Search of human proteins with 38016937

Search of human proteins with 38016937

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]
         (1503 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]                   3027   0.0  
gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]      447   e-125
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                   417   e-116
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   153   1e-36
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   152   2e-36
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   151   5e-36
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   151   5e-36
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   151   5e-36
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   148   4e-35
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   148   4e-35
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   143   1e-33
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...   142   3e-33
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [...   142   3e-33
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [...   142   3e-33
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...   142   3e-33
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   141   5e-33
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   141   5e-33
gi|62420886 discoidin domain receptor family, member 2 precursor...   139   2e-32
gi|62420884 discoidin domain receptor family, member 2 precursor...   139   2e-32
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    137   6e-32
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   137   8e-32
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso...   137   8e-32
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                137   8e-32
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            135   3e-31
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           135   3e-31
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   133   1e-30
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   133   1e-30
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   133   1e-30
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec...   132   2e-30
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               130   1e-29

>gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]
          Length = 1503

 Score = 3027 bits (7848), Expect = 0.0
 Identities = 1503/1503 (100%), Positives = 1503/1503 (100%)

Query: 1    MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIV 60
            MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIV
Sbjct: 1    MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIV 60

Query: 61   LIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQ 120
            LIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQ
Sbjct: 61   LIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQ 120

Query: 121  FQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD 180
            FQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
Sbjct: 121  FQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD 180

Query: 181  TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTM 240
            TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTM
Sbjct: 181  TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTM 240

Query: 241  LLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDD 300
            LLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDD
Sbjct: 241  LLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDD 300

Query: 301  KKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLN 360
            KKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLN
Sbjct: 301  KKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLN 360

Query: 361  QVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEV 420
            QVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEV
Sbjct: 361  QVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEV 420

Query: 421  DFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEA 480
            DFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEA
Sbjct: 421  DFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEA 480

Query: 481  AKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVF 540
            AKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVF
Sbjct: 481  AKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVF 540

Query: 541  DAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEES 600
            DAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEES
Sbjct: 541  DAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEES 600

Query: 601  STDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGV 660
            STDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGV
Sbjct: 601  STDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGV 660

Query: 661  QADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELS 720
            QADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELS
Sbjct: 661  QADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELS 720

Query: 721  ENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGL 780
            ENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGL
Sbjct: 721  ENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGL 780

Query: 781  SLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGET 840
            SLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGET
Sbjct: 781  SLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGET 840

Query: 841  QPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESD 900
            QPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESD
Sbjct: 841  QPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESD 900

Query: 901  SVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAK 960
            SVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAK
Sbjct: 901  SVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAK 960

Query: 961  EAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQK 1020
            EAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQK
Sbjct: 961  EAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQK 1020

Query: 1021 LVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGD 1080
            LVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGD
Sbjct: 1021 LVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGD 1080

Query: 1081 GHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPV 1140
            GHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPV
Sbjct: 1081 GHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPV 1140

Query: 1141 LPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASS 1200
            LPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASS
Sbjct: 1141 LPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASS 1200

Query: 1201 PWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPD 1260
            PWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPD
Sbjct: 1201 PWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPD 1260

Query: 1261 IEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPI 1320
            IEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPI
Sbjct: 1261 IEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPI 1320

Query: 1321 ILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCG 1380
            ILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCG
Sbjct: 1321 ILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCG 1380

Query: 1381 GEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSK 1440
            GEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSK
Sbjct: 1381 GEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSK 1440

Query: 1441 PSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG 1500
            PSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG
Sbjct: 1441 PSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG 1500

Query: 1501 EKD 1503
            EKD
Sbjct: 1501 EKD 1503


>gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]
          Length = 1374

 Score =  447 bits (1149), Expect = e-125
 Identities = 262/585 (44%), Positives = 349/585 (59%), Gaps = 63/585 (10%)

Query: 36  EAPPAAEVS--SSFVILCVC--SLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTP 91
           +  P +E+S  SS  ++ V    L  +IVL+  C+ CCK   I FKEFE+   DE     
Sbjct: 19  DGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACL-CCKKGGIGFKEFENAEGDEYA-AD 76

Query: 92  PAEDTPSV--QSPAEVFTLSVPNISLPAPSQFQPSVEGLKS-QVARHSLNYIQEIGNGWF 148
            A+ +P+   Q+  +V+ L +  +SLP   Q   SV+ LKS  V RHSL Y++EIG GWF
Sbjct: 77  LAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWF 136

Query: 149 GKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAI 208
           GKV LGE+ +G S A+V+VKEL+ASA+ +EQ  FL+  +PY  L+H N+LQC+ QC E  
Sbjct: 137 GKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVT 196

Query: 209 PYLLVFEFCDLGDLKAYLRSEQ--EHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDL 266
           PYLLV EFC LGDLK YLRS +  E M  D +T  LQRMACEVA G+  +H+ +F+HSDL
Sbjct: 197 PYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRT--LQRMACEVACGVLHLHRNNFVHSDL 254

Query: 267 ALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQ 326
           ALRNC LT+DL VK+GDYG+   +Y+EDY  T D+   PLRW APELV      LL  DQ
Sbjct: 255 ALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQ 314

Query: 327 TKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEV 386
           TK  N+WSLGVT+WELF+   QPY   S+  VL   +RE+  KLPKPQL+   SDRWYEV
Sbjct: 315 TKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEV 374

Query: 387 LQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAA--- 443
           +QFCWL PE+RP AE+VH LL+YL  +   ++E +FE++W +L+P          AA   
Sbjct: 375 MQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPM 434

Query: 444 ------------FPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSR 491
                       FP+L+ FA D    + ++VLTVTETS+GL+FEY WEA +         
Sbjct: 435 LGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRG-------- 486

Query: 492 GHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDD--SGQDVPLRVPGVVPVFDAHNLSVGS 549
                           E F ++LS     +  +  +    P   PGVVPV  AH+ S+GS
Sbjct: 487 ---------------AEAFPATLSPGRTARLQELCAPDGAP---PGVVPVLSAHSPSLGS 528

Query: 550 DYYIQLEE---KSGSNLE----LDYPPALLTTDMDNPERTGPELS 587
           +Y+I+LEE    +G + +       PPA    D D+   T   L+
Sbjct: 529 EYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLA 573



 Score =  200 bits (508), Expect = 1e-50
 Identities = 184/599 (30%), Positives = 261/599 (43%), Gaps = 109/599 (18%)

Query: 944  LEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLL-----EDSLSAPFPASEPSLE--- 995
            + A++  + LN   ++ E    S+   D+    S +      D L A  P   P+     
Sbjct: 835  VSAIKLASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQ 894

Query: 996  ----TPDSLESVDVHEALLDS-LGSHTPQKLVPPD---KPADSGYETENLESPEWTLHPA 1047
                TPDSL+S+D+  +  D      +P    P     +  DSGY+TEN ESPE+ L  A
Sbjct: 895  KQVGTPDSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEA 954

Query: 1048 PEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFS 1107
             EG    EP    +    G  P P   +S +  G               +  YRDSAYFS
Sbjct: 955  QEGC---EPQAFAELASEGEGPGPETRLSTSLSG------------LNEKNPYRDSAYFS 999

