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Search of human proteins with 124249396
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
(783 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 1531 0.0
gi|38044112 restin isoform b [Homo sapiens] 108 2e-23
gi|4506751 restin isoform a [Homo sapiens] 108 2e-23
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 107 3e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 106 7e-23
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 102 1e-21
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 102 1e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 102 2e-21
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 100 5e-21
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 100 7e-21
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 100 7e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 100 9e-21
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 99 2e-20
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 99 2e-20
gi|55770834 centromere protein F [Homo sapiens] 99 2e-20
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 96 1e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 96 1e-19
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 96 2e-19
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 96 2e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 95 2e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 2e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 2e-19
gi|148746195 trichohyalin [Homo sapiens] 95 3e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 95 3e-19
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 94 5e-19
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 94 5e-19
gi|21735548 centrosomal protein 2 [Homo sapiens] 94 6e-19
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 93 8e-19
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 92 1e-18
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 92 1e-18
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 1531 bits (3964), Expect = 0.0
Identities = 783/783 (100%), Positives = 783/783 (100%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG
Sbjct: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
Query: 61 ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP
Sbjct: 61 ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
Query: 121 ESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMK 180
ESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMK
Sbjct: 121 ESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMK 180
Query: 181 DEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGE 240
DEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGE
Sbjct: 181 DEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGE 240
Query: 241 VQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDS 300
VQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDS
Sbjct: 241 VQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDS 300
Query: 301 TKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQ 360
TKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQ
Sbjct: 301 TKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQ 360
Query: 361 RKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ 420
RKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ
Sbjct: 361 RKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ 420
Query: 421 VRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEK 480
VRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEK
Sbjct: 421 VRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEK 480
Query: 481 EALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGIL 540
EALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGIL
Sbjct: 481 EALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGIL 540
Query: 541 QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKEN 600
QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKEN
Sbjct: 541 QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKEN 600
Query: 601 KQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYS 660
KQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYS
Sbjct: 601 KQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYS 660
Query: 661 TEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGL 720
TEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGL
Sbjct: 661 TEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGL 720
Query: 721 VESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQDQK 780
VESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQDQK
Sbjct: 721 VESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQDQK 780
Query: 781 SEL 783
SEL
Sbjct: 781 SEL 783
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 108 bits (270), Expect = 2e-23
Identities = 148/675 (21%), Positives = 297/675 (44%), Gaps = 81/675 (12%)
Query: 3 QEKNEMFESEWSK-EREREKQLASGLDTAEKALKVESE--ELQKSKSELICLYNEVHNLP 59
+EK E+ SK ++ ++ L DT K + E + EL+ +++ + N
Sbjct: 658 KEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFT 717
Query: 60 GESESKDHFLIACDLLQRENSELETKVLKLSQEFA----QLNHFTLGGKTAPSNLITSEN 115
+ ++ + L+ D L++ +SE ++++ KL Q+ Q+ H + K A S+ +S
Sbjct: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE-KNAESSKASS-- 774
Query: 116 TCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQ 175
++ + E L T +Q E ++ L K+ +I +E E S E + S Q
Sbjct: 775 ITRELQGRELKL-TNLQENLSEVSQVKETL--EKELQILKEKFAEAS--EEAVSVQRSMQ 829
Query: 176 NRDMKDEEKEQQLTMKPEEIVRLREELSHIN----------QSLLQSQSSGDS------- 218
K +KE+Q M ++ +LRE L+ + + L++++ ++
Sbjct: 830 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 889
Query: 219 -SDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQ----ILCNSAEN-ELRYERGQNLDL 272
S D+ +Q ++L+ ++ +V++L L + L S E+ ++ E+ Q
Sbjct: 890 MSGDNSSQLTKMNDELRLKER-DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
Query: 273 KQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSI 332
K+H +EE +++ +L ++K+ S C L A Y+ + K E+L+
Sbjct: 949 KKH----EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ----- 999
Query: 333 KSQNNLQEKLVQEKSKVADAEEKILDLQRKLEH----AHKVCLTDTCISEKQQLEEKIKE 388
NLQ+ L+ + K+ A E+ L ++LE A K T Q +E+ KE
Sbjct: 1000 ----NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1055
Query: 389 ATQNEAKVKQQYQEEQQKRKLL-------YQNVDELHRQVRTLQDKENLLEMTCSQQQSR 441
T+ A ++ Q + + L +NV+EL++ L + +E + ++
Sbjct: 1056 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1115
Query: 442 IQ---QQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHV 498
Q Q+ L L+ E K E + +++ KL++E+ L + L + K + +
Sbjct: 1116 KQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1175
Query: 499 RNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQN 558
++ +E +K LQK + + +D + + +E+ +L+ + K++ +
Sbjct: 1176 KDADE----EKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV---- 1227
Query: 559 DTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLE 618
TL +K KL+ +V E + NK +SS E+++ QE+ QI FL
Sbjct: 1228 QTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQES------QIDFLN 1281
Query: 619 RIIRSIHIRRGENLK 633
+I + R+ ++LK
Sbjct: 1282 SVIVDLQ-RKNQDLK 1295
Score = 97.1 bits (240), Expect = 6e-20
Identities = 129/624 (20%), Positives = 269/624 (43%), Gaps = 79/624 (12%)
Query: 38 SEELQKSKSELICLYNEVHNLPGESESK-----DHFLIACDLLQRENSELETKVLKLSQE 92
++E++ +++L+ + E N SK D L+ + + E E KV +L
Sbjct: 643 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 702
Query: 93 FAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKE 152
A+ N T S L +E D ++ L K E ++L R+Q E
Sbjct: 703 QAKCNEQTKVIDNFTSQLKATEEKLLDLDA----LRKASSEGKSEMKKL------RQQLE 752
Query: 153 IPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQS 212
E+ +K + + + S R+++ E + + L+E LS ++Q
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQGRELK---------LTNLQENLSEVSQVKETL 803
Query: 213 QSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDL 272
+ + A+ ++ + Q V +LHQ + +L + E +LR E +++
Sbjct: 804 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE-KLR-ENLADMEA 861
Query: 273 K-QHNSLLQEENIKIKIELKHAQQKLL----DSTKMCSSLTAEYKHCQQKIKELELEVLK 327
K + +E+ IK K +L++ +++ D++ + + E + ++ ++EL+L++ K
Sbjct: 862 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 921
Query: 328 HTQS------------IKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTC 375
++ +K++ + QE + + + + E K+ DL++K+E +H C
Sbjct: 922 ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC----- 976
Query: 376 ISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDEL----HRQVRTLQDKENLL 431
Q+L+ + + AT +E K K + + Q +K L D+L LQ+ E L
Sbjct: 977 ----QELKARYERAT-SETKTKHE-EILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 432 EMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLL 491
+ + + Q E ++ +E ++ E + S ++ + +KLQ E + L+E L+
Sbjct: 1031 KQ--ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK-- 1086
Query: 492 KLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQ 551
+V N+ V+ QK++ E+E + Q ++ LQ E+ +
Sbjct: 1087 -----NVEELNKSKELLTVENQKME-EFRKEIETLKQAAAQKSQQLSALQ---EENVKLA 1137
Query: 552 DQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQEN----S 607
+++ D + ++ +E+ + QL+ K I+ D+E LQ++ S
Sbjct: 1138 EELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKD----ADEEKASLQKSISITS 1193
Query: 608 LRLTQQIGFLERIIRSIHIRRGEN 631
LT++ LE++ + + RGEN
Sbjct: 1194 ALLTEKDAELEKLRNEVTVLRGEN 1217
Score = 92.0 bits (227), Expect = 2e-18
Identities = 146/700 (20%), Positives = 292/700 (41%), Gaps = 101/700 (14%)
Query: 127 LETEIQSRKEETEELCPKLGERKQK------EIPEESVKEGSFPREGQKEEGSQQNRDMK 180
L T +++ E EL +L E K+K + EES+ +G + S+++R M
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL----EVATVSEKSRIM- 467
Query: 181 DEEKEQQLTMKPEEIVRLREELSH--------INQSLLQSQSS-GDSSDDSGAQHPSSGE 231
E E+ L ++ +E+ LR L ++ SLLQ SS + + + H
Sbjct: 468 --ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 525
Query: 232 KLKYN-------QQGEVQQLHQNLHRLQILCNSAENELRYERGQNLD------------L 272
LK + Q E++ L+ +L S +++L + +N D +
Sbjct: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 585
Query: 273 KQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIK-ELELEVLKHTQS 331
H ++E + L + + + +Y+H + ++ + + E H +
Sbjct: 586 ASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 645
Query: 332 IKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQ 391
+++ K+++EK +A LD K E H V + DT +++ Q+ E K+KE
Sbjct: 646 MEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT-LNKLQEAEIKVKELEV 701
Query: 392 NEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTC---SQQQSRIQQQEAL 448
+AK +Q K++ +L L D + L + + S+ + QQ EA
Sbjct: 702 LQAKCNEQ-------TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 754
Query: 449 LKQLEN-EKRKYDEHVKSNQ-------------ELSEKLSKLQQEKEALREEYLRLLKLL 494
KQ+++ E K E K++ L E LS++ Q KE L +E L++LK
Sbjct: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE-LQILK-- 811
Query: 495 NVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQI 554
+ E ++ V +Q+ N++ ++++ N ++ L+ + +A +
Sbjct: 812 ----EKFAEAS-EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 866
Query: 555 TAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQI 614
+ + L+ K KL+ + E ++ N ++ + + +++ ++LQ + +
Sbjct: 867 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 926
Query: 615 GFLERIIRSIHIRRGENLKEFPVPKWWHRGKL-ASLPPTKKQKEIYSTEVFTSNN--AEL 671
FL++ I + ++ ++ +E + +L L +K+ E TS+N EL
Sbjct: 927 SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME-------TSHNQCQEL 979
Query: 672 QHEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETE 731
+ E T K KH E ++ +L++E L + GL LQE E
Sbjct: 980 KARYERATSET-KTKHEEILQNLQKTLLDTED-----KLKGAREENSGL------LQELE 1027
Query: 732 EIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKET 771
E++ K+A + + + Q ++ +ASL++T
Sbjct: 1028 ELR-KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1066
Score = 62.8 bits (151), Expect = 1e-09
Identities = 93/466 (19%), Positives = 193/466 (41%), Gaps = 80/466 (17%)
Query: 295 QKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEE 354
+K+ +T + +L + +H +Q + E +LE + ++ ++++L + ++
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD---GHDQ 401
Query: 355 KILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNV 414
+L+L+ K++ QL ++ A + + ++ Q +EE++K + L V
Sbjct: 402 HVLELEAKMD----------------QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
Query: 415 DEL-----HRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQEL 469
+E +V T+ +K ++E+ R+Q+ L ++LE+ K D V + L
Sbjct: 446 EEESITKGDLEVATVSEKSRIMELE-KDLALRVQEVAELRRRLESNKPAGD--VDMSLSL 502
Query: 470 SEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKR 529
+++S LQ++ E R ++ R + L H E H ++ L +L+ E E +
Sbjct: 503 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSK 562
Query: 530 INQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTIS-S 588
+ E +D + L K KL+ + +Q + K + S
Sbjct: 563 LEHANKE--------------------NSDVIALWKSKLETAIASHQQAMEELKVSFSKG 602
Query: 589 IQSRVLYMDKENKQLQENSLRLTQQIGFLER---IIRSIHIRRGENLKEFPVPKWWHRGK 645
+ + + Q+++ L +I L+ R+ H + E L+
Sbjct: 603 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALR------------ 650
Query: 646 LASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEV-V 704
A L K+KE S E S + + + H +ME T++ + E+E+ V
Sbjct: 651 -AKLMKVIKEKE-NSLEAIRSKLDKAEDQ------------HLVEMEDTLNKLQEAEIKV 696
Query: 705 NEILPLSNSSFSGKGLVESFAS-LQETEE-IKSKEAMASSKSPEKS 748
E+ L ++++F S L+ TEE + +A+ + S KS
Sbjct: 697 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS 742
Score = 38.5 bits (88), Expect = 0.024
Identities = 57/232 (24%), Positives = 93/232 (40%), Gaps = 36/232 (15%)
Query: 10 ESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFL 69
ES++ K+ + EK + +K++ + S L + +EL L NEV L GE+ S
Sbjct: 1171 ESKFIKDADEEKA------SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1224
Query: 70 IACDLLQRENSELETKV----LKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEP 125
L+ + +LE KV L+L + QL+ +S NT + +E
Sbjct: 1225 SVVQTLESDKVKLELKVKNLELQLKENKRQLSS-------------SSGNTDTQADEDER 1271
Query: 126 ILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKE 185
E++I +L K + K K E + E + G N D D+EK+
Sbjct: 1272 AQESQIDFLNSVIVDLQRKNQDLKMK---VEMMSEAALNGNGD----DLNNYDSDDQEKQ 1324
Query: 186 QQLTMKPEEIVRLRE--ELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKY 235
+ KP + + +L Q+Q S D + H S GE+ Y
Sbjct: 1325 SK--KKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHST--HHGSRGEERPY 1372
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 108 bits (270), Expect = 2e-23
Identities = 148/675 (21%), Positives = 297/675 (44%), Gaps = 81/675 (12%)
Query: 3 QEKNEMFESEWSK-EREREKQLASGLDTAEKALKVESE--ELQKSKSELICLYNEVHNLP 59
+EK E+ SK ++ ++ L DT K + E + EL+ +++ + N
Sbjct: 693 KEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFT 752
Query: 60 GESESKDHFLIACDLLQRENSELETKVLKLSQEFA----QLNHFTLGGKTAPSNLITSEN 115
+ ++ + L+ D L++ +SE ++++ KL Q+ Q+ H + K A S+ +S
Sbjct: 753 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE-KNAESSKASS-- 809
Query: 116 TCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQ 175
++ + E L T +Q E ++ L K+ +I +E E S E + S Q
Sbjct: 810 ITRELQGRELKL-TNLQENLSEVSQVKETL--EKELQILKEKFAEAS--EEAVSVQRSMQ 864
Query: 176 NRDMKDEEKEQQLTMKPEEIVRLREELSHIN----------QSLLQSQSSGDS------- 218
K +KE+Q M ++ +LRE L+ + + L++++ ++
Sbjct: 865 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 924
Query: 219 -SDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQ----ILCNSAEN-ELRYERGQNLDL 272
S D+ +Q ++L+ ++ +V++L L + L S E+ ++ E+ Q
Sbjct: 925 MSGDNSSQLTKMNDELRLKER-DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983
Query: 273 KQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSI 332
K+H +EE +++ +L ++K+ S C L A Y+ + K E+L+
Sbjct: 984 KKH----EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ----- 1034
Query: 333 KSQNNLQEKLVQEKSKVADAEEKILDLQRKLEH----AHKVCLTDTCISEKQQLEEKIKE 388
NLQ+ L+ + K+ A E+ L ++LE A K T Q +E+ KE
Sbjct: 1035 ----NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1090
Query: 389 ATQNEAKVKQQYQEEQQKRKLL-------YQNVDELHRQVRTLQDKENLLEMTCSQQQSR 441
T+ A ++ Q + + L +NV+EL++ L + +E + ++
Sbjct: 1091 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150
Query: 442 IQ---QQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHV 498
Q Q+ L L+ E K E + +++ KL++E+ L + L + K + +
Sbjct: 1151 KQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1210
Query: 499 RNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQN 558
++ +E +K LQK + + +D + + +E+ +L+ + K++ +
Sbjct: 1211 KDADE----EKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV---- 1262
Query: 559 DTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLE 618
TL +K KL+ +V E + NK +SS E+++ QE+ QI FL
Sbjct: 1263 QTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQES------QIDFLN 1316
Query: 619 RIIRSIHIRRGENLK 633
+I + R+ ++LK
Sbjct: 1317 SVIVDLQ-RKNQDLK 1330
Score = 97.1 bits (240), Expect = 6e-20
Identities = 129/624 (20%), Positives = 269/624 (43%), Gaps = 79/624 (12%)
Query: 38 SEELQKSKSELICLYNEVHNLPGESESK-----DHFLIACDLLQRENSELETKVLKLSQE 92
++E++ +++L+ + E N SK D L+ + + E E KV +L
Sbjct: 678 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 737
Query: 93 FAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKE 152
A+ N T S L +E D ++ L K E ++L R+Q E
Sbjct: 738 QAKCNEQTKVIDNFTSQLKATEEKLLDLDA----LRKASSEGKSEMKKL------RQQLE 787
Query: 153 IPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQS 212
E+ +K + + + S R+++ E + + L+E LS ++Q
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELK---------LTNLQENLSEVSQVKETL 838
Query: 213 QSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDL 272
+ + A+ ++ + Q V +LHQ + +L + E +LR E +++
Sbjct: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE-KLR-ENLADMEA 896
Query: 273 K-QHNSLLQEENIKIKIELKHAQQKLL----DSTKMCSSLTAEYKHCQQKIKELELEVLK 327
K + +E+ IK K +L++ +++ D++ + + E + ++ ++EL+L++ K
Sbjct: 897 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 956
Query: 328 HTQS------------IKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTC 375
++ +K++ + QE + + + + E K+ DL++K+E +H C
Sbjct: 957 ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC----- 1011
Query: 376 ISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDEL----HRQVRTLQDKENLL 431
Q+L+ + + AT +E K K + + Q +K L D+L LQ+ E L
Sbjct: 1012 ----QELKARYERAT-SETKTKHE-EILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 432 EMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLL 491
+ + + Q E ++ +E ++ E + S ++ + +KLQ E + L+E L+
Sbjct: 1066 KQ--ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK-- 1121
Query: 492 KLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQ 551
+V N+ V+ QK++ E+E + Q ++ LQ E+ +
Sbjct: 1122 -----NVEELNKSKELLTVENQKME-EFRKEIETLKQAAAQKSQQLSALQ---EENVKLA 1172
Query: 552 DQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQEN----S 607
+++ D + ++ +E+ + QL+ K I+ D+E LQ++ S
Sbjct: 1173 EELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKD----ADEEKASLQKSISITS 1228
Query: 608 LRLTQQIGFLERIIRSIHIRRGEN 631
LT++ LE++ + + RGEN
Sbjct: 1229 ALLTEKDAELEKLRNEVTVLRGEN 1252
Score = 87.4 bits (215), Expect = 5e-17
Identities = 146/728 (20%), Positives = 295/728 (40%), Gaps = 122/728 (16%)
Query: 127 LETEIQSRKEETEELCPKLGERKQK------EIPEESVKEGSFPREG------------- 167
L T +++ E EL +L E K+K + EES+ +G +
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQS 472
Query: 168 ---QKEEGSQQNRDMKDE------------EKEQQLTMKPEEIVRLREELSH-------- 204
+K + + R+++D E E+ L ++ +E+ LR L
Sbjct: 473 LLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVD 532
Query: 205 INQSLLQSQSS-GDSSDDSGAQHPSSGEKLKYN-------QQGEVQQLHQNLHRLQILCN 256
++ SLLQ SS + + + H LK + Q E++ L+ +L
Sbjct: 533 MSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENE 592
Query: 257 SAENELRYERGQNLD------------LKQHNSLLQEENIKIKIELKHAQQKLLDSTKMC 304
S +++L + +N D + H ++E + L + +
Sbjct: 593 SLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 652
Query: 305 SSLTAEYKHCQQKIK-ELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKL 363
+ +Y+H + ++ + + E H + +++ K+++EK +A LD K
Sbjct: 653 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KA 709
Query: 364 EHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRT 423
E H V + DT +++ Q+ E K+KE +AK +Q K++ +L
Sbjct: 710 EDQHLVEMEDT-LNKLQEAEIKVKELEVLQAKCNEQ-------TKVIDNFTSQLKATEEK 761
Query: 424 LQDKENLLEMTC---SQQQSRIQQQEALLKQLEN-EKRKYDEHVKSNQ------------ 467
L D + L + + S+ + QQ EA KQ+++ E K E K++
Sbjct: 762 LLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKL 821
Query: 468 -ELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELR 526
L E LS++ Q KE L +E L++LK + E ++ V +Q+ N++ +
Sbjct: 822 TNLQENLSEVSQVKETLEKE-LQILK------EKFAEAS-EEAVSVQRSMQETVNKLHQK 873
Query: 527 DKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTI 586
+++ N ++ L+ + +A + + + L+ K KL+ + E ++ N +
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
Query: 587 SSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKL 646
+ + + +++ ++LQ + + FL++ I + ++ ++ +E + +L
Sbjct: 934 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 993
Query: 647 -ASLPPTKKQKEIYSTEVFTSNN--AELQHEDESVPEATEKWKHSEQMETTISDILESEV 703
L +K+ E TS+N EL+ E T K KH E ++ +L++E
Sbjct: 994 ERKLSDLEKKME-------TSHNQCQELKARYERATSET-KTKHEEILQNLQKTLLDTED 1045
Query: 704 VNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYI 763
L + GL LQE EE++ K+A + + + Q ++
Sbjct: 1046 -----KLKGAREENSGL------LQELEELR-KQADKAKAAQTAEDAMQIMEQMTKEKTE 1093
Query: 764 NVASLKET 771
+ASL++T
Sbjct: 1094 TLASLEDT 1101
Score = 52.8 bits (125), Expect = 1e-06
Identities = 95/501 (18%), Positives = 197/501 (39%), Gaps = 115/501 (22%)
Query: 295 QKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEE 354
+K+ +T + +L + +H +Q + E +LE + ++ ++++L + ++
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD---GHDQ 401
Query: 355 KILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQK-------- 406
+L+L+ K++ QL ++ A + + ++ Q +EE++K
Sbjct: 402 HVLELEAKMD----------------QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
Query: 407 -------------------------RKLLYQ--NVDELHRQ-----VRTLQDKENLLEMT 434
+ LL++ D+L R+ V T+ +K ++E+
Sbjct: 446 EEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELE 505
Query: 435 CSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLL 494
R+Q+ L ++LE+ K D V + L +++S LQ++ E R ++ R + L
Sbjct: 506 -KDLALRVQEVAELRRRLESNKPAGD--VDMSLSLLQEISSLQEKLEVTRTDHQREITSL 562
Query: 495 NVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQI 554
H E H ++ L +L+ E E ++ E
Sbjct: 563 KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE------------------ 604
Query: 555 TAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTIS-SIQSRVLYMDKENKQLQENSLRLTQQ 613
+D + L K KL+ + +Q + K + S + + + Q+++ L +
Sbjct: 605 --NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 662
Query: 614 IGFLER---IIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAE 670
I L+ R+ H + E L+ A L K+KE S E S +
Sbjct: 663 IENLQNQQDSERAAHAKEMEALR-------------AKLMKVIKEKE-NSLEAIRSKLDK 708
Query: 671 LQHEDESVPEATEKWKHSEQMETTISDILESEV-VNEILPLSNSSFSGKGLVESFAS-LQ 728
+ + H +ME T++ + E+E+ V E+ L ++++F S L+
Sbjct: 709 AEDQ------------HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK 756
Query: 729 ETEE-IKSKEAMASSKSPEKS 748
TEE + +A+ + S KS
Sbjct: 757 ATEEKLLDLDALRKASSEGKS 777
Score = 38.5 bits (88), Expect = 0.024
Identities = 57/232 (24%), Positives = 93/232 (40%), Gaps = 36/232 (15%)
Query: 10 ESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFL 69
ES++ K+ + EK + +K++ + S L + +EL L NEV L GE+ S
Sbjct: 1206 ESKFIKDADEEKA------SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1259
Query: 70 IACDLLQRENSELETKV----LKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEP 125
L+ + +LE KV L+L + QL+ +S NT + +E
Sbjct: 1260 SVVQTLESDKVKLELKVKNLELQLKENKRQLSS-------------SSGNTDTQADEDER 1306
Query: 126 ILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKE 185
E++I +L K + K K E + E + G N D D+EK+
Sbjct: 1307 AQESQIDFLNSVIVDLQRKNQDLKMK---VEMMSEAALNGNGD----DLNNYDSDDQEKQ 1359
Query: 186 QQLTMKPEEIVRLRE--ELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKY 235
+ KP + + +L Q+Q S D + H S GE+ Y
Sbjct: 1360 SK--KKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHST--HHGSRGEERPY 1407
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 107 bits (268), Expect = 3e-23
Identities = 121/556 (21%), Positives = 244/556 (43%), Gaps = 56/556 (10%)
Query: 173 SQQNRDMKDEEKEQQLT-MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGE 231
S++ R K E ++QLT P+ + S + + + ++ +++ G P +
Sbjct: 52 SKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQ 111
Query: 232 KLKYNQQGEVQ-QLHQNLHRLQIL-CNSAENELRYERGQNLDLKQHNSLLQEENIKIKIE 289
K + Q ++ +L +H ++IL C E ++ L QH E + I
Sbjct: 112 KASHQHQEALRRELEAQVHTIRILTCQKTELQMA------LYYSQHAVKQLEGEARDLIS 165
Query: 290 LKHAQQKLLDSTKMCSSLTAEYK-----HCQQKIKE---LELEVLKHT---QSIKSQN-N 337
H K + S A K + ++ KE L LE+ ++T + +K +N
Sbjct: 166 RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 225
Query: 338 LQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVK 397
LQEKL +S+ ++ + + +L+RKLE A + +E L ++++ + AK++
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS---AKLQ 282
Query: 398 QQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKR 457
Q +E + +L Q +++ RQ +Q+ E ++ +Q+ +I++QE +++ E + R
Sbjct: 283 AQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ----EQEEKIREQEEKIREQEEKMR 338
Query: 458 KYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEK-HHQQKVKLQKVK 516
+ +E + +E + ++ EKE ++ +R EK H Q+K++ Q+ K
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEK 398
Query: 517 YRLTNEVELRDKRINQ------FEDEIGILQHKI-EKEKAI---QDQITAQNDTLLLEKR 566
+ ++ ++KR Q E++I + KI E+EK + +++I Q EKR
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 458
Query: 567 KLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHI 626
+ QE++ QE+ I + ++ KE QE + +++ E +
Sbjct: 459 QEQEEMWRQEEKIR---------EQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD--- 506
Query: 627 RRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWK 686
+ E ++E W K+ +++E E +Q ++E + E EK +
Sbjct: 507 -QEEKIREQEEKMWRQEEKIREQEEKIREQE----EKIREQEEMMQEQEEKMGEQEEKMQ 561
Query: 687 HSEQMETTISDILESE 702
E+M I E E
Sbjct: 562 EQEKMRRQEEKIREQE 577
Score = 89.7 bits (221), Expect = 9e-18
Identities = 105/538 (19%), Positives = 248/538 (46%), Gaps = 72/538 (13%)
Query: 13 WSKEREREKQLASGLDTAEKALKVESEELQKSKSEL-ICLYNEVHNLPGESESKDHFLIA 71
W E E+ L S + T +K EEL K + L + LY E
Sbjct: 171 WKFAGELEQAL-SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 229
Query: 72 CDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEI 131
L++ E SE++ V +L ++ + P + +E E + ++
Sbjct: 230 LQLVESEKSEIQLNVKELKRKLERAKLLL------PQQQLQAEADHLGKELQS--VSAKL 281
Query: 132 QSRKEETEELCPKLGERKQKEI--PEESVKEGSFPREGQKEEGSQQNRDMKDEE----KE 185
Q++ EE E L +L +++++++ EE ++E + Q+E+ +Q ++++E ++
Sbjct: 282 QAQVEENE-LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 186 QQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLH 245
+++ + EE +R +EE+ + ++ E++ + ++ ++++L
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRL-----------------EEMMWEKEEKIRELE 383
Query: 246 QNLHRLQILCNSAENELRYERGQNLDLKQHNSLL---QEENIKIKIELKHAQQKLLDSTK 302
+ +H + + E E+ + + +Q QEE I+ + E Q+K + +
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443
Query: 303 MCSSLTAEYKHCQQKIKELEL-----EVLKHTQSIKSQNNL---------QEKLVQEKSK 348
E H Q+KI+E E E+ + + I+ Q + QEK+ +++ K
Sbjct: 444 -------EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK 496
Query: 349 VADAEEKILDLQRKL-EHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKR 407
V EEK+ D + K+ E K+ + I E+++ + +E + + ++ Q+ +E+ ++
Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQ 556
Query: 408 KLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ 467
+ Q +++ RQ ++++E + +Q+ +I++QE + + E + R+ +E ++ +
Sbjct: 557 EEKMQEQEKMRRQEEKIREQEEKIR----EQKEKIREQEEKIWEQEEKIREQEEMMQEQE 612
Query: 468 E-LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVE 524
E + E+ K+ +++E ++E+ ++ R EK +Q+V+L++ + ++ E
Sbjct: 613 EKMWEQEEKMCEQEEKMQEQEEKM--------RRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 85.9 bits (211), Expect = 1e-16
Identities = 78/431 (18%), Positives = 208/431 (48%), Gaps = 31/431 (7%)
Query: 166 EGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQ 225
E +K E +++K + + +L + +++ + L QS+ + ++ +
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 226 HPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYE-----RGQNLDLKQHNSLLQ 280
E+ + Q+ ++Q+ + + + E ++R + R + + ++ + +
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 281 EENIKIKIE--LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNL 338
+E + + E ++ ++ + + + L E H Q+KI+E E E + + I+ Q
Sbjct: 354 QEEMMWEKEEKMRRLEEMMWEKEEKIRELE-EKMHEQEKIREQE-EKRQEEEKIREQEKR 411
Query: 339 QE---KLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAK 395
QE K+ +++ K+ + EEKI + ++K+ + I E+++ +E+ +E + E K
Sbjct: 412 QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ-EEMWRQEEK 470
Query: 396 VKQQYQEEQQKRKL-----LYQNVDELHRQVRTLQDKENLL---EMTCSQQQSRIQQQEA 447
+++Q + +QK K+ + + +++ RQ + D+E + E +Q+ +I++QE
Sbjct: 471 IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEE 530
Query: 448 LLKQLENEKRKYDEHVKSNQE-LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHH 506
+++ E + R+ +E ++ +E + E+ K+Q++++ R+E +R EK
Sbjct: 531 KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE---------EKIREQEEKIR 581
Query: 507 QQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKR 566
+QK K+++ + ++ + E ++ +++ + + EK ++++ Q + + ++
Sbjct: 582 EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 641
Query: 567 KLQEQVIEQEQ 577
K+ EQ + Q
Sbjct: 642 KMWEQEVRLRQ 652
Score = 85.1 bits (209), Expect = 2e-16
Identities = 93/502 (18%), Positives = 232/502 (46%), Gaps = 84/502 (16%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
QEK ++ ESE S+ + K+L L+ A+ L + ++LQ +E L E+ ++ +
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKLERAK--LLLPQQQLQ---AEADHLGKELQSVSAKL 281
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPES 122
+++ + +L R N + E K+ + ++ +
Sbjct: 282 QAQ---VEENELWNRLNQQQEEKMWRQEEKIQE--------------------------- 311
Query: 123 NEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDE 182
E +IQ ++E+ E K+ E+++K +E + +KEE ++ +M E
Sbjct: 312 ----WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM-------WEKEEKMRRQEEMMWE 360
Query: 183 EKE-----QQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLK-YN 236
++E +++ + EE +R EE H + + + + + Q ++ K +
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 420
Query: 237 QQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQK 296
Q+ ++++ + + E E + R Q + + + +EE + + E+ ++K
Sbjct: 421 QEEKIREQEEKIR---------EQEKKMWR-QEEKIHEQEKIREEEKRQEQEEMWRQEEK 470
Query: 297 LLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQ----NNLQEKLVQEKSKVADA 352
+ + ++ E H Q+KI++ E +V + + + Q +EK+ +++ K+ +
Sbjct: 471 IREQEEIWRQ--KEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ 528
Query: 353 EEKILDLQRKL--------EHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQ 404
EEKI + + K+ E K+ + + E++++ + ++ + E K+++Q ++ +
Sbjct: 529 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIR 588
Query: 405 QKRKLLYQNVDELHRQVRTLQDKENLL----EMTCSQQQSRIQQQEALLKQLENEKRKYD 460
++ + +++ +++ Q +Q++E + E C Q++ +Q+E + +Q E++ ++
Sbjct: 589 EQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ---EEKMWE 645
Query: 461 EHVKSNQELSEKLSKLQQEKEA 482
+ V+ Q+ EK+ + Q+ EA
Sbjct: 646 QEVRLRQQ-EEKMQEHQEHLEA 666
Score = 50.8 bits (120), Expect = 5e-06
Identities = 70/379 (18%), Positives = 164/379 (43%), Gaps = 43/379 (11%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
QE+ E + K RE+E+++ ++ + E EE + + E++ E
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRR-----QEEMMWEKEEKMRRQEEMMW----------EK 361
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFT-LGGKTAPSNLITSENTCKDPE 121
E K L+ E E K+ +L ++ + K I + ++ E
Sbjct: 362 EEKMR------RLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 415
Query: 122 SNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKD 181
+ E +I+ ++E+ E K+ +++K +E ++E R+ Q+E Q+ + +
Sbjct: 416 AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE-KRQEQEEMWRQEEKIREQ 474
Query: 182 EE--------KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKL 233
EE EQ+ K EE V +EE H + ++ Q + + EK+
Sbjct: 475 EEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQE--EKI 532
Query: 234 KYNQQGEVQQLHQNLHRLQILCNSAENELRYE---RGQNLDLKQHNSLLQEENIKIKIE- 289
+ Q+ ++++ + + + E +++ + R Q +++ ++E+ KI+ +
Sbjct: 533 R-EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQE 591
Query: 290 --LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKS 347
+ ++K+ + +M + ++K+ E E ++ + + ++ Q +EK+ +++
Sbjct: 592 EKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ---EEKMWEQEV 648
Query: 348 KVADAEEKILDLQRKLEHA 366
++ EEK+ + Q LE A
Sbjct: 649 RLRQQEEKMQEHQEHLEAA 667
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 106 bits (265), Expect = 7e-23
Identities = 135/649 (20%), Positives = 284/649 (43%), Gaps = 74/649 (11%)
Query: 173 SQQNRDMKDEEKEQQLT-MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGE 231
S++ R K E ++QLT P+ + S + + + ++ +++ G P +
Sbjct: 52 SKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQ 111
Query: 232 KLKYNQQGEVQ-QLHQNLHRLQIL-CNSAENELRYERGQNLDLKQHNSLLQEENIKIKIE 289
K + Q ++ +L +H ++IL C E ++ L QH E + I
Sbjct: 112 KASHQHQEALRRELEAQVHTIRILTCQKTELQMA------LYYSQHAVKQLEGEARDLIS 165
Query: 290 LKHAQQKLLDSTKMCSSLTAEYK-----HCQQKIKE---LELEVLKHT---QSIKSQN-N 337
H K + S A K + ++ KE L LE+ ++T + +K +N
Sbjct: 166 RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 225
Query: 338 LQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVK 397
LQEKL +S+ ++ + + +L+RKLE A + +E L ++++ + AK++
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS---AKLQ 282
Query: 398 QQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKR 457
Q +E + +L Q +++ RQ +Q+ E ++ +Q+ +I++QE +++ E + R
Sbjct: 283 AQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ----EQEEKIREQEEKIREQEEKMR 338
Query: 458 KYDEHVKSNQE--------LSEKLSKLQQEKEAL--REEYLR----LLKLLNVHVRNYNE 503
+ +E + +E + EK K+++++E + +EE +R ++ +R E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398
Query: 504 K-HHQQKVKLQKVKYRLTNEVELRDKRINQ------FEDEIGILQHKI-EKEKAI---QD 552
K H Q+K++ Q+ K + ++ ++KR Q E++I + KI E+EK + ++
Sbjct: 399 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 458
Query: 553 QITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQ 612
+I Q EKR+ QE++ QE+ IH + ++ KE QE +R +
Sbjct: 459 KIHEQEKIREEEKRQEQEEMWRQEEKIH---------EQEEIWRQKEKMHEQEEKIRKQE 509
Query: 613 Q-IGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAEL 671
+ + E IR + E ++E W K+ ++Q+E++ E ++
Sbjct: 510 EKVWRQEEKIR----EQEEKIREQEEKMWRQEEKI------REQEEMWREEEKMHEQEKI 559
Query: 672 QHEDESVPEATEKWKHSEQMETTISDI-LESEVVNEILPLSNSSFSGKGLVESFASLQET 730
E++ + + W+ E++ + + E + E E QE
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEE 619
Query: 731 EEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQDQ 779
+ + +E + + + E + Q + G ++ +QEQ++
Sbjct: 620 KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 668
Score = 101 bits (252), Expect = 2e-21
Identities = 120/627 (19%), Positives = 290/627 (46%), Gaps = 80/627 (12%)
Query: 13 WSKEREREKQLASGLDTAEKALKVESEELQKSKSEL-ICLYNEVHNLPGESESKDHFLIA 71
W E E+ L S + T +K EEL K + L + LY E
Sbjct: 171 WKFAGELEQAL-SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 229
Query: 72 CDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEI 131
L++ E SE++ V +L ++ + P + +E E + ++
Sbjct: 230 LQLVESEKSEIQLNVKELKRKLERAKLLL------PQQQLQAEADHLGKELQS--VSAKL 281
Query: 132 QSRKEETEELCPKLGERKQKEI--PEESVKEGSFPREGQKEEGSQQNRDMKDEE----KE 185
Q++ EE E L +L +++++++ EE ++E + Q+E+ +Q ++++E ++
Sbjct: 282 QAQVEENE-LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 186 QQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLH 245
+++ + EE +R +EE+ + ++ Q + + E++ + ++ ++++L
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ---EEMMWEKEEKIRELE 397
Query: 246 QNLHRLQILCNSAENELRYERGQNLDLKQHNSLL---QEENIKIKIELKHAQQKLLDSTK 302
+ +H + + E E+ + + +Q QEE I+ + E Q+K + +
Sbjct: 398 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 457
Query: 303 MCSSLTAEYKHCQQKIKELEL-----EVLKHTQSIKSQNNL---QEKLVQEKSKVADAEE 354
E H Q+KI+E E E+ + + I Q + +EK+ +++ K+ EE
Sbjct: 458 -------EKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 355 KILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNV 414
K+ + K+ +++++ E+ ++ + E K+++Q + +++ K+ Q
Sbjct: 511 KVWRQEEKIRE------------QEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK 558
Query: 415 DELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHV-KSNQELSEKL 473
+ + +DK E +Q+ ++ +QE +++ E ++++ +E + K +++ E+
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618
Query: 474 SKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQF 533
K+Q+++E +RE+ +R E +Q+ K+ + + ++ + ++++ +
Sbjct: 619 EKIQEQEEKIREQ--------EEKIREQEEMTQEQEEKMGEQEEKMCEQ----EEKMQEQ 666
Query: 534 EDEIGILQHKI-EKEKAIQDQ---ITAQNDTLLLEKRKL---QEQVIEQEQLIHSNKWTI 586
E+ + + KI E+EK I++Q I Q + + ++ K+ +E++ EQE+
Sbjct: 667 EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE--------- 717
Query: 587 SSIQSRVLYMDKENKQLQENSLRLTQQ 613
+Q + M ++ +++ E +RL QQ
Sbjct: 718 -KMQEQEEKMRRQEEKMWEQEVRLRQQ 743
Score = 97.1 bits (240), Expect = 6e-20
Identities = 98/545 (17%), Positives = 252/545 (46%), Gaps = 65/545 (11%)
Query: 179 MKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQ 238
++ E+ E QL +K L+ +L L Q Q ++ D G + S KL+ Q
Sbjct: 233 VESEKSEIQLNVK-----ELKRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKLQ--AQ 284
Query: 239 GEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIE-LKHAQQKL 297
E +L L N + E + + + + + QEE I+ + E ++ ++K+
Sbjct: 285 VEENELWNRL-------NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 298 LDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKIL 357
+M + + ++ + E E ++ + + + + +EK+ +++ + + EEKI
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK---EEKMRRQEEMMWEKEEKIR 394
Query: 358 DLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQN----------EAKVKQQYQEEQQKR 407
+L+ K+ K+ + EK+Q EEKI+E + E K+++Q ++ +++
Sbjct: 395 ELEEKMHEQEKIREQE----EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 408 KLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ 467
K +++ +++H Q + ++++ + +Q+ +I +QE + +Q E + ++ K +
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 468 ELSEKLSKLQQEKEALREEYLRL------LKLLNVHVRNYNEKHHQQKVKLQKVKYRLTN 521
++ + K+++++E +RE+ ++ ++ R + H Q+K+ ++ + +
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQED 570
Query: 522 EVELRDKRINQFEDEIGILQHKI----EKEKAIQDQITAQNDTLLLEKRKLQEQ------ 571
++ ++++I + E+++ + KI EK + ++++ Q + + ++ K+QEQ
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 572 ----VIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIH-- 625
+ EQE++ + + + ++ +++ ++ +E R ++I E+ IR
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Query: 626 IRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKW 685
IR E + + K W +++K E +++ ++E + E +
Sbjct: 691 IREQEEMMQEQEEKMWE----------QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Query: 686 KHSEQ 690
+ E+
Sbjct: 741 RQQEE 745
Score = 93.6 bits (231), Expect = 6e-19
Identities = 108/582 (18%), Positives = 271/582 (46%), Gaps = 73/582 (12%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
QEK ++ ESE S+ + K+L L+ A+ L + ++LQ +E L E+ ++ +
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKLERAK--LLLPQQQLQ---AEADHLGKELQSVSAKL 281
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPES 122
+++ + +L R N + E K+ + ++ + K E
