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Search of human proteins with 33946313
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33946313 ninein isoform 4 [Homo sapiens]
(2096 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33946313 ninein isoform 4 [Homo sapiens] 4100 0.0
gi|33946321 ninein isoform 5 [Homo sapiens] 4020 0.0
gi|148536869 ninein isoform 2 [Homo sapiens] 3964 0.0
gi|148536871 ninein isoform 1 [Homo sapiens] 3894 0.0
gi|55749678 ninein-like [Homo sapiens] 424 e-118
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 225 3e-58
gi|21735548 centrosomal protein 2 [Homo sapiens] 212 3e-54
gi|148746195 trichohyalin [Homo sapiens] 208 4e-53
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 206 2e-52
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 204 1e-51
gi|71061468 centromere protein E [Homo sapiens] 200 1e-50
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 176 2e-43
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 176 2e-43
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 176 2e-43
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 176 2e-43
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 176 2e-43
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 176 2e-43
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 176 2e-43
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 176 2e-43
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 170 1e-41
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 169 3e-41
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 167 1e-40
gi|55770834 centromere protein F [Homo sapiens] 163 2e-39
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 160 2e-38
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 157 1e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 157 1e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 157 1e-37
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 155 3e-37
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 153 1e-36
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 153 1e-36
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 4100 bits (10633), Expect = 0.0
Identities = 2096/2096 (100%), Positives = 2096/2096 (100%)
Query: 1 MAEVTVPRVYVVFGIHCIMAKASSDVQVSGFHRKIQHVKNELCHMLSLEEVAPVLQQTLL 60
MAEVTVPRVYVVFGIHCIMAKASSDVQVSGFHRKIQHVKNELCHMLSLEEVAPVLQQTLL
Sbjct: 1 MAEVTVPRVYVVFGIHCIMAKASSDVQVSGFHRKIQHVKNELCHMLSLEEVAPVLQQTLL 60
Query: 61 QDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQ 120
QDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQ
Sbjct: 61 QDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQ 120
Query: 121 ESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQS 180
ESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQS
Sbjct: 121 ESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQS 180
Query: 181 GSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPD 240
GSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPD
Sbjct: 181 GSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPD 240
Query: 241 GTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRV 300
GTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRV
Sbjct: 241 GTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRV 300
Query: 301 FSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTK 360
FSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTK
Sbjct: 301 FSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTK 360
Query: 361 NSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERR 420
NSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERR
Sbjct: 361 NSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERR 420
Query: 421 NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA
Sbjct: 421 NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT
Sbjct: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
Query: 541 QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 600
QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG
Sbjct: 541 QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 600
Query: 601 SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 660
SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM
Sbjct: 601 SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 660
Query: 661 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH
Sbjct: 661 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
Query: 721 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV
Sbjct: 721 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
Query: 781 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ
Sbjct: 781 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
Query: 841 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER
Sbjct: 841 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
Query: 901 EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV 960
EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV
Sbjct: 901 EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV 960
Query: 961 LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR 1020
LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR
Sbjct: 961 LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR 1020
Query: 1021 LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1080
LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH
Sbjct: 1021 LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1080
Query: 1081 EQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQ 1140
EQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQ
Sbjct: 1081 EQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQ 1140
Query: 1141 VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW
Sbjct: 1141 VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED
Sbjct: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEV 1320
VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEV
Sbjct: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEV 1320
Query: 1321 KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV 1380
KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV
Sbjct: 1321 KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV 1380
Query: 1381 PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEEN 1440
PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEEN
Sbjct: 1381 PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEEN 1440
Query: 1441 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500
TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM
Sbjct: 1441 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500
Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEM 1560
MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEM
Sbjct: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEM 1560
Query: 1561 WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL 1620
WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL
Sbjct: 1561 WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL 1620
Query: 1621 TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1680
TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ
Sbjct: 1621 TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1680
Query: 1681 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS
Sbjct: 1681 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800
LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ
Sbjct: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800
Query: 1801 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ 1860
EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ
Sbjct: 1801 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ 1860
Query: 1861 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920
ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ
Sbjct: 1861 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920
Query: 1921 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPH 1980
FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPH
Sbjct: 1921 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPH 1980
Query: 1981 AWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT 2040
AWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT
Sbjct: 1981 AWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT 2040
Query: 2041 VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH 2096
VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH
Sbjct: 2041 VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH 2096
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 4020 bits (10425), Expect = 0.0
Identities = 2056/2061 (99%), Positives = 2057/2061 (99%)
Query: 36 QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95
Q +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 30 QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89
Query: 96 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155
CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 90 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149
Query: 156 QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215
QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 150 QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209
Query: 216 ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275
ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 210 ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269
Query: 276 MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335
MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 270 MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329
Query: 336 DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395
DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 330 DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389
Query: 396 LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 390 LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449
Query: 456 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 450 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
Query: 516 NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575
NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 510 NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569
Query: 576 LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635
LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 570 LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629
Query: 636 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695
EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 630 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689
Query: 696 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755
HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749
Query: 756 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815
WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 810 RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
Query: 876 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935
AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 870 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
Query: 936 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 996 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 990 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109
Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169
Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
Query: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349
Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409
Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469
Query: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535
ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529
Query: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709
Query: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775
EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
Query: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835
NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829
Query: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895
HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889
Query: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
Query: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015
QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009
Query: 2016 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPG 2075
HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPG
Sbjct: 2010 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPG 2069
Query: 2076 HLCSPTSHSSFNSSFTSLYCH 2096
HLCSPTSHSSFNSSFTSLYCH
Sbjct: 2070 HLCSPTSHSSFNSSFTSLYCH 2090
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 3964 bits (10281), Expect = 0.0
Identities = 2030/2036 (99%), Positives = 2032/2036 (99%)
Query: 36 QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95
Q +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 30 QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89
Query: 96 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155
CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 90 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149
Query: 156 QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215
QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 150 QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209
Query: 216 ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275
ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 210 ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269
Query: 276 MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335
MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 270 MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329
Query: 336 DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395
DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 330 DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389
Query: 396 LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 390 LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449
Query: 456 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 450 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
Query: 516 NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575
NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 510 NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569
Query: 576 LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635
LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 570 LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629
Query: 636 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695
EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 630 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689
Query: 696 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755
HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749
Query: 756 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815
WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 810 RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
Query: 876 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935
AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 870 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
Query: 936 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 996 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 990 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109
Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169
Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
Query: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349
Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409
Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469
Query: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535
ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529
Query: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709
Query: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775
EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
Query: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835
NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829
Query: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895
HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889
Query: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
Query: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015
QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009
Query: 2016 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ+
Sbjct: 2010 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
Score = 77.4 bits (189), Expect = 1e-13
Identities = 274/1466 (18%), Positives = 568/1466 (38%), Gaps = 217/1466 (14%)
Query: 704 EEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 763
+EE + + + H + + ++E E + R + W EEK++
Sbjct: 130 DEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQE 189
Query: 764 LTQELE-----QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 818
+ ++L ++++L S+ E++ L+ + E+LE+ L T
Sbjct: 190 VCEDLGITRDGHLNRKKLVSICEQYGLQNVD--GEMLEEVFHNLDPDG----------TM 237
Query: 819 QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECA-E 877
+E F + + +S S YRQ + L Q +E + +T
Sbjct: 238 SVEDFFYG----LFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFR 293
Query: 878 AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ----DLEDLRNVSE 933
L + + ++ T + E +E + Q++L+ L+ N++E
Sbjct: 294 VFSCLDDGMGHASVERILDTWQEEGIENS------------QEILKALDFSLDGNINLTE 341
Query: 934 TQQSLLSDQILELKSSHKRELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 992
+L ++ ++ S H+ L + E+ +Q+ E+ ++ D ++ E +
Sbjct: 342 LTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR---EKEKLRSDLDKAEKLKS 398
Query: 993 LLAME-NIHKATCETADRERA-----EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIG 1046
L+A E + H A E + E I+ L++++++ ++ Q G
Sbjct: 399 LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI---------LQQAG 449
Query: 1047 EEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP 1106
++ +E + + + E + + + L E + EN + E L +LQ+
Sbjct: 450 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN-- 507
Query: 1107 GLVMSSCLDEPATEFFGNT-AEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDLGS 1163
L+ E FG+ E FLQ+ R Q+ R VL D D+ +L
Sbjct: 508 -------LENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560
Query: 1164 -TGTSSVQRQEVKIEESEA------------------------SVEGFSELENSEETRTE 1198
V R +K SE S+E +E +E
Sbjct: 561 YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620
Query: 1199 S-----WELKNQISQLQEQLMMLCADCDRASEK-KQDLLFDVSVLKKKLKMLERIPEASP 1252
EL++++ ++QL C +A E KQ + L+K++ L+
Sbjct: 621 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ 680
Query: 1253 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1312
+ ++ E C EE + + LE K E RLQ E++ +T+ S
Sbjct: 681 GQAAVLKEAHHEATCRHEEEKK---QLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 737
Query: 1313 LEKSYDEVKIE---NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI 1369
E+ + ++ E++ L L+ ++ S+V++ E E LE + +
Sbjct: 738 FEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE-KHQREL 796
Query: 1370 LQLNQTLE-ECVPRVRSVHHVIE-ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE 1427
+ + +E EC R + + +C++ + E Q LE E+ L QE
Sbjct: 797 QEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDL-------QE 849
Query: 1428 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDV 1487
+ R EE + +D+ Q A EL L+E ++ K +L +++++
Sbjct: 850 QQR-------EEKSQWEFEKDELTQECAEAQEL------LKETLKREKTTSLVLTQEREM 896
Query: 1488 LSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISN 1547
L E+ K ++ + + ++ Q +E LR SE Q S E+ + ++ +
Sbjct: 897 L-----EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 951
Query: 1548 LKLGTLNGSQEEMW-QKTETVKQENAAV-QKMVENLKKQISELKIKNQQLDLENTELSQK 1605
++ G+ E++ Q+ E ++ E+ Q+M+ L + K + D E E+S +
Sbjct: 952 EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1011
Query: 1606 NSQNQEKLQELNQRLTEML-----CQ---KEKEPGNSALEEREQEKFNLKEELERCKVQS 1657
S+ Q K++E+ Q + + CQ +E+ G+ AL +Q + L+E + V
Sbjct: 1012 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGD---VLL 1068
Query: 1658 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEK 1717
S + +A VK+ T I + + L K LE + C D + + E
Sbjct: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQK--LEPGLVMSSCLD-EPATEFFGNTAEQTEP 1125
Query: 1718 LLKEKEALSEELNSCVDKLAKSSLLEHRI--------ATMKQEQKSWEHQSASLK--SQL 1767
L++ ++++ + S L + + +++++++ E AS++ S+L
Sbjct: 1126 FLQQNR--TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1183
Query: 1768 VASQE---KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824
S+E + L++ + + Q+ + +D ++K+ L +V L K+L+
Sbjct: 1184 ENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML---ER 1240
Query: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVR 1884
PE + L+ R + D L E + + + +E L+ + T AE+ +++++
Sbjct: 1241 IPEASPKYKLLYEDVSREN----DCLQEELRMMETRYDEALENNKELT-AEVFRLQDELK 1295
Query: 1885 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1944
++E + LSL++ D+ + E N V ++ ++L+
Sbjct: 1296 KMEE------------------VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQE 1337
Query: 1945 IHLEN-------EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
++ L+ +++ D ++++ P ++ +Q+
Sbjct: 1338 SVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE------- 1390
Query: 1998 EQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK----- 2052
Q+L+ QLL E++ H L Q Q++ ++ + K
Sbjct: 1391 NQYLEGNTQLL--EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448
Query: 2053 -----LKLVKRLLQEKVNQLKEQVSL 2073
L+L K LQE +LKE+V++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTI 1474
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 3894 bits (10099), Expect = 0.0
Identities = 1992/1997 (99%), Positives = 1993/1997 (99%)
Query: 36 QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95
Q +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 30 QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89
Query: 96 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155
CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 90 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149
Query: 156 QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215
QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 150 QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209
Query: 216 ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275
ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 210 ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269
Query: 276 MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335
MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 270 MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329
Query: 336 DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395
DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 330 DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389
Query: 396 LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 390 LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449
Query: 456 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 450 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509
Query: 516 NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575
NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 510 NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569
Query: 576 LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635
LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 570 LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629
Query: 636 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695
EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 630 EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689
Query: 696 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755
HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 690 HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749
Query: 756 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815
WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 810 RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
Query: 876 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935
AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 870 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
Query: 936 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 996 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 990 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109
Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169
Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229
Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289
Query: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349
Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409
Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469
Query: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535
ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529
Query: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649
Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709
Query: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775
EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
Query: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835
NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829
Query: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895
HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889
Query: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949
Query: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015
QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009
Query: 2016 HLQEELENRTSETNTPQ 2032
HLQEELENRTSETNTPQ
Sbjct: 2010 HLQEELENRTSETNTPQ 2026
Score = 139 bits (350), Expect = 3e-32
Identities = 342/1663 (20%), Positives = 669/1663 (40%), Gaps = 323/1663 (19%)
Query: 448 EQILQQAGKQRLELEQEIEKA---KTEENYIRDRLALSLKENSRLENELLENAEKLAEYE 504
E+IL ++ +E QEI KA + N L L+L EN L + + LA ++
Sbjct: 308 ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL-ENELLVTKNSIHQAALASFK 366
Query: 505 NLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 564
L ++ V+ EK E+L ++ E+ ++ +VD+ + +
Sbjct: 367 AEIRHLLERVDQVVREK---------------EKLRSDLDKAEKLKSLMASEVDDHHAAI 411
Query: 565 EEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQH 624
E R LR L E + A + E ++ + +E E+ + +E +
Sbjct: 412 E--RRNEYNLR-KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENY 468
Query: 625 HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 684
RD L L+ ++ + E + + +K E +EN T+ L++ +L+N +AE
Sbjct: 469 IRDRLALSLKENSRLEN------ELLENAEKLAE-----YENLTNKLQR---NLENVLAE 514
Query: 685 LQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 744
G + + L+EE RLTQ + +
Sbjct: 515 KFGDL----------------DPSSAEFFLQEE------------------RLTQMRNEY 540
Query: 745 EREREGLQSSAWTEEKVRGLTQELEQFH-QEQLTSLVEKHTLEKEELRKELLEKHQRELQ 803
ER+ LQ ++V L ELE++ Q ++ L K++ +E +E + ++
Sbjct: 541 ERQCRVLQ------DQVDELQSELEEYRAQGRVLRLPLKNSPSEE------VEANSGGIE 588
Query: 804 EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ 863
ECN IEA E ++ ++ ++ +++ L+ + ++
Sbjct: 589 PEHGLGSEECNPLNMSIEA-------------ELVIEQMKEQHHRDICCLRLELEDKVRH 635
Query: 864 WEFEKDELTQECAEAQELLKE-------TLKRE----KTTSLVLTQEREMLEKTYKEHLN 912
+E + DE C +AQE +K+ TL+++ K L + +L++ + E
Sbjct: 636 YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695
Query: 913 SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-SEQLA 971
E++QL LE+ + + + L + L+ + + + ERE Q+ A +E+
Sbjct: 696 RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755
Query: 972 SQRLERLEMEHDQERQEMMSK-LLAMENIHKATCETADRE----RAEMSTEISRLQSKIK 1026
+ LE H ++ ++ K L E + K E RE R +M TE +R S+I+
Sbjct: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIE 815
Query: 1027 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1086
+ QS CQ + E + AL L+ G L+ EQ +E
Sbjct: 816 ---------AQFQSDCQKVTER---CESALQSLE---------GRYRQELKDLQEQQREE 854
Query: 1087 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1146
+ E L Q + + L + ++ + E E +++ V V R
Sbjct: 855 KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMV--VER 912
Query: 1147 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1206
+ +L DLED +R++ T S + Q ++++ S EL EE ++ +
Sbjct: 913 QQLLQDLED--LRNVSETQQSLLSDQILELKSSHKR-----ELREREEVLCQAGASEQLA 965
Query: 1207 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1266
SQ E+L M +++Q+++ KL +E I +K E RE
Sbjct: 966 SQRLERLEM------EHDQERQEMM-------SKLLAMENI------HKATCETADRER- 1005
Query: 1267 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1326
E++ E+ RLQ ++K+M++ T L+ + E E
Sbjct: 1006 --------------------AEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
Query: 1327 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1386
+ G + LQ+ E L E +L L + E+ V +
Sbjct: 1046 GD-------GALSLLQQG--------------EQLLEENGDVLLSLQRAHEQAVKENVKM 1084
Query: 1387 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1446
I +Q Q LE + + + T + Q + L++N T
Sbjct: 1085 ATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE--------QTEPFLQQNRTK--- 1133
Query: 1447 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1506
Q + + +++LE ++ R L T V++++V K EE +A +
Sbjct: 1134 QVEGVTRRHVLSDLEDDEV------RDLGSTGTSSVQRQEV-----KIEESEASVEGF-- 1180
Query: 1507 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1566
SE++ SE+ + E+ L+N+I+ L E+ + + ++++
Sbjct: 1181 --SELEN--------SEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1230
Query: 1567 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1626
+K++ KM+E + + + K+ + + EN L QE+L+ + R E L
Sbjct: 1231 LKKK----LKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETRYDEALEN 1279
Query: 1627 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1686
+ E E F L++EL++ + + T +S LE EVKI+ + L+
Sbjct: 1280 NK---------ELTAEVFRLQDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVLRLQ 1329
Query: 1687 DELEKMKQ--LHRCPDLSDFQQKISSV-LSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1743
++EK+++ + RC D ++ + ++ + + +L+ L++ L CV ++ +
Sbjct: 1330 GKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQ----LNQTLEECVPRVRS---VH 1381
Query: 1744 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE 1803
H I KQE + E + L+ ++ L T+Q R Q +
Sbjct: 1382 HVIEECKQENQYLEGNTQLLEK---VKAHEIAWLHGTIQT---------HQERPRVQNQV 1429
Query: 1804 ALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENE 1863
L++ L Q ++ ++ E+ + L ++L +++ L+ ++ L E E
Sbjct: 1430 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK-ERVTILVKQKDVLSHGEKE 1488
Query: 1864 R-LQTMVQNTKAELTHSREKVRQL--ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920
L+ M+ + + + ++KV L ES L +QE L+ E
Sbjct: 1489 EELKAMMHDLQITCSEMQQKVELLRYESEKL----------------QQENSILRNEITT 1532
Query: 1921 FQKEQSPANRKVSQMNSLEQEL----ETIHLENEGLKKKQVKLDEQLMEMQ------HLR 1970
+E S +N K+ +N ++E+ ET+ EN ++K L +Q+ E++ L
Sbjct: 1533 LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592
Query: 1971 STA-TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2029
+T + S + LQ L Q+ M+ +++ L + E+ +L+EELE +++
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1652
Query: 2030 TPQGNQEQLVTVMEERMIEVEQKLKLVKR---LLQEKVNQLKE 2069
T LV+ +E + EV+ + +V++ LL++++ ++K+
Sbjct: 1653 T-------LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
Score = 77.4 bits (189), Expect = 1e-13
Identities = 274/1466 (18%), Positives = 568/1466 (38%), Gaps = 217/1466 (14%)
Query: 704 EEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 763
+EE + + + H + + ++E E + R + W EEK++
Sbjct: 130 DEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQE 189
Query: 764 LTQELE-----QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 818
+ ++L ++++L S+ E++ L+ + E+LE+ L T
Sbjct: 190 VCEDLGITRDGHLNRKKLVSICEQYGLQNVD--GEMLEEVFHNLDPDG----------TM 237
Query: 819 QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECA-E 877
+E F + + +S S YRQ + L Q +E + +T
Sbjct: 238 SVEDFFYG----LFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFR 293
Query: 878 AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ----DLEDLRNVSE 933
L + + ++ T + E +E + Q++L+ L+ N++E
Sbjct: 294 VFSCLDDGMGHASVERILDTWQEEGIENS------------QEILKALDFSLDGNINLTE 341
Query: 934 TQQSLLSDQILELKSSHKRELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 992
+L ++ ++ S H+ L + E+ +Q+ E+ ++ D ++ E +
Sbjct: 342 LTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR---EKEKLRSDLDKAEKLKS 398
Query: 993 LLAME-NIHKATCETADRERA-----EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIG 1046
L+A E + H A E + E I+ L++++++ ++ Q G
Sbjct: 399 LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI---------LQQAG 449
Query: 1047 EEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP 1106
++ +E + + + E + + + L E + EN + E L +LQ+
Sbjct: 450 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN-- 507
Query: 1107 GLVMSSCLDEPATEFFGNT-AEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDLGS 1163
L+ E FG+ E FLQ+ R Q+ R VL D D+ +L
Sbjct: 508 -------LENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560
Query: 1164 -TGTSSVQRQEVKIEESEA------------------------SVEGFSELENSEETRTE 1198
V R +K SE S+E +E +E
Sbjct: 561 YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620
Query: 1199 S-----WELKNQISQLQEQLMMLCADCDRASEK-KQDLLFDVSVLKKKLKMLERIPEASP 1252
EL++++ ++QL C +A E KQ + L+K++ L+
Sbjct: 621 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ 680
Query: 1253 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1312
+ ++ E C EE + + LE K E RLQ E++ +T+ S
Sbjct: 681 GQAAVLKEAHHEATCRHEEEKK---QLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 737
Query: 1313 LEKSYDEVKIE---NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI 1369
E+ + ++ E++ L L+ ++ S+V++ E E LE + +
Sbjct: 738 FEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE-KHQREL 796
Query: 1370 LQLNQTLE-ECVPRVRSVHHVIE-ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE 1427
+ + +E EC R + + +C++ + E Q LE E+ L QE
Sbjct: 797 QEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDL-------QE 849
Query: 1428 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDV 1487
+ R EE + +D+ Q A EL L+E ++ K +L +++++
Sbjct: 850 QQR-------EEKSQWEFEKDELTQECAEAQEL------LKETLKREKTTSLVLTQEREM 896
Query: 1488 LSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISN 1547
L E+ K ++ + + ++ Q +E LR SE Q S E+ + ++ +
Sbjct: 897 L-----EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 951
Query: 1548 LKLGTLNGSQEEMW-QKTETVKQENAAV-QKMVENLKKQISELKIKNQQLDLENTELSQK 1605
++ G+ E++ Q+ E ++ E+ Q+M+ L + K + D E E+S +
Sbjct: 952 EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1011
Query: 1606 NSQNQEKLQELNQRLTEML-----CQ---KEKEPGNSALEEREQEKFNLKEELERCKVQS 1657
S+ Q K++E+ Q + + CQ +E+ G+ AL +Q + L+E + V
Sbjct: 1012 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGD---VLL 1068
Query: 1658 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEK 1717
S + +A VK+ T I + + L K LE + C D + + E
Sbjct: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQK--LEPGLVMSSCLD-EPATEFFGNTAEQTEP 1125
Query: 1718 LLKEKEALSEELNSCVDKLAKSSLLEHRI--------ATMKQEQKSWEHQSASLK--SQL 1767
L++ ++++ + S L + + +++++++ E AS++ S+L
Sbjct: 1126 FLQQNR--TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1183
Query: 1768 VASQE---KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824
S+E + L++ + + Q+ + +D ++K+ L +V L K+L+
Sbjct: 1184 ENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML---ER 1240
Query: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVR 1884
PE + L+ R + D L E + + + +E L+ + T AE+ +++++
Sbjct: 1241 IPEASPKYKLLYEDVSREN----DCLQEELRMMETRYDEALENNKELT-AEVFRLQDELK 1295
Query: 1885 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1944
++E + LSL++ D+ + E N V ++ ++L+
Sbjct: 1296 KMEE------------------VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQE 1337
Query: 1945 IHLEN-------EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
++ L+ +++ D ++++ P ++ +Q+
Sbjct: 1338 SVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE------- 1390
Query: 1998 EQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK----- 2052
Q+L+ QLL E++ H L Q Q++ ++ + K
Sbjct: 1391 NQYLEGNTQLL--EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448
Query: 2053 -----LKLVKRLLQEKVNQLKEQVSL 2073
L+L K LQE +LKE+V++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTI 1474
>gi|55749678 ninein-like [Homo sapiens]
Length = 1382
Score = 424 bits (1090), Expect = e-118
Identities = 289/794 (36%), Positives = 444/794 (55%), Gaps = 54/794 (6%)
Query: 41 ELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILS-----RTLSNEEHFQEPD 95
+LC L LE+ PVL QTLL ++ RV+F++FKE + +LS R + E
Sbjct: 34 QLCLKLHLEQQLPVLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESA 93
Query: 96 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHI----------- 144
S PKYV G K YGRRS PE ++ E V E + + SH+
Sbjct: 94 ASSAIPPKYVNGSKWYGRRSRPELCDAATEARRVP--EQQTQASLKSHLWRSASLESVES 151
Query: 145 -PAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGIT 203
+ + +E K ++E +EA+GQL+ W+ +D + Q SP D E +++ V E+LG+
Sbjct: 152 PKSDEEAESTKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVG 211
Query: 204 RDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTP 261
GHL+ ++L +C+ GLQ ++ E LE++F+ LD DG +S+E+F GLF + +L
Sbjct: 212 SSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLL 271
Query: 262 SASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIG-FRVFSCLDDGMGHASVERILDTW 320
+ST + K Q +ESG TTT+S++ S R+FS +DDG G A +++L W
Sbjct: 272 ESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMW 331
Query: 321 QEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLE 380
+EGI+N +EIL++LDFS+D +NL ELT AL+NEL+ +++ QAALA + E+ +
Sbjct: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
Query: 381 RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALK 440
+V+Q+ RE++K R DL++AEK E+DD H+ +E+ E ++ L++ Y+ER++ L+
Sbjct: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Query: 441 NELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 500
+E+ ERE +QA +QR LE ++ + + EE +R++L L+LKENSRL+ E++E EKL
Sbjct: 452 SEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKL 511
Query: 501 AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
++ E L KLQ++LE VL +K L+P SAE QEER + EYE +CR LQD+ DEL
Sbjct: 512 SDSERLALKLQKDLEFVLKDK---LEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDEL 568
Query: 561 QSELEEYRAQGRVLRLPL-KNSPSEEVEANSGGIEPEHGLG----SEECNPLNMSIEAEL 615
Q+ELE G RLP ++SPS + + GLG S N +SIE EL
Sbjct: 569 QAELE-----GLWARLPKNRHSPSWSPDGRRRQLP---GLGPAGISFLGNSAPVSIETEL 620
Query: 616 VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQI 675
++EQ+KE H++D LR +LE KV +YE+++ + +K +++M+Q E LE Q
Sbjct: 621 MMEQVKE-HYQD---LRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQK 676
Query: 676 SDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKA 735
+DL+ E+ E + + + T R E + Q+ L T L L+H L+
Sbjct: 677 ADLE-ELHEKSQEVIWGLQEQLQDTARGPEPE---QMGLAPCCTQALCGLALRHHSHLQQ 732
Query: 736 RLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELL 795
+A+A E GL + R LT ELE+ Q L + + E+L E
Sbjct: 733 IRREAEAELSGELSGLGAL----PARRDLTLELEEPPQGPL----PRGSQRSEQLELERA 784
Query: 796 EKHQRELQEGREKM 809
K Q E R +M
Sbjct: 785 LKLQPCASEKRAQM 798
Score = 67.8 bits (164), Expect = 1e-10
Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)
Query: 537 ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
ER + E+ ++ +++L + ++ QG RL L S EVEA E
Sbjct: 408 ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457
Query: 597 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
L E+ + ++E ++ Q +E R+ L L+ ++ +K++ E V +
Sbjct: 458 RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514
Query: 657 QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
+ + ++ L+ ++ E+ A+ + AAVLKE +E CR +++
Sbjct: 515 ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566
Query: 716 EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 775
EL+A L A + R S +W+ + G ++L
Sbjct: 567 ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604
Query: 776 LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 834
++ L + E EL E +++H ++L R ++ET+ N +I A
Sbjct: 605 ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649
Query: 835 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 894
L+ + +E KD+++ +R E S E +K +L + ++QE++ ++ + T+
Sbjct: 650 -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702
Query: 895 VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 952
E+ L + L + + LQ + R +E + S L L +
Sbjct: 703 GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759
Query: 953 ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1009
EL E + G+ SEQL +R +L+ ++R +M +S L E + A + D
Sbjct: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819
Query: 1010 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1064
E + + Q+ T L L+ GC GE + GDG S G
Sbjct: 820 PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876
Query: 1065 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1117
+ Q + + SR+Q ++ EP ++ L++P
Sbjct: 877 PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936
Query: 1118 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1171
A QT+P + + + + L ++++ R
Sbjct: 937 GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996
Query: 1172 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1226
Q+ + +E ++E + E R S Q++ Q A + K
Sbjct: 997 QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
Query: 1227 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1278
K D+ + L+ ++ LE+ + +L + +S EN L ++EL E+
Sbjct: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
Query: 1279 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1327
+D E L+ +KE EV Q++ K + ++ L L + + +NEE
Sbjct: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
Query: 1328 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1383
V + L +E++ S Q+ D LE L E L +L QTLEE +V
Sbjct: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233
Query: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1443
+ H + + + + + Q + V +A LH + E+ R + EE+
Sbjct: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287
Query: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503
L ++ + I L+ + LQE KLKE+ EK + ++ +
Sbjct: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332
Query: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1541
L + + + + ++ + ++++ +L ++ LN+
Sbjct: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
Score = 62.8 bits (151), Expect = 3e-09
Identities = 83/356 (23%), Positives = 152/356 (42%), Gaps = 68/356 (19%)
Query: 1733 VDKLAKSSLLEHRIATMKQEQKSWEHQSAS---------LKSQLVASQEKVQNLEDTVQN 1783
V+ + SL H + Q SW+ Q A+ L+ + + K+ +LED V+
Sbjct: 1014 VEVARRGSLPSH--LQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA 1071
Query: 1784 VNLQMSRMKSD---LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1840
+ + ++D +E LK ++ + ++L+ A +TH + Q+K
Sbjct: 1072 LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE--------STHDA----QRK 1119
Query: 1841 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1900
+ ++ ++++ E E L QN K +L+ +V QL HQ
Sbjct: 1120 EIE------VLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA-STHQAQ--- 1169
Query: 1901 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1960
E+ +++++ ++ ++ Q+ L ELE ++ E++ L+ +L
Sbjct: 1170 ------NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
Query: 1961 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQA-----CPMVPREQFLQLQRQL-LQAERIN 2014
+ L E Q A L+L Q QA +VP+++ +L R L LQ E+
Sbjct: 1224 QTLEESQDQVQGA---------HLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQAR 1274
Query: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
+ L + E E+ + EER+ E E LK ++ LLQEKV++LKEQ
Sbjct: 1275 RRLDAQREEH-----------EKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQ 1319
Score = 54.7 bits (130), Expect = 9e-07
Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)
Query: 387 REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 446
REK+ + + L E + + VD + + +L EE LKN+L +
Sbjct: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103
Query: 447 REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 506
R++ L+ A +EIE K ++ + + ++N +++L + ++ +
Sbjct: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158
Query: 507 TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 566
L ++ + E + + LTQ E R + DQ+ +L+ ELE
Sbjct: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
Query: 567 YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 626
+ + L+LP + ++ +E + ++ H L + Q + QH +
Sbjct: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249
Query: 627 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 682
++ RL +D+V + L ++ + ++ HE + E+++ + LKN
Sbjct: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306
Query: 683 AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 741
LQ + LKE + T K L +K L E HL L Q
Sbjct: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345
Query: 742 ASFEREREGLQSSAWTEEKVRGLTQ 766
A+ E++R + S EEKVR L +
Sbjct: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370
Score = 52.4 bits (124), Expect = 5e-06
Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)
Query: 699 ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 752
A+CR + E+ Q ++EE+ + + E +AR A + S E R G
Sbjct: 966 ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022
Query: 753 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
S +G QE QL + E T E K+ +E L++ +E
Sbjct: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075
Query: 813 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 872
+ R + + + +++E + L++ GR RQEL+ + ++ + E K +
Sbjct: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129
Query: 873 QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 926
+ C+E + L K+ L + L L QE + +EH V Q L Q LE
Sbjct: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185
Query: 927 DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 976
++ + Q SDQI +L+ S + E + L ++ Q A RL
Sbjct: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241
Query: 977 RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1029
+ + +H Q+R + +LL+++ + D +R E ++ + +++E +
Sbjct: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299
Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1086
+ ML +E+ E + LL ++L EN ++ +LQ E+ A K+
Sbjct: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357
Query: 1087 NVKMATEISRLQQRLQKLEP 1106
+ + ++ L + + ++ P
Sbjct: 1358 SRLLEEKVRALNKLVSRIAP 1377
Score = 48.9 bits (115), Expect = 5e-05
Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)
Query: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503
L D Q +A E +TK+ L R+ + T L+ +DV+ EK +L+
Sbjct: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079
Query: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1563
E R E +L +EN++L+N++
Sbjct: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102
Query: 1564 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1623
V+QE A + + +K+I LK ++ E L+++N +++L +LN R+ ++
Sbjct: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159
Query: 1624 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1683
QE + + E +V L SLE + + Q+ +Q+
Sbjct: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200
Query: 1684 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
L+ ELE + Q H+ L S+ Q + S L+ ++A ++ L V + +
Sbjct: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258
Query: 1741 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1797
+ E HR+ +++ EQ + + Q + QL A++E+V+ E ++N+ + + L+
Sbjct: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317
Query: 1798 TQQEKEALKQEVMSLHKQLQNA 1819
+Q ++ K +++ ++NA
Sbjct: 1318 -EQFEKNTKSDLLLKELYVENA 1338
Score = 38.1 bits (87), Expect = 0.091
Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)
Query: 799 QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 854
Q +Q GRE +++ + + + +E + D + +T +SA+Q Y QEL
Sbjct: 333 QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387
Query: 855 EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 910
Q+ + Q E+D+ Q+ A+ E +KE T + ++ + LE+ Y+E
Sbjct: 388 -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446
Query: 911 L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 959
L + + ER+ + R E +++ L +++ + R +E E
Sbjct: 447 LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506
Query: 960 VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1019
V+ + SE+LA + + LE + + ++LLA E A + + + ++
Sbjct: 507 VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566
Query: 1020 RLQSKIK 1026
LQ++++
Sbjct: 567 ELQAELE 573
Score = 37.0 bits (84), Expect = 0.20
Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)
