFRKKPHPIE--TLKGADVHLECELQGTPPFHVSWYKDK 7436
Query: 612 NNVLYQSSRDKKVLNNG---TLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
+ +S + K+++ ++ IL V D G Y+C A N G D + +++K
Sbjct: 7437 REL--RSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALK 7489
Score = 43.5 bits (101), Expect = 0.003
Identities = 43/173 (24%), Positives = 66/173 (38%), Gaps = 11/173 (6%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILI---DKSGKLELQMADS 543
V G T L C G P W DG ++ + D + I +K L++
Sbjct: 7597 VTTGDTCTLECTVAGTPELSTKWF-KDGKEL-----TSDNKYKISFFNKVSGLKIINVAP 7650
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI-GETLDLPCHSTGIPD 602
D+GVY N D T + V + V + T + G ++ + C G P
Sbjct: 7651 SDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPP 7710
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPSGVD 654
S+SW GN + + +N L + + D G Y C+A N +G D
Sbjct: 7711 ISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSD 7763
Score = 43.5 bits (101), Expect = 0.003
Identities = 103/485 (21%), Positives = 188/485 (38%), Gaps = 68/485 (14%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLL------PSNDMISFSIDRYTFHANGSLTINKVKLL 2206
+ AG+TA DCE++ + P + W L PS+ ++ S + +LT+ VKL
Sbjct: 12207 VTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGKV-----HTLTLRDVKLE 12260
Query: 2207 DSGEYVCVARNPSGDDTKMYKLDVVSKPPL-INGLYTNRTVIK-ATAVRHSKKHFDCRAE 2264
D+GE A+ D K + V +PP+ ++TV + ATAV +C
Sbjct: 12261 DAGEVQLTAK-----DFKTHANLFVKEPPVEFTKPLEDQTVEEGATAV------LECEV- 12308
Query: 2265 GTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVL 2324
+ +V W L + Y + + L I + D + C A++ L
Sbjct: 12309 SRENAKVKWFKNGTEILKSKKY-EIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNL 12367
Query: 2325 VVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQ 2384
V +E L RP EK +A+ C + ++ W +G G
Sbjct: 12368 NVVPPHVEFL-RPLTDLQVREKEMAR------FECEL-SRENAKVKW-FKDGAEIKKGK- 12417
Query: 2385 SYQYLIASNGS---FIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGT 2441
+Y I S G+ +I+K +D +Y C R +L + ++ + T
Sbjct: 12418 --KYDIISKGAVRILVINKCLLDDEAEYSCEVRT----ARTSGMLTVLEEEAVFTKNLAN 12471
Query: 2442 VKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG---TLVIKEATA 2498
++ +++ L C P + W +++ G+Y + G LVI+ A
Sbjct: 12472 IEVSETDTIKLVC-EVSKPGAEVIWYKGDEEIIE----TGRYEILTEGRKRILVIQNAHL 12526
Query: 2499 YDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKP 2558
D GNY C+ +S + V + + + P+++ G + C ++
Sbjct: 12527 EDAGNYNCRLPSSRTDGKVKVHELAAEFISK-----PQNLEILEGEKAEFVC-SISKESF 12580
Query: 2559 EITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAAT 2618
+ W+ D +L S + + + LV+++ D G Y +G+ AA
Sbjct: 12581 PVQWKRDDKTLESGDKYDVIADGK----KRVLVVKDATLQDMGTYVVM----VGAARAAA 12632
Query: 2619 YIQVI 2623
++ VI
Sbjct: 12633 HLTVI 12637
Score = 43.5 bits (101), Expect = 0.003
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 5/85 (5%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFH---ANGSLTINKVKLLDSG 2209
+KAG L VTG P+PKI W DMI R T ++TI K D+G
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITW--TKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 13759
Query: 2210 EYVCVARNPSGDDTKMYKLDVVSKP 2234
Y+ A N G T + +++V+ KP
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 43.5 bits (101), Expect = 0.003
Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 11/124 (8%)
Query: 1744 PPRIL--ERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTV 1801
PP ++ +E + G T+ L +G P P VTW ++ +++ R V V
Sbjct: 17215 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKA----RIDVTPV 17270
Query: 1802 DGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP-----VILEQRRQVIVGTW 1856
L + N + D G Y NP G ++ VK+ V+ P + E R+ TW
Sbjct: 17271 GSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTW 17330
Query: 1857 GESL 1860
E L
Sbjct: 17331 KEPL 17334
Score = 43.5 bits (101), Expect = 0.003
Identities = 83/384 (21%), Positives = 133/384 (34%), Gaps = 67/384 (17%)
Query: 1674 GNPLPTIHWTRVPSGLDLSKRK------QNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727
G P P + W +V G+D RK V+PN T D G+Y + N
Sbjct: 18632 GRPAPKVTWRKV--GIDNVVRKGQVDLVDTMAFLVIPNSTRD-------DSGKYSLTLVN 18682
Query: 1728 LFGTDHLHVTLSVVSYPPRILERRTKEITVHS-----------GSTVELKCRAEGRPSPT 1776
G + V + V+ P + + + ++T S G + E R +
Sbjct: 18683 PAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADR 18742
Query: 1777 VTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLL-VKI 1835
TW TV E + S V G + +++ A N G V
Sbjct: 18743 KTW----STVTPEVKKTSFHVTNLVPG----------NEYYFRVTAVNEYGPGVPTDVPK 18788
Query: 1836 QVIAAPPV----------ILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVK 1885
V+A+ P+ + E + W LP G + Y + S E +
Sbjct: 18789 PVLASDPLSEPDPPRKLEVTEMTKNSATLAW-----LPPLRDGGAKIDGY-ITSYREEEQ 18842
Query: 1886 PLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG---SERRVVMLTMEERVTSPR 1942
P ++ + + +L + L + + A ++ G + +E++ P+
Sbjct: 18843 PADRW-TEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPK 18901
Query: 1943 IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS-L 2001
I Q + G KL + G+P P W+ VV H +H + S L
Sbjct: 18902 ILMPEQ--ITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLA---VHKADSSSIL 18956
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDD 2025
I VT KDSG Y A N G D
Sbjct: 18957 IIKDVTRKDSGYYSLTAENSSGTD 18980
Score = 43.5 bits (101), Expect = 0.003
Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 8/102 (7%)
Query: 1744 PPRI-LERRTKE-ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTV 1801
PPRI ++ + K+ I VH+G + ++ G+P PT+ WI +Q E S +R + +
Sbjct: 22540 PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ----ELSNTARLEIKST 22595
Query: 1802 D--GTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
D +L + + D G Y A N G+ S+ V ++V+ P
Sbjct: 22596 DFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/106 (27%), Positives = 49/106 (46%), Gaps = 11/106 (10%)
Query: 1740 VVSYPPRILERRTKE-ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAV 1798
++ YP L+ R +E I V G + L +G+P P W Q + S++A+
Sbjct: 30130 MLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI-------SKRAM 30182
Query: 1799 VTVDGT---LVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
+ T LV+ D G Y V N G+ ++ +K++VI +P
Sbjct: 30183 IATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSP 30228
Score = 43.1 bits (100), Expect = 0.004
Identities = 62/235 (26%), Positives = 90/235 (38%), Gaps = 33/235 (14%)
Query: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNA----MQADDSGHRTRRYTLFNNGTLY 2105
VL G + SG PVPE+SW DG +I+ + +Q S R + L
Sbjct: 17 VLEGSTATFEAHISGFPVPEVSW-FRDGQVISTSTLPGVQISFSDGRAK---------LT 66
Query: 2106 FNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV--ITAAPRIRQSNKTNKRIKAGDTAVLDC 2163
V A G Y+ A N G+ L V TA P Q + ++ G L
Sbjct: 67 IPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQ-RLQSMTVRQGSQVRLQV 125
Query: 2164 EVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG---SLTINKVKLLDSGEYVCVARNPSG 2220
VTG P P + + + I S+D + G SL I + DSG Y A N G
Sbjct: 126 RVTGIPTPVVKFYRDGAE-IQSSLD-FQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKK---------HFDCRAEGT 2266
T +L V + + +T++ + S++ HFD R+ T
Sbjct: 184 RATSTAELLVQGEEEV--PAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIAT 236
Score = 43.1 bits (100), Expect = 0.004
Identities = 44/176 (25%), Positives = 75/176 (42%), Gaps = 20/176 (11%)
Query: 485 HTVLVGGTVGLNCPGQGDPTPHVDWL-----LADGSKVRAPYVSEDGRILIDKSGKLELQ 539
+ +L G + L+C +G P V W L++ + VR +V+ + IL K+E
Sbjct: 3747 YLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEA-ILDITDVKVE-- 3803
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
D+G Y C + N +D + I + EP ++ + + G L C +G
Sbjct: 3804 -----DSGSYSCEAVNDVGSDSCSTEIVIKEP--PSFIKTLEPADIVRGTNALLQCEVSG 3856
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQV---TPKDQGYYRCVAANPSG 652
ISW + +SS+ ++ + +L L++ D G Y CV AN G
Sbjct: 3857 TGPFEISWFKDKKQI--RSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Score = 42.7 bits (99), Expect = 0.005
Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 5/106 (4%)
Query: 2517 ITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKE 2576
+ PV I PP + + +++ G + L C G P P +TW D+ + S+ +
Sbjct: 932 VPAPVEIPVTPPTLVSGL-KNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ 990
Query: 2577 RTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
T S L+I+ DSG + C+A N G+ + Y+ V
Sbjct: 991 ITFQSG----IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Score = 42.7 bits (99), Expect = 0.005
Identities = 44/174 (25%), Positives = 67/174 (38%), Gaps = 11/174 (6%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV VG T L C G P V+W DG + + + +K L + + D
Sbjct: 5714 TVTVGETCTLECKVAGTPELSVEWY-KDGKLLTSSQKHKFS--FYNKISSLRILSVERQD 5770
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTV-FIGETLDLPCHSTGIPDAS 604
G Y N T + V + V + +T +G + L C G S
Sbjct: 5771 AGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPIS 5830
Query: 605 ISWVIPGNNVL----YQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
++W ++ YQ++ V TL++ + D G Y CVAAN +G D
Sbjct: 5831 VAWFHEKTKIVSGAKYQTTFSDNVC---TLQLNSLDSSDMGNYTCVAANVAGSD 5881
Score = 42.7 bits (99), Expect = 0.005
Identities = 84/388 (21%), Positives = 142/388 (36%), Gaps = 57/388 (14%)
Query: 2265 GTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVL 2324
G P P V W M + T P + T + ++ I+N + S + +A+NE GE
Sbjct: 16550 GKPPPTVTWNMNER---TLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKK 16606
Query: 2325 VVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPP-PEIIWILPNGTRFSNGP 2383
+ ++VL++ P + + K T + DG P + R + P
Sbjct: 16607 TIIVDVLDV-PGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTP 16665
Query: 2384 QSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGY---------------------IEK 2422
+Y + + + + A +R AA N +G E
Sbjct: 16666 VTYT---VTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPED 16722
Query: 2423 LVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGK 2482
L + E+ + V LT+ P G S + + + + + T V + ++ K
Sbjct: 16723 LEVKEVTKNTVTLTWNPPKYDGGSE-------IINYVLESRLIGTEKFHKVTNDNLLSRK 16775
Query: 2483 YILHDNGTLVIKEATAYDRGNYICKAQNSVGH---TLITVPVMIV--AYPPRITNRPPRS 2537
Y + +KE Y+ Y A N VG + T P+ PP +
Sbjct: 16776 YTVKG-----LKEGDTYE---YRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDK 16827
Query: 2538 IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQ--NP 2595
+ R G AF L G PKP+++W + +L +RTH TL ++
Sbjct: 16828 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVL---EDDRTHIKT---TPATLALEKIKA 16881
Query: 2596 QTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ SDSG Y +N GS + V+
Sbjct: 16882 KRSDSGKYCVVVENSTGSRKGFCQVNVV 16909
Score = 42.7 bits (99), Expect = 0.005
Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 2541 RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDS 2600
+ G +L + GVP P++TW+ D + A + T +L I+N D
Sbjct: 17231 KVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLE------IRNAAHEDG 17284
Query: 2601 GIYKCTAKNPLGSDYAATYIQVI 2623
GIY T +NP GS + + V+
Sbjct: 17285 GIYSLTVENPAGSKTVSVKVLVL 17307
Score = 42.7 bits (99), Expect = 0.005
Identities = 62/243 (25%), Positives = 93/243 (38%), Gaps = 40/243 (16%)
Query: 2408 KYRCAARNKVGYIEKLVILEIGQKPVILT---YAPGTVKGISGESLSLHCVSDGIPKPNI 2464
++R A N++G E + +PV+ PG + H ++ G KP
Sbjct: 18467 QFRVKAENEIGIGEP----SLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVY 18522
Query: 2465 KWTMPS-GYVVD-RPQI------NGKYILHDNGTLVIKE--ATAYDRGNY----ICKAQN 2510
P GYVV+ RP+I G + LV KE T+ D +C AQN
Sbjct: 18523 DGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVC-AQN 18581
Query: 2511 SVGHTLITVPVMIV-AYPPRITNRPP---------RSIVTRTGAAFQLHCVALGVPKPEI 2560
VG I P + A P+ PP + ++ R G +L + G P P++
Sbjct: 18582 QVG---IGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKV 18638
Query: 2561 TWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYI 2620
TW + + R + + LVI N DSG Y T NP G +
Sbjct: 18639 TWRK-----VGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNV 18693
Query: 2621 QVI 2623
+V+
Sbjct: 18694 RVL 18696
Score = 42.7 bits (99), Expect = 0.005
Identities = 30/96 (31%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSI 1812
K I + +G ++ L +GRP+P V W V E + V + +LVL N++
Sbjct: 22950 KIINIRAGGSLRLFVPIKGRPTPEVKW----GKVDGEIRDAAIIDVTSSFTSLVLDNVNR 23005
Query: 1813 YDRGFYKCVASNPGGQDSLLVKIQVI--AAPPVILE 1846
YD G Y N G S V ++V+ +PPV L+
Sbjct: 23006 YDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLK 23041
Score = 42.4 bits (98), Expect = 0.006
Identities = 46/187 (24%), Positives = 77/187 (41%), Gaps = 12/187 (6%)
Query: 482 KLEHTVLV--GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
KLE + +V G + L C G P V W ++ P + ID +++
Sbjct: 5428 KLEASKIVKAGDSSRLECKIAGSPEIRVVWFR---NEHELPASDKYRMTFIDSVAVIQMN 5484
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
+ D+G + C + N + + ++ V EP V + I T+ E + L C +G
Sbjct: 5485 NLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFS-SFPPIVETLKNAE-VSLECELSG 5542
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNG---TLRILQVTPKDQGYYRCVAANPSGVDFL 656
P + W + +SS+ K+ + ++ IL V D G Y C A N G D
Sbjct: 5543 TPPFEVVWYKDKRQL--RSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTC 5600
Query: 657 IFQVSVK 663
+ V +K
Sbjct: 5601 VCTVKLK 5607
Score = 42.4 bits (98), Expect = 0.006
Identities = 96/468 (20%), Positives = 166/468 (35%), Gaps = 65/468 (13%)
Query: 2092 RTRRYTLFN--NGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQ--SN 2147
RT Y + N G Y+ +V C Q + V I AP I +
Sbjct: 27223 RTTEYVVSNLKPGVNYYFRVSAVN-----CAGQGEPIEMNEPVQAKDILEAPEIDLDVAL 27277
Query: 2148 KTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS---LTINKVK 2204
+T+ KAG+ + G P P + W ++ S + RY+ S LTI +V
Sbjct: 27278 RTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA--RYSIENTDSSSLLTIPQVT 27335
Query: 2205 LLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAE 2264
D+G+Y+ N G+ K VS L + +K + +D
Sbjct: 27336 RNDTGKYILTIENGVGEP----KSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLI 27391
Query: 2265 GTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFI--CVARNEGGES 2322
SP + +++ + + HK + + + LS+ F +A NE G
Sbjct: 27392 DGGSPIINYVIEKRDATKRTW---SVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIG-- 27446
Query: 2323 VLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNG 2382
+ E E ++ P + + K++ + + W P+ F G
Sbjct: 27447 -IGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVI-----------LSWTKPD---FDGG 27491
Query: 2383 PQSYQYLIASNGS---------------FIISKTTREDAGKYRCAARNKVGYIEKLVILE 2427
+Y++ G +S+ + ++R A+N+ G + + I
Sbjct: 27492 SVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGP 27551
Query: 2428 IGQKPVILTYA------PGTVKGIS-GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQIN 2480
I K +I+T PG + G ++ L G PKP+I W + G + +
Sbjct: 27552 ITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISW-LKDGLPLKESEFV 27610
Query: 2481 GKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPP 2528
+ TL IK A G Y N+V I VP+ ++ P
Sbjct: 27611 RFSKTENKITLSIKNAKKEHGGKYTVILDNAV--CRIAVPITVITLGP 27656
Score = 42.4 bits (98), Expect = 0.006
Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 16/141 (11%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPP-------RILERRTKEITVHSG 1760
L+I V D +Y A N +G D L+V +PP + +R G
Sbjct: 31750 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEG 31809
Query: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG----TLVLHNLSIYDRG 1816
+V + R G P PT+ W Q + S G ++ +G L + + D G
Sbjct: 31810 QSVCFEIRVSGIPPPTLKWEKDGQPL----SLGPNIEIIH-EGLDYYALHIRDTLPEDTG 31864
Query: 1817 FYKCVASNPGGQDSLLVKIQV 1837
+Y+ A+N G S +QV
Sbjct: 31865 YYRVTATNTAGSTSCQAHLQV 31885
Score = 42.0 bits (97), Expect = 0.008
Identities = 55/234 (23%), Positives = 91/234 (38%), Gaps = 30/234 (12%)
Query: 2409 YRCAARNKVG-----YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPN 2463
++ ARNK G Y+++ V + P + P VK + S+ D P N
Sbjct: 13559 FKVCARNKCGPGEPAYVDEPVNMST---PATVPDPPENVKWRDRTANSIFLTWD--PPKN 13613
Query: 2464 IKWTMPSGYVVDR-PQINGKYILHDNGTLVIK-EATAYDRGN---YICKAQNSVGHTLIT 2518
+ GY+V+R P+ + K++ K E T + G Y KA N G + +
Sbjct: 13614 DGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPS 13673
Query: 2519 VPVMIVAYPPRITNRPPR---------SIVTRTGAAFQLHCVALGVPKPEITWEMPDHSL 2569
P + T P + + G +L G P+P+ITW D L
Sbjct: 13674 RPTEEIQAVD--TQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMIL 13731
Query: 2570 LSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+++ E + + T+ I + + SD+G Y A N G A + V+
Sbjct: 13732 ----KQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVL 13781
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 3/91 (3%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWL--LPSNDMISFSIDRYTFHANGS-LTINKVKLLDSG 2209
+KAGDT L+ V G P P++ W + D+ + A+ S ++ K K D G
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 18272
Query: 2210 EYVCVARNPSGDDTKMYKLDVVSKPPLINGL 2240
+YV A N +G ++V+ KP + L
Sbjct: 18273 KYVVTATNTAGSFVAYATVNVLDKPGPVRNL 18303
Score = 42.0 bits (97), Expect = 0.008
Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 6/88 (6%)
Query: 2536 RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNP 2595
++++ + GA+F + G P P + W PD L + A + T + +L I+N
Sbjct: 26194 KTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDS------RTSLTIENA 26247
Query: 2596 QTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+DSG Y T +N L + ++V+
Sbjct: 26248 NRNDSGKYTLTIQNVLSAASLTLVVKVL 26275
Score = 41.6 bits (96), Expect = 0.010
Identities = 41/193 (21%), Positives = 71/193 (36%), Gaps = 20/193 (10%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWL-----LADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+VG + C G V W + G K + Y ++ S L + D
Sbjct: 8165 VVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISY--------LENSAHLTVLKVD 8216
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTV--FIGETLDLPCHSTGI 600
D+G Y C + N D T ++ + E L+ + TV G + L G
Sbjct: 8217 KGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGS 8276
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP---KDQGYYRCVAANPSGVDFLI 657
+++W NN+ Q + + ++ +LQV D G Y C +N +G
Sbjct: 8277 QPITVAWY--KNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCT 8334
Query: 658 FQVSVKMKGQRPL 670
+ +K + P+
Sbjct: 8335 SSIVIKEPKKPPV 8347
Score = 41.6 bits (96), Expect = 0.010
Identities = 126/641 (19%), Positives = 229/641 (35%), Gaps = 82/641 (12%)
Query: 1902 LYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLL 1961
L+I ++ SD G Y C+ + L +EE R ++ V G L L
Sbjct: 11175 LHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEE--LPVRFVKTLEEEVTVVKGQPLYL 11232
Query: 1962 NCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNK 2021
+C E ++WR K VV++ R+ + + +L I + D+G Y N
Sbjct: 11233 SCELNKE--RDVVWRKDGKIVVEKPGRIVPGV-IGLMRALTINDADDTDAGTYTVTVENA 11289
Query: 2022 MGDDLILMHVSLRLKPAKIDHK---QYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGT 2078
+ S +K ++ + R Q + K + P I W
Sbjct: 11290 NN-----LECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKG--- 11341
Query: 2079 MINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV-- 2136
+ + A+ + + + +G + K+ A D YA GK LT+
Sbjct: 11342 --YDEIPAEPND----KTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGK-RYPAKLTLGE 11394
Query: 2137 --ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA 2194
+ I K + D + + ++ G K K L PS A
Sbjct: 11395 REVELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRPS--------PTCEIKA 11446
Query: 2195 NGS---LTINKVKLLDSGEYVCVARNPSGDDTKMYK-LDVVSKPPLINGLYTNRTVIKAT 2250
G LT++KVKL +GE + A N K +++ PL + T
Sbjct: 11447 EGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKD----------VT 11496
Query: 2251 AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSAD 2310
+ F+C T V+W +I ++ + I K L I + + D
Sbjct: 11497 VPERRQARFECVL--TREANVIWSKGPDIIKSSDKF-DIIADGKKHILVINDSQFDDEG- 11552
Query: 2311 FICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEII 2370
+ A EG ++ + + + R F +P ++ V + G++ C + + ++
Sbjct: 11553 -VYTAEVEGKKTSARLFVTGI----RLKFMSPLEDQTVKE-GETATFVCEL-SHEKMHVV 11605
Query: 2371 WILPNGTRFSNGPQSYQYLIASNG---SFIISKTTREDAGKYRCAARNKVGYIEKLVILE 2427
W + + S LI+S G + + T +D + + +V + L+
Sbjct: 11606 WFKNDAKLHT----SRTVLISSEGKTHKLEMKEVTLDDISQIKA----QVKELSSTAQLK 11657
Query: 2428 IGQKPVILTYAPGTVKGISGESLSLHC-VSDGIPKPNIKWTMPSGYVVDRPQINGKYILH 2486
+ + T + + ++L C VS +P +KW +V P KY +
Sbjct: 11658 VLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVP---VKWFKDGEEIVPSP----KYSIK 11710
Query: 2487 DNG---TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIV 2524
+G L IK+A D+G Y+C +TV ++
Sbjct: 11711 ADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLI 11751
Score = 41.6 bits (96), Expect = 0.010
Identities = 41/152 (26%), Positives = 68/152 (44%), Gaps = 23/152 (15%)
Query: 2400 KTTREDAG-KYRCAARNKVGY-----IEKLVILEIGQKPVIL--TYAPGTVKGISGESLS 2451
K RE A K R +A N G + + + E + P + G ++ ++G++L
Sbjct: 15064 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 15123
Query: 2452 LHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGT---LVIKEATAYDRGNYICKA 2508
+ V G P P WT G + D+ ++ ++ + GT L+IK+A D G Y+ A
Sbjct: 15124 IPAVVTGRPVPTKVWTKEEGEL-DKDRV----VIDNVGTKSELIIKDALRKDHGRYVITA 15178
Query: 2509 QNSVGH-------TLITVPVMIVAYPPRITNR 2533
NS G + VP ++ P +TNR
Sbjct: 15179 TNSCGSKFAAARVEVFDVPGPVLDLKPVVTNR 15210
Score = 41.6 bits (96), Expect = 0.010
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 11/165 (6%)
Query: 2463 NIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTL----IT 2518
++KW + +G + + + + TL IK+A+ D G C ++ G +T
Sbjct: 33067 DVKWVL-NGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLT 33125
Query: 2519 VPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERT 2578
+ + P I+ PRS G C G P PEI W ++ +S +S
Sbjct: 33126 LSKELSDAPAFISQ--PRSQNINEGQNVLFTCEISGEPSPEIEW-FKNNLPISISSNVSI 33182
Query: 2579 HGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
S ++ +L I+N SDSG Y AKN G A + V+
Sbjct: 33183 SRSRNVY---SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 33224
Score = 41.2 bits (95), Expect = 0.014
Identities = 41/168 (24%), Positives = 69/168 (41%), Gaps = 7/168 (4%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
L G V L C G P V W+ D +VR + D S L + ++ D G
Sbjct: 6470 LKGSDVILQCEISGTPPFEVVWV-KDRKQVRNSKKFKITSKHFDTS--LHILNLEASDVG 6526
Query: 548 VYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
YHC ++N +D + + EP + + + IG+ ++L G S+ W
Sbjct: 6527 EYHCKATNEVGSDTCSCSVKFKEP--PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVW 6584
Query: 608 VIPGNNVLYQS--SRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
+ V+ +S +R + N TL++ + G Y C N +G+
Sbjct: 6585 LKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGM 6632
Score = 41.2 bits (95), Expect = 0.014
Identities = 97/458 (21%), Positives = 159/458 (34%), Gaps = 84/458 (18%)
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGD 2168
V A E D + L KD ++ ++ A + + IK GDT L + G
Sbjct: 17192 VNAAGESDPAHVPEPVLVKDRLEPPELILDA------NMAREQHIKVGDTLRLSAIIKGV 17245
Query: 2169 PKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKL 2228
P PK+ W D + + T L I D G Y NP+G T K+
Sbjct: 17246 PFPKVTWKKEDRDAPTKARIDVT-PVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKV 17304
Query: 2229 DVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSP-EVMWIMPDNIFLT----A 2283
V+ KP G P EV I D+ +LT
Sbjct: 17305 LVLDKP------------------------------GPPRDLEVSEIRKDSCYLTWKEPL 17334
Query: 2284 PYYGSRITVHKNGTLEIRNVRLSDSADFICVAR---------NEGGESVLVVQLEVLEML 2334
GS IT N +E R+V + + ++ NEG + + V E +
Sbjct: 17335 DDGGSVIT---NYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAE-NQYG 17390
Query: 2335 RRPTFRNPFNEKIVAQL---GKSTALNCSVDGNPPPEIIWILPN---GTRFSNGPQSYQ- 2387
R P P K + L G L+ ++W P+ G+ + YQ
Sbjct: 17391 RGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE 17450
Query: 2388 --------YLIASNGSFIISKTTREDAGKYRCAARNKV--GYIEKLVILEIGQK--PVIL 2435
+ +N +++ + ++R A N V G + + +E +K P +
Sbjct: 17451 EGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSV 17510
Query: 2436 TYAPGTVKGI---SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILH-DN--G 2489
++G+ +G ++ + G+P P KWT + + + Y + DN
Sbjct: 17511 ELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI----KTDEHYTVETDNFSS 17566
Query: 2490 TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYP 2527
L IK D G Y N+ G + V + ++ P
Sbjct: 17567 VLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 17604
Score = 41.2 bits (95), Expect = 0.014
Identities = 40/167 (23%), Positives = 70/167 (41%), Gaps = 19/167 (11%)
Query: 2470 SGYVVDRPQINGKYILHDN-GT------LVIKEATAYDRGNYICKAQNS--VGHTLITVP 2520
+GYVV+ ++ + + D GT V+ + ++ N+ A N VG +
Sbjct: 20705 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPD 20764
Query: 2521 VMIV----AYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKE 2576
V IV A + R++V R G + ++ G P PE+TW + +L + A+ E
Sbjct: 20765 VEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIE 20824
Query: 2577 RTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
T L+I D+G + T +NP G ++V+
Sbjct: 20825 NTESFT------LLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVL 20865
Score = 41.2 bits (95), Expect = 0.014
Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 23/227 (10%)
Query: 2409 YRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW-T 2467
+R A N+ G E E PV + AP ++ ++ VS PKP +
Sbjct: 20939 FRVMAENEYGIGEPTETTE----PVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGS 20994
Query: 2468 MPSGYVVDRPQINGKYILHDNGT----LVIKEATAYDRGNYICKAQNSVGHTLI--TVPV 2521
+GYV++ + H V++ T + + A NS G + + PV
Sbjct: 20995 KITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPV 21054
Query: 2522 MIVAYP--PRITNRP--PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLST--ASK 2575
++ P + R + ++ + G ++ LG PKP +TW+ D L T +
Sbjct: 21055 IVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNF 21114
Query: 2576 ERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
E T S L++ + SDSG Y TA+N +G IQV
Sbjct: 21115 ETTATSTILNINECV------RSDSGPYPLTARNIVGEVGDVITIQV 21155
Score = 41.2 bits (95), Expect = 0.014
Identities = 92/449 (20%), Positives = 159/449 (35%), Gaps = 70/449 (15%)
Query: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI--KAGDTAVLDCE 2164
NKVG+ G+ T +D+++ AP + ++ K I +AG +A +
Sbjct: 23999 NKVGL---GEATSVPGTVKPEDKLE--------APELDLDSELRKGIVVRAGGSARIHIP 24047
Query: 2165 VTGDPKPKIFWLLPSNDMIS-FSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDT 2223
G P P+I W + I++ + L+I+ D+G+Y+ N SG +
Sbjct: 24048 FKGRPTPEITWSREEGEFTDKVQIEKGVNYTQ--LSIDNCDRNDAGKYILKLENSSGSKS 24105
Query: 2224 KMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTP----SPEVMWIMPDNI 2279
+ V+ P L AV+ +K P +V + D
Sbjct: 24106 AFVTVKVLDTPGPPQNL----------AVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKR 24155
Query: 2280 FLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF 2339
T Y + + + ++ N+ F +A NE G V V ++ ++ P+
Sbjct: 24156 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 24215
Query: 2340 RNPFNEKIVAQL------------GKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQ 2387
V+Q G S L V+ P W + ++ N
Sbjct: 24216 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNA----- 24270
Query: 2388 YLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVI---LTYAPG---- 2440
+++ + ++R A N+ G + V+ PVI LT P
Sbjct: 24271 ---------VVTGLSSGQEYQFRVKAYNEKGKSDPRVL----GVPVIAKDLTIQPSLKLP 24317
Query: 2441 --TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATA 2498
T +GE L + G P+PNI W + ++N + + L IKE
Sbjct: 24318 FNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETA-TSTVLHIKEGNK 24376
Query: 2499 YDRGNYICKAQNSVGHTLITVPVMIVAYP 2527
D G Y A NS G + V+++ P
Sbjct: 24377 DDFGKYTVTATNSAGTATENLSVIVLEKP 24405
Score = 41.2 bits (95), Expect = 0.014
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 3/90 (3%)
Query: 2449 SLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKA 2508
+L L G P+P +KW G + DR QI + LVI T +D G Y
Sbjct: 25124 TLRLFVTIKGRPEPEVKWEKAEGILTDRAQIE---VTSSFTMLVIDNVTRFDSGRYNLTL 25180
Query: 2509 QNSVGHTLITVPVMIVAYPPRITNRPPRSI 2538
+N+ G V V ++ P N R +
Sbjct: 25181 ENNSGSKTAFVNVRVLDSPSAPVNLTIREV 25210
Score = 40.8 bits (94), Expect = 0.018
Identities = 41/173 (23%), Positives = 72/173 (41%), Gaps = 21/173 (12%)
Query: 500 QGDPTPHVDWLLADGSKVRAP--YVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYD 557
+G P + W D V P ++ +G + L L D+ TG Y C +N
Sbjct: 5354 KGTPPFKIKWFKDDVELVSGPKCFIGLEG-----STSFLNLYSVDASKTGQYTCHVTNDV 5408
Query: 558 DADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV-----IP 610
+D T + V EP V+ + + I V G++ L C G P+ + W +P
Sbjct: 5409 GSDSCTTMLLVTEPPKFVKKLEASKI---VKAGDSSRLECKIAGSPEIRVVWFRNEHELP 5465
Query: 611 GNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
++ + D + +++ ++ +D G + C A NP+G +V VK
Sbjct: 5466 ASDKYRMTFIDSVAV----IQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVK 5514
Score = 40.8 bits (94), Expect = 0.018
Identities = 42/178 (23%), Positives = 72/178 (40%), Gaps = 9/178 (5%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDK-SGKLELQMADSFDT 546
L G V L C QG P HV W D ++R+ + +I+ + + + D+ D
Sbjct: 7411 LKGADVHLECELQGTPPFHVSW-YKDKRELRS---GKKYKIMSENFLTSIHILNVDAADI 7466
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C ++N +D I + P + + I + +G+ + L G S+
Sbjct: 7467 GEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDI--STVVGKEVQLQTTIEGAEPISVV 7524
Query: 607 WVIPGNNVLYQSSR--DKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
W ++ +S N TL+ +V P + G Y C N +G+ +SV
Sbjct: 7525 WFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV 7582
Score = 40.8 bits (94), Expect = 0.018
Identities = 45/170 (26%), Positives = 63/170 (37%), Gaps = 9/170 (5%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG + L C G P V W D +K+R + + L D D+
Sbjct: 7972 VSVGDSASLQCQLAGTPEIGVSWYKGD-TKLRPTTTYK--MHFRNNVATLVFNQVDINDS 8028
Query: 547 GVYHCISSNYDDADILTYRITVVE---PLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
G Y C + N + +TV E P + Q + TV + D C +G
Sbjct: 8029 GEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFD--CAISGSEPI 8086
Query: 604 SISWVIPGNNVLYQSSRDKKVLNN-GTLRILQVTPKDQGYYRCVAANPSG 652
S+SW G + + L+N TL I + G Y C A NP G
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIG 8136
Score = 40.8 bits (94), Expect = 0.018
Identities = 171/849 (20%), Positives = 291/849 (34%), Gaps = 150/849 (17%)
Query: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSI 1812
K + + +G T+ L +GRP P +TW N V G D L N++
Sbjct: 19701 KTLILRAGVTMRLYVPVKGRPPPKITWSKPN--VNLRDRIGLDIKSTDFDTFLRCENVNK 19758
Query: 1813 YDRGFYKCVASNPGGQD--SLLVKIQVIAAPPV---ILEQRRQVIVGTWGESLKLPCTAK 1867
YD G Y N G+ +++VK+ PPV + E + TW + P
Sbjct: 19759 YDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTW----EPPIIDG 19814
Query: 1868 GTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSER 1927
G+P + Y V E K ++ S + + NL + A + G
Sbjct: 19815 GSPIIN-YVVQKRDAERKSWSTVTTEC---SKTSFRVANLEEGKSYFFRVFAENEYG--- 19867
Query: 1928 RVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSK------- 1980
+ P E + G + L + + I W+ P
Sbjct: 19868 ----------IGDPG-ETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRII 19916
Query: 1981 -AVVDQQHRVGSWIHVYPNGSLFIGS--VTEKDSGVYLCVARNKMG------------DD 2025
VVD W V + SL + +TE + A N+ G DD
Sbjct: 19917 GYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDD 19976
Query: 2026 LILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQ 2085
++ + L+ P Y K+ +F++ G P P +SW + + +
Sbjct: 19977 VVAPDLDLKGLPDLC----YLAKE---NSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRV 20029
Query: 2086 ADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQ 2145
+ +S N TL ++ G YT +N G E + + V+ P I
Sbjct: 20030 SVESS--------AVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV-GKPGIPT 20080
Query: 2146 SNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKL 2205
+ EVT + + W P +D S I Y S+ V
Sbjct: 20081 G------------PIKFDEVTAEAM-TLKWAPPKDDGGS-EITNYILEKRDSVNNKWVTC 20126
Query: 2206 LDSGEYVC--VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRA 2263
+ + V R G + +++ +K + GL + V RH FD
Sbjct: 20127 ASAVQKTTFRVTRLHEGME-YTFRVSAENKYGVGEGLKSEPIV-----ARHP---FDV-P 20176
Query: 2264 EGTPSPEVMWIMPDNIFLT---------APYYGSRITVHKNGTLEIRNVRLSD--SADFI 2312
+ P P ++ + D++ LT +P G + + +L + + DF
Sbjct: 20177 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 20236
Query: 2313 CVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVA-----QLGKSTALNCSVDGNPPP 2367
EG E V L + +P+ +E +VA GK +N + +
Sbjct: 20237 VTGLTEGLEYEFRVMAINLAGVGKPSLP---SEPVVALDPIDPPGKPEVINITRNS---V 20290
Query: 2368 EIIWILPNGTRFSNGPQSYQYLIASNG-----------------SFIISKTTREDAGKYR 2410
+IW P ++ G + Y++ +F ++ ++R
Sbjct: 20291 TLIWTEP---KYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFR 20347
Query: 2411 CAARNKVGYI-------EKLVILEIGQKPVIL---TYAPG-TVKGISGESLSLHCVSD-G 2458
A+N G I E ++ + + P I+ T G T+K +G+++ L+ +S G
Sbjct: 20348 IRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIK--AGDTIVLNAISILG 20405
Query: 2459 IPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLIT 2518
P P W+ +G + I + L IK AT D G Y A N G +
Sbjct: 20406 KPLPKSSWS-KAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH 20464
Query: 2519 VPVMIVAYP 2527
V V ++ P
Sbjct: 20465 VKVTVLDVP 20473
Score = 40.8 bits (94), Expect = 0.018
Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 20/145 (13%)
Query: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT---LSIQRV 1713
+++I A D + +G P P I W + D KQ +RV V T L I+
Sbjct: 24320 TYSIQAGEDLKIEIPVIGRPRPNISWVK-----DGEPLKQTTRVNVEETATSTVLHIKEG 24374
Query: 1714 EIQDRGQYLCSASNLFGTDHLHVTLSVVSYP-PRILERRTKEIT-----------VHSGS 1761
D G+Y +A+N GT ++++ V+ P P + R E++ ++G
Sbjct: 24375 NKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGG 24434
Query: 1762 TVELKCRAEGRPSPTVTWILANQTV 1786
E R + T TW + + TV
Sbjct: 24435 CQISNYIVEKRDTTTTTWHMVSATV 24459
Score = 40.8 bits (94), Expect = 0.018
Identities = 28/109 (25%), Positives = 55/109 (50%), Gaps = 9/109 (8%)
Query: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSI 1812
K + + + +T+ L +GRP P V W A + ++++ +Q + T+ LV+ N++
Sbjct: 25115 KVVVLRASATLRLFVTIKGRPEPEVKWEKA-EGILTDRAQIEVTSSFTM---LVIDNVTR 25170
Query: 1813 YDRGFYKCVASNPGGQDSLLVKIQVIAAP--PV---ILEQRRQVIVGTW 1856
+D G Y N G + V ++V+ +P PV I E ++ + +W
Sbjct: 25171 FDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW 25219
Score = 40.8 bits (94), Expect = 0.018
Identities = 77/404 (19%), Positives = 124/404 (30%), Gaps = 82/404 (20%)
Query: 2250 TAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSA 2309
T F C +G P P V W+ + T+ + T +K+ T EI +V+ SD
Sbjct: 32571 TVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKS-TFEISSVQASDEG 32629
Query: 2310 DFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEI 2369
++ V E E + + R T EK V + + P P +
Sbjct: 32630 NYSVVV--ENSEGKQEAEFTLTIQKARVT------EKAVTSPPRVKS--------PEPRV 32673
Query: 2370 IWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIG 2429
P++ + S K+ K K EK+ L +
Sbjct: 32674 -----------KSPEAVK-------SPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVS 32715
Query: 2430 QKPVILTYAPGTVKGISGESLSLHCV--SDGIPKPNIKWTMPSGYVVDRPQINGKYILHD 2487
P I + S E L CV S + + W + + Y
Sbjct: 32716 APPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADG 32772
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY--------------------- 2526
L I T D+G Y+C+ G + + M A+
Sbjct: 32773 TYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTT 32832
Query: 2527 ------------PPRITNRPP-----RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSL 2569
P I+++P + + + + A G P+P W ++
Sbjct: 32833 ESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI 32892
Query: 2570 LSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
+ + L+ I TSDSG+Y CT KN GS
Sbjct: 32893 TQGGKYKLSEDKGGFFLE----IHKTDTSDSGLYTCTVKNSAGS 32932
Score = 40.4 bits (93), Expect = 0.023
Identities = 41/173 (23%), Positives = 72/173 (41%), Gaps = 17/173 (9%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK---LELQMADS 543
V+ G + C G + W D ++R G I G L +
Sbjct: 6282 VIAGESADFECHVTGAQPMRITWS-KDNKEIRP-----GGNYTITCVGNTPHLRILKVGK 6335
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGIP 601
D+G Y C ++N D+ + +++V EP V+ + + + GE++ L C +G P
Sbjct: 6336 GDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQ---GESIQLECKISGSP 6392
Query: 602 DASISWVIPGNNVLYQSSRDKKVLNNGT--LRILQVTPKDQGYYRCVAANPSG 652
+ +SW ++ L++S + N L I + + +D G Y C A N G
Sbjct: 6393 EIKVSW-FRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVG 6444
Score = 40.4 bits (93), Expect = 0.023
Identities = 122/602 (20%), Positives = 206/602 (34%), Gaps = 115/602 (19%)
Query: 1943 IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF 2002
++A+ +K V G + L G P P++ WR K +D R G V L
Sbjct: 18608 LDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWR---KVGIDNVVRKGQVDLVDTMAFLV 18664
Query: 2003 IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKA 2062
I + T DSG Y N G+ + ++V + P + D +V
Sbjct: 18665 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPV-------------SDLKVSDVT 18711
Query: 2063 SGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQ 2122
S +SW+ P+ +D G + Y + E+ +
Sbjct: 18712 KTS--CHVSWAPPE----------NDGGSQVTHY--------------IVEKREADRKTW 18745
Query: 2123 NTLGKDEMKVHLTVITAAP------RIRQSNKTNKRIKAG-DTAVLDCEVTGDPKP---- 2171
+T+ + K V P R+ N+ + VL + +P P
Sbjct: 18746 STVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKL 18805
Query: 2172 ----------KIFWLLPSND--------MISF-----SIDRYTFHA---NGSLTINKVKL 2205
+ WL P D + S+ DR+T ++ + SL + +K
Sbjct: 18806 EVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKE 18865
Query: 2206 LDSGEYVCVARNPSG-----DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFD 2260
++ ARN G + +Y+ PP I L + IKA K +
Sbjct: 18866 GKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKI--LMPEQITIKA----GKKLRIE 18919
Query: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK---NGTLEIRNVRLSDSADFICVARN 2317
G P P W ++ +T+ S + VHK + L I++V DS + A N
Sbjct: 18920 AHVYGKPHPTCKWKKGEDEVVTS----SHLAVHKADSSSILIIKDVTRKDSGYYSLTAEN 18975
Query: 2318 EGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPE-----IIWI 2372
G +++ V++ P + PF+ + A CS+ + P E I
Sbjct: 18976 SSGTDTQKIKVVVMDAPGPP--QPPFD------ISDIDADACSLSWHIPLEDGGSNITNY 19027
Query: 2373 LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILE-IGQK 2431
+ S G + S + K +R A N+ G E L + + Q
Sbjct: 19028 IVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQF 19087
Query: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP-SGYVVDRPQINGKYILHDNGT 2490
P P K ++ C+ +P+ P GY+++R + N + N T
Sbjct: 19088 PF---GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDT 19144
Query: 2491 LV 2492
LV
Sbjct: 19145 LV 19146
Score = 40.4 bits (93), Expect = 0.023
Identities = 74/329 (22%), Positives = 127/329 (38%), Gaps = 48/329 (14%)
Query: 1667 FLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT-LSIQRVEIQDRGQYLCSA 1725
F+P + G P P + W +V + + + + V + T L + V D G+Y +
Sbjct: 22963 FVPIK--GRPTPEVKWGKVDGEI-----RDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTL 23015
Query: 1726 SNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQT 1785
N GT VT+ V+ P + + EIT S S +G S +I+ +
Sbjct: 23016 ENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDG-GSKIKNYIVEKR- 23073
Query: 1786 VVSESSQGSRQAVVT--VDGTLVLHNLSIYDRGFYKCVASNPGG-----QDSLLVKIQVI 1838
E+++ S AVVT + + L +++ A N G Q + +K+ +
Sbjct: 23074 ---EATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 23130
Query: 1839 AAPP---VILEQRRQVIVGTW------GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQF 1889
PP + + R + +W G S + + + S W S+ VK LQ
Sbjct: 23131 PQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKW--SECARVKSLQ- 23187
Query: 1890 TNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG-SERR--VVMLTMEERVTSPRIEAA 1946
I NL + + +A + G S+ R V + ++ V P ++ A
Sbjct: 23188 ------------AVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPA 23235
Query: 1947 SQKRTEVNFGDKLLLNCSATGEPKPQIMW 1975
+ V G L + +G PKP I W
Sbjct: 23236 FSSYS-VQVGQDLKIEVPISGRPKPTITW 23263
Score = 40.0 bits (92), Expect = 0.030
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 14/132 (10%)
Query: 1673 VGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGT- 1731
+G PLP W++ +G D+ + L+I+ +D G+Y +A+N FGT
Sbjct: 20404 LGKPLPKSSWSK--AGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK 20461
Query: 1732 -DHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQ------ 1784
+H+ VT+ V PP +E ++ +T+ E SP ++IL +
Sbjct: 20462 VEHVKVTVLDVPGPPGPVE--ISNVSAEK-ATLTWTPPLEDGGSPIKSYILEKRETSRLL 20518
Query: 1785 -TVVSESSQGSR 1795
TVVSE Q R
Sbjct: 20519 WTVVSEDIQSCR 20530
Score = 40.0 bits (92), Expect = 0.030
Identities = 91/427 (21%), Positives = 161/427 (37%), Gaps = 67/427 (15%)
Query: 2034 RLKPAKIDHKQYFRKQVL--HGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGH 2091
+L+ ++D RK ++ G ++ G P PEI+WS +G + +Q + +
Sbjct: 24018 KLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDK-VQIEKGVN 24076
Query: 2092 RTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVI-TAAPRIRQSNKTN 2150
T+ L + + G Y +N+ G V + V+ T P N
Sbjct: 24077 YTQ---------LSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGP---PQNLAV 24124
Query: 2151 KRIKAGDTAVLDCE---VTGDPKPKIFWLLPSNDMISFSIDRYT-FHANGSLTINKVKLL 2206
K ++ D+A L E + G K K + + D + Y + S T KV+ L
Sbjct: 24125 KEVRK-DSAFLVWEPPIIDGGAKVKNYVI----DKRESTRKAYANVSSKCSKTSFKVENL 24179
Query: 2207 DSGE---YVCVARNPSGDDTKMYKLDVV--SKPPLINGLYTNRTVIKATAVRHSKKHFDC 2261
G + +A N G + +D V ++PP G T V + +A
Sbjct: 24180 TEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSA---------- 24229
Query: 2262 RAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLE-------------IRNVRLSDS 2308
+MW P++ + G + + GT + + +
Sbjct: 24230 --------SLMWEKPEHDG-GSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQE 24280
Query: 2309 ADFICVARNEGGES---VLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNP 2365
F A NE G+S VL V + ++ +P+ + PFN + Q G+ + V G P
Sbjct: 24281 YQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSI-QAGEDLKIEIPVIGRP 24339
Query: 2366 PPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI 2425
P I W+ +G + A++ I + ++D GKY A N G + +
Sbjct: 24340 RPNISWV-KDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLS 24398
Query: 2426 LEIGQKP 2432
+ + +KP
Sbjct: 24399 VIVLEKP 24405
Score = 40.0 bits (92), Expect = 0.030
Identities = 25/85 (29%), Positives = 36/85 (42%), Gaps = 6/85 (7%)
Query: 2539 VTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTS 2598
V R GA+ +L G P P W PD +L A T TL ++N +
Sbjct: 28368 VVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSF------STLTVENCNRN 28421
Query: 2599 DSGIYKCTAKNPLGSDYAATYIQVI 2623
D+G Y T +N GS ++V+
Sbjct: 28422 DAGKYTLTVENNSGSKSITFTVKVL 28446
Score = 40.0 bits (92), Expect = 0.030
Identities = 37/138 (26%), Positives = 58/138 (42%), Gaps = 16/138 (11%)
Query: 2114 EGDYTCYAQNTLGKDEMK-VHLTVITAAPRIRQSNK----TNKRI--KAGDTAVLDCEVT 2166
E ++ A+N G E + +VI P+I + TN+ I KAG +D ++
Sbjct: 28613 EYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPIS 28672
Query: 2167 GDPKPKIFW-----LLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD 2221
G P PK+ W L D +S + T +LT+ DSG Y N +G
Sbjct: 28673 GRPAPKVTWKLEEMRLKETDRVSIT----TTKDRTTLTVKDSMRGDSGRYFLTLENTAGV 28728
Query: 2222 DTKMYKLDVVSKPPLING 2239
T + V+ +P + G
Sbjct: 28729 KTFSVTVVVIGRPGPVTG 28746
Score = 39.7 bits (91), Expect = 0.040
Identities = 44/194 (22%), Positives = 80/194 (41%), Gaps = 20/194 (10%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM--ADSFD 545
L G T + G P P W DG ++ Y +++I + G L + A D
Sbjct: 1469 LEGQTARFDLKVVGRPMPETFWF-HDGQQIVNDYTH---KVVIKEDGTQSLIIVPATPSD 1524
Query: 546 TGVYHCISSNYDDADILTYRITV------VEPL-VEAYQENGIHHTVFIGETLDLPCHST 598
+G + ++ N ++ +TV V+P+ VE + I G L++ +T
Sbjct: 1525 SGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKE----GSRLEMKVRAT 1580
Query: 599 GIPDASISWVIPGNNVL---YQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDF 655
G P+ I W+ + ++ Y R + L+I +D +Y A N +G D
Sbjct: 1581 GNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDT 1640
Query: 656 LIFQVSVKMKGQRP 669
+V+V+++ P
Sbjct: 1641 TRCKVNVEVEFAEP 1654
Score = 39.7 bits (91), Expect = 0.040
Identities = 45/164 (27%), Positives = 66/164 (40%), Gaps = 19/164 (11%)
Query: 1679 TIHWTRVPSGLDLSKRKQNSRVQVLPNGT---LSIQRVEIQDRGQYLCSASNLFGTDHLH 1735
T W R+ D R+ RV L G I+ I G+ A ++ D LH
Sbjct: 17847 TAQWNRINK--DELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILH 17904
Query: 1736 VTLSVVSYPPRI-LERRTKE-ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQG 1793
PP + L+ ++ ITV G T+ + R +GRP P +TW + +V E
Sbjct: 17905 --------PPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVD 17956
Query: 1794 SRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG--QDSLLVKI 1835
Q + V+ L + D G Y A N G Q S +V +
Sbjct: 17957 LIQDLPRVE--LQIKEAVRADHGKYIISAKNSSGHAQGSAIVNV 17998
Score = 39.7 bits (91), Expect = 0.040
Identities = 23/89 (25%), Positives = 42/89 (47%), Gaps = 4/89 (4%)
Query: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSI 1812
K +T+ + T+ L +GRP+P V W + + ++S S + L++ N++
Sbjct: 21868 KVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYT----LLIVGNVNR 21923
Query: 1813 YDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
+D G Y N G S V ++V+ P
Sbjct: 21924 FDSGKYILTVENSSGSKSAFVNVRVLDTP 21952
Score = 39.7 bits (91), Expect = 0.040
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Query: 1741 VSYPPRILERRTKE-ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVV 1799
+ P L+ + K+ I VH+G T L+ G+P P V W + + +++ ++ +
Sbjct: 24702 IDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTI 24761
Query: 1800 TVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
TLV+ + D G Y SN GG S+ + ++V+ P
Sbjct: 24762 Q-KTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRP 24802
Score = 39.3 bits (90), Expect = 0.052
Identities = 44/180 (24%), Positives = 68/180 (37%), Gaps = 9/180 (5%)
Query: 1847 QRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT--LYI 1904
Q Q +V G + G P P V W DG + ++ FS+G L I
Sbjct: 10 QPLQSVVVLEGSTATFEAHISGFPVPEVSW-FRDGQVISTSTLPGVQIS-FSDGRAKLTI 67
Query: 1905 RNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCS 1964
+ ++ G Y AT+ +G L ++ P Q T V G ++ L
Sbjct: 68 PAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMT-VRQGSQVRLQVR 126
Query: 1965 ATGEPKPQI-MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
TG P P + +R ++ ++ +Y SL I +DSG Y A N +G
Sbjct: 127 VTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLY---SLLIAEAYPEDSGTYSVNATNSVG 183
Score = 39.3 bits (90), Expect = 0.052
Identities = 45/174 (25%), Positives = 64/174 (36%), Gaps = 15/174 (8%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
VL G T G P P V W DG + + D KL + ++
Sbjct: 17 VLEGSTATFEAHISGFPVPEVSW-FRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANS 75
Query: 547 GVYHCISSN-----YDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP 601
G Y ++N A++L T V+ Q TV G + L TGIP
Sbjct: 76 GRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQS----MTVRQGSQVRLQVRVTGIP 131
Query: 602 DASISWVIPGNNVLYQSSRDKKVLNNG---TLRILQVTPKDQGYYRCVAANPSG 652
+ + G + QSS D ++ G +L I + P+D G Y A N G
Sbjct: 132 TPVVKFYRDGAEI--QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Score = 39.3 bits (90), Expect = 0.052
Identities = 35/156 (22%), Positives = 57/156 (36%), Gaps = 12/156 (7%)
Query: 501 GDPTPHVDWLLADGSKVRAPYVSEDGRILI---DKSGKLELQMADSFDTGVYHCISSNYD 557
G P + WL D + ED + I D L+++ D+ +G Y C + N
Sbjct: 5073 GSPPISITWLKDD------QILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNES 5126
Query: 558 DADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQ 617
+ + V EP + + T + + L C G P+ + W+ G ++
Sbjct: 5127 GVERCYAFLLVQEPAQIVEKAKSVDVTE--KDPMTLECVVAGTPELKVKWLKDGKQIVPS 5184
Query: 618 SSRDKKVLNN-GTLRILQVTPKDQGYYRCVAANPSG 652
NN + RI V +D G Y N G
Sbjct: 5185 RYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFG 5220
Score = 38.9 bits (89), Expect = 0.068
Identities = 49/186 (26%), Positives = 69/186 (37%), Gaps = 26/186 (13%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD--S 543
TV G V L+C QG + WL A G +++ D SG L++ D
Sbjct: 8356 TVSEGEYVQLSCHVQGSEPIRIQWLKA-GREIKP----SDRCSFSFASGTAVLELRDVAK 8410
Query: 544 FDTGVYHCISSNYDDADILTYRITV-----VEPLVEAYQENGIHHTVFIGE--------- 589
D+G Y C +SN +D ++T+ V P + +G F+ E
Sbjct: 8411 ADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDG--RLFFVSEPQSIRVVEK 8468
Query: 590 -TLDLPCHSTGIPDASISWVIPGNNVLYQSSRD--KKVLNNGTLRILQVTPKDQGYYRCV 646
T G P ++ W L Q R + + L I T D G YRCV
Sbjct: 8469 TTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCV 8528
Query: 647 AANPSG 652
A N G
Sbjct: 8529 AFNEHG 8534
Score = 38.9 bits (89), Expect = 0.068
Identities = 173/848 (20%), Positives = 300/848 (35%), Gaps = 147/848 (17%)
Query: 1674 GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT-LSIQRVEIQDRGQYLCSASNLFGTD 1732
G P P + W + L ++++V + T L I V D G+Y + N G+
Sbjct: 25133 GRPEPEVKWEKAEGILT-----DRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSK 25187
Query: 1733 HLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWI---------LAN 1783
V + V+ P + V L R + S T++W + N
Sbjct: 25188 TAFVNVRVLDSP---------------SAPVNLTIREVKKDSVTLSWEPPLIDGGAKITN 25232
Query: 1784 QTVVSESSQGSRQAVVTVDG-----TLVLHNLSIYDRGFYKCVASNPGG-----QDSLLV 1833
V E + +R+A T+ T + NL +++ +ASN G + + V
Sbjct: 25233 YIV--EKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPV 25290
Query: 1834 KIQVIAAPP---VILEQRRQVIVGTW------GESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
K+ PP +++ R W G S + + S W S T+V
Sbjct: 25291 KVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKW--STCTQV 25348
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLAS-SDRGTYECIATSSTGSERRVVMLTMEERVTSPRI 1943
K L+ T S L + G Y+ +A+ +++G S + V ++ + + P +
Sbjct: 25349 KTLEATISGL---TAGEEYVFRVAAVNEKGR-------SDPRQLGVPVIARDIEI-KPSV 25397
Query: 1944 EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQH-RVGSWIHVYPNGSLF 2002
E V ++L ++ G P+ + WR + + + V S V SL
Sbjct: 25398 ELPFHT-FNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVT---SLS 25453
Query: 2003 IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA-----KIDHKQYFRKQVLHGKDFQ 2057
I +++D G Y N G + + + + +P +ID +
Sbjct: 25454 IKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRID---------------E 25498
Query: 2058 VDCKASGSPVPEISWSLPD---GTMINNAMQADDSGHRTRRYTLFN---NGTLYFNKVGV 2111
V C + ISW+ P+ G I+N + T + + ++ ++
Sbjct: 25499 VSCDSI-----TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTT 25553
Query: 2112 AEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNK-TNKRIKAGDTAVLDCEVTGDPK 2170
E + A+N GK V+ P T K + A + +L
Sbjct: 25554 GSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTML--------- 25604
Query: 2171 PKIFWLLPSNDMISFSIDRYTFHANGSL-------------TINKVKLLDSG---EYVCV 2214
+ W +P ND S I + + S T KV LD G EY
Sbjct: 25605 --VTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVY 25662
Query: 2215 ARNPSGDDTKMYKLDVVSK----PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
A N +G + V P TN T K+ +++ SK H+D A+ T
Sbjct: 25663 AENIAGIGKCSKSCEPVPARDPCDPPGQPEVTNITR-KSVSLKWSKPHYDGGAKITGYIV 25721
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNGTL------EIRNVRLSDSADFICVARNEGGESVL 2324
+PD +L Y + T + L E R V ++AD + G ++
Sbjct: 25722 ERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFR-VFARNAADSVSEPSESTGPIIV 25780
Query: 2325 VVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQ 2384
+E ++ FR + IV + G+ +N + G P P I W +G +
Sbjct: 25781 KDDVEPPRVMMDVKFR----DVIVVKAGEVLKINADIAGRPLPVISW-AKDGIEIEERAR 25835
Query: 2385 SYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKG 2444
+ ++ + R D G+Y +N G V ++ KP P + G
Sbjct: 25836 TEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPG-PPAGPLEING 25894
Query: 2445 ISGESLSL 2452
++ E SL
Sbjct: 25895 LTAEKCSL 25902
Score = 38.9 bits (89), Expect = 0.068
Identities = 23/95 (24%), Positives = 45/95 (47%), Gaps = 12/95 (12%)
Query: 1752 TKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLS 1811
T+ + +G++V+L+ G+P+PT+ W + + A+V V+ T L ++
Sbjct: 26879 TEVVKYRAGTSVKLRAGISGKPAPTIEW-------YKDDKELQTNALVCVENTTDLASIL 26931
Query: 1812 IYD-----RGFYKCVASNPGGQDSLLVKIQVIAAP 1841
I D G Y+ N G S +++Q++ P
Sbjct: 26932 IKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 38.9 bits (89), Expect = 0.068
Identities = 24/87 (27%), Positives = 39/87 (44%), Gaps = 8/87 (9%)
Query: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVD--GTLVLHNLSIYD 1814
V +G+++ L +GRP+PT W +S+ R + T D TL + N + D
Sbjct: 28369 VRAGASIRLFIAYQGRPTPTAVW------SKPDSNLSLRADIHTTDSFSTLTVENCNRND 28422
Query: 1815 RGFYKCVASNPGGQDSLLVKIQVIAAP 1841
G Y N G S+ ++V+ P
Sbjct: 28423 AGKYTLTVENNSGSKSITFTVKVLDTP 28449
Score = 38.9 bits (89), Expect = 0.068
Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 5/72 (6%)
Query: 584 TVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG---TLRILQVTPKDQ 640
T +GE L C G P I W G ++ SR K+ ++G TL ++ +D+
Sbjct: 30543 TTKLGEAAQLSCQIVGRPLPDIKWYRFGKELI--QSRKYKMSSDGRTHTLTVMTEEQEDE 30600
Query: 641 GYYRCVAANPSG 652
G Y C+A N G
Sbjct: 30601 GVYTCIATNEVG 30612
Score = 38.5 bits (88), Expect = 0.088
Identities = 44/190 (23%), Positives = 69/190 (36%), Gaps = 19/190 (10%)
Query: 585 VFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGT--LRILQVTPKDQGY 642
V GET C TG P ++W + N L + S+ +V +G L I+ D G
Sbjct: 1852 VLEGETARFRCRVTGYPQPKVNWYL--NGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGE 1909
Query: 643 YRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSA 702
+ A NP GV + K+K + D + E P H+ EP
Sbjct: 1910 VKVTAENPEGV------IEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEP--------G 1955
Query: 703 LMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPS-ARRIDPQHWAALLE 761
++ EV K + L+R TH + E RR + ++ A+
Sbjct: 1956 KLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITA 2015
Query: 762 KAKKNAMPDK 771
K+ D+
Sbjct: 2016 VELKSRKKDE 2025
Score = 38.5 bits (88), Expect = 0.088
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 6/88 (6%)
Query: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL 2586
PP+I P I + G ++ G P P W+ + ++ T+S H ++ +
Sbjct: 18899 PPKILM--PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVV-TSSHLAVHKADSSSI 18955
Query: 2587 QGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
L+I++ DSG Y TA+N G+D
Sbjct: 18956 ---LIIKDVTRKDSGYYSLTAENSSGTD 18980
Score = 38.1 bits (87), Expect = 0.12
Identities = 79/404 (19%), Positives = 139/404 (34%), Gaps = 45/404 (11%)
Query: 1660 IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT---LSIQRVEIQ 1716
I A +P G P+PT WT+ LD RV + GT L I+ +
Sbjct: 15116 IMAGKTLRIPAVVTGRPVPTKVWTKEEGELD------KDRVVIDNVGTKSELIIKDALRK 15169
Query: 1717 DRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPT 1776
D G+Y+ +A+N G+ + V P +L+ K + + + E
Sbjct: 15170 DHGRYVITATNSCGSKFAAARVEVFDVPGPVLD--LKPVVTNRKMCLLNWSDPEDDGGSE 15227
Query: 1777 VTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQ 1836
+T + + RQ + T + L ++ +A N G +
Sbjct: 15228 ITGFIIERK--DAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGP 15285
Query: 1837 VIAAPPV----------ILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKP 1886
++A P+ E+ + I W E P + G+P +++ KP
Sbjct: 15286 ILAVDPLGPPTSPERLTYTERTKSTITLDWKE----PRSNGGSPIQG--YIIEKRRHDKP 15339
Query: 1887 LQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVML--TMEERVTSPRIE 1944