Sbjct: 282 QAQ---VEENELWNRLNQQQEEKMWRQEEKIQEWEE-------------------KIQEQ 319
Query: 123 NEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPRE----GQKEEGSQQNRD 178
E I E E + R++E + R+Q+E+ E KE R+ +KEE ++ +
Sbjct: 320 EEKIREQEEKIREQEEK-------MRRQEEMMWE--KEEKMRRQEEMMWEKEEKMRRQEE 370
Query: 179 MKDEEKE-----QQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKL 233
M E++E +++ + EE +R EE H + + + + + Q ++
Sbjct: 371 MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 430
Query: 234 K-YNQQGEVQQLHQNLHRLQILCNSAENELRYE---RGQNLDLKQHNSLLQEENIKIKIE 289
K + Q+ ++++ + + + E ++ + R + +Q QEE I + E
Sbjct: 431 KMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEE 490
Query: 290 LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKV 349
+ ++K+ + + + ++KI+E E ++ + + + QE+ ++E+ ++
Sbjct: 491 IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR----QEEKIREQEEM 546
Query: 350 ADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKL 409
EEK+ + ++ E + D +++++ E+ ++ + E K+++Q ++ Q++ +
Sbjct: 547 WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606
Query: 410 LYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHV-KSNQE 468
+++ +++ Q +Q++E + +Q+ +I++QE + ++ E + + +E + + ++
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIR----EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 662
Query: 469 LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDK 528
+ E+ + +++E +RE+ + +R EK +Q+ +Q+ + ++ E +K
Sbjct: 663 MQEQEETMWRQEEKIREQEKK--------IREQEEKIREQEEMMQEQEEKMW---EQEEK 711
Query: 529 RINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQE 570
Q E +Q + EK + ++++ Q L ++ K+QE
Sbjct: 712 MCEQEEK----MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 80.1 bits (196), Expect = 7e-15
Identities = 82/468 (17%), Positives = 217/468 (46%), Gaps = 45/468 (9%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEV----HNL 58
QE+ E + K RE+E+++ ++ + E EE + + E++ E +
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRR-----QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 371
Query: 59 PGESESKDHFLIACDLLQRENS---ELETKVLKLSQEFAQLNHFT-LGGKTAPSNLITSE 114
E E K ++R+ E E K+ +L ++ + K I +
Sbjct: 372 MWEKEEK---------MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422
Query: 115 NTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQ 174
++ E+ E +I+ ++E+ E K+ +++K +E ++E R+ Q+E Q
Sbjct: 423 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE-KRQEQEEMWRQ 481
Query: 175 QNRDMKDEE--KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEK 232
+ + + EE ++++ + EE +R +EE + ++ Q + ++
Sbjct: 482 EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR----QE 537
Query: 233 LKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENI-KIKIELK 291
K +Q E+ + + +H + + E E R E+ + ++ QEE + + + +++
Sbjct: 538 EKIREQEEMWREEEKMHEQEKIW---EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR 594
Query: 292 HAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVAD 351
++K + + + + ++KI+E E ++ + + I+ Q + + +++ K+ +
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ---EQEEKMGE 651
Query: 352 AEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLY 411
EEK+ + + K++ +T +++++ E+ K+ + E K+++Q + Q++ + ++
Sbjct: 652 QEEKMCEQEEKMQEQE-----ETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 706
Query: 412 QNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKY 459
+ +++ Q +Q++E + +Q+ ++ +QE L+Q E + +++
Sbjct: 707 EQEEKMCEQEEKMQEQEEKMR----RQEEKMWEQEVRLRQQEEKMQEH 750
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 102 bits (255), Expect = 1e-21
Identities = 137/693 (19%), Positives = 312/693 (45%), Gaps = 95/693 (13%)
Query: 13 WSKEREREKQLASGLDTAEKALKVESEELQKSKSEL-ICLYNEVHNLPGESESKDHFLIA 71
W E ++ L S + T K EEL K + L + LY I
Sbjct: 175 WHFAGELQRAL-SAVSTRHKKADRYIEELTKERDALSLELYRNT--------------IT 219
Query: 72 CDLLQRENSELETKVLKLSQEFA--QLNHFTLGGKTAPSNLITSENTCKDPESNEPILET 129
+ L+++N+EL+ K+ E + QLN L K + + P+ L+
Sbjct: 220 NEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLL-------PQVQTNTLQE 272
Query: 130 EIQSRKEETEELCPKLGERKQKEI-PEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQL 188
E+ ++EE E K+ ++++K EE ++E Q+E+ +Q + ++++EKE +
Sbjct: 273 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR- 331
Query: 189 TMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSS---GEKLKYNQQGEVQQLH 245
+ E+ +R ++EL + + + + ++ + E+ + Q+ ++++
Sbjct: 332 --EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 246 QNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCS 305
Q + + E +E+ + L K+ + ++E + ++E ++K+ + K
Sbjct: 390 QKMRD--------QEERMWEQDERLREKEER-MREQEKMWEQVEKMREEKKMQEQEKKTR 440
Query: 306 SLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEH 365
+ + +++I+E E ++ + ++++ Q +EK+ +++ + + EEK QR E
Sbjct: 441 DQEEKMQE-EERIREREKKMREEEETMREQ---EEKMQKQEENMWEQEEKEWQQQRLPEQ 496
Query: 366 AHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQ 425
K+ E+++++E+ ++ + E K++ Q + Q++K+ Q +++ Q +
Sbjct: 497 KEKLW-------EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ--EKMREQEDQMW 547
Query: 426 DKENLLEMTCSQQQSRIQQQEALLKQL-ENEKRKYDEHVKSNQE--LSEKLSKLQQEKEA 482
++E + Q+Q Q+E + K+ E EK+ +D+ K +E + E+ K+++E+E
Sbjct: 548 EQEEKMR---DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604
Query: 483 LREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQH 542
+RE+ EK +Q+ K+Q+ + ++ + E ++ + E+++ +
Sbjct: 605 MREQ---------------EEKMQEQEEKMQEQEEKMWEQEE----KMQEQEEKMWEQEE 645
Query: 543 KI--EKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKEN 600
K+ ++EK + Q + L E K+QEQ QEQ W ++ + ++E
Sbjct: 646 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ--EEKIWEQEKMEKKT--QEQEK 701
Query: 601 KQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYS 660
K + +R + + E+ +R E ++E K+ ++++E++
Sbjct: 702 KTWDQEKMREEESMREREKKMRE----EEEMMREQEEKMQEQEEKMQ-----EQEEEMWE 752
Query: 661 TEVFTSNNAELQHEDESVPEATEK-WKHSEQME 692
E E E + +PE EK W+H + E
Sbjct: 753 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
Score = 96.3 bits (238), Expect = 1e-19
Identities = 102/565 (18%), Positives = 261/565 (46%), Gaps = 54/565 (9%)
Query: 251 LQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKL-----LDSTKMCS 305
L++ N+ NE ++ N +L++ L + E +I++ +K ++KL L +
Sbjct: 211 LELYRNTITNEELKKK--NAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN 268
Query: 306 SLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEH 365
+L E +++++E E ++ K + + Q +E+L +++ K+ + EEK+ +++L
Sbjct: 269 TLQEEMWRQEEELREQEKKIRKQEEKMWRQ---EERLREQEGKMREQEEKMWRQEKRLRE 325
Query: 366 AHKVCLTDT--------CISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDEL 417
K +++Q++E+ ++ + E K+++Q ++ ++ + L++ ++
Sbjct: 326 QEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 418 HRQVRTLQDKENLL---EMTCSQQQSRIQQQEALLKQLEN--EKRKYDEHVKSNQELSEK 472
Q + ++D+E + + +++ R+++QE + +Q+E E++K E K ++ EK
Sbjct: 386 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
Query: 473 LS----------KLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNE 522
+ K+++E+E +RE+ ++ K ++ QQ++ QK K +
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 523 VELRDKRINQFEDEIGILQHKIEKEKAI--QDQITAQNDTLLLEKRKLQEQVIEQEQLIH 580
++ ++++I + E++I + +EK + Q+++ Q D + ++ K+++Q EQ+
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ--EQKMWDQ 563
Query: 581 SNKWTISSIQSRVLYMDKENKQLQENSLR-LTQQIGFLERIIRSIHIR---RGENLKEFP 636
+ + + D+E K +E +R +++ E ++R + + E ++E
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Query: 637 VPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEK-WKHSEQMETTI 695
W K+ +++++++ E E E + +PE EK W+H + E
Sbjct: 624 EKMWEQEEKM-----QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678
Query: 696 SDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVCS 755
E ++ + K E + E+++ +E+M + + E ++
Sbjct: 679 MQEQEEKIWEQ-------EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731
Query: 756 QNSEAGYINVASLKETHGIQEQDQK 780
Q + ++ + EQ++K
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEK 756
Score = 79.7 bits (195), Expect = 1e-14
Identities = 117/593 (19%), Positives = 264/593 (44%), Gaps = 95/593 (16%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
M +++ +M+E E K RE+E+++ + + K E+ QK + + ++ + L
Sbjct: 350 MQEQEEKMWEQE-EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE 408
Query: 61 ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
+ E RE ++ +V K+ +E + E +D
Sbjct: 409 KEER-----------MREQEKMWEQVEKMREE---------------KKMQEQEKKTRDQ 442
Query: 121 ESN----EPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQN 176
E E I E E + R+EE E + E+ QK+ EE++ E +E Q++ +Q
Sbjct: 443 EEKMQEEERIREREKKMREEE--ETMREQEEKMQKQ--EENMWEQE-EKEWQQQRLPEQK 497
Query: 177 RDMKDEEKEQQLTMK---PEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKL 233
+ ++EK Q+ K EE +R +EE+ + + + + + D Q EK+
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE----EKM 553
Query: 234 KYNQQ---GEVQQLHQNLHRLQILCNSAENELRYE---RGQNLDLKQHNSLLQEENIKIK 287
+ +Q + +++ + + E ++R E R + +++ +++E+ K
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK-- 611
Query: 288 IELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNL---QEKL-- 342
++ ++K+ + + + + ++K+ E E ++ + + + Q L +EKL
Sbjct: 612 --MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Query: 343 ---VQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEAT--------- 390
+QE+ K+ + EEKI + Q K+E + T EK + EE ++E
Sbjct: 670 HEKMQEQEKMQEQEEKIWE-QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 391 ---------QNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSR 441
+ E K+++Q +E ++ + +++ +++ Q R + KE L E Q+Q +
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 442 IQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNY 501
I +QE ++ E + R +E ++ +E + Q+EK +EE +
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEE----KMRGQEEKMWGQEE----------KMWGQ 834
Query: 502 NEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKI-EKEKAIQDQ 553
EK Q+ K+ + ++ +++ +++++ + E+++ + K+ E+E+ ++ Q
Sbjct: 835 EEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Score = 69.7 bits (169), Expect = 1e-11
Identities = 86/492 (17%), Positives = 208/492 (42%), Gaps = 45/492 (9%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
QEK + E +E ER ++ + E+ ++ + E++QK + + +
Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 494
Query: 63 ESKDHFLIACDLLQRENS--ELETKVLKLSQEFAQLNHFTLGGKTAPSN--LITSENTCK 118
E K+ + ++E E E K+ + + Q K + E +
Sbjct: 495 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 554
Query: 119 DPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRD 178
D E E ++ + +E E+ K ++++K EE ++E ++ ++EE + ++
Sbjct: 555 DQEQKMWDQEERMEKKTQEQEK---KTWDQEEKMREEERMRERE--KKMREEEEMMREQE 609
Query: 179 MKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQ 238
K +E+E+++ + E++ E++ Q + + + Q E+ + +Q
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEEKMQE------QEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
Query: 239 GEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLL 298
E H+ + + + E E+ + +Q +E ++ + ++ ++K+
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723
Query: 299 DSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILD 358
+ +M + + ++K++E E E++ +++ K+ + EEK+ +
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQE-----------------EEMWEQEEKMWEQEEKMWE 766
Query: 359 LQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELH 418
QR E K+ EK Q +EKI E E K++ Q ++ + + + + +++
Sbjct: 767 QQRLPEQKEKLWE-----HEKMQEQEKIWE---QEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Query: 419 RQVRTLQDKENLL----EMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLS 474
Q + +E + E Q++ Q+E + ++++ ++ K E + + EK+
Sbjct: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMR 878
Query: 475 KLQQEKEALREE 486
+ Q+EK +EE
Sbjct: 879 E-QEEKMRGQEE 889
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 102 bits (255), Expect = 1e-21
Identities = 118/539 (21%), Positives = 242/539 (44%), Gaps = 64/539 (11%)
Query: 173 SQQNRDMKDEEKEQQLT-MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGE 231
S++ R K E ++QLT P+ + S + + + ++ +++ G P +
Sbjct: 113 SKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQ 172
Query: 232 KLKYNQQGEVQ-QLHQNLHRLQIL-CNSAENELRYERGQNLDLKQHNSLLQEENIKIKIE 289
K + Q ++ +L +H ++IL C E ++ L QH E + I
Sbjct: 173 KASHQHQEALRRELEAQVHTIRILTCQKTELQMA------LYYSQHAVKQLEGEARDLIS 226
Query: 290 LKHAQQKLLDSTKMCSSLTAEYK-----HCQQKIKE---LELEVLKHT---QSIKSQN-N 337
H K + S A K + ++ KE L LE+ ++T + +K +N
Sbjct: 227 RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 286
Query: 338 LQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVK 397
LQEKL +S+ ++ + + +L+RKLE A + +E L ++++ + AK++
Sbjct: 287 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS---AKLQ 343
Query: 398 QQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKR 457
Q +E + +L Q +++ RQ +Q+ E ++ +Q+ +I++QE +++ E + R
Sbjct: 344 AQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ----EQEEKIREQEEKIREQEEKMR 399
Query: 458 KYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEK-HHQQKVKLQKVK 516
+ +E + +E + ++ EKE ++ +R EK H Q+K++ Q+ K
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 459
Query: 517 YRLTNEVELRDKRINQFEDEIGILQHKI-EKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ 575
+ ++ ++KR Q E ++ + KI E+E+ I++Q +E++ Q
Sbjct: 460 RQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQ---------------EEKMWRQ 503
Query: 576 EQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIR---SIHIRRGENL 632
E+ IH Q ++ ++E +Q QE R ++I E I R IH + E +
Sbjct: 504 EEKIHE--------QEKI--REEEKRQEQEEMWRQEEKIREQEEIWRQKEKIH-EQEEKI 552
Query: 633 KEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQM 691
++ W K+ +++E E +++ ++E + E EK + E+M
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQE----EKVWRQEEKIREQEEKIREQEEKIREQEEM 607
Score = 94.4 bits (233), Expect = 4e-19
Identities = 111/524 (21%), Positives = 246/524 (46%), Gaps = 49/524 (9%)
Query: 13 WSKEREREKQLASGLDTAEKALKVESEELQKSKSEL-ICLYNEVHNLPGESESKDHFLIA 71
W E E+ L S + T +K EEL K + L + LY E
Sbjct: 232 WKFAGELEQAL-SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 290
Query: 72 CDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEI 131
L++ E SE++ V +L ++ + P + +E E + ++
Sbjct: 291 LQLVESEKSEIQLNVKELKRKLERAKLLL------PQQQLQAEADHLGKELQS--VSAKL 342
Query: 132 QSRKEETEELCPKLGERKQKEI--PEESVKEGSFPREGQKEEGSQQNRDMKDEE----KE 185
Q++ EE E L +L +++++++ EE ++E + Q+E+ +Q ++++E ++
Sbjct: 343 QAQVEENE-LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 186 QQLTMKPEEIVRLREELSHINQSLLQSQSS--GDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
+++ + EE +R +EE+ + ++ Q + + E+ K +Q E +Q
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 461
Query: 244 LHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELK-HAQQKLLDSTK 302
+ + + E E + R + +Q + ++E + E K H Q+K+ + K
Sbjct: 462 EEEKIREQE---KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518
Query: 303 MCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRK 362
E ++KI+E E E+ + + I Q +EK+ +++ K+ EEK+ D + K
Sbjct: 519 RQEQ--EEMWRQEEKIREQE-EIWRQKEKIHEQ---EEKIRKQEEKMWRQEEKMHDQEEK 572
Query: 363 L-EHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQV 421
+ E KV + I E+ EEKI+E E K+++Q + Q++ + + + +++ Q
Sbjct: 573 IREQEEKVWRQEEKIREQ---EEKIRE---QEEKIREQEEMTQEQEEKMGEQEEKMCEQE 626
Query: 422 RTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQE-LSEKLSKLQQEK 480
+Q++E + +Q+ +I++QE +++ E + R+ +E ++ +E + E+ K+ +++
Sbjct: 627 EKMQEQEEKMR----RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 682
Query: 481 EALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVE 524
E ++E+ ++ R EK +Q+V+L++ + ++ E
Sbjct: 683 EKMQEQEEKM--------RRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 90.1 bits (222), Expect = 7e-18
Identities = 105/496 (21%), Positives = 229/496 (46%), Gaps = 55/496 (11%)
Query: 3 QEKNEMFESEWSKER-----EREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHN 57
++K + + E +KER E + + + EK K++ E+LQ +SE + V
Sbjct: 249 KKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ-EKLQLVESEKSEIQLNVKE 307
Query: 58 LPGESESKDHFLIACDLLQRENSELETKVLKLSQEF-AQLNHFTLGGKTAPSNLITSENT 116
L + E + L+ LQ E L ++ +S + AQ+ L N + +
Sbjct: 308 LKRKLE-RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW------NRLNQQQE 360
Query: 117 CKDPESNEPILETE--IQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQ 174
K E I E E IQ ++E+ E K+ E+++K +E + +KEE +
Sbjct: 361 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM-------WEKEEKMR 413
Query: 175 QNRDMKDEEKE-----QQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSS 229
+ +M E++E +++ + EE +R EE H + + + + + Q
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 473
Query: 230 GEKLKY--------NQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLD--LKQHNSLL 279
++ K Q+ ++++ + + R + + E E+ Q + +Q +
Sbjct: 474 EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 533
Query: 280 QEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQ-KIKELELEVLKHTQSIKSQNNL 338
++E I + E H Q++ + + E H Q+ KI+E E +V + + I+ Q
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ--- 590
Query: 339 QEKLVQEKSKVADAEEKILDLQRKL-EHAHKVCLTDTCISEKQQL----EEKIKEAT--- 390
+EK+ +++ K+ + EE + + K+ E K+C + + E+++ EEKI+E
Sbjct: 591 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKI 650
Query: 391 -QNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALL 449
+ E K+++Q + Q++ + +++ +++ Q +Q++E + +Q+ ++ +QE L
Sbjct: 651 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR----RQEEKMWEQEVRL 706
Query: 450 KQLENEKRKYDEHVKS 465
+Q E + +++ EH+++
Sbjct: 707 RQQEEKMQEHQEHLEA 722
Score = 86.3 bits (212), Expect = 1e-16
Identities = 70/393 (17%), Positives = 194/393 (49%), Gaps = 26/393 (6%)
Query: 242 QQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDST 301
QQL L S +L+ + +N + N +E+ + + +++ ++K+ +
Sbjct: 322 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 381
Query: 302 KMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNL----QEKLVQEKSKVADAEEKIL 357
+ + + ++K++ E + + + ++ Q + +EK+ +++ + + EEKI
Sbjct: 382 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 358 DLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQN----------EAKVKQQYQEEQQKR 407
+L+ K+ K+ + EK+Q EEKI+E + E K+++Q ++ +++
Sbjct: 442 ELEEKMHEQEKIREQE----EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 497
Query: 408 KLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ 467
+ +++ +++H Q + ++++ + +Q+ +I++QE + +Q E + ++ K +
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEE 557
Query: 468 ELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRD 527
++ + K+ ++E +RE+ ++ + +R EK +Q+ K+++ + + E
Sbjct: 558 KMWRQEEKMHDQEEKIREQEEKVWR-QEEKIREQEEKIREQEEKIREQEEMTQEQEEKMG 616
Query: 528 KRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQ---VIEQEQLIHSNKW 584
++ + ++ +Q + EK + +++I Q + ++ K++EQ + EQE+ + +
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 676
Query: 585 TI----SSIQSRVLYMDKENKQLQENSLRLTQQ 613
+ +Q + M ++ +++ E +RL QQ
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 709
Score = 84.0 bits (206), Expect = 5e-16
Identities = 79/424 (18%), Positives = 204/424 (48%), Gaps = 22/424 (5%)
Query: 166 EGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQ 225
E +K E +++K + + +L + +++ + L QS+ + ++ +
Sbjct: 295 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 354
Query: 226 HPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYE------RGQNLDLKQHNSLL 279
E+ + Q+ ++Q+ + + + E ++R + + + + K+
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 414
Query: 280 QEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQ 339
QEE + K E Q++++ + E H Q+KI+E E E + + I+ Q Q
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE-EKRQEEEKIREQEKRQ 473
Query: 340 E---KLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKV 396
E K+ +++ K+ + EEKI + + K+ + I E+++ +E+ +E + E K+
Sbjct: 474 EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQ-EEMWRQEEKI 532
Query: 397 KQQYQEEQQKRKL------LYQNVDELHRQVRTLQDKENLL---EMTCSQQQSRIQQQEA 447
++Q + +QK K+ + + +++ RQ + D+E + E +Q+ +I++QE
Sbjct: 533 REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEE 592
Query: 448 LLKQLENEKRKYDEHVKSNQE-LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHH 506
+++ E + R+ +E + +E + E+ K+ +++E ++E+ + ++ +R +K
Sbjct: 593 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEK-MRRQEEKIREQEKKIR 651
Query: 507 QQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKR 566
+Q+ K+++ + + + E ++ + ++ +Q + EK + ++++ Q L ++
Sbjct: 652 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
Query: 567 KLQE 570
K+QE
Sbjct: 712 KMQE 715
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/377 (17%), Positives = 165/377 (43%), Gaps = 44/377 (11%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
QE+ E + K RE+E+++ ++ + E EE + + E++ E
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRR-----QEEMMWEKEEKMRRQEEMMW----------EK 422
Query: 63 ESKDHFLIACDLLQRENS---ELETKVLKLSQEFAQLNHFT-LGGKTAPSNLITSENTCK 118
E K ++R+ E E K+ +L ++ + K I + +
Sbjct: 423 EEK---------MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 473
Query: 119 DPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRD 178
+ E+ E +I+ ++E+ E K+ +++K +E ++E R+ Q+E Q+ +
Sbjct: 474 EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE-KRQEQEEMWRQEEKI 532
Query: 179 MKDEE--KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYN 236
+ EE ++++ + EE +R +EE + + Q + EK++
Sbjct: 533 REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE--EKIR-E 589
Query: 237 QQGEVQQLHQNLHRLQILCNSAENEL------RYERGQNLDLKQHNSLLQEENIKIKIE- 289
Q+ ++++ + + + + E ++ E+ + + ++ QEE I+ + +
Sbjct: 590 QEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK 649
Query: 290 LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKV 349
++ ++K+ + +M + ++K+ E E ++ + + ++ Q +EK+ +++ ++
Sbjct: 650 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ---EEKMWEQEVRL 706
Query: 350 ADAEEKILDLQRKLEHA 366
EEK+ + Q LE A
Sbjct: 707 RQQEEKMQEHQEHLEAA 723
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 102 bits (253), Expect = 2e-21
Identities = 167/796 (20%), Positives = 341/796 (42%), Gaps = 102/796 (12%)
Query: 31 EKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENSELETKVLKLS 90
E+ + + EEL K + + + N + E E+ L+A L +E + ET++ +
Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLT----EMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 91 QEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQ 150
+E + + T K E E + ++++R EE EE C L K+
Sbjct: 900 EE------------------LRARLTAKKQELEE--ICHDLEARVEEEEERCQHLQAEKK 939
Query: 151 KEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHI--NQS 208
K +++++E + ++EE ++Q ++ E +L EE + L ++ + +
Sbjct: 940 KM--QQNIQE--LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK 995
Query: 209 LLQSQSSGDSSDDSGAQHPSSG-EKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERG 267
LL+ + + +++ + + S KLK + + L + L R + E R G
Sbjct: 996 LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
Query: 268 QNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLK 327
+ DL + LQ + ++K++L +++L + A+ +KI+ELE ++
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI-- 1113
Query: 328 HTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCIS--EKQQLEEK 385
+ LQE L E++ AE++ DL +LE A K L DT S +Q+L K
Sbjct: 1114 --------SELQEDLESERASRNKAEKQKRDLGEELE-ALKTELEDTLDSTAAQQELRSK 1164
Query: 386 -------IKEATQNEAKVKQ-QYQEEQQKRKLLYQNVDELHRQV-RTLQDKENL--LEMT 434
+K+ + EAK + Q QE +QK Q V+EL Q+ +T + K NL + T
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHS---QAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 435 CSQQQSRIQQQEALLKQLENEKRKYDEHVKSN-QELSEKLSKLQQEKEALREEYLRLLKL 493
++ + + +L Q + + + V++ QEL K + E E +R E +
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN----EGERVRTELADKVTK 1277
Query: 494 LNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQ 553
L V + N Q K K LT + + +Q +D +LQ + ++ ++ +
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSK----LTKDFSALE---SQLQDTQELLQEENRQKLSLSTK 1330
Query: 554 ITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKE-------------- 599
+ D EK +EQ+ E+E+ H+ + I+++ ++V M K+
Sbjct: 1331 LKQVED----EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 600 ----NKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQ 655
K L+ S R +++ +++ ++ R + L + V R +L +K+
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKT-KTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 656 KEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNEIL------P 709
+ E T + + D + EA EK + + + + +E + E L
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 710 LSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGY-INVASL 768
+ + S + +S L++++ ++ E+ + L +++++ +N+ ++
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 769 KE--THGIQEQDQKSE 782
K +Q +D++SE
Sbjct: 1566 KAQFERDLQGRDEQSE 1581
Score = 84.0 bits (206), Expect = 5e-16
Identities = 173/864 (20%), Positives = 338/864 (39%), Gaps = 141/864 (16%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSEL-ICLYNEVHNLP 59
M+ +K ES+ S+ +E + + + AEK + EEL+ K+EL L +
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 60 GESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKD 119
S+ + I L+ E E ++ ++ Q+ +Q A L K
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ----------AVEELAEQLEQTKR 1210
Query: 120 PESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDM 179
++N LE Q+ + E EL E+ +G + +K E Q +
Sbjct: 1211 VKAN---LEKAKQTLENERGELA--------NEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 180 KDEEKEQQLTMKPEEIVRLREELSHINQSLLQS------------------QSSGDSSDD 221
K E E+ T +++ +L+ EL ++ L QS Q + + +
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 222 SGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQH-----N 276
Q S KLK + E + L + ++ E ++ Q D+K+
Sbjct: 1320 ENRQKLSLSTKLK-QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Query: 277 SLLQEENIKIKI-----------ELKHAQQKLLDSTKM-----CSSLTAEYKHCQQKIKE 320
L E +K K+ E K A L+ TK L + H +Q
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 321 LELEVLKHTQSIKSQNNLQEKLVQEK----SKVADAEEKILDLQRKLEHAHKVCLTDTCI 376
LE + K Q + + + K +E+ ++ + E K L L R LE A +
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA---------M 1489
Query: 377 SEKQQLEE-------KIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQD--- 426
+K +LE ++++ ++ V + E ++ ++ L Q V+E+ Q+ L+D
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 427 --KENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKE--- 481
++ L + + Q + Q + L + E + K + V+ +E+ +L ++++
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 482 ALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTN-----------------EVE 524
A R++ LK L H+ + N+ + +L+K++ ++ + + +
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 525 LRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTL--------------LLEKRKLQE 570
+K++ E E+ LQ ++ + + Q + D L L EKR+L+
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 571 QVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGE 630
++ + E+ + + I R + K N Q+ + + L LER H ++ E
Sbjct: 1730 RIAQLEEELEEEQGNTELINDR---LKKANLQIDQINTDLN-----LER----SHAQKNE 1777
Query: 631 NLK-EFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHE-DESVPEATEKWKHS 688
N + + + KL + T K K S + A+L+ + D E K
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 689 EQMETTISDIL---ESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSP 745
+ E + D+L + E N + + L + L+E EE +++ A AS +
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE-EAQRANASRRKL 1896
Query: 746 EKSPENLVCSQNSEAGYINVASLK 769
++ E+ ++ ++A V+SLK
Sbjct: 1897 QRELED--ATETADAMNREVSSLK 1918
Score = 78.6 bits (192), Expect = 2e-14
Identities = 122/633 (19%), Positives = 267/633 (42%), Gaps = 85/633 (13%)
Query: 1 MSQEKN---EMFESEWSKEREREKQLAS-----------------GLDTAEKA---LKVE 37
+ EKN E E E + EKQ+A+ L+TAE+ L+ +
Sbjct: 1334 VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKD 1393
Query: 38 SEELQKSKSELICLYNEVHNLPGESESK-DHFLIACDLLQRENSELETKVLKLSQEFAQL 96
E L + E + Y+++ + + D L+ D ++ LE K K Q A+
Sbjct: 1394 LEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 97 NHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPE- 155
T+ K A +E ++ E+ L ++ E+ EL +L ++ + E+ +
Sbjct: 1454 K--TISAKYAEER-DRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDL 1509
Query: 156 ----ESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQ 211
+ V + E K QQ +MK + +E + ++ E +LR E++ LQ
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN------LQ 1563
Query: 212 SQSSGDSSDDSGAQHPSSGEKLKYNQQ-GEVQQLHQNLHRLQILCNSAENELRYERGQNL 270
+ + D G S +K + +Q E++ ++ + + + +A +L +
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE------M 1617
Query: 271 DLKQHNSLLQEENI----------KIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKE 320
DLK + + N K++ ++K ++L D+ + A+ K ++K+K
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 1677
Query: 321 LELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQ 380
+E E+++ + + + + + QE+ ++AD E A+ + EK+
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELAD------------EIANSSGKGALALEEKR 1725
Query: 381 QLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQS 440
+LE +I A+++++ +EEQ +L+ + + + Q+ + NL ++S
Sbjct: 1726 RLEARI-------AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL-------ERS 1771
Query: 441 RIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRN 500
Q+ E +QLE + ++ VK + SK + AL + +L + L+ +
Sbjct: 1772 HAQKNENARQQLERQNKEL--KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 501 YNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDT 560
Q + +K+K L +V+ + Q++D+ ++++ K ++ +
Sbjct: 1830 RQAACKQVRRTEKKLKDVLL-QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888
Query: 561 LLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRV 593
+RKLQ ++ + + + +SS+++++
Sbjct: 1889 ANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 33.9 bits (76), Expect = 0.60
Identities = 68/353 (19%), Positives = 152/353 (43%), Gaps = 35/353 (9%)
Query: 21 KQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENS 80
K L + +D+A K ++L+K ++++ E L S++ L +++
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE---LDDTRASREEILAQAKENEKKLK 1676
Query: 81 ELETKVLKLSQEFA---------QLNHFTLGGKTAPSN----LITSENTCKDPESNEPIL 127
+E ++++L +E A Q L + A S+ L E + E+ L
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK--RRLEARIAQL 1734
Query: 128 ETEIQSRKEETEELCPKLGERKQK--EIPEESVKEGSFPR--EGQKEEGSQQNRDMKDEE 183
E E++ + TE + +L + + +I + E S + E +++ +QN+++K +
Sbjct: 1735 EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKL 1794
Query: 184 KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGA--QHPSSGEKLKYNQQGEV 241
+E + T+K + + + I Q L+ Q ++ + A Q + +KLK + +V
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQ--LEEQLDNETKERQAACKQVRRTEKKLK-DVLLQV 1851
Query: 242 QQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDST 301
+N + + + A L+ LK+ +EE + + Q++L D+T
Sbjct: 1852 DDERRNAEQYKDQADKASTRLK-------QLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904
Query: 302 KMCSSLTAEYKHCQQKIKELELE-VLKHTQSIKSQNNLQEKLVQEKSKVADAE 353
+ ++ E + K++ +L V+ + K + ++ V K+ A+A+
Sbjct: 1905 ETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAK 1957
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 100 bits (249), Expect = 5e-21
Identities = 152/728 (20%), Positives = 316/728 (43%), Gaps = 87/728 (11%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
QE+ +++SE +E+ +QL + ++ L++ + + + ++L + L E
Sbjct: 406 QERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESEL 465
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPES 122
E+KD L L EN EL+ +V AQ L + S+ +
Sbjct: 466 ENKDEILRDKFSLMNENRELKVRVA------AQNERLDLCQQEIESSRV----------- 508
Query: 123 NEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDE 182
E++S ++ +L P E + + SF + + G + +
Sbjct: 509 -------ELRSLEKIISQL-PLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVIS 560
Query: 183 EKEQQLTMKPEEIVRLREEL--SHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGE 240
E +L +K EI +L L + ++QSL+ S +SS S + + KL +Q E
Sbjct: 561 ELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLE--TEPVKLGGHQVAE 618
Query: 241 VQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKH-------A 293
+ QN H + E E + +L+ ++ EN +K+ + H
Sbjct: 619 SVK-DQNQHTMN---KQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLI 674
Query: 294 QQKLLDSTKMCSSLTAEY-KHCQQKI---KELELEVLKHTQSIKSQNNLQEKLVQEKSKV 349
Q++LL+ S L +E K C Q + K+LE +++ ++ L+++L+++ K+
Sbjct: 675 QEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKI 734
Query: 350 ADAEEKILDLQRKLEHAHKVCLT-----DTCISEKQQLEEKIKEATQNEAKVKQQYQEEQ 404
E I EH K+CL + + +++E++I+ K QQ++E++
Sbjct: 735 RSLETNI-----NTEH-EKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
Query: 405 QKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVK 464
+ +L Q++ + +Q L+ + LL + + + +++ LK L+N
Sbjct: 789 KTMSMLQQDI--ICKQ-HHLESLDRLLTESKGEMKKENMKKDEALKALQN---------- 835
Query: 465 SNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVE 524
++SE+ K++Q AL L+ LN + EK +Q K + Y L E++
Sbjct: 836 ---QVSEETIKVRQLDSALEICKEELVLHLN-QLEGNKEKFEKQLKKKSEEVYCLQKELK 891
Query: 525 LRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKW 584
+++ + + ++ ILQH +++++ + Q T +N L + KL++QV + EQ + +
Sbjct: 892 IKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR- 950
Query: 585 TISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRG 644
S ++ M+++ + + Q++ L R + I + +E +
Sbjct: 951 --ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME----K 1004
Query: 645 KLASLPPTKKQKEIYSTE---VFTSNNAELQHEDESVPEATEKWKHSEQMETTIS----D 697
++ L + K ++ ++ + EL+ + +V E EK +HS + E T + +
Sbjct: 1005 EIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKE-LEKLQHSTETELTEALQKRE 1063
Query: 698 ILESEVVN 705
+LE+E+ N
Sbjct: 1064 VLETELQN 1071
Score = 92.0 bits (227), Expect = 2e-18
Identities = 164/826 (19%), Positives = 346/826 (41%), Gaps = 111/826 (13%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
+ + ++ KER+R L T + L+ + +++ S+L N H
Sbjct: 620 VKDQNQHTMNKQYEKERQR-------LVTGIEELRTKLIQIEAENSDL--KVNMAHR--- 667
Query: 61 ESESKDHFLIACDLLQR--ENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCK 118
+ LI +LL++ +S+LE+++ K + L L K + I ++N
Sbjct: 668 ---TSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK-QLEEKIVAYSSIAAKNAEL 723
Query: 119 DPE---SNEPI--LETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGS 173
+ E NE I LET I + E E++C L K K+I E KE ++ ++ E
Sbjct: 724 EQELMEKNEKIRSLETNINT---EHEKIC--LAFEKAKKIHLEQHKE--MEKQIERLEAQ 776
Query: 174 QQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSS----GDSSDDS--GAQHP 227
+ +D + +E+E+ ++M ++I+ + L +++ L +S+ D++ Q+
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
Query: 228 SSGEKLKYNQQGEVQQLHQN---LHRLQILCNSAENELRYERGQN------LDLKQHNSL 278
S E +K Q ++ + LH Q+ N + E + ++ +LK N
Sbjct: 837 VSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
Query: 279 LQE---ENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQ 335
LQE +N+ ++ L+ QQ L T L ++++ +LE E+ K +S +
Sbjct: 897 LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEK 956
Query: 336 -NNLQEK----------------------------LVQEKSKVADAEEKILDLQRKLEH- 365
++EK + Q K +++ E++I+ L+R E+
Sbjct: 957 LRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENK 1016
Query: 366 AHKVCLTDTCISE-KQQLEEK---IKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQV 421
A + D + + K +LE+K +KE + + + + E QKR++L + H ++
Sbjct: 1017 AMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGEL 1076
Query: 422 RTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVK-SNQELSEKLSKLQQEK 480
++ + L + Q ++++ +K L E R+ ++ QEL E L++
Sbjct: 1077 KSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERN 1136
Query: 481 EALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGIL 540
L++ ++ L++ +R + + Q+ +KL+ + E++ +K+I D++
Sbjct: 1137 WELKQRAAQVTH-LDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNA 1195
Query: 541 QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKE- 599
+ ++ +++ I Q + L E + Q+++ E E ++ + I++ + + +E
Sbjct: 1196 KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQEL 1255
Query: 600 ---NKQLQENSLRLT----QQIGF---LERIIRSIHIRRGENLKEFPVPKWWHRGKLASL 649
+Q+Q + L QQ+ +ER+ + E++K+ K H LA
Sbjct: 1256 RLTREQVQNSHTELAEARHQQVQAQREIERLSSEL-----EDMKQLSKEKDAHGNHLAEE 1310
Query: 650 PPTKKQKEIYSTEVFTSNNAELQHEDESVPEATE-----------KWKHSEQMETTISDI 698
K +E + + +L E ES+ EA KWK S + +
Sbjct: 1311 LGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQ 1370
Query: 699 LESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKS 744
L ++ L L + + L + E E ++ + ++
Sbjct: 1371 LNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGEN 1416
Score = 77.0 bits (188), Expect = 6e-14
Identities = 115/493 (23%), Positives = 205/493 (41%), Gaps = 79/493 (16%)
Query: 140 ELCPKL----------GERKQKEIPEESVKEGSFPREGQKE-EGSQQNRDMKDEEKEQQL 188
ELCP+L G Q + GS P + E E S + KD E+E L
Sbjct: 78 ELCPRLPRAGARERVRGFLTQTRVRSAQSPGGSLPSDDLGEMESSSSDYYNKDNEEESLL 137
Query: 189 TMKPEEIVRLREELSHIN---QSLLQSQSSGDSSDDSG-AQHPSSGEKLKYNQQGEVQQL 244
+ LR EL QSL + SS S++S A +PS EKL +VQ
Sbjct: 138 A----NVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLIL----DVQPS 189
Query: 245 HQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMC 304
H L + + EN + K+ + + + E+K ++KL +
Sbjct: 190 HPGL----LNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQN 245
Query: 305 SSLTAEYKHCQQKIKELELEVLKHTQSIKSQNN----------LQEKLVQEKSKVADAEE 354
+ L + K + + E+ + + + L+E+++ +++V+ ++
Sbjct: 246 ACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDK 305
Query: 355 KILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEA----KVKQQYQEEQQKRKLL 410
+ + + KLE + K+ I ++Q L+E +E + + + KQ + E+Q+ + L
Sbjct: 306 VLREAENKLEQSQKMV-----IEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEAL 360
Query: 411 YQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELS 470
Y N +EL + + + K +++ ++Q +E +L+ R K N+ L
Sbjct: 361 Y-NAEELSKAFQQYKKK-------VAEKLEKVQAEEEILE------RNLTNCEKENKRLQ 406
Query: 471 EKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRI 530
E+ + E E L+E+ LR LK N N EK VK +V +LT
Sbjct: 407 ERCGLYKSELEILKEK-LRQLKEEN---NNGKEKLRIMAVKNSEVMAQLT---------- 452
Query: 531 NQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQ 590
E IL K+E E +D+I +L+ E R+L+ +V Q + + + I S +
Sbjct: 453 ---ESRQSIL--KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
Query: 591 SRVLYMDKENKQL 603
+ ++K QL
Sbjct: 508 VELRSLEKIISQL 520
Score = 67.8 bits (164), Expect = 4e-11
Identities = 132/655 (20%), Positives = 278/655 (42%), Gaps = 80/655 (12%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
+++ R+K +S ++ +K E+L K + + CL + H+L + ES HF
Sbjct: 213 QKKPRDKMFSSSAPV-DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFES-IHF------ 264
Query: 75 LQRENSELETKVLKLSQEFA------QLNHFTLGGKTAPSNLITSENTCKDPESNEPILE 128
+ S + +L+ +Q+ A + L + + + + E K +S + ++E
Sbjct: 265 -ELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIE 323
Query: 129 TEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQL 188
E QS +E EE C KL K E K+G K Q+N + + E+ +
Sbjct: 324 KE-QSLQESKEE-CIKL-----KVDLLEQTKQG-------KRAERQRNEALYNAEELSKA 369
Query: 189 TMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNL 248
+ ++ V + E + +L+ + ++ Q K E++ L + L
Sbjct: 370 FQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYK------SELEILKEKL 423
Query: 249 HRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSS-- 306
+L+ N+ + +LR +N ++ + ++ +K++ EL++ + L D + +
Sbjct: 424 RQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483
Query: 307 -----LTAEYKH---CQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILD 358
+ A+ + CQQ+I+ +E L+ + I SQ L+ +L KS + ++ ++