Query: 1569 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1628
QE + Q VE L ++ + + ++ + N E ++ L++L ++ + L Q
Sbjct: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443
Query: 1629 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1688
+E + E E E+ E+ R + V L+AE + ++ + + +EN L+ E
Sbjct: 444 RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503
Query: 1689 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1731
+ EK+ R DL + + + +L+ E+ +LKE E +L
Sbjct: 504 IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563
Query: 1732 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1787
D+L LE A + + + S + QL A + N L
Sbjct: 564 RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621
Query: 1788 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1843
M ++K DLR + K ++E+ +L + + K S L Q+
Sbjct: 622 MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677
Query: 1844 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1898
L+ L + Q+++W E+LQ + + E Q L +H HL
Sbjct: 678 --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730
Score = 35.8 bits (81), Expect = 0.45
Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)
Query: 963 QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1008
Q EQLA+ ++ ++E+ +M +KLL +E++ +A + D
Sbjct: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091
Query: 1009 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1057
R R E+ S ++ KE++ S +V+ + LS
Sbjct: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151
Query: 1058 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1105
+LQ G++ EE+ + L ++ E+ V+ + + +I +L+ L+ L
Sbjct: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211
Query: 1106 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
P ++ L+E + G + LQ+ R + V H L L+ +
Sbjct: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271
Query: 1157 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1211
+ R ++Q E ++EE+E ++ L+ + E +E + L +
Sbjct: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331
Query: 1212 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1247
+L + A RA EK++ +L++K++ L ++
Sbjct: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371
Score = 35.8 bits (81), Expect = 0.45
Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)
Query: 362 SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 402
S HQA + I+ L + +++VVR + +KLR +L+ +E
Sbjct: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
Query: 403 KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 460
++L S +V H + + +L+++ ++R+A L L + EQ ++ QR E
Sbjct: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283
Query: 461 LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 520
E++++ TEE + L +E L E +KL E + ++N ++ L
Sbjct: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330
Query: 521 KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
K +L +A + + + E+Q R+L+++V L
Sbjct: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 225 bits (574), Expect = 3e-58
Identities = 414/2007 (20%), Positives = 843/2007 (42%), Gaps = 320/2007 (15%)
Query: 351 ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
+L E L+ + + +L+S++ + L+ + REK+KL+ L +++ +E+
Sbjct: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192
Query: 411 DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEK 467
+ ++ ++ + D EE + I+ L+ ++ ++++ + G +++ + + +
Sbjct: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL--RNGPMNVDVLKPLPQ 250
Query: 468 AKTEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 526
+ + + +EN + E ++E+ + E L +++R EN+L +
Sbjct: 251 LEPQAE------VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQ-ENLLKRCKETIQ 303
Query: 527 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR----AQGRVLRLPLKNSP 582
+E+ T + +E E LQ+Q+DE ELE+ + A+ L L+++
Sbjct: 304 S-------HKEQCTLLTSEKE----ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352
Query: 583 S--EEVEANSGGIEPEHGLGSEECNPLNMSIEAELV--IEQMKEQHHRDICCLRLELEDK 638
+ E++E + G + E E + A+L I+QM Q LR + E
Sbjct: 353 NLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE----LREQKEKS 408
Query: 639 VRHYEKQLDETVVSCKKAQE--------------NMKQRHENETHTLEKQISDLKNEIAE 684
R ++L++ + + +K +E +++ E E +L++++S +K E+ +
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 685 L-----QGQAAVLKEAHHEATCRHEEE-KKQLQVKLEEEKTHLQEKLRLQHEMELK-ARL 737
+ + Q A L++ H + R E+E K+LQ + E + ++ L LK ++
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 738 TQAQASFEREREGLQSSAW---TEEKVRGLTQELEQFHQE--QLTSLVEKHTLEKEELRK 792
+ Q S E LQ A +E K+R L QE E + +L S +EK E + K
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588
Query: 793 EL------------------LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 834
+L +EKH+ EL+ + + + + ++ Q+Q++ +K+ E+
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 835 CESALQSL----EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE---AQELLKETLK 887
CE ++L E ++ ++++ E+ E+ + E + L+ E +E A+ L+E L
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 888 REKTTSLVLTQEREMLEKTYKEH----LNSMVVERQQLLQDLEDLRNVSETQQSLL---S 940
K + + QE E K H ++S++ E + +Q E Q LL
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 941 DQILELKSSH----KRELREREEVLCQAGAS-------------------EQLASQRLER 977
D+ L+ +H + +++ E L QA A EQLA + +
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 978 LEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM 1037
L++E ER + ++ +E K C D + ++ + +L+ + EM+Q L+
Sbjct: 829 LDLE--TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
Query: 1038 LQSGCQVIGEEE--------VEGDGALSLLQQGE--------QLLEENGDVLLSLQRAHE 1081
+ G +E VE + + +++G+ Q L D + L +E
Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
Query: 1082 QAVKENVKMATEISR----LQQRLQK--LEPGLVMSSCLDEPATEFF------------- 1122
K K ++ + +Q+ L+K L+ + L+ A E
Sbjct: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
Query: 1123 --GNTAEQTEPF--LQQNRTKQVEGVTRRH--VLSDLEDDEVRDLGSTGTSSVQRQEVKI 1176
N+A ++ L+ N+ +Q+E +T H L+D+ + L + E+++
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066
Query: 1177 EESEASVEGFSE------LENSEETRTESWELKNQ-------ISQLQEQLMMLCADCDRA 1223
+E E V + E E + +W LK + +++LQEQL A +
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITW-LKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125
Query: 1224 SEKKQDLLFDVSVLK----KKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEEL 1272
++ + L + L+ K LK + E + K+L E+ R+ L EE
Sbjct: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185
Query: 1273 RMMETRYDEALENNKELTAEVFRLQDELKKMEEV----TETFLSLEKSYDEVKIENEELN 1328
+ +++ ++++ ++ ++ + E +L +EL ++ TE L K+ + + I + + N
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA-KTNELINISSSKTN 1244
Query: 1329 VLVLRL---QGKIEKLQESV-VQRCDCCLWEASLENLEIEPDG---NILQLNQTLEECVP 1381
++ R+ Q + K++E++ ++ C EA L L E + + Q LEE
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304
Query: 1382 RVRSVHHVIEECKQENQYLE---GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE 1438
+++S+ IE E + L+ GN Q K I L + + + + + E
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Query: 1439 ENTTLLGFQDK------HFQHQATIAELEL-----------EKTKLQELTRKLKERVTIL 1481
+ + + Q+ +++E E EK +L + + L +V L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424
Query: 1482 VKQK-----------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENS 1530
K+K + S +K+ + + H Q T E+Q ++EL E+ + ++ +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQH--QNTVKELQIQLELKSKEAYEKDEQIN 1482
Query: 1531 ILRNEITTLNE---------EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENL 1581
+L+ E+ N+ ED S ++ N E Q ++ E+ QK +E +
Sbjct: 1483 LLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE-I 1541
Query: 1582 KKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTE-----MLCQKEKEPGNSAL 1636
+ LK NQQ D+E+ EL QK QE +E + R+ E + + + + L
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL 1601
Query: 1637 EEREQE----KFNLKEELERCKVQSSTLVSSLEAELSEVK--IQTHIVQQENHLLKDELE 1690
E +++E ++K + E K L S A+L+E+K + I + LL E
Sbjct: 1602 ETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE 1661
Query: 1691 KMKQLHRCPD--LSDFQQKISS----VLSYNEKLLKEKEALSEELNSCVDKLAKSSLL-- 1742
K +Q + + LS+ K+ V EKL + + SE L V + AK+
Sbjct: 1662 KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL--IVPRSAKNVAAYT 1719
Query: 1743 -EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNL----EDTVQNVNLQMSRMKSDLRV 1797
+ + QK++E + + L+ L ++ +Q + E+TV + + +M + +
Sbjct: 1720 EQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSS-HFEMRCQYQERLI 1778
Query: 1798 TQQEKEALKQEVMSLHKQLQNA---GGKSWAPEIATH---PSGLHNQQKRLS----WDKL 1847
+ EA + E S+ LQ K ++ +A H G +N Q + + +D +
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDV 1838
Query: 1848 DHLMNEEQ---QLLWQENERLQTMVQNTKA-------ELTHSREKVRQL----------- 1886
+ E++ Q+L Q+ + L + + K ELT EK++ L
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898
Query: 1887 --ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS------- 1937
E N K + HL ++ E + L+ + ++E+ +++ ++
Sbjct: 1899 LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
Query: 1938 -LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQ-QQACPMV 1995
+QELE + E + +++++K +++ +E++H +T ++ QL Q +Q M
Sbjct: 1959 EHQQELEILKKEYDQEREEKIKQEQEDLELKH---NSTLKQLMREFNTQLAQKEQELEMT 2015
Query: 1996 PREQFLQLQRQLLQAERINQHLQE------ELENRTSETNTPQGNQEQLVTVMEERMIEV 2049
+E + Q ++AE + H +E ++ + + E+++ EE M
Sbjct: 2016 IKETINKAQE--VEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAK 2073
Query: 2050 EQKLKLVKRLLQEKVNQLKEQVSLPGH 2076
+ L+ LQ+K Q EQ PG+
Sbjct: 2074 VRDLQTQLEELQKKYQQKLEQEENPGN 2100
Score = 202 bits (514), Expect = 3e-51
Identities = 403/1935 (20%), Positives = 822/1935 (42%), Gaps = 350/1935 (18%)
Query: 268 RQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIEN 327
RQ+ L M+ + + R+ T R + +E+ L T Q+
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK----- 425
Query: 328 SQEILKALDFSLDGNINLTELT-----LALENELLVTKNSIHQAALASFKAEIRHLLERV 382
++E + L +D I E T ++L+ EL K + S + +I L
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL---- 481
Query: 383 DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 442
Q + EKE R + + +KL++ + A+E+ L+ E+ ++ AL+ E
Sbjct: 482 -QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE-E 539
Query: 443 LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN--AEKL 500
L +++ IL ++ + +L+QE E +T + L SL+EN +L + AEK
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 501 AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE- 559
+ +T ++++ + + K + L E+L ++ +Y+ + L+++ ++
Sbjct: 600 KHNKEITVMVEKHKTELESLK-------HQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
Query: 560 -----------LQSELEEYRAQGRVLRLPLKNSPSEEVEAN-SGGIEPEHGLGSEECNPL 607
Q+ +EE + + +L +K + E + + S ++ H L EE + L
Sbjct: 653 KETLLKDKEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKL-EEELSVL 710
Query: 608 -----NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KAQENMK 661
M E E +++ K H + + + E E ++ EK L + + + +E K
Sbjct: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
Query: 662 QRHENETHTLEKQISDLKNEIAELQGQAAVL------KEAHHEATCRHEEEKKQLQVKLE 715
E++ H +E +D+K ELQ +A L + A HE T +EE+ QLQ KL
Sbjct: 771 HLKEHQAH-VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
Query: 716 EEKTH--LQEKLRLQHEMELKARLTQAQASFEREREGLQ----SSAWTEEKVRGLTQ--- 766
+ +T L K + E + K T+ A + ++ +Q ++ E+KV+ LTQ
Sbjct: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889
Query: 767 -ELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM---ETECNRRTSQIEA 822
+LE ++EQ ++ +EKE + ++ E ++E++ +K+ E + + E
Sbjct: 890 SKLEDGNKEQ--EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947
Query: 823 QFQSD---CQKVTERCESALQSL-------EGRYRQELKDLQEQQREEKSQWEFEKDELT 872
+F++ +KV ++ + ++L E + ++EL++ + +++ Q+ + E+
Sbjct: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 873 QE----CAEAQELLKETLKREKTTSLVLTQEREMLE--KTYKEHLNSMVVERQQL--LQD 924
Q ++A L ET ++E+ SL RE+ + +++ LN E Q++ +Q
Sbjct: 1008 QANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066
Query: 925 LEDLRNVSETQQSLL---------SDQILELKSSHKRE---LREREEVLCQAGA------ 966
E + V+E +Q +L + +I LK ++ L E +E L Q A
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126
Query: 967 -SEQLASQRLERLEMEHDQERQE---MMSKLLAMENIHKATCETADRERAEMSTEISRLQ 1022
E LE+LE++ ++ +E + +L+ ++ + A+ ++ ++S S+L+
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML-------AEEDKRKVSELTSKLK 1179
Query: 1023 SKIKEMQQATSPLSMLQSGCQ--VIGEEEVEGDGALSL---LQQGEQLLEENGDVLLSLQ 1077
+ +E Q S + + +++ + A+ L ++ E LLE + L+++
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
Query: 1078 RAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNR 1137
+ A+ + IS Q R K++ L++ +C Q ++
Sbjct: 1240 SSKTNAI------LSRISHCQHRTTKVKEALLIKTCT-------VSELEAQLRQLTEEQN 1286
Query: 1138 TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN------ 1191
T + H L + ++++++ + + S V +E +E + SE E+
Sbjct: 1287 TLNISFQQATHQLEE-KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345
Query: 1192 ---SEE------TRTESWELKNQISQLQEQLMMLCADCDRA---SEKK------------ 1227
SE + E E K +IS L +QL L + SEK+
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405
Query: 1228 ---------QDLLFDVSVL-KKKLKMLERIPEASPKY----KLLYEDVSRENDCLQEELR 1273
QDL F V L K+K+ LE++ + S K+ K ++ + ++E
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465
Query: 1274 MMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNV-LVL 1332
+E + EA E ++++ L + K+ + L E D+ K+E +E N+ L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFD-----CLKGEMEDDKSKMEKKESNLETEL 1520
Query: 1333 RLQ-GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQ-LNQTLE----ECVPRVRSV 1386
+ Q +I +L++ + Q+ +EIE +L+ NQ + E V +++
Sbjct: 1521 KSQTARIMELEDHITQK-----------TIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569
Query: 1387 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1446
+ EE ++N+ E ++L +++ + ++T ++ N + + L
Sbjct: 1570 QELGEE--KDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625
Query: 1447 QDKHFQHQATIAELELEK-TKLQELTRKLKERVTILVKQKDVLSHGEKEEE-----LKAM 1500
+D+ LE E KL EL RK ++++ + KQ +LS E++EE ++
Sbjct: 1626 EDR----------LESESAAKLAELKRKAEQKIAAIKKQ--LLSQMEEKEEQYKKGTESH 1673
Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGT------LN 1554
+ +L E +++V +L EKL+ S+ ++ TL S N+ T
Sbjct: 1674 LSELNTKLQEREREVHIL---EEKLK---SVESSQSETLIVPRSAKNVAAYTEQEEADSQ 1727
Query: 1555 GSQEEMWQKTETVKQENAA-----VQKMVENLKKQIS---ELKIKNQQ--LDLENTELSQ 1604
G ++ +++ +V Q N +Q++ + ++ +S E++ + Q+ + LE+ E Q
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ 1787
Query: 1605 KNSQN-----QEKLQELNQRLTEMLCQK-EKEPGNSALEEREQEKFNLKEELERCKVQSS 1658
Q+ QE+L+E N++ + ++ Q EKE G + + Q K NL+
Sbjct: 1788 HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI----QAKQNLE----------- 1832
Query: 1659 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1718
+ ++ L E ++ I++Q K+K+L C L
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQ----------KIKELDSC-------------------L 1863
Query: 1719 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLE 1778
+++KE E+ K K L+ K + E+ KS LV Q K+
Sbjct: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV--QPKL---- 1917
Query: 1779 DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQ 1838
+ N+ Q + ++ L ++EK+ L +E++ L K L+ + H L
Sbjct: 1918 --LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE--------HQQELEIL 1967
Query: 1839 QKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE-----------KVRQLE 1887
+K ++ + + E++ L + N L+ +++ +L + K +++E
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027
Query: 1888 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV-SQMNSLEQELETIH 1946
+ LL HQ+ N + ++ LKR ++++ ++ +++ L+ +LE +
Sbjct: 2028 AELLESHQEETNQ--LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ 2085
Query: 1947 LENEGLKKKQVKLDEQ---------LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
KK Q KL+++ +ME+Q + T S D +L +Q+ R
Sbjct: 2086 ------KKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS----DSKLKEQEF-----R 2130
Query: 1998 EQFLQLQRQLLQAER 2012
EQ L+ +L + E+
Sbjct: 2131 EQIHNLEDRLKKYEK 2145
Score = 164 bits (415), Expect = 8e-40
Identities = 338/1662 (20%), Positives = 686/1662 (41%), Gaps = 296/1662 (17%)
Query: 606 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
P +M EAE ++ + + +E + Y + E V + + Q K+
Sbjct: 117 PSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176
Query: 666 NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL 725
+ + +K + + ELQ K E EE+ + + V L+ + + L+++L
Sbjct: 177 ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISV-LQTQVSLLKQRL 235
Query: 726 R--------------LQHEMELKARLTQAQASFE---------REREGLQSSAWTEEKVR 762
R L+ + E+ + ++ E + E LQ +E +
Sbjct: 236 RNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL 295
Query: 763 GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE-------KMETECNR 815
+E Q H+EQ T L T EKE L+++L E+ Q EL++ ++ K+ T+
Sbjct: 296 KRCKETIQSHKEQCTLL----TSEKEALQEQLDERLQ-ELEKIKDLHMAEKTKLITQLRD 350
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLE------GRYRQELKDLQEQQREEKSQWEFEKD 869
+ IE Q + E ++LE + R +K + Q E + Q E +
Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410
Query: 870 ELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR 929
+E +A ++T + + + ++ + +EKT +E S+ E ++ Q++ D+
Sbjct: 411 AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470
Query: 930 NVSETQQSLLSDQILELKSSHKREL-------------RERE--------------EVLC 962
S +QI +L+ H++EL RERE E L
Sbjct: 471 KKSS------EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK 524
Query: 963 QAGASEQLASQRLERLEMEH--------------DQERQEMMSKLLAME----------- 997
+ EQ S LE LE++ QE + +++L +E
Sbjct: 525 ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584
Query: 998 NIHKATCETADRERAEMSTEISRLQSK-------IKEMQQA--TSPLSMLQSGCQVIGEE 1048
N K + E+ + + EI+ + K +K Q A T L +L+ Q E+
Sbjct: 585 NQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEK 644
Query: 1049 EVEGDGALSLLQQGEQLLEENGDVLLS-LQRAHEQAVK-------ENVKMATEISRLQQR 1100
E Q+ E LL++ + + ++ +E+ ++ E +++E+S + +
Sbjct: 645 LRE-----KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699
Query: 1101 LQKLEPGL-VMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLS-----DLE 1154
KLE L V+ D+ E EQ + + +QV+ + + H +S
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQ-----KNHHQQQVDSIIKEHEVSIQRTEKAL 754
Query: 1155 DDEVRDLG-----------------STGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1197
D++ L + ++R E +++++ A ++ F +++ +T
Sbjct: 755 KDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT 814
Query: 1198 ESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLL 1257
+++E Q++QLQ++L+ L + +R KQ + +V KK + + + + L
Sbjct: 815 KAYE--EQLAQLQQKLLDL--ETERILLTKQ--VAEVEAQKK--DVCTELDAHKIQVQDL 866
Query: 1258 YEDVSRENDCLQEELRMMETRYDEALEN-------NKELTAE----VFRLQDELKKMEEV 1306
+ + ++N ++++++ + Y+ LE+ K++ E + ++++ KK E+
Sbjct: 867 MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926
Query: 1307 TETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD 1366
LS ++ D + I NEE + K+EK+++ + + +L+ ++ +
Sbjct: 927 LTQKLSAKE--DSIHILNEEYETKFKNQEKKMEKVKQKAKE------MQETLKKKLLDQE 978
Query: 1367 GNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE--IAWLHGTIQT 1424
+L + LE + +E ++E Q+ N ++LE +A+ I+ ++T
Sbjct: 979 A---KLKKELE---------NTALELSQKEKQF---NAKMLEMAQANSAGISDAVSRLET 1023
Query: 1425 HQ-ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1483
+Q E+ +V E ++ +K QA + E+ + +LQE KE+ +K
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ-EIHEIQLQE-----KEQEVAELK 1077
Query: 1484 QKDVLSHGEKEEE------LKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
QK +L EKEE LK T +E+Q++++ L Q+ + L+ +
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137
Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
L E D +LK T QE++ + +++ V ++ LK E + +
Sbjct: 1138 KL-EVDLNKSLKENTF--LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLK--------EE 1649
N L K+ + ++ +EL +L ++ C+K + + LE + E N+
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQL-DICCKKTE----ALLEAKTNELINISSSKTNAILSR 1249
Query: 1650 LERC-----KVQSSTL-----VSSLEAELSEVKIQTHIV----QQENHLLKDELEKMKQL 1695
+ C KV+ + L VS LEA+L ++ + + + QQ H L+++ ++K +
Sbjct: 1250 ISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSM 1309
Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKE---KEALSEELNSCVDKLAKS-SLLEHRIATMKQ 1751
+ I S+++ E L KE ++ + E SC+ +L K S + + MK+
Sbjct: 1310 ---------KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
Query: 1752 EQKSWEHQSASLKSQLVASQEKVQN------LEDTVQNVNLQMSRMKSDLRVTQQE---- 1801
E K + + +SL QL ++QN E + ++ Q K +L Q+
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420
Query: 1802 KEALKQEVMSLHKQLQNAGGK--SWAPEIATHPSGLHNQQKRLS-----WDKLDHLMNEE 1854
+ L +E +S +Q+ + K W + + + N K L K + +E+
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480
Query: 1855 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL----------LPKHQKHLNPSG-- 1902
LL +E ++ K E+ + K+ + ESNL + + + H+
Sbjct: 1481 INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE 1540
Query: 1903 -------TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
N +Q+ + K + Q Q K +++ E+++ T LEN+ K
Sbjct: 1541 IESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT--LENQVYSMK 1598
Query: 1956 QVKLDEQLMEMQHLR-STATPSPSPHAWDLQLLQQQACPMV-----PREQFLQLQRQLL- 2008
+L+ + E++H+ S + A + +L + A + ++ +++QLL
Sbjct: 1599 -AELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657
Query: 2009 QAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVE 2050
Q E + ++ E+ SE NT +E+ V ++EE++ VE
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Score = 162 bits (409), Expect = 4e-39
Identities = 328/1521 (21%), Positives = 631/1521 (41%), Gaps = 238/1521 (15%)
Query: 634 ELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLK 693
E ED V + + E ++ + E + + L L+ E +LQG +L
Sbjct: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG---ILS 179
Query: 694 EAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQ 752
++ ++ R E +++LQ+ ++ K HLQE+ E + + Q Q S ++R L+
Sbjct: 180 QSQDKSLRRIAELREELQMD-QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR--LR 236
Query: 753 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
+ + ++ L Q E + E+ K + +G +E
Sbjct: 237 NGPMNVDVLKPLPQL---------------------EPQAEVFTKEENPESDGEPVVEDG 275
Query: 813 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 872
+ +T + Q + + +RC+ +QS ++++ L EK + + DE
Sbjct: 276 TSVKTLETLQQRVKRQENLLKRCKETIQS----HKEQCTLLTS----EKEALQEQLDERL 327
Query: 873 QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 932
QE E +K+ EKT + ++ + L + ++ ++ E ++ + + +++
Sbjct: 328 QEL----EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKE-- 381
Query: 933 ETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 992
++I +L+S K+ + EE+ Q SE+ A + LE+ + Q+ +E K
Sbjct: 382 --------EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA-LSTAQKTEEARRK 432
Query: 993 LLA-MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
L A M+ K +T++ ER + E+SR++ ++ ++ + +S EE++
Sbjct: 433 LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------EEQI- 478
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
L + E+ L L + E+ +E +K+A E S+ + E S
Sbjct: 479 ----AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSS--- 1168
L+E + E R Q E T R + +LE + L S
Sbjct: 535 LALEELELQKKAILTESENKL----RDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590
Query: 1169 -----VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI--SQLQEQLMMLCADCD 1221
++ + E + + +ELE+ + + W K Q+ Q Q ++ L C+
Sbjct: 591 AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650
Query: 1222 RASE---KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1278
+ E K ++++F + + K LE++ D Q EL + +
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKL------------------DVKQTELESLSSE 692
Query: 1279 YDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1338
E L+ +L E+ L+D+ KM++ E + +K++ + ++++ I
Sbjct: 693 LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS-------------I 739
Query: 1339 EKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ 1398
K E +QR + L + I QL L+E ++ +E + + +
Sbjct: 740 IKEHEVSIQRTEKALKD------------QINQLELLLKERDKHLKEHQAHVENLEADIK 787
Query: 1399 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
EG Q + + Q++Q Q + ++++ Q Q +
Sbjct: 788 RSEGELQ--------QASAKLDVFQSYQSATHEQTK----------AYEEQLAQLQQKLL 829
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE-ELKAMMHDLQITCSEMQQKVEL 1517
+LE E+ L K+ + ++KDV + + + +++ +M L+ SEM+QKV+
Sbjct: 830 DLETERILL------TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 1518 LR--YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1575
L YES KL+ N L E++ N+ L G ++E+ E + Q+ +A +
Sbjct: 884 LTQVYES-KLEDGNKEQEQTKQILVEKE---NMILQMREGQKKEI----EILTQKLSAKE 935
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+ L ++ E K KNQ+ +E ++ QK + QE L+ ++L + + +KE N+A
Sbjct: 936 DSIHILNEEY-ETKFKNQEKKME--KVKQKAKEMQETLK---KKLLDQEAKLKKELENTA 989
Query: 1636 LEEREQEK-FNLKEELERCKVQS---STLVSSLEAELSE-VKIQTHIVQQE--------N 1682
LE ++EK FN K LE + S S VS LE E ++ T + ++E
Sbjct: 990 LELSQKEKQFNAK-MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
Query: 1683 HLLKDELEKMKQLHRC------PDLSDFQQKISSVLSYNEKLLKEKEALSEE-------L 1729
L + E+++++H ++++ +QKI E++ KE L EE L
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
Query: 1730 NSCVDKLAKSSLLEHRIATMKQEQKS-WEHQSASLKSQLVAS---QEKVQNLEDTVQNVN 1785
N ++L + S + +A + + K+ E L L + QE++ L+ +
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
Query: 1786 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLS 1843
++S + S L+ T +E ++LK +K L++ K + E+A + + L
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
Query: 1844 WDKLDHLMN---EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL--LPKHQKHL 1898
K + L+N + + Q K L V +LE+ L L + Q L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
Query: 1899 NPS---GTMNPTEQEKL---------SLKRECDQFQKE----QSPANRKVSQMNSLEQEL 1942
N S T E+E SL E + QKE Q A+ K S + L++EL
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 1943 ----ETIHLENEGLKKKQVK---LDEQLMEMQ-HLRSTATPSPSPHAWDLQLLQ--QQAC 1992
+ L E LK+K+V+ L +QL ++ L+++ + S A Q ++ C
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408
Query: 1993 PMVPREQFLQLQRQLLQAERINQHLQ-EELENRTSE-TNTPQGNQEQLVTVMEERMIEVE 2050
++ + Q L + L E+I+ Q ++ N+ SE Q Q ++E I++E
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
Query: 2051 QKLKLVKRLLQEKVNQLKEQV 2071
K K E++N LKE++
Sbjct: 1469 LKSKEAYE-KDEQINLLKEEL 1488
Score = 62.4 bits (150), Expect = 5e-09
Identities = 80/334 (23%), Positives = 142/334 (42%), Gaps = 61/334 (18%)
Query: 323 EGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERV 382
E + + E L+AL +DG TEL L E + + L++ +A+ L ++
Sbjct: 1875 EELTSKYEKLQALQ-QMDGRNKPTEL-LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932
Query: 383 DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 442
REK+KL ++ + +K +LR L +E+++ + LK E
Sbjct: 1933 AGAEREKQKLGKEIVRLQK----------------------DLRMLRKEHQQELEILKKE 1970
Query: 443 LRKEREQILQQAG-----KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENA 497
+ERE+ ++Q K L+Q + + T+ L +++KE E+ A
Sbjct: 1971 YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEV--EA 2028
Query: 498 EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 557
E L ++ TN+L + + AEK DL ++ + EE L E + R LQ Q+
Sbjct: 2029 ELLESHQEETNQLLKKI----AEKDDDLKRTAKRY---EEILDAREEEMTAKVRDLQTQL 2081
Query: 558 DELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVI 617
+ELQ + ++ Q EE N E L ++ + +++L
Sbjct: 2082 EELQKKYQQKLEQ-------------EENPGNDNVTIME--LQTQLAQKTTLISDSKLKE 2126
Query: 618 EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVV 651
++ +EQ H LED+++ YEK + T V
Sbjct: 2127 QEFREQIHN--------LEDRLKKYEKNVYATTV 2152
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 212 bits (540), Expect = 3e-54
Identities = 399/1914 (20%), Positives = 799/1914 (41%), Gaps = 286/1914 (14%)
Query: 357 LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA 416
L ++ + +A L E+ LL + + + EK+ L + ++ +E+ +H A+
Sbjct: 270 LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329
Query: 417 IERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQR-LELEQEIEKAKTEENYI 475
+ R + L + K+ + + +E + I Q +G + LEL+ I ++ +Y
Sbjct: 330 LSRNAQEEKLSLQQVIKD----ITQVMVEEGDNIAQGSGHENSLELDSSI---FSQFDYQ 382
Query: 476 RDRLALSLKEN--SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 533
AL+L + +R + + ++LA + N LQ ++ +
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ--------QQHDQWEEEGKALR 434
Query: 534 LQEERLTQMRNEYERQCRVLQDQVDELQSE-------LEEYRAQGRVLRLPLKNSPSEEV 586
+ ++LT R+ Q LQ +VD L E EE R Q VL V
Sbjct: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494
Query: 587 EANSGGIEPEHGLGSEECNPLNMSI-------EAELVIEQMKEQHHRDICCLRLELEDKV 639
E G + G E+ L++++ E + +E + + ++ LR LE
Sbjct: 495 ELQLQG-DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS- 552
Query: 640 RHYEKQL-----DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ-------- 686
H E +L E + +A++++ + +E +TL+ +++DL+ +L
Sbjct: 553 -HLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEALAL 610
Query: 687 -----GQAAVLKEAHHEATCRH----EEEKKQLQVKLE----------EEKTHLQEKLRL 727
Q + E +++ C E+ + LQV L E+ THL+ +L+
Sbjct: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
Query: 728 QHE--MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ-------LTS 778
E EL+A L Q E ++ L S +E T +LEQ HQE +
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEVLARA 727
Query: 779 LVEKHTLEKE----ELRKELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTE 833
+ EK L +E E+R + +E+ +++L E + + + +S EAQ Q+ +VT+
Sbjct: 728 VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
Query: 834 -RCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 889
+ E +Q++ + + E++ L+ + E+SQ E E+D ++ A+A++ K L+++
Sbjct: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
Query: 890 KTT-SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKS 948
K + Q RE EK H +Q+L + LE L + +EL+
Sbjct: 848 KAAHEKEVNQLREKWEKERSWH-------QQELAKALESLER-----------EKMELEM 889
Query: 949 SHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD 1008
K + E E + Q A L ++++E ++ER ++ LL + + +
Sbjct: 890 RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
Query: 1009 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE-EEVEGDGALSLLQQGEQLLE 1067
R R +M + K+KE + + LQ + + E D +L ++ LL+
Sbjct: 950 RLRQDMKVQ------KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 1068 ENGDVLLSL-------------QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS--- 1111
+ D+ + QR EQ V+E ++ E +R+Q+ L++ + L +S
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
Query: 1112 -------------------SCLDEPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRR-H 1148
S L + E G E Q E Q+ + K+ + + +
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 1149 VLSDLEDDEVRD------LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1202
+L +LE + + L + + Q Q +++ +E+ +E + + +L
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
Query: 1203 KNQISQLQEQLMMLCADCDRAS------------EKKQDLLFDVSVLKKKLKMLERIPEA 1250
+ S LQ+ L +C S E Q+ + L L A
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 1251 SPKYKLLYEDV---SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL------- 1300
S +K L++D+ + D L+++++ +E R + ++ E+ LQ +L
Sbjct: 1243 SALHK-LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301
Query: 1301 -----------KKMEEVTETFLSLEKSYDEVKI-------ENEELNVLVLRLQGKIEKLQ 1342
++ E+ ET SL+ ++ E E L L ++E LQ
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQL-NQTLEECVPRVRSVHHVIEECKQENQYLE 1401
+VV+ LE ++ + L+L N+ +E R +++ E + + L+
Sbjct: 1362 AAVVEARAQASAAGILEE-DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Query: 1402 GNTQLLEKVKA---HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
N LL + A E+ L G IQ +++ +Q + + L + Q I
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
ELE ++ L+ L ++ER L Q++ + EK+ E + + + Q+ E+++K +++
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--ELEKKDQMI 1538
Query: 1519 RYESEKLQQ-ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ-ENAAVQK 1576
+ ++Q + ++ E L E++ ++ Q+++ ++ E ++ + A+
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTH 1592
Query: 1577 MVENLKKQISELKIKNQQL-DLE--NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGN 1633
+ +L+++ EL+ ++ Q+ DLE +T L+++ + ++++ +++ E+ Q++KE
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL--QRQKEHLT 1650
Query: 1634 SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI-----------QTHIVQQE- 1681
LE R+QE KE ++ + Q + LE +L ++K+ Q ++Q+
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 1682 ------NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDK 1735
+ + LE MK + L D ++++ + +L + K+ L ++L K
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
Query: 1736 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1795
+ ++SLL + Q E + L+ QL ++E+ + E ++Q+ Q+ + L
Sbjct: 1766 VGETSLL------LSQR----EQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRAL 1812
Query: 1796 RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH-----L 1850
QE EAL+QE Q + K+ A + A + H K + DH
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HMTLKERHGELQDHKEQARR 1870
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKH-----------LN 1899
+ EE + + + L+ ++ + +AE + + L+ + Q+H L
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
Query: 1900 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1959
+ +QE +L+ E Q + Q A R ++ +L++ L H +G K+Q L
Sbjct: 1931 AQAVLKERDQELEALRAE-SQSSRHQEEAAR--ARAEALQEALGKAHAALQG--KEQHLL 1985
Query: 1960 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2019
++ + STAT S A Q + R Q ++Q Q L+ + Q LQ+
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQ 2042
Query: 2020 ELENRTSETNTPQGNQEQLVTVMEERMIE--VEQKLKLVKRLLQEKVNQLKEQV 2071
L R E Q ++ L + +R+ E +++K L + +E++ L + V
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSV 2096
Score = 202 bits (515), Expect = 2e-51
Identities = 356/1733 (20%), Positives = 707/1733 (40%), Gaps = 269/1733 (15%)
Query: 353 ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 412
E E LV + + + L + + + + L E++ + KE L S L +A++ S++
Sbjct: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
Query: 413 HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQ---AGKQRLELEQEIEKAK 469
I+ + + E + + LK EL ER Q Q+ A +Q + EQE + A
Sbjct: 790 LEVQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844
Query: 470 TEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSS 529
++ ++ L+E + E E + ++LA+ + + LE L E+ +++
Sbjct: 845 EQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 530 AEFFLQEER------LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS 583
A+ +EER L QM+ E E++ L + + + Q EL + Q LR +K
Sbjct: 903 AQ--REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
Query: 584 EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCL----------RL 633
+E E G+ + EA+ +++ QH D+ L ++
Sbjct: 961 KEQETT--------GILQTQLQ------EAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
Query: 634 ELEDKVRHYEKQL----DETVVSCKKAQENMKQRHENET--HTLEKQISDLKNEIAELQG 687
+L+ +V + QL D + ++ QE +++ E LE++ + L + E +
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
Query: 688 QAAVLKEA----HHEATCRHEE------EKKQLQVKLEEEKTHLQEKLR--LQHEMELKA 735
+ VL+EA E + ++ E+K+L ++E + ++EK L E +L
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL-- 1124
Query: 736 RLTQAQASFEREREGLQSSAWTEE--------KVRGLTQELEQFHQEQ------------ 775
L + +AS E++ L++S W +E ++R +LE EQ
Sbjct: 1125 -LEELEASHITEQQ-LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
Query: 776 --LTSLVEKHTLEKEELRKEL------------LEKHQRELQE-----------GREKME 810
L S +++ E R EL LE Q + E +
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 811 TECNR------RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ---QREEK 861
+ ++ +T Q + QK+ ER ++ + + EL+DLQ Q +EEK
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT-EAEKSQVHTELQDLQRQLSQNQEEK 1301
Query: 862 SQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKTYK------EHLN 912
S+WE +++ L E E E L+ L+R + + ERE+L+ + EHL
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
Query: 913 SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE--LREREEVLCQAGASEQL 970
+ VVE + L T +S L + E++S +R L+E+ E+ G + Q
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
Query: 971 ASQRLERLEMEHDQERQEMMSKLLAMEN---IHKATCETADRERAEMSTEISRLQSKIKE 1027
L + E ++E + + ++ +E + KA E + + + E+ Q +I+E
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481
Query: 1028 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1087
+++ S L L Q E + L++ ++ + LE++ + + + E + E
Sbjct: 1482 LEKCRSVLEHLPMAVQ-------EREQKLTVQREQIRELEKDRE---TQRNVLEHQLLEL 1531
Query: 1088 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1147
K I + ++Q L+ LV CL E Q + + ++ + V
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
Query: 1148 HVLSDLED---------DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTE 1198
H+ DLE+ ++ DL S T + + + +E ++ E EL+ +E T+
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651
Query: 1199 SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1258
E ++Q LQ++ + + D +Q + + + + KL + ER E + + +L+
Sbjct: 1652 DLERRDQELMLQKERIQVLED----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707
Query: 1259 EDV------SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM-----EEVT 1307
E S+ E ++++ ++ +E +E E+ L+D+L++ +V
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1367
ET L L + E+ + ++L R QG+++ E SL++ E
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEA--REQGELK---------------EQSLQSQLDEAQR 1810
Query: 1368 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQTHQ 1426
+ Q +Q LE + E K++ L+G + +AH + HG +Q H+
Sbjct: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHK 1865
Query: 1427 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD 1486
E+ R + + E + ++ + +L E + ++ L+++ ++ +
Sbjct: 1866 EQARRLEEELAVEGRRVQALEE-------VLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
Query: 1487 VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1546
V + ++ L+A Q E Q++E LR ES+ + + R L E +
Sbjct: 1919 VETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 1547 NLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 1606
+ L G ++ + ++ E + A+ + +L + + + L ++ E+ ++
Sbjct: 1974 H---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030
Query: 1607 SQNQEKLQELNQRLT----EMLCQKEKEP------GNSALEEREQEKFNLKEELERCKVQ 1656
+ QE +Q+L Q L E+ Q+E+E E QEK NL +E E +++
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090
Query: 1657 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1716
S E +L+ + + I++ ++ LE + H+ + + K+ S+
Sbjct: 2091 GLHQ-SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL---EP 2146
Query: 1717 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1776
+L +E E L L E R +++ + A K+ + + QE
Sbjct: 2147 RLQRELERLQAALRQT----------EAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Query: 1777 LEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLHKQLQNAG------GKSWAPEI 1828
L+ +V + + R++ +L +T++ EKE L + +L + G G+ E
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256
Query: 1829 ATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLES 1888
P G+ Q R +L+HL +L +++
Sbjct: 2257 EPSPDGMEKQSWR---QRLEHLQQAVARL---------------------------EIDR 2286
Query: 1889 NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1941
+ L +H L T+ E+E+ LKRE + + S K + + +Q+
Sbjct: 2287 SRLQRHNVQLR--STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
Score = 195 bits (496), Expect = 3e-49
Identities = 373/1848 (20%), Positives = 765/1848 (41%), Gaps = 236/1848 (12%)
Query: 326 ENSQEILKALDF----SLDGNINLTELTLA--LENELLVTKNSIHQAALASFKAEIRHLL 379
E QE+L L+ SL I L E + LE ELL + + AALA + I L
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASE---VDDHHAAIERRNEYNLRKLD--EEYKE 434
+ + E LR+ K L +A + ++ +E N+ +++ E+ +
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
Query: 435 RIAALKNELRKEREQI----------LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 484
+ E K RE + LQ+A + EL+ ++ + E+ I+ +L+ S
Sbjct: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701
Query: 485 ENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN 544
+ +L + ++ E + + + E ++ EK A ++ + + + R
Sbjct: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK--------AALEVRLQAVERDRQ 753
Query: 545 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 604
+ Q + L + L+S L E + Q V+ + EV+ + E G C
Sbjct: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRC 810
Query: 605 NPLNMSIEAELVIEQMKEQHHRDICCLRLE----LEDKVRHYEKQLDETVVSCKKAQENM 660
L + E EQ ++ R + E LE + +EK++++ +K +
Sbjct: 811 LKLELDTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
Query: 661 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
+Q +LE++ +L+ + E Q + ++ E + E Q+Q++ E+E+
Sbjct: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
Query: 721 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
L E L ++ + L A ER R+ ++ E++ G+ Q Q Q +L
Sbjct: 930 LLETL-----LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 781 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
+H +++L L++ L + + ++ + SQ+ A Q D Q++ E+
Sbjct: 985 RQH---RDDL--AALQEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQ------ 1031
Query: 841 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
+++L++ QE R +K + E EK LT E ++ L L ++ S+ R
Sbjct: 1032 ----EVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKEQRL---LVLQEADSI-----R 1078
Query: 901 EMLEKTYKEHLNSMVVERQQLLQDLEDLR-NVSETQQSLLSDQ---ILELKSSHKRELRE 956
+ ++ + E+++L +E LR V E + L+ + + EL++SH E +
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + Q + QL +L + + + E ++ N +A +A++++
Sbjct: 1139 RASLWAQEAKAAQL------QLRLRSTESQLEALAAEQQPGNQAQA--------QAQLAS 1184
Query: 1017 EISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS- 1075
S LQ + + ++ LS + E + +GA SL ++G L + + + S
Sbjct: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Query: 1076 LQRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1133
L + H+ K T+ +R L+ ++QKLE L D A + +T Q L
Sbjct: 1245 LHKLHQDLWK------TQQTRDVLRDQVQKLEERLT-----DTEAEKSQVHTELQD---L 1290
Query: 1134 QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
Q+ ++ E ++ + + E+ +L T +S+Q + + E +G EL +
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGERELLQAA 1349
Query: 1194 ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK 1253
+ L Q+ LQ ++ A A ++DL S LK K + +E E +
Sbjct: 1350 KE-----NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 1254 YKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF-LS 1312
+ E + LQE L ++ E E + L ++ L+ + + + E L
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
Query: 1313 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1372
L+K EV ++ E++ L + + +E L +V +R + L ++ + Q+
Sbjct: 1465 LKKRNQEVDLQQEQIQELE-KCRSVLEHLPMAVQER---------EQKLTVQRE----QI 1510
Query: 1373 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ 1432
+ ++ + + H + E ++++Q +E ++ +K + ++
Sbjct: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE--------- 1561
Query: 1433 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK----DVL 1488
LEEN + Q K + + E ++ L LT L+ER L Q D+
Sbjct: 1562 ----LEENHHKMECQQKLIKELE--GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615
Query: 1489 SHG--------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLN 1540
SH E+++E+K+ ++ E+Q++ E L + E+ QE + + I L
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
Query: 1541 E---------EDSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
+ E+ + +KL L ++ M ++ E K + A + +E++K
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK--- 1728
Query: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA--LEEREQEK 1643
L +++++ ++E + ++ +LQEL +L + L ++ G ++ L +REQE
Sbjct: 1729 --LILRDKEKEVECQQ------EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLS 1702
L+++L+ + Q SL+++L E + QE L+ E ++ + Q R + +
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE-HRIATMKQEQKSWEHQSA 1761
D + L LKE+ ++ +L + +E R+ +++ +S
Sbjct: 1841 D---ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
Query: 1762 SLKSQLVASQEKV--QNLEDTVQNVNLQMSRMKSD--LRVTQQEKEALKQEVMSLHKQ-- 1815
+ L+A Q++ Q E V+ LQ S +++ L+ QE EAL+ E S Q
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957
Query: 1816 --------LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQT 1867
LQ A GK+ A L + S + + + +L+
Sbjct: 1958 AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017
Query: 1868 MVQNTKAELTHS----REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQK 1923
++ + E+ +E V+QL+ L + ++ + E+E+L K + Q+
Sbjct: 2018 ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE------LRHQQEREQLLEKSLAQRVQE 2071
Query: 1924 EQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWD 1983
+ + Q E+E+ +H L+ + +++++E++ + PH+
Sbjct: 2072 NMIQEKQNLGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 1984 LQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENR---------TSETNTPQGN 2034
+++Q+ + E LQ + + LQA + Q E+E R ++T +
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQA-ALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
Query: 2035 QEQLVTVMEERMIE-------VEQKLKLVKRLLQEKVNQLKEQVSLPG 2075
+++ ++ ++E ++ +L+L +R L+ KE++ PG
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALE------KERLHSPG 2231
Score = 139 bits (351), Expect = 2e-32
Identities = 327/1562 (20%), Positives = 642/1562 (41%), Gaps = 257/1562 (16%)
Query: 313 VERILDTWQEEGIENSQEILKALDF----SLDGNINLTE-------LTLALENELLVTKN 361
V ++ + W++E + QE+ KAL+ ++ + L E + E E ++
Sbjct: 855 VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
Query: 362 SIHQAALASFKAEIRHLLERVDQVVRE-------KEKLRSDLDKAEKLK-----SLMASE 409
++ Q L + K + LLE + Q +E E+LR D+ K +KLK ++ ++
Sbjct: 915 ALCQMQLETEKERV-SLLETLLQTQKELADASQQLERLRQDM-KVQKLKEQETTGILQTQ 972
Query: 410 VDDHHAAIE---RRNEYNLRKLDEEYKERI---AALKNELRKEREQILQQAGKQRLELEQ 463
+ + ++ R++ +L L EE + L+ ++ + Q++ Q QRL +EQ
Sbjct: 973 LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL-VEQ 1031
Query: 464 EI-EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENV---LA 519
E+ EK + + Y R + L +E + L L+E ++L + + Q+ L + +
Sbjct: 1032 EVQEKLRETQEYNRIQKELE-REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQ 1090
Query: 520 EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD-------ELQSELEEYRAQGR 572
E G+ SA+ L + + + ++ Q L ++++ +L++ L A+
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150
Query: 573 VLRLPLKNS------------PSEEVEANS------------------------------ 590
L+L L+++ P + +A +
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210
Query: 591 ---GGIEPEHGLGSE--ECNPLNMSIEAELVIEQM--------KEQHHRDICCLRLELED 637
G+EP+ + PL ++ AE V + K Q RD+ L D
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV------LRD 1264
Query: 638 KVRHYEKQLDETVVSCKKAQ---------------ENMKQRHENETHTLEKQISDLKNEI 682
+V+ E++L +T +K+Q + K + E + ++LE ++ +L +
Sbjct: 1265 QVQKLEERLTDT--EAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322
Query: 683 A--------------ELQGQAAVLKEAHHEATCRHE-------EEKKQLQVK--LEEEKT 719
A E QG+ +L+ A T + E E + Q LEE+
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382
Query: 720 HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
+ L+L++E E+++ +AQA E+ + +E + LTQ L + +E T
Sbjct: 1383 TARSALKLKNE-EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 780 VEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 838
+ LEK+ E++K LE +L++ ++++ + Q + Q C+ V E A
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ------QEQIQELEKCRSVLEHLPMA 1495
Query: 839 LQSLEGR---YRQELKDLQEQQREEKSQWEFEKDELTQ--ECAEAQELLKETLKREKTTS 893
+Q E + R+++++L++ + +++ E + EL + + E+Q + LK++ T
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555
Query: 894 LVLTQE-------REMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 946
L E E +K KE +R L DL S+ Q+ S QI +L
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA-QSSQIHDL 1614
Query: 947 KSSH---KRELRER-EEVLCQAGASEQLASQRLERLEMEHDQERQEMM------------ 990
+S REL+ER +EV Q E+L Q+ E L + ++ QE+M
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIEELQRQK-EHLTQDLERRDQELMLQKERIQVLEDQ 1673
Query: 991 ----SKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSGCQVI 1045
+K+L E++ + +R R E++T+ +Q + +E + + + L+ ++
Sbjct: 1674 RTRQTKILE-EDLEQIKLSLRERGR-ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 1046 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL- 1104
++E E + + + ++L ++ L L R + + EI LQQ+LQ+
Sbjct: 1732 RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791
Query: 1105 EPGLVMSSCLDEPATEFFGNTAEQTEPF--LQQNRTKQVEGVTRR------HVLSDLEDD 1156
E G + L E A++ + LQQ + +Q +G R + LE
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQ-QQAQGQEERVKEKADALQGALEQA 1850
Query: 1157 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET----RTESWELKNQISQLQEQ 1212
+ G +++ + E E +VEG ++ EE R ES E + + LQ+Q