F L + + NL + A + G + L +++ P I+
Sbjct: 15340 -DFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIK 15398
Query: 1945 AASQKR---TEVNFGDKLLLNCSATGEPKPQIMW-------RLPSKAVVDQQHRVGSWIH 1994
R +V G+ + + TG P P+I W P+ A+ + V
Sbjct: 15399 LRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVS---R 15455
Query: 1995 VYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA 2038
L I +D G Y A N++G +HV + +P+
Sbjct: 15456 SEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPS 15499
Score = 38.1 bits (87), Expect = 0.12
Identities = 37/130 (28%), Positives = 54/130 (41%), Gaps = 19/130 (14%)
Query: 2507 KAQNSVGHTLITVPVMIVAY----PPRITNRPP---RSIVTRTGAAFQLHCVALGVPKPE 2559
KA N +G + ++P+ +V PP I R +I + G + G+P P+
Sbjct: 15370 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 15429
Query: 2560 ITW-------EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
I W E P +L T KE SE + L I D G Y TA N LG
Sbjct: 15430 IEWSKNETVIEKPTDALQIT--KEEVSRSEA---KTELSIPKAVREDKGTYTVTASNRLG 15484
Query: 2613 SDYAATYIQV 2622
S + +++V
Sbjct: 15485 SVFRNVHVEV 15494
Score = 38.1 bits (87), Expect = 0.12
Identities = 59/288 (20%), Positives = 110/288 (38%), Gaps = 41/288 (14%)
Query: 2345 EKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQY-LIASNGSFIISKTTR 2403
++IV G + V G PPP + W + T PQ A + S +I R
Sbjct: 16532 DRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTL----PQEATIETTAISSSMVIKNCQR 16587
Query: 2404 EDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPN 2463
G Y A+N+ G +K +I+++ P + P ++ ES L S P
Sbjct: 16588 SHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVG-TPFLAHNLTNESCKLTWFS-----PE 16641
Query: 2464 IKWTMP-SGYVVDRPQINGKYILHDNGTLVIKEATAYD--RGN---YICKAQNSV--GHT 2515
P + YV+++ + + + T+ + AT +G + A+NS+ G
Sbjct: 16642 DDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPF 16701
Query: 2516 LITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDH----SLLS 2571
+ T +++ P + RP L + +TW P + +++
Sbjct: 16702 VETSEALVIREPITVPERPE-----------DLEVKEVTKNTVTLTWNPPKYDGGSEIIN 16750
Query: 2572 TASKERTHGSEQLH-------LQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
+ R G+E+ H L ++ + D+ Y+ +A N +G
Sbjct: 16751 YVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVG 16798
Score = 38.1 bits (87), Expect = 0.12
Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 2/114 (1%)
Query: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
+KP + + T+ A L G P P + WT+ DL++ + +
Sbjct: 18199 QKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADS 18258
Query: 1706 GTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHS 1759
S+ + + D G+Y+ +A+N G+ + T++V+ P + R K + V S
Sbjct: 18259 SKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPV--RNLKIVDVSS 18310
Score = 38.1 bits (87), Expect = 0.12
Identities = 26/85 (30%), Positives = 36/85 (42%), Gaps = 5/85 (5%)
Query: 2446 SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505
+G SL L G P P +KW G + D I+ + +LV+ YD G Y
Sbjct: 22956 AGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIID---VTSSFTSLVLDNVNRYDSGKYT 23012
Query: 2506 CKAQNSVG--HTLITVPVMIVAYPP 2528
+NS G +TV V+ PP
Sbjct: 23013 LTLENSSGTKSAFVTVRVLDTPSPP 23037
Score = 38.1 bits (87), Expect = 0.12
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 6/88 (6%)
Query: 2536 RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNP 2595
+ IV R G + ++H G P PEITW + E+ QL I N
Sbjct: 24032 KGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLS------IDNC 24085
Query: 2596 QTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+D+G Y +N GS A ++V+
Sbjct: 24086 DRNDAGKYILKLENSSGSKSAFVTVKVL 24113
Score = 38.1 bits (87), Expect = 0.12
Identities = 54/210 (25%), Positives = 85/210 (40%), Gaps = 24/210 (11%)
Query: 1736 VTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSR 1795
VTL+ VS L E H G + L E +P T W ++V+ES +
Sbjct: 24219 VTLTDVSQTSASLMWEKPE---HDGGSRVLGYVVEMQPKGTEKW-----SIVAESKVCN- 24269
Query: 1796 QAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGT 1855
AVVT LS ++ A N G+ V + A + ++ ++ T
Sbjct: 24270 -AVVT--------GLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 24320
Query: 1856 W----GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSD 1911
+ GE LK+ G P+P++ WV DG +K N + S L+I+ D
Sbjct: 24321 YSIQAGEDLKIEIPVIGRPRPNISWV-KDGEPLKQTTRVNVEETATST-VLHIKEGNKDD 24378
Query: 1912 RGTYECIATSSTGSERRVVMLTMEERVTSP 1941
G Y AT+S G+ + + + E+ P
Sbjct: 24379 FGKYTVTATNSAGTATENLSVIVLEKPGPP 24408
Score = 38.1 bits (87), Expect = 0.12
Identities = 19/74 (25%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 1671 EAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFG 1730
+ G PLP I W + G+++ +R + + + L+++ +D GQY+ + N+ G
Sbjct: 25812 DIAGRPLPVISWAK--DGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAG 25869
Query: 1731 TDHLHVTLSVVSYP 1744
T + V V+ P
Sbjct: 25870 TRSVAVNCKVLDKP 25883
Score = 37.7 bits (86), Expect = 0.15
Identities = 47/183 (25%), Positives = 69/183 (37%), Gaps = 14/183 (7%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK--LELQMADS 543
T VG C G P W DG+ + S + RI D K LEL
Sbjct: 3561 TTFVGKAAKFICTVTGTPVIETIWQ-KDGAALSP---SPNWRIS-DAENKHILELSNLTI 3615
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
D GVY C +SN ADI + +++ + + I + + L C
Sbjct: 3616 QDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSA--INKKVHLECQVDEDRKV 3673
Query: 604 SISWVIPGNNVLYQSSRDKKVL---NNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV 660
+++W G + +D K+ TL I KD G Y C A+N +G V
Sbjct: 3674 TVTWSKDGQKL--PPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATV 3731
Query: 661 SVK 663
+V+
Sbjct: 3732 TVR 3734
Score = 37.7 bits (86), Expect = 0.15
Identities = 40/174 (22%), Positives = 64/174 (36%), Gaps = 22/174 (12%)
Query: 490 GGTVG----LNCPGQGDPTPHVDWL-----LADGSKVRAPYVSEDGRILIDKSGKLELQM 540
GG +G L C G V W + G+K + + D L+L
Sbjct: 5810 GGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFS--------DNVCTLQLNS 5861
Query: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
DS D G Y C+++N +D +TV EP ++ + V G+ + G
Sbjct: 5862 LDSSDMGNYTCVAANVAGSDECRAVLTVQEP--PSFVKEPEPLEVLPGKNVTFTSVIRGT 5919
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNN--GTLRILQVTPKDQGYYRCVAANPSG 652
P ++W G L + R + L + + G Y CV +N +G
Sbjct: 5920 PPFKVNW-FRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAG 5972
Score = 37.7 bits (86), Expect = 0.15
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 6/89 (6%)
Query: 1755 ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTV--DGTLVLHNLSI 1812
+TV +G+ +EL G+P P +TW A+ + Q R + V T+ + +
Sbjct: 13700 LTVKAGTKIELPATVTGKPEPKITWTKADMIL----KQDKRITIENVPKKSTVTIVDSKR 13755
Query: 1813 YDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
D G Y A N G+ + +V++ V+ P
Sbjct: 13756 SDTGTYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 37.7 bits (86), Expect = 0.15
Identities = 39/151 (25%), Positives = 60/151 (39%), Gaps = 13/151 (8%)
Query: 2388 YLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAP-------- 2439
Y I S+ F ++ + D ++R A+N G I K G YAP
Sbjct: 28993 YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISK-GSESTGPVTCRDEYAPPKAELDAR 29051
Query: 2440 --GTVKGI-SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEA 2496
G + I +G L L G P+P I WT + +++ +Y T VIK
Sbjct: 29052 LHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYT-GKRATAVIKFC 29110
Query: 2497 TAYDRGNYICKAQNSVGHTLITVPVMIVAYP 2527
D G Y +N+ G ++V V ++ P
Sbjct: 29111 DRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141
Score = 37.4 bits (85), Expect = 0.20
Identities = 25/97 (25%), Positives = 47/97 (48%), Gaps = 5/97 (5%)
Query: 584 TVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKV-LNNGTLRIL--QVTPKDQ 640
TV GE++ L CH +G P +++W + +SS D ++ +G R++ + +D
Sbjct: 953 TVIEGESVTLECHISGYPSPTVTWYREDYQI--ESSIDFQITFQSGIARLMIREAFAEDS 1010
Query: 641 GYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETE 677
G + C A N +G ++V++ + E TE
Sbjct: 1011 GRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047
Score = 37.4 bits (85), Expect = 0.20
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 1656 ASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEI 1715
A T+ A + LP G P P I WT+ + + L + K+ + V T++I +
Sbjct: 13698 AGLTVKAGTKIELPATVTGKPEPKITWTK--ADMILKQDKRITIENVPKKSTVTIVDSKR 13755
Query: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYP 1744
D G Y+ A N+ G V ++V+ P
Sbjct: 13756 SDTGTYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 37.4 bits (85), Expect = 0.20
Identities = 94/438 (21%), Positives = 150/438 (34%), Gaps = 56/438 (12%)
Query: 1773 PSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLL 1832
P T W+ N + + + VV D VL ++ G S P +
Sbjct: 14325 PVGTEKWMRVNSRPIKDLKFKVEEGVVP-DKEYVLRVRAVNAIG-----VSEPSEISENV 14378
Query: 1833 VKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNS 1892
V P + LE +++ GE L +P + P P+V W DG EVK
Sbjct: 14379 VAKDPDCKPTIDLETHDIIVIE--GEKLSIPVPFRAVPVPTVSWH-KDGKEVKASDRLTM 14435
Query: 1893 KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTE 1952
K S L + +D G Y + GS + + ++ +
Sbjct: 14436 KNDHIS-AHLEVPKSVRADAGIYTITLENKLGSATASINV---------KVIGLPGPCKD 14485
Query: 1953 VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD-- 2010
+ D +C T EP P+ P V ++ G ++ S T KD
Sbjct: 14486 IKASDITKSSCKLTWEP-PEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLI 14544
Query: 2011 -SGVYL--CVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
+G Y A NK+G ++ L+ D KQ D VD + +P
Sbjct: 14545 PNGEYFFRVKAVNKVGGG---EYIELKNPVIAQDPKQ--------PPDPPVDVEVH-NPT 14592
Query: 2068 PE---ISWSLP--------DGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGD 2116
E I+W P G +I + ++ R + + L + G+ E +
Sbjct: 14593 AEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLV---PILTYTAKGLEEGKE 14649
Query: 2117 YT--CYAQNTLGKDEMKVHLTVITAAPRIRQSN---KTNKRIKAGDTAVLDCEVTGDPKP 2171
Y A+N G E A I +T+ +K GD LD ++G P P
Sbjct: 14650 YQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYP 14709
Query: 2172 KIFWLLPSNDMISFSIDR 2189
I W+ N ++ I +
Sbjct: 14710 TITWIKDENVIVPEEIKK 14727
Score = 37.4 bits (85), Expect = 0.20
Identities = 29/112 (25%), Positives = 49/112 (43%), Gaps = 18/112 (16%)
Query: 1934 MEERVTSPRI--EAASQKRTEVNFGDKLLLNCSATGEPKPQIMWR-----LPSKAVVDQQ 1986
+++R+ P + +A + + GD L L+ G P P++ W+ P+KA +D
Sbjct: 17209 VKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARID-- 17266
Query: 1987 HRVGSWIHVYPNGS-LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP 2037
V P GS L I + +D G+Y N G + + V + KP
Sbjct: 17267 --------VTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 17310
Score = 37.4 bits (85), Expect = 0.20
Identities = 31/146 (21%), Positives = 61/146 (41%), Gaps = 12/146 (8%)
Query: 2396 FIISKTTREDAGKYRCAARNKVGY-----IEKLVILEIGQKPVILTYAPGTVKGISGESL 2450
+++ + ++R +N+ G E++V+ E QKPV+ G + +G+++
Sbjct: 18160 YMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTI 18219
Query: 2451 SLHCVSDGIPKPNIKWTMPSGYV----VDRPQINGKYILHDNGTLVIKEATAYDRGNYIC 2506
L G P P + WT R +I+ + D+ + +A D G Y+
Sbjct: 18220 RLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTR---ADSSKFSLTKAKRSDGGKYVV 18276
Query: 2507 KAQNSVGHTLITVPVMIVAYPPRITN 2532
A N+ G + V ++ P + N
Sbjct: 18277 TATNTAGSFVAYATVNVLDKPGPVRN 18302
Score = 37.4 bits (85), Expect = 0.20
Identities = 96/436 (22%), Positives = 160/436 (36%), Gaps = 76/436 (17%)
Query: 1943 IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYP-NGSL 2001
++A +K + G + L G P P+I W SK V+ + R+G I + L
Sbjct: 19695 LDADLRKTLILRAGVTMRLYVPVKGRPPPKITW---SKPNVNLRDRIGLDIKSTDFDTFL 19751
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
+V + D+G Y+ N G + V + P G V K
Sbjct: 19752 RCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTP---------------GPPVNVTVK 19796
Query: 2062 ASGSPVPEISWSLP--DG--TMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGD- 2116
++W P DG +IN +Q D+ R T+ + +V EEG
Sbjct: 19797 EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA-ERKSWSTVTTECSKTSFRVANLEEGKS 19855
Query: 2117 --YTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDT--AVLDCEVTGDPKP- 2171
+ +A+N G I +T +KA T V+D +V K
Sbjct: 19856 YFFRVFAENEYG----------------IGDPGETRDAVKASQTPGPVVDLKVRSVSKSS 19899
Query: 2172 -KIFWLLPSND----MISFSIDRYT-------FHANGSLTINKVKLLDSGEYV--CVARN 2217
I W P +D +I + +D T + SL + L + EY A N
Sbjct: 19900 CSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAEN 19959
Query: 2218 PSGDDTK-----MYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVM 2272
+G+ T + + DVV+ + GL + A +S +G P+P V
Sbjct: 19960 ENGEGTPSEITVVARDDVVAPDLDLKGL----PDLCYLAKENSNFRLKIPIKGKPAPSVS 20015
Query: 2273 WIMPDNIFLTAPYYGSRITVHK---NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
W ++ T +R++V N TL + + + SD+ + +N G + ++
Sbjct: 20016 WKKGEDPLAT----DTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIK 20071
Query: 2330 VLEMLRRPTFRNPFNE 2345
V+ PT F+E
Sbjct: 20072 VVGKPGIPTGPIKFDE 20087
Score = 37.4 bits (85), Expect = 0.20
Identities = 31/101 (30%), Positives = 42/101 (41%), Gaps = 4/101 (3%)
Query: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAV--GNPLPTIHWTRVPSGLDLSKRKQNSRVQVL 1703
E PRI TI N+ EA G PLPTI W R ++ S R +
Sbjct: 23621 ELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDF- 23679
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYP 1744
L ++ D GQY+ ASN+ G+ V + V+ P
Sbjct: 23680 -KALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRP 23719
Score = 37.4 bits (85), Expect = 0.20
Identities = 25/93 (26%), Positives = 43/93 (46%), Gaps = 4/93 (4%)
Query: 1849 RQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLA 1908
R+V+V +L+L T KG P+P V W ++G Q + F L I N+
Sbjct: 25114 RKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTM----LVIDNVT 25169
Query: 1909 SSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
D G Y +++GS+ V + + + ++P
Sbjct: 25170 RFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAP 25202
Score = 37.4 bits (85), Expect = 0.20
Identities = 31/129 (24%), Positives = 50/129 (38%), Gaps = 8/129 (6%)
Query: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSN-------KTNKRIKAGDTAVLDCEV 2165
EE + A N GK + I A R+ K ++AG + L
Sbjct: 28322 EEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAY 28381
Query: 2166 TGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKM 2225
G P P W P +++ S D +T + +LT+ D+G+Y N SG +
Sbjct: 28382 QGRPTPTAVWSKPDSNL-SLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSIT 28440
Query: 2226 YKLDVVSKP 2234
+ + V+ P
Sbjct: 28441 FTVKVLDTP 28449
Score = 37.0 bits (84), Expect = 0.26
Identities = 94/431 (21%), Positives = 153/431 (35%), Gaps = 61/431 (14%)
Query: 1935 EERVTSPRIEAASQKRTE--VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW 1992
+ER P + S+ R V G + G P P ++W P D R ++
Sbjct: 26178 KEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKP-----DTDLRTRAY 26232
Query: 1993 IHVYPN-GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVL 2051
+ + SL I + DSG Y +N +L SL L +D
Sbjct: 26233 VDTTDSRTSLTIENANRNDSGKYTLTIQN------VLSAASLTLVVKVLD---------T 26277
Query: 2052 HGKDFQVDCKASGSPVPEISWSLPD---GTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
G + + +SW +P+ G + N + ++ NN K
Sbjct: 26278 PGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYK 26337
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGD 2168
V +EG Y G++E V + T ++ + K + K G T++ V+
Sbjct: 26338 VTNLQEG--AIYYFRVSGENEFGVGIPAET-KEGVKITEKPSPPEKLGVTSISKDSVS-- 26392
Query: 2169 PKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVK-------------LLDSGEYV--C 2213
+ WL P +D S I Y A N VK L ++ EY
Sbjct: 26393 ----LTWLKPEHDGGS-RIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRV 26447
Query: 2214 VARNPSG-DDTKMYKLDVVSK----PPLIN-GLYTNRTVIKATAVRHSKKHFDCRAEGTP 2267
A N +G D + L V+ K PP I+ + + TV S D G P
Sbjct: 26448 FAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAG---SNLKVDIPISGKP 26504
Query: 2268 SPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQ 2327
P+V + D + L A + +N T+ ++ +D+ + A N G + +
Sbjct: 26505 LPKVT-LSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 26563
Query: 2328 LEVLEMLRRPT 2338
+ VL+ PT
Sbjct: 26564 IVVLDRPGPPT 26574
Score = 37.0 bits (84), Expect = 0.26
Identities = 24/82 (29%), Positives = 36/82 (43%), Gaps = 4/82 (4%)
Query: 2535 PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQN 2594
PRS+ G + + C G P P +TW + +LST+++ H + T I +
Sbjct: 32567 PRSMTVYEGESARFSCDTDGEPVPTVTW-LRKGQVLSTSAR---HQVTTTKYKSTFEISS 32622
Query: 2595 PQTSDSGIYKCTAKNPLGSDYA 2616
Q SD G Y +N G A
Sbjct: 32623 VQASDEGNYSVVVENSEGKQEA 32644
Score = 36.6 bits (83), Expect = 0.34
Identities = 34/150 (22%), Positives = 60/150 (40%), Gaps = 10/150 (6%)
Query: 2396 FIISKTTREDAGKYRCAARNKVGYIEKLVI--LEIGQKPVILTYAPG-----TVKGISGE 2448
F++ ++ +R +A N G E VI +EI ++ + + T+ +G
Sbjct: 20733 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGL 20792
Query: 2449 SLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKA 2508
S+ + G P P + WT + + +R I L+I E YD G ++
Sbjct: 20793 SIRIFVPIKGRPAPEVTWTKDNINLKNRANIENT---ESFTLLIIPECNRYDTGKFVMTI 20849
Query: 2509 QNSVGHTLITVPVMIVAYPPRITNRPPRSI 2538
+N G V V ++ P + N P I
Sbjct: 20850 ENPAGKKSGFVNVRVLDTPGPVLNLRPTDI 20879
Score = 36.2 bits (82), Expect = 0.44
Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 1/72 (1%)
Query: 584 TVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQ-VTPKDQGY 642
T+ G+ L + H G P + W + V+ S ++ ++ I++ VT KD GY
Sbjct: 18909 TIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGY 18968
Query: 643 YRCVAANPSGVD 654
Y A N SG D
Sbjct: 18969 YSLTAENSSGTD 18980
Score = 36.2 bits (82), Expect = 0.44
Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 8/108 (7%)
Query: 2520 PVMIVA--YPPRIT-NRPPRSIVT-RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASK 2575
PV I+A PPRI + +S++T + G L G P P ++W+ D +LL A
Sbjct: 19283 PVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK-DGTLLKPAEG 19341
Query: 2576 ERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ L TL + + DSG Y TA+N GS A ++V+
Sbjct: 19342 IKMAMQRNLC---TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL 19386
Score = 35.8 bits (81), Expect = 0.57
Identities = 23/98 (23%), Positives = 41/98 (41%), Gaps = 2/98 (2%)
Query: 557 DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLY 616
D + + I+ E + + ++ + G + C +G P I+W G + +
Sbjct: 1274 DGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKH 1333
Query: 617 QSSRDKKVLNNG--TLRILQVTPKDQGYYRCVAANPSG 652
L +G +LRI V P+D+G Y A+N G
Sbjct: 1334 GERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKG 1371
Score = 35.8 bits (81), Expect = 0.57
Identities = 52/237 (21%), Positives = 88/237 (37%), Gaps = 10/237 (4%)
Query: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
F+C +PS + M D + I K+ L I +V+LSD+ ++ CV R
Sbjct: 11138 FECLV--SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLG 11195
Query: 2319 GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR 2378
E +L V E+ R F E++ G+ L+C + N +++W
Sbjct: 11196 NKEKTSTAKLVVEELPVR--FVKTLEEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIV 11251
Query: 2379 FSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYA 2438
+ +I + I+ DAG Y N +E +++ +
Sbjct: 11252 VEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVEN-ANNLECSSCVKVVEVIRDWLVK 11310
Query: 2439 PGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGK-YILHDNGTLVIK 2494
P + + + ++ PNIKW GY + N K IL D L +K
Sbjct: 11311 PIRDQHVKPKGTAIFACDIAKDTPNIKWF--KGYDEIPAEPNDKTEILRDGNHLYLK 11365
Score = 35.8 bits (81), Expect = 0.57
Identities = 44/165 (26%), Positives = 67/165 (40%), Gaps = 12/165 (7%)
Query: 584 TVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSR--DKKVLNNGTLRILQVTPKDQG 641
TV G ++LP TG P+ I+W + +L Q R + V T+ I+ D G
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKITWT-KADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 13759
Query: 642 YYRCVAANPSGVDFLIFQVSVKMKGQRPLEHD--GETEGSGLDESNPIAHLKEPPGAQLR 699
Y A N G + +V+V K P D T S L NP ++ G+++
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNP---PRDDGGSKIT 13816
Query: 700 TSAL----MEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRFREN 740
+ ++EV SST K N++ L + R EN
Sbjct: 13817 NYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAEN 13861
Score = 35.8 bits (81), Expect = 0.57
Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSN-GTLYIRNLASSDRGTY 1915
G ++ L T G P P+V W DGT +KP + K+ + N TL + ++ D G Y
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWK-KDGTLLKPAE--GIKMAMQRNLCTLELFSVNRKDSGDY 19366
Query: 1916 ECIATSSTGSERRVVMLTMEERVTSP 1941
A +S+GS+ + L + ++ P
Sbjct: 19367 TITAENSSGSKSATIKLKVLDKPGPP 19392
Score = 35.8 bits (81), Expect = 0.57
Identities = 35/142 (24%), Positives = 56/142 (39%), Gaps = 19/142 (13%)
Query: 2320 GESVLVVQLEVLEMLRRPTFR--NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWI----- 2372
GE ++ +E++E P F +V + G S + + G P PE+ W
Sbjct: 20757 GEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNIN 20816
Query: 2373 LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKP 2432
L N N +S+ L II + R D GK+ N G V + + P
Sbjct: 20817 LKNRANIEN-TESFTLL-------IIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP 20868
Query: 2433 -VILTYAPGTVKGISGESLSLH 2453
+L P I+ +S++LH
Sbjct: 20869 GPVLNLRP---TDITKDSVTLH 20887
Score = 35.8 bits (81), Expect = 0.57
Identities = 23/76 (30%), Positives = 32/76 (42%), Gaps = 4/76 (5%)
Query: 2537 SIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQ 2596
+++ + G AF+L G P P + W L TA E + LV ++
Sbjct: 21470 TVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLE----IKIADFSTNLVNKDST 21525
Query: 2597 TSDSGIYKCTAKNPLG 2612
DSG Y TA NP G
Sbjct: 21526 RRDSGAYTLTATNPGG 21541
Score = 35.8 bits (81), Expect = 0.57
Identities = 35/137 (25%), Positives = 52/137 (37%), Gaps = 33/137 (24%)
Query: 2449 SLSLHCVSDGIPKPNIKWTMPSGYVVDRPQING--KYILHDNGTLVIKEATAYDRGNYIC 2506
+L L G P P +KW G +D+ I Y L L++ +D G YI
Sbjct: 21877 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL-----LIVGNVNRFDSGKYIL 21931
Query: 2507 KAQNSVGHTLITVPVMIVAYPPRITNRPPRSI----VTRTGAAFQLHCVALGVPKPEITW 2562
+NS G V V ++ P PP+ + VT+T +TW
Sbjct: 21932 TVENSSGSKSAFVNVRVLDTP-----GPPQDLKVKEVTKTSVT--------------LTW 21972
Query: 2563 EMPDHSLLSTASKERTH 2579
+ P LL SK + +
Sbjct: 21973 DPP---LLDGGSKIKNY 21986
Score = 35.8 bits (81), Expect = 0.57
Identities = 45/167 (26%), Positives = 67/167 (40%), Gaps = 28/167 (16%)
Query: 2300 IRNVRLSDSADFICVARNEGGES---VLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTA 2356
I N+ + F VA NE G S L V + +++ P + F+ V Q+G+
Sbjct: 23190 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSV-QVGQDLK 23248
Query: 2357 LNCSVDGNPPPEIIWI-----LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRC 2411
+ + G P P I W L TR N S S I +T ++D G+Y
Sbjct: 23249 IEVPISGRPKPTITWTKDGLPLKQTTRI-NVTDSLDLTTLS-----IKETHKDDGGQYGI 23302
Query: 2412 AARNKVGYIEKLVILEIGQKPVILTYAPGTVKG------ISGESLSL 2452
N VG +K +EI + P KG +S ES++L
Sbjct: 23303 TVANVVG--QKTASIEI-----VTLDKPDPPKGPVKFDDVSAESITL 23342
Score = 35.8 bits (81), Expect = 0.57
Identities = 21/86 (24%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 1660 IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQ-VLPNGTLSIQRVEIQDR 1718
+ A L + G P+P + W++ G +L + ++ + TL ++ D
Sbjct: 24719 VHAGETFVLEADIRGKPIPDVVWSK--DGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 24776
Query: 1719 GQYLCSASNLFGTDHLHVTLSVVSYP 1744
GQY+ SN+ GT + +T+ V+ P
Sbjct: 24777 GQYILKLSNVGGTKSIPITVKVLDRP 24802
Score = 35.8 bits (81), Expect = 0.57
Identities = 36/148 (24%), Positives = 59/148 (39%), Gaps = 19/148 (12%)
Query: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT---LSIQRV 1713
+F + A + G P T++W + D K+ +RV V + T LSI+
Sbjct: 25403 TFNVKAREQLKIDVPFKGRPQATVNWRK-----DGQTLKETTRVNVSSSKTVTSLSIKEA 25457
Query: 1714 EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPP-----RILERRTKEITV------HSGST 1762
+D G Y SN G+ + +T+ V+ P RI E IT+ + G
Sbjct: 25458 SKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGC 25517
Query: 1763 VELKCRAEGRPSPTVTWILANQTVVSES 1790
E + + + TW + +Q V S
Sbjct: 25518 QISNYIVEKKETTSTTWHIVSQAVARTS 25545
Score = 35.4 bits (80), Expect = 0.75
Identities = 36/149 (24%), Positives = 57/149 (38%), Gaps = 6/149 (4%)
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGT-LVIKEATAYDRGNYICKAQNSVGHTL 2516
G P P +W +G ++R Y DN LVI++ TA D + + KA N G T
Sbjct: 2103 GKPDPECEW-YKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETS 2161
Query: 2517 ITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKE 2576
+++ A + + +V + P ++ W D + K
Sbjct: 2162 SHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKW-YKDGMEVHEGDKY 2220
Query: 2577 RTHGSEQLHLQGTLVIQNPQTSDSGIYKC 2605
R H ++H L I TSD+ Y C
Sbjct: 2221 RMHSDRKVHFLSILTI---DTSDAEDYSC 2246
Score = 35.4 bits (80), Expect = 0.75
Identities = 26/97 (26%), Positives = 45/97 (46%), Gaps = 10/97 (10%)
Query: 1660 IPANSDAFLPCEAVGNPLPTIHWTR------VPSGLDLSKRKQNSRVQVLPNGTLSIQRV 1713
+ A +P + G P+P I W++ P+ +++ SR + LSI +
Sbjct: 15410 VKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTE--LSIPKA 15467
Query: 1714 EIQDRGQYLCSASNLFGT--DHLHVTLSVVSYPPRIL 1748
+D+G Y +ASN G+ ++HV + PPR L
Sbjct: 15468 VREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNL 15504
Score = 35.4 bits (80), Expect = 0.75
Identities = 22/85 (25%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916
G +LK+ G P P V + DG +K N+++ N T+ ++ ++D G YE
Sbjct: 26491 GSNLKVDIPISGKPLPKVT-LSRDGVPLKATMRFNTEITA-ENLTINLKESVTADAGRYE 26548
Query: 1917 CIATSSTGSERRVVMLTMEERVTSP 1941
A +S+G+ + + + + +R P
Sbjct: 26549 ITAANSSGTTKAFINIVVLDRPGPP 26573
Score = 35.4 bits (80), Expect = 0.75
Identities = 40/182 (21%), Positives = 68/182 (37%), Gaps = 21/182 (11%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS-GKLELQMADSF 544
T VG V P PHV W + G K++ + DK +L + +
Sbjct: 31700 TAYVGENVRFGVTITVHPEPHVTWYKS-GQKIKPGDNDKKYTFESDKGLYQLTINSVTTD 31758
Query: 545 DTGVYHCISSNYDDADILTYRITV----------VEPLVEAYQENGIHHTVFIGETLDLP 594
D Y ++ N D ++TV + P+ + N G+++
Sbjct: 31759 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE---GQSVCFE 31815
Query: 595 CHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG----TLRILQVTPKDQGYYRCVAANP 650
+GIP ++ W G + + ++++ G L I P+D GYYR A N
Sbjct: 31816 IRVSGIPPPTLKWEKDGQPL--SLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 31873
Query: 651 SG 652
+G
Sbjct: 31874 AG 31875
Score = 35.0 bits (79), Expect = 0.97
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 5/85 (5%)
Query: 2430 QKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYI-LHDN 2488
QKP I+ Y P V+ + GE+ C G P+P + W + + + +Y +H
Sbjct: 1839 QKPDIVLY-PEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIH-- 1895
Query: 2489 GTLVIKEATAYDRGNYICKAQNSVG 2513
L I + +YD G A+N G
Sbjct: 1896 -YLDIVDCKSYDTGEVKVTAENPEG 1919
Score = 35.0 bits (79), Expect = 0.97
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 6/97 (6%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT-LYIRNLASSDRGTY 1915
G++L+L KG P P V W D T +++ + G+ L IRN A D G Y
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAP-----TKARIDVTPVGSKLEIRNAAHEDGGIY 17287
Query: 1916 ECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTE 1952
+ GS+ V + + ++ PR S+ R +
Sbjct: 17288 SLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKD 17324
Score = 35.0 bits (79), Expect = 0.97
Identities = 68/295 (23%), Positives = 113/295 (38%), Gaps = 48/295 (16%)
Query: 2291 TVHKNGTLEIRNVRLSDSADFICVARNEGGESV---LVVQLEVLEMLRRPTFRNPFNEKI 2347
+V K+ +L + ++ F ARN G S+ E E L P P E+I
Sbjct: 18851 SVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMP--EQI 18908
Query: 2348 VAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG 2407
+ GK + V G P P W ++ + + S+ II TR+D+G
Sbjct: 18909 TIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAV-HKADSSSILIIKDVTRKDSG 18967
Query: 2408 KYRCAARNKVGYIE---KLVILEIGQKPVILTYAPGTVKGISGE--SLSLHC-VSDGIPK 2461
Y A N G K+V+++ P P + I + SLS H + DG
Sbjct: 18968 YYSLTAENSSGTDTQKIKVVVMDAPGPP----QPPFDISDIDADACSLSWHIPLEDG--G 19021
Query: 2462 PNIKWTMPSGYVVDRPQIN-GKYILHDNGTLVIKEATAYDRGNYI--------CKAQNSV 2512
NI + Y+V++ ++ G ++ L T+ G I +A+N
Sbjct: 19022 SNI-----TNYIVEKCDVSRGDWVT----ALASVTKTSCRVGKLIPGQEYIFRVRAENRF 19072
Query: 2513 G-HTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPD 2566
G +T P M+ +P + + P + VT+ C+ + W+ PD
Sbjct: 19073 GISEPLTSPKMVAQFPFGVPSEPKNARVTKVNK----DCIF-------VAWDRPD 19116
Score = 35.0 bits (79), Expect = 0.97
Identities = 23/87 (26%), Positives = 40/87 (45%), Gaps = 4/87 (4%)
Query: 1659 TIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN-GTLSIQRVEIQD 1717
T+ A ++ L G P+PT+ W + + L K + ++ + N TL + V +D
Sbjct: 19306 TVKAGTNVCLDATVFGKPMPTVSWKKDGT---LLKPAEGIKMAMQRNLCTLELFSVNRKD 19362
Query: 1718 RGQYLCSASNLFGTDHLHVTLSVVSYP 1744
G Y +A N G+ + L V+ P
Sbjct: 19363 SGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 35.0 bits (79), Expect = 0.97
Identities = 40/180 (22%), Positives = 72/180 (40%), Gaps = 23/180 (12%)
Query: 1770 EGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG-- 1827
E R P W+ AN + + E+ TV G L + Y+ ++ +A N G
Sbjct: 21394 EKRDLPNGRWLKANFSNILENE-------FTVSG---LTEDAAYE---FRVIAKNAAGAI 21440
Query: 1828 ------QDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
D++ + V A + + + ++ GE+ +L G P P++ W DG
Sbjct: 21441 SPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEW-SKDG 21499
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
E++ K+ FS L ++ D G Y AT+ G + + + + +R P
Sbjct: 21500 KELEGTAKLEIKIADFST-NLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPP 21558
Score = 35.0 bits (79), Expect = 0.97
Identities = 51/204 (25%), Positives = 81/204 (39%), Gaps = 38/204 (18%)
Query: 2050 VLH-GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
V+H G+ F+VD G P+P I W D + N A S T F +
Sbjct: 22554 VVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKS-------TDFATSLSVKDA 22606
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGD 2168
V V + G+Y A+N G+ + V++ V+ R + +G TA
Sbjct: 22607 VRV-DSGNYILKAKNVAGERSVTVNVKVLD-----RPGPPEGPVVISGVTA--------- 22651
Query: 2169 PKPKIFWLLP----SNDMISFSIDR--------YTFHAN-GSLTINKVKLLDSGEYV--C 2213
K + W P +D+I++ ++R AN +L+ KLL+ EY
Sbjct: 22652 EKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRI 22711
Query: 2214 VARNPSGDDTKMYKLDVVSKPPLI 2237
+A N G + VV+K P +
Sbjct: 22712 MAVNKYGVGEPLESEPVVAKNPFV 22735
Score = 35.0 bits (79), Expect = 0.97
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 3/82 (3%)
Query: 584 TVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLN--NGTLRILQVTPKDQG 641
TV+ GE+ C + G P +++W+ G VL S+R + T I V D+G
Sbjct: 32571 TVYEGESARFSCDTDGEPVPTVTWLRKG-QVLSTSARHQVTTTKYKSTFEISSVQASDEG 32629
Query: 642 YYRCVAANPSGVDFLIFQVSVK 663
Y V N G F ++++
Sbjct: 32630 NYSVVVENSEGKQEAEFTLTIQ 32651
Score = 34.7 bits (78), Expect = 1.3
Identities = 37/140 (26%), Positives = 60/140 (42%), Gaps = 23/140 (16%)
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGD 2168
V ++G YTC ++ E+++ I RI+ N + +A +CEV+ D
Sbjct: 8806 VRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRIQ-----NIVVSEHQSATFECEVSFD 8860
Query: 2169 PKPKIFWLLPSNDMISFSIDRYTFHANGS---LTINKVKLLDSGEYVCVAR-NPSGD--- 2221
++ P+ S +Y F +G +TI+ V D G Y +AR P G+
Sbjct: 8861 DAIVTWYKGPTELTES---QKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARS 8917
Query: 2222 ------DTKMYKLDVVSKPP 2235
TK KL++ KPP
Sbjct: 8918 TAELYLTTKEIKLEL--KPP 8935
Score = 34.7 bits (78), Expect = 1.3
Identities = 28/121 (23%), Positives = 49/121 (40%), Gaps = 3/121 (2%)
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQV-IVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
AS P + + AP + L+ + + G ++LP T G P+P + W +D
Sbjct: 13669 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 13728
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
+ + T + T+ I + SD GTY A + G VV + + ++
Sbjct: 13729 MILKQDKRITIEN--VPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGP 13786
Query: 1941 P 1941
P
Sbjct: 13787 P 13787
Score = 34.7 bits (78), Expect = 1.3
Identities = 37/151 (24%), Positives = 57/151 (37%), Gaps = 29/151 (19%)
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTR--FSNG----PQSYQYLIASNGS-FIIS 2399
+V + G + + G P P+ W + +G P+ Q A N S II
Sbjct: 15820 LVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIP 15879
Query: 2400 KTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGI 2459
+ R GKY A+NK G + V + PG K L + ++ G
Sbjct: 15880 ECKRSHTGKYSITAKNKAGQ-------KTANCRVKVMDVPGPPK-----DLKVSDITRG- 15926
Query: 2460 PKPNIKWTMP--------SGYVVDRPQINGK 2482
+ W MP GYV+++ I+GK
Sbjct: 15927 -SCRLSWKMPDDDGGDRIKGYVIEKRTIDGK 15956
Score = 34.7 bits (78), Expect = 1.3
Identities = 30/99 (30%), Positives = 40/99 (40%), Gaps = 8/99 (8%)
Query: 2527 PPRIT-NRPPRSIVT-RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQL 2584
PP I + R +VT R +L G P PE+ W L AS E T
Sbjct: 21857 PPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSS---- 21912
Query: 2585 HLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L++ N DSG Y T +N GS A ++V+
Sbjct: 21913 --YTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVL 21949
Score = 34.3 bits (77), Expect = 1.7
Identities = 58/258 (22%), Positives = 98/258 (37%), Gaps = 25/258 (9%)
Query: 1695 KQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKE 1754
+QN+ VQ L G R+ ++ T V ++ P R + KE
Sbjct: 16672 RQNATVQGLIQGKAYFFRIAAENS----IGMGPFVETSEALVIREPITVPERPEDLEVKE 16727
Query: 1755 ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTL----VLHNL 1810
+T ++ + + +G S + ++L ++ + +E VT D L + L
Sbjct: 16728 VTKNTVTLTWNPPKYDGG-SEIINYVLESRLIGTEKFHK-----VTNDNLLSRKYTVKGL 16781
Query: 1811 SIYDRGFYKCVASNPGGQDSLLVKIQVIA-----APPVILEQRRQVIVGTWGESLKLPCT 1865
D Y+ A N GQ + I APP + R + GE+ L
Sbjct: 16782 KEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGR 16841
Query: 1866 AKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLAS--SDRGTYECIATSST 1923
G P+P V W D +V T+ K + TL + + + SD G Y + +ST
Sbjct: 16842 YSGKPKPKVSW-FKDEADVLEDDRTHIKT---TPATLALEKIKAKRSDSGKYCVVVENST 16897
Query: 1924 GSERRVVMLTMEERVTSP 1941
GS + + + +R P
Sbjct: 16898 GSRKGFCQVNVVDRPGPP 16915
Score = 34.3 bits (77), Expect = 1.7
Identities = 22/92 (23%), Positives = 39/92 (42%), Gaps = 8/92 (8%)
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYIC 2506
G++L L + G+P P + W + +I+ + L I+ A D G Y
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARID---VTPVGSKLEIRNAAHEDGGIYSL 17289
Query: 2507 KAQNSVGHTLITVPVMIVAYPPRITNRPPRSI 2538
+N G ++V V+++ P PPR +
Sbjct: 17290 TVENPAGSKTVSVKVLVLDKP-----GPPRDL 17316
Score = 34.3 bits (77), Expect = 1.7
Identities = 32/152 (21%), Positives = 58/152 (38%), Gaps = 8/152 (5%)
Query: 2307 DSADFICVARNEGGESVLVVQLEVLEMLRRPT------FRNPFNEKIVAQLGKSTALNCS 2360
D +F +ARN G Q + M R F + + ++ + G+S +
Sbjct: 27922 DRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKAL 27981
Query: 2361 VDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYI 2420
V G P P + W +G + + S + TR+ G Y A+N G
Sbjct: 27982 VQGRPVPRVTW-FKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSA 28040
Query: 2421 EKLVILEIGQKPVILTYAPGTVKGISGESLSL 2452
+ + +++ P + P I+GE ++L
Sbjct: 28041 KAEIKVKVQDTPGKVV-GPIRFTNITGEKMTL 28071
Score = 34.3 bits (77), Expect = 1.7
Identities = 31/112 (27%), Positives = 45/112 (40%), Gaps = 12/112 (10%)
Query: 1755 ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG--TLVLHNLSI 1812
IT +GS + GRP+P VTW L + + R ++ T TL + +
Sbjct: 28657 ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRL----KETDRVSITTTKDRTTLTVKDSMR 28712
Query: 1813 YDRGFYKCVASNPGGQDSLLVKIQVIAAP-PV-----ILEQRRQVIVGTWGE 1858
D G Y N G + V + VI P PV + + V +WGE
Sbjct: 28713 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGE 28764
Score = 34.3 bits (77), Expect = 1.7
Identities = 23/86 (26%), Positives = 36/86 (41%), Gaps = 4/86 (4%)
Query: 2538 IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQT 2597
+ R G+ L G P+P+I W D L + ++ T VI+
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKR----ATAVIKFCDR 29112
Query: 2598 SDSGIYKCTAKNPLGSDYAATYIQVI 2623
SDSG Y T KN G+ + ++V+
Sbjct: 29113 SDSGKYTLTVKNASGTKAVSVMVKVL 29138
Score = 33.9 bits (76), Expect = 2.2
Identities = 43/187 (22%), Positives = 70/187 (37%), Gaps = 12/187 (6%)
Query: 482 KLEHTVLV--GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
KLE + L+ G L C G P + W D + S+ ++ + L L
Sbjct: 4304 KLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKES---SKHRMSFVESTAVLRLT 4360
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
D+G Y C + N +D + + V E + I V + L G
Sbjct: 4361 DVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIE--VLKEYDVMLLAEVAG 4418
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNG---TLRILQVTPKDQGYYRCVAANPSGVDFL 656
P I+W +N + +S R K +L+IL+ D G Y+C N G
Sbjct: 4419 TPPFEITWF--KDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSIC 4476
Query: 657 IFQVSVK 663
+V+++
Sbjct: 4477 SARVTLR 4483
Score = 33.9 bits (76), Expect = 2.2
Identities = 27/118 (22%), Positives = 47/118 (39%), Gaps = 14/118 (11%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC 1767
L+I V +D+GQY C +L + L + + + RI + ++ H +T E +
Sbjct: 8801 LTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRI---QNIVVSEHQSATFECEV 8857
Query: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGT---LVLHNLSIYDRGFYKCVA 1822
+ VTW + R DG + +HN++ D G Y +A
Sbjct: 8858 SFD---DAIVTWYKGPTELTESQKYNFRN-----DGRCHYMTIHNVTPDDEGVYSVIA 8907
Score = 33.9 bits (76), Expect = 2.2
Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 8/95 (8%)
Query: 1932 LTMEERVTSPRIEAASQKRTEVNF--GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRV 1989
+ +EE++ +P I+ + R +N G L L G P P++ W VD + R
Sbjct: 22931 IIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW-----GKVDGEIRD 22985
Query: 1990 GSWIHVYPN-GSLFIGSVTEKDSGVYLCVARNKMG 2023
+ I V + SL + +V DSG Y N G
Sbjct: 22986 AAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSG 23020
Score = 33.9 bits (76), Expect = 2.2
Identities = 21/82 (25%), Positives = 32/82 (39%), Gaps = 3/82 (3%)
Query: 2446 SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505
+G S+ L G P P W+ P + R I + TL ++ D G Y
Sbjct: 28371 AGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADI---HTTDSFSTLTVENCNRNDAGKYT 28427
Query: 2506 CKAQNSVGHTLITVPVMIVAYP 2527
+N+ G IT V ++ P
Sbjct: 28428 LTVENNSGSKSITFTVKVLDTP 28449
Score = 33.9 bits (76), Expect = 2.2
Identities = 25/87 (28%), Positives = 35/87 (40%), Gaps = 3/87 (3%)
Query: 2441 TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD 2500
TV +G SL L G P P I W+ + R I+ L++ + YD
Sbjct: 29455 TVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIID---TTESYSLLIVDKVNRYD 29511
Query: 2501 RGNYICKAQNSVGHTLITVPVMIVAYP 2527
G Y +A+N G TV V + P
Sbjct: 29512 AGKYTIEAENQSGKKSATVLVKVYDTP 29538
Score = 33.9 bits (76), Expect = 2.2
Identities = 48/228 (21%), Positives = 88/228 (38%), Gaps = 22/228 (9%)
Query: 454 SDAQITLPRAEMRPVKHKWTMISRDNNTK--LEHTVLVGGTVGLNCPGQGDPTPHVDWLL 511
++ ++ PR +K K T K + T +G L+C G P P + W
Sbjct: 30509 NETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYR 30568
Query: 512 ADGSKV--RAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVV 569
+ R +S DGR + L + + D GVY CI++N + ++ T ++
Sbjct: 30569 FGKELIQSRKYKMSSDGR-----THTLTVMTEEQEDEGVYTCIATN-EVGEVETSSKLLL 30622
Query: 570 EPLVEAYQENGIHHTVF--IGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNN 627
+ + + + + +G TL L G P +++W G +L S + +
Sbjct: 30623 QATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQNS---ENITIE 30678
Query: 628 GTLRILQVTPKD------QGYYRCVAANPSGVDFLIFQVSVKMKGQRP 669
T + K+ G Y+ +N G I V ++ K +P
Sbjct: 30679 NTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKP 30726
Score = 33.9 bits (76), Expect = 2.2
Identities = 51/180 (28%), Positives = 69/180 (38%), Gaps = 36/180 (20%)
Query: 495 LNCPGQGDPTPHVDW------LLADGSKVRAPYVSEDGRILIDKSGKLELQMAD--SFDT 546
L C G P P V W ++ADG K R I K G +L +A D
Sbjct: 30947 LVCKVTGHPKPIVKWYRQGKEIIADGLKYR---------IQEFKGGYHQLIIASVTDDDA 30997
Query: 547 GVYHCISSNYDDADILTYRITVVEP----LVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
VY ++N + T + V P L + + G H + GE + + +G PD
Sbjct: 30998 TVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALR-GEVVSIKIPFSGKPD 31056
Query: 603 ASISWV----IPGNNVLYQ----SSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
I+W + NN YQ S V NG R KD G+Y A N G+D
Sbjct: 31057 PVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVER------KDAGFYVVCAKNRFGID 31110
Score = 33.5 bits (75), Expect = 2.8
Identities = 41/158 (25%), Positives = 65/158 (41%), Gaps = 15/158 (9%)
Query: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS---LTINKVKLLDSGEYV 2212
G +A+ +C V+ P I + I S ++ F A+G L I V+L D+GEY
Sbjct: 11133 GSSAIFECLVS--PSTAITTWMKDGSNIRES-PKHRFIADGKDRKLHIIDVQLSDAGEYT 11189
Query: 2213 CVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVM 2272
CV R + + T KL VV + P+ + + T V+ + C E +V+
Sbjct: 11190 CVLRLGNKEKTSTAKL-VVEELPV---RFVKTLEEEVTVVKGQPLYLSC--ELNKERDVV 11243
Query: 2273 WIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSAD 2310
W I + P RI G + + +D D
Sbjct: 11244 WRKDGKIVVEKP---GRIVPGVIGLMRALTINDADDTD 11278
Score = 33.5 bits (75), Expect = 2.8
Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 1953 VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSG 2012
V G K+ L + TG+P+P+I W + ++ Q R+ + +V ++ I D+G
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITW-TKADMILKQDKRI-TIENVPKKSTVTIVDSKRSDTG 13759
Query: 2013 VYLCVARNKMGDDLILMHVSLRLKP 2037
Y+ A N G ++ V++ KP
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 33.5 bits (75), Expect = 2.8
Identities = 29/116 (25%), Positives = 48/116 (41%), Gaps = 11/116 (9%)
Query: 1736 VTLSVVSYPPRI-LERRTKE-ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQG 1793
VT++ PP + L+ K I + +G T+ + GRP PT W E
Sbjct: 15093 VTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVW------TKEEGELD 15146
Query: 1794 SRQAVVTVDGT---LVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILE 1846
+ V+ GT L++ + D G Y A+N G +++V P +L+
Sbjct: 15147 KDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLD 15202
Score = 33.5 bits (75), Expect = 2.8
Identities = 25/89 (28%), Positives = 34/89 (38%), Gaps = 6/89 (6%)
Query: 1755 ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVT--VDGTLVLHNLSI 1812
+ V +G+TV G P PT W T SE V T L + N
Sbjct: 17520 LVVKAGTTVRFPAIIRGVPVPTAKW----TTDGSEIKTDEHYTVETDNFSSVLTIKNCLR 17575
Query: 1813 YDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
D G Y+ SN G ++ V + V+ P
Sbjct: 17576 RDTGEYQITVSNAAGSKTVAVHLTVLDVP 17604
Score = 33.5 bits (75), Expect = 2.8
Identities = 34/130 (26%), Positives = 53/130 (40%), Gaps = 12/130 (9%)
Query: 552 ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI--GETLDLPCHSTGIPDASISWVI 609
IS + +D +T R V P ++ + TV + GE L +G P ++ W
Sbjct: 21440 ISPPSEPSDAITCRDDVEAPKIKV--DVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 21497
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQ-VTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQR 668
G + + + K+ + T + + T +D G Y A NP G IF V V
Sbjct: 21498 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKV------ 21551
Query: 669 PLEHDGETEG 678
L+ G EG
Sbjct: 21552 -LDRPGPPEG 21560
Score = 33.5 bits (75), Expect = 2.8
Identities = 37/155 (23%), Positives = 61/155 (39%), Gaps = 22/155 (14%)
Query: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP---NGTLSIQRV 1713
+FT+ A D + +G P P + W + D KQ +RV N L+I+
Sbjct: 22156 TFTVLAGEDLKVDVPFIGRPTPAVTWHK-----DNVPLKQTTRVNAESTENNSLLTIKDA 22210
Query: 1714 EIQDRGQYLCSASNLFGTDHLHVTLSVVSYP-PRILERRTKEITVHS------------G 1760
+D G Y+ +N G + + V+ P P + E+T S G
Sbjct: 22211 CREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGG 22270
Query: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSR 1795
S++ E R + T TW + + TV + + R
Sbjct: 22271 SSIN-NYIVEKRDTSTTTWQIVSATVARTTIKACR 22304
Score = 33.5 bits (75), Expect = 2.8
Identities = 88/421 (20%), Positives = 155/421 (36%), Gaps = 58/421 (13%)
Query: 1838 IAAPPVILE-QRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFL 1896
+ AP + L+ + R++I G SL+L KG P P V W DG E++ +
Sbjct: 22937 LEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDG-EIRDAAIID---VT 22992
Query: 1897 FSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP---RIEAASQKRTEV 1953
S +L + N+ D G Y +S+G++ V + + + + P ++ ++ +
Sbjct: 22993 SSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSI 23052
Query: 1954 NFGDKLLLNCSATGE--PKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT-EKD 2010
+ LL S + + R AVV H+ I G + VT E +
Sbjct: 23053 TWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENE 23112
Query: 2011 SGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEI 2070
G+ L + D + + V P KI R V +
Sbjct: 23113 YGIGLPA---QTADPIKVAEVP--QPPGKITVDDVTRNSV------------------SL 23149
Query: 2071 SWSLPD---GTMINN---AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNT 2124
SW+ P+ G+ I MQA S + + + EE + A N
Sbjct: 23150 SWTKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNE 23208
Query: 2125 LGKDEMKVHLTVITAAPRIRQSNK----TNKRIKAGDTAVLDCEVTGDPKPKIFWL---L 2177
G+ + + I A + + + ++ ++ G ++ ++G PKP I W L
Sbjct: 23209 KGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGL 23268
Query: 2178 PSNDM----ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK 2233
P ++ S+D T L+I + D G+Y N G T ++ + K
Sbjct: 23269 PLKQTTRINVTDSLDLTT------LSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 23322
Query: 2234 P 2234
P
Sbjct: 23323 P 23323
Score = 33.5 bits (75), Expect = 2.8
Identities = 22/87 (25%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 2446 SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505
+G S ++ G P PN+ W+ P + R ++ +L I+ A D G Y
Sbjct: 26200 AGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVD---TTDSRTSLTIENANRNDSGKYT 26256
Query: 2506 CKAQNSVGHTLITVPVMIVAYPPRITN 2532
QN + +T+ V ++ P TN
Sbjct: 26257 LTIQNVLSAASLTLVVKVLDTPGPPTN 26283
Score = 33.1 bits (74), Expect = 3.7
Identities = 30/127 (23%), Positives = 51/127 (40%), Gaps = 6/127 (4%)
Query: 529 LIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEP--LVEAYQENGIHHTVF 586
L++ + L + D G Y C +SN D + ++ V EP ++ + + I V
Sbjct: 7262 LVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRI---VK 7318
Query: 587 IGETLDLPCHSTGIPDASISWVIPGNNVLYQSS-RDKKVLNNGTLRILQVTPKDQGYYRC 645
E C G P+ + W + S R V + L + ++ +D G Y C
Sbjct: 7319 QDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTC 7378
Query: 646 VAANPSG 652
A N +G
Sbjct: 7379 EAHNAAG 7385
Score = 33.1 bits (74), Expect = 3.7
Identities = 64/266 (24%), Positives = 101/266 (37%), Gaps = 33/266 (12%)
Query: 2157 DTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVK---LLDSGEYV- 2212
D L CEV+ D K W +++ +Y+ A+G I K+K L D GEYV
Sbjct: 11678 DEITLKCEVSKDVPVK--WFKDGEEIVPSP--KYSIKADGLRRILKIKKADLKDKGEYVC 11733
Query: 2213 -CVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEV 2271
C + T +L V KP LY + TA HF+ P
Sbjct: 11734 DCGTDKTKANVTVEARLIKVEKP-----LYGVEVFVGETA------HFEIEL-SEPDVHG 11781
Query: 2272 MWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL 2331
W + LTA I K L + N +L + + A N +S ++++ L
Sbjct: 11782 QWKLKGQP-LTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAAN--AKSAANLKVKEL 11838
Query: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL-I 2390
++ F P ++ V + ++ C V P W+ GT+ G ++ +
Sbjct: 11839 PLI----FITPLSDVKVFEKDEA-KFECEV-SREPKTFRWL--KGTQEITGDDRFELIKD 11890
Query: 2391 ASNGSFIISKTTREDAGKYRCAARNK 2416
+ S +I ED KY A +K
Sbjct: 11891 GTKHSMVIKSAAFEDEAKYMFEAEDK 11916
Score = 33.1 bits (74), Expect = 3.7
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 4/69 (5%)
Query: 2555 VPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
VP P ++W + AS T ++ H+ L + +D+GIY T +N LGS
Sbjct: 14413 VPVPTVSWHKDGKEV--KASDRLTMKND--HISAHLEVPKSVRADAGIYTITLENKLGSA 14468
Query: 2615 YAATYIQVI 2623
A+ ++VI
Sbjct: 14469 TASINVKVI 14477
Score = 33.1 bits (74), Expect = 3.7
Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 8/92 (8%)
Query: 2538 IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHG------SEQLHLQGTLV 2591
+V + G+ ++ V G P P+ +WE + A K+ H E ++
Sbjct: 15820 LVCKAGSQIRIPAVIKGRPTPKSSWEFDGKA--KKAMKDGVHDIPEDAQLETAENSSVII 15877
Query: 2592 IQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
I + S +G Y TAKN G A ++V+
Sbjct: 15878 IPECKRSHTGKYSITAKNKAGQKTANCRVKVM 15909
Score = 33.1 bits (74), Expect = 3.7
Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 1744 PPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILA------NQTVVSESSQGSRQA 1797
PP I + E V G+ V + + +G P PT+TW A N+ V + ++
Sbjct: 16117 PPSIDLKEFME--VEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNK-L 16173
Query: 1798 VVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
VV TLV+ D G Y A N G S +++ V+ P
Sbjct: 16174 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217
Score = 33.1 bits (74), Expect = 3.7
Identities = 24/106 (22%), Positives = 45/106 (42%), Gaps = 5/106 (4%)
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA 2406
++ + G S + G P P ++W P+ + ++Y S S I R D+
Sbjct: 26196 LIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRT---RAYVDTTDSRTSLTIENANRNDS 26252
Query: 2407 GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSL 2452
GKY +N + +++++ P T TV+ ++ ES L
Sbjct: 26253 GKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI--TVQDVTKESAVL 26296
Score = 33.1 bits (74), Expect = 3.7
Identities = 102/563 (18%), Positives = 201/563 (35%), Gaps = 84/563 (14%)
Query: 2110 GVAEEGDY--TCYAQNTLG-KDEMKVHLTVITAA----PRIRQSNKTNKRI--KAGDTAV 2160
G+ E +Y +A+N G D ++ L V+ P I N + + +AG
Sbjct: 26436 GLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLK 26495
Query: 2161 LDCEVTGDPKPKIFWL---LPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARN 2217
+D ++G P PK+ +P + F+ + N ++ + + D+G Y A N
Sbjct: 26496 VDIPISGKPLPKVTLSRDGVPLKATMRFNTEITA--ENLTINLKESVTADAGRYEITAAN 26553
Query: 2218 PSGDDTKMYKLDVVSKP-PLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMP 2276
SG + V+ +P P + + ++ ++ +D ++ T +I+
Sbjct: 26554 SSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTN-----YILL 26608
Query: 2277 DNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEML-- 2334
TA + TV + +++ + + F A N G S + V L
Sbjct: 26609 KRETSTAVWTEVSATVART-MMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPY 26667
Query: 2335 ------RRPTFRNPFNEKIVA------QLGKSTALNCSVDGNPPPEIIWILPNGTRFSNG 2382
P N E I G S + ++ I+W
Sbjct: 26668 TTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILW----------- 26716
Query: 2383 PQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTV 2442
Q L+ F ++ + ++R A N G + +PV+ A
Sbjct: 26717 -QKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKP----SHPSEPVLAIDACEPP 26771
Query: 2443 KGISGESLSLHCVSDGIPKPNIKWTMPS--------GYVVDRPQI------NGKYILHDN 2488
+ + +S + VS + W P+ GY+V+R + +
Sbjct: 26772 RNVRITDISKNSVS-------LSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTE 26824
Query: 2489 GTLVIKEATAYDRGNYICKAQNSVGH----TLITVPVMIV-AYPPRITNRP---PRSIVT 2540
+I T + + A+N+VG + + P+ + +Y + + P +
Sbjct: 26825 TQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKY 26884
Query: 2541 RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDS 2600
R G + +L G P P I W D L + A + ++ +++I++ +S
Sbjct: 26885 RAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDL----ASILIKDADRLNS 26940
Query: 2601 GIYKCTAKNPLGSDYAATYIQVI 2623
G Y+ +N +GS A +Q++
Sbjct: 26941 GCYELKLRNAMGSASATIRVQIL 26963
Score = 32.7 bits (73), Expect = 4.8
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 2352 GKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFI--ISKTTREDAGKY 2409
G++ C V G P P++ W L NG +S ++ + +G I D G+
Sbjct: 1855 GETARFRCRVTGYPQPKVNWYL-NGQLIR---KSKRFRVRYDGIHYLDIVDCKSYDTGEV 1910
Query: 2410 RCAARNKVGYIEKLVILEIGQK 2431
+ A N G IE V LEI Q+
Sbjct: 1911 KVTAENPEGVIEHKVKLEIQQR 1932
Score = 32.7 bits (73), Expect = 4.8
Identities = 24/87 (27%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 2441 TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD 2500
TVK +G + L G P+P I WT + +I + + T+ I ++ D
Sbjct: 13701 TVK--AGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENV-PKKSTVTIVDSKRSD 13757
Query: 2501 RGNYICKAQNSVGHTLITVPVMIVAYP 2527
G YI +A N G V V ++ P
Sbjct: 13758 TGTYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 32.7 bits (73), Expect = 4.8
Identities = 27/108 (25%), Positives = 43/108 (39%), Gaps = 3/108 (2%)
Query: 1823 SNPGGQDSLLVKIQVIAAPPVILEQR-RQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
S P + I AP L+ + + VIV GE+ L +G P P V W DG
Sbjct: 24687 SEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVW-SKDG 24745
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRV 1929
E++ TL +++ +D G Y + S+ G + +
Sbjct: 24746 KELEETAARMEIKSTIQKTTLVVKDCIRTDGGQY-ILKLSNVGGTKSI 24792
Score = 32.7 bits (73), Expect = 4.8
Identities = 22/92 (23%), Positives = 38/92 (41%), Gaps = 12/92 (13%)
Query: 1755 ITVHSGSTVELKCRAEGRPSPTVTWILANQTV-----VSESSQGSRQAVVTVDGTLVLHN 1809
+T+ +GS + L G+P P + W ++ + VS G R T V+
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKR-------ATAVIKF 29109
Query: 1810 LSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
D G Y N G ++ V ++V+ +P
Sbjct: 29110 CDRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141
Score = 32.7 bits (73), Expect = 4.8
Identities = 41/174 (23%), Positives = 58/174 (33%), Gaps = 28/174 (16%)
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
G P P KWT + R I + LVIKEA D G Y +N G +
Sbjct: 30162 GKPFPICKWTKEGQDISKRAMIATS---ETHTELVIKEADRGDSGTYDLVLENKCGKKAV 30218
Query: 2518 TVPVMIVAYP----------------PRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT 2561
+ V ++ P R++ RPP G A L + P+
Sbjct: 30219 YIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPAD----DGGADILGYILERREVPKAA 30274
Query: 2562 WEMPDH-----SLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNP 2610
W D SL+ KE ++ + I P S+ + T NP
Sbjct: 30275 WYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNP 30328
Score = 32.3 bits (72), Expect = 6.3
Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 2543 GAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGI 2602
G ++ V G P P W + L K+R + + + L+I++ D G
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGEL----DKDRVV-IDNVGTKSELIIKDALRKDHGR 15173
Query: 2603 YKCTAKNPLGSDYAATYIQV 2622
Y TA N GS +AA ++V
Sbjct: 15174 YVITATNSCGSKFAAARVEV 15193
Score = 32.3 bits (72), Expect = 6.3
Identities = 74/376 (19%), Positives = 133/376 (35%), Gaps = 53/376 (14%)
Query: 1674 GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDH 1733
G P PT+ W L + + + + ++ I+ + +G Y A N G
Sbjct: 16550 GKPPPTVTWNMNERTLPQEATIETTAI----SSSMVIKNCQRSHQGVYSLLAKNEAGERK 16605
Query: 1734 LHVTLSVVSYP-----PRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVS 1788
+ + V+ P P + T E + + E + SP +++
Sbjct: 16606 KTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPE-----DDGGSPITNYVI------- 16653
Query: 1789 ESSQGSRQAVVTVDGTLVLHNLSIYD-----RGFYKCVASNPGGQDSLLVKIQ--VIAAP 1841
E + R+A V T+ N ++ F++ A N G + + VI P
Sbjct: 16654 EKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREP 16713
Query: 1842 PVILEQRRQVIVGTWGESLKLPCTAKGTP------QPSVYWVLSD---GTEVKPLQFTNS 1892
+ E+ + V E K T P + +VL GTE K + TN
Sbjct: 16714 ITVPERPEDLEVK---EVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTE-KFHKVTND 16769
Query: 1893 KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVM---LTMEERVTSPRIEAASQK 1949