Sbjct: 484 ELKVRVAAQNERLDLCQQEIESSRVE-LRSLEKIISQLPLKRELFGFKSYL--SKYQMSS 540
Query: 359 LQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELH 418
K + C + + + +++ IKEA K+ Q + L+ N +
Sbjct: 541 FSNKEDRCIGCCEANKLVISELRIKLAIKEA--EIQKLHANLTANQLSQSLITCNDSQES 598
Query: 419 RQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQ 478
++ +L+ + L + + Q Q + KQ E E+++ V +EL KL +++
Sbjct: 599 SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL---VTGIEELRTKLIQIEA 655
Query: 479 EKEAL------REEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRI-- 530
E L R +L++ + + + K + K K LT E +L +K +
Sbjct: 656 ENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTK--KCSQLLTLEKQLEEKIVAY 713
Query: 531 -------NQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNK 583
+ E E L K EK ++++ I +++ + L K ++ +EQ + +
Sbjct: 714 SSIAAKNAELEQE---LMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQ- 769
Query: 584 WTISSIQSRVLYMDKENKQLQENSLRLTQQI----GFLERIIRSIHIRRGENLKE 634
I +++++ D++ K+ ++ L Q I LE + R + +GE KE
Sbjct: 770 --IERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKE 822
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 100 bits (248), Expect = 7e-21
Identities = 165/732 (22%), Positives = 296/732 (40%), Gaps = 169/732 (23%)
Query: 2 SQEKNEMFESEWSKERE----REKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHN 57
+Q N+ E E K+++ R+K+ G + ++++SE L K ++EL + E+
Sbjct: 273 NQLMNDFAEKETLKQKQIDEIRDKKTGLG-----RIIELKSEILSKKQNELKNVKYELQQ 327
Query: 58 LPGESE---SKDHFLIACDL--------------------LQRENSELETKVLKLSQEFA 94
L G S+ D LI + LQ E ++L+ + KL QE
Sbjct: 328 LEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEME 387
Query: 95 QLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIP 154
QLNH T ++T + KD + + I+SR ++EL LG
Sbjct: 388 QLNHHTT--TRTQMEMLTKDKADKDEQIRK------IKSR--HSDELTSLLGY------- 430
Query: 155 EESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQS 214
FP + Q E+ L K +EI + R+ L+ +N+ L S+
Sbjct: 431 --------FPNKKQLEDW---------------LHSKSKEINQTRDRLAKLNKELASSEQ 467
Query: 215 SGDSSDDS---GAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLD 271
+ + ++ + SS E ++ G Q +L RL+ + + G
Sbjct: 468 NKNHINNELKRKEEQLSSYEDKLFDVCGS-QDFESDLDRLKEEIEKSSKQRAMLAGATAV 526
Query: 272 LKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEV------ 325
Q + L +EN + Q + ++ S L ++ + K+K E E+
Sbjct: 527 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKR 586
Query: 326 ----------------LKHTQSIKSQNNLQE--KLVQEKSKVADAEEKILDLQRKLEHAH 367
LK + + +N LQ + +Q + +E +L E +
Sbjct: 587 RDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 646
Query: 368 KVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDK 427
KVCLTD I E+ Q+E K E + K Q + + + + Q E ++ T+ K
Sbjct: 647 KVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK 706
Query: 428 ENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEK--------------- 472
L QQ +IQ ++ +L++EK + +++ Q+L E+
Sbjct: 707 IELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREI 766
Query: 473 -------------LSKLQQEKEAL----------REEYLRLL--KLLNVH-----VRNY- 501
L K QQEKE L ++ L + K+ N+H + NY
Sbjct: 767 KDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYI 826
Query: 502 ----NEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQ 557
++ Q++ +L KV +L +E E ++IN +++ +++ I+ +K IQ++
Sbjct: 827 QDGKDDYKKQKETELNKVIAQL-SECEKHKEKIN---EDMRLMRQDIDTQK-IQERWL-- 879
Query: 558 NDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQEN--------SLR 609
D L L KR + + +E+E+ H + Q +VL M E+++L+EN +L
Sbjct: 880 QDNLTLRKRNEELKEVEEERKQHLKEMG----QMQVLQMKSEHQKLEENIDNIKRNHNLA 935
Query: 610 LTQQIGFLERII 621
L +Q G+ E II
Sbjct: 936 LGRQKGYEEEII 947
Score = 60.5 bits (145), Expect = 6e-09
Identities = 151/710 (21%), Positives = 305/710 (42%), Gaps = 129/710 (18%)
Query: 2 SQEKNEMFESEWSKEREREKQLASGL------DTAEKALKVESEELQKSKSELICLYNEV 55
S+E + +E+E + R K++ L D KAL ++++K SEL +V
Sbjct: 98 SKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKV 157
Query: 56 ------------HNLPGESESKDHFLIACD-----------LLQRENSELETKVLKLS-Q 91
HN K+ L+ C LL +E SEL + +L Q
Sbjct: 158 FQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQ 217
Query: 92 EFAQLNHFTLGGKTAPSNLITSENTCKDPESNE--PILETEIQS------RKEETE---- 139
H A +LI S T + + E P E +I++ ++E E
Sbjct: 218 ADRHQEHI-----RARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTA 272
Query: 140 -ELCPKLGER---KQKEIPEESVKEGSFPR--EGQKEEGSQQNRDMKDEEKE-QQLTMKP 192
+L E+ KQK+I E K+ R E + E S++ ++K+ + E QQL
Sbjct: 273 NQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSS 332
Query: 193 EEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQ 252
+ I+ L +EL + L S++ +S+ ++ S + K + +++L Q + +L
Sbjct: 333 DRILELDQELIKAEREL--SKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL- 389
Query: 253 ILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQ-----------KLLDST 301
N R Q +++ + ++E I+ KI+ +H+ + K L+
Sbjct: 390 -------NHHTTTRTQ-MEMLTKDKADKDEQIR-KIKSRHSDELTSLLGYFPNKKQLED- 439
Query: 302 KMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQR 361
S + E + ++ +L E+ S +++N++ +L +++ +++ E+K+ D
Sbjct: 440 -WLHSKSKEINQTRDRLAKLNKEL---ASSEQNKNHINNELKRKEEQLSSYEDKLFD--- 492
Query: 362 KLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVK----------QQYQEEQQK----R 407
VC + S+ +L+E+I+++++ A + Q +E Q
Sbjct: 493 -------VCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVC 545
Query: 408 KLLYQNVDELHRQVRTLQDKENL----LEMTCSQQQSRIQQQEALLKQLENEKRKYDEHV 463
+ ++Q EL + LQ K L L+ T S+ + + ++++ +L + + D
Sbjct: 546 QRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKE 605
Query: 464 KSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEV 523
K EL KL + ++ + L+ + LL + + KV L V ++
Sbjct: 606 KEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIM----PEEESAKVCLTDVTIMERFQM 661
Query: 524 ELRD--KRINQFEDEI-GI-----LQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ 575
EL+D ++I Q ++ GI +Q ++++ Q ++ + + L ++ +Q+Q Q
Sbjct: 662 ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQ---Q 718
Query: 576 EQLIHSNKWTISSIQSRVLYMD---KENKQLQENSLRLTQQIGFLERIIR 622
EQ+ H K T + ++S L + + +QL+E ++ L+ ++ L R I+
Sbjct: 719 EQIQHL-KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIK 767
Score = 58.9 bits (141), Expect = 2e-08
Identities = 86/456 (18%), Positives = 212/456 (46%), Gaps = 83/456 (18%)
Query: 272 LKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELE---LEVLKH 328
LKQ+ +E+ +I+ ++ + +L S ++ S E + ++KE+E +++K
Sbjct: 74 LKQY----KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKL 129
Query: 329 TQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKE 388
IK+ ++ ++++ ++ S++ + EK+ Q +E++ +
Sbjct: 130 DNEIKALDSRKKQMEKDNSELEEKMEKVF----------------------QGTDEQLND 167
Query: 389 ATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTL-QDKENL------LEMTCSQQQSR 441
N ++ +E+++K ++ +++L+++ R L Q+K L L++ + Q
Sbjct: 168 LYHNH---QRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEH 224
Query: 442 IQQQEALLKQL--ENEKRKYDEHVKSNQELS--EKLSKLQQEKEALREEYLRLLKLLNVH 497
I+ +++L++ L + E ++ S +++ KL + +QE EA K N
Sbjct: 225 IRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEA---------KTANQL 275
Query: 498 VRNYNEKHHQQKVKLQKVKYRLT---NEVELRDKRINQFEDEIGILQHKIEKEKAIQDQI 554
+ ++ EK ++ ++ +++ + T +EL+ + +++ ++E+ +++++++ + D+I
Sbjct: 276 MNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRI 335
Query: 555 TAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSR-------VLYMDKENKQLQENS 607
+ L+ +R+L + E+ + + K + S+Q+ + +D+E +QL ++
Sbjct: 336 LELDQELIKAERELSK--AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHT 393
Query: 608 L------RLTQQIGFLERIIRSIHIRRGENLKE----FPVPKW---WHRGKLASLPPT-- 652
LT+ + IR I R + L FP K W K + T
Sbjct: 394 TTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRD 453
Query: 653 ---KKQKEIYSTEVFTSN-NAELQHEDESVPEATEK 684
K KE+ S+E ++ N EL+ ++E + +K
Sbjct: 454 RLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDK 489
Score = 46.2 bits (108), Expect = 1e-04
Identities = 53/208 (25%), Positives = 96/208 (46%), Gaps = 27/208 (12%)
Query: 408 KLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ 467
K L Q DE+ R ++ E L ++ +Q Q ++++ + LK L+ K K E
Sbjct: 31 KALKQKFDEIFSATRYIKALETLRQVRQTQGQ-KVKEYQMELKYLKQYKEKACE---IRD 86
Query: 468 ELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRD 527
+++ K ++L KE ++ L L N R +H+ K+ +L NE++ D
Sbjct: 87 QITSKEAQLTSSKEIVKSYENELDPLKN---RLKEIEHNLSKIM------KLDNEIKALD 137
Query: 528 KRINQFEDEIGILQHKIEK-----EKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSN 582
R Q E + L+ K+EK ++ + D T+ ++RKL + E E+L N
Sbjct: 138 SRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKL---N 194
Query: 583 KWTISSIQSRVLYMDKENKQLQENSLRL 610
K +SR+L +K +++ L+L
Sbjct: 195 K------ESRLLNQEKSELLVEQGRLQL 216
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 100 bits (248), Expect = 7e-21
Identities = 165/732 (22%), Positives = 296/732 (40%), Gaps = 169/732 (23%)
Query: 2 SQEKNEMFESEWSKERE----REKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHN 57
+Q N+ E E K+++ R+K+ G + ++++SE L K ++EL + E+
Sbjct: 412 NQLMNDFAEKETLKQKQIDEIRDKKTGLG-----RIIELKSEILSKKQNELKNVKYELQQ 466
Query: 58 LPGESE---SKDHFLIACDL--------------------LQRENSELETKVLKLSQEFA 94
L G S+ D LI + LQ E ++L+ + KL QE
Sbjct: 467 LEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEME 526
Query: 95 QLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIP 154
QLNH T ++T + KD + + I+SR ++EL LG
Sbjct: 527 QLNHHTT--TRTQMEMLTKDKADKDEQIRK------IKSR--HSDELTSLLGY------- 569
Query: 155 EESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQS 214
FP + Q E+ L K +EI + R+ L+ +N+ L S+
Sbjct: 570 --------FPNKKQLEDW---------------LHSKSKEINQTRDRLAKLNKELASSEQ 606
Query: 215 SGDSSDDS---GAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLD 271
+ + ++ + SS E ++ G Q +L RL+ + + G
Sbjct: 607 NKNHINNELKRKEEQLSSYEDKLFDVCGS-QDFESDLDRLKEEIEKSSKQRAMLAGATAV 665
Query: 272 LKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEV------ 325
Q + L +EN + Q + ++ S L ++ + K+K E E+
Sbjct: 666 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKR 725
Query: 326 ----------------LKHTQSIKSQNNLQE--KLVQEKSKVADAEEKILDLQRKLEHAH 367
LK + + +N LQ + +Q + +E +L E +
Sbjct: 726 RDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 785
Query: 368 KVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDK 427
KVCLTD I E+ Q+E K E + K Q + + + + Q E ++ T+ K
Sbjct: 786 KVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK 845
Query: 428 ENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEK--------------- 472
L QQ +IQ ++ +L++EK + +++ Q+L E+
Sbjct: 846 IELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREI 905
Query: 473 -------------LSKLQQEKEAL----------REEYLRLL--KLLNVH-----VRNY- 501
L K QQEKE L ++ L + K+ N+H + NY
Sbjct: 906 KDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYI 965
Query: 502 ----NEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQ 557
++ Q++ +L KV +L +E E ++IN +++ +++ I+ +K IQ++
Sbjct: 966 QDGKDDYKKQKETELNKVIAQL-SECEKHKEKIN---EDMRLMRQDIDTQK-IQERWL-- 1018
Query: 558 NDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQEN--------SLR 609
D L L KR + + +E+E+ H + Q +VL M E+++L+EN +L
Sbjct: 1019 QDNLTLRKRNEELKEVEEERKQHLKEMG----QMQVLQMKSEHQKLEENIDNIKRNHNLA 1074
Query: 610 LTQQIGFLERII 621
L +Q G+ E II
Sbjct: 1075 LGRQKGYEEEII 1086
Score = 60.5 bits (145), Expect = 6e-09
Identities = 151/710 (21%), Positives = 305/710 (42%), Gaps = 129/710 (18%)
Query: 2 SQEKNEMFESEWSKEREREKQLASGL------DTAEKALKVESEELQKSKSELICLYNEV 55
S+E + +E+E + R K++ L D KAL ++++K SEL +V
Sbjct: 237 SKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKV 296
Query: 56 ------------HNLPGESESKDHFLIACD-----------LLQRENSELETKVLKLS-Q 91
HN K+ L+ C LL +E SEL + +L Q
Sbjct: 297 FQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQ 356
Query: 92 EFAQLNHFTLGGKTAPSNLITSENTCKDPESNE--PILETEIQS------RKEETE---- 139
H A +LI S T + + E P E +I++ ++E E
Sbjct: 357 ADRHQEHI-----RARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTA 411
Query: 140 -ELCPKLGER---KQKEIPEESVKEGSFPR--EGQKEEGSQQNRDMKDEEKE-QQLTMKP 192
+L E+ KQK+I E K+ R E + E S++ ++K+ + E QQL
Sbjct: 412 NQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSS 471
Query: 193 EEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQ 252
+ I+ L +EL + L S++ +S+ ++ S + K + +++L Q + +L
Sbjct: 472 DRILELDQELIKAEREL--SKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL- 528
Query: 253 ILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQ-----------KLLDST 301
N R Q +++ + ++E I+ KI+ +H+ + K L+
Sbjct: 529 -------NHHTTTRTQ-MEMLTKDKADKDEQIR-KIKSRHSDELTSLLGYFPNKKQLED- 578
Query: 302 KMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQR 361
S + E + ++ +L E+ S +++N++ +L +++ +++ E+K+ D
Sbjct: 579 -WLHSKSKEINQTRDRLAKLNKEL---ASSEQNKNHINNELKRKEEQLSSYEDKLFD--- 631
Query: 362 KLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVK----------QQYQEEQQK----R 407
VC + S+ +L+E+I+++++ A + Q +E Q
Sbjct: 632 -------VCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVC 684
Query: 408 KLLYQNVDELHRQVRTLQDKENL----LEMTCSQQQSRIQQQEALLKQLENEKRKYDEHV 463
+ ++Q EL + LQ K L L+ T S+ + + ++++ +L + + D
Sbjct: 685 QRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKE 744
Query: 464 KSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEV 523
K EL KL + ++ + L+ + LL + + KV L V ++
Sbjct: 745 KEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIM----PEEESAKVCLTDVTIMERFQM 800
Query: 524 ELRD--KRINQFEDEI-GI-----LQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ 575
EL+D ++I Q ++ GI +Q ++++ Q ++ + + L ++ +Q+Q Q
Sbjct: 801 ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQ---Q 857
Query: 576 EQLIHSNKWTISSIQSRVLYMD---KENKQLQENSLRLTQQIGFLERIIR 622
EQ+ H K T + ++S L + + +QL+E ++ L+ ++ L R I+
Sbjct: 858 EQIQHL-KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIK 906
Score = 58.9 bits (141), Expect = 2e-08
Identities = 86/456 (18%), Positives = 212/456 (46%), Gaps = 83/456 (18%)
Query: 272 LKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELE---LEVLKH 328
LKQ+ +E+ +I+ ++ + +L S ++ S E + ++KE+E +++K
Sbjct: 213 LKQY----KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKL 268
Query: 329 TQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKE 388
IK+ ++ ++++ ++ S++ + EK+ Q +E++ +
Sbjct: 269 DNEIKALDSRKKQMEKDNSELEEKMEKVF----------------------QGTDEQLND 306
Query: 389 ATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTL-QDKENL------LEMTCSQQQSR 441
N ++ +E+++K ++ +++L+++ R L Q+K L L++ + Q
Sbjct: 307 LYHNH---QRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEH 363
Query: 442 IQQQEALLKQL--ENEKRKYDEHVKSNQELS--EKLSKLQQEKEALREEYLRLLKLLNVH 497
I+ +++L++ L + E ++ S +++ KL + +QE EA K N
Sbjct: 364 IRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEA---------KTANQL 414
Query: 498 VRNYNEKHHQQKVKLQKVKYRLT---NEVELRDKRINQFEDEIGILQHKIEKEKAIQDQI 554
+ ++ EK ++ ++ +++ + T +EL+ + +++ ++E+ +++++++ + D+I
Sbjct: 415 MNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRI 474
Query: 555 TAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSR-------VLYMDKENKQLQENS 607
+ L+ +R+L + E+ + + K + S+Q+ + +D+E +QL ++
Sbjct: 475 LELDQELIKAERELSK--AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHT 532
Query: 608 L------RLTQQIGFLERIIRSIHIRRGENLKE----FPVPKW---WHRGKLASLPPT-- 652
LT+ + IR I R + L FP K W K + T
Sbjct: 533 TTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRD 592
Query: 653 ---KKQKEIYSTEVFTSN-NAELQHEDESVPEATEK 684
K KE+ S+E ++ N EL+ ++E + +K
Sbjct: 593 RLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDK 628
Score = 50.1 bits (118), Expect = 8e-06
Identities = 61/258 (23%), Positives = 115/258 (44%), Gaps = 31/258 (12%)
Query: 362 KLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQ----KRKLLYQNVDEL 417
+ +H KV L+ C +++ + + V +QE+ + K L Q DE+
Sbjct: 120 RTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEI 179
Query: 418 HRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQ 477
R ++ E L ++ +Q Q ++++ + LK L+ K K E +++ K ++L
Sbjct: 180 FSATRYIKALETLRQVRQTQGQ-KVKEYQMELKYLKQYKEKACE---IRDQITSKEAQLT 235
Query: 478 QEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEI 537
KE ++ L L N R +H+ K+ +L NE++ D R Q E +
Sbjct: 236 SSKEIVKSYENELDPLKN---RLKEIEHNLSKIM------KLDNEIKALDSRKKQMEKDN 286
Query: 538 GILQHKIEK-----EKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSR 592
L+ K+EK ++ + D T+ ++RKL + E E+L NK +SR
Sbjct: 287 SELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKL---NK------ESR 337
Query: 593 VLYMDKENKQLQENSLRL 610
+L +K +++ L+L
Sbjct: 338 LLNQEKSELLVEQGRLQL 355
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 99.8 bits (247), Expect = 9e-21
Identities = 170/778 (21%), Positives = 326/778 (41%), Gaps = 105/778 (13%)
Query: 10 ESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFL 69
E E K ++ K+L S ++E + EL K E+ E+ L
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE----- 299
Query: 70 IACDLLQRENSELETKVLKLSQEFAQL----NHFTLGGKTAPSNLITSENTCKDPESNEP 125
L ++N L +LK Q++ +L N ++ K + L + C+ +S
Sbjct: 300 -----LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS 354
Query: 126 ILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKE 185
ET + E E GE QK E S E + + + QQ R EEKE
Sbjct: 355 ASETSLHRIHVELSEK----GEATQKLKEELSEVETKYQHLKAEFKQLQQQR----EEKE 406
Query: 186 QQLTMKPEEIVRLREELSHINQSLLQSQSS-GDSSDDSGAQHPSSGEKLKYNQQGEVQQL 244
Q ++L+ E++ ++ LL+++ G++ Q S EKL +Q +V L
Sbjct: 407 QHG-------LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ-QVADL 458
Query: 245 HQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMC 304
L RL+ + L K NS + + K + +H +Q+ L
Sbjct: 459 QLKLSRLE---------------EQLKEKVTNSTELQHQLD-KTKQQHQEQQALQQ---- 498
Query: 305 SSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLE 364
S TA+ + Q ++++ ++ Q I+ NL+ L + K ++ E++ DL K++
Sbjct: 499 -STTAKLREAQNDLEQVLRQIGDKDQKIQ---NLEALLQKSKENISLLEKEREDLYAKIQ 554
Query: 365 HAHKVCLTDTCISEKQQ-LEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRT 423
+ EK L+E++ + T+ K+K Q + +Q ++ L+ V E +R
Sbjct: 555 AGEGETAVLNQLQEKNHTLQEQVTQLTE---KLKNQSESHKQAQENLHDQVQEQKAHLRA 611
Query: 424 LQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ-----ELSEKLSKLQQ 478
QD+ LE + ++ S++ + + + QL+ + + E + S + + ++ + L
Sbjct: 612 AQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671
Query: 479 EKEALREEYLRLLKLL----NVHVRNYNEKHH----QQKVKLQKVKY----RLTNEVELR 526
+ AL+++ L K+ V + +++ H + +K K KY + T E+E +
Sbjct: 672 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731
Query: 527 DKRINQFEDEIGILQHKIEKEKAIQD--QITAQNDTLLLEKRKLQEQVIEQEQLIHSNKW 584
K++ E L+ K KE+A+QD Q N L L +L +Q+ +++++ S +
Sbjct: 732 IKKL-----EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 585 TISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRG 644
+ +S L K+ QE ++ +Q E + + I+ E +
Sbjct: 787 DLQK-KSEALESIKQKLTKQEEEKQILKQ--DFETLSQETKIQHEELNNRI-------QT 836
Query: 645 KLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILES--E 702
+ L K +KE TE+ T + + D +E K +++ + I D+ ++ E
Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
Query: 703 VVNEI-LPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKS-PENLVCSQNS 758
+ +++ + + N+ K L +S K KEA K S E L+ +QN+
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLE--------KEKEASHQLKLELNSMQEQLIQAQNT 946
Score = 91.7 bits (226), Expect = 2e-18
Identities = 183/923 (19%), Positives = 377/923 (40%), Gaps = 183/923 (19%)
Query: 11 SEWSKEREREKQLASGLDTAEKALKVESEELQKSKSE-------LICLYNEVHNLPGESE 63
SE + ++ K+ S ++T + LK E ++LQ+ + E L N++H+ E+E
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 64 S---------KDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSE 114
K+ ++ + L + ++ LKLS+ QL L ++
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487
Query: 115 NTCKDPESNEPILETEIQSRKEETEELCPKLGERKQK----EIPEESVKEGSFPREGQKE 170
++ ++ + +++ + + E++ ++G++ QK E + KE E ++E
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 171 E------GSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGA 224
+ + + ++ +E+ T++ E++ +L E+L + ++S Q+Q +
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQ-EQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
Query: 225 QHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYER-----------GQNLDLK 273
H + + + + V +L+ L+ + + + +++ + Q DL+
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ 666
Query: 274 QH-----NSLL--QEENIKIKIELKHAQQKLLDSTKMCSSLTA---EYKH----CQQKIK 319
H N+L Q+E KI +L KL D + CS L + EYK +QK +
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
Query: 320 ELELEVLK--------------HTQSIKSQNNLQEKL----------------------- 342
ELE ++ K Q ++ Q L L
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 343 -VQEKSKVADA---------EEK--------ILDLQRKLEHAHKVCLTDTCISEKQQ--- 381
+Q+KS+ ++ EEK L + K++H T ++E Q+
Sbjct: 787 DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846
Query: 382 -----------LEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENL 430
+++K+ + + + K ++++E QK K +++ +T ++ ++
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLE------KTCKELKHQ 900
Query: 431 LEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRL 490
L++ Q ++ +++Q+ L K LE EK + + E+L + Q + +E +L
Sbjct: 901 LQV---QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 491 LKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQF----------EDEIGIL 540
+N ++ +K Q + ++K + + EL +K Q +++I +L
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 541 QHKIEKE----KAIQDQITAQNDTLLLEKRKL----QEQVIEQEQLIHSNKWTISSIQSR 592
Q+ EK K +Q + LL ++ L ++ + QE LI SN+ I +
Sbjct: 1018 QNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLI-SNRNQIGNQNKL 1076
Query: 593 VLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPT 652
+ + L+++S + QQ+ ER I++ ++LKE + + KLA +
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQL--QERCKALQDIQKEKSLKEKELVN--EKSKLAEIEEI 1132
Query: 653 KKQKEIYSTEVFTSNNAELQ-HEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLS 711
K ++E + T N EL+ H+ ES+ E T K ++Q+ ++ + L L
Sbjct: 1133 KCRQE----KEITKLNEELKSHKLESIKEIT-NLKDAKQL-----------LIQQKLELQ 1176
Query: 712 NSSFSGKGLVESFASLQ---------ETEEIK----SKEAMASSKSPEKSPENLVCSQNS 758
+ S K VE Q E EE+K KEA S+ EK +N
Sbjct: 1177 GKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENE 1236
Query: 759 EAGYINVASLKETHGIQEQDQKS 781
+ + +L E G +++ +S
Sbjct: 1237 AKLTMQITALNENLGTVKKEWQS 1259
Score = 77.0 bits (188), Expect = 6e-14
Identities = 134/542 (24%), Positives = 226/542 (41%), Gaps = 96/542 (17%)
Query: 11 SEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLI 70
+E K + ++ L + L T + L S+ L+ SKSE E N G++ D
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF-----EKENQKGKAAILDLEKT 893
Query: 71 ACDL-----LQRENSELETKVLK--LSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESN 123
+L +Q EN+ E K LK L +E + L + LI ++NT K E
Sbjct: 894 CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 124 EPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEE 183
E L+ I K+ +E+ ++KQ E + +K QK E + +
Sbjct: 954 EQQLQGNINELKQSSEQ------KKKQIEALQGELKIAVL----QKTE--------LENK 995
Query: 184 KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDS--SDDSGAQHP---------SSGEK 232
+QQLT +E+ +E++S + + +SQ + SD G + S EK
Sbjct: 996 LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
Query: 233 LKY---------NQQGEVQQLHQNLHRLQILC--NSAENELRY-ERGQNL-DLKQHNSLL 279
L NQ G +L Q L + +SA+ E + ER + L D+++ SL
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
Query: 280 QEENIKIKIELKHAQQKLLDSTKMCSSLTAEYK-HCQQKIKELELEVLKHTQSIKSQNNL 338
++E + K +L ++ K + L E K H + IKE+ LK + + Q L
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN--LKDAKQLLIQQKL 1173
Query: 339 QEKLVQEKSKVADAEEK----ILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEA----- 389
+ + + K A +EK IL Q K E L I ++ +L +IKE
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE---LKKEFIEKEAKLHSEIKEKEVGMK 1230
Query: 390 --TQNEAK--------------VKQQYQEEQQKRKLLYQNVDELHRQVRTL-------QD 426
+NEAK VK+++Q Q++ L + D+L ++ L QD
Sbjct: 1231 KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
Query: 427 KENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQ-QEKEALRE 485
+ L C + + I++ + + +L+ RK D + QEL + LQ + +AL
Sbjct: 1291 ERRALLERCLKGEGEIEKLQTKVLELQ---RKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Query: 486 EY 487
++
Sbjct: 1348 KW 1349
Score = 63.5 bits (153), Expect = 7e-10
Identities = 116/532 (21%), Positives = 215/532 (40%), Gaps = 104/532 (19%)
Query: 307 LTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHA 366
L E + Q +KE + + + ++ LQ++ + V D+ ++ L+++LE A
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 367 HKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNV----DELHR--- 419
K E+K + A +K +Y EE+ R+ Q V +EL++
Sbjct: 148 QTE--NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEAT 205
Query: 420 --------------------------QVRTLQDKENL--------LEMTCSQQQSRIQQQ 445
QV+TL D L L+ C + QS+
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265
Query: 446 EALLKQLENEKRKYDE----HVKSNQELSEKLSKLQQEKEALRE-------EYLRLLKLL 494
EA + QL +E K + +V+ Q+L +++L Q+ + L E +Y +L +
Sbjct: 266 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
Query: 495 N---VHVRNYNEKHHQQKVKLQKVKYRLT-NEVELRDKRINQFEDEIGILQHKIEKEKAI 550
N V +N HQ+ + Q+++ RL+ +E L RI+ E G K+++E +
Sbjct: 326 NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH--RIHVELSEKGEATQKLKEELS- 382
Query: 551 QDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRL 610
++ + L E ++LQ+Q E+EQ L + E QL L
Sbjct: 383 --EVETKYQHLKAEFKQLQQQREEKEQ--------------HGLQLQSEINQLHSKLLET 426
Query: 611 TQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAE 670
+Q+G ++ E L + + KL+ L K+K +N+ E
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK--------VTNSTE 478
Query: 671 LQHEDESVPEATEKWKHSEQ---METTISDILESEVVNEILPLSNSSFSGKGLVESFASL 727
LQH+ + K +H EQ ++T + + E++ N++ + +++ +L
Sbjct: 479 LQHQLDKT-----KQQHQEQQALQQSTTAKLREAQ--NDLEQVLRQIGDKDQKIQNLEAL 531
Query: 728 QETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVAS--LKETHGIQEQ 777
+ KSKE ++ EK E+L + G V + ++ H +QEQ
Sbjct: 532 LQ----KSKENISLL---EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 99.0 bits (245), Expect = 2e-20
Identities = 118/606 (19%), Positives = 279/606 (46%), Gaps = 86/606 (14%)
Query: 147 ERKQKEI-----PEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREE 201
+ K+K+I PE + EG E +K+ Q ++ E + Q T++ L +
Sbjct: 46 DTKKKKINNGTNPETTTSEGCHSPEDEKKASHQHQEALRREIEAQDHTIR-----ILTCQ 100
Query: 202 LSHINQSLLQSQSS---------GDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQ 252
+ + +L SQ + G+S D +G H S ++ GE+Q+ +
Sbjct: 101 KTELETALYYSQDAARKFEDGNLGESKDLAGRLHHS------WHFAGELQRALSAVSTWH 154
Query: 253 ILCNSAENELRYERG-----------QNLDLKQHNSLLQE-------ENIKIKIELKHAQ 294
+ EL ER N +LK+ N+ LQE E +I++ +K +
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214
Query: 295 QKL-----LDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKV 349
+KL L ++L E +++++E E ++ K + + Q +E+L +++ K+
Sbjct: 215 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ---EERLREQEGKM 271
Query: 350 ADAEEKILDLQRKL-EHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRK 408
+ EEK+ +++L E ++ + + E+++L E+ ++ + E K+ +Q ++ +++ +
Sbjct: 272 REQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEE 331
Query: 409 LLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKR------KYDEH 462
+++ + L Q + ++++E + Q+ R+ +Q+ L++ E R + +E
Sbjct: 332 KMWRQEERLWEQEKQMREQEQKMR----DQEERMWEQDERLREKEERMREQEKMWEQEEK 387
Query: 463 VKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNE 522
++ + + E+ K+++E+E +RE+ ++ K ++ QQ++ QK K +
Sbjct: 388 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 447
Query: 523 VELRDKRINQFEDEIGILQHKIEKEKAI--QDQITAQNDTLLLEKRKLQEQVIEQEQLIH 580
++ ++++I + E++I + +EK + Q+++ Q D + ++ K+++Q EQ+
Sbjct: 448 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ--EQKMWDQ 505
Query: 581 SNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKW 640
+ M +++++L+E R+ +Q +++ + R E + K
Sbjct: 506 EER------------MWEQDERLREKEERMREQ----KKMWQQEEKMREEKKTQEQEKKT 549
Query: 641 WHRGKLASLPPTKKQKE---IYSTEVFTSNNAELQHEDESVPEATEK-WKHSEQMETTIS 696
W + + +++E E+ ++Q ++E + E EK W+ E+M+
Sbjct: 550 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 609
Query: 697 DILESE 702
+ E E
Sbjct: 610 KMWEQE 615
Score = 94.7 bits (234), Expect = 3e-19
Identities = 118/574 (20%), Positives = 258/574 (44%), Gaps = 67/574 (11%)
Query: 173 SQQNRDMKDEEKEQQLT-MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGE 231
S++ R K E +++ T + I + + + + + ++ +++ G P +
Sbjct: 14 SEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSEGCHSPEDEK 73
Query: 232 KLKYNQQGEVQ-QLHQNLHRLQIL-CNSAENELRYERGQNLDLKQHNSLLQEENIKIKIE 289
K + Q ++ ++ H ++IL C E E Q+ K + L E +
Sbjct: 74 KASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESK-DLAGR 132
Query: 290 LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKEL-------ELEVLKHT---QSIKSQN-NL 338
L H+ + + S+++ +K + I+EL LE+ ++T + +K +N L
Sbjct: 133 LHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAEL 192
Query: 339 QEKLVQEKSKVADAEEKILDLQRKLEHAHKV---CLTDTCISEKQQLEEKIKE------- 388
QEKL +S+ ++ + + +L+RKLE A + T+T E + EE+++E
Sbjct: 193 QEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRK 252
Query: 389 -----------ATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQ 437
+ E K+++Q ++ +++ K L + EL Q + L++++ L E
Sbjct: 253 QEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLRE----- 307
Query: 438 QQSRIQQQEALLKQLENEKRKYDEHV-KSNQELSEKLSKLQQEKEALREEYLRLLKLLNV 496
Q+ ++Q+QE + + E + R+ +E + + + L E+ +++++++ +R++ R+ + +
Sbjct: 308 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE-QDE 366
Query: 497 HVRNYNEK-HHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEK--------- 546
+R E+ Q+K+ Q+ K + + R+K++ + E+ + + K++K
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 426
Query: 547 EKAIQDQITAQNDTLLLEKRKLQEQ---VIEQEQLIHSNK--WTISSIQSRVLYMDKENK 601
EK Q Q + L E+ K+QEQ + EQE+ I + W R M ++
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Query: 602 QLQENSLRLTQQIGFL----ERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKE 657
Q+ E ++ Q + ER+ R + + K W + + +++K+
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEE-----KMREEKK 541
Query: 658 IYSTEVFTSNNAELQHEDESVPEATEKWKHSEQM 691
E T + E E+E + E +K + E+M
Sbjct: 542 TQEQEKKTWDQEEKMREEERMREREKKMREEEEM 575
Score = 89.0 bits (219), Expect = 2e-17
Identities = 100/549 (18%), Positives = 260/549 (47%), Gaps = 49/549 (8%)
Query: 75 LQRENSELETKVLKLSQEFA--QLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQ 132
L+++N+EL+ K+ E + QLN L K + + P+ L+ E+
Sbjct: 185 LKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL-------PQVQTNTLQEEMW 237
Query: 133 SRKEETEELCPKLGERKQKEI-PEESVKEGSFPREGQKEEGSQQNRDMKDEEKE---QQL 188
++EE E K+ ++++K EE ++E Q+E+ +Q + ++++EKE Q+
Sbjct: 238 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEK 297
Query: 189 TMKPEEIVRLREELSHINQSLL--QSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQ 246
++ ++ +R +EE + + Q + + + Q E+ K ++ E Q++
Sbjct: 298 ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE-QKMRD 356
Query: 247 NLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSS 306
R+ E + R + +Q QEE ++ + ++ ++K+ + +
Sbjct: 357 QEERMW------EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMRE 410
Query: 307 LTAEYKHCQQKIKELELEVLKHTQSIKSQNNL--QEKLVQEKSKVADAEEKILDLQRKLE 364
+ + ++ + E E + + + + + L QEK+ +++ K+ + EEKI D +
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 365 HAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTL 424
K+ ++++ E+ + + E K++ Q Q+ + + +++ + L + +
Sbjct: 471 QEKKMW-------RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERM 523
Query: 425 QDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQE--LSEKLSKLQQEKEA 482
++++ + QQ+ ++++++ K E EK+ +D+ K +E + E+ K+++E+E
Sbjct: 524 REQKKMW-----QQEEKMREEK---KTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 575
Query: 483 LREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVE--LRDKRINQFEDEIGIL 540
+RE+ ++ + +R EK +Q+ K+Q+ + ++ + E + ++ +++ ++
Sbjct: 576 MREQEEKMQE-QEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMM 634
Query: 541 QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKEN 600
+ EK + ++++ Q + + R+ +E++ EQE+ + + + Q + +E
Sbjct: 635 WEQEEKMQEQEEKMWEQEEKM----REQEEKMREQEEKMQGQEEKMRE-QEEKMQGQEEK 689
Query: 601 KQLQENSLR 609
+ QE +R
Sbjct: 690 MREQEEKMR 698
Score = 86.3 bits (212), Expect = 1e-16
Identities = 111/585 (18%), Positives = 261/585 (44%), Gaps = 76/585 (12%)
Query: 4 EKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESE 63
+ N + E W +E E +Q EK ++ + E++ + + L E E E
Sbjct: 228 QTNTLQEEMWRQEEELREQ--------EKKIRKQEEKMWRQEERL----REQEGKMREQE 275
Query: 64 SKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESN 123
K ++R+ L + +L ++ +L L E ++ E
Sbjct: 276 EK---------MRRQEKRLREQEKELREQEKELRE--------QKKLREQEEQMQEQEEK 318
Query: 124 EPILETEIQSRKEETEELCPKLGER-KQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDE 182
E +++ ++E+ +L E+ KQ E+ +++ Q E ++ M+++
Sbjct: 319 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 378
Query: 183 EK--EQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGA--QHPSSGEKLKYNQQ 238
EK EQ+ M+ EE +R RE+ + ++ Q + Q ++ + +Q
Sbjct: 379 EKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 438
Query: 239 GEVQQLHQNLHRLQILCNSAENELRYER---GQNLDLKQHNSLLQEENIKIKIE--LKHA 293
E + + + E ++R + GQ + + + ++E+ + E ++
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Query: 294 QQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAE 353
+QK+ D + + +++++E + ++ + + ++ + QE QEK K D E
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMRE-QKKMWQQEEKMREEKKTQE---QEK-KTWDQE 553
Query: 354 EKILDLQRKLEHAHKVCLTDTCISEKQQ-LEEKIKEATQNEAKVKQQYQEEQQKRKLLYQ 412
EK+ + +R E K+ + + E+++ ++E+ ++ + E K+ +Q ++ Q++ + +++
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 413 NVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEK 472
+++ Q +DK E +Q+ ++Q+QE + + E + R+ +E ++ +E
Sbjct: 614 QEEKMWEQEE--EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEE---- 667
Query: 473 LSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQ 532
K+Q ++E +RE+ ++ + EK +Q+ K++ + ++ + E K Q
Sbjct: 668 --KMQGQEEKMREQEEKM--------QGQEEKMREQEEKMRGQEEKMWGQEE---KMWGQ 714
Query: 533 FEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQ 577
E+++ + EKE+ I+DQ K K+QE++ E E+
Sbjct: 715 -EEKMWGQEEMREKEERIRDQ-----------KEKMQERLPEHEE 747
Score = 76.6 bits (187), Expect = 8e-14
Identities = 88/508 (17%), Positives = 226/508 (44%), Gaps = 25/508 (4%)
Query: 5 KNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESES 64
+ E + K RE+E+++ EK L+ + +EL++ + EL E
Sbjct: 260 QEERLREQEGKMREQEEKMRR----QEKRLREQEKELREQEKELREQKKLREQEEQMQEQ 315
Query: 65 KDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNE 124
++ + ++ + ++ + +L ++ Q+ + + + ++ E E
Sbjct: 316 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE--E 373
Query: 125 PILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEK 184
+ E E +EE + ++ ER++K EE RE +++ Q+ + EEK
Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETM-----REQEEKMQKQEENMWEQEEK 428
Query: 185 EQQLTMKPEEIVRL--REELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
E Q PE+ +L +E++ + + + + ++ Q + K +Q +
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488
Query: 243 QLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTK 302
+ R Q + E +E+ + L K+ ++E+ + E K ++K +
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEER--MREQKKMWQQEEKMREEKKTQEQE 546
Query: 303 MCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRK 362
+ E +++++E E ++ + + ++ Q +EK+ +++ K+ + EEK+ + + K
Sbjct: 547 KKTWDQEEKMREEERMREREKKMREEEEMMREQ---EEKMQEQEEKMREQEEKMWEQEEK 603
Query: 363 LEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVR 422
++ + +Q+ E+K++E + + +++ QE+++K + + E ++R
Sbjct: 604 MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMR 663
Query: 423 TLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQE----LSEKL---SK 475
++K E +Q+ ++Q QE +++ E + R +E + +E EK+ +
Sbjct: 664 EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 723
Query: 476 LQQEKEALREEYLRLLKLLNVHVRNYNE 503
+++++E +R++ ++ + L H +E
Sbjct: 724 MREKEERIRDQKEKMQERLPEHEERCSE 751
Score = 43.9 bits (102), Expect = 6e-04
Identities = 65/346 (18%), Positives = 135/346 (39%), Gaps = 65/346 (18%)
Query: 443 QQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALR---EEYLRLLK-----LL 494
++++AL +L +E K N EL EKL + EK ++ +E R L+ L
Sbjct: 166 KERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLP 225
Query: 495 NVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQI 554
V E+ +Q+ +L++ + ++ + E ++ + ++ G ++ + EK + + ++
Sbjct: 226 QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRL 285
Query: 555 TAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQI 614
Q L ++++L+EQ +EQ +Q+QE ++ +Q
Sbjct: 286 REQEKELREQEKELREQKKLREQ----------------------EEQMQEQEEKMWEQ- 322
Query: 615 GFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHE 674
E ++E W +L +++E + + +
Sbjct: 323 --------------EEKMREQEEKMWRQEERLWEQEKQMREQE----QKMRDQEERMWEQ 364
Query: 675 DESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIK 734
DE + E E+ + E+M + E E + E K + E +++E EE
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIRE---------REKKMREEEETMREQEEKM 415
Query: 735 SKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQDQK 780
K+ + EK + + E L E +QEQ++K
Sbjct: 416 QKQEENMWEQEEKEWQQQRLPEQKE-------KLWEQEKMQEQEEK 454
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 99.0 bits (245), Expect = 2e-20
Identities = 134/662 (20%), Positives = 277/662 (41%), Gaps = 96/662 (14%)
Query: 1 MSQEKNEMFESEWSKERE---------REKQLASGLDTAEKALKVESEELQKSKSELICL 51
+SQEK E+ S E R+ L S L L+ + +EL +S SE L
Sbjct: 434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493
Query: 52 YNEVHNLPGES-ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNL 110
E+ L ++ E+ H ++ D L ++ +E ++ + KL Q+
Sbjct: 494 IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDL----------------- 536
Query: 111 ITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKE 170
N+ + + +++ ++ +L +K+K I E + + E
Sbjct: 537 ------------NDE--KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLE 582
Query: 171 EGSQQNRDMKDEEKEQQLTMKPEE------IVRLREELSHINQSLLQSQSSGDSSDDSGA 224
+ + D ++ +E ++++ E I + EELS I L+QS + +S+
Sbjct: 583 DKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFK-- 640
Query: 225 QHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENI 284
+ L ++ EV+ L QNL L+ L N +LK+ ++ EN
Sbjct: 641 ------DTLLKEREAEVRNLKQNLSELEQL--------------NENLKKVAFDVKMENE 680
Query: 285 KIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIK----ELELEVLKHTQSIKSQNNLQE 340
K+ + + + +L + + L+ E + +K E+E E+ + + + N E
Sbjct: 681 KLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYE 740
Query: 341 KLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQY 400
K ++E S + L +LEH H + L E +L++ I++ + + K
Sbjct: 741 KTIEELSNARNLNTSAL----QLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVL 796
Query: 401 QEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYD 460
+++K L Q +++ + L+++ + L+ + +++ E L + +E + R
Sbjct: 797 SSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR--- 853
Query: 461 EHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLT 520
S + E+ + LQ+E E LREE R + + + + + +L +K L
Sbjct: 854 ----SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE 909
Query: 521 NEVELRDKRI-NQFEDEIGILQHKIEKEKAI------QDQITAQNDTLLLEK----RKLQ 569
E++ K I +Q + ++ +LQ E++K + +Q+ A + L LEK + LQ
Sbjct: 910 EEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQ 969
Query: 570 EQVIEQEQLIHSNKWTISSIQSRVLYMDK-ENKQLQENSLRLTQQIGFLERIIRSIHIRR 628
+ + + + +H + I + S + K ++ ++ S + ER+++ I R
Sbjct: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
Query: 629 GE 630
E
Sbjct: 1030 LE 1031
Score = 77.0 bits (188), Expect = 6e-14
Identities = 142/671 (21%), Positives = 274/671 (40%), Gaps = 91/671 (13%)
Query: 174 QQNRDMKDEEKEQQLTM-------KPEEIVRL-REELSHINQ------SLLQSQSSGDSS 219
+QNR + ++ + ++++ K EI R REELS + +LLQ SG
Sbjct: 222 KQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIE 281
Query: 220 DDSGAQHPSSG-----EKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQ 274
D + + K +++QL + + +SAEN+ R + L
Sbjct: 282 TDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNV 341
Query: 275 HNSLLQEENIKIKIELKHAQQKLLDSTKMC---------SSLTAEYKHCQQKIKELELEV 325
+ EE +K+E Q + + S+ E QQ + + E E+
Sbjct: 342 EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI 401
Query: 326 LKHTQSIKSQNNLQEK----------LVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTC 375
++ S+ N+L E L +EKS ++ +E++ KL + ++V +
Sbjct: 402 MR-LSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTA- 459
Query: 376 ISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTC 435
+ L+ ++ + N +Q+ + +++ L ++EL RQ + L++
Sbjct: 460 -TRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
Query: 436 SQQQSRIQQQEALLKQLENEKRK-----YDEHVKSNQELSEKLSKLQQEKEALREEYLRL 490
S+QQ+ + LKQ N+++K D+ + +EL + KL Q + AL + +L
Sbjct: 519 SKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTK 578
Query: 491 LKLLN--VHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEK 548
KL + ++ + K + V +QK L + ++ +++ +E+ +
Sbjct: 579 QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNEL--------MQS 630
Query: 549 AIQDQITAQNDTLLLEK----RKLQEQVIEQEQLIHSNKWTISSI----QSRVLYMDKEN 600
QD + DTLL E+ R L++ + E EQL + K + + VL +
Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVR 690
Query: 601 KQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKL--ASLPPTKKQKEI 658
QL+E Q I+ ++ + +GE E W + +L + K +E+
Sbjct: 691 HQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL----CWAKKRLLEEANKYEKTIEEL 746
Query: 659 YSTEVFTSNNAELQHE------DESVPEATEKWKHSEQMET---TISDILES--EVVNEI 707
+ ++ +L+HE + E E K+ EQM+T D+L S E ++
Sbjct: 747 SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL 806
Query: 708 LPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVAS 767
L N E F +++ +E SK K + +N + Q E ++ S
Sbjct: 807 TQLINKK-------EIF--IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGS 857
Query: 768 LKETHG-IQEQ 777
+KE + +QE+
Sbjct: 858 MKEENNHLQEE 868
Score = 76.3 bits (186), Expect = 1e-13
Identities = 145/664 (21%), Positives = 271/664 (40%), Gaps = 96/664 (14%)
Query: 1 MSQEKNEMFESEWSKERERE----KQLASGLDTAEKALKVESEELQKSKSELICLYNEVH 56
++Q+ N F+ KERE E KQ S L+ + LK + +++ +L+ +V
Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVR 690
Query: 57 N-----LPGESESKDHFLIACDLLQRENSELETKVL---KLSQEFAQLNHFTLGGKTAPS 108
+ L G ++ + L+ E E+E ++ K E A T+ +
Sbjct: 691 HQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNAR 750
Query: 109 NLITSE-----------NTCKDPESNE--PILETEIQSRKEETEELCPKLGERKQ----- 150
NL TS N KD E E +E KE + L L E+KQ
Sbjct: 751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLI 810
Query: 151 --KEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQS 208
KEI E +KE S + + ++ SQ R K+E Q + K + ++EE +H+ +
Sbjct: 811 NKKEIFIEKLKERSSKLQEELDKYSQALR--KNEILRQTIEEKDRSLGSMKEENNHLQEE 868
Query: 209 LLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYER-- 266
L + + + S + P + + V +L + +L + E E+++ +
Sbjct: 869 LERLRE--EQSRTAPVADPKTLDS--------VTELASEVSQLNTIKEHLEEEIKHHQKI 918
Query: 267 --GQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELE 324
QN Q LQE+ ++ +Q T++ E K Q+ I++++ +
Sbjct: 919 IEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQ 978
Query: 325 VLKHTQSIKSQNN--LQEKLVQ--------EKSKVADAEEKILDLQRKLEHAHKVCLTDT 374
+ + Q I++ N+ QE VQ EK ++ AE + L K L +
Sbjct: 979 LHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEK 1038
Query: 375 CISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMT 434
IS +Q+++ K+ ++ QQ E + LH ++ + ++++ +
Sbjct: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLE----------IQALHARISSTSHTQDVVYLQ 1088
Query: 435 CSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLL 494
Q Q+ ++E + L NEK + + H+K+ K+ + KEA L+KL
Sbjct: 1089 -QQLQAYAMEREKVFAVL-NEKTRENSHLKTEYH---KMMDIVAAKEAA------LIKL- 1136
Query: 495 NVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQI 554
++ N+K + + +R T ++ + I + + EI L K + A+
Sbjct: 1137 ----QDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKCQTLLAVLQTS 1190
Query: 555 TAQNDT----------LLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQ 604
+ N+ LL E+ KL++QV + E+ T+ ++Q + +E QLQ
Sbjct: 1191 STGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ 1250
Query: 605 ENSL 608
L
Sbjct: 1251 AQVL 1254
Score = 66.6 bits (161), Expect = 8e-11
Identities = 88/414 (21%), Positives = 178/414 (42%), Gaps = 21/414 (5%)
Query: 6 NEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESK 65
+E+ E + KQL D +K LK E + L K+KS+ + NE N +
Sbjct: 1381 SELERKEHEQTDSEIKQLKEKQDVLQKLLK-EKDLLIKAKSDQLLSSNE--NFTNKVNEN 1437
Query: 66 DHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEP 125
+ A L+ LE + KL E ++ T GK + N E
Sbjct: 1438 ELLRQAVTNLKERILILEMDIGKLKGENEKIVE-TYRGKETEYQALQETNMKFSMMLREK 1496
Query: 126 ILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRD---MKDE 182
E E S KE+ L E++Q + E + + +K QQ RD + +
Sbjct: 1497 --EFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALK 1554
Query: 183 EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
+K+ + T E+ RLR++ NQ L + ++ S+DS + + E + + +V
Sbjct: 1555 QKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVT 1614
Query: 243 QLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTK 302
L + +L N+ EN Q L++ +++ ++ + ++L +Q+++
Sbjct: 1615 VLEE---KLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYAL 1671
Query: 303 MCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRK 362
++L +H QQ+ K + ++ ++ Q L + + K + E K++ LQ
Sbjct: 1672 SLANLQMVLEHFQQEEKAM------YSAELEKQKQL---IAEWKKNAENLEGKVISLQEC 1722
Query: 363 LEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDE 416
L+ A+ + + ++E+ ++E+ E + + +++Q+ ++ QK+ + N E
Sbjct: 1723 LDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1776
Score = 65.9 bits (159), Expect = 1e-10
Identities = 119/551 (21%), Positives = 235/551 (42%), Gaps = 104/551 (18%)
Query: 168 QKEEGSQQNRDMKDEEKEQQLTMK--PEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQ 225
++++ QQ + M++ +++ T++ E +L+EEL LQ+Q DS ++S Q
Sbjct: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ-----LQAQVLVDSDNNSKLQ 1264
Query: 226 HPSSGEKLKYNQQGEV-----QQLHQNLHRLQILCNS----------------------- 257
+G Y Q Q+L Q H + LCN+
Sbjct: 1265 VDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTP 1324
Query: 258 --------AENELRYERGQNL--DLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSL 307
+++E+ E + L +L++ LQE++ I+ L+ +L DS S L
Sbjct: 1325 QSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRT-LQENNHRLSDSIAATSEL 1383
Query: 308 T--------AEYKHCQQK-------IKELELEVLKHTQSIKSQN---------------- 336
+E K ++K +KE +L + + + S N
Sbjct: 1384 ERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQA 1443
Query: 337 --NLQEKLV---QEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQ 391
NL+E+++ + K+ EKI++ R E ++ L +T + L EK E
Sbjct: 1444 VTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQA-LQETNMKFSMMLREKEFECHS 1502
Query: 392 NEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQ 451
+ K Q ++K + +++L V+++Q+K + + Q ++Q++
Sbjct: 1503 MKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTA 1562
Query: 452 LENE-KRKYDEHVKSNQELSEKLSKLQQEKEALREEYL----RLLKLLNVHVRNYNEKHH 506
L+NE +R D+ +SNQEL + L + +++ E L R K L V EK
Sbjct: 1563 LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAK-LRKKVTVLEEKLV 1621
Query: 507 QQKVKLQKVKYRLTNEVELRDKRIN---QFEDEIGILQHKIEKEKAIQDQITAQNDTLLL 563
++ ++ + +VE +++N + DE LQ + +E+ Q ++ N ++L
Sbjct: 1622 SSSNAMENASHQASVQVESLQEQLNVVSKQRDETA-LQLSVSQEQVKQYALSLANLQMVL 1680
Query: 564 EKRKLQEQVI------EQEQLIHSNKWTISSIQSRVL----YMDKENKQLQENSLRLTQQ 613
E + +E+ + +Q+QLI K +++ +V+ +D+ N L +++ RLT+Q
Sbjct: 1681 EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAAL-DSASRLTEQ 1739
Query: 614 IGFLERIIRSI 624
+ E I +
Sbjct: 1740 LDVKEEQIEEL 1750
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 98.6 bits (244), Expect = 2e-20
Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 139/853 (16%)
Query: 4 EKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG--E 61
+K + E + K ++ ++Q LD+ E AL+ + ++++ K+E L E L E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 62 SESKDHFLIACDLLQREN---------SELETKVLKLSQEFAQLNHFTLGGKTAPSNLIT 112
S K I+ +L +E+ + + ++ KL QE + + A +
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 113 SENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKE-- 170
S N C P+ I T + + + L E+ KE+ E E K+
Sbjct: 138 SLNPCNTPQK---IFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKAS 194
Query: 171 ----EGSQQNRDMK-----------DEEKEQQLTMKPEEIVRLREELSHI----NQSLLQ 211
+ + +RD+ +EK + +R + S Q +
Sbjct: 195 QTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTP 254
Query: 212 SQSS---GDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQ 268
S+S+ G +S SS L + + Q+L ++ L++ E E++ + +
Sbjct: 255 SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNK 314
Query: 269 NLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKH 328
+L+ + E I+ + L + +L+ +T + +Y +QK+K+L ++
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 329 TQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCL----------------- 371
Q+ +S E+ ++EK K + +E++ QR + + C+
Sbjct: 375 RQNAESARCSLEQKIKEKEK--EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 372 ------TDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQ 425
D S KQQLE ++E Q + +Q +Q Q K +EL R + ++
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE-------NELRRSMEEMK 485
Query: 426 DKENLLEMTCSQQQSRIQQQEALLKQLE---NEKRKYDEHVKSNQELSEKL-----SKLQ 477
+ NLL+ Q+ + EA LK ++ N+ + + E +K+ E + K+
Sbjct: 486 KENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN 545
Query: 478 QEKEALREEYLR---------------LLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNE 522
Q++ +L E L+ LLK H+ N+K K +K L +
Sbjct: 546 QQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK----LSKTEKESKALLSA 601
Query: 523 VELRDKRINQFEDEIGILQ-HKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHS 581
+EL+ K + ++E + K E EK + + EK LQ ++ E + +
Sbjct: 602 LELKKKEYEELKEEKTLFSCWKSENEKLLTQMES--------EKENLQSKINHLETCLKT 653
Query: 582 NKWTISSIQSRV--LYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPK 639
+ RV L MD+EN ++ IR++H E K
Sbjct: 654 QQIKSHEYNERVRTLEMDRENLSVE----------------IRNLHNVLDSKSVEVETQK 697
Query: 640 --WWHRGKLASLPPTKKQKEI----YSTEVFTSNNAELQHE----DESVPEATEKWKHSE 689
+ + A K QKEI T T +L+H+ + + ++
Sbjct: 698 LAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLH 757
Query: 690 QMETTISDILESE----VVNEILPLSNSSFSGK-GLVESFASLQETEEIKSKEAMASSKS 744
++ D+L+S+ V NE S +F + + SFA++ + E
Sbjct: 758 AEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLE 817
Query: 745 PEKSPENLVCSQN 757
++SP+N QN
Sbjct: 818 ADQSPKNSAILQN 830
Score = 97.8 bits (242), Expect = 3e-20
Identities = 165/811 (20%), Positives = 341/811 (42%), Gaps = 99/811 (12%)
Query: 2 SQEKNEMFESEWSKEREREK-QLASGLDTAEKALKVESE-------ELQKSKSELICLYN 53
+ EK ++ +E KERERE L ++ E+ L++ E + + SK+E+ L
Sbjct: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT 2189
Query: 54 EVHNLPGESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITS 113
++ + + S F + L+ E L ++ + + ++L+ K+ +
Sbjct: 2190 QIEEM---ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA 2246
Query: 114 ENTCKDPESNE-PILETEIQSRKEETEELCPKLGERKQKE------IPEESVKEGSFPRE 166
E K+ +L+ +++ E LC K E I EE S +
Sbjct: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
Query: 167 GQKEEGSQQN-----RDMKDEEKEQQLTMKPEEIVRLREELSHINQ--SLLQSQSSGDSS 219
+ E ++ + +K+ E L E + E++ NQ + L++++S
Sbjct: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366
Query: 220 DDSGAQHPSSGEKL-------------KYNQQGEVQQLHQNLHRLQILCNSAENELRYER 266
+ A+ + L K N E+Q+ + + L+I+ +S EN L+ +
Sbjct: 2367 ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426
Query: 267 GQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVL 326
+ + +K+ +S E ++ +LK +++ + A+ ++ +++ LELE
Sbjct: 2427 QEKVQMKEKSSTAME---MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKA 2483
Query: 327 KHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKI 386
+ Q + N + +S V +++ D ++KLE + E +L+ +I
Sbjct: 2484 QLLQGLDEAKN---NYIVLQSSVNGLIQEVEDGKQKLEKKDE---------EISRLKNQI 2531
Query: 387 KEATQNEAKVKQQYQEEQ--QKRKLLYQNVD-ELHRQVRTLQDKENLLEMTCSQQQSRIQ 443
++ Q +K+ Q E Q +++ L +N+ EL ++++ LQ K L+ T QS +
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2591
Query: 444 QQEALLKQLENEKRKYDEHV-----------KSNQELSEKLSKLQQEKEALREEYLRLLK 492
E L+ + +K + E V + E+++K ++LQ+E + L+
Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 2651
Query: 493 LLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKI-EKEKAIQ 551
LL +++ ++ + ++ ++K L + + ++ + +EI Q ++ E EK Q
Sbjct: 2652 LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ 2711
Query: 552 DQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLT 611
+ N +E + +E++ +E+ + S K I + K +K+ NSL+ T
Sbjct: 2712 ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLL--------KSSKEELNNSLKAT 2763
Query: 612 QQIGFLERIIRSIHIRRGENLK---EFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNN 668
QI LE + ++ + +NLK + +GK+ L + KQ E
Sbjct: 2764 TQI--LEELKKT----KMDNLKYVNQLKKENERAQGKMKLLIKSCKQLE--------EEK 2809
Query: 669 AELQHEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQ 728
LQ E + A EK K M+T + D L +E+ L + ++ + SL
Sbjct: 2810 EILQKELSQLQAAQEKQKTGTVMDTKV-DELTTEIKELKETLEEKTKEADEYLDKYCSL- 2867
Query: 729 ETEEIKSKEAMASSKSPEKSPENLVCSQNSE 759
+ S E + +K ++ +CSQ S+
Sbjct: 2868 ----LISHEKLEKAKEMLETQVAHLCSQQSK 2894
Score = 77.4 bits (189), Expect = 5e-14
Identities = 164/796 (20%), Positives = 330/796 (41%), Gaps = 109/796 (13%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
K +E+ ++L S ++V E+++ L L ++V L + K H
Sbjct: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSEL---LKDKTHLQEKLQS 2039
Query: 75 LQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSR 134
L++++ L +L + AQLN E K+ ES +Q+R
Sbjct: 2040 LEKDSQALSLTKCELENQIAQLNK-------------EKELLVKESES--------LQAR 2078
Query: 135 KEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMK--------DEEKEQ 186
E++ KL K E E + +EE Q R ++ DE+K+
Sbjct: 2079 LSESDY--EKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2136
Query: 187 QLTMKPEEIVR----LREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
+ K +E R L++++ ++ + L S+ + + + E LK + +
Sbjct: 2137 HIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMAR 2196
Query: 243 QLHQNLHRLQILCNSAEN---ELRYERGQ--NLD--LKQHNSLLQEEN---IKIKIELKH 292
L L L + EN +++ ++GQ LD L SLL+E+ I+IK E K
Sbjct: 2197 SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKT 2256
Query: 293 AQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKV-AD 351
A + L + K + A Q+ +K E + I+ ++ L+ + + ++++ AD
Sbjct: 2257 AVEMLQNQLKELNEAVAALCGDQEIMKATEQSL---DPPIEEEHQLRNSIEKLRARLEAD 2313
Query: 352 AEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLY 411
++++ LQ+ E H D + LE +++ A N+ + + + + + L
Sbjct: 2314 EKKQLCVLQQLKESEHHA---DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLK 2370
Query: 412 QNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSE 471
++ + + +R L+ L++ + + +E L +L+ E+ + E N
Sbjct: 2371 AKIEGMTQSLRGLE-----LDVVTIRSE-----KENLTNELQKEQERISELEIINSSFEN 2420
Query: 472 KLSKLQQEKEALREEYLRLLKLLNVHVRNYNEK----HHQQKVKLQKVKYRLTNEV---E 524
L + +QEK ++E+ +++L ++ NE+ H+ Q+ K + L+++V E
Sbjct: 2421 ILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK-EQNLSSQVECLE 2479
Query: 525 LRDKRINQFEDEIGILQHKIEKEKAIQDQITAQND-TLLLEKR-----KLQEQVIEQEQL 578
L ++ Q DE + I + ++ I D LEK+ +L+ Q+ +QEQL
Sbjct: 2480 LEKAQLLQGLDE--AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537
Query: 579 IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVP 638
+ S++ ++ E++ +E +L L LE+ I+ + + V
Sbjct: 2538 V-----------SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVL 2586
Query: 639 KWWHRGKLASLPPTKKQKEIYSTEV--FTSNNAELQHEDESVPEAT---------EKWKH 687
+ ++ L TK K + +V T+ ELQ E + + T EK +
Sbjct: 2587 QSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRL 2646
Query: 688 SEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSK---- 743
+ +++ + +I S+ + L L NS K ++ Q +E K +E +A +
Sbjct: 2647 AGELQLLLEEIKSSKDQLKELTLENSEL--KKSLDCMHKDQVEKEGKVREEIAEYQLRLH 2704
Query: 744 SPEKSPENLVCSQNSE 759
EK + L+ N +
Sbjct: 2705 EAEKKHQALLLDTNKQ 2720
Score = 72.0 bits (175), Expect = 2e-12
Identities = 159/750 (21%), Positives = 301/750 (40%), Gaps = 104/750 (13%)
Query: 75 LQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSE-NTCKDPESNEPILETEIQS 133
L++ENS+L K+ E+ +H L + S + S+ D S E I + +
Sbjct: 1835 LKKENSDLSEKL-----EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889
Query: 134 RKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDM-KDEEKEQQLTMKP 192
E E + + S++ + E E + + KD E +Q++
Sbjct: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV---- 1945
Query: 193 EEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQ 252
IV L EELS + Q + D+ EK+K Q + LH +Q
Sbjct: 1946 --IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ 2003
Query: 253 ILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYK 312
+ AE E++ + +L Q S E +K K H Q+KL K +L+
Sbjct: 2004 V----AEAEVK----EKTELLQTLSSDVSELLKDK---THLQEKLQSLEKDSQALSLTKC 2052
Query: 313 HCQQKIKEL--ELEVLKHTQSIKSQNNLQEKLVQ---EKSKVADAEEKILDLQRKLEHAH 367
+ +I +L E E+L +K +LQ +L + EK V+ A E L K E A
Sbjct: 2053 ELENQIAQLNKEKELL-----VKESESLQARLSESDYEKLNVSKALEAA--LVEKGEFAL 2105
Query: 368 KVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDK 427
++ T +E++ + + K++ + + +++K+ + + + E R+ +L+DK
Sbjct: 2106 RLSST----------QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 428 ENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEY 487
LE + Q + QE ++ EN K + + +E++ L + + LR E
Sbjct: 2156 VENLE---RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 488 LRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDE----IGILQHK 543
L K + ++ Q +L K+ + +E +++ Q ++E + +LQ++
Sbjct: 2213 ENLTKQI--------QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ 2264
Query: 544 IEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKEN--- 600
+++ + + + ++ L + E+ QL +S I +++R+ +K+
Sbjct: 2265 LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS----IEKLRARLEADEKKQLCV 2320
Query: 601 -KQLQENSLRLTQQIGFLERIIRSIHIRR---------GENLK-EFPVPKWWHRGKLASL 649
+QL+E+ G +E + R + I R EN K E K G SL
Sbjct: 2321 LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
Query: 650 PPTKKQKEIYSTEVFTSNNAELQHEDESVPE-----------ATEKWKHSEQMETTISDI 698
+ +E N ELQ E E + E EK + QM+ S
Sbjct: 2381 RGLELDVVTIRSEKENLTN-ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439
Query: 699 LE------SEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENL 752
+E E+ + L N + K ++ +S E E++ + + + +++ N
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL---QGLDEAKNNY 2496
Query: 753 VCSQNSEAGYINVASLKETHGIQEQDQKSE 782
+ Q+S G I + G Q+ ++K E
Sbjct: 2497 IVLQSSVNGLIQ----EVEDGKQKLEKKDE 2522
Score = 69.3 bits (168), Expect = 1e-11
Identities = 165/837 (19%), Positives = 330/837 (39%), Gaps = 147/837 (17%)
Query: 10 ESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELI---CLYNEVHNLPGESESKD 66
E E + + ++L L+ A+ L + + L K + EL+ Y++ E K
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
Query: 67 HFLIACDLLQRENSE-----LETKVLKLSQEFAQ-LNHFTLGGKTAPSNLITSE----NT 116
L QR+N+E LE K+ + +EF + L+ +T I +
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
Query: 117 CKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQN 176
+ ++ +L+ E+ ++L L E KQK E + S +E ++
Sbjct: 425 LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE------NELR 478
Query: 177 RDMKDEEKEQQLT-----MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGE 231
R M++ +KE L K E+ L EL +I Q L QSQ+ + +S E
Sbjct: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN----TSQE 534
Query: 232 KLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIK---- 287
+ + Q ++ Q +L ++ A+ E + + Q+L LK+ +++ N K+
Sbjct: 535 TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL-LKKREHHIEQLNDKLSKTEK 593
Query: 288 --------IELKHAQQKLL------------DSTKMCSSLTAEYKHCQQKIKELELEVLK 327
+ELK + + L ++ K+ + + +E ++ Q KI LE LK
Sbjct: 594 ESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET-CLK 652
Query: 328 HTQSIKSQN--------------------NLQEKLVQEKSKVADAEEKILDLQRKLEHA- 366
TQ IKS NL L + +V + ++LQ+K E +
Sbjct: 653 -TQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD 711
Query: 367 --HKVCLTDTCISEKQ------QLEEKIKEATQNEAKVKQQYQ----------------- 401
H+ + + C+ Q LE K++ + + YQ
Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
Query: 402 ------EEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENE 455
E+ Q+ L + +H + ++ + S+ + Q L+N
Sbjct: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
Query: 456 KRKYDEHVKSNQELSEKLSKLQQEKEALREEYLR-LLKLLNVHVRNYNEKHHQQKVKLQK 514
+ ++S ++++ L K +E ++ E L+K +H +++ + Q+ KLQ+
Sbjct: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMH-QSFVAETSQRISKLQE 890
Query: 515 VKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIE 574
N V + E E+ +L K+E E+A ++ N L E ++
Sbjct: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLL--------EDSLK 942
Query: 575 QEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIH------IRR 628
+ QL+ S ++ ++K ++++E LTQ+ G L+ I S++ I++
Sbjct: 943 ELQLLSETLSLEKKEMSSIISLNK--REIEE----LTQENGTLKEINASLNQEKMNLIQK 996
Query: 629 GENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHS 688
E+ + + ++ L KQ+++ + + + + ++K+K +
Sbjct: 997 SESFANYIDER---EKSISELSDQYKQEKLILLQ-------RCEETGNAYEDLSQKYKAA 1046
Query: 689 EQMETTISDILESEVVNEILPL-SNSSFSGKGLVESFASLQETEEIKSKEAMASSKS 744
++ + + +L NE L N + L E+FA +E +E +K A A ++
Sbjct: 1047 QEKNSKLECLL-----NECTSLCENRKNELEQLKEAFA--KEHQEFLTKLAFAEERN 1096
Score = 68.6 bits (166), Expect = 2e-11
Identities = 170/838 (20%), Positives = 340/838 (40%), Gaps = 143/838 (17%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNE-VHNLPGE 61
+ +NE ++ E+E + + L+T K +++S E YNE V L
Sbjct: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE-----------YNERVRTLE-- 669
Query: 62 SESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPE 121
+ REN +E + L H L K+
Sbjct: 670 -------------MDRENLSVEIRNL----------HNVLDSKSV-------------EV 693
Query: 122 SNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKD 181
+ + E+Q + E ++ ++ QKEI +K + + E Q +
Sbjct: 694 ETQKLAYMELQQKAEFSD-------QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEI 746
Query: 182 EEKEQQLTMKPEEIVRLREELSHINQSLLQS---QSSGDSSDDSGAQHPSSGEKLKYNQQ 238
+K++ E LR+ L + SL+ + Q S + D A H S + +Q
Sbjct: 747 MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANII--GEQ 804
Query: 239 G-----------EVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIK 287
G E Q +N LQ +S E L ++ N DL++ EE ++IK
Sbjct: 805 GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ----CEELVQIK 860
Query: 288 IELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKH----TQSIKSQNNLQEKLV 343
E+ ++ L+ + +M S AE Q+I +L+ + H +++ + N +++L
Sbjct: 861 GEI---EENLMKAEQMHQSFVAE---TSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
Query: 344 QEKSKVADAEEKILDLQRK---LEHAHK--VCLTDTCISEKQQL-------EEKIKEATQ 391
KV + +I +L++ LE + K L++T EK+++ + +I+E TQ
Sbjct: 915 LLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 974
Query: 392 NEAKVKQQYQEEQQKRKLLYQN-------VDELHRQVRTLQD----KENLLEMTCSQQQS 440
+K+ Q++ L Q +DE + + L D ++ +L C + +
Sbjct: 975 ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGN 1034
Query: 441 RIQQQEALLKQLENEKRKYDEHVKSNQELSE-KLSKLQQEKEALREEYLRLL-KLLNVHV 498
+ K + + K + + L E + ++L+Q KEA +E+ L KL
Sbjct: 1035 AYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEE 1094
Query: 499 RNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEK-EKAIQDQITAQ 557
RN N + V+ Q ++ +T+ + EI L+ + K +K + D +
Sbjct: 1095 RNQNLMLELETVQ-QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
Query: 558 NDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSL-RLTQQIGF 616
+ + K K + Q +E E + +S K S +++ + + + +++E SL Q+
Sbjct: 1154 EQLMKVMKTKHECQNLESEPIRNSVK-ERESERNQCNFKPQMDLEVKEISLDSYNAQLVQ 1212
Query: 617 LERIIRSIHIRRGENLKEFPVPKWWHRGKLASLP---PTKKQKEIYSTEVFTSNNAELQH 673
LE ++R+ ++ E+ KE K + +L ++ T +++ S E+ + E+
Sbjct: 1213 LEAMLRNKELKLQESEKE----KECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDA 1268
Query: 674 EDESVPEATEKWKHSE-------QMETTISDILESEVVNEILPLSNSSFSGKGLVESFAS 726
E++ + E ++TT++ + E E + EIL E +
Sbjct: 1269 EEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ-----------AEKYEL 1317
Query: 727 LQETEEIKSKEAMASSKSPEKSPE--NLVCSQNSEAGYINVASLKETHGIQEQDQKSE 782
+ E + +S+ A+ K E+ + N V N ++G ++ +++ G + +Q +E
Sbjct: 1318 VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNE 1375
Score = 60.1 bits (144), Expect = 8e-09
Identities = 124/613 (20%), Positives = 238/613 (38%), Gaps = 117/613 (19%)
Query: 4 EKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQK-SKSELICLYNEVHNLPGES 62
++++ F ++ + ER + L L+T ++AL+ E + Q SKSE L E+ L E
Sbjct: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCK-DPE 121
+ DLLQ EN +L KV+K E L + + + + N C P+
Sbjct: 1140 NKMQKEVN--DLLQ-ENEQL-MKVMKTKHECQNLESEPI--RNSVKERESERNQCNFKPQ 1193
Query: 122 SNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKE----------GSFPREGQKEE 171
+ + E + S + +L L ++ K E KE G ++
Sbjct: 1194 MDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDM 1253
Query: 172 GSQQNRDMKDEE--KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSS 229
SQ+ +KD E E++ P E+ + + +H+ SL + + +
Sbjct: 1254 QSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNEL---------- 1303
Query: 230 GEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLD----LKQHNSLLQEENIK 285
EK+ Q E +L L+ + C +A ++ E G+ L+ L + LL E ++
Sbjct: 1304 -EKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
Query: 286 ------------------------------IKIELKHAQQKLLDSTKMCSSLTAEYK--- 312
+ + K Q + + SL +E+K
Sbjct: 1363 DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILH 1422
Query: 313 --HCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVC 370
HCQ K EL+ + S+K++N LV + + + ++Q LE
Sbjct: 1423 DQHCQMSSKMSELQT--YVDSLKAEN-----LVLSTNLRNFQGDLVKEMQLGLEEGLVPS 1475
Query: 371 LTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQ----------NVDELHRQ 420
L+ +C+ + L ++ ++ + E+ LL +VDE+
Sbjct: 1476 LSSSCVPDSSSL------SSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVF-- 1527
Query: 421 VRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSN--------QELSEK 472
+LQ++ + T S +++ E+L + K +E ++S QEL +
Sbjct: 1528 CSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL 1587
Query: 473 LSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQ 532
LS +QE + LR++YL ++ Q + KL V + +++ K+ Q
Sbjct: 1588 LSSERQELDCLRKQYL--------------SENEQWQQKLTSVTLEMESKLAAEKKQTEQ 1633
Query: 533 FEDEIGILQHKIE 545
E+ + + +++
Sbjct: 1634 LSLELEVARLQLQ 1646
Score = 50.8 bits (120), Expect = 5e-06
Identities = 129/626 (20%), Positives = 242/626 (38%), Gaps = 133/626 (21%)
Query: 14 SKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNE-----------VHNLPGES 62
S E+ EK + G+ ++ ++E + L + EL CL + + ++ E
Sbjct: 1562 SLEKLEEKMESQGIMKNKEIQELE-QLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM 1620
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPES 122
ESK +A + Q E LE +V +L + L+ +L G + +C S
Sbjct: 1621 ESK----LAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDI--S 1674
Query: 123 NEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDE 182
E ET ++ K + ++C K ++ E+ + G+ G E +Q+ D E
Sbjct: 1675 KEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTG--ECSGEQSPDTNYE 1732
Query: 183 EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
+ T E + ELS + L + +D +N Q V+
Sbjct: 1733 PPGEDKTQGSSECI---SELSFSGPNALVPMDFLGNQEDI------------HNLQLRVK 1777
Query: 243 QL-HQNLHRLQIL------CNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQ 295
+ ++NL L ++ S NE++ LD K H LQE + KIE +
Sbjct: 1778 ETSNENLRLLHVIEDRDRKVESLLNEMK-----ELDSKLH---LQEVQLMTKIEACIELE 1829
Query: 296 KLLDSTKMCSSLTAE---YKHC--QQKIKELEL-EVLKHTQSIKSQNNLQEKLVQEKSKV 349
K++ K +S +E Y C Q+ ++ +E E L + + + +E + +KV
Sbjct: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889
Query: 350 ADA-EEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRK 408
D+ +E+ LD++ +L SEK +E EA EA + E Q K
Sbjct: 1890 NDSWKERFLDVENELSRIR---------SEKASIEH---EALYLEADL-----EVVQTEK 1932
Query: 409 LLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQE 468
L + +E ++V + C +++ + E QL E + + +
Sbjct: 1933 LCLEKDNENKQKV-----------IVCLEEELSVVTSER--NQLRGELDTMSKKTTALDQ 1979
Query: 469 LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDK 528
LSEK+ + QE E+ + E L +++ V+
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVK----------------------------- 2010
Query: 529 RINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISS 588
EK + +Q +++ LL +K LQE++ E+ + T
Sbjct: 2011 ----------------EKTELLQT-LSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCE 2053
Query: 589 IQSRVLYMDKENKQLQENSLRLTQQI 614
+++++ ++KE + L + S L ++
Sbjct: 2054 LENQIAQLNKEKELLVKESESLQARL 2079
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 96.3 bits (238), Expect = 1e-19
Identities = 184/837 (21%), Positives = 349/837 (41%), Gaps = 94/837 (11%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
+ +E ES S+ +++++ L L+ AE+ E + +Q+ L + G
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160
Query: 61 ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
E + L +++ E++ L QL FT K+ S + +
Sbjct: 2161 EIQVT---------LNKKDKEVQQLQENLDSTVTQLAAFT---KSMSSLQDDRDRVIDEA 2208
Query: 121 ESNEPILETEIQSRKEET---EELCPKLGER-KQKEIPEESVKEGSFPREGQKE--EGSQ 174
+ E IQS++EE E+ C L ++ +Q I E +K E K+ E
Sbjct: 2209 KKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKA 2268
Query: 175 QNRDMKDEEKEQQLTMKPEEIVRLREELSHINQS----LLQSQSSGDSSDDSGAQHPSSG 230
Q ++ L + +E++ EE H+ S L + +S S D +S
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328
Query: 231 EKLKY---NQQGEVQQLHQNLHRLQILCNSAENELRYERG------QNLDLKQHN--SLL 279
EK K N +G ++Q ++ + E +L+ R + +++K+ SLL
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLL 2388
Query: 280 --QEENIKIKI---------ELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKH 328
+EE I++ I E+K + L + L E K K +L +E LK
Sbjct: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL-METLKT 2447
Query: 329 TQSIKSQNNLQ-EKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIK 387
+ Q Q + V+ S + + ++I+ ++LE H + I EK QL I+
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHL-----SIILEKDQL---IQ 2499
Query: 388 EATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ-VRTLQDKENLLEMTCSQQQSRIQQQE 446
EA K+K++ + + L +L + ++ +D ++ + SQQ+ ++ Q
Sbjct: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQL 2559
Query: 447 ALLKQLENEKRKYDEHVKSNQELSEKLSK----LQQEKEALREEYLRL---LKLLNVHVR 499
K+LEN+ K +E +K ++E +E L + LQ+EK+ L +E L + L V
Sbjct: 2560 QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619
Query: 500 NYNEK------HHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKA-IQD 552
E+ H Q KVK ++V +RL+ KRI + E+E+ +Q + K+ I+D
Sbjct: 2620 ALQEEGTLGLYHAQLKVKEEEV-HRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED 2678
Query: 553 QITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQ 612
++ + L + ++ + E+ + + ++ ++L + KENK LT
Sbjct: 2679 KLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENK-------GLTA 2731
Query: 613 QIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQ------KEIYSTEVFTS 666
QI R + S+ R +E K + L L K+Q ++ +E S
Sbjct: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
Query: 667 NNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKG----LVE 722
N+ ++ + + ++ ++ +S LE + N++ S + S + L
Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLE-DSYNQVQSFSKAMASLQNERDHLWN 2850
Query: 723 SFASLQETEEIKSKEAMASSKSPE--KSPENLVCSQNSEAGYINVASLKETHGIQEQ 777
+++EE K + A S SP +S + + S ++ + LKE +Q+Q
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRL----LKELKNLQQQ 2903
Score = 87.4 bits (215), Expect = 5e-17
Identities = 139/654 (21%), Positives = 273/654 (41%), Gaps = 86/654 (13%)
Query: 2 SQEKNEMFESEWSKEREREKQLASGLDTA-------EKALKVESEELQKSKSELICLYNE 54
SQ + ESE +++ L++ L+ E ++ + ++Q SK L +
Sbjct: 2303 SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD 2362
Query: 55 VH-------NLPGESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAP 107
+ L E K+ +I+ LL + ++ + +L Q+ +
Sbjct: 2363 LQASRELTSRLHEEINMKEQKIIS--LLSGKEEAIQVAIAELRQQHDK------------ 2408
Query: 108 SNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEG------ 161
+ EN E +LE E + ++T +L L K++ I +++ +
Sbjct: 2409 -EIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS 2467
Query: 162 SFPREGQKEEGSQQNRDMKDE----EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGD 217
S + + G Q + + EK+Q + E +L+EE+ + + S
Sbjct: 2468 SLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENA 2527
Query: 218 SSDDSGAQHPSSGEK---LKYNQQGEVQ--QLHQNLHRLQILCNSAENELRYERGQNLDL 272
D Q+ + +K +QQ ++ QL QN L+ E +L+ N DL
Sbjct: 2528 KLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQN-KELENKYAKLEEKLKESEEANEDL 2586
Query: 273 KQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAE----YKHCQQKIKELELEVLK- 327
++ + LQEE + E++ + + T+ ++L E H Q K+KE E+ L
Sbjct: 2587 RRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSA 2646
Query: 328 -HTQSIKSQNNLQEKLV----QEKSKVADAEEKILDLQRKLEHAHKVCLTDTCI--SEKQ 380
+ S K L+E+LV + KV + E+K L+++L+H H D I +E +
Sbjct: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIEDK---LKKELKHLHH----DAGIMRNETE 2699
Query: 381 QLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQS 440
EE++ E ++ +++Q+ ++ K L + R + +LQ+ S
Sbjct: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN-------------S 2746
Query: 441 RIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRN 500
R E +L+ KRKYD +K +L E+ L +E++AL E + + +
Sbjct: 2747 RDHANE----ELDELKRKYDASLKELAQLKEQ-GLLNRERDALLSETAFSMNSTEENSLS 2801
Query: 501 YNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDT 560
+ EK +QQ + + L++++E ++ F + LQ++ + ++ +
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG 2861
Query: 561 LLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQI 614
K++ Q + S K +SS+Q+ + KE K LQ+ L++ Q+I
Sbjct: 2862 ----KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEI 2911
Score = 86.7 bits (213), Expect = 8e-17
Identities = 148/731 (20%), Positives = 304/731 (41%), Gaps = 135/731 (18%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVES---EELQKSKSELICLYNEVHN 57
M Q+ E+ E +K++ + K L + L + ++ALK EEL ++ + L + +
Sbjct: 1464 MKQKPEEIGEESRAKQQIQRK-LQAALISRKEALKENKSLQEELSLARGTIERLTKSLAD 1522
Query: 58 LPGE----SESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITS 113
+ + ++ KD L LLQ E +L T++ + +L+ +
Sbjct: 1523 VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR--------------------SLLEN 1562
Query: 114 ENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGS 173
++ ES L+ ++ E+ E+L ++ K +I E + E Q++
Sbjct: 1563 QSLSSSCES----LKLALEGLTEDKEKLVKEIESLKSSKIAEST--------EWQEKH-- 1608
Query: 174 QQNRDMKDEEKEQQLTMKP-EEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEK 232
K+ +KE ++ ++ E + E + H+ +++ Q + S + EK
Sbjct: 1609 ------KELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK 1662
Query: 233 LKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSL-LQEENIKIKIELK 291
+ E++++ + + + KQ L L+EEN +++ E+
Sbjct: 1663 QLQEAEQEMEEMKEKMRKFA------------------KSKQQKILELEEENDRLRAEVH 1704
Query: 292 HAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVL-KHTQSIKSQ-NNLQEKLVQEKSKV 349
A + + S A K +++K +E E L K QS+ S+ ++L E++ K ++
Sbjct: 1705 PAGDTAKECMETLLSSNASMKEELERVK-MEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 350 ADAEEKILDLQRKLEHAHKVCLTDT---------------CISEKQQLEEKIKEATQNEA 394
K +L+ +H ++ +T+ +S + E + A
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 395 KVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKEN-------LLEMTCSQQQSRIQQQEA 447
V + + + L Q +D+L ++ L++++ LE + S+I ++
Sbjct: 1824 AVSKDFSSHDEINNYL-QQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDG 1882
Query: 448 LLKQLENEKRKYDEHVKSNQELSEKLSKL-------QQEKEALREEYLRLLKLLNVHVRN 500
LK L+ E K + NQ++ E+LS++ ++EK+ L E + L LN + N
Sbjct: 1883 ELKMLQEEVTKMN---LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN 1939
Query: 501 YNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDT 560
Y + ++K + L +E++ K +++ E+E K++ ++++ ++
Sbjct: 1940 YCQDVTDAQIKNEL----LESEMKNLKKCVSELEEE---------KQQLVKEKTKVES-- 1984
Query: 561 LLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERI 620
E RK + I+ Q NK +Q + +E KQLQ++ +R ++I LER
Sbjct: 1985 ---EIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT 2041
Query: 621 IRSIHIRRGENLKEFPVPK------WWHRGK----LASLPPTKKQKEIYSTEVFTSN--- 667
++++ + E+ K+ + K HR K LAS + + V N
Sbjct: 2042 VKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101
Query: 668 NAELQHEDESV 678
ELQ ESV
Sbjct: 2102 KKELQSNKESV 2112
Score = 81.6 bits (200), Expect = 3e-15
Identities = 184/906 (20%), Positives = 372/906 (41%), Gaps = 160/906 (17%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEE-------LQKSKSEL--ICLYN 53
QE+ ++ + + + +L S E+ K E EE LQK+ EL C
Sbjct: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL 398
Query: 54 EVHNLPGESESKDHFLIACDLLQRENSELETKVLKLSQEFAQL---NHFTLGGKTAP--- 107
+ N + + + + +Q+ +L+ K ++SQ +L H T + P
Sbjct: 399 KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVY 458
Query: 108 ---SNLITSENTCK--------DPESNEPILET-EIQSRKEETEELCPKL---------G 146
+ +T EN + E +L + E++ K E E+L ++ G
Sbjct: 459 NEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTG 518
Query: 147 ERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHIN 206
E +E+ E S+ + + R EE Q + +K ++L++ E+ +EE++
Sbjct: 519 EA-DREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIA--- 574
Query: 207 QSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ-------LHQNLHRLQILCNSAE 259
L+ Q G +++ A H +K +GE L ++ N
Sbjct: 575 --FLKLQLQGKRAEE--ADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEES 630
Query: 260 NELRYERGQNLDLKQHNSLLQEENIKIK---IELKHAQQKLLDSTKMCSSLTAEYKHCQQ 316
+ E+ Q +H S EE I + +ELK +Q D K S++ + Q
Sbjct: 631 SLPAVEKEQAST--EHQSRTSEE-ISLNDAGVELKSTKQ---DGDKSLSAVPDIGQCHQD 684
Query: 317 KIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCI 376
+++ L+ ++L+ + + EK + EK+K ++++ +K + T
Sbjct: 685 ELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFT-ALS 743
Query: 377 SEKQQLEEKIKE---ATQNEAKVKQ---QYQEEQQKRKLLYQN--------VDELHR--- 419
E+ QL ++KE T+ A+VKQ E +++R+L Y++ +++H
Sbjct: 744 EERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 420 -------QVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEK 472
++ LQ++ + +++ S+Q + I+ ++ L+ E+E + E V+ E+
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
Query: 473 LSKL--QQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNE-VELRDKR 529
LS+ Q+E E + + L L K +V + Q+V ++ + +T + V+L +++
Sbjct: 864 LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQV--TEISFSMTEKMVQLNEEK 921
Query: 530 ------INQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNK 583
I ++++ +L E+A ++Q+ N+ K+ E + + +
Sbjct: 922 FSLGVEIKTLKEQLNLLS---RAEEAKKEQVEEDNEVSSGLKQNYDE-------MSPAGQ 971
Query: 584 WTISSIQSRVLYMDKENKQLQE-------NSLRLTQQIGFLERIIRSIHIRRGENLKEFP 636
+ +Q + KEN+Q + N L Q++ LE + ++ + E+ KE P
Sbjct: 972 ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANL---KDESKKEIP 1028
Query: 637 VPKWWHRGKLASLPPTK-----------KQKEIYSTEVFTSNNAELQHEDESVPE---AT 682
+ + RG++ K ++ EIY + + ELQH + + E A
Sbjct: 1029 LSE-TERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087
Query: 683 EKWKH-SEQMETTISD-----------ILESEVVNEILPLSNSSFSGKGLVESFASLQET 730
E+++ +QM T+ D I E++ + + L SN+ S +S A ++ET
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDG---DSVALVKET 1144
Query: 731 EEIK--------------SKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQE 776
I ++ +A K E+ + L + S + A KE H +E
Sbjct: 1145 VVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREE 1204
Query: 777 QDQKSE 782
Q+ +
Sbjct: 1205 LKQQKD 1210
Score = 74.7 bits (182), Expect = 3e-13
Identities = 173/851 (20%), Positives = 324/851 (38%), Gaps = 129/851 (15%)
Query: 3 QEKNEMF---ESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELIC--------L 51
QEK E++ S + ++E EKQL E+ +K + + KSK + I L
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEE-MKEKMRKFAKSKQQKILELEEENDRL 1699
Query: 52 YNEVHNLPGESESKDHFLIACDL-----LQRENSELETKVLK----------LSQEFAQL 96
EVH ++ L++ + L+R E ET K LS+E L
Sbjct: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
Query: 97 NHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEE 156
H G + +NL +E D ++N + E QS ETEE ++
Sbjct: 1760 KHQIEGNVSKQANLEATEK--HDNQTN--VTEEGTQSIPGETEE--------------QD 1801
Query: 157 SVKEGSFPR--EGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQS 214
S+ + P E S KD ++ ++I +L+E ++ + + + Q
Sbjct: 1802 SLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE---EKQK 1858
Query: 215 SGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQ 274
+ + S + + ++ + GE++ L + + ++ +L + EL ++
Sbjct: 1859 NKEFSQTLENEKNTLLSQIS-TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE 1917
Query: 275 HNSLLQEENIKIKIELKHAQ----QKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQ 330
L+E + EL + Q + D+ L +E K+ ++ + ELE E Q
Sbjct: 1918 EKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE---KQQ 1974
Query: 331 SIKSQNNLQEKLVQE--------------KSKVADAEEKILDLQRKLEHAHKVCLTDTCI 376
+K + ++ ++ +E KS + +E + + Q++++ K C+
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI----- 2029
Query: 377 SEKQQLEEKIKEATQNEAKVKQQYQEEQQK-----RKLLYQNVDELHRQVRTLQDKENLL 431
+ +EKI A + K + Q E QK ++ L Q V+ + L + LL
Sbjct: 2030 ----RYQEKIS-ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
Query: 432 EMTCSQQQSRIQQQEALLKQLENEKRKY-------------------DEHVKSNQELSEK 472
+ T S+ + L K+L++ K ++H+K + + EK
Sbjct: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
Query: 473 LSKLQQEKEALREEYLRLLKLLN---VHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKR 529
L L++EK L E + LN V+ E +L +++ + RD+
Sbjct: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
Query: 530 INQ-------FEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSN 582
I++ F D I Q K E+ + +D + D L ++E I +L H
Sbjct: 2205 IDEAKKWERKFSDAI---QSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
Query: 583 KWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWH 642
+ S Q+ V K LQ + L Q+ + S + E K
Sbjct: 2262 QIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321
Query: 643 RGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESE 702
SL K+QK + A++Q+ S + + S ++ + + + + +
Sbjct: 2322 TDLSNSLEKCKEQKGNLE-GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMK 2380
Query: 703 VVNEILPLSNSSFSGKGLVESFASL--QETEEIKSKEAMASSKSPEKSPENLVCSQNSEA 760
I LS + + + A L Q +EIK E + S ++ EN+V + ++
Sbjct: 2381 EQKIISLLSGKE---EAIQVAIAELRQQHDKEIKELENLLS----QEEEENIVLEEENKK 2433
Query: 761 GYINVASLKET 771
L ET
Sbjct: 2434 AVDKTNQLMET 2444
Score = 70.9 bits (172), Expect = 4e-12
Identities = 163/786 (20%), Positives = 321/786 (40%), Gaps = 129/786 (16%)
Query: 2 SQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGE 61
SQ +N+ ESE + ER + ++S ++ +AL + E+ K L+ +V L
Sbjct: 838 SQLQNK--ESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT 895
Query: 62 SESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGG--KTAPS--NLITSENTC 117
E KD + E K+++L++E F+LG KT NL++
Sbjct: 896 IEEKDQQVTEISFSMTE------KMVQLNEE-----KFSLGVEIKTLKEQLNLLSRAEEA 944
Query: 118 KDPESNEPILETEIQSR-KEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQN 176
K + E + E+ S K+ +E+ P G+ ++E+ E +E ++ + Q
Sbjct: 945 KKEQVEE---DNEVSSGLKQNYDEMSPA-GQISKEELQHEF---DLLKKENEQRKRKLQA 997
Query: 177 RDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYN 236
+ +E Q+++ EE+ L++E + L G+ +D E +Y+
Sbjct: 998 ALINRKELLQRVSRLEEELANLKDESK--KEIPLSETERGEVEEDK--------ENKEYS 1047
Query: 237 QQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQK 296
++ + + L+ + E EL++ R DL++ L EE + + K Q
Sbjct: 1048 EKCVTSKCQEIEIYLKQTISEKEVELQHIRK---DLEE--KLAAEEQFQALV--KQMNQT 1100
Query: 297 LLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVA------ 350
L D T L AE Q I++L T + + + LV+E ++
Sbjct: 1101 LQDKTNQIDLLQAEISENQAIIQKLI------TSNTDASDGDSVALVKETVVISPPCTGS 1154
Query: 351 ------DAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEA-TQNEAKVKQQYQEE 403
+ EEKIL L++ EK+QL++K++EA T +A +K+ ++E
Sbjct: 1155 SEHWKPELEEKILALEK----------------EKEQLQKKLQEALTSRKAILKKAQEKE 1198
Query: 404 QQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQ-QQSRIQQQEALLKQLENEKRKYDEH 462
+ R+ L Q D+ +R ++ E Q +Q +IQ +E++ +L + ++ E
Sbjct: 1199 RHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ--ES 1256
Query: 463 VKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNE----------KHHQQKVKL 512
S L E L K ++ L H + + K ++++
Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 513 QKVKYRL-----TNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTL--LLEK 565
+KV+ L T+E+ + + + Q +++I +IE K + + ++L LE
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376
Query: 566 RKLQ----EQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERII 621
+LQ E + E + + + IS + V Y+ + + + ++ +I E +I
Sbjct: 1377 SQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI 1436
Query: 622 RSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEA 681
+++H + KE H ++ L Q E+ E++ + E + E
Sbjct: 1437 KALHTQLEMQAKE-------HDERIKQL-----QVEL----------CEMKQKPEEIGEE 1474
Query: 682 TEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMAS 741
+ + K Q + + I E + E L +G +E T+ + E+ S
Sbjct: 1475 S-RAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL-----TKSLADVESQVS 1528
Query: 742 SKSPEK 747
+++ EK
Sbjct: 1529 AQNKEK 1534
Score = 58.9 bits (141), Expect = 2e-08
Identities = 127/617 (20%), Positives = 242/617 (39%), Gaps = 93/617 (15%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESK-----DHFL 69
K +E E S L ++ + E EE EL+C+ E GE E K H
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEE------ELVCVQKEAAKKVGEIEDKLKKELKHLH 2688
Query: 70 IACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILET 129
+++ E E +V +L+++ ++ L ++T EN K +
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLL--------MVTKEN--KGLTAQIQSFGR 2738
Query: 130 EIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLT 189
+ S + + +L E K+K + S Q +E NR+ E +
Sbjct: 2739 SMSSLQNSRDHANEELDELKRKY-------DASLKELAQLKEQGLLNRERDALLSETAFS 2791
Query: 190 MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLH 249
M E L L +NQ LL S D H SS + YNQ VQ + +
Sbjct: 2792 MNSTEENSL-SHLEKLNQQLL--------SKDEQLLHLSSQLEDSYNQ---VQSFSKAMA 2839
Query: 250 RLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIE-LKHAQQKLLDSTKMCSSLT 308
LQ + NEL E+ + + + S Q +++ LK A L + L
Sbjct: 2840 SLQNERDHLWNEL--EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR---DRLL 2894
Query: 309 AEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHK 368
E K+ QQ+ ++ E+ + +K+Q LQE Q+K+K ++ L Q L H
Sbjct: 2895 KELKNLQQQYLQINQEITE-LHPLKAQ--LQE--YQDKTKAFQIMQEELR-QENLSWQH- 2947
Query: 369 VCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKE 428
E QL + +E ++K+QY + ++ L R++R+ +
Sbjct: 2948 ---------ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQT 2998
Query: 429 NLLEMTCSQQ------------QSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKL 476
L++ +Q Q+ + + E L QL + ++ + Q+L+ S+L
Sbjct: 2999 QPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQL 3058
Query: 477 QQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDE 536
+EK L + + L + ++Y + L N + +K++ + +
Sbjct: 3059 LEEKNTLSIQLCDTSQSLRENQQHYGD---------------LLNHCAVLEKQVQEL--Q 3101
Query: 537 IGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYM 596
G L + A Q++ + E R+ Q+ E +Q + + + ++ ++ ++L
Sbjct: 3102 AGPLNIDV-APGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELR-KLLEE 3159
Query: 597 DKENKQLQENSLRLTQQ 613
+++ + EN+L + ++
Sbjct: 3160 ERDQRVAAENALSVAEE 3176
Score = 46.6 bits (109), Expect = 9e-05
Identities = 105/573 (18%), Positives = 231/573 (40%), Gaps = 70/573 (12%)
Query: 248 LHRLQILCNSAENELRYE--RGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCS 305
L RL L N +EL + QN+ L QE +++ Q+ + +
Sbjct: 2 LSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFN---NTTQEDVQERLAYAE 58
Query: 306 SLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEH 365
L E K I++ ++++ + ++++ + + + K A+ K+ L + +E
Sbjct: 59 QLVVELKDI---IRQKDVQLQQKDEALQEERKAADNKI--KKLKLHAKAKLTSLNKYIEE 113
Query: 366 --AHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRT 423
A + T ++QL + K +T+ E ++++ + Q+K +L + T
Sbjct: 114 MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEEL-----------IST 162
Query: 424 LQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVK---SNQELSEKLSKLQQEK 480
LQ + + Q S ++ ++KQ EK ++ ++ S + + ++ +EK
Sbjct: 163 LQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREK 222
Query: 481 EALREEYLRLL--KLLNVHVRNYNEKHHQQKVKLQKVKYRLTNE--------VELRDKRI 530
+A E +RL +LL + + E QQK+++ + K E V+L + +
Sbjct: 223 DARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL 282
Query: 531 NQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQ 590
E IL ++++ +A + + +T E + L E++ E + K + ++Q
Sbjct: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM---ELEVAERKLSFHNLQ 339
Query: 591 SRVLYMDKENKQLQENSLRLTQQIGFLER------IIRSIHI----RRGENLKEFPVPKW 640
+ ++ ++ +Q + L + LE+ ++ HI + G+ L+
Sbjct: 340 EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK 399
Query: 641 WHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEK---WKHSEQMETTISD 697
KL K ++ + S + +LQ + + + + + +H +T+ D
Sbjct: 400 DQNSKLLQ---DKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD 456
Query: 698 ILE--SEVVNEILPLSNSSFSGKGLVE-------SFASLQETEEIKSKEAMASSKSPEKS 748
+ ++ V E N + K +VE S E EE+K++ SS+
Sbjct: 457 VYNEGTQAVTE----ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLE 512
Query: 749 PENLVCSQNSEAGYINVASL--KETHGIQEQDQ 779
+N + E I++ + K + +E Q
Sbjct: 513 AQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545
Score = 35.8 bits (81), Expect = 0.16
Identities = 87/442 (19%), Positives = 175/442 (39%), Gaps = 74/442 (16%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
+++E++ + E+ S L+ + L + E+L S+L YN+V +
Sbjct: 2777 LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQS--- 2833
Query: 61 ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
F A LQ E L ++ K + T+P+ + + +
Sbjct: 2834 -------FSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSL 2886
Query: 121 ESNEPILETEIQSRKE-------ETEELCP------------KLGERKQKEIPEESVKEG 161
+++ L E+++ ++ E EL P K + Q+E+ +E++
Sbjct: 2887 QNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQ 2946
Query: 162 SFPREGQKEEGSQQ--NRDMKDE------EKEQQLTMKPEEIVRLREELSHINQSLLQSQ 213
+ + E+ S + R MK++ +K+QQL+ I LR S +Q Q
Sbjct: 2947 HELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006
Query: 214 ---SSGDSSDDSGAQH---------PSSGEKLKYNQQGE--VQQLHQNLHRLQI------ 253
S S+ G+Q+ + LK Q E +QQL+ N +L
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLS 3066
Query: 254 --LCNSAENELRYERGQNLDLKQHNSLLQEE-------NIKIKIELKHAQQKLLDSTKMC 304
LC+++++ LR + DL H ++L+++ + I + Q+K K
Sbjct: 3067 IQLCDTSQS-LRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRK-- 3123
Query: 305 SSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNL----QEKLVQEKSKVADAEEKILDLQ 360
S E + QQ E + ++ Q + L +++ V ++ ++ AEE+I L+
Sbjct: 3124 -SDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
Query: 361 RKLEHAHKVCLTDTCISEKQQL 382
+ + + +C +++Q L
Sbjct: 3183 HSEWDSSRTPIIGSCGTQEQAL 3204
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 95.9 bits (237), Expect = 1e-19
Identities = 121/581 (20%), Positives = 257/581 (44%), Gaps = 55/581 (9%)
Query: 18 EREKQLASGLDTAEK---ALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
E +K+LA L AE+ A+ + L+K+K L NEV +L + E + A D
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL---QNEVEDLMIDVERTNAACAALDK 1448
Query: 75 LQRENSELETK-VLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
QR ++ + K + A+L ++ + L +N ++ L+ E ++
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN 1508
Query: 134 RKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPE 193
++E +L ++ E ++ E +K+ + + + ++ + E+ + L ++ E
Sbjct: 1509 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 194 ----------EIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
+I EE+ + ++ ++ S S+ D+ + + +LK +G++ +
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1628
Query: 244 LHQNLHRLQILCNSAENELRYERGQNLDLKQH--NSLLQEENIKIKIELKHAQQKLLDST 301
+ L+ + A R + D + H ++L +E++K ++ + + LL +
Sbjct: 1629 MEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAE 1688
Query: 302 KMCSSLTAEYKHCQQKIKELEL-EVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQ 360
T E +KI E EL + + Q + +QN L+ K K+ E I +Q
Sbjct: 1689 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT---SLINTKKKL---ETDISQIQ 1742
Query: 361 RKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ 420
++E I E + EEK K+A + A + ++ ++EQ L + L +
Sbjct: 1743 GEMEDI---------IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793
Query: 421 VRTLQDK-ENLLEMTCSQQQSRIQQQEALLKQLE----NEKRKYDEHVKSNQELSEKLSK 475
V+ LQ + + ++ + +IQ+ EA +++LE +E+++ E VK ++ K+ +
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKE 1853
Query: 476 LQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFED 535
L + E R+ LRL L++ Q KVK K + E +++ N
Sbjct: 1854 LTYQTEEDRKNILRLQDLVD---------KLQAKVKSYK------RQAEEAEEQSNVNLS 1898
Query: 536 EIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQE 576
+ +QH++E+ + D +Q + L ++ R++ ++I +E
Sbjct: 1899 KFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939
Score = 89.0 bits (219), Expect = 2e-17
Identities = 141/729 (19%), Positives = 302/729 (41%), Gaps = 72/729 (9%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEV-HNLPGESESKDHFLIACD 73
K + +L +D ++ ++L+K KSE+ +++ N+ S++K + C
Sbjct: 1199 KHADSVAELGEQIDNLQRV----KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCR 1254
Query: 74 LLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
L+ + SE++TK ++ +N T + L T + L +++
Sbjct: 1255 ALEDQLSEIKTKE---EEQQRLINDLT----AQRARLQTESGEYSRQLDEKDTLVSQLSR 1307
Query: 134 RKEETEELCPKLGERKQKEIPEESVKEGSFP---------REGQKEEGS-----QQNRDM 179
K+ + +L + ++EI +S + RE +EE Q+
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367
Query: 180 KDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQG 239
+ E Q T + ++ EEL + L Q + ++ +S EK K Q
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427
Query: 240 EVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQ-----HNSL--LQEENIKIKIELKH 292
EV+ L ++ R C + + + R + KQ H L Q+E+ + EL
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 293 AQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADA 352
+ +S +L E K+ QQ+I +L ++ + + I +++++ QEKS++ A
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 353 -----------EEKILDLQRKLEHA-----HKVCLTDTCISEKQQLEEKIKEATQN--EA 394
E KIL +Q +L K+ D I + ++ +I E+ Q+ +A
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDA 1607
Query: 395 KVKQQYQEEQQKRKLLYQNVDELHRQV-----------RTLQDKENLLEMTCSQQQSRIQ 443
+++ + + K+K+ +++E+ Q+ R ++ + +L+ T ++
Sbjct: 1608 EIRSRNDAIRLKKKM-EGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALR 1666
Query: 444 QQEALLKQLENEKRKYD------EHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVH 497
QE L +QL +R+ + E +++ E +E+ K+ +++ E ++LL N
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 498 VRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQ 557
+ N +K ++Q + E +++ + + ++ +++KE+ +
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 558 NDTLLLEKRKLQEQVIEQEQL-IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGF 616
L + LQ ++ E EQL + K I +++RV ++ E + Q+ ++ + +
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRK 1846
Query: 617 LERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKE--IYSTEVFTSNNAELQHE 674
ER ++ + + E+ K + A + K+Q E + V S +QHE
Sbjct: 1847 HERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHE 1906
Query: 675 DESVPEATE 683
E E +
Sbjct: 1907 LEEAEERAD 1915
Score = 76.3 bits (186), Expect = 1e-13
Identities = 129/640 (20%), Positives = 248/640 (38%), Gaps = 110/640 (17%)
Query: 12 EWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEV-HNLPGESESKDHFLI 70
E+S++ + + L S L ++A + EEL++ E I + + H L D
Sbjct: 1290 EYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLRE 1349
Query: 71 ACDLLQRENSELETKVLKLSQEFAQ------------LNHFTLGGKTAPSNLITSEN--- 115
+ Q +EL+ + K + E AQ K L +E
Sbjct: 1350 QYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 116 ----TCKDPESNEPILETEIQSRK---EETEELCPKLGERKQKEIPEESVKEGSFPREGQ 168
C E + L+ E++ E T C L ++KQ+ + + E
Sbjct: 1410 AVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL-DKKQRNFDKILAEWKQKCEETH 1468
Query: 169 KEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPS 228
E + Q + ++ EE + E L N++L Q S G +
Sbjct: 1469 AELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH 1528
Query: 229 SGEKLKYNQQGEVQQLHQNLH--------------RLQILCNSAENELR---YERGQNLD 271
EK+K + E +L L R+Q+ N ++E+ E+ + +D
Sbjct: 1529 ELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1588
Query: 272 LKQHNSLLQEENI-------------------KIKIELKHAQQKLLDSTKMCSSLTAEYK 312
+ N + E++ K++ +L + +L + +M + Y+
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1648
Query: 313 HCQQKIKELEL---EVLKHTQSIKSQ---------------NNLQEKLVQEKSKVADAEE 354
+ Q +K+ +L + L+ + +K Q L+ L Q + AE+
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1708
Query: 355 KILDLQRKLE--HAHKVCLTDT-----------------CISEKQQLEEKIKEATQNEAK 395
++LD +++ H L +T I E + EEK K+A + A
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM 1768
Query: 396 VKQQYQEEQQKRKLLYQNVDELHRQVRTLQDK-ENLLEMTCSQQQSRIQQQEALLKQL-- 452
+ ++ ++EQ L + L + V+ LQ + + ++ + +IQ+ EA +++L
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEG 1828
Query: 453 --ENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKL---LNVHVRNY----NE 503
E+E+++ E VK ++ K+ +L + E R+ LRL L L V++Y E
Sbjct: 1829 EVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1888
Query: 504 KHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHK 543
Q V L K + R+ +E+E ++R + E ++ L+ K
Sbjct: 1889 AEEQSNVNLSKFR-RIQHELEEAEERADIAESQVNKLRVK 1927
Score = 71.6 bits (174), Expect = 3e-12
Identities = 115/545 (21%), Positives = 229/545 (42%), Gaps = 93/545 (17%)
Query: 242 QQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDST 301
++L + + L N + +++ E D ++ L + I+++ ++K ++ D
Sbjct: 875 KELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 934
Query: 302 KMCSSLTA-------EYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEE 354
++ + LTA E ++ I +LEL + K + + N + L +E + + +
Sbjct: 935 EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA 994
Query: 355 KILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE-----EQQKRKL 409
K+ ++ L+ AH+ L D Q E+K+ T+ + K++QQ + EQ+K+
Sbjct: 995 KLTKEKKALQEAHQQTLDDL-----QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIR 1049
Query: 410 LYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ-E 468
+ +L R R L+ L QE+ + +EN+K++ DE +K + E
Sbjct: 1050 M-----DLERAKRKLEGDLKLA-------------QESTM-DIENDKQQLDEKLKKKEFE 1090
Query: 469 LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEK---HHQQKVKLQKVKYRLTNEVEL 525
+S SK++ E +AL + + +K L + E+ + K +K + L+ E+E
Sbjct: 1091 MSGLQSKIEDE-QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 526 RDKRINQFEDEIGILQHKIEKEKAIQ----------DQITAQND-TLLLEKRKLQEQVIE 574
+R+ E+ G +IE K + ++ T Q++ T ++K + V E
Sbjct: 1150 ISERL---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206
Query: 575 QEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKE 634
+ I + + ++ M E L N +++ G LE++ R++ + L E
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE----DQLSE 1262
Query: 635 FPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETT 694
TK++++ T+ A LQ TE ++S Q++
Sbjct: 1263 I---------------KTKEEEQQRLINDLTAQRARLQ---------TESGEYSRQLDE- 1297
Query: 695 ISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVC 754
D L S+ LS + +E Q EEIK+K A+A + + +L+
Sbjct: 1298 -KDTLVSQ-------LSRGKQAFTQQIEEL-KRQLEEEIKAKSALAHALQSSRHDCDLLR 1348
Query: 755 SQNSE 759
Q E
Sbjct: 1349 EQYEE 1353
Score = 60.1 bits (144), Expect = 8e-09
Identities = 103/518 (19%), Positives = 200/518 (38%), Gaps = 113/518 (21%)
Query: 317 KIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCI 376
KIK L LK ++ K N++E+ + K ++A E K
Sbjct: 839 KIKPL----LKSAETEKEMANMKEEFEKTKEELAKTEAK--------------------- 873
Query: 377 SEKQQLEEKIKEATQNEAKVKQQYQEE---------------------QQKRKLLYQNVD 415
+++LEEK+ Q + ++ Q Q E + K K + + +
Sbjct: 874 --RKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAE 931
Query: 416 ELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQE----LSE 471
+ L K+ LE CS+ + I E L ++E EK + VK+ E L E
Sbjct: 932 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 991
Query: 472 KLSKLQQEKEALREEYLRLLKLLNVHVRNYN--------------------EKHHQQKVK 511
++KL +EK+AL+E + + L L N E+ + ++
Sbjct: 992 TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD 1051
Query: 512 LQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQ 571
L++ K +L +++L + E++ L K++K++ E LQ +
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE--------------FEMSGLQSK 1097
Query: 572 VIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGEN 631
+ +++ L + I +Q+R+ +++E + + + + +Q L R + I E
Sbjct: 1098 IEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI----SER 1153
Query: 632 LKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQM 691
L+E A + KK++ + A LQHE AT + KH++ +
Sbjct: 1154 LEEA------GGATSAQIEMNKKREAEFQKMRRDLEEATLQHE---ATAATLRKKHADSV 1204
Query: 692 ETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSK-----------EAMA 740
I + V + L S K ++ AS ET K+K + ++
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSEM--KMEIDDLASNMETVS-KAKGNLEKMCRALEDQLS 1261
Query: 741 SSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQD 778
K+ E+ + L+ ++ + S + + + E+D
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD 1299
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 95.5 bits (236), Expect = 2e-19
Identities = 125/576 (21%), Positives = 253/576 (43%), Gaps = 65/576 (11%)
Query: 18 EREKQLASGLDTAEK---ALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
E +K+LA L AE+ A+ + L+K+K L NEV +L + E + A D
Sbjct: 1391 EAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL---QNEVEDLMLDVERSNAACAALDK 1447
Query: 75 LQRE-NSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
QR + L K + A+L ++ + L +N ++ L E ++
Sbjct: 1448 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKN 1507
Query: 134 RKEETEELCPKLGE---------RKQKEIPEESVK--------EGSFPREGQKEEGSQQN 176
++E +L ++ E + +K++ +E + E S E K Q
Sbjct: 1508 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567
Query: 177 RDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYN 236
+ E ++++ K EEI +L+ + + +++ S+ D+ + + ++K
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETM-------QSTLDAEIRSRNDALRVKKK 1620
Query: 237 QQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQH--NSLLQEENIKIKIELKHAQ 294
+G++ ++ L+ L + R +G + + H ++L +E++K ++ + +
Sbjct: 1621 MEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERR 1680
Query: 295 QKLLDSTKMCSSLTAEYKHCQQKIKELEL-EVLKHTQSIKSQNNLQEKLVQEKSKVADAE 353
LL + T E +KI E EL + + Q + +QN L+ K K+ E
Sbjct: 1681 ANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNT---SLINTKKKL---E 1734
Query: 354 EKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQN 413
+ LQ ++E I E + EEK K+A + A + ++ ++EQ L +
Sbjct: 1735 NDVSQLQSEVEEV---------IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1785
Query: 414 VDELHRQVRTLQDK-ENLLEMTCSQQQSRIQQQEALLKQLE----NEKRKYDEHVKSNQE 468
L + V+ LQ + + ++ + +IQ+ EA +++LE NE+++ E VK ++
Sbjct: 1786 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRK 1845
Query: 469 LSEKLSKLQQEKEALREEYLRLLKL---LNVHVRNY----NEKHHQQKVKLQKVKYRLTN 521
++ +L + E R+ LRL L L V++Y E Q L K + +L +
Sbjct: 1846 HERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR-KLQH 1904
Query: 522 EVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQ 557
E+E ++R + E ++ L+ K + + +I+A+
Sbjct: 1905 ELEEAEERADIAESQVNKLR---VKSREVHTKISAE 1937
Score = 95.1 bits (235), Expect = 2e-19
Identities = 145/732 (19%), Positives = 302/732 (41%), Gaps = 90/732 (12%)
Query: 13 WSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIAC 72
W K + K L +T EK + EE QK+K EL +SE+K
Sbjct: 832 WMKLFFKIKPLLKSAET-EKEMATMKEEFQKTKDEL-----------AKSEAK------- 872
Query: 73 DLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILET--- 129
ELE K++ L +E N L ++ +L +E C+ N+ LE
Sbjct: 873 ------RKELEEKMVTLLKE---KNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIK 923
Query: 130 EIQSRKEETEELCPKLGERKQK---EIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQ 186
E+ R EE EE+ +L +K+K E E K E + + K + +
Sbjct: 924 EVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 983
Query: 187 QLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKY---NQQGEVQQ 243
++ E I +L +E + ++ Q+ + +D + KL+ + +G ++Q
Sbjct: 984 EMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ 1043
Query: 244 LHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKM 303
+ L+ E +L+ + +D++ L E+ K + E+ + K+ D +
Sbjct: 1044 EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAV 1103
Query: 304 CSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKL 363
L Q+KIKEL+ + + + I+++ + K +++S D ++ ++ +L
Sbjct: 1104 EIQL-------QKKIKELQARIEELGEEIEAERASRAKAEKQRS---DLSRELEEISERL 1153
Query: 364 EHA-----HKVCLTDTCISEKQQLEEKIKEAT-QNEAKVKQQYQEEQQKRKLLYQNVDEL 417
E A +V L +E Q+L ++EAT Q+EA V ++ L + +D L
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213
Query: 418 HRQVRTLQDKENLLEMTCSQQQSRIQ-------QQEALLKQLENE----KRKYDEHVKSN 466
R + L+ +++ L+M S + E + + LE++ K K +E +
Sbjct: 1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI 1273
Query: 467 QELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELR 526
+L+ + ++LQ E EY R L + V + +++++K++L E + +
Sbjct: 1274 NDLTAQRARLQTE----AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAK 1329
Query: 527 DKRINQFED---EIGILQHKIEKEK----AIQDQITAQNDTLLLEKRKLQEQVIEQEQLI 579
+ + + + +L+ + E+E+ +Q ++ N + + K + I++ + +
Sbjct: 1330 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1389
Query: 580 HSNKWT-----------ISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRR 628
K + ++ ++ ++K ++LQ L + ++ ++
Sbjct: 1390 EEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449
Query: 629 GENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHS 688
K K + A L ++K+ STE+F N +ES+ + + +
Sbjct: 1450 RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNV----YEESLDQLETLRREN 1505
Query: 689 EQMETTISDILE 700
+ ++ ISD+ E
Sbjct: 1506 KNLQQEISDLTE 1517
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/672 (19%), Positives = 277/672 (41%), Gaps = 60/672 (8%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVH-NLPGESESKDHFLIACD 73
K + +L +D ++ ++L+K KSEL +++ N S++K + C
Sbjct: 1198 KHADSMAELGEQIDNLQRV----KQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253
Query: 74 LLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
L+ + SEL+TK ++ +N T + + ++ L Q+
Sbjct: 1254 SLEDQVSELKTKE---EEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQA 1310
Query: 134 RKEETEELCPKLGERKQKEIP-----EESVKEGSFPREGQKEEGS-----QQNRDMKDEE 183
++ EEL +L E + + + S + RE +EE Q+ + E
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1370
Query: 184 KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
Q T + ++ EEL + L Q + ++ +S EK K Q EV+
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430
Query: 244 LHQNLHRLQILCNSAENELRY------ERGQNLDLKQHN-SLLQEENIKIKIELKHAQQK 296
L ++ R C + + + R E Q + Q Q+E+ + EL +
Sbjct: 1431 LMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNV 1490
Query: 297 LLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADA---- 352
+S +L E K+ QQ+I +L ++ + + I +++++ QEK ++ A
Sbjct: 1491 YEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEA 1550
Query: 353 -------EEKILDLQRKLEHA-----HKVCLTDTCISEKQQLEEKIKEATQ--------- 391
E KIL +Q +L K+ D I + ++ ++ E Q
Sbjct: 1551 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS 1610
Query: 392 -NEA-KVKQQYQEEQQKRKLLYQNVDELHRQ-VRTLQDKENLLEMTCSQQQSRIQQQEAL 448
N+A +VK++ + + + ++ + + L + +R ++ + +L+ T ++ QE L
Sbjct: 1611 RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDL 1670
Query: 449 LKQLENEKRKYD------EHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYN 502
+QL +R+ + E + + E +E+ K+ +++ E ++LL N + N
Sbjct: 1671 KEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1730
Query: 503 EKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLL 562
+K +LQ + E +++ + + ++ +++KE+ + L
Sbjct: 1731 KKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1790
Query: 563 LEKRKLQEQVIEQEQL-IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERII 621
+ LQ ++ E EQL + K I +++RV ++ E + Q+ + + + ER +
Sbjct: 1791 QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRV 1850
Query: 622 RSIHIRRGENLK 633
+ + + E+ K
Sbjct: 1851 KELTYQTEEDRK 1862
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 95.5 bits (236), Expect = 2e-19
Identities = 120/580 (20%), Positives = 256/580 (44%), Gaps = 53/580 (9%)
Query: 18 EREKQLASGLDTAEK---ALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
E +K+LA L AE+ A+ + L+K+K L NEV +L + E + IA D
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL---QNEVEDLMIDVERSNAACIALDK 1448
Query: 75 LQRE-NSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
QR + L K + A+L ++ + L +N ++ + L+ E ++
Sbjct: 1449 KQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKN 1508
Query: 134 RKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPE 193
++E +L ++ E + E VK+ + + + ++ + E+ + L ++ E
Sbjct: 1509 LQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLE 1568
Query: 194 ----------EIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
+I EEL + ++ L+ S S+ D+ + + ++K +G++ +
Sbjct: 1569 LNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNE 1628
Query: 244 LHQNLHRLQILCNSAENELRYERGQNLDLKQH--NSLLQEENIKIKIELKHAQQKLLDST 301
+ L+ A LR +G D + H +++ ++++K ++ + + L+ +
Sbjct: 1629 MEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAE 1688
Query: 302 KMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQR 361
L A + ++ K E E+L ++ ++ + L+ K K+ E I +Q
Sbjct: 1689 --VEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKL---ETDISQIQG 1743
Query: 362 KLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQV 421
++E + E + EEK K+A + A + ++ ++EQ L + + + V
Sbjct: 1744 EMEDI---------VQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV 1794
Query: 422 RTLQDK-ENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEH----VKSNQELSEKLSKL 476
+ LQ + + ++ + +IQ+ EA +++LE+E +H VK ++ ++ +L
Sbjct: 1795 KDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKEL 1854
Query: 477 QQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDE 536
+ E R+ LRL L++ Q KVK K + E +++ N +
Sbjct: 1855 TYQTEEDRKNILRLQDLVD---------KLQTKVKAYK------RQAEEAEEQSNVNLAK 1899
Query: 537 IGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQE 576
LQH++E+ K D +Q + L ++ R++ +VI +E
Sbjct: 1900 FRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 91.3 bits (225), Expect = 3e-18
Identities = 130/684 (19%), Positives = 291/684 (42%), Gaps = 56/684 (8%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEV-HNLPGE 61
+E E+ + R++ + L +L+ ++L+K KSEL N++ N+
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETV 1242
Query: 62 SESKDHFLIACDLLQRENSELETK-------VLKLSQEFAQLNHFTLGGKTAPSNLITSE 114
S++K +F C L+ + SE++TK + +LS + A+L+ T G+ + L +
Sbjct: 1243 SKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLH--TESGEFS-RQLDEKD 1299
Query: 115 NTCKDPESNEPILETEIQSRKEETEELCPK---LGERKQKEIPEESVKEGSFPREGQKEE 171
+ +I+ K + EE L Q + + + E + +
Sbjct: 1300 AMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359
Query: 172 GSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGE 231
Q+ + E Q T + ++ EEL + L Q + ++ +S E
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419
Query: 232 KLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNS-------LLQEENI 284
K K Q EV+ L ++ R C + + + R + KQ Q+E+
Sbjct: 1420 KTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESR 1479
Query: 285 KIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQ 344
+ EL + +S +L E K+ QQ+I +L ++ + + I ++++L
Sbjct: 1480 SLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDH 1539
Query: 345 EKSKVADA-----------EEKILDLQRKLEHA-----HKVCLTDTCISEKQQLEEKIKE 388
EKS++ + E KIL +Q +L K+ D + + ++ ++ E
Sbjct: 1540 EKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVE 1599
Query: 389 ATQN--EAKVKQQYQEEQQKRKL------LYQNVDELHRQ----VRTLQDKENLLEMTCS 436
+ Q+ +A+++ + + K+K+ + ++ +RQ +R L++ + +L+ T
Sbjct: 1600 SMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQL 1659
Query: 437 QQQSRIQQQEALLKQLENEKRKYD------EHVKSNQELSEKLSKLQQEKEALREEYLRL 490
I+ Q+ L +QL +R+ + E ++++ E +E+ K+ +++ E ++L
Sbjct: 1660 HLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQL 1719
Query: 491 LKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAI 550
L N + N +K ++Q + E +++ + + ++ +++KE+
Sbjct: 1720 LHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 551 QDQITAQNDTLLLEKRKLQEQVIEQEQL-IHSNKWTISSIQSRVLYMDKENKQLQENSLR 609
+ + + LQ ++ E EQL + K I +++RV ++ E + Q++++
Sbjct: 1780 SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVE 1839
Query: 610 LTQQIGFLERIIRSIHIRRGENLK 633
+ + ER ++ + + E+ K
Sbjct: 1840 AVKGLRKHERRVKELTYQTEEDRK 1863
Score = 69.7 bits (169), Expect = 1e-11
Identities = 82/339 (24%), Positives = 151/339 (44%), Gaps = 60/339 (17%)
Query: 285 KIKIELKHAQ--QKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKL 342
KIK LK A+ +++ + + E + K KELE +++ Q +N+LQ ++
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQE---KNDLQLQV 895
Query: 343 VQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE 402
E +ADAEE+ D I K QLE KIKE T+
Sbjct: 896 QAEADALADAEERC----------------DQLIKTKIQLEAKIKEVTERA--------- 930
Query: 403 EQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEH 462
++ +E++ + L K+ LE CS+ + I E L ++E EK +
Sbjct: 931 ---------EDEEEINAE---LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978
Query: 463 VKSNQE----LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYR 518
VK+ E L E ++KL +EK+AL+E + + L L + N L K K +
Sbjct: 979 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVN--------TLTKAKTK 1030
Query: 519 LTNEVELRDKRINQFED---EIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ 575
L +V+ + + Q + ++ + K+E + + + T + +K++L E++ ++
Sbjct: 1031 LEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEN---DKQQLNEKLKKK 1087
Query: 576 EQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQI 614
E + + + I Q+ + + K+ K+LQ L ++I
Sbjct: 1088 EFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI 1126
Score = 67.4 bits (163), Expect = 5e-11
Identities = 115/589 (19%), Positives = 235/589 (39%), Gaps = 141/589 (23%)
Query: 13 WSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIAC 72
W K + K L +T EK + EE +K+K EL ++E+K
Sbjct: 833 WMKLYFKIKPLLKSAET-EKEMANMKEEFEKTKEEL-----------AKTEAK------- 873
Query: 73 DLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILET--- 129
ELE K++ L QE N L + L +E C + LE
Sbjct: 874 ------RKELEEKMVTLMQE---KNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIK 924
Query: 130 EIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKD-------E 182
E+ R E+ EE+ +L +K+K ++E S+ +D+ D
Sbjct: 925 EVTERAEDEEEINAELTAKKRK----------------LEDECSELKKDIDDLELTLAKV 968
Query: 183 EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
EKE+ T ++ L EE++ +++++ + + ++ H + + L+ ++ +V
Sbjct: 969 EKEKHAT--ENKVKNLTEEMAGLDETIAKLTKEKKALQEA---HQQTLDDLQM-EEDKVN 1022
Query: 243 QLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTK 302
L + +L+ + E L E+ +DL++ K++ +LK AQ+ +D+
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKR-------KLEGDLKLAQESTMDTEN 1075
Query: 303 MCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRK 362
+ + +K+K+ E E+ +NLQ K+ E++
Sbjct: 1076 -------DKQQLNEKLKKKEFEM----------SNLQGKIEDEQALAI------------ 1106
Query: 363 LEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVR 422
QL++KIKE +++++ + E+ R + +L R++
Sbjct: 1107 ------------------QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148
Query: 423 TLQDKENLLEMTCSQQQSRIQQQEA----LLKQLENEKRKYD--------EHVKSNQELS 470
+ ++ S Q +++EA + + LE +++ +H S EL
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELG 1208
Query: 471 EKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRI 530
E++ LQ+ K+ L +E L +N N + V K + +K
Sbjct: 1209 EQIDSLQRVKQKLEKEKSELKMEINDLASN------METVSKAKANF---------EKMC 1253
Query: 531 NQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLI 579
ED++ ++ K E+++ + ++++AQ L E + Q+ E++ ++
Sbjct: 1254 RTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMV 1302
Score = 39.3 bits (90), Expect = 0.014
Identities = 64/307 (20%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 448 LLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQ 507
LLK E EK + + ++ E+L+K + +++ L E+ + L++ EK+
Sbjct: 843 LLKSAETEKEMANMK-EEFEKTKEELAKTEAKRKELEEKMVTLMQ----------EKNDL 891
Query: 508 QKVKLQKVKYRLTNEVELRDKRIN---QFEDEIGILQHKIEKEKAIQDQITAQNDTLLLE 564
Q +++Q L + E D+ I Q E +I + + E E+ I ++TA+
Sbjct: 892 Q-LQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK------- 943
Query: 565 KRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSI 624
KRKL+++ E ++ I + T++ ++ + + K L E L + I L + +++
Sbjct: 944 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1003
Query: 625 HIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEK 684
+ L + + + + + TK ++++ E +L + E E
Sbjct: 1004 QEAHQQTLDDLQMEE--DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG 1061
Query: 685 WKHSEQMETTISDILESEVVNEILPLSNSSFSG-KGLVESFASLQETEEIKSKEAMASSK 743
Q E+T+ + + +NE L S +G +E +L + K KE A +
Sbjct: 1062 DLKLAQ-ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIE 1120
Query: 744 SPEKSPE 750
E+ E
Sbjct: 1121 ELEEEIE 1127
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 95.1 bits (235), Expect = 2e-19
Identities = 154/763 (20%), Positives = 320/763 (41%), Gaps = 109/763 (14%)
Query: 4 EKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESE 63
E + E + + + ++L L+ + L +EL++ + EL L E NL ++
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 64 SKDHFLIACDLLQREN---SELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
S + D L+ + +LE++V + + + + K L
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY----KARVEEL---------K 350
Query: 121 ESNEPILETE--IQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRD 178
E N+ +LET+ ++ + E T KL E +++ + +K E +++ ++ +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENL---QLKAKLHDMEMERDMDRKKIEE 407
Query: 179 MKDEEKEQQLTMKP--EEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYN 236
+ +E ++ K +E + L EL I+++ S++ S +S LK
Sbjct: 408 LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE-VNELTSSRLLKLE 466
Query: 237 QQGEVQQLHQNLHRLQILCNSAENE----LRYERGQNLDLKQHNSLLQEENIKIKIELKH 292