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEG-RRVQALEEVLGDLRAESREQEKALLALQQQ 1909
Query: 1213 LMMLCADCDRASEKKQDLLFD-----VSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1267
CA+ + E + L D +VLK++ + LE + S + E +
Sbjct: 1910 ----CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965
Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSY-----DEVKI 1322
LQE L + AL+ ++ E L L+ + L +++ + ++I
Sbjct: 1966 LQEAL----GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021
Query: 1323 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLE-----NLEIEPDGNILQLNQTL- 1376
+ E+ LR Q +++LQ+++ QR + + E +L N++Q Q L
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081
Query: 1377 -EECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH--QERPRVQN 1433
E +R +H + E QL K EI L T Q + + P
Sbjct: 2082 QEREEEEIRGLHQSVRE-----------LQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 1434 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKER---VTILVKQKDVLSH 1490
+EE + L + Q + + L +T+ +E+ + K + +++ + V S
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
Query: 1491 GEKEEELKAMMHDLQITCSEMQQKVELLR--YESEKLQQENSILRNEITTLNEEDSISNL 1548
E L+A + + +Q ++EL R E E+L + E+ + E+ +
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ----GV 2246
Query: 1549 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1608
+LG ++G + E E + ++ +E+L++ ++ L+I +L N +L Q
Sbjct: 2247 QLGEVSGVEAE----PSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Query: 1609 NQEKLQELNQRLTEMLCQKEKEPGN-SALEEREQEKFNLKEELERCKVQSSTLVSSLEAE 1667
+ + ++L + E +A +Q+ K +C + V L+A+
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQ 2362
Query: 1668 LS 1669
L+
Sbjct: 2363 LT 2364
Score = 104 bits (259), Expect = 1e-21
Identities = 174/837 (20%), Positives = 364/837 (43%), Gaps = 101/837 (12%)
Query: 1281 EALENNKELTAEVFRLQDELKKME---EVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1337
EA E ++EL + Q +L+K E VTE L +S + NE+ ++ L+
Sbjct: 259 EAHERSQELIQ--LKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALRET 312
Query: 1338 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1397
+E L+ + + + EASL E ++ Q+ + + + + V ++ + EN
Sbjct: 313 VEILETNHTELME---HEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHEN 367
Query: 1398 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATI 1457
LE ++ + + + +++ R R Q + + L G Q+ +
Sbjct: 368 S-LELDSSIFSQFDYQDADKALTLVRSVLTRRR---QAVQDLRQQLAGCQE-------AV 416
Query: 1458 AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVEL 1517
L+ + + +E + L++R+ L ++D L+ DLQ + ++ EL
Sbjct: 417 NLLQQQHDQWEEEGKALRQRLQKLTGERDTLA---------GQTVDLQGEVDSLSKEREL 467
Query: 1518 LRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKM 1577
L+ E+L+Q+ +L E L + L+ + G +EE ++ +E +Q+M
Sbjct: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 1578 VENLK----KQISEL----------KIKNQQLDLENTELSQKNSQNQEKLQEL----NQR 1619
+ L+ + +SEL ++ + L E TE++ ++ ++ + EL N
Sbjct: 528 LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
Query: 1620 LTEMLCQKEKEPGNSALEER-EQEKFNLKEELERCKVQSSTLVSSLEA----------EL 1668
TE+ + SAL E +K L ++L + + ++ ++ S +EA +L
Sbjct: 588 KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647
Query: 1669 SEVKIQTHIVQQENHLLKDELEKMKQ--LHRCPDLSDFQQKISSVLSYNEKLLKEKEALS 1726
+E + + + ++N L+ +L+K ++ DL D Q++ + +K L E
Sbjct: 648 AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----QKKLSESRHQQ 703
Query: 1727 EELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN 1785
E + +++L ++ E +A QE+++ + A+L+ +L A + Q+L + +Q ++
Sbjct: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763
Query: 1786 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG---------KSWAPEIATHPSGLH 1836
++S L QQ+ ++ L Q+Q + E+ T S
Sbjct: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
Query: 1837 NQQ----KRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1892
++ ++L+ + + EQQ E E Q + K H +E + LES L
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES--LE 881
Query: 1893 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1952
+ + L TE E + +RE +E++ A + QM LE E E + L E L
Sbjct: 882 REKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALCQM-QLETEKERVSL-LETL 934
Query: 1953 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2012
+ Q +L + +++ LR +Q L++Q + + Q + QR+L +A R
Sbjct: 935 LQTQKELADASQQLERLRQD---------MKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 2013 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2069
++ L+ +S + + ++ V ++ +++ + +LV++ +QEK+ + +E
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
Score = 40.0 bits (92), Expect = 0.024
Identities = 105/550 (19%), Positives = 212/550 (38%), Gaps = 77/550 (14%)
Query: 1556 SQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQE 1615
+Q W+K + ++ +V L+ ++ + + Q+L+ Q E ++E
Sbjct: 34 NQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEE 93
Query: 1616 LNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEA--------- 1666
N L E+L + E+E E + L+ +E+ V + L +E
Sbjct: 94 PN--LDELLVRLEEE--QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR 149
Query: 1667 -ELSEVKIQTHIVQQ-ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1724
EL + Q + Q+ LK E ++ L R ++ F++ + S ++ L E +A
Sbjct: 150 DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWR--EVVTFRRHFLEMKSATDRDLMELKA 207
Query: 1725 ----LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDT 1780
LS L +C +L + +E +QL+ K Q LE
Sbjct: 208 EHVRLSGSLLTCCLRLT--------VGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKE 259
Query: 1781 VQNVNLQMSRMKS--DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA------------- 1825
+ ++ ++KS DL + + + + Q QN +
Sbjct: 260 AHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETN 319
Query: 1826 -PEIATHPSGL--HNQQKRLSWDKLDHLMNEEQQLLWQENERL-QTMVQNTKAELTHS-- 1879
E+ H + L + Q+++LS L ++ + Q++ +E + + Q EL S
Sbjct: 320 HTELMEHEASLSRNAQEEKLS---LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376
Query: 1880 -------REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLS-LKRECDQFQKEQSPANRK 1931
+K L ++L + ++ + QE ++ L+++ DQ+++E
Sbjct: 377 SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEG------ 430
Query: 1932 VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQA 1991
+L Q L+ + E + L + V L ++ + R + L++L+Q+A
Sbjct: 431 ----KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEA 486
Query: 1992 CPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQ 2051
+ LQLQ Q ++ Q QEEL E Q +++ +E + E
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQ--QEELHLAVRERERLQ----EMLMGLEAKQSESLS 540
Query: 2052 KLKLVKRLLQ 2061
+L ++ L+
Sbjct: 541 ELITLREALE 550
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 208 bits (530), Expect = 4e-53
Identities = 383/1789 (21%), Positives = 736/1789 (41%), Gaps = 204/1789 (11%)
Query: 347 ELTLALENELLVTKNSIHQAALASFKAEIRHLL-----------ERVDQVVREKEKLRSD 395
E L E E L + Q L + ++R L E+ Q +R +++LR
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309
Query: 396 LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
++ + + E + E R E LR+ EE +E+ +LR+E+E+ ++
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQ------QLRREQEEERREQQ 363
Query: 456 KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
+R + E+ E+ E +R L ++ R E + L ++L + L + Q E
Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQQLRREQQLRRE 422
Query: 516 NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE----LQSELEEYRAQG 571
L + QEE + ++E ER+ + L+ + +E L+ E E R +
Sbjct: 423 QQLRRE-------------QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469
Query: 572 RVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ-MKEQHHRDICC 630
+ LK EE +E E +E + E E EQ +K Q +
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 631 LRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAA 690
RL E ++R +++ +E + +R E + E++ LK E
Sbjct: 530 QRLRSEQQLRREQEE----------RREQLLKREEEKRLEQERREQRLKRE--------- 570
Query: 691 VLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL------RLQHEMELKARLTQAQASF 744
+E + + EEE++Q ++K E+E+ L+++L RL+ E + RL + +
Sbjct: 571 --QEERRDQLLKREEERRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPEE 627
Query: 745 EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQREL-Q 803
ER ++ L+S E + + L +E ++ +++L E+ LE+ R+ E+ ++EL +
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 804 EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ 863
E +E+ R + + Q +S+ + S + EG+ R++ ++ + ++RE + Q
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 864 WEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ 923
W+ E+ Q+ E Q +R+ T Q E E+ ++ L++ R+Q +
Sbjct: 748 WQEEERAHRQQQEEEQ-------RRDFTWQ---WQAEEKSERG-RQRLSARPPLREQRER 796
Query: 924 DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL-ASQRLERLEMEH 982
L Q+ L + E K +R+ RERE+ L EQL +R ++L+ E
Sbjct: 797 QLRAEERQQREQRFLPEE---EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853
Query: 983 D---QERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1039
D ++++ S+ + + E + R LQ ++++ QQ +LQ
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ------LLQ 907
Query: 1040 SGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQ 1099
+ + EE E +Q Q EE LQ+ EQ ++E R ++
Sbjct: 908 EEEEELQREERE---KRRRQEQERQYREEE-----QLQQEEEQLLRE--------EREKR 951
Query: 1100 RLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVR 1159
R Q+ E L + + G E+ ++ + ++ E + + E+ E R
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 1160 DLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
++ E++ EE + E + E R + + ++ Q +EQL+ +
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEEEQLLGEERE 1069
Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM---- 1275
R E ++ + + +++ ++L PE + + E RE + LQ+E +
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE--RERQCREEEELQQEEEQLLREE 1127
Query: 1276 -ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
E R + LE EV + +++L + E LE+ Y E + +E L+
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 1335 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEEC 1393
Q K + +E + + + + E + L+ + +E R V+ E
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 1394 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQ---------NQVILEENT 1441
+Q Q LE ++QL ++ ++ L G Q QER R Q Q+ EE
Sbjct: 1248 EQFRQ-LE-DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305
Query: 1442 TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1501
K + + + E EK + QE RK +E +L ++ +E+ L+
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER--------EEQPLRRQE 1357
Query: 1502 HDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--LNEEDSISNLKLGTLNGSQEE 1559
D + E++ + + ++ L++E + R E L EE +L Q+
Sbjct: 1358 RDRKFREEELRHQEQGRKF----LEEEQRLRRQERERKFLKEEQ-----QLRCQEREQQL 1408
Query: 1560 MWQKTETVKQENAAVQKMVENLKKQISELKIKNQQ-----LDLENTELSQKNSQNQEKLQ 1614
+ ++E + + + K + E +++ Q+ L+ E +++ + +E+ Q
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 1615 ELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQ 1674
L +R + L ++E++ LEE +Q + ++E +R + E + E + Q
Sbjct: 1469 LLQEREEQQLHRQERD--RKFLEEEQQLR---RQERDRKFREQELRSQEPERKFLEEEQQ 1523
Query: 1675 THIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD 1734
H Q++ L++E + +Q D +K E+L +E+E E+ S +
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE----EEQLRQERE---EQQLSRQE 1576
Query: 1735 KLAKSSLLEHRIATMKQEQKSW--EHQSASLKSQLVASQEKVQNLEDTVQ----NVNLQM 1788
+ K L E ++ +QE+K E Q + Q QE+ + + Q Q+
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 1789 SRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1848
R + D + ++E + +QE +QL++ + + E G Q +R D+
Sbjct: 1637 HRQERDRKFLEEEPQLRRQE---REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-- 1691
Query: 1849 HLMNEEQQLLWQENER--LQTMVQNTKAELT---HSREKVRQ-LESNLLPKHQKHLNPSG 1902
EEQQL QE ER LQ Q + EL E++RQ E L + +++
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY----- 1746
Query: 1903 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1962
E+E+L +RE Q ++++ +RK + L QE E L ++ +K + ++
Sbjct: 1747 -RKILEEEQLRPEREEQQLRRQE--RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803
Query: 1963 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELE 2022
E + + + W+ + LQ L+ Q Q L+ ER Q+ E E
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQ------------LEEQEQRLRQERDRQYRAE--E 1849
Query: 2023 NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
++ + + QE ++R E E+KL+ Q+K Q QV
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898
Score = 203 bits (517), Expect = 1e-51
Identities = 394/1846 (21%), Positives = 762/1846 (41%), Gaps = 241/1846 (13%)
Query: 331 ILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKE 390
IL+ LD +G ++ E L I + A A + A + Q E
Sbjct: 57 ILELLDLDSNGRVDFNEFLLF-----------IFKVAQACYYA--------LGQATGLDE 97
Query: 391 KLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI 450
+ R+ D E L E D +RR E R+L+EE +R + E +E +
Sbjct: 98 EKRARCDGKESLLQDRRQEED------QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151
Query: 451 LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN-----AEKLAEYEN 505
+Q+ KQ LEQ ++ + +E R R +E R E E L++ E+ + E
Sbjct: 152 EEQSEKQE-RLEQR-DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 506 LTNKLQRNLENVLAEKFGDLDPSSAEFFLQEE-------RLTQMRNEYERQCRVLQDQVD 558
L + L E+ + QEE R T +R E E+ LQ++
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK----LQEEEP 265
Query: 559 ELQSELEEYRAQGRVL-RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVI 617
+ Q EL+E Q R L R L+ EE + + +E E
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 618 EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD 677
E+ ++Q R LR E E++ E+QL ++ Q+ +++ E ++
Sbjct: 326 ERREQQEERREQQLRREQEER---REQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 678 LKNEIAELQGQAAVLKE--AHHEATCRHEEE-KKQLQVKLEEEKTHLQEKLRLQHEMELK 734
L+ E +L+ + + +E E R E++ +++ Q++ E++ QE+ R + + E +
Sbjct: 383 LRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 735 ARLTQAQASFEREREGLQSSAWT-----EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEE 789
R + + E R+ L+ T E + + L ++ E+ +E+ L E+ E++E
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 790 LRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE 849
R++ L + Q E +E R K + E R ++ + +S+ Q E+ E Q L+ R+E
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEER----LQQRLRSEQQLRREQEERREQLLK---REE 554
Query: 850 LKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKE 909
K L++++RE++ + E +++ Q +E ++ LKRE+ L +RE +E+ +E
Sbjct: 555 EKRLEQERREQRLKRE-QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 910 HLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQ 969
++R++ ++ SE Q+ Q+ +RE +ER E + E+
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQL-------RREQQERREQRLKREEEEE 666
Query: 970 LASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1029
QRL+R EH++ER+E E + + + ++ +E QSK+
Sbjct: 667 RLEQRLKR---EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723
Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK 1089
+ Q G + E+E + S LQ E+ +RAH Q +E +
Sbjct: 724 RK-------QEGQRRRQEQEEKRRRRESELQWQEE------------ERAHRQQQEEEQR 764
Query: 1090 -------MATEIS-RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEP-FLQQNRTKQ 1140
A E S R +QRL P ++ + +Q E FL + K+
Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPP------LREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 1141 VEGVTRRH---VLSDLEDDEVRDLGSTGTSSVQRQE--VKIEESEASVEGFSELENSEET 1195
RR L LE++E +QR+E +++E E ++ E S+E
Sbjct: 819 QRRRQRREREKELQFLEEEE----------QLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Query: 1196 RTES---WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASP 1252
R + W+L+ + + + L A ++ +++Q L + L+++ + R E
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Query: 1253 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1312
+Y+ + E L+EE E R + E ++ + +++L E
Sbjct: 929 QYREEEQLQQEEEQLLREE---REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Query: 1313 LEKSY-DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL-EIEPDGNIL 1370
EK Y +E +++ EE +LR + + + QE WE E++ + L
Sbjct: 986 REKKYREEEELQQEEEQ--LLREEREKRRRQE----------WERQYRKKDELQQEEEQL 1033
Query: 1371 QLNQTLEECVPRVRSVHHVIEECKQENQYLEG------NTQLLEKVKAHEIAWLHGTIQT 1424
+ + + + EE +QE + L G Q LE+ E Q
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 1425 HQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ 1484
+E P + + +E +++ Q + + E EK + QEL R+ +E + ++
Sbjct: 1094 LREEPEKRRR---QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 1485 KDVLSHGEKEEELKAMMHDLQITCSE----MQQKVELLRYESEKLQQENSILRNEITTL- 1539
+ +L +EE K +L+ E Q++ +LLR E EK +QE E L
Sbjct: 1151 EQLL----REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206
Query: 1540 --------NEEDSISNLKLG--------------TLNGSQEEMWQKTETVKQENAAVQKM 1577
+ED S+LK G + E +++ E + + Q+
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD 1266
Query: 1578 VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE 1637
+++L + E + ++++ + + ++ +E+L+ Q+ + +K +E E
Sbjct: 1267 LQHL---LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323
Query: 1638 EREQE--------KFNLKEELERCKVQSSTLVSSLEAELSEVKIQ-----THIVQQENHL 1684
ERE++ KF +E+L + + + + + E +++ +++E L
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383
Query: 1685 LKDELE----KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
+ E E K +Q RC + +Q++ + K +E++ LS + ++ K
Sbjct: 1384 RRQERERKFLKEEQQLRC---QEREQQLRQ--DRDRKFREEEQQLSRQ-----ERDRKFR 1433
Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800
E ++ ++E+K E + + + +E+ Q L++ + Q+ R + D + ++
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ---QLHRQERDRKFLEE 1490
Query: 1801 EKEALKQEVMSLHKQLQNAGGKSWAPE--IATHPSGLHNQQKRLSWDKLDHLMNEEQQLL 1858
E++ +QE ++ + +S PE LH QQ++ + + EEQQL
Sbjct: 1491 EQQLRRQE---RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF------LQEEQQLR 1541
Query: 1859 WQENERLQTMVQNTK-AELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEK------ 1911
QE + + ++ K E R++ + + + + +K + EQE+
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 1912 LSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
L+R+ Q Q Q +RK + L QE E L + +K ++ + QL + +
Sbjct: 1602 QQLRRQEGQQQLRQE-RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQ----FLQLQRQLLQAERINQHLQEELENRTSE 2027
+ QLLQ+ + R++ F + ++QL + ER + LQEE + R E
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720
Query: 2028 TNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+EQL E+ + +++ + K L +E++ +E+ L
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYR--KILEEEQLRPEREEQQL 1764
Score = 112 bits (279), Expect = 5e-24
Identities = 152/666 (22%), Positives = 284/666 (42%), Gaps = 66/666 (9%)
Query: 376 RHLLERVDQVVREKEKLRSDLD-KAEKLKSLMASEVDDHHAAIERRNEYNLRK-LDEEYK 433
RH E +Q+ RE++K D K+++ K L+ E ++ E ++ + L +E +
Sbjct: 1291 RHFPEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 434 ERIAALKNELRKEREQIL--QQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN 491
E+ + RK RE+ L Q+ G++ LE EQ + + + E ++++ L +E E
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER---EQ 1406
Query: 492 ELLENAE-KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 550
+L ++ + K E E ++ +R+ + E+ +F +E++L Q R+ R+
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 551 RVLQDQVDELQSELEE----YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 606
L + +E Q +E + + + LR ++ E E S EPE EE
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ--EPERKFLEEE--- 1521
Query: 607 LNMSIEAELVIEQM-KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
+Q+ ++Q R L+ E ++R E+ +K +E + R E
Sbjct: 1522 -----------QQLHRQQRQRKF----LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Query: 666 NETHTLEKQISDLKNEIAE--LQGQAAVLKEAHHEATCRHEEEKKQLQV----KLEEEKT 719
E L +Q D K + E ++ Q K E R +E ++QL+ K E++
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626
Query: 720 HLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTS 778
LQE+ Q H E + + + R+ Q + K R Q L++ ++QL
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686
Query: 779 LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 838
+EE + E+ ++ LQE ++ E R+ + E Q Q+ R E
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746
Query: 839 LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 898
+ LE + ++ Q+ +R+E+ + E+++L QE E Q+L + R+ L Q
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE-REEQQLRSQESDRKFREEEQLRQ 1805
Query: 899 EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRERE 958
ER E QQL D + E +Q L +Q L+ R+ R E
Sbjct: 1806 ER----------------EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849
Query: 959 EVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEI 1018
+ A+++ + + + L E +Q+R++ + L E+I + + + +R EI
Sbjct: 1850 QF-----ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR---QQKEEQRHRQVGEI 1901
Query: 1019 SRLQSK 1024
+ K
Sbjct: 1902 KSQEGK 1907
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 206 bits (524), Expect = 2e-52
Identities = 371/1710 (21%), Positives = 712/1710 (41%), Gaps = 261/1710 (15%)
Query: 393 RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 445
+ DL K K + ++ + +E+ E + + E + I AL L +
Sbjct: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
Query: 446 EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 501
E EQ K+ ++++QE+E + T+ L S +KE L+NEL+ K +
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 502 EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 558
E + NL +L+ N + L+E+ + S +E + ++R +E Q LQ Q+D
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 559 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 618
E +E Q L+N +EANS + S++ EL+
Sbjct: 207 ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242
Query: 619 QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 671
Q+K H ++ L ++E + +E ++ + V C+ +++N+++++E E L
Sbjct: 243 QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302
Query: 672 EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 729
K S+ N+I + Q E +H E+ + +LE + + L++++ +
Sbjct: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359
Query: 730 EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 787
++LK + + F ERE L E K+ L +E+ ++EK E
Sbjct: 360 NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408
Query: 788 EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 844
L K+ +E+H RE+Q +E+ + E S++ F SD +K +Q L
Sbjct: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462
Query: 845 RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 898
+++ ++LQ++++E +E ++ E+ Q E E+ + E++K+++ + + Q
Sbjct: 463 --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
Query: 899 EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 956
++ L + E+ LL+ + L+ +E LLS Q L EL+++ K L+E
Sbjct: 521 QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1012
+ V + + + LE +E+ + ++KL M+N HK CE +R
Sbjct: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625
Query: 1013 EMSTEISR------------------LQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGD 1053
E+ ++ + L+ +KE Q L L +V+ E+ EV
Sbjct: 626 ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685
Query: 1054 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL--EPGLVMS 1111
SL ++ +L E + L+ Q KE+V + I++L+++LQ + E +
Sbjct: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQ--KEDVILKEHITQLEKKLQLMVEEQDNLNK 743
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
+E + F T Q FL++ ++ E E D V L + G S +
Sbjct: 744 LLENEQVQKLFVKT--QLYGFLKEMGSEVSE--------DSEEKDVVNVLQAVGESLAKI 793
Query: 1172 QEVKIEESEASVEGFSELEN-----SEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1226
E K + E ELE EE+ + ELK+ + +++ ++L + + +
Sbjct: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853
Query: 1227 KQDLLFDVSVLKKK-----------LKMLERIPEASPKYKLLYEDVS---RENDCLQEEL 1272
K+ L D+ +K L +E + + K ++ E +E++ L+ L
Sbjct: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 1273 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIEN-------- 1324
E R + AE+ L+D L K V LS K +E KIEN
Sbjct: 914 EQKELR---------DRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEKECKEK 963
Query: 1325 -EELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRV 1383
E++N + L ++L S R + + LE+L E D QL+ ++ + +
Sbjct: 964 EEKINKIKLVAVKAKKELDSS---RKETQTVKEELESLRSEKD----QLSASMRDLIQGA 1016
Query: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI------- 1436
S +++ E +++++ L+ +EK +A+ + +Q + I
Sbjct: 1017 ESYKNLLLEYEKQSEQLD-----VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
Query: 1437 ------LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSH 1490
L+ N LL Q Q + + ELE KLQ+ +K+KE T + + +++
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQKIKEHATTVNELEELQVQ 1130
Query: 1491 GEKE-EELKAMMHDLQITCSEMQQ----KVELLRYE--SEKLQQENSILRNEITTLNEED 1543
+KE ++L+ M +L++ + QQ +E+ YE ++L Q+ + N+I L +E
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190
Query: 1544 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1603
I K TL + + +++N +++++ KK++++ K + L
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK 1250
Query: 1604 QKNSQNQEKLQELNQRLTEMLCQKEK---------EPGNSALEEREQEKFNLKEELERCK 1654
+ +Q++++ +L E+ +K K E L +Q L+EE K
Sbjct: 1251 GELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAK 1310
Query: 1655 VQSSTLVSSLEAELSEVKIQTHIVQQENHLL--------KDELEKMKQL--HRCPDLSDF 1704
+ +T+ S E E +V++ + QQ+N + K E E ++ L L D
Sbjct: 1311 AEQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS 1368
Query: 1705 QQKISSVLSYNEKLLKEKEALSEELNSCV-DKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
Q + +S + L E + L E N + + ++K + L ++ +++ E + +
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQT 1428
Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
SQL + E ++N + Q+ ++ + R T E L+Q++ + QL +
Sbjct: 1429 VSQLTSQNEVLRN------SFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEP 1479
Query: 1824 WAPEIATHPSGLHNQQKRLSWD--KLD-HLMNEEQQLLWQENERLQTMVQNTKAELTHSR 1880
+ L N ++R + D LD H + E E E ++T T E S
Sbjct: 1480 TTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE------EGEGMET----TDTESVSSA 1529
Query: 1881 EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQ 1940
Q LL + L P +E+L K S + +N L +
Sbjct: 1530 STYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK---------LSSTTKSADHLNGLLR 1580
Query: 1941 ELE---TIHLENEGLKKKQVKLDEQLMEMQ 1967
E E I +E L K +++ E+ E +
Sbjct: 1581 ETEATNAILMEQIKLLKSEIRRLERNQERE 1610
Score = 144 bits (363), Expect = 9e-34
Identities = 279/1388 (20%), Positives = 589/1388 (42%), Gaps = 238/1388 (17%)
Query: 766 QELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR----------------EKM 809
++L +F ++Q+ L++K EL KE+ E + + EG EK
Sbjct: 28 EDLIKFAKKQMM-LIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
Query: 810 ETE-----CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQW 864
ETE + +++ + + K+ + L+ Y +E+++L+ + +S++
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGD-AHKELEQSHINYVKEIENLKNELMAVRSKY 145
Query: 865 EFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKT----------YKEHL 911
+K L ++ EA L E LK + + + + +E +EK ++ L
Sbjct: 146 SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQL 205
Query: 912 NSMVVERQQLLQDLEDL--RNVSETQQSL--LSDQILELKSSHKRELREREEVLCQAGAS 967
++ E+++ + L+++ N Q+++ L +++L+LK+ H+ E++E ++CQ AS
Sbjct: 206 DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKE---LMCQIEAS 262
Query: 968 EQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE 1027
+ EH+ E ++KL ++ CE +++ + + + +++
Sbjct: 263 AK-----------EHEAE----INKLNELKENLVKQCEASEKNIQK------KYECELEN 301
Query: 1028 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1087
+++ATS + C ++ +E + ++ + ++ D L L+ H E
Sbjct: 302 LRKATSNANQDNQICSILLQENTFVEQVVN------EKVKHLEDTLKELESQHSILKDEV 355
Query: 1088 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1147
M +L+ Q ++ EFF + + K+ +G
Sbjct: 356 TYMNNLKLKLEMDAQHIKD-------------EFFHEREDLEFKINELLLAKEEQGCVIE 402
Query: 1148 HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQIS 1207
+ S+L + + + + Q +K E+ + + +E S+ + E L +I
Sbjct: 403 KLKSELAGLNKQFCYTVEQHNREVQSLK-EQHQKEISELNETFLSDSEK-EKLTLMFEIQ 460
Query: 1208 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-RIPEASPKYKLLYEDVSREND 1266
L+EQ C+ ++KQ+ + + L++ +++L+ + E++ K +E + ++
Sbjct: 461 GLKEQ-------CENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 1267 C----LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKI 1322
LQ++LR T D LE L E +L + + + E+ T +L++ +
Sbjct: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573
Query: 1323 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPR 1382
+ + ++ L+GKI L E E D I +L + EE
Sbjct: 574 SLSQRDTMLKELEGKINSLTE--------------------EKDDFINKLKNSHEE---- 609
Query: 1383 VRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI--LEEN 1440
+ + ++C++E + + +L +KV+ TIQ + E + N++ LEE
Sbjct: 610 ---MDNFHKKCEREERLI---LELGKKVEQ--------TIQYNSELEQKVNELTGGLEE- 654
Query: 1441 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500
T+ E + KL++L ++K +L + K+VLS E+K++
Sbjct: 655 ---------------TLKEKDQNDQKLEKLMVQMK----VLSEDKEVLS-----AEVKSL 690
Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE-----DSISNLKLGTLNG 1555
+ SE +Q L E Q+E+ IL+ IT L ++ + NL N
Sbjct: 691 YEENNKLSSEKKQLSRDL--EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENE 748
Query: 1556 SQEEMWQKTET---VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1612
++++ KT+ +K+ + V + E K ++ L+ + L N E Q EK
Sbjct: 749 QVQKLFVKTQLYGFLKEMGSEVSEDSEE-KDVVNVLQAVGESLAKINEEKCNLAFQRDEK 807
Query: 1613 LQELNQRLTEMLCQKEK-----EPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAE 1667
+ EL + E+ C +E+ E S L + EQEK L++ELE ++QS +L+++
Sbjct: 808 VLELEK---EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EIQSEK--EALQSD 860
Query: 1668 LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSE 1727
L E+K + EN L ++E++ Q ++ + ++K N K L E++ L +
Sbjct: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD 920
Query: 1728 ---ELNSCVDKLAKS-SLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQN 1783
EL D LAKS S+ ++++K+ ++ E+ L+ + +EK+ ++
Sbjct: 921 RRAELILLKDSLAKSPSVKNDPLSSVKELEEKIEN----LEKECKEKEEKINKIKLVAVK 976
Query: 1784 VNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA--GGKSWAPEIATHPSGLHNQQKR 1841
++ + + + ++E E+L+ E L +++ G +S+ + + ++Q
Sbjct: 977 AKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK--QSEQLD 1034
Query: 1842 LSWDKLDHLMNEEQQLLWQ-ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1900
+ ++ ++ + + L Q N LQ N+ E +R + Q + LL +
Sbjct: 1035 VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR 1094
Query: 1901 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1960
+ M E E ++ QKEQ K+ + + ELE + ++ L+K++ +L
Sbjct: 1095 AKAMVDKELE-------AEKLQKEQ-----KIKEHATTVNELEELQVQ---LQKEKKQLQ 1139
Query: 1961 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE 2020
+ + E++ ++ A QQ + + +L ++L Q + E+
Sbjct: 1140 KTMQELELVKKDA--------------QQTTLMNMEIADYERLMKELNQKLTNKNNKIED 1185
Query: 2021 LENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL-----------QEKVNQLKE 2069
LE Q ++ +T ++ + + E+K +K+LL Q + + L
Sbjct: 1186 LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLIL 1245
Query: 2070 QVSLPGHL 2077
Q SL G L
Sbjct: 1246 QASLKGEL 1253
Score = 122 bits (307), Expect = 3e-27
Identities = 260/1339 (19%), Positives = 537/1339 (40%), Gaps = 180/1339 (13%)
Query: 354 NELLVTKNSIHQAALASFKAEIRHLLER----VDQVVREKEKLRSD------------LD 397
NELL+ K + K+E+ L ++ V+Q RE + L+ L
Sbjct: 388 NELLLAKEE-QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLS 446
Query: 398 KAEKLKSLMASEVDDHHAAIERR---------NEYNLRKLDEEYKERIAALKNELRKERE 448
+EK K + E+ E N +LR++ E + + ++ +E E
Sbjct: 447 DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE 506
Query: 449 QILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 508
+ QQ EL+Q++ A TE++ + + + EN + LL E + E EN
Sbjct: 507 SMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK----LLSQQELVPELENTIK 562
Query: 509 KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR 568
LQ V D E + LT+ ++++ + + +++D + E
Sbjct: 563 NLQEK-NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621
Query: 569 AQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI 628
L L L + ++ NS E E ++ N L +E E +KE+ D
Sbjct: 622 R----LILELGKKVEQTIQYNS---ELE-----QKVNELTGGLE-----ETLKEKDQNDQ 664
Query: 629 CCLRLELEDKVRHYEKQLDETVVSC------KKAQENMKQRHENETHTLEKQISDLKNEI 682
+L ++ KV +K++ V K + E + + E +K+ LK I
Sbjct: 665 KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHI 724
Query: 683 AELQGQAAVLKEAHHEATCRHEEE-------KKQLQVKLEEEKTHLQEKLRLQHEMELKA 735
+L+ + ++ E E E K QL L+E + + E + + +
Sbjct: 725 TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQ 784
Query: 736 RLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTLEKEELRKEL 794
+ ++ A E+ L + +EKV L +E++ +E + E K L E K L
Sbjct: 785 AVGESLAKINEEKCNL--AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842
Query: 795 LEKHQRELQEGREKMETE------CNRRTSQIEAQFQSDCQKVTERCESALQSLEG---- 844
L K E+Q +E ++++ N +T ++V++ C + E
Sbjct: 843 LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 902
Query: 845 -RYRQELKDLQEQQ--REEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQERE 901
+ + LK L EQ+ R+ +++ KD L + + + L + E+ + + +E
Sbjct: 903 IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 962
Query: 902 MLEK---------TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
EK K+ L+S E Q + ++LE LR+ + + + D +++ S+K
Sbjct: 963 KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD-LIQGAESYKN 1021
Query: 953 ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
L E E+ SEQL ++ EH R E +++ L + CET + +
Sbjct: 1022 LLLEYEK------QSEQLDVEKERANNFEH---RIEDLTRQLRNSTLQ---CETINSDNE 1069
Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
++ I LQS K ++ L + ++ V E E E Q EQ ++E+
Sbjct: 1070 DLLARIETLQSNAKLLE--VQILEVQRAKAMVDKELEAE-------KLQKEQKIKEHATT 1120
Query: 1073 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1132
+ L+ Q KE ++ + Q L+ ++ ++ ++ ++ E +
Sbjct: 1121 VNELEELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176
Query: 1133 LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK-IEESEASVEGFSELEN 1191
N+ ++E + + + + + +++ ++ SSVQ+ E K + + V+ EL +
Sbjct: 1177 --TNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234
Query: 1192 SEETRTE----SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1247
S++ T+ LK ++ Q+Q+ + + +K K+ E +
Sbjct: 1235 SKQAETDHLILQASLKGELEASQQQVEVYKIQL-------------AEITSEKHKIHEHL 1281
Query: 1248 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT 1307
++ +++ + LQEE R + E E + R+ + LK+ + +
Sbjct: 1282 KTSAEQHQRTLSAYQQRVTALQEECRAAKA---EQATVTSEFESYKVRVHNVLKQQKNKS 1338
Query: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1367
+ + + K E E L +L+ +L+ K++ Q ++ + + L+ L+ E D
Sbjct: 1339 MS----QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ------INVSELQTLQSEHDT 1388
Query: 1368 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTIQTHQ 1426
+ + N+ L+E V + + + + EN ++ +TQ + ++ T Q
Sbjct: 1389 LLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL----------TSQNEV 1438
Query: 1427 ERPRVQNQVILEENTTLLGFQDKHFQ--HQATIAELELEKTKLQELTRKLKERVTIL--V 1482
R ++QV +H Q H+ T+ L+ + +K++ +LK T V
Sbjct: 1439 LRNSFRDQV-------------RHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
Query: 1483 KQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1542
+ L + + + D+ E + +E ++E + ++ ++ LN
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETT--DTESVSSASTYTQSLEQLLNSP 1543
Query: 1543 DSISNLKLGTLNGSQEEMWQK----TETVKQENAAVQKMVENLKKQISELK-IKNQQLDL 1597
++ L ++EE+ QK T++ N +++ + ++K +K++ L
Sbjct: 1544 ETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRL 1603
Query: 1598 ENTELSQKNSQNQEKLQEL 1616
E + +K++ N E L+ +
Sbjct: 1604 ERNQEREKSAANLEYLKNV 1622
Score = 98.2 bits (243), Expect = 7e-20
Identities = 167/758 (22%), Positives = 328/758 (43%), Gaps = 137/758 (18%)
Query: 347 ELTLALENEL-LVTKNSIHQ-----AALASFKAEIRHLLERVDQVVREKEKLRSDLDKAE 400
E L LE E+ + + S+ Q + L ++ E L + ++++ EKE L+SDL
Sbjct: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL---- 861
Query: 401 KLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 460
L+ A+E R NL EE + + K+E+ E+E+ +
Sbjct: 862 -LEMKNANEK-------TRLENQNLLIQVEEVSQTCS--KSEIHNEKEKCFIK------- 904
Query: 461 LEQEIEKAKTEENYIRDRLA-LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 519
E E K E+ +RDR A L L ++S ++ ++N + L+ + L K++ NLE
Sbjct: 905 -EHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN-DPLSSVKELEEKIE-NLEKECK 961
Query: 520 EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLK 579
EK ++ ++ L R E + ++++++ L+SE ++ A R L ++
Sbjct: 962 EKEEKINKIKLVAVKAKKELDSSRKE----TQTVKEELESLRSEKDQLSASMRDL---IQ 1014
Query: 580 NSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV 639
+ S + N+ +E E EQ+ + R E ++
Sbjct: 1015 GAESYK----------------------NLLLEYEKQSEQLDVEKER-----ANNFEHRI 1047
Query: 640 RHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNEIAELQ-GQAAVLKEA 695
+QL + + C+ E++ R E TL+ L+ +I E+Q +A V KE
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIE----TLQSNAKLLEVQILEVQRAKAMVDKEL 1103
Query: 696 HHEATCRHEE---------EKKQLQVKLEEEKTHLQEKLR----LQHEMELKARLTQAQA 742
E + ++ E ++LQV+L++EK LQ+ ++ ++ + + + A
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163
Query: 743 SFEREREGL-QSSAWTEEKVRGLTQEL------EQFHQEQLTSL---VEKHTLEKEELRK 792
+ER + L Q K+ L QE+ ++ QE++TSL V+++ EK K
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE-EKNTKIK 1222
Query: 793 ELLEKHQRELQEGRE----------KMETECNRRTSQIE------AQFQSDCQKVTERCE 836
+LL K ++EL + ++ ++ E Q+E A+ S+ K+ E +
Sbjct: 1223 QLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK 1282
Query: 837 SALQSLE---GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTS 893
++ + + Y+Q + LQE+ R K+ E+ +T E + + LK++K S
Sbjct: 1283 TSAEQHQRTLSAYQQRVTALQEECRAAKA----EQATVTSEFESYKVRVHNVLKQQKNKS 1338
Query: 894 LVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE 953
++Q K +EHL ++ + + LQD ++ ++ ++ L + L H +
Sbjct: 1339 --MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396
Query: 954 LRER-------EEVLCQAGASEQLA----SQRLERLEMEHDQERQEMMSKLLAMENIHKA 1002
L+E E LC + + +Q + +L +++ R ++ ++ H+
Sbjct: 1397 LQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456
Query: 1003 TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
T ET ++ ++M ++ +L K SP+S QS
Sbjct: 1457 TVETLQQQLSKMEAQLFQL----KNEPTTRSPVSSQQS 1490
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 204 bits (518), Expect = 1e-51
Identities = 362/1785 (20%), Positives = 741/1785 (41%), Gaps = 252/1785 (14%)
Query: 353 ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 412
E + L+T+ S + L ++ + +KEKL +++ + K ++E +
Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606
Query: 413 HHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQI---LQQAGKQRLELEQEIEK 467
H +++ E L+ + ERI + +R+E++++ L+ + E E+++++
Sbjct: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666
Query: 468 AKTEENYIRDRLALSLKENSRLENELLENAEKL-AEYENLTNKLQRNLENVLAEKFGDLD 526
A+ E +++++ K + EL E ++L AE + + +E +L+
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS--- 1723
Query: 527 PSSAEFFLQEERLTQMRNEYE---RQCRVLQDQVDELQSELEEYRAQ-----GRVLRLPL 578
+E L +++ EYE ++ + L + D L E+++ + Q + L
Sbjct: 1724 --------MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA 1775
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
+ G + G +EE + L+MS + D+
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPG-ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE 698
+ +Y +Q+D+ +E KQ+++ + TLE + + L ++I+ G+ +L+E E
Sbjct: 1835 INNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE---E 1890
Query: 699 ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTE 758
T K+ +QE+L +R+T+ + + E E++ L+ +
Sbjct: 1891 VT------------KMNLLNQQIQEEL---------SRVTKLKETAEEEKDDLEERLMNQ 1929
Query: 759 EKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 818
+ L + + Q+ + ++ LE E + L+K EL+E ++++ E + S
Sbjct: 1930 --LAELNGSIGNYCQDVTDAQIKNELLESE---MKNLKKCVSELEEEKQQLVKEKTKVES 1984
Query: 819 QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEA 878
+I ++ Q + E + K+LQE +E++ E +L ++C
Sbjct: 1985 EIRKEYLEKIQGAQK---------EPGNKSHAKELQELLKEKQQ----EVKQLQKDCIRY 2031
Query: 879 QELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSL 938
QE + + K V T+ ++ LE T KE+L V R++ +L + + + QS
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEIT-KENLAQAVEHRKKAQAELASFKVLLDDTQSE 2090
Query: 939 LSDQILELKSSHKRELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAM- 996
+ ++L K+EL+ +E V Q ++ +RLE+ E +H +E++ M KL A+
Sbjct: 2091 AA-RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR 2149
Query: 997 -ENIH--------KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1047
E +H + T D+E ++ L S + ++ T +S LQ + +
Sbjct: 2150 REKVHLEETIGEIQVTLNKKDKEVQQLQ---ENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206
Query: 1048 E----EVEGDGALSLLQQGEQLLEENGDVL---LSLQRAHEQAVKENVKMATEISRLQQR 1100
E E + A+ ++ +L E+N VL L H + +K N+ ++ +
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWES 2266
Query: 1101 LQKLEPGLVMSSC--LDEPATEFFGNTAEQTEPF-LQQNRTKQVEGVTR--RHVLSDLED 1155
+ E L C L E E + QN ++E + + L+DL +
Sbjct: 2267 KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSN 2326
Query: 1156 --DEVRDLGSTGTSSVQRQEVKIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQ 1212
++ ++ +++QE I+ S+ S E ++L+ S E + L +I+ +++
Sbjct: 2327 SLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR---LHEEINMKEQK 2383
Query: 1213 LMMLCADCDRASEKKQDLLFDVSVLK----KKLKMLERIPEASPKYKLLYEDVSREN-DC 1267
++ L S K++ + ++ L+ K++K LE + + ++ E+ +++ D
Sbjct: 2384 IISLL------SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437
Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1327
+ + ++T E ++ +L + V + + + + LE+ + + +E ++L
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497
Query: 1328 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
+ + KL+E + + + + + EN ++ D ++Q + L + + S
Sbjct: 2498 ---IQEAAAENNKLKEEI-RGLRSHMDDLNSENAKL--DAELIQYREDLNQVITIKDSQQ 2551
Query: 1388 HVIEECK-QENQYLEGN-TQLLEKVKAHEIAW--LHGTIQTHQERPRVQNQVI--LEENT 1441
+ E + Q+N+ LE +L EK+K E A L + QE + ++ I L+ +
Sbjct: 2552 KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611
Query: 1442 TLLGFQDKHFQHQATI----AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL 1497
+ L Q Q + T+ A+L++++ ++ L+ QK + E EEEL
Sbjct: 2612 SQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS------SQKRI---AELEEEL 2662
Query: 1498 KAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQ 1557
+ + E++ K L+ E + L + I+RNE T E ++ L
Sbjct: 2663 VCVQKEAAKKVGEIEDK---LKKELKHLHHDAGIMRNETETAEE-------RVAELARDL 2712
Query: 1558 EEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELN 1617
EM QK V +EN + +++ + +S L+ D N EL + + L+EL
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ---NSRDHANEELDELKRKYDASLKELA 2769
Query: 1618 QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHI 1677
Q + L +E++ AL N EE +SL +H+
Sbjct: 2770 QLKEQGLLNRERD----ALLSETAFSMNSTEE------------NSL----------SHL 2803
Query: 1678 VQQENHLL-KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKL 1736
+ LL KDE + LH L D ++ S L E++ L EL +K
Sbjct: 2804 EKLNQQLLSKDE----QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL----EKF 2855
Query: 1737 AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR 1796
KS + R A +Q S +VQ+L+ + ++ R+ +L+
Sbjct: 2856 RKSEEGKQRSA-----------------AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELK 2898
Query: 1797 VTQQEKEALKQEVMSLH---KQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNE 1853
QQ+ + QE+ LH QLQ K+ A +I +Q+ LSW H +
Sbjct: 2899 NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE----ELRQENLSWQHELHQLRM 2954
Query: 1854 EQQLLWQENERLQ-----TMVQNTKAELTHSREKVRQLESN------LLPKHQKHLNPSG 1902
E+ W+ +ER + + +L+H + +R+L S+ L ++Q+ +P
Sbjct: 2955 EKS-SWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPET 3013
Query: 1903 TMNPTEQEKL-----SLKRECDQFQKEQSPANRKVSQMNS----LEQELETIHLE----N 1949
+ +P + L L+ + + KE ++ Q+NS L +E T+ ++ +
Sbjct: 3014 SASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTS 3073
Query: 1950 EGLKKKQ----------VKLDEQLMEMQ--HLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
+ L++ Q L++Q+ E+Q L P + P+
Sbjct: 3074 QSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQ 3133
Query: 1998 EQFLQLQRQLL----QAERINQHLQEELENRTSETNTPQGNQEQL 2038
+ F + Q+QL + + + L+EE + R + N +EQ+
Sbjct: 3134 QSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
Score = 197 bits (501), Expect = 9e-50
Identities = 385/1784 (21%), Positives = 741/1784 (41%), Gaps = 291/1784 (16%)
Query: 379 LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAA 438
L++ D+ ++E+ K + K +KLK +++ + IE L E +
Sbjct: 75 LQQKDEALQEERKAADN--KIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132
Query: 439 LKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAE 498
K++ E++ + K +L+ ++E+ T + + A ++S E + +
Sbjct: 133 SKHDKSSTEEEMEIEKIKHKLQEKEEL--ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190
Query: 499 KLAEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQ----EERLTQMRNEYERQCRV 552
+L E E + LQ L AE+ + A F Q E+ L Q+ + + +
Sbjct: 191 QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE- 249
Query: 553 LQDQVDELQSELEEYRAQ--GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMS 610
+Q ++ LQ +LEE+ GR + L E + + + E N L +
Sbjct: 250 MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309
Query: 611 IEAE-----LVIEQMK-EQHHRDICC--LRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 662
+E E +++E+M+ E R + L+ E+ + +E Q + + ++Q
Sbjct: 310 VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQ 368
Query: 663 RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+H+ E I L+ ELQ LK+ + + E+ Q +++ + LQ
Sbjct: 369 KHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQ 428
Query: 723 EKLR----LQHEMELKARLTQAQASF-EREREGLQSSAWTEEKVRGLTQELEQFHQEQLT 777
+K + + + L+ T +Q SF + EG Q A TEE + L + + + E+
Sbjct: 429 QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ--AVTEENIASLQKRVVELENEKGA 486
Query: 778 SLVEKHTLEKEELRKE---------LLEKHQRELQEGREKMETE----CNRRTSQIEAQF 824
L+ ++E EEL+ E LLE R + RE E N+R+S E
Sbjct: 487 LLLS--SIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE--- 541
Query: 825 QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE---L 881
E + L++ + +EL L + +E + + F K +L + AE + L
Sbjct: 542 --------ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593
Query: 882 LKETLKREKTTSLVLTQEREMLEKTYK-------EHLNSMVVERQQLLQDLEDLRNVSET 934
++ +K+ + + + + LE T + E + VE++Q + + S T
Sbjct: 594 DQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQ-----SRT 648
Query: 935 QQSL-LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL 993
+ + L+D +ELKS+ + + ++ L Q LERL+ S++
Sbjct: 649 SEEISLNDAGVELKSTKQ----DGDKSLSAVPDIGQCHQDELERLK-----------SQI 693
Query: 994 LAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEG 1052
L +E N HKA E ++ E + EIS L I+E ++ S S + EE +
Sbjct: 694 LELELNFHKAQ-EIYEKNLDEKAKEISNLNQLIEEFKKNADNNS---SAFTALSEERDQL 749
Query: 1053 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGL---- 1108
+ L +L + + ++L A Q + + L +++ L
Sbjct: 750 LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809
Query: 1109 ----VMSSCLDEPATEFFGNTA--EQTEPFLQQNRTKQVEGVTR-RHVLS---------- 1151
V+ + LD+ +F + + LQ ++ +EG R RH+ S
Sbjct: 810 VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869
Query: 1152 --DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE--GFSELENSEETRTESWELKNQIS 1207
+LE ++ L V+ + IEE + V FS E + E + L +I
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Query: 1208 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1267
L+EQL +L RA E K++ + + + + LK + E SP ++ E++ E D
Sbjct: 930 TLKEQLNLL----SRAEEAKKEQVEEDNEVSSGLK--QNYDEMSPAGQISKEELQHEFDL 983
Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1327
L++E + + AL N KEL V RL++EL +++ ++ + L ++ + ++E ++
Sbjct: 984 LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET-ERGEVEEDKE 1042
Query: 1328 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
N E ++ V +C E L+ E + + + + LEE +
Sbjct: 1043 NK---------EYSEKCVTSKCQEI--EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQNQVILEENTTLL 1444
++ KQ NQ L+ T ++ ++A EI+ IQ T + V L + T ++
Sbjct: 1092 ALV---KQMNQTLQDKTNQIDLLQA-EISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147
Query: 1445 G----FQDKHFQHQATIAELELEKTKLQELTRKLKERVT----ILVKQKDVLSHGEKEEE 1496
+H++ + L LEK K ++L +KL+E +T IL K ++ H EE
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEK-EQLQKKLQEALTSRKAILKKAQEKERH--LREE 1204
Query: 1497 LKAMMHD---LQITCSEMQQKVELLRYESEKLQ-QENSILRNEITTLNEEDSISNLKLGT 1552
LK D LQ E ++ E + + +LQ Q + ++ + ++++S S+
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP--- 1261
Query: 1553 LNGSQEEMWQKTE-----------------TVKQENAAVQ--KMVENLKKQISELKIKNQ 1593