Query: 1108 DNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCL------EARKSQPD 1161
            D ++E E  S       P         P PE  LP     ++  CL      EA+ S P 
Sbjct: 1000 DLEAEAEATS------GPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPG 1053

Query: 1162 ESCLSALHNSSDLELRAT------PEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDF 1215
            E     L         +T      PEP +   P +V P    + S + +L          
Sbjct: 1054 EVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLT--------- 1104

Query: 1216 ETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGML 1275
                  P  L S G N++E           +      GP      +      +L + G+ 
Sbjct: 1105 ------PVPLRSEG-NSSEFQGPPGLLSGPAPQKRMGGPGTPRAPL------RLALPGLP 1151

Query: 1276 DLSEDGMDADEED-ENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLL 1334
               E   + +EED E+SD+SDE+LR +++   S +SE+E      ++  ++  R+LRSLL
Sbjct: 1152 AALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSARNLRSLL 1211

Query: 1335 KPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELG---PCGGEACGPDLSG- 1390
            K  +  + +   ED +++KKAV+FFDDVTVYLFDQE+PT+ELG   P   E+    L G 
Sbjct: 1212 KMPSLLS-ETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGS 1270

Query: 1391 ---------PAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKP 1441
                     P  A GSP          ST EEGGGF WDDDF   P M+   +  ++  P
Sbjct: 1271 PGSPSAPNRPQQADGSP--------NGSTAEEGGGFAWDDDF---PLMTAKAAFAMALDP 1319

Query: 1442 SLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG 1500
                    + P PA  T    P  AP+SRF++SPA  + FS+TH++DSD E     E G
Sbjct: 1320 --------AAPAPAAPT----PTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAG 1366



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 87/404 (21%), Positives = 138/404 (34%), Gaps = 64/404 (15%)

Query: 1027 PADSGYETENLESPEWTLHPAPEGTADSEP---ATTGDGGHSGLPPNPVIVISDAGDGHR 1083
            P  +G   E   SP+ T   +PE     EP            G  P    + S  G    
Sbjct: 698  PVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPA 757

Query: 1084 GTEVTPE-TFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLP 1142
               VTP  T TA S G         D+     K + E  GT+   L      PLP    P
Sbjct: 758  PCLVTPSWTETASSGG---------DHPQAEPKLATEAEGTTGPRL------PLPSVPSP 802

Query: 1143 EQS----PAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEA 1198
             Q     P+ + S  +A  + PD    +     S ++L +    + +    +   +EDE 
Sbjct: 803  SQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAPSSEDED 862

Query: 1199 SSPWSVLNAELSSGDDFETQDD-----RPCTLASTGTNTNEL-LAYTNSALDKSLSSHSE 1252
            +       AE +SG   +T  D     RP  + +  +   ++    +  +LD   S+   
Sbjct: 863  T-------AEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASDG 915

Query: 1253 GPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESED 1312
            G ++  P   G   G+      LD   D  + +  +    ++ E         L+SE E 
Sbjct: 916  GYEVFSPSATGPSGGQ---PRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEG 972

Query: 1313 ETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETP 1372
                          G   R     +  N  +P  +          +F D+         P
Sbjct: 973  -------------PGPETRLSTSLSGLNEKNPYRDS--------AYFSDLEAEAEATSGP 1011

Query: 1373 TKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGG 1416
             K+ G  G  A GP+L    P++G P    C+    S + +G G
Sbjct: 1012 EKKCG--GDRAPGPELG--LPSTGQPSEQVCLRPGVSGEAQGSG 1051


>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score =  417 bits (1073), Expect = e-116
 Identities = 251/610 (41%), Positives = 352/610 (57%), Gaps = 61/610 (10%)

Query: 1   MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTG--AGEAPPAAEVSSSFVILCVCS-LII 57
           MP P AL      +LL  + A    A+P    G   G AP A   +   V+L  CS L+ 
Sbjct: 30  MPAPGAL------ILLAAVSASGCLASPAHPDGFALGRAPLAPPYA---VVLISCSGLLA 80

Query: 58  LIVLIANCVSCCKDPEIDFKEFEDNFDDEI--DFTPPAEDTPSVQSPAEVFTLSVPNISL 115
            I L+  C+ CCK  ++ FKEFE+   ++   ++TPPAE+T S QS  +V+ L +  +SL
Sbjct: 81  FIFLLLTCL-CCKRGDVGFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSL 139

Query: 116 PAPSQFQPSVEGLKSQV--ARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKAS 173
           P P+  QPS   + + +  +R  L+Y+QEIG+GWFGKV+LGEI++  + A+V+VKEL+AS
Sbjct: 140 PMPAP-QPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRAS 198

Query: 174 ANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQ--- 230
           A P EQ  F+   +PY  LQHPN+LQC+G CVE +P+LL+ EFC LGDLK YLR+++   
Sbjct: 199 AGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPE 258

Query: 231 ----EHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGI 286
               E    D +T  LQRM  E+A GLA +H  +++HSDLALRNC LTSDL V++GDYG+
Sbjct: 259 GLSPELPPRDLRT--LQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGL 316

Query: 287 GFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNA 346
             S YKEDY  T ++   PLRW APEL+       +  DQ++ SNIWSLGVTLWELF+  
Sbjct: 317 AHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFG 376

Query: 347 AQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRL 406
           AQPY +LS+ +VL  V+R++  KL +P+L+ PY+D WY++LQ CW  P +RP+A D+   
Sbjct: 377 AQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQ 436

Query: 407 LTYL------RLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREME 460
           LTYL      R         D    W     ++  R  + ++ FP+LD F     G + +
Sbjct: 437 LTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFP----GADPD 492

Query: 461 EVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPG 520
           +VLTVTE+S+GL+ E +WE A+        RG                 ++ + + P P 
Sbjct: 493 DVLTVTESSRGLNLECLWEKARRG----AGRGG------------GAPAWQPASAPPAPH 536

Query: 521 KQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMD--N 578
               +     L  P V+PV  A + SV S+YYI+LEE          P  L   D D  +
Sbjct: 537 ANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSP------PEPLFPNDWDPLD 590

Query: 579 PERTGPELSQ 588
           P    P+  Q
Sbjct: 591 PGVPAPQAPQ 600



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 141/538 (26%), Positives = 190/538 (35%), Gaps = 70/538 (13%)

Query: 938  RRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETP 997
            RR EK LE  E  +    +      GL    S D  S++  L    +   P        P
Sbjct: 997  RREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAP 1056

Query: 998  DSLESVDVHEALLDSLGSHTPQ-KLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEP 1056
               E          ++G   P+  L     P+         E+    L PAP+     EP
Sbjct: 1057 GPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKN-GTLEP 1115

Query: 1057 ATTGDGGHSGLPPN-PVIVISDAGDGHRGTEVTPETFTAGSQGSYRDS-AYFSDND--SE 1112
             T      +G  P  P     D G G R   V   T   G  GS  D+ A + DN     
Sbjct: 1116 GTERRAPETGGAPRAPGAGRLDLGSGGRAP-VGTGTAPGGGPGSGVDAKAGWVDNTRPQP 1174

Query: 1113 PEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSS 1172
            P       P   P  L     +  PE V PE  P A DS                     
Sbjct: 1175 PPPPLPPPPEAQPRRLEPAPPRARPE-VAPEGEPGAPDS--------------------- 1212