+ Q L + + L+ +S E L+ E+ +N L + +L+ E ++ K L++
Sbjct: 467 MEN--QSLTKTVEELRTTVDSVEGNASKILKMEK-ENQRLSKKVEILENEIVQEKQSLQN 523
Query: 293 AQQKLLDSTKMCSSLTAEYK----HCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSK 348
Q D K + L + + +++IK LE E Q++ S ++++S+
Sbjct: 524 CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS--------LRQRSQ 575
Query: 349 VADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRK 408
++ AE ++ D++++ + H+ I E KI+ + K + Y+E+ ++ +
Sbjct: 576 IS-AEARVKDIEKENKILHE------SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628
Query: 409 LLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQE 468
L + L ++ LQ K L++TC + ++ Q+ +LE E RK + + S +
Sbjct: 629 ELENELHHLEKENELLQKKITNLKITCEKIEALEQENS----ELERENRKLKKTLDSFKN 684
Query: 469 LSEKLSKLQQEKEALREEYLRL-----------LKLLNVHVRNYNEKHHQQKVK----LQ 513
L+ +L L++E L EE L L +K+ + + N + ++++K L
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
Query: 514 KVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVI 573
K ++ T +E+ + + + E LQ +E Q+ ++ L +E + LQ+ +
Sbjct: 745 KASFKKTERLEVSYQGL---DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Query: 574 EQ-------EQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHI 626
E EQL NK S++ ++K+ KQL++ + RL QQ + + ++
Sbjct: 802 ELKISSKRLEQLEKENK----SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857
Query: 627 RRGENLKEFPVPK---WWHRGKLASLPPTKKQK-----------------------EIYS 660
+ G KE ++ L +K+ E
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Query: 661 TEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEV 703
T+ ++ +L HE E + E+ H EQ +LES++
Sbjct: 918 TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL 960
Score = 92.0 bits (227), Expect = 2e-18
Identities = 134/651 (20%), Positives = 271/651 (41%), Gaps = 107/651 (16%)
Query: 5 KNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESES 64
+N+ + + + K+L L+ K+L+ E+ +L+K K +L E L ++E
Sbjct: 792 ENQTLQKNLEELKISSKRLEQ-LEKENKSLEQETSQLEKDKKQL---EKENKRLRQQAEI 847
Query: 65 KDHFL----IACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNL---ITSENTC 117
KD L + L++EN L ++ + +L K I + T
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 118 KDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNR 177
++ +E + ++ + E+ K+G K++ + +E + + K E + +
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967
Query: 178 DMKDEEKEQQLTMKPEEIV----RLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKL 233
EEK L + EE +LR+EL + ++ + D + P SGE
Sbjct: 968 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1027
Query: 234 KYNQ--------------------------QGEVQQLHQNLHRLQILCNSAENELRYERG 267
K+ + Q E Q L L +L+ N+ + ++ +
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1087
Query: 268 QNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLK 327
Q + L++ N+ LQ +N K+++E +ST S + ++ Q I++ LE
Sbjct: 1088 QTVSLQEQNTTLQTQNAKLQVE---------NSTLNSQSTSLMNQNAQLLIQQSSLE--- 1135
Query: 328 HTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIK 387
N E +++E+ + + ++ KLE H E+Q E +
Sbjct: 1136 ---------NENESVIKEREDLKSLYDSLIKDHEKLELLH----------ERQASE--YE 1174
Query: 388 EATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEA 447
+K ++ + + + L ++L +Q L+D E +L +++Q++
Sbjct: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML---------KVEQEKM 1225
Query: 448 LLKQLENEK--RKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKH 505
LL+ +E +Y + N L+ S+L +E E L+ ++ L LLN N K
Sbjct: 1226 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN------NSKL 1279
Query: 506 HQQKVKLQKVKYRLT-NEVELRDKRINQFEDEIGILQHKIEKE-KAIQDQITAQNDTLLL 563
Q +++ + K + ++++ ++N + + L+ +E+E + + DQI TL+L
Sbjct: 1280 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI----QTLML 1335
Query: 564 EKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQI 614
+ R L EQ +E + L H ++ R Y+DK N +L+ +L ++I
Sbjct: 1336 QNRTLLEQNMESKDLFH--------VEQR-QYIDKLN-ELRRQKEKLEEKI 1376
Score = 78.2 bits (191), Expect = 3e-14
Identities = 150/770 (19%), Positives = 323/770 (41%), Gaps = 126/770 (16%)
Query: 1 MSQEKNEMFESEWSKEREREK--------QLASGLDTAEKALKVESEELQKSKSELICLY 52
+S+ K + + E+ K R E + + L+ + + S++L + + E + L
Sbjct: 329 VSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 53 NEVHNLPGESESKDHFLIACDLLQRENSELET-------KVLKLSQEFAQLNHFTLGGKT 105
++H++ E +D + L EN LE + L L E Q++ T
Sbjct: 389 AKLHDMEME---RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR-TSELSE 444
Query: 106 APS-------NLITSENTCKDPESNEPILET--EIQSRKEETEELCPKLGERKQKEIPEE 156
AP N +TS K N+ + +T E+++ + E K+ + +KE
Sbjct: 445 APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKENQRL 503
Query: 157 SVKEGSFPREGQKEEGSQQN-----RDMKDEEKEQQLTMKP------EEIVRLREELSHI 205
S K E +E+ S QN +D+ E+ + + T++ +I L +E H+
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 206 NQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRY- 264
NQ++ + S ++ + K+ + +++ L +++ + EL +
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHES---IKETSSKLSKIEFEKRQIKKELEHY 620
Query: 265 ----ERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKE 320
ER + L+ + H+ L++EN + Q+K+ + C + A +Q+ E
Sbjct: 621 KEKGERAEELENELHH--LEKENELL-------QKKITNLKITCEKIEA----LEQENSE 667
Query: 321 LELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCI---- 376
LE E K +++ S NL +L + + + +E+ L+L+R +E + +
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 377 ----SEKQQLE---EKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKEN 429
SEK+QL+ E +K + + +++ YQ + + L + ++ +++++ L+ +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 430 LLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYL- 488
LEM Q +++ + K+LE +++ + +L + +L++E + LR++
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847
Query: 489 --RLLKLLNVHVRNYN-----------------------EKHHQQKVKLQKVKYR----L 519
L+ NV + N EK +++ VK + + L
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 520 TNEVELRDKRINQFEDEIGILQHKIE-----KEKAIQDQITAQNDTLLLEKRKLQEQVIE 574
++ + Q +++ L H++E KE+ + D+ + + LLE + E ++
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESK--LESTLK 965
Query: 575 QEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFL------ERIIRSIHIRR 628
+ I K I+++++R+ N+QL++ + + L ER+++S
Sbjct: 966 KSLEIKEEK--IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1023
Query: 629 GENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESV 678
GE+ KW + + K + + E NNA LQ E +++
Sbjct: 1024 GED------NKWERESQETTRELLKVKDRLIEVE---RNNATLQAEKQAL 1064
Score = 63.5 bits (153), Expect = 7e-10
Identities = 145/719 (20%), Positives = 297/719 (41%), Gaps = 93/719 (12%)
Query: 114 ENTCKDPESNEPILETE-------IQSRKEETEELCPKLGERKQKEIPEESVKEGSFP-- 164
E T E EP+L+ I R E +E + ER + P
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCG 236
Query: 165 REGQKEEGSQQNRDM-------KDEEKEQQLTMKPEEIVRLREELSHINQSL--LQSQSS 215
G K S+Q+ + K Q+L K E+++ ++EL + L LQ ++
Sbjct: 237 SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENM 296
Query: 216 GDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQH 275
SD A+ + V +L + R + +++ + + + +LK+
Sbjct: 297 NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK----ERLHDIEFYKARVEELKED 352
Query: 276 NSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQ 335
N +L E ++ +L+ + + S K+ E ++ Q K K ++E+ + K +
Sbjct: 353 NQVLLETKTMLEDQLEGTRAR---SDKLHE---LEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 336 NNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAK 395
++E + E ++ +E L L +LE + SE + +K NE
Sbjct: 407 ELMEENMTLEMAQKQSMDES-LHLGWELEQISRT-------SELSEAPQKSLGHEVNELT 458
Query: 396 VKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENE 455
+ + E + + L + V+EL V +++ + + + Q ++ E L ++ E
Sbjct: 459 SSRLLKLEMENQSLT-KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 456 KRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLL---NVHVRN------------ 500
K+ +++L ++ ++L++ E LRE R +K+L N H+
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 501 --------------YNEKHHQQKVKLQKVKY---RLTNEVE---LRDKRINQFEDEIGIL 540
+E + KL K+++ ++ E+E + +R + E+E+
Sbjct: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL--- 634
Query: 541 QHKIEKE-KAIQDQITAQNDTLLLEK-RKLQEQVIEQEQLIHSNKWTISSIQS---RVLY 595
H +EKE + +Q +IT N + EK L+++ E E+ K T+ S ++ ++
Sbjct: 635 -HHLEKENELLQKKIT--NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES 691
Query: 596 MDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQ 655
++KEN QL E +L L + + L+ + + EN KE K + L L + K+
Sbjct: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN-KELESEKEQLKKGLELLKASFKK 750
Query: 656 KEIYSTEVFTSNNAELQHEDESVPEATEKW-KHSEQMETTISDI-LESEVVNEIL-PLSN 712
TE + L E++ + + E K +Q+E+ + D+ +E++ + + L L
Sbjct: 751 -----TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKI 805
Query: 713 SSFSGKGLVESFASL-QETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKE 770
SS + L + SL QET +++ + ++ + + E + + +L++
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
Score = 60.8 bits (146), Expect = 5e-09
Identities = 100/455 (21%), Positives = 192/455 (42%), Gaps = 65/455 (14%)
Query: 310 EYKHCQQKIKELE-LEVLKHTQS-----IKSQNNLQEKLVQEKSKVADAEEKILDLQRKL 363
E H Q+ + +L+ +EV +Q +K+ ++L+ E+ + E I++L +
Sbjct: 162 EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERD---EHSETIIELSEER 218
Query: 364 EHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRT 423
+ H L S + + T++ + + + + K + L Q ++E Q+
Sbjct: 219 DGLH--FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL-- 274
Query: 424 LQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEAL 483
+ C Q+ ++Q E LK+L+ E +S + ++L +AL
Sbjct: 275 ---------LDCKQE---LEQMEIELKRLQQENMNLLSDARSARMYRDEL-------DAL 315
Query: 484 REEYLRLLKLLNVHVRNYNEKHHQ---QKVKLQKVKYRLTNEVELRDKRINQFEDEIGIL 540
RE+ +R+ KL + V Y E+ H K +++++K N+V L K + L
Sbjct: 316 REKAVRVDKLES-EVSRYKERLHDIEFYKARVEELKE--DNQVLLETKTM---------L 363
Query: 541 QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKEN 600
+ ++E +A D++ L K KL + +E++ ++ I + + ++
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM----DRKKIEELMEENMTLEMAQ 419
Query: 601 KQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYS 660
KQ + SL L + LE+I R+ L E P H ++ L ++ K
Sbjct: 420 KQSMDESLHLGWE---LEQISRT------SELSEAPQKSLGH--EVNELTSSRLLKLEME 468
Query: 661 TEVFTSNNAELQHEDESVPEATEKWKHSEQMETTIS---DILESEVVNEILPLSNSSFSG 717
+ T EL+ +SV K E+ +S +ILE+E+V E L N
Sbjct: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 718 KGLVESFASLQETEEIKSKEAMASSKSPEKSPENL 752
K L++ A L++T E + + K E+ E+L
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 95.1 bits (235), Expect = 2e-19
Identities = 120/581 (20%), Positives = 261/581 (44%), Gaps = 55/581 (9%)
Query: 18 EREKQLASGLDTAEK---ALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
E +K+LA L AE+ A+ + L+K+K L NEV +L + E + A D
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL---QNEVEDLMLDVERTNAACAALDK 1450
Query: 75 LQRENSELETK-VLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
QR ++ + K + A+L ++ + L +N ++ L+ E ++
Sbjct: 1451 KQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKN 1510
Query: 134 RKEETEELCPKLGE---------RKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEK 184
++E +L ++ E + +K++ +E + + E + ++ + ++ + +
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 185 EQQLTMKPE-EIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
Q+ + + +I EE+ + ++ ++ S S+ D+ + + +LK +G++ +
Sbjct: 1571 LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630
Query: 244 LHQNLHRLQILCNSAENELRYERGQNLDLKQH--NSLLQEENIKIKIELKHAQQKLLDST 301
+ L+ + A R +G D + H ++L +E++K ++ + + LL +
Sbjct: 1631 MEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAE 1690
Query: 302 KMCSSLTAEYKHCQQKIKELEL-EVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQ 360
T E +KI E EL + + Q + +QN L+ K K+ E I +Q
Sbjct: 1691 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT---SLINTKKKL---ETDISQMQ 1744
Query: 361 RKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ 420
++E + E + EEK K+A + A + ++ ++EQ L + + +
Sbjct: 1745 GEMEDI---------LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 421 VRTLQDK-ENLLEMTCSQQQSRIQQQEALLKQLE----NEKRKYDEHVKSNQELSEKLSK 475
V+ LQ + + ++ + +IQ+ EA +++LE +E+++ E VK ++ ++ +
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 476 LQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFED 535
L + E R+ LRL L++ Q KVK K + E +++ N
Sbjct: 1856 LTYQTEEDRKNILRLQDLVD---------KLQAKVKSYK------RQAEEAEEQSNTNLA 1900
Query: 536 EIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQE 576
+ LQH++E+ + D +Q + L ++ R++ +VI +E
Sbjct: 1901 KFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 82.4 bits (202), Expect = 1e-15
Identities = 140/740 (18%), Positives = 301/740 (40%), Gaps = 68/740 (9%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEV-HNLPGESESKDHFLIACD 73
K + +L +D ++ ++L+K KSE+ +++ N+ S++K + C
Sbjct: 1201 KHADSVAELGEQIDNLQRV----KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 74 LLQRENSELETKVLK----LSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILET 129
L+ + SEL++K + ++ AQ L E +
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 130 EIQSRKEETEELCPK---LGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQ 186
+I+ K + EE L Q + + + E + + Q+ + E Q
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 187 QLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQ 246
T + ++ EEL + L Q + + ++ +S EK K Q EV+ L
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 247 NLHRLQILCNSAENELRYERGQNLDLKQ-----HNSL--LQEENIKIKIELKHAQQKLLD 299
++ R C + + + R + KQ H L Q+E + EL + +
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 300 STKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADA------- 352
S +L E K+ QQ+I +L ++ + + I +++++ QEK ++ A
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 353 ----EEKILDLQRKLEHA-----HKVCLTDTCISEKQQLEEKIKEATQN--EAKVKQQYQ 401
E KIL +Q +L K+ D I + ++ +I E+ Q+ +A+++ +
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 402 EEQQKRKLLYQNVDELHRQV-----------RTLQDKENLLEMTCSQQQSRIQQQEALLK 450
+ K+K+ +++E+ Q+ R ++ + +L+ T ++ QE L +
Sbjct: 1617 AIRLKKKM-EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675
Query: 451 QLENEKRKYD------EHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEK 504
QL +R+ + E +++ E +E+ K+ +++ E ++LL N + N +K
Sbjct: 1676 QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 505 HHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLE 564
++Q + E +++ + + ++ +++KE+ + +
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 565 KRKLQEQVIEQEQL-IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRS 623
+ LQ ++ E EQL + K I +++RV ++ E + Q+ + + + ER ++
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 624 IHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATE 683
+ + E+ K + A + K+Q E + E +N A+ + + EA E
Sbjct: 1856 LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEEAEE 1914
Query: 684 KWKHSEQMETTISDILESEV 703
+ +DI ES+V
Sbjct: 1915 R-----------ADIAESQV 1923
Score = 77.0 bits (188), Expect = 6e-14
Identities = 117/531 (22%), Positives = 217/531 (40%), Gaps = 107/531 (20%)
Query: 285 KIKIELKHAQ--QKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKL 342
KIK LK A+ +++ + + E + K KELE +++ +K +N+LQ ++
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVT---LLKEKNDLQLQV 897
Query: 343 VQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE 402
E +ADAEE+ D I K QLE KIKE T+
Sbjct: 898 QAEAEGLADAEER----------------CDQLIKTKIQLEAKIKEVTERA--------- 932
Query: 403 EQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEH 462
++ +E++ + L K+ LE CS+ + I E L ++E EK +
Sbjct: 933 ---------EDEEEINAE---LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 463 VKSNQE----LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYN---------------- 502
VK+ E L E ++KL +EK+AL+E + + L L N
Sbjct: 981 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL 1040
Query: 503 ----EKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQN 558
E+ + ++ L++ K +L +++L + I E+E L K++K++
Sbjct: 1041 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE---------- 1090
Query: 559 DTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLE 618
E LQ ++ +++ L + I +Q+R+ +++E + + + + +Q L
Sbjct: 1091 ----FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 619 RIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESV 678
R + I E L+E A + KK++ + A LQHE
Sbjct: 1147 RELEEI----SERLEEA------GGATSAQIEMNKKREAEFQKMRRDLEEATLQHE---A 1193
Query: 679 PEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSK-- 736
AT + KH++ + I + V + L S K ++ AS ET K+K
Sbjct: 1194 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM--KMEIDDLASNVETVS-KAKGN 1250
Query: 737 ---------EAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQD 778
+ ++ KS E+ + L+ ++ G + S + + + E++
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301
Score = 73.6 bits (179), Expect = 7e-13
Identities = 116/565 (20%), Positives = 234/565 (41%), Gaps = 81/565 (14%)
Query: 256 NSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTA------ 309
N + +++ E D ++ L + I+++ ++K ++ D ++ + LTA
Sbjct: 891 NDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE 950
Query: 310 -EYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHK 368
E ++ I +LEL + K + + N + L +E + + + K+ ++ L+ AH+
Sbjct: 951 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010
Query: 369 VCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE-----EQQKRKLLYQNVDELHRQVRT 423
L D Q E+K+ T+ + K++QQ + EQ+K+ + +L R R
Sbjct: 1011 QTLDDL-----QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----DLERAKRK 1060
Query: 424 LQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ-ELSEKLSKLQQEKEA 482
L+ L QE+++ +ENEK++ DE +K + E+S SK++ E +A
Sbjct: 1061 LEGDLKLA-------------QESIM-DIENEKQQLDEKLKKKEFEISNLQSKIEDE-QA 1105
Query: 483 LREEYLRLLKLLNVHVRNYNEKHHQQKV--------------KLQKVKYRL-------TN 521
L + + +K L + E+ ++ +L+++ RL +
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1165
Query: 522 EVELRDKRINQFED-----EIGILQHKI------EKEKAIQDQITAQNDTLLLEKRKLQE 570
++E+ KR +F+ E LQH+ +K ++ Q D L K+KL++
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 571 QVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGE 630
+ E + I + ++ ++K + L++ L + +R+I + +RG
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR 1285
Query: 631 NLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQ 690
E K A + + K + FT EL+ + E +A H+ Q
Sbjct: 1286 LQTESGEFSRQLDEKEALVSQLSRGK-----QAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 691 METTISDILESEVVNE---ILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEK 747
D+L + E L + V + + ET+ I+ E + +K +K
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK--KK 1398
Query: 748 SPENL-VCSQNSEAGYINVASLKET 771
+ L ++ EA ASL++T
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKT 1423
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 95.1 bits (235), Expect = 2e-19
Identities = 120/581 (20%), Positives = 261/581 (44%), Gaps = 55/581 (9%)
Query: 18 EREKQLASGLDTAEK---ALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
E +K+LA L AE+ A+ + L+K+K L NEV +L + E + A D
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL---QNEVEDLMLDVERTNAACAALDK 1450
Query: 75 LQRENSELETK-VLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
QR ++ + K + A+L ++ + L +N ++ L+ E ++
Sbjct: 1451 KQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKN 1510
Query: 134 RKEETEELCPKLGE---------RKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEK 184
++E +L ++ E + +K++ +E + + E + ++ + ++ + +
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 185 EQQLTMKPE-EIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
Q+ + + +I EE+ + ++ ++ S S+ D+ + + +LK +G++ +
Sbjct: 1571 LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630
Query: 244 LHQNLHRLQILCNSAENELRYERGQNLDLKQH--NSLLQEENIKIKIELKHAQQKLLDST 301
+ L+ + A R +G D + H ++L +E++K ++ + + LL +
Sbjct: 1631 MEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAE 1690
Query: 302 KMCSSLTAEYKHCQQKIKELEL-EVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQ 360
T E +KI E EL + + Q + +QN L+ K K+ E I +Q
Sbjct: 1691 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT---SLINTKKKL---ETDISQMQ 1744
Query: 361 RKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ 420
++E + E + EEK K+A + A + ++ ++EQ L + + +
Sbjct: 1745 GEMEDI---------LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 421 VRTLQDK-ENLLEMTCSQQQSRIQQQEALLKQLE----NEKRKYDEHVKSNQELSEKLSK 475
V+ LQ + + ++ + +IQ+ EA +++LE +E+++ E VK ++ ++ +
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 476 LQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFED 535
L + E R+ LRL L++ Q KVK K + E +++ N
Sbjct: 1856 LTYQTEEDRKNILRLQDLVD---------KLQAKVKSYK------RQAEEAEEQSNTNLA 1900
Query: 536 EIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQE 576
+ LQH++E+ + D +Q + L ++ R++ +VI +E
Sbjct: 1901 KFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 82.4 bits (202), Expect = 1e-15
Identities = 140/740 (18%), Positives = 301/740 (40%), Gaps = 68/740 (9%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEV-HNLPGESESKDHFLIACD 73
K + +L +D ++ ++L+K KSE+ +++ N+ S++K + C
Sbjct: 1201 KHADSVAELGEQIDNLQRV----KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 74 LLQRENSELETKVLK----LSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILET 129
L+ + SEL++K + ++ AQ L E +
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 130 EIQSRKEETEELCPK---LGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQ 186
+I+ K + EE L Q + + + E + + Q+ + E Q
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 187 QLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQ 246
T + ++ EEL + L Q + + ++ +S EK K Q EV+ L
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 247 NLHRLQILCNSAENELRYERGQNLDLKQ-----HNSL--LQEENIKIKIELKHAQQKLLD 299
++ R C + + + R + KQ H L Q+E + EL + +
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 300 STKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADA------- 352
S +L E K+ QQ+I +L ++ + + I +++++ QEK ++ A
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 353 ----EEKILDLQRKLEHA-----HKVCLTDTCISEKQQLEEKIKEATQN--EAKVKQQYQ 401
E KIL +Q +L K+ D I + ++ +I E+ Q+ +A+++ +
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 402 EEQQKRKLLYQNVDELHRQV-----------RTLQDKENLLEMTCSQQQSRIQQQEALLK 450
+ K+K+ +++E+ Q+ R ++ + +L+ T ++ QE L +
Sbjct: 1617 AIRLKKKM-EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675
Query: 451 QLENEKRKYD------EHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEK 504
QL +R+ + E +++ E +E+ K+ +++ E ++LL N + N +K
Sbjct: 1676 QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 505 HHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLE 564
++Q + E +++ + + ++ +++KE+ + +
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 565 KRKLQEQVIEQEQL-IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRS 623
+ LQ ++ E EQL + K I +++RV ++ E + Q+ + + + ER ++
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 624 IHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATE 683
+ + E+ K + A + K+Q E + E +N A+ + + EA E
Sbjct: 1856 LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEEAEE 1914
Query: 684 KWKHSEQMETTISDILESEV 703
+ +DI ES+V
Sbjct: 1915 R-----------ADIAESQV 1923
Score = 77.0 bits (188), Expect = 6e-14
Identities = 117/531 (22%), Positives = 217/531 (40%), Gaps = 107/531 (20%)
Query: 285 KIKIELKHAQ--QKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKL 342
KIK LK A+ +++ + + E + K KELE +++ +K +N+LQ ++
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVT---LLKEKNDLQLQV 897
Query: 343 VQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE 402
E +ADAEE+ D I K QLE KIKE T+
Sbjct: 898 QAEAEGLADAEER----------------CDQLIKTKIQLEAKIKEVTERA--------- 932
Query: 403 EQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEH 462
++ +E++ + L K+ LE CS+ + I E L ++E EK +
Sbjct: 933 ---------EDEEEINAE---LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 463 VKSNQE----LSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYN---------------- 502
VK+ E L E ++KL +EK+AL+E + + L L N
Sbjct: 981 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL 1040
Query: 503 ----EKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQN 558
E+ + ++ L++ K +L +++L + I E+E L K++K++
Sbjct: 1041 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE---------- 1090
Query: 559 DTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLE 618
E LQ ++ +++ L + I +Q+R+ +++E + + + + +Q L
Sbjct: 1091 ----FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 619 RIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESV 678
R + I E L+E A + KK++ + A LQHE
Sbjct: 1147 RELEEI----SERLEEA------GGATSAQIEMNKKREAEFQKMRRDLEEATLQHE---A 1193
Query: 679 PEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSK-- 736
AT + KH++ + I + V + L S K ++ AS ET K+K
Sbjct: 1194 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM--KMEIDDLASNVETVS-KAKGN 1250
Query: 737 ---------EAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQD 778
+ ++ KS E+ + L+ ++ G + S + + + E++
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301
Score = 73.6 bits (179), Expect = 7e-13
Identities = 116/565 (20%), Positives = 234/565 (41%), Gaps = 81/565 (14%)
Query: 256 NSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTA------ 309
N + +++ E D ++ L + I+++ ++K ++ D ++ + LTA
Sbjct: 891 NDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE 950
Query: 310 -EYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHK 368
E ++ I +LEL + K + + N + L +E + + + K+ ++ L+ AH+
Sbjct: 951 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010
Query: 369 VCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE-----EQQKRKLLYQNVDELHRQVRT 423
L D Q E+K+ T+ + K++QQ + EQ+K+ + +L R R
Sbjct: 1011 QTLDDL-----QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-----DLERAKRK 1060
Query: 424 LQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ-ELSEKLSKLQQEKEA 482
L+ L QE+++ +ENEK++ DE +K + E+S SK++ E +A
Sbjct: 1061 LEGDLKLA-------------QESIM-DIENEKQQLDEKLKKKEFEISNLQSKIEDE-QA 1105
Query: 483 LREEYLRLLKLLNVHVRNYNEKHHQQKV--------------KLQKVKYRL-------TN 521
L + + +K L + E+ ++ +L+++ RL +
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1165
Query: 522 EVELRDKRINQFED-----EIGILQHKI------EKEKAIQDQITAQNDTLLLEKRKLQE 570
++E+ KR +F+ E LQH+ +K ++ Q D L K+KL++
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 571 QVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGE 630
+ E + I + ++ ++K + L++ L + +R+I + +RG
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR 1285
Query: 631 NLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQ 690
E K A + + K + FT EL+ + E +A H+ Q
Sbjct: 1286 LQTESGEFSRQLDEKEALVSQLSRGK-----QAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 691 METTISDILESEVVNE---ILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEK 747
D+L + E L + V + + ET+ I+ E + +K +K
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK--KK 1398
Query: 748 SPENL-VCSQNSEAGYINVASLKET 771
+ L ++ EA ASL++T
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKT 1423
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 94.7 bits (234), Expect = 3e-19
Identities = 141/638 (22%), Positives = 273/638 (42%), Gaps = 70/638 (10%)
Query: 1 MSQEKNEMFESEWSKER--EREKQLASGLDTAEKALKVESEELQKSK-SELICLYNEVHN 57
+ QE+ ++ E K R ERE+Q +K ++ EE +K + E Y E
Sbjct: 936 LQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE 995
Query: 58 LPGESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTC 117
L E E L+ + +R E E + K E Q L + L E
Sbjct: 996 LQQEEEQ----LLREEREKRRRQEWERQYRK-KDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 118 KDPES----NEPILETEIQSRK-EETEELCPKLGERKQKE---IPEESVKEGSFPREGQ- 168
++ E E +L E ++R+ +E E K E +Q+E + EE K RE Q
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 169 --KEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQH 226
+EE Q+ + EE+E++ + E R EE+ + LL+ + + Q
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ- 1169
Query: 227 PSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKI 286
Y ++ E+QQ + L R + E E +Y + L ++ ++E+ +
Sbjct: 1170 --------YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 287 KIELKHAQQK---LLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLV 343
++ + +K + D+ C E + ++LE L+ QS Q +LQ L
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENE------QFRQLEDSQLRDRQS---QQDLQHLLG 1272
Query: 344 QEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLE-EKIKEATQNEAKVKQQYQ- 401
+++ + D E++ Q++ H E++QLE E+ KEA + + K +++ Q
Sbjct: 1273 EQQER--DREQERRRWQQRDRH----------FPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 402 -EEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYD 460
E+++ K Q D R +++E LL+ +++ +++QE K E E R +
Sbjct: 1321 LREEREEKRRRQETD------RKFREEEQLLQ---EREEQPLRRQERDRKFREEELRHQE 1371
Query: 461 EHVKSNQELSEKLSKLQQEKEALREEYL-----RLLKLLNVHVRNYNEKHHQQKVKLQKV 515
+ K +E ++L + ++E++ L+EE R +L R + E+ Q + +
Sbjct: 1372 QGRKFLEE-EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 516 KYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ 575
K+R + R +R +F +E L+ + ++ ++Q+ + + L +++ + +E+
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 576 EQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQ 613
EQ + + + + + E K L+E QQ
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Score = 92.8 bits (229), Expect = 1e-18
Identities = 166/814 (20%), Positives = 326/814 (40%), Gaps = 97/814 (11%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEEL-------QKSKSELICLYN 53
+ +++ E W K E E++ + E+ L+ E EE Q+ + L
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQ--ERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 54 EVHNLPGESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITS 113
L E E + L+ + +R E + LK QE + L+
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR------------DQLLKR 581
Query: 114 ENTCKDPE---SNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKE 170
E + E LE ++ + E E + +R ++E PEE ++ E Q+E
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 171 EGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSS- 229
QQ R + E +EQ+L + EE RL + L ++ + Q + + + S
Sbjct: 642 RRQQQLRREQQERREQRLKREEEE-ERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 230 -------------GEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHN 276
+ K + Q+ + + E+EL+++ + + H
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE----RAHR 756
Query: 277 SLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQN 336
+EE + A++K S + L+A +Q+ ++L E + +
Sbjct: 757 QQQEEEQRRDFTWQWQAEEK---SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 337 NLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKV 396
+++ + + + + E + L+ + +L+ + QQL+E +E E +
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERA----------QQLQE--EEDGLQEDQE 861
Query: 397 KQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEK 456
+++ QE+++ +K +Q +E R+ TL K L E +QQ +Q++E L++ E EK
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ-LLQEEEEELQREEREK 920
Query: 457 RKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVK 516
R+ E + +E E+L Q+E++ LREE + R E+ +++ KLQ+ +
Sbjct: 921 RRRQEQERQYRE-EEQLQ--QEEEQLLREEREK-------RRRQERERQYRKDKKLQQKE 970
Query: 517 YRLTN---EVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVI 573
+L E R +R ++ +E + Q E++ +++ + + RK E
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 574 EQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSL----RLTQQIGFLERIIRSIHIRRG 629
E+EQL+ + + Y ++E Q +E L R T++ LER R+
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER-----QYRKE 1083
Query: 630 ENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSE 689
E L++ +L P K++++ E ELQ E+E + + + +
Sbjct: 1084 EELQQ-------EEEQLLREEPEKRRRQ--ERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 690 QMETTISDILESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSP 749
++E + E EV E L + E +E EE++ +E + EK
Sbjct: 1135 ELERQYRE--EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 750 ENLVCSQNSEAGYINVASLKETHGIQEQDQKSEL 783
+ E + K +++DQ+S+L
Sbjct: 1193 QERERQYREEE---ELQRQKRKQRYRDEDQRSDL 1223
Score = 92.0 bits (227), Expect = 2e-18
Identities = 117/577 (20%), Positives = 266/577 (46%), Gaps = 43/577 (7%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
Q + E + K +E+E++LA G + +EK ++E + Q+ EL E E
Sbjct: 128 QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE-ER 186
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPES 122
+++ L +C + E E ++ + +E +L G+ E + E
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRR--RELLELRR---KGR--------EEKQQQRRER 233
Query: 123 NEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDE 182
+ + + E + + E + K E+ Q+E P+ + + +K E + R+ ++E
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 183 EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
E++QQ + +++ R +EE Q + Q + + E+ + +Q +++
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ-QLR 352
Query: 243 QLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQ-KLLDST 301
+ + R Q L E E R ++ L++ L +E+ ++ + +L+ QQ +
Sbjct: 353 REQEEERREQQLRREQEEERREQQ-----LRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 302 KMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQR 361
+ L E + +++ E E +H Q Q +++L +E+ + D ++ + +R
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQK-HEQERREQRLKREQEERRDWLKREEETER 466
Query: 362 KLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQV 421
+ K L K+ EE+ +E + +++ Q+E+++++L + + +++
Sbjct: 467 HEQERRKQQL-------KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 422 RTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKE 481
+ +++E L + S+QQ R +Q+E + L+ E+ K E + Q +L++E+E
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ-------RLKREQE 572
Query: 482 ALREEYL-RLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGIL 540
R++ L R + ++ E+ +Q++K ++V+ RL E E R++R+ + E E
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE-RLEQE-ERREQRLKREEPEEERR 630
Query: 541 QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQ 577
Q ++ E +Q + L E+++ +EQ +++E+
Sbjct: 631 QQLLKSE----EQEERRQQQLRREQQERREQRLKREE 663
Score = 85.5 bits (210), Expect = 2e-16
Identities = 132/619 (21%), Positives = 268/619 (43%), Gaps = 67/619 (10%)
Query: 127 LETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQ 186
L+ E ++R + E L L +R+Q+E PR+ Q EE Q R K +E+E+
Sbjct: 95 LDEEKRARCDGKESL---LQDRRQEEDQRRFE-----PRDRQLEEEPGQRRRQKRQEQER 146
Query: 187 QLT------------------MKPEEIVRLREELS-----HINQSLLQSQSSGDSSDDSG 223
+L + EE+ R R+E + LQS ++ +
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206
Query: 224 AQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEEN 283
+ E L+ ++G ++ Q R + E E + R + L++ LQEE
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQ--EEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 284 IKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELE-VLKHTQSIKSQNNLQEKL 342
+ + EL+ +++L + L E + +Q+ + L E L+ Q + + +E+
Sbjct: 265 PQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 343 VQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE 402
Q++ + E + L+R+ E + L E+++ E++++ + E + +Q +E
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRRE--QEEERREQQLRREQEEERREQQLRRE 380
Query: 403 EQQKRKLLYQNVDELHR--QVRTLQDKENLLEMTCSQQQSRIQQ----QEALLKQLENEK 456
+Q +R+ + +L R Q+R Q ++ QQ R QQ QE + ++E+
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 457 RKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVK 516
+ ++ +K QE E+ L++E+E R E R + L R+ E+ ++ +KL++ +
Sbjct: 441 ERREQRLKREQE--ERRDWLKREEETERHEQERRKQQLK---RDQEEERRERWLKLEEEE 495
Query: 517 YRLTNE----------VELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKR 566
R E E R++R+ + E+E LQ ++ E+ ++ + + + LL +
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEE-ERLQQRLRSEQQLRREQEERREQLL---K 551
Query: 567 KLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQ---LQENSLRLTQQIGFLERIIRS 623
+ +E+ +EQE+ K + ++L ++E +Q +E RL Q++ E
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 624 IHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATE 683
RR + LK + + L S +++++ E L+ E+E +
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-ERLEQ 670
Query: 684 KWKHSEQMETTISDILESE 702
+ K + E ++ E E
Sbjct: 671 RLKREHEEERREQELAEEE 689
Score = 81.3 bits (199), Expect = 3e-15
Identities = 144/660 (21%), Positives = 271/660 (41%), Gaps = 112/660 (16%)
Query: 3 QEKNEMFESEWSKEREREKQLA--SGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
Q+++ F E ERE +K+ EK L E E ++ + E + E L
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 61 ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
E E + L+R+ + K +E +L H G K + E +
Sbjct: 1347 EREEQP--------LRRQERDR-----KFREE--ELRHQEQGRK-----FLEEEQRLRRQ 1386
Query: 121 ESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGS--QQNRD 178
E L+ E Q R +E E+ + +RK +E E+ + R+ ++EE +Q R+
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFRE-EEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 179 MKDEEKEQQLTMKPEEIVRLREEL-SHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQ 237
K E+EQQL + R E+L + L Q + Q K+ +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 238 QG------------EVQQLHQNLHRLQILCNSAENELR-YERGQNLDLKQHNSLLQEENI 284
Q E QQLH+ + + L E +LR ERGQ + +EE +
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFL--QEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 285 KIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIK--ELELEVLKHTQSIKSQNNLQEKL 342
+ + E + ++ D +++ +QK++ E E + ++ Q ++ Q Q++L
Sbjct: 1564 RQEREEQQLSRQERDR---------KFRLEEQKVRRQEQERKFMEDEQQLRRQEG-QQQL 1613
Query: 343 VQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQL-------------------- 382
QE+ + +E++L +R+ + H+ + E+ QL
Sbjct: 1614 RQERDRKFREDEQLLQ-EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 383 EEKIKEATQNEAK----------VKQQYQEEQQKRKLLYQNVDELHRQ--VRTLQDKENL 430
E+ ++E + + + +QQ + ++++RK L Q +L RQ R +++E L
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL-QEEQQLRRQELERKFREEEQL 1731
Query: 431 LEMTCSQQQSRIQQQEALLKQLENE--KRKYDEHVKSNQELSEKLSKLQQEKEALREEYL 488
+ T +Q ++++QE K LE E + + +E QE K + +Q ++ E+ L
Sbjct: 1732 RQET---EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL 1788
Query: 489 RL----LKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNE---VELRDKRINQFEDEIGILQ 541
R K + Q + + + KYR E +E +++R+ Q D Q
Sbjct: 1789 RSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDR----Q 1844
Query: 542 HKIEKEKAIQDQITAQNDTLLLE---------KRKLQEQVIEQEQLIHSNKWTISSIQSR 592
++ E++ A Q++ + L E +RKL+E+ I ++Q + I+S+
Sbjct: 1845 YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Score = 79.0 bits (193), Expect = 2e-14
Identities = 119/601 (19%), Positives = 261/601 (43%), Gaps = 69/601 (11%)
Query: 130 EIQSRKEETEELCPKLGERKQKEIPEESVKEGSFP--REGQKEEGSQQNRDMKD---EEK 184
E + R+ E E+L G ++ EE ++ R +EE QQ R+ +D +E+
Sbjct: 182 EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241
Query: 185 EQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQL 244
E++ K E ++R EE + Q + ++ ++L+ +Q E QQ
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEP----QRQRELQEEEEQLRKLERQELRRERQEEEQQ- 296
Query: 245 HQNLHRLQILCNSAENELRY---ERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDST 301
Q L R Q L E E R ER + + ++ +E+ ++ + E + QQ +
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ- 355
Query: 302 KMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQR 361
E + +Q+++ + E + Q + Q +E+ ++ + ++ ++ + Q
Sbjct: 356 --------EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 362 KLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQV 421
+ E + +QQL + + + E + +Q E++++ + L + +E +
Sbjct: 408 RREQQ---------LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL 458
Query: 422 RTLQDKENLLEMTCSQQQSRIQQQEALLK--QLENEKRKYDEHVKSNQELSEKLSKLQQE 479
+ ++ E + QQ R Q++E + +LE E+R+ ++ + Q+L + + +++
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR-EQQERREQQLRREQEERREQ 517
Query: 480 KEALREEYLRLLKLL--NVHVRNYNEKHHQQKVKLQKVK--------YRLTNEVELRDKR 529
+ +EE RL + L +R E+ +Q +K ++ K RL E E R +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 530 INQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTI--- 586
+ + E+E + K E+E+ ++ ++ + + LE+ + +EQ +++E+ + +
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRL-KREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 587 -SSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIH--IRRGENLKE--------- 634
+ R + +E ++ +E L+ ++ LE+ ++ H RR + L E
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Query: 635 --FPVPKW-WHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDES--VPEATEKWKHSE 689
+PKW W A +Q ++YS Q ++E E+ +W+ E
Sbjct: 697 IKSRIPKWQWQLESEAD----ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE 752
Query: 690 Q 690
+
Sbjct: 753 R 753
Score = 75.5 bits (184), Expect = 2e-13
Identities = 145/717 (20%), Positives = 302/717 (42%), Gaps = 100/717 (13%)
Query: 3 QEKNEMFESEWSKERE---REKQLASG-LDTAEKALKVESEELQ-KSKSELICLYNEVHN 57
+E+ E E +E E RE++LA + A + +K + Q + +SE ++V++
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 58 LPGESESKDHFLIACDLLQRENSEL----ETKVLKLSQEFAQLNHFTLGGKTAPSNLITS 113
P + E + + +R SEL E + + QE Q FT + +
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 114 ENTCKDP---ESNEPILETEIQSRKE-----ETEELCPKLGERKQKEIP------EESVK 159
+ P E E L E + ++E E EE + +R+++E EE ++
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841
Query: 160 EGSFPREGQKEE-----------GSQQNRDMK------DEEKEQQLTM--KPEEIVRLRE 200
++ Q+EE +Q RD K +E K ++ T+ KP +LR+
Sbjct: 842 RRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK 901
Query: 201 ELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQI-LCNSAE 259
E Q LLQ + ++ + E+ +Y ++ ++QQ + L R + E
Sbjct: 902 E-----QQLLQEEEEELQREEREKRRRQEQER-QYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 260 NELRYERGQNLDLKQHNSLLQE----------ENIKIKIELKHAQQKLLDSTKMCSSLTA 309
E +Y + + L K+ L +E + + + EL+ +++LL +
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE-KRRRQ 1014
Query: 310 EYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQ--EKSKVADAEEKILDLQRKLEHAH 367
E++ +K EL+ E + + + + LQE+ Q E+ ++ EE++L +R+
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 368 KVCLTDTCISEKQQLEEKI-------KEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQ 420
++ E QQ EE++ + + E + +++ + +Q++ +LL + ++ RQ
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 421 VRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEK 480
Q +E E Q++ ++ ++E ++ + +R+Y E + QE + L + Q+++
Sbjct: 1135 ELERQYRE---EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191
Query: 481 EALREEYLRLLKLLNVHVRNYNEKHHQQKVKL----------------------QKVKYR 518
RE R + L R + Q+ L + ++R
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251
Query: 519 LTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQL 578
+ +LRD++ Q D +L + E+++ + + Q D E +EQ+ +EQ
Sbjct: 1252 QLEDSQLRDRQSQQ--DLQHLLGEQQERDREQERRRWQQRDRHFPE----EEQLEREEQK 1305
Query: 579 IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEF 635
+ S + ++L ++E K+ ++ + R ++ L + +RR E ++F
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362
Score = 65.5 bits (158), Expect = 2e-10
Identities = 110/547 (20%), Positives = 230/547 (42%), Gaps = 77/547 (14%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
+E+ + E + + +ERE+QL D K EE Q S+ E + E
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDR-----KFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPES 122
E + FL L++E + +L QE + L + + E + E
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ---LHRQERDRKFLEEEQQLRRQER 1499
Query: 123 NEPILETEIQSRKEET----EELCPKLGERKQKEIPEESV---KEGSFPREGQKEEGSQQ 175
+ E E++S++ E EE +R++K + EE +E R ++ ++
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE 1559
Query: 176 NRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKY 235
++ E +EQQL+ + E + R E + + Q Q D+ + ++L+
Sbjct: 1560 EEQLRQEREEQQLS-RQERDRKFRLEEQKVRR---QEQERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 236 N------------QQGEVQQLHQNLH-------RLQILCNSAENELRYERGQNLDLKQHN 276
Q+ E QQLH+ Q+ E +LR++R + ++
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF--REEE 1673
Query: 277 SLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQ--QKIKELELEVLKHTQSIKS 334
LLQE + ++ + +K + + E K Q Q+++ ELE + +
Sbjct: 1674 QLLQEGEEQ-QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE-----RKFRE 1727
Query: 335 QNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLT----DTCISEKQQLEEKIKEAT 390
+ L+++ QE+ + + KIL+ ++ + L D E++QL ++ +E
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 391 ----------QNEAKVKQQYQEEQ---QKRKLLYQ------NVDELHRQVRTLQDKE-NL 430
+ E +++Q+ +E+Q Q+R Y+ ++E +++R +D++
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA 1847
Query: 431 LEMTCSQQQSR-----IQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALRE 485
E +Q++SR + Q+E ++ E E++ +EH++ Q+ ++ ++ + K +
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Query: 486 EYLRLLK 492
+ RLL+
Sbjct: 1908 GHGRLLE 1914
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.7 bits (234), Expect = 3e-19
Identities = 154/766 (20%), Positives = 307/766 (40%), Gaps = 123/766 (16%)
Query: 30 AEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENSELETKVLKL 89
AEK + E+ +++K EL SE++ ELE K++ L
Sbjct: 849 AEKEMATMKEDFERTKEEL-----------ARSEAR-------------RKELEEKMVSL 884
Query: 90 SQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILET---EIQSRKEETEELCPKLG 146
QE N L ++ NL+ +E C+ ++ +LE E+ R EE EE+ +L
Sbjct: 885 LQE---KNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELV 941
Query: 147 ERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHIN 206
+K+ K S R+ E + + + E ++ EE+ L E +S +
Sbjct: 942 AKKR----NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLT 997
Query: 207 QSLLQSQSSGDSS-DDSGAQHPSSGEKLKYNQ---------QGEVQQLHQNLHRLQILCN 256
+ Q + + DD + +K N +G ++Q + L+
Sbjct: 998 KEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR 1057
Query: 257 SAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQ 316
E +L+ + +DL+ ++E+ K + EL Q K+ D + K Q
Sbjct: 1058 KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117
Query: 317 KIKELELEV-LKHT---QSIKSQNNLQEKLVQEKSKVADA--------------EEKILD 358
+I+ELE E+ +HT + K +++L +L + ++ +A E +
Sbjct: 1118 RIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177
Query: 359 LQRKLEHAHKVCLTDTCISEKQQLEE--KIKEATQNEAKVKQQYQEEQQKRKLLYQNVDE 416
++R LE A K+Q + ++ E N +VKQ+ ++E+ + K+ +D+
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKM---EIDD 1234
Query: 417 LHRQVRTLQDKENLLEMTC-------SQQQSRIQQQEALLKQLENEKRKYDEHVKSNQEL 469
+ + L ++ +E TC S+ +++ +QQ L+ L +K + N EL
Sbjct: 1235 MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ---TQNGEL 1291
Query: 470 SEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKR 529
S ++ +EKE+L + + + L + + ++ + + L + D
Sbjct: 1292 SHRV----EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLL 1347
Query: 530 INQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ-EQLIHSNKWTISS 588
Q+E+E E + +Q ++ N + + K + I++ E+L + K
Sbjct: 1348 REQYEEE-------QEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 589 IQSRVLYMDKENKQ---LQENSLRLTQQIGFLERIIRSIH-----IRRGENLKEFPVPKW 640
+Q + N + L++ RL ++ L R + H + + + + + +W
Sbjct: 1401 LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEW 1460
Query: 641 WHR--GKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDI 698
+ A L +K+ STE+F NA +E V + + ++ ++ ISD+
Sbjct: 1461 KQKLDESQAELEAAQKESRSLSTELFKMRNA----YEEVVDQLETLRRENKNLQEEISDL 1516
Query: 699 LESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKS 744
E + E+ +LQE E K+K+ + KS
Sbjct: 1517 TEQ------------------IAETGKNLQEAE--KTKKLVEQEKS 1542
Score = 94.0 bits (232), Expect = 5e-19
Identities = 146/725 (20%), Positives = 302/725 (41%), Gaps = 66/725 (9%)
Query: 19 REKQLASGLDTAEKA--LKVESEELQKSKSELICLYNEV-HNLPGESESKDHFLIACDLL 75
R+KQ S + E+ L+ ++L+K KSEL +++ N+ S+SK + C +
Sbjct: 1197 RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTV 1256
Query: 76 QRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRK 135
+ + SE++ K + +Q LN +T L + ++ ES L Q+
Sbjct: 1257 EDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGEL---SHRVEEKESLISQLTKSKQALT 1313
Query: 136 EETEELCPKLGERKQKEIP-----EESVKEGSFPREGQKEEGS-----QQNRDMKDEEKE 185
++ EEL ++ E + + + S + RE +EE Q+ + E
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373
Query: 186 QQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLH 245
Q T + ++ EEL + L Q + + ++ +S EK K QGEV+ L
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Query: 246 QNLHRLQILCNSAENELR------YERGQNLDLKQHN-SLLQEENIKIKIELKHAQQKLL 298
++L R C + + + R E Q LD Q Q+E+ + EL +
Sbjct: 1434 RDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE 1493
Query: 299 DSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILD 358
+ +L E K+ Q++I +L ++ + ++++ ++ + QEKS D + + +
Sbjct: 1494 EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKS---DLQVALEE 1550
Query: 359 LQRKLEHAH-KVCLTDTCISE-KQQLEEKIKEATQNEAKVKQQYQEEQQKRKLL----YQ 412
++ LEH K+ +S+ K +L+ K+ E + ++K+ Q + + + +
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610
Query: 413 NVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLK----QLENEKRKYDEHVKSNQE 468
+ ++ R + ++ N +E+ ++ + + L+ QL++ + D+ ++SN++
Sbjct: 1611 SRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED 1670
Query: 469 LSEKLSKLQQEKEALREEYLRLLKLL--NVHVRNYNEKH-----------HQQKVKLQKV 515
L E+L+ +++ L EE + L R +E+ H Q L
Sbjct: 1671 LKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730
Query: 516 KYRLTNEV------------ELR--DKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTL 561
K +L ++ E R +++ + + ++ +++KE+ + L
Sbjct: 1731 KKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 562 LLEKRKLQEQVIEQEQL-IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERI 620
+ LQ ++ E EQL + K I +++RV ++ E Q+ + ER
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERK 1850
Query: 621 IRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFT--SNNAELQHEDESV 678
++ + + E+ K + A + K+Q E + T S +QHE E
Sbjct: 1851 VKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEA 1910
Query: 679 PEATE 683
E +
Sbjct: 1911 AERAD 1915
Score = 77.8 bits (190), Expect = 4e-14
Identities = 101/500 (20%), Positives = 215/500 (43%), Gaps = 46/500 (9%)
Query: 277 SLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQN 336
SLLQE+N ++++++ + L+D+ + C L + K+KEL T+ ++ +
Sbjct: 883 SLLQEKN-DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKEL-------TERLEEEE 934
Query: 337 NLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCIS-EKQQLEEKIKEATQNEAK 395
+ +LV +K + E+K L+R ++ LT T + EK E K+K ++
Sbjct: 935 EMNSELVAKKRNL---EDKCSSLKRDIDDLE---LTLTKVEKEKHATENKVKNLSEEMTA 988
Query: 396 VKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKEN-------LLEMTCSQQQSRIQQQEAL 448
+++ + +++K L + + ++ +DK N LE + ++Q++ L
Sbjct: 989 LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKL 1048
Query: 449 LKQLENEKRKYDEHVKSNQE-LSEKLSKLQQEKEALREEYLRLLKLL------NVHVRNY 501
LE KRK + +K +QE + + + QQ +E L+++ L +L VH +
Sbjct: 1049 RADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQF 1108
Query: 502 NEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTL 561
+K + + ++++++ + E LR K Q D L+ E+ + +AQ +
Sbjct: 1109 QKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
Query: 562 LLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERII 621
+ + Q+ + E+ ++ T ++++ K+ ++ L +QI L+R+
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLR----------KKQADSVAELGEQIDNLQRVK 1218
Query: 622 RSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEA 681
+ + + E E + +L +K E + +E++ +DE +
Sbjct: 1219 QKLEKEKSELKMEIDD----MASNIEALSKSKSNIE-RTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 682 TEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFASL--QETEEIKSKEAM 739
+ T + L V + +S + S + L + L Q EE K+K AM
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAM 1333
Query: 740 ASSKSPEKSPENLVCSQNSE 759
A + + +L+ Q E
Sbjct: 1334 AHALQSSRHDCDLLREQYEE 1353
Score = 60.1 bits (144), Expect = 8e-09
Identities = 58/305 (19%), Positives = 138/305 (45%), Gaps = 28/305 (9%)
Query: 348 KVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKR 407
K A+AE+++ ++ E + + +++LEEK+ Q + ++ Q Q E +
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSE--ARRKELEEKMVSLLQEKNDLQLQVQSETE-- 900
Query: 408 KLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQ 467
N+ + + L + LLE + R++++E + +L +KR ++ S +
Sbjct: 901 -----NLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 468 ----ELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEV 523
+L L+K+++EK A + L + + N + K ++K LQ+ + +++
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENIS-KLTKEKKSLQEAHQQTLDDL 1014
Query: 524 ELRDKRIN-------QFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ- 575
++ + ++N + E + L+ +E+EK ++ + L + + QE +++
Sbjct: 1015 QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 576 ------EQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRG 629
E+ + ++ +S +Q+++ + Q Q+ L +I LE I + H R
Sbjct: 1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRA 1134
Query: 630 ENLKE 634
+ K+
Sbjct: 1135 KIEKQ 1139
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 94.0 bits (232), Expect = 5e-19
Identities = 117/559 (20%), Positives = 245/559 (43%), Gaps = 56/559 (10%)
Query: 18 EREKQLASGLDTAEK---ALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
E +K+LA L +E+ A+ + L+K+K L EV +L + E + A D
Sbjct: 1389 EAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRL---QGEVEDLMVDVERANSLAAALDK 1445
Query: 75 LQRE-NSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
QR + L K + A+L ++ + L +N ++ ++ E ++
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505
Query: 134 RKEETEELCPKLGE-----------RKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDE 182
++E +L ++ E RKQ E+ + ++ ++ E + ++ + K
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL-----EEAEAALEHEEAKIL 1560
Query: 183 EKEQQLTMKPEEIVRL----REELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQ 238
+ +LT EI R EE+ + ++ ++ + S+ D+ + + +LK +
Sbjct: 1561 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME 1620
Query: 239 GEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQH--NSLLQEENIKIKIELKHAQQK 296
G++ ++ L LR +GQ D + H ++L +E++K ++ + +
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680
Query: 297 LLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKI 356
LL + L A + ++ K E E+L + ++ + L+ K K+ E +
Sbjct: 1681 LLQAE--VEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL---ETDL 1735
Query: 357 LDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDE 416
+ LQ ++E A + + + EEK K+A + A + ++ ++EQ L +
Sbjct: 1736 MQLQSEVEDASR---------DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1786
Query: 417 LHRQVRTLQDK-ENLLEMTCSQQQSRIQQQEALLKQLE----NEKRKYDEHVKSNQELSE 471
L + V+ LQ + + ++ + +IQ+ E +++LE E++K E VK ++
Sbjct: 1787 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYER 1846
Query: 472 KLSKLQQEKEALREEYLRLLKL---LNVHVRNY----NEKHHQQKVKLQKVKYRLTNEVE 524
++ +L + E R+ LRL L L V V++Y E Q L K + + +E+E
Sbjct: 1847 RVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFR-KAQHELE 1905
Query: 525 LRDKRINQFEDEIGILQHK 543
++R + E ++ L+ K
Sbjct: 1906 EAEERADIAESQVNKLRAK 1924
Score = 86.7 bits (213), Expect = 8e-17
Identities = 142/683 (20%), Positives = 288/683 (42%), Gaps = 82/683 (12%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHN-LPGESESKDHFLIACD 73
K + +L +D ++ ++L+K KSE +++ + + S+SK + C
Sbjct: 1196 KHADSVAELGEQIDNLQRV----KQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251
Query: 74 LLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
L+ + SE K ++ + ++L +T L ++ ES L Q+
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL---SRQLEEKESIVSQLSRSKQA 1308
Query: 134 RKEETEELCPKLGERKQKEIP-----EESVKEGSFPREGQKEEGS-----QQNRDMKDEE 183
++TEEL +L E + + + S + RE +EE Q+ + E
Sbjct: 1309 FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368
Query: 184 KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
Q T + ++ EEL + L Q + ++ +S EK K QGEV+
Sbjct: 1369 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVED 1428
Query: 244 LHQNLHRLQILCNS------------AENELRYERGQ---NLDLKQHNSLLQEENIKIKI 288
L ++ R L + AE + + E Q LK+ SL E
Sbjct: 1429 LMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE-----LF 1483
Query: 289 ELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSK 348
+LK+A ++ LD + ++ E K+ +Q+I +L ++ ++ ++I ++++ EK
Sbjct: 1484 KLKNAYEEALDQLE---TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK-- 1538
Query: 349 VADAEEKILDLQRKLEHAH-KVCLTDTCISE-KQQLEEKIKEATQNEAKVKQQYQEE--- 403
AD + + + + LEH K+ +++ K +++ KI E + ++K+ YQ
Sbjct: 1539 -ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVET 1597
Query: 404 -QQKRKLLYQNVDELHRQVRTLQDKENLLEMTCS----QQQSRIQQQEALLKQLENEKRK 458
Q ++ +E R + ++ N +E+ S Q ++ ++ QL++ +
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 459 YDEHVKSNQELSEKLS-------KLQQEKEALR---EEYLRLLKLLNVHVRNYNEK---- 504
D+ ++ ++L E+L+ LQ E E LR E+ R KL + + NE+
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLL 1717
Query: 505 HHQQ------KVKLQKVKYRLTNEVELRDKRINQFED-------EIGILQHKIEKEKAIQ 551
H Q K KL+ +L +EVE + E+ + ++ +++KE+
Sbjct: 1718 HTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTS 1777
Query: 552 DQITAQNDTLLLEKRKLQEQVIEQEQL-IHSNKWTISSIQSRVLYMDKENKQLQENSLRL 610
+ L + LQ ++ E EQL + K I +++R+ ++ E + Q+ +
Sbjct: 1778 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTES 1837
Query: 611 TQQIGFLERIIRSIHIRRGENLK 633
+ + ER ++ + + E+ K
Sbjct: 1838 VKGLRKYERRVKELTYQSEEDRK 1860
Score = 77.8 bits (190), Expect = 4e-14
Identities = 114/573 (19%), Positives = 237/573 (41%), Gaps = 69/573 (12%)
Query: 242 QQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDST 301
++L + L L N + +++ E LD ++ L + +++ ++K ++ D
Sbjct: 872 KELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEE 931
Query: 302 KMCSSLTA-------EYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEE 354
++ + LTA E ++ I +LEL + K + + N + L +E S + +
Sbjct: 932 EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA 991
Query: 355 KILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQE-----EQQKRKL 409
K+ ++ L+ AH+ L D Q E+K+ + ++K++QQ ++ EQ+K+
Sbjct: 992 KLTREKKALQEAHQQALDDL-----QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLR 1046
Query: 410 LYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQEL 469
+ +L R R L+ L QE++L LEN+K++ DE +K
Sbjct: 1047 V-----DLERNKRKLEGDLKLA-------------QESIL-DLENDKQQLDERLKKKDFE 1087
Query: 470 SEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKR 529
+L ++++ L ++ + +K L + E+ ++ K + + ++ ++
Sbjct: 1088 YCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEEL 1147
Query: 530 INQFEDEIGILQHKIEKEKAIQ----------DQITAQNDTLLLEKRKLQ-EQVIEQEQL 578
+ E+ G+ +IE K + ++ T Q++ ++ RK + V E +
Sbjct: 1148 SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ 1207
Query: 579 IHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIR----RGEN--- 631
I + + ++ E L + +++ LE+I R++ + RG+N
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267
Query: 632 ---LKEFPVPKWWHRGKLASLPPTKKQKEIY------STEVFTSNNAELQHEDESVPEAT 682
L E K + + L ++KE S + FT EL+ + E +A
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK 1327
Query: 683 EKWKHSEQMETTISDILESEVVNE---ILPLSNSSFSGKGLVESFASLQETEEIKSKEAM 739
H+ Q D+L + E L + V + + ET+ I+ E +
Sbjct: 1328 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1387
Query: 740 ASSKSPEKSPENLVCSQNS-EAGYINVASLKET 771
+K +K + L S+ EA ASL++T
Sbjct: 1388 EEAK--KKLAQRLQDSEEQVEAVNAKCASLEKT 1418
Score = 37.0 bits (84), Expect = 0.071
Identities = 55/224 (24%), Positives = 91/224 (40%), Gaps = 48/224 (21%)
Query: 448 LLKQLENEK----------RKYDEHVKSN---QELSEKLSKLQQEKEALREEYLRLLKLL 494
LLK E EK + DE KS +EL EKL L QEK L+ L
Sbjct: 840 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQ---------L 890
Query: 495 NVHVRNYNEKHHQQKV-KLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQ 553
V + N +++ +L K K+ Q E +I + + E E+ I +
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKF--------------QLEAKIKEVTERAEDEEEINAE 936
Query: 554 ITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQ 613
+TA +KRKL+++ E ++ I + T++ ++ + + K L E L +
Sbjct: 937 LTA-------KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989
Query: 614 IGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKE 657
I L R +++ + L + K+ SL TK + E
Sbjct: 990 IAKLTREKKALQEAHQQALDDLQA----EEDKVNSLNKTKSKLE 1029
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 94.0 bits (232), Expect = 5e-19
Identities = 164/802 (20%), Positives = 336/802 (41%), Gaps = 99/802 (12%)
Query: 37 ESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENSELETKVLKLSQEFAQL 96
+ EELQ EL+ + + + GE E + ++ LE K + Q A+
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEME---------RKHQQLLEEKNILAEQLQAET 900
Query: 97 NHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKL-GERKQKEIPE 155
F A + + + K E E + +++SR EE EE L E+K+ +
Sbjct: 901 ELF------AEAEEMRARLAAKKQELEEIL--HDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 156 ESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHI--NQSLLQSQ 213
+ ++E + +EEG++Q ++ E ++ EEI+ L ++ S + L++ +
Sbjct: 953 QDLEE-----QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 214 SSGDSSDDSGAQHPSSG-EKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDL 272
+ SS + + + K++ Q+ + L + L + + E R G+ DL
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 273 KQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSI 332
+ + LQ + ++K++L +++L + T + + ++EL+ ++ +
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE----- 1122
Query: 333 KSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCIS-------------EK 379
LQE EK+ AE++ DL +LE A K L DT + E
Sbjct: 1123 -----LQEDFESEKASRNKAEKQKRDLSEELE-ALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 380 QQLEEKIKEATQN-EAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQ 438
+L++ ++E T+N EA+++ Q + L + +++ R L+ + LE +
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 439 QSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHV 498
++ + + + E++++K D V QEL K+S+ + + L E+ +L L+ +V
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQV---QELHAKVSEGDRLRVELAEKASKLQNELD-NV 1292
Query: 499 RNYNEKHHQQKVKLQKVKYRLTNEV---------ELRDK-----RINQFEDEIGILQHKI 544
E+ ++ +K K L +++ E R K RI Q E+E LQ +
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 545 EKE----KAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISS-------IQSRV 593
E+E K ++ Q+ A L K+K+ + + E L + K + ++ +
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 594 LYMDKENK---QLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLP 650
L DK K +LQ+ LT + ++ ++ ++ K+F + A
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ----KKFDQLLAEEKSISARYA 1468
Query: 651 PTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILES--EVVNEIL 708
+ + E + E T + + +E++ E + ++Q+ + D++ S +V +
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH 1528
Query: 709 PLSNSSFSGKGLVESFAS--------LQETEEIKSK--EAMASSKSPEKSPENLVCSQNS 758
L S + + VE + LQ TE+ K + M + K+ + QN
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 759 EAGYINVASLKETHGIQEQDQK 780
E + + ++E E ++K
Sbjct: 1589 EKKRLLIKQVRELEAELEDERK 1610
Score = 79.7 bits (195), Expect = 1e-14
Identities = 123/642 (19%), Positives = 268/642 (41%), Gaps = 103/642 (16%)
Query: 1 MSQEKNEMFESEWSKERER---EKQLAS--------------------GLDTAEKALKVE 37
+ +EKN + E + +E R EKQ+ + L+ A+K L +
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400
Query: 38 SEELQKSKSELICLYNEVHNLPGESESK-DHFLIACDLLQRENSELETKVLKLSQEFAQL 96
+E L + E Y+++ + + D + D ++ S LE K K Q A+
Sbjct: 1401 AEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460
Query: 97 NHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEI--- 153
++ + A +E ++ E+ L ++ E EE ER+ K++
Sbjct: 1461 K--SISARYAEER-DRAEAEAREKETKALSLARALEEALEAKEEF-----ERQNKQLRAD 1512
Query: 154 ------PEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQ 207
++ V + E K QQ +M+ + +E + ++ E +LR E +N
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE---VNM 1569
Query: 208 SLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERG 267
+++Q D + ++L Q E++ ++ + + L +++ ++
Sbjct: 1570 QAMKAQFERDLQTRD--EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME---- 1623
Query: 268 QNLDLKQHNSLLQEENI----------KIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQK 317
+DLK + ++ N K++ ++K Q++L ++ + A+ K ++K
Sbjct: 1624 --IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681
Query: 318 IKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCIS 377
+K LE E+L+ + + S + QE+ ++AD E + +
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELAD------------EITNSASGKSALLD 1729
Query: 378 EKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQ 437
EK++LE +I A+++++ +EEQ +LL + QV TL + E E + +Q
Sbjct: 1730 EKRRLEARI-------AQLEEELEEEQSNMELLNDRFRKTTLQVDTL-NAELAAERSAAQ 1781
Query: 438 QQSRIQQQ-EALLKQLENEKRKYDEHVKSN-----QELSEKLSKLQQEKEALREEYLRLL 491
+ +QQ E K+L+ + ++ + VKS L K+ +L+++ E +E
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1841
Query: 492 KLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQ 551
KL+ + + KL+++ ++ +E D+ Q E ++ + + +
Sbjct: 1842 KLV-----------RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890
Query: 552 DQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRV 593
++ T N +RKLQ ++ + + +S++++R+
Sbjct: 1891 EEATRAN----ASRRKLQRELDDATEANEGLSREVSTLKNRL 1928
Score = 78.2 bits (191), Expect = 3e-14
Identities = 161/820 (19%), Positives = 332/820 (40%), Gaps = 131/820 (15%)
Query: 14 SKEREREKQLASGLDTAEKALKVESEELQKSK-----------SELICLYNEVHNLPGES 62
+K R +++ + S L+ K + +EL+K+K ++ L ++ L +
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEF-AQLNHFTLGGKTAPSNLITSENTCKDPE 121
K+ L + + + LK+ +E AQ+ ++ ++ +E +D
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 122 SNEPILETEIQSRKEETEELCPKLGERKQKEIPE--ESVKEGSFPREGQKEEGSQQNRDM 179
L+TE++ + T +L ++++E+ E ++++E + E Q ++ Q++
Sbjct: 1146 EELEALKTELEDTLDTTAAQ-QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 180 KDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQG 239
+E EQ E+ R + L Q L Q + E +
Sbjct: 1205 LEELSEQL-----EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 240 EVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLD 299
+VQ+LH + S + LR E L + S LQ E + L+ A++K +
Sbjct: 1260 QVQELHAKV--------SEGDRLRVE------LAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 300 STKMCSSLTAEYKHCQQKIKELELEVLKHTQSIK----SQNNLQEKLVQEKSKVADAEEK 355
K +SL ++ + Q+ ++E + L + I+ +N+LQE+ +E+ + E++
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 356 ILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEE-------QQKRK 408
+L LQ +L K D + + LEE K+ ++ + Q+ +E+ ++ +
Sbjct: 1366 VLALQSQLADTKK--KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 409 LLYQNVDEL------HRQVRT-LQDKENLLEMTCSQQQS--------------------- 440
L Q +D+L RQV + L+ K+ + ++++S
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483
Query: 441 -----------RIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALR---EE 486
++ +E +Q + + ++ + S ++ + + +L++ K AL EE
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 487 YLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRD-----------KRINQFED 535
L+ L ++ + + +V +Q +K + +++ RD K++ + E
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603
Query: 536 EIG----------ILQHKIEKE-KAIQDQITAQN---DTLLLEKRKLQEQVIEQEQLIHS 581
E+ + K+E + K ++ QI A N D ++ + RKLQ Q+ + ++ +
Sbjct: 1604 ELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663
Query: 582 NKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWW 641
+ + I ++ +K+ K L+ L+L +++ ER R R E E
Sbjct: 1664 ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA-- 1721
Query: 642 HRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILES 701
GK A L ++ + A+L+ E E E + T D L +
Sbjct: 1722 -SGKSALLDEKRR---------LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 702 EVVNEILPLSNSSFSGKGL----VESFASLQETE-EIKSK 736
E+ E S + + L E A LQE E +KSK
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811
Score = 68.2 bits (165), Expect = 3e-11
Identities = 117/563 (20%), Positives = 232/563 (41%), Gaps = 87/563 (15%)
Query: 281 EENIKIKIELKHAQ--------QKLLDSTKMCSSLTAE------YKHCQQKIK-ELELEV 325
+ N ++L+H Q + LL T+ L A+ K Q K++ ELE
Sbjct: 820 QRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEME 879
Query: 326 LKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEK 385
KH Q ++ +N L E+L E A+AEE L K KQ+LEE
Sbjct: 880 RKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAK----------------KQELEEI 923
Query: 386 IKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQ 445
+ + + +++ Q Q ++K + ++ +L Q+ + L++ +++I++
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983
Query: 446 EALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNE-- 503
E + LE++ K+ + K ++ + S E+E + ++ V + + E
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 504 -KHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKI-EKEKAIQ------DQIT 555
K + + +L+K K +L E +I + + +I L+ ++ +KE+ +Q D T
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103
Query: 556 AQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQL------------ 603
+ L R+LQ Q+ E ++ S K + + + + + +E + L
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163
Query: 604 --QENSLRLTQQIGFLERI-----------IRSIHIRRGENLKEFPVPKWWHRGKLASLP 650
QE + Q++ L++ I+ + R L+E + A+L
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223
Query: 651 PTKKQKEIYSTE------VFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVV 704
K+ E + E V AE +H+ + + +A + H++ E D L E+
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKL-DAQVQELHAKVSE---GDRLRVELA 1279
Query: 705 NEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYIN 764
+ L N + L+E E + IK + AS +S + + L+ Q +N
Sbjct: 1280 EKASKLQNELDNVSTLLEE----AEKKGIKFAKDAASLESQLQDTQELL--QEETRQKLN 1333
Query: 765 VASL-----KETHGIQEQDQKSE 782
++S +E + +QEQ ++ E
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEE 1356
Score = 37.7 bits (86), Expect = 0.041
Identities = 53/312 (16%), Positives = 127/312 (40%), Gaps = 22/312 (7%)
Query: 21 KQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENS 80
K L + ++ A KA ++L+K ++++ E+ S+D +++
Sbjct: 1627 KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA---SRDEIFAQSKESEKKLK 1683
Query: 81 ELETKVLKLSQEFAQLNHFTLGGKTAPSNL---ITSENTCKDPESNEPI-LETEIQSRKE 136
LE ++L+L +E A + L IT+ + K +E LE I +E
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743
Query: 137 ETEELCPKLGERKQKEIPEESVKEGSFPREGQKEE-GSQQNRDMKDEEKEQQLTMKPEEI 195
E EE E+ E+ + ++ + + E ++++ K + QQL + +E+
Sbjct: 1744 ELEE------EQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1797
Query: 196 VRLREELSHINQSLLQSQSSG--------DSSDDSGAQHPSSGEKLKYNQQGEVQQLHQN 247
+EL +S ++ S + + A+ ++ KL + +++++
Sbjct: 1798 KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ 1857
Query: 248 LHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSL 307
+ + + + ++ + LK+ +EE + + Q++L D+T+ L
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL 1917
Query: 308 TAEYKHCQQKIK 319
+ E + +++
Sbjct: 1918 SREVSTLKNRLR 1929
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/690 (22%), Positives = 287/690 (41%), Gaps = 129/690 (18%)
Query: 21 KQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENS 80
K+L +T AL + +L++ EL +++H+L + H + LQ +
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL------ESHSTVLARELQERDQ 1630
Query: 81 ELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEP----ILETEIQSRKE 136
E++++ ++ + Q H T + L+ + + E ILE +++ K
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
Query: 137 ETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQ--------- 187
E +L Q+++ +E +EG P + Q+ ++D+EKE +
Sbjct: 1691 SLRERGREL--TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHEL 1748
Query: 188 ------------------------LTMKPEEIVRLREELSHIN-QSLLQSQSSGDSSDDS 222
L+ + +EIV L+++L Q L+ QS D++
Sbjct: 1749 QELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Query: 223 G---AQHPSSGEKLKYNQQ---GEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHN 276
AQ E L+ QQ G+ +++ + LQ A L+ G+ D K+
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
Query: 277 SLLQEENI--------------KIKIELKHAQQKLLDSTKMCSSLTAEYK---------- 312
L+EE ++ E + ++ LL + C+ E++
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
Query: 313 -HCQQKIKEL--ELEVLK-HTQSIKSQNN--------LQEKLVQEKSKVADAEEKILD-- 358
Q +KE ELE L+ +QS + Q LQE L + + + E+ +L+
Sbjct: 1929 LQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA 1988
Query: 359 -LQRKLEHAHKVCLT--DTCISEKQQLEEKIKEATQNEAKVKQQYQEE-QQKRKLLYQNV 414
L R LE + D C + +QLEE ++ +YQE+ QQ ++ L Q
Sbjct: 1989 ELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRD 2048
Query: 415 DELHRQVRTLQDKENLLEMTCSQ--QQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEK 472
+EL Q Q++E LLE + +Q Q++ IQ+++ L ++ E E+ + +S +EL
Sbjct: 2049 EELRHQ----QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH--QSVRELQLT 2102
Query: 473 LSKLQQEKEALREEYLR--LLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRI 530
L++ +QE LRE R L L + H + E +Q +KL ++ RL E+E +
Sbjct: 2103 LAQKEQEILELRETQQRNNLEALPHSHKTSPME---EQSLKLDSLEPRLQRELERLQAAL 2159
Query: 531 NQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQ 590
Q E + I+ + AQ+ L L + K +++ + +Q
Sbjct: 2160 RQTE------------AREIEWREKAQDLALSLAQTKASVSSLQEVAMF---------LQ 2198
Query: 591 SRVLYMDKENKQLQENSLRLTQQIGFLERI 620
+ VL D E ++LQ+ L LT++ ER+
Sbjct: 2199 ASVLERDSEQQRLQD-ELELTRRALEKERL 2227
Score = 81.3 bits (199), Expect = 3e-15
Identities = 130/616 (21%), Positives = 256/616 (41%), Gaps = 92/616 (14%)
Query: 15 KEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDL 74
+ERER +++ GL+ + +S SELI L + + E E L
Sbjct: 519 RERERLQEMLMGLEAKQS----------ESLSELITLREALESSHLEGE----------L 558
Query: 75 LQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPI------LE 128
L++E +E+ + + Q A+L+ KT ++L + K NE + L
Sbjct: 559 LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA--AVKLSALNEALALDKVGLN 616
Query: 129 TEIQSRKEETEELCPKLGERKQ-KEIPEESVKEGSFPREGQKEEGSQQNRDM-KDEEKEQ 186
++ +EE + +C ++ +Q + + + E RE E+ + + K EE
Sbjct: 617 QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA 676
Query: 187 QLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQ 246
+L +I +EE I + L +S+ +++ +++QLHQ
Sbjct: 677 ELQADLRDI---QEEKEEIQKKLSESRHQQEAATT------------------QLEQLHQ 715
Query: 247 NLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSS 306
R + + A E L E +++ L+ ++ D +
Sbjct: 716 EAKRQEEVLARAVQE--------------KEALVREKAALEVRLQAVERDRQDLAEQLQG 761
Query: 307 LTAEYKHCQQKIKELELE--VLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLE 364
L++ + + + E + + V++ T K Q +Q + V + +V E + L L+ E
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVT---KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE 818
Query: 365 HAHKVCLTDTCISEKQQLEEKIKEATQNEA----KVKQQYQEEQQKRKLLYQNVDELHRQ 420
+ D + Q E++ K A + + K Q +E+ +K + +Q EL +
Sbjct: 819 RSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ--ELAKA 876
Query: 421 VRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYD--------EHVKSNQELSEK 472
+ +L+ ++ LEM +QQ+ + EA+ Q E E+ + + E K L E
Sbjct: 877 LESLEREKMELEMRLKEQQT---EMEAIQAQREEERTQAESALCQMQLETEKERVSLLET 933
Query: 473 LSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEV-ELRDKRIN 531
L + Q+E ++ RL + + V E + +LQ+ + L + RD
Sbjct: 934 LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAA 993
Query: 532 QFEDEIGILQHKIEKEKAIQD---QITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISS 588
E+ +LQ K++ +K ++D Q+ AQ+D+ L ++++QE++ E ++ K
Sbjct: 994 LQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELERE 1053
Query: 589 IQSRVL-YMDKENKQL 603
S L M+KE + L
Sbjct: 1054 KASLTLSLMEKEQRLL 1069
Score = 73.2 bits (178), Expect = 9e-13
Identities = 163/830 (19%), Positives = 347/830 (41%), Gaps = 103/830 (12%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
+++ + E + + Q+ + L ++ L EE K + + L +E+ L
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQE--FAQLNHFTLGGKTAPSNLITS---ENTC 117
S L +L QR ++ E ++L+ ++E AQ+ H A + + E
Sbjct: 1323 ASLQSRLRRAEL-QRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 118 KDPESNEPILETEIQSRKEETEELCPKLGERK--QKEIPEESVKEGSFPREGQKEEGSQQ 175
+ S + E++S +E + L + GE K Q + +E++ + ++EE
Sbjct: 1382 RTARSALKLKNEEVESERERAQAL-QEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440
Query: 176 NRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKY 235
+++ EK++++ E++ L + + L Q Q S +H L
Sbjct: 1441 RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH------LPM 1494
Query: 236 NQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQ 295
Q Q+L +++ L E + Q L+L++ + +++ + +++ +LK +
Sbjct: 1495 AVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQ-DLK---K 1550
Query: 296 KLLDSTKMCSSLTAEYKH----CQQKIKELELEVLKHTQSIKSQN---NLQEK---LVQE 345
+L+ T C +L E H CQQK+ + ELE + TQ + + +L+E+ L +
Sbjct: 1551 QLV--TLECLALELEENHHKMECQQKLIK-ELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 346 KSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQ 405
S++ D E L R+L+ + S+++Q+EE ++ ++++ QE
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVK-----SQREQIEELQRQKEHLTQDLERRDQELML 1662
Query: 406 KRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENE-------KRK 458
+++ + D+ RQ + L++ ++++ ++ + Q L+++ E +R
Sbjct: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Query: 459 YDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYR 518
EH+K EK + QQE H+ E Q + +LQ + +R
Sbjct: 1723 SLEHMKLILRDKEKEVECQQE-----------------HIHELQELKDQLEQQLQGL-HR 1764
Query: 519 LTNEVELRDKRINQFEDEIGILQHKIE--------KEKAIQDQI------TAQNDTLLLE 564
E L ++Q E EI +LQ +++ KE+++Q Q+ AQ D L
Sbjct: 1765 KVGETSL---LLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821
Query: 565 KRKLQEQVIEQEQLIHSNKWTI-SSIQSRVLYMDKENKQLQ---ENSLRLTQQIGFLERI 620
++ Q+Q QE+ + + +++ + + + + +LQ E + RL +++ R
Sbjct: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
Query: 621 IRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQ-------- 672
++++ G+ E + + LA +Q + + E ++ LQ
Sbjct: 1882 VQALEEVLGDLRAE---SREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER 1938
Query: 673 -HEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGK--GLVESFASLQE 729
E E++ ++ +H E+ +E + E L ++++ GK L+E A L
Sbjct: 1939 DQELEALRAESQSSRHQEEAARA-----RAEALQEALGKAHAALQGKEQHLLEQ-AELSR 1992
Query: 730 TEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQDQ 779
+ E + AS + + L + + G I L+ +Q+ Q
Sbjct: 1993 SLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ 2042
Score = 68.9 bits (167), Expect = 2e-11
Identities = 97/508 (19%), Positives = 217/508 (42%), Gaps = 49/508 (9%)
Query: 4 EKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESE 63
EKN E++ K E +L + L ++ + ++L +S+ + ++ L E++
Sbjct: 659 EKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
Query: 64 SKDHFLIAC----DLLQRENSELETKVLKLSQE----FAQLNHFTLGGKTAPSNLITSEN 115
++ L + L RE + LE ++ + ++ QL + + S+L ++
Sbjct: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
Query: 116 TCKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQ 175
E + LE +IQ+ + E + ++ K + E S E +++ ++Q
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERS------QAEQERDAAARQ 832
Query: 176 NRDMKDEEK---EQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEK 232
+ E K EQQ +E+ +LRE+ + + H K
Sbjct: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKW-----------------EKERSWHQQELAK 875
Query: 233 LKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQ-NLDLKQHNSLLQEENIKIKIELK 291
+ + E +L L Q + + + ER Q L Q ++E + + L
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 292 HAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVAD 351
Q++L D+++ L + K QK+KE E + TQ ++Q L+E Q + +A
Sbjct: 936 QTQKELADASQQLERLRQDMK--VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAA 993
Query: 352 AEEKI-------LDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQ 404
+E+ +DLQ+++E + ++ +E++++E + + + +E +
Sbjct: 994 LQEESSSLLQDKMDLQKQVEDLKSQLVAQD--DSQRLVEQEVQEKLRETQEYNRIQKELE 1051
Query: 405 QKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVK 464
+++ L ++ E +++ LQ+ +++ + S + +Q+ + K+L + + VK
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK 1111
Query: 465 SNQ-ELSEKLSKLQQEKEA--LREEYLR 489
+ + + ++L +E EA + E+ LR
Sbjct: 1112 EKEADFLAQEAQLLEELEASHITEQQLR 1139
Score = 60.5 bits (145), Expect = 6e-09
Identities = 108/519 (20%), Positives = 209/519 (40%), Gaps = 60/519 (11%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
Q++ + + + + +E+ L L+ A LK ELQ K + L E+
Sbjct: 1823 QQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV 1882
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFA-QLNHFTLGGKTAPSNLITSENTCKDPE 121
++ + L L+ E+ E E +L L Q+ A Q + + + + ++ K+ +
Sbjct: 1883 QALEEVL---GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939
Query: 122 SNEPILETEIQSRKEE-------TEELCPKLGER------KQKEIPEESVKEGSFPREGQ 168
L E QS + + E L LG+ K++ + E++ S
Sbjct: 1940 QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 169 KEEGSQQNRDMKDEEKEQQLTMKPEEI----VRLREELSHINQSLLQ-------SQSSGD 217
+ S + E+ L ++ EI +R +E++ + Q+L Q Q
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059
Query: 218 SSDDSGAQHPSSG---EKLKYNQQGEVQQ---LHQNLHRLQILCNSAENEL----RYERG 267
+ S AQ EK Q+ E ++ LHQ++ LQ+ E E+ ++
Sbjct: 2060 LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQR 2119
Query: 268 QNLDLKQHN---SLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELE 324
NL+ H+ S ++E+++K+ Q++L A ++K ++L L
Sbjct: 2120 NNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179
Query: 325 VLKHTQSIKSQNN----LQEKLVQEKSKVADAEEKILDLQRKLE--HAHKVCLTDTC-IS 377
+ + S+ S LQ +++ S+ ++++ +R LE H T T +
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELG 2239
Query: 378 EKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQ 437
+ + ++ E + EA+ E+Q R+ L LQ LE+ S+
Sbjct: 2240 SRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEH-----------LQQAVARLEIDRSR 2288
Query: 438 QQSRIQQQEALLKQLENEKRKYD-EHVKSNQELSEKLSK 475
Q Q + L+Q+E E+RK E +++ Q S ++SK
Sbjct: 2289 LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISK 2327
Score = 51.6 bits (122), Expect = 3e-06
Identities = 92/502 (18%), Positives = 208/502 (41%), Gaps = 54/502 (10%)
Query: 268 QNLDLKQHNSLLQEENIKIKIELKHAQQKLLDS-TKMCSSLTAEYKHCQQKIKELELEVL 326
Q L+ + H +E I++K + + +L D T++ + LT K Q + E ++ L
Sbjct: 254 QELEKEAHER--SQELIQLKSQGDLEKAELQDRVTELSALLTQSQK--QNEDYEKMIKAL 309
Query: 327 KHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKI 386
+ T I N+ E + E S +A+E+ L LQ+ ++ +T + E + +
Sbjct: 310 RETVEILETNHT-ELMEHEASLSRNAQEEKLSLQQVIKD-----ITQVMVEEGDNIAQGS 363
Query: 387 --KEATQNEAKVKQQYQEEQQKRKLLY---------QNVDELHRQVRTLQDKENLLEMTC 435
+ + + ++ + Q+ + + L Q V +L +Q+ Q+ NLL+
Sbjct: 364 GHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQH 423
Query: 436 SQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEAL---REEYLRLLK 492
Q + ++ +AL ++L+ + D +L ++ L +E+E L REE + L+
Sbjct: 424 DQWE---EEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE 480
Query: 493 LL----------NVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFE-------D 535
+L NV ++ + QK + Q+ + E E + + E
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS 540
Query: 536 EIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLY 595
E+ L+ +E + + + + + ++ + E ++ K ++ +++ +
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 596 MDKENKQLQENSLRLTQQIGFLERIIRSIHIR-----RGENLKEFPVPKWWHRGKLASLP 650
+ N+ L + + L QQ+ LE +S+ R + N + + + R +
Sbjct: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
Query: 651 PTKKQKEIYSTE----VFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNE 706
T + ++ E ++ ++Q E E + + + +H ++ TT + L E +
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 707 ILPLSNSSFSGKGLVESFASLQ 728
L+ + + LV A+L+
Sbjct: 721 EEVLARAVQEKEALVREKAALE 742
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 93.2 bits (230), Expect = 8e-19
Identities = 161/854 (18%), Positives = 375/854 (43%), Gaps = 111/854 (12%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAE-KALKVESEELQKSKSELICLYNEVHNLP 59
+++++ E+ + ++ERE ++Q+ L+ ++ + LK+ E+ Q+ L L + +
Sbjct: 489 LARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAIL 548
Query: 60 GESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKD 119
ESE+K LQ+E T++L+L + +L ++N KD
Sbjct: 549 TESENK------LRDLQQEAETYRTRILELESSLEK-------------SLQENKNQSKD 589
Query: 120 PESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDM 179
L +++ K + + + E+ + E+ ES+K +K + +Q
Sbjct: 590 -------LAVHLEAEKNKHNKEITVMVEKHKTEL--ESLKHQQDALWTEKLQVLKQQYQT 640
Query: 180 KDE------EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKL 233
+ E E+E++ +K +EI+ + + +N+ L+ + +S + S K
Sbjct: 641 EMEKLREKCEQEKETLLKDKEII-FQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699
Query: 234 KYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLD--LKQH-------NSLLQEENI 284
++ + E+ L +++ + +E + Q +D +K+H L+++
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN 759
Query: 285 KIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKE--LELEVLKHTQSIKSQNN--LQE 340
++++ LK + L + +L A+ K + ++++ +L+V + QS + +E
Sbjct: 760 QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
Query: 341 KLVQEKSKVADAE-EKILDLQRKLE------------HAHKVCLTDTCIS-EKQ--QLEE 384
+L Q + K+ D E E+IL ++ E AHK+ + D EKQ ++E+
Sbjct: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ 879
Query: 385 KIKEATQ-NEAKVKQQYQEEQQKRKLLYQNVD-----------ELHRQVRTLQDKENLLE 432
K+K TQ E+K++ +E++Q +++L + + E+ + L KE+ +
Sbjct: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
Query: 433 MTCSQQQSRIQQQEALLKQLEN---------EKRKYDEHVKSNQELSEKLSKLQQEKEAL 483
+ + +++ + QE +++++ +K+ D+ K +EL +L Q+++
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQF 999
Query: 484 REEYLRLLKL----LNVHVRNYNEKHHQQKVKLQKVKYRLTNEV-ELRDKRINQFEDEIG 538
+ L + + ++ V +Q L +V R N+V + +K++NQ +E+
Sbjct: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059
Query: 539 ILQHKIEKEKAIQDQITAQNDTLLL--EKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYM 596
+ H+I+ ++ Q+ + LL EK ++ +++ ++ T++ +Q ++
Sbjct: 1060 EI-HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
Query: 597 DKENKQLQENSLRLTQQIGFLERIIRSI---HIRRGENLKEFPVPKWWHRGKLASLPPTK 653
L ++ +L + LE + + E L E + + K++ L T
Sbjct: 1119 SAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSEL--TS 1176
Query: 654 KQKEIYSTEVFTSNNAELQHEDESVPEATEKWKH-SEQMETTI------SDILESEVVNE 706
K K + E F S + + ++S+ + + ++K SE++ + ++ L NE
Sbjct: 1177 KLKT--TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNE 1234
Query: 707 ILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVA 766
++ +S+S + + S S + K KEA+ E + E +N++
Sbjct: 1235 LINISSSKTNA---ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNIS 1291
Query: 767 SLKETHGIQEQDQK 780
+ TH ++E++ +
Sbjct: 1292 FQQATHQLEEKENQ 1305
Score = 84.7 bits (208), Expect = 3e-16
Identities = 179/838 (21%), Positives = 338/838 (40%), Gaps = 146/838 (17%)
Query: 14 SKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACD 73
S++ ++QL L EK + E K++LI + NL + E +D ++ +
Sbjct: 314 SEKEALQEQLDERLQELEKIKDLHMAE----KTKLITQLRDAKNLIEQLE-QDKGMVIAE 368
Query: 74 LLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQS 133
++ + LE K +++Q +++ T G+ SE E E L T
Sbjct: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF--EELEKALSTA--- 423
Query: 134 RKEETEELCPKLGERKQKEIP--EESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLT-- 189
++TEE KL ++I E++ +E + + Q+ D+ + E+Q+
Sbjct: 424 --QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
Query: 190 --MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ---- 243
+ +E+ R +EL+ LQ++ A S E LK +Q+ E Q+
Sbjct: 482 QKLHEKELARKEQELT----KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537
Query: 244 --------------------LHQNLH----RLQILCNSAENELRYERGQNLDL------- 272
L Q R+ L +S E L+ + Q+ DL
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 273 -KQHNS--LLQEENIKIKIE-LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKEL---ELEV 325
+HN + E K ++E LKH Q L T+ L +Y+ +K++E E E
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQDALW--TEKLQVLKQQYQTEMEKLREKCEQEKET 655
Query: 326 LKHTQSIKSQNNLQE--KLVQEKSKVADAEEKIL--DLQRKLEHAHKV-----CLTDTCI 376
L + I Q +++E + EK V E + L +L L+ HK+ L D
Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD 715
Query: 377 SEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCS 436
KQ+LE K+ E Q+ +QQ ++ ++ + R + L+D+ N LE+
Sbjct: 716 KMKQELEAKMDE---------QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766
Query: 437 QQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNV 496
++ +++ +A ++ LE + ++ + + Q+ S KL Q + A E+
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEGEL---QQASAKLDVFQSYQSATHEQ---------- 813
Query: 497 HVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDE-----IGILQHKIEKEKAIQ 551
+ + +Q +LQ+ L E L K++ + E + + HKI+ + +Q
Sbjct: 814 -----TKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQ 868
Query: 552 DQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENK--QLQENSLR 609
Q+ QN + + + L + + + +L NK Q++ + ++KEN Q++E +
Sbjct: 869 -QLEKQNSEMEQKVKSLTQ--VYESKLEDGNK---EQEQTKQILVEKENMILQMREGQKK 922
Query: 610 ----LTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPTKKQKEIYSTEVFT 665
LTQ++ E SIHI E +F + KK +++
Sbjct: 923 EIEILTQKLSAKE---DSIHILNEEYETKFKNQE-------------KKMEKV------- 959
Query: 666 SNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNEILPLSNSSFSGKGLVESFA 725
A+ E ++ K +++E T ++ + E L + + G+ ++ +
Sbjct: 960 KQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS 1019
Query: 726 SLQETEEIKSKEAMASSKSPEKSPENLVCSQNSEAGYINVASLKETHGIQEQDQKSEL 783
L E KE + S + N V S + L+E H IQ Q+++ E+
Sbjct: 1020 RL----ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEV 1073
Score = 84.7 bits (208), Expect = 3e-16
Identities = 131/594 (22%), Positives = 261/594 (43%), Gaps = 68/594 (11%)
Query: 1 MSQEKNEMFESEWSKEREREKQLASGLDT----AEKALKVESEELQKSKSELICLYNEVH 56
M +K++M + E + E E + Q A ++ +K +++ES +E++ YN+
Sbjct: 1502 MEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES------LNEVLKNYNQQK 1555
Query: 57 NLPGES--ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSE 114
++ + + HF + E E K+L L + + +T L
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL---ETKKKELEHVN 1612
Query: 115 NTCKDPESNEPILETEIQSRKEETEELCPKLGERKQK-EIPEESVKEGSFPREGQKEEGS 173
+ K E LE ++S E KL E K+K E ++K+ + +KEE
Sbjct: 1613 LSVKSKEEELKALEDRLES------ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 174 QQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKL 233
++ + E +L + E+ L E+L + S ++ S+ + A E+
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYT----EQE 1722
Query: 234 KYNQQGEVQQLHQNLHRLQILC-NSAENELRYER-GQNLD--LKQHNSLLQEENIKIKIE 289
+ + QG VQ+ ++ ++ +L N E E +R GQ + + H + + ++ I+
Sbjct: 1723 EADSQGCVQKTYEE--KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL-IK 1779
Query: 290 LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKV 349
L+HA+ K + M L E ++K K+ L V +H + +NN+Q K Q V
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEEL---EEKNKKYSLIVAQHVEKEGGKNNIQAK--QNLENV 1834
Query: 350 ADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKL 409
D D+Q+ L+ C Q LE+KIKE + K+ ++ E ++
Sbjct: 1835 FD------DVQKTLQEKELTC---------QILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
Query: 410 LYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHV----KS 465
Y+ + L + + E L E T + +S + Q + LL +E + + + +
Sbjct: 1880 KYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK-LLSNMEAQHNDLEFKLAGAERE 1938
Query: 466 NQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVEL 525
Q+L +++ +LQ++ LR+E+ + L++L + Y+++ ++K+K ++ L + L
Sbjct: 1939 KQKLGKEIVRLQKDLRMLRKEHQQELEILK---KEYDQE-REEKIKQEQEDLELKHNSTL 1994
Query: 526 RDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLI 579
+ + + +F ++ Q + E E I++ I N +E L+ E QL+
Sbjct: 1995 K-QLMREFNTQLA--QKEQELEMTIKETI---NKAQEVEAELLESHQEETNQLL 2042
Score = 77.8 bits (190), Expect = 4e-14
Identities = 166/790 (21%), Positives = 345/790 (43%), Gaps = 120/790 (15%)
Query: 18 EREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKD----------- 66
E+E + + +K +++ +++L +K + I + NE + +++ K
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLS-AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEM 966
Query: 67 HFLIACDLLQRE---NSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESN 123
+ LL +E ELE L+LSQ+ Q N L + A +N + E+N
Sbjct: 967 QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKML--EMAQANSAGISDAVSRLETN 1024
Query: 124 EPILETEIQSRKEETEELCPKLGERKQKEIPEE-SVKEGSFPREGQKEEGSQQNRDMKDE 182
+ KE+ E L E ++E+ + S+ E Q+ E Q+ +++ +
Sbjct: 1025 Q----------KEQIESLT----EVHRRELNDVISIWEKKL---NQQAEELQEIHEIQLQ 1067
Query: 183 EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
EKEQ++ ++I+ E +N+ + + G D + + E+LK + V
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE---LQEQLK-QKSAHVN 1123
Query: 243 QLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTK 302
L Q+ +L+ E +L N LK+ N+ LQE+ +++K+ + ++K+
Sbjct: 1124 SLAQDETKLKAHLEKLEVDL------NKSLKE-NTFLQEQLVELKMLAEEDKRKV----- 1171
Query: 303 MCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILD--LQ 360
S LT++ K ++ + L+ K +S++ ++ +KL +E + D K + L+
Sbjct: 1172 --SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
Query: 361 RKLEHAHKVCLTDT-----CISEKQQLEEKIKEA------TQNEAKVK-QQYQEEQQKRK 408
K + + T IS Q K+KEA T +E + + +Q EEQ
Sbjct: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLN 1289
Query: 409 LLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEH----VK 464
+ +Q + L++KEN ++ + +S + ++EAL K+ N+++ E +
Sbjct: 1290 ISFQ------QATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQ 1343
Query: 465 SNQELSEKLSKLQQEKEALREEYLRLLKL------LNVHVRN-------------YNEKH 505
+ELSE ++ + KE L+E+ + + L LNV ++N +++
Sbjct: 1344 LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY 1403
Query: 506 HQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKI-EKEKAIQDQITAQNDTLLLE 564
++K +L L+ +V+ K +++ +K E +K Q + T +T+
Sbjct: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV--- 1460
Query: 565 KRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENK-------QLQENSLRLTQQIGFL 617
++LQ Q+ + + + I+ ++ +D++NK +++++ ++ ++ L
Sbjct: 1461 -KELQIQLELKSKEAYEKDEQINLLKEE---LDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 618 ERIIRSIHIRRGENLKEFPVPKWWHRGKLAS-LPPTKKQKEIYSTEVFTSNNAELQHEDE 676
E ++S R E L++ K L L +QK+I E+ +LQH E
Sbjct: 1517 ETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV----QKLQHFQE 1571
Query: 677 SVPEATEKWKHSEQMETTISD---ILESEVVNEILPLSNSSFSGKGLVESFASLQETEEI 733
E + K +E+ T+ + +++E+ + L + + S K E +L++ E
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 734 KSKEAMASSK 743
+S +A K
Sbjct: 1632 ESAAKLAELK 1641
Score = 71.6 bits (174), Expect = 3e-12
Identities = 138/654 (21%), Positives = 256/654 (39%), Gaps = 127/654 (19%)
Query: 156 ESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKP--EEIVRLREELSHINQSLLQSQ 213
E + EG+ RE + Q ++ E L P E + R + S + S +S
Sbjct: 44 EQLDEGTPNRESGDTQSFAQKLQLRVPSVES-LFRSPIKESLFRSSSKESLVRTSSRESL 102
Query: 214 S-----SGDSSDDSGAQHPSSGEKLKYNQQG-EVQQLHQNLHRLQILCNSAENELRYERG 267
+ S +S D + S E L N +QL Q L R+ E L RG
Sbjct: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRM-------ERSLSSYRG 155
Query: 268 QNLDLKQHNSLLQEENIKIKIELKHAQQKLL----------------------------- 298
+ +L +LQ E K++ L +Q K L
Sbjct: 156 KYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLE 215
Query: 299 DSTKMCSSLTAEYKHCQQKIKE--LELEVLKHTQSIKSQNNL----------QEKLVQEK 346
+ + S L + +Q+++ + ++VLK ++ Q + E +V++
Sbjct: 216 EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDG 275
Query: 347 SKVADAE---------EKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVK 397
+ V E E +L ++ +HK T SEK+ L+E++ E Q K+K
Sbjct: 276 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCT-LLTSEKEALQEQLDERLQELEKIK 334
Query: 398 QQYQEEQQKRKLLYQNVDELHRQV------------RTLQDKENLLEMTCSQQQSRIQQQ 445
+ E+ K ++ L Q+ R + + + E +Q +SRI+Q
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
Query: 446 EALLKQLENEKRK-----------------------------YDEHVKSNQELS-EKLSK 475
++L +K K DE +K+ ++ S E+
Sbjct: 395 TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERIS 454
Query: 476 LQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFED 535
LQQE +++E + ++K + +K H++ +L + + LT +++ R++ +F++
Sbjct: 455 LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELARKEQELTKKLQTRER---EFQE 509
Query: 536 EIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVI--EQEQLIHSNKWTISSIQSRV 593
++ + K + E Q Q ++L LE+ +LQ++ I E E + + + ++R+
Sbjct: 510 QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRI 569
Query: 594 LYMDKE-NKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPKWWHRGKLASLPPT 652
L ++ K LQEN + LE + ++ KE V H+ +L SL
Sbjct: 570 LELESSLEKSLQENKNQSKDLAVHLE-------AEKNKHNKEITVMVEKHKTELESL--- 619
Query: 653 KKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDILESEVVNE 706
K Q++ TE + Q E E + E E+ K + + I E +NE
Sbjct: 620 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Score = 67.4 bits (163), Expect = 5e-11
Identities = 135/663 (20%), Positives = 281/663 (42%), Gaps = 76/663 (11%)
Query: 4 EKNEMF-ESEWSKEREREKQLASGLDTAEKALKVESEELQ-------KSKSELICLYNEV 55
EK EM E W KE E KQ + L+ ++ LK +S + K K+ L L ++
Sbjct: 1086 EKEEMNKEITWLKE-EGVKQDTT-LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
Query: 56 HNLPGESESKDHFLIACDLLQREN----SELETKVLKLSQEFAQLNHFTLGGKTAPSNLI 111
+ E+ L+ +L E+ SEL +K+ +EF L
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS------------- 1190
Query: 112 TSENTCKDPESNEPILETEIQSRKEETE-----ELCPKLGERKQKEIPEESVKEGSFPRE 166
+SN+ + + ++ +K E ++C K E + E + S
Sbjct: 1191 ------SHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTN 1244
Query: 167 GQKEEGSQ-QNRDMKDEE----KEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDD 221
S Q+R K +E K ++ ++ +L EE + +N S Q+ + ++
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304
Query: 222 SGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQE 281
+ E L ++ +Q+ N + S +L+ E +N++ +L++E
Sbjct: 1305 QIKSMKADIESLVTEKEA-LQKEGGNQQQAASEKESCITQLKKELSENINAV---TLMKE 1360
Query: 282 ENIKIKIELKHAQQKLLD-STKMCSSLTAEYKHC-----QQKIKELELEVLKHTQSIKSQ 335
E + K+E+ ++L D + ++ +S++ K +++ E + E+L Q + +
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420
Query: 336 -NNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQ-QLEEKIKEATQNE 393
+ L ++ + +V D K + ++K + + + E Q QLE K KEA + +
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQS--RFTQHQNTVKELQIQLELKSKEAYEKD 1478
Query: 394 AKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLE 453
++ +E Q+ K E+ ++ KE+ LE Q +RI + E + Q
Sbjct: 1479 EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKT 1538
Query: 454 NEKRKYDEHVKS-NQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKL 512
E +E +K+ NQ+ + +L Q+ + +E L N ++ ++ + L
Sbjct: 1539 IEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE--------LGEEKDNRVKEAEEKILTL 1590
Query: 513 QKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLE-KRKLQEQ 571
+ Y + E+E + K + + + K E+ KA++D++ +++ L E KRK +++
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSV---KSKEEELKALEDRLESESAAKLAELKRKAEQK 1647
Query: 572 V--IEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRG 629
+ I+++ L + + ++ + N +LQE +++ LE ++S+ +
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE----REVHILEEKLKSVESSQS 1703
Query: 630 ENL 632
E L
Sbjct: 1704 ETL 1706
Score = 44.7 bits (104), Expect = 3e-04
Identities = 79/354 (22%), Positives = 153/354 (43%), Gaps = 44/354 (12%)
Query: 410 LYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKY--------DE 461
L N D L+++ L + +E + S + + + + L+ EK+K D+
Sbjct: 127 LVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 462 HVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTN 521
++ EL E+L QQ K+ L+EE+ L+ + ++ Q +V L +K RL N
Sbjct: 185 SLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVL-----QTQVSL--LKQRLRN 237
Query: 522 EVELRD--KRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLI 579
D K + Q E + + + E + ++ T + LQ++V QE L+
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPES--DGEPVVEDGTSVKTLETLQQRVKRQENLL 295
Query: 580 HSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENLKEFPVPK 639
K TI S + + + E + LQE +L +++ LE+ I+ +H+ L
Sbjct: 296 KRCKETIQSHKEQCTLLTSEKEALQE---QLDERLQELEK-IKDLHMAEKTKLIT----- 346
Query: 640 WWHRGKLASLPPTKKQKEIYSTEVFTSNNAELQHEDESVPEATEKWKHSEQMETTISDIL 699
R + ++ K + E + L+ ++E + + + K QM T ++
Sbjct: 347 -QLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK---QMTTQGEELR 402
Query: 700 ESEVVNEILPLSNSSFSGKGLVESFASLQETEEIKSK---EAMASSKSPEKSPE 750
E + +E ++F + L ++ ++ Q+TEE + K E K+ EK+ E
Sbjct: 403 EQKEKSE-----RAAF--EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE 449
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 92.4 bits (228), Expect = 1e-18
Identities = 90/506 (17%), Positives = 233/506 (46%), Gaps = 53/506 (10%)
Query: 147 ERKQKEI-----PEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREE 201
+ K+K+I PE + G E +++ Q ++ E + Q T++ + +
Sbjct: 72 DTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQ 131
Query: 202 LSHINQSLLQSQSSGDSSDDSGAQHPS--------------SGEKLKYNQQGEVQQLHQN 247
++ Q G++ D H S + +K K ++ E ++
Sbjct: 132 MALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERD 191
Query: 248 LHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMC--S 305
L++ N+ +E E+ N L++ L++ E +I++ +K ++KL + +
Sbjct: 192 ALSLELYRNTITDEELKEK--NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQ 249
Query: 306 SLTAEYKHCQQKIKELELEVLKHTQSIKSQNNL----QEKLVQEKSKVADAEEKILDLQR 361
L AE H ++++ + ++ + + N L +EK+ +++ K+ + EEKI + +
Sbjct: 250 QLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEE 309
Query: 362 KLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQV 421
K+ EK + +E++ + E K+++Q + +K + + + +++H Q
Sbjct: 310 KIREQE----------EKMRRQEEMM--WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357
Query: 422 RTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKE 481
+ + +E E ++Q + Q+QEA + + E + R+ +E ++ +E+ ++ + E+E
Sbjct: 358 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE 417
Query: 482 ALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQ 541
E ++ +R EK +Q+ K+++ + ++ + E+ ++ + ++ G +
Sbjct: 418 EKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477
Query: 542 HKIEKEKAIQDQITAQNDTLLLEKRKLQEQ---VIEQEQLIHSNKWTI-----------S 587
+ K + ++++ Q + + +++K++EQ + EQE+++ + +
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 537
Query: 588 SIQSRVLYMDKENKQLQENSLRLTQQ 613
+Q + M ++ ++++E +RL QQ
Sbjct: 538 KMQEQEEKMRRQEEKMREQEVRLRQQ 563
Score = 79.7 bits (195), Expect = 1e-14
Identities = 81/454 (17%), Positives = 203/454 (44%), Gaps = 49/454 (10%)
Query: 13 WSKEREREKQLASGLDTAEKALKVESEELQKSKSEL-ICLYNEVHNLPGESESKDHFLIA 71
W E E+ L S + T +K EEL K + L + LY E
Sbjct: 159 WKFAGELEQAL-SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 217
Query: 72 CDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEI 131
L++ E SE++ V +L ++ + P + +E E + ++
Sbjct: 218 LQLVESEKSEIQLNVKELKRKLERAKLLL------PQQQLQAEADHLGKELQS--VSAKL 269
Query: 132 QSRKEETEELCPKLGERKQKEI--PEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLT 189
Q++ EE E L +L +++++++ EE ++E + Q+E+ +Q M+ +E+ +
Sbjct: 270 QAQVEENE-LWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR--RQEEMMW 326
Query: 190 MKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLH 249
K E++ R E + + + + + + Q E+ K +Q + Q+ +
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 386
Query: 250 RLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTA 309
R + E ++R + ++QE+ K + ++K+ + +
Sbjct: 387 RQEEKIREQEEKIR----------EQEEMMQEQEEK----MGEQEEKMWEQEEEMQEQEE 432
Query: 310 EYKHCQQKIKELELEVLKHTQSIKSQNNL----QEKLVQEKSKVADAEEKILDLQRKLEH 365
+ + ++KI+E E ++ + + I+ Q + +EK+ +++ K+ + E K+ + + K+
Sbjct: 433 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
Query: 366 AHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQ 425
+++++ E+ K+ + E K+++Q + Q++ + +++ +++ Q +Q
Sbjct: 493 ------------QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 540
Query: 426 DKENLLEMTCSQQQSRIQQQEALLKQLENEKRKY 459
++E + +Q+ ++++QE L+Q E + +++
Sbjct: 541 EQEEKMR----RQEEKMREQEVRLRQQEEKMQEH 570
Score = 76.6 bits (187), Expect = 8e-14
Identities = 67/358 (18%), Positives = 172/358 (48%), Gaps = 28/358 (7%)
Query: 231 EKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYER-GQNLDLKQHNSLLQEENIKIKIE 289
E K Q V++L + L R ++L + + + G+ L Q E ++
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 281
Query: 290 LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNL----QEKLVQE 345
L Q++ + + + + ++KI+E E ++ + + ++ Q + +EK+ ++
Sbjct: 282 LNQQQEEKMWRQE------EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 335
Query: 346 KSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQN----------EAK 395
+ + + EEKI +L+ K+ K+ + EK+Q EEKI+E + E K
Sbjct: 336 EEMMWEKEEKIRELEEKMHEQEKIREQE----EKRQEEEKIREQEKRQEQEAKMWRQEEK 391
Query: 396 VKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLL---EMTCSQQQSRIQQQEALLKQL 452
+++Q ++ +++ +++ + +++ Q + ++E + E +Q+ +I++QE +++
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 453 ENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKL 512
E + R+ +E ++ +E + E+EA +E ++ +R +K +Q+ K+
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI 511
Query: 513 QKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQE 570
++ + + + E ++ + ++ +Q + EK + ++++ Q L ++ K+QE
Sbjct: 512 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 73.9 bits (180), Expect = 5e-13
Identities = 61/363 (16%), Positives = 172/363 (47%), Gaps = 26/363 (7%)
Query: 166 EGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQ 225
E +K E +++K + + +L + +++ + L QS+ + ++ +
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 281
Query: 226 HPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELR------YERGQNLDLKQHNSLL 279
E+ + Q+ ++Q+ + + + E ++R +E+ + + ++
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 341
Query: 280 QEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQ 339
+EE I+ E H Q+K+ + + E Q+K +E E ++ + + I+ Q +
Sbjct: 342 KEEKIRELEEKMHEQEKIREQEEKRQE--EEKIREQEKRQEQEAKMWRQEEKIREQ---E 396
Query: 340 EKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQ 399
EK+ +++ + + EEK+ + + K+ + E Q+ EEK++ + E K+++Q
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEE---------EMQEQEEKMR---RQEEKIREQ 444
Query: 400 YQEEQQKRKLLYQNVDELHRQVRTLQDKENLL---EMTCSQQQSRIQQQEALLKQLENEK 456
++ +++ + + + + + Q + ++E + E +Q+ ++++QE +++ E +
Sbjct: 445 EKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504
Query: 457 RKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVK 516
R+ +E ++ +E+ ++ + E+E E ++ +R EK +Q+V+L++ +
Sbjct: 505 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQE 564
Query: 517 YRL 519
++
Sbjct: 565 EKM 567
Score = 70.9 bits (172), Expect = 4e-12
Identities = 79/403 (19%), Positives = 187/403 (46%), Gaps = 48/403 (11%)
Query: 3 QEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGES 62
QEK ++ ESE S+ + K+L L+ A+ L + ++LQ +E L E+ ++ +
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERAK--LLLPQQQLQ---AEADHLGKELQSVSAKL 269
Query: 63 ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPES 122
+++ + +L R N + E K+ + ++ + K E K
Sbjct: 270 QAQ---VEENELWNRLNQQQEEKMWRQEEKIQEREE-----KIQEQEEKIREQEEKMRRQ 321
Query: 123 NEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDE 182
E + E E + R++E E + K E K +E+ E+ ++ + +K + ++ R+ +
Sbjct: 322 EEMMWEKEEKMRRQE-EMMWEK--EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 378
Query: 183 EKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
++++ + EE +R +EE + ++Q Q + G Q E+ + Q+ E+Q
Sbjct: 379 QEQEAKMWRQEEKIREQEEKIREQEEMMQEQ-----EEKMGEQ-----EEKMWEQEEEMQ 428
Query: 243 QLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTK 302
+ + + R + E ++ R Q +++ ++QE+ K + + K+ +
Sbjct: 429 EQEEKMRRQEEKIREQEKKI---REQEEKIREQEEMMQEQEEK----MGEQEGKMCEQEA 481
Query: 303 MCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRK 362
+ + ++KI+E E ++ + + I+ Q +E + +++ K+ + EEK+ + + K
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ---EEMMQEQEEKMWEQEEKMCEQEEK 538
Query: 363 LEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQ 405
++ + + ++ EEK++E E +++QQ ++ Q+
Sbjct: 539 MQEQEE---------KMRRQEEKMRE---QEVRLRQQEEKMQE 569
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 92.4 bits (228), Expect = 1e-18
Identities = 128/631 (20%), Positives = 263/631 (41%), Gaps = 57/631 (9%)
Query: 8 MFESEWSKEREREKQLASGLDTAEKALKVESEELQKS-------KSELICLYNEVHNLPG 60
M E E K + + + ++ EK L EL+++ +SEL C + N
Sbjct: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE 1461
Query: 61 ESESKDHFLIACDL----LQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENT 116
+ L+ + L+R E ++K Q QL K + I E
Sbjct: 1462 KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ---QLRSLQADAKDLEQHKIKQEEI 1518
Query: 117 CKDPESNEPILETEIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGSQQN 176
K+ +++ Q ++ E+L +L ++ QK+I E + ++ E Q
Sbjct: 1519 LKEINKIVAAKDSDFQCLSKKKEKLTEEL-QKLQKDIEMAERNEDHHLQVLKESEVLLQA 1577
Query: 177 RDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYN 236
+ + E+ + Q+T + +E+ L +L H + L Q S + + GE
Sbjct: 1578 KRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTE 1637
Query: 237 QQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKI--------KI 288
+ ++++ L L ++ ER L L + +EEN+++ K
Sbjct: 1638 KCNHIREVKSLLEELSFQKGELNVQIS-ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 1696
Query: 289 ELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSK 348
ELK+ L L ++ Q++ ELE + + NLQ+ Q+K +
Sbjct: 1697 ELKNILDMLQLENHELQGLKLQH---DQRVSELEKTQVAVLEEKLELENLQQISQQQKGE 1753
Query: 349 VADAEEKILDLQRKLE------HAHKVCLTDTCIS-EKQQLEEKIKEATQNEAKVKQQYQ 401
+ ++ + +R++E A + C+ C+S EK+ L+EK + A+ K+
Sbjct: 1754 IEWQKQLLERDKREIERMTAESRALQSCV--ECLSKEKEDLQEKCDIWEKKLAQTKRVLA 1811
Query: 402 EEQQKRKLLYQNVDELHRQVRTLQ------DKENL-LEMTCSQQQSRIQQQEALLKQLEN 454
++ K+ N+++L VR LQ +++ L L S Q ++Q++ + L+
Sbjct: 1812 AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE 1871
Query: 455 EKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQK 514
E +H+ + L + ++ L E RL K ++ + + +++ K Q+
Sbjct: 1872 ELANVQDHLNL---AKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQ 1928
Query: 515 VKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIE 574
++ L NE+E E+++ ++Q ++ ++ +Q + ++ L K L+EQ +
Sbjct: 1929 LQV-LQNEIE---------ENKLKLVQQEMMFQR-LQKERESEESKLETSKVTLKEQQHQ 1977
Query: 575 QEQLIHSNKWTISSIQSRVLYMDKENKQLQE 605
E+ + K + + S+VL ++ + LQE
Sbjct: 1978 LEKELTDQKSKLDQVLSKVLAAEERVRTLQE 2008
Score = 80.1 bits (196), Expect = 7e-15
Identities = 118/547 (21%), Positives = 242/547 (44%), Gaps = 60/547 (10%)
Query: 130 EIQSRKEETEELCPKLGERKQKEIPEESVKEGSFPREGQKEEGS---QQNRDMKDEEKEQ 186
E+Q K + ++ +L E+ Q + EE ++ + + Q+++G Q+ +D+ + +
Sbjct: 1711 ELQGLKLQHDQRVSEL-EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE 1769
Query: 187 QLTMKP-----------EEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKY 235
++T + +E L+E+ + L Q++ +++++ S+ EKL+
Sbjct: 1770 RMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLEL 1829
Query: 236 NQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQ 295
N V++L Q L +L S N++ + Q + ++ + LQEE ++ L A+Q
Sbjct: 1830 N----VRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQ 1885
Query: 296 KLLDSTKMCSSLTAEYKHCQQKIKEL--ELEVLKHTQSIKSQ--NNLQEKLVQEKSKVAD 351
LL +TK L +E Q+ I E E + + K Q LQ ++ + K K+
Sbjct: 1886 DLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQ 1945
Query: 352 AEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLY 411
E LQ++ E SE+ +LE + + +++++ +++ K +
Sbjct: 1946 QEMMFQRLQKERE------------SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVL 1993
Query: 412 QNVDELHRQVRTLQDKE---NLLEMTCSQQQSRIQQQ---------EALLKQLENEKRKY 459
V +VRTLQ++E LE T SQ + ++ ++ E L Q E + +
Sbjct: 1994 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
Query: 460 DEHVKSNQELSEKLSKLQQE---KEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVK 516
D + NQ L+E+ +Q KEAL+ + +L K L + + N ++ ++ V
Sbjct: 2054 DFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNL-LEQKQENSCIQKEMATIELVA 2112
Query: 517 YRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQ- 575
K +NQ + E L+ ++ +K ++ + +D + K ++++++
Sbjct: 2113 QDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSL 2172
Query: 576 ---EQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERI-IRSIHIR---- 627
Q + + +I R ++ E + L+EN + F E++ +HI
Sbjct: 2173 KNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHW 2232
Query: 628 RGENLKE 634
RGE L+E
Sbjct: 2233 RGEALRE 2239
Score = 67.4 bits (163), Expect = 5e-11
Identities = 177/782 (22%), Positives = 321/782 (41%), Gaps = 106/782 (13%)
Query: 2 SQEKNEMFESEWSKERER-EKQLASGLDTAEKALKVESEELQ--KSKSELICLYNEVHNL 58
+Q++ E FE +E ER E+ L + E+ ++ L+ K++ +L E L
Sbjct: 257 TQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAML 316
Query: 59 PGES--ESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSE-- 114
+S E K +LL+++ EL K + +L + + K P N SE
Sbjct: 317 QKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYA 376
Query: 115 NTCKDPESNEPILETEIQSRKEETEELCPKLGERKQ--KEIPEESVKEGSFPREGQKEEG 172
K P+ + I ++ + TE + Q K P+E ++ G
Sbjct: 377 EIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
Query: 173 SQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEK 232
+Q E+KE++++ + L +E+ Q +L++ + Q + +
Sbjct: 437 TQL------EDKEKKISAAQTRLSELHDEIEKAEQQILRAT-------EEFKQLEEAIQL 483
Query: 233 LKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKH 292
K ++ G+ Q RLQ++ N+LR E LDL+ LQ E K K E+
Sbjct: 484 KKISEAGKDLLYKQLSGRLQLV-----NKLRQEA---LDLE-----LQME--KQKQEIAG 528
Query: 293 AQQKLLDSTKMCSSLTA-EYKHCQQKI----KELELEVLKHTQSIKSQNNLQEKLVQEKS 347
Q+++ D SL + + KH K KE +L+++ K L+ +L + S
Sbjct: 529 KQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMN-----KQYQQLESRLDEILS 583
Query: 348 KVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKR 407
++A E+I DL+ +L ++ + K+ LE I + +K Q + Q
Sbjct: 584 RIAKETEEIKDLEEQLTEG-QIAANEAL---KKDLEGVISGLQEYLGTIKGQATQAQN-- 637
Query: 408 KLLYQNVDELHRQVRTLQD-KENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSN 466
+ R L+D KE LL+ +Q R Q E + EN +++ E +
Sbjct: 638 ------------ECRKLRDEKETLLQRLTEVEQER-DQLEIVAMDAENMRKELAELESAL 684
Query: 467 QELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTN----- 521
QE E + LQQ + L L LN+ + + +Q K +L+KV RLT
Sbjct: 685 QEQHEVNASLQQTQGDLSAYEAELEARLNLR----DAEANQLKEELEKVT-RLTQLEQSA 739
Query: 522 -EVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIH 580
+ EL +R ++ +G Q EKE+ +N L + + LQ+ +Q +
Sbjct: 740 LQAELEKER-QALKNALGKAQFSEEKEQ--------ENSELHAKLKHLQDDNNLLKQQLK 790
Query: 581 SNKWTISSIQSRVLYMDKENKQLQENSLRLTQQIGFLERIIRSIHIRRGENL-------K 633
+ ++ + ++ ++ ++ E LR ++G E I S G++L
Sbjct: 791 DFQNHLNHVVDGLVRPEEVAARVDE--LRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFS 848
Query: 634 EFPVPKWWHRGKLASLPPTKKQKEI-YSTEVFTSNNAELQHEDESVPEAT---EKWKHS- 688
E W R + A + K Q+E+ E + E + E EA +K +H
Sbjct: 849 EILARSKWERDE-AQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEA 907
Query: 689 --EQMETTISDILES-EVVNEILPLSNSSFSGKGLVESFASLQETEEIKSKEAMASSKSP 745
+QME I + E+ + + EI L++ + E L + E++ K+ + +KS
Sbjct: 908 RIQQMENEIHYLQENLKSMEEIQGLTDLQLQ-EADEEKERILAQLRELEKKKKLEDAKSQ 966
Query: 746 EK 747
E+
Sbjct: 967 EQ 968
Score = 57.4 bits (137), Expect = 5e-08
Identities = 74/332 (22%), Positives = 140/332 (42%), Gaps = 59/332 (17%)
Query: 255 CNSAENE-LRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKH 313
CN E+ L E + D+ QH + E ++ + +++++ + L E K
Sbjct: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKS 1372
Query: 314 CQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKV---- 369
+ +++EL V K Q + E L+ E L++++ L+H +
Sbjct: 1373 LECEVEELHRTVQKRQQQKDFIDGNVESLMTE-----------LEIEKSLKHHEDIVDEI 1421
Query: 370 -CLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQ--------KRKLLYQNVDELHRQ 420
C+ T + + +L E + + E+++ ++ + KR LL D +
Sbjct: 1422 ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE 1481
Query: 421 VRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKS-NQELSEKLSKLQ-- 477
R + NL++ + QQ R Q +A K LE K K +E +K N+ ++ K S Q
Sbjct: 1482 RRAQETAVNLVK---ADQQLRSLQADA--KDLEQHKIKQEEILKEINKIVAAKDSDFQCL 1536
Query: 478 -QEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDE 536
++KE L EE +L K ++ + NE HH Q +K +V
Sbjct: 1537 SKKKEKLTEELQKLQK--DIEMAERNEDHHLQVLKESEV--------------------- 1573
Query: 537 IGILQHKIEKEKAIQDQITAQNDTLLLEKRKL 568
+LQ K + + ++ Q+T+Q + + R+L
Sbjct: 1574 --LLQAKRAELEKLKSQVTSQQQEMAVLDRQL 1603
Score = 52.4 bits (124), Expect = 2e-06
Identities = 109/480 (22%), Positives = 187/480 (38%), Gaps = 86/480 (17%)
Query: 31 EKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENSELETKVLKLS 90
+ L E LQK SE N + E E+K L +LQ E E + K+++
Sbjct: 1894 QDVLLSEQTRLQKDISEWA---NRFEDCQKEEETKQQQL---QVLQNEIEENKLKLVQQE 1947
Query: 91 QEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGERKQ 150
F +L K+ ES E LET + KE+ +L +L ++K
Sbjct: 1948 MMFQRLQ--------------------KERESEESKLETSKVTLKEQQHQLEKELTDQKS 1987
Query: 151 K--EIPEESVKEGSFPREGQKEEG---------SQQNRDMKDEEKEQQLTMKPEEIVRLR 199
K ++ + + R Q+EE SQ R + E+EQQL K E++ L+
Sbjct: 1988 KLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL--SEREQQLVEKSGELLALQ 2045
Query: 200 EELSHINQ--SLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNS 257
+E + SLL++Q + + Q S E LK + QL +NL
Sbjct: 2046 KEADSMRADFSLLRNQFLTERK-KAEKQVASLKEALKIQR----SQLEKNL--------- 2091
Query: 258 AENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQK 317
L+ KQ NS +Q+E I++ + ++ K + + EY +++
Sbjct: 2092 ------------LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQ 2139
Query: 318 I---KELE---LEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCL 371
+ K+LE +E+ +++KS+ E K+ E DL+ LE
Sbjct: 2140 MANQKDLERRQMEISDAMRTLKSEVK-DEIRTSLKNLNQFLPELPADLEAILER------ 2192
Query: 372 TDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLL 431
+ E + L+E + T NE +++ Q + + L ++R +D+
Sbjct: 2193 NENLEGELESLKENL-PFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ 2251
Query: 432 EMTCSQQQSRI-----QQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREE 486
C +Q+ + +Q E L L + E V S S L Q + +L E+
Sbjct: 2252 LRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTED 2311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.327
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,393,899
Number of Sequences: 37866
Number of extensions: 1365843
Number of successful extensions: 23550
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 467
Number of HSP's successfully gapped in prelim test: 1334
Number of HSP's that attempted gapping in prelim test: 8683
Number of HSP's gapped (non-prelim): 7218
length of query: 783
length of database: 18,247,518
effective HSP length: 110
effective length of query: 673
effective length of database: 14,082,258
effective search space: 9477359634
effective search space used: 9477359634
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.