G +E +++ TE + ++ +A+Q V +K Q+ E++ +
Sbjct: 1262 --GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319
Query: 1594 QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERC 1653
+L+L+ + + + ++ E++ +L +++ + E E + E E +L+++LE
Sbjct: 1320 ELELKVSSTTSELTKKSEEVFQLQEQINKQ--GLEIESLKTVSHEAEVHAESLQQKLESS 1377
Query: 1654 KVQSSTL-----------------------VSSLEAELSE-----VKIQTHIVQQENHL- 1684
++Q + L VS L +LSE KIQT I++QE+ +
Sbjct: 1378 QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437
Query: 1685 ---------LKDELEKMKQLH-------RCPD--------LSDFQQKISSVLSYNEKLLK 1720
K+ E++KQL + P+ Q+K+ + L ++ LK
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK 1497
Query: 1721 EKEALSEELN---SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNL 1777
E ++L EEL+ +++L KS +A ++ + + + ++ +L QE+ L
Sbjct: 1498 ENKSLQEELSLARGTIERLTKS------LADVESQVSAQNKEKDTVLGRLALLQEERDKL 1551
Query: 1778 -----EDTVQNVNLQMS--RMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT 1830
++N +L S +K L ++KE L +E+ SL K + A W
Sbjct: 1552 ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL-KSSKIAESTEW------ 1604
Query: 1831 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1890
Q+K K ++ + + + E ER+Q +V+ + E K+R E+N
Sbjct: 1605 -------QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
Query: 1891 LPKHQKHLNPSGTM-----------NPTEQEKLSLKRECDQFQKEQSPA--------NRK 1931
++ M +Q+ L L+ E D+ + E PA
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717
Query: 1932 VSQMNSLEQELETIHLENEGLKKK-------QVKLDEQLMEMQH 1968
+S S+++ELE + +E E L KK + L E++ +++H
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH 1761
Score = 194 bits (492), Expect = 1e-48
Identities = 378/1859 (20%), Positives = 780/1859 (41%), Gaps = 241/1859 (12%)
Query: 315 RILDTWQEE--GIENSQEILKALDFSLDGNINLTELTLALENE---LLVTKNSIHQA--- 366
+++D Q+E E +IL ++ N T+ E E +L+ K + A
Sbjct: 273 QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 367 -ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY-- 423
+ + + E+ HLLE+ +Q + + +L S E+ H A +E + +
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ----------KHKAEMEEKTSHIL 382
Query: 424 NLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSL 483
+L+K +E + ALK++ K +LQ +Q ++ Q I++ + D+L
Sbjct: 383 SLQKTGQELQSACDALKDQNSK----LLQDKNEQAVQSAQTIQQ-------LEDQLQQKS 431
Query: 484 KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 543
KE S+ N L + A + + + V E L ++R+ ++
Sbjct: 432 KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASL----------QKRVVELE 481
Query: 544 NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS--EEVEANSGGIEPEHGLGS 601
NE + + +++EL++E E+ +Q +L + + E E + I + +
Sbjct: 482 NE-KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
Query: 602 EECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMK 661
EE + V+E Q H+++ L LE+++ + ++ K Q K
Sbjct: 541 EE--------SGQDVLENTFSQKHKELSVLLLEMKEA---------QEEIAFLKLQLQGK 583
Query: 662 QRHENETHTLE-KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
+ E + L+ K++ ++ E L++ + EE V+ E+ T
Sbjct: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAST- 642
Query: 721 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
+H+ ++ A E L+S+ +K ++ Q HQ++L L
Sbjct: 643 -------EHQSRTSEEISLNDAGVE-----LKSTKQDGDKSLSAVPDIGQCHQDELERL- 689
Query: 781 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
+ LE LE + + QE EK E + S + Q + +K + SA
Sbjct: 690 KSQILE--------LELNFHKAQEIYEKNLDEKAKEISNLN-QLIEEFKKNADNNSSAFT 740
Query: 841 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
+L Q L ++E + + + + +L AEA+ + + + +LT++
Sbjct: 741 ALSEERDQLLSQVKELSMVTELRAQVK--QLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798
Query: 901 EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV 960
L K S V+ + L +L+D++ Q +L+ +L++ L E V
Sbjct: 799 HSLSIEAK----SKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854
Query: 961 LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR 1020
+ E+L SQ L + E+E + Q ++ K +E + + T E D++ E+S ++
Sbjct: 855 RHISSKVEEL-SQALSQKELEITKMDQLLLEKKRDVETLQQ-TIEEKDQQVTEISFSMTE 912
Query: 1021 LQSKIKE--------MQQATSPLSMLQSGCQVIGEEEVEGDGALSL-LQQGEQLLEENGD 1071
++ E ++ L++L S + +E+VE D +S L+Q + G
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLL-SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971
Query: 1072 VLLS-LQRAHEQAVKENVKMATEIS-------RLQQRLQKLEPGLVMSSCLDEPATEFFG 1123
+ LQ + KEN + ++ L QR+ +LE L ++ DE E
Sbjct: 972 ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL--ANLKDESKKEIPL 1029
Query: 1124 NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK--IEESEA 1181
+ E+ E K+ + + + V S ++ E+ + V+ Q ++ +EE A
Sbjct: 1030 SETERGEV----EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 1182 SVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLF--DVSVLKK 1239
+ E F L + + NQI LQ ++ A + D V+++K+
Sbjct: 1086 AEEQFQALVKQMNQTLQ--DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Query: 1240 KLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDE 1299
+ + +S +K ++ + L++E ++ + EAL + K + + +
Sbjct: 1144 TVVISPPCTGSSEHWK---PELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 1300 LKK-MEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASL 1358
L++ +++ + + L++ +DE ENE + + +LQ ++ + + + D
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD------QQ 1254
Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHH---VIEE--C------KQENQYLEGNTQL- 1406
E+ P LEE + + HH V+E C ++ L+G T +
Sbjct: 1255 ESCSSTPG---------LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVA 1305
Query: 1407 -----LEKVKAHEIAWLHGTIQTHQERPRVQNQVI-LEENTTLLGFQD---KHFQHQATI 1457
L++++A ++ T E + +V L+E G + K H+A +
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
Query: 1458 ----AELELEKTKLQ----ELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCS 1509
+ +LE ++LQ E R+L+ ++ L K ++S +KEE++ + L
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQK---LIS--KKEEDVSYLSGQLS---- 1416
Query: 1510 EMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ 1569
+++ L + ++E ++QE+ +++ T L + + ++ L EM QK E + +
Sbjct: 1417 --EKEAALTKIQTEIIEQED-LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473
Query: 1570 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ--- 1626
E+ A Q++ L+ + I ++ EN L ++ S + ++ L + L ++ Q
Sbjct: 1474 ESRAKQQIQRKLQAAL----ISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
Query: 1627 --KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL 1684
KEK+ L ++E+ L E++R +++ +L SS E+ +K+ + ++
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES----LKLALEGLTEDKEK 1585
Query: 1685 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEH 1744
L E+E +K + + +++Q+K + E LL+ E +S E + ++H
Sbjct: 1586 LVKEIESLKS-SKIAESTEWQEKHKELQKEYEILLQSYENVSNE----------AERIQH 1634
Query: 1745 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEA 1804
+ ++QE+ + L+S +E + L++ Q + +M+ + QQ+
Sbjct: 1635 VVEAVRQEK---QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691
Query: 1805 LKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1862
L++E L ++ AG K + + + + + +R+ + ++++ Q L E
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY--ETLSKKFQSLMSEK 1749
Query: 1863 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMN----PTEQEKLSLKRE- 1917
+ L VQ+ K ++ + K LE+ +Q ++ GT + EQ+ LS+
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809
Query: 1918 -CDQFQKEQSPANRKVS-------QMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHL 1969
C + AN VS ++N+ Q+++ + GL++++ K E +++
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869
Query: 1970 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ-------AERINQHLQEELE 2022
++T S +L++LQ++ M Q Q+Q +L + AE L+E L
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQ--QIQEELSRVTKLKETAEEEKDDLEERLM 1927
Query: 2023 NRTSETNTPQGNQEQLVT--VMEERMIEVEQK--LKLVKRLLQEKVNQLKEQVSLPGHL 2077
N+ +E N GN Q VT ++ ++E E K K V L +EK +KE+ + +
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI 1986
Score = 190 bits (482), Expect = 1e-47
Identities = 365/1829 (19%), Positives = 748/1829 (40%), Gaps = 263/1829 (14%)
Query: 370 SFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA-----IERRNEYN 424
S EI+ L E+++ + R +E + +++ ++ S + D+ A E ++E++
Sbjct: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
Query: 425 LRKLDEEYKERI--AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS 482
L K + E ++R AAL N R+++LQ+ + LE+E+ K E + + LS
Sbjct: 983 LLKKENEQRKRKLQAALIN-----RKELLQRVSR----LEEELANLKDES---KKEIPLS 1030
Query: 483 LKENSRLENELLENAEKLAEYENLTNKLQR---NLENVLAEKFGDLD---PSSAEFFLQE 536
E +E + EN E + +T+K Q L+ ++EK +L E E
Sbjct: 1031 ETERGEVEEDK-ENKEYSEKC--VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087
Query: 537 ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
E+ + + + + +Q+D LQ+E+ E +A + L S ++ + +S + E
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQA----IIQKLITSNTDASDGDSVALVKE 1143
Query: 597 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
+ S C + E K + I L E E + ++ L KKA
Sbjct: 1144 TVVISPPCTGSS---------EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194
Query: 657 QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE---EEKKQLQVK 713
QE K+RH L+ E+ + + L+E E + +E ++ +QLQ++
Sbjct: 1195 QE--KERH-------------LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
Query: 714 LEEE------KTHLQE-------------KLRLQHEME--LKARLTQAQASFEREREGLQ 752
+ E T QE K QH + L++ L S + LQ
Sbjct: 1240 VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ 1299
Query: 753 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
V + +L++ E++ L K + EL K+ E Q + Q ++ +E E
Sbjct: 1300 GGT----SVAQIKAQLKEIEAEKV-ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354
Query: 813 CNRRTSQIEAQFQSDCQKVTERCESALQSLEG--RYRQELKDLQEQQREEKSQWEFEKDE 870
+ S Q+ E + + LE + +L +LQ+ +++ + +
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414
Query: 871 LTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRN 930
L+++ A ++ E +++E + TQ EM K + E + + VE ++ Q E++
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIKALHTQ-LEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473
Query: 931 VSETQQSL---LSDQILELKSSHKRELREREEVLCQAGASEQLASQR--LERLEMEHDQE 985
S +Q + L ++ K + K +EE+ G E+L +E ++E
Sbjct: 1474 ESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533
Query: 986 RQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVI 1045
+ ++ +L ++ DR E + S +S ++ T L + +
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Query: 1046 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1105
++ + Q+ + L++ ++LL +++E E ++ + ++Q Q+L
Sbjct: 1594 KSSKIAES---TEWQEKHKELQKEYEILL---QSYENVSNEAERIQHVVEAVRQEKQELY 1647
Query: 1106 PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVR-DLGST 1164
G + S+ ++ TE AEQ +++ K + ++ + + E+D +R ++
Sbjct: 1648 -GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
G ++ + E + + + E ELE +K + L ++ L ++ D S
Sbjct: 1707 GDTAKECMETLLSSNASMKE---ELER----------VKMEYETLSKKFQSLMSEKDSLS 1753
Query: 1225 EKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDV------SRENDCLQEELRMMETR 1278
E+ QDL + K LE + + + E + E D L R +
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813
Query: 1279 YDEALENNKELTAEVFRLQDE----LKKMEEVTETFLSLEKSYDEVK-----IENEELNV 1329
+ ++ ++ F DE L++++++ E LE+ + K +ENE+ +
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873
Query: 1330 L--VLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
L + G+++ LQE V + NL LNQ ++E + RV +
Sbjct: 1874 LSQISTKDGELKMLQEEVTKM-----------NL----------LNQQIQEELSRVTKLK 1912
Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQER---PRVQNQVILEENTTLL 1444
EE K + LE+ +++A L+G+I + + +++N+++ E L
Sbjct: 1913 ETAEEEKDD----------LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNL- 1961
Query: 1445 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1504
+ ++ELE EK +L + K K I + + + +KE K+ +L
Sbjct: 1962 ---------KKCVSELEEEKQQL--VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010
Query: 1505 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLN--EEDSISNLKLGTLNGSQ----- 1557
Q E QQ+V+ L+ + + Q++ S L + L + +S +L++ N +Q
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070
Query: 1558 --------------EEMWQKTETVKQENAAVQKMVENLKKQI-SELKIKNQQLDLENTEL 1602
++ + V +N ++K +++ K+ + S++K K++ L+ +
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQA 2130
Query: 1603 SQKNSQNQEKLQELNQRLTEMLCQKEKEPG--NSALEEREQEKFNLKEELERCKVQSSTL 1660
+K+ + ++ +QE L E+ G L ++++E L+E L+ Q +
Sbjct: 2131 EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF 2190
Query: 1661 VSSL------------EAELSEVKIQTHIVQQENHL---------LKDELEK----MKQL 1695
S+ EA+ E K I +E + LKD+L + M++L
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250
Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKEK--EALSEELNSCVDKLAKSSLLEH----RIATM 1749
+ ++I + E L++K + L E + +L ++ L H +A +
Sbjct: 2251 KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL 2310
Query: 1750 KQEQKSWEHQSASLKSQLVASQEKVQNLED-------TVQNVNLQMSRMKSDLRVTQQEK 1802
+ E KS + Q L + L +E+ NLE +QN ++++DL+ +++
Sbjct: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT 2370
Query: 1803 EALKQEV-MSLHKQLQNAGGKSWAPEIA------THPSGLHNQQKRLSWDKLDHL-MNEE 1854
L +E+ M K + GK A ++A H + + LS ++ +++ + EE
Sbjct: 2371 SRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEE 2430
Query: 1855 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSL 1914
+ + +L ++ K E + ++ ++ G E+ LS+
Sbjct: 2431 NKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSI 2490
Query: 1915 KRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLME-MQHLRSTA 1973
E DQ +E + N N L++E+ + + L + KLD +L++ + L
Sbjct: 2491 ILEKDQLIQEAAAEN------NKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544
Query: 1974 TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQG 2033
T S L++ QQ + ++ +L+ +L ++E N+ L+ N Q
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKEL--ENKYAKLEEKLKESEEANEDLRRSF-------NALQE 2595
Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE 2062
++ L +E + + Q + V L +E
Sbjct: 2596 EKQDLSKEIESLKVSISQLTRQVTALQEE 2624
Score = 177 bits (448), Expect = 1e-43
Identities = 380/1859 (20%), Positives = 758/1859 (40%), Gaps = 311/1859 (16%)
Query: 409 EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKA 468
E+++ A+E+ E +KL E R A LK KER L +E+++
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH------------LREELKQQ 1208
Query: 469 KTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS 528
K + N ++++ KEN + ++L + ++ E++ KL + L+
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQL--QIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
Query: 529 SAEFFLQEERLTQMRNE---------YERQCRVLQD--QVDELQSELEEYRAQGRVLRLP 577
F E+ TQ E + LQ V +++++L+E A+ L L
Sbjct: 1267 L--FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELK 1324
Query: 578 LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI------CCL 631
+ ++ SE + + + + E+ N + IE+ + E H + L
Sbjct: 1325 VSSTTSELTKKSEEVFQLQ-----EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379
Query: 632 RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 691
++ + +R + +LDE K +E++ + E ++ ++ EI E +
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYL-SGQLSEKEAALTKIQTEIIEQEDLIKA 1438
Query: 692 LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA-QASFEREREG 750
L H+E KQLQV+L E K +E + E K ++ + QA+ +E
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEE---IGEESRAKQQIQRKLQAALISRKEA 1495
Query: 751 LQSSAWTEEKV---RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE 807
L+ + +E++ RG + L + + + S V EK+ + L LQE R+
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLAL-----LQEERD 1549
Query: 808 KMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG------RYRQELKDLQEQQREEK 861
K+ TE +R S +E Q ++ CES +LEG + +E++ L+ + E
Sbjct: 1550 KLITEMDR--SLLENQ------SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601
Query: 862 SQWEFEKDELTQE----CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE 917
++W+ + EL +E + + E + + V +++E+ K N E
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661
Query: 918 RQ--QLLQDLEDLRNVSETQQSLLSDQILELKSSHKR----------ELREREEVLCQAG 965
+Q + Q++E+++ +ILEL+ + R +E E L +
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721
Query: 966 ASEQLASQRLERLEMEHD---QERQEMMSKLLAME------------NIHK-ATCETADR 1009
AS + + LER++ME++ ++ Q +MS+ ++ N+ K A E ++
Sbjct: 1722 ASMK---EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEK 1778
Query: 1010 ERAEMSTEISRLQSKIKEMQQATSPLSM------------LQSGCQVIGEEEVEGDGALS 1057
+ + QS E ++ S LSM +S + ++ D +
Sbjct: 1779 HDNQTNVTEEGTQSIPGETEEQDS-LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837
Query: 1058 LLQQGEQLLEENGDVLLSLQRAHE-QAVKENVK--MATEISRLQQRLQKLEPGLVMSSCL 1114
LQQ +QL E + Q+ E EN K + ++IS L+ L+ + + L
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897
Query: 1115 DEPATEFFGN------TAEQTEPFLQQNRTKQV-----------EGVTRRHVLSDLEDDE 1157
++ E TAE+ + L++ Q+ + VT + ++L + E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
Query: 1158 VRDLGSTGTSSVQRQEVKIEE-----SEASVEGFSELENSEE---TRTESWELKNQISQL 1209
+++L + + ++ ++E SE E +++ +++ ++ + EL+ + +
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEK 2017
Query: 1210 QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK---------------- 1253
Q+++ L DC R EK +S L++ +K LE + S K
Sbjct: 2018 QQEVKQLQKDCIRYQEK-------ISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070
Query: 1254 ---------YKLLYEDVSREND-CLQEELRMMETRYDEALENNKELTAEVFRLQDE--LK 1301
+K+L +D E L + L++ + L++NKE + +DE +
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKE-----LQSNKESVKSQMKQKDEDLER 2125
Query: 1302 KMEEVTETFLSLEKSYDE---------VKIENE--ELNVLVLRLQGKIEKLQESVVQRC- 1349
++E+ E L +K+ E V +E E+ V + + ++++LQE++
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL-- 1407
+ S+ +L+ + D + ++E R I+ ++E + E N +L
Sbjct: 2186 QLAAFTKSMSSLQDDRD-------RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238
Query: 1408 ---------EKVKA------HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKH 1450
E++K H+ QT + + + EN LL + +H
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298
Query: 1451 FQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSE 1510
H + + E KL+ + LK+++T D+ + EK +E K +L+ +
Sbjct: 2299 LYHSS-----QNELAKLESELKSLKDQLT------DLSNSLEKCKEQKG---NLEGIIRQ 2344
Query: 1511 MQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQE 1570
+ ++ ++ E+L+ + R + L+EE ++ K+ +L +EE Q
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ-------- 2396
Query: 1571 NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE 1630
A+ ++ + K+I EL+ Q + EN L ++N + +K +L + L + +KE
Sbjct: 2397 -VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI--KKENI 2453
Query: 1631 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKD 1687
+ L+ + +L+ + +R L E LS + + ++Q+ EN+ LK+
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE---ERHLSIILEKDQLIQEAAAENNKLKE 2510
Query: 1688 ELEKMKQLHRCPDLSDFQQKISS-VLSYNEKL---LKEKEALSEELNSCVDKLAKSSLLE 1743
E+ ++ DL+ K+ + ++ Y E L + K++ ++L +L ++ LE
Sbjct: 2511 EIRGLRS--HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV--QLQQNKELE 2566
Query: 1744 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-- 1801
++ A ++++ K E + L+ A QE+ Q+L ++++ + +S++ + Q+E
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626
Query: 1802 ----KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL 1857
LK + +H+ +A S IA L QK + + E +
Sbjct: 2627 LGLYHAQLKVKEEEVHR--LSALFSSSQKRIAELEEELVCVQKEAA-----KKVGEIEDK 2679
Query: 1858 LWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1917
L +E + L + E + E+V +L +L+ QK L + + S R
Sbjct: 2680 LKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRS 2739
Query: 1918 CDQFQKEQSPANRKVSQM-NSLEQEL-ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATP 1975
Q + AN ++ ++ + L E L+ +GL ++ D L E ++
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE--RDALLSETAFSMNSTEE 2797
Query: 1976 SPSPHAWDLQLLQQQACPMVPREQFLQLQRQL----------------LQAERINQHLQE 2019
+ H L+ L QQ + EQ L L QL LQ ER HL
Sbjct: 2798 NSLSH---LEKLNQQL--LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER--DHLWN 2850
Query: 2020 ELE----------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQE--KVNQ 2066
ELE ++ +T + L M + ++ LK +K L Q+ ++NQ
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Score = 141 bits (355), Expect = 8e-33
Identities = 291/1452 (20%), Positives = 573/1452 (39%), Gaps = 215/1452 (14%)
Query: 421 NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
N Y L+++D+ KERIA L+ E +K +E Q ++ L +I E +++ +
Sbjct: 1836 NNY-LQQIDQ-LKERIAGLEEEKQKNKE-FSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
N +++ EL + E + L+ L N LAE G + + Q+
Sbjct: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN-----YCQDVTDA 1947
Query: 541 QMRNEY-ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGL 599
Q++NE E + + L+ V EL+ E ++ +K E E +E G
Sbjct: 1948 QIKNELLESEMKNLKKCVSELEEEKQQL----------VKEKTKVESEIRKEYLEKIQGA 1997
Query: 600 GSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 659
E N + EL+ E+ +E C+R + +K+ L+ TV + + Q
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ--EKI----SALERTVKALEFVQTE 2051
Query: 660 MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEAT---CRHEEEKKQLQVKLEE 716
++ E L + + K AEL +L + EA + + KK+LQ E
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 717 EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQE-- 774
K+ +++K + +L+ RL QA+ +E++ +Q EK+ L +E +
Sbjct: 2112 VKSQMKQK-----DEDLERRLEQAEEKHLKEKKNMQ------EKLDALRREKVHLEETIG 2160
Query: 775 QLTSLVEKHTLEKEELRKEL---------LEKHQRELQEGREKMETECNRRTSQIEAQFQ 825
++ + K E ++L++ L K LQ+ R+++ E + + Q
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
Query: 826 SDCQKVTERCESALQSLEGRYRQ------ELKDLQEQQREEKSQWEFEKDELTQECAEAQ 879
S +++ + E L+ + RQ ELK + +K WE + Q + Q
Sbjct: 2221 SKEEEIRLK-EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK----AQTEVQLQ 2275
Query: 880 ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET----- 934
+ + +TL+ E L +E L + + L + E + L L DL N E
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335
Query: 935 --------------QQSLLSDQILELKSSHKRELRER---------EEVLCQAGASEQLA 971
Q S S + LE REL R ++++ E+
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI 2395
Query: 972 SQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE--MQ 1029
+ L +HD+E +E+ LL+ E E +++ + + ++ IK+ +Q
Sbjct: 2396 QVAIAELRQQHDKEIKEL-ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454
Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK 1089
Q S ++S + + + ++ +QL E + ++L + ++A EN K
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRD-------RIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 1090 MATEISRLQQRLQ-------KLEPGLVM-SSCLDEPATEFFGNTAEQTEPFLQQNRTKQV 1141
+ EI L+ + KL+ L+ L++ T + E LQQN+ +
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 1142 EGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWE 1201
+ L + E+ DL + + + ++ +E E+ S+L E
Sbjct: 2568 KYAKLEEKLKESEEAN-EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626
Query: 1202 LKNQISQL---QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1258
L +QL +E++ L A + ++ +L ++ ++K+ +++ E K K
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA--KKVGEIEDKLKKEL 2684
Query: 1259 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF----LSLE 1314
+ + + ++ E E R E + E+ ++ + E K + ++F SL+
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ 2744
Query: 1315 KSYDEVKIENEELN---------VLVLRLQGKIEKLQESVVQRCDCCL---WEASLENLE 1362
S D E +EL + L+ QG + + +++++ + E SL +LE
Sbjct: 2745 NSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLE 2804
Query: 1363 ------IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA 1416
+ D +L L+ LE+ +V+S + + E +L LEK + E
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE---LEKFRKSEEG 2861
Query: 1417 WLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKE 1476
Q VQ+ + + ++L +D+ L E LQ+ ++ +
Sbjct: 2862 KQRSAAQPSTSPAEVQS--LKKAMSSLQNDRDR----------LLKELKNLQQQYLQINQ 2909
Query: 1477 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1536
+T L H L+ E Q K + + E+L+QEN ++E+
Sbjct: 2910 EITEL--------------------HPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949
Query: 1537 TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE---LKIKNQ 1593
L E S + + +E+ Q+ + +Q ++ L+ S+ LK++ Q
Sbjct: 2950 HQLRMEKSSWEIHERRM---KEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006
Query: 1594 QLDLENTELSQKNSQN----------------------QEKLQELNQRLTEMLCQK---- 1627
+ T S SQN + ++Q+LN +++L +K
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLS 3066
Query: 1628 -EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL-L 1685
+ + +L E +Q +L L C V V L+A + + Q++N +
Sbjct: 3067 IQLCDTSQSLRENQQHYGDL---LNHCAVLEKQ-VQELQAGPLNIDVAPGAPQEKNGVHR 3122
Query: 1686 KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHR 1745
K + E++++ + S+ QQ++ + +++ + ++ L EE + V S+ E +
Sbjct: 3123 KSDPEELREPQQ--SFSEAQQQLCNT---RQEVNELRKLLEEERDQRVAAENALSVAEEQ 3177
Query: 1746 IATMKQEQKSWE 1757
I + E W+
Sbjct: 3178 IRRL--EHSEWD 3187
Score = 131 bits (330), Expect = 6e-30
Identities = 288/1451 (19%), Positives = 590/1451 (40%), Gaps = 227/1451 (15%)
Query: 313 VERILDTWQEEGIENSQEILKALDFSLDGNIN--LTELTLA-LENELLVTKNSIHQAALA 369
V ++ +T +EE + + ++ L L+G+I ++T A ++NELL ++ +
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLA-ELNGSIGNYCQDVTDAQIKNELL-------ESEMK 1959
Query: 370 SFKAEIRHLLERVDQVVREKEKLRSDLDK--AEKLKSLMASEVDDHHA----AIERRNEY 423
+ K + L E Q+V+EK K+ S++ K EK++ + HA + + +
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019
Query: 424 NLRKLDEE---YKERIAAL----------KNELRKERE---QILQQAGKQRLELEQEIEK 467
+++L ++ Y+E+I+AL + E +K+ E + L QA + R + + E+
Sbjct: 2020 EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 468 AKTEENYIRDRLALSLKENSRLENELLENAEKLAEY-----ENLTNKLQRNLENVLAEKF 522
K + + A L +N +L+ EL N E + E+L +L++ E L EK
Sbjct: 2080 FKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139
Query: 523 G---DLDPSSAEFFLQEERLTQMR---NEYERQCRVLQDQVDELQSELEEYRA------- 569
LD E EE + +++ N+ +++ + LQ+ +D ++L +
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 570 -QGRVLRLPLK--NSPSEEVEANSGGIEPEHGLGSEECNPL-----NMSIE-AELVIEQM 620
+ RV+ K S+ +++ E E L + C+ L MSI EL I
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255
Query: 621 KEQHHRDI----CCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQIS 676
+ +H + I ++L+ KV + ++ ++S + ++ +NE LE ++
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK 2315
Query: 677 DLKNEIAELQGQAAVLKE--AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELK 734
LK+++ +L KE + E R +E Q + ++ Q + LQ EL
Sbjct: 2316 SLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ-----NSKFSYEQLETDLQASRELT 2370
Query: 735 ARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL 794
+RL + E++ L S EE ++ EL Q H +++ L E ++EE L
Sbjct: 2371 SRLHEEINMKEQKIISLLSG--KEEAIQVAIAELRQQHDKEIKEL-ENLLSQEEEENIVL 2427
Query: 795 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 854
E++++ + + + MET + I+ + Q D + S+LQ+ R + + L+
Sbjct: 2428 EEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS---FVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 855 EQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSM 914
E+ EKD+L QE A LKE ++ ++ L E L+
Sbjct: 2485 ERH----LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLD---------- 2530
Query: 915 VVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQR 974
E Q +DL + + ++QQ Q+LE++ +EL + +
Sbjct: 2531 -AELIQYREDLNQVITIKDSQQK----QLLEVQLQQNKELENK--------------YAK 2571
Query: 975 LERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP 1034
LE E ++ +++ A++ E+ ++S EI L+ I ++ + +
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQ-----------EEKQDLSKEIESLKVSISQLTRQVTA 2620
Query: 1035 LSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEI 1094
L + +G L L ++ EE E +++
Sbjct: 2621 L---------------QEEGTLGLYHAQLKVKEE-----------------EVHRLSALF 2648
Query: 1095 SRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE 1154
S Q+R+ +LE LV C+ + A + G ++ + L+ G+ R ++
Sbjct: 2649 SSSQKRIAELEEELV---CVQKEAAKKVGEIEDKLKKELK--HLHHDAGIMRNE--TETA 2701
Query: 1155 DDEVRDLGSTGTSSVQRQEVKIEESE---ASVEGFSELENSEETRTESWELKNQISQLQE 1211
++ V +L Q+ + +E++ A ++ F +S L+N E
Sbjct: 2702 EERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS---------LQNSRDHANE 2752
Query: 1212 QLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEE 1271
+L D K L +++ LK++ +L R +A LL E N +
Sbjct: 2753 EL-------DELKRKYDASLKELAQLKEQ-GLLNRERDA-----LLSETAFSMNSTEENS 2799
Query: 1272 LRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV 1331
L +E + L +++L +L+D +++ ++ SL+ D + E E+
Sbjct: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR--- 2856
Query: 1332 LRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV---PRVRSVHH 1388
+GK + + + ++ +L+ + D + +L ++ + + +H
Sbjct: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHP 2916
Query: 1389 VIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERP--RVQNQVILEENTTLLGF 1446
+ + ++ + + E+++ ++W H Q E+ + + + E+ +
Sbjct: 2917 LKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISD 2976
Query: 1447 QDKHFQH-QATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQ 1505
+D+ H Q I EL ++ Q L + + + + + G + ++++ +
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQAS---PETSASPDGSQN-----LVYETE 3028
Query: 1506 ITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTE 1565
+ +++ ++ + + ++QQ NS + L EE + +++L + S E Q
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLNS----NFSQLLEEKNTLSIQLCDTSQSLRENQQHYG 3084
Query: 1566 TVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN----SQNQEKLQELNQRLT 1621
+ A L+KQ+ EL+ +D+ +KN + E+L+E Q +
Sbjct: 3085 DLLNHCAV-------LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFS 3137
Query: 1622 E---MLCQKEKEPG--NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1676
E LC +E LEE ++ + L + Q L S E + S I
Sbjct: 3138 EAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHS-EWDSSRTPIIGS 3196
Query: 1677 IVQQENHLLKD 1687
QE LL D
Sbjct: 3197 CGTQEQALLID 3207
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 200 bits (509), Expect = 1e-50
Identities = 408/1927 (21%), Positives = 803/1927 (41%), Gaps = 278/1927 (14%)
Query: 310 HASVERILDTWQEEGIENSQEILKALDFSLDGNIN-LTELTLALENELLVTKNSIHQAAL 368
+ +E + +Q + +E +++ L+ L N +T+LT ++ + V K+ + L
Sbjct: 662 YKQMENDIQLYQSQ-LEAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDLLCNLEL 718
Query: 369 ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY----- 423
+ +I L + +++ V E E LR ++ +LKSL SEV+ I+ ++E
Sbjct: 719 ---EGKITDLQKELNKEVEENEALREEVILLSELKSL-PSEVERLRKEIQDKSEELHIIT 774
Query: 424 -NLRKLDEE--YKE-RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRL 479
KL E +KE R+ L E+ K ++ + + +QE + KT +
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK-STDQEFQNFKTLHMDFEQKY 833
Query: 480 ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 539
+ L+EN R+ E++ +++ ++++ L+ L + K +L + E + +
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL----SYKTQELQEKTREVQERLNEM 889
Query: 540 TQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG- 598
Q++ + E + LQ E + L + Q + + ++++ ++ E
Sbjct: 890 EQLKEQLENRDSTLQTV--EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 599 LGSEECNPLNMSIEAELVIEQMKE---QHHRDICCLRLELEDKVR---HYEKQLDETVVS 652
L S+ + +NM+I+ + + E QH I L+ ++ ++V H E+ ET
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 653 CKKAQENMKQRHENETHTLEKQISDLK-NEIAELQGQAAVLKEAHHEATCRHEE---EKK 708
++ + ++ + E + +D+K NEI E Q + L + +E E EK+
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 709 QLQVKLEEE---KTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSS-----AWTEE 759
QL+ L+E QE+LRL E++ + + + + ++EG S A EE
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 760 KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
K++ +Q+L++ Q+ L E ++K+ E L+ + + E METE +
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 820 IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ---ECA 876
+ ++ ER L+ L+ + E L+ RE ++ K+EL
Sbjct: 1188 LNENYEEVKSITKER--KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK 1245
Query: 877 EAQELLKETLKR--EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 934
E QE + E + EKT ++ TQ+ E +E + ++ E Q+LL ++++ VSET
Sbjct: 1246 EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI-PVLHEEQELLPNVKE---VSET 1301
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM-EHDQERQEMMSKL 993
Q+++ ++L +S+ K S LA +ERL + E QE QE + L
Sbjct: 1302 QETMNELELLTEQSTTKD--------------STTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSG---CQVIGEEE 1049
+ K E + + ++ I +KI+E Q + L+M + +++ E E
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407
Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
+LL+ ++L + LQ +H++ +K K ++ RLQ+ LQ
Sbjct: 1408 QFKPKDSALLRIEIEML----GLSKRLQESHDE-MKSVAKEKDDLQRLQEVLQS------ 1456
Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1169
S L E E E E + + + T + +L + E T S++
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE------TEISTI 1510
Query: 1170 QRQEVKIEESEASVEGFSELENSEETRTESWELKN--QISQLQEQLMMLCADCDRASEKK 1227
Q+Q I + +L+N + E E N QIS++QE++ L + K
Sbjct: 1511 QKQLEAIND---------KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561
Query: 1228 QDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNK 1287
L S+ K L++ R+ E+ + +++ ++ E +QE L++ D+ EN K
Sbjct: 1562 SALQ---SIESKMLELTNRLQESQEEIQIMIKE-KEEMKRVQEALQIER---DQLKENTK 1614
Query: 1288 ELTAEVFRLQD---ELKKMEEVTET------FLSLEKSYDEVKIENEELNVLVLRL---- 1334
E+ A++ Q+ + KM V ET L++ ++ K+ E + +RL
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674
Query: 1335 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1394
+E+++ +R D E E L++E D QL + L E + R EE K
Sbjct: 1675 HENLEEMRSVTKERDDLRSVE---ETLKVERD----QLKENLRETITRDLEKQ---EELK 1724
Query: 1395 QENQYLEGNTQLLEKV------KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQD 1448
+ +L+ + + ++K+ K +EI+ + ++ + + Q+ I EE L
Sbjct: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE----LRIAH 1780
Query: 1449 KHF-QHQATI------------------AELELEKTKLQELTRKLKERVTILVKQKDVLS 1489
H + Q TI +LE KLQE ++LK L+ K ++
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840
Query: 1490 HGEKE----EELKAMMHDLQITCSEMQ-------QKVELLRYESEKLQQENSILRNEITT 1538
+K+ E+LK + D +T S+++ QK+ E + + +E LR T
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900
Query: 1539 LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1598
L E L E+ Q+ +T + + ++ V+ L+++ISE K Q+
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE---KTIQISDI 1957
Query: 1599 NTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEEREQEKFNLKEE---LERCK 1654
+L + + Q+K+QEL ++ ++L KE + + E EQ K + + ++ +
Sbjct: 1958 QKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017
Query: 1655 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ---LHRCPDLSDFQQKISSV 1711
+ + L L L E++ IV +E +DEL ++K+ + R ++ ++ I+
Sbjct: 2018 MDNFQLTKKLHESLEEIR----IVAKE----RDELRRIKESLKMERDQFIATLREMIARD 2069
Query: 1712 LSYNEKLLKEKEALSEE----LNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
N ++ EK LS+ S +K ++ L R + M + S L+ ++
Sbjct: 2070 -RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128
Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE 1827
+E ++ + LQ ++ Q+ E + K+L+ S+ +
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQR----CSMEFHRIMKKLKYV--LSYVTK 2182
Query: 1828 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE---------NERLQTMVQNTKAELTH 1878
I H + D +D + +++ L+ + + L+ + N +L H
Sbjct: 2183 IKEEQ---HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL-H 2238
Query: 1879 SREKVRQLESNLLP----KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1934
E ++ + P + Q+ L+ M +E L+ + + ++ + N ++ Q
Sbjct: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298
Query: 1935 MNSL--------------------------EQELETIHLENEGLKKKQVKLDEQLMEMQH 1968
+N+ EQ+L+++ +NE L K L L
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ 2358
Query: 1969 LRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH-------LQEEL 2021
+ T + +PH + E+ +L+ L +A+ H +Q+EL
Sbjct: 2359 VNPTTQDNKNPHV-------TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL 2411
Query: 2022 E----------NRTSETNTPQGNQEQLVTVMEERMI--------EVEQ-KLKLVKRLLQE 2062
E + E+N ++ + V+++++ E+E K+KLVK L E
Sbjct: 2412 EVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDL-E 2470
Query: 2063 KVNQLKE 2069
K+ KE
Sbjct: 2471 KMKNAKE 2477
Score = 194 bits (492), Expect = 1e-48
Identities = 399/1970 (20%), Positives = 812/1970 (41%), Gaps = 407/1970 (20%)
Query: 383 DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 442
+ + E LR+D D + +E ++ ++ +N+ LDE AL+ +
Sbjct: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKND-----LDE-----FEALERK 543
Query: 443 LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 502
+K++E ++L EI K N ++ N LENEL E L E
Sbjct: 544 TKKDQE----------MQLIHEISNLK---NLVKHAEVY----NQDLENELSSKVELLRE 586
Query: 503 YENLTNKLQ-----RNLENVLAEKFGDL----DPSSAEFFLQEERLTQMRNEYERQCRVL 553
E+ KLQ + LEN+ + L DP + L + + + +R+ L
Sbjct: 587 KEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL--DAKRESAFL 644
Query: 554 QDQVDELQSELEEYRAQGRVLR--LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI 611
+ + EL+ +++E + + + L S E + +E E E L I
Sbjct: 645 RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI 704
Query: 612 EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE----NE 667
+ ++ +D+ C LELE K+ +K+L+ K+ +EN R E +E
Sbjct: 705 DGKV---------PKDLLC-NLELEGKITDLQKELN------KEVEENEALREEVILLSE 748
Query: 668 THTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE----------- 716
+L ++ L+ EI + + ++ + ++ ++Q LEE
Sbjct: 749 LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808
Query: 717 --------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT----- 757
+ H+ + + + +E R+ Q + +E + SS
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868
Query: 758 -------EEKVRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELL-EKHQRELQE--- 804
+EK R + + L + Q EQL + TL+ E K L+ EK Q+ L+E
Sbjct: 869 SYKTQELQEKTREVQERLNEMEQLKEQLEN--RDSTLQTVEREKTLITEKLQQTLEEVKT 926
Query: 805 -GREKMETECNRRTSQIEA-QFQSDCQKVT-------ERCESALQSLEGRYRQELKDLQE 855
+EK + + + + QIE Q +SD E+ +AL+SL+ ++++ + L+
Sbjct: 927 LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK-QHQETINTLKS 985
Query: 856 QQREEKSQWEFEKDELTQECAEAQELL-----KETLKREKTTSL--------VLTQEREM 902
+ EE S+ ++ + E Q+ + K+ L+ + T +L ++ Q+R++
Sbjct: 986 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045
Query: 903 L-----EKTYKEHLNSMVVERQQLLQDL-EDLRNVSETQQS--LLSDQI---LELKSSHK 951
+ ++ L S++ E++QL DL E++ E Q+ LL D++ E+ + K
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105
Query: 952 RELREREEVLCQ-----AGASEQL--ASQRLERLE---MEHDQERQEMMSKLLAMENI-- 999
++E L + A E+L SQ+L+ + + +E EM K+ +EN+
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165
Query: 1000 ----HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE------EE 1049
+ T E + ER E++ +++ ++K + + L LQ + + E
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225
Query: 1050 VEGDGALSLLQQGEQL------LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1103
+E G LQ E+L L+E+ + + L+R+ + + + ++ + +LQ+
Sbjct: 1226 IEATG----LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN-TQDLEKSHTKLQE 1280
Query: 1104 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGS 1163
P L E N E +E Q ++E +T + D S
Sbjct: 1281 EIPVL-------HEEQELLPNVKEVSE---TQETMNELELLTEQSTTKD----------S 1320
Query: 1164 TGTSSVQRQEV----KIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
T + ++ + + K +ES+ ++ ++ ++ +T E+ E+K+ QL+E + A
Sbjct: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH--DQLKEHIRETLAK 1378
Query: 1220 CDRASEKKQDLL---------------------FDVSVLKKKLKML---ERIPEASPKYK 1255
+ K++ L D ++L+ +++ML +R+ E+ + K
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK 1438
Query: 1256 LLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK--------KMEEVT 1307
V++E D LQ ++++ D+ EN KE+ A+ ++ELK + E +
Sbjct: 1439 ----SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494
Query: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP-- 1365
E ++L + E+ ++L + +LQ KI+++ E Q + E + E++
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554
Query: 1366 -------------DGNILQLNQTLEECVPRVRSVHHVIEECK--------QENQYLEGNT 1404
+ +L+L L+E ++ + EE K + +Q E
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614
Query: 1405 QLLEKVKAH---------------------EIAWLHGTIQTHQ------ERPRVQNQVIL 1437
+++ K+K EI L +T + E ++ IL
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674
Query: 1438 EENTTLLGFQDKHFQHQATIAE-LELEKTKLQE-----LTRKLKERVTILVKQKDVLSHG 1491
EN + K ++ E L++E+ +L+E +TR L+++ + + + H
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQ 1734
Query: 1492 EKEEELKAMMHDLQITCSEMQQKVE----LLRYESEKLQQENSI----LRNEITTLN--- 1540
E ++L+ ++ + S MQ+ +E L+ + K+Q+E I L+ + T++
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR 1794
Query: 1541 -----EEDSISNLK--LGTLNGSQEEMWQKTE-------TVKQENAAVQKMV---ENLKK 1583
+ D +SN++ L N +E Q+ + T+K++ QK V E LKK
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQEL-----NQRLTEMLCQKEKEPGNSALEE 1638
QI + + +L++EN L+QK +N E+++ + N R E + E++ +L+E
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914
Query: 1639 REQEKFNLKEELERCKVQS---STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1695
+ +++EL+ ++ S V L ++SE IQ +Q++ KDEL+K
Sbjct: 1915 TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK---- 1970
Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS 1755
KI + +LL+ KE + ++ +I M+Q +K
Sbjct: 1971 -----------KIQELQKKELQLLRVKEDV--------------NMSHKKINEMEQLKKQ 2005
Query: 1756 WEHQSASLKSQLVASQEKVQNLEDTVQNVNL------QMSRMKSDLRVTQQEKEALKQEV 1809
+E Q+ S++S + + + + L ++++ + + ++ R+K L++ + + A +E+
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 1810 MSLHKQLQNAGGKSWAPEIATHPSGLHN--QQKRLSWDKLDHLMNEEQQLLWQENERLQT 1867
++ +Q PE G + + R ++ L+ + + E L
Sbjct: 2066 IARDRQNHQV-----KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE-MDDHYECLNR 2119
Query: 1868 MVQNTKAELTHSREKVRQLESNL-LPKHQ-KHLNPSGTMNPTEQEKLSLKRECDQFQKEQ 1925
+ + + E+ +E ++++NL LP Q KH+ T N +R +F +
Sbjct: 2120 LSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTAN---------QRCSMEFHRIM 2170
Query: 1926 SPANRKVSQMNSL-EQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDL 1984
+S + + E++ E+I+ + K E L+++QHL+ PS DL
Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDC-DVPSRELRDL 2229
Query: 1985 QLLQ------QQACPMVPREQF----LQLQRQLLQAERINQHLQEELENRTSETNTPQGN 2034
+L Q ++ +F + Q+ L + + Q L+E L R G
Sbjct: 2230 KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289
Query: 2035 QEQ--------------LVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
Q++ ++ +M E E E++ + + ++ + LKE+
Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNE-STEFEERSATISKEWEQDLKSLKEK 2338
Score = 164 bits (414), Expect = 1e-39
Identities = 356/1708 (20%), Positives = 715/1708 (41%), Gaps = 300/1708 (17%)
Query: 353 ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL--------DKAEKLKS 404
+NE++ + I +L K E++ +LE V+ EKE+L++DL + E+L+
Sbjct: 1035 DNEIIEQQRKIF--SLIQEKNELQQMLE---SVIAEKEQLKTDLKENIEMTIENQEELR- 1088
Query: 405 LMASEVDDHHAAIERRNEYNLRKLDEEYK--ERIAALKNELRKEREQILQQAGKQRLELE 462
L+ E+ + + + ++K E + +R+A ++ +L KE+ Q LQ+ +Q L ++
Sbjct: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL-KEKSQQLQEKQQQLLNVQ 1147
Query: 463 QEIEKAKTEENYIRDRLALSLKENS----RLENELLENAEKLAE-YENLTNKLQRNLENV 517
+E+ + + + N I + L LK +E E LE A+KL E YE + + +
Sbjct: 1148 EEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK 1206
Query: 518 LAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL-----QDQVDELQSELEEYRAQGR 572
+K + + +++E T ++ + E + + Q+ +DEL+ + E AQ
Sbjct: 1207 ELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ-- 1264
Query: 573 VLRLPLKNSPSEEVEANSGGIEPEHGL------GSEECNPLNMSIEAELVIEQMKEQHHR 626
++ +++ + E L SE +N E EL+ EQ +
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN---ELELLTEQSTTKDST 1321
Query: 627 DICCLRLELEDKVRHYEK--QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 684
+ R+E+E ++R EK + E + S K ++N+K E LE + LK I E
Sbjct: 1322 TLA--RIEME-RLRLNEKFQESQEEIKSLTKERDNLKTIKE----ALEVKHDQLKEHIRE 1374
Query: 685 LQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 744
+ + ++ E++ + ++ E E+ ++ L+ E+E+ + Q S
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 745 EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKE---LLEKHQ-- 799
+ + + + L E +Q +E + +V KH +EEL+ L E+ +
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQL-KENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493
Query: 800 RELQEGREKMETECNRRTSQIEA---QFQSDCQKVTERCE-------------------- 836
EL+ + ETE + Q+EA + Q+ Q++ E+ E
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF 1553
Query: 837 --------SALQSLEGRYRQELKDLQEQQRE------EKSQW-------EFEKDELTQEC 875
SALQS+E + + LQE Q E EK + + E+D+L +
Sbjct: 1554 KEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613
Query: 876 AEAQELLKETLKRE----KTTSLVLTQER----EMLEK---TYKEHLNSMVVERQQLLQ- 923
E +KE+ ++E K T++ TQE+ E L++ T K +L ++ E +L Q
Sbjct: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673
Query: 924 ---DLEDLRNVSETQQSLLS---------DQILE-LKSSHKRELREREEVLCQAGASEQL 970
+LE++R+V++ + L S DQ+ E L+ + R+L ++EE+ ++
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL--------KI 1725
Query: 971 ASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAE---MSTEISRLQSKIKE 1027
L+ + D+ R + K + N+ K + D +A+ + E+ +KE
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785
Query: 1028 MQQATSPL-SMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1086
Q+ L ++ + + + + + + LQ+ Q L+ N L++L++ V E
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD----VNE 1841
Query: 1087 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGV 1144
K +E+ +L+++++ + L +S E N A++ L++ ++ K+ + +
Sbjct: 1842 TQKKVSEMEQLKKQIK--DQSLTLSKLEIENL-----NLAQKLHENLEEMKSVMKERDNL 1894
Query: 1145 TRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKN 1204
R LE D++++ QE K + E E + S+E + +L+
Sbjct: 1895 RRVEETLKLERDQLKE---------SLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945
Query: 1205 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE 1264
+IS+ Q+ + D D++ ++ Q + ++ KK+L++L + + +K + E +
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQ--KKELQLLRVKEDVNMSHKKINEMEQLK 2003
Query: 1265 NDCLQEELRMMETRYD-----EALENNKELTAEVFRLQDELKKMEE-----------VTE 1308
+ L M R D + L + E V + +DEL++++E
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLR 2063
Query: 1309 TFLSLEKSYDEVKIENEELNV----LVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIE 1364
++ ++ +VK E L+ L L+ K +++E + + + L L ++
Sbjct: 2064 EMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD 2123
Query: 1365 PDGNI-----LQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLH 1419
+ I L + +P +++ H IE+ NQ + K + ++++
Sbjct: 2124 LEKEIEFQKELSMRVKANLSLPYLQTKH--IEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181
Query: 1420 GTIQT-HQERPRVQNQVILE-ENTTLLGFQDKHFQHQATIAELELEKTKL--------QE 1469
+ H+ + + I E E L + +H Q + EL KL +E
Sbjct: 2182 KIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEE 2241
Query: 1470 LTRKLKERV--TILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + E +I + + VLS+ +E+ + + T ++++ ++ E++++ Q
Sbjct: 2242 ILKDFSESEFPSIKTEFQQVLSN---RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI-S 1586
N+ N I + E + + T++ +E Q +++K++N + K + LK + S
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATIS---KEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355
Query: 1587 ELKIKNQQLDLENTELSQKNSQ-NQEKLQELNQRLTE------------MLCQKEKE--- 1630
++ D +N ++ + +Q EK++EL L E + QKE E
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415
Query: 1631 -----------PGNSALEERE------QEKFNL-----KEELERCKVQSSTL-------V 1661
N LE+ + Q+K L KEE+E K++ +
Sbjct: 2416 DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA 2475
Query: 1662 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL--------HRCPDLSD---------- 1703
E E+S K ++ LL++ L + +Q H P S+
Sbjct: 2476 KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSG 2535
Query: 1704 ----------------FQQKISSVLSYNEKLLKEK-------EALSEELNSCVDKLAKSS 1740
+++IS + NE+L+K+K + LS E+ + ++ K
Sbjct: 2536 IVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595
Query: 1741 LLEHRIATMKQEQKSWE-HQSASLKSQLVASQEKVQNLEDTVQNVNLQM----SRMKSDL 1795
H+ T + KS + +AS K Q+ SQ K +NL+D V + + SR KS
Sbjct: 2596 --AHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKS-- 2651
Query: 1796 RVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
+ + L ++QNAG +S
Sbjct: 2652 LPSPHPVRYFDNSSLGLCPEVQNAGAES 2679
Score = 139 bits (350), Expect = 3e-32
Identities = 295/1382 (21%), Positives = 578/1382 (41%), Gaps = 222/1382 (16%)
Query: 840 QSLEGRYRQELKDLQEQQRE---EKSQWEFEKDELTQECAEAQELLK-ETLKREKTTSLV 895