Query: 1173 DLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNT 1232
                RA  + A +G      P       P   L+     G+  + +              
Sbjct: 1213 ----RAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIK-------------- 1254

Query: 1233 NELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLG-----VSGMLDLSEDGMDADEE 1287
               L+  + AL     +   GP  + P  EG   G  G             EDG D DE+
Sbjct: 1255 -ARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDED 1313

Query: 1288 DENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDG---RHLRSLLKPTAANAPDP 1344
            +E     DE+  A    +           PVP+++S+ D    R LR LLK +   A +P
Sbjct: 1314 EEE----DEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLK-SPRGADEP 1368

Query: 1345 LPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCI 1404
               + ++++K V+F  DVTVYLFDQETPT EL          D S P      P+ +   
Sbjct: 1369 EDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPG 1428

Query: 1405 NSESSTDEE-GGGFEWDDDFS--PDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTE 1459
            +   S D   GG FEW +DF   P P      S   S  P+L+T     P PPAR+ +
Sbjct: 1429 DGFPSNDSGFGGSFEWAEDFPLLPPPGPPLCFSR-FSVSPALET-----PGPPARAPD 1480



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 34/95 (35%), Positives = 36/95 (37%), Gaps = 15/95 (15%)

Query: 985  APFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTL 1044
            AP P   P     D   S D   A+  S GS       P  KP DSGYETE   SPE   
Sbjct: 781  APPPPPPPPRAPADPAASPDPPSAVA-SPGSGLSS---PGPKPGDSGYETETPFSPEGAF 836

Query: 1045 HPAPEGTADSE--------PATTGDGGHSGLPPNP 1071
               P G A  E        P    D G    PP+P
Sbjct: 837  ---PGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDP 868


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score =  153 bits (386), Expect = 1e-36
 Identities = 118/392 (30%), Positives = 180/392 (45%), Gaps = 37/392 (9%)

Query: 40  AAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSV 99
           A  V +S V  C+  ++ L+ L  +     K P       +D+    +       +TPS 
Sbjct: 435 AVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISN-DDDSASPLHHISNGSNTPSS 493

Query: 100 QSPAE----VFTLSVPNISLP-----APSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGK 150
                    +    +P I  P       SQ +P        + RH++   +E+G G FGK
Sbjct: 494 SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDT--FVQHIKRHNIVLKRELGEGAFGK 551

Query: 151 VLLGEIYT---GTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEA 207
           V L E Y          V VK LK +++   +D F +  E    LQH +I++  G CVE 
Sbjct: 552 VFLAECYNLCPEQDKILVAVKTLKDASDNARKD-FHREAELLTNLQHEHIVKFYGVCVEG 610

Query: 208 IPYLLVFEFCDLGDLKAYLRSEQEHM----RGDSQTMLLQ----RMACEVAAGLAAMHKL 259
            P ++VFE+   GDL  +LR+          G+  T L Q     +A ++AAG+  +   
Sbjct: 611 DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ 670

Query: 260 HFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQD 319
           HF+H DLA RNC +  +L VK+GD+G+    Y  DY       + P+RW  PE   S   
Sbjct: 671 HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE---SIMY 727

Query: 320 RLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPY 379
           R  T +    S++WSLGV LWE+F    QP+  LSN +V+  + + R  + P+   ++  
Sbjct: 728 RKFTTE----SDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEV- 782

Query: 380 SDRWYEVLQFCW-LSPEKRPAAEDVHRLLTYL 410
               YE++  CW   P  R   + +H LL  L
Sbjct: 783 ----YELMLGCWQREPHMRKNIKGIHTLLQNL 810


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score =  152 bits (384), Expect = 2e-36
 Identities = 102/304 (33%), Positives = 152/304 (50%), Gaps = 27/304 (8%)

Query: 119 SQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYT---GTSVARVIVKELKASAN 175
           SQ +P        + RH++   +E+G G FGKV L E Y          V VK LK +++
Sbjct: 538 SQLKPDT--FVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASD 595

Query: 176 PKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHM-- 233
              +D F +  E    LQH +I++  G CVE  P ++VFE+   GDL  +LR+       
Sbjct: 596 NARKD-FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVL 654

Query: 234 --RGDSQTMLLQ----RMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIG 287
              G+  T L Q     +A ++AAG+  +   HF+H DLA RNC +  +L VK+GD+G+ 
Sbjct: 655 MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMS 714

Query: 288 FSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAA 347
              Y  DY       + P+RW  PE   S   R  T +    S++WSLGV LWE+F    
Sbjct: 715 RDVYSTDYYRVGGHTMLPIRWMPPE---SIMYRKFTTE----SDVWSLGVVLWEIFTYGK 767

Query: 348 QPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAEDVHRL 406
           QP+  LSN +V+  + + R  + P+   ++      YE++  CW   P  R   + +H L
Sbjct: 768 QPWYQLSNNEVIECITQGRVLQRPRTCPQEV-----YELMLGCWQREPHMRKNIKGIHTL 822

Query: 407 LTYL 410
           L  L
Sbjct: 823 LQNL 826


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  151 bits (381), Expect = 5e-36
 Identities = 95/283 (33%), Positives = 143/283 (50%), Gaps = 27/283 (9%)

Query: 142 EIGNGWFGKVLLGEIYT---GTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNIL 198
           E+G G FGKV L E +          V VK LK ++    QD F +  E   +LQH +I+
Sbjct: 509 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD-FQREAELLTMLQHQHIV 567

Query: 199 QCVGQCVEAIPYLLVFEFCDLGDLKAYLRSE----------QEHMRGDSQTMLLQRMACE 248
           +  G C E  P L+VFE+   GDL  +LRS           ++   G      L  +A +
Sbjct: 568 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 627

Query: 249 VAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRW 308
           VAAG+  +  LHF+H DLA RNC +   L VK+GD+G+    Y  DY     + + P+RW
Sbjct: 628 VAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW 687

Query: 309 TAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDT 368
             PE        +L    T  S++WS GV LWE+F    QP+  LSN + ++ + + R+ 
Sbjct: 688 MPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL 740

Query: 369 KLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAEDVHRLLTYL 410
           + P+    + Y+     +++ CW   P++R + +DVH  L  L
Sbjct: 741 ERPRACPPEVYA-----IMRGCWQREPQQRHSIKDVHARLQAL 778


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  151 bits (381), Expect = 5e-36
 Identities = 95/283 (33%), Positives = 143/283 (50%), Gaps = 27/283 (9%)

Query: 142 EIGNGWFGKVLLGEIYT---GTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNIL 198
           E+G G FGKV L E +          V VK LK ++    QD F +  E   +LQH +I+
Sbjct: 515 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD-FQREAELLTMLQHQHIV 573

Query: 199 QCVGQCVEAIPYLLVFEFCDLGDLKAYLRSE----------QEHMRGDSQTMLLQRMACE 248
           +  G C E  P L+VFE+   GDL  +LRS           ++   G      L  +A +
Sbjct: 574 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 633

Query: 249 VAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRW 308
           VAAG+  +  LHF+H DLA RNC +   L VK+GD+G+    Y  DY     + + P+RW
Sbjct: 634 VAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW 693

Query: 309 TAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDT 368
             PE        +L    T  S++WS GV LWE+F    QP+  LSN + ++ + + R+ 
Sbjct: 694 MPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL 746