L + ++ L D Y A + G + +T ++ + P + +
Sbjct: 16770 NLL---SRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRD 16826
Query: 1950 RTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEK 2009
+ + G+ L +G+PKP++ W V++ + I P +L + + K
Sbjct: 16827 KLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDR---THIKTTP-ATLALEKIKAK 16882
Query: 2010 --DSGVYLCVARNKMG 2023
DSG Y V N G
Sbjct: 16883 RSDSGKYCVVVENSTG 16898
Score = 32.3 bits (72), Expect = 6.3
Identities = 20/88 (22%), Positives = 36/88 (40%), Gaps = 2/88 (2%)
Query: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQ 1716
+ + A + + G P+PTI W + L + R + + LS++
Sbjct: 22552 TIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATS--LSVKDAVRV 22609
Query: 1717 DRGQYLCSASNLFGTDHLHVTLSVVSYP 1744
D G Y+ A N+ G + V + V+ P
Sbjct: 22610 DSGNYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 32.3 bits (72), Expect = 6.3
Identities = 21/82 (25%), Positives = 35/82 (42%), Gaps = 4/82 (4%)
Query: 2537 SIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQ 2596
S++ + G Q+ G P P +TW + +L S A + E L I
Sbjct: 27280 SVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA----RYSIENTDSSSLLTIPQVT 27335
Query: 2597 TSDSGIYKCTAKNPLGSDYAAT 2618
+D+G Y T +N +G ++T
Sbjct: 27336 RNDTGKYILTIENGVGEPKSST 27357
Score = 32.0 bits (71), Expect = 8.3
Identities = 33/149 (22%), Positives = 67/149 (44%), Gaps = 8/149 (5%)
Query: 409 PKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPV 468
P P+ F + +++ ++ ++ + + T ++ + +A++T PV
Sbjct: 877 PLPQFPFADTPDTYKSEAGVEVKKEVGVSITGTTVREERFEVLHGREAKVTETARVPAPV 936
Query: 469 KHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRI 528
+ T + + K TV+ G +V L C G P+P V W D ++ + S D +I
Sbjct: 937 EIPVTPPTLVSGLK-NVTVIEGESVTLECHISGYPSPTVTWYRED-YQIES---SIDFQI 991
Query: 529 LIDKSGKLELQMADSF--DTGVYHCISSN 555
+SG L + ++F D+G + C + N
Sbjct: 992 TF-QSGIARLMIREAFAEDSGRFTCSAVN 1019
Score = 32.0 bits (71), Expect = 8.3
Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 10/105 (9%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLF--- 1897
PP IL + I G+ L++ G P P+ W + V T+S L +
Sbjct: 18899 PPKILMPEQITIKA--GKKLRIEAHVYGKPHPTCKWKKGEDEVV-----TSSHLAVHKAD 18951
Query: 1898 SNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
S+ L I+++ D G Y A +S+G++ + + + + + P+
Sbjct: 18952 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQ 18996
Score = 32.0 bits (71), Expect = 8.3
Identities = 58/251 (23%), Positives = 104/251 (41%), Gaps = 39/251 (15%)
Query: 2218 PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH--FDCRAEGTPSPEVMWIM 2275
PS + +D KP +IN + N + T ++ H E P W+
Sbjct: 20264 PSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMK 20322
Query: 2276 PDNIFLTAPYYGSRIT-VHKNGTLEIRNVRLSDSADFICVARNEGGESVLVV-QLEVLEM 2333
+++ P +T + + G E R +R ++A I A +E E+++ + E +
Sbjct: 20323 ANHV--NVPECAFTVTDLVEGGKYEFR-IRAKNTAGAIS-APSESTETIICKDEYEAPTI 20378
Query: 2334 LRRPTFRNPFNEKIVAQLGKSTALNC-SVDGNPPPEIIW------ILPNG-TRFSNGPQS 2385
+ PT + + + + G + LN S+ G P P+ W I P+ T+ ++ P S
Sbjct: 20379 VLDPTIK----DGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 20434
Query: 2386 YQYLIASNGSFIISKTTREDAGKYRCAARN----KVGYIEKLVILEIGQKPVILTYAPGT 2441
I TR+DAG+Y A N KV ++ K+ +L++ P P
Sbjct: 20435 --------SMLTIKYATRKDAGEYTITATNPFGTKVEHV-KVTVLDVPGPP-----GPVE 20480
Query: 2442 VKGISGESLSL 2452
+ +S E +L
Sbjct: 20481 ISNVSAEKATL 20491
Score = 32.0 bits (71), Expect = 8.3
Identities = 45/171 (26%), Positives = 67/171 (39%), Gaps = 25/171 (14%)
Query: 2373 LPNG----TRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYI-------E 2421
LPNG FSN I N F +S T + A ++R A+N G I +
Sbjct: 21398 LPNGRWLKANFSN--------ILEN-EFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSD 21448
Query: 2422 KLVILEIGQKPVILTYAP--GTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQI 2479
+ + + P I TV +GE+ L G P P ++W+ + ++
Sbjct: 21449 AITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKL 21508
Query: 2480 NGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHT--LITVPVMIVAYPP 2528
K I + LV K++T D G Y A N G + V V+ PP
Sbjct: 21509 EIK-IADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPP 21558
Score = 32.0 bits (71), Expect = 8.3
Identities = 25/100 (25%), Positives = 43/100 (43%), Gaps = 4/100 (4%)
Query: 1744 PPRILERRTKEITVH--SGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTV 1801
PP I + TV+ +GS +++ G+P P VT L+ V +++ +
Sbjct: 26473 PPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVT--LSRDGVPLKATMRFNTEITAE 26530
Query: 1802 DGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP 1841
+ T+ L D G Y+ A+N G + I V+ P
Sbjct: 26531 NLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRP 26570
Score = 32.0 bits (71), Expect = 8.3
Identities = 30/129 (23%), Positives = 49/129 (37%), Gaps = 7/129 (5%)
Query: 2310 DFICVARNEGGE----SVLVVQLEVLEMLRRPTFRNP--FNEKIVAQLGKSTALNCSVDG 2363
+F ARN G S +V + ++ P P + E + + G S L + G
Sbjct: 26839 EFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISG 26898
Query: 2364 NPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKL 2423
P P I W + +N + S +I R ++G Y RN +G
Sbjct: 26899 KPAPTIEWYKDDKELQTNALVCVEN-TTDLASILIKDADRLNSGCYELKLRNAMGSASAT 26957
Query: 2424 VILEIGQKP 2432
+ ++I KP
Sbjct: 26958 IRVQILDKP 26966
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 207 bits (527), Expect = 1e-52
Identities = 245/927 (26%), Positives = 383/927 (41%), Gaps = 118/927 (12%)
Query: 1659 TIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVE---- 1714
T ++ +PC A G+P + W + +G D+ V NGTL +
Sbjct: 96 TFSSSVGVVVPCPAAGSPSAALRWY-LATGDDIYDVPHIRHVHA--NGTLQLYPFSPSAF 152
Query: 1715 ---IQDRGQYLCSASNLFGTDHL-HVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAE 1770
I D Y C+A N G ++ + V P + R ++ G+ KC
Sbjct: 153 NSFIHDN-DYFCTAENAAGKIRSPNIRVKAVFREPYTV--RVEDQRSMRGNVAVFKCLIP 209
Query: 1771 GRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR-GFYKCVASNPGGQD 1829
V+ + + VS + + +T G L + ++ D Y+C+ + +
Sbjct: 210 SSVQEYVSVVSWEKDTVSIIPE--HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGE 267
Query: 1830 S-------LLVKIQVIAAPPVILEQRRQVIVGTW-GESLKLPCTAKGTPQPSVYWVLSDG 1881
+ L V + P ++ Q + W G +++LPCTA G P P++ W L DG
Sbjct: 268 TRQSNGARLSVTDPAESIPTILDGFHSQEV---WAGHTVELPCTASGYPIPAIRW-LKDG 323
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
+PL +S+ G L I +L + D GTY C T++ GS +L V P
Sbjct: 324 ---RPLP-ADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILM----VIDP 374
Query: 1942 RIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSL 2001
+ K+ + G ++L+C+ TG P+ I W ++ V+ + I N +L
Sbjct: 375 LHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE---AISIRGLSNETL 431
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
I S + SG Y C A K ++L +I + K V G+ F + C
Sbjct: 432 LITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV-SSFSEKVVNPGEQFSLMCA 490
Query: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTL-YFNKVG--VAEEGDYT 2118
A G+P P ++W+L D ++ D HRT +YT+ + T+ + N G + + G Y
Sbjct: 491 AKGAPPPTVTWALDDEPIVR------DGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYR 544
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFW--- 2175
C A+N +G E + + V P IR N AG +++C V G P I W
Sbjct: 545 CTARNLVGSAEYQARINV-RGPPSIRAMR--NITAVAGRDTLINCRVIGYPYYSIKWYKD 601
Query: 2176 --LLPSNDMISFSIDRYTFHANGSLTINKV-KLLDSGEYVC-VARNPSGDDTKMYKLDVV 2231
LLP N R NG+L + V K +D GEY+C V P ++ + V
Sbjct: 602 ALLLPDNH-------RQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV-AV 653
Query: 2232 SKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSP-EVMWIMPDNIFLTAPYYGSRI 2290
PPLI I + C P + W + ++ GS +
Sbjct: 654 KVPPLIQPFEFPPASIGQLL------YIPCVVSSGDMPIRITWRKDGQVIIS----GSGV 703
Query: 2291 TVHKN---GTLEIRNVRLSDSADFICVARNEGG----ESVLVVQLEVLEMLRRPTFRNPF 2343
T+ +L+I +V L + ++ C+A N E L+V++ +++ P
Sbjct: 704 TIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQ------PN 757
Query: 2344 NEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY-------QYLIASNGSF 2396
N+ + GK+ LNCSVDG PPP+++W G S PQ Y + I N S
Sbjct: 758 NQDGI--YGKAGVLNCSVDGYPPPKVMWKHAKG---SGNPQQYHPVPLTGRIQILPNSSL 812
Query: 2397 IISKTTREDAGKYRCAARNKVGY-IEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCV 2455
+I ED G Y C A N VG I K + L + + P ++T P T I G + L+C
Sbjct: 813 LIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV-KIPAMITSHPNTTIAIKGHAKELNCT 871
Query: 2456 SDGIPKPNIKWTMPSGYVVDRPQINGKYIL--HDNG-----TLVIKEATAYDRGNYICKA 2508
+ G I+W G V P +Y + DNG TL +K A D + C A
Sbjct: 872 ARGERPIIIRW--EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 929
Query: 2509 QNSVGHT--LITVPVMIVAYPPRITNR 2533
NS G LI + V PP + R
Sbjct: 930 INSYGEDRGLIQLTVQEPPDPPELEIR 956
Score = 173 bits (438), Expect = 2e-42
Identities = 218/911 (23%), Positives = 353/911 (38%), Gaps = 116/911 (12%)
Query: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLS- 1811
+++T S V + C A G PS + W LA + + V +GTL L+ S
Sbjct: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRH---VHANGTLQLYPFSP 149
Query: 1812 ------IYDRGFYKCVASNPGGQ-DSLLVKIQVIAAPP--VILEQRRQVIVGTWGESLKL 1862
I+D ++ C A N G+ S ++++ + P V +E +R + G
Sbjct: 150 SAFNSFIHDNDYF-CTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR----GNVAVF 204
Query: 1863 PCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDR-GTYECIATS 1921
C + Q V V + V + + F+ +G LYI ++ D TY CI
Sbjct: 205 KCLIPSSVQEYVSVVSWEKDTVSIIP--EHRFFITYHGGLYISDVQKEDALSTYRCITKH 262
Query: 1922 STGSERRV---VMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP 1978
E R L++ + S EV G + L C+A+G P P I W
Sbjct: 263 KYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKD 322
Query: 1979 SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDD------LILMHVS 2032
+ + W L I + +DSG Y+C N G +++ +
Sbjct: 323 GRPLPADSR----WTKRITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH 376
Query: 2033 LRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHR 2092
+ L P K+ + G + C +GSP I W N + D
Sbjct: 377 VTLTPKKL--------KTGIGSTVILSCALTGSPEFTIRWYR------NTELVLPDEAIS 422
Query: 2093 TRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKR 2152
R +N TL + G Y C+A + + + PRI S+ + K
Sbjct: 423 IRG---LSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRI-VSSFSEKV 478
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMI---SFSIDRYTFHANGSLTINKV---KLL 2206
+ G+ L C G P P + W L ++ S ++YT +++ V ++
Sbjct: 479 VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR 538
Query: 2207 DSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGT 2266
D G Y C ARN G +++V P + R + TAV +CR G
Sbjct: 539 DGGVYRCTARNLVGSAEYQARINVRGPPSI-------RAMRNITAVAGRDTLINCRVIGY 591
Query: 2267 PSPEVMW-----IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLS-DSADFICVARNEGG 2320
P + W ++PDN R V +NGTL++ +V+ D +++C +
Sbjct: 592 PYYSIKWYKDALLLPDN---------HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ-- 640
Query: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVD-GNPPPEIIWILPNGTRF 2379
L + V ++ P PF E A +G+ + C V G+ P I W
Sbjct: 641 -PQLSISQSVHVAVKVPPLIQPF-EFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVII 698
Query: 2380 SNGP---QSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYI--EKLVILEIGQKPVI 2434
S +S +++ S IS + + G Y C A N + E+ +I+ + + V+
Sbjct: 699 SGSGVTIESKEFM----SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV 754
Query: 2435 LTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQ------INGKYILHDN 2488
P GI G++ L+C DG P P + W G PQ + G+ + N
Sbjct: 755 ---QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGS--GNPQQYHPVPLTGRIQILPN 809
Query: 2489 GTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQL 2548
+L+I+ D G Y+C+A N VG + + V P IT+ P +I + G A +L
Sbjct: 810 SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK-GHAKEL 868
Query: 2549 HCVALGVPKPEITWEMPD-----HSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
+C A G I WE D ++ A + +G E + TL ++ DS +
Sbjct: 869 NCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDE---VVSTLKLKPADRGDSVFF 925
Query: 2604 KCTAKNPLGSD 2614
C A N G D
Sbjct: 926 SCHAINSYGED 936
Score = 134 bits (336), Expect = 2e-30
Identities = 222/966 (22%), Positives = 363/966 (37%), Gaps = 158/966 (16%)
Query: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEI- 1715
+ T A D + C +G P +I W + D N R V NGTL + V+
Sbjct: 573 NITAVAGRDTLINCRVIGYPYYSIKWYK-----DALLLPDNHRQVVFENGTLKLTDVQKG 627
Query: 1716 QDRGQYLCSA---SNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGR 1772
D G+YLCS L + +HV + V PP I ++ G + + C
Sbjct: 628 MDEGEYLCSVLIQPQLSISQSVHVAVKV---PPLIQPFEFPPASI--GQLLYIPCVVSSG 682
Query: 1773 PSPT-VTWILANQTVVSESSQGSRQAVVTVDG-----TLVLHNLSIYDRGFYKCVASNPG 1826
P +TW Q ++S S VT++ +L + ++S+ G Y C+ASN
Sbjct: 683 DMPIRITWRKDGQVIISGSG-------VTIESKEFMSSLQISSVSLKHNGNYTCIASNAA 735
Query: 1827 GQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGT---- 1882
S ++ V P +++ Q G +G++ L C+ G P P V W + G+
Sbjct: 736 ATVSRERQLIVRVPPRFVVQPNNQD--GIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 793
Query: 1883 EVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
+ P+ T ++ + N +L IR++ D G Y C A++ G++ + +M V P
Sbjct: 794 QYHPVPLTG-RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTD---ISKSMFLTVKIPA 849
Query: 1943 IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF 2002
+ + T G LNC+A GE I W V+D + I NG
Sbjct: 850 MITSHPNTTIAIKGHAKELNCTARGERPIIIRWE-KGDTVIDPDRVMRYAIATKDNGDEV 908
Query: 2003 IGSVTEK-----DSGVYLCVARNKMGDD--LILMHVSLRLKPAKIDHKQ----------- 2044
+ ++ K DS + C A N G+D LI + V P +++ ++
Sbjct: 909 VSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWT 968
Query: 2045 --YFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTM-----INNAMQAD---DSGHRTR 2094
+ ++ G D + K+ SW T IN A D S + R
Sbjct: 969 QRFDGNSIITGFDIEYKNKSD-------SWDFKQSTRNISPTINQANIVDLHPASVYSIR 1021
Query: 2095 RYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKD--EMKVHLTVITA--------APRIR 2144
Y+ FNK+G +E + D M V L +T+ AP+
Sbjct: 1022 MYS--------FNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKE 1073
Query: 2145 QSN----------KTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA 2194
N + N G ++++ + TGD + ++ L + + F+
Sbjct: 1074 LQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSE--VYTLDNLKKFAQYGVVVQAFNR 1131
Query: 2195 NG----SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT 2250
G S IN L D PS + L + S +I+ R+ +
Sbjct: 1132 AGTGPSSSEINATTLEDV---------PSQPPENVRALSITSDVAVISWSEPPRSTLNGV 1182
Query: 2251 AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSAD 2310
+ + +G W NI T +E+R + +
Sbjct: 1183 LKGYRVIFWSLYVDGE------WGEMQNITTTRE------------RVELRGMEKFTNYS 1224
Query: 2311 FICVARNEGGESVL--VVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPE 2368
+A + G+ V V+ ++ E + P P K V S+A + V PP +
Sbjct: 1225 VQVLAYTQAGDGVRSSVLYIQTKEDVPGP----PAGIKAVP----SSASSVVVSWLPPTK 1276
Query: 2369 IIWILPNGTRFSNGPQSYQ-----YLIASNGSFI-ISKTTREDAGKYRCAARNKVGY--- 2419
++ T F + P S Q Y + F I+ R AA G
Sbjct: 1277 PNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNS 1336
Query: 2420 IEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQI 2479
EK+ I G+ P + GTV + + L C S G P P +KWT S +
Sbjct: 1337 SEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSM 1396
Query: 2480 NGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIV 2539
+G ++H NGTL+++ A D G Y C A N+ G I V +++ P + PR V
Sbjct: 1397 DGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ-----PRLTV 1451
Query: 2540 TRTGAA 2545
++T A+
Sbjct: 1452 SKTSAS 1457
Score = 60.1 bits (144), Expect = 3e-08
Identities = 34/133 (25%), Positives = 59/133 (44%), Gaps = 1/133 (0%)
Query: 1821 VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
V S G S V I+ P + + W + ++LPC + G P P+V W
Sbjct: 1328 VTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS 1387
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
P+ +L + +NGTL +R + + D G Y C AT++ G + +V L ++
Sbjct: 1388 EDSAIPVSMDGHRL-IHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ 1446
Query: 1941 PRIEAASQKRTEV 1953
PR+ + + +
Sbjct: 1447 PRLTVSKTSASSI 1459
Score = 57.0 bits (136), Expect = 2e-07
Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 3/101 (2%)
Query: 1659 TIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDR 1718
T P D LPC +VG+P P + WT+ + R+ + NGTL ++ V+ +D
Sbjct: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRL-IHTNGTLLLRAVKAEDS 1418
Query: 1719 GQYLCSASNLFGTDHLHVTLSVVSYP--PRILERRTKEITV 1757
G Y C+A+N G D + V L V P PR+ +T ++
Sbjct: 1419 GYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSI 1459
Score = 53.9 bits (128), Expect = 2e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 7/101 (6%)
Query: 1763 VELKCRAEGRPSPTVTWILANQ-TVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
V L C + G P+P V W ++ + + S G R ++ +GTL+L + D G+Y C
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHR--LIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKL 1862
A+N GG D+++V + ++ PP +Q R + T S+ L
Sbjct: 1425 ATNTGGFDTIIVNL-LVQVPP---DQPRLTVSKTSASSITL 1461
Score = 52.0 bits (123), Expect = 8e-06
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 2/91 (2%)
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRD--KKVLNNGTLRILQVTPKDQGYYRCVAANP 650
LPC+S G P ++ W + S D + + NGTL + V +D GYY C A N
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
Query: 651 SGVDFLIFQVSVKMKGQRPLEHDGETEGSGL 681
G D +I + V++ +P +T S +
Sbjct: 1429 GGFDTIIVNLLVQVPPDQPRLTVSKTSASSI 1459
Score = 50.8 bits (120), Expect = 2e-05
Identities = 48/161 (29%), Positives = 67/161 (41%), Gaps = 9/161 (5%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G TV L C G P P + WL DG + A D R +G L + + D+
Sbjct: 297 VWAGHTVELPCTASGYPIPAIRWL-KDGRPLPA-----DSRWTKRITG-LTISDLRTEDS 349
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C +N + T + V++PL + IG T+ L C TG P+ +I
Sbjct: 350 GTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLK--TGIGSTVILSCALTGSPEFTIR 407
Query: 607 WVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVA 647
W VL + + L+N TL I G Y+C A
Sbjct: 408 WYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
Score = 47.0 bits (110), Expect = 2e-04
Identities = 46/169 (27%), Positives = 62/169 (36%), Gaps = 16/169 (9%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDW------LLADGSKVRAPYVSEDGRILIDKSGKLE 537
E V G L C +G P P V W ++ DGS Y DG + +
Sbjct: 476 EKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI----SHMN 531
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHS 597
+ D GVY C + N + RI V P N T G + C
Sbjct: 532 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN---ITAVAGRDTLINCRV 588
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP-KDQGYYRC 645
G P SI W + +L + + V NGTL++ V D+G Y C
Sbjct: 589 IGYPYYSIKWY--KDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC 635
Score = 47.0 bits (110), Expect = 2e-04
Identities = 64/242 (26%), Positives = 100/242 (41%), Gaps = 22/242 (9%)
Query: 435 SLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVG 494
SLQ++ + + +S+A T+ R V+ + + NN + G
Sbjct: 713 SLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNN----QDGIYGKAGV 768
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPY--VSEDGRILIDKSGKLELQMADSFDTGVYHCI 552
LNC G P P V W A GS Y V GRI I + L ++ D G Y C
Sbjct: 769 LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQ 828
Query: 553 SSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI-GETLDLPCHSTGIPDASISW---- 607
+SN DI V+ + A + + T+ I G +L C + G I W
Sbjct: 829 ASNGVGTDISKSMFLTVK--IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGD 886
Query: 608 -VIPGNNVLYQSSRDKKVLNNG--TLRILQVTPKDQG---YYRCVAANPSGVDFLIFQVS 661
VI + V+ + K +NG + L++ P D+G ++ C A N G D + Q++
Sbjct: 887 TVIDPDRVMRYAIATK---DNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLT 943
Query: 662 VK 663
V+
Sbjct: 944 VQ 945
Score = 44.3 bits (103), Expect = 0.002
Identities = 42/185 (22%), Positives = 72/185 (38%), Gaps = 22/185 (11%)
Query: 2433 VILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGT-- 2490
V++++ P T ++ C S G +P PS Y Q+ + + G
Sbjct: 1267 VVVSWLPPTKPNGVIRKYTIFCSSPGSGQP-----APSEYETSPEQLFYRIAHLNRGQQY 1321
Query: 2491 -LVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLH 2549
L + T+ RGN ++ P I+++ +T + + +L
Sbjct: 1322 LLWVAAVTSAGRGN---SSEKVTIEPAGKAPAKIISFGGTVTTPWMKDV--------RLP 1370
Query: 2550 CVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
C ++G P P + W S + G +H GTL+++ + DSG Y CTA N
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMD---GHRLIHTNGTLLLRAVKAEDSGYYTCTATN 1427
Query: 2610 PLGSD 2614
G D
Sbjct: 1428 TGGFD 1432
Score = 43.1 bits (100), Expect = 0.004
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 2/79 (2%)
Query: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCI 552
V L C GDP P V W S+ A VS DG LI +G L L+ + D+G Y C
Sbjct: 1367 VRLPCNSVGDPAPAVKW--TKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 553 SSNYDDADILTYRITVVEP 571
++N D + + V P
Sbjct: 1425 ATNTGGFDTIIVNLLVQVP 1443
Score = 40.4 bits (93), Expect = 0.023
Identities = 40/150 (26%), Positives = 62/150 (41%), Gaps = 24/150 (16%)
Query: 524 EDGRILIDKSG----------KLELQMADSFDTGVYHCISSNYDDADILTYRITVVEP-- 571
+DG+++I SG L++ G Y CI+SN ++ V P
Sbjct: 692 KDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR 751
Query: 572 -LVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIP---GNNVLYQS---SRDKKV 624
+V+ ++GI+ G+ L C G P + W GN Y + ++
Sbjct: 752 FVVQPNNQDGIY-----GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQI 806
Query: 625 LNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
L N +L I V +D GYY C A+N G D
Sbjct: 807 LPNSSLLIRHVLEEDIGYYLCQASNGVGTD 836
Score = 38.5 bits (88), Expect = 0.088
Identities = 28/108 (25%), Positives = 42/108 (38%), Gaps = 14/108 (12%)
Query: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
K L C+ G+P P + W + LI +NG+ ++ ED+G Y C
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 2413 ARNKVGYIEKLVILEIGQKP--------------VILTYAPGTVKGIS 2446
A N G+ +V L + P + LT+ PG G S
Sbjct: 1425 ATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSS 1472
Score = 38.1 bits (87), Expect = 0.12
Identities = 37/170 (21%), Positives = 69/170 (40%), Gaps = 11/170 (6%)
Query: 489 VGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGV 548
+G TV L+C G P + W +++ P + R L +++ L + A +G
Sbjct: 388 IGSTVILSCALTGSPEFTIRWYR--NTELVLPDEAISIRGLSNET--LLITSAQKSHSGA 443
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
Y C ++ + I +E + V GE L C + G P +++W
Sbjct: 444 YQCFATRKAQT-AQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
Query: 609 IPGNNVLYQSSR--DKKVLNNGT----LRILQVTPKDQGYYRCVAANPSG 652
+ ++ S ++ +++GT + + +D G YRC A N G
Sbjct: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVG 552
Score = 35.8 bits (81), Expect = 0.57
Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 8/67 (11%)
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPK-------DQGYYRC 645
+PC + G P A++ W + + +Y + V NGTL++ +P D Y+ C
Sbjct: 105 VPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF-C 163
Query: 646 VAANPSG 652
A N +G
Sbjct: 164 TAENAAG 170
Score = 35.0 bits (79), Expect = 0.97
Identities = 28/83 (33%), Positives = 35/83 (42%), Gaps = 12/83 (14%)
Query: 2543 GAAFQLHCVALGVPKPEITWEMPDHSLLSTASK--ERTHGSEQLHLQGTLVIQNPQTSDS 2600
G +L C A G P P I W + D L S+ +R G L I + +T DS
Sbjct: 300 GHTVELPCTASGYPIPAIRW-LKDGRPLPADSRWTKRITG---------LTISDLRTEDS 349
Query: 2601 GIYKCTAKNPLGSDYAATYIQVI 2623
G Y C N GS A + VI
Sbjct: 350 GTYICEVTNTFGSAEATGILMVI 372
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 198 bits (504), Expect = 5e-50
Identities = 247/1008 (24%), Positives = 378/1008 (37%), Gaps = 148/1008 (14%)
Query: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727
L C G + W + L + + SR L + V D G+Y+C
Sbjct: 2746 LNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR--------LRLHHVSPADSGEYVCRVMG 2797
Query: 1728 LFGTDHLHVTLSVVSY-------------PPRILERRTKEITVHSGSTVELKCRAEGRPS 1774
G V +++ + PP +E + + G T++LKC G+
Sbjct: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVA--EGQTLDLKCVVPGQAH 2855
Query: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLV-LHNLSIYDRGFYKCVASNPGG--QDSL 1831
VTW G+ A V G L+ L+ +S D G Y C + G + S+
Sbjct: 2856 AQVTW---------HKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASV 2906
Query: 1832 LVKIQV-----IAAP----PVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGT 1882
LV I+ I AP P+ +E + T G++L L C G V W G+
Sbjct: 2907 LVTIEPSSPGPIPAPGLAQPIYIEASSSHV--TEGQTLDLNCVVPGQAHAQVTWYKRGGS 2964
Query: 1883 EVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRV---VMLTMEE--- 1936
Q S+L L ++ +D G Y C A S G E+ V + E
Sbjct: 2965 LPARHQTHGSQLRLHL--------VSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSS 3016
Query: 1937 -RVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKP-QIMWRLPSKAVVDQQHRVGSWIH 1994
R+ SP I T V G C P + W+ ++ + D +H
Sbjct: 3017 YRLRSPVISIDPPSST-VQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN-------VH 3068
Query: 1995 VYPNGSLF-IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHG 2053
+ PNGS+ I + G Y CVA N G ++++S+ P + V G
Sbjct: 3069 ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH-GPPTVSVLPEGPVWVKVG 3127
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNN-GTLYFNKVGVA 2112
K ++C ++G P W+ T + R Y L ++ L + +
Sbjct: 3128 KAVTLECVSAGEPRSSARWTRISST---------PAKLEQRTYGLMDSHAVLQISSAKPS 3178
Query: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAA-----PRIRQSNKTNKRIKAGDTAVLDCEVTG 2167
+ G Y C AQN LG + +V + V T A P++ Q+ + ++AG TA L C TG
Sbjct: 3179 DAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTVEAGHTATLRCSATG 3237
Query: 2168 DPKPKIFWLLPSNDMISFSIDRYTFHANG-SLTINKVKLLDSGEYVCVARNPSGDDTKMY 2226
P P I W + + + G +L I +V DSG+Y+C A +P+G
Sbjct: 3238 SPAPTIHWSKLRSPL------PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATI 3291
Query: 2227 KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY 2286
L V S P Y A+ C A GTP W + + P
Sbjct: 3292 ILHVESPP------YATTVPEHASVQAGETVQLQCLAHGTPPLTFQW---SRVGSSLP-- 3340
Query: 2287 GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV------LEMLRRPTFR 2340
R T +N L DS + C N+ G + QL V L P
Sbjct: 3341 -GRATA-RNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGS 3398
Query: 2341 NPFNEKIVAQL-----GKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGS 2395
P ++ QL G S +C+V + ++ W F G Q +G
Sbjct: 3399 TP-TVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-------FKEGGQLPPGHSVQDGV 3450
Query: 2396 FIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGIS-GESLSLHC 2454
I + G Y C A G + L I P +L +V+ + G ++ C
Sbjct: 3451 LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC 3510
Query: 2455 VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGH 2514
++ G PKP + W+ G++ RP I + G + I D G Y C A N+ G
Sbjct: 3511 LALGDPKPQVTWSKVGGHL--RPGI-----VQSGGVVRIAHVELADAGQYRCTATNAAGT 3563
Query: 2515 TLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTAS 2574
T V +++ A P P+ + G+A C+A G P P+I+W D SL +
Sbjct: 3564 TQSHVLLLVQALPQISM---PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
Query: 2575 KERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
E L++ + + D+G Y CTA N G A ++QV
Sbjct: 3621 LE----------NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
Score = 182 bits (463), Expect = 3e-45
Identities = 235/1030 (22%), Positives = 393/1030 (38%), Gaps = 157/1030 (15%)
Query: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR-----VPSGLDLSKRKQNSRV 1700
+ P +V A +P L C+ G+P +W+R VPSG +R Q S
Sbjct: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSG--TQQRHQGSE- 1730
Query: 1701 QVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR---ILERRTKEITV 1757
L V+ D G Y+C+ NL ++ L V P + + + +V
Sbjct: 1731 -------LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSV 1783
Query: 1758 HSGSTVELKCRAEGR-PSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
G+ V C A+ + P+ T+ W T + +R + +G L + N+ + D G
Sbjct: 1784 RPGADVTFICTAKSKSPAYTLVW-----TRLHNGKLPTR--AMDFNGILTIRNVQLSDAG 1836
Query: 1817 FYKCVASNPGGQD----SLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQP 1872
Y C SN D +L V+ + PV+ Q+ V G+ + C+A G+P P
Sbjct: 1837 TYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQP-GQLAEFRCSATGSPTP 1895
Query: 1873 SVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVML 1932
++ W G ++ G L + + +D+ Y C A SS G + +L
Sbjct: 1896 TLEWTGGPGGQLPAKA-------QIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVL 1948
Query: 1933 TMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW 1992
+ PR++ S +RT+V+ G + L C A G P I WR ++ Q +
Sbjct: 1949 HVHGG-GGPRVQ-VSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD 2006
Query: 1993 IHVYPNGSLFIGSVTEKDSGVYLCVARNKMG------DDLILMHVSLRLKPAKIDHKQYF 2046
I +L I ++T D+G YLCVA + G ++L P KI+
Sbjct: 2007 I-----ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSS-- 2059
Query: 2047 RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
V G+ ++C +GS +++W G++ +T + L
Sbjct: 2060 -PSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL--------------PPHTQVHGSRLRL 2104
Query: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTV------------ITAAPRIRQSNKTNKRIK 2154
+V A+ G+Y C +N G E + ++V + + R + ++ +
Sbjct: 2105 PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA 2164
Query: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCV 2214
G T L+C V G ++ W + + R+ H + L +++V DSGEYVC
Sbjct: 2165 EGQTLDLNCVVPGQAHAQVTWHKRGGSLPA----RHQTHGS-LLRLHQVTPADSGEYVCH 2219
Query: 2215 ARNPSG--DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVM 2272
SG + + + ++ P I + + +T C G +V
Sbjct: 2220 VVGTSGPLEASVLVTIEASVIPGPIPPVRIESS--SSTVAEGQTLDLSCVVAGQAHAQVT 2277
Query: 2273 WIMPDNIFLTAPYYGSRITVH--KNGTLEIRNVRLSDSADFICVARNEGGESVLV----- 2325
W GS H + L I +D+ ++C A N S+ V
Sbjct: 2278 WYKRG---------GSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGT 2328
Query: 2326 --VQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGP 2383
L +P P + ++ G++ LNC V G ++ W G+ P
Sbjct: 2329 QGANLAYPAGSTQPIRIEPSSSQVAE--GQTLDLNCVVPGQSHAQVTWHKRGGSL----P 2382
Query: 2384 QSYQYLIASNGSFI-ISKTTREDAGKYRCAARNKVGYIEKLVILEI---GQKPVILTYAP 2439
+Q ++GS + + + + D+G+Y C +E V++ I G P +
Sbjct: 2383 VRHQ----THGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPT 2438
Query: 2440 GTVKGIS-----GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIK 2494
++ S G++L L+C+ G + W G + R Q++G L +
Sbjct: 2439 VRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHG-------SRLRLL 2491
Query: 2495 EATAYDRGNYICKAQNSVGHTLITVPVMI-----------VAYPPRITNRPPRSIVTRTG 2543
+ T D G Y+C+ S G +V V I VAYP RI + S G
Sbjct: 2492 QVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES---SSASLANG 2548
Query: 2544 AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
L+C+ ITW SL S+ + GS L I +DSG Y
Sbjct: 2549 HTLDLNCLVASQAPHTITWYKRGGSL---PSRHQIVGSR-------LRIPQVTPADSGEY 2598
Query: 2604 KCTAKNPLGS 2613
C N GS
Sbjct: 2599 VCHVSNGAGS 2608
Score = 173 bits (438), Expect = 2e-42
Identities = 240/983 (24%), Positives = 376/983 (38%), Gaps = 147/983 (14%)
Query: 1708 LSIQRVEIQDRGQYLCSA--SNLFGTDHLHVTLSVVSYPPRILERRTKEIT-----VHSG 1760
L + + D G+Y+C S++ + VT+ P + T I V G
Sbjct: 2392 LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEG 2451
Query: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGT-LVLHNLSIYDRGFYK 1819
T++L C G+ VTW GS A V G+ L L ++ D G Y
Sbjct: 2452 QTLDLNCLVAGQAHAQVTW---------HKRGGSLPARHQVHGSRLRLLQVTPADSGEYV 2502
Query: 1820 C-VASNPGGQD-SLLVKIQVI--------AAPPVILEQRRQVIVGTWGESLKLPCTAKGT 1869
C V + G Q+ S+LV IQ A PV +E + G +L L C
Sbjct: 2503 CRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLAN--GHTLDLNCLVASQ 2560
Query: 1870 PQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRV 1929
++ W G+ Q S+L I + +D G Y C ++ GS
Sbjct: 2561 APHTITWYKRGGSLPSRHQIVGSRL--------RIPQVTPADSGEYVCHVSNGAGSRETS 2612
Query: 1930 VMLTMEERVTS------PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV 1983
+++T++ +S P I S T V G L LNC +P+ I W ++
Sbjct: 2613 LIVTIQGSGSSHVPSVSPPIRIESSSPTVVE-GQTLDLNCVVARQPQAIITWYKRGGSLP 2671
Query: 1984 DQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG--DDLILMHVSLRL------ 2035
+ GS + ++ ++ DSG Y+C A N + + I++ VS
Sbjct: 2672 SRHQTHGSHLRLH--------QMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAP 2723
Query: 2036 ---KPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHR 2092
P +I+ V G+ ++C G +++W G++ S H+
Sbjct: 2724 GSSMPIRIESSS---SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL--------PSHHQ 2772
Query: 2093 TRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA------------A 2140
TR L + V A+ G+Y C + G E V +T+ + A
Sbjct: 2773 TR------GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGA 2826
Query: 2141 PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTI 2200
P IR ++ R+ G T L C V G ++ W ++ + R+ H L +
Sbjct: 2827 PPIR-IEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA----RHQVHGP-LLRL 2880
Query: 2201 NKVKLLDSGEYVCVARNPSG--DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
N+V DSGEY C SG + + + ++ S P+ I+A++ ++
Sbjct: 2881 NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ 2940
Query: 2259 ---FDCRAEGTPSPEVMWIMPDNIFLTAPY--YGSRITVHKNGTLEIRNVRLSDSADFIC 2313
+C G +V W L A + +GS++ +H V +DS +++C
Sbjct: 2941 TLDLNCVVPGQAHAQVTWYKRGGS-LPARHQTHGSQLRLHL--------VSPADSGEYVC 2991
Query: 2314 VARNEGG---ESVLVVQLEVLE----MLRRPTFRNPFNEKIVAQLGKSTALNCSV-DGNP 2365
A + G E+ V + E LR P V Q G+ + C + DG
Sbjct: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQ-GQDASFKCLIHDGAA 3050
Query: 2366 PPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR-EDAGKYRCAARNKVGYIEKLV 2424
P + W N N I+ NGS I TR + G YRC A N G + +V
Sbjct: 3051 PISLEWKTRNQELEDN------VHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVV 3104
Query: 2425 ILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYI 2484
L + P + G V G++++L CVS G P+ + +WT S Q +
Sbjct: 3105 NLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ-RTYGL 3163
Query: 2485 LHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI----VAYPPRITNRPPRSIVT 2540
+ + L I A D G Y+C AQN++G V V++ +A +
Sbjct: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV 3223
Query: 2541 RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQG-TLVIQNPQTSD 2599
G L C A G P P I W SK R+ Q L+G TL+I D
Sbjct: 3224 EAGHTATLRCSATGSPAPTIHW-----------SKLRSPLPWQHRLEGDTLIIPRVAQQD 3272
Query: 2600 SGIYKCTAKNPLGSDYAATYIQV 2622
SG Y C A +P G A + V
Sbjct: 3273 SGQYICNATSPAGHAEATIILHV 3295
Score = 160 bits (406), Expect = 1e-38
Identities = 197/859 (22%), Positives = 318/859 (37%), Gaps = 111/859 (12%)
Query: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVV-SYP----------PRILERRTKEIT 1756
L + +V D G+Y C + GT V +++ S P P +E + +T
Sbjct: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
Query: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
G T++L C G+ VTW ++ + Q L LH +S D G
Sbjct: 2938 --EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ--------LRLHLVSPADSG 2987
Query: 1817 FYKC-VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSV 1874
Y C AS PG + + V + R VI S+ P T + S
Sbjct: 2988 EYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVI------SIDPPSSTVQQGQDASF 3041
Query: 1875 YWVLSDGTEVKPLQFTN------SKLFLFSNGTLY-IRNLASSDRGTYECIATSSTGSER 1927
++ DG L++ + + NG++ I S+ GTY C+A+++ G +
Sbjct: 3042 KCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101
Query: 1928 RVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMW-RLPSKAVVDQQ 1986
VV L++ P + + V G + L C + GEP+ W R+ S +Q
Sbjct: 3102 SVVNLSVHG---PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ 3158
Query: 1987 HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDL----ILMHVSLRLKPAKIDH 2042
G + + L I S D+G Y+C+A+N +G +++ A
Sbjct: 3159 RTYGL---MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
Query: 2043 KQYFRKQVLHGKDFQVDCKASGSPVPEISWS-LPDGTMINNAMQADDSGHRTRRYTLFNN 2101
+ V G + C A+GSP P I WS L + ++ D
Sbjct: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD-------------- 3261
Query: 2102 GTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVL 2161
TL +V + G Y C A + G E + L V +P + + ++AG+T L
Sbjct: 3262 -TLIIPRVAQQDSGQYICNATSPAGHAEATIILHV--ESPPYATTVPEHASVQAGETVQL 3318
Query: 2162 DCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD 2221
C G P W + S+ N L + DSG Y C N G
Sbjct: 3319 QCLAHGTPPLTFQW-----SRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGS 3373
Query: 2222 DTKMYKLDVVSKP---PLINGLYTNRTVIKATAVRHSKK-----HFDCRAEGTPSPEVMW 2273
+L V P P + + ++ T +K F C ++ W
Sbjct: 3374 AEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW 3433
Query: 2274 IMPDNIFLTAPYYGSRITVH--KNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL 2331
G H ++G L I+N+ S +IC A G++ QL V+
Sbjct: 3434 FKEG---------GQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQL-VI 3483
Query: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIA 2391
+ L + + V +G + C G+P P++ W G ++
Sbjct: 3484 QALPSVLINIRTSVQTVV-VGHAVEFECLALGDPKPQVTWSKVGGHLRPG-------IVQ 3535
Query: 2392 SNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLS 2451
S G I+ DAG+YRC A N G + V+L + P I P V+ +G +
Sbjct: 3536 SGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI--SMPQEVRVPAGSAAV 3593
Query: 2452 LHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNS 2511
C++ G P P+I W+ G + ++ +N L++ D G Y+C A N
Sbjct: 3594 FPCIASGYPTPDISWSKLDGSLPPDSRL-------ENNMLMLPSVRPQDAGTYVCTATNR 3646
Query: 2512 VGHTL----ITVPVMIVAY 2526
G + VP +V Y
Sbjct: 3647 QGKVKAFAHLQVPERVVPY 3665
Score = 136 bits (342), Expect = 3e-31
Identities = 134/502 (26%), Positives = 198/502 (39%), Gaps = 73/502 (14%)
Query: 1651 VGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSI 1710
V + A T+ A A L C A G+P PTIHW+++ S L R L TL I
Sbjct: 3214 VQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR--------LEGDTLII 3265
Query: 1711 QRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAE 1770
RV QD GQY+C+A++ G H T+ + P + +V +G TV+L+C A
Sbjct: 3266 PRVAQQDSGQYICNATSPAG--HAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAH 3323
Query: 1771 GRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDS 1830
G P T W ++ ++ + L + D G Y+C +N G
Sbjct: 3324 GTPPLTFQWSRVGSSLPGRATARNE--------LLHFERAAPEDSGRYRCRVTNKVGSAE 3375
Query: 1831 LLVKIQVIAAPPVI------------LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVL 1878
++ V P + ++ Q+ + G S++ C + W
Sbjct: 3376 AFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-F 3434
Query: 1879 SDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
+G ++ P +G L I+NL S +GTY C A G + L + + +
Sbjct: 3435 KEGGQLPPGHSV-------QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI-QAL 3486
Query: 1939 TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIH---V 1995
S I + +T V G + C A G+PKPQ+ W +VG + V
Sbjct: 3487 PSVLINIRTSVQTVV-VGHAVEFECLALGDPKPQVTW-----------SKVGGHLRPGIV 3534
Query: 1996 YPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP-AKIDHKQYFRKQVLHGK 2054
G + I V D+G Y C A N G HV L ++ +I Q R V G
Sbjct: 3535 QSGGVVRIAHVELADAGQYRCTATNAAG--TTQSHVLLLVQALPQISMPQEVR--VPAGS 3590
Query: 2055 DFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
C ASG P P+ISWS DG++ ++ N L V +
Sbjct: 3591 AAVFPCIASGYPTPDISWSKLDGSLPPDSR--------------LENNMLMLPSVRPQDA 3636
Query: 2115 GDYTCYAQNTLGKDEMKVHLTV 2136
G Y C A N GK + HL V
Sbjct: 3637 GTYVCTATNRQGKVKAFAHLQV 3658
Score = 120 bits (301), Expect = 2e-26
Identities = 136/597 (22%), Positives = 217/597 (36%), Gaps = 67/597 (11%)
Query: 2047 RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
R V G + C+ SGSP WS DG + + Q G L+F
Sbjct: 1685 RSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQG-----------SELHF 1733
Query: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAP----RIRQSNKTNKRIKAGDTAVLD 2162
V ++ G Y C +N + + L ++T AP + + ++ ++ G
Sbjct: 1734 PSVQPSDAGVYICTCRNLHQSNTSRAEL-LVTEAPSKPITVTVEEQRSQSVRPGADVTFI 1792
Query: 2163 CEV-TGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD 2221
C + P + W N + NG LTI V+L D+G YVC N
Sbjct: 1793 CTAKSKSPAYTLVWTRLHNG----KLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAM 1848
Query: 2222 DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFL 2281
D L V + L + + + T F C A G+P+P + W L
Sbjct: 1849 DQGTATLHVQASGTLSAPVVSIHPP-QLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQL 1907
Query: 2282 TAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRN 2341
A + +H G L + V +D A ++C A + G+ V L V +
Sbjct: 1908 PA-----KAQIH-GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVS 1961
Query: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKT 2401
P E+ G++ L C G P I W G+ P + + +I
Sbjct: 1962 P--ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL----PPQARSERTDIATLLIPAI 2015
Query: 2402 TREDAGKYRCAARNKVG----YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSD 2457
T DAG Y C A + G I+ +V+ P + + G++L L+CV
Sbjct: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVA 2075
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
G + W G + Q++G L + + + D G Y+C+ +N G
Sbjct: 2076 GSAHAQVTWYRRGGSLPPHTQVHG-------SRLRLPQVSPADSGEYVCRVENGSGPKEA 2128
Query: 2518 TVPVMIV-------AYPP-----RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMP 2565
++ V ++ +Y P R P S G L+CV G ++TW
Sbjct: 2129 SITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKR 2188
Query: 2566 DHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
SL ++ +THGS L + +DSG Y C G A+ + +
Sbjct: 2189 GGSL---PARHQTHGS-------LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
Score = 110 bits (274), Expect = 2e-23
Identities = 120/499 (24%), Positives = 194/499 (38%), Gaps = 53/499 (10%)
Query: 2140 APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLT 2199
AP + + + + G + L C+V+G P +W + + H L
Sbjct: 1675 APLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELH 1732
Query: 2200 INKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKP--PLINGLYTNRTVIKATAVR-HSK 2256
V+ D+G Y+C RN +T +L V P P+ + R + +VR +
Sbjct: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQR----SQSVRPGAD 1788
Query: 2257 KHFDCRAEG-TPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
F C A+ +P+ ++W N L + NG L IRNV+LSD+ ++C
Sbjct: 1789 VTFICTAKSKSPAYTLVWTRLHNGKLPTR------AMDFNGILTIRNVQLSDAGTYVCTG 1842
Query: 2316 RN----EGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIW 2371
N + G + L VQ + P ++ Q G+ CS G+P P + W
Sbjct: 1843 SNMFAMDQGTATLHVQASGTLSAPVVSIHPP---QLTVQPGQLAEFRCSATGSPTPTLEW 1899
Query: 2372 ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEI-GQ 2430
G + Q + G + D +Y C A + G +L + G
Sbjct: 1900 TGGPGGQLPAKAQIH------GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGG 1953
Query: 2431 KPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGT 2490
+ +P + +G ++ L+C + G+P I W G + PQ + D T
Sbjct: 1954 GGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL--PPQARSERT--DIAT 2009
Query: 2491 LVIKEATAYDRGNYICKAQNSVGHTLITVPVMIV----AYPPRITNRPPRSIVTRTGAAF 2546
L+I T D G Y+C A + G + V+++ A PP + VT G
Sbjct: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTE-GQTL 2068
Query: 2547 QLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTS--DSGIYK 2604
L+CV G ++TW SL + HGS ++ PQ S DSG Y
Sbjct: 2069 DLNCVVAGSAHAQVTWYRRGGSL---PPHTQVHGSR---------LRLPQVSPADSGEYV 2116
Query: 2605 CTAKNPLGSDYAATYIQVI 2623
C +N G A+ + V+
Sbjct: 2117 CRVENGSGPKEASITVSVL 2135
Score = 102 bits (253), Expect = 6e-21
Identities = 103/408 (25%), Positives = 162/408 (39%), Gaps = 45/408 (11%)
Query: 2228 LDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYG 2287
L ++ PL+ ++ R+++ HS + C+ G+P W D P
Sbjct: 1669 LPETNQAPLVVEVHPARSIVPQGG-SHSLR---CQVSGSPPHYFYWSREDG----RPVPS 1720
Query: 2288 SRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRP---TFRNPFN 2344
H+ L +V+ SD+ +IC RN + +L V E +P T +
Sbjct: 1721 GTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRS 1780
Query: 2345 EKIVAQLGKSTALNCSVDGNPPP-EIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR 2403
+ + + G C+ P ++W TR NG + + NG I
Sbjct: 1781 QSV--RPGADVTFICTAKSKSPAYTLVW-----TRLHNGKLPTRAM-DFNGILTIRNVQL 1832
Query: 2404 EDAGKYRCAARNKVGYIEKLVILEIGQK-----PVILTYAPG-TVKGISGESLSLHCVSD 2457
DAG Y C N + L + PV+ + P TV+ G+ C +
Sbjct: 1833 SDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQ--PGQLAEFRCSAT 1890
Query: 2458 GIPKPNIKWTM-PSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTL 2516
G P P ++WT P G + + QI+G G L + D+ Y+C+A +S G +
Sbjct: 1891 GSPTPTLEWTGGPGGQLPAKAQIHG-------GILRLPAVEPTDQAQYLCRAHSSAGQQV 1943
Query: 2517 ITVPVMIVAYP-PRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASK 2575
+ + PR+ P R+ V G +L+C A GVP ITW SL A
Sbjct: 1944 ARAVLHVHGGGGPRVQVSPERTQV-HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARS 2002
Query: 2576 ERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
ERT TL+I T+D+G Y C A +P G+ A + V+
Sbjct: 2003 ERTD-------IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVL 2043
Score = 100 bits (248), Expect = 2e-20
Identities = 70/234 (29%), Positives = 107/234 (45%), Gaps = 19/234 (8%)
Query: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
+G L IQ ++ +G Y+C A +G L + + P ++ RT TV G VE
Sbjct: 3448 DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVE 3507
Query: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
+C A G P P VTW S+ R +V G + + ++ + D G Y+C A+N
Sbjct: 3508 FECLALGDPKPQVTW--------SKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATN 3559
Query: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
G V + V A P + + Q +V G+ + PC A G P P + W DG+ +
Sbjct: 3560 AAGTTQSHVLLLVQALPQISMPQEVRVPAGS---AAVFPCIASGYPTPDISWSKLDGS-L 3615
Query: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
P +S+L N L + ++ D GTY C AT+ G + L + ERV
Sbjct: 3616 PP----DSRL---ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERV 3662
Score = 57.8 bits (138), Expect = 1e-07
Identities = 50/202 (24%), Positives = 79/202 (39%), Gaps = 21/202 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV G C G PTP ++W G ++ A G L L + D
Sbjct: 1876 TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH--------GGILRLPAVEPTD 1927
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
Y C + + + + V Q + V G T+ L C + G+P A+I
Sbjct: 1928 QAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI 1987
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV----- 660
+W G ++ Q+ ++ + TL I +T D G+Y CVA +P+G QV
Sbjct: 1988 TWRKEGGSLPPQARSERTDI--ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSA 2045
Query: 661 ------SVKMKGQRPLEHDGET 676
VK++ P +G+T
Sbjct: 2046 SDASPPPVKIESSSPSVTEGQT 2067
Score = 55.5 bits (132), Expect = 7e-07
Identities = 46/167 (27%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV+VG V C GDP P V W G P + + G G + + + D
Sbjct: 3499 TVVVGHAVEFECLALGDPKPQVTWSKVGGH--LRPGIVQSG-------GVVRIAHVELAD 3549
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G Y C ++N ++ + +V+ L + + V G PC ++G P I
Sbjct: 3550 AGQYRCTATN-AAGTTQSHVLLLVQALPQISMPQEVR--VPAGSAAVFPCIASGYPTPDI 3606
Query: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
SW + L S L N L + V P+D G Y C A N G
Sbjct: 3607 SW-----SKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQG 3648
Score = 53.1 bits (126), Expect = 3e-06
Identities = 45/170 (26%), Positives = 66/170 (38%), Gaps = 12/170 (7%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG V L C G+P W + + + + L+D L++ A D
Sbjct: 3124 VKVGKAVTLECVSAGEPRSSARWTRISSTPAK---LEQRTYGLMDSHAVLQISSAKPSDA 3180
Query: 547 GVYHCISSNYDDADILTYRITV----VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
G Y C++ N + V + P Q TV G T L C +TG P
Sbjct: 3181 GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA 3240
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W + + +Q L TL I +V +D G Y C A +P+G
Sbjct: 3241 PTIHWSKLRSPLPWQHR-----LEGDTLIIPRVAQQDSGQYICNATSPAG 3285
Score = 52.8 bits (125), Expect = 5e-06
Identities = 30/91 (32%), Positives = 42/91 (46%), Gaps = 14/91 (15%)
Query: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM-----PDHSLLSTASKERTHGS 2581
PP++ P SI G CVA+GVP P I W + P H ++ S+
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG---- 460
Query: 2582 EQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
+GTL+I++ + SD G Y C A N G
Sbjct: 461 -----RGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 51.2 bits (121), Expect = 1e-05
Identities = 50/181 (27%), Positives = 71/181 (39%), Gaps = 40/181 (22%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSE---DGRILIDKSGKLELQM 540
E TV G T L C G P P + W SK+R+P + +G LI +
Sbjct: 3220 ELTVEAGHTATLRCSATGSPAPTIHW-----SKLRSPLPWQHRLEGDTLI-------IPR 3267
Query: 541 ADSFDTGVYHCISSN---YDDADIL------TYRITVVEPLVEAYQENGIHHTVFIGETL 591
D+G Y C +++ + +A I+ Y TV E H +V GET+
Sbjct: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE-----------HASVQAGETV 3316
Query: 592 DLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPS 651
L C + G P + W G+ S + N L + P+D G YRC N
Sbjct: 3317 QLQCLAHGTPPLTFQWSRVGS-----SLPGRATARNELLHFERAAPEDSGRYRCRVTNKV 3371
Query: 652 G 652
G
Sbjct: 3372 G 3372
Score = 49.7 bits (117), Expect = 4e-05
Identities = 23/82 (28%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Query: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTL 2491
P ++T +++ G++++ CV+ G+P P I W + G++ P++ GTL
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVT-VTSEGGRGTL 464
Query: 2492 VIKEATAYDRGNYICKAQNSVG 2513
+I++ D+G Y C+A N+ G
Sbjct: 465 IIRDVKESDQGAYTCEAMNARG 486
Score = 47.0 bits (110), Expect = 2e-04
Identities = 52/184 (28%), Positives = 74/184 (40%), Gaps = 24/184 (13%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G TV L C G P+ + W GS P + R I L + + D
Sbjct: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGS---LPPQARSERTDI---ATLLIPAITTADA 2020
Query: 547 GVYHCISSNYDDADILTYRITVV--------EPLVEAYQENGIHHTVFIGETLDLPCHST 598
G Y C++++ A RI VV P V+ + +V G+TLDL C
Sbjct: 2021 GFYLCVATS--PAGTAQARIQVVVLSASDASPPPVKIESSSP---SVTEGQTLDLNCVVA 2075
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIF 658
G A ++W G ++ + ++ LR+ QV+P D G Y C N SG
Sbjct: 2076 GSAHAQVTWYRRGGSLPPHTQ-----VHGSRLRLPQVSPADSGEYVCRVENGSGPKEASI 2130
Query: 659 QVSV 662
VSV
Sbjct: 2131 TVSV 2134
Score = 46.2 bits (108), Expect = 4e-04
Identities = 44/167 (26%), Positives = 64/167 (38%), Gaps = 18/167 (10%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G T+ LNC G V W GS + A + + L L D+
Sbjct: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGS-LPARHQTH--------GSLLRLHQVTPADS 2213
Query: 547 GVYHC----ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
G Y C S + + ++T +V+ + + TV G+TLDL C G
Sbjct: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAH 2273
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
A ++W G S + + L I Q +P D G Y C A+N
Sbjct: 2274 AQVTWYKRGG-----SLPARHQVRGSRLYIFQASPADAGQYVCRASN 2315
Score = 46.2 bits (108), Expect = 4e-04
Identities = 54/191 (28%), Positives = 75/191 (39%), Gaps = 31/191 (16%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G T+ LNC G V W GS P + L L L A D+
Sbjct: 2352 VAEGQTLDLNCVVPGQSHAQVTWHKRGGS---LPVRHQTHGSL------LRLYQASPADS 2402
Query: 547 GVYHCI---SSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI---------GETLDLP 594
G Y C SS +A +L +EP + G+ TV I G+TLDL
Sbjct: 2403 GEYVCRVLGSSVPLEASVLV----TIEP-AGSVPALGVTPTVRIESSSSQVAEGQTLDLN 2457
Query: 595 CHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
C G A ++W G ++ + ++ LR+LQVTP D G Y C SG
Sbjct: 2458 CLVAGQAHAQVTWHKRGGSLPARHQ-----VHGSRLRLLQVTPADSGEYVCRVVGSSGTQ 2512
Query: 655 FLIFQVSVKMK 665
V+++ +
Sbjct: 2513 EASVLVTIQQR 2523
Score = 46.2 bits (108), Expect = 4e-04
Identities = 52/178 (29%), Positives = 72/178 (40%), Gaps = 30/178 (16%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G T+ LNC G V W GS V +L L D+
Sbjct: 2448 VAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH---------GSRLRLLQVTPADS 2498
Query: 547 GVYHCI---SSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI---------GETLDLP 594
G Y C SS +A +L +T+ + L ++ + G+ + V I G TLDL
Sbjct: 2499 GEYVCRVVGSSGTQEASVL---VTIQQRLSGSHSQ-GVAYPVRIESSSASLANGHTLDLN 2554
Query: 595 CHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
C +I+W G ++ SR + V LRI QVTP D G Y C +N +G
Sbjct: 2555 CLVASQAPHTITWYKRGGSL---PSRHQIV--GSRLRIPQVTPADSGEYVCHVSNGAG 2607
Score = 46.2 bits (108), Expect = 4e-04
Identities = 67/314 (21%), Positives = 112/314 (35%), Gaps = 59/314 (18%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G T+ LNC G V W GS + +L L D+
Sbjct: 2738 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT---------RGSRLRLHHVSPADS 2788
Query: 547 GVYHCI---SSNYDDADILTYRITVVEPLVEAYQENGIH----------------HTVFI 587
G Y C SS +A +L +EA + +H V
Sbjct: 2789 GEYVCRVMGSSGPLEASVLV--------TIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
Query: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVA 647
G+TLDL C G A ++W G N+ + ++ LR+ QV+P D G Y C
Sbjct: 2841 GQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ-----VHGPLLRLNQVSPADSGEYSCQV 2895
Query: 648 ANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAE 707
SG V+++ P+ G + ++ S+ +H+ E G L + ++ +
Sbjct: 2896 TGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASS--SHVTE--GQTLDLNCVVPGQ 2951
Query: 708 VGKHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNA 767
+ ++T +RG S R + + + P + +A
Sbjct: 2952 A------------HAQVTWYKRGGSLPARHQTHGSQL--RLHLVSPADSGEYVCRAASGP 2997
Query: 768 MPDKRENTTVSPPP 781
P++ + TV+ PP
Sbjct: 2998 GPEQEASFTVTVPP 3011
Score = 45.8 bits (107), Expect = 6e-04
Identities = 45/168 (26%), Positives = 63/168 (37%), Gaps = 23/168 (13%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV G T+ L+C G V W GS V + +L + A D
Sbjct: 2255 TVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV---------RGSRLYIFQASPAD 2305
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIH--------HTVFIGETLDLPCHS 597
G Y C +SN +A I T +T + AY V G+TLDL C
Sbjct: 2306 AGQYVCRASNGMEASI-TVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVV 2364
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRC 645
G A ++W G ++ + + LR+ Q +P D G Y C
Sbjct: 2365 PGQSHAQVTWHKRGGSLPVRHQ-----THGSLLRLYQASPADSGEYVC 2407
Score = 44.3 bits (103), Expect = 0.002
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 12/89 (13%)
Query: 1744 PPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL-----ANQTVVSESSQGSRQAV 1798
PP+++ + I G TV C A G P+P + W L + V+ +S+G R
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR--- 461
Query: 1799 VTVDGTLVLHNLSIYDRGFYKCVASNPGG 1827
GTL++ ++ D+G Y C A N G
Sbjct: 462 ----GTLIIRDVKESDQGAYTCEAMNARG 486
Score = 44.3 bits (103), Expect = 0.002
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
PP ++ R+ I + G+++ C A G P P + W L+ G + T + G
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTS--EGGRG 462
Query: 1901 TLYIRNLASSDRGTYECIATSSTG 1924
TL IR++ SD+G Y C A ++ G
Sbjct: 463 TLIIRDVKESDQGAYTCEAMNARG 486
Score = 43.5 bits (101), Expect = 0.003
Identities = 46/179 (25%), Positives = 67/179 (37%), Gaps = 26/179 (14%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
+V G T+ LNC G V W GS P+ G +L L D
Sbjct: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL--PPHTQVHG-------SRLRLPQVSPAD 2111
Query: 546 TGVYHCISSNYDDADILTYRITVVE---------PLVEAYQENGIHHT---VFIGETLDL 593
+G Y C N + ++V+ P+ + + I + V G+TLDL
Sbjct: 2112 SGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDL 2171
Query: 594 PCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
C G A ++W G ++ + + LR+ QVTP D G Y C SG
Sbjct: 2172 NCVVPGQAHAQVTWHKRGGSLPARHQT-----HGSLLRLHQVTPADSGEYVCHVVGTSG 2225
Score = 42.4 bits (98), Expect = 0.006