++L RYR+E+ DL++Q E E EKD+L Q E L K + K E T ++
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
Query: 896 LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE-- 953
+T L++ K V L + ++N + Q + I +HK
Sbjct: 402 VTSSSLTLQQELKAKRKRRVT---WCLGKINKMKNSNYADQFNIPTNI--TTKTHKLSIN 456
Query: 954 -LREREEVLCQAGASEQLASQRLERL-EMEHDQERQEMMSKLLAMENIH------KATCE 1005
LRE +E +C + + S L+ L E+E + +KLL ENI +A +
Sbjct: 457 LLREIDESVC---SESDVFSNTLDTLSEIEWNP-----ATKLLNQENIESELNSLRADYD 508
Query: 1006 TADRERAEMSTEISRLQSKIKEMQ-----QATSPLSMLQSGCQVIGE----------EEV 1050
+ ++ TE ++ K+KE +A + Q+I E EV
Sbjct: 509 NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEV 568
Query: 1051 EGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS--------RLQQRL- 1101
+ L +LL E D + LQ + EN+KM S +++Q L
Sbjct: 569 YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLF 628
Query: 1102 --------QKLEPGLVMSSCLD-EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSD 1152
K E + S L+ + + T +Q E +Q ++ Q+E + V D
Sbjct: 629 DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS-QLEAKKKMQV--D 685
Query: 1153 LEDD------EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1206
LE + E+ L S V + + E E + + N E E+ L+ ++
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA--LREEV 743
Query: 1207 SQLQEQLMMLCADCDRASEKKQDLLFDVSVL-KKKLKMLERIPEASPKYKLLYEDVSREN 1265
L E L L ++ +R ++ QD ++ ++ +K K+ + + + L E++ +
Sbjct: 744 ILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802
Query: 1266 DCLQ----------------EELRM-METRYDEALENNKELTAEVFRLQDELKKMEEVTE 1308
D L + L M E +Y LE N+ + E+ L E +K +
Sbjct: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS--- 859
Query: 1309 TFLSLEKSYDEVKIENEELNVLVLRLQ---GKIEKLQESVVQRCDCCLWEASLENLEIEP 1365
SL E+ + +EL +Q ++E+L+E + R +++L+ +E E
Sbjct: 860 ---SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR------DSTLQTVEREK 910
Query: 1366 DGNILQLNQTLEECVPRVRSVHHVIEECKQ-------------------ENQYLEGNTQL 1406
+L QTLEE V+++ ++ KQ N ++ QL
Sbjct: 911 TLITEKLQQTLEE----VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL 966
Query: 1407 ---LEKVKAHEIAWLHGTIQTHQER--PRVQNQVILEENTTLLGFQDKHFQHQ--ATIAE 1459
LE +K H+ TI T + + V + +EENT G FQ + +
Sbjct: 967 RNALESLKQHQ-----ETINTLKSKISEEVSRNLHMEENT---GETKDEFQQKMVGIDKK 1018
Query: 1460 LELEKTKLQELTRKLKE--------RVTILVKQKDVLSH------GEKEEELKAMMHDLQ 1505
+LE Q LT +K+ ++ L+++K+ L EKE+ + +++
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078
Query: 1506 ITCSEMQQKVELLRYESEK-----LQQENSILRNEITTLNEEDSISNL--KLGTLNGSQE 1558
+T E Q+++ LL E +K Q++N ++ E D ++ + KL + +
Sbjct: 1079 MTI-ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137
Query: 1559 EMWQKTETVKQENAAVQKM---VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQE 1615
E Q+ V++E + +QK +ENLK ++ ++ + ++ E EL+QK ++N E+++
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197
Query: 1616 LNQ-----RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV---QSSTLVSSLEAE 1667
+ + + + + E++ + E E KEEL+ + + + L
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS 1257
Query: 1668 LSEVK---IQTHIVQQENHLLKDEL----EKMKQLHRCPDLSDFQQKISSVLSYNEKLLK 1720
+SE I T +++ + L++E+ E+ + L ++S+ Q+ ++ + +LL
Sbjct: 1258 VSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL-----ELLT 1312
Query: 1721 EKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDT 1780
E+ + ++ + L E + ++E KS + +LK+ A + K L++
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNE-KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371
Query: 1781 VQN--VNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEI-----ATHPS 1833
++ +Q S+ K + + +EK+ +++S +Q + EI +
Sbjct: 1372 IRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ 1431
Query: 1834 GLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1893
H++ K ++ +K D + Q++L E+++L+ ++ A+ + E+++ L K
Sbjct: 1432 ESHDEMKSVAKEKDD--LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL--K 1487
Query: 1894 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK 1953
Q+ +N +E+E E QK+ N K L+ +++ I+ + E
Sbjct: 1488 EQEETINELRVNLSEKE-----TEISTIQKQLEAINDK------LQNKIQEIYEKEEQFN 1536
Query: 1954 KKQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2012
KQ+ ++ E++ E++ + S LQ ++ + + R Q Q + Q++ E+
Sbjct: 1537 IKQISEVQEKVNELKQFKEHRKAKDSA----LQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 2013 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVK-RLLQEK---VNQLK 2068
+ ++ E E + + N +++V M+E + Q LK+ QEK + LK
Sbjct: 1593 --EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLK 1650
Query: 2069 EQ 2070
EQ
Sbjct: 1651 EQ 1652
Score = 134 bits (337), Expect = 9e-31
Identities = 298/1488 (20%), Positives = 615/1488 (41%), Gaps = 207/1488 (13%)
Query: 270 LKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQ 329
LK H ++ DE R + +A ++ + D H ++ + EE Q
Sbjct: 1244 LKEH--QETIDELRRSVSEKTA-------QIINTQDLEKSHTKLQEEIPVLHEE-----Q 1289
Query: 330 EILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 389
E+L + + + EL L E TK+S LA + E L E+ + E
Sbjct: 1290 ELLPNVKEVSETQETMNELELLTEQS--TTKDS---TTLARIEMERLRLNEKFQESQEEI 1344
Query: 390 EKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQ 449
+ L + D + +K + + D +L E +E +A ++ K+ +
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHD---------------QLKEHIRETLAKIQESQSKQEQS 1389
Query: 450 I-LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 508
+ +++ + ++ E+E+ K +++ + R+ + + S+ E + + +A+ ++
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALL-RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ 1448
Query: 509 KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR---NEYERQCRVLQDQVDELQSELE 565
+LQ L++ + ++ A+ EE L E E L+ + E ++E+
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508
Query: 566 EYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 625
+ Q + L+N E E E+ N +S E V E + + H
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKE------------EQFNIKQISEVQEKVNELKQFKEH 1556
Query: 626 RDICCLRLE-LEDKVRHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNE 681
R L+ +E K+ +L E+ + K +E MK+ E L+ + LK
Sbjct: 1557 RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE----ALQIERDQLKEN 1612
Query: 682 IAELQGQAAVLKEAHHE---ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 738
E+ + +E ++ T +E ++K +++ +E+ Q KL L++ RLT
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLT 1671
Query: 739 QA-------QASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELR 791
Q S +ER+ L+S EE ++ +L++ +E +T +EK +EEL+
Sbjct: 1672 QILHENLEEMRSVTKERDDLRS---VEETLKVERDQLKENLRETITRDLEK----QEELK 1724
Query: 792 KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELK 851
++ H +E QE +K+ + +T++I S+ QK E AL++ + + ++EL+
Sbjct: 1725 --IVHMHLKEHQETIDKLRGIVSEKTNEI-----SNMQKDLEHSNDALKAQDLKIQEELR 1777
Query: 852 ----DLQEQQR----------EEKSQWEFEKDELTQECAEAQELLKE---------TLKR 888
L+EQQ E+ + + +L A+ QE ++E TLK+
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837
Query: 889 EKTTSLVLTQEREMLEKTYKEH---LNSMVVER----QQLLQDLEDLRNVSETQQSLLSD 941
+ + E E L+K K+ L+ + +E Q+L ++LE++++V + + D
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER-----D 1892
Query: 942 QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM---EH----DQERQEMMSKLL 994
+ ++ + K E + +E L + A + Q L+ M EH D+ R+++ K +
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952
Query: 995 AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML------------QSGC 1042
+ +I K D+ + E+ +I LQ K ++ + ++M Q
Sbjct: 1953 QISDIQK----DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008
Query: 1043 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQR 1100
Q + + V D L ++ + LEE +++ +R + +KE++KM + I+ L++
Sbjct: 2009 QNLSMQSVRMDN-FQLTKKLHESLEEIR--IVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 1101 LQK------LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE 1154
+ + ++P + S + TE + + L++ + DLE
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125
Query: 1155 DD-------EVRDLGSTGTSSVQRQEVK---IEESEASVEGFSELENSEETRTESWELKN 1204
+ +R + +Q + ++ S+E ++ + + ++K
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Query: 1205 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIP---EASPKYKLLYEDV 1261
+ + + M D EK+++LL + L++ + R + + L E++
Sbjct: 2186 EQHESINKFEMDFID---EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242
Query: 1262 SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1321
+ D + E ++T + + L N KE+T L++ L ++ + ++K D +
Sbjct: 2243 LK--DFSESEFPSIKTEFQQVLSNRKEMTQF---LEEWLNTRFDIEKLKNGIQKENDRIC 2297
Query: 1322 IENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVP 1381
N N ++ + + + +E WE L++L+ E + + + QTL+ +
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISK--EWEQDLKSLK-EKNEKLFKNYQTLKTSLA 2354
Query: 1382 RVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQT--HQERPRVQNQVILEE 1439
V+ ++ K + EK++ E + LH ++ H+E ++ Q LE
Sbjct: 2355 SGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENS-LHEAKESAMHKESKIIKMQKELEV 2413
Query: 1440 NTTLLGFQDKHFQHQATIAELE--LEKTK--LQELTRKL-------KERVTILVKQKDVL 1488
++ + QA + E LEKTK +Q L K+ KE + L K K V
Sbjct: 2414 TNDIIA------KLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL-KMKLVK 2466
Query: 1489 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1548
EK + K ++ T + ++ + E++R E L++ + + + + SN
Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526
Query: 1549 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1608
L GS K +K E+ L+K+IS+LK +N+QL + EL N
Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEHI-------RLEKEISKLKQQNEQLIKQKNELLSNNQH 2579
Query: 1609 NQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL--ERCK 1654
+++ +R + K+ NS + + K+++ +CK
Sbjct: 2580 LSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCK 2627
Score = 90.9 bits (224), Expect = 1e-17
Identities = 148/717 (20%), Positives = 296/717 (41%), Gaps = 107/717 (14%)
Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
+LEE L Q++ ++ + T QEL K K RVT + + + + + +
Sbjct: 379 LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD 438
Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-------------- 1541
+ + IT + + LLR E + E+ + N + TL+E
Sbjct: 439 QFNIPTN---ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQEN 495
Query: 1542 -EDSISNLKLG---------TLNGSQEEMWQKTE--------------TVKQENAAVQKM 1577
E +++L+ L +EEM K + T K + +
Sbjct: 496 IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHE 555
Query: 1578 VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE 1637
+ NLK + ++ NQ DLEN ELS K +EK ++ ++L E + + LE
Sbjct: 556 ISNLKNLVKHAEVYNQ--DLEN-ELSSKVELLREKEDQI-KKLQEYI-------DSQKLE 604
Query: 1638 EREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM----K 1693
+ + E +E K TL + E + K ++ ++ EN LK++++++ K
Sbjct: 605 NIKMDLSYSLESIEDPKQMKQTLFDA-ETVALDAKRESAFLRSENLELKEKMKELATTYK 663
Query: 1694 QLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEE---LNSCVD-KLAKSSL----LEHR 1745
Q+ D+ +Q ++ + L KE ++ E L S +D K+ K L LE +
Sbjct: 664 QMEN--DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 721
Query: 1746 IATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL 1805
I +++E ++ +L+ +++ E +++L V+ + ++ +L + EK+ L
Sbjct: 722 ITDLQKELNKEVEENEALREEVILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKL 780
Query: 1806 KQEVMSLHKQLQNAG-----GKSWAPEIATHPSGLHNQQKRLSWDKLDHL-MNEEQQLLW 1859
EV +HK+ + G GK+ ++AT S + + K H+ ++ +++
Sbjct: 781 FSEV--VHKESRVQGLLEEIGKT-KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837
Query: 1860 QENERLQTMVQN--------------TKAELTHS----REKVRQLESNLLPKHQ---KHL 1898
+ENER+ + N K EL++ +EK R+++ L Q +
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Query: 1899 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1958
N T+ E+EK + + Q +E + + L+Q E++ +E + LK
Sbjct: 898 NRDSTLQTVEREKTLITEKLQQTLEE---VKTLTQEKDDLKQLQESLQIERDQLKSDIHD 954
Query: 1959 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ----RQLLQAERIN 2014
++ Q A S H + L+ + V R ++ + Q + +
Sbjct: 955 TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG 1014
Query: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
+++LE + ++T T +++ + +++K +L + L E V KEQ+
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQML--ESVIAEKEQL 1069
Score = 56.2 bits (134), Expect = 3e-07
Identities = 101/532 (18%), Positives = 207/532 (38%), Gaps = 60/532 (11%)
Query: 1550 LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQN 1609
L L + + K E + + +++ +K+I +LK + +++ LE + + Q
Sbjct: 317 LTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL 376
Query: 1610 QEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELS 1669
+ L+E L++ + EK E L R V SS+L E +
Sbjct: 377 AQLLEE-----------------KDLLQKVQNEKI---ENLTRMLVTSSSLTLQQELKAK 416
Query: 1670 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL 1729
+ T + + N + + + I+ + +E + E + S L
Sbjct: 417 RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTL 476
Query: 1730 NSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS 1789
++ S +E AT Q++ E + SL++ + L + + L++
Sbjct: 477 DTL-------SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL- 528
Query: 1790 RMKSDL-RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1848
+ K+DL E++ K + M L ++ N K+ + L N+ K++
Sbjct: 529 KEKNDLDEFEALERKTKKDQEMQLIHEISNL--KNLVKHAEVYNQDLENELS----SKVE 582
Query: 1849 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTE 1908
L +E Q+ + ++N K +L++S E + PK K T+ E
Sbjct: 583 LLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED------PKQMKQ-----TLFDAE 631
Query: 1909 QEKLSLKRECDQFQKEQSPANRKVSQM----NSLEQELETIHLENEGLKKKQVKLDEQLM 1964
L KRE + E K+ ++ +E +++ + E KK QV L+++L
Sbjct: 632 TVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQ 691
Query: 1965 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE---L 2021
+ + T D ++ + C + + LQ++L + N+ L+EE L
Sbjct: 692 SAFNEITKLT-----SLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746
Query: 2022 ENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL--QEKVNQLKEQV 2071
S + + ++++ EE I +K KL ++ + +V L E++
Sbjct: 747 SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 970 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2443
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2444 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2482
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2483 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2531
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2532 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2557
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685
Query: 1172 QEVK 1175
++V+
Sbjct: 2686 EDVR 2689
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 968 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2271
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2325
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1067 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1124
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1125 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1178
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1239 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1290
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1333
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1334 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1382
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1383 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1443 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1560
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1679
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1738
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1843
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1844 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2080
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2377
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2431
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1406
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1462
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1581
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1881
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 1882 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2120
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2179
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2180 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2224
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2225 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2284 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2334
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2335 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2381
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2382 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2436
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2493
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2604
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2605 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2665 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2713
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 974 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1032
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1092
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1093 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1153 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1389 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1507 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1560
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1857
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1914
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 1975 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2032
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2447
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2448 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2486
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2487 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2535
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2536 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2561
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2604
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 1957 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2070
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2122
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2176
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2177 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2220
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2279
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2338
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2339 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2455 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2495
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2496 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2553
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2554 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2585
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2586 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2634
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2635 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2689
Query: 1172 QEVK 1175
++V+
Sbjct: 2690 EDVR 2693
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 972 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1029
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 1030 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1085
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1146 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1188
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1189 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1358
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1416
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1417 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1467
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1527
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1702
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1819
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1820 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1927
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 1928 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2041
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2218
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2219 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2275
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2276 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2329
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 970 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2443
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2444 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2482
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2483 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2531
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2532 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2557
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685
Query: 1172 QEVK 1175
++V+
Sbjct: 2686 EDVR 2689
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 968 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2271
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2325
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1031 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1088
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1089 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1142
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1203 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1254
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1297
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1298 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1346
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1347 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1407 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1524
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1643
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1702
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1807
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1808 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2044
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2341
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2395
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1370
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1426
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1545
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1845
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 1846 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2084
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2143
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2144 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2188
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2189 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2248 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2298
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2299 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2345
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2346 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2400
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2457
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2568
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2569 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2629 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2677
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 938 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 996
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 997 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1056
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1057 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1117 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1353 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1471 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1524
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1821
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1878
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 1939 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 1996
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2411
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2412 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2450
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2451 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2499
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2500 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2525
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2568
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 1921 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2034
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2086
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2140
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2141 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2184
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2243
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2302
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2303 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2419 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2459
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2460 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2517
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2518 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2549
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2550 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2598
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2599 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2653
Query: 1172 QEVK 1175
++V+
Sbjct: 2654 EDVR 2657
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 936 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 993
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 994 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1049
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1110 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1152
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1153 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1322
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1380
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1381 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1431
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1491
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1666
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1783
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1784 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1891
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 1892 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2005
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2182
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2183 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2239
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2240 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2293
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1200 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1257
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1258 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1311
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1372 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1423
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1466
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1467 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1515
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1516 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1576 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1693
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1812
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1871
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1976
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1977 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2213
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2510
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2564
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1539
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1595
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1714
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 2014
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 2015 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2253
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2312
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2313 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2357
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2358 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2417 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2467
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2468 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2514
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2515 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2569
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2626
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2737
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2738 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2798 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2846
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 1107 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1165
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1225
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1226 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1286 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1522 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1640 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1693
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1990
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 2047
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 2108 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2165
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2580
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2581 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2619
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2620 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2668
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2669 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2694
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2737
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 2090 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2203
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2255
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2309
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2310 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2353
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2412
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2471
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2472 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2588 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2628
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2629 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2686
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2687 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2718
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2719 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2767
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2768 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2822
Query: 1172 QEVK 1175
++V+
Sbjct: 2823 EDVR 2826
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 1105 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1162
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1218
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1279 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1321
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1322 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1491
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1549
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1550 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1600
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1660
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1835
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1952
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1953 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 2060
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 2061 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2174
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2351
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2352 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2408
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2409 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2462
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1041 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1098
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1099 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1152
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1213 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1264
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1307
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1308 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1356
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1357 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1417 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1475
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1476 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1534
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1653
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1712
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1817
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1818 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2054
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2351
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2405
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1380
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1436
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1555
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1855
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 1856 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2094
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2153
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2154 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2198
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2199 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2258 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2308
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2309 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2355
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2356 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2410
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2467
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2578
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2579 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2639 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2687
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 948 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1006
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1066
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1067 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1127 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1363 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1481 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1534
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1831
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1888
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 1949 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2006
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2421
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2422 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2460
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2461 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2509
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2510 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2535
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2578
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 1931 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2044
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2096
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2150
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2151 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2194
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2253
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2312
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2313 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2429 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2469
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2470 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2527
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2528 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2559
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2560 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2608
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2609 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2663
Query: 1172 QEVK 1175
++V+
Sbjct: 2664 EDVR 2667
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 946 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1003
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1059
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1120 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1162
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1163 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1332
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1390
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1391 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1441
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1501
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1676
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1793
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1794 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1901
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 1902 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 1960 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2015
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2192
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2193 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2249
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2250 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2303
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1049 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1106
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1107 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1160
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1221 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1272
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1315
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1316 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1364
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1365 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1425 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1483
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1484 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1542
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1661
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1720
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1825
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1826 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2062
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2359
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2413
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1388
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1444
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1503
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1563
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1863
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 1864 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2102
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2161
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2162 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2206
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2207 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2266 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2316
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2317 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2363
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2364 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2418
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2475
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2586
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2587 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2647 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2695
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 956 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1014
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1074
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1075 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1135 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1371 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1489 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1542
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1839
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1896
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 1957 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2014
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2429
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2430 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2468
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2469 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2517
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2518 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2543
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2586
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 1879 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 1939 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2052
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2104
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2158
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2159 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2202
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2261
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2320
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2321 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2437 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2477
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2478 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2535
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2536 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2567
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2568 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2616
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2617 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2671
Query: 1172 QEVK 1175
++V+
Sbjct: 2672 EDVR 2675
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 954 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1011
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 1012 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1067
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1068 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1128 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1170
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1171 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1340
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1398
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1399 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1449
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1509
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1629
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1684
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1801
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1802 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1909
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 1910 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 1968 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2023
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2200
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2201 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2257
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2258 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2311
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 176 bits (446), Expect = 2e-43
Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)
Query: 352 LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
L +EL +T + Q + S A L+ + V+R +E LR+ ++ ++ +++ A
Sbjct: 1090 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1147
Query: 408 S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
+ E++ A++++ LR E + AL++ELR +E + ++ ++ E + E+
Sbjct: 1148 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1201
Query: 466 EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
E+ + + +R L + + EL + +L Y + L +R E +
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261
Query: 519 AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
A D + E QE+ L + E ER ++V+E Q ++Y + L L
Sbjct: 1262 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1313
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
++ S +P+ GSE VI Q + D+ EL
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1356
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
Y K + ET+ +R E E E+Q ++ + +AE++ + L EA
Sbjct: 1357 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1405
Query: 696 HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
H +A + E E K+LQ +++EE K +QE+L R E E++A+
Sbjct: 1406 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465
Query: 739 QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
QA+A+ ER R ++ TE + G EL+ + +K E E
Sbjct: 1466 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1524
Query: 789 ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
LR+++ ++ QR+ Q R K E E R Q Q + + E E L+ E
Sbjct: 1525 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1583
Query: 844 -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
R RQ L+ QR +++ + ++ ++ A+ + L+E L+ E
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
Query: 897 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
E E + + L ++ + L+ V++ Q+SL + + K +RE R
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1702
Query: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
R + QA +LA Q LE+ + Q+ ++ + + +A E +++R +
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1761
Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
E++RLQ + ++ Q+ + L+ +++ +V+ + + + S ++ +Q LE
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
L + A +A+ E K +++ Q+ E V+ AE+
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1866
Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
+ R K + + + E++ +R L +R E + + +A +E ++
Sbjct: 1867 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924
Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
L + ++ E + Q Q++E+++ L A ++A+ K +L ++ ++
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984
Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
L+ E+ + + + L + R +E ++ +EA K EV RL+
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
+E +++ E E L L + + +++ EE +Q K ++LQ+++ Q
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2103
Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
D EA E ++ + Q L Q+ EE E
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
+ ++E + E+ + ++ H++ ++ + +E+ T L Q +
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223
Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
HQ + + EL++ K + E KLK R+ +++
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
+ KD E+ E++K + + L + E QQ+ + EK+
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
Q QE + L+ E L ++ ++ + L +E+M Q+ + +E Q+ +E ++
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2400
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ E+ + ++L L E+S+ ++ +E Q ++ E+ + + E QEK
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2454
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
L + LE + QS L ++E++ + +QQE LL+ + E+M+ + + L +
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
Q S LS + LL+ + + +E K L + +A +++EQ+ + Q
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568
Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+ +LVAS E+ + + + + V + ++ + +Q++E L +E L +QLQ
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Score = 174 bits (440), Expect = 1e-42
Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)
Query: 384 QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
Q+V K +L A+K K SE R + L L +Y + I+ +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371
Query: 444 RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
+E QQ ++R LE ++++ +A + +R A L++ R++ E++
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1429
Query: 495 ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
E + + +Q L+ + ++ + Q E + R E + RV++
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1485
Query: 555 DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
Q++ + EL+ RA+ K EE E ++ E + L
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
++AE + K++ + + LRL+ E+ R + + + V+ + AQ + +
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1604
Query: 664 HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + ++ + L+ + E A L+E A A + E E+ + + + E E+ L+
Sbjct: 1605 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664
Query: 723 E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
+LRLQ E+ + L QA+A ++E RE + E+ VR QELE+
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724
Query: 772 HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
Q + ++ E+E +R ++LLE+ LQ + R+++E E
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784
Query: 814 NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
+ +++E A+ + + + +E+ + L++ GR+R+ E L+ E K Q
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
Query: 865 EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
+ +++ ++ AEA+ +L E L R KT + + +E+E + + +R
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1904
Query: 919 QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
++L + D+E+ LR S E Q+ L+ D +IL LK+S ++
Sbjct: 1905 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964
Query: 954 LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
+ E+ + G A L E+ E+E ++RQ E + A E + K+
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024
Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
E A R+R E+ RL++K++E Q++ L + Q Q + EE+
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084
Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
Q+ +Q L++ VL L+ RA E+A + V+ E ++ ++++++ E
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2143
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
L S+ A AE+ +Q R + + R+ +D E ++ +
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2202
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
RQ+ ++E+ ++ R + E +Q + L E+L L A+ A+
Sbjct: 2203 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2247
Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
++ + LF V V ++L L+ EA + L+ D LQEE M+ +E
Sbjct: 2248 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
A A + E ++ ++ E L+ +++ E K+ E++ + RL+ + E
Sbjct: 2307 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2357
Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
LQ+ L + L+ + + Q+ Q L E + +E +Q
Sbjct: 2358 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2404
Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
+ + L K++ E++ + +R R Q + I E+ + T L Q+K +
Sbjct: 2405 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2459
Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
LE+++ + +L+E + L ++K+ L K +LK+ ++Q T + Q E
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2516
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
+ L +++S+L+ E E+ + L ++ +EE ++ + ++QE +
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
+E +++ E + ++ E +L Q+ Q +E L E NQRL E L
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2627
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
LEE+ + EE+ +V ++ + +L+ +E K+ +Q+
Sbjct: 2628 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687
Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
L +EL+++ Q H R D+ + Q SS+ K EK
Sbjct: 2688 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2736
Score = 172 bits (437), Expect = 2e-42
Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)
Query: 537 ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
+ L Q E R R + + D LQ E E R R LRLPL P+ E
Sbjct: 997 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1055
Query: 586 ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
VE G+ E E L E +P ++ +EL + K + R + + LE
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1115
Query: 635 ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
E+ +R +E+QL E + + K + + ++ + E + T +
Sbjct: 1116 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175
Query: 674 QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
L++E+ Q L++ H E E ++++ LE + L + Q E+E
Sbjct: 1176 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 733 LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
L +L + S + LQ + +E+++ + +Q + EQ QEQ L +E+H +
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291
Query: 787 KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
EE ++ ++ ++ +L + ++E + + ++++ +S Q+ + S
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
L +L +Y + + + + EE+ E ++ E + AE + L++ + + +
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411
Query: 898 Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
Q ERE K ++ + VV R++ D E+L+ + ++ ++ + + + ++
Sbjct: 1412 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469
Query: 949 SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
+ + LR EE V Q A+E+ L+ + + K A E + +
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
D + + E+ L S++K +A Q Q + E ++ + A L+Q E
Sbjct: 1530 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1583
Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
+E V ++L+ A A E K A+ + Q + L+ V + L E A
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
AE + E L++ + K Q E V ++ L+ E + E R
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
G +V+++E+ ++E+ EG ++ + E R E+ + + Q L+E+L
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763
Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
L + A++K+Q+L +++ ++ ++++L +R+ + ++
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ L E+ +R +E R + ++A E L ++L + E T E
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1880
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
+ E + ENE L L + +L+E Q + D E L L D + +
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1937
Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
+E+ + + R V I K + G +L L +++++ L Q E
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997
Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
R Q Q+ EE +L ++ Q +A + E+E K K++E R+L+ER
Sbjct: 1998 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2055
Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
+ + Q+ + EE+ A +LQ T + Q ++ LR E+E ++
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E + S ++ E + Q E Q A Q E L+K+ +
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
+ Q + Q EK ++ ++ Q E+E L EE + +K
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
L EEL+R K +++ S +E EL V++Q ++ EN
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
L++E EKMKQ+ LS Q+ + + E+ L ++ AL+E++
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
A++ LL+ + +++ + + + QL + Q + + L+MS R
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
+K + + + +++ KQ + G K E+AT Q + + DH
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2470
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ERL+ + AEL +EK++Q E+ LL + M +QE
Sbjct: 2471 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2509
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
+L Q+ Q+ +S+ +SL Q I E E K +Q+ DE + + Q LR
Sbjct: 2510 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2558
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
+ QRQ Q E+ Q L +E E
Sbjct: 2559 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2584
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
Q E+ V +E + ++EQ+ + + LL E+ +L+EQ+ L
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2627
Score = 123 bits (308), Expect = 2e-27
Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)
Query: 326 ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
E ++ KA D L+ L E TL +E E+L K S +AA A + E+ +
Sbjct: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979
Query: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
+ +R KE+ ++L+ A + + +A+E + E R + +L +E ++R AAL
Sbjct: 1980 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 440 KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ E R+ RE Q+ Q+A ++RL+ E++ ++ L
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2093
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+L++ + ++L AE + + E A+ ++ + ERL
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2145
Query: 541 QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
Q E + Q ++L+ E E+ RAQ L K + E+E +
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2199
Query: 598 GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
AE + Q K Q +++ LRL+LE+ H + LDE + K +A
Sbjct: 2200 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2243
Query: 657 QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
E +QR + E +++S LK I E + +A +L++ + EE +K Q
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2302
Query: 712 VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
V E + + QE RL+ E +L + A+ + + + +Q + + + L Q+
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2361
Query: 768 LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
++ QEQ L E +KE++ ++L E+ QR L+ R++ M E R
Sbjct: 2362 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 816 RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
S+ +A+ + D Q+ ++ E + L QE L + ++ Q + + + L +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
AE L+REK L QE ++L+ +E V+++QLLQ+ + L
Sbjct: 2478 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2518
Query: 934 TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
QQS LS D +L+ + ++E + E++ A Q + +R + + +QERQ ++
Sbjct: 2519 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2576
Query: 992 KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
A+ E A R + E + R Q ++++++Q
Sbjct: 2577 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2608
Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
QQ E L EEN + LQ EQ + + + E++ Q K P
Sbjct: 2609 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2657
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
LD PA E AE F R + + +LS E + +T +R
Sbjct: 2658 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2712
Query: 1172 QEVK 1175
++V+
Sbjct: 2713 EDVR 2716
Score = 111 bits (278), Expect = 6e-24
Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
L Q LEQ QE+ S ++ E +++R +L R + R ++ E R +Q A+
Sbjct: 995 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1052
Query: 824 FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
Q +V + + S E L + +S+ E +L Q + L
Sbjct: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1108
Query: 883 KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
L++ KT SLV+ TQ E + + ++E L + + E + L+ LR +E
Sbjct: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168
Query: 935 QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
QQ + + ELR +EV E+L + ER +E+E +ER +
Sbjct: 1169 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1211
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
+E +T R+R E+ +L +++ +++ PL + LQ Q+
Sbjct: 1212 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
+ L+Q + LLEE +G+ + QR +Q A+K+ +++ T ++L+
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
+ V S + L +F T + E ++ R + +
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1381
Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
R L+++E ++ R L + + E + +E + ++ E+ EE ++
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1439
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
+ K I + +QL ++ + ++ +Q + S L RI E +L E
Sbjct: 1440 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1490
Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
R+ + EL+ + R +EA ++ E RL QDE ++ + S K+
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1550
Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
E E + L L L+ + +L+++ V+R
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610
Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
A LE E + QL + E + EE ++E + L+ N L
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1670
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
+++A E+A Q E+ + + E G ++ Q +AE ELEK +
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1725
Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
Q ++R+ L++ + GE++ +L + + LQ + QK + L E
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
K++ E +L EE ++ K ++ +++ + +E A ++ + E K+
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1842
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
Q ++ + + E + ++ + E + TE + KEKE N L ++
Sbjct: 1843 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
+ + LE Q + A+L K ++++ L++D L + +Q+
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1950
Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
+++I ++ + EK K L EL ++ D L E A +Q E++
Sbjct: 1951 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2008
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
++ L A +E + + ++ V R+K+ + ++ +E +QE +
Sbjct: 2009 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2064
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
Q A K E H + +++ L LD L E E+
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
+ E E Q+ Q +AE L S E+ Q + +K + EQ L
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
K+ D + +K + A + + Q +EQEL T+ L+ E ++ LDE E+Q L++
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2241
Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
AT + + Q+ ++ V E+ +L+ R L+ ++ N + LQEE E
Sbjct: 2242 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2298
Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+ + +L + EE ++ Q+ L +++L+EK+ ++E L
Sbjct: 2299 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2352
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 170 bits (431), Expect = 1e-41
Identities = 342/1676 (20%), Positives = 710/1676 (42%), Gaps = 232/1676 (13%)
Query: 400 EKLKSLMASEVDDHHAAIERRNEYNLRKLDE----------EYKERIAALKNELRKEREQ 449
++LK + E+DDH + + +KL E +Y+ERI L+N L++
Sbjct: 219 KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278
Query: 450 ILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNK 509
+++ + E+++ I+ + E+ S K+ +LE+++ + +KL+ EN +
Sbjct: 279 VIETDLSKIYEMQKTIQVLQIEK-------VESTKKMEQLEDKIKDINKKLSSAENDRDI 331
Query: 510 LQRNLENVLAEK-------------FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ 556
L+R E + EK L PS+ + Q + +T+ + V ++
Sbjct: 332 LRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK---QSDTMTEKERILAQSASV--EE 386
Query: 557 VDELQSELEEYRAQGRVLRLPLKNSPSEEVEAN------SGGIEPEHGLGSEECNPLNMS 610
V LQ L + A+ ++RL N + E N +E E L S+E L MS
Sbjct: 387 VFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMS 444
Query: 611 -IEAELVIEQMKEQHHRDICC------LRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 663
++ E +K RDI LRL LE K + + + E + +E +Q
Sbjct: 445 LLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQN 504
Query: 664 HENETH--TLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHL 721
E H ++ Q+S +NE G + + K +EKK++ +LE++K +
Sbjct: 505 QEATKHMILIKDQLSKQQNE-----GDSIISKLKQD-----LNDEKKRVH-QLEDDKMDI 553
Query: 722 QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE 781
++L +Q E +++ + +++ E+KV L +L + + ++ ++
Sbjct: 554 TKELDVQKEKLIQSEVALNDLHLTKQK--------LEDKVENLVDQLNKSQESNVS--IQ 603
Query: 782 KHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQS 841
K LE KE + +++ EL R ++ N+ ++ + F+ K ER E+ +++
Sbjct: 604 KENLE----LKEHIRQNEEELSRIRNELMQSLNQDSN---SNFKDTLLK--ER-EAEVRN 653
Query: 842 LEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL------- 894
L+ + EL+ L E ++ + E ++L C + + L+E L SL
Sbjct: 654 LK-QNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVE 712
Query: 895 VLTQEREMLEKTY---KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHK 951
L E+ +E K+ L + ++ +++L + RN++ + L + +++L
Sbjct: 713 TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 772
Query: 952 REL--------------REREEVLCQAGASEQLASQRLERLEMEHD---------QERQE 988
E+ +E ++VL + ++ +Q + + E+ + QE +
Sbjct: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832
Query: 989 MMSKLLAMENIHKATCETADRERAEMSTEISRLQ---SKIKEMQQATSPLS---MLQSGC 1042
S+ L I + T E DR M E + LQ +++E Q T+P++ L S
Sbjct: 833 KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT 892
Query: 1043 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQ 1102
++ E +S L ++ LEE + H Q + E+ + Q ++Q
Sbjct: 893 ELASE--------VSQLNTIKEHLEE--------EIKHHQKIIED--------QNQSKMQ 928
Query: 1103 KLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLG 1162
L+ +DE + A T+ FL+++ + T + + L +E +D+
Sbjct: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH-EERQDIQ 987
Query: 1163 STGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW-----ELKNQISQLQEQLMMLC 1217
+ + Q +V+ ++E SE + + TE E + +I L E+ + L
Sbjct: 988 TDNSDIFQETKVQ----SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLT 1043
Query: 1218 ADCDRASEKKQDLLFDVSVLKKKLK---MLERIPEASPKYKLLYEDVSRENDCLQEELRM 1274
D+ S+ + L + + +K L+ + RI S ++Y LQ++L+
Sbjct: 1044 KQIDQLSKDEVGKLTQI-IQQKDLEIQALHARISSTSHTQDVVY---------LQQQLQA 1093
Query: 1275 METRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
++ E T E L+ E KM ++ + E + +++ EN++L+ R
Sbjct: 1094 YAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV---AAKEAALIKLQDENKKLST---RF 1147
Query: 1335 QGKIEKLQESVVQRCDCCLWEASLE----NLEIEPDGNILQLNQTLEECVPRVRSVHHVI 1390
+ + + +Q + E +E + + + +LQ + T E V S +
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE-AGGVNS--NQF 1204
Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWL----HGTIQTHQERPRVQNQVILE-ENTTLL- 1444
EE QE L+ + +E+ K + + H + Q +E ++Q QV+++ +N + L
Sbjct: 1205 EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQ 1264
Query: 1445 ----GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500
G + Q++ + E ++Q +L +L+ + D++S + ++
Sbjct: 1265 VDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS---PQLSSASL 1321
Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNE-------ITTLNEED-SISNLKLGT 1552
+ C K E+L SE LQQE LR I TL E + +S+ T
Sbjct: 1322 LTPQSAECLR-ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT 1380
Query: 1553 LNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1612
++E Q +KQ + + LK++ +K K+ QL N + K ++N E
Sbjct: 1381 SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNEN-EL 1439
Query: 1613 LQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVK 1672
L++ L E + E + G E + + +E E +Q + + S+ L E +
Sbjct: 1440 LRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM--MLREKE 1497
Query: 1673 IQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSC 1732
+ H + +E L ++L K K+ + +L+ Q +++V S EK + ++ + + +
Sbjct: 1498 FECHSM-KEKALAFEQLLKEKEQGKTGELN---QLLNAVKSMQEKTVVFQQERDQVMLAL 1553
Query: 1733 VDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK 1792
K +++ L++ + ++ ++ + L++ L+ S ED+ L +
Sbjct: 1554 KQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLES-------EDSYTREALAAEDRE 1606
Query: 1793 SDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1852
+ LR ++ L+++++S ++NA ++ + ++ + L+ K+ L ++
Sbjct: 1607 AKLR---KKVTVLEEKLVSSSNAMENASHQA-SVQVESLQEQLNVVSKQRDETALQLSVS 1662
Query: 1853 EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP--TEQE 1910
+EQ ++ + N + L H +++ + + S L K QK L N E +
Sbjct: 1663 QEQV------KQYALSLANLQMVLEHFQQEEKAMYSAELEK-QKQLIAEWKKNAENLEGK 1715
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM 1966
+SL+ D+ A+R Q++ E+++E + +NE ++ + ++LM +
Sbjct: 1716 VISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSL 1771
Score = 158 bits (399), Expect = 6e-38
Identities = 361/1779 (20%), Positives = 710/1779 (39%), Gaps = 295/1779 (16%)
Query: 436 IAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLE 495
+A+L ++ + +L + + E+E E+ ++T+E I A+ EN RL+ +
Sbjct: 23 LASLTGQISNFTKDMLMEGTE---EVEAELPDSRTKE--IEAIHAILRSENERLKKLCTD 77
Query: 496 NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQD 555
EK E + + N L +K ++ A RQ LQD
Sbjct: 78 LEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKA-----------------RQI-ALQD 119
Query: 556 QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAEL 615
Q+ +LQS + + V P + S + + GI ++ I ++
Sbjct: 120 QLLKLQSAAQSVPSGAGV---PATTASS----SFAYGISHHPSAFHDDDMDFGDIISSQQ 172
Query: 616 VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQI 675
I ++ + R LE +V H+ + KAQ ++E L+ I
Sbjct: 173 EINRLSNEVSR--------LESEVGHWRH-----IAQTSKAQ-GTDNSDQSEICKLQNII 218
Query: 676 SDLKN----EIAELQGQAAVLKEAHH----EATCRHEEEKKQLQVKLEEEKTHLQEKLRL 727
+LK EI + Q + +VL+ AH E + RH EE + ++EE + LQ+
Sbjct: 219 KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278
Query: 728 QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 787
E +L + + E ++S+ +K+ L +++ +++ ++ ++ L +
Sbjct: 279 VIETDLSKIYEMQKTIQVLQIEKVEST----KKMEQLEDKIKDINKKLSSAENDRDILRR 334
Query: 788 EELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYR 847
E+ E L +R++ E E ++ EC++ Q A QSD ER + S+E +R
Sbjct: 335 EQ---EQLNVEKRQIMEECENLKLECSKL--QPSAVKQSDTMTEKERILAQSASVEEVFR 389
Query: 848 --QELKDLQ--------------------------EQQREEKSQWEFEKDELTQECAEAQ 879
Q L D + E +EKS EK+EL +
Sbjct: 390 LQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLN 449
Query: 880 ---ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQ 936
E++K T R+ + L R LE +E LN + E++ L+ ++E+L + Q
Sbjct: 450 NEYEVIKSTATRDISLDSELHDLRLNLEAKEQE-LNQSISEKETLIAEIEEL----DRQN 504
Query: 937 SLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE-------MEHDQERQEM 989
+ ++ +K ++ E + ++ + +R+ +LE E D +++++
Sbjct: 505 QEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKL 564
Query: 990 MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM--LQSGCQVIGE 1047
+ +A+ ++H + ++ ++ L ++ + Q++ + L+ +
Sbjct: 565 IQSEVALNDLHLT--------KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616
Query: 1048 EEVEGDGALSLLQQGEQLLEEN-GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP 1106
EE L+Q Q N D LL + A + +K+N+ +E+ +L + L+K+
Sbjct: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNL---SELEQLNENLKKVAF 673
Query: 1107 GLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGT 1166
+ M + E + Q E L N +E T L + G
Sbjct: 674 DVKMEN---EKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLK-------MEKGEIEA 723
Query: 1167 SSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQ------------ISQLQEQLM 1214
++ +EE+ + EL N+ T + +L+++ I++L++ +
Sbjct: 724 ELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIE 783
Query: 1215 MLCADCDRASEKKQDLLFD----VSVLKKKLKMLERIPEASPKYKL---LYEDVSRENDC 1267
+ D + L + ++ KK +E++ E S K + Y R+N+
Sbjct: 784 QMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI 843
Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1327
L++ + + E N L E+ RL++E + V + S E+ E +L
Sbjct: 844 LRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADP--KTLDSVTELASEVSQL 901
Query: 1328 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
N + L+ +I+ Q+ + + + + +QL Q+L+E +
Sbjct: 902 NTIKEHLEEEIKHHQKIIEDQ-----------------NQSKMQLLQSLQEQKKEMDEFR 944
Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI-----QTHQERPRVQ---NQVILEE 1439
+ Q Q +TQL + K EI L TI Q H+ER +Q + + E
Sbjct: 945 Y------QHEQMNATHTQLFLE-KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQET 997
Query: 1440 NTTLLGFQDKHFQHQATIAELE--LEKTKLQELTRKL-KERVTILVKQKDVLSHGE---- 1492
L ++ +H + AE E ++ K +EL KL E+ L KQ D LS E
Sbjct: 998 KVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKL 1057
Query: 1493 ----KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1548
++++L+ +I+ + Q V L+ + + E R ++ + E + N
Sbjct: 1058 TQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME----REKVFAVLNEKTRENS 1113
Query: 1549 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE-LSQKNS 1607
L T E + + V + AA+ K+ + KK + + Q + E + LS+
Sbjct: 1114 HLKT------EYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167
Query: 1608 QNQEKLQELNQRLTEMLCQKE-KEPGNSA-------LEEREQEKFNLKEE---LERCKVQ 1656
+ ++ L+Q+ +L + GN A EE QE+ LK++ +E K Q
Sbjct: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQ 1227
Query: 1657 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-------QLHRCPD--LSDFQQK 1707
T V +++ E ++++ + H +Q + + D K++ Q + + L +F Q+
Sbjct: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS--WEHQSASLKS 1765
++ V +L K+ L +L+ +L+ +SLL + A + KS S L+
Sbjct: 1288 LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347
Query: 1766 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA 1825
+L ++ +Q + T++ + R+ + T + + ++ S KQL+
Sbjct: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK-------- 1399
Query: 1826 PEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ--ENERLQTMVQNTK---------- 1873
E L ++ L K D L++ + + ENE L+ V N K
Sbjct: 1400 -EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDI 1458
Query: 1874 AELTHSREKV----RQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ-----KE 1924
+L EK+ R E+ + ++ S + E E S+K + F+ KE
Sbjct: 1459 GKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKE 1518
Query: 1925 QSPA---NRKVSQMNSLEQELETIHLENE----GLKKKQVKLDEQLMEMQHLRSTATPSP 1977
Q N+ ++ + S++++ E + LK+KQ++ E+Q LR
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD------ 1572
Query: 1978 SPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQ 2037
++F Q + ER+ HL E ++ T E + + +
Sbjct: 1573 --------------------KEFRSNQ----ELERLRNHLLESEDSYTREALAAEDREAK 1608
Query: 2038 L---VTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
L VTV+EE+++ ++ +V L+EQ+++
Sbjct: 1609 LRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNV 1647
Score = 151 bits (381), Expect = 7e-36
Identities = 306/1504 (20%), Positives = 634/1504 (42%), Gaps = 208/1504 (13%)
Query: 365 QAALASFKAEIRHL--LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD-HHAAIERRN 421
Q AL+ + EI L L + + + + KL+ ++ EK KSL++ E ++ + ++ N
Sbjct: 391 QQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450
Query: 422 EYNLRKLDEEYKERIAALKNELR---KEREQILQQAGKQRLELEQEIEKAKTEENYIRDR 478
EY + K + + ++LR + +EQ L Q+ ++ L EIE+ +
Sbjct: 451 EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 510
Query: 479 LALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEER 538
+ L + S+ +NE KL + N K LE+ + +LD +Q+E+
Sbjct: 511 MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELD-------VQKEK 563
Query: 539 LTQMR---NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEP 595
L Q N+ + L+D+V+ L +L +
Sbjct: 564 LIQSEVALNDLHLTKQKLEDKVENLVDQLNK----------------------------- 594
Query: 596 EHGLGSEECNPLNMSIEAE-LVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK 654
S+E N +SI+ E L +++ Q+ ++ +R EL + S
Sbjct: 595 -----SQESN---VSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD---------SNS 637
Query: 655 KAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV-- 712
++ + + E E L++ +S+L+ L+ A +K + + E+ + QL+
Sbjct: 638 NFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
Query: 713 ----KLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQEL 768
+L EK + E L+++ + E++A L A+ E + + R L
Sbjct: 698 AGNNQLSLEKNTIVETLKME-KGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSA 756
Query: 769 EQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMET--ECNRRTSQIEAQFQS 826
Q E L L +K +E EL+K + E+ + +E ++ + + E ++ +Q+ + +
Sbjct: 757 LQLEHEHLIKLNQKKDMEIAELKKNI-EQMDTDHKETKDVLSSSLEEQKQLTQLINKKEI 815
Query: 827 DCQKVTERCESALQSLEGRYRQELK--DLQEQQREEKSQWEFEKDELTQECAEAQELLKE 884
+K+ ER S LQ +Y Q L+ ++ Q EEK + E E E L+E
Sbjct: 816 FIEKLKER-SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLRE 874
Query: 885 TLKRE------KTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQD-----LEDLRNVS 932
R KT V E+ + T KEHL + Q++++D ++ L+++
Sbjct: 875 EQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ 934
Query: 933 ETQQSL--LSDQILELKSSHKRELRER-EEVLCQAGASEQLASQ-RLERLEMEHDQER-- 986
E ++ + Q ++ ++H + E+ EE+ EQ+ +Q ER +++ D
Sbjct: 935 EQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIF 994
Query: 987 QEMMSKLLAMEN------IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
QE + L +EN + KA E + E EI L K + + LS +
Sbjct: 995 QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEV 1054
Query: 1041 G--CQVIGEEEVE-------------GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVK 1085
G Q+I ++++E + L QQ + E V L + +
Sbjct: 1055 GKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLN----EKTR 1110
Query: 1086 ENVKMATEISRLQQRLQKLEPGLV--------MSSCLDEPATEFFGNTAEQTEPFLQQNR 1137
EN + TE ++ + E L+ +S+ + + F T + +++ +
Sbjct: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIRE-K 1169
Query: 1138 TKQVEGVTRR--HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET 1195
+++ ++++ +L+ L+ + G +S Q +E+ E + + E ++
Sbjct: 1170 DIEIDALSQKCQTLLAVLQTSSTGNEAG-GVNSNQFEELLQERDKLKQQVKKMEEWKQQV 1228
Query: 1196 RTESWELKNQISQLQEQLMMLCA----DCDRASEKKQDLLFDVSVLKKKLKMLERIPEAS 1251
T ++++ +QLQE+L L A D D S+ + D + ++ L+ +
Sbjct: 1229 MTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQEL 1288
Query: 1252 PKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL 1311
+ + + D L +L ++ + A + +AE R K E ++E+
Sbjct: 1289 AQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQ-SAECLRAS----KSEVLSESSE 1343
Query: 1312 SLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP-DGNIL 1370
L++ +E++ +E + + LQ +L +S+ + LE E E D I
Sbjct: 1344 LLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSE-------LERKEHEQTDSEIK 1396
Query: 1371 QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPR 1430
QL + ++ + ++ ++ + K + Q L N KV +E+ L + +ER
Sbjct: 1397 QLKEK-QDVLQKLLKEKDLLIKAKSD-QLLSSNENFTNKVNENEL--LRQAVTNLKERIL 1452
Query: 1431 V----------QNQVILE----ENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKE 1476
+ +N+ I+E + T Q+ + + + E E E ++E ++
Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512
Query: 1477 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1536
L+K+K+ GE + L A+ + T Q++ +++ +K Q EN+ L+NE+
Sbjct: 1513 ----LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQK-QMENTALQNEV 1567
Query: 1537 TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLD 1596
L +++ SN +L L + + + ++ +E A + L+K+++ L+ K
Sbjct: 1568 QRLRDKEFRSNQELERL---RNHLLESEDSYTREALAAEDREAKLRKKVTVLEEK----- 1619
Query: 1597 LENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQ 1656
L ++ + +N+ +Q +Q + L E L N ++R++ L E+ K Q
Sbjct: 1620 LVSSSNAMENASHQASVQV--ESLQEQL--------NVVSKQRDETALQLSVSQEQVK-Q 1668
Query: 1657 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1716
+ +++L+ L H Q+E + ELEK KQL ++++++ ++
Sbjct: 1669 YALSLANLQMVLE------HFQQEEKAMYSAELEKQKQL-----IAEWKKNAENL---EG 1714
Query: 1717 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1776
K++ +E L +E N+ +D +S L ++ +++ + + Q+ + L Q+K+ +
Sbjct: 1715 KVISLQECL-DEANAALD---SASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMS 1770
Query: 1777 LEDT 1780
L ++
Sbjct: 1771 LANS 1774
Score = 141 bits (355), Expect = 8e-33
Identities = 301/1442 (20%), Positives = 581/1442 (40%), Gaps = 251/1442 (17%)
Query: 325 IENSQEILKAL---DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 381
+ N E++K+ D SLD ++ L L + + L S + +A + R E
Sbjct: 448 LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507
Query: 382 VDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 441
++ K++L ++ + + S + +++D + + + + E ++ +++
Sbjct: 508 TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQS 567
Query: 442 ELRKEREQILQQAGKQRLE-LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 500
E+ + +Q + ++E L ++ K++ E N + L LKE+ R E
Sbjct: 568 EVALNDLHLTKQKLEDKVENLVDQLNKSQ-ESNVSIQKENLELKEHIRQNEE-------- 618
Query: 501 AEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQEERLTQMRNEYERQCRVLQD--- 555
E + N+L ++L F D L AE ++ L+++ E +V D
Sbjct: 619 -ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM 677
Query: 556 -------QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLN 608
++++ +LEE A L L KN+ E ++ G IE E L + L
Sbjct: 678 ENEKLVLACEDVRHQLEECLAGNNQLSLE-KNTIVETLKMEKGEIEAE--LCWAKKRLLE 734
Query: 609 MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 668
+ + E IE++ + + L+LE E ++ +K+ D + KK E M H+
Sbjct: 735 EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK-DMEIAELKKNIEQMDTDHKETK 793
Query: 669 HTL------EKQISDLKNE----IAELQGQAAVLKE---AHHEATCRHE------EEKKQ 709
L +KQ++ L N+ I +L+ +++ L+E + +A ++E EEK +
Sbjct: 794 DVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853
Query: 710 LQVKLEEEKTHLQEKL-RLQHEM----------------ELKARLTQAQASFEREREGL- 751
++EE HLQE+L RL+ E EL + ++Q E E +
Sbjct: 854 SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIK 913
Query: 752 ----------QSSAWTEEKVRGLTQELEQF--HQEQLTSLVEKHTLEKEELRKEL---LE 796
QS + ++ +E+++F EQ+ + + LEK+E K L +E
Sbjct: 914 HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
Query: 797 KHQRELQEGREKMETECNRRTSQIEAQF--------QSDCQKV-TERCESALQSLEGRYR 847
+ + +L E R+ ++T+ + + + Q + D K TER ++ E
Sbjct: 974 QIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE---- 1029
Query: 848 QELKDLQEQQREEKSQW-EFEKDEL--------------------------TQECAEAQE 880
E+K L E+ Q + KDE+ TQ+ Q+
Sbjct: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
Query: 881 LLKE-TLKREKTTSLV--LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS 937
L+ ++REK +++ T+E L+ Y + ++ + + L++ ++ + +S +S
Sbjct: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
Query: 938 LLSDQILELKSSHKRELREREEVL------CQ-----------AGASEQLASQRLERLEM 980
D E + R +RE++ + CQ + + S + E L
Sbjct: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
Query: 981 EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
E D+ +Q+ + K+ + T + E A++ E+ +LQ+++ S L
Sbjct: 1210 ERDKLKQQ-VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKL----- 1263
Query: 1041 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1100
+V+ G + +Q E L+ G L +Q + Q + L +
Sbjct: 1264 --------QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ-------LCNTKDLLLGK 1308
Query: 1101 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1160
L + P L +S L + E A ++E + + Q E R L + +D +R
Sbjct: 1309 LDIISPQLSSASLLTPQSAECL--RASKSEVLSESSELLQQELEELRKSLQE-KDATIRT 1365
Query: 1161 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1220
L Q ++ +S A+ SELE E +T+S E+K Q+ + Q+ L L +
Sbjct: 1366 L--------QENNHRLSDSIAAT---SELERKEHEQTDS-EIK-QLKEKQDVLQKLLKEK 1412
Query: 1221 DRASEKKQD-LLFDVSVLKKKLKMLERIPEASPKYK----LLYEDVSR---ENDCLQEEL 1272
D + K D LL K+ E + +A K +L D+ + EN+ + E
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472
Query: 1273 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1332
R ET Y E N + + + + E M+E F L K ++ K ELN
Sbjct: 1473 RGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK--TGELN---- 1526
Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEE 1392
+L ++ +QE V + E D +L L Q E V + ++
Sbjct: 1527 QLLNAVKSMQEKTVV-------------FQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573
Query: 1393 CKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV-ILEENTTLLGFQDKHF 1451
+ NQ LE +L + E ++ + +++ +V +LEE ++
Sbjct: 1574 EFRSNQELE---RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENA 1630
Query: 1452 QHQATIAELELEKTKLQELTRKLKERVTILVKQKD--VLSHGEKEEELK---AMMHDLQI 1506
HQA++ L+E++ ++ KQ+D L +E++K + +LQ+
Sbjct: 1631 SHQASVQ------------VESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQM 1678
Query: 1507 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1566
QQ+ E Y +E +Q+ I + N E + +L+ E
Sbjct: 1679 VLEHFQQE-EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ---------------EC 1722
Query: 1567 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1626
+ + NAA +++ + +L +K +Q++ EL ++N QE L ++ ++L +
Sbjct: 1723 LDEANAA----LDSASRLTEQLDVKEEQIE----ELKRQNELRQEMLDDVQKKLMSLANS 1774
Query: 1627 KE 1628
E
Sbjct: 1775 SE 1776
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 169 bits (428), Expect = 3e-41
Identities = 296/1353 (21%), Positives = 565/1353 (41%), Gaps = 198/1353 (14%)
Query: 705 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 764
+E + LQ L+EEK + +E L+ E+E L Q +A + +GL + + E ++ L
Sbjct: 90 QEVQDLQASLKEEKWYSEE---LKKELEKYQGLQQQEA----KPDGLVTDSSAE--LQSL 140
Query: 765 TQELEQ-----FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
Q+LE+ F+ +Q+ L E+ + ++ K+ E + RE E + R T +
Sbjct: 141 EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE-RSLREAAEQKVTRLTEE 199
Query: 820 IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQ 879
+ + TE + ++EL +Q + E E ++L EC + Q
Sbjct: 200 LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ 259
Query: 880 ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLL 939
+ ++ ++Q R L K +E + V E Q+L + +L ++T L
Sbjct: 260 S-------QYASSEATISQLRSELAKGPQE-VAVYVQELQKLKSSVNELTQKNQT----L 307
Query: 940 SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME-N 998
++ +L+ + + + + E E ++ + ++ + D + Q++ S+L A E +
Sbjct: 308 TENLLKKEQDYTKLEEKHNE--------ESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359
Query: 999 IHKATCETADR---------ERAEMSTEISRLQSKIKEMQQAT-----------SPLSML 1038
+H+ E +++ E +E+ T+ L+++ K++QQ S ++ L
Sbjct: 360 LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419
Query: 1039 QSGCQVIGEEEVEGDGALSLLQQ--GEQLLEEN---GDVLLSLQRAHEQAVKENVKMATE 1093
S + E G L +Q E+L+++ D+ L L R EQ +KE V +TE
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ-LKEKVTNSTE 478
Query: 1094 ISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRH 1148
LQ +L K + L + T E L+Q + + +E + ++
Sbjct: 479 ---LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 1149 ------VLSDLEDDEVRDLGSTGTSSV--QRQEVKIEESEASVEGFSELENSEETRTESW 1200
+ + ED + G ++V Q QE E + +L+N E+ ++
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKK---QDLLFDVSVLKKKLKMLERIPEASPKYKLL 1257
E N Q+QEQ L A DR + +L ++ K+K+ L+ +A + L
Sbjct: 596 E--NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653
Query: 1258 YE--------DVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME----E 1305
E D+ D Q L+ + ++ ++TA++ Q+ ++E E
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Query: 1306 VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP 1365
E +LSLE+ +E++ + ++L L ++ E+ + + Q+ L +
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ----------RQLNTDL 763
Query: 1366 DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH 1425
+ +L++ LE V S + +++++ LE Q L K + E L +T
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRL---DLQKKSEALESIKQKLTK-QEEEKQILKQDFETL 819
Query: 1426 QERPRVQNQVILEE-NTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ 1484
+ ++Q++ + TT+ Q + +A + EL K KL +++ LK
Sbjct: 820 SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK------ 873
Query: 1485 KDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1543
S EKE + KA + DL+ TC E++ ++++ + K Q+E L+ + E++
Sbjct: 874 ----SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE---LKKSLE--KEKE 924
Query: 1544 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1603
+ LKL LN QE++ Q T+KQ Q++ N+ + + K +Q++ EL
Sbjct: 925 ASHQLKL-ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 1604 ----QKNSQNQEKLQELNQRLTEMLCQKEK--------EPGNSALEE-------REQEKF 1644
QK + Q+L Q E+ +KEK E ++ RE E
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
Query: 1645 NLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ----ENHLLKDELEKMKQL-HRCP 1699
+++L+ + + S L + +++ Q ++Q+ + L +D +K +QL RC
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 1700 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1759
L D Q+ EK LKEKE ++E KS L E +QE K
Sbjct: 1104 ALQDIQK---------EKSLKEKELVNE----------KSKLAEIEEIKCRQE-KEITKL 1143
Query: 1760 SASLKSQLVASQEKVQNLEDT-----VQNVNLQ--MSRMKSDLRVTQQEKEALKQEVMSL 1812
+ LKS + S +++ NL+D Q + LQ +K+ + ++ ++ LK +V
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKE 1203
Query: 1813 HKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1872
++L+ E + LH++ K H NE + L + L +
Sbjct: 1204 EEELKK--------EFIEKEAKLHSEIKEKEVGMKKHEENEAK--LTMQITALNENLGTV 1253
Query: 1873 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQFQKEQ 1925
K E S+ +V +LE + T+ + E+ +L C ++ Q +
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKV 1313
Query: 1926 SPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1958
RK+ + QEL EN+ L+ K +
Sbjct: 1314 LELQRKLDNTTAAVQELGR---ENQSLQIKHTQ 1343
Score = 164 bits (415), Expect = 8e-40
Identities = 291/1350 (21%), Positives = 568/1350 (42%), Gaps = 241/1350 (17%)
Query: 373 AEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD------HHAAIERRNEYNLR 426
AE++ L +++++ E ++ D E+ + +A+E+ D ++ E +
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 427 KLDEEYKER---IAALKNEL------------RKEREQILQQAGKQRLELEQEIEKAKTE 471
+L EE + I LK EL +KE Q+ LE E+E EK K E
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 472 ENYIRDRLALSLKENSRLENELLENAEKLAEY-----------ENLTNKLQRNLENVLAE 520
++ + A S S+L +EL + +++A Y LT K Q EN+L +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 521 K--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
+ + L+ E + ++ + ++ + C+ LQ ++ ++ L + L
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-----LSE 369
Query: 579 KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
K +++++ +E ++ E L E KEQH L+L+ +
Sbjct: 370 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-------KEQH-------GLQLQSE 415
Query: 639 VRHYEKQLDETVVSCKKAQENMKQRHENETHTL---EKQISDLKNEIAELQGQ----AAV 691
+ +L ET +A +K++ + + L E+Q++DL+ +++ L+ Q
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 692 LKEAHH--EATCRHEEEKKQLQ----VKLEEEKTHLQEKLRL-----QHEMELKARLTQA 740
E H + T + +E++ LQ KL E + L++ LR Q L+A L ++
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 741 QAS---FEREREGLQSSAWTEEKVRGLTQELEQFH---QEQLTSLVEK-------HTLEK 787
+ + E+ERE L + E + +L++ + QEQ+T L EK H +
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 788 EELRKELLEK--HQRELQEGREKMETECNRRTSQIEAQFQSDCQ---KVTERCESALQSL 842
E L ++ E+ H R Q+ +ET N SQ+ + Q ++ + E L S
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-LLLSA 654
Query: 843 EGRYRQELKDLQ----------EQQREEKSQWEFEKDELTQECAEAQE---LLKETLKRE 889
E + DLQ + +++E ++ + D++T + + QE L+ LK
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 890 KTTSLVLTQEREMLEKTYKE-HLNSMVVE--RQQLLQDLEDLRNVS---ETQQSLLSDQI 943
K L L Q+ E LE K+ +S+ V+ ++Q LQDL+ R ++ E + + LS Q+
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
Query: 944 ---LELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 1000
E+ SS + +L+++ E L ++L Q E+ ++ D E +K+ E +
Sbjct: 775 EMEKEIVSSTRLDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
Query: 1001 KATCETADRERAEMS-----TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
+ + ++ +M TE+S ++ K+ ++ + L++ +E +G A
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS------LKNSKSEFEKENQKGKAA 886
Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS-RLQQRLQKLEPGLVMSSCL 1114
+ L++ + L+ V + ++ +K++++ E S +L+ L ++ L+ +
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ-- 944
Query: 1115 DEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1169
NT +Q E QQ N KQ ++ + + + ++ L T +
Sbjct: 945 ---------NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995
Query: 1170 QRQEV--KIEESEASVEGFSELENSEETRTESW-ELKNQISQLQEQLMMLCADCDRASEK 1226
+Q++ +E A E S L+N+ E E++ +L++ + +L+ D EK
Sbjct: 996 LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
Query: 1227 ----KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1282
++DL+ + + + + K+++ + A L +D +++ LQE + ++ E
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAK---ATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 1283 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1342
KEL +E K+ E+ E EK E+ NEEL K+E ++
Sbjct: 1113 SLKEKELV-------NEKSKLAEIEEIKCRQEK---EITKLNEELK------SHKLESIK 1156
Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG 1402
E + NL+ D L + Q L E + S+ +E+ K+ Q L
Sbjct: 1157 E--------------ITNLK---DAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQIL-- 1196
Query: 1403 NTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELEL 1462
++QV EE F +K + + I E E+
Sbjct: 1197 -----------------------------KDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227
Query: 1463 EKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES 1522
K +E KL ++T L E L + + Q Q++V L ++
Sbjct: 1228 GMKKHEENEAKLTMQITAL------------NENLGTVKKEWQ----SSQRRVSELEKQT 1271
Query: 1523 EKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1582
+ L+ E ++L E T N +D L L G E E ++ + +Q+ ++N
Sbjct: 1272 DDLRGEIAVL--EATVQNNQDERRALLERCLKGEGE-----IEKLQTKVLELQRKLDNTT 1324
Query: 1583 KQISELKIKNQQLDLENTE-LSQKNSQNQE 1611
+ EL +NQ L +++T+ L++K +++ E
Sbjct: 1325 AAVQELGRENQSLQIKHTQALNRKWAEDNE 1354
Score = 157 bits (396), Expect = 1e-37
Identities = 259/1282 (20%), Positives = 544/1282 (42%), Gaps = 227/1282 (17%)
Query: 847 RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 906
RQE++DLQ +EEK + +EL +E + Q L ++ K + LV E+
Sbjct: 89 RQEVQDLQASLKEEK----WYSEELKKELEKYQGLQQQEAKPD---GLVTDSSAEL---- 137
Query: 907 YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 966
+ L + E Q +++ ++++ E + + L+ +I ++KS + E RE
Sbjct: 138 --QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE-------- 187
Query: 967 SEQLASQRLERLEMEHDQER---QEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
A Q++ RL E ++E Q++ ++LL I + A + E+ ++Q+
Sbjct: 188 ---AAEQKVTRLTEELNKEATVIQDLKTELLQRPGI---------EDVAVLKKELVQVQT 235
Query: 1024 KIKEMQ-QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ 1082
+ M + L+ C+ + + + +S L+
Sbjct: 236 LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR---------------------- 273
Query: 1083 AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
E K E++ Q LQKL+ + + ++ TE N ++ + + + E
Sbjct: 274 --SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE---NLLKKEQDYTKLEEKHNEE 328
Query: 1143 GVTRRHVLS-----DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1197
V+++++ + DL+ +++ S +S+ R V++ E + + E E T
Sbjct: 329 SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK--EELSEVET 386
Query: 1198 ESWELKNQISQLQEQLMMLCADCDRASEKKQ---DLLFDVSVLKKKLKMLERIPEASPKY 1254
+ LK + QLQ+Q EK+Q L +++ L KL ER
Sbjct: 387 KYQHLKAEFKQLQQQ----------REEKEQHGLQLQSEINQLHSKLLETER-------- 428
Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
+ + L+E+ ++ + + + +L ++ RL+++LK E+VT + L+
Sbjct: 429 -----QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK--EKVTNS-TELQ 480
Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC----DCCLWEASLENLEIEPDGNIL 1370
D+ K +++E L K+ + Q + Q D +LE L + NI
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 1371 QLNQTLEECVPRVRSVH---HVIEECKQENQYL-EGNTQLLEKVKAHEIAWLHGTIQTHQ 1426
L + E+ ++++ V+ + +++N L E TQL EK+K ++H+
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--------ESHK 592
Query: 1427 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELE----KTKLQELTRKLKERVTILV 1482
+ + + E+ L QD+ + ++ EL + K K+ +L ++K + +L+
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
Query: 1483 --------KQKDVLSH--------GEKEEELK----------AMMHDLQITCSEMQQKVE 1516
++ D+ +H +K++EL A + D Q CS+++ ++
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 1517 LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQK 1576
+ + L+Q+ L +I L E DS+ + S+E+ Q + +Q N ++
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKL-EADSLE------VKASKEQALQDLQQQRQLNTDLEL 765
Query: 1577 MVENLKKQISELK--IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNS 1634
L KQ+ K + + +LDL+ + E L+ + Q+LT+ ++EK+
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQ---------KKSEALESIKQKLTKQ--EEEKQILKQ 814
Query: 1635 ALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1694
E QE EEL ++Q++ EL +VK++ + E +KD+L K+
Sbjct: 815 DFETLSQETKIQHEELNN-RIQTTV------TELQKVKMEKEALMTELSTVKDKLSKVSD 867
Query: 1695 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1754
L + + + + + + E +EL + +++L E + +K+ +
Sbjct: 868 -----SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK--ELKKSLE 920
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
+ S LK +L + QE++ ++T++ + +++ ++ +Q E K+++ +L
Sbjct: 921 KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1874
+L+ A QK +KL + + Q L E E++ + N +
Sbjct: 981 ELKIA-----------------VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE- 1022
Query: 1875 ELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1934
S+E +QL+S+ + + L T Q+ S++ + Q++ ++
Sbjct: 1023 ---KSQETFKQLQSDFYGRESELL-------ATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 1935 MNSLEQELETIH--LENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQAC 1992
N L QEL+T LE + KK+Q +L E+ +Q ++ + + +L+ +
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQ-QLQERCKALQDIQKEKSLK------EKELVNE--- 1122
Query: 1993 PMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK 2052
+ + +++ + E+ L EEL++ E+ N + ++ ++ +E++ K
Sbjct: 1123 ----KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178
Query: 2053 LKLVKRLL-QEKVNQ--LKEQV 2071
+K + QEK NQ LK+QV
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQV 1200
Score = 93.6 bits (231), Expect = 2e-18
Identities = 181/835 (21%), Positives = 341/835 (40%), Gaps = 155/835 (18%)
Query: 1286 NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE--ELNVLVLR-----LQGKI 1338
N E ++E F +K + E F E +D E N+ + R L+ ++
Sbjct: 33 NNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEV 92
Query: 1339 EKLQESVVQRCDCCLWEAS-----------LENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
+ LQ S+ + W + L+ E +PDG + + L+ S+
Sbjct: 93 QDLQASLKEE----KWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ-------SLE 141
Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQ 1447
+EE + EN ++ L E+ KA ++A I++ + R + ++ T L
Sbjct: 142 QQLEEAQTENFNIKQMKDLFEQ-KAAQLATEIADIKSKYDEERSLREAAEQKVTRLT--- 197
Query: 1448 DKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQIT 1507
EL E T +Q+L +L +R I +DV ++ +++ +M ++ +
Sbjct: 198 ----------EELNKEATVIQDLKTELLQRPGI----EDVAVLKKELVQVQTLMDNMTL- 242
Query: 1508 CSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV 1567
E +++ E L+ E +KLQ + + + E +IS L+ G QE
Sbjct: 243 --ERERESEKLKDECKKLQSQYA---------SSEATISQLRSELAKGPQE--------- 282
Query: 1568 KQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1627
V V+ L+K S + EL+QKN Q LTE L +K
Sbjct: 283 ------VAVYVQELQKLKSSVN-----------ELTQKN-----------QTLTENLLKK 314
Query: 1628 EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD 1687
E++ + LEE+ E+ K+ ++ Q L++ LS + H + E +
Sbjct: 315 EQD--YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 1688 ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSE---ELNSCVDKLAKSSLLEH 1744
+K+K+ +LS+ + K + + ++L +++E + +L S +++L S LLE
Sbjct: 373 ATQKLKE-----ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL-HSKLLE- 425
Query: 1745 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR--VTQ--- 1799
++ LK Q S EK+ + E V ++ L++SR++ L+ VT
Sbjct: 426 -------TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
Query: 1800 ------------QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL 1847
QE++AL+Q + ++ QN + +I + N + L K
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQN-DLEQVLRQIGDKDQKIQNLEALLQKSK- 536
Query: 1848 DHLMNEEQQLLWQENERLQTMVQNTKAE---LTHSREKVRQLESNLLPKHQKHLNPSGTM 1904
E LL +E E L +Q + E L +EK L+ + +K N S
Sbjct: 537 -----ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--- 588
Query: 1905 NPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM 1964
E K + + DQ Q++++ ++ SLE + ++ + K+K +LD Q+
Sbjct: 589 ---ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
Query: 1965 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE----- 2019
L +A + + DLQ A + +Q +L + Q +++ LQ+
Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ-QELNKITTQLDQVTAKLQDKQEHC 704
Query: 2020 -ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
+LE+ E + EQ +E ++ ++E VK ++ + L++Q L
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 167 bits (423), Expect = 1e-40
Identities = 345/1694 (20%), Positives = 696/1694 (41%), Gaps = 259/1694 (15%)
Query: 375 IRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKE 434
+ H ER+ RE + LR +L+K L A + I + ++ KE
Sbjct: 61 LSHSQERLVNETRECQSLRLELEKLNN--QLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
Query: 435 RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKE------NSR 488
+ A K +L + E++ Q+ ++++ EK K E N + L L L E + +
Sbjct: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK-ESNTTKGELQLKLDELQASDVSVK 177
Query: 489 LENELLENAEKLAEYEN--LTNKLQRNLENVLA---EKFGDLDPSSAEFFLQEE---RLT 540
+ LE ++L +N L +L+ + +LA EK ++ ++E RL
Sbjct: 178 YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237
Query: 541 QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKN-------------SPSEEVE 587
+ N + LQ V++L ++L+E + Q + N S +++ E
Sbjct: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
Query: 588 ANSG----GIEPEHGLGSEECNPLNMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHY 642
A S +E H L +E N +I+ L+ +EQ K+Q + E+ +K+
Sbjct: 298 AKSNELTRAVEELHKL-LKEAGEANKAIQDHLLEVEQSKDQMEK-------EMLEKIGRL 349
Query: 643 EKQLDETVVSCKKAQENMKQRHENETHTLEK-------------QISDLKNEIAELQGQA 689
EK+L+ + E E + ++++L N E Q Q
Sbjct: 350 EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409
Query: 690 AVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEM-ELKARLTQAQASFERER 748
+ K + +E K+++ K K +E R Q + L +L QA +R +
Sbjct: 410 LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469
Query: 749 EGL-----QSSAWTEE-------------KVRGLTQELEQ------FHQEQLTS------ 778
E QSS + ++R L ELE+ E+++S
Sbjct: 470 EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
Query: 779 --LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTE--- 833
++ +H + + +EL +++QR L RE ET R Q ++ K+TE
Sbjct: 530 SEVISQHLVSYRNI-EELQQQNQRLLVALRELGETR--EREEQ-----ETTSSKITELQL 581
Query: 834 RCESALQSLEG--RYRQELKDLQEQQREEKSQWEFEKDELTQECA--EAQEL----LKET 885
+ ESAL LE + RQ L + ++ + + T A L L T
Sbjct: 582 KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
Query: 886 LKREKTTSLVLTQER-EMLEKTYKEHLNSMVVERQQLLQDLE----DLRNVSETQQSLLS 940
KR T+ V T ++E T + + + Q++ ++ + + + Q L
Sbjct: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
Query: 941 DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 1000
+Q+ +L+S + + + + AS+R E L+ + R+E+ S E
Sbjct: 702 EQVTDLRSQNTKISTQLD-----------FASKRYEMLQDNVEGYRREITS---LHERNQ 747
Query: 1001 KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLL 1059
K T T +E+ + + ++++ A L++ + + + +E E+ + L
Sbjct: 748 KLTATTQKQEQI--------INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLS 799
Query: 1060 QQGEQLL-EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV-MSSCLDEP 1117
QQ E LL E+ G LL Q + E + T+ RL +++KLE + + L+
Sbjct: 800 QQRESLLAEQRGQNLLLTNLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858
Query: 1118 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHV-LSDLEDDEVRDLGSTGTSSVQRQEVKI 1176
+ T L R Q++ T H+ +L + +++ +T + EV++
Sbjct: 859 VEQRHTLTRNLDVQLLDTKR--QLDTETNLHLNTKELLKNAQKEI-ATLKQHLSNMEVQV 915
Query: 1177 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1236
+ G + N E+ +L +Q+ Q +EQ+ ++ K+ L S
Sbjct: 916 ASQSSQRTGKGQPSNKEDVD----DLVSQLRQTEEQV----------NDLKERLKTSTSN 961
Query: 1237 LKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRL 1296
+++ M+ + E+ K K + E+V + + +E +T+ ++ L E+ E L
Sbjct: 962 VEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL---MEVEKEKQEL 1018
Query: 1297 QDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
QD+ ++ E E LS L+K+ V+ E +E ++ + ++ +
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
+ E+ ++ Q +E V ++ SV +EE Q+ + +QLLE +
Sbjct: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE-----SQLLEC----KA 1129
Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
+W +ER R+ +D+ + +LE + L + KL
Sbjct: 1130 SW--------EERERM--------------LKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 1476 ERVTILVKQK-------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE 1528
++V VK+ + G+ +E++ ++ ++ + + E+ + ES + +Q
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227
Query: 1529 NSILRNEITTLNEEDSISNLKL---GTLNGSQEEMWQKTET---VKQENAAVQKMVENLK 1582
+L E+ L + + K+ EE+ +KTET V + N +++ E L+
Sbjct: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE 1287
Query: 1583 KQISELKIKNQQLDLE-------NTELSQKNS--QNQEKLQE--------LNQRLTEMLC 1625
+ + +++ K ++L+L+ N ELS+K+ Q ++KL E NQ L
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347
Query: 1626 QKEKEPGNSALEERE----------QEKFNLKEELERCKVQ---SSTLVSSLEAELSEVK 1672
+ E L E+E +E LK E+ R + L+ SL+ +L++V+
Sbjct: 1348 DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVR 1407
Query: 1673 IQTHIVQQE-NHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEELN 1730
+ +Q++ + + D EK+K + + + ++ + + + +K+++ S +
Sbjct: 1408 TEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQ 1467
Query: 1731 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1790
+ + L+ + + + KS E Q +L+ L + + +NL++ + ++SR
Sbjct: 1468 EQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNA--GGKSWAPEIATHPSGLHNQQKRLSWDKLD 1848
++ DL+ ++E L+Q++ ++ + A KS +IA H +G+ +Q K +
Sbjct: 1528 LRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS---KIA-HLAGVKDQ-----LTKEN 1578
Query: 1849 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL-------NPS 1901
+ + L Q+ + L + K++ ++ +LE L ++HL PS
Sbjct: 1579 EELKQRNGALDQQKDELDVRITALKSQY---EGRISRLERELREHQERHLEQRDEPQEPS 1635
Query: 1902 GTMNPTEQEKLSLK 1915
+ P +Q +++LK
Sbjct: 1636 NKV-PEQQRQITLK 1648
Score = 150 bits (379), Expect = 1e-35
Identities = 321/1628 (19%), Positives = 677/1628 (41%), Gaps = 278/1628 (17%)
Query: 632 RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 691
R EL + + +L++ + + + +K RHE E+Q +++ ++ Q +
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS--HSQERL 68
Query: 692 LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGL 751
+ E + R E EK Q+K EK + + ++ + ++++ T+ + E E+ L
Sbjct: 69 VNETRECQSLRLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
Query: 752 --------QSSAWTEEKVRGLTQELEQ-----------FHQEQLTSLVEKHTLEKEELRK 792
Q + E V+ L ++L++ + Q + + K+ ++ E K
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
Query: 793 ELLEKHQREL----------------QEGREKMETECN-----RRTSQIEAQF------Q 825
ELL L ++G E +E +CN S++E Q
Sbjct: 188 ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN 247
Query: 826 SDCQKVTERCESALQ-------SLEGRYRQELK---DLQEQQREEKSQWEFEKDELTQEC 875
QK E + L+ S+E ++ EL L + E + +ELT+
Sbjct: 248 EHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAV 307
Query: 876 AEAQELLKETLKREKTTSLVLTQ--------EREMLEKTYK-----EHLNSMV--VERQQ 920
E +LLKE + K L + E+EMLEK + E+ N ++ +R+
Sbjct: 308 EELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367
Query: 921 LLQDLEDLRNVSETQQSL-------------------LSDQILELKSSHKRELREREEVL 961
+ E+L +S T ++ DQ+L K +KR + +E++
Sbjct: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
Query: 962 CQAGASEQLASQRLERLEMEHDQERQEMMSKLL--AMENIHKATCET--ADRERAEMSTE 1017
+ A + + +R E E Q+ +S L AM+ I + +T A+++ + + +
Sbjct: 428 KEVEAKAPILKR--QREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485
Query: 1018 ISRLQSKIKEMQQATSPLSM---LQSGCQVIGEEEVEG---DGALSLLQQG-------EQ 1064
R++ ++K++ Q L M G VI +EEV + ++ Q E+
Sbjct: 486 NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545
Query: 1065 LLEENGDVLLSLQRAHEQAVKENVK-MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFG 1123
L ++N +L++L+ E +E + +++I+ LQ +L+ L + +
Sbjct: 546 LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605
Query: 1124 NTAEQTEPF-LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1182
+ Q + + + ++T V L D+ ST + V + ES +
Sbjct: 606 SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665
Query: 1183 VEGFSEL-------ENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDV 1234
+E + L EN ++ + E+ +++N Q+ +LQEQ+ L R+ K D
Sbjct: 666 IEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL-----RSQNTKISTQLDF 720
Query: 1235 SVLKKKLKML-ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV 1293
+ K+ +ML + + + L+E + Q++ +++ T + N++L
Sbjct: 721 A--SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
Query: 1294 FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL---QGKIEKLQESVVQRCD 1350
R ++ K+ E + + + L + + + E N+L+ L QG +E+ + QR
Sbjct: 779 VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL- 837
Query: 1351 CCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE---NQYLEGNTQLL 1407
+ +E LE E +L +E+ R++ + + K++ L NT+ L
Sbjct: 838 ----SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
K EIA T++ H VQ + +++ G ++ + +L + +
Sbjct: 894 LKNAQKEIA----TLKQHLSNMEVQ---VASQSSQRTGKGQP--SNKEDVDDLVSQLRQT 944
Query: 1468 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527
+E LKER+ + E+ +AM+ L+ + ++ +Q E +R E +
Sbjct: 945 EEQVNDLKERLK---------TSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK 995
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
E++ + ++ E +L Q++ + E+++Q+ + ++K + +++ ++ E
Sbjct: 996 ESAEFQTQLEKKLMEVEKEKQEL------QDDKRRAIESMEQQLSELKKTLSSVQNEVQE 1049
Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKL--QELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1645
++ L N + ++++ Q Q K+ + N+ E++ A +E+ + +
Sbjct: 1050 -ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS 1108
Query: 1646 LKEELE-----------RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM-- 1692
+++ LE CK L+ E+S+ + ++++N LL D++EK+
Sbjct: 1109 VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168
Query: 1693 ------KQLHRCP---DLSD---FQQKISSVLSY--NEKLLKEK---------------- 1722
K+ + P LS+ Q++I +L + EK + E
Sbjct: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRV 1228
Query: 1723 EALSEELNSCVDKL-AKSSLLEHRIATMKQEQ---KSWEHQSASLKSQLVASQEKVQNLE 1778
E L EL D L A+ ++ TM Q + K E + +++ + +EK + LE
Sbjct: 1229 ELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK-ERLE 1287
Query: 1779 DTVQNVNLQMSRMKSDLRVTQQEKEAL--KQEVMSLHKQLQNAGGKSWAPEIATHPSGLH 1836
+Q + ++ +++ D+ Q+ L K ++ K+L K W L
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRW----KARNQHLV 1343
Query: 1837 NQQKRLSWDKLDHLMNEEQ------QLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1890
+QQK ++ L++E++ Q L +E RL+ + + A LT+++ ++ L+ +L
Sbjct: 1344 SQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDL 1403
Query: 1891 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE 1950
N EK +++++ D + + ++Q+ + + +T + E
Sbjct: 1404 --------------NKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT---QYE 1446
Query: 1951 GLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA 2010
LK +Q K+ E T+ S H Q+Q V ++ +L+ L QA
Sbjct: 1447 ELKAQQDKVME----------TSAQSSGDH-------QEQ---HVSVQEMQELKETLNQA 1486
Query: 2011 ERINQHLQEELEN---RTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKV--- 2064
E ++ L+ ++EN SE T N ++E+ ++++ +L +++ LQ++
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARN-------LQEQTVQLQSELSRLRQDLQDRTTQE 1539
Query: 2065 NQLKEQVS 2072
QL++Q++
Sbjct: 1540 EQLRQQIT 1547
Score = 146 bits (368), Expect = 2e-34
Identities = 315/1590 (19%), Positives = 659/1590 (41%), Gaps = 251/1590 (15%)
Query: 634 ELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE-----LQGQ 688
E+E ++ H +++L C+ + +++ + N+ L ++ +L EIA+ +Q Q
Sbjct: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLN-NQLKALTEKNKEL--EIAQDRNIAIQSQ 112
Query: 689 AAVLKE---AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEM--ELKARLTQAQAS 743
KE A R E Q L E+ L EKL+ + EL+ +L + QAS
Sbjct: 113 FTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS 172
Query: 744 ----------FEREREGLQS-SAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTLEKEELR 791
E+E+E L S + W +++ T EL +E+ ++E K LE ++
Sbjct: 173 DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE 232
Query: 792 KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELK 851
LE+ L+ E ++ ++++ + S+E ++ EL
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA------------SMEEKFHNELN 280
Query: 852 ---DLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ--------ER 900
L + E + +ELT+ E +LLKE + K L + E+
Sbjct: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
Query: 901 EMLEKTYK-----EHLNSMV--VERQQLLQDLEDLRNVSETQQSLLS------------- 940
EMLEK + E+ N ++ +R+ + E+L +S T ++
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
Query: 941 ------DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL 994
DQ+L K +KR + +E++ + A + ++ E E E Q+ +S L
Sbjct: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQRE--EYERAQKAVASLSVKL 458
Query: 995 --AMENIHKATCET--ADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS---GCQVIGE 1047
AM+ I + +T A+++ + + + R++ ++K++ Q L M G VI +
Sbjct: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
Query: 1048 EEVEG---DGALSLLQQG-------EQLLEENGDVLLSLQRAHEQAVKENVKM-ATEISR 1096
EEV + ++ Q E+L ++N +L++L+ E +E + +++I+
Sbjct: 519 EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITE 578
Query: 1097 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
LQ +L+ L + + + Q + + + Q GV S L+D
Sbjct: 579 LQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMY--RILLSQTTGVAIPLHASSLDDV 636
Query: 1157 EVRDLG---STGTSSVQRQEVKIEESEASVEGFSEL-------ENSEETRTESWELKN-Q 1205
+ ST + V + ES ++E + L EN ++ + E+ +++N Q
Sbjct: 637 SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ 696
Query: 1206 ISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-YKLLYEDVSRE 1264
+ +LQEQ+ L R+ K D + K+ +ML+ E + L+E +
Sbjct: 697 LEKLQEQVTDL-----RSQNTKISTQLDFA--SKRYEMLQDNVEGYRREITSLHERNQKL 749
Query: 1265 NDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIEN 1324
Q++ +++ T + N++L R ++ K+ E + + + L + + + E
Sbjct: 750 TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQ 809
Query: 1325 EELNVLVLRLQ---GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVP 1381
N+L+ LQ G +E+ + QR + +E LE E +L +E+
Sbjct: 810 RGQNLLLTNLQTIQGILERSETETKQRLS-----SQIEKLEHEISHLKKKLENEVEQRHT 864
Query: 1382 RVRSVHHVIEECKQE---NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE 1438
R++ + + K++ L NT+ L K EIA T++ H VQ +
Sbjct: 865 LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA----TLKQHLSNMEVQ---VAS 917
Query: 1439 ENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELK 1498
+++ G ++ + +L + + +E LKER+ + E+ +
Sbjct: 918 QSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLKERLK---------TSTSNVEQYQ 966
Query: 1499 AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE 1558
AM+ L+ + ++ +Q E +R E +E++ + ++ E +L Q+
Sbjct: 967 AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL------QD 1020
Query: 1559 EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL--QEL 1616
+ + E+++Q+ + ++K + +++ ++ E ++ L N + ++++ Q Q K+ +
Sbjct: 1021 DKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQAKIAVEAQ 1079
Query: 1617 NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER-----------CKVQSSTLVSSLE 1665
N+ E++ A +E+ + ++++ LE CK L+
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139
Query: 1666 AELSEVKIQTHIVQQENHLLKDELEKM--------KQLHRCP---DLSD---FQQKISSV 1711
E+S+ + ++++N LL D++EK+ K+ + P LS+ Q++I +
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
Query: 1712 LSY--NEKLLKEK----------------EALSEELNSCVDKL-AKSSLLEHRIATMKQE 1752
L + EK + E E L EL D L A+ ++ TM Q
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQH 1259
Query: 1753 Q---KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQE- 1808
+ K E + +++ + +EK + LE +Q + ++ +++ D+ Q+ L ++
Sbjct: 1260 EELMKKTETMNVVMETNKMLREEK-ERLEQDLQQMQAKVRKLELDILPLQEANAELSEKS 1318
Query: 1809 -VMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQ------QLLWQE 1861
++ K+L K W L +QQK ++ L++E++ Q L +E
Sbjct: 1319 GMLQAEKKLLEEDVKRWK----ARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374
Query: 1862 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQF 1921
RL+ + + A LT+++ ++ L+ +L N EK +++++ D
Sbjct: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDL--------------NKVRTEKETIQKDLDAK 1420
Query: 1922 QKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ-----------LMEMQHLR 1970
+ + ++Q+ + + +T + E + + K ++ Q + EMQ L+
Sbjct: 1421 IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELK 1480
Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
T L Q + Q LQ+ L + E ++LQE+ SE +
Sbjct: 1481 ET-------------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLL 2060
+ + + T E+ ++ +K + ++ +
Sbjct: 1528 LRQDLQDRTTQEEQLRQQITEKEEKTRKAI 1557
Score = 116 bits (291), Expect = 2e-25
Identities = 217/1055 (20%), Positives = 461/1055 (43%), Gaps = 169/1055 (16%)
Query: 313 VERILDTWQEEGIEN----SQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAAL 368
++ I + +++E EN ++++ K + D T+++ L+ + + Q +
Sbjct: 675 LQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLD--FASKRYEMLQDNV 732
Query: 369 ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV---DDHHAAIERRNEYNL 425
++ EI L ER +KL + K E++ + M ++ ++ A E R E NL
Sbjct: 733 EGYRREITSLHER-------NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAE-NL 784
Query: 426 RKLDEEYKERIAALKNELRKEREQILQQAGKQRLEL------EQEIEKAKTEENYIRDRL 479
+K KE + + L ++RE +L + Q L L + +E+++TE + RL
Sbjct: 785 KK----EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET---KQRL 837
Query: 480 ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 539
+ ++ +LE+E+ +KL + L RNL+ L + LD + +E L
Sbjct: 838 SSQIE---KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
Query: 540 TQMRNEYERQCRVL----------------------QDQVDELQSELEEYRAQGRVLRLP 577
+ E + L ++ VD+L S+L + Q L+
Sbjct: 895 KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954
Query: 578 LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELED 637
LK S S + + E L E+ Q+ E+ ++I + L++
Sbjct: 955 LKTSTSNVEQYQAMVTSLEESLNKEK---------------QVTEEVRKNI---EVRLKE 996
Query: 638 KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 697
++ QL++ ++ +K ++ ++ ++E+Q+S+LK ++ +Q + ++EA
Sbjct: 997 SAE-FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE---VQEALQ 1052
Query: 698 EATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 757
A+ E++ + E+ K ++ + + + E+ L A +A + +E + A
Sbjct: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEA---LQAAKEQVSKMASV 1109
Query: 758 EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRK-----ELLEKHQRELQEGREKMETE 812
+ + TQ+ E E S E+ + K+E+ K E LEK R L + EK+
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS-- 1167
Query: 813 CNRRTSQIEAQFQSDCQ-KVTERCESALQSLE-GRYRQELKDLQEQQRE----EKSQWEF 866
++ + ++ Q ++E +S Q LE R+ + K++ E + E E ++
Sbjct: 1168 -DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
Query: 867 EKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHL----NSMV-VERQQL 921
+ L +E E Q+ L ++ + T+ + Q E+++KT ++ N M+ E+++L
Sbjct: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERL 1286
Query: 922 LQDLEDLR-NVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM 980
QDL+ ++ V + + +L Q + S K + + E+ L + A R + L
Sbjct: 1287 EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA--RNQHLVS 1344
Query: 981 EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
+ E KLL+ + +H + +++ EI RL++ E+ ++ + L+ Q+
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQ-------QLTEEIGRLKA---EIARSNASLTNNQN 1394
Query: 1041 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1100
Q + E+ L+ ++ ++ ++++ D + ++E VK T++ ++ +R
Sbjct: 1395 LIQSLKED-------LNKVRTEKETIQKDLDAKII-------DIQEKVKTITQVKKIGRR 1440
Query: 1101 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1160
+ T++ A+Q + + Q G + +S E E+++
Sbjct: 1441 YK----------------TQYEELKAQQDK---VMETSAQSSGDHQEQHVSVQEMQELKE 1481
Query: 1161 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1220
++ + E K + E+ VE + + +E TE+ L+ Q QLQ +L L D
Sbjct: 1482 -------TLNQAETKSKSLESQVENLQKTLSEKE--TEARNLQEQTVQLQSELSRLRQDL 1532
Query: 1221 -DRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLL---YEDVSRENDCLQEELRMME 1276
DR ++++Q + +K+ K + I A K L + +++EN+ L++ ++
Sbjct: 1533 QDRTTQEEQ---LRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589
Query: 1277 TRYDE------ALENNKELTAEVFRLQDELKKMEE 1305
+ DE AL++ E + RL+ EL++ +E
Sbjct: 1590 QQKDELDVRITALKSQYE--GRISRLERELREHQE 1622
Score = 88.2 bits (217), Expect = 8e-17
Identities = 205/1023 (20%), Positives = 409/1023 (39%), Gaps = 143/1023 (13%)
Query: 1157 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLM 1214
E +L S + E + + ++ ++G + +E +E++ ++S QE+L+
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 1215 MLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRM 1274
+C + + L + L +K K LE + + + + E + + +L
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 1275 METRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
R + LE LT +V RL ++LK E T L+ DE++ + + RL
Sbjct: 130 TNERLSQELE---YLTEDVKRLNEKLK---ESNTTKGELQLKLDELQASDVSVKYREKRL 183
Query: 1335 QGKIEKL-QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1393
+ + E L ++ + L L E IL+L LE V + +
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243
Query: 1394 KQENQYLEGNTQ-LLEKVK------------------AH-EIAWLHGTIQTHQERPRVQN 1433
K N++L+ + + LL K+K AH +++ L+ + E +
Sbjct: 244 KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 1434 QVILEENTTLL---GFQDKHFQHQATIAEL---ELEKTKLQELTRKLKERVTILVKQKDV 1487
+EE LL G +K Q E ++EK L+++ R KE L D+
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE----LENANDL 359
Query: 1488 LSHGEK------EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--- 1538
LS ++ EEEL AM ++ ++L + ++ ++ +L ++
Sbjct: 360 LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI 419
Query: 1539 ---LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
L+E K L +EE E ++ A++ +E K+I L+ +
Sbjct: 420 NKYLDEIVKEVEAKAPILKRQREEY----ERAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475
Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
+ +++ L + N + + ++++L+Q++ +L + E+ GN + + E ++ E V
Sbjct: 476 NKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE---V 532
Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
S LVS E + + Q +V L + E+ +Q +++ Q K+ S L+
Sbjct: 533 ISQHLVSYRNIEELQQQNQRLLVALRE--LGETREREEQETTSSKITELQLKLESALTEL 590
Query: 1716 EKLLKEKEALSEELNSCVDK-----------------LAKSSLLEHRIAT---------- 1748
E+L K ++ + ++S V + L SSL + +A+
Sbjct: 591 EQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQT 650
Query: 1749 ---------------------MKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1787
+KQ Q+ +E+ E+++ L++ V ++ Q
Sbjct: 651 VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQ 710
Query: 1788 MSRMKSDL-------RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE--IATHPSGLHNQ 1838
+++ + L + Q E ++E+ SLH++ Q + E I T L
Sbjct: 711 NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770
Query: 1839 QKRLSWDKL--DHLMNEEQQL------LWQENERLQTMVQNTKAELTHSREKVRQLESNL 1890
++L+ ++ ++L E++ L L Q+ E L + LT+ + LE +
Sbjct: 771 NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE 830
Query: 1891 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVS-QMNSLEQELET---IH 1946
Q+ S + E E LK++ + +++ R + Q+ +++L+T +H
Sbjct: 831 TETKQR---LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLH 887
Query: 1947 LENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQ 2006
L + L K K E QHL + S + Q +E L Q
Sbjct: 888 LNTKELLKNAQK--EIATLKQHLSNMEVQVASQSSQRTGKGQPS-----NKEDVDDLVSQ 940
Query: 2007 LLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQ 2066
L Q E L+E L +TS +N Q + +VT +EE + + +Q + V++ ++ ++ +
Sbjct: 941 LRQTEEQVNDLKERL--KTSTSNVEQ--YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKE 996
Query: 2067 LKE 2069
E
Sbjct: 997 SAE 999
Score = 45.8 bits (107), Expect = 4e-04
Identities = 72/347 (20%), Positives = 146/347 (42%), Gaps = 56/347 (16%)
Query: 1757 EHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR-VTQQEKEALKQEVMSLHKQ 1815
E Q ++ +L SQE++ N Q++ L++ ++ + L+ +T++ KE + ++ Q
Sbjct: 51 EQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQ 110
Query: 1816 LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAE 1875
Q K E+ L +RLS +L++L + ++L NE+L+ TK E
Sbjct: 111 SQFTRTKE---ELEAEKRDLIRTNERLS-QELEYLTEDVKRL----NEKLKES-NTTKGE 161
Query: 1876 L-------------THSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-DQF 1921
L REK + E LL LN + E L+L RE ++
Sbjct: 162 LQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTE--LKTKTDELLALGREKGNEI 219
Query: 1922 QKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHA 1981
+ + K +++ LE+++ + NE L+K L +L E +
Sbjct: 220 LELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAK-------------- 265
Query: 1982 WDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT- 2040
+QQA E+F ++ + + ++ E +++E +L+
Sbjct: 266 ------EQQASM---EEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKE 316
Query: 2041 ------VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPT 2081
+++ ++EVEQ +++ + EK+ +L++++ L S T
Sbjct: 317 AGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
Score = 37.0 bits (84), Expect = 0.20
Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 38/152 (25%)
Query: 322 EEGIENSQEILKALDFSLDGNINLTELTLALENEL--------------------LVTKN 361
E +EN Q+ L + NL E T+ L++EL + K
Sbjct: 1494 ESQVENLQKTLSEKETEAR---NLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE 1550
Query: 362 SIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRN 421
+ A+ + K++I HL DQ+ +E E+L+ ++ K +
Sbjct: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL--------------- 1595
Query: 422 EYNLRKLDEEYKERIAALKNELRKEREQILQQ 453
+ + L +Y+ RI+ L+ ELR+ +E+ L+Q
Sbjct: 1596 DVRITALKSQYEGRISRLERELREHQERHLEQ 1627
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 163 bits (412), Expect = 2e-39
Identities = 378/1794 (21%), Positives = 731/1794 (40%), Gaps = 293/1794 (16%)
Query: 332 LKALDFSLDG-NINLTELTLALEN-ELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 389
L+ + SLD N L +L L N EL + ++ + L IR LE + +
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQS 1255
Query: 390 EKLRS----DLDKAEKLKS----LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 441
+++ ++D EK S L S+ D+ H + N E+ E + A K
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKY 1315
Query: 442 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 501
EL E + ++ +E+ K E + D ++ L EL+E+
Sbjct: 1316 ELVTELNDSRSECITATRKMAEEVGKLLNEVKILND-------DSGLLHGELVEDIPG-G 1367
Query: 502 EYENLTNKLQRNLENVLAEK--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ--- 556
E+ N+ L E + L S E + L + + + ++L DQ
Sbjct: 1368 EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ 1427
Query: 557 ----VDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG---SEECNPLNM 609
+ ELQ+ ++ +A+ VL L+N + V+ G+ E GL S C P +
Sbjct: 1428 MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL--EEGLVPSLSSSCVPDSS 1485
Query: 610 SIEA-------ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 662
S+ + ++EQ + L LE V + +DE V C QE
Sbjct: 1486 SLSSLGDSSFYRALLEQTGDM------SLLSNLEGAVSANQCSVDE--VFCSSLQEENLT 1537
Query: 663 RHENET-----------------HTLEKQISDLKNE----IAELQGQAAVLKEAHHEATC 701
R E + +LEK ++++ E+Q +L E C
Sbjct: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC 1597
Query: 702 RHEE---EKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW-- 756
++ E +Q Q KL ++ KL + + + L A + + L S +
Sbjct: 1598 LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLG 1657
Query: 757 --TEEKVRGLTQ--ELEQFHQEQLTSLVEKHTLEK---EELRKELLEKHQRELQEGREKM 809
TE+ ++G + ++ + H + T KH + + ++ +++L ++ + G K
Sbjct: 1658 IDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKP 1717
Query: 810 ETECNRRTS---------QIEAQFQSDC----------------------------QKVT 832
EC+ S + + Q S+C +V
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK 1777
Query: 833 ERCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDEL---TQECAEAQELLKETL 886
E L+ L E R R +++ L + +E S+ ++ +L + C E ++++ E L
Sbjct: 1778 ETSNENLRLLHVIEDRDR-KVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGE-L 1835
Query: 887 KREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 946
K+E + L+++ E ++E L V + L DLE + ++ + + D + ++
Sbjct: 1836 KKENSD---LSEKLEYFSCDHQE-LLQRVETSEGLNSDLE--MHADKSSREDIGDNVAKV 1889
Query: 947 KSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHK-ATCE 1005
S K + E L + + + AS E L +E D E + L +N +K
Sbjct: 1890 NDSWKERFLDVENELSRIRSEK--ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947
Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLLQQGEQ 1064
+ E + +++E ++L+ ++ M + T+ L L + +E E L +Q E
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007
Query: 1065 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
++E ++L +L V E +K T + Q L+K L ++ C
Sbjct: 2008 EVKEKTELLQTL----SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC----------- 2052
Query: 1125 TAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE 1184
E Q N+ K++ + + L + + L S + +E+ E ++
Sbjct: 2053 --ELENQIAQLNKEKELLVKESESLQARLSESDYEKL----NVSKALEAALVEKGEFALR 2106
Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD-VSVLKKKLKM 1243
S E + R +L+ +I + E+ + A+ + E++ D L D V L+++L+M
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRI-EADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165
Query: 1244 LERIPEA----SPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDE 1299
E E + K E + + + + L++ E + LT ++ Q +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ 2225
Query: 1300 LKKMEEVTETFLSL--EKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC-DCCLWEA 1356
L +++++ +F SL EK E++I+ EE V LQ ++++L E+V C D + +A
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIK-EESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284
Query: 1357 SLENLE--IEPD----GNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1410
+ ++L+ IE + +I +L LE + V ++E + L+G + LE
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-- 2342
Query: 1411 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQEL 1470
+ EIA +T+QE ++ EN+ E+E K K++ +
Sbjct: 2343 RELEIA------RTNQEHAALE-----AENSK---------------GEVETLKAKIEGM 2376
Query: 1471 TRKLK----ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1526
T+ L+ + VTI +++++ + +KE+E + +L+I S + ++ E +++
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQE---RISELEIINSSFENILQEKEQEKVQMK 2433
Query: 1527 QENS----ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1582
+++S +L+ ++ LNE ++ L+ QE A + +NL
Sbjct: 2434 EKSSTAMEMLQTQLKELNE-------RVAALHNDQE--------------ACKAKEQNLS 2472
Query: 1583 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQE 1642
Q+ + L+LE +L Q + + L + ++ +E E G LE++++E
Sbjct: 2473 SQV-------ECLELEKAQLLQGLDEAKNNYIVLQSSVNGLI--QEVEDGKQKLEKKDEE 2523
Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD---ELEKMKQLHRCP 1699
LK +++ LVS +LS+V+ + + +++N L++ ELE+ Q+ +
Sbjct: 2524 ISRLKNQIQ----DQEQLVS----KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575
Query: 1700 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1759
+ S Q + + S + L E E + S V+K+ K + E +++E +
Sbjct: 2576 NAS-LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE---TELQREMHEMAQK 2631
Query: 1760 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1819
+A L+ +L S EK L +Q + ++ K L+ E LK+ + +HK
Sbjct: 2632 TAELQEEL--SGEK-NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688
Query: 1820 GGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1879
GK EIA + LH +K+ Q LL N++ + +Q + +LT
Sbjct: 2689 EGKV-REEIAEYQLRLHEAEKK------------HQALLLDTNKQYEVEIQTYREKLTSK 2735
Query: 1880 RE--KVRQLESNLLPKHQKHLNPS-----GTMNPTEQEKLSLKRECDQFQKEQSPANRK- 1931
E ++LE +LL ++ LN S + ++ K+ + +Q +KE A K
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
Query: 1932 ---VSQMNSLEQELETIHLENEGLKKKQ----------VKLDEQLMEMQHLRST 1972
+ LE+E E + E L+ Q K+DE E++ L+ T
Sbjct: 2796 KLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849
Score = 154 bits (389), Expect = 9e-37
Identities = 392/1938 (20%), Positives = 777/1938 (40%), Gaps = 273/1938 (14%)
Query: 317 LDTWQEEGIENSQEILKALDFSLDGNINLT----ELTLALENELLVTKNSIHQAA----- 367
L+ +E + QE L L F+ + N NL + AL +E+ +N+ A
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130
Query: 368 -LASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIE-RRNEYNL 425
+ + K E + + V+ +++E E+L + + ++L + + + E RN+ N
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190
Query: 426 R-KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS-L 483
+ ++D E KE N + E +L+ + E E+E E + E IR L S L
Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250
Query: 484 KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 543
++ E L++ E AE + ++ + +A +
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGP----------HELSTSQNDNAHLQCSLQTTMNKL 1300
Query: 544 NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 603
NE E+ C +LQ + EL +EL + R++ + +EEV G + E + +++
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSEC----ITATRKMAEEV----GKLLNEVKILNDD 1352
Query: 604 CNPLNMSIEAEL----VIEQMKEQHHRDICCL-------RLELEDK-VRHYEKQLDETVV 651
L+ + ++ EQ EQH + L L L DK V+ + +L E +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412
Query: 652 SCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
S + + + +H + ++S+L+ + L+ + VL + K++Q
Sbjct: 1413 SLQSEHKILHDQHCQ----MSSKMSELQTYVDSLKAENLVLSTNLRNF---QGDLVKEMQ 1465
Query: 712 VKLEE---------------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREG 750
+ LEE + + + L +M L + L A ++ + +
Sbjct: 1466 LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1525
Query: 751 LQSSAWTEEKV-RGLTQELEQFHQEQLTSLVE--KHTLEKEELRKE----LLEKHQRELQ 803
+ S+ EE + R T E+L SL E + +LEK E + E + K +EL+
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585
Query: 804 E--GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE-E 860
+ E+ E +C R+ Q+ S+ ++ ++ S +E + E K ++ E E
Sbjct: 1586 QLLSSERQELDCLRK------QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELE 1639
Query: 861 KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQ 920
++ + + +L+ + R ++ + E E+T K ++ + + Q
Sbjct: 1640 VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQ 1699
Query: 921 LLQDLE-DLRNVSETQQSLLSDQILELKSSHKR-------ELREREEVLCQAGASEQLAS 972
QDL D+ ++ET + + +S + + E + + S A
Sbjct: 1700 --QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757
Query: 973 QRLERLEMEHDQERQEMMSKLLAMENIHKA-TCETADRERAEMSTEISRLQSKI--KEMQ 1029
++ L + D ++ K + EN+ E DR+ + E+ L SK+ +E+Q
Sbjct: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQ 1817
Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQ----QGEQLLEE-------NGDVLLSLQR 1078
T + ++ +++GE + E L+ ++LL+ N D+ + +
Sbjct: 1818 LMTKIEACIELE-KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876
Query: 1079 AHEQAVKENVK------------MATEISRLQQRLQKLE-PGLVMSSCLDEPATEFFGNT 1125
+ + + +NV + E+SR++ +E L + + L+ TE
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-- 1934
Query: 1126 AEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG 1185
+ N KQ V LS + + + G T S + + + SE E
Sbjct: 1935 ------LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEK 1987
Query: 1186 FSELENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
ELE+ + ++ ++ + E L L +D +LL D + L++KL+ L
Sbjct: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS-------ELLKDKTHLQEKLQSL 2040
Query: 1245 ERIPEASPKYKLLYED----VSRENDCLQEELRMMETRYDEA----LENNKELTAEVFRL 1296
E+ +A K E+ +++E + L +E ++ R E+ L +K L A +
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 1297 QDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEA 1356
+ ++ E L + +++++ E L + K+++ + D
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD------ 2154
Query: 1357 SLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA 1416
+ENLE E LQ+++ +E V E K E + L+ TQ+ E ++ ++
Sbjct: 2155 KVENLERE-----LQMSEENQELVILDA------ENSKAEVETLK--TQIEEMARSLKVF 2201
Query: 1417 WLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF---------QHQATIAELELEKTKL 1467
L + E+ + Q+ +E L DK + QA I E KT +
Sbjct: 2202 ELD-LVTLRSEKENLTKQI--QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258
Query: 1468 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527
+ L +LKE + V + +E +KA L E Q + +L+
Sbjct: 2259 EMLQNQLKEL------NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
+ + L E + ++L G + + E+ + QE+AA++ EN K ++
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLEREL--EIARTNQEHAALE--AENSKGEVET 2368
Query: 1588 LKIKNQ---------QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEE 1638
LK K + +LD+ ++N N+ LQ+ +R++E+ + + L+E
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNE--LQKEQERISEL--EIINSSFENILQE 2424
Query: 1639 REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRC 1698
+EQEK +KE+ SST + L+ +L E+ + + + K + + + C
Sbjct: 2425 KEQEKVQMKEK-------SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC 2477
Query: 1699 PDLSD----------------FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL 1742
+L Q ++ ++ E ++ E EE++ +++ L
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537
Query: 1743 EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ-------NLEDTVQNVNLQMSRMKSDL 1795
+++ ++ E + W+ Q+ L++ V ++K+Q +L+DT++ + ++++L
Sbjct: 2538 VSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597
Query: 1796 RVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD---KLDHL 1850
+T+ +K + ++V M+ + A + A L ++ RL+ + L+ +
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657
Query: 1851 MNEEQQL--LWQENERLQTMVQNTKAELTHSREKVRQ--LESNLL-----PKHQKHLNPS 1901
+ + QL L EN L+ + + KVR+ E L KHQ L +
Sbjct: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 1902 GTMNPTE----QEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQV 1957
E +EKL+ K EC QK ++ + S ++EL N LK
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQK------LEIDLLKSSKEEL------NNSLKATTQ 2765
Query: 1958 KLDE-QLMEMQHLR-STATPSPSPHAWDLQLLQQQACPMVPRE-QFLQLQRQLLQAERIN 2014
L+E + +M +L+ + A L ++C + E + LQ + LQA +
Sbjct: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825
Query: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL--QEKVNQLKEQVS 2072
Q ++ + E T ++L +EE+ E ++ L LL EK+ + KE +
Sbjct: 2826 QKTGTVMDTKVDELTT---EIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882
Query: 2073 LP-GHLCSPTSHSSFNSS 2089
HLCS S S
Sbjct: 2883 TQVAHLCSQQSKQDSRGS 2900
Score = 139 bits (350), Expect = 3e-32
Identities = 248/1139 (21%), Positives = 484/1139 (42%), Gaps = 196/1139 (17%)
Query: 284 RRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNI 343
+R TS + S + + +G +V ++ D+W+E ++ E+ + S +I
Sbjct: 1858 QRVETSEGLNSDLEMHADKSSREDIGD-NVAKVNDSWKERFLDVENELSRIR--SEKASI 1914
Query: 344 NLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLK 403
L L + E++ T+ + + + I L E + V E+ +LR +LD K
Sbjct: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974
Query: 404 SLM---ASEVDDHHAAIERRNE---YNLRKLDEEYKERIAALK------NELRKEREQI- 450
+ + + ++ + +E + ++ + E KE+ L+ +EL K++ +
Sbjct: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034
Query: 451 --LQQAGKQ-------RLELEQEIEKAKTEENYI-------RDRLALS----LKENSRLE 490
LQ K + ELE +I + E+ + + RL+ S L + LE
Sbjct: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
Query: 491 NELLENAE---KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 547
L+E E +L+ + ++L+R +E + D ++ + + E E
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK--------KQLHIAEKLKERE 2146
Query: 548 RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
R+ L+D+V+ L+ EL+ ++ L +NS +E + E L E + +
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENE 667
+ E E + +Q++E+ + EL+ + ++ L+E ++A+ +K+ +
Sbjct: 2207 TLRSEKENLTKQIQEKQGQ-----LSELDKLLSSFKSLLEEK----EQAEIQIKEESKTA 2257
Query: 668 THTLEKQISDLKNEIAELQGQAAVLK----------EAHHEATCRHE--------EEKKQ 709
L+ Q+ +L +A L G ++K E H+ E +EKKQ
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
Query: 710 LQV--KLEEEKTH---LQEKL-RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 763
L V +L+E + H L+ ++ L+ E+E+ AR Q A+ E E + + K+ G
Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEI-ARTNQEHAALEAENSKGEVET-LKAKIEG 2375
Query: 764 LTQELEQFHQEQLTSLVEK----HTLEKEELR---KELLEKHQRELQEGREKMETECNRR 816
+TQ L + +T EK + L+KE+ R E++ + + +E+ + + +
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435
Query: 817 TSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQEC 875
+S Q+ +++ ER +AL + QE +EQ + + E EK +L Q
Sbjct: 2436 SSTAMEMLQTQLKELNERV-AALHN-----DQEACKAKEQNLSSQVECLELEKAQLLQGL 2489
Query: 876 AEAQELLKETLKREKTTSLVLTQE--REMLEKTYKE--HLNSMVVERQQLLQDLEDLRNV 931
EA+ + + L+ E ++ LEK +E L + + +++QL+ L +
Sbjct: 2490 DEAKN--NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV--- 2544
Query: 932 SETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEM-- 989
E + L +Q LEL++ EL ++ +VL AS Q LE L+ + E+
Sbjct: 2545 -EGEHQLWKEQNLELRNL-TVELEQKIQVLQSKNASLQ---DTLEVLQSSYKNLENELEL 2599
Query: 990 --MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSG--CQVI 1045
M K+ +E ++K T + + LQ ++ EM Q T+ L SG ++
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETE------------LQREMHEMAQKTAELQEELSGEKNRLA 2647
Query: 1046 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1105
GE ++ + S Q ++L EN ++ SL H+ V++ K+ EI+ Q RL + E
Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAE 2707
Query: 1106 PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG 1165
+ L N+ +VE T R L+ E+
Sbjct: 2708 --------------------KKHQALLLDTNKQYEVEIQTYREKLTSKEE---------- 2737
Query: 1166 TSSVQRQEVKI-----EESEASVEGFSE-LENSEETRTESWELKNQI----SQLQEQLMM 1215
S Q+ E+ + EE S++ ++ LE ++T+ ++ + NQ+ + Q ++ +
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKL 2797
Query: 1216 LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1275
L C + E+K+ +L+K+L L+ E Q+ +M
Sbjct: 2798 LIKSCKQLEEEKE-------ILQKELSQLQAAQEK------------------QKTGTVM 2832
Query: 1276 ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
+T+ DE KEL L+++ K+ +E + + SL S+++++ E L V L
Sbjct: 2833 DTKVDELTTEIKELKE---TLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888
Score = 139 bits (349), Expect = 4e-32
Identities = 397/1980 (20%), Positives = 776/1980 (39%), Gaps = 343/1980 (17%)
Query: 262 SASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQ 321
S+++ ++R S F SG + T S T IG R ++S +LD
Sbjct: 229 SSNSQRTPIRRDFSASYF--SGEQEVTPSRSTLQIGKR--DANSSFFDNSSSPHLLDQ-- 282
Query: 322 EEGIENSQEILKALDFSLDGNINLTELTL-ALENELLVTKNSIHQAALASFKAEIRHLLE 380
LKA + L IN EL L E E+ N + L KA++ L+E
Sbjct: 283 ----------LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVE-LIE 331
Query: 381 RV-------DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR-KLDEEY 432
+ D++VR + K L+ + +D + +R+N + R L+++
Sbjct: 332 KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTED--LSCQRQNAESARCSLEQKI 389
Query: 433 KERIAALKNELRKER---EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRL 489
KE+ + EL +++ + + Q+ + + L QE+++AK N ++ L +L
Sbjct: 390 KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 490 ENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 549
EN L E +KL E Q ++E L + E +++
Sbjct: 450 ENNLEEFKQKLCRAEQAFQASQ----------------------IKENELRRSMEEMKKE 487
Query: 550 CRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNM 609
+L+ ++ E+ A+ + ++ L S + +EE N
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN----------------FAEEMKAKNT 531
Query: 610 SIEAELVIEQMKEQHHRDICCLRLE-LEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 668
S E ++ ++E+ ++ L LE L+ V EKQ D + KK + +++Q ++ +
Sbjct: 532 S--QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 669 HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 728
T EK+ L + + + + LKE +C E +K L ++E EK +LQ K+
Sbjct: 590 KT-EKESKALLSALELKKKEYEELKEEKTLFSCWKSENEK-LLTQMESEKENLQSKIN-H 646
Query: 729 HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 788
E LK + ++ ER R E L+ E+ H + VE T +
Sbjct: 647 LETCLKTQQIKSHEYNERVRT-------LEMDRENLSVEIRNLHNVLDSKSVEVETQKLA 699
Query: 789 ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 848
+ EL +K + Q+ ++++E C +TSQ+ Q E E LQ L
Sbjct: 700 YM--ELQQKAEFSDQKHQKEIENMC-LKTSQLTGQ--------VEDLEHKLQLLS----N 744
Query: 849 ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 908
E+ D ++ +++E +D L + +A + E +R SL+ ++ + ++
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSK--DASLVTNEDHQR----SLLAFDQQPAMHHSFA 798
Query: 909 EHL---NSMVVERQQ-------------LLQDLEDLRNVS-ETQQSLLSD------QILE 945
+ SM ER + +LQ+ D S E+Q+ + SD ++++
Sbjct: 799 NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858
Query: 946 LKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA--- 1002
+K + L + E+ + Q+ +E SQR+ +L+ + + + L A+EN K
Sbjct: 859 IKGEIEENLMKAEQ-MHQSFVAE--TSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915
Query: 1003 ---TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSL- 1058
ET E E+ L+ +KE+Q + LS+ E+ E +SL
Sbjct: 916 LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL----------EKKEMSSIISLN 965
Query: 1059 LQQGEQLLEENG---DVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
++ E+L +ENG ++ SL + ++++ A I ++ + +L +
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
E GN E +++++ + ++ ++ L + TS + ++ +
Sbjct: 1026 LQRCEETGNA---------------YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNE 1070
Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
+E+ + E F++ T+ E +NQ L+ + + + ++ + + +
Sbjct: 1071 LEQLK---EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE-MTDNQNNSKSEAG 1126
Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYD------EALENN-KE 1288
LK+++ L+ E K + D+ +EN+ L +++M+T+++ E + N+ KE
Sbjct: 1127 GLKQEIMTLK---EEQNKMQKEVNDLLQENEQL---MKVMKTKHECQNLESEPIRNSVKE 1180
Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR 1348
+E R Q K ++ +SL+ SY N +L L L+ K KLQES ++
Sbjct: 1181 RESE--RNQCNFKPQMDLEVKEISLD-SY------NAQLVQLEAMLRNKELKLQESEKEK 1231
Query: 1349 CDCCLWEASLENLEIEPDGNILQLNQT-----LEECVPRVRSVHHVIEECKQENQYLEGN 1403
+C E L+ + + + + LQ Q+ L++C E E +Y+ G
Sbjct: 1232 -ECLQHE--LQTIRGDLETSNLQDMQSQEISGLKDC------------EIDAEEKYISGP 1276
Query: 1404 TQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELE 1463
+L ++ A L ++QT + LE+ +L + + EL
Sbjct: 1277 HEL--STSQNDNAHLQCSLQTTMNKLNE-----LEKICEIL-----QAEKYELVTELNDS 1324
Query: 1464 KTKLQELTRKLKERVTILVKQKDVLS------HGEKEEELKA--------MMHDLQITCS 1509
+++ TRK+ E V L+ + +L+ HGE E++ H + +
Sbjct: 1325 RSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL 1384
Query: 1510 EMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ 1569
+ E L +++Q + L+ + +L E I + + ++ E+ +++K
Sbjct: 1385 DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKA 1444
Query: 1570 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS---------------------- 1607
EN + + N + + +K QL LE + +S
Sbjct: 1445 ENLVLSTNLRNFQGDL----VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALL 1500
Query: 1608 ---------QNQEKLQELNQ-RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQS 1657
N E NQ + E+ C +E + E ++E C+V
Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYR 1560
Query: 1658 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHR--CPDLSDFQQKISSV-LSY 1714
+L E S+ ++ +Q+ LL E +++ L + + +QQK++SV L
Sbjct: 1561 QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM 1620
Query: 1715 NEKLLKEK---EALSEELNSCVDKLAKSSLLEHRIATMKQEQK----------SWEHQSA 1761
KL EK E LS EL +L L + + E S EH S
Sbjct: 1621 ESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE 1680
Query: 1762 SLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVT---------------QQEKEALK 1806
+ + ++ + +D Q++NL + ++ V + E
Sbjct: 1681 TTERTPKHDVHQICD-KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739
Query: 1807 QEVMSLHKQLQNAGGKSWAP-EIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERL 1865
Q +L +G + P + + +HN Q R+ NE +LL +R
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK-----ETSNENLRLLHVIEDR- 1793
Query: 1866 QTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQ 1925
V++ E+ K+ E L+ K + + + ++E L + + F +
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853
Query: 1926 SPANRKVSQMNSLEQELE-------------TIHLENEGLKKKQVKLDEQLMEMQHLRST 1972
++V L +LE + N+ K++ + ++ +L ++ +++
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913
Query: 1973 ATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2032
DL+++Q + L L++ +++ L+EEL TSE N +
Sbjct: 1914 IEHEALYLEADLEVVQTEK---------LCLEKDNENKQKVIVCLEEELSVVTSERNQLR 1964
Query: 2033 GN----------QEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTS 2082
G +QL M+E+ E+E +Q ++KE+ L L S S
Sbjct: 1965 GELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024
Score = 132 bits (331), Expect = 5e-30
Identities = 348/1759 (19%), Positives = 673/1759 (38%), Gaps = 303/1759 (17%)
Query: 443 LRKEREQILQQAGKQRLELEQEIEKAKTEEN---YIRDRLALSL-KENSRLENELLENAE 498
L + +E + +A ++ ELE +++K K E+ + D L +L K+ ++ENE E
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63
Query: 499 KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 558
NL + QR +E E L + + + + +V + QV+
Sbjct: 64 ------NLKRENQRLMEIC-------------------ESLEKTKQKISHELQVKESQVN 98
Query: 559 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 618
+ +L + Q L LK SE + + L NP N +
Sbjct: 99 FQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSL-----NPCNTPQKI----- 148
Query: 619 QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDL 678
+ L + E++K+++ E ++ +++
Sbjct: 149 -----------------------FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185
Query: 679 KNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 738
K A+ Q +H RH+ + E+ +HL + R
Sbjct: 186 KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-----SNSQRTPIRRD 240
Query: 739 QAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH 798
+ + F E+E S + + R F L+++ + +ELR ++ E
Sbjct: 241 FSASYFSGEQEVTPSRSTLQIGKRDANSSF--FDNSSSPHLLDQLKAQNQELRNKINELE 298
Query: 799 QRELQEGREKMETECNRRTSQIEAQFQS------DCQKVTERCESALQSLEGRY------ 846
R LQ ++M+ + N + +++ Q + + +KV +C L +Y
Sbjct: 299 LR-LQGHEKEMKGQVN-KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTK 356
Query: 847 ----RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREM 902
Q+LK L E ++ E + L Q+ E ++ +E L R++ + L QE
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE--- 413
Query: 903 LEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLC 962
+ + +L Q+L+ +N+ Q+ L D++ +K + L E ++ LC
Sbjct: 414 -----------CIQMKARLTQELQQAKNMHNVLQAEL-DKLTSVKQQLENNLEEFKQKLC 461
Query: 963 ---QAGASEQLASQRLER-----------LEMEHDQERQEMMSKLLAMENIHKAT----- 1003
QA + Q+ L R L+ +Q+ +E+ ++NI +
Sbjct: 462 RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521
Query: 1004 -CETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQG 1062
E + T + LQ KI + + + + L+ + + E + D + LL++
Sbjct: 522 FAEEMKAKNTSQETMLRDLQEKINQQENSLT----LEKLKLAVADLEKQRDCSQDLLKKR 577
Query: 1063 EQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFF 1122
E +E+ D L + KE+ + + + ++ ++L+ + SC +
Sbjct: 578 EHHIEQLNDKL-------SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630
Query: 1123 GNTAEQTEPFLQQ-------NRTKQVEGVTRRHVLSDLEDD------EVRDLGSTGTS-- 1167
+ E + +T+Q++ + LE D E+R+L + S
Sbjct: 631 TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690
Query: 1168 -SVQRQEVKIEESEASVEGFSELENSEETRT---ESWELKNQISQLQEQLMMLCADCDRA 1223
V+ Q++ E + E FS+ ++ +E ++ +L Q+ L+ +L +L +
Sbjct: 691 VEVETQKLAYMELQQKAE-FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDK 749
Query: 1224 SEKKQDLLFDVSVLKKKLKMLER-------------IPEASPKYKLLYEDVSRENDCLQE 1270
QDL + L+ LK + + P + ++ E +
Sbjct: 750 DRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPS 809
Query: 1271 ELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT-------ETFLSLEKSYDEVKIE 1323
E D++ +N+ L V L+ L+ +++ E + ++ +E ++
Sbjct: 810 ERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMK 869
Query: 1324 NEELN-VLVLRLQGKIEKLQESVVQRCDCCLWEAS-LENLEIEPDGNILQL----NQTLE 1377
E+++ V +I KLQE + S LEN E E LQL +T +
Sbjct: 870 AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE-----LQLLNDKVETEQ 924
Query: 1378 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVIL 1437
+ ++ +H++E+ +E Q L T LEK + I L+ + E +N +
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLL-SETLSLEKKEMSSIISLN---KREIEELTQENGTLK 980
Query: 1438 EENTTLLGFQDKHFQHQATIAELELEKTK-LQELTRKLKERVTILVKQKDVLSHG----- 1491
E N +L + Q + A E+ K + EL+ + K+ IL+++ + +
Sbjct: 981 EINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLS 1040
Query: 1492 -------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDS 1544
EK +L+ ++++ C + ++E L+ E +E+ ++ E +
Sbjct: 1041 QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK---EAFAKEHQEFLTKLAFAEERNQ 1097
Query: 1545 ISNLKLGTLNGS-QEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1603
L+L T+ + + EM K E LK++I LK + ++ E +L
Sbjct: 1098 NLMLELETVQQALRSEMTDNQNNSKSE-------AGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Query: 1604 QKNSQNQEKLQELNQRLTEMLCQK-EKEPGNSALEEREQEK--FNLKEELERCKVQSSTL 1660
Q+N Q + ++ T+ CQ E EP ++++ERE E+ N K +++ +V+ +L
Sbjct: 1151 QENEQLMKVMK------TKHECQNLESEPIRNSVKERESERNQCNFKPQMD-LEVKEISL 1203
Query: 1661 VS------SLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQ-QKISSV-- 1711
S LEA L +++ ++E L+ EL+ ++ +L D Q Q+IS +
Sbjct: 1204 DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD 1263
Query: 1712 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1769
+ EK + LS N D L+ + + + +K E A
Sbjct: 1264 CEIDAEEKYISGPHELSTSQN---DNAHLQCSLQTTMNKLNELEKICEILQAE------- 1313
Query: 1770 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQN--AGGKSWAPE 1827
E V L D+ +M ++ E + L + LH +L GG E
Sbjct: 1314 KYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGG-----E 1368
Query: 1828 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLE 1887
P N+Q +S LD N + L + E VQ AEL +EK L+
Sbjct: 1369 FGEQP----NEQHPVSLAPLDE-SNSYEHLTLSDKE-----VQMHFAEL---QEKFLSLQ 1415
Query: 1888 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHL 1947
S H +H S M+ + SLK E +L +
Sbjct: 1416 SEHKILHDQHCQMSSKMSELQTYVDSLKAE-------------------NLVLSTNLRNF 1456
Query: 1948 ENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQF--LQLQR 2005
+ + +K+ Q+ L+E L + L S+ P S L L + EQ + L
Sbjct: 1457 QGDLVKEMQLGLEEGL--VPSLSSSCVPDSS----SLSSLGDSSFYRALLEQTGDMSLLS 1510
Query: 2006 QLLQAERINQ---------HLQEELENRTSETNTPQGNQEQLVTVME---ERMIEVEQKL 2053
L A NQ LQEE R + P E+L ++ E + + ++E+K+
Sbjct: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570
Query: 2054 KLVKRLLQEKVNQLKEQVS 2072
+ + +++ +L++ +S
Sbjct: 1571 ESQGIMKNKEIQELEQLLS 1589
Score = 127 bits (319), Expect = 1e-28
Identities = 379/1818 (20%), Positives = 734/1818 (40%), Gaps = 256/1818 (14%)
Query: 317 LDTWQEEGIENSQEILKALDFSLDG--------NINLTELTLALENELLVTKNSIHQAAL 368
L+ W+E + + ++ L+ LD L L AL+ + +N +
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63
Query: 369 ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKL 428
+ K E + L+E + + + K+K+ +L E + +++ IE+ + R
Sbjct: 64 -NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 429 DEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 488
E + + AA ++ Q+ L Q +K E+ ++++ ++E R
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED--LKEKYNKEVEERKR 180
Query: 489 LENELLE-NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 547
LE E+ A+K ++ R++ A SS+ F Q+E+ +
Sbjct: 181 LEAEVKALQAKKASQTLPQATMNHRDIARHQA--------SSSVFSWQQEKTPSHLSSNS 232
Query: 548 RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
++ + +D S +E L++ +++ S + NS L ++
Sbjct: 233 QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFD-NSSSPHLLDQLKAQNQELR 291
Query: 608 NMSIEAELVIE----QMKEQHHRDICCLRLELED-KVRHYEKQLDETVVSCKKAQENMKQ 662
N E EL ++ +MK Q ++ L+L+LE KV EK ++ + C+
Sbjct: 292 NKINELELRLQGHEKEMKGQVNK-FQELQLQLEKAKVELIEK--EKVLNKCRDELVRTTA 348
Query: 663 RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
+++ + + + L+ ++ +L + ++ A C E++ K+ + + +EE + Q
Sbjct: 349 QYDQAS----TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
Query: 723 EKLRL--QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
+ Q +++KARLTQ + LQ+ +K+ + Q+LE +E
Sbjct: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL---DKLTSVKQQLENNLEE------ 455
Query: 781 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERC--ESA 838
K L + E + + + EL+ E+M+ E N S E QK E C E+
Sbjct: 456 FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE-------QKAREVCHLEAE 508
Query: 839 LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 898
L++++ Q +E + + SQ +D QE QE +L EK V
Sbjct: 509 LKNIKQCLNQSQNFAEEMKAKNTSQETMLRD--LQEKINQQE---NSLTLEKLKLAVADL 563
Query: 899 EREMLEKTYKEHLNSMVVERQQLLQDLED-LRNVSETQQSLLSDQILELKSSHKRELRER 957
E++ ++ ++ +R+ ++ L D L + ++LLS LELK EL+E
Sbjct: 564 EKQ------RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS--ALELKKKEYEELKE- 614
Query: 958 EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA----------TCETA 1007
E+ L SE E+L + + E++ + SK+ +E K T
Sbjct: 615 EKTLFSCWKSEN------EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668
Query: 1008 DRERAEMSTEISRLQSKI--KEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
+ +R +S EI L + + K ++ T L+ ++ LQQ +
Sbjct: 669 EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME-------------------LQQKAEF 709
Query: 1066 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNT 1125
++ H+ KE M + S+L +++ LE L + S + +
Sbjct: 710 SDQK----------HQ---KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756
Query: 1126 AEQTEPFLQQNRTKQVEGVTRR-HVLSDLEDDE--------VRDLGSTGTSSVQRQEVKI 1176
+ E ++K VT H S L D+ +G G+ +R E ++
Sbjct: 757 HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL 816
Query: 1177 EESEASVEGFSELENSEETRTESWELKNQI-SQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
E++ S + + L+N ++ S E + Q+ S LQ+Q C+ + K ++ + +
Sbjct: 817 -EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ-------CEELVQIKGEI--EEN 866
Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
++K + + E S + L ED S + + E L +E + E N ++ E
Sbjct: 867 LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926
Query: 1296 LQDELKKMEEVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIEKL--QESVVQRCDCC 1352
+Q ELKK + E L L+ + + +E +E++ ++ + +IE+L + ++ +
Sbjct: 927 IQ-ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985
Query: 1353 LWEASLENLEIEPDGNILQLNQTLEECV-PRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1411
L + + N++Q +++ + R +S+ + ++ KQE L + E
Sbjct: 986 LNQEKM---------NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE--ETGN 1034
Query: 1412 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1471
A+E L + QE+ + + +L E T+L E K +L++L
Sbjct: 1035 AYED--LSQKYKAAQEK-NSKLECLLNECTSL----------------CENRKNELEQLK 1075
Query: 1472 RKL-KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESE-KLQQEN 1529
KE L K L+ E+ + +L + +QQ + +++ + E
Sbjct: 1076 EAFAKEHQEFLTK----LAFAEERNQ------NLMLELETVQQALRSEMTDNQNNSKSEA 1125
Query: 1530 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQ----KTETVKQENAAVQKMVENLKKQI 1585
L+ EI TL EE + ++ L E++ + K E E+ ++ V+ + +
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185
Query: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1645
++ K Q+DLE E+S +S N + +Q L ML KE + L+E E+EK
Sbjct: 1186 NQCNFK-PQMDLEVKEIS-LDSYNAQLVQ-----LEAMLRNKELK-----LQESEKEKEC 1233
Query: 1646 LKEELE--RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL-KDELEKMK--QLHRCPD 1700
L+ EL+ R +++S L E+S +K I +E ++ EL + H
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGLK-DCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292
Query: 1701 LSDFQQKISSVLSYNEKLLKEKEALSEELN-SCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1759
L K++ + E L EK L ELN S + + + + + + E K
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352
Query: 1760 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1819
S L +LV + E + + ++ + E+ E ++L +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL----------DESNSYEHLTLSDK---- 1398
Query: 1820 GGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1879
E+ H + L Q+K LS +++++ + + LQT V + KAE
Sbjct: 1399 -------EVQMHFAEL--QEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449
Query: 1880 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLE 1939
+R + +L+ + Q L E SL C S LE
Sbjct: 1450 STNLRNFQGDLVKEMQLGLE--------EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLE 1501
Query: 1940 QELETIHLEN-EG-LKKKQVKLDE---QLMEMQHLRSTATPS-PSPHAWDLQLLQQQACP 1993
Q + L N EG + Q +DE ++ ++L TPS P+ +L+ L +
Sbjct: 1502 QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCE---- 1557
Query: 1994 MVPREQFLQLQRQL-LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK 2052
V R+ +L+ ++ Q N+ +QE + +SE ++Q ++ E + +QK
Sbjct: 1558 -VYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE----QWQQK 1612
Query: 2053 LKLVKRLLQEKVNQLKEQ 2070
L V ++ K+ K+Q
Sbjct: 1613 LTSVTLEMESKLAAEKKQ 1630
Score = 62.8 bits (151), Expect = 3e-09
Identities = 109/522 (20%), Positives = 222/522 (42%), Gaps = 68/522 (13%)
Query: 1573 AVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG 1632
A+QK ++ L+ Q+ +LK + QQ + L + ++K++ N++ ++E +
Sbjct: 16 ALQK-IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE--NEKTEGTNLKRENQRL 72
Query: 1633 NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM 1692
E E+ K + EL+ + Q V+ E +L+ K Q ++QE K ELE+
Sbjct: 73 MEICESLEKTKQKISHELQVKESQ----VNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128
Query: 1693 KQLHRCPDLS----DFQQKI-SSVLSYNEKLLKEK-EALSEELNSCVDKLAKSSLLEHRI 1746
+Q + D+S + QKI ++ L+ ++ K E L E+ N V++ + LE +
Sbjct: 129 QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR---LEAEV 185
Query: 1747 ATMKQEQKSWEHQSASLKSQLVASQEKVQNL-----EDTVQNV--NLQMSRMKSDLRVTQ 1799
++ ++ S A++ + +A + ++ E T ++ N Q + ++ D +
Sbjct: 186 KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
Query: 1800 QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLW 1859
E QEV LQ G + + S H LD L + Q+L
Sbjct: 246 FSGE---QEVTPSRSTLQ-IGKRDANSSFFDNSSSPH---------LLDQLKAQNQELRN 292
Query: 1860 QENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECD 1919
+ NE L+ +Q + E+ K ++L+ L + + +N E + + D
Sbjct: 293 KINE-LELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 1920 QFQKEQSPANRKVSQ----MNSLEQELETIHLE-NEGLKKKQVKLDEQLMEMQHLRSTAT 1974
Q + + +K+ + ++ Q E+ + +K+K+ + E+L Q
Sbjct: 352 QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR------ 405
Query: 1975 PSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGN 2034
Q L Q+ M R L ++L QA+ ++ LQ EL+ TS + N
Sbjct: 406 --------SFQTLDQECIQMKAR-----LTQELQQAKNMHNVLQAELDKLTSVKQQLENN 452
Query: 2035 QEQLVTVMEERMIEVEQKL---KLVKRLLQEKVNQLKEQVSL 2073
E+ ++++ EQ ++ + L+ + ++K++ +L
Sbjct: 453 LEE----FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 160 bits (404), Expect = 2e-38
Identities = 338/1582 (21%), Positives = 638/1582 (40%), Gaps = 254/1582 (16%)
Query: 347 ELTLALENELLVTKNS--------IHQAALASFKAEIRHLLERVDQVVREKE-----KLR 393
EL LA +LL K++ I + AL + K L + + +R+K +L
Sbjct: 234 ELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293
Query: 394 SDLDKAEKLKSLMASEVDDHHAAIERRN---EYNLRKLDEEYKERIAALKNELRKEREQI 450
L + + LK+ S++D + N + LR+ ++ AL NEL +E +
Sbjct: 294 ETLKQCQDLKT-EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDAL-NELTEEHSKA 351
Query: 451 LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL 510
Q+ +++ +LE+E+ A ++ + ++ NE+L+ KL++ E ++L
Sbjct: 352 TQEWLEKQAQLEKELSAALQDKKCLEEK------------NEILQG--KLSQLEEHLSQL 397
Query: 511 QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE------- 563
Q N E GD+ L++E T N + Q RV + + Q E
Sbjct: 398 QDNPPQEKGEVLGDVLQLET---LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER 454
Query: 564 --LEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV-IEQM 620
EE + Q L L++S S +A + G+ + S+ +EL +
Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQV-ASLTSELTTLNAT 513
Query: 621 KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKN 680
+Q +++ L+ + ++K + QL +T+ ++A + ++ + E + +L+++ LK
Sbjct: 514 IQQQDQELAGLKQQAKEK----QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK- 568
Query: 681 EIAELQGQAAVLKEAHHEATCRHEEEK---------KQLQVKLEEEKTHLQEKLRLQHEM 731
E+AE Q +A A AT E E KQL+ LE+EK E L+ Q ++
Sbjct: 569 EVAEKQ-EATRQDHAQQLATAAEEREASLRERDAALKQLEA-LEKEKAAKLEILQQQLQV 626
Query: 732 ELKAR------LTQAQ---ASFEREREGLQSSAWT----EEKVRGLTQELE-QFHQEQLT 777
+AR +TQAQ A R+ E LQ+ T + + + ELE Q EQ
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 778 SLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCES 837
+ ++ ++++ +E L+ + L+ + +E E R +E Q Q+ ++
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ-----QRCISELKA 741
Query: 838 ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
+SL ++++E K+L+E++ K + Q+ EA + E L+RE ++
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGL-----EARLQQLGEAHQAETEVLRRELAEAMAA- 795
Query: 898 QEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSS---HKREL 954
+ T + +V E + ED + ++ +Q++ LK ++EL
Sbjct: 796 ------QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL 849
Query: 955 REREEVLC--QAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENIHKATCETADRE 1010
+E +E + ++ + Q++ Q+ E E+ + R Q++ K + + + T +
Sbjct: 850 QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD-DLSTLQEK 908
Query: 1011 RAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENG 1070
A S E++RL++ +++ + S +++ E GD +Q E L E+ G
Sbjct: 909 MAATSKEVARLETLVRKAGEQQETASR-----ELVKEPARAGD------RQPEWLEEQQG 957
Query: 1071 DVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTE 1130
S Q A + +E +M E+ RL+ L + + E G +
Sbjct: 958 RQFCSTQAALQAMEREAEQMGNELERLRAALMESQG----------QQQEERGQQEREVA 1007
Query: 1131 PFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEV---KIEESEASVEGFS 1187
Q+ Q + + ++LE L QE + E E + +
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA 1067
Query: 1188 ELENSEETRT-ESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1246
+L E + E EL+ + QL+EQL A ++K+ S + + R
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQLKEQL---------AKKEKEH----ASGSGAQSEAAGR 1114
Query: 1247 IPEASPKYKLLYEDVSR-ENDCL--QEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1303
PK + L +VS+ E C QE+ +E + + E + + LQ +L++
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174
Query: 1304 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQ--GKIEKLQESVVQRCDCCLWEASLENL 1361
+ L S + EL ++Q K E ++ V R EA +N
Sbjct: 1175 AQ------ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR---QEAERKNS 1225
Query: 1362 EIEP-DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAW--- 1417
I + + LN+ + E + + ++ +++Q LE +LL+ A A
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285
Query: 1418 ----LHGTIQT---HQERPRVQNQVILEENTT-----------LLGFQDKHFQHQATIAE 1459
L +Q+ E+ RV ++ + +E T+ L +Q+K FQ + ++
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345
Query: 1460 LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1519
L+LE T Q L V+ L+ K + + E+ H R
Sbjct: 1346 LQLEHTSTQAL-------VSELLPAKHLCQQLQAEQAAAEKRH----------------R 1382
Query: 1520 YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ---ENAAVQK 1576
E E+ +Q LR E+ E LG L ++++ ++ T +Q E A+ +
Sbjct: 1383 EELEQSKQAAGGLRAELLRAQRE-------LGELIPLRQKVAEQERTAQQLRAEKASYAE 1435
Query: 1577 MVENLKKQISELKIKNQQL--------DLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1628
+ LKK L +N+ L EL Q + ++L + L + +
Sbjct: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ 1495
Query: 1629 KEPGNSALE------EREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQEN 1682
+E ++A E + E K + EE +R + + L + +E Q + Q+E
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE--------QLEVFQREQ 1547
Query: 1683 HLLKDELEKMKQLHRCPDLSDFQQ-KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSL 1741
+EL K +L S QQ K+ +V + + +E + L +LN
Sbjct: 1548 TKQVEELSK--KLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ-------- 1597
Query: 1742 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE 1801
A + Q++++ EH + EK + D + N ++ L Q+E
Sbjct: 1598 -----AQLSQKEQAAEHYKLQM--------EKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
Query: 1802 KEALKQEVMSLHKQLQNAGGKS 1823
+ L+ E L +LQ AG K+
Sbjct: 1645 NKELRAEAERLGHELQQAGLKT 1666
Score = 157 bits (397), Expect = 1e-37
Identities = 299/1456 (20%), Positives = 594/1456 (40%), Gaps = 220/1456 (15%)
Query: 770 QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE--KMETECNRRTSQIEAQFQSD 827
QF +L + ++EL EL E + ++ + M+ +R E Q S
Sbjct: 213 QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASP 272
Query: 828 CQ-KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET- 885
+ K E +SL R + LK Q+ + EKSQ + + ++L++E + L+E
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDL-KTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 886 --LKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD---LEDLRNVSETQQSLLS 940
L++ + LT+E + + E + E LQD LE+ + + + S L
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391
Query: 941 DQILELKSSHKRELRE-----------REEVLCQAGASEQLASQRLERLEMEHDQERQEM 989
+ + +L+ + +E E ++E A + QL + R+E LE E Q+
Sbjct: 392 EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA-RVEMLETERGQQE--- 447
Query: 990 MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQA---------------TSP 1034
+KLLA E H + E+ ++S+ I+ LQS I + QA T+
Sbjct: 448 -AKLLA-ERGH------FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 1035 LSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE--QAVKENVKMAT 1092
++ L S + + D L+ L+Q Q E+ + +LQ+ + Q ++ V+ +
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQ--QAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
Query: 1093 EISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHV- 1149
S L+Q+ Q+L+ + + AE+ E L++ KQ+E + +
Sbjct: 558 --SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615
Query: 1150 -LSDLED-----DEVRDLGSTGTSSVQRQEV----KIEESEASVEGFSELENSEETRTES 1199
L L+ +E RD T + QR++ K+EE +A VE R E
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE---------TARQEQ 666
Query: 1200 WELKNQISQLQEQL---MMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
E + Q+++L+ QL + +R +++K L + LK+ LK+ + E
Sbjct: 667 HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE------- 719
Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
E+ R D L+E+ R + E E + V + + E K++EE LE
Sbjct: 720 --EEKRRAADALEEQQRCIS-------ELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770
Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESVVQRCD-----CCLWEASLENLEIEPDGNILQ 1371
++ ++ ++ R + Q + C+ W E+ + E
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830
Query: 1372 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI----QTHQE 1427
+ L ++E K++ +E +++L + +E+A LH + Q QE
Sbjct: 831 FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890
Query: 1428 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ--K 1485
+ V+ Q + ++ +TL Q +A E +L+ L RK E+ ++ K
Sbjct: 891 K-EVRAQKLADDLSTL----------QEKMAATSKEVARLETLVRKAGEQQETASRELVK 939
Query: 1486 DVLSHGEK-----EEELKAMMHDLQITCSEMQQKVELLRYESEKL-----------QQEN 1529
+ G++ EE+ Q M+++ E + E E+L Q+E
Sbjct: 940 EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999
Query: 1530 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET-VKQENAAVQKMVENLKKQISEL 1588
E+ L +E + L ++ E+ + + + ++ + E L ++E
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK 1059
Query: 1589 KIKNQQL-DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE----------------P 1631
+ K+Q+L L E +Q + E+L++ ++L E L +KEKE P
Sbjct: 1060 EGKDQELAKLRGLEAAQ--IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117
Query: 1632 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEK 1691
LE E L+++ ++ + Q+ +L SLEAE + + ++ L+++ ++
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177
Query: 1692 MKQLHRCPDLSDFQQKISS----VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA 1747
+ H L+ Q+++++ V +++ + K ++ K + S LE ++
Sbjct: 1178 LG--HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235
Query: 1748 TMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQ 1807
+ ++ E +S LK ++A EK Q LE+ ++ L + S+ + AL++
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR---LLQAETASNSARAAERSSALRE 1292
Query: 1808 EVMSLHKQL----------------QNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLM 1851
EV SL ++ Q + E+ +++ LS +L+H
Sbjct: 1293 EVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTS 1352
Query: 1852 NEE--QQLLWQENERLQTMVQNTKAELTHSRE--KVRQLESNLLPKHQKHLNPSGTMNPT 1907
+ +LL ++ Q + AE H E + +Q L + + G + P
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPL 1412
Query: 1908 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK--------QVKL 1959
Q+ +R Q + E++ Q++ L++ + EN GL ++ +V+L
Sbjct: 1413 RQKVAEQERTAQQLRAEKASY---AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469
Query: 1960 DEQ----LMEMQHLRSTATP-------SPSPHAWDLQLLQQQ----ACPMVPREQFLQLQ 2004
D+ + E+ +R+ A A +L+++ + ++ Q Q +
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529
Query: 2005 RQLLQAE--------RINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2056
RQ L A+ R EEL + ++++ Q+Q + ++ + E +Q+
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE---- 1585
Query: 2057 KRLLQEKVNQLKEQVS 2072
+ LQ ++N+L+ Q+S
Sbjct: 1586 AQRLQAQLNELQAQLS 1601
Score = 149 bits (377), Expect = 2e-35
Identities = 291/1470 (19%), Positives = 591/1470 (40%), Gaps = 174/1470 (11%)
Query: 368 LASFKAEIRHLLERVDQVVREKEKLRSD-LDKAEKLKSLMASEVDDHHAAIERRNEYNLR 426
L F + ++ L + ++++ E K + L+K +L+ +++ + D +E +NE
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC-LEEKNEILQG 385
Query: 427 KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 486
KL + +E ++ L++ +E+ ++L Q L+QE ++ R+ + E
Sbjct: 386 KLSQ-LEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQLQARVEMLETER 443
Query: 487 SRLENELLENA----EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM 542
+ E +LL E+ + +L LQ ++ N L++ +L+ +S RLT
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN-LSQAKEELEQASQA---HGARLTAQ 499
Query: 543 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 602
+ L + + EL + Q + + L + ++ +A+ G L S
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559
Query: 603 ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYE---KQLD----ETVVSCKK 655
E E ++ H + + E E +R + KQL+ E +
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619
Query: 656 AQENMKQRHE------NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQ 709
Q+ ++ +E +++ ++L ++ ELQ ++ HEA + E + Q
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679
Query: 710 L---QVKLEEEKTHLQEKLRLQHEME-LKARLTQAQASFEREREGLQSSAWTEEKVRGLT 765
L Q K E++ QEK +LQ +++ LK L + S E E+ +++ EE+ R ++
Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR--RAADALEEQQRCIS 737
Query: 766 QELEQFHQEQLTSLVEKHTLEKEELRKEL-----LEKHQRELQEGREKMETECNRRTSQI 820
+ + + SLVE+H E++EL +E LE ++L E + ETE RR
Sbjct: 738 EL-----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA-ETEVLRREL-- 789
Query: 821 EAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 880
A+ + CE ++ + +R+ +D Q+++ + + ++ + L +EC +A++
Sbjct: 790 -AEAMAAQHTAESECEQLVKEVAA-WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQ 847
Query: 881 LLKETLKR----EKTTSLVLTQEREMLEKTYK------EHLNSMVVERQQLLQDLEDLRN 930
L+E ++ E + L +++++ L + + + + V Q+L DL L+
Sbjct: 848 ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907
Query: 931 -VSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-----------------SEQLAS 972
++ T + + + L K+ ++E RE V A A S Q A
Sbjct: 908 KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967
Query: 973 QRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1032
Q +ER + E + + + L+ + + +RE A ++ E R Q+ + + A
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 1033 SPLSM-LQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMA 1091
+ L M LQ+ + E+ VE L E L L+ +KE ++
Sbjct: 1028 AELEMRLQNA---LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
Query: 1092 TEISRLQQRLQKLEPGLVMSSCLDEPA---TEFFG---------------------NTAE 1127
+ +L+++L K E S A TE G A+
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
Query: 1128 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1187
E L+ R + E + L +++ ++LG + ++ Q ++ V+ S
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR-ELAAFRTKVQDHS 1203
Query: 1188 ELENSEET-----RTESWELKNQISQLQEQLMMLCADC-DRASEKKQDLLFDVSVLKKKL 1241
+ E+ + R E+ + IS L+E++ +L ++ E K+ ++ +K
Sbjct: 1204 KAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
Query: 1242 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE---ALEN-NKELTAEVFRLQ 1297
K+ ER+ + + + L+EE++ + ++ A EN +ELT++ R +
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
+ ++++ E F E++ +++E+ LV L Q+ +Q +
Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ--LQAEQAAAEKRH 1381
Query: 1358 LENLEIEPDG------NILQLNQTLEECVP---RVRSVHHVIEECKQENQYLEGNTQLLE 1408
E LE +L+ + L E +P +V ++ + E +L+
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
Query: 1409 KVKAHEIAWLHGTIQTHQ----ERPRVQNQVILEENTTLLGFQDKHFQHQATI------- 1457
K HG + ER + Q + E L ++K+ Q A +
Sbjct: 1442 KA--------HGLLAEENRGLGERANLGRQFLEVE---LDQAREKYVQELAAVRADAETR 1490
Query: 1458 -AELELEKT----KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQ 1512
AE++ E +L+ +T K + +++++ E+ ++L A + L++ E
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ--EERQKLTAQVEQLEVFQREQT 1548
Query: 1513 QKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1572
++VE L + Q + + + ++ + + S + L E+ + +Q
Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE 1608
Query: 1573 AVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG 1632
+ +E K K +NQ+L + L Q +N+E L+ +RL
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE-LRAEAERLG----------- 1656
Query: 1633 NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV---QQENHLLKD-E 1688
E +Q KE + C+ + V SLEA+++ Q + Q LK E
Sbjct: 1657 ----HELQQAGLKTKEAEQTCR-HLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711
Query: 1689 LEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1718
+ QL D D + + LS KL
Sbjct: 1712 PQAKPQLDLSIDSLDLSCEEGTPLSITSKL 1741
Score = 99.0 bits (245), Expect = 4e-20
Identities = 201/982 (20%), Positives = 388/982 (39%), Gaps = 151/982 (15%)
Query: 1125 TAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR--------QEVKI 1176
T + + + Q R ++ + + S LE E+ +L S R Q++K
Sbjct: 245 TEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKT 304
Query: 1177 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1236
E+S+ + E + + + E + + QLQ+ L L + +A+++
Sbjct: 305 EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEW--------- 355
Query: 1237 LKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR- 1295
L+K+ ++ + + A K L E +N+ LQ +L +E + +N + EV
Sbjct: 356 LEKQAQLEKELSAALQDKKCLEE----KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGD 411
Query: 1296 -LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLW 1354
LQ E K E T L +LQ ++E L+ Q+
Sbjct: 412 VLQLETLKQEAAT-------------------LAANNTQLQARVEMLETERGQQ------ 446
Query: 1355 EASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE 1414
EA L + G+ + Q L + ++S + + K+E LE+
Sbjct: 447 EAKL----LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEE----------LEQASQAH 492
Query: 1415 IAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKL 1474
A L + + N I +++ L G + + + QA +A+ ++ + + R
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 1475 KERVTILVKQKDV-LSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES-----EKLQQE 1528
E+++ +KQK+ L +++E H Q+ + +++ L ++ E L++E
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 1529 NS----ILRNEITTLNEEDSISNLKL-------GTLNGSQEEMWQKTETVKQENAAVQKM 1577
+ IL+ ++ NE + + L+ EE+ ET +QE Q
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 1578 VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL--TEMLCQKEKEPGNSA 1635
V L+ Q+ QQ E ++Q+ Q QE+LQ L + L T+ ++EK A
Sbjct: 673 VAELELQLRS----EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
Query: 1636 LEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1695
LEE+++ LK E Q LE E + K +QQ + E E +++
Sbjct: 729 LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR- 787
Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAK-SSLLEHRIATMKQEQK 1754
+L++ + S E+L+KE A E + A+ ++ + ++ T+K+E +
Sbjct: 788 ----ELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843
Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
+ +L ++EKV +E + LQ+SR +++L Q+V
Sbjct: 844 K-------ARQELQEAKEKVAGIES---HSELQISRQQNELAELHANLARALQQVQEKEV 893
Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT-K 1873
+ Q A +++T + E+ +E RL+T+V+ +
Sbjct: 894 RAQKL-----ADDLST--------------------LQEKMAATSKEVARLETLVRKAGE 928
Query: 1874 AELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVS 1933
+ T SRE V++ +G P E+ ++ C Q R+
Sbjct: 929 QQETASRELVKEPAR------------AGDRQPEWLEEQQGRQFCST-QAALQAMEREAE 975
Query: 1934 QMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACP 1993
QM + + L +E++G ++Q + +Q E+ L + + DL L +
Sbjct: 976 QMGNELERLRAALMESQG--QQQEERGQQEREVARLTQERGRAQA----DLALEKAARA- 1028
Query: 1994 MVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKL 2053
E ++LQ L + LQE L + +E +L + ++ E+E+
Sbjct: 1029 ----ELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
Query: 2054 KLVKRLLQEKVNQLKEQVSLPG 2075
+ VK+L ++ + KE S G
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSG 1106
Score = 81.6 bits (200), Expect = 7e-15
Identities = 168/824 (20%), Positives = 335/824 (40%), Gaps = 103/824 (12%)
Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV------HHVIEECKQE 1396
E+V+Q DC ++ ++ + +G + L Q + E + V S H EC
Sbjct: 25 EAVLQLQDCSIFIKIIDRIHGTEEGQQI-LKQPVSERLDFVCSFLQKNRKHPSSPECLVS 83
Query: 1397 NQ-YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE-ENTTLLGFQDKHFQHQ 1454
Q LEG+ LE K + H T+ + R Q + ++ E +L F H
Sbjct: 84 AQKVLEGSE--LELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGL 141
Query: 1455 ATIAELE--LEKT------------KLQELTRKLKERVTILVKQKDVLSH-------GEK 1493
+LE L+K +L + + K + L QK S G
Sbjct: 142 NLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSP 201
Query: 1494 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1553
+ ++ Q +++++ R ++L+ E + R +T + + ++ ++ L
Sbjct: 202 ASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL 261
Query: 1554 NGSQEEMW------QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
E+ ++ E ++ +N ++ + KQ +LK + Q+D + +LS++N
Sbjct: 262 ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321
Query: 1608 QNQEKLQELNQRLTEM--LCQKEKEPGNSALEEREQEKFNLKEEL------ERCKVQSST 1659
KL+E L ++ + E + A +E +++ L++EL ++C + +
Sbjct: 322 DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381
Query: 1660 L----VSSLEAELSEVKIQTHIVQQENHLLKD--ELEKMKQLHRCPDLSDFQQKISSVLS 1713
+ +S LE LS+ +Q + Q++ +L D +LE +KQ ++ Q + +
Sbjct: 382 ILQGKLSQLEEHLSQ--LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439
Query: 1714 YNEKLLKEKEALSEELNSCVDKLAKSSL---LEHRIATMKQ-----EQKSWEH------Q 1759
E+ +E + L+E + +K SSL L+ I+ + Q EQ S H Q
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 1760 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE---------------A 1804
ASL S+L +Q + + + Q ++ L T Q++E +
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559
Query: 1805 LKQEVMSLHK--QLQNAGGKSWAPEIAT----------HPSGLHNQQKRLSWDKLDHL-- 1850
LKQ+ L + + Q A + A ++AT Q + L +K L
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619
Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
+ ++ Q+ + + QT V + E KV +L++ + Q+ + E +
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679
Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQV-KLDEQLMEMQHL 1969
S +++ + ++ ++ Q+ +L++ L+ E K++ L+EQ + L
Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739
Query: 1970 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2029
++ H + + L+++ E LQ + QAE + L+ EL + +
Sbjct: 740 KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE--TEVLRRELAEAMAAQH 797
Query: 2030 TPQGNQEQL---VTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
T + EQL V ER + +Q+ + QE++ LKE+
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE 841
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 157 bits (397), Expect = 1e-37
Identities = 241/1117 (21%), Positives = 485/1117 (43%), Gaps = 191/1117 (17%)
Query: 343 INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLD-KAEK 401
+ + E LA EN L T+ Q+ L + K +++ L+ ++ E E+LR+ L K ++
Sbjct: 855 VKVREKQLAAENRL--TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912
Query: 402 LKSLMASEVDDHHAAIERRNE--YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 459
L+ + D A +E E +L+ ++ ++ I L+ +L +E E Q+ +++
Sbjct: 913 LEEIC----HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE-ESARQKLQLEKV 967
Query: 460 ELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 519
E +++K + E+ + D+ KE LE+ + E L E E + L + L+N
Sbjct: 968 TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-LKNKHE 1026
Query: 520 EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQ----GRVLR 575
DL+ Q + L + R + E L DQ+ ELQ+++ E + Q L+
Sbjct: 1027 AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 576 LPLKNSPSEEVEAN----------SGGIEPEHGLGSEECN-------------------- 605
L E + N S E + L SE +
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 606 PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
L ++++ ++++ + +++ L+ LE++ + +E Q+ E +A E + ++ E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 666 NETHT---LEKQISDLKNEIAELQGQAAVLKEAHHEATCRH---EEEKKQLQVKLEEE-- 717
LEK L+NE EL + VL + ++ + E + ++LQVK E
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 718 -KTHLQEKL-RLQHEME-----------LKARLTQAQASFEREREGLQSSAWTEEKVR-G 763
+T L +K+ +LQ E++ ++LT+ ++ E + + Q E + +
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 764 LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH----QRELQEGREKMETE--CNRRT 817
L+ +L+Q E+ + + LE+EE K LEK ++ + ++KME C
Sbjct: 1327 LSTKLKQVEDEKNSF---REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 1383
Query: 818 SQIEAQFQSDCQKVTERCESA------LQSLEGRYRQELKDLQ---EQQRE-----EKSQ 863
+++ + Q D + +++R E L+ + R +QEL DL + QR+ EK Q
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 864 WEF-----EKDELTQECAEAQELLKETLKREKTTSLVLTQ----------EREMLEKTY- 907
+F E+ ++ + AE ++ + + ++T +L L + E E L K +
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 908 -----------------------KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL 944
K L V E + L++LED +E + L +
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 945 ELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH---- 1000
+K+ +R+L+ R+E Q+ ++ +++ +E E + ER++ + A + +
Sbjct: 1564 AMKAQFERDLQGRDE---QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 1001 --KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSL 1058
+A ++A++ R E ++ +LQ+++K+ + + +++ + + S+
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE--EILAQAKENEKKLKSM 1678
Query: 1059 LQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQ-------QRLQKLEPGLVMS 1111
+ QL EE L + +RA QA +E ++A EI+ + ++LE +
Sbjct: 1679 EAEMIQLQEE----LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ- 1733
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ- 1170
L+E E GNT L +R K+ ++L+ D++ + S Q
Sbjct: 1734 --LEEELEEEQGNTE------LINDRLKK----------ANLQIDQINTDLNLERSHAQK 1775
Query: 1171 ----RQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLMMLCADCDRAS 1224
RQ+++ + E V+ E+E + +++ ++ L+ +I+QL+EQL D +
Sbjct: 1776 NENARQQLERQNKELKVK-LQEMEGTVKSKYKASITALEAKIAQLEEQL-------DNET 1827
Query: 1225 EKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALE 1284
+++Q V +KKLK + + + Y+D + D L+ ++ + +EA E
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD---QADKASTRLKQLKRQLEEAEE 1884
Query: 1285 NNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1321
+ A +LQ EL E+ TET ++ + +K
Sbjct: 1885 EAQRANASRRKLQREL---EDATETADAMNREVSSLK 1918
Score = 153 bits (386), Expect = 2e-36
Identities = 241/1117 (21%), Positives = 472/1117 (42%), Gaps = 202/1117 (18%)
Query: 433 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
+E + A + EL K RE+ Q A + RL + ++ E L L+E + E E
Sbjct: 844 EEEMMAKEEELVKVREK--QLAAENRLTEMETLQSQLMAEK-------LQLQEQLQAETE 894
Query: 493 LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
L AE+L LT K Q L E DL+ E +EER ++ E ++
Sbjct: 895 LCAEAEELRA--RLTAKKQE-----LEEICHDLEARVEE---EEERCQHLQAEKKK---- 940
Query: 553 LQDQVDELQSELEEYRAQGRVLRLP-------LKNSPSEEV--EANSGGIEPEHGLGSEE 603
+Q + EL+ +LEE + + L+L LK E++ E + + E L +
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 604 CNPLNMSI----EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 659
++ E + ++K +H I +LE+++R EKQ E E
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMIT----DLEERLRREEKQRQEL--------EK 1048
Query: 660 MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV------K 713
+++ E ++ L QI++L+ +IAEL+ Q A +E A R EEE Q + +
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 714 LEEEKTHLQEKLRLQHEM-------------ELKARLTQAQASFEREREGLQSSAWTEEK 760
LE + + LQE L + EL+A T+ + + + + + E++
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 761 VRGLTQELEQ---FHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETECNR 815
V L + LE+ H+ Q+ + +KH+ EEL ++L ++ + L++ ++ +E E
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 816 RTSQIEA--QFQSDCQKVTERCESALQSLE------GRYRQELKD--------------L 853
++++ Q + D + ++ E+ LQ L+ R R EL D L
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 854 QEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNS 913
Q + S+ + L + + QELL+E +++ + S L Q + + +++E L
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE-KNSFREQLEE 1347
Query: 914 MVVERQQLLQDLEDLRNVSETQQSLLSDQI--LELKSSHKRELREREEVLCQAGASEQLA 971
+ L + + L + + D + LE KR+L++ E L Q + A
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407
Query: 972 SQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER-------------AEMSTEI 1018
+LE+ + QE ++ L+ +++ ++ C +++ A+ + E
Sbjct: 1408 YDKLEKTKTRLQQELDDL---LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 1019 SRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQ-----QGEQLLEENGDV- 1072
R +++ +E + T LS+ ++ EE +E L L + E L+ DV
Sbjct: 1465 DRAEAEAREKE--TKALSLARA-----LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517
Query: 1073 -----LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE 1127
L +RA EQ V+E M T++ L+ LQ E + + F +
Sbjct: 1518 KSVHELEKSKRALEQQVEE---MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574
Query: 1128 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1187
+ ++ + + V V R + ++LED+ R S ++ ++ E+ +++ EA
Sbjct: 1575 GRDEQSEEKKKQLVRQV--REMEAELEDE--RKQRSMAVAARKKLEMDLKDLEA------ 1624
Query: 1188 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-- 1245
++++ + R E+ + Q+ +LQ Q+ + D ++++L +KKLK +E
Sbjct: 1625 HIDSANKNRDEAIK---QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681
Query: 1246 --RIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1303
++ E + +E D L +E+ + ALE + L A + +L++EL++
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 1304 EEVTE-----------------TFLSLEKSY--------DEVKIENEELNVLVLRLQGKI 1338
+ TE T L+LE+S+ +++ +N+EL V + ++G +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801
Query: 1339 -------------------EKLQESVVQRCDCC----LWEASLENLEIEPDG---NILQL 1372
E+L +R C E L+++ ++ D N Q
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Query: 1373 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK 1409
++ R++ + +EE ++E Q + + L++
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898
Score = 141 bits (355), Expect = 8e-33
Identities = 230/1020 (22%), Positives = 447/1020 (43%), Gaps = 181/1020 (17%)
Query: 313 VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 372
+E++ + + +E Q IL+ + L L E +A E +T+ +LA K
Sbjct: 964 LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA-EFTTNLTEEEEKSKSLAKLK 1022
Query: 373 AEIRHLLERVDQVVREKEKLRSDLDKAEK----------------------LKSLMASEV 410
+ ++ +++ +R +EK R +L+K + LK +A +
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082
Query: 411 DDHHAAIERRNE------YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQE 464
++ AA+ R E L+K+ E + +I+ L+ +L ER +A KQ+ +L +E
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERAS-RNKAEKQKRDLGEE 1140
Query: 465 IEKAKTEENYIRDRLALSLKENSRLENEL-------------------------LENAEK 499
+E KTE D A + S+ E E+ + E+
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200
Query: 500 LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 559
LAE T +++ NLE L+ E + + L Q + + E + + ++ Q+ E
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQ----TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256
Query: 560 LQSELEEYRAQGRVLRLPLKNSPSE-EVEA-NSGGIEPEHGLGSEECNPLNