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Search of human proteins with 38327632
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38327632 discoidin domain receptor family, member 1 isoform
b [Homo sapiens]
(876 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38327632 discoidin domain receptor family, member 1 isoform b... 1814 0.0
gi|83977450 discoidin domain receptor family, member 1 isoform a... 1795 0.0
gi|83977452 discoidin domain receptor family, member 1 isoform c... 1789 0.0
gi|62420886 discoidin domain receptor family, member 2 precursor... 921 0.0
gi|62420884 discoidin domain receptor family, member 2 precursor... 921 0.0
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 247 3e-65
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 247 3e-65
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 241 3e-63
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 238 2e-62
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 238 2e-62
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 238 2e-62
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 231 2e-60
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 226 9e-59
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 208 2e-53
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 199 9e-51
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 199 9e-51
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 198 2e-50
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 197 3e-50
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 194 2e-49
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 193 7e-49
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 193 7e-49
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 192 1e-48
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 189 7e-48
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 189 7e-48
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 189 7e-48
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 189 7e-48
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 189 7e-48
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 188 2e-47
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 188 2e-47
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 188 2e-47
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 1814 bits (4698), Expect = 0.0
Identities = 876/876 (100%), Positives = 876/876 (100%)
Query: 1 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 60
MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
Sbjct: 1 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 60
Query: 61 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 120
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
Sbjct: 61 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 120
Query: 121 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 180
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
Sbjct: 121 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 180
Query: 181 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 240
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
Sbjct: 181 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 240
Query: 241 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 300
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
Sbjct: 241 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 300
Query: 301 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 360
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
Sbjct: 301 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 360
Query: 361 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 420
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
Sbjct: 361 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 420
Query: 421 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 480
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
Sbjct: 421 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 480
Query: 481 PPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTL 540
PPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTL
Sbjct: 481 PPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTL 540
Query: 541 QGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS 600
QGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS
Sbjct: 541 QGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS 600
Query: 601 LDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL 660
LDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL
Sbjct: 601 LDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL 660
Query: 661 CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL 720
CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL
Sbjct: 661 CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL 720
Query: 721 ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM 780
ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM
Sbjct: 721 ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM 780
Query: 781 GKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACP 840
GKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACP
Sbjct: 781 GKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACP 840
Query: 841 QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 876
QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV
Sbjct: 841 QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 876
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 1795 bits (4650), Expect = 0.0
Identities = 876/913 (95%), Positives = 876/913 (95%), Gaps = 37/913 (4%)
Query: 1 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 60
MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
Sbjct: 1 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 60
Query: 61 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 120
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
Sbjct: 61 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 120
Query: 121 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 180
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
Sbjct: 121 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 180
Query: 181 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 240
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
Sbjct: 181 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 240
Query: 241 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 300
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
Sbjct: 241 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 300
Query: 301 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 360
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
Sbjct: 301 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 360
Query: 361 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 420
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
Sbjct: 361 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 420
Query: 421 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 480
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
Sbjct: 421 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 480
Query: 481 PPPYQEPRPRGNPPHSAPCVPNGSA----------------------------------- 505
PPPYQEPRPRGNPPHSAPCVPNGSA
Sbjct: 481 PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT 540
Query: 506 --YSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP 563
YSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP
Sbjct: 541 QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP 600
Query: 564 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 623
PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD
Sbjct: 601 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 660
Query: 624 ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 683
ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED
Sbjct: 661 ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 720
Query: 684 KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI 743
KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI
Sbjct: 721 KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI 780
Query: 744 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC 803
KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC
Sbjct: 781 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC 840
Query: 804 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 863
RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
Sbjct: 841 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 900
Query: 864 LHRFLAEDALNTV 876
LHRFLAEDALNTV
Sbjct: 901 LHRFLAEDALNTV 913
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 1789 bits (4633), Expect = 0.0
Identities = 876/919 (95%), Positives = 876/919 (95%), Gaps = 43/919 (4%)
Query: 1 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 60
MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
Sbjct: 1 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 60
Query: 61 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 120
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
Sbjct: 61 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 120
Query: 121 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 180
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
Sbjct: 121 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 180
Query: 181 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 240
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
Sbjct: 181 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 240
Query: 241 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 300
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
Sbjct: 241 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 300
Query: 301 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 360
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
Sbjct: 301 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 360
Query: 361 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 420
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
Sbjct: 361 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 420
Query: 421 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 480
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
Sbjct: 421 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 480
Query: 481 PPPYQEPRPRGNPPHSAPCVPNGSA----------------------------------- 505
PPPYQEPRPRGNPPHSAPCVPNGSA
Sbjct: 481 PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT 540
Query: 506 --YSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP 563
YSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP
Sbjct: 541 QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP 600
Query: 564 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 623
PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD
Sbjct: 601 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 660
Query: 624 ATKNA------RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLS 677
ATKNA RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLS
Sbjct: 661 ATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLS 720
Query: 678 AHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV 737
AHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV
Sbjct: 721 AHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV 780
Query: 738 GENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW 797
GENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW
Sbjct: 781 GENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW 840
Query: 798 EVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQ 857
EVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQ
Sbjct: 841 EVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQ 900
Query: 858 RPPFSQLHRFLAEDALNTV 876
RPPFSQLHRFLAEDALNTV
Sbjct: 901 RPPFSQLHRFLAEDALNTV 919
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 921 bits (2381), Expect = 0.0
Identities = 485/891 (54%), Positives = 599/891 (67%), Gaps = 67/891 (7%)
Query: 3 PEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHS 62
P L L LLL + S K +PA CRY LGM IPD DI+ASS WS+STAA++
Sbjct: 5 PRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYG 61
Query: 63 RLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR 121
RL+S +GDGAWCP V P + +E+LQ+DL LH + LVGTQGRHAGG G EF+ Y++
Sbjct: 62 RLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKIN 121
Query: 122 YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVE 181
YSRDG RW+ W++R G++V+ GN +P + LKDL PP+VAR VRF P D M+VC+RVE
Sbjct: 122 YSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVE 181
Query: 182 LYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLD 239
LYGC+W DGL+SY AP GQ L +YLNDS YDG VG GLGQL DGV GLD
Sbjct: 182 LYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLD 240
Query: 240 DFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPG 299
DF ++ E VWPGYDYVGW N S ++GY+E+ FEFDR+R F M+VHCNNM G ++
Sbjct: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300
Query: 300 GVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLF 359
V+C FR A WE + L + +P AR V+VPL R+A ++C++ FA W++F
Sbjct: 301 EVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMF 359
Query: 360 SEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI 418
SEI+F SD + N+S AL P +P + P P+ K + S T I
Sbjct: 360 SEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDSNTRI 400
Query: 419 LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNR--P 476
LIGCLVAII +LL II ++LWR W+++L KA RR+L++E+TV LS+P D+ + NN
Sbjct: 401 LIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSS 460
Query: 477 GPREP-------------PPYQEP-RPRGNPPHSAPCVPNGSAYSG--DYMEPEKPGAPL 520
P E P YQEP R P AP G SG ++P +P P
Sbjct: 461 SPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAP----GEEESGCSGVVKPVQPSGP- 515
Query: 521 LPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVD-FPRSRLRFKEKL 579
VPHYAEADIV LQGVTGGNTY+VPA+ + V+ FPR L FKEKL
Sbjct: 516 ------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKL 569
Query: 580 GEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIM 639
GEGQFGEVHLCEV+ + DF L+V P+LVAVK+LR DA KNARNDFLKE+KIM
Sbjct: 570 GEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIM 629
Query: 640 SRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGP 699
SRLKDPNII LL VC+ DDPLCMIT+YMENGDLNQFLS H+ P + ++
Sbjct: 630 SRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE---------PPNSSSSDVR 680
Query: 700 TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDY 759
T+SY L +A QIASGM+YL++LNFVHRDLATRNCLVG+N+TIKIADFGMSRNLY+GDY
Sbjct: 681 TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDY 740
Query: 760 YRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIEN 819
YR+QGRAVLPIRWM+WE IL+GKFTTASDVWAFGVTLWE C+ QP+ QL+DEQVIEN
Sbjct: 741 YRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 800
Query: 820 AGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE 870
GEFFRDQGRQ YL +P CP +Y+LML CW R+++ RP F ++H L +
Sbjct: 801 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQ 851
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 921 bits (2381), Expect = 0.0
Identities = 485/891 (54%), Positives = 599/891 (67%), Gaps = 67/891 (7%)
Query: 3 PEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHS 62
P L L LLL + S K +PA CRY LGM IPD DI+ASS WS+STAA++
Sbjct: 5 PRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYG 61
Query: 63 RLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR 121
RL+S +GDGAWCP V P + +E+LQ+DL LH + LVGTQGRHAGG G EF+ Y++
Sbjct: 62 RLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKIN 121
Query: 122 YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVE 181
YSRDG RW+ W++R G++V+ GN +P + LKDL PP+VAR VRF P D M+VC+RVE
Sbjct: 122 YSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVE 181
Query: 182 LYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLD 239
LYGC+W DGL+SY AP GQ L +YLNDS YDG VG GLGQL DGV GLD
Sbjct: 182 LYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLD 240
Query: 240 DFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPG 299
DF ++ E VWPGYDYVGW N S ++GY+E+ FEFDR+R F M+VHCNNM G ++
Sbjct: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300
Query: 300 GVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLF 359
V+C FR A WE + L + +P AR V+VPL R+A ++C++ FA W++F
Sbjct: 301 EVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMF 359
Query: 360 SEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI 418
SEI+F SD + N+S AL P +P + P P+ K + S T I
Sbjct: 360 SEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDSNTRI 400
Query: 419 LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNR--P 476
LIGCLVAII +LL II ++LWR W+++L KA RR+L++E+TV LS+P D+ + NN
Sbjct: 401 LIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSS 460
Query: 477 GPREP-------------PPYQEP-RPRGNPPHSAPCVPNGSAYSG--DYMEPEKPGAPL 520
P E P YQEP R P AP G SG ++P +P P
Sbjct: 461 SPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAP----GEEESGCSGVVKPVQPSGP- 515
Query: 521 LPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVD-FPRSRLRFKEKL 579
VPHYAEADIV LQGVTGGNTY+VPA+ + V+ FPR L FKEKL
Sbjct: 516 ------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKL 569
Query: 580 GEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIM 639
GEGQFGEVHLCEV+ + DF L+V P+LVAVK+LR DA KNARNDFLKE+KIM
Sbjct: 570 GEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIM 629
Query: 640 SRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGP 699
SRLKDPNII LL VC+ DDPLCMIT+YMENGDLNQFLS H+ P + ++
Sbjct: 630 SRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE---------PPNSSSSDVR 680
Query: 700 TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDY 759
T+SY L +A QIASGM+YL++LNFVHRDLATRNCLVG+N+TIKIADFGMSRNLY+GDY
Sbjct: 681 TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDY 740
Query: 760 YRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIEN 819
YR+QGRAVLPIRWM+WE IL+GKFTTASDVWAFGVTLWE C+ QP+ QL+DEQVIEN
Sbjct: 741 YRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 800
Query: 820 AGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE 870
GEFFRDQGRQ YL +P CP +Y+LML CW R+++ RP F ++H L +
Sbjct: 801 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQ 851
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 247 bits (631), Expect = 3e-65
Identities = 144/304 (47%), Positives = 189/304 (62%), Gaps = 36/304 (11%)
Query: 570 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
R + K +LGEG FG+V L E + QD + LVAVK L+ DA+
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 579
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA- 685
NAR DF +E ++++ L+ +I++ GVCV+ DPL M+ +YM++GDLN+FL AH +
Sbjct: 580 NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 639
Query: 686 AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 744
AEG P PT ++ +LH+A QIA+GM YLA+ +FVHRDLATRNCLVGEN +K
Sbjct: 640 AEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVK 691
Query: 745 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 804
I DFGMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+ GV LWE+ +
Sbjct: 692 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 751
Query: 805 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 864
QP+ QL++ +VIE QGR L RP CPQ +YELML CW RE R +
Sbjct: 752 -QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 803
Query: 865 HRFL 868
H L
Sbjct: 804 HTLL 807
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 247 bits (631), Expect = 3e-65
Identities = 144/304 (47%), Positives = 189/304 (62%), Gaps = 36/304 (11%)
Query: 570 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
R + K +LGEG FG+V L E + QD + LVAVK L+ DA+
Sbjct: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 595
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA- 685
NAR DF +E ++++ L+ +I++ GVCV+ DPL M+ +YM++GDLN+FL AH +
Sbjct: 596 NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 655
Query: 686 AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 744
AEG P PT ++ +LH+A QIA+GM YLA+ +FVHRDLATRNCLVGEN +K
Sbjct: 656 AEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVK 707
Query: 745 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 804
I DFGMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+ GV LWE+ +
Sbjct: 708 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 767
Query: 805 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 864
QP+ QL++ +VIE QGR L RP CPQ +YELML CW RE R +
Sbjct: 768 -QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 819
Query: 865 HRFL 868
H L
Sbjct: 820 HTLL 823
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 241 bits (614), Expect = 3e-63
Identities = 138/300 (46%), Positives = 188/300 (62%), Gaps = 25/300 (8%)
Query: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
R + K +LGEG FG+V L E + L+ K +LVAVK L+ D T AR
Sbjct: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALK-DPTLAAR 582
Query: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
DF +E ++++ L+ +I++ GVC DPL M+ +YM++GDLN+FL AH +
Sbjct: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV-- 640
Query: 690 PGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 748
DGQ Q + +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N +KI DF
Sbjct: 641 --DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDF 698
Query: 749 GMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 808
GMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+FGV LWE+ + QP+
Sbjct: 699 GMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPW 757
Query: 809 GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 868
QL++ +VIE QGR L RP CP+ +Y++ML CW RE +QR ++++ L
Sbjct: 758 FQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 810
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 501 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 548
Query: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 549 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 608
Query: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 609 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 664
Query: 750 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 665 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 723
Query: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 724 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 772
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 507 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 554
Query: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 555 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 614
Query: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 615 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 670
Query: 750 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 671 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 729
Query: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 730 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 778
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 471 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 518
Query: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 519 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 578
Query: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 579 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 634
Query: 750 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 635 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 693
Query: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 694 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 742
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 231 bits (589), Expect = 2e-60
Identities = 138/314 (43%), Positives = 188/314 (59%), Gaps = 39/314 (12%)
Query: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
R + K +LGEG FG+V L E + L+ K +LVAVK L+ D T AR
Sbjct: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALK-DPTLAAR 582
Query: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
DF +E ++++ L+ +I++ GVC DPL M+ +YM++GDLN+FL AH +
Sbjct: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV-- 640
Query: 690 PGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 748
DGQ Q + +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N +KI DF
Sbjct: 641 --DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDF 698
Query: 749 GMSRNLYAGDYYR--------------VQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 794
GMSR++Y+ DYYR V G +LPIRWM E I+ KFTT SDVW+FGV
Sbjct: 699 GMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGV 758
Query: 795 TLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 854
LWE+ + QP+ QL++ +VIE QGR L RP CP+ +Y++ML CW RE
Sbjct: 759 ILWEIFTYGK-QPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQRE 810
Query: 855 SEQRPPFSQLHRFL 868
+QR ++++ L
Sbjct: 811 PQQRLNIKEIYKIL 824
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 226 bits (575), Expect = 9e-59
Identities = 127/314 (40%), Positives = 178/314 (56%), Gaps = 36/314 (11%)
Query: 566 VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 625
+++PR+ + + +GEG FG V + +P L F + VAVK+L+ +A+
Sbjct: 568 LEYPRNNIEYVRDIGEGAFGRVF--QARAPGLLPYEPFTM---------VAVKMLKEEAS 616
Query: 626 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL--------- 676
+ + DF +E +M+ +PNI++LLGVC P+C++ +YM GDLN+FL
Sbjct: 617 ADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVC 676
Query: 677 --SAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRN 734
S L +A +PG P +S L +A Q+A+GM YL+ FVHRDLATRN
Sbjct: 677 SLSHSDLSMRAQVSSPGP------PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRN 730
Query: 735 CLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 794
CLVGEN +KIADFG+SRN+Y+ DYY+ +PIRWM E I ++TT SDVWA+GV
Sbjct: 731 CLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGV 790
Query: 795 TLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 854
LWE+ QP+ + E+VI + RD LS P CP LY LM CWS+
Sbjct: 791 VLWEIFSY-GLQPYYGMAHEEVI----YYVRDGN---ILSCPENCPVELYNLMRLCWSKL 842
Query: 855 SEQRPPFSQLHRFL 868
RP F+ +HR L
Sbjct: 843 PADRPSFTSIHRIL 856
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 208 bits (529), Expect = 2e-53
Identities = 113/299 (37%), Positives = 170/299 (56%), Gaps = 22/299 (7%)
Query: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
+ P S +RF E+LGE FG+++ + P +D H LVA+K L+
Sbjct: 467 ELPLSAVRFMEELGECAFGKIYKGHLYLP----GMD--------HAQLVAIKTLKDYNNP 514
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686
+F +E +M+ L PNI+ LLG Q+ P+CM+ +Y+ GDL++FL
Sbjct: 515 QQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVG 574
Query: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746
+ DG ++ + LH+A QIA+GM YL++ FVH+DLA RN L+GE +KI+
Sbjct: 575 CSSDEDGTVKS--SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKIS 632
Query: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 806
D G+SR +Y+ DYYRVQ +++LPIRWM E I+ GKF++ SD+W+FGV LWE+ Q
Sbjct: 633 DLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF-GLQ 691
Query: 807 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
P+ ++++VIE + RQ+ L CP +Y LM CW+ +RP F +H
Sbjct: 692 PYYGFSNQEVIEMV------RKRQL-LPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIH 743
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 199 bits (506), Expect = 9e-51
Identities = 114/309 (36%), Positives = 172/309 (55%), Gaps = 28/309 (9%)
Query: 563 PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP 622
P + R ++ +LG+G FG V+ + +D++ + V AVK +
Sbjct: 1001 PDEWEVSREKITLLRELGQGSFGMVY---EGNARDIIKGEAETRV--------AVKTVNE 1049
Query: 623 DATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 682
A+ R +FL E +M +++RLLGV + P ++ + M +GDL +L + + E
Sbjct: 1050 SASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE 1109
Query: 683 DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 742
AE PG P + ++ +AA+IA GM YL FVHRDLA RNC+V +FT
Sbjct: 1110 ---AENNPGR------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFT 1160
Query: 743 IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLML 802
+KI DFGM+R++Y DYYR G+ +LP+RWMA E + G FTT+SD+W+FGV LWE+ L
Sbjct: 1161 VKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSL 1220
Query: 803 CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFS 862
QP+ L++EQV+ +F D G YL +P CP+ + +LM CW + RP F
Sbjct: 1221 AE-QPYQGLSNEQVL----KFVMDGG---YLDQPDNCPERVTDLMRMCWQFNPKMRPTFL 1272
Query: 863 QLHRFLAED 871
++ L +D
Sbjct: 1273 EIVNLLKDD 1281
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 199 bits (506), Expect = 9e-51
Identities = 114/309 (36%), Positives = 172/309 (55%), Gaps = 28/309 (9%)
Query: 563 PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP 622
P + R ++ +LG+G FG V+ + +D++ + V AVK +
Sbjct: 1013 PDEWEVSREKITLLRELGQGSFGMVY---EGNARDIIKGEAETRV--------AVKTVNE 1061
Query: 623 DATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 682
A+ R +FL E +M +++RLLGV + P ++ + M +GDL +L + + E
Sbjct: 1062 SASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE 1121
Query: 683 DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 742
AE PG P + ++ +AA+IA GM YL FVHRDLA RNC+V +FT
Sbjct: 1122 ---AENNPGR------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFT 1172
Query: 743 IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLML 802
+KI DFGM+R++Y DYYR G+ +LP+RWMA E + G FTT+SD+W+FGV LWE+ L
Sbjct: 1173 VKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSL 1232
Query: 803 CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFS 862
QP+ L++EQV+ +F D G YL +P CP+ + +LM CW + RP F
Sbjct: 1233 AE-QPYQGLSNEQVL----KFVMDGG---YLDQPDNCPERVTDLMRMCWQFNPKMRPTFL 1284
Query: 863 QLHRFLAED 871
++ L +D
Sbjct: 1285 EIVNLLKDD 1293
>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
Length = 943
Score = 198 bits (503), Expect = 2e-50
Identities = 112/295 (37%), Positives = 166/295 (56%), Gaps = 22/295 (7%)
Query: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 630
S +RF E+LGE +FG+V+ + P VA+K L+ A R
Sbjct: 471 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQ-----------AVAIKTLKDKAEGPLRE 519
Query: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 690
+F E + +RL+ PN++ LLGV +D PL MI Y +GDL++FL G+
Sbjct: 520 EFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDV--GST 577
Query: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 750
D + + + P +H+ AQIA+GM YL++ + VH+DLATRN LV + +KI+D G+
Sbjct: 578 DDDRTVKS-ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 636
Query: 751 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ 810
R +YA DYY++ G ++LPIRWMA E I+ GKF+ SD+W++GV LWEV QP+
Sbjct: 637 FREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSY-GLQPYCG 695
Query: 811 LTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
+++ V+E + RQV L P CP +Y LM+ CW+ +RP F +H
Sbjct: 696 YSNQDVVEMI------RNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIH 743
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 197 bits (502), Expect = 3e-50
Identities = 121/341 (35%), Positives = 189/341 (55%), Gaps = 42/341 (12%)
Query: 534 EADIVTLQGVTGG-----NTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVH 588
+ ++ L+G+ G YA+ LP + P FPR +L + LG G FGEV+
Sbjct: 1903 DKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPA--FPREKLTLRLLLGSGAFGEVY 1960
Query: 589 LCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNII 648
+ ++D L V G + VAVK L+ +T + +FLKE +MS+ PNI+
Sbjct: 1961 --------EGTAVDI-LGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 2010
Query: 649 RLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLH 708
+ LGVC+ ++P +I + ME GDL +L ++ GP ++ L+
Sbjct: 2011 KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMA------------TFYGPLLTLVDLVD 2058
Query: 709 VAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFT----IKIADFGMSRNLYAGDYYRVQ 763
+ I+ G YL ++F+HRDLA RNCLV +++T +KI DFG++R++Y DYYR +
Sbjct: 2059 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 2118
Query: 764 GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEF 823
G +LP+RWMA E ++ G FTT SDVW+FG+ +WE+L L QP+ ++ V+ +
Sbjct: 2119 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH-QPYPAHSNLDVL----NY 2173
Query: 824 FRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 864
+ GR L P CP L+ LM +CW++E +QRP F ++
Sbjct: 2174 VQTGGR---LEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI 2211
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 194 bits (494), Expect = 2e-49
Identities = 120/310 (38%), Positives = 166/310 (53%), Gaps = 30/310 (9%)
Query: 563 PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLL-VAVKILR 621
P + PR ++ +LG+G FG V+ + G VA+K +
Sbjct: 969 PDEWEVPREQISIIRELGQGSFGMVYE------------GLARGLEAGEESTPVALKTVN 1016
Query: 622 PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL 681
A+ +FLKE +M K +++RLLGV Q P +I + M GDL L + +
Sbjct: 1017 ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP 1076
Query: 682 EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENF 741
E AE PG Q A G ++ +A +IA GM YLA FVHRDLA RNC+V ++F
Sbjct: 1077 E---AENNPGLPQPALGE------MIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDF 1127
Query: 742 TIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLM 801
T+KI DFGM+R++Y DYYR G+ +LP+RWMA E + G FTT SDVW+FGV LWE++
Sbjct: 1128 TVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVT 1187
Query: 802 LCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPF 861
L QP+ L++EQV+ +F D G L CP L ELM RCW RP F
Sbjct: 1188 LAE-QPYQGLSNEQVL----KFVMDGG---VLEELEGCPLQLQELMSRCWQPNPRLRPSF 1239
Query: 862 SQLHRFLAED 871
+ + + E+
Sbjct: 1240 THILDSIQEE 1249
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 193 bits (490), Expect = 7e-49
Identities = 112/300 (37%), Positives = 160/300 (53%), Gaps = 44/300 (14%)
Query: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
+ R+ + K KLG GQ+GEV+ V K + L VAVK L+ D +
Sbjct: 236 EMERTDITMKHKLGGGQYGEVYE----------------GVWKKYSLTVAVKTLKEDTME 279
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686
+FLKE +M +K PN+++LLGVC ++ P +IT++M G+L +L ++
Sbjct: 280 V--EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE--- 334
Query: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746
++ +LL++A QI+S M YL NF+HRDLA RNCLVGEN +K+A
Sbjct: 335 --------------VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA 380
Query: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 806
DFG+SR L GD Y A PI+W A E + KF+ SDVWAFGV LWE+
Sbjct: 381 DFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATY-GMS 438
Query: 807 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHR 866
P+ + QV E + +R + RP CP+ +YELM CW RP F+++H+
Sbjct: 439 PYPGIDLSQVYELLEKDYR-------MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 491
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 193 bits (490), Expect = 7e-49
Identities = 112/300 (37%), Positives = 160/300 (53%), Gaps = 44/300 (14%)
Query: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
+ R+ + K KLG GQ+GEV+ V K + L VAVK L+ D +
Sbjct: 255 EMERTDITMKHKLGGGQYGEVYE----------------GVWKKYSLTVAVKTLKEDTME 298
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686
+FLKE +M +K PN+++LLGVC ++ P +IT++M G+L +L ++
Sbjct: 299 V--EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE--- 353
Query: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746
++ +LL++A QI+S M YL NF+HRDLA RNCLVGEN +K+A
Sbjct: 354 --------------VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA 399
Query: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 806
DFG+SR L GD Y A PI+W A E + KF+ SDVWAFGV LWE+
Sbjct: 400 DFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATY-GMS 457
Query: 807 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHR 866
P+ + QV E + +R + RP CP+ +YELM CW RP F+++H+
Sbjct: 458 PYPGIDLSQVYELLEKDYR-------MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 510
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 192 bits (487), Expect = 1e-48
Identities = 114/312 (36%), Positives = 165/312 (52%), Gaps = 34/312 (10%)
Query: 563 PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP 622
P + R ++ +LG+G FG V+ + V D P VA+K +
Sbjct: 989 PDEWEVAREKITMSRELGQGSFGMVY----EGVAKGVVKDEP-------ETRVAIKTVNE 1037
Query: 623 DATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 682
A+ R +FL E +M +++RLLGV Q P +I + M GDL +L + + E
Sbjct: 1038 AASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE 1097
Query: 683 DKAAEGAPGDGQAAQGPTISYPML---LHVAAQIASGMRYLATLNFVHRDLATRNCLVGE 739
+ P ++ P L + +A +IA GM YL FVHRDLA RNC+V E
Sbjct: 1098 ME------------NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE 1145
Query: 740 NFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEV 799
+FT+KI DFGM+R++Y DYYR G+ +LP+RWM+ E + G FTT SDVW+FGV LWE+
Sbjct: 1146 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEI 1205
Query: 800 LMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRP 859
L QP+ L++EQV+ F + G L +P CP L+ELM CW + RP
Sbjct: 1206 ATLAE-QPYQGLSNEQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRP 1257
Query: 860 PFSQLHRFLAED 871
F ++ + E+
Sbjct: 1258 SFLEIISSIKEE 1269
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 189 bits (481), Expect = 7e-48
Identities = 110/313 (35%), Positives = 171/313 (54%), Gaps = 30/313 (9%)
Query: 564 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 623
P+ +FPR L + LGEG+FG+V + + F L R G+ VAVK+L+ +
Sbjct: 715 PKWEFPRKNLVLGKTLGEGEFGKV----------VKATAFHLKGRAGYTT-VAVKMLKEN 763
Query: 624 ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 683
A+ + D L E ++ ++ P++I+L G C QD PL +I +Y + G L FL +
Sbjct: 764 ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR--- 820
Query: 684 KAAEGAPGDGQAAQGPTISYPM--------LLHVAAQIASGMRYLATLNFVHRDLATRNC 735
K G G G + ++ +P L+ A QI+ GM+YLA + VHRDLA RN
Sbjct: 821 KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNI 880
Query: 736 LVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVT 795
LV E +KI+DFG+SR++Y D Y + + +P++WMA E + +TT SDVW+FGV
Sbjct: 881 LVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVL 940
Query: 796 LWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRES 855
LWE++ L P+ + E++ R + RP C + +Y LML+CW +E
Sbjct: 941 LWEIVTL-GGNPYPGIPPERLFNLLKTGHR-------MERPDNCSEEMYRLMLQCWKQEP 992
Query: 856 EQRPPFSQLHRFL 868
++RP F+ + + L
Sbjct: 993 DKRPVFADISKDL 1005
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 189 bits (481), Expect = 7e-48
Identities = 110/313 (35%), Positives = 171/313 (54%), Gaps = 30/313 (9%)
Query: 564 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 623
P+ +FPR L + LGEG+FG+V + + F L R G+ VAVK+L+ +
Sbjct: 715 PKWEFPRKNLVLGKTLGEGEFGKV----------VKATAFHLKGRAGYTT-VAVKMLKEN 763
Query: 624 ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 683
A+ + D L E ++ ++ P++I+L G C QD PL +I +Y + G L FL +
Sbjct: 764 ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR--- 820
Query: 684 KAAEGAPGDGQAAQGPTISYPM--------LLHVAAQIASGMRYLATLNFVHRDLATRNC 735
K G G G + ++ +P L+ A QI+ GM+YLA + VHRDLA RN
Sbjct: 821 KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNI 880
Query: 736 LVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVT 795
LV E +KI+DFG+SR++Y D Y + + +P++WMA E + +TT SDVW+FGV
Sbjct: 881 LVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVL 940
Query: 796 LWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRES 855
LWE++ L P+ + E++ R + RP C + +Y LML+CW +E
Sbjct: 941 LWEIVTL-GGNPYPGIPPERLFNLLKTGHR-------MERPDNCSEEMYRLMLQCWKQEP 992
Query: 856 EQRPPFSQLHRFL 868
++RP F+ + + L
Sbjct: 993 DKRPVFADISKDL 1005
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 189 bits (481), Expect = 7e-48
Identities = 119/317 (37%), Positives = 171/317 (53%), Gaps = 24/317 (7%)
Query: 552 PALPPGAVG-DGP--PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVR 608
PAL G V D P P +FPR RL + LGEG FG+V E R
Sbjct: 403 PALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDP---------AR 453
Query: 609 KGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCVQDDPLCMITDYM 667
VAVK+L+ +A+ D + E+++M + + NII LLGVC Q+ PL +I +
Sbjct: 454 PDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA 513
Query: 668 ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVH 727
G+L +FL A + + +P ++++GP +S+P+L+ A Q+A GM+YL + +H
Sbjct: 514 AKGNLREFLRARR--PPGPDLSPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESRKCIH 570
Query: 728 RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTAS 787
RDLA RN LV E+ +KIADFG++R ++ DYY+ LP++WMA E + +T S
Sbjct: 571 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 630
Query: 788 DVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELM 847
DVW+FG+ LWE+ L P+ + E++ E R + RPP CP LY LM
Sbjct: 631 DVWSFGILLWEIFTL-GGSPYPGIPVEELFSLLREGHR-------MDRPPHCPPELYGLM 682
Query: 848 LRCWSRESEQRPPFSQL 864
CW QRP F QL
Sbjct: 683 RECWHAAPSQRPTFKQL 699
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 189 bits (481), Expect = 7e-48
Identities = 119/317 (37%), Positives = 171/317 (53%), Gaps = 24/317 (7%)
Query: 552 PALPPGAVG-DGP--PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVR 608
PAL G V D P P +FPR RL + LGEG FG+V E R
Sbjct: 443 PALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDP---------AR 493
Query: 609 KGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCVQDDPLCMITDYM 667
VAVK+L+ +A+ D + E+++M + + NII LLGVC Q+ PL +I +
Sbjct: 494 PDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA 553
Query: 668 ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVH 727
G+L +FL A + + +P ++++GP +S+P+L+ A Q+A GM+YL + +H
Sbjct: 554 AKGNLREFLRARR--PPGPDLSPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESRKCIH 610
Query: 728 RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTAS 787
RDLA RN LV E+ +KIADFG++R ++ DYY+ LP++WMA E + +T S
Sbjct: 611 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 670
Query: 788 DVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELM 847
DVW+FG+ LWE+ L P+ + E++ E R + RPP CP LY LM
Sbjct: 671 DVWSFGILLWEIFTL-GGSPYPGIPVEELFSLLREGHR-------MDRPPHCPPELYGLM 722
Query: 848 LRCWSRESEQRPPFSQL 864
CW QRP F QL
Sbjct: 723 RECWHAAPSQRPTFKQL 739
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 189 bits (481), Expect = 7e-48
Identities = 119/317 (37%), Positives = 171/317 (53%), Gaps = 24/317 (7%)
Query: 552 PALPPGAVG-DGP--PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVR 608
PAL G V D P P +FPR RL + LGEG FG+V E R
Sbjct: 443 PALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDP---------AR 493
Query: 609 KGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCVQDDPLCMITDYM 667
VAVK+L+ +A+ D + E+++M + + NII LLGVC Q+ PL +I +
Sbjct: 494 PDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA 553
Query: 668 ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVH 727
G+L +FL A + + +P ++++GP +S+P+L+ A Q+A GM+YL + +H
Sbjct: 554 AKGNLREFLRARR--PPGPDLSPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESRKCIH 610
Query: 728 RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTAS 787
RDLA RN LV E+ +KIADFG++R ++ DYY+ LP++WMA E + +T S
Sbjct: 611 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 670
Query: 788 DVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELM 847
DVW+FG+ LWE+ L P+ + E++ E R + RPP CP LY LM
Sbjct: 671 DVWSFGILLWEIFTL-GGSPYPGIPVEELFSLLREGHR-------MDRPPHCPPELYGLM 722
Query: 848 LRCWSRESEQRPPFSQL 864
CW QRP F QL
Sbjct: 723 RECWHAAPSQRPTFKQL 739
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 188 bits (478), Expect = 2e-47
Identities = 111/300 (37%), Positives = 156/300 (52%), Gaps = 44/300 (14%)
Query: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
+ R+ + K KLG GQ+GEV++ V K + L VAVK L+ D +
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 310
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686
+FLKE +M +K PN+++LLGVC + P ++T+YM G+L +L E+ A
Sbjct: 311 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTA 368
Query: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746
+LL++A QI+S M YL NF+HRDLA RNCLVGEN +K+A
Sbjct: 369 V-----------------VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVA 411
Query: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 806
DFG+SR L GD Y A PI+W A E + F+ SDVWAFGV LWE+
Sbjct: 412 DFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMS 469
Query: 807 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHR 866
P+ + QV + + +R + +P CP +YELM CW RP F++ H+
Sbjct: 470 PYPGIDLSQVYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 522
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 188 bits (478), Expect = 2e-47
Identities = 111/300 (37%), Positives = 156/300 (52%), Gaps = 44/300 (14%)
Query: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
+ R+ + K KLG GQ+GEV++ V K + L VAVK L+ D +
Sbjct: 282 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 325
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686
+FLKE +M +K PN+++LLGVC + P ++T+YM G+L +L E+ A
Sbjct: 326 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTA 383
Query: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746
+LL++A QI+S M YL NF+HRDLA RNCLVGEN +K+A
Sbjct: 384 V-----------------VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVA 426
Query: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 806
DFG+SR L GD Y A PI+W A E + F+ SDVWAFGV LWE+
Sbjct: 427 DFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMS 484
Query: 807 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHR 866
P+ + QV + + +R + +P CP +YELM CW RP F++ H+
Sbjct: 485 PYPGIDLSQVYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 537
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 188 bits (478), Expect = 2e-47
Identities = 111/300 (37%), Positives = 156/300 (52%), Gaps = 44/300 (14%)
Query: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
+ R+ + K KLG GQ+GEV++ V K + L VAVK L+ D +
Sbjct: 261 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 304
Query: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686
+FLKE +M +K PN+++LLGVC + P ++T+YM G+L +L E+ A
Sbjct: 305 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTA 362
Query: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746
+LL++A QI+S M YL NF+HRDLA RNCLVGEN +K+A
Sbjct: 363 V-----------------VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVA 405
Query: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 806
DFG+SR L GD Y A PI+W A E + F+ SDVWAFGV LWE+
Sbjct: 406 DFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMS 463
Query: 807 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHR 866
P+ + QV + + +R + +P CP +YELM CW RP F++ H+
Sbjct: 464 PYPGIDLSQVYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 516
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,124,822
Number of Sequences: 37866
Number of extensions: 2336774
Number of successful extensions: 15045
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 619
Number of HSP's successfully gapped in prelim test: 506
Number of HSP's that attempted gapping in prelim test: 10358
Number of HSP's gapped (non-prelim): 3588
length of query: 876
length of database: 18,247,518
effective HSP length: 111
effective length of query: 765
effective length of database: 14,044,392
effective search space: 10743959880
effective search space used: 10743959880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.