Identities = 46/177 (25%), Positives = 65/177 (36%), Gaps = 26/177 (14%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV+ G T+ LNC P + W GS L L D
Sbjct: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQT---------HGSHLRLHQMSVAD 2690
Query: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI---------GETLDLPCH 596
+G Y C ++N DA + + V P + G + I GETLDL C
Sbjct: 2691 SGEYVCRANNNIDA-LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCV 2749
Query: 597 STGIPDASISWVIPGNNV-LYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
G A ++W G ++ + +R + LR+ V+P D G Y C SG
Sbjct: 2750 VPGQAHAQVTWHKRGGSLPSHHQTRGSR------LRLHHVSPADSGEYVCRVMGSSG 2800
Score = 39.7 bits (91), Expect = 0.040
Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 12/88 (13%)
Query: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRL-----PSKAVVDQQHRVGSWIHV 1995
P++ ++ + + G + C A G P P I WRL PS V G
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG----- 460
Query: 1996 YPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
G+L I V E D G Y C A N G
Sbjct: 461 --RGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 39.7 bits (91), Expect = 0.040
Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 4/108 (3%)
Query: 547 GVYHCISSN-YDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
G Y C++SN Y A + P V E + V +G+ + L C S G P +S
Sbjct: 3087 GTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVW--VKVGKAVTLECVSAGEPRSSA 3144
Query: 606 SWVIPGNNVLYQSSRDKKVLNN-GTLRILQVTPKDQGYYRCVAANPSG 652
W + R ++++ L+I P D G Y C+A N G
Sbjct: 3145 RWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALG 3192
Score = 37.4 bits (85), Expect = 0.20
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 10/87 (11%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWT----RVPSGLDLSKRKQNSRVQVL 1703
P++V S C A+G P P I+W +PS ++ + R
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR---- 461
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFG 1730
GTL I+ V+ D+G Y C A N G
Sbjct: 462 --GTLIIRDVKESDQGAYTCEAMNARG 486
Score = 37.0 bits (84), Expect = 0.26
Identities = 25/84 (29%), Positives = 31/84 (36%), Gaps = 1/84 (1%)
Query: 2337 PTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSF 2396
P P E I A G++ C G P P I W L N + P+ G+
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRL-NWGHIPSHPRVTVTSEGGRGTL 464
Query: 2397 IISKTTREDAGKYRCAARNKVGYI 2420
II D G Y C A N G +
Sbjct: 465 IIRDVKESDQGAYTCEAMNARGMV 488
Score = 37.0 bits (84), Expect = 0.26
Identities = 41/170 (24%), Positives = 59/170 (34%), Gaps = 16/170 (9%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
GG+ L C G P + W DG V + G + +L D GVY
Sbjct: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPS------GTQQRHQGSELHFPSVQPSDAGVY 1744
Query: 550 HCISSNYDDADILTYRITVVE----PLVEAYQENGIHHTVFIGETLDLPCHSTG-IPDAS 604
C N ++ + V E P+ +E +V G + C + P +
Sbjct: 1745 ICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQR-SQSVRPGADVTFICTAKSKSPAYT 1803
Query: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
+ W N L + D NG L I V D G Y C +N +D
Sbjct: 1804 LVWTRLHNGKLPTRAMDF----NGILTIRNVQLSDAGTYVCTGSNMFAMD 1849
Score = 36.6 bits (83), Expect = 0.34
Identities = 27/91 (29%), Positives = 42/91 (46%), Gaps = 7/91 (7%)
Query: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNN----GTLRILQVTPKDQGYY 643
G+T+ C + G+P I+W + ++ S + + + GTL I V DQG Y
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI---PSHPRVTVTSEGGRGTLIIRDVKESDQGAY 477
Query: 644 RCVAANPSGVDFLIFQVSVKMKGQRPLEHDG 674
C A N G+ F I +++ QR DG
Sbjct: 478 TCEAMNARGMVFGIPDGVLELVPQRGPCPDG 508
Score = 36.2 bits (82), Expect = 0.44
Identities = 40/167 (23%), Positives = 59/167 (35%), Gaps = 21/167 (12%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G T+ LNC + W GS + +L + D+G Y
Sbjct: 2548 GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV---------GSRLRIPQVTPADSGEY 2598
Query: 550 HCISSNYDDADILTYRITV-------VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
C SN + + +T+ V + + TV G+TLDL C P
Sbjct: 2599 VCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQ 2658
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
A I+W G S + + LR+ Q++ D G Y C A N
Sbjct: 2659 AIITWYKRGG-----SLPSRHQTHGSHLRLHQMSVADSGEYVCRANN 2700
Score = 35.8 bits (81), Expect = 0.57
Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 9/85 (10%)
Query: 2141 PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL-----PSNDMISFSIDRYTFHAN 2195
P++ + + + G T C G P P I W L PS+ ++ + +
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG----GR 461
Query: 2196 GSLTINKVKLLDSGEYVCVARNPSG 2220
G+L I VK D G Y C A N G
Sbjct: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
Score = 34.3 bits (77), Expect = 1.7
Identities = 46/188 (24%), Positives = 68/188 (36%), Gaps = 27/188 (14%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G T+ LNC G V W GS + A + + +L L + D+
Sbjct: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGS-LPARHQTH--------GSQLRLHLVSPADS 2986
Query: 547 GVYHC-ISSNYDDADILTYRITVVEPLVEAYQENGI-------HHTVFIGETLDLPC--H 596
G Y C +S ++ +TV +Y+ TV G+ C H
Sbjct: 2987 GEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIH 3046
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVL--NNGTLRILQVTPKDQGYYRCVAANPSGVD 654
P S+ W Q D + N + I+ P + G YRCVA+N GV
Sbjct: 3047 DGAAP-ISLEW-----KTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA 3100
Query: 655 FLIFQVSV 662
+ +SV
Sbjct: 3101 QSVVNLSV 3108
Score = 33.9 bits (76), Expect = 2.2
Identities = 24/79 (30%), Positives = 33/79 (41%), Gaps = 10/79 (12%)
Query: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNA-MQADDSGHRTRRYTLFNNGTLYFN 2107
Q G+ C A G P P I+W L G + ++ + G R GTL
Sbjct: 417 QASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR---------GTLIIR 467
Query: 2108 KVGVAEEGDYTCYAQNTLG 2126
V +++G YTC A N G
Sbjct: 468 DVKESDQGAYTCEAMNARG 486
Score = 33.9 bits (76), Expect = 2.2
Identities = 23/67 (34%), Positives = 31/67 (46%), Gaps = 11/67 (16%)
Query: 2259 FDCRAEGTPSPEVMWIM-----PDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFIC 2313
F C A G P+P + W + P + +T G R GTL IR+V+ SD + C
Sbjct: 426 FTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR------GTLIIRDVKESDQGAYTC 479
Query: 2314 VARNEGG 2320
A N G
Sbjct: 480 EAMNARG 486
Score = 33.1 bits (74), Expect = 3.7
Identities = 24/69 (34%), Positives = 29/69 (42%), Gaps = 9/69 (13%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADG---SKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
G TV C G PTP ++W L G S R SE GR G L ++ D
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR------GTLIIRDVKESDQ 474
Query: 547 GVYHCISSN 555
G Y C + N
Sbjct: 475 GAYTCEAMN 483
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 186 bits (471), Expect = 3e-46
Identities = 220/916 (24%), Positives = 364/916 (39%), Gaps = 77/916 (8%)
Query: 1724 SASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILAN 1783
S +N+F D LH +L V+ +E+ S + + C A G P T+ W LA
Sbjct: 11 SFANVFSED-LHSSLYFVN-------ASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLAT 62
Query: 1784 QTVVSESSQGSRQAVVTVDGTLVLH-------NLSIYDRGFYKCVASNPGGQ-DSLLVKI 1835
+ + G R V +GTL + + I+D +Y C A NP G+ S V I
Sbjct: 63 GEEIYDVP-GIRH--VHPNGTLQIFPFPPSSFSTLIHDNTYY-CTAENPSGKIRSQDVHI 118
Query: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLF 1895
+ + P + Q + G C + + + V + V + + S+
Sbjct: 119 KAVLREPYTVRVEDQKTMR--GNVAVFKCIIPSSVEAYITVVSWEKDTVSLV--SGSRFL 174
Query: 1896 LFSNGTLYIRNLASSDR-GTYECIA----TSSTGSERRVVMLTMEERVTSPRIEAASQKR 1950
+ S G LYI+++ + D Y CI T T + + ++P I R
Sbjct: 175 ITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHR 234
Query: 1951 TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD 2010
+ G ++ L C A G P+P W L ++ R + L I ++ D
Sbjct: 235 KAMA-GQRVELPCKALGHPEPDYRW-LKDNMPLELSGRFQKTVT-----GLLIENIRPSD 287
Query: 2011 SGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEI 2070
SG Y+C N+ G ++ + ++ +P K K + G + C +G+ E+
Sbjct: 288 SGSYVCEVSNRYGTAKVIGRLYVK-QPLKATISPRKVKSSV-GSQVSLSCSVTGTEDQEL 345
Query: 2071 SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEM 2130
SW +G ++N R T N+ L + + ++ G Y C+ + +
Sbjct: 346 SW-YRNGEILNPGKNV--------RITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQD 396
Query: 2131 KVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRY 2190
V + + P+I S + K + + L C V G P P I W L + ++ R
Sbjct: 397 YVQVVLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455
Query: 2191 T--FHANGS----LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNR 2244
+ + G+ L I+ ++ D G Y C A N +G +++V G + R
Sbjct: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV-------RGPASIR 508
Query: 2245 TVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVR 2304
+ TA+ + CR G P + W N+ P+ ++ NGTL++ +V+
Sbjct: 509 PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL---PFNHRQVAFENNGTLKLSDVQ 565
Query: 2305 LS-DSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSV-D 2362
D ++ C N + L V ++ P F PF E +G+ + C V
Sbjct: 566 KEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPF-EFPRFSIGQRVFIPCVVVS 621
Query: 2363 GNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEK 2422
G+ P I W +G I S IS + G Y C ARN+ +E
Sbjct: 622 GDLPITITW-QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEH 680
Query: 2423 LVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQ---I 2479
L + P + P GI G+++ L+C ++G P P I W G V + Q +
Sbjct: 681 QSQLIVRVPPKFVVQ-PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIAL 739
Query: 2480 NGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIV 2539
NG+ + NG+L+IK D G Y+CK N VG + + V P IT+ P ++
Sbjct: 740 NGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLA 799
Query: 2540 TRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSE-QLHLQGTLVIQNPQTS 2598
T+ G ++ C A G + WE D + ++ E + TL I
Sbjct: 800 TQ-GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRE 858
Query: 2599 DSGIYKCTAKNPLGSD 2614
DSG + C A N G D
Sbjct: 859 DSGFFSCHAINSYGED 874
Score = 177 bits (448), Expect = 2e-43
Identities = 219/918 (23%), Positives = 367/918 (39%), Gaps = 113/918 (12%)
Query: 1662 ANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSI------QRVEI 1715
+ + +PC A G P T+ W + +G ++ V PNGTL I +
Sbjct: 38 STTGTLVPCPAAGIPPVTLRW-YLATGEEIYDVPGIRHVH--PNGTLQIFPFPPSSFSTL 94
Query: 1716 QDRGQYLCSASNLFG---TDHLHVTLSV-VSYPPRILERRTKEITVHSGSTVELKCRAEG 1771
Y C+A N G + +H+ + Y R+ +++T G+ KC
Sbjct: 95 IHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMR-----GNVAVFKCIIPS 149
Query: 1772 RPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGF-YKCVA-------S 1823
+T + + VS S GSR ++T G L + ++ D + Y+C+ +
Sbjct: 150 SVEAYITVVSWEKDTVSLVS-GSR-FLITSTGALYIKDVQNEDGLYNYRCITRHRYTGET 207
Query: 1824 NPGGQDSLLVKIQVIAAPPVI--LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
L V +AP ++ + R+ + G+ ++LPC A G P+P W+ +
Sbjct: 208 RQSNSARLFVSDPANSAPSILDGFDHRKAMA----GQRVELPCKALGHPEPDYRWLKDN- 262
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
PL+ S F + L I N+ SD G+Y C ++ G+ + + L +++ P
Sbjct: 263 ---MPLEL--SGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQ----P 313
Query: 1942 RIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSL 2001
S ++ + + G ++ L+CS TG ++ W + + ++ + I+ + +L
Sbjct: 314 LKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGIN---HENL 370
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
+ + + D G Y C R + V L KI + K V + + C
Sbjct: 371 IMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKI-ISAFSEKVVSPAEPVSLMCN 429
Query: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHR-TRRYTLFNNGTLYFN--KVGVAEEGDYT 2118
G+P+P I+W+L D ++ HR ++ T N Y N V + G Y
Sbjct: 430 VKGTPLPTITWTLDDDPILKG------GSHRISQMITSEGNVVSYLNISSSQVRDGGVYR 483
Query: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
C A N+ G + + V A N T AG + C V G P I W
Sbjct: 484 CTANNSAGVVLYQARINVRGPASIRPMKNIT---AIAGRDTYIHCRVIGYPYYSIKWYKN 540
Query: 2179 SNDMISFSIDRYTFHANGSLTINKV-KLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
SN ++ F+ + F NG+L ++ V K +D GEY C T V PP I
Sbjct: 541 SN-LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFI 599
Query: 2238 NGL------YTNRTVIKATAVRHSKK-HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRI 2290
R I V + +G P P + + DNI T+
Sbjct: 600 QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS------- 652
Query: 2291 TVHKNGTLEIRNVRLSDSADFICVARNEGG----ESVLVVQLEVLEMLRRPTFRNPFNEK 2346
+L I N+ L + ++ C+ARNE +S L+V++ + + +P ++
Sbjct: 653 ------SLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP-KFVVQPRDQDGI--- 702
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGT---RFSNGPQSYQYLIASNGSFIISKTTR 2403
GK+ LNCS +G P P I+W G +F + + + SNGS +I
Sbjct: 703 ----YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVE 758
Query: 2404 EDAGKYRCAARNKVGY-IEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKP 2462
ED+G Y C N VG + K + L + + P ++T P T G+ + C + G
Sbjct: 759 EDSGYYLCKVSNDVGADVSKSMYLTV-KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI 817
Query: 2463 NIKWTMP--------SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGH 2514
++W + Y+V ++ + I TL I D G + C A NS G
Sbjct: 818 IVRWEKEDRIINPEMARYLVSTKEVGEEVI----STLQILPTVREDSGFFSCHAINSYGE 873
Query: 2515 T--LITVPVMIVAYPPRI 2530
+I + V PP I
Sbjct: 874 DRGIIQLTVQEPPDPPEI 891
Score = 135 bits (341), Expect = 4e-31
Identities = 209/944 (22%), Positives = 359/944 (38%), Gaps = 138/944 (14%)
Query: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQ 1716
+ T A D ++ C +G P +I W + + L + R +V NGTL + V+ +
Sbjct: 512 NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR----QVAFENNGTLKLSDVQKE 567
Query: 1717 -DRGQYLCSA---SNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGR 1772
D G+Y C+ L + +HVT+ V PP I ++ G V + C
Sbjct: 568 VDEGEYTCNVLVQPQLSTSQSVHVTVKV---PPFIQPFEFPRFSI--GQRVFIPCVVVSG 622
Query: 1773 PSP-TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSL 1831
P T+TW + + S G + +L + NLS+ G Y C+A N
Sbjct: 623 DLPITITWQKDGRPI--PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEH 680
Query: 1832 LVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQ--F 1889
++ V P +++ R Q G +G+++ L C+A+G P P++ W S G V Q
Sbjct: 681 QSQLIVRVPPKFVVQPRDQ--DGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIA 738
Query: 1890 TNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQK 1949
N ++ + SNG+L I+++ D G Y C ++ G++ V +M V P + +
Sbjct: 739 LNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGAD---VSKSMYLTVKIPAMITSYPN 795
Query: 1950 RTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHR-------VGSWIHVYPNGSLF 2002
T G K ++C+A GE + W + + + R VG + +L
Sbjct: 796 TTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEV----ISTLQ 851
Query: 2003 IGSVTEKDSGVYLCVARNKMGDD--LILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDC 2060
I +DSG + C A N G+D +I + V P +I+ K + + D
Sbjct: 852 ILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFD- 910
Query: 2061 KASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYT-LFNNGTLYFNKVGVAEEGDYT- 2118
SP+ N + DS RT+ + N+ T+ + + Y+
Sbjct: 911 --GNSPITGYD------IECKNKSDSWDSAQRTKDVSPQLNSATI----IDIHPSSTYSI 958
Query: 2119 -CYAQNTLGKDEMKVHLTVIT--AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFW 2175
YA+N +GK E LT+ AAP G + E ++ W
Sbjct: 959 RMYAKNRIGKSEPSNELTITADEAAP-------------DGPPQEVHLEPISSQSIRVTW 1005
Query: 2176 LLP----SNDMI-SFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
P N +I + I + G+ N + + SG D+++Y LD
Sbjct: 1006 KAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSG------------DSEVYTLDN 1053
Query: 2231 VSKPPLINGLY-----------TNRTVIKAT---AVRHSKKHFDCRAEGTPSPEVMWIMP 2276
++K GL +++ +I T + ++ A S + W
Sbjct: 1054 LNKFTQY-GLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTL 1112
Query: 2277 DNIFLTAPYYGSRITVHKN---GTL-EIRNVRLSDSADFICVARNEGGESVLVVQLEVLE 2332
L G R+ N G L EI+N+ + + +G E ++VL
Sbjct: 1113 SKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS-----LELDGLEKYTNYSIQVLA 1167
Query: 2333 MLR-------RPTFRNPFNEKIVAQLG-KSTALNCS---VDGNPPPEIIWILPNGTRFSN 2381
R F + G K+ A + S V PP ++ I+ T F +
Sbjct: 1168 FTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCS 1227
Query: 2382 ------------GPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIG 2429
P S+ Y I + +S+ + + + E + + +
Sbjct: 1228 HPYPTVISEFEASPDSFSYRIPN-----LSRNRQYSVWVVAVTSAGRGNSSEIITVEPLA 1282
Query: 2430 QKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG 2489
+ P + GTV + + L C + G P P +KW S I+G+ + NG
Sbjct: 1283 KAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNG 1342
Query: 2490 TLVIKEATAYDRGNYICKAQNSVG--HTLITVPVMIVAYPPRIT 2531
+ +I+ A D G Y C A N+ G ++ + V + PR+T
Sbjct: 1343 SFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLT 1386
Score = 66.6 bits (161), Expect = 3e-10
Identities = 35/133 (26%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
Query: 1821 VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
V S G S ++ ++ +A P + + W + + LPC A G P P+V W + D
Sbjct: 1264 VTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKW-MKD 1322
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
L + + +FSNG+ IR + + D G Y CIA ++ GS+ ++ L ++
Sbjct: 1323 SNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQ 1382
Query: 1941 PRIEAASQKRTEV 1953
PR+ + + +
Sbjct: 1383 PRLTVSKTTSSSI 1395
Score = 58.5 bits (140), Expect = 8e-08
Identities = 33/105 (31%), Positives = 55/105 (52%), Gaps = 3/105 (2%)
Query: 1655 AASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVE 1714
+ + T P D LPC+AVG+P P + W + +G S + R + NG+ I+ V+
Sbjct: 1292 SGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTP-SLVTIDGRRSIFSNGSFIIRTVK 1350
Query: 1715 IQDRGQYLCSASNLFGTDHLHVTLSVVSYP--PRILERRTKEITV 1757
+D G Y C A+N +G+D + + L V P PR+ +T ++
Sbjct: 1351 AEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSI 1395
Score = 55.8 bits (133), Expect = 5e-07
Identities = 47/185 (25%), Positives = 83/185 (44%), Gaps = 12/185 (6%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKV-RAPYVSEDGRILIDKSGKLELQMADSFDT 546
+ G V LNC +G P P + W + G+ V + ++ +GRI + +G L ++ D+
Sbjct: 702 IYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDS 761
Query: 547 GVYHCISSNYDDADILT--YRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
G Y C SN AD+ Y + ++ +Y + G+ ++ C + G
Sbjct: 762 GYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQ---GQKKEMSCTAHGEKPII 818
Query: 605 ISWVIPGNNVLYQSSR----DKKVLNN--GTLRILQVTPKDQGYYRCVAANPSGVDFLIF 658
+ W + + +R K+V TL+IL +D G++ C A N G D I
Sbjct: 819 VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGII 878
Query: 659 QVSVK 663
Q++V+
Sbjct: 879 QLTVQ 883
Score = 54.3 bits (129), Expect = 2e-06
Identities = 47/169 (27%), Positives = 69/169 (40%), Gaps = 15/169 (8%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLAD------GSKVRAPYVSEDGRILIDKSGKLE 537
E V V L C +G P P + W L D GS + ++ +G ++ L
Sbjct: 415 EKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV----SYLN 470
Query: 538 LQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHS 597
+ + D GVY C ++N + RI V P +N T G + C
Sbjct: 471 ISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN---ITAIAGRDTYIHCRV 527
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPK-DQGYYRC 645
G P SI W +N+L + R NNGTL++ V + D+G Y C
Sbjct: 528 IGYPYYSIKW-YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/127 (24%), Positives = 62/127 (48%), Gaps = 5/127 (3%)
Query: 1736 VTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSR 1795
+T+ ++ P + + +T + L C+A G PSP V W+ + S + R
Sbjct: 1276 ITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGR 1335
Query: 1796 QAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGT 1855
+++ + +G+ ++ + D G+Y C+A+N G D +++ +QV P +Q R + T
Sbjct: 1336 RSIFS-NGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP----DQPRLTVSKT 1390
Query: 1856 WGESLKL 1862
S+ L
Sbjct: 1391 TSSSITL 1397
Score = 50.4 bits (119), Expect = 2e-05
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 566 ITVVEPLVEAYQE----NGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNV--LYQSS 619
I VEPL +A +G T ++ + + LPC + G P ++ W+ N L
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIV-LPCKAVGDPSPAVKWMKDSNGTPSLVTID 1333
Query: 620 RDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGS 679
+ + +NG+ I V +D GYY C+A N G D +I + V++ +P +T S
Sbjct: 1334 GRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSS 1393
Query: 680 GL 681
+
Sbjct: 1394 SI 1395
Score = 48.9 bits (115), Expect = 7e-05
Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 9/102 (8%)
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
KD + CKA G P P + W + D + + D R ++F+NG+ V +
Sbjct: 1301 KDIVLPCKAVGDPSPAVKW-MKDSNGTPSLVTIDG------RRSIFSNGSFIIRTVKAED 1353
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITA--APRIRQSNKTNKRI 2153
G Y+C A N G DE+ ++L V PR+ S T+ I
Sbjct: 1354 SGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSI 1395
Score = 47.0 bits (110), Expect = 2e-04
Identities = 50/202 (24%), Positives = 82/202 (40%), Gaps = 34/202 (16%)
Query: 489 VGGTVGLNCPGQGDPTPHVDW-----LLADGSKVRAPYVSEDGRILIDKSGKLELQMADS 543
VG V L+C G + W +L G VR ++ + I+ M S
Sbjct: 327 VGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMD--------HMVKS 378
Query: 544 FDTGVYHCISSNYDDADILTYRITVVEP----LVEAYQENGIHHTVFIGETLDLPCHSTG 599
D G Y C D Y V+E ++ A+ E V E + L C+ G
Sbjct: 379 -DGGAYQCFVRK-DKLSAQDYVQVVLEDGTPKIISAFSEK----VVSPAEPVSLMCNVKG 432
Query: 600 IPDASISWVIPGNNVLYQSSR--DKKVLNNGT----LRILQVTPKDQGYYRCVAANPSGV 653
P +I+W + + +L S + + + G L I +D G YRC A N +GV
Sbjct: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
Query: 654 DFLIFQVSVKMKGQ---RPLEH 672
+++Q + ++G RP+++
Sbjct: 493 --VLYQARINVRGPASIRPMKN 512
Score = 45.4 bits (106), Expect = 7e-04
Identities = 38/134 (28%), Positives = 60/134 (44%), Gaps = 15/134 (11%)
Query: 530 IDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEP---LVEAYQENGIHHTVF 586
ID + L + G Y CI+ N A ++ V P +V+ ++GI+
Sbjct: 648 IDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIY---- 703
Query: 587 IGETLDLPCHSTGIPDASISWV------IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQ 640
G+ + L C + G P +I W +P + + R + VL+NG+L I V +D
Sbjct: 704 -GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQ-VLSNGSLLIKHVVEEDS 761
Query: 641 GYYRCVAANPSGVD 654
GYY C +N G D
Sbjct: 762 GYYLCKVSNDVGAD 775
Score = 45.4 bits (106), Expect = 7e-04
Identities = 32/107 (29%), Positives = 45/107 (42%), Gaps = 11/107 (10%)
Query: 2516 LITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASK 2575
L P I+ + +T + IV L C A+G P P + W M D + T S
Sbjct: 1281 LAKAPARILTFSGTVTTPWMKDIV--------LPCKAVGDPSPAVKW-MKDSN--GTPSL 1329
Query: 2576 ERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G + G+ +I+ + DSG Y C A N GSD +QV
Sbjct: 1330 VTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV 1376
Score = 44.3 bits (103), Expect = 0.002
Identities = 46/165 (27%), Positives = 67/165 (40%), Gaps = 23/165 (13%)
Query: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
+ G V L C G P P WL K P + GR +G L + S D+G
Sbjct: 237 MAGQRVELPCKALGHPEPDYRWL-----KDNMP-LELSGRFQKTVTGLLIENIRPS-DSG 289
Query: 548 VYHC-ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
Y C +S+ Y A ++ R+ V +PL + +V G + L C TG D +S
Sbjct: 290 SYVCEVSNRYGTAKVIG-RLYVKQPLKATISPRKVKSSV--GSQVSLSCSVTGTEDQELS 346
Query: 607 W------VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRC 645
W + PG NV +N+ L + + D G Y+C
Sbjct: 347 WYRNGEILNPGKNVRITG------INHENLIMDHMVKSDGGAYQC 385
Score = 41.6 bits (96), Expect = 0.010
Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 9/80 (11%)
Query: 581 IHHTVFIGETLDL-PCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPK- 638
+ VF T L PC + GIP ++ W + +Y + V NGTL+I P
Sbjct: 31 LQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSS 90
Query: 639 ------DQGYYRCVAANPSG 652
D YY C A NPSG
Sbjct: 91 FSTLIHDNTYY-CTAENPSG 109
Score = 41.2 bits (95), Expect = 0.014
Identities = 39/144 (27%), Positives = 65/144 (45%), Gaps = 11/144 (7%)
Query: 527 RILIDKSGKLELQMADSFDTGVYH--CISSNYDDADIL---TYRITVVEPLVEAYQ--EN 579
R LI +G L ++ + D G+Y+ CI+ + + + R+ V +P A +
Sbjct: 172 RFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDG 230
Query: 580 GIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKD 639
H G+ ++LPC + G P+ W + N L S R +K + L I + P D
Sbjct: 231 FDHRKAMAGQRVELPCKALGHPEPDYRW-LKDNMPLELSGRFQKTVTG--LLIENIRPSD 287
Query: 640 QGYYRCVAANPSGVDFLIFQVSVK 663
G Y C +N G +I ++ VK
Sbjct: 288 SGSYVCEVSNRYGTAKVIGRLYVK 311
Score = 40.4 bits (93), Expect = 0.023
Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L C GDP+P V W+ S V+ DGR I +G ++ + D+G Y CI++
Sbjct: 1305 LPCKAVGDPSPAVKWM--KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
Query: 555 NYDDADILTYRITVVEP 571
N +D + + V P
Sbjct: 1363 NNWGSDEIILNLQVQVP 1379
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 172 bits (436), Expect = 4e-42
Identities = 172/686 (25%), Positives = 277/686 (40%), Gaps = 88/686 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
PP I+E +IV GE L C A+G P P++ W S L +G
Sbjct: 28 PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 1901 TLYIRNLASS-----DRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQK 1949
+L+ + D G Y C+A + G + V +L + R + A
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA--- 143
Query: 1950 RTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
G+ ++ C G P+P I W+ + D+ R+ G L I +
Sbjct: 144 -----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI-----TIRGGKLMITYTRK 193
Query: 2009 KDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
D+G Y+CV N +G+ + + +++ +P+ + V +F+ C+A G PV
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK--CEARGDPV 251
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P + W DG + + RY + ++ TL KV + G YTC A+N +GK
Sbjct: 252 PTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2128 DEMKVHLTV-ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
E LTV + + P ++ + G T CE TG+P+P IFW + + FS
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 359
Query: 2187 I------DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD-DTKMY--KLDVVS--KPP 2235
R++ G LTI V+ D G Y+C N +G TK Y DV++ PP
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Query: 2236 LINGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK 2294
+I N+TV + T V C A G+P P ++W D + ++ SRI +
Sbjct: 420 VIRQGPVNQTVAVDGTFV------LSCVATGSPVPTILW-RKDGVLVST--QDSRIKQLE 470
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
NG L+IR +L D+ + C+A GE+ +EV E + Q +
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF------------GVPVQPPRP 518
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAAR 2414
T N PE+ + N S P A+ S+II + ++ A
Sbjct: 519 TDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG--ATPTSYIIEAFSHASGSSWQTVAE 576
Query: 2415 NKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVV 2474
N + L+ + L A GIS S +SD + ++ +P+ V
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRA-ANAYGISDPSQ----ISDPVKTQDV---LPTSQGV 628
Query: 2475 DRPQIN---GKYILHDNGTLVIKEAT 2497
D Q+ G +LH + V+ ++
Sbjct: 629 DHKQVQRELGNAVLHLHNPTVLSSSS 654
Score = 163 bits (412), Expect = 2e-39
Identities = 147/517 (28%), Positives = 216/517 (41%), Gaps = 48/517 (9%)
Query: 1722 LCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL 1781
LCS S L D +PPRI+E + ++ V G L C+AEGRP+PT+ W
Sbjct: 16 LCSGSRLRQED----------FPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Query: 1782 ANQTVVSESSQGSRQAVVTVDGTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKI 1835
+ V ++ ++ G+L ++H S D G Y CVA N G+ S +
Sbjct: 65 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL 124
Query: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+V + V+V GE + C +G P+P++ W DG+ PL + ++
Sbjct: 125 EVAILRDDFRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISW-KKDGS---PLDDKDERI 179
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGS-ERRVVMLTMEERVTSPRIEAASQKRTEV 1953
+ G L I SD G Y C+ T+ G E V LT+ ER + + V
Sbjct: 180 TI-RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK----RPSNLAV 234
Query: 1954 NFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV 2013
D C A G+P P + WR D S + + +L I VT D G
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWR------KDDGELPKSRYEIRDDHTLKIRKVTAGDMGS 288
Query: 2014 YLCVARNKMG--DDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPEI 2070
Y CVA N +G + + V + +P K R QV+ G+ C+A+G+P P I
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKP--RDQVVALGRTVTFQCEATGNPQPAI 346
Query: 2071 SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEM 2130
W + + Q S + R+++ G L V ++ G Y C N G
Sbjct: 347 FWRREGSQNLLFSYQPPQS---SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403
Query: 2131 KVHLTVITA----APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
K +L V P + + N+ + T VL C TG P P I W ++S
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQ 462
Query: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDT 2223
R NG L I KL D+G Y C+A PSG+ T
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Score = 152 bits (384), Expect = 4e-36
Identities = 125/503 (24%), Positives = 203/503 (40%), Gaps = 39/503 (7%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + A L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 29 PRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G H V+ + ++ V G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
++C+ G P PT++W + + + + G L++ D G Y CV
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G ++S + ++ V+ P + +R + T +S + C A+G P P+V W D
Sbjct: 203 GTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
G + S+ + + TL IR + + D G+Y C+A + G LT++
Sbjct: 261 G------ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIHVYP 1997
P + + V G + C ATG P+P I WR + Q + S V
Sbjct: 315 PHFVVKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS----LRLKPAKIDHKQYFRKQVLHG 2053
G L I +V D G Y+C N G + ++ + +P + + + V
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
F + C A+GSPVP I W DG +++ + R NG L + +
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQIRYAKLGD 483
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTV 2136
G YTC A G+ ++ V
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEV 506
Score = 139 bits (349), Expect = 5e-32
Identities = 136/499 (27%), Positives = 198/499 (39%), Gaps = 61/499 (12%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ A L+C+ G P P I W + + D H +GSL ++
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWY-KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 2204 KLLDSGEYVCVARNPSGD--------DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
D G YVCVARN G+ + + + D P + V++ R
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPR-- 156
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
G P P + W + RIT+ + G L I R SD+ ++CV
Sbjct: 157 ---------GHPEPTISWKKDGS---PLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 203
Query: 2316 RNEGGESVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N GE V +L VLE RP+F + P N + + S C G+P P + W
Sbjct: 204 TNMVGERESEVAELTVLE---RPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVIL--EIGQK 2431
+G P+S +Y I + + I K T D G Y C A N VG E L ++G +
Sbjct: 259 DDGEL----PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG----YVVDRPQINGKYILHD 2487
P P G +++ C + G P+P I W + PQ + ++ +
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTG 2543
G L I D G YIC+ N G + + V +I PP + + P +
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2544 AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
F L CVA G P P I W D L+ST +QL G L I+ + D+G Y
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR----IKQLE-NGVLQIRYAKLGDTGRY 487
Query: 2604 KCTAKNPLGSDYAATYIQV 2622
C A P G + YI+V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 70.5 bits (171), Expect = 2e-11
Identities = 49/175 (28%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYV--SEDGRILIDKSGKLELQMA 541
+ V +G TV C G+P P + W + Y R + ++G L +
Sbjct: 323 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVE----AYQENGIHHTVFIGETLDLPCHS 597
D G Y C + N + I + V + + + ++ ++ TV + T L C +
Sbjct: 383 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 442
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P +I W G V Q SR K+ L NG L+I D G Y C+A+ PSG
Sbjct: 443 TGSPVPTILWRKDGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 62.0 bits (149), Expect = 7e-09
Identities = 49/176 (27%), Positives = 73/176 (41%), Gaps = 20/176 (11%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V + C +GDP P V W DG ++ Y D L+++ + D
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH-------TLKIRKVTAGDM 286
Query: 547 GVYHCISSNY----DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
G Y C++ N + + LT ++ P + + V +G T+ C +TG P
Sbjct: 287 GSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV---VALGRTVTFQCEATGNPQ 343
Query: 603 ASISWVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W G+ N+L+ QSS V G L I V D GYY C N +G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 399
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 11/170 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W G +V ++ SG L
Sbjct: 43 GEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D GVY C++ NY + V L + +++N V +GE + C G P+
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 604 SISWVIPGNNVLYQSSRDKKV-LNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ISW G+ + +D+++ + G L I D G Y CV N G
Sbjct: 162 TISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ TV V GT L+C G P P + W DG V ++D RI ++G L+++ A
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVS----TQDSRIKQLENGVLQIRYAK 480
Query: 543 SFDTGVYHCISS 554
DTG Y CI+S
Sbjct: 481 LGDTGRYTCIAS 492
Score = 41.6 bits (96), Expect = 0.010
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 8/92 (8%)
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
+PPRI P IV++ G L+C A G P P I W + + R+H L
Sbjct: 27 FPPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH--RMLL 83
Query: 2586 LQGTL-----VIQNPQTSDSGIYKCTAKNPLG 2612
G+L V D G+Y C A+N LG
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 172 bits (436), Expect = 4e-42
Identities = 172/686 (25%), Positives = 277/686 (40%), Gaps = 88/686 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
PP I+E +IV GE L C A+G P P++ W S L +G
Sbjct: 28 PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 1901 TLYIRNLASS-----DRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQK 1949
+L+ + D G Y C+A + G + V +L + R + A
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA--- 143
Query: 1950 RTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
G+ ++ C G P+P I W+ + D+ R+ G L I +
Sbjct: 144 -----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI-----TIRGGKLMITYTRK 193
Query: 2009 KDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
D+G Y+CV N +G+ + + +++ +P+ + V +F+ C+A G PV
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK--CEARGDPV 251
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P + W DG + + RY + ++ TL KV + G YTC A+N +GK
Sbjct: 252 PTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2128 DEMKVHLTV-ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
E LTV + + P ++ + G T CE TG+P+P IFW + + FS
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 359
Query: 2187 I------DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD-DTKMY--KLDVVS--KPP 2235
R++ G LTI V+ D G Y+C N +G TK Y DV++ PP
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Query: 2236 LINGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK 2294
+I N+TV + T V C A G+P P ++W D + ++ SRI +
Sbjct: 420 VIRQGPVNQTVAVDGTFV------LSCVATGSPVPTILW-RKDGVLVST--QDSRIKQLE 470
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
NG L+IR +L D+ + C+A GE+ +EV E + Q +
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF------------GVPVQPPRP 518
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAAR 2414
T N PE+ + N S P A+ S+II + ++ A
Sbjct: 519 TDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG--ATPTSYIIEAFSHASGSSWQTVAE 576
Query: 2415 NKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVV 2474
N + L+ + L A GIS S +SD + ++ +P+ V
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRA-ANAYGISDPSQ----ISDPVKTQDV---LPTSQGV 628
Query: 2475 DRPQIN---GKYILHDNGTLVIKEAT 2497
D Q+ G +LH + V+ ++
Sbjct: 629 DHKQVQRELGNAVLHLHNPTVLSSSS 654
Score = 163 bits (412), Expect = 2e-39
Identities = 147/517 (28%), Positives = 216/517 (41%), Gaps = 48/517 (9%)
Query: 1722 LCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL 1781
LCS S L D +PPRI+E + ++ V G L C+AEGRP+PT+ W
Sbjct: 16 LCSGSRLRQED----------FPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Query: 1782 ANQTVVSESSQGSRQAVVTVDGTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKI 1835
+ V ++ ++ G+L ++H S D G Y CVA N G+ S +
Sbjct: 65 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL 124
Query: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+V + V+V GE + C +G P+P++ W DG+ PL + ++
Sbjct: 125 EVAILRDDFRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISW-KKDGS---PLDDKDERI 179
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGS-ERRVVMLTMEERVTSPRIEAASQKRTEV 1953
+ G L I SD G Y C+ T+ G E V LT+ ER + + V
Sbjct: 180 TI-RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK----RPSNLAV 234
Query: 1954 NFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV 2013
D C A G+P P + WR D S + + +L I VT D G
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWR------KDDGELPKSRYEIRDDHTLKIRKVTAGDMGS 288
Query: 2014 YLCVARNKMG--DDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPEI 2070
Y CVA N +G + + V + +P K R QV+ G+ C+A+G+P P I
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKP--RDQVVALGRTVTFQCEATGNPQPAI 346
Query: 2071 SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEM 2130
W + + Q S + R+++ G L V ++ G Y C N G
Sbjct: 347 FWRREGSQNLLFSYQPPQS---SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403
Query: 2131 KVHLTVITA----APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
K +L V P + + N+ + T VL C TG P P I W ++S
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQ 462
Query: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDT 2223
R NG L I KL D+G Y C+A PSG+ T
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Score = 152 bits (384), Expect = 4e-36
Identities = 125/503 (24%), Positives = 203/503 (40%), Gaps = 39/503 (7%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + A L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 29 PRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G H V+ + ++ V G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
++C+ G P PT++W + + + + G L++ D G Y CV
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G ++S + ++ V+ P + +R + T +S + C A+G P P+V W D
Sbjct: 203 GTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
G + S+ + + TL IR + + D G+Y C+A + G LT++
Sbjct: 261 G------ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIHVYP 1997
P + + V G + C ATG P+P I WR + Q + S V
Sbjct: 315 PHFVVKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS----LRLKPAKIDHKQYFRKQVLHG 2053
G L I +V D G Y+C N G + ++ + +P + + + V
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
F + C A+GSPVP I W DG +++ + R NG L + +
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQIRYAKLGD 483
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTV 2136
G YTC A G+ ++ V
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEV 506
Score = 139 bits (349), Expect = 5e-32
Identities = 136/499 (27%), Positives = 198/499 (39%), Gaps = 61/499 (12%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ A L+C+ G P P I W + + D H +GSL ++
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWY-KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 2204 KLLDSGEYVCVARNPSGD--------DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
D G YVCVARN G+ + + + D P + V++ R
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPR-- 156
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
G P P + W + RIT+ + G L I R SD+ ++CV
Sbjct: 157 ---------GHPEPTISWKKDGS---PLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 203
Query: 2316 RNEGGESVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N GE V +L VLE RP+F + P N + + S C G+P P + W
Sbjct: 204 TNMVGERESEVAELTVLE---RPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVIL--EIGQK 2431
+G P+S +Y I + + I K T D G Y C A N VG E L ++G +
Sbjct: 259 DDGEL----PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG----YVVDRPQINGKYILHD 2487
P P G +++ C + G P+P I W + PQ + ++ +
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTG 2543
G L I D G YIC+ N G + + V +I PP + + P +
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2544 AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
F L CVA G P P I W D L+ST +QL G L I+ + D+G Y
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR----IKQLE-NGVLQIRYAKLGDTGRY 487
Query: 2604 KCTAKNPLGSDYAATYIQV 2622
C A P G + YI+V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 70.5 bits (171), Expect = 2e-11
Identities = 49/175 (28%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYV--SEDGRILIDKSGKLELQMA 541
+ V +G TV C G+P P + W + Y R + ++G L +
Sbjct: 323 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVE----AYQENGIHHTVFIGETLDLPCHS 597
D G Y C + N + I + V + + + ++ ++ TV + T L C +
Sbjct: 383 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 442
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P +I W G V Q SR K+ L NG L+I D G Y C+A+ PSG
Sbjct: 443 TGSPVPTILWRKDGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 62.0 bits (149), Expect = 7e-09
Identities = 49/176 (27%), Positives = 73/176 (41%), Gaps = 20/176 (11%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V + C +GDP P V W DG ++ Y D L+++ + D
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH-------TLKIRKVTAGDM 286
Query: 547 GVYHCISSNY----DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
G Y C++ N + + LT ++ P + + V +G T+ C +TG P
Sbjct: 287 GSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV---VALGRTVTFQCEATGNPQ 343
Query: 603 ASISWVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W G+ N+L+ QSS V G L I V D GYY C N +G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 399
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 11/170 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W G +V ++ SG L
Sbjct: 43 GEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D GVY C++ NY + V L + +++N V +GE + C G P+
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 604 SISWVIPGNNVLYQSSRDKKV-LNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ISW G+ + +D+++ + G L I D G Y CV N G
Sbjct: 162 TISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ TV V GT L+C G P P + W DG V ++D RI ++G L+++ A
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVS----TQDSRIKQLENGVLQIRYAK 480
Query: 543 SFDTGVYHCISS 554
DTG Y CI+S
Sbjct: 481 LGDTGRYTCIAS 492
Score = 41.6 bits (96), Expect = 0.010
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 8/92 (8%)
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
+PPRI P IV++ G L+C A G P P I W + + R+H L
Sbjct: 27 FPPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH--RMLL 83
Query: 2586 LQGTL-----VIQNPQTSDSGIYKCTAKNPLG 2612
G+L V D G+Y C A+N LG
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 172 bits (436), Expect = 4e-42
Identities = 172/686 (25%), Positives = 277/686 (40%), Gaps = 88/686 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
PP I+E +IV GE L C A+G P P++ W S L +G
Sbjct: 28 PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 1901 TLYIRNLASS-----DRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQK 1949
+L+ + D G Y C+A + G + V +L + R + A
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA--- 143
Query: 1950 RTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
G+ ++ C G P+P I W+ + D+ R+ G L I +
Sbjct: 144 -----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI-----TIRGGKLMITYTRK 193
Query: 2009 KDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
D+G Y+CV N +G+ + + +++ +P+ + V +F+ C+A G PV
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK--CEARGDPV 251
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P + W DG + + RY + ++ TL KV + G YTC A+N +GK
Sbjct: 252 PTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2128 DEMKVHLTV-ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
E LTV + + P ++ + G T CE TG+P+P IFW + + FS
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 359
Query: 2187 I------DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD-DTKMY--KLDVVS--KPP 2235
R++ G LTI V+ D G Y+C N +G TK Y DV++ PP
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Query: 2236 LINGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK 2294
+I N+TV + T V C A G+P P ++W D + ++ SRI +
Sbjct: 420 VIRQGPVNQTVAVDGTFV------LSCVATGSPVPTILW-RKDGVLVST--QDSRIKQLE 470
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
NG L+IR +L D+ + C+A GE+ +EV E + Q +
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF------------GVPVQPPRP 518
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAAR 2414
T N PE+ + N S P A+ S+II + ++ A
Sbjct: 519 TDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG--ATPTSYIIEAFSHASGSSWQTVAE 576
Query: 2415 NKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVV 2474
N + L+ + L A GIS S +SD + ++ +P+ V
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRA-ANAYGISDPSQ----ISDPVKTQDV---LPTSQGV 628
Query: 2475 DRPQIN---GKYILHDNGTLVIKEAT 2497
D Q+ G +LH + V+ ++
Sbjct: 629 DHKQVQRELGNAVLHLHNPTVLSSSS 654
Score = 163 bits (412), Expect = 2e-39
Identities = 147/517 (28%), Positives = 216/517 (41%), Gaps = 48/517 (9%)
Query: 1722 LCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL 1781
LCS S L D +PPRI+E + ++ V G L C+AEGRP+PT+ W
Sbjct: 16 LCSGSRLRQED----------FPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Query: 1782 ANQTVVSESSQGSRQAVVTVDGTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKI 1835
+ V ++ ++ G+L ++H S D G Y CVA N G+ S +
Sbjct: 65 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL 124
Query: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+V + V+V GE + C +G P+P++ W DG+ PL + ++
Sbjct: 125 EVAILRDDFRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISW-KKDGS---PLDDKDERI 179
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGS-ERRVVMLTMEERVTSPRIEAASQKRTEV 1953
+ G L I SD G Y C+ T+ G E V LT+ ER + + V
Sbjct: 180 TI-RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK----RPSNLAV 234
Query: 1954 NFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV 2013
D C A G+P P + WR D S + + +L I VT D G
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWR------KDDGELPKSRYEIRDDHTLKIRKVTAGDMGS 288
Query: 2014 YLCVARNKMG--DDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPEI 2070
Y CVA N +G + + V + +P K R QV+ G+ C+A+G+P P I
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKP--RDQVVALGRTVTFQCEATGNPQPAI 346
Query: 2071 SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEM 2130
W + + Q S + R+++ G L V ++ G Y C N G
Sbjct: 347 FWRREGSQNLLFSYQPPQS---SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403
Query: 2131 KVHLTVITA----APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
K +L V P + + N+ + T VL C TG P P I W ++S
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQ 462
Query: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDT 2223
R NG L I KL D+G Y C+A PSG+ T
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Score = 152 bits (384), Expect = 4e-36
Identities = 125/503 (24%), Positives = 203/503 (40%), Gaps = 39/503 (7%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + A L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 29 PRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G H V+ + ++ V G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
++C+ G P PT++W + + + + G L++ D G Y CV
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G ++S + ++ V+ P + +R + T +S + C A+G P P+V W D
Sbjct: 203 GTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
G + S+ + + TL IR + + D G+Y C+A + G LT++
Sbjct: 261 G------ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIHVYP 1997
P + + V G + C ATG P+P I WR + Q + S V
Sbjct: 315 PHFVVKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS----LRLKPAKIDHKQYFRKQVLHG 2053
G L I +V D G Y+C N G + ++ + +P + + + V
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
F + C A+GSPVP I W DG +++ + R NG L + +
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQIRYAKLGD 483
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTV 2136
G YTC A G+ ++ V
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEV 506
Score = 139 bits (349), Expect = 5e-32
Identities = 136/499 (27%), Positives = 198/499 (39%), Gaps = 61/499 (12%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ A L+C+ G P P I W + + D H +GSL ++
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWY-KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 2204 KLLDSGEYVCVARNPSGD--------DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
D G YVCVARN G+ + + + D P + V++ R
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPR-- 156
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
G P P + W + RIT+ + G L I R SD+ ++CV
Sbjct: 157 ---------GHPEPTISWKKDGS---PLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 203
Query: 2316 RNEGGESVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N GE V +L VLE RP+F + P N + + S C G+P P + W
Sbjct: 204 TNMVGERESEVAELTVLE---RPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVIL--EIGQK 2431
+G P+S +Y I + + I K T D G Y C A N VG E L ++G +
Sbjct: 259 DDGEL----PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG----YVVDRPQINGKYILHD 2487
P P G +++ C + G P+P I W + PQ + ++ +
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTG 2543
G L I D G YIC+ N G + + V +I PP + + P +
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2544 AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
F L CVA G P P I W D L+ST +QL G L I+ + D+G Y
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR----IKQLE-NGVLQIRYAKLGDTGRY 487
Query: 2604 KCTAKNPLGSDYAATYIQV 2622
C A P G + YI+V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 70.5 bits (171), Expect = 2e-11
Identities = 49/175 (28%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYV--SEDGRILIDKSGKLELQMA 541
+ V +G TV C G+P P + W + Y R + ++G L +
Sbjct: 323 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVE----AYQENGIHHTVFIGETLDLPCHS 597
D G Y C + N + I + V + + + ++ ++ TV + T L C +
Sbjct: 383 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 442
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P +I W G V Q SR K+ L NG L+I D G Y C+A+ PSG
Sbjct: 443 TGSPVPTILWRKDGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 62.0 bits (149), Expect = 7e-09
Identities = 49/176 (27%), Positives = 73/176 (41%), Gaps = 20/176 (11%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V + C +GDP P V W DG ++ Y D L+++ + D
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH-------TLKIRKVTAGDM 286
Query: 547 GVYHCISSNY----DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
G Y C++ N + + LT ++ P + + V +G T+ C +TG P
Sbjct: 287 GSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV---VALGRTVTFQCEATGNPQ 343
Query: 603 ASISWVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W G+ N+L+ QSS V G L I V D GYY C N +G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 399
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 11/170 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W G +V ++ SG L
Sbjct: 43 GEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D GVY C++ NY + V L + +++N V +GE + C G P+
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 604 SISWVIPGNNVLYQSSRDKKV-LNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ISW G+ + +D+++ + G L I D G Y CV N G
Sbjct: 162 TISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ TV V GT L+C G P P + W DG V ++D RI ++G L+++ A
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVS----TQDSRIKQLENGVLQIRYAK 480
Query: 543 SFDTGVYHCISS 554
DTG Y CI+S
Sbjct: 481 LGDTGRYTCIAS 492
Score = 41.6 bits (96), Expect = 0.010
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 8/92 (8%)
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
+PPRI P IV++ G L+C A G P P I W + + R+H L
Sbjct: 27 FPPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH--RMLL 83
Query: 2586 LQGTL-----VIQNPQTSDSGIYKCTAKNPLG 2612
G+L V D G+Y C A+N LG
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 172 bits (436), Expect = 4e-42
Identities = 172/686 (25%), Positives = 277/686 (40%), Gaps = 88/686 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
PP I+E +IV GE L C A+G P P++ W S L +G
Sbjct: 28 PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 1901 TLYIRNLASS-----DRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQK 1949
+L+ + D G Y C+A + G + V +L + R + A
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA--- 143
Query: 1950 RTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
G+ ++ C G P+P I W+ + D+ R+ G L I +
Sbjct: 144 -----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI-----TIRGGKLMITYTRK 193
Query: 2009 KDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
D+G Y+CV N +G+ + + +++ +P+ + V +F+ C+A G PV
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK--CEARGDPV 251
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P + W DG + + RY + ++ TL KV + G YTC A+N +GK
Sbjct: 252 PTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2128 DEMKVHLTV-ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
E LTV + + P ++ + G T CE TG+P+P IFW + + FS
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 359
Query: 2187 I------DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD-DTKMY--KLDVVS--KPP 2235
R++ G LTI V+ D G Y+C N +G TK Y DV++ PP
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Query: 2236 LINGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK 2294
+I N+TV + T V C A G+P P ++W D + ++ SRI +
Sbjct: 420 VIRQGPVNQTVAVDGTFV------LSCVATGSPVPTILW-RKDGVLVST--QDSRIKQLE 470
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
NG L+IR +L D+ + C+A GE+ +EV E + Q +
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF------------GVPVQPPRP 518
Query: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAAR 2414
T N PE+ + N S P A+ S+II + ++ A
Sbjct: 519 TDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG--ATPTSYIIEAFSHASGSSWQTVAE 576
Query: 2415 NKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVV 2474
N + L+ + L A GIS S +SD + ++ +P+ V
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRA-ANAYGISDPSQ----ISDPVKTQDV---LPTSQGV 628
Query: 2475 DRPQIN---GKYILHDNGTLVIKEAT 2497
D Q+ G +LH + V+ ++
Sbjct: 629 DHKQVQRELGNAVLHLHNPTVLSSSS 654
Score = 163 bits (412), Expect = 2e-39
Identities = 147/517 (28%), Positives = 216/517 (41%), Gaps = 48/517 (9%)
Query: 1722 LCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL 1781
LCS S L D +PPRI+E + ++ V G L C+AEGRP+PT+ W
Sbjct: 16 LCSGSRLRQED----------FPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Query: 1782 ANQTVVSESSQGSRQAVVTVDGTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKI 1835
+ V ++ ++ G+L ++H S D G Y CVA N G+ S +
Sbjct: 65 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL 124
Query: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+V + V+V GE + C +G P+P++ W DG+ PL + ++
Sbjct: 125 EVAILRDDFRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISW-KKDGS---PLDDKDERI 179
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGS-ERRVVMLTMEERVTSPRIEAASQKRTEV 1953
+ G L I SD G Y C+ T+ G E V LT+ ER + + V
Sbjct: 180 TI-RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK----RPSNLAV 234
Query: 1954 NFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV 2013
D C A G+P P + WR D S + + +L I VT D G
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWR------KDDGELPKSRYEIRDDHTLKIRKVTAGDMGS 288
Query: 2014 YLCVARNKMG--DDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPEI 2070
Y CVA N +G + + V + +P K R QV+ G+ C+A+G+P P I
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKP--RDQVVALGRTVTFQCEATGNPQPAI 346
Query: 2071 SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEM 2130
W + + Q S + R+++ G L V ++ G Y C N G
Sbjct: 347 FWRREGSQNLLFSYQPPQS---SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403
Query: 2131 KVHLTVITA----APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
K +L V P + + N+ + T VL C TG P P I W ++S
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQ 462
Query: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDT 2223
R NG L I KL D+G Y C+A PSG+ T
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Score = 152 bits (384), Expect = 4e-36
Identities = 125/503 (24%), Positives = 203/503 (40%), Gaps = 39/503 (7%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + A L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 29 PRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G H V+ + ++ V G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
++C+ G P PT++W + + + + G L++ D G Y CV
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G ++S + ++ V+ P + +R + T +S + C A+G P P+V W D
Sbjct: 203 GTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
G + S+ + + TL IR + + D G+Y C+A + G LT++
Sbjct: 261 G------ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
Query: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIHVYP 1997
P + + V G + C ATG P+P I WR + Q + S V
Sbjct: 315 PHFVVKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 1998 NGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS----LRLKPAKIDHKQYFRKQVLHG 2053
G L I +V D G Y+C N G + ++ + +P + + + V
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
F + C A+GSPVP I W DG +++ + R NG L + +
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQIRYAKLGD 483
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTV 2136
G YTC A G+ ++ V
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEV 506
Score = 139 bits (349), Expect = 5e-32
Identities = 136/499 (27%), Positives = 198/499 (39%), Gaps = 61/499 (12%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ A L+C+ G P P I W + + D H +GSL ++
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWY-KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 2204 KLLDSGEYVCVARNPSGD--------DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
D G YVCVARN G+ + + + D P + V++ R
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPR-- 156
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
G P P + W + RIT+ + G L I R SD+ ++CV
Sbjct: 157 ---------GHPEPTISWKKDGS---PLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 203
Query: 2316 RNEGGESVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N GE V +L VLE RP+F + P N + + S C G+P P + W
Sbjct: 204 TNMVGERESEVAELTVLE---RPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVIL--EIGQK 2431
+G P+S +Y I + + I K T D G Y C A N VG E L ++G +
Sbjct: 259 DDGEL----PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG----YVVDRPQINGKYILHD 2487
P P G +++ C + G P+P I W + PQ + ++ +
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTG 2543
G L I D G YIC+ N G + + V +I PP + + P +
Sbjct: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 2544 AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
F L CVA G P P I W D L+ST +QL G L I+ + D+G Y
Sbjct: 434 GTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR----IKQLE-NGVLQIRYAKLGDTGRY 487
Query: 2604 KCTAKNPLGSDYAATYIQV 2622
C A P G + YI+V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 70.5 bits (171), Expect = 2e-11
Identities = 49/175 (28%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYV--SEDGRILIDKSGKLELQMA 541
+ V +G TV C G+P P + W + Y R + ++G L +
Sbjct: 323 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVE----AYQENGIHHTVFIGETLDLPCHS 597
D G Y C + N + I + V + + + ++ ++ TV + T L C +
Sbjct: 383 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 442
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P +I W G V Q SR K+ L NG L+I D G Y C+A+ PSG
Sbjct: 443 TGSPVPTILWRKDGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 62.0 bits (149), Expect = 7e-09
Identities = 49/176 (27%), Positives = 73/176 (41%), Gaps = 20/176 (11%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V + C +GDP P V W DG ++ Y D L+++ + D
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH-------TLKIRKVTAGDM 286
Query: 547 GVYHCISSNY----DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
G Y C++ N + + LT ++ P + + V +G T+ C +TG P
Sbjct: 287 GSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV---VALGRTVTFQCEATGNPQ 343
Query: 603 ASISWVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W G+ N+L+ QSS V G L I V D GYY C N +G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 399
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 11/170 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W G +V ++ SG L
Sbjct: 43 GEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D GVY C++ NY + V L + +++N V +GE + C G P+
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 604 SISWVIPGNNVLYQSSRDKKV-LNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ISW G+ + +D+++ + G L I D G Y CV N G
Sbjct: 162 TISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ TV V GT L+C G P P + W DG V ++D RI ++G L+++ A
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVS----TQDSRIKQLENGVLQIRYAK 480
Query: 543 SFDTGVYHCISS 554
DTG Y CI+S
Sbjct: 481 LGDTGRYTCIAS 492
Score = 41.6 bits (96), Expect = 0.010
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 8/92 (8%)
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
+PPRI P IV++ G L+C A G P P I W + + R+H L
Sbjct: 27 FPPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH--RMLL 83
Query: 2586 LQGTL-----VIQNPQTSDSGIYKCTAKNPLG 2612
G+L V D G+Y C A+N LG
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 172 bits (436), Expect = 4e-42
Identities = 139/518 (26%), Positives = 226/518 (43%), Gaps = 66/518 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKP-LQFTNSKLFLFSN 1899
PP I+E VIV GE L C A+G P P++ W DG V+ S L +
Sbjct: 46 PPRIVEHPSDVIVSK-GEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPS 103
Query: 1900 GTLYIRNL-----ASSDRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQ 1948
G+L+ + + D G+Y C+A + G + V +L + R + A+
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA- 162
Query: 1949 KRTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007
G+ +L C G P+P I W+ + D++ R+ G L I +
Sbjct: 163 -------GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERIS-----IRGGKLMISNTR 210
Query: 2008 EKDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSP 2066
+ D+G+Y CV N +G+ D +++ +P + ++ + VL + + C+ G P
Sbjct: 211 KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQGDP 268
Query: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
P + W + DD+ RY + ++ TL K +EG Y C A+N +G
Sbjct: 269 QPTVRW------------KKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 316
Query: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
K E LTV AP ++ + G T CE G+P+P +FW + + F
Sbjct: 317 KMEASATLTV--RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 374
Query: 2187 ID------RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVS-----KPP 2235
R + G LTI ++ D+G Y+C A +G +L+V PP
Sbjct: 375 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 434
Query: 2236 LINGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK 2294
+I N+T+ + TA+ C+A G P P + W+ T P R T+ +
Sbjct: 435 IILQGPANQTLAVDGTAL------LKCKATGDPLPVISWLKEG---FTFPGRDPRATIQE 485
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLE 2332
GTL+I+N+R+SD+ + CVA + GE+ L+V E
Sbjct: 486 QGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 523
Score = 156 bits (395), Expect = 2e-37
Identities = 140/484 (28%), Positives = 208/484 (42%), Gaps = 46/484 (9%)
Query: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKV 2109
V G+ ++CKA G P P I W DG + + D R+ R L +G+L+F ++
Sbjct: 58 VSKGEPTTLNCKAEGRPTPTIEW-YKDGERV----ETDKDDPRSHRM-LLPSGSLFFLRI 111
Query: 2110 -----GVAEEGDYTCYAQNTLGKDEMK-VHLTVITAAPRIRQSNKTNKRIKAGDTAVLDC 2163
+EG Y C A+N LG+ + L V RQ N T+ + AG+ A+L+C
Sbjct: 112 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ-NPTDVVVAAGEPAILEC 170
Query: 2164 EVT-GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD- 2221
+ G P+P I+W I +R + G L I+ + D+G Y CV N G+
Sbjct: 171 QPPRGHPEPTIYWK-KDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGER 228
Query: 2222 DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFL 2281
D+ +L V +P + N+ V++ AV F C+ +G P P V W D
Sbjct: 229 DSDPAELTVFERPTFLRRPI-NQVVLEEEAVE-----FRCQVQGDPQPTVRWKKDD---- 278
Query: 2282 TAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRN 2341
A R + + TL I+ +D ++C+A N G+ L V P F
Sbjct: 279 -ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP---PQFVV 334
Query: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR--FSNGPQ--SYQYLIASNGSFI 2397
++IVAQ G++ C GNP P + W F N PQ + + ++ G
Sbjct: 335 RPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 393
Query: 2398 ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQ------KPVILTYAPGTVKGISGESLS 2451
I+ R DAG Y C A G I LE+ P+IL + G +L
Sbjct: 394 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL- 452
Query: 2452 LHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNS 2511
L C + G P P I W + G+ P + + + + GTL IK D G Y C A +S
Sbjct: 453 LKCKATGDPLPVISW-LKEGFTF--PGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSS 509
Query: 2512 VGHT 2515
G T
Sbjct: 510 SGET 513
Score = 155 bits (393), Expect = 4e-37
Identities = 135/518 (26%), Positives = 214/518 (41%), Gaps = 49/518 (9%)
Query: 1743 YPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVD 1802
+PPRI+E + ++ V G L C+AEGRP+PT+ W + V ++ ++
Sbjct: 45 FPPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 103
Query: 1803 GTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKIQVIAAPPVILEQRRQVIVGTW 1856
G+L ++H S D G Y CVA N G+ S ++V + V+V
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA- 162
Query: 1857 GESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTY 1915
GE L C +G P+P++YW D + + G L I N SD G Y
Sbjct: 163 GEPAILECQPPRGHPEPTIYW-KKDKVRID----DKEERISIRGGKLMISNTRKSDAGMY 217
Query: 1916 ECIATSSTGS-ERRVVMLTMEERVTSPR--IEAASQKRTEVNFGDKLLLNCSATGEPKPQ 1972
C+ T+ G + LT+ ER T R I + V F C G+P+P
Sbjct: 218 TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF------RCQVQGDPQPT 271
Query: 1973 IMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS 2032
+ W+ D + + +L I D G Y+C+A N++G ++
Sbjct: 272 VRWK------KDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 325
Query: 2033 LRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHR 2092
+R P + + + V G+ C+ G+P P + W +G+ N + +
Sbjct: 326 VRAPPQFVVRPR--DQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGS--QNLLFPNQPQQP 380
Query: 2093 TRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG----KDEMKVHLTVITAAPRIRQSNK 2148
R ++ G L + ++ G Y C A G K +++V + P I
Sbjct: 381 NSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 440
Query: 2149 TNKRIKAGDTAVLDCEVTGDPKPKIFWL-----LPSNDMISFSIDRYTFHANGSLTINKV 2203
N+ + TA+L C+ TGDP P I WL P D R T G+L I +
Sbjct: 441 ANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRD------PRATIQEQGTLQIKNL 494
Query: 2204 KLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLY 2241
++ D+G Y CVA + SG+ + LDV I+ Y
Sbjct: 495 RISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNY 532
Score = 153 bits (386), Expect = 2e-36
Identities = 134/518 (25%), Positives = 208/518 (40%), Gaps = 52/518 (10%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 47 PRIVE-HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G V+ + ++ V +G
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 165
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
L+C+ G P PT+ W + + + S + G L++ N D G Y CV
Sbjct: 166 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-----GKLMISNTRKSDAGMYTCV 220
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G +DS ++ V P + QV++ E+++ C +G PQP+V W D
Sbjct: 221 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE--EAVEFRCQVQGDPQPTVRWKKDD 278
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTME---ER 1937
+ + + TL I+ S+D GTY CIA + G LT+ +
Sbjct: 279 A------DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 332
Query: 1938 VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIH 1994
V PR + +Q RT + C G P+P + W+ + +Q + S
Sbjct: 333 VVRPRDQIVAQGRT-------VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 385
Query: 1995 VYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGK 2054
V P G L I ++ D+G Y+C A G IL L + D Q +
Sbjct: 386 VSPTGDLTITNIQRSDAGYYICQALTVAGS--ILAKAQLEVTDVLTDRPPPIILQGPANQ 443
Query: 2055 DFQVD------CKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
VD CKA+G P+P ISW L +G R R T+ GTL
Sbjct: 444 TLAVDGTALLKCKATGDPLPVISW-LKEGFTFPG---------RDPRATIQEQGTLQIKN 493
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQS 2146
+ +++ G YTC A ++ G+ L V + I ++
Sbjct: 494 LRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKN 531
Score = 147 bits (371), Expect = 1e-34
Identities = 133/492 (27%), Positives = 201/492 (40%), Gaps = 44/492 (8%)
Query: 1953 VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI-----GSVT 2007
V+ G+ LNC A G P P I W + V + S + P+GSLF G +
Sbjct: 58 VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRS 117
Query: 2008 EKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKAS-GS 2065
+ D G Y+CVARN +G+ + + SL + + D +Q V+ G+ ++C+ G
Sbjct: 118 KPDEGSYVCVARNYLGE-AVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGH 176
Query: 2066 PVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTL 2125
P P I W + ++ DD R G L + ++ G YTC N +
Sbjct: 177 PEPTIYWK-------KDKVRIDDKEERIS----IRGGKLMISNTRKSDAGMYTCVGTNMV 225
Query: 2126 G-KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMIS 2184
G +D LTV +R+ N+ + + C+V GDP+P + W D
Sbjct: 226 GERDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRW---KKDDAD 280
Query: 2185 FSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNR 2244
RY + +L I K D G Y+C+A N G L V PP ++
Sbjct: 281 LPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL-TVRAPPQFVVRPRDQ 339
Query: 2245 TVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY----GSRITVHKNGTLEI 2300
V + V F C +G P P V W + L P SR +V G L I
Sbjct: 340 IVAQGRTVT-----FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 394
Query: 2301 RNVRLSDSADFICVARNEGGESVLVVQLEVLEMLR-RP---TFRNPFNEKIVAQLGKSTA 2356
N++ SD+ +IC A G + QLEV ++L RP + P N+ + + +
Sbjct: 395 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA--VDGTAL 452
Query: 2357 LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNK 2416
L C G+P P I W+ T P++ I G+ I D G Y C A +
Sbjct: 453 LKCKATGDPLPVISWLKEGFTFPGRDPRA---TIQEQGTLQIKNLRISDTGTYTCVATSS 509
Query: 2417 VGYIEKLVILEI 2428
G +L++
Sbjct: 510 SGETSWSAVLDV 521
Score = 124 bits (312), Expect = 9e-28
Identities = 130/486 (26%), Positives = 196/486 (40%), Gaps = 58/486 (11%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ L+C+ G P P I W + + D H +GSL ++
Sbjct: 58 VSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRR 116
Query: 2204 KLLDSGEYVCVARNPSGDD-TKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCR 2262
D G YVCVARN G+ ++ L+V L + N T + A + +C+
Sbjct: 117 SKPDEGSYVCVARNYLGEAVSRNASLEVAL---LRDDFRQNPTDVVVAAGEPAI--LECQ 171
Query: 2263 A-EGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGE 2321
G P P + W D + + RI++ + G L I N R SD+ + CV N GE
Sbjct: 172 PPRGHPEPTIYW-KKDKVRIDDKE--ERISI-RGGKLMISNTRKSDAGMYTCVGTNMVGE 227
Query: 2322 SVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWI-----LP 2374
+L V E RPTF R P N+ ++ + ++ C V G+P P + W LP
Sbjct: 228 RDSDPAELTVFE---RPTFLRRPINQVVLEE--EAVEFRCQVQGDPQPTVRWKKDDADLP 282
Query: 2375 NGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVI 2434
G +Y I + + I KT D G Y C A N+VG +E L + P
Sbjct: 283 RG----------RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 332
Query: 2435 LTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRP----QINGKYILHDNGT 2490
+ + G +++ C + G P+P + W + P Q N + + G
Sbjct: 333 VVRPRDQIVA-QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 391
Query: 2491 LVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTGAAF 2546
L I D G YIC+A G L + V ++ PP I + P +
Sbjct: 392 LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 451
Query: 2547 QLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCT 2606
L C A G P P I+W + + + QGTL I+N + SD+G Y C
Sbjct: 452 LLKCKATGDPLPVISWLKEGFTFPGRDPRAT------IQEQGTLQIKNLRISDTGTYTCV 505
Query: 2607 AKNPLG 2612
A + G
Sbjct: 506 ATSSSG 511
Score = 120 bits (301), Expect = 2e-26
Identities = 106/382 (27%), Positives = 163/382 (42%), Gaps = 43/382 (11%)
Query: 2260 DCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT--------------LEIRNVRL 2305
+C+AEG P+P + W G R+ K+ L I + R
Sbjct: 67 NCKAEGRPTPTIEWYKD----------GERVETDKDDPRSHRMLLPSGSLFFLRIVHGRR 116
Query: 2306 S--DSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVD- 2362
S D ++CVARN GE+V + +LR +NP + +V G+ L C
Sbjct: 117 SKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD--VVVAAGEPAILECQPPR 174
Query: 2363 GNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEK 2422
G+P P I W + R + + + G +IS T + DAG Y C N VG +
Sbjct: 175 GHPEPTIYW-KKDKVRIDDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 230
Query: 2423 -LVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQING 2481
L + ++P L V + E++ C G P+P ++W D P+ G
Sbjct: 231 DPAELTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQPTVRWKKDDA---DLPR--G 284
Query: 2482 KYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTR 2541
+Y + D+ TL IK+ + D G Y+C A+N VG + + + A PP+ RP IV +
Sbjct: 285 RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA-PPQFVVRPRDQIVAQ 343
Query: 2542 TGAAFQLHCVALGVPKPEITWEMP-DHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDS 2600
G C G P+P + W+ +LL ++ + + G L I N Q SD+
Sbjct: 344 -GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA 402
Query: 2601 GIYKCTAKNPLGSDYAATYIQV 2622
G Y C A GS A ++V
Sbjct: 403 GYYICQALTVAGSILAKAQLEV 424
Score = 92.4 bits (228), Expect = 5e-18
Identities = 76/285 (26%), Positives = 114/285 (40%), Gaps = 23/285 (8%)
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRF---SNGPQSYQYLIASNGSFII----S 2399
++ G+ T LNC +G P P I W +G R + P+S++ L+ S F +
Sbjct: 56 VIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHG 114
Query: 2400 KTTREDAGKYRCAARNKVG-YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSD- 2457
+ ++ D G Y C ARN +G + + LE+ P V +GE L C
Sbjct: 115 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPR 174
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
G P+P I W + D+ + I G L+I D G Y C N VG
Sbjct: 175 GHPEPTIYWKKDKVRIDDKEE----RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 230
Query: 2518 TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKER 2577
+ V P RP +V A + C G P+P + W+ D L
Sbjct: 231 DPAELTVFERPTFLRRPINQVVLEE-EAVEFRCQVQGDPQPTVRWKKDDADL-------- 281
Query: 2578 THGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G + TL I+ ++D G Y C A+N +G A+ + V
Sbjct: 282 PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 326
Score = 58.9 bits (141), Expect = 6e-08
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 14/181 (7%)
Query: 2439 PGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYV-VDRPQINGKYILHDNGTL-----V 2492
P V GE +L+C ++G P P I+W V D+ +L +G+L V
Sbjct: 53 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 112
Query: 2493 IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHC-V 2551
+ D G+Y+C A+N +G + + VA + P +V G L C
Sbjct: 113 HGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQP 172
Query: 2552 ALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPL 2611
G P+P I W+ + + G G L+I N + SD+G+Y C N +
Sbjct: 173 PRGHPEPTIYWKKDKVRIDDKEERISIRG-------GKLMISNTRKSDAGMYTCVGTNMV 225
Query: 2612 G 2612
G
Sbjct: 226 G 226
Score = 57.4 bits (137), Expect = 2e-07
Identities = 50/176 (28%), Positives = 67/176 (38%), Gaps = 15/176 (8%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ VL V C QGDP P V W D R GR I L ++
Sbjct: 248 INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-------GRYDIKDDYTLRIKKTM 300
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
S D G Y CI+ N + +TV P + V G T+ PC + G P
Sbjct: 301 STDEGTYMCIAENRVGKMEASATLTVRAP--PQFVVRPRDQIVAQGRTVTFPCETKGNPQ 358
Query: 603 ASISWVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
++ W G+ N+L+ Q + V G L I + D GYY C A +G
Sbjct: 359 PAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 414
Score = 54.3 bits (129), Expect = 2e-06
Identities = 44/175 (25%), Positives = 71/175 (40%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSE--DGRILIDKSGKLELQMA 541
+ V G TV C +G+P P V W + P + + R + +G L +
Sbjct: 338 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 397
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVEA----YQENGIHHTVFIGETLDLPCHS 597
D G Y C + + + ++ V + L + + + T+ + T L C +
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 457
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P ISW+ G + R + GTL+I + D G Y CVA + SG
Sbjct: 458 TGDPLPVISWLKEGFTFPGRDPR-ATIQEQGTLQIKNLRISDTGTYTCVATSSSG 511
Score = 53.1 bits (126), Expect = 3e-06
Identities = 44/169 (26%), Positives = 63/169 (37%), Gaps = 9/169 (5%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W DG +V ++ SG L
Sbjct: 61 GEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP 119
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D G Y C++ NY + V L + +++N V GE L C G P+
Sbjct: 120 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEP 179
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W + V ++ + G L I D G Y CV N G
Sbjct: 180 TIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 226
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 172 bits (436), Expect = 4e-42
Identities = 139/518 (26%), Positives = 226/518 (43%), Gaps = 66/518 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKP-LQFTNSKLFLFSN 1899
PP I+E VIV GE L C A+G P P++ W DG V+ S L +
Sbjct: 30 PPRIVEHPSDVIVSK-GEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPS 87
Query: 1900 GTLYIRNL-----ASSDRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQ 1948
G+L+ + + D G+Y C+A + G + V +L + R + A+
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA- 146
Query: 1949 KRTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007
G+ +L C G P+P I W+ + D++ R+ G L I +
Sbjct: 147 -------GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERIS-----IRGGKLMISNTR 194
Query: 2008 EKDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSP 2066
+ D+G+Y CV N +G+ D +++ +P + ++ + VL + + C+ G P
Sbjct: 195 KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQGDP 252
Query: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
P + W + DD+ RY + ++ TL K +EG Y C A+N +G
Sbjct: 253 QPTVRW------------KKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
Query: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
K E LTV AP ++ + G T CE G+P+P +FW + + F
Sbjct: 301 KMEASATLTV--RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 358
Query: 2187 ID------RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVS-----KPP 2235
R + G LTI ++ D+G Y+C A +G +L+V PP
Sbjct: 359 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 418
Query: 2236 LINGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK 2294
+I N+T+ + TA+ C+A G P P + W+ T P R T+ +
Sbjct: 419 IILQGPANQTLAVDGTAL------LKCKATGDPLPVISWLKEG---FTFPGRDPRATIQE 469
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLE 2332
GTL+I+N+R+SD+ + CVA + GE+ L+V E
Sbjct: 470 QGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 507
Score = 156 bits (395), Expect = 2e-37
Identities = 140/484 (28%), Positives = 208/484 (42%), Gaps = 46/484 (9%)
Query: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKV 2109
V G+ ++CKA G P P I W DG + + D R+ R L +G+L+F ++
Sbjct: 42 VSKGEPTTLNCKAEGRPTPTIEW-YKDGERV----ETDKDDPRSHRM-LLPSGSLFFLRI 95
Query: 2110 -----GVAEEGDYTCYAQNTLGKDEMK-VHLTVITAAPRIRQSNKTNKRIKAGDTAVLDC 2163
+EG Y C A+N LG+ + L V RQ N T+ + AG+ A+L+C
Sbjct: 96 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ-NPTDVVVAAGEPAILEC 154
Query: 2164 EVT-GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD- 2221
+ G P+P I+W I +R + G L I+ + D+G Y CV N G+
Sbjct: 155 QPPRGHPEPTIYWK-KDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGER 212
Query: 2222 DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFL 2281
D+ +L V +P + N+ V++ AV F C+ +G P P V W D
Sbjct: 213 DSDPAELTVFERPTFLRRPI-NQVVLEEEAVE-----FRCQVQGDPQPTVRWKKDD---- 262
Query: 2282 TAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRN 2341
A R + + TL I+ +D ++C+A N G+ L V P F
Sbjct: 263 -ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP---PQFVV 318
Query: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR--FSNGPQ--SYQYLIASNGSFI 2397
++IVAQ G++ C GNP P + W F N PQ + + ++ G
Sbjct: 319 RPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
Query: 2398 ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQ------KPVILTYAPGTVKGISGESLS 2451
I+ R DAG Y C A G I LE+ P+IL + G +L
Sbjct: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL- 436
Query: 2452 LHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNS 2511
L C + G P P I W + G+ P + + + + GTL IK D G Y C A +S
Sbjct: 437 LKCKATGDPLPVISW-LKEGFTF--PGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSS 493
Query: 2512 VGHT 2515
G T
Sbjct: 494 SGET 497
Score = 155 bits (393), Expect = 4e-37
Identities = 135/518 (26%), Positives = 214/518 (41%), Gaps = 49/518 (9%)
Query: 1743 YPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVD 1802
+PPRI+E + ++ V G L C+AEGRP+PT+ W + V ++ ++
Sbjct: 29 FPPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
Query: 1803 GTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKIQVIAAPPVILEQRRQVIVGTW 1856
G+L ++H S D G Y CVA N G+ S ++V + V+V
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA- 146
Query: 1857 GESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTY 1915
GE L C +G P+P++YW D + + G L I N SD G Y
Sbjct: 147 GEPAILECQPPRGHPEPTIYW-KKDKVRID----DKEERISIRGGKLMISNTRKSDAGMY 201
Query: 1916 ECIATSSTGS-ERRVVMLTMEERVTSPR--IEAASQKRTEVNFGDKLLLNCSATGEPKPQ 1972
C+ T+ G + LT+ ER T R I + V F C G+P+P
Sbjct: 202 TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF------RCQVQGDPQPT 255
Query: 1973 IMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS 2032
+ W+ D + + +L I D G Y+C+A N++G ++
Sbjct: 256 VRWK------KDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 309
Query: 2033 LRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHR 2092
+R P + + + V G+ C+ G+P P + W +G+ N + +
Sbjct: 310 VRAPPQFVVRPR--DQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGS--QNLLFPNQPQQP 364
Query: 2093 TRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG----KDEMKVHLTVITAAPRIRQSNK 2148
R ++ G L + ++ G Y C A G K +++V + P I
Sbjct: 365 NSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 424
Query: 2149 TNKRIKAGDTAVLDCEVTGDPKPKIFWL-----LPSNDMISFSIDRYTFHANGSLTINKV 2203
N+ + TA+L C+ TGDP P I WL P D R T G+L I +
Sbjct: 425 ANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRD------PRATIQEQGTLQIKNL 478
Query: 2204 KLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLY 2241
++ D+G Y CVA + SG+ + LDV I+ Y
Sbjct: 479 RISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNY 516
Score = 153 bits (386), Expect = 2e-36
Identities = 134/518 (25%), Positives = 208/518 (40%), Gaps = 52/518 (10%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 31 PRIVE-HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G V+ + ++ V +G
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
L+C+ G P PT+ W + + + S + G L++ N D G Y CV
Sbjct: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-----GKLMISNTRKSDAGMYTCV 204
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G +DS ++ V P + QV++ E+++ C +G PQP+V W D
Sbjct: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE--EAVEFRCQVQGDPQPTVRWKKDD 262
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTME---ER 1937
+ + + TL I+ S+D GTY CIA + G LT+ +
Sbjct: 263 A------DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 316
Query: 1938 VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIH 1994
V PR + +Q RT + C G P+P + W+ + +Q + S
Sbjct: 317 VVRPRDQIVAQGRT-------VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 369
Query: 1995 VYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGK 2054
V P G L I ++ D+G Y+C A G IL L + D Q +
Sbjct: 370 VSPTGDLTITNIQRSDAGYYICQALTVAGS--ILAKAQLEVTDVLTDRPPPIILQGPANQ 427
Query: 2055 DFQVD------CKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
VD CKA+G P+P ISW L +G R R T+ GTL
Sbjct: 428 TLAVDGTALLKCKATGDPLPVISW-LKEGFTFPG---------RDPRATIQEQGTLQIKN 477
Query: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQS 2146
+ +++ G YTC A ++ G+ L V + I ++
Sbjct: 478 LRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKN 515
Score = 147 bits (371), Expect = 1e-34
Identities = 133/492 (27%), Positives = 201/492 (40%), Gaps = 44/492 (8%)
Query: 1953 VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI-----GSVT 2007
V+ G+ LNC A G P P I W + V + S + P+GSLF G +
Sbjct: 42 VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRS 101
Query: 2008 EKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKAS-GS 2065
+ D G Y+CVARN +G+ + + SL + + D +Q V+ G+ ++C+ G
Sbjct: 102 KPDEGSYVCVARNYLGE-AVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGH 160
Query: 2066 PVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTL 2125
P P I W + ++ DD R G L + ++ G YTC N +
Sbjct: 161 PEPTIYWK-------KDKVRIDDKEERIS----IRGGKLMISNTRKSDAGMYTCVGTNMV 209
Query: 2126 G-KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMIS 2184
G +D LTV +R+ N+ + + C+V GDP+P + W D
Sbjct: 210 GERDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRW---KKDDAD 264
Query: 2185 FSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNR 2244
RY + +L I K D G Y+C+A N G L V PP ++
Sbjct: 265 LPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL-TVRAPPQFVVRPRDQ 323
Query: 2245 TVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY----GSRITVHKNGTLEI 2300
V + V F C +G P P V W + L P SR +V G L I
Sbjct: 324 IVAQGRTVT-----FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
Query: 2301 RNVRLSDSADFICVARNEGGESVLVVQLEVLEMLR-RP---TFRNPFNEKIVAQLGKSTA 2356
N++ SD+ +IC A G + QLEV ++L RP + P N+ + + +
Sbjct: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA--VDGTAL 436
Query: 2357 LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNK 2416
L C G+P P I W+ T P++ I G+ I D G Y C A +
Sbjct: 437 LKCKATGDPLPVISWLKEGFTFPGRDPRA---TIQEQGTLQIKNLRISDTGTYTCVATSS 493
Query: 2417 VGYIEKLVILEI 2428
G +L++
Sbjct: 494 SGETSWSAVLDV 505
Score = 124 bits (312), Expect = 9e-28
Identities = 130/486 (26%), Positives = 196/486 (40%), Gaps = 58/486 (11%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ L+C+ G P P I W + + D H +GSL ++
Sbjct: 42 VSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRR 100
Query: 2204 KLLDSGEYVCVARNPSGDD-TKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCR 2262
D G YVCVARN G+ ++ L+V L + N T + A + +C+
Sbjct: 101 SKPDEGSYVCVARNYLGEAVSRNASLEVAL---LRDDFRQNPTDVVVAAGEPAI--LECQ 155
Query: 2263 A-EGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGE 2321
G P P + W D + + RI++ + G L I N R SD+ + CV N GE
Sbjct: 156 PPRGHPEPTIYW-KKDKVRIDDKE--ERISI-RGGKLMISNTRKSDAGMYTCVGTNMVGE 211
Query: 2322 SVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWI-----LP 2374
+L V E RPTF R P N+ ++ + ++ C V G+P P + W LP
Sbjct: 212 RDSDPAELTVFE---RPTFLRRPINQVVLEE--EAVEFRCQVQGDPQPTVRWKKDDADLP 266
Query: 2375 NGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVI 2434
G +Y I + + I KT D G Y C A N+VG +E L + P
Sbjct: 267 RG----------RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 316
Query: 2435 LTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRP----QINGKYILHDNGT 2490
+ + G +++ C + G P+P + W + P Q N + + G
Sbjct: 317 VVRPRDQIVA-QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 375
Query: 2491 LVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTGAAF 2546
L I D G YIC+A G L + V ++ PP I + P +
Sbjct: 376 LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 435
Query: 2547 QLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCT 2606
L C A G P P I+W + + + QGTL I+N + SD+G Y C
Sbjct: 436 LLKCKATGDPLPVISWLKEGFTFPGRDPRAT------IQEQGTLQIKNLRISDTGTYTCV 489
Query: 2607 AKNPLG 2612
A + G
Sbjct: 490 ATSSSG 495
Score = 120 bits (301), Expect = 2e-26
Identities = 106/382 (27%), Positives = 163/382 (42%), Gaps = 43/382 (11%)
Query: 2260 DCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT--------------LEIRNVRL 2305
+C+AEG P+P + W G R+ K+ L I + R
Sbjct: 51 NCKAEGRPTPTIEWYKD----------GERVETDKDDPRSHRMLLPSGSLFFLRIVHGRR 100
Query: 2306 S--DSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVD- 2362
S D ++CVARN GE+V + +LR +NP + +V G+ L C
Sbjct: 101 SKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD--VVVAAGEPAILECQPPR 158
Query: 2363 GNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEK 2422
G+P P I W + R + + + G +IS T + DAG Y C N VG +
Sbjct: 159 GHPEPTIYW-KKDKVRIDDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
Query: 2423 -LVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQING 2481
L + ++P L V + E++ C G P+P ++W D P+ G
Sbjct: 215 DPAELTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQPTVRWKKDDA---DLPR--G 268
Query: 2482 KYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTR 2541
+Y + D+ TL IK+ + D G Y+C A+N VG + + + A PP+ RP IV +
Sbjct: 269 RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA-PPQFVVRPRDQIVAQ 327
Query: 2542 TGAAFQLHCVALGVPKPEITWEMP-DHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDS 2600
G C G P+P + W+ +LL ++ + + G L I N Q SD+
Sbjct: 328 -GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA 386
Query: 2601 GIYKCTAKNPLGSDYAATYIQV 2622
G Y C A GS A ++V
Sbjct: 387 GYYICQALTVAGSILAKAQLEV 408
Score = 92.4 bits (228), Expect = 5e-18
Identities = 76/285 (26%), Positives = 114/285 (40%), Gaps = 23/285 (8%)
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRF---SNGPQSYQYLIASNGSFII----S 2399
++ G+ T LNC +G P P I W +G R + P+S++ L+ S F +
Sbjct: 40 VIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHG 98
Query: 2400 KTTREDAGKYRCAARNKVG-YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSD- 2457
+ ++ D G Y C ARN +G + + LE+ P V +GE L C
Sbjct: 99 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPR 158
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
G P+P I W + D+ + I G L+I D G Y C N VG
Sbjct: 159 GHPEPTIYWKKDKVRIDDKEE----RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
Query: 2518 TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKER 2577
+ V P RP +V A + C G P+P + W+ D L
Sbjct: 215 DPAELTVFERPTFLRRPINQVVLEE-EAVEFRCQVQGDPQPTVRWKKDDADL-------- 265
Query: 2578 THGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G + TL I+ ++D G Y C A+N +G A+ + V
Sbjct: 266 PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
Score = 58.9 bits (141), Expect = 6e-08
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 14/181 (7%)
Query: 2439 PGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYV-VDRPQINGKYILHDNGTL-----V 2492
P V GE +L+C ++G P P I+W V D+ +L +G+L V
Sbjct: 37 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 96
Query: 2493 IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHC-V 2551
+ D G+Y+C A+N +G + + VA + P +V G L C
Sbjct: 97 HGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQP 156
Query: 2552 ALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPL 2611
G P+P I W+ + + G G L+I N + SD+G+Y C N +
Sbjct: 157 PRGHPEPTIYWKKDKVRIDDKEERISIRG-------GKLMISNTRKSDAGMYTCVGTNMV 209
Query: 2612 G 2612
G
Sbjct: 210 G 210
Score = 57.4 bits (137), Expect = 2e-07
Identities = 50/176 (28%), Positives = 67/176 (38%), Gaps = 15/176 (8%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ VL V C QGDP P V W D R GR I L ++
Sbjct: 232 INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-------GRYDIKDDYTLRIKKTM 284
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
S D G Y CI+ N + +TV P + V G T+ PC + G P
Sbjct: 285 STDEGTYMCIAENRVGKMEASATLTVRAP--PQFVVRPRDQIVAQGRTVTFPCETKGNPQ 342
Query: 603 ASISWVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
++ W G+ N+L+ Q + V G L I + D GYY C A +G
Sbjct: 343 PAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 398
Score = 54.3 bits (129), Expect = 2e-06
Identities = 44/175 (25%), Positives = 71/175 (40%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSE--DGRILIDKSGKLELQMA 541
+ V G TV C +G+P P V W + P + + R + +G L +
Sbjct: 322 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 381
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVEA----YQENGIHHTVFIGETLDLPCHS 597
D G Y C + + + ++ V + L + + + T+ + T L C +
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P ISW+ G + R + GTL+I + D G Y CVA + SG
Sbjct: 442 TGDPLPVISWLKEGFTFPGRDPR-ATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
Score = 53.1 bits (126), Expect = 3e-06
Identities = 44/169 (26%), Positives = 63/169 (37%), Gaps = 9/169 (5%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W DG +V ++ SG L
Sbjct: 45 GEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP 103
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D G Y C++ NY + V L + +++N V GE L C G P+
Sbjct: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEP 163
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+I W + V ++ + G L I D G Y CV N G
Sbjct: 164 TIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 210
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 171 bits (433), Expect = 9e-42
Identities = 122/394 (30%), Positives = 191/394 (48%), Gaps = 28/394 (7%)
Query: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
E+PRI + + + + + C A GNP P I W R + L + K +SR+ +L +
Sbjct: 244 ERPRITS-EPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM---KTDSRLNLLDD 299
Query: 1706 GTLSIQRVEIQDRGQYLCSASNLFG-TDHLHVTLSVVSYPPR---ILERRTKEITVHSGS 1761
GTL IQ + D+G Y C A N+ G VTL P R +++ + E+ V G
Sbjct: 300 GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV--GE 357
Query: 1762 TVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
+V L+C A G P P ++W ++T + + + +T G L + N+ D G Y C
Sbjct: 358 SVTLECSATGHPPPRISWTRGDRTPLPVDPRVN----ITPSGGLYIQNVVQGDSGEYACS 413
Query: 1822 ASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
A+N I V A P + + +V++ G+++ C AKG P P + W G
Sbjct: 414 ATNNIDSVHATAFIIVQALPQFTVTPQDRVVIE--GQTVDFQCEAKGNPPPVIAWT-KGG 470
Query: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP 1941
+++ + + + S+GTL I +A D+G YEC A + GS++ V LT++ RVT
Sbjct: 471 SQLS----VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP- 525
Query: 1942 RIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSL 2001
+ A+ T V G + L CS+ GEP+P I W V + H+ P G L
Sbjct: 526 -VFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGK-----FHISPEGFL 579
Query: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRL 2035
I V D+G Y CVARN +G + M +S+ +
Sbjct: 580 TINDVGPADAGRYECVARNTIGSASVSMVLSVNV 613
Score = 162 bits (411), Expect = 3e-39
Identities = 113/378 (29%), Positives = 182/378 (48%), Gaps = 26/378 (6%)
Query: 1855 TWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGT 1914
T G ++ C A+G P+P + W L + E+ T+S+L L +GTL I+N +D+G
Sbjct: 258 TSGNTVYFTCRAEGNPKPEIIW-LRNNNELS--MKTDSRLNLLDDGTLMIQNTQETDQGI 314
Query: 1915 YECIATSSTGSERRVVMLTMEERVTSPRIEAASQ-KRTEVNFGDKLLLNCSATGEPKPQI 1973
Y+C+A + G E + +T+ + R Q + TEV G+ + L CSATG P P+I
Sbjct: 315 YQCMAKNVAG-EVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRI 373
Query: 1974 MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSL 2033
W + + RV ++ P+G L+I +V + DSG Y C A N + + +
Sbjct: 374 SWTRGDRTPLPVDPRV----NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV 429
Query: 2034 RLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRT 2093
+ P Q + V+ G+ C+A G+P P I+W T + + D
Sbjct: 430 QALPQFTVTPQ--DRVVIEGQTVDFQCEAKGNPPPVIAW-----TKGGSQLSVD------ 476
Query: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI 2153
RR+ + ++GTL + V + ++G Y C A N +G ++ HLTV + S ++ +
Sbjct: 477 RRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV 536
Query: 2154 KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS-IDRYTFHANGSLTINKVKLLDSGEYV 2212
+ G L C G+P+P I W + D + + ++ G LTIN V D+G Y
Sbjct: 537 EVGANVQLPCSSQGEPEPAITW---NKDGVQVTESGKFHISPEGFLTINDVGPADAGRYE 593
Query: 2213 CVARNPSGDDTKMYKLDV 2230
CVARN G + L V
Sbjct: 594 CVARNTIGSASVSMVLSV 611
Score = 155 bits (392), Expect = 5e-37
Identities = 102/367 (27%), Positives = 167/367 (45%), Gaps = 21/367 (5%)
Query: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317
+F CRAEG P PE++W+ +N SR+ + +GTL I+N + +D + C+A+N
Sbjct: 264 YFTCRAEGNPKPEIIWLRNNNELSMKT--DSRLNLLDDGTLMIQNTQETDQGIYQCMAKN 321
Query: 2318 EGGE-SVLVVQLEVLEMLRRPTFR-NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPN 2375
GE V L RPTF P N +++ +G+S L CS G+PPP I W +
Sbjct: 322 VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVL--VGESVTLECSATGHPPPRISWTRGD 379
Query: 2376 GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL 2435
T P+ I +G I + D+G+Y C+A N + + + + P
Sbjct: 380 RTPLPVDPRVN---ITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQF- 435
Query: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495
T P I G+++ C + G P P I WT + ++ ++++ +GTL I
Sbjct: 436 TVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL----SVDRRHLVLSSGTLRISG 491
Query: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGV 2555
+D+G Y C+A N +G + + + + P GA QL C + G
Sbjct: 492 VALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGE 551
Query: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
P+P ITW + + G + +G L I + +D+G Y+C A+N +GS
Sbjct: 552 PEPAITWNKDGVQVTES-------GKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
Query: 2616 AATYIQV 2622
+ + V
Sbjct: 605 VSMVLSV 611
Score = 139 bits (350), Expect = 4e-32
Identities = 112/400 (28%), Positives = 180/400 (45%), Gaps = 28/400 (7%)
Query: 2141 PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTI 2200
PRI S + + +G+T C G+PKP+I WL +N++ + R +G+L I
Sbjct: 246 PRIT-SEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMI 304
Query: 2201 NKVKLLDSGEYVCVARNPSGD-DTKMYKLDVVSKP--PLINGLYTNRTVIKATAVRHSKK 2257
+ D G Y C+A+N +G+ T+ L P P N V+ +V
Sbjct: 305 QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT---- 360
Query: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317
+C A G P P + W D L R+ + +G L I+NV DS ++ C A N
Sbjct: 361 -LECSATGHPPPRISWTRGDRTPLPV---DPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Query: 2318 EGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGT 2377
+SV +++ L P F +++V + G++ C GNPPP I W G+
Sbjct: 417 -NIDSVHATAFIIVQAL--PQFTVTPQDRVVIE-GQTVDFQCEAKGNPPPVIAW-TKGGS 471
Query: 2378 RFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQK--PVIL 2435
+ S ++L+ S+G+ IS D G+Y C A N +G + + L + + PV
Sbjct: 472 QLS---VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFA 528
Query: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495
+ T + G ++ L C S G P+P I W V + +GK+ + G L I +
Sbjct: 529 SIPSDTTVEV-GANVQLPCSSQGEPEPAITWNKDGVQVTE----SGKFHISPEGFLTIND 583
Query: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPP 2535
D G Y C A+N++G +++ V+ V P N P
Sbjct: 584 VGPADAGRYECVARNTIGSASVSM-VLSVNVPDVSRNGDP 622
Score = 128 bits (321), Expect = 8e-29
Identities = 109/389 (28%), Positives = 163/389 (41%), Gaps = 44/389 (11%)
Query: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKV 2109
V G C+A G+P PEI W + + +M+ D R L ++GTL
Sbjct: 257 VTSGNTVYFTCRAEGNPKPEIIWLRNNNEL---SMKTDS------RLNLLDDGTLMIQNT 307
Query: 2110 GVAEEGDYTCYAQNTLGK---DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT 2166
++G Y C A+N G+ E+ + A P N + G++ L+C T
Sbjct: 308 QETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF-VIQPQNTEVLVGESVTLECSAT 366
Query: 2167 GDPKPKIFWLLPSNDMISFSID-RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKM 2225
G P P+I W D +D R +G L I V DSGEY C A N + D
Sbjct: 367 GHPPPRISW--TRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN-NIDSVHA 423
Query: 2226 YKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPY 2285
+V P +R VI+ V F C A+G P P + W
Sbjct: 424 TAFIIVQALPQFTVTPQDRVVIEGQTV-----DFQCEAKGNPPPVIAWTKG--------- 469
Query: 2286 YGSRITVHK------NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF 2339
GS+++V + +GTL I V L D + C A N G +V L V + P F
Sbjct: 470 -GSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRV-TPVF 527
Query: 2340 RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIIS 2399
+ ++ V ++G + L CS G P P I W +G + + +S ++ I+ G I+
Sbjct: 528 ASIPSDTTV-EVGANVQLPCSSQGEPEPAITW-NKDGVQVT---ESGKFHISPEGFLTIN 582
Query: 2400 KTTREDAGKYRCAARNKVGYIEKLVILEI 2428
DAG+Y C ARN +G ++L +
Sbjct: 583 DVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 118 bits (295), Expect = 9e-26
Identities = 78/296 (26%), Positives = 130/296 (43%), Gaps = 48/296 (16%)
Query: 4 KGRGITCLLV-----SFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPN 58
+G G CLL ++ + +VA G CP RC C+ T V C L ++P ++ P
Sbjct: 6 RGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTT-VRCMHLLLEAVP-AVAPQ 63
Query: 59 VERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVR 118
++L +N + + F L L L+L++N I IP F DL+ L+ L + N+++
Sbjct: 64 TSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQ 123
Query: 119 KLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSY 178
+ + F GL SL +L++ N IE ++P+ F L L + L N++T L P TF
Sbjct: 124 SIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTF----- 178
Query: 179 LQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKP 238
+++ + L L N CDC + WL+D +
Sbjct: 179 ---------------------------NHLESMKRLRLDSNTLHCDCEILWLADLL---- 207
Query: 239 DVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLT 294
K +AQ +C PR +G+ +A ++ C +P I S + +T
Sbjct: 208 -----KTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVT 258
Score = 84.7 bits (208), Expect = 1e-15
Identities = 77/264 (29%), Positives = 118/264 (44%), Gaps = 25/264 (9%)
Query: 409 PKPEDIF--TNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMR 466
PKPE I+ N E ++ D + D +L + T T + Y A+ + +
Sbjct: 273 PKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGI---YQCMAKNVAGEVKTQ 329
Query: 467 PVKHKW-------TMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRA 519
V ++ T + + NT+ VLVG +V L C G P P + W D R
Sbjct: 330 EVTLRYFGSPARPTFVIQPQNTE----VLVGESVTLECSATGHPPPRISWTRGD----RT 381
Query: 520 PYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQEN 579
P + D R+ I SG L +Q D+G Y C ++N D+ T I +V+ L + +
Sbjct: 382 P-LPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFI-IVQALPQ-FTVT 438
Query: 580 GIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKD 639
V G+T+D C + G P I+W G+ + R VL++GTLRI V D
Sbjct: 439 PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL--SVDRRHLVLSSGTLRISGVALHD 496
Query: 640 QGYYRCVAANPSGVDFLIFQVSVK 663
QG Y C A N G ++ ++V+
Sbjct: 497 QGQYECQAVNIIGSQKVVAHLTVQ 520
Score = 73.6 bits (179), Expect = 2e-12
Identities = 55/184 (29%), Positives = 79/184 (42%), Gaps = 8/184 (4%)
Query: 481 TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM 540
T + V+ G TV C +G+P P + W GS++ S D R L+ SG L +
Sbjct: 438 TPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG-GSQL-----SVDRRHLVLSSGTLRISG 491
Query: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGI 600
D G Y C + N + + +TV + + TV +G + LPC S G
Sbjct: 492 VALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGE 551
Query: 601 PDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV 660
P+ +I+W G V S + G L I V P D G Y CVA N G + +
Sbjct: 552 PEPAITWNKDG--VQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVL 609
Query: 661 SVKM 664
SV +
Sbjct: 610 SVNV 613
Score = 63.5 bits (153), Expect = 3e-09
Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 9/166 (5%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V G TV C +G+P P + WL + + D R+ + G L +Q D
Sbjct: 257 VTSGNTVYFTCRAEGNPKPEIIWLRNNNEL----SMKTDSRLNLLDDGTLMIQNTQETDQ 312
Query: 547 GVYHCISSNYDDADILTYRITV---VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDA 603
G+Y C++ N ++ T +T+ P + + V +GE++ L C +TG P
Sbjct: 313 GIYQCMAKNV-AGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
Query: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
ISW L R + +G L I V D G Y C A N
Sbjct: 372 RISWTRGDRTPLPVDPR-VNITPSGGLYIQNVVQGDSGEYACSATN 416
Score = 57.8 bits (138), Expect = 1e-07
Identities = 41/110 (37%), Positives = 56/110 (50%), Gaps = 8/110 (7%)
Query: 2505 ICKAQNSV-GHTLITV-PVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITW 2562
IC+ + G ++ T+ P + PRIT+ P + VT +G C A G PKPEI W
Sbjct: 221 ICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVT-SGNTVYFTCRAEGNPKPEIIW 279
Query: 2563 EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
++ L +T L GTL+IQN Q +D GIY+C AKN G
Sbjct: 280 LRNNNEL-----SMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAG 324
Score = 44.3 bits (103), Expect = 0.002
Identities = 21/65 (32%), Positives = 33/65 (50%)
Query: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVA 647
G T+ C + G P I W+ N + ++ +L++GTL I DQG Y+C+A
Sbjct: 260 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
Query: 648 ANPSG 652
N +G
Sbjct: 320 KNVAG 324
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 171 bits (432), Expect = 1e-41
Identities = 172/685 (25%), Positives = 275/685 (40%), Gaps = 89/685 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
PP I+E +IV GE L C A+G P P++ W S L +G
Sbjct: 28 PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 1901 TLYIRNLASS-----DRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQK 1949
+L+ + D G Y C+A + G + V +L + R + A
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA--- 143
Query: 1950 RTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
G+ ++ C G P+P I W+ + D+ R+ G L I +
Sbjct: 144 -----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI-----TIRGGKLMITYTRK 193
Query: 2009 KDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
D+G Y+CV N +G+ + + +++ +P+ + V +F+ C+A G PV
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK--CEARGDPV 251
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P + W DG + + RY + ++ TL KV + G YTC A+N +GK
Sbjct: 252 PTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2128 DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSI 2187
E LTV P ++ + G T CE TG+P+P IFW + + FS
Sbjct: 300 AEASATLTV--QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
Query: 2188 ------DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD-DTKMY--KLDVVS--KPPL 2236
R++ G LTI V+ D G Y+C N +G TK Y DV++ PP+
Sbjct: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
Query: 2237 INGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKN 2295
I N+TV + T V C A G+P P ++W D + ++ SRI +N
Sbjct: 418 IRQGPVNQTVAVDGTFV------LSCVATGSPVPTILW-RKDGVLVST--QDSRIKQLEN 468
Query: 2296 GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKST 2355
G L+IR +L D+ + C+A GE+ +EV E + Q + T
Sbjct: 469 GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF------------GVPVQPPRPT 516
Query: 2356 ALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARN 2415
N PE+ + N S P A+ S+II + ++ A N
Sbjct: 517 DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG--ATPTSYIIEAFSHASGSSWQTVAEN 574
Query: 2416 KVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD 2475
+ L+ + L A GIS S +SD + ++ +P+ VD
Sbjct: 575 VKTETSAIKGLKPNAIYLFLVRA-ANAYGISDPSQ----ISDPVKTQDV---LPTSQGVD 626
Query: 2476 RPQIN---GKYILHDNGTLVIKEAT 2497
Q+ G +LH + V+ ++
Sbjct: 627 HKQVQRELGNAVLHLHNPTVLSSSS 651
Score = 162 bits (411), Expect = 3e-39
Identities = 145/515 (28%), Positives = 215/515 (41%), Gaps = 47/515 (9%)
Query: 1722 LCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL 1781
LCS S L D +PPRI+E + ++ V G L C+AEGRP+PT+ W
Sbjct: 16 LCSGSRLRQED----------FPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYK 64
Query: 1782 ANQTVVSESSQGSRQAVVTVDGTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKI 1835
+ V ++ ++ G+L ++H S D G Y CVA N G+ S +
Sbjct: 65 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL 124
Query: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+V + V+V GE + C +G P+P++ W DG+ PL + ++
Sbjct: 125 EVAILRDDFRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISW-KKDGS---PLDDKDERI 179
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGS-ERRVVMLTMEERVTSPRIEAASQKRTEV 1953
+ G L I SD G Y C+ T+ G E V LT+ ER + + V
Sbjct: 180 TI-RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK----RPSNLAV 234
Query: 1954 NFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV 2013
D C A G+P P + WR D S + + +L I VT D G
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWR------KDDGELPKSRYEIRDDHTLKIRKVTAGDMGS 288
Query: 2014 YLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPEISW 2072
Y CVA N +G ++++ P + R QV+ G+ C+A+G+P P I W
Sbjct: 289 YTCVAENMVGKAEASATLTVQEPPHFVVKP---RDQVVALGRTVTFQCEATGNPQPAIFW 345
Query: 2073 SLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKV 2132
+ + Q S + R+++ G L V ++ G Y C N G K
Sbjct: 346 RREGSQNLLFSYQPPQS---SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKA 402
Query: 2133 HLTVITA----APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSID 2188
+L V P + + N+ + T VL C TG P P I W ++S
Sbjct: 403 YLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQDS 461
Query: 2189 RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDT 2223
R NG L I KL D+G Y C+A PSG+ T
Sbjct: 462 RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 496
Score = 154 bits (388), Expect = 1e-36
Identities = 128/506 (25%), Positives = 206/506 (40%), Gaps = 48/506 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + A L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 29 PRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G H V+ + ++ V G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
++C+ G P PT++W + + + + G L++ D G Y CV
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G ++S + ++ V+ P + +R + T +S + C A+G P P+V W D
Sbjct: 203 GTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEER--- 1937
G + S+ + + TL IR + + D G+Y C+A + G LT++E
Sbjct: 261 G------ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 314
Query: 1938 VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIH 1994
V PR + + RT + C ATG P+P I WR + Q + S
Sbjct: 315 VVKPRDQVVALGRT-------VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 367
Query: 1995 VYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS----LRLKPAKIDHKQYFRKQV 2050
V G L I +V D G Y+C N G + ++ + +P + + + V
Sbjct: 368 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 427
Query: 2051 LHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVG 2110
F + C A+GSPVP I W DG +++ + R NG L
Sbjct: 428 AVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQIRYAK 477
Query: 2111 VAEEGDYTCYAQNTLGKDEMKVHLTV 2136
+ + G YTC A G+ ++ V
Sbjct: 478 LGDTGRYTCIASTPSGEATWSAYIEV 503
Score = 138 bits (347), Expect = 8e-32
Identities = 135/497 (27%), Positives = 198/497 (39%), Gaps = 60/497 (12%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ A L+C+ G P P I W + + D H +GSL ++
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWY-KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 2204 KLLDSGEYVCVARNPSGD--------DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
D G YVCVARN G+ + + + D P + V++ R
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPR-- 156
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
G P P + W + RIT+ + G L I R SD+ ++CV
Sbjct: 157 ---------GHPEPTISWKKDGS---PLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 203
Query: 2316 RNEGGESVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N GE V +L VLE RP+F + P N + + S C G+P P + W
Sbjct: 204 TNMVGERESEVAELTVLE---RPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
+G P+S +Y I + + I K T D G Y C A N VG E L + + P
Sbjct: 259 DDGEL----PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH 313
Query: 2434 ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG----YVVDRPQINGKYILHDNG 2489
+ V + G +++ C + G P+P I W + PQ + ++ + G
Sbjct: 314 FVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 2490 TLVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTGAA 2545
L I D G YIC+ N G + + V +I PP + + P +
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
Query: 2546 FQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKC 2605
F L CVA G P P I W D L+ST +QL G L I+ + D+G Y C
Sbjct: 433 FVLSCVATGSPVPTILWR-KDGVLVSTQDSR----IKQLE-NGVLQIRYAKLGDTGRYTC 486
Query: 2606 TAKNPLGSDYAATYIQV 2622
A P G + YI+V
Sbjct: 487 IASTPSGEATWSAYIEV 503
Score = 116 bits (290), Expect = 3e-25
Identities = 92/326 (28%), Positives = 143/326 (43%), Gaps = 30/326 (9%)
Query: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVL 1703
+ E+P V + ++ + + A CEA G+P+PT+ W + L SR ++
Sbjct: 219 VLERPSFVK-RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP------KSRYEIR 271
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTV 1763
+ TL I++V D G Y C A N+ G TL+V P +++ R + + + G TV
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL--GRTV 329
Query: 1764 ELKCRAEGRPSPTVTWI---LANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKC 1820
+C A G P P + W N + Q S + V+ G L + N+ D G+Y C
Sbjct: 330 TFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYIC 389
Query: 1821 VASNPGGQ---DSLLVKIQVIA--APPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVY 1875
N G + L VIA PPVI + V G + L C A G+P P++
Sbjct: 390 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTIL 448
Query: 1876 WVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTME 1935
W DG V +S++ NG L IR D G Y CIA++ +G + ++
Sbjct: 449 W-RKDGVLVST---QDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
Query: 1936 E--------RVTSPRIEAASQKRTEV 1953
E R T P + ++ + EV
Sbjct: 505 EFGVPVQPPRPTDPNLIPSAPSKPEV 530
Score = 70.5 bits (171), Expect = 2e-11
Identities = 49/175 (28%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYV--SEDGRILIDKSGKLELQMA 541
+ V +G TV C G+P P + W + Y R + ++G L +
Sbjct: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVE----AYQENGIHHTVFIGETLDLPCHS 597
D G Y C + N + I + V + + + ++ ++ TV + T L C +
Sbjct: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P +I W G V Q SR K+ L NG L+I D G Y C+A+ PSG
Sbjct: 440 TGSPVPTILWRKDGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSG 493
Score = 66.2 bits (160), Expect = 4e-10
Identities = 50/172 (29%), Positives = 71/172 (41%), Gaps = 15/172 (8%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V + C +GDP P V W DG ++ Y D L+++ + D
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH-------TLKIRKVTAGDM 286
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C++ N + +TV EP + V +G T+ C +TG P +I
Sbjct: 287 GSYTCVAENMVGKAEASATLTVQEP--PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 344
Query: 607 WVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
W G+ N+L+ QSS V G L I V D GYY C N +G
Sbjct: 345 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 396
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 11/170 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W G +V ++ SG L
Sbjct: 43 GEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 101
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D GVY C++ NY + V L + +++N V +GE + C G P+
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 604 SISWVIPGNNVLYQSSRDKKV-LNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ISW G+ + +D+++ + G L I D G Y CV N G
Sbjct: 162 TISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ TV V GT L+C G P P + W DG V ++D RI ++G L+++ A
Sbjct: 423 VNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVS----TQDSRIKQLENGVLQIRYAK 477
Query: 543 SFDTGVYHCISS 554
DTG Y CI+S
Sbjct: 478 LGDTGRYTCIAS 489
Score = 41.6 bits (96), Expect = 0.010
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 8/92 (8%)
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
+PPRI P IV++ G L+C A G P P I W + + R+H L
Sbjct: 27 FPPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH--RMLL 83
Query: 2586 LQGTL-----VIQNPQTSDSGIYKCTAKNPLG 2612
G+L V D G+Y C A+N LG
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 171 bits (432), Expect = 1e-41
Identities = 172/685 (25%), Positives = 275/685 (40%), Gaps = 89/685 (12%)
Query: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
PP I+E +IV GE L C A+G P P++ W S L +G
Sbjct: 67 PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
Query: 1901 TLYIRNLASS-----DRGTYECIATSSTG------SERRVVMLTMEERVTSPRIEAASQK 1949
+L+ + D G Y C+A + G + V +L + R + A
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA--- 182
Query: 1950 RTEVNFGDKLLLNCSAT-GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
G+ ++ C G P+P I W+ + D+ R+ G L I +
Sbjct: 183 -----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI-----TIRGGKLMITYTRK 232
Query: 2009 KDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV 2067
D+G Y+CV N +G+ + + +++ +P+ + V +F+ C+A G PV
Sbjct: 233 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK--CEARGDPV 290
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
P + W DG + + RY + ++ TL KV + G YTC A+N +GK
Sbjct: 291 PTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 338
Query: 2128 DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSI 2187
E LTV P ++ + G T CE TG+P+P IFW + + FS
Sbjct: 339 AEASATLTV--QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 396
Query: 2188 ------DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD-DTKMY--KLDVVS--KPPL 2236
R++ G LTI V+ D G Y+C N +G TK Y DV++ PP+
Sbjct: 397 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 456
Query: 2237 INGLYTNRTV-IKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKN 2295
I N+TV + T V C A G+P P ++W D + ++ SRI +N
Sbjct: 457 IRQGPVNQTVAVDGTFV------LSCVATGSPVPTILW-RKDGVLVST--QDSRIKQLEN 507
Query: 2296 GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKST 2355
G L+IR +L D+ + C+A GE+ +EV E + Q + T
Sbjct: 508 GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF------------GVPVQPPRPT 555
Query: 2356 ALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARN 2415
N PE+ + N S P A+ S+II + ++ A N
Sbjct: 556 DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG--ATPTSYIIEAFSHASGSSWQTVAEN 613
Query: 2416 KVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD 2475
+ L+ + L A GIS S +SD + ++ +P+ VD
Sbjct: 614 VKTETSAIKGLKPNAIYLFLVRA-ANAYGISDPSQ----ISDPVKTQDV---LPTSQGVD 665
Query: 2476 RPQIN---GKYILHDNGTLVIKEAT 2497
Q+ G +LH + V+ ++
Sbjct: 666 HKQVQRELGNAVLHLHNPTVLSSSS 690
Score = 161 bits (407), Expect = 9e-39
Identities = 139/494 (28%), Positives = 209/494 (42%), Gaps = 37/494 (7%)
Query: 1743 YPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVD 1802
+PPRI+E + ++ V G L C+AEGRP+PT+ W + V ++ ++
Sbjct: 66 FPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
Query: 1803 GTL----VLH-NLSIYDRGFYKCVASNPGGQD-SLLVKIQVIAAPPVILEQRRQVIVGTW 1856
G+L ++H S D G Y CVA N G+ S ++V + V+V
Sbjct: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV- 183
Query: 1857 GESLKLPC-TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTY 1915
GE + C +G P+P++ W DG+ PL + ++ + G L I SD G Y
Sbjct: 184 GEPAVMECQPPRGHPEPTISW-KKDGS---PLDDKDERITI-RGGKLMITYTRKSDAGKY 238
Query: 1916 ECIATSSTGS-ERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIM 1974
C+ T+ G E V LT+ ER + + V D C A G+P P +
Sbjct: 239 VCVGTNMVGERESEVAELTVLERPSFVK----RPSNLAVTVDDSAEFKCEARGDPVPTVR 294
Query: 1975 WRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLR 2034
WR D S + + +L I VT D G Y CVA N +G ++++
Sbjct: 295 WR------KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
Query: 2035 LKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRT 2093
P + R QV+ G+ C+A+G+P P I W + + Q S +
Sbjct: 349 EPPHFVVKP---RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS---S 402
Query: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA----APRIRQSNKT 2149
R+++ G L V ++ G Y C N G K +L V P + +
Sbjct: 403 SRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 462
Query: 2150 NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSG 2209
N+ + T VL C TG P P I W ++S R NG L I KL D+G
Sbjct: 463 NQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 521
Query: 2210 EYVCVARNPSGDDT 2223
Y C+A PSG+ T
Sbjct: 522 RYTCIASTPSGEAT 535
Score = 154 bits (388), Expect = 1e-36
Identities = 128/506 (25%), Positives = 206/506 (40%), Gaps = 48/506 (9%)
Query: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
PRIV + + A L C+A G P PTI W + ++ K S +LP+G+
Sbjct: 68 PRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 1708 LSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGST 1762
L R+ D G Y+C A N G H V+ + ++ V G
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
Query: 1763 VELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
++C+ G P PT++W + + + + G L++ D G Y CV
Sbjct: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGGKLMITYTRKSDAGKYVCV 241
Query: 1822 ASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSD 1880
+N G ++S + ++ V+ P + +R + T +S + C A+G P P+V W D
Sbjct: 242 GTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 299
Query: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEER--- 1937
G + S+ + + TL IR + + D G+Y C+A + G LT++E
Sbjct: 300 G------ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 353
Query: 1938 VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV---DQQHRVGSWIH 1994
V PR + + RT + C ATG P+P I WR + Q + S
Sbjct: 354 VVKPRDQVVALGRT-------VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 406
Query: 1995 VYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS----LRLKPAKIDHKQYFRKQV 2050
V G L I +V D G Y+C N G + ++ + +P + + + V
Sbjct: 407 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 466
Query: 2051 LHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVG 2110
F + C A+GSPVP I W DG +++ + R NG L
Sbjct: 467 AVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQIRYAK 516
Query: 2111 VAEEGDYTCYAQNTLGKDEMKVHLTV 2136
+ + G YTC A G+ ++ V
Sbjct: 517 LGDTGRYTCIASTPSGEATWSAYIEV 542
Score = 138 bits (347), Expect = 8e-32
Identities = 135/497 (27%), Positives = 198/497 (39%), Gaps = 60/497 (12%)
Query: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA----NGSLTINKV----- 2203
+ G+ A L+C+ G P P I W + + D H +GSL ++
Sbjct: 79 VSKGEPATLNCKAEGRPTPTIEWY-KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 137
Query: 2204 KLLDSGEYVCVARNPSGD--------DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
D G YVCVARN G+ + + + D P + V++ R
Sbjct: 138 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPR-- 195
Query: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
G P P + W + RIT+ + G L I R SD+ ++CV
Sbjct: 196 ---------GHPEPTISWKKDGS---PLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 242
Query: 2316 RNEGGESVL-VVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N GE V +L VLE RP+F + P N + + S C G+P P + W
Sbjct: 243 TNMVGERESEVAELTVLE---RPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRK 297
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
+G P+S +Y I + + I K T D G Y C A N VG E L + + P
Sbjct: 298 DDGEL----PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH 352
Query: 2434 ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSG----YVVDRPQINGKYILHDNG 2489
+ V + G +++ C + G P+P I W + PQ + ++ + G
Sbjct: 353 FVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 2490 TLVIKEATAYDRGNYICKAQNSVGHTL----ITVPVMIVAYPPRITNRPPRSIVTRTGAA 2545
L I D G YIC+ N G + + V +I PP + + P +
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
Query: 2546 FQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKC 2605
F L CVA G P P I W D L+ST +QL G L I+ + D+G Y C
Sbjct: 472 FVLSCVATGSPVPTILWR-KDGVLVSTQDSR----IKQLE-NGVLQIRYAKLGDTGRYTC 525
Query: 2606 TAKNPLGSDYAATYIQV 2622
A P G + YI+V
Sbjct: 526 IASTPSGEATWSAYIEV 542
Score = 116 bits (290), Expect = 3e-25
Identities = 92/326 (28%), Positives = 143/326 (43%), Gaps = 30/326 (9%)
Query: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVL 1703
+ E+P V + ++ + + A CEA G+P+PT+ W + L SR ++
Sbjct: 258 VLERPSFVK-RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP------KSRYEIR 310
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTV 1763
+ TL I++V D G Y C A N+ G TL+V P +++ R + + + G TV
Sbjct: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL--GRTV 368
Query: 1764 ELKCRAEGRPSPTVTWI---LANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKC 1820
+C A G P P + W N + Q S + V+ G L + N+ D G+Y C
Sbjct: 369 TFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYIC 428
Query: 1821 VASNPGGQ---DSLLVKIQVIA--APPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVY 1875
N G + L VIA PPVI + V G + L C A G+P P++
Sbjct: 429 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTIL 487
Query: 1876 WVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTME 1935
W DG V +S++ NG L IR D G Y CIA++ +G + ++
Sbjct: 488 W-RKDGVLVST---QDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
Query: 1936 E--------RVTSPRIEAASQKRTEV 1953
E R T P + ++ + EV
Sbjct: 544 EFGVPVQPPRPTDPNLIPSAPSKPEV 569
Score = 70.5 bits (171), Expect = 2e-11
Identities = 49/175 (28%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYV--SEDGRILIDKSGKLELQMA 541
+ V +G TV C G+P P + W + Y R + ++G L +
Sbjct: 359 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 418
Query: 542 DSFDTGVYHCISSNYDDADILTYRITVVEPLVE----AYQENGIHHTVFIGETLDLPCHS 597
D G Y C + N + I + V + + + ++ ++ TV + T L C +
Sbjct: 419 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 478
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
TG P +I W G V Q SR K+ L NG L+I D G Y C+A+ PSG
Sbjct: 479 TGSPVPTILWRKDGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSG 532
Score = 66.2 bits (160), Expect = 4e-10
Identities = 50/172 (29%), Positives = 71/172 (41%), Gaps = 15/172 (8%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V V + C +GDP P V W DG ++ Y D L+++ + D
Sbjct: 273 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH-------TLKIRKVTAGDM 325
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASIS 606
G Y C++ N + +TV EP + V +G T+ C +TG P +I
Sbjct: 326 GSYTCVAENMVGKAEASATLTVQEP--PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 383
Query: 607 WVIPGN-NVLY-----QSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
W G+ N+L+ QSS V G L I V D GYY C N +G
Sbjct: 384 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 435
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 11/170 (6%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLEL-----QMADSF 544
G LNC +G PTP ++W G +V ++ SG L
Sbjct: 82 GEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 140
Query: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH-STGIPDA 603
D GVY C++ NY + V L + +++N V +GE + C G P+
Sbjct: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 200
Query: 604 SISWVIPGNNVLYQSSRDKKV-LNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ISW G+ + +D+++ + G L I D G Y CV N G
Sbjct: 201 TISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVG 247
Score = 42.0 bits (97), Expect = 0.008
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ TV V GT L+C G P P + W DG V ++D RI ++G L+++ A
Sbjct: 462 VNQTVAVDGTFVLSCVATGSPVPTILW-RKDGVLVS----TQDSRIKQLENGVLQIRYAK 516
Query: 543 SFDTGVYHCISS 554
DTG Y CI+S
Sbjct: 517 LGDTGRYTCIAS 528
Score = 41.6 bits (96), Expect = 0.010
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 8/92 (8%)
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
+PPRI P IV++ G L+C A G P P I W + + R+H L
Sbjct: 66 FPPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH--RMLL 122
Query: 2586 LQGTL-----VIQNPQTSDSGIYKCTAKNPLG 2612
G+L V D G+Y C A+N LG
Sbjct: 123 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 154
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 170 bits (431), Expect = 1e-41
Identities = 166/590 (28%), Positives = 245/590 (41%), Gaps = 70/590 (11%)
Query: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727
L CEA GNP P W S +D+S R ++ + I D G Y C A+N
Sbjct: 48 LHCEARGNPSPHYRWQLNGSDIDMS---MEHRYKLNGGNLVVINPNRNWDTGTYQCFATN 104
Query: 1728 LFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP-TVTWILANQTV 1786
GT +Y + ++V G V L C + WI
Sbjct: 105 SLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPS 164
Query: 1787 VSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAP----- 1841
E + SR+ V G L + + D G Y CV + S++ +V+ +P
Sbjct: 165 FVE--EDSRRFVSQETGHLYISKVEPSDVGNYTCVVT------SMVTNARVLGSPTPLVL 216
Query: 1842 ----------PVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTN 1891
P I Q + + G ++KL C A G P P + W SDG L F++
Sbjct: 217 RSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDG-----LPFSS 271
Query: 1892 S-KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKR 1950
KL FS G L I N D G+YECIA +S G LT + ++ K
Sbjct: 272 KIKLRKFS-GVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLI----KD 326
Query: 1951 TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD 2010
E+ D L C A+G+PKP W A+V ++ NG+L I +++ D
Sbjct: 327 VEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQ------IENGALTISNLSVTD 380
Query: 2011 SGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK---QVLHGKDFQVDCKASGSPV 2067
SG++ C+A NK G L+ L++ + D + K QV G +DCK SP
Sbjct: 381 SGMFQCIAENKHG--LVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPR 438
Query: 2068 PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
SW + D S R +L N+G L V A+ G YTC A+N GK
Sbjct: 439 ALSSWK-----------KGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGK 487
Query: 2128 DEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMIS-FS 2186
HL V+T RI + +N + G++ +L C+V DP I + N ++ F
Sbjct: 488 ANGTTHL-VVTEPTRITLA-PSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFK 545
Query: 2187 IDRYTFH-----ANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVV 2231
D F ++G L I ++L SG+YVC+ + +G D+ D++
Sbjct: 546 KDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQ--TGVDSVSSAADLI 593
Score = 136 bits (342), Expect = 3e-31
Identities = 153/623 (24%), Positives = 259/623 (41%), Gaps = 70/623 (11%)
Query: 1836 QVIAAPPVILEQRRQVI--VGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSK 1893
+++ PV +++ I VG+ + + L C A+G P P W L +G+++ +
Sbjct: 20 ELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQL-NGSDI---DMSMEH 75
Query: 1894 LFLFSNGTLYIRNLASS-DRGTYECIATSSTGS----ERRVVMLTMEERVTSPRIEAASQ 1948
+ + G L + N + D GTY+C AT+S G+ E ++ +E T R
Sbjct: 76 RYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMR------ 129
Query: 1949 KRTEVNFGDKLLLNCSA---TGE-PKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIG 2004
V G ++L C +GE I PS D + V G L+I
Sbjct: 130 STVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQ-----ETGHLYIS 184
Query: 2005 SVTEKDSGVYLCVARNKMGDDLIL---MHVSLRLKPAKIDHKQYFRKQ------VLHGKD 2055
V D G Y CV + + + +L + LR +++ Q G
Sbjct: 185 KVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGST 244
Query: 2056 FQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEG 2115
+++C A G+P+P+I+W DG ++ + + R++ +G L + G
Sbjct: 245 VKLECFALGNPIPQINWRRSDGLPFSSKI-------KLRKF----SGVLEIPNFQQEDAG 293
Query: 2116 DYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFW 2175
Y C A+N+ GK+ + LT A P Q K + I D+ +C +G PKP W
Sbjct: 294 SYECIAENSRGKNVARGRLTYY-AKPHWVQLIK-DVEIAVEDSLYWECRASGKPKPSYRW 351
Query: 2176 LLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPP 2235
L ++ ++ T NG+LTI+ + + DSG + C+A N G +L VV+ P
Sbjct: 352 LKNGAALV---LEERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAP 408
Query: 2236 LINGLYTNRTVIKATAVR-HSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK 2294
++ + K V+ S DC+ +P W D + RI++
Sbjct: 409 ----DFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGD----VSVQEHERISLLN 460
Query: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
+G L+I NV +D+ + C+A N+ G++ L V E PT + +G+S
Sbjct: 461 DGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTE----PTRITLAPSNMDVSVGES 516
Query: 2355 TALNCSVDGNPPPEII--WILPNGTRF---SNGPQSYQYLIASNGSFIISKTTREDAGKY 2409
L C V +P +II W NG +G + +S+G +I + +GKY
Sbjct: 517 VILPCQVQHDPLLDIIFTWYF-NGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKY 575
Query: 2410 RCAARNKVGYIEKLVILEIGQKP 2432
C + V + L + P
Sbjct: 576 VCMVQTGVDSVSSAADLIVRGSP 598
Score = 136 bits (342), Expect = 3e-31
Identities = 141/581 (24%), Positives = 234/581 (40%), Gaps = 68/581 (11%)
Query: 1958 KLLLNCSATGEPKPQIMWRLPSKAV-VDQQHRV----GSWIHVYPNGSLFIGSVTEKDSG 2012
K+ L+C A G P P W+L + + +HR G+ + + PN + D+G
Sbjct: 45 KITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNW--------DTG 96
Query: 2013 VYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISW 2072
Y C A N +G ++ +L+ A +++ + + + ++ Q G P S
Sbjct: 97 TYQCFATNSLG---TIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGP--PPHSG 151
Query: 2073 SLPDGTMINN--AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEM 2130
L + N + +DS RR+ G LY +KV ++ G+YTC + + +
Sbjct: 152 ELSYAWIFNEYPSFVEEDS----RRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARV 207
Query: 2131 KVHLTVITA---------APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSND 2181
T + P+I G T L+C G+P P+I W +D
Sbjct: 208 LGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINW--RRSD 265
Query: 2182 MISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLY 2241
+ FS +G L I + D+G Y C+A N G + +L +KP +
Sbjct: 266 GLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQ--- 322
Query: 2242 TNRTVIKATAVR-HSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEI 2300
+IK + +++CRA G P P W+ A T +NG L I
Sbjct: 323 ----LIKDVEIAVEDSLYWECRASGKPKPSYRWLKNG-----AALVLEERTQIENGALTI 373
Query: 2301 RNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNC 2359
N+ ++DS F C+A N+ G +L+V + P F +NP + + Q+G +L+C
Sbjct: 374 SNLSVTDSGMFQCIAENKHGLVYSSAELKV--VASAPDFSKNPMKKLVQVQVGSLVSLDC 431
Query: 2360 SVDGNPPPEIIWILPNGTRFSNGPQSYQ----YLIASNGSFIISKTTREDAGKYRCAARN 2415
+P W G S Q + ++G I+ T+ DAG Y C A N
Sbjct: 432 KPRASPRALSSW--------KKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAEN 483
Query: 2416 KVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD 2475
+ G L + +P +T AP + GES+ L C P +I +T +
Sbjct: 484 QFGKANGTTHLVV-TEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALA 542
Query: 2476 RPQINGKYIL----HDNGTLVIKEATAYDRGNYICKAQNSV 2512
+ +G + +G L+I+ G Y+C Q V
Sbjct: 543 DFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGV 583
Score = 129 bits (324), Expect = 4e-29
Identities = 175/728 (24%), Positives = 287/728 (39%), Gaps = 76/728 (10%)
Query: 1763 VELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLS-IYDRGFYKCV 1821
+ L C A G PSP W L S+ G LV+ N + +D G Y+C
Sbjct: 46 ITLHCEARGNPSPHYRWQLNG----SDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCF 101
Query: 1822 ASNP-GGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTP----QPSVYW 1876
A+N G S K+Q + R V V G+ + L C G P + S W
Sbjct: 102 ATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVRE-GQGVVLLC---GPPPHSGELSYAW 157
Query: 1877 VLSDGTEVKPLQFTNSKLFLF-SNGTLYIRNLASSDRGTYECIATSST------GSERRV 1929
+ + E +S+ F+ G LYI + SD G Y C+ TS GS +
Sbjct: 158 IFN---EYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPL 214
Query: 1930 VMLT---MEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ 1986
V+ + M E P+IE + G + L C A G P PQI WR +
Sbjct: 215 VLRSDGVMGE--YEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSK 272
Query: 1987 HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF 2046
++ + +G L I + ++D+G Y C+A N G ++ ++ KP + Q
Sbjct: 273 IKLRKF-----SGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWV---QLI 324
Query: 2047 RKQVLHGKD-FQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLY 2105
+ + +D +C+ASG P P W ++ T NG L
Sbjct: 325 KDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALV------------LEERTQIENGALT 372
Query: 2106 FNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRI-RQSNKTNKRIKAGDTAVLDCE 2164
+ + V + G + C A+N G L V+ +AP + K +++ G LDC+
Sbjct: 373 ISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCK 432
Query: 2165 VTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTK 2224
P+ W D+ +R + +G L I V D+G Y C+A N G
Sbjct: 433 PRASPRALSSW--KKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANG 490
Query: 2225 MYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDN----IF 2280
L VV++P I +N V +V C+ + P ++++ N F
Sbjct: 491 TTHL-VVTEPTRITLAPSNMDVSVGESV-----ILPCQVQHDPLLDIIFTWYFNGALADF 544
Query: 2281 LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
+ ++ +G L IRN++L S ++C+ + G +SV +++ R +
Sbjct: 545 KKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQT-GVDSV----SSAADLIVRGSPG 599
Query: 2341 NPFNEKIVAQLGKSTALNCSVDG--NPPPEIIWILPNGTRFSNGPQSY----QYLIASNG 2394
P N K V ++ +TA +G N P I + + T FS G Q+ + +
Sbjct: 600 PPENVK-VDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTH 658
Query: 2395 SFIISKTTREDAGKYRCAARNKVGYIE-KLVILEIGQKPVILTYAPGTVKGISGESLSLH 2453
+ + + ++R A NK+G E L ++ + + P V G G L
Sbjct: 659 TATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELV 718
Query: 2454 CVSDGIPK 2461
D +P+
Sbjct: 719 ITWDPVPE 726
Score = 126 bits (317), Expect = 2e-28
Identities = 122/476 (25%), Positives = 185/476 (38%), Gaps = 41/476 (8%)
Query: 2161 LDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSG 2220
L CE G+P P W L +D+ RY + + IN + D+G Y C A N G
Sbjct: 48 LHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLG 107
Query: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
+VS+ + Y K + ++ P P + IF
Sbjct: 108 --------TIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIF 159
Query: 2281 LTAPYY----GSRITVHKNGTLEIRNVRLSDSADFICV-------ARNEGGESVLVVQLE 2329
P + R + G L I V SD ++ CV AR G + LV++ +
Sbjct: 160 NEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSD 219
Query: 2330 VLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL 2389
+ P F E + A G + L C GNP P+I W +G FS+ + ++
Sbjct: 220 GVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKF- 278
Query: 2390 IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGES 2449
+G I +EDAG Y C A N G L KP + + +S
Sbjct: 279 ---SGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVE-DS 334
Query: 2450 LSLHCVSDGIPKPNIKWTMPSGYVV--DRPQINGKYILHDNGTLVIKEATAYDRGNYICK 2507
L C + G PKP+ +W +V +R QI +NG L I + D G + C
Sbjct: 335 LYWECRASGKPKPSYRWLKNGAALVLEERTQI-------ENGALTISNLSVTDSGMFQCI 387
Query: 2508 AQNSVGHTLITVPVMIVAYPPRITNRPPRSIV-TRTGAAFQLHCVALGVPKPEITWEMPD 2566
A+N G + + +VA P + P + +V + G+ L C P+ +W+ D
Sbjct: 388 AENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGD 447
Query: 2567 HSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
S+ + H L G L I N +D+G Y C A+N G T++ V
Sbjct: 448 VSV-------QEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVV 496
Score = 123 bits (309), Expect = 2e-27
Identities = 144/581 (24%), Positives = 232/581 (39%), Gaps = 60/581 (10%)
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
K + C+A G+P P W L +G+ I+ +M+ RY L + N +
Sbjct: 44 KKITLHCEARGNPSPHYRWQL-NGSDIDMSME--------HRYKLNGGNLVVINPNRNWD 94
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKP-- 2171
G Y C+A N+LG + + ++ ++ G VL C P P
Sbjct: 95 TGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC----GPPPHS 150
Query: 2172 ---KIFWLLPSNDMISFSID---RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKM 2225
W+ N+ SF + R+ G L I+KV+ D G Y CV + + +
Sbjct: 151 GELSYAWIF--NEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVL 208
Query: 2226 YK-LDVVSKPPLINGLYTNRTVIK----ATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
+V + + G Y + ++ A + S +C A G P P++ W D +
Sbjct: 209 GSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGL- 267
Query: 2281 LTAPYYGSRITVHK-NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF 2339
+ S+I + K +G LEI N + D+ + C+A N G++V +L +P +
Sbjct: 268 ----PFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYA---KPHW 320
Query: 2340 RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIIS 2399
+ +A + S C G P P W L NG ++ NG+ IS
Sbjct: 321 VQLIKDVEIA-VEDSLYWECRASGKPKPSYRW-LKNGAALVLEERTQ----IENGALTIS 374
Query: 2400 KTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAP--GTVKGISGESLSLHCVSD 2457
+ D+G ++C A NK G + L++ + P V+ G +SL C
Sbjct: 375 NLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPR 434
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
P+ W V + +I+ +L+D G L I T D G Y C A+N G
Sbjct: 435 ASPRALSSWKKGDVSVQEHERIS---LLNDGG-LKIANVTKADAGTYTCMAENQFGKANG 490
Query: 2518 TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKER 2577
T ++V P RIT P V+ G + L C P +I + + L+ K+
Sbjct: 491 TTH-LVVTEPTRITLAPSNMDVS-VGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDG 548
Query: 2578 TH-----GSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
+H GS G L+I+N Q SG Y C + + S
Sbjct: 549 SHFEKVGGSSS----GDLMIRNIQLKHSGKYVCMVQTGVDS 585
Score = 88.2 bits (217), Expect = 1e-16
Identities = 94/379 (24%), Positives = 143/379 (37%), Gaps = 40/379 (10%)
Query: 2261 CRAEGTPSPEVMW-IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEG 2319
C A G PSP W + +I ++ + R ++ + I R D+ + C A N
Sbjct: 50 CEARGNPSPHYRWQLNGSDIDMSMEH---RYKLNGGNLVVINPNRNWDTGTYQCFATNSL 106
Query: 2320 GESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPE-----IIWILP 2374
G +V + L+ F+ + + G+ L C PPP WI
Sbjct: 107 G--TIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCG----PPPHSGELSYAWIFN 160
Query: 2375 NGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKV------GYIEKLVILEI 2428
F S +++ G ISK D G Y C + V G LV+
Sbjct: 161 EYPSFVE-EDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSD 219
Query: 2429 G----QKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYI 2484
G +P I P T+ G ++ L C + G P P I W G K+
Sbjct: 220 GVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKF- 278
Query: 2485 LHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGA 2544
+G L I D G+Y C A+NS G + + A P + I
Sbjct: 279 ---SGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSL 335
Query: 2545 AFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYK 2604
++ C A G PKP W +L+ +ERT G L I N +DSG+++
Sbjct: 336 YWE--CRASGKPKPSYRWLKNGAALVL---EERTQIEN-----GALTISNLSVTDSGMFQ 385
Query: 2605 CTAKNPLGSDYAATYIQVI 2623
C A+N G Y++ ++V+
Sbjct: 386 CIAENKHGLVYSSAELKVV 404
Score = 83.2 bits (204), Expect = 3e-15
Identities = 69/270 (25%), Positives = 110/270 (40%), Gaps = 17/270 (6%)
Query: 1660 IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRG 1719
I + C A G P P+ W + + L L +R Q + NG L+I + + D G
Sbjct: 329 IAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQ------IENGALTISNLSVTDSG 382
Query: 1720 QYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKE-ITVHSGSTVELKCRAEGRPSPTVT 1778
+ C A N G + L VV+ P + K+ + V GS V L C+ P +
Sbjct: 383 MFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSS 442
Query: 1779 WILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVI 1838
W + +V Q + + DG L + N++ D G Y C+A N G+ + + V
Sbjct: 443 WKKGDVSV-----QEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVT 497
Query: 1839 AAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVY--WVLSDG-TEVKPLQFTNSKLF 1895
+ L + + GES+ LPC + P + W + + K K+
Sbjct: 498 EPTRITLAPSNMDV--SVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVG 555
Query: 1896 LFSNGTLYIRNLASSDRGTYECIATSSTGS 1925
S+G L IRN+ G Y C+ + S
Sbjct: 556 GSSSGDLMIRNIQLKHSGKYVCMVQTGVDS 585
Score = 62.0 bits (149), Expect = 7e-09
Identities = 45/174 (25%), Positives = 80/174 (45%), Gaps = 13/174 (7%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDK-SGKLELQMADSFDTGV 548
G TV L C G+P P ++W +DG P+ S +I + K SG LE+ D G
Sbjct: 242 GSTVKLECFALGNPIPQINWRRSDG----LPFSS---KIKLRKFSGVLEIPNFQQEDAGS 294
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWV 608
Y CI+ N ++ R+T + + + ++L C ++G P S W+
Sbjct: 295 YECIAENSRGKNVARGRLTYYAKPHWVQLIKDVE--IAVEDSLYWECRASGKPKPSYRWL 352
Query: 609 IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV 662
G ++ + ++ + NG L I ++ D G ++C+A N G+ + ++ V
Sbjct: 353 KNGAALVLE---ERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKV 403
Score = 53.1 bits (126), Expect = 3e-06
Identities = 67/295 (22%), Positives = 112/295 (37%), Gaps = 38/295 (12%)
Query: 380 LYSDSPLILERSHLLSE-TPQLYYKYKQVAPKPEDIFTNIEADLRADP----SWLMQDQI 434
L S +PL+L ++ E P++ ++ + P + +E +P +W D +
Sbjct: 208 LGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGL 267
Query: 435 SLQLNRTATTFS-TLQI---------QYSSDAQITLPRAEMRP-----VKHKWTMISRDN 479
FS L+I Y A+ + + R K W + +D
Sbjct: 268 PFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDV 327
Query: 480 NTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
+E ++ C G P P WL K A V E+ + ++G L +
Sbjct: 328 EIAVEDSLY------WECRASGKPKPSYRWL-----KNGAALVLEERTQI--ENGALTIS 374
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI--GETLDLPCHS 597
D+G++ CI+ N + + VV + + +N + V + G + L C
Sbjct: 375 NLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPD-FSKNPMKKLVQVQVGSLVSLDCKP 433
Query: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
P A SW +V Q +LN+G L+I VT D G Y C+A N G
Sbjct: 434 RASPRALSSW--KKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFG 486
Score = 48.1 bits (113), Expect = 1e-04
Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 15/182 (8%)
Query: 2430 QKPVILTYAPGTVKGISGES--LSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHD 2487
Q PV + ++ + E ++LHC + G P P+ +W + +G +D + +Y L+
Sbjct: 24 QGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQL-NGSDIDM-SMEHRYKLNG 81
Query: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQ 2547
+VI +D G Y C A NS+G + + AY + ++ R G
Sbjct: 82 GNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVV 141
Query: 2548 LHCVALGVP----KPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
L C G P + W ++ R E G L I + SD G Y
Sbjct: 142 LLC---GPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQE----TGHLYISKVEPSDVGNY 194
Query: 2604 KC 2605
C
Sbjct: 195 TC 196
Score = 47.8 bits (112), Expect = 1e-04
Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 16/186 (8%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
V VG V L+C + P W D S V E RI + G L++ D
Sbjct: 421 VQVGSLVSLDCKPRASPRALSSWKKGDVS------VQEHERISLLNDGGLKIANVTKADA 474
Query: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP--DAS 604
G Y C++ N T + V EP + + V +GE++ LPC P D
Sbjct: 475 GTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNM--DVSVGESVILPCQVQHDPLLDII 532
Query: 605 ISWVIPGNNVLYQ--SSRDKKV--LNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV 660
+W G ++ S +KV ++G L I + K G Y C+ +GVD +
Sbjct: 533 FTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMV--QTGVDSVSSAA 590
Query: 661 SVKMKG 666
+ ++G
Sbjct: 591 DLIVRG 596
Score = 43.1 bits (100), Expect = 0.004
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 22/167 (13%)
Query: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCI 552
+ L+C +G+P+PH W L +GS + +S + R ++ + + ++DTG Y C
Sbjct: 46 ITLHCEARGNPSPHYRWQL-NGSDID---MSMEHRYKLNGGNLVVINPNRNWDTGTYQCF 101
Query: 553 SSNYDDADILTYRITVVEPLVEAYQEN---GIHHTVFIGETLDL------PCHSTGIPDA 603
++N L ++ L AY EN + TV + E + P HS +
Sbjct: 102 ATN-----SLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHS---GEL 153
Query: 604 SISWVI-PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
S +W+ + + + SR G L I +V P D G Y CV +
Sbjct: 154 SYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTS 200
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 169 bits (429), Expect = 3e-41
Identities = 176/701 (25%), Positives = 271/701 (38%), Gaps = 91/701 (12%)
Query: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDR---- 1912
G L C + VYW+L DG P+Q T + F+ G+ + A+ DR
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLL-DGA---PVQDTERR---FAQGSSL--SFAAVDRLQDS 96
Query: 1913 GTYECIATSS-TGSERRVVMLTMEER--------VTSPRIEAASQKRTEVNFGDKLLLNC 1963
GT++C+A TG E R + + + P EA Q +T+V L C
Sbjct: 97 GTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVT------LRC 150
Query: 1964 SATGEPKPQIMWRLPSKAVVDQQ--HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNK 2021
G P+P W + D Q H V S +L + + SG+Y C A +
Sbjct: 151 HIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KERNLTLRPAGPEHSGLYSCCAHSA 205
Query: 2022 MGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQV--------DCKASGSPVPEISWS 2073
G + +L + + F + VL +D V C+ S P P + W
Sbjct: 206 FGQACSSQNFTLSIAD------ESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
Query: 2074 LPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKD---EM 2130
D T I N + RR T+F NG+L +V G Y C Q G E
Sbjct: 260 FEDETPITNRSRPP----HLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEA 315
Query: 2131 KVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDC-EVTGDPKPKIFWLLPSNDMISFSIDR 2189
+HL I P T AG + C G P+P ++W + +
Sbjct: 316 TLHLAEIEDMPLFEPRVFT-----AGSEERVTCLPPKGLPEPSVWW---EHAGVRLPTHG 367
Query: 2190 YTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKA 2249
+ L + + D+G Y C A N +G + + V + P + ++
Sbjct: 368 RVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLE--- 424
Query: 2250 TAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSA 2309
+ DC + TP P V+W + SR V KNGTL I +V + D
Sbjct: 425 ---EGKPGYLDCLTQATPKPTVVWYRNQMLISE----DSRFEVFKNGTLRINSVEVYDGT 477
Query: 2310 DFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEI 2369
+ C++ G +++VLE L+ F P + + K + CS G P I
Sbjct: 478 WYRCMSSTPAGSIEAQARVQVLEKLK---FTPPPQPQQCMEFDKEATVPCSATGREKPTI 534
Query: 2370 IWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARN-KVGYIEKLVILEI 2428
W +G+ +++ + G+ ++ TR+DAG Y C A N G I V L +
Sbjct: 535 KWERADGSSLP------EWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTV 588
Query: 2429 GQKPVILTY--APGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILH 2486
V +T+ P G + L C + G PKP I+W ++D ++ + +
Sbjct: 589 A---VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIF 644
Query: 2487 DNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYP 2527
NG+LVI + D G Y C A NS P+ +V P
Sbjct: 645 QNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP 685
Score = 167 bits (424), Expect = 1e-40
Identities = 155/610 (25%), Positives = 248/610 (40%), Gaps = 63/610 (10%)
Query: 1642 RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQ 1701
++I P ++ A+ I + L C G+P PT W R G LS + N V
Sbjct: 122 KWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFR--DGTPLSDGQSNHTVS 179
Query: 1702 VLPNGTLSIQRVEIQDRGQYLCSASNLFG--TDHLHVTLSVVSYPPRILERRTKEITVHS 1759
L+++ + G Y C A + FG + TLS+ + +++ V
Sbjct: 180 -SKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVAR 238
Query: 1760 GSTVELKCRAEGRPSPTVTWILANQTVVSESSQGS--RQAVVTVDGTLVLHNLSIYDRGF 1817
C+ +P P++ W+ ++T ++ S+ R+A V +G+L+L + + G
Sbjct: 239 YEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGI 298
Query: 1818 YKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVI-----------VGTWGESLKLPC-T 1865
Y+C+ G PP+ILE + V T G ++ C
Sbjct: 299 YRCIGQGQRG-------------PPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLP 345
Query: 1866 AKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGS 1925
KG P+PSV+W E ++ L + N+A SD G Y C A + G
Sbjct: 346 PKGLPEPSVWW------EHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
Query: 1926 ERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQ 1985
R+ V +T+ T P Q +++ G L+C PKP ++W ++ ++ +
Sbjct: 400 RRQDVNITV---ATVPSWLKKPQD-SQLEEGKPGYLDCLTQATPKPTVVW-YRNQMLISE 454
Query: 1986 QHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQY 2045
R V+ NG+L I SV D Y C++ G V + L+ K
Sbjct: 455 DSR----FEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQV-LEKLKFTPPPQ 509
Query: 2046 FRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLY 2105
++ + K+ V C A+G P I W DG+ + + N GTL+
Sbjct: 510 PQQCMEFDKEATVPCSATGREKPTIKWERADGSSL-------------PEWVTDNAGTLH 556
Query: 2106 FNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEV 2165
F +V + G+YTC A N + +++ H+ + A + + G TA+L CE
Sbjct: 557 FARVTRDDAGNYTCIASNG-PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEA 615
Query: 2166 TGDPKPKIFWLLPSNDMISFSI-DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTK 2224
GDPKP I W + + R NGSL I+ V DSG Y C+A N
Sbjct: 616 QGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 675
Query: 2225 MYKLDVVSKP 2234
L VV KP
Sbjct: 676 EAPLYVVDKP 685
Score = 161 bits (408), Expect = 7e-39
Identities = 170/694 (24%), Positives = 272/694 (39%), Gaps = 73/694 (10%)
Query: 1760 GSTVELKCRAEGRPSPTVTWILANQTVVSES---SQGSRQAVVTVDGTLVLHNLSIYDRG 1816
G L+C E V W+L V +QGS + VD + D G
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVD--------RLQDSG 97
Query: 1817 FYKCVASNP-GGQDSLLVK----IQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQ 1871
++CVA + G+++ I+ I A PV+L+ + L C G P+
Sbjct: 98 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 1872 PSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG---SERR 1928
P+ W DGT + Q ++ N TL R G Y C A S+ G S +
Sbjct: 158 PTYQW-FRDGTPLSDGQSNHTVSSKERNLTL--RPAGPEHSGLYSCCAHSAFGQACSSQN 214
Query: 1929 VVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHR 1988
+ +E R+ A Q + ++ + +C + +P P + W + + + R
Sbjct: 215 FTLSIADESFA--RVVLAPQDVVVARY-EEAMFHCQFSAQPPPSLQWLFEDETPITNRSR 271
Query: 1989 VGSWIH--VYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF 2046
V+ NGSL + V +++G+Y C+ + + G +IL L A+I+ F
Sbjct: 272 PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIIL---EATLHLAEIEDMPLF 328
Query: 2047 RKQVLH-GKDFQVDC-KASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTL 2104
+V G + +V C G P P + W G + + GH L
Sbjct: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHA-GVRLPTHGRVYQKGHE-----------L 376
Query: 2105 YFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCE 2164
+ ++ G YTC+A N G+ V++TV T +++ + +++ G LDC
Sbjct: 377 VLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQ--DSQLEEGKPGYLDCL 434
Query: 2165 VTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTK 2224
PKP + W N M+ R+ NG+L IN V++ D Y C++ P+G
Sbjct: 435 TQATPKPTVVWY--RNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEA 492
Query: 2225 MYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAP 2284
++ V+ K +T + + C A G P + W D L
Sbjct: 493 QARVQVLEKLK-----FTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLP-- 545
Query: 2285 YYGSRITVHKNGTLEIRNVRLSDSADFICVARN-EGGESVLVVQLEVLEMLRRPTFRNPF 2343
GTL V D+ ++ C+A N G+ VQL V + TF+
Sbjct: 546 ----EWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI---TFKVEP 598
Query: 2344 NEKIVAQLGKSTALNCSVDGNPPPEIIWI----LPNGTRFSNGPQSYQYLIASNGSFIIS 2399
V Q G + L C G+P P I W + + T+ GP+ + I NGS +I
Sbjct: 599 ERTTVYQ-GHTALLQCEAQGDPKPLIQWKGKDRILDPTKL--GPRMH---IFQNGSLVIH 652
Query: 2400 KTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
ED+G+Y C A N L + KPV
Sbjct: 653 DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPV 686
Score = 152 bits (385), Expect = 3e-36
Identities = 160/658 (24%), Positives = 261/658 (39%), Gaps = 98/658 (14%)
Query: 1696 QNSRVQVLPNGTLSIQRVE-IQDRGQYLCSA-SNLFGTDHLHVTLSV----VSYPPRILE 1749
Q++ + +LS V+ +QD G + C A ++ G + S + P +L+
Sbjct: 73 QDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLK 132
Query: 1750 RRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHN 1809
E + + V L+C +G P PT W + T +S+ S V + + L L
Sbjct: 133 HPASEAEIQPQTQVTLRCHIDGHPRPTYQW-FRDGTPLSDGQ--SNHTVSSKERNLTLRP 189
Query: 1810 LSIYDRGFYKCVASNPGGQ----DSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCT 1865
G Y C A + GQ + + I + V+L + V+V + E++ C
Sbjct: 190 AGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAP-QDVVVARYEEAM-FHCQ 247
Query: 1866 AKGTPQPSVYWVLSDGTEV----KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATS 1921
P PS+ W+ D T + +P + +F+NG+L + + + G Y CI
Sbjct: 248 FSAQPPPSLQWLFEDETPITNRSRPPHLRRAT--VFANGSLLLTQVRPRNAGIYRCIGQG 305
Query: 1922 STGS----ERRVVMLTMEER-VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMW- 1975
G E + + +E+ + PR+ A + K G P+P + W
Sbjct: 306 QRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK--------GLPEPSVWWE 357
Query: 1976 ----RLPSKAVVDQQHRVGSWIHVYPNG-SLFIGSVTEKDSGVYLCVARNKMGDDLILMH 2030
RLP+ VY G L + ++ E D+GVY C A N G ++
Sbjct: 358 HAGVRLPTHG------------RVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVN 405
Query: 2031 VSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSG 2090
+++ P+ + Q Q+ GK +DC +P P + W N + ++DS
Sbjct: 406 ITVATVPSWLKKPQ--DSQLEEGKPGYLDCLTQATPKPTVVW------YRNQMLISEDS- 456
Query: 2091 HRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVI-----TAAPRIRQ 2145
R+ +F NGTL N V V + Y C + G E + + V+ T P+ +Q
Sbjct: 457 ----RFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQ 512
Query: 2146 SNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKL 2205
+ +K A + C TG KP I W S+ + G+L +V
Sbjct: 513 CMEFDKE------ATVPCSATGREKPTIKWERADGS----SLPEWVTDNAGTLHFARVTR 562
Query: 2206 LDSGEYVCVARN-PSGDDTKMYKLDVV-----SKPPLINGLYTNRTVIKATAVRHSKKHF 2259
D+G Y C+A N P G +L V P +Y T +
Sbjct: 563 DDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL-----------L 611
Query: 2260 DCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317
C A+G P P + W D I L G R+ + +NG+L I +V DS + C+A N
Sbjct: 612 QCEAQGDPKPLIQWKGKDRI-LDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGN 668
Score = 144 bits (362), Expect = 1e-33
Identities = 161/698 (23%), Positives = 268/698 (38%), Gaps = 91/698 (13%)
Query: 1956 GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE-KDSGVY 2014
G + LL C + W L V D + R SL +V +DSG +
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQ------GSSLSFAAVDRLQDSGTF 99
Query: 2015 LCVARNKM-GDDLILMHVSLRLK-----PAKIDHKQYFRKQVLHGKDFQVDCKASGSPVP 2068
CVAR+ + G++ + S +K P + H ++ + C G P P
Sbjct: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPAS-EAEIQPQTQVTLRCHIDGHPRP 158
Query: 2069 EISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKD 2128
W DGT +++ + R TL G G Y+C A + G+
Sbjct: 159 TYQW-FRDGTPLSDGQSNHTVSSKERNLTL--------RPAGPEHSGLYSCCAHSAFGQA 209
Query: 2129 EMKVHLTVITAAPRIRQSNKTNKRIKAG--DTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
+ T+ A + + + + A+ C+ + P P + WL I+
Sbjct: 210 CSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNR 269
Query: 2187 -----IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD----DTKMYKLDVVSKPPLI 2237
+ R T ANGSL + +V+ ++G Y C+ + G + ++ ++ P
Sbjct: 270 SRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFE 329
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
++T + + T + +G P P V W ++ + P +G K
Sbjct: 330 PRVFTAGSEERVTCLP---------PKGLPEPSVWW---EHAGVRLPTHGR--VYQKGHE 375
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTA 2356
L + N+ SD+ + C A N G+ V + V + P++ + P + ++ + GK
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATV---PSWLKKPQDSQL--EEGKPGY 430
Query: 2357 LNCSVDGNPPPEIIW-----ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRC 2411
L+C P P ++W ++ +RF + NG+ I+ D YRC
Sbjct: 431 LDCLTQATPKPTVVWYRNQMLISEDSRFE---------VFKNGTLRINSVEVYDGTWYRC 481
Query: 2412 AARNKVGYIEKLVILEIGQKPVILTYAPGTVKGIS-GESLSLHCVSDGIPKPNIKWTMPS 2470
+ G IE +++ +K + T P + + + ++ C + G KP IKW
Sbjct: 482 MSSTPAGSIEAQARVQVLEK-LKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
Query: 2471 GYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSV-----GHTLITVPVMIVA 2525
G + +++ + GTL T D GNY C A N H +TV V I
Sbjct: 541 GSSLP------EWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFIT- 593
Query: 2526 YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLH 2585
P R+ V + A L C A G PKP I W+ D L T R H +
Sbjct: 594 ----FKVEPERTTVYQGHTAL-LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMH----IF 644
Query: 2586 LQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
G+LVI + DSG Y C A N + + V+
Sbjct: 645 QNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 682
Score = 58.2 bits (139), Expect = 1e-07
Identities = 48/186 (25%), Positives = 72/186 (38%), Gaps = 17/186 (9%)
Query: 497 CPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNY 556
C G P + W ADGS + + D +G L D G Y CI+SN
Sbjct: 524 CSATGREKPTIKWERADGSSLP--------EWVTDNAGTLHFARVTRDDAGNYTCIASNG 575
Query: 557 DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLY 616
I + V + ++ TV+ G T L C + G P I W G + +
Sbjct: 576 PQGQIRAHVQLTVAVFI-TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW--KGKDRIL 632
Query: 617 QSSR---DKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHD 673
++ + NG+L I V P+D G Y C+A N + + V +P+ +
Sbjct: 633 DPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV---DKPVPEE 689
Query: 674 GETEGS 679
E GS
Sbjct: 690 SEGPGS 695
Score = 57.0 bits (136), Expect = 2e-07
Identities = 53/189 (28%), Positives = 78/189 (41%), Gaps = 18/189 (9%)
Query: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
L+C Q P P V W +SED R + K+G L + + +D Y C+SS
Sbjct: 431 LDCLTQATPKPTVVWYR------NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSS 484
Query: 555 NYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNV 614
+ R+ V+E L F E +PC +TG +I W +
Sbjct: 485 TPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEA-TVPCSATGREKPTIKWERADGSS 543
Query: 615 LYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN-PSGVDFLIFQVSV------KMKGQ 667
L + D N GTL +VT D G Y C+A+N P G Q++V K++ +
Sbjct: 544 LPEWVTD----NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPE 599
Query: 668 RPLEHDGET 676
R + G T
Sbjct: 600 RTTVYQGHT 608
Score = 49.3 bits (116), Expect = 5e-05
Identities = 45/155 (29%), Positives = 67/155 (43%), Gaps = 11/155 (7%)
Query: 498 PGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYD 557
P +G P P V W + + VR P GR+ K +L L D GVY C ++N
Sbjct: 345 PPKGLPEPSVWW---EHAGVRLP---THGRVY-QKGHELVLANIAESDAGVYTCHAANLA 397
Query: 558 DADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQ 617
ITV V ++ + + G+ L C + P ++ W N +L
Sbjct: 398 GQRRQDVNITVAT--VPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWY--RNQMLIS 453
Query: 618 SSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+V NGTLRI V D +YRC+++ P+G
Sbjct: 454 EDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAG 488
Score = 42.4 bits (98), Expect = 0.006
Identities = 41/184 (22%), Positives = 64/184 (34%), Gaps = 35/184 (19%)
Query: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCI 552
V L C G P P W DG+ + + + K L L+ A +G+Y C
Sbjct: 146 VTLRCHIDGHPRPTYQWF-RDGTPLSD---GQSNHTVSSKERNLTLRPAGPEHSGLYSCC 201
Query: 553 ----------SSNYD----DADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHST 598
S N+ D + + +V Y+E H C +
Sbjct: 202 AHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFH------------CQFS 249
Query: 599 GIPDASISWVIPGNNVLYQSSRDKK-----VLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
P S+ W+ + SR V NG+L + QV P++ G YRC+ G
Sbjct: 250 AQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP 309
Query: 654 DFLI 657
++
Sbjct: 310 PIIL 313
Score = 36.2 bits (82), Expect = 0.44
Identities = 24/70 (34%), Positives = 33/70 (47%), Gaps = 3/70 (4%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
TV G T L C QGDP P + W D ++ P R+ I ++G L + D
Sbjct: 602 TVYQGHTALLQCEAQGDPKPLIQWKGKD--RILDP-TKLGPRMHIFQNGSLVIHDVAPED 658
Query: 546 TGVYHCISSN 555
+G Y CI+ N
Sbjct: 659 SGRYTCIAGN 668
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 162 bits (411), Expect = 3e-39
Identities = 166/625 (26%), Positives = 269/625 (43%), Gaps = 58/625 (9%)
Query: 1831 LLVKI-QVIAAPPVILEQ--RRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPL 1887
LL++I + + PPVI EQ RR V+ T + + L C A G P+ W DG KP
Sbjct: 18 LLIQIPEELMEPPVITEQSPRRLVVFPT--DDISLKCEASGKPEVQFRWT-RDGVHFKPK 74
Query: 1888 QFTNSKLFLFSNGTLYI-----RNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR 1942
+ ++ + + N A +G Y C A++ G+ + M E +P+
Sbjct: 75 EELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEG--APK 132
Query: 1943 IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAV-VDQQHRVGSWIHVYPNGSL 2001
+ K EV G+ ++L C+ +P ++ + SK + + Q RV + NG+L
Sbjct: 133 WPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT----MGQNGNL 188
Query: 2002 FIGSVTEKDS-GVYLCVARNKMGDDLILMH-VSLRLKPAK--IDHKQYF--------RKQ 2049
+ +V D+ Y+C A +I + LR+K ID K
Sbjct: 189 YFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLV 248
Query: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKV 2109
L G+ ++C A G P P I W P G M AD ++ +N TL KV
Sbjct: 249 ALQGQPLVLECIAEGFPTPTIKWLRPSGPM-----PADRVTYQN------HNKTLQLLKV 297
Query: 2110 GVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDP 2169
G ++G+Y C A+N+LG ++TV AAP +++ G+TA LDC+V G P
Sbjct: 298 GEEDDGEYRCLAENSLGSARHAYYVTV-EAAPYWLHKPQSHL-YGPGETARLDCQVQGRP 355
Query: 2170 KPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLD 2229
+P++ W + + + D+ G+L ++ V+ D+ C ARN G +
Sbjct: 356 QPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIY 415
Query: 2230 VVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
VV P I N+T + AV+ S + C+A G P P V W+ D T R
Sbjct: 416 VVQLPAKILTA-DNQTYM---AVQGSTAYLLCKAFGAPVPSVQWLDEDG---TTVLQDER 468
Query: 2290 ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVA 2349
+ NGTL IR+++ +D+ + C+A N+ ++ L+V + + + P +
Sbjct: 469 FFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ--ITQGP--RSTIE 524
Query: 2350 QLGKSTALNC--SVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG 2407
+ G C S D + P I W +G S +Y I +G +I D G
Sbjct: 525 KKGSRVTFTCQASFDPSLQPSITW-RGDGRDLQELGDSDKYFI-EDGRLVIHSLDYSDQG 582
Query: 2408 KYRCAARNKVGYIEKLVILEIGQKP 2432
Y C A ++ +E L + P
Sbjct: 583 NYSCVASTELDVVESRAQLLVVGSP 607
Score = 153 bits (387), Expect = 2e-36
Identities = 148/601 (24%), Positives = 246/601 (40%), Gaps = 59/601 (9%)
Query: 2035 LKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSL------PDGTMINNAMQADD 2088
++P I + R V D + C+ASG P + W+ P + Q+
Sbjct: 27 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPH 86
Query: 2089 SGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNK 2148
SG +T+ N + + + +G Y C+A N LG + AP+ +
Sbjct: 87 SGS----FTITGNNSNFAQRF----QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETV 138
Query: 2149 TNKRIKAGDTAVLDCEVTGDPKP-KIFWLLPSNDMISFSID-RYTFHANGSLTINKVKLL 2206
++ G++ VL C +P +I+W+ ++ ++ D R T NG+L V
Sbjct: 139 KPVEVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQDERVTMGQNGNLYFANVLTS 196
Query: 2207 DS-GEYVCVARNPSGDDTKMYKLDVVSKPPLING--------LYTNRTVIKATAVRHSKK 2257
D+ +Y+C A P G T + K + + N L+ + A++
Sbjct: 197 DNHSDYICHAHFP-GTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPL 255
Query: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK-NGTLEIRNVRLSDSADFICVAR 2316
+C AEG P+P + W+ P + P R+T N TL++ V D ++ C+A
Sbjct: 256 VLECIAEGFPTPTIKWLRP-----SGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 310
Query: 2317 NEGGES--VLVVQLEVLEM-LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N G + V +E L +P + + G++ L+C V G P PE+ W +
Sbjct: 311 NSLGSARHAYYVTVEAAPYWLHKP-------QSHLYGPGETARLDCQVQGRPQPEVTWRI 363
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
NG + +Y I G+ I+S D +C ARN+ G + + + Q P
Sbjct: 364 -NGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPA 421
Query: 2434 -ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLV 2492
ILT T + G + L C + G P P+++W G V + + ++ + NGTL
Sbjct: 422 KILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE---RFFPYANGTLG 478
Query: 2493 IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVA 2552
I++ A D G Y C A N + +T+ + + PRS + + G+ C A
Sbjct: 479 IRDLQANDTGRYFCLAANDQNN--VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQA 536
Query: 2553 LGVP--KPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNP 2610
P +P ITW L ++ + G LVI + SD G Y C A
Sbjct: 537 SFDPSLQPSITWRGDGRDLQELGDSDKYFIED-----GRLVIHSLDYSDQGNYSCVASTE 591
Query: 2611 L 2611
L
Sbjct: 592 L 592
Score = 152 bits (384), Expect = 4e-36
Identities = 155/621 (24%), Positives = 242/621 (38%), Gaps = 69/621 (11%)
Query: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR--------VPSGLDLSKRK 1695
+ E P I + D L CEA G P WTR G+ + +
Sbjct: 26 LMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 85
Query: 1696 QNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEI 1755
+ + N + QR + G Y C ASN GT H + P+ + K +
Sbjct: 86 HSGSFTITGNNSNFAQRFQ----GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPV 141
Query: 1756 TVHSGSTVELKCRAEGRPSPT-VTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYD 1814
V G +V L C P + W+ + + + + + +G L N+ D
Sbjct: 142 EVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDER----VTMGQNGNLYFANVLTSD 197
Query: 1815 R-GFYKCVASNPGGQDSLL---VKIQVIAAPPVILEQRRQV--------IVGTWGESLKL 1862
Y C A PG + + + ++V A +I + R + +V G+ L L
Sbjct: 198 NHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 257
Query: 1863 PCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSS 1922
C A+G P P++ W+ G P+ + + N TL + + D G Y C+A +S
Sbjct: 258 ECIAEGFPTPTIKWLRPSG----PMP-ADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 312
Query: 1923 TGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAV 1982
GS R +T+E +P Q G+ L+C G P+P++ WR+ V
Sbjct: 313 LGSARHAYYVTVE---AAPYWLHKPQSHL-YGPGETARLDCQVQGRPQPEVTWRINGIPV 368
Query: 1983 V----DQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA 2038
DQ++R+ G+L + +V D+ V C ARN+ G L ++ + PA
Sbjct: 369 EELAKDQKYRI-------QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPA 421
Query: 2039 KI---DHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRR 2095
KI D++ Y Q G + CKA G+PVP + W DGT + + R
Sbjct: 422 KILTADNQTYMAVQ---GSTAYLLCKAFGAPVPSVQWLDEDGTTV----------LQDER 468
Query: 2096 YTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKA 2155
+ + NGTL + + G Y C A N + +L V A + T + K
Sbjct: 469 FFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIE--KK 526
Query: 2156 GDTAVLDCEVTGDP--KPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVC 2213
G C+ + DP +P I W D+ F +G L I+ + D G Y C
Sbjct: 527 GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSC 586
Query: 2214 VARNPSGDDTKMYKLDVVSKP 2234
VA +L VV P
Sbjct: 587 VASTELDVVESRAQLLVVGSP 607
Score = 146 bits (369), Expect = 2e-34
Identities = 153/598 (25%), Positives = 250/598 (41%), Gaps = 58/598 (9%)
Query: 1744 PPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSR--QAVVTV 1801
PP I E+ + + V + LKC A G+P W + G Q+ +
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88
Query: 1802 DGTLVLHNLSIYDR--GFYKCVASNP-GGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGE 1858
T+ +N + R G Y+C ASN G S +++ AP E + V V GE
Sbjct: 89 SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE-GE 147
Query: 1859 SLKLPCTAKGTPQP-SVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYEC 1917
S+ LPC + +P +YW+ S +K + ++ + NG LY N+ +SD + +
Sbjct: 148 SVVLPCNPPPSAEPLRIYWMNSKILHIKQ----DERVTMGQNGNLYFANVLTSDNHS-DY 202
Query: 1918 IATSSTGSERRVVM---LTMEERVTSPRIEAASQKRTEVNF--------GDKLLLNCSAT 1966
I + R ++ + + + T+ I+ + N G L+L C A
Sbjct: 203 ICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAE 262
Query: 1967 GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDL 2026
G P P I W PS + RV H N +L + V E+D G Y C+A N +G
Sbjct: 263 GFPTPTIKWLRPSGPM--PADRVTYQNH---NKTLQLLKVGEEDDGEYRCLAENSLGSAR 317
Query: 2027 ILMHVSLRLKPAKIDHKQYFRKQVLH----GKDFQVDCKASGSPVPEISWSLPDGTMINN 2082
+V++ P + K H G+ ++DC+ G P PE++W + +G +
Sbjct: 318 HAYYVTVEAAP------YWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRI-NGIPVEE 370
Query: 2083 AMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPR 2142
A D +R +R G L + V ++ C A+N G ++ V+ +
Sbjct: 371 L--AKDQKYRIQR------GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 422
Query: 2143 IRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINK 2202
I ++ G TA L C+ G P P + WL + +R+ +ANG+L I
Sbjct: 423 ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV-LQDERFFPYANGTLGIRD 481
Query: 2203 VKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCR 2262
++ D+G Y C+A N + T M L V + G T+ K + S+ F C+
Sbjct: 482 LQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQG--PRSTIEK----KGSRVTFTCQ 535
Query: 2263 AEGTPS--PEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
A PS P + W D L + + ++G L I ++ SD ++ CVA E
Sbjct: 536 ASFDPSLQPSITW-RGDGRDLQELGDSDKYFI-EDGRLVIHSLDYSDQGNYSCVASTE 591
Score = 144 bits (362), Expect = 1e-33
Identities = 157/615 (25%), Positives = 258/615 (41%), Gaps = 53/615 (8%)
Query: 1935 EERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIH 1994
EE + P I S +R V D + L C A+G+P+ Q W ++ +G ++
Sbjct: 24 EELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEE-LGVTVY 82
Query: 1995 VYPNGSLFI-----GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK- 2048
P+ F + ++ G+Y C A NK+G + + L + A K+ +
Sbjct: 83 QSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMS-HEIRLMAEGAPKWPKETVKPV 141
Query: 2049 QVLHGKDFQVDCKASGSPVP-EISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFN 2107
+V G+ + C S P I W + I + Q + R T+ NG LYF
Sbjct: 142 EVEEGESVVLPCNPPPSAEPLRIYWM---NSKILHIKQDE-------RVTMGQNGNLYFA 191
Query: 2108 KVGVAEE-GDYTCYAQ----NTLGKDE-----MKVHLTVITAAPRIRQSNKTNKRIKA-- 2155
V ++ DY C+A T+ + E +K ++I PR+ ++ + A
Sbjct: 192 NVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ 251
Query: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTF-HANGSLTINKVKLLDSGEYVCV 2214
G VL+C G P P I WL PS M + DR T+ + N +L + KV D GEY C+
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSGPMPA---DRVTYQNHNKTLQLLKVGEEDDGEYRCL 308
Query: 2215 ARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWI 2274
A N G Y + V + P ++ ++ TA DC+ +G P PEV W
Sbjct: 309 AENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETA------RLDCQVQGRPQPEVTWR 362
Query: 2275 MPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEML 2334
+ + I + + + + G L + NV+ SD+ C ARN G + + V+++
Sbjct: 363 I-NGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 420
Query: 2335 RRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG 2394
+ + N+ +A G + L C G P P + W+ +GT + + Y +NG
Sbjct: 421 AKILTAD--NQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPY---ANG 475
Query: 2395 SFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC 2454
+ I D G+Y C A N + + L++ I T P + G ++ C
Sbjct: 476 TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQI-TQGPRSTIEKKGSRVTFTC 534
Query: 2455 VSDGIP--KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSV 2512
+ P +P+I W G + + KY + D G LVI D+GNY C A +
Sbjct: 535 QASFDPSLQPSITWR-GDGRDLQELGDSDKYFIED-GRLVIHSLDYSDQGNYSCVASTEL 592
Query: 2513 GHTLITVPVMIVAYP 2527
+++V P
Sbjct: 593 DVVESRAQLLVVGSP 607
Score = 92.0 bits (227), Expect = 7e-18
Identities = 105/417 (25%), Positives = 168/417 (40%), Gaps = 53/417 (12%)
Query: 2233 KPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITV 2292
+PP+I R V+ T K C A G P + W F G +TV
Sbjct: 28 EPPVITEQSPRRLVVFPTDDISLK----CEASGKPEVQFRWTRDGVHFKPKEELG--VTV 81
Query: 2293 HKN---GTLEIR----NVRLSDSADFICVARNEGGESVLVVQLEVLEMLR-RPTFRNPFN 2344
+++ G+ I N + C A N+ G ++ E+ M P +
Sbjct: 82 YQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAM---SHEIRLMAEGAPKWPKETV 138
Query: 2345 EKIVAQLGKSTALNCSVDGNPPPE-----IIWILPNGTRFSNGPQSYQYLIASNGSFIIS 2399
+ + + G+S L C NPPP I W+ ++ + Q + + NG+ +
Sbjct: 139 KPVEVEEGESVVLPC----NPPPSAEPLRIYWM---NSKILHIKQDERVTMGQNGNLYFA 191
Query: 2400 KT-TREDAGKYRCAA----------RNKVGYIEKLVILEIGQKPVIL--TYAPGTVKGIS 2446
T ++ Y C A + + K I +KP +L T + + +
Sbjct: 192 NVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ 251
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYIC 2506
G+ L L C+++G P P IKW PSG P Y H N TL + + D G Y C
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNH-NKTLQLLKVGEEDDGEYRC 307
Query: 2507 KAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPD 2566
A+NS+G V + A P + P+S + G +L C G P+PE+TW +
Sbjct: 308 LAENSLGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRING 365
Query: 2567 HSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ A ++ +G L++ N Q SD+ + +C A+N G A YI V+
Sbjct: 366 IPVEELAKDQKYRIQ-----RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 417
Score = 58.2 bits (139), Expect = 1e-07
Identities = 58/231 (25%), Positives = 97/231 (41%), Gaps = 14/231 (6%)
Query: 421 DLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNN 480
+L D + +Q + N + Q + + + L A + V+ +++ DN
Sbjct: 370 ELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQ 429
Query: 481 TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM 540
T + + G T L C G P P V WL DG+ V +D R +G L ++
Sbjct: 430 T---YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-----QDERFFPYANGTLGIRD 481
Query: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI-GETLDLPCHSTG 599
+ DTG Y C+++N D ++ V+ + Q G T+ G + C ++
Sbjct: 482 LQANDTGRYFCLAAN-DQNNVTIMANLKVKDATQITQ--GPRSTIEKKGSRVTFTCQASF 538
Query: 600 IPDA--SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAA 648
P SI+W G ++ DK + +G L I + DQG Y CVA+
Sbjct: 539 DPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVAS 589
Score = 55.5 bits (132), Expect = 7e-07
Identities = 47/174 (27%), Positives = 71/174 (40%), Gaps = 5/174 (2%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G T L+C QG P P V W + + + +++D + I + G L L DT V
Sbjct: 342 GETARLDCQVQGRPQPEVTWRI---NGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVT 397
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C + N + I VV+ + + + G T L C + G P S+ W+
Sbjct: 398 QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLD 457
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
+ Q R N GTL I + D G Y C+AAN ++ + VK
Sbjct: 458 EDGTTVLQDERFFPYAN-GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVK 510
Score = 55.1 bits (131), Expect = 9e-07
Identities = 47/175 (26%), Positives = 68/175 (38%), Gaps = 10/175 (5%)
Query: 480 NTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LEL 538
N+ L G + L C +G PTP + WL G P ++ R+ K L+L
Sbjct: 242 NSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSG-----PMPAD--RVTYQNHNKTLQL 294
Query: 539 QMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHST 598
D G Y C++ N + Y +TV ++ H GET L C
Sbjct: 295 LKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQS--HLYGPGETARLDCQVQ 352
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
G P ++W I G V + K + G L + V P D +C A N G+
Sbjct: 353 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGL 407
Score = 48.1 bits (113), Expect = 1e-04
Identities = 49/210 (23%), Positives = 89/210 (42%), Gaps = 34/210 (16%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G +V L C +P P + L + ++ +D R+ + ++G L + D
Sbjct: 146 GESVVLPC----NPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD 201
Query: 550 HCISSNYDDA------DILTYRITVVEPLVEA-----YQENGIHHTVFI-GETLDLPCHS 597
+ +++ + + R+ +++ + N H V + G+ L L C +
Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA 261
Query: 598 TGIPDASISWV-----IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
G P +I W+ +P + V YQ+ +N TL++L+V +D G YRC+A N G
Sbjct: 262 EGFPTPTIKWLRPSGPMPADRVTYQN-------HNKTLQLLKVGEEDDGEYRCLAENSLG 314
Query: 653 VDFLIFQVSVKM------KGQRPLEHDGET 676
+ V+V+ K Q L GET
Sbjct: 315 SARHAYYVTVEAAPYWLHKPQSHLYGPGET 344
Score = 33.1 bits (74), Expect = 3.7
Identities = 42/195 (21%), Positives = 71/195 (36%), Gaps = 21/195 (10%)
Query: 2427 EIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPS---------GYVVDRP 2477
E+ + PVI +P + + +SL C + G P+ +WT G V +
Sbjct: 25 ELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQS 84
Query: 2478 QINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRS 2537
+G + + N + + +G Y C A N +G + ++ P+ +
Sbjct: 85 PHSGSFTITGNNSNFAQRF----QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKP 140
Query: 2538 IVTRTGAAFQLHCVALGVPKP-EITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQ 2596
+ G + L C +P I W + +L ER + G L N
Sbjct: 141 VEVEEGESVVLPCNPPPSAEPLRIYW--MNSKILHIKQDERV----TMGQNGNLYFANVL 194
Query: 2597 TSDS-GIYKCTAKNP 2610
TSD+ Y C A P
Sbjct: 195 TSDNHSDYICHAHFP 209
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 161 bits (408), Expect = 7e-39
Identities = 163/617 (26%), Positives = 263/617 (42%), Gaps = 57/617 (9%)
Query: 1838 IAAPPVILEQ--RRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLF 1895
+ PPVI EQ RR V+ T + + L C A G P+ W DG KP + ++
Sbjct: 31 VMEPPVITEQSPRRLVVFPT--DDISLKCEASGKPEVQFRWT-RDGVHFKPKEELGVTVY 87
Query: 1896 LFSNGTLYI-----RNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKR 1950
+ + N A +G Y C A++ G+ + M E +P+ + K
Sbjct: 88 QSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEG--APKWPKETVKP 145
Query: 1951 TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAV-VDQQHRVGSWIHVYPNGSLFIGSVTEK 2009
EV G+ ++L C+ +P ++ + SK + + Q RV + NG+L+ +V
Sbjct: 146 VEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT----MGQNGNLYFANVLTS 201
Query: 2010 DS-GVYLCVARNKMGDDLILMH-VSLRLKPAK--IDHKQYF--------RKQVLHGKDFQ 2057
D+ Y+C A +I + LR+K ID K L G+
Sbjct: 202 DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLV 261
Query: 2058 VDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDY 2117
++C A G P P I W P G M AD ++ +N TL KVG ++G+Y
Sbjct: 262 LECIAEGFPTPTIKWLRPSGPM-----PADRVTYQN------HNKTLQLLKVGEEDDGEY 310
Query: 2118 TCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL 2177
C A+N+LG ++TV AAP +++ G+TA LDC+V G P+P++ W +
Sbjct: 311 RCLAENSLGSARHAYYVTV-EAAPYWLHKPQSHL-YGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2178 PSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
+ + D+ G+L ++ V+ D+ C ARN G + VV P I
Sbjct: 369 NGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKI 428
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
N+T + AV+ S + C+A G P P V W+ D T R + NGT
Sbjct: 429 LTA-DNQTYM---AVQGSTAYLLCKAFGAPVPSVQWLDEDG---TTVLQDERFFPYANGT 481
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL 2357
L IR+++ +D+ + C+A N+ ++ L+V + + + P + + G
Sbjct: 482 LGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ--ITQGP--RSTIEKKGSRVTF 537
Query: 2358 NC--SVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARN 2415
C S D + P I W +G S +Y I +G +I D G Y C A
Sbjct: 538 TCQASFDPSLQPSITW-RGDGRDLQELGDSDKYFI-EDGRLVIHSLDYSDQGNYSCVAST 595
Query: 2416 KVGYIEKLVILEIGQKP 2432
++ +E L + P
Sbjct: 596 ELDVVESRAQLLVVGSP 612
Score = 154 bits (390), Expect = 8e-37
Identities = 156/630 (24%), Positives = 246/630 (39%), Gaps = 69/630 (10%)
Query: 1635 LPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR--------VP 1686
+P + ++ E P I + D L CEA G P WTR
Sbjct: 22 IPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEE 81
Query: 1687 SGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR 1746
G+ + + + + N + QR + G Y C ASN GT H + P+
Sbjct: 82 LGVTVYQSPHSGSFTITGNNSNFAQRFQ----GIYRCFASNKLGTAMSHEIRLMAEGAPK 137
Query: 1747 ILERRTKEITVHSGSTVELKCRAEGRPSPT-VTWILANQTVVSESSQGSRQAVVTVDGTL 1805
+ K + V G +V L C P + W+ + + + + + +G L
Sbjct: 138 WPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDER----VTMGQNGNL 193
Query: 1806 VLHNLSIYDR-GFYKCVASNPGGQDSLL---VKIQVIAAPPVILEQRRQV--------IV 1853
N+ D Y C A PG + + + ++V A +I + R + +V
Sbjct: 194 YFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLV 253
Query: 1854 GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
G+ L L C A+G P P++ W+ G P+ + + N TL + + D G
Sbjct: 254 ALQGQPLVLECIAEGFPTPTIKWLRPSG----PMP-ADRVTYQNHNKTLQLLKVGEEDDG 308
Query: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQI 1973
Y C+A +S GS R +T+E +P Q G+ L+C G P+P++
Sbjct: 309 EYRCLAENSLGSARHAYYVTVE---AAPYWLHKPQSHL-YGPGETARLDCQVQGRPQPEV 364
Query: 1974 MWRLPSKAVV----DQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILM 2029
WR+ V DQ++R+ G+L + +V D+ V C ARN+ G L
Sbjct: 365 TWRINGIPVEELAKDQKYRI-------QRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 2030 HVSLRLKPAKI---DHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQA 2086
++ + PAKI D++ Y Q G + CKA G+PVP + W DGT +
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQ---GSTAYLLCKAFGAPVPSVQWLDEDGTTV------ 468
Query: 2087 DDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQS 2146
+ R+ + NGTL + + G Y C A N + +L V A +
Sbjct: 469 ----LQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 524
Query: 2147 NKTNKRIKAGDTAVLDCEVTGDP--KPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVK 2204
T + K G C+ + DP +P I W D+ F +G L I+ +
Sbjct: 525 RSTIE--KKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLD 582
Query: 2205 LLDSGEYVCVARNPSGDDTKMYKLDVVSKP 2234
D G Y CVA +L VV P
Sbjct: 583 YSDQGNYSCVASTELDVVESRAQLLVVGSP 612
Score = 153 bits (387), Expect = 2e-36
Identities = 148/601 (24%), Positives = 246/601 (40%), Gaps = 59/601 (9%)
Query: 2035 LKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSL------PDGTMINNAMQADD 2088
++P I + R V D + C+ASG P + W+ P + Q+
Sbjct: 32 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPH 91
Query: 2089 SGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNK 2148
SG +T+ N + + + +G Y C+A N LG + AP+ +
Sbjct: 92 SGS----FTITGNNSNFAQRF----QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETV 143
Query: 2149 TNKRIKAGDTAVLDCEVTGDPKP-KIFWLLPSNDMISFSID-RYTFHANGSLTINKVKLL 2206
++ G++ VL C +P +I+W+ ++ ++ D R T NG+L V
Sbjct: 144 KPVEVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQDERVTMGQNGNLYFANVLTS 201
Query: 2207 DS-GEYVCVARNPSGDDTKMYKLDVVSKPPLING--------LYTNRTVIKATAVRHSKK 2257
D+ +Y+C A P G T + K + + N L+ + A++
Sbjct: 202 DNHSDYICHAHFP-GTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPL 260
Query: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK-NGTLEIRNVRLSDSADFICVAR 2316
+C AEG P+P + W+ P + P R+T N TL++ V D ++ C+A
Sbjct: 261 VLECIAEGFPTPTIKWLRP-----SGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 315
Query: 2317 NEGGES--VLVVQLEVLEM-LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N G + V +E L +P + + G++ L+C V G P PE+ W +
Sbjct: 316 NSLGSARHAYYVTVEAAPYWLHKP-------QSHLYGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
NG + +Y I G+ I+S D +C ARN+ G + + + Q P
Sbjct: 369 -NGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPA 426
Query: 2434 -ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLV 2492
ILT T + G + L C + G P P+++W G V + + ++ + NGTL
Sbjct: 427 KILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE---RFFPYANGTLG 483
Query: 2493 IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVA 2552
I++ A D G Y C A N + +T+ + + PRS + + G+ C A
Sbjct: 484 IRDLQANDTGRYFCLAANDQNN--VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQA 541
Query: 2553 LGVP--KPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNP 2610
P +P ITW L ++ + G LVI + SD G Y C A
Sbjct: 542 SFDPSLQPSITWRGDGRDLQELGDSDKYFIED-----GRLVIHSLDYSDQGNYSCVASTE 596
Query: 2611 L 2611
L
Sbjct: 597 L 597
Score = 147 bits (370), Expect = 2e-34
Identities = 154/601 (25%), Positives = 251/601 (41%), Gaps = 58/601 (9%)
Query: 1741 VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSR--QAV 1798
V PP I E+ + + V + LKC A G+P W + G Q+
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 1799 VTVDGTLVLHNLSIYDR--GFYKCVASNP-GGQDSLLVKIQVIAAPPVILEQRRQVIVGT 1855
+ T+ +N + R G Y+C ASN G S +++ AP E + V V
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 1856 WGESLKLPCTAKGTPQP-SVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGT 1914
GES+ LPC + +P +YW+ S +K + ++ + NG LY N+ +SD +
Sbjct: 151 -GESVVLPCNPPPSAEPLRIYWMNSKILHIKQ----DERVTMGQNGNLYFANVLTSDNHS 205
Query: 1915 YECIATSSTGSERRVVM---LTMEERVTSPRIEAASQKRTEVNF--------GDKLLLNC 1963
+ I + R ++ + + + T+ I+ + N G L+L C
Sbjct: 206 -DYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLEC 264
Query: 1964 SATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
A G P P I W PS + RV H N +L + V E+D G Y C+A N +G
Sbjct: 265 IAEGFPTPTIKWLRPSGPM--PADRVTYQNH---NKTLQLLKVGEEDDGEYRCLAENSLG 319
Query: 2024 DDLILMHVSLRLKPAKIDHKQYFRKQVLH----GKDFQVDCKASGSPVPEISWSLPDGTM 2079
+V++ P + K H G+ ++DC+ G P PE++W + +G
Sbjct: 320 SARHAYYVTVEAAP------YWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRI-NGIP 372
Query: 2080 INNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA 2139
+ A D +R +R G L + V ++ C A+N G ++ V+
Sbjct: 373 VEEL--AKDQKYRIQR------GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL 424
Query: 2140 APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLT 2199
+I ++ G TA L C+ G P P + WL + +R+ +ANG+L
Sbjct: 425 PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV-LQDERFFPYANGTLG 483
Query: 2200 INKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHF 2259
I ++ D+G Y C+A N + T M L V + G T+ K + S+ F
Sbjct: 484 IRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQG--PRSTIEK----KGSRVTF 537
Query: 2260 DCRAEGTPS--PEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317
C+A PS P + W D L + + ++G L I ++ SD ++ CVA
Sbjct: 538 TCQASFDPSLQPSITW-RGDGRDLQELGDSDKYFI-EDGRLVIHSLDYSDQGNYSCVAST 595
Query: 2318 E 2318
E
Sbjct: 596 E 596
Score = 141 bits (355), Expect = 1e-32
Identities = 155/609 (25%), Positives = 255/609 (41%), Gaps = 53/609 (8%)
Query: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS 2000
P I S +R V D + L C A+G+P+ Q W ++ +G ++ P+
Sbjct: 35 PVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEE-LGVTVYQSPHSG 93
Query: 2001 LFI-----GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK-QVLHGK 2054
F + ++ G+Y C A NK+G + + L + A K+ + +V G+
Sbjct: 94 SFTITGNNSNFAQRFQGIYRCFASNKLGTAMS-HEIRLMAEGAPKWPKETVKPVEVEEGE 152
Query: 2055 DFQVDCKASGSPVP-EISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
+ C S P I W + I + Q + R T+ NG LYF V ++
Sbjct: 153 SVVLPCNPPPSAEPLRIYWM---NSKILHIKQDE-------RVTMGQNGNLYFANVLTSD 202
Query: 2114 E-GDYTCYAQ----NTLGKDE-----MKVHLTVITAAPRIRQSNKTNKRIKA--GDTAVL 2161
DY C+A T+ + E +K ++I PR+ ++ + A G VL
Sbjct: 203 NHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 262
Query: 2162 DCEVTGDPKPKIFWLLPSNDMISFSIDRYTF-HANGSLTINKVKLLDSGEYVCVARNPSG 2220
+C G P P I WL PS M + DR T+ + N +L + KV D GEY C+A N G
Sbjct: 263 ECIAEGFPTPTIKWLRPSGPMPA---DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLG 319
Query: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
Y + V + P ++ ++ TA DC+ +G P PEV W + + I
Sbjct: 320 SARHAYYVTVEAAPYWLHKPQSHLYGPGETA------RLDCQVQGRPQPEVTWRI-NGIP 372
Query: 2281 LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
+ + + + G L + NV+ SD+ C ARN G + + V+++ +
Sbjct: 373 VEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTA 431
Query: 2341 NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
+ N+ +A G + L C G P P + W+ +GT + + Y +NG+ I
Sbjct: 432 D--NQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPY---ANGTLGIRD 486
Query: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIP 2460
D G+Y C A N + + L++ I T P + G ++ C + P
Sbjct: 487 LQANDTGRYFCLAANDQNNVTIMANLKVKDATQI-TQGPRSTIEKKGSRVTFTCQASFDP 545
Query: 2461 --KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLIT 2518
+P+I W G + + KY + D G LVI D+GNY C A +
Sbjct: 546 SLQPSITWR-GDGRDLQELGDSDKYFIED-GRLVIHSLDYSDQGNYSCVASTELDVVESR 603
Query: 2519 VPVMIVAYP 2527
+++V P
Sbjct: 604 AQLLVVGSP 612
Score = 93.2 bits (230), Expect = 3e-18
Identities = 106/419 (25%), Positives = 169/419 (40%), Gaps = 53/419 (12%)
Query: 2231 VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRI 2290
V +PP+I R V+ T K C A G P + W F G +
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLK----CEASGKPEVQFRWTRDGVHFKPKEELG--V 84
Query: 2291 TVHKN---GTLEIR----NVRLSDSADFICVARNEGGESVLVVQLEVLEMLR-RPTFRNP 2342
TV+++ G+ I N + C A N+ G ++ E+ M P +
Sbjct: 85 TVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAM---SHEIRLMAEGAPKWPKE 141
Query: 2343 FNEKIVAQLGKSTALNCSVDGNPPPE-----IIWILPNGTRFSNGPQSYQYLIASNGSFI 2397
+ + + G+S L C NPPP I W+ ++ + Q + + NG+
Sbjct: 142 TVKPVEVEEGESVVLPC----NPPPSAEPLRIYWM---NSKILHIKQDERVTMGQNGNLY 194
Query: 2398 ISKT-TREDAGKYRCAA----------RNKVGYIEKLVILEIGQKPVIL--TYAPGTVKG 2444
+ T ++ Y C A + + K I +KP +L T + +
Sbjct: 195 FANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVA 254
Query: 2445 ISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNY 2504
+ G+ L L C+++G P P IKW PSG P Y H N TL + + D G Y
Sbjct: 255 LQGQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNH-NKTLQLLKVGEEDDGEY 310
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
C A+NS+G V + A P + P+S + G +L C G P+PE+TW +
Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2565 PDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ A ++ +G L++ N Q SD+ + +C A+N G A YI V+
Sbjct: 369 NGIPVEELAKDQKYRIQ-----RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 422
Score = 58.2 bits (139), Expect = 1e-07
Identities = 58/231 (25%), Positives = 97/231 (41%), Gaps = 14/231 (6%)
Query: 421 DLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNN 480
+L D + +Q + N + Q + + + L A + V+ +++ DN
Sbjct: 375 ELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQ 434
Query: 481 TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM 540
T + + G T L C G P P V WL DG+ V +D R +G L ++
Sbjct: 435 T---YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-----QDERFFPYANGTLGIRD 486
Query: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI-GETLDLPCHSTG 599
+ DTG Y C+++N D ++ V+ + Q G T+ G + C ++
Sbjct: 487 LQANDTGRYFCLAAN-DQNNVTIMANLKVKDATQITQ--GPRSTIEKKGSRVTFTCQASF 543
Query: 600 IPDA--SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAA 648
P SI+W G ++ DK + +G L I + DQG Y CVA+
Sbjct: 544 DPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVAS 594
Score = 55.5 bits (132), Expect = 7e-07
Identities = 47/174 (27%), Positives = 71/174 (40%), Gaps = 5/174 (2%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G T L+C QG P P V W + + + +++D + I + G L L DT V
Sbjct: 347 GETARLDCQVQGRPQPEVTWRI---NGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVT 402
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C + N + I VV+ + + + G T L C + G P S+ W+
Sbjct: 403 QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLD 462
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
+ Q R N GTL I + D G Y C+AAN ++ + VK
Sbjct: 463 EDGTTVLQDERFFPYAN-GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVK 515
Score = 55.1 bits (131), Expect = 9e-07
Identities = 47/175 (26%), Positives = 68/175 (38%), Gaps = 10/175 (5%)
Query: 480 NTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LEL 538
N+ L G + L C +G PTP + WL G P ++ R+ K L+L
Sbjct: 247 NSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSG-----PMPAD--RVTYQNHNKTLQL 299
Query: 539 QMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHST 598
D G Y C++ N + Y +TV ++ H GET L C
Sbjct: 300 LKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQS--HLYGPGETARLDCQVQ 357
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
G P ++W I G V + K + G L + V P D +C A N G+
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGL 412
Score = 48.1 bits (113), Expect = 1e-04
Identities = 49/210 (23%), Positives = 89/210 (42%), Gaps = 34/210 (16%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G +V L C +P P + L + ++ +D R+ + ++G L + D
Sbjct: 151 GESVVLPC----NPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD 206
Query: 550 HCISSNYDDA------DILTYRITVVEPLVEA-----YQENGIHHTVFI-GETLDLPCHS 597
+ +++ + + R+ +++ + N H V + G+ L L C +
Sbjct: 207 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA 266
Query: 598 TGIPDASISWV-----IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
G P +I W+ +P + V YQ+ +N TL++L+V +D G YRC+A N G
Sbjct: 267 EGFPTPTIKWLRPSGPMPADRVTYQN-------HNKTLQLLKVGEEDDGEYRCLAENSLG 319
Query: 653 VDFLIFQVSVKM------KGQRPLEHDGET 676
+ V+V+ K Q L GET
Sbjct: 320 SARHAYYVTVEAAPYWLHKPQSHLYGPGET 349
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 161 bits (408), Expect = 7e-39
Identities = 163/617 (26%), Positives = 263/617 (42%), Gaps = 57/617 (9%)
Query: 1838 IAAPPVILEQ--RRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLF 1895
+ PPVI EQ RR V+ T + + L C A G P+ W DG KP + ++
Sbjct: 31 VMEPPVITEQSPRRLVVFPT--DDISLKCEASGKPEVQFRWT-RDGVHFKPKEELGVTVY 87
Query: 1896 LFSNGTLYI-----RNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKR 1950
+ + N A +G Y C A++ G+ + M E +P+ + K
Sbjct: 88 QSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEG--APKWPKETVKP 145
Query: 1951 TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAV-VDQQHRVGSWIHVYPNGSLFIGSVTEK 2009
EV G+ ++L C+ +P ++ + SK + + Q RV + NG+L+ +V
Sbjct: 146 VEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT----MGQNGNLYFANVLTS 201
Query: 2010 DS-GVYLCVARNKMGDDLILMH-VSLRLKPAK--IDHKQYF--------RKQVLHGKDFQ 2057
D+ Y+C A +I + LR+K ID K L G+
Sbjct: 202 DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLV 261
Query: 2058 VDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDY 2117
++C A G P P I W P G M AD ++ +N TL KVG ++G+Y
Sbjct: 262 LECIAEGFPTPTIKWLRPSGPM-----PADRVTYQN------HNKTLQLLKVGEEDDGEY 310
Query: 2118 TCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL 2177
C A+N+LG ++TV AAP +++ G+TA LDC+V G P+P++ W +
Sbjct: 311 RCLAENSLGSARHAYYVTV-EAAPYWLHKPQSHL-YGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2178 PSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
+ + D+ G+L ++ V+ D+ C ARN G + VV P I
Sbjct: 369 NGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKI 428
Query: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT 2297
N+T + AV+ S + C+A G P P V W+ D T R + NGT
Sbjct: 429 LTA-DNQTYM---AVQGSTAYLLCKAFGAPVPSVQWLDEDG---TTVLQDERFFPYANGT 481
Query: 2298 LEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL 2357
L IR+++ +D+ + C+A N+ ++ L+V + + + P + + G
Sbjct: 482 LGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ--ITQGP--RSTIEKKGSRVTF 537
Query: 2358 NC--SVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARN 2415
C S D + P I W +G S +Y I +G +I D G Y C A
Sbjct: 538 TCQASFDPSLQPSITW-RGDGRDLQELGDSDKYFI-EDGRLVIHSLDYSDQGNYSCVAST 595
Query: 2416 KVGYIEKLVILEIGQKP 2432
++ +E L + P
Sbjct: 596 ELDVVESRAQLLVVGSP 612
Score = 154 bits (390), Expect = 8e-37
Identities = 156/630 (24%), Positives = 246/630 (39%), Gaps = 69/630 (10%)
Query: 1635 LPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR--------VP 1686
+P + ++ E P I + D L CEA G P WTR
Sbjct: 22 IPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEE 81
Query: 1687 SGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR 1746
G+ + + + + N + QR + G Y C ASN GT H + P+
Sbjct: 82 LGVTVYQSPHSGSFTITGNNSNFAQRFQ----GIYRCFASNKLGTAMSHEIRLMAEGAPK 137
Query: 1747 ILERRTKEITVHSGSTVELKCRAEGRPSPT-VTWILANQTVVSESSQGSRQAVVTVDGTL 1805
+ K + V G +V L C P + W+ + + + + + +G L
Sbjct: 138 WPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDER----VTMGQNGNL 193
Query: 1806 VLHNLSIYDR-GFYKCVASNPGGQDSLL---VKIQVIAAPPVILEQRRQV--------IV 1853
N+ D Y C A PG + + + ++V A +I + R + +V
Sbjct: 194 YFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLV 253
Query: 1854 GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
G+ L L C A+G P P++ W+ G P+ + + N TL + + D G
Sbjct: 254 ALQGQPLVLECIAEGFPTPTIKWLRPSG----PMP-ADRVTYQNHNKTLQLLKVGEEDDG 308
Query: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQI 1973
Y C+A +S GS R +T+E +P Q G+ L+C G P+P++
Sbjct: 309 EYRCLAENSLGSARHAYYVTVE---AAPYWLHKPQSHL-YGPGETARLDCQVQGRPQPEV 364
Query: 1974 MWRLPSKAVV----DQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILM 2029
WR+ V DQ++R+ G+L + +V D+ V C ARN+ G L
Sbjct: 365 TWRINGIPVEELAKDQKYRI-------QRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 2030 HVSLRLKPAKI---DHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQA 2086
++ + PAKI D++ Y Q G + CKA G+PVP + W DGT +
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQ---GSTAYLLCKAFGAPVPSVQWLDEDGTTV------ 468
Query: 2087 DDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQS 2146
+ R+ + NGTL + + G Y C A N + +L V A +
Sbjct: 469 ----LQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 524
Query: 2147 NKTNKRIKAGDTAVLDCEVTGDP--KPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVK 2204
T + K G C+ + DP +P I W D+ F +G L I+ +
Sbjct: 525 RSTIE--KKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLD 582
Query: 2205 LLDSGEYVCVARNPSGDDTKMYKLDVVSKP 2234
D G Y CVA +L VV P
Sbjct: 583 YSDQGNYSCVASTELDVVESRAQLLVVGSP 612
Score = 153 bits (387), Expect = 2e-36
Identities = 148/601 (24%), Positives = 246/601 (40%), Gaps = 59/601 (9%)
Query: 2035 LKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSL------PDGTMINNAMQADD 2088
++P I + R V D + C+ASG P + W+ P + Q+
Sbjct: 32 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPH 91
Query: 2089 SGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNK 2148
SG +T+ N + + + +G Y C+A N LG + AP+ +
Sbjct: 92 SGS----FTITGNNSNFAQRF----QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETV 143
Query: 2149 TNKRIKAGDTAVLDCEVTGDPKP-KIFWLLPSNDMISFSID-RYTFHANGSLTINKVKLL 2206
++ G++ VL C +P +I+W+ ++ ++ D R T NG+L V
Sbjct: 144 KPVEVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQDERVTMGQNGNLYFANVLTS 201
Query: 2207 DS-GEYVCVARNPSGDDTKMYKLDVVSKPPLING--------LYTNRTVIKATAVRHSKK 2257
D+ +Y+C A P G T + K + + N L+ + A++
Sbjct: 202 DNHSDYICHAHFP-GTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPL 260
Query: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHK-NGTLEIRNVRLSDSADFICVAR 2316
+C AEG P+P + W+ P + P R+T N TL++ V D ++ C+A
Sbjct: 261 VLECIAEGFPTPTIKWLRP-----SGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 315
Query: 2317 NEGGES--VLVVQLEVLEM-LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL 2373
N G + V +E L +P + + G++ L+C V G P PE+ W +
Sbjct: 316 NSLGSARHAYYVTVEAAPYWLHKP-------QSHLYGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2374 PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
NG + +Y I G+ I+S D +C ARN+ G + + + Q P
Sbjct: 369 -NGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPA 426
Query: 2434 -ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLV 2492
ILT T + G + L C + G P P+++W G V + + ++ + NGTL
Sbjct: 427 KILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE---RFFPYANGTLG 483
Query: 2493 IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVA 2552
I++ A D G Y C A N + +T+ + + PRS + + G+ C A
Sbjct: 484 IRDLQANDTGRYFCLAANDQNN--VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQA 541
Query: 2553 LGVP--KPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNP 2610
P +P ITW L ++ + G LVI + SD G Y C A
Sbjct: 542 SFDPSLQPSITWRGDGRDLQELGDSDKYFIED-----GRLVIHSLDYSDQGNYSCVASTE 596
Query: 2611 L 2611
L
Sbjct: 597 L 597
Score = 147 bits (370), Expect = 2e-34
Identities = 154/601 (25%), Positives = 251/601 (41%), Gaps = 58/601 (9%)
Query: 1741 VSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSR--QAV 1798
V PP I E+ + + V + LKC A G+P W + G Q+
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 1799 VTVDGTLVLHNLSIYDR--GFYKCVASNP-GGQDSLLVKIQVIAAPPVILEQRRQVIVGT 1855
+ T+ +N + R G Y+C ASN G S +++ AP E + V V
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 1856 WGESLKLPCTAKGTPQP-SVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGT 1914
GES+ LPC + +P +YW+ S +K + ++ + NG LY N+ +SD +
Sbjct: 151 -GESVVLPCNPPPSAEPLRIYWMNSKILHIKQ----DERVTMGQNGNLYFANVLTSDNHS 205
Query: 1915 YECIATSSTGSERRVVM---LTMEERVTSPRIEAASQKRTEVNF--------GDKLLLNC 1963
+ I + R ++ + + + T+ I+ + N G L+L C
Sbjct: 206 -DYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLEC 264
Query: 1964 SATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
A G P P I W PS + RV H N +L + V E+D G Y C+A N +G
Sbjct: 265 IAEGFPTPTIKWLRPSGPM--PADRVTYQNH---NKTLQLLKVGEEDDGEYRCLAENSLG 319
Query: 2024 DDLILMHVSLRLKPAKIDHKQYFRKQVLH----GKDFQVDCKASGSPVPEISWSLPDGTM 2079
+V++ P + K H G+ ++DC+ G P PE++W + +G
Sbjct: 320 SARHAYYVTVEAAP------YWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRI-NGIP 372
Query: 2080 INNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA 2139
+ A D +R +R G L + V ++ C A+N G ++ V+
Sbjct: 373 VEEL--AKDQKYRIQR------GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL 424
Query: 2140 APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLT 2199
+I ++ G TA L C+ G P P + WL + +R+ +ANG+L
Sbjct: 425 PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV-LQDERFFPYANGTLG 483
Query: 2200 INKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHF 2259
I ++ D+G Y C+A N + T M L V + G T+ K + S+ F
Sbjct: 484 IRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQG--PRSTIEK----KGSRVTF 537
Query: 2260 DCRAEGTPS--PEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317
C+A PS P + W D L + + ++G L I ++ SD ++ CVA
Sbjct: 538 TCQASFDPSLQPSITW-RGDGRDLQELGDSDKYFI-EDGRLVIHSLDYSDQGNYSCVAST 595
Query: 2318 E 2318
E
Sbjct: 596 E 596
Score = 141 bits (355), Expect = 1e-32
Identities = 155/609 (25%), Positives = 255/609 (41%), Gaps = 53/609 (8%)
Query: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS 2000
P I S +R V D + L C A+G+P+ Q W ++ +G ++ P+
Sbjct: 35 PVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEE-LGVTVYQSPHSG 93
Query: 2001 LFI-----GSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK-QVLHGK 2054
F + ++ G+Y C A NK+G + + L + A K+ + +V G+
Sbjct: 94 SFTITGNNSNFAQRFQGIYRCFASNKLGTAMS-HEIRLMAEGAPKWPKETVKPVEVEEGE 152
Query: 2055 DFQVDCKASGSPVP-EISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
+ C S P I W + I + Q + R T+ NG LYF V ++
Sbjct: 153 SVVLPCNPPPSAEPLRIYWM---NSKILHIKQDE-------RVTMGQNGNLYFANVLTSD 202
Query: 2114 E-GDYTCYAQ----NTLGKDE-----MKVHLTVITAAPRIRQSNKTNKRIKA--GDTAVL 2161
DY C+A T+ + E +K ++I PR+ ++ + A G VL
Sbjct: 203 NHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 262
Query: 2162 DCEVTGDPKPKIFWLLPSNDMISFSIDRYTF-HANGSLTINKVKLLDSGEYVCVARNPSG 2220
+C G P P I WL PS M + DR T+ + N +L + KV D GEY C+A N G
Sbjct: 263 ECIAEGFPTPTIKWLRPSGPMPA---DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLG 319
Query: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIF 2280
Y + V + P ++ ++ TA DC+ +G P PEV W + + I
Sbjct: 320 SARHAYYVTVEAAPYWLHKPQSHLYGPGETA------RLDCQVQGRPQPEVTWRI-NGIP 372
Query: 2281 LTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
+ + + + G L + NV+ SD+ C ARN G + + V+++ +
Sbjct: 373 VEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTA 431
Query: 2341 NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
+ N+ +A G + L C G P P + W+ +GT + + Y +NG+ I
Sbjct: 432 D--NQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPY---ANGTLGIRD 486
Query: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIP 2460
D G+Y C A N + + L++ I T P + G ++ C + P
Sbjct: 487 LQANDTGRYFCLAANDQNNVTIMANLKVKDATQI-TQGPRSTIEKKGSRVTFTCQASFDP 545
Query: 2461 --KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLIT 2518
+P+I W G + + KY + D G LVI D+GNY C A +
Sbjct: 546 SLQPSITWR-GDGRDLQELGDSDKYFIED-GRLVIHSLDYSDQGNYSCVASTELDVVESR 603
Query: 2519 VPVMIVAYP 2527
+++V P
Sbjct: 604 AQLLVVGSP 612
Score = 93.2 bits (230), Expect = 3e-18
Identities = 106/419 (25%), Positives = 169/419 (40%), Gaps = 53/419 (12%)
Query: 2231 VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRI 2290
V +PP+I R V+ T K C A G P + W F G +
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLK----CEASGKPEVQFRWTRDGVHFKPKEELG--V 84
Query: 2291 TVHKN---GTLEIR----NVRLSDSADFICVARNEGGESVLVVQLEVLEMLR-RPTFRNP 2342
TV+++ G+ I N + C A N+ G ++ E+ M P +
Sbjct: 85 TVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAM---SHEIRLMAEGAPKWPKE 141
Query: 2343 FNEKIVAQLGKSTALNCSVDGNPPPE-----IIWILPNGTRFSNGPQSYQYLIASNGSFI 2397
+ + + G+S L C NPPP I W+ ++ + Q + + NG+
Sbjct: 142 TVKPVEVEEGESVVLPC----NPPPSAEPLRIYWM---NSKILHIKQDERVTMGQNGNLY 194
Query: 2398 ISKT-TREDAGKYRCAA----------RNKVGYIEKLVILEIGQKPVIL--TYAPGTVKG 2444
+ T ++ Y C A + + K I +KP +L T + +
Sbjct: 195 FANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVA 254
Query: 2445 ISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNY 2504
+ G+ L L C+++G P P IKW PSG P Y H N TL + + D G Y
Sbjct: 255 LQGQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNH-NKTLQLLKVGEEDDGEY 310
Query: 2505 ICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM 2564
C A+NS+G V + A P + P+S + G +L C G P+PE+TW +
Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2565 PDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
+ A ++ +G L++ N Q SD+ + +C A+N G A YI V+
Sbjct: 369 NGIPVEELAKDQKYRIQ-----RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 422
Score = 58.2 bits (139), Expect = 1e-07
Identities = 58/231 (25%), Positives = 97/231 (41%), Gaps = 14/231 (6%)
Query: 421 DLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNN 480
+L D + +Q + N + Q + + + L A + V+ +++ DN
Sbjct: 375 ELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQ 434
Query: 481 TKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQM 540
T + + G T L C G P P V WL DG+ V +D R +G L ++
Sbjct: 435 T---YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-----QDERFFPYANGTLGIRD 486
Query: 541 ADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI-GETLDLPCHSTG 599
+ DTG Y C+++N D ++ V+ + Q G T+ G + C ++
Sbjct: 487 LQANDTGRYFCLAAN-DQNNVTIMANLKVKDATQITQ--GPRSTIEKKGSRVTFTCQASF 543
Query: 600 IPDA--SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAA 648
P SI+W G ++ DK + +G L I + DQG Y CVA+
Sbjct: 544 DPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVAS 594
Score = 55.5 bits (132), Expect = 7e-07
Identities = 47/174 (27%), Positives = 71/174 (40%), Gaps = 5/174 (2%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G T L+C QG P P V W + + + +++D + I + G L L DT V
Sbjct: 347 GETARLDCQVQGRPQPEVTWRI---NGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVT 402
Query: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
C + N + I VV+ + + + G T L C + G P S+ W+
Sbjct: 403 QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLD 462
Query: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVK 663
+ Q R N GTL I + D G Y C+AAN ++ + VK
Sbjct: 463 EDGTTVLQDERFFPYAN-GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVK 515
Score = 55.1 bits (131), Expect = 9e-07
Identities = 47/175 (26%), Positives = 68/175 (38%), Gaps = 10/175 (5%)
Query: 480 NTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK-LEL 538
N+ L G + L C +G PTP + WL G P ++ R+ K L+L
Sbjct: 247 NSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSG-----PMPAD--RVTYQNHNKTLQL 299
Query: 539 QMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHST 598
D G Y C++ N + Y +TV ++ H GET L C
Sbjct: 300 LKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQS--HLYGPGETARLDCQVQ 357
Query: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653
G P ++W I G V + K + G L + V P D +C A N G+
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGL 412
Score = 48.1 bits (113), Expect = 1e-04
Identities = 49/210 (23%), Positives = 89/210 (42%), Gaps = 34/210 (16%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
G +V L C +P P + L + ++ +D R+ + ++G L + D
Sbjct: 151 GESVVLPC----NPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD 206
Query: 550 HCISSNYDDA------DILTYRITVVEPLVEA-----YQENGIHHTVFI-GETLDLPCHS 597
+ +++ + + R+ +++ + N H V + G+ L L C +
Sbjct: 207 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA 266
Query: 598 TGIPDASISWV-----IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
G P +I W+ +P + V YQ+ +N TL++L+V +D G YRC+A N G
Sbjct: 267 EGFPTPTIKWLRPSGPMPADRVTYQN-------HNKTLQLLKVGEEDDGEYRCLAENSLG 319
Query: 653 VDFLIFQVSVKM------KGQRPLEHDGET 676
+ V+V+ K Q L GET
Sbjct: 320 SARHAYYVTVEAAPYWLHKPQSHLYGPGET 349
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 157 bits (398), Expect = 1e-37
Identities = 128/507 (25%), Positives = 215/507 (42%), Gaps = 62/507 (12%)
Query: 1840 APPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSN 1899
A P I+EQ ++V GE LPC A+G P+P++ W + + + L +
Sbjct: 62 AMPRIVEQPPDLLVSR-GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
Query: 1900 GTLYIRNL-----ASSDRGTYECIA------TSSTGSERRVVMLTMEERVTSPRIEAASQ 1948
G L+ + A D G Y C+A +S + V +L + R + + A
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA-- 178
Query: 1949 KRTEVNFGDKLLLNC-SATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007
G+ +L C G P+P + WR + +++ R+ G L +
Sbjct: 179 ------VGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRI-----TIRGGKLMMSHTL 227
Query: 2008 EKDSGVYLCVARNKMGD-DLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSP 2066
+ D+G+Y+CVA N G+ + V + +P+ + ++ + VL C+ G P
Sbjct: 228 KSDAGMYVCVASNMAGERESAAAEVMVLERPSFL--RRPVNQVVLADAPVTFLCEVKGDP 285
Query: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
P + W DG + T RY + ++ +L+ V +EG YTC A+N++G
Sbjct: 286 PPRLRWRKEDGEL------------PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
Query: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISF- 2185
+ E L+V + Q ++ G++ CE G+P P IFW + ++ F
Sbjct: 334 RAEASGSLSVHVPPQLVTQPQ--DQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
Query: 2186 -----SIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK-----PP 2235
R++ G L I V+ D+G YVC A + +G L++ PP
Sbjct: 392 SQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPP 451
Query: 2236 LINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKN 2295
+I N+T++ ++V CR G P P V W D +L + N
Sbjct: 452 VILQGPANQTLVLGSSV-----WLPCRVTGNPQPSVRW-KKDGQWLQGD--DLQFKTMAN 503
Query: 2296 GTLEIRNVRLSDSADFICVARNEGGES 2322
GTL I NV+ D + CVA++ GE+
Sbjct: 504 GTLYIANVQEMDMGFYSCVAKSSTGEA 530
Score = 149 bits (376), Expect = 4e-35
Identities = 128/515 (24%), Positives = 213/515 (41%), Gaps = 59/515 (11%)
Query: 1632 SKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDL 1691
S++ P D++ R + + P ++ + A LPC A G P P I W + + +
Sbjct: 55 SRVGPEDAMPRIVEQPPDLL--------VSRGEPATLPCRAEGRPRPNIEWYKNGARVAT 106
Query: 1692 SKRKQNSRVQVLPNGTLSIQRV-----EIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR 1746
+ + +LP+G L R+ D G Y C A N G V+
Sbjct: 107 VREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRD 166
Query: 1747 ILERRTKEITVHSGSTVELKC-RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTL 1805
+ + V G L+C G P P+V+W + E + + G L
Sbjct: 167 DFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGR-----ITIRGGKL 221
Query: 1806 VLHNLSIYDRGFYKCVASNPGGQ-DSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPC 1864
++ + D G Y CVASN G+ +S ++ V+ P + QV++ + C
Sbjct: 222 MMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLA--DAPVTFLC 279
Query: 1865 TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG 1924
KG P P + W DG + + + S+ +L+I ++++ D GTY C+A +S G
Sbjct: 280 EVKGDPPPRLRWRKEDG------ELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
Query: 1925 SERRVVMLTME---ERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKA 1981
L++ + VT P+ + A+ G+ + C G P P I W+
Sbjct: 334 RAEASGSLSVHVPPQLVTQPQDQMAAP-------GESVAFQCETKGNPPPAIFWQKEGSQ 386
Query: 1982 VV---DQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPA 2038
V+ Q + V P G L I +V D+G Y+C A + G IL L +K A
Sbjct: 387 VLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGS--ILAKALLEIKGA 444
Query: 2039 KIDH------KQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHR 2092
+D + + ++ G + C+ +G+P P + W DG +Q DD +
Sbjct: 445 SLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWK-KDGQW----LQGDDLQFK 499
Query: 2093 TRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGK 2127
T NGTLY V + G Y+C A+++ G+
Sbjct: 500 T-----MANGTLYIANVQEMDMGFYSCVAKSSTGE 529
Score = 149 bits (376), Expect = 4e-35
Identities = 130/494 (26%), Positives = 201/494 (40%), Gaps = 41/494 (8%)
Query: 1745 PRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGT 1804
PRI+E+ ++ V G L CRAEGRP P + W V + ++ G
Sbjct: 64 PRIVEQ-PPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGA 122
Query: 1805 L----VLHNLSIY-DRGFYKCVASN-PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGE 1858
L ++H D G Y CVA N G S ++V + V+V GE
Sbjct: 123 LFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAV-GE 181
Query: 1859 SLKLPCT-AKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYEC 1917
L C +G P+PSV W DG +K G L + + SD G Y C
Sbjct: 182 PAVLECVPPRGHPEPSVSW-RKDGARLK----EEEGRITIRGGKLMMSHTLKSDAGMYVC 236
Query: 1918 IATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVN----FGDKLLLNCSATGEPKPQI 1973
+A++ G M +E S R VN + C G+P P++
Sbjct: 237 VASNMAGERESAAAEVMV-------LERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL 289
Query: 1974 MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSL 2033
WR + ++ + S + SL+IG V+ +D G Y CVA N +G +S+
Sbjct: 290 RWRKEDGELPTGRYEIRS------DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343
Query: 2034 RLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRT 2093
+ P + Q + G+ C+ G+P P I W +G+ + + S T
Sbjct: 344 HVPPQLVTQPQ--DQMAAPGESVAFQCETKGNPPPAIFWQ-KEGSQV--LLFPSQSLQPT 398
Query: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV----ITAAPRIRQSNKT 2149
R+++ G L V + G Y C A + G K L + + P +
Sbjct: 399 GRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPA 458
Query: 2150 NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSG 2209
N+ + G + L C VTG+P+P + W + + T ANG+L I V+ +D G
Sbjct: 459 NQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTM-ANGTLYIANVQEMDMG 517
Query: 2210 EYVCVARNPSGDDT 2223
Y CVA++ +G+ T
Sbjct: 518 FYSCVAKSSTGEAT 531
Score = 134 bits (336), Expect = 2e-30
Identities = 136/500 (27%), Positives = 197/500 (39%), Gaps = 59/500 (11%)
Query: 2139 AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA---N 2195
A PRI + + + G+ A L C G P+P I W + + D +
Sbjct: 62 AMPRIVEQ-PPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
Query: 2196 GSLTINKV-----KLLDSGEYVCVARNPSGD--------DTKMYKLDVVSKPPLINGLYT 2242
G+L ++ D G Y CVARN G + + + D P +
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
Query: 2243 NRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRN 2302
V++ R G P P V W D L RIT+ + G L + +
Sbjct: 181 EPAVLECVPPR-----------GHPEPSVSW-RKDGARLKEEE--GRITI-RGGKLMMSH 225
Query: 2303 VRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF-RNPFNEKIVAQLGKSTALNCSV 2361
SD+ ++CVA N GE EV+ +L RP+F R P N+ ++A C V
Sbjct: 226 TLKSDAGMYVCVASNMAGERESAAA-EVM-VLERPSFLRRPVNQVVLADA--PVTFLCEV 281
Query: 2362 DGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIE 2421
G+PPP + W +G + +Y I S+ S I + ED G Y C A N VG E
Sbjct: 282 KGDPPPRLRWRKEDGELPTG-----RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAE 336
Query: 2422 KLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRP---- 2477
L + P ++T P GES++ C + G P P I W V+ P
Sbjct: 337 ASGSLSVHVPPQLVTQ-PQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSL 395
Query: 2478 QINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVA-----YPPRITN 2532
Q G++ + G L I D G Y+C+A + G L + I PP I
Sbjct: 396 QPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQ 455
Query: 2533 RPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVI 2592
P + G++ L C G P+P + W+ L + +T + GTL I
Sbjct: 456 GPANQTLV-LGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN------GTLYI 508
Query: 2593 QNPQTSDSGIYKCTAKNPLG 2612
N Q D G Y C AK+ G
Sbjct: 509 ANVQEMDMGFYSCVAKSSTG 528
Score = 112 bits (279), Expect = 6e-24
Identities = 89/302 (29%), Positives = 137/302 (45%), Gaps = 24/302 (7%)
Query: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVL 1703
+ E+P + + + + A++ CE G+P P + W + L R ++
Sbjct: 254 VLERPSFLR-RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP------TGRYEIR 306
Query: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTV 1763
+ +L I V +D G Y C A N G +LSV PP+++ + ++ G +V
Sbjct: 307 SDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQDQMAA-PGESV 364
Query: 1764 ELKCRAEGRPSPTVTWILANQTVV---SESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKC 1820
+C +G P P + W V+ S+S Q + + V+ G L + + D G+Y C
Sbjct: 365 AFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC 424
Query: 1821 VASNPGGQDSLLVKIQVIAA-----PPVILE-QRRQVIVGTWGESLKLPCTAKGTPQPSV 1874
A + G +++ A PPVIL+ Q +V G S+ LPC G PQPSV
Sbjct: 425 QAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLV--LGSSVWLPCRVTGNPQPSV 482
Query: 1875 YWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTM 1934
W DG + LQ + + +NGTLYI N+ D G Y C+A SSTG L M
Sbjct: 483 RWK-KDG---QWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKM 538
Query: 1935 EE 1936
E
Sbjct: 539 RE 540
Score = 99.4 bits (246), Expect = 4e-20
Identities = 96/372 (25%), Positives = 150/372 (40%), Gaps = 25/372 (6%)
Query: 2261 CRAEGTPSPEVMWIMPDNIFLTAPY--YGSRITVHKNGTLEIRNVR----LSDSADFICV 2314
CRAEG P P + W T R+ + R V D + CV
Sbjct: 85 CRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCV 144
Query: 2315 ARNE-GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVD-GNPPPEIIWI 2372
ARN G + LEV +LR ++P N +V +G+ L C G+P P + W
Sbjct: 145 ARNYLGAAASRNASLEVA-VLRDDFRQSPGN--VVVAVGEPAVLECVPPRGHPEPSVSW- 200
Query: 2373 LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI-LEIGQK 2431
+G R + + G ++S T + DAG Y C A N G E + + ++
Sbjct: 201 RKDGARLK---EEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLER 257
Query: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTL 2491
P L V ++ ++ C G P P ++W G + G+Y + + +L
Sbjct: 258 PSFLRRPVNQVV-LADAPVTFLCEVKGDPPPRLRWRKEDGELP-----TGRYEIRSDHSL 311
Query: 2492 VIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCV 2551
I +A D G Y C A+NSVG + + + P +T P+ + G + C
Sbjct: 312 WIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQ--PQDQMAAPGESVAFQCE 369
Query: 2552 ALGVPKPEITWEMPDHSLLSTASKE-RTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNP 2610
G P P I W+ +L S+ + G + +G L I Q D+G Y C A +
Sbjct: 370 TKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSV 429
Query: 2611 LGSDYAATYIQV 2622
GS A +++
Sbjct: 430 AGSILAKALLEI 441
Score = 89.7 bits (221), Expect = 3e-17
Identities = 73/285 (25%), Positives = 112/285 (39%), Gaps = 23/285 (8%)
Query: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS---NGPQSYQYLIASNGSF----IIS 2399
++ G+ L C +G P P I W NG R + P++++ L+ S F +
Sbjct: 73 LLVSRGEPATLPCRAEGRPRPNIEW-YKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
Query: 2400 KTTREDAGKYRCAARNKVG-YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSD- 2457
+ R D G Y C ARN +G + LE+ +PG V GE L CV
Sbjct: 132 RRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPR 191
Query: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
G P+P++ W + + G+ + G L++ D G Y+C A N G
Sbjct: 192 GHPEPSVSWRKDGARLKEE---EGRITIR-GGKLMMSHTLKSDAGMYVCVASNMAGERES 247
Query: 2518 TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKER 2577
++V P RP +V A C G P P + W D L +
Sbjct: 248 AAAEVMVLERPSFLRRPVNQVVL-ADAPVTFLCEVKGDPPPRLRWRKEDGELPT------ 300
Query: 2578 THGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
G ++ +L I + D G Y C A+N +G A+ + V
Sbjct: 301 --GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343
Score = 66.6 bits (161), Expect = 3e-10
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 9/170 (5%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVR---APYVSEDGRILIDKSGKLELQMADSFDT 546
G +V C +G+P P + W +GS+V + + GR + G+L + D
Sbjct: 361 GESVAFQCETKGNPPPAIFWQ-KEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
Query: 547 GVYHC----ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
G Y C ++ + +L + ++ L + + T+ +G ++ LPC TG P
Sbjct: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
S+ W G L K + NGTL I V D G+Y CVA + +G
Sbjct: 480 PSVRWKKDGQ-WLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528
Score = 57.4 bits (137), Expect = 2e-07
Identities = 50/185 (27%), Positives = 75/185 (40%), Gaps = 15/185 (8%)
Query: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVD-RPQINGKYILHDNGTL-----VIKEATAYD 2500
GE +L C ++G P+PNI+W V R +L +G L V D
Sbjct: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPD 137
Query: 2501 RGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCV-ALGVPKPE 2559
G Y C A+N +G + VA + P ++V G L CV G P+P
Sbjct: 138 EGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPS 197
Query: 2560 ITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS-DYAAT 2618
++W L + G G L++ + SD+G+Y C A N G + AA
Sbjct: 198 VSWRKDGARLKEEEGRITIRG-------GKLMMSHTLKSDAGMYVCVASNMAGERESAAA 250
Query: 2619 YIQVI 2623
+ V+
Sbjct: 251 EVMVL 255
Score = 53.1 bits (126), Expect = 3e-06
Identities = 49/171 (28%), Positives = 74/171 (43%), Gaps = 13/171 (7%)
Query: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRI--LIDKSGKLELQMADSF--- 544
G L C +G P P+++W +G++V V ED R L+ SG L
Sbjct: 78 GEPATLPCRAEGRPRPNIEWY-KNGARVAT--VREDPRAHRLLLPSGALFFPRIVHGRRA 134
Query: 545 --DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC-HSTGIP 601
D GVY C++ NY A V L + ++++ + V +GE L C G P
Sbjct: 135 RPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHP 194
Query: 602 DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ S+SW G + + R + G L + D G Y CVA+N +G
Sbjct: 195 EPSVSWRKDGARLKEEEGR--ITIRGGKLMMSHTLKSDAGMYVCVASNMAG 243
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/178 (26%), Positives = 68/178 (38%), Gaps = 19/178 (10%)
Query: 483 LEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
+ VL V C +GDP P + W DG GR I L +
Sbjct: 265 VNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE-------LPTGRYEIRSDHSLWIGHVS 317
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEP--LVEAYQENGIHHTVFIGETLDLPCHSTGI 600
+ D G Y C++ N + ++V P LV Q+ GE++ C + G
Sbjct: 318 AEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD----QMAAPGESVAFQCETKGN 373
Query: 601 PDASISWVIPGNNVLYQSSRDKK------VLNNGTLRILQVTPKDQGYYRCVAANPSG 652
P +I W G+ VL S+ + V G L I V D GYY C A + +G
Sbjct: 374 PPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAG 431
Score = 40.4 bits (93), Expect = 0.023
Identities = 30/91 (32%), Positives = 39/91 (42%), Gaps = 8/91 (8%)
Query: 2528 PRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQ 2587
PRI +PP +V+R G L C A G P+P I W + + R H L
Sbjct: 64 PRIVEQPPDLLVSR-GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAH--RLLLPS 120
Query: 2588 GTL-----VIQNPQTSDSGIYKCTAKNPLGS 2613
G L V D G+Y C A+N LG+
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGA 151
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 156 bits (394), Expect = 3e-37
Identities = 164/626 (26%), Positives = 257/626 (41%), Gaps = 84/626 (13%)
Query: 1661 PANSD---AFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQR-VEIQ 1716
P +SD L CE GNP+P+ W R + +DL + S L +GT I E +
Sbjct: 111 PTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS----LIDGTFIISNPSEAK 166
Query: 1717 DRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPT 1776
D G Y C A+N G+ +Y R ++V G V L C SP
Sbjct: 167 DSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPH-SPE 225
Query: 1777 VTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQ 1836
+ + S ++ SR+ + G L + + D G Y C+ N V
Sbjct: 226 IIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN-------TVTNA 278
Query: 1837 VIAAPPVILEQRRQVIVGTW----------------GESLKLPCTAKGTPQPSVYWVLSD 1880
+ +PP L R ++G + G ++K+ C A G P P++ W+ +
Sbjct: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVN 338
Query: 1881 GTEVKPLQFTNSKLFL-FSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
G + SK L S L I N+ D G YEC A +S G L + T
Sbjct: 339 G-------YIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQV---YT 388
Query: 1940 SPR-IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN 1998
P +E + T+++ G L C ATG+P+P W L + + Q RV N
Sbjct: 389 YPHWVEKLND--TQLDSGSPLRWECKATGKPRPTYRW-LKNGVPLSPQSRV-----EMVN 440
Query: 1999 GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLK---PAKIDHKQYFRKQVLHGKD 2055
G L I +V + D+G+Y C+A NK G ++ S LK A +K ++ KD
Sbjct: 441 GVLMIHNVNQSDAGMYQCLAENKYG----AIYASAELKILASAPTFALNQLKKTIIVTKD 496
Query: 2056 FQV--DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
+V +CK GSP P ISW D + N +R + +G+L ++
Sbjct: 497 QEVVIECKPQGSPKPTISWKKGDRAVREN-----------KRIAILPDGSLRILNASKSD 545
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKI 2173
EG Y C +N G E+ L+V RI + K + + G++ VL+C+ D +
Sbjct: 546 EGKYVCRGENVFGSAEIIASLSV-KEPTRIELTPKRTE-LTVGESIVLNCKAIHDASLDV 603
Query: 2174 --FWLLPSNDMISFSIDRYTFH------ANGSLTINKVKLLDSGEYVCVARNPSGDDTKM 2225
+W L I F + F ++ L I + L+ +G Y C + + +
Sbjct: 604 TFYWTL-KGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 662
Query: 2226 YKLDVVSKPPLINGLYTNRTVIKATA 2251
+L +V PP G+ + ++TA
Sbjct: 663 AEL-LVRGPPGPPGIVIVEEITESTA 687
Score = 149 bits (376), Expect = 4e-35
Identities = 147/595 (24%), Positives = 246/595 (41%), Gaps = 68/595 (11%)
Query: 1842 PVILEQRRQVIVGTWGESLK--LPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSN 1899
PV +++ +I T + K L C +G P PS W L +GTE+ + + +
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRW-LRNGTEI---DLESDYRYSLID 154
Query: 1900 GTLYIRNLASS-DRGTYECIATSSTGSERRVVMLTMEERVTSPRI---EAASQKRTEVNF 1955
GT I N + + D G Y+C+AT++ GS +L+ E + + ++ V
Sbjct: 155 GTFIISNPSEAKDSGHYQCLATNTVGS-----ILSREATLQFAYLGNFSGRTRSAVSVRE 209
Query: 1956 GDKLLLNCSATGEPKPQIMW-----RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD 2010
G ++L CS P+I++ PS D + + G+L+I V D
Sbjct: 210 GQGVVLMCSPPPH-SPEIIYSWVFNEFPSFVAEDSRRFISQ-----ETGNLYISKVQTSD 263
Query: 2011 SGVYLCVARNKMGDDLILMHVS-LRLK--------PAKIDHKQYFRKQVLHGKDFQVDCK 2061
G Y+C+ +N + + +L + L L+ KI+ F G +++C
Sbjct: 264 VGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECF 323
Query: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYA 2121
A G+PVP I+W +G + + A R R+ + L V + + G Y C A
Sbjct: 324 ALGNPVPTITWMKVNGYIPSKA--------RLRK----SQAVLEIPNVQLDDAGIYECRA 371
Query: 2122 QNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSND 2181
+N+ GK+ + L V T + + N T ++ +G +C+ TG P+P WL +
Sbjct: 372 ENSRGKNSFRGQLQVYTYPHWVEKLNDT--QLDSGSPLRWECKATGKPRPTYRWL---KN 426
Query: 2182 MISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLY 2241
+ S NG L I+ V D+G Y C+A N G +L +++ P
Sbjct: 427 GVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ 486
Query: 2242 TNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIR 2301
+T+I + + +C+ +G+P P + W D A RI + +G+L I
Sbjct: 487 LKKTII---VTKDQEVVIECKPQGSPKPTISWKKGDR----AVRENKRIAILPDGSLRIL 539
Query: 2302 NVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSV 2361
N SD ++C N G + ++ L V E PT ++ +G+S LNC
Sbjct: 540 NASKSDEGKYVCRGENVFGSAEIIASLSVKE----PTRIELTPKRTELTVGESIVLNCKA 595
Query: 2362 --DGNPPPEIIWIL---PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRC 2411
D + W L P G AS+ +I AG+Y C
Sbjct: 596 IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 650
Score = 145 bits (366), Expect = 5e-34
Identities = 105/367 (28%), Positives = 178/367 (48%), Gaps = 32/367 (8%)
Query: 1658 FTIPA--NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEI 1715
FT+ A + + C A+GNP+PTI W +V + R + S+ L I V++
Sbjct: 308 FTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQ------AVLEIPNVQL 361
Query: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775
D G Y C A N G + L V +YP + + + + SGS + +C+A G+P P
Sbjct: 362 DDAGIYECRAENSRGKNSFRGQLQVYTYPHWV--EKLNDTQLDSGSPLRWECKATGKPRP 419
Query: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKI 1835
T W L N +S S+ V V+G L++HN++ D G Y+C+A N G ++
Sbjct: 420 TYRW-LKNGVPLSPQSR-----VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAEL 473
Query: 1836 QVIA-APPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+++A AP L Q ++ I+ T + + + C +G+P+P++ W D + N ++
Sbjct: 474 KILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE-----NKRI 528
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVN 1954
+ +G+L I N + SD G Y C + GS + L+++E RIE + KRTE+
Sbjct: 529 AILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE---PTRIE-LTPKRTELT 584
Query: 1955 FGDKLLLNCSATGEPKPQI--MWRLPSKAVVDQQHRVGSWIHVYPNGS---LFIGSVTEK 2009
G+ ++LNC A + + W L + +D + G + + S L I ++
Sbjct: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQP-IDFEEEGGHFESIRAQASSADLMIRNILLM 643
Query: 2010 DSGVYLC 2016
+G Y C
Sbjct: 644 HAGRYGC 650
Score = 143 bits (361), Expect = 2e-33
Identities = 155/584 (26%), Positives = 243/584 (41%), Gaps = 66/584 (11%)
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
K ++C+ G+PVP W L +GT I+ +++D RY+L + + N +
Sbjct: 117 KKVALNCEVRGNPVPSYRW-LRNGTEID--LESD------YRYSLIDGTFIISNPSEAKD 167
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKI 2173
G Y C A NT+G + ++ ++ G VL C P+I
Sbjct: 168 SGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPH-SPEI 226
Query: 2174 FWLLPSNDMISFSID---RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
+ N+ SF + R+ G+L I+KV+ D G Y+C+ +N + V
Sbjct: 227 IYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNT------VTNARV 280
Query: 2231 VSKP-PL------INGLYTNRTVIK----ATAVRHSKKHFDCRAEGTPSPEVMWIMPDNI 2279
+S P PL + G Y + + TA + + +C A G P P + W+ +
Sbjct: 281 LSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNG- 339
Query: 2280 FLTAPYYGSRITVHKN-GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPT 2338
Y S+ + K+ LEI NV+L D+ + C A N G++ QL+V P
Sbjct: 340 -----YIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTY---PH 391
Query: 2339 FRNPFNEKIVAQLGKSTALN--CSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSF 2396
+ N+ QL + L C G P P W L NG S PQS ++ NG
Sbjct: 392 WVEKLND---TQLDSGSPLRWECKATGKPRPTYRW-LKNGVPLS--PQSRVEMV--NGVL 443
Query: 2397 IISKTTREDAGKYRCAARNKVGYIEKLVILEI--GQKPVILTYAPGTVKGISGESLSLHC 2454
+I + DAG Y+C A NK G I L+I L T+ + + + C
Sbjct: 444 MIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIEC 503
Query: 2455 VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGH 2514
G PKP I W V + +I IL D G+L I A+ D G Y+C+ +N G
Sbjct: 504 KPQGSPKPTISWKKGDRAVRENKRIA---ILPD-GSLRILNASKSDEGKYVCRGENVFGS 559
Query: 2515 TLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT--WEMPDHSLLST 2572
I + + V P RI P R+ +T G + L+C A+ ++T W + +
Sbjct: 560 AEI-IASLSVKEPTRIELTPKRTELT-VGESIVLNCKAIHDASLDVTFYWTLKGQPI--- 614
Query: 2573 ASKERTHGSEQLHLQGT---LVIQNPQTSDSGIYKCTAKNPLGS 2613
+E E + Q + L+I+N +G Y C + S
Sbjct: 615 DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADS 658
Score = 107 bits (266), Expect = 2e-22
Identities = 100/394 (25%), Positives = 157/394 (39%), Gaps = 41/394 (10%)
Query: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDN-IFLTAPYYGSRITVHKNGTLEIRNV- 2303
+I T K +C G P P W+ I L + Y S I +GT I N
Sbjct: 108 IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI----DGTFIISNPS 163
Query: 2304 RLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDG 2363
DS + C+A N G ++ + L+ F + + G+ L CS
Sbjct: 164 EAKDSGHYQCLATNTVGS--ILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSP-- 219
Query: 2364 NPP--PEII--WILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGY 2419
PP PEII W+ F S +++ G+ ISK D G Y C +N V
Sbjct: 220 -PPHSPEIIYSWVFNEFPSFV-AEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTN 277
Query: 2420 IE------KLVILEIG----QKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP 2469
L + G +P I + P TV G ++ + C + G P P I W
Sbjct: 278 ARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKV 337
Query: 2470 SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
+GY+ + ++ L I D G Y C+A+NS G + + YP
Sbjct: 338 NGYIPSKARLR-----KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 392
Query: 2530 ITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT 2589
+ + +G+ + C A G P+P W + + LS S+ + G
Sbjct: 393 VEKLNDTQL--DSGSPLRWECKATGKPRPTYRW-LKNGVPLSPQSRVEM-------VNGV 442
Query: 2590 LVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L+I N SD+G+Y+C A+N G+ YA+ ++++
Sbjct: 443 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 476
Score = 72.4 bits (176), Expect = 6e-12
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 17/184 (9%)
Query: 1660 IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRG 1719
+ + + + C+ G+P PTI W + + ++N R+ +LP+G+L I D G
Sbjct: 493 VTKDQEVVIECKPQGSPKPTISWKKGDRAV-----RENKRIAILPDGSLRILNASKSDEG 547
Query: 1720 QYLCSASNLFGTDHLHVTLSVVSYPPRI-LERRTKEITVHSGSTVELKCRAEGRPSPTVT 1778
+Y+C N+FG+ + +LS V P RI L + E+TV G ++ L C+A S VT
Sbjct: 548 KYVCRGENVFGSAEIIASLS-VKEPTRIELTPKRTELTV--GESIVLNCKAIHDASLDVT 604
Query: 1779 --WILANQTVVSESSQGSRQAV--VTVDGTLVLHNLSIYDRGFYKC----VASNPGGQDS 1830
W L Q + E G +++ L++ N+ + G Y C A + +
Sbjct: 605 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 664
Query: 1831 LLVK 1834
LLV+
Sbjct: 665 LLVR 668
Score = 54.7 bits (130), Expect = 1e-06
Identities = 48/191 (25%), Positives = 86/191 (45%), Gaps = 16/191 (8%)
Query: 475 ISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG 534
+ + N+T+L+ G + C G P P WL K P +S R+ + +G
Sbjct: 393 VEKLNDTQLDS----GSPLRWECKATGKPRPTYRWL-----KNGVP-LSPQSRVEM-VNG 441
Query: 535 KLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLD-- 592
L + + D G+Y C++ N A + + ++ + N + T+ + + +
Sbjct: 442 VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILAS-APTFALNQLKKTIIVTKDQEVV 500
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ C G P +ISW G+ + ++ R +L +G+LRIL + D+G Y C N G
Sbjct: 501 IECKPQGSPKPTISWK-KGDRAVRENKRIA-ILPDGSLRILNASKSDEGKYVCRGENVFG 558
Query: 653 VDFLIFQVSVK 663
+I +SVK
Sbjct: 559 SAEIIASLSVK 569
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/183 (24%), Positives = 73/183 (39%), Gaps = 24/183 (13%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T G TV + C G+P P + W+ +G Y+ R L LE+ D
Sbjct: 311 TAAKGTTVKMECFALGNPVPTITWMKVNG------YIPSKAR-LRKSQAVLEIPNVQLDD 363
Query: 546 TGVYHCISSNYDDADILTYRITV------VEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
G+Y C + N + ++ V VE L + ++ G L C +TG
Sbjct: 364 AGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS--------GSPLRWECKATG 415
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQ 659
P + W+ N + S + + + NG L I V D G Y+C+A N G + +
Sbjct: 416 KPRPTYRWL---KNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAE 472
Query: 660 VSV 662
+ +
Sbjct: 473 LKI 475
Score = 43.1 bits (100), Expect = 0.004
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 36/192 (18%)
Query: 482 KLEHTVLV--GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
+L+ T++V V + C QG P P + W D + V E+ RI I G L +
Sbjct: 486 QLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA------VRENKRIAILPDGSLRIL 539
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
A D G Y C N + + ++V EP TV GE++ L C +
Sbjct: 540 NASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTV--GESIVLNCKA-- 595
Query: 600 IPDASIS----WVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDF 655
I DAS+ W + G + ++ ++ G++ + A S D
Sbjct: 596 IHDASLDVTFYWTLKGQPIDFE--------------------EEGGHFESIRAQASSADL 635
Query: 656 LIFQVSVKMKGQ 667
+I + + G+
Sbjct: 636 MIRNILLMHAGR 647
Score = 35.8 bits (81), Expect = 0.57
Identities = 48/171 (28%), Positives = 71/171 (41%), Gaps = 30/171 (17%)
Query: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAP----YVSEDGRILIDKSGKLELQMADSFDTGV 548
V LNC +G+P P W L +G+++ Y DG +I +++ D+G
Sbjct: 119 VALNCEVRGNPVPSYRW-LRNGTEIDLESDYRYSLIDGTFIISNP-------SEAKDSGH 170
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHT-----VFIGETLDLPC----HSTG 599
Y C+++N IL+ T L AY N T V G+ + L C HS
Sbjct: 171 YQCLATN-TVGSILSREAT----LQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHS-- 223
Query: 600 IPDASISWVI-PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
P+ SWV + + + SR G L I +V D G Y C+ N
Sbjct: 224 -PEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 156 bits (394), Expect = 3e-37
Identities = 164/626 (26%), Positives = 257/626 (41%), Gaps = 84/626 (13%)
Query: 1661 PANSD---AFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQR-VEIQ 1716
P +SD L CE GNP+P+ W R + +DL + S L +GT I E +
Sbjct: 37 PTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS----LIDGTFIISNPSEAK 92
Query: 1717 DRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPT 1776
D G Y C A+N G+ +Y R ++V G V L C SP
Sbjct: 93 DSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPH-SPE 151
Query: 1777 VTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQ 1836
+ + S ++ SR+ + G L + + D G Y C+ N V
Sbjct: 152 IIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN-------TVTNA 204
Query: 1837 VIAAPPVILEQRRQVIVGTW----------------GESLKLPCTAKGTPQPSVYWVLSD 1880
+ +PP L R ++G + G ++K+ C A G P P++ W+ +
Sbjct: 205 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVN 264
Query: 1881 GTEVKPLQFTNSKLFL-FSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
G + SK L S L I N+ D G YEC A +S G L + T
Sbjct: 265 G-------YIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQV---YT 314
Query: 1940 SPR-IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN 1998
P +E + T+++ G L C ATG+P+P W L + + Q RV N
Sbjct: 315 YPHWVEKLND--TQLDSGSPLRWECKATGKPRPTYRW-LKNGVPLSPQSRV-----EMVN 366
Query: 1999 GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLK---PAKIDHKQYFRKQVLHGKD 2055
G L I +V + D+G+Y C+A NK G ++ S LK A +K ++ KD
Sbjct: 367 GVLMIHNVNQSDAGMYQCLAENKYG----AIYASAELKILASAPTFALNQLKKTIIVTKD 422
Query: 2056 FQV--DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
+V +CK GSP P ISW D + N +R + +G+L ++
Sbjct: 423 QEVVIECKPQGSPKPTISWKKGDRAVREN-----------KRIAILPDGSLRILNASKSD 471
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKI 2173
EG Y C +N G E+ L+V RI + K + + G++ VL+C+ D +
Sbjct: 472 EGKYVCRGENVFGSAEIIASLSV-KEPTRIELTPKRTE-LTVGESIVLNCKAIHDASLDV 529
Query: 2174 --FWLLPSNDMISFSIDRYTFH------ANGSLTINKVKLLDSGEYVCVARNPSGDDTKM 2225
+W L I F + F ++ L I + L+ +G Y C + + +
Sbjct: 530 TFYWTL-KGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 588
Query: 2226 YKLDVVSKPPLINGLYTNRTVIKATA 2251
+L +V PP G+ + ++TA
Sbjct: 589 AEL-LVRGPPGPPGIVIVEEITESTA 613
Score = 149 bits (376), Expect = 4e-35
Identities = 147/595 (24%), Positives = 246/595 (41%), Gaps = 68/595 (11%)
Query: 1842 PVILEQRRQVIVGTWGESLK--LPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSN 1899
PV +++ +I T + K L C +G P PS W L +GTE+ + + +
Sbjct: 25 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRW-LRNGTEI---DLESDYRYSLID 80
Query: 1900 GTLYIRNLASS-DRGTYECIATSSTGSERRVVMLTMEERVTSPRI---EAASQKRTEVNF 1955
GT I N + + D G Y+C+AT++ GS +L+ E + + ++ V
Sbjct: 81 GTFIISNPSEAKDSGHYQCLATNTVGS-----ILSREATLQFAYLGNFSGRTRSAVSVRE 135
Query: 1956 GDKLLLNCSATGEPKPQIMW-----RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD 2010
G ++L CS P+I++ PS D + + G+L+I V D
Sbjct: 136 GQGVVLMCSPPPH-SPEIIYSWVFNEFPSFVAEDSRRFISQ-----ETGNLYISKVQTSD 189
Query: 2011 SGVYLCVARNKMGDDLILMHVS-LRLK--------PAKIDHKQYFRKQVLHGKDFQVDCK 2061
G Y+C+ +N + + +L + L L+ KI+ F G +++C
Sbjct: 190 VGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECF 249
Query: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYA 2121
A G+PVP I+W +G + + A R R+ + L V + + G Y C A
Sbjct: 250 ALGNPVPTITWMKVNGYIPSKA--------RLRK----SQAVLEIPNVQLDDAGIYECRA 297
Query: 2122 QNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSND 2181
+N+ GK+ + L V T + + N T ++ +G +C+ TG P+P WL +
Sbjct: 298 ENSRGKNSFRGQLQVYTYPHWVEKLNDT--QLDSGSPLRWECKATGKPRPTYRWL---KN 352
Query: 2182 MISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLY 2241
+ S NG L I+ V D+G Y C+A N G +L +++ P
Sbjct: 353 GVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ 412
Query: 2242 TNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIR 2301
+T+I + + +C+ +G+P P + W D A RI + +G+L I
Sbjct: 413 LKKTII---VTKDQEVVIECKPQGSPKPTISWKKGDR----AVRENKRIAILPDGSLRIL 465
Query: 2302 NVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSV 2361
N SD ++C N G + ++ L V E PT ++ +G+S LNC
Sbjct: 466 NASKSDEGKYVCRGENVFGSAEIIASLSVKE----PTRIELTPKRTELTVGESIVLNCKA 521
Query: 2362 --DGNPPPEIIWIL---PNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRC 2411
D + W L P G AS+ +I AG+Y C
Sbjct: 522 IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 576
Score = 145 bits (366), Expect = 5e-34
Identities = 105/367 (28%), Positives = 178/367 (48%), Gaps = 32/367 (8%)
Query: 1658 FTIPA--NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEI 1715
FT+ A + + C A+GNP+PTI W +V + R + S+ L I V++
Sbjct: 234 FTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQ------AVLEIPNVQL 287
Query: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775
D G Y C A N G + L V +YP + + + + SGS + +C+A G+P P
Sbjct: 288 DDAGIYECRAENSRGKNSFRGQLQVYTYPHWV--EKLNDTQLDSGSPLRWECKATGKPRP 345
Query: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKI 1835
T W L N +S S+ V V+G L++HN++ D G Y+C+A N G ++
Sbjct: 346 TYRW-LKNGVPLSPQSR-----VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAEL 399
Query: 1836 QVIA-APPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
+++A AP L Q ++ I+ T + + + C +G+P+P++ W D + N ++
Sbjct: 400 KILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE-----NKRI 454
Query: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVN 1954
+ +G+L I N + SD G Y C + GS + L+++E RIE + KRTE+
Sbjct: 455 AILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE---PTRIE-LTPKRTELT 510
Query: 1955 FGDKLLLNCSATGEPKPQI--MWRLPSKAVVDQQHRVGSWIHVYPNGS---LFIGSVTEK 2009
G+ ++LNC A + + W L + +D + G + + S L I ++
Sbjct: 511 VGESIVLNCKAIHDASLDVTFYWTLKGQP-IDFEEEGGHFESIRAQASSADLMIRNILLM 569
Query: 2010 DSGVYLC 2016
+G Y C
Sbjct: 570 HAGRYGC 576
Score = 143 bits (361), Expect = 2e-33
Identities = 155/584 (26%), Positives = 243/584 (41%), Gaps = 66/584 (11%)
Query: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
K ++C+ G+PVP W L +GT I+ +++D RY+L + + N +
Sbjct: 43 KKVALNCEVRGNPVPSYRW-LRNGTEID--LESD------YRYSLIDGTFIISNPSEAKD 93
Query: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKI 2173
G Y C A NT+G + ++ ++ G VL C P+I
Sbjct: 94 SGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPH-SPEI 152
Query: 2174 FWLLPSNDMISFSID---RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
+ N+ SF + R+ G+L I+KV+ D G Y+C+ +N + V
Sbjct: 153 IYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNT------VTNARV 206
Query: 2231 VSKP-PL------INGLYTNRTVIK----ATAVRHSKKHFDCRAEGTPSPEVMWIMPDNI 2279
+S P PL + G Y + + TA + + +C A G P P + W+ +
Sbjct: 207 LSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNG- 265
Query: 2280 FLTAPYYGSRITVHKN-GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPT 2338
Y S+ + K+ LEI NV+L D+ + C A N G++ QL+V P
Sbjct: 266 -----YIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTY---PH 317
Query: 2339 FRNPFNEKIVAQLGKSTALN--CSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSF 2396
+ N+ QL + L C G P P W L NG S PQS ++ NG
Sbjct: 318 WVEKLND---TQLDSGSPLRWECKATGKPRPTYRW-LKNGVPLS--PQSRVEMV--NGVL 369
Query: 2397 IISKTTREDAGKYRCAARNKVGYIEKLVILEI--GQKPVILTYAPGTVKGISGESLSLHC 2454
+I + DAG Y+C A NK G I L+I L T+ + + + C
Sbjct: 370 MIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIEC 429
Query: 2455 VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGH 2514
G PKP I W V + +I IL D G+L I A+ D G Y+C+ +N G
Sbjct: 430 KPQGSPKPTISWKKGDRAVRENKRIA---ILPD-GSLRILNASKSDEGKYVCRGENVFGS 485
Query: 2515 TLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT--WEMPDHSLLST 2572
I + + V P RI P R+ +T G + L+C A+ ++T W + +
Sbjct: 486 AEI-IASLSVKEPTRIELTPKRTELT-VGESIVLNCKAIHDASLDVTFYWTLKGQPI--- 540
Query: 2573 ASKERTHGSEQLHLQGT---LVIQNPQTSDSGIYKCTAKNPLGS 2613
+E E + Q + L+I+N +G Y C + S
Sbjct: 541 DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADS 584
Score = 107 bits (266), Expect = 2e-22
Identities = 100/394 (25%), Positives = 157/394 (39%), Gaps = 41/394 (10%)
Query: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDN-IFLTAPYYGSRITVHKNGTLEIRNV- 2303
+I T K +C G P P W+ I L + Y S I +GT I N
Sbjct: 34 IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI----DGTFIISNPS 89
Query: 2304 RLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDG 2363
DS + C+A N G ++ + L+ F + + G+ L CS
Sbjct: 90 EAKDSGHYQCLATNTVGS--ILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSP-- 145
Query: 2364 NPP--PEII--WILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGY 2419
PP PEII W+ F S +++ G+ ISK D G Y C +N V
Sbjct: 146 -PPHSPEIIYSWVFNEFPSFV-AEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTN 203
Query: 2420 IE------KLVILEIG----QKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP 2469
L + G +P I + P TV G ++ + C + G P P I W
Sbjct: 204 ARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKV 263
Query: 2470 SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
+GY+ + ++ L I D G Y C+A+NS G + + YP
Sbjct: 264 NGYIPSKARLR-----KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 318
Query: 2530 ITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGT 2589
+ + +G+ + C A G P+P W + + LS S+ + G
Sbjct: 319 VEKLNDTQL--DSGSPLRWECKATGKPRPTYRW-LKNGVPLSPQSRVEM-------VNGV 368
Query: 2590 LVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L+I N SD+G+Y+C A+N G+ YA+ ++++
Sbjct: 369 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 402
Score = 72.4 bits (176), Expect = 6e-12
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 17/184 (9%)
Query: 1660 IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRG 1719
+ + + + C+ G+P PTI W + + ++N R+ +LP+G+L I D G
Sbjct: 419 VTKDQEVVIECKPQGSPKPTISWKKGDRAV-----RENKRIAILPDGSLRILNASKSDEG 473
Query: 1720 QYLCSASNLFGTDHLHVTLSVVSYPPRI-LERRTKEITVHSGSTVELKCRAEGRPSPTVT 1778
+Y+C N+FG+ + +LS V P RI L + E+TV G ++ L C+A S VT
Sbjct: 474 KYVCRGENVFGSAEIIASLS-VKEPTRIELTPKRTELTV--GESIVLNCKAIHDASLDVT 530
Query: 1779 --WILANQTVVSESSQGSRQAV--VTVDGTLVLHNLSIYDRGFYKC----VASNPGGQDS 1830
W L Q + E G +++ L++ N+ + G Y C A + +
Sbjct: 531 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 590
Query: 1831 LLVK 1834
LLV+
Sbjct: 591 LLVR 594
Score = 54.7 bits (130), Expect = 1e-06
Identities = 48/191 (25%), Positives = 86/191 (45%), Gaps = 16/191 (8%)
Query: 475 ISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG 534
+ + N+T+L+ G + C G P P WL K P +S R+ + +G
Sbjct: 319 VEKLNDTQLDS----GSPLRWECKATGKPRPTYRWL-----KNGVP-LSPQSRVEM-VNG 367
Query: 535 KLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLD-- 592
L + + D G+Y C++ N A + + ++ + N + T+ + + +
Sbjct: 368 VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILAS-APTFALNQLKKTIIVTKDQEVV 426
Query: 593 LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
+ C G P +ISW G+ + ++ R +L +G+LRIL + D+G Y C N G
Sbjct: 427 IECKPQGSPKPTISWK-KGDRAVRENKRIA-ILPDGSLRILNASKSDEGKYVCRGENVFG 484
Query: 653 VDFLIFQVSVK 663
+I +SVK
Sbjct: 485 SAEIIASLSVK 495
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/183 (24%), Positives = 73/183 (39%), Gaps = 24/183 (13%)
Query: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
T G TV + C G+P P + W+ +G Y+ R L LE+ D
Sbjct: 237 TAAKGTTVKMECFALGNPVPTITWMKVNG------YIPSKAR-LRKSQAVLEIPNVQLDD 289
Query: 546 TGVYHCISSNYDDADILTYRITV------VEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
G+Y C + N + ++ V VE L + ++ G L C +TG
Sbjct: 290 AGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS--------GSPLRWECKATG 341
Query: 600 IPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQ 659
P + W+ N + S + + + NG L I V D G Y+C+A N G + +
Sbjct: 342 KPRPTYRWL---KNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAE 398
Query: 660 VSV 662
+ +
Sbjct: 399 LKI 401
Score = 43.1 bits (100), Expect = 0.004
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 36/192 (18%)
Query: 482 KLEHTVLV--GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQ 539
+L+ T++V V + C QG P P + W D + V E+ RI I G L +
Sbjct: 412 QLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA------VRENKRIAILPDGSLRIL 465
Query: 540 MADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTG 599
A D G Y C N + + ++V EP TV GE++ L C +
Sbjct: 466 NASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTV--GESIVLNCKA-- 521
Query: 600 IPDASIS----WVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDF 655
I DAS+ W + G + ++ ++ G++ + A S D
Sbjct: 522 IHDASLDVTFYWTLKGQPIDFE--------------------EEGGHFESIRAQASSADL 561
Query: 656 LIFQVSVKMKGQ 667
+I + + G+
Sbjct: 562 MIRNILLMHAGR 573
Score = 35.8 bits (81), Expect = 0.57
Identities = 48/171 (28%), Positives = 71/171 (41%), Gaps = 30/171 (17%)
Query: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAP----YVSEDGRILIDKSGKLELQMADSFDTGV 548
V LNC +G+P P W L +G+++ Y DG +I +++ D+G
Sbjct: 45 VALNCEVRGNPVPSYRW-LRNGTEIDLESDYRYSLIDGTFIISNP-------SEAKDSGH 96
Query: 549 YHCISSNYDDADILTYRITVVEPLVEAYQENGIHHT-----VFIGETLDLPC----HSTG 599
Y C+++N IL+ T L AY N T V G+ + L C HS
Sbjct: 97 YQCLATN-TVGSILSREAT----LQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHS-- 149
Query: 600 IPDASISWVI-PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
P+ SWV + + + SR G L I +V D G Y C+ N
Sbjct: 150 -PEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 199
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 155 bits (391), Expect = 6e-37
Identities = 165/630 (26%), Positives = 253/630 (40%), Gaps = 71/630 (11%)
Query: 1635 LPFD-SLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSK 1693
+P D S+ + + P I A + + + CEA GNP P+ HWTR +++K
Sbjct: 27 IPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAK 86
Query: 1694 RKQNSRVQVLPNGTLSIQ-----RVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRIL 1748
+ S + +GTL I R E + G+Y C A N FGT + VS P
Sbjct: 87 DPRVSMRR--RSGTLVIDFRSGGRPE-EYEGEYQCFARNKFGTALSNRIRLQVSKSPLWP 143
Query: 1749 ERRTKEITVHSGSTVELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVL 1807
+ + V G+ + L+C G PSP + W+ ++ +++ + S+ +G L
Sbjct: 144 KENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGH----NGDLYF 199
Query: 1808 HNLSIYD-RGFYKCVA----------SNPGGQDSLLVKIQVIAAPPVILEQ---RRQVIV 1853
N+ + D + Y C A NP L + P + Q Q+++
Sbjct: 200 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVL 259
Query: 1854 GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
G L L C A G P P + W G L +K F N L I N++ D G
Sbjct: 260 R--GMDLLLECIASGVPTPDIAWYKKGG----DLPSDKAKFENF-NKALRITNVSEEDSG 312
Query: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQI 1973
Y C+A++ GS R T+ RV + K + G+ L C A G PKP +
Sbjct: 313 EYFCLASNKMGSIRH----TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV 368
Query: 1974 MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDS-----GVYLCVARNKMGDDLIL 2028
W + + + PN + ++ +D+ VY C N+ G L
Sbjct: 369 QWMVNGEPLQSAPPN--------PNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
Query: 2029 MHVS-LRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQAD 2087
VS L + P + + + +L+ + ++DC GSP+P + W N ++
Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRW-------FKNGQGSN 472
Query: 2088 DSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSN 2147
G Y ++ NG+L + ++G YTC A N LGK E +V L V R
Sbjct: 473 LDG---GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 529
Query: 2148 KTNKRIKAGDTAVLDCEVTGDPKPK--IFWLLPSNDMISFSIDRYTFHANGSLTINKVKL 2205
++ + G T L+C V DP K + WL D I + SLTI V
Sbjct: 530 --DQVARRGTTVQLECRVKHDPSLKLTVSWL---KDDEPLYIGNRMKKEDDSLTIFGVAE 584
Query: 2206 LDSGEYVCVARNPSGDDTKMYKLDVVSKPP 2235
D G Y CVA D L V+ P
Sbjct: 585 RDQGSYTCVASTELDQDLAKAYLTVLGNCP 614
Score = 144 bits (363), Expect = 1e-33
Identities = 162/619 (26%), Positives = 256/619 (41%), Gaps = 66/619 (10%)
Query: 1936 ERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAV-------VDQQHR 1988
E P I S K V+ D +L+ C A G P P W S+ V + R
Sbjct: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
Query: 1989 VGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK 2048
G+ + + +G E+ G Y C ARNK G L + L++ + + K+
Sbjct: 96 SGTLVIDFRSGGR-----PEEYEGEYQCFARNKFGTALS-NRIRLQVSKSPLWPKENLDP 149
Query: 2049 QVLH-GKDFQVDCKAS-GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
V+ G + C G P P I W ++++M+ + +R + +NG LYF
Sbjct: 150 VVVQEGAPLTLQCNPPPGLPSPVIFW-------MSSSMEPIT---QDKRVSQGHNGDLYF 199
Query: 2107 NKVGVAE-EGDYTCYAQ----NTLGKDE---MKVHLT--VITAAPRIR--QSNKTNKRIK 2154
+ V + + + DY+C A+ +T+ + +KV T V P Q +++ +
Sbjct: 200 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVL 259
Query: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTF-HANGSLTINKVKLLDSGEYVC 2213
G +L+C +G P P I W D+ S D+ F + N +L I V DSGEY C
Sbjct: 260 RGMDLLLECIASGVPTPDIAWYKKGGDLPS---DKAKFENFNKALRITNVSEEDSGEYFC 316
Query: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMW 2273
+A N G + V + P ++ + +I A CRA G P P V W
Sbjct: 317 LASNKMGSIRHTISVRVKAAPYWLD---EPKNLILAPG---EDGRLVCRANGNPKPTVQW 370
Query: 2274 IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
++ +AP +R T+ R+ ++S A + C NE G + + VL++
Sbjct: 371 MVNGEPLQSAPPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV 428
Query: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY----QYL 2389
P +P N+ I L T L+C G+P P + W F NG S Y
Sbjct: 429 --PPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRW-------FKNGQGSNLDGGNYH 479
Query: 2390 IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGES 2449
+ NGS I +ED G Y C A N +G E V LE+ + P + P G +
Sbjct: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQVARRGTT 538
Query: 2450 LSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQ 2509
+ L C P++K T+ S D P G + ++ +L I D+G+Y C A
Sbjct: 539 VQLECRVKH--DPSLKLTV-SWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595
Query: 2510 NSVGHTLITVPVMIVAYPP 2528
+ L + ++ P
Sbjct: 596 TELDQDLAKAYLTVLGNCP 614
Score = 131 bits (329), Expect = 1e-29
Identities = 150/597 (25%), Positives = 235/597 (39%), Gaps = 47/597 (7%)
Query: 2043 KQYFRKQVLHGKD-FQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNN 2101
KQ + ++ +D ++C+A G+P P W+ + N + R R TL
Sbjct: 45 KQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR--NSRFFNIAKDPRVSMRRRSGTL--- 99
Query: 2102 GTLYFNKVGVAEE--GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTA 2159
+ F G EE G+Y C+A+N G ++ +P + N ++ G
Sbjct: 100 -VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158
Query: 2160 VLDCEVT-GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLD-SGEYVCVAR- 2216
L C G P P IFW+ S + I+ R + NG L + V L D +Y C AR
Sbjct: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217
Query: 2217 --NPSGDDTKMYKLDVVSKPPLING----LYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
+ + L V++ + +Y T +R +C A G P+P+
Sbjct: 218 HFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPD 277
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
+ W P ++ + N L I NV DS ++ C+A N+ G + + V
Sbjct: 278 IAWYKKGG---DLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333
Query: 2331 LEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLI 2390
P + + I+A G+ L C +GNP P + W++ NG + P + +
Sbjct: 334 KAA---PYWLDEPKNLILAP-GEDGRLVCRANGNPKPTVQWMV-NGEPLQSAPPNPNREV 388
Query: 2391 ASNGSFIISKTTREDAGKYRCAARNKVGYI-EKLVILEIGQKPVILTYAPGTVKGISGES 2449
A + + I T Y+C N+ GY+ + + P +L+ ++ I
Sbjct: 389 AGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 447
Query: 2450 LSLHCVSDGIPKPNIKWTMPS-GYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKA 2508
L C G P P ++W G +D G Y +++NG+L IK D+G Y C A
Sbjct: 448 TRLDCPFFGSPIPTLRWFKNGQGSNLD----GGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
Query: 2509 QNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVP--KPEITWEMPD 2566
N +G V + V P RI R P V R G QL C P K ++W D
Sbjct: 504 TNILGKAENQVR-LEVKDPTRI-YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 561
Query: 2567 HSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L G+ +L I D G Y C A L D A Y+ V+
Sbjct: 562 EPLYI--------GNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
Score = 68.2 bits (165), Expect = 1e-10
Identities = 74/303 (24%), Positives = 115/303 (37%), Gaps = 35/303 (11%)
Query: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIA 2391
E+ + PT + + + + C GNP P W N F+ +
Sbjct: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHW-TRNSRFFNIAKDPRVSMRR 94
Query: 2392 SNGSFIISKTT----REDAGKYRCAARNKVG-YIEKLVILEIGQKPVILTYAPGTVKGIS 2446
+G+ +I + E G+Y+C ARNK G + + L++ + P+ V
Sbjct: 95 RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQE 154
Query: 2447 GESLSLHC-VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD-RGNY 2504
G L+L C G+P P I W S + + + + NG L D + +Y
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDK---RVSQGHNGDLYFSNVMLQDMQTDY 211
Query: 2505 ICKAQNSVGHTL-----ITVPVMIVAYPPRITNRPPRSIVTRTGAAFQ---------LHC 2550
C A+ HT+ T+ V+ + R P + + A+ Q L C
Sbjct: 212 SCNARFHFTHTIQQKNPFTLKVLTTR---GVAERTPSFMYPQGTASSQMVLRGMDLLLEC 268
Query: 2551 VALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNP 2610
+A GVP P+I W L S +K + L I N DSG Y C A N
Sbjct: 269 IASGVPTPDIAWYKKGGDLPSDKAKFE-------NFNKALRITNVSEEDSGEYFCLASNK 321
Query: 2611 LGS 2613
+GS
Sbjct: 322 MGS 324
Score = 55.1 bits (131), Expect = 9e-07
Identities = 46/166 (27%), Positives = 76/166 (45%), Gaps = 16/166 (9%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLL-ADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
V++ L+CP G P P + W GS + + G + ++G LE++M D
Sbjct: 442 VILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------DGGNYHVYENGSLEIKMIRKED 495
Query: 546 TGVYHCISSNYDDADILTYRITVVEPL-VEAYQENGIHHTVFIGETLDLPCHSTGIPDA- 603
G+Y C+++N R+ V +P + E+ + G T+ L C P
Sbjct: 496 QGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR---GTTVQLECRVKHDPSLK 552
Query: 604 -SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAA 648
++SW + + LY +R KK + +L I V +DQG Y CVA+
Sbjct: 553 LTVSW-LKDDEPLYIGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 595
Score = 43.5 bits (101), Expect = 0.003
Identities = 40/170 (23%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 484 EHTVLVGGTVG-LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
++ +L G G L C G+P P V W++ +G +++ + + + D + Q++
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMV-NGEPLQSAPPNPNREVAGDTIIFRDTQISS 402
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
VY C +SN + ++V++ V + L C G P
Sbjct: 403 R---AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPI 459
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
++ W G + V NG+L I + +DQG Y CVA N G
Sbjct: 460 PTLRWFKNGQGSNLDGG-NYHVYENGSLEIKMIRKEDQGIYTCVATNILG 508
Score = 42.4 bits (98), Expect = 0.006
Identities = 39/194 (20%), Positives = 68/194 (35%), Gaps = 8/194 (4%)
Query: 459 TLPRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVR 518
TL R V + T VL G + L C G PTP + W G
Sbjct: 230 TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGD--- 286
Query: 519 APYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQE 578
+ D + + L + D+G Y C++SN + + I+V + +
Sbjct: 287 ---LPSDKAKFENFNKALRITNVSEEDSGEYFCLASN--KMGSIRHTISVRVKAAPYWLD 341
Query: 579 NGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPK 638
+ + GE L C + G P ++ W++ G + + + T+
Sbjct: 342 EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 401
Query: 639 DQGYYRCVAANPSG 652
+ Y+C +N G
Sbjct: 402 SRAVYQCNTSNEHG 415
Score = 42.0 bits (97), Expect = 0.008
Identities = 45/189 (23%), Positives = 75/189 (39%), Gaps = 22/189 (11%)
Query: 490 GGTVGLNC-PGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQ------MAD 542
G + L C P G P+P + W+ S P +++D R+ +G L M
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWM----SSSMEP-ITQDKRVSQGHNGDLYFSNVMLQDMQT 209
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAY------QENGIHHTVFIGETLDLPCH 596
+ + + T ++ + E Q V G L L C
Sbjct: 210 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 269
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFL 656
++G+P I+W G ++ S + K N LRI V+ +D G Y C+A+N G +
Sbjct: 270 ASGVPTPDIAWYKKGGDL--PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMG--SI 325
Query: 657 IFQVSVKMK 665
+SV++K
Sbjct: 326 RHTISVRVK 334
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 154 bits (388), Expect = 1e-36
Identities = 164/627 (26%), Positives = 253/627 (40%), Gaps = 71/627 (11%)
Query: 1635 LPFD-SLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSK 1693
+P D S+ + + P I A + + + CEA GNP P+ HWTR +++K
Sbjct: 27 IPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAK 86
Query: 1694 RKQNSRVQVLPNGTLSIQ-----RVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRIL 1748
+ S + +GTL I R E + G+Y C A N FGT + VS P
Sbjct: 87 DPRVSMRR--RSGTLVIDFRSGGRPE-EYEGEYQCFARNKFGTALSNRIRLQVSKSPLWP 143
Query: 1749 ERRTKEITVHSGSTVELKCR-AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVL 1807
+ + V G+ + L+C G PSP + W+ ++ +++ + S+ +G L
Sbjct: 144 KENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGH----NGDLYF 199
Query: 1808 HNLSIYD-RGFYKCVA----------SNPGGQDSLLVKIQVIAAPPVILEQ---RRQVIV 1853
N+ + D + Y C A NP L + P + Q Q+++
Sbjct: 200 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVL 259
Query: 1854 GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
G L L C A G P P + W G L +K F N L I N++ D G
Sbjct: 260 R--GMDLLLECIASGVPTPDIAWYKKGG----DLPSDKAKFENF-NKALRITNVSEEDSG 312
Query: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQI 1973
Y C+A++ GS R T+ RV + K + G+ L C A G PKP +
Sbjct: 313 EYFCLASNKMGSIRH----TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV 368
Query: 1974 MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDS-----GVYLCVARNKMGDDLIL 2028
W + + + PN + ++ +D+ VY C N+ G L
Sbjct: 369 QWMVNGEPLQSAPPN--------PNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
Query: 2029 MHVS-LRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQAD 2087
VS L + P + + + +L+ + ++DC GSP+P + W N ++
Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRW-------FKNGQGSN 472
Query: 2088 DSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSN 2147
G Y ++ NG+L + ++G YTC A N LGK E +V L V R
Sbjct: 473 LDG---GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 529
Query: 2148 KTNKRIKAGDTAVLDCEVTGDPKPK--IFWLLPSNDMISFSIDRYTFHANGSLTINKVKL 2205
++ + G T L+C V DP K + WL D I + SLTI V
Sbjct: 530 --DQVARRGTTVQLECRVKHDPSLKLTVSWL---KDDEPLYIGNRMKKEDDSLTIFGVAE 584
Query: 2206 LDSGEYVCVARNPSGDDTKMYKLDVVS 2232
D G Y CVA D L V++
Sbjct: 585 RDQGSYTCVASTELDQDLAKAYLTVLA 611
Score = 148 bits (373), Expect = 8e-35
Identities = 170/653 (26%), Positives = 265/653 (40%), Gaps = 66/653 (10%)
Query: 1936 ERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAV-------VDQQHR 1988
E P I S K V+ D +L+ C A G P P W S+ V + R
Sbjct: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
Query: 1989 VGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK 2048
G+ + + +G E+ G Y C ARNK G L + L++ + + K+
Sbjct: 96 SGTLVIDFRSGGR-----PEEYEGEYQCFARNKFGTALS-NRIRLQVSKSPLWPKENLDP 149
Query: 2049 QVLH-GKDFQVDCKAS-GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
V+ G + C G P P I W ++++M+ + +R + +NG LYF
Sbjct: 150 VVVQEGAPLTLQCNPPPGLPSPVIFW-------MSSSMEPIT---QDKRVSQGHNGDLYF 199
Query: 2107 NKVGVAE-EGDYTCYAQ----NTLGKDE---MKVHLT--VITAAPRIR--QSNKTNKRIK 2154
+ V + + + DY+C A+ +T+ + +KV T V P Q +++ +
Sbjct: 200 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVL 259
Query: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTF-HANGSLTINKVKLLDSGEYVC 2213
G +L+C +G P P I W D+ S D+ F + N +L I V DSGEY C
Sbjct: 260 RGMDLLLECIASGVPTPDIAWYKKGGDLPS---DKAKFENFNKALRITNVSEEDSGEYFC 316
Query: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMW 2273
+A N G + V + P ++ + +I A CRA G P P V W
Sbjct: 317 LASNKMGSIRHTISVRVKAAPYWLD---EPKNLILAPG---EDGRLVCRANGNPKPTVQW 370
Query: 2274 IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
++ +AP +R T+ R+ ++S A + C NE G + + VL++
Sbjct: 371 MVNGEPLQSAPPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV 428
Query: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY----QYL 2389
P +P N+ I L T L+C G+P P + W F NG S Y
Sbjct: 429 --PPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRW-------FKNGQGSNLDGGNYH 479
Query: 2390 IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGES 2449
+ NGS I +ED G Y C A N +G E V LE+ + P + P G +
Sbjct: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQVARRGTT 538
Query: 2450 LSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQ 2509
+ L C P++K T+ S D P G + ++ +L I D+G+Y C A
Sbjct: 539 VQLECRVK--HDPSLKLTV-SWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595
Query: 2510 NSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITW 2562
+ L + ++A TNR R L L +TW
Sbjct: 596 TELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTW 648
Score = 131 bits (329), Expect = 1e-29
Identities = 150/597 (25%), Positives = 235/597 (39%), Gaps = 47/597 (7%)
Query: 2043 KQYFRKQVLHGKD-FQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNN 2101
KQ + ++ +D ++C+A G+P P W+ + N + R R TL
Sbjct: 45 KQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR--NSRFFNIAKDPRVSMRRRSGTL--- 99
Query: 2102 GTLYFNKVGVAEE--GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTA 2159
+ F G EE G+Y C+A+N G ++ +P + N ++ G
Sbjct: 100 -VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158
Query: 2160 VLDCEVT-GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLD-SGEYVCVAR- 2216
L C G P P IFW+ S + I+ R + NG L + V L D +Y C AR
Sbjct: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217
Query: 2217 --NPSGDDTKMYKLDVVSKPPLING----LYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
+ + L V++ + +Y T +R +C A G P+P+
Sbjct: 218 HFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPD 277
Query: 2271 VMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
+ W P ++ + N L I NV DS ++ C+A N+ G + + V
Sbjct: 278 IAWYKKGG---DLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333
Query: 2331 LEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLI 2390
P + + I+A G+ L C +GNP P + W++ NG + P + +
Sbjct: 334 KAA---PYWLDEPKNLILAP-GEDGRLVCRANGNPKPTVQWMV-NGEPLQSAPPNPNREV 388
Query: 2391 ASNGSFIISKTTREDAGKYRCAARNKVGYI-EKLVILEIGQKPVILTYAPGTVKGISGES 2449
A + + I T Y+C N+ GY+ + + P +L+ ++ I
Sbjct: 389 AGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 447
Query: 2450 LSLHCVSDGIPKPNIKWTMPS-GYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKA 2508
L C G P P ++W G +D G Y +++NG+L IK D+G Y C A
Sbjct: 448 TRLDCPFFGSPIPTLRWFKNGQGSNLD----GGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
Query: 2509 QNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT--WEMPD 2566
N +G V + V P RI R P V R G QL C P ++T W D
Sbjct: 504 TNILGKAENQVRLE-VKDPTRIY-RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 561
Query: 2567 HSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
L G+ +L I D G Y C A L D A Y+ V+
Sbjct: 562 EPLYI--------GNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
Score = 123 bits (308), Expect = 3e-27
Identities = 123/494 (24%), Positives = 198/494 (40%), Gaps = 40/494 (8%)
Query: 2137 ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHA-N 2195
+T P I + + + + D +++CE G+P P W S R + +
Sbjct: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
Query: 2196 GSLTIN-----KVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT 2250
G+L I+ + + + GEY C ARN G VSK PL + V++
Sbjct: 97 GTLVIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEG 155
Query: 2251 AVRHSKKHFDCRAE-GTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSD-S 2308
A C G PSP + W+ +T R++ NG L NV L D
Sbjct: 156 A----PLTLQCNPPPGLPSPVIFWMSSSMEPITQD---KRVSQGHNGDLYFSNVMLQDMQ 208
Query: 2309 ADFICVARNEGGESVLVVQLEVLEML-------RRPTFRNP---FNEKIVAQLGKSTALN 2358
D+ C AR ++ L++L R P+F P + ++V + G L
Sbjct: 209 TDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLE 267
Query: 2359 CSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG 2418
C G P P+I W G S+ + + N + I+ + ED+G+Y C A NK+G
Sbjct: 268 CIASGVPTPDIAWYKKGGDLPSDKAKFENF----NKALRITNVSEEDSGEYFCLASNKMG 323
Query: 2419 YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQ 2478
I + + + P L P + GE L C ++G PKP ++W + + P
Sbjct: 324 SIRHTISVRVKAAPYWLD-EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP 382
Query: 2479 INGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSI 2538
+ + D T++ ++ R Y C N G+ L V ++ PPR+ + + I
Sbjct: 383 NPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLI 440
Query: 2539 VTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTS 2598
+L C G P P + W + G+ ++ G+L I+ +
Sbjct: 441 RVILYNRTRLDCPFFGSPIPTLRW------FKNGQGSNLDGGNYHVYENGSLEIKMIRKE 494
Query: 2599 DSGIYKCTAKNPLG 2612
D GIY C A N LG
Sbjct: 495 DQGIYTCVATNILG 508
Score = 90.5 bits (223), Expect = 2e-17
Identities = 79/292 (27%), Positives = 132/292 (45%), Gaps = 19/292 (6%)
Query: 1665 DAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCS 1724
D L C A GNP PT+ W + +G L N +V + T+ + +I R Y C+
Sbjct: 353 DGRLVCRANGNPKPTVQW--MVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCN 409
Query: 1725 ASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQ 1784
SN G + +SV+ PPR+L R + I V + L C G P PT+ W Q
Sbjct: 410 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 469
Query: 1785 TVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVI 1844
S+ V +G+L + + D+G Y CVA+N G+ V+++V P
Sbjct: 470 ----GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV--KDPTR 523
Query: 1845 LEQRRQVIVGTWGESLKLPCTAKGTP--QPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTL 1902
+ + + V G +++L C K P + +V W+ D +PL N + +L
Sbjct: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD----EPLYIGNR--MKKEDDSL 577
Query: 1903 YIRNLASSDRGTYECIATSSTGSERRVVMLTM--EERVTSPRIEAASQKRTE 1952
I +A D+G+Y C+A++ + LT+ ++ + R+ A + R +
Sbjct: 578 TIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPD 629
Score = 68.2 bits (165), Expect = 1e-10
Identities = 74/300 (24%), Positives = 114/300 (38%), Gaps = 29/300 (9%)
Query: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIA 2391
E+ + PT + + + + C GNP P W N F+ +
Sbjct: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRR 94
Query: 2392 SNGSFIISKTT----REDAGKYRCAARNKVGY-IEKLVILEIGQKPVILTYAPGTVKGIS 2446
+G+ +I + E G+Y+C ARNK G + + L++ + P+ V
Sbjct: 95 RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQE 154
Query: 2447 GESLSLHC-VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYD-RGNY 2504
G L+L C G+P P I W S + + + + NG L D + +Y
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDK---RVSQGHNGDLYFSNVMLQDMQTDY 211
Query: 2505 ICKAQNSVGHTLITV-PVMIVAYPPR-ITNRPPRSIVTRTGAAFQ---------LHCVAL 2553
C A+ HT+ P + R + R P + + A+ Q L C+A
Sbjct: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271
Query: 2554 GVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
GVP P+I W L S +K + L I N DSG Y C A N +GS
Sbjct: 272 GVPTPDIAWYKKGGDLPSDKAKFE-------NFNKALRITNVSEEDSGEYFCLASNKMGS 324
Score = 55.1 bits (131), Expect = 9e-07
Identities = 46/166 (27%), Positives = 76/166 (45%), Gaps = 16/166 (9%)
Query: 487 VLVGGTVGLNCPGQGDPTPHVDWLL-ADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
V++ L+CP G P P + W GS + + G + ++G LE++M D
Sbjct: 442 VILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------DGGNYHVYENGSLEIKMIRKED 495
Query: 546 TGVYHCISSNYDDADILTYRITVVEPL-VEAYQENGIHHTVFIGETLDLPCHSTGIPDA- 603
G+Y C+++N R+ V +P + E+ + G T+ L C P
Sbjct: 496 QGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR---GTTVQLECRVKHDPSLK 552
Query: 604 -SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAA 648
++SW + + LY +R KK + +L I V +DQG Y CVA+
Sbjct: 553 LTVSW-LKDDEPLYIGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 595
Score = 43.5 bits (101), Expect = 0.003
Identities = 40/170 (23%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 484 EHTVLVGGTVG-LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD 542
++ +L G G L C G+P P V W++ +G +++ + + + D + Q++
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMV-NGEPLQSAPPNPNREVAGDTIIFRDTQISS 402
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
VY C +SN + ++V++ V + L C G P
Sbjct: 403 R---AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPI 459
Query: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
++ W G + V NG+L I + +DQG Y CVA N G
Sbjct: 460 PTLRWFKNGQGSNLDGG-NYHVYENGSLEIKMIRKEDQGIYTCVATNILG 508
Score = 42.4 bits (98), Expect = 0.006
Identities = 39/194 (20%), Positives = 68/194 (35%), Gaps = 8/194 (4%)
Query: 459 TLPRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVR 518
TL R V + T VL G + L C G PTP + W G
Sbjct: 230 TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGD--- 286
Query: 519 APYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQE 578
+ D + + L + D+G Y C++SN + + I+V + +
Sbjct: 287 ---LPSDKAKFENFNKALRITNVSEEDSGEYFCLASN--KMGSIRHTISVRVKAAPYWLD 341
Query: 579 NGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPK 638
+ + GE L C + G P ++ W++ G + + + T+
Sbjct: 342 EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 401
Query: 639 DQGYYRCVAANPSG 652
+ Y+C +N G
Sbjct: 402 SRAVYQCNTSNEHG 415
Score = 42.0 bits (97), Expect = 0.008
Identities = 45/189 (23%), Positives = 75/189 (39%), Gaps = 22/189 (11%)
Query: 490 GGTVGLNC-PGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQ------MAD 542
G + L C P G P+P + W+ S P +++D R+ +G L M
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWM----SSSMEP-ITQDKRVSQGHNGDLYFSNVMLQDMQT 209
Query: 543 SFDTGVYHCISSNYDDADILTYRITVVEPLVEAY------QENGIHHTVFIGETLDLPCH 596
+ + + T ++ + E Q V G L L C
Sbjct: 210 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 269
Query: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFL 656
++G+P I+W G ++ S + K N LRI V+ +D G Y C+A+N G +
Sbjct: 270 ASGVPTPDIAWYKKGGDL--PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMG--SI 325
Query: 657 IFQVSVKMK 665
+SV++K
Sbjct: 326 RHTISVRVK 334
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,652,279
Number of Sequences: 37866
Number of extensions: 4976686
Number of successful extensions: 41076
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 413
Number of HSP's successfully gapped in prelim test: 448
Number of HSP's that attempted gapping in prelim test: 13721
Number of HSP's gapped (non-prelim): 10634
length of query: 2623
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2504
effective length of database: 13,741,464
effective search space: 34408625856
effective search space used: 34408625856
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.