Query: 369 KLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAEDVHRLLTYL 410
           + P+    + Y+     +++ CW   P++R + +DVH  L  L
Sbjct: 747 ERPRACPPEVYA-----IMRGCWQREPQQRHSIKDVHARLQAL 784


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  151 bits (381), Expect = 5e-36
 Identities = 95/283 (33%), Positives = 143/283 (50%), Gaps = 27/283 (9%)

Query: 142 EIGNGWFGKVLLGEIYT---GTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNIL 198
           E+G G FGKV L E +          V VK LK ++    QD F +  E   +LQH +I+
Sbjct: 479 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD-FQREAELLTMLQHQHIV 537

Query: 199 QCVGQCVEAIPYLLVFEFCDLGDLKAYLRSE----------QEHMRGDSQTMLLQRMACE 248
           +  G C E  P L+VFE+   GDL  +LRS           ++   G      L  +A +
Sbjct: 538 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 597

Query: 249 VAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRW 308
           VAAG+  +  LHF+H DLA RNC +   L VK+GD+G+    Y  DY     + + P+RW
Sbjct: 598 VAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW 657

Query: 309 TAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDT 368
             PE        +L    T  S++WS GV LWE+F    QP+  LSN + ++ + + R+ 
Sbjct: 658 MPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL 710

Query: 369 KLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAEDVHRLLTYL 410
           + P+    + Y+     +++ CW   P++R + +DVH  L  L
Sbjct: 711 ERPRACPPEVYA-----IMRGCWQREPQQRHSIKDVHARLQAL 748


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  148 bits (373), Expect = 4e-35
 Identities = 107/326 (32%), Positives = 163/326 (50%), Gaps = 39/326 (11%)

Query: 93   AEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVL 152
            A   P   S ++VF  SV       P +++         V+R  +  ++E+G G FG V 
Sbjct: 981  ASSNPEYLSASDVFPCSVY-----VPDEWE---------VSREKITLLRELGQGSFGMVY 1026

Query: 153  LG---EIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIP 209
             G   +I  G +  RV VK +  SA+ +E+  FL            ++++ +G   +  P
Sbjct: 1027 EGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP 1086

Query: 210  YLLVFEFCDLGDLKAYLRS---EQEHMRGDSQTMLLQ--RMACEVAAGLAAMHKLHFLHS 264
             L+V E    GDLK+YLRS   E E+  G     L +  +MA E+A G+A ++   F+H 
Sbjct: 1087 TLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHR 1146

Query: 265  DLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTA 324
            DLA RNC +  D  VK+GD+G+    Y+ DY     K + P+RW APE   S +D + T 
Sbjct: 1147 DLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE---SLKDGVFTT 1203

Query: 325  DQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYS--DR 382
                 S++WS GV LWE+   A QPY  LSN  VL  V       +    L+QP +  +R
Sbjct: 1204 S----SDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-------MDGGYLDQPDNCPER 1252

Query: 383  WYEVLQFCW-LSPEKRPAAEDVHRLL 407
              ++++ CW  +P+ RP   ++  LL
Sbjct: 1253 VTDLMRMCWQFNPKMRPTFLEIVNLL 1278


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  148 bits (373), Expect = 4e-35
 Identities = 107/326 (32%), Positives = 163/326 (50%), Gaps = 39/326 (11%)

Query: 93   AEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVL 152
            A   P   S ++VF  SV       P +++         V+R  +  ++E+G G FG V 
Sbjct: 993  ASSNPEYLSASDVFPCSVY-----VPDEWE---------VSREKITLLRELGQGSFGMVY 1038

Query: 153  LG---EIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIP 209
             G   +I  G +  RV VK +  SA+ +E+  FL            ++++ +G   +  P
Sbjct: 1039 EGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP 1098

Query: 210  YLLVFEFCDLGDLKAYLRS---EQEHMRGDSQTMLLQ--RMACEVAAGLAAMHKLHFLHS 264
             L+V E    GDLK+YLRS   E E+  G     L +  +MA E+A G+A ++   F+H 
Sbjct: 1099 TLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHR 1158

Query: 265  DLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTA 324
            DLA RNC +  D  VK+GD+G+    Y+ DY     K + P+RW APE   S +D + T 
Sbjct: 1159 DLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE---SLKDGVFTT 1215

Query: 325  DQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYS--DR 382
                 S++WS GV LWE+   A QPY  LSN  VL  V       +    L+QP +  +R
Sbjct: 1216 S----SDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-------MDGGYLDQPDNCPER 1264

Query: 383  WYEVLQFCW-LSPEKRPAAEDVHRLL 407
              ++++ CW  +P+ RP   ++  LL
Sbjct: 1265 VTDLMRMCWQFNPKMRPTFLEIVNLL 1290


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  143 bits (361), Expect = 1e-33
 Identities = 93/279 (33%), Positives = 144/279 (51%), Gaps = 23/279 (8%)

Query: 131  QVARHSLNYIQEIGNGWFGKVLLGE---IYTGTSVARVIVKELKASANPKEQDTFLKNGE 187
            +VAR  +   +E+G G FG V  G    +       RV +K +  +A+ +E+  FL    
Sbjct: 993  EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1052

Query: 188  PYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGD------SQTML 241
                    ++++ +G   +  P L++ E    GDLK+YLRS +  M  +      S + +
Sbjct: 1053 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 1112

Query: 242  LQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDK 301
            +Q MA E+A G+A ++   F+H DLA RNC +  D  VK+GD+G+    Y+ DY     K
Sbjct: 1113 IQ-MAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGK 1171

Query: 302  KVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQ 361
             + P+RW +PE   S +D + T     YS++WS GV LWE+   A QPY  LSN  VL  
Sbjct: 1172 GLLPVRWMSPE---SLKDGVFTT----YSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRF 1224

Query: 362  VIRERDTKLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPA 399
            V+      L KP       D  +E+++ CW  +P+ RP+
Sbjct: 1225 VM--EGGLLDKP---DNCPDMLFELMRMCWQYNPKMRPS 1258


>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
            sapiens]
          Length = 1070

 Score =  142 bits (357), Expect = 3e-33
 Identities = 114/391 (29%), Positives = 190/391 (48%), Gaps = 33/391 (8%)

Query: 28   PLPQT--GAGEAPPAAEVSSSFVIL--CVCSLIILIVLIANCVSCCKDPEIDFK-EFEDN 82
            P+P+   G G  PP   + +  + +   V  +I ++ L+  C   CK   +  + E E+ 
Sbjct: 685  PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 744

Query: 83   FDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQE 142
              + ++  P     PS +   EV   S+   S PA +  + S    K    R SL  I  
Sbjct: 745  EMECLNGGPLQNGQPSAEIQEEVALTSLG--SGPAATNKRHSTSD-KMHFPRSSLQPITT 801

Query: 143  IGNGWFGKVLLGE---IYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQ 199
            +G   FG+V L +   +  G +   V+VK L+ S + ++Q  F +  E +  L H N+++
Sbjct: 802  LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVR 860

Query: 200  CVGQCVEAIPYLLVFEFCDLGDLKAYLR---SEQEHMRGDSQTMLLQRMAC-EVAAGLAA 255
             +G C EA P+ +V E+ DLGDLK +LR   S+ E ++    +   +   C +VA G+  
Sbjct: 861  LLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 920

Query: 256  MHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVT 315
            +    F+H DLA RNC +++   VKV   G+    Y  +Y       V PLRW +PE + 
Sbjct: 921  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWV-PLRWMSPEAI- 978

Query: 316  SFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQL 375
                  L  D +  S++W+ GV +WE+F +   P+   ++ +VL       D +  K +L
Sbjct: 979  ------LEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL------ADLQAGKARL 1026

Query: 376  EQPYS--DRWYEVLQFCW-LSPEKRPAAEDV 403
             QP     + Y ++Q CW LSP+ RP+  ++
Sbjct: 1027 PQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1057


>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
            sapiens]
          Length = 1014

 Score =  142 bits (357), Expect = 3e-33
 Identities = 114/391 (29%), Positives = 190/391 (48%), Gaps = 33/391 (8%)

Query: 28   PLPQT--GAGEAPPAAEVSSSFVIL--CVCSLIILIVLIANCVSCCKDPEIDFK-EFEDN 82
            P+P+   G G  PP   + +  + +   V  +I ++ L+  C   CK   +  + E E+ 
Sbjct: 629  PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 688

Query: 83   FDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQE 142
              + ++  P     PS +   EV   S+   S PA +  + S    K    R SL  I  
Sbjct: 689  EMECLNGGPLQNGQPSAEIQEEVALTSLG--SGPAATNKRHSTSD-KMHFPRSSLQPITT 745

Query: 143  IGNGWFGKVLLGE---IYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQ 199
            +G   FG+V L +   +  G +   V+VK L+ S + ++Q  F +  E +  L H N+++
Sbjct: 746  LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVR 804

Query: 200  CVGQCVEAIPYLLVFEFCDLGDLKAYLR---SEQEHMRGDSQTMLLQRMAC-EVAAGLAA 255
             +G C EA P+ +V E+ DLGDLK +LR   S+ E ++    +   +   C +VA G+  
Sbjct: 805  LLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 864

Query: 256  MHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVT 315
            +    F+H DLA RNC +++   VKV   G+    Y  +Y       V PLRW +PE + 
Sbjct: 865  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWV-PLRWMSPEAI- 922

Query: 316  SFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQL 375
                  L  D +  S++W+ GV +WE+F +   P+   ++ +VL       D +  K +L
Sbjct: 923  ------LEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL------ADLQAGKARL 970

Query: 376  EQPYS--DRWYEVLQFCW-LSPEKRPAAEDV 403
             QP     + Y ++Q CW LSP+ RP+  ++
Sbjct: 971  PQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1001


>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
           [Homo sapiens]
          Length = 940

 Score =  142 bits (357), Expect = 3e-33
 Identities = 114/391 (29%), Positives = 190/391 (48%), Gaps = 33/391 (8%)

Query: 28  PLPQT--GAGEAPPAAEVSSSFVIL--CVCSLIILIVLIANCVSCCKDPEIDFK-EFEDN 82
           P+P+   G G  PP   + +  + +   V  +I ++ L+  C   CK   +  + E E+ 
Sbjct: 555 PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 614

Query: 83  FDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQE 142
             + ++  P     PS +   EV   S+   S PA +  + S    K    R SL  I  
Sbjct: 615 EMECLNGGPLQNGQPSAEIQEEVALTSLG--SGPAATNKRHSTSD-KMHFPRSSLQPITT 671

Query: 143 IGNGWFGKVLLGE---IYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQ 199
           +G   FG+V L +   +  G +   V+VK L+ S + ++Q  F +  E +  L H N+++
Sbjct: 672 LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVR 730

Query: 200 CVGQCVEAIPYLLVFEFCDLGDLKAYLR---SEQEHMRGDSQTMLLQRMAC-EVAAGLAA 255
            +G C EA P+ +V E+ DLGDLK +LR   S+ E ++    +   +   C +VA G+  
Sbjct: 731 LLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 790

Query: 256 MHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVT 315
           +    F+H DLA RNC +++   VKV   G+    Y  +Y       V PLRW +PE + 
Sbjct: 791 LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWV-PLRWMSPEAI- 848

Query: 316 SFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQL 375
                 L  D +  S++W+ GV +WE+F +   P+   ++ +VL       D +  K +L
Sbjct: 849 ------LEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL------ADLQAGKARL 896

Query: 376 EQPYS--DRWYEVLQFCW-LSPEKRPAAEDV 403
            QP     + Y ++Q CW LSP+ RP+  ++
Sbjct: 897 PQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 927


>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
            sapiens]
          Length = 1030

 Score =  142 bits (357), Expect = 3e-33
 Identities = 114/391 (29%), Positives = 190/391 (48%), Gaps = 33/391 (8%)

Query: 28   PLPQT--GAGEAPPAAEVSSSFVIL--CVCSLIILIVLIANCVSCCKDPEIDFK-EFEDN 82
            P+P+   G G  PP   + +  + +   V  +I ++ L+  C   CK   +  + E E+ 
Sbjct: 645  PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 704

Query: 83   FDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQE 142
              + ++  P     PS +   EV   S+   S PA +  + S    K    R SL  I  
Sbjct: 705  EMECLNGGPLQNGQPSAEIQEEVALTSLG--SGPAATNKRHSTSD-KMHFPRSSLQPITT 761

Query: 143  IGNGWFGKVLLGE---IYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQ 199
            +G   FG+V L +   +  G +   V+VK L+ S + ++Q  F +  E +  L H N+++
Sbjct: 762  LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVR 820

Query: 200  CVGQCVEAIPYLLVFEFCDLGDLKAYLR---SEQEHMRGDSQTMLLQRMAC-EVAAGLAA 255
             +G C EA P+ +V E+ DLGDLK +LR   S+ E ++    +   +   C +VA G+  
Sbjct: 821  LLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 880

Query: 256  MHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVT 315
            +    F+H DLA RNC +++   VKV   G+    Y  +Y       V PLRW +PE + 
Sbjct: 881  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWV-PLRWMSPEAI- 938

Query: 316  SFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQL 375
                  L  D +  S++W+ GV +WE+F +   P+   ++ +VL       D +  K +L
Sbjct: 939  ------LEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL------ADLQAGKARL 986

Query: 376  EQPYS--DRWYEVLQFCW-LSPEKRPAAEDV 403
             QP     + Y ++Q CW LSP+ RP+  ++
Sbjct: 987  PQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1017


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score =  141 bits (355), Expect = 5e-33
 Identities = 85/290 (29%), Positives = 147/290 (50%), Gaps = 26/290 (8%)

Query: 132 VARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPK--EQDTFLKNGEPY 189
           + R  +   +E+G G FGKV L E Y  +     ++  +KA  +P    +  F +  E  
Sbjct: 533 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL 592

Query: 190 YILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRS-----------EQEHMRGDSQ 238
             LQH +I++  G C +  P ++VFE+   GDL  +LR+           +    +G+  
Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELG 652

Query: 239 TMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIET 298
              +  +A ++A+G+  +   HF+H DLA RNC + ++L VK+GD+G+    Y  DY   
Sbjct: 653 LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRV 712

Query: 299 DDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDV 358
               + P+RW  PE   S   R  T +    S++WS GV LWE+F    QP+  LSN +V
Sbjct: 713 GGHTMLPIRWMPPE---SIMYRKFTTE----SDVWSFGVILWEIFTYGKQPWFQLSNTEV 765

Query: 359 LNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAEDVHRLL 407
           +  + + R  + P+   ++      Y+V+  CW   P++R   ++++++L
Sbjct: 766 IECITQGRVLERPRVCPKEV-----YDVMLGCWQREPQQRLNIKEIYKIL 810


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  141 bits (355), Expect = 5e-33
 Identities = 117/390 (30%), Positives = 181/390 (46%), Gaps = 45/390 (11%)

Query: 122  QPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGE----IYTGTSVARVIVKELKASANPK 177
            Q  +E L +   R  L     +G+G FG+V  G     +  G+   +V VK LK  +  +
Sbjct: 1931 QEEIENLPA-FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQ 1989

Query: 178  EQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLR-SEQEHMRGD 236
            E+  FLK         HPNIL+ +G C+   P  ++ E  + GDL  YLR +      G 
Sbjct: 1990 EKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP 2049

Query: 237  SQTML-LQRMACEVAAGLAAMHKLHFLHSDLALRNCFL-----TSDLNVKVGDYGIGFSR 290
              T++ L  +  +++ G   + ++HF+H DLA RNC +     TS   VK+GD+G+    
Sbjct: 2050 LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI 2109

Query: 291  YKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPY 350
            YK DY     + + P+RW APE   S  D + T      S++WS G+ +WE+     QPY
Sbjct: 2110 YKNDYYRKRGEGLLPVRWMAPE---SLMDGIFTTQ----SDVWSFGILIWEILTLGHQPY 2162

Query: 351  SNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWL-SPEKRPAAEDVHRLLTY 409
               SNLDVLN V  +   +L  P   +   D  + ++  CW   P++RP         T+
Sbjct: 2163 PAHSNLDVLNYV--QTGGRLEPP---RNCPDDLWNLMTQCWAQEPDQRP---------TF 2208

Query: 410  LRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFA---RDRLGREMEEVLTVT 466
             R+Q Q     +F      L     SRD +NN+   I + F     D +    ++++ V 
Sbjct: 2209 HRIQDQLQLFRNF-----FLNSIYKSRDEANNSGV-INESFEGEDGDVICLNSDDIMPVA 2262

Query: 467  --ETSQGLSFEYVWEAAKHDHFDERSRGHL 494
              ET       Y+  A +    +E+S G L
Sbjct: 2263 LMETKNREGLNYMVLATECGQGEEKSEGPL 2292


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  139 bits (350), Expect = 2e-32
 Identities = 100/328 (30%), Positives = 161/328 (49%), Gaps = 42/328 (12%)

Query: 107 TLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEI---------- 156
           T SVP +++   S    +VE    +  R  L + +++G G FG+V L E+          
Sbjct: 537 TYSVPAVTMDLLSGKDVAVE----EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKD 592

Query: 157 ----YTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLL 212
                +      V VK L+A AN   ++ FLK  +    L+ PNI+  +  C+   P  +
Sbjct: 593 FALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCM 652

Query: 213 VFEFCDLGDLKAYL------RSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDL 266
           + E+ + GDL  +L       S    +R  S T L + MA ++A+G+  +  L+F+H DL
Sbjct: 653 ITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNL-KFMATQIASGMKYLSSLNFVHRDL 711

Query: 267 ALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQ 326
           A RNC +  +  +K+ D+G+  + Y  DY     + V P+RW + E        +L    
Sbjct: 712 ATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE-------SILLGKF 764

Query: 327 TKYSNIWSLGVTLWELFDNA-AQPYSNLSNLDVL---NQVIRE--RDTKLPKPQLEQPYS 380
           T  S++W+ GVTLWE F     QPYS LS+  V+    +  R+  R T LP+P +     
Sbjct: 765 TTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAI---CP 821

Query: 381 DRWYEVLQFCWLSPEK-RPAAEDVHRLL 407
           D  Y+++  CW    K RP+ +++H LL
Sbjct: 822 DSVYKLMLSCWRRDTKNRPSFQEIHLLL 849


>gi|62420884 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  139 bits (350), Expect = 2e-32
 Identities = 100/328 (30%), Positives = 161/328 (49%), Gaps = 42/328 (12%)

Query: 107 TLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEI---------- 156
           T SVP +++   S    +VE    +  R  L + +++G G FG+V L E+          
Sbjct: 537 TYSVPAVTMDLLSGKDVAVE----EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKD 592

Query: 157 ----YTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLL 212
                +      V VK L+A AN   ++ FLK  +    L+ PNI+  +  C+   P  +
Sbjct: 593 FALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCM 652

Query: 213 VFEFCDLGDLKAYL------RSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDL 266
           + E+ + GDL  +L       S    +R  S T L + MA ++A+G+  +  L+F+H DL
Sbjct: 653 ITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNL-KFMATQIASGMKYLSSLNFVHRDL 711

Query: 267 ALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQ 326
           A RNC +  +  +K+ D+G+  + Y  DY     + V P+RW + E        +L    
Sbjct: 712 ATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE-------SILLGKF 764

Query: 327 TKYSNIWSLGVTLWELFDNA-AQPYSNLSNLDVL---NQVIRE--RDTKLPKPQLEQPYS 380
           T  S++W+ GVTLWE F     QPYS LS+  V+    +  R+  R T LP+P +     
Sbjct: 765 TTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAI---CP 821

Query: 381 DRWYEVLQFCWLSPEK-RPAAEDVHRLL 407
           D  Y+++  CW    K RP+ +++H LL
Sbjct: 822 DSVYKLMLSCWRRDTKNRPSFQEIHLLL 849


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  137 bits (346), Expect = 6e-32
 Identities = 104/402 (25%), Positives = 179/402 (44%), Gaps = 46/402 (11%)

Query: 29  LPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEID 88
           LP + +     +   S + +I  + S  I ++L    + CC+      K++++   +   
Sbjct: 478 LPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRR----KQWKNKKRESAA 533

Query: 89  FTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWF 148
            T       ++ S   +  L    +    P    P +  L  +  R+++ Y+++IG G F
Sbjct: 534 VT-----LTTLPSELLLDRLHPNPMYQRMPLLLNPKL--LSLEYPRNNIEYVRDIGEGAF 586

Query: 149 GKVLLGE---IYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCV 205
           G+V       +        V VK LK  A+   Q  F +         +PNI++ +G C 
Sbjct: 587 GRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCA 646

Query: 206 EAIPYLLVFEFCDLGDLKAYLRSEQEH-----------MRGDSQTMLLQRMAC------- 247
              P  L+FE+   GDL  +LRS   H           MR    +     ++C       
Sbjct: 647 VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIA 706

Query: 248 -EVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPL 306
            +VAAG+A + +  F+H DLA RNC +  ++ VK+ D+G+  + Y  DY + ++    P+
Sbjct: 707 RQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPI 766

Query: 307 RWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRER 366
           RW  PE +  F +R  T      S++W+ GV LWE+F    QPY  +++ +V+  V   R
Sbjct: 767 RWMPPESI--FYNRYTTE-----SDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV---R 816

Query: 367 DTKLPKPQLEQPYSDRWYEVLQFCWLS-PEKRPAAEDVHRLL 407
           D  +       P     Y +++ CW   P  RP+   +HR+L
Sbjct: 817 DGNILSCPENCPV--ELYNLMRLCWSKLPADRPSFTSIHRIL 856


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  137 bits (345), Expect = 8e-32
 Identities = 86/241 (35%), Positives = 129/241 (53%), Gaps = 15/241 (6%)

Query: 131  QVARHSLNYIQEIGNGWFGKVLLG---EIYTGTSVARVIVKELKASANPKEQDTFLKNGE 187
            +V R  ++ I+E+G G FG V  G    +  G     V +K +   A+P+E   FLK   
Sbjct: 973  EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEAS 1032

Query: 188  PYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRS---EQEHMRGDSQTML--L 242
                 +  ++++ +G   +  P L++ E    GDLK++LRS   E E+  G  Q  L  +
Sbjct: 1033 VMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEM 1092

Query: 243  QRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKK 302
             +MA E+A G+A +    F+H DLA RNC ++ D  VK+GD+G+    Y+ DY     K 
Sbjct: 1093 IQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKG 1152

Query: 303  VFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQV 362
            + P+RW APE   S +D + T     +S++WS GV LWE+   A QPY  LSN  VL  V
Sbjct: 1153 LLPVRWMAPE---SLKDGIFTT----HSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV 1205

Query: 363  I 363
            +
Sbjct: 1206 M 1206


>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
           isoform 1 [Homo sapiens]
          Length = 937

 Score =  137 bits (345), Expect = 8e-32
 Identities = 96/347 (27%), Positives = 162/347 (46%), Gaps = 45/347 (12%)

Query: 112 NISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYT-GTSVARVI-VKE 169
           N+ +   + ++P  +    ++   ++ +++E+G   FGK+  G +Y  G   A+++ +K 
Sbjct: 450 NVEMSMLNAYKPKSKA--KELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKT 507

Query: 170 LKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSE 229
           LK   NP++   F +       L HPNI+  +G   +  P  ++FE+ + GDL  +L   
Sbjct: 508 LKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMR 567

Query: 230 QEHMR--------GDSQTML----LQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDL 277
             H          G  ++ L       +A ++AAG+  +    F+H DLA RN  +   L
Sbjct: 568 SPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQL 627

Query: 278 NVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGV 337
           +VK+ D G+    Y  DY     K + P+RW  PE +       +    +  S+IWS GV
Sbjct: 628 HVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAI-------MYGKFSSDSDIWSFGV 680

Query: 338 TLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLS-PEK 396
            LWE+F    QPY   SN +V+ +++R+R   LP     +    R Y ++  CW   P +
Sbjct: 681 VLWEIFSFGLQPYYGFSNQEVI-EMVRKRQL-LP---CSEDCPPRMYSLMTECWNEIPSR 735

Query: 397 RPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAA 443
           RP  +D+H     +RL+S           W  L  +T+S   S   A
Sbjct: 736 RPRFKDIH-----VRLRS-----------WEGLSSHTSSTTPSGGNA 766


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  137 bits (345), Expect = 8e-32
 Identities = 93/272 (34%), Positives = 138/272 (50%), Gaps = 23/272 (8%)

Query: 137 LNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPN 196
           L ++QEIG+G FG V LG       VA   +K ++  A  +E   F++  E    L HP 
Sbjct: 363 LTFVQEIGSGQFGLVHLGYWLNKDKVA---IKTIREGAMSEED--FIEEAEVMMKLSHPK 417

Query: 197 ILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAM 256
           ++Q  G C+E  P  LVFEF + G L  YLR++    RG      L  M  +V  G+A +
Sbjct: 418 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ----RGLFAAETLLGMCLDVCEGMAYL 473

Query: 257 HKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTS 316
            +   +H DLA RNC +  +  +KV D+G+      + Y  +   K FP++W +PE V S
Sbjct: 474 EEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTK-FPVKWASPE-VFS 531

Query: 317 FQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLE 376
           F      +  +  S++WS GV +WE+F     PY N SN +V+  +      +L KP+L 
Sbjct: 532 F------SRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI--STGFRLYKPRLA 583

Query: 377 QPYSDRWYEVLQFCWLS-PEKRPAAEDVHRLL 407
              S   Y+++  CW   PE RPA   + R L
Sbjct: 584 ---STHVYQIMNHCWKERPEDRPAFSRLLRQL 612


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  135 bits (340), Expect = 3e-31
 Identities = 89/282 (31%), Positives = 144/282 (51%), Gaps = 23/282 (8%)

Query: 131 QVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYY 190
           ++ R  +  ++E+G+G FG V LG+      VA  ++KE   S     +D F +  +   
Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMS-----EDEFFQEAQTMM 465

Query: 191 ILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVA 250
            L HP +++  G C +  P  +V E+   G L  YLRS   H +G   + LL+ M  +V 
Sbjct: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS---HGKGLEPSQLLE-MCYDVC 521

Query: 251 AGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTA 310
            G+A +    F+H DLA RNC +  DL VKV D+G+      + Y+ +   K FP++W+A
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTK-FPVKWSA 580

Query: 311 PELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKL 370
           PE+   F+        +  S++W+ G+ +WE+F    QPY    N  V+ +V   +  +L
Sbjct: 581 PEVFHYFK-------YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV--SQGHRL 631

Query: 371 PKPQLEQPYSDRWYEVLQFCWLS-PEKRPAAEDVHRLLTYLR 411
            +P L    SD  Y+++  CW   PEKRP  + +   +  LR
Sbjct: 632 YRPHLA---SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLR 670


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  135 bits (340), Expect = 3e-31
 Identities = 89/282 (31%), Positives = 144/282 (51%), Gaps = 23/282 (8%)

Query: 131 QVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYY 190
           ++ R  +  ++E+G+G FG V LG+      VA  ++KE   S     +D F +  +   
Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMS-----EDEFFQEAQTMM 465

Query: 191 ILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVA 250
            L HP +++  G C +  P  +V E+   G L  YLRS   H +G   + LL+ M  +V 
Sbjct: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS---HGKGLEPSQLLE-MCYDVC 521

Query: 251 AGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTA 310
            G+A +    F+H DLA RNC +  DL VKV D+G+      + Y+ +   K FP++W+A
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTK-FPVKWSA 580

Query: 311 PELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKL 370
           PE+   F+        +  S++W+ G+ +WE+F    QPY    N  V+ +V   +  +L
Sbjct: 581 PEVFHYFK-------YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV--SQGHRL 631

Query: 371 PKPQLEQPYSDRWYEVLQFCWLS-PEKRPAAEDVHRLLTYLR 411
            +P L    SD  Y+++  CW   PEKRP  + +   +  LR
Sbjct: 632 YRPHLA---SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLR 670


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  133 bits (335), Expect = 1e-30
 Identities = 92/322 (28%), Positives = 164/322 (50%), Gaps = 30/322 (9%)

Query: 110 VPNISLPAPSQFQPSVEGL-----KSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVAR 164
           +  +  PAP + +P+V G+     K ++ R  +    ++G G +G+V  G ++   S+  
Sbjct: 210 ITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEG-VWKKYSLT- 267

Query: 165 VIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKA 224
           V VK LK      E + FLK       ++HPN++Q +G C    P+ ++ EF   G+L  
Sbjct: 268 VAVKTLKEDT--MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLD 325

Query: 225 YLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDY 284
           YLR   E  R +   ++L  MA ++++ +  + K +F+H DLA RNC +  +  VKV D+
Sbjct: 326 YLR---ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADF 382

Query: 285 GIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFD 344
           G+      + Y      K FP++WTAPE +   +  +        S++W+ GV LWE+  
Sbjct: 383 GLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSI-------KSDVWAFGVLLWEIAT 434

Query: 345 NAAQPYSNLSNLDVLNQV--IRERDTKLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAE 401
               PY  +     L+QV  + E+D ++ +P   +   ++ YE+++ CW  +P  RP+  
Sbjct: 435 YGMSPYPGID----LSQVYELLEKDYRMERP---EGCPEKVYELMRACWQWNPSDRPSFA 487

Query: 402 DVHRLLTYLRLQSQRDSEVDFE 423
           ++H+    +  +S    EV+ E
Sbjct: 488 EIHQAFETMFQESSISDEVEKE 509


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  133 bits (335), Expect = 1e-30
 Identities = 92/322 (28%), Positives = 164/322 (50%), Gaps = 30/322 (9%)

Query: 110 VPNISLPAPSQFQPSVEGL-----KSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVAR 164
           +  +  PAP + +P+V G+     K ++ R  +    ++G G +G+V  G ++   S+  
Sbjct: 229 ITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEG-VWKKYSLT- 286

Query: 165 VIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKA 224
           V VK LK      E + FLK       ++HPN++Q +G C    P+ ++ EF   G+L  
Sbjct: 287 VAVKTLKEDT--MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLD 344

Query: 225 YLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDY 284
           YLR   E  R +   ++L  MA ++++ +  + K +F+H DLA RNC +  +  VKV D+
Sbjct: 345 YLR---ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADF 401

Query: 285 GIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFD 344
           G+      + Y      K FP++WTAPE +   +  +        S++W+ GV LWE+  
Sbjct: 402 GLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSI-------KSDVWAFGVLLWEIAT 453

Query: 345 NAAQPYSNLSNLDVLNQV--IRERDTKLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAE 401
               PY  +     L+QV  + E+D ++ +P   +   ++ YE+++ CW  +P  RP+  
Sbjct: 454 YGMSPYPGID----LSQVYELLEKDYRMERP---EGCPEKVYELMRACWQWNPSDRPSFA 506

Query: 402 DVHRLLTYLRLQSQRDSEVDFE 423
           ++H+    +  +S    EV+ E
Sbjct: 507 EIHQAFETMFQESSISDEVEKE 528


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
           a precursor [Homo sapiens]
          Length = 839

 Score =  133 bits (335), Expect = 1e-30
 Identities = 86/304 (28%), Positives = 148/304 (48%), Gaps = 40/304 (13%)

Query: 132 VARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPK--EQDTFLKNGEPY 189
           + R  +   +E+G G FGKV L E Y  +     ++  +KA  +P    +  F +  E  
Sbjct: 533 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL 592

Query: 190 YILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRS-----------EQEHMRGDSQ 238
             LQH +I++  G C +  P ++VFE+   GDL  +LR+           +    +G+  
Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELG 652

Query: 239 TMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDY--- 295
              +  +A ++A+G+  +   HF+H DLA RNC + ++L VK+GD+G+    Y  DY   
Sbjct: 653 LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRL 712

Query: 296 -----------IETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFD 344
                       E     + P+RW  PE   S   R  T +    S++WS GV LWE+F 
Sbjct: 713 FNPSGNDFCIWCEVGGHTMLPIRWMPPE---SIMYRKFTTE----SDVWSFGVILWEIFT 765

Query: 345 NAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAEDV 403
              QP+  LSN +V+  + + R  + P+   ++      Y+V+  CW   P++R   +++
Sbjct: 766 YGKQPWFQLSNTEVIECITQGRVLERPRVCPKEV-----YDVMLGCWQREPQQRLNIKEI 820

Query: 404 HRLL 407
           +++L
Sbjct: 821 YKIL 824


>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
           precursor [Homo sapiens]
          Length = 943

 Score =  132 bits (333), Expect = 2e-30
 Identities = 95/326 (29%), Positives = 149/326 (45%), Gaps = 30/326 (9%)

Query: 98  SVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIY 157
           S  +P     ++ P+  +  P   Q     LK +++  ++ +++E+G   FGKV  G ++
Sbjct: 435 SASTPQRRQLMASPSQDMEMPLINQHKQAKLK-EISLSAVRFMEELGEDRFGKVYKGHLF 493

Query: 158 ---TGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVF 214
               G     V +K LK  A    ++ F         LQHPN++  +G   +  P  ++F
Sbjct: 494 GPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIF 553

Query: 215 EFCDLGDLKAYLRSEQEHM----RGDSQTML-------LQRMACEVAAGLAAMHKLHFLH 263
            +C  GDL  +L     H       D +T+           +  ++AAG+  +   H +H
Sbjct: 554 SYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVH 613

Query: 264 SDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLT 323
            DLA RN  +   LNVK+ D G+    Y  DY +     + P+RW APE +       + 
Sbjct: 614 KDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAI-------MY 666

Query: 324 ADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRW 383
              +  S+IWS GV LWE+F    QPY   SN DV+ ++IR R   LP P         W
Sbjct: 667 GKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVV-EMIRNRQV-LPCPD----DCPAW 720

Query: 384 -YEVLQFCWLS-PEKRPAAEDVHRLL 407
            Y ++  CW   P +RP  +D+H  L
Sbjct: 721 VYALMIECWNEFPSRRPRFKDIHSRL 746


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  130 bits (326), Expect = 1e-29
 Identities = 87/283 (30%), Positives = 140/283 (49%), Gaps = 23/283 (8%)

Query: 129 KSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEP 188
           K ++    L +++E+G+G FG V LG+      VA   +K ++  A  +E   F++  + 
Sbjct: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVA---IKAIREGAMCEED--FIEEAKV 416

Query: 189 YYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACE 248
              L HP ++Q  G C +  P  +V EF + G L  +LR  Q H   D    +L  M  +
Sbjct: 417 MMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRD----VLLSMCQD 472

Query: 249 VAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRW 308
           V  G+  + +  F+H DLA RNC ++    VKV D+G+      + Y  +   K FP++W
Sbjct: 473 VCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAK-FPVKW 531

Query: 309 TAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDT 368
             PE+          +  +  S++WS GV +WE+F     P+   +N +V+  V R    
Sbjct: 532 CPPEVFN-------YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGH-- 582

Query: 369 KLPKPQLEQPYSDRWYEVLQFCWL-SPEKRPAAEDVHRLLTYL 410
           +L +P+L   Y    YEV+  CW   PE RP+ ED+ R +  L
Sbjct: 583 RLYQPKLASNYV---YEVMLRCWQEKPEGRPSFEDLLRTIDEL 622


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.130    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,960,879
Number of Sequences: 37866
Number of extensions: 3591180
Number of successful extensions: 14913
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 288
Number of HSP's successfully gapped in prelim test: 621
Number of HSP's that attempted gapping in prelim test: 12698
Number of HSP's gapped (non-prelim): 2122
length of query: 1503
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1388
effective length of database: 13,892,928
effective search space: 19283384064
effective search space used: 19283384064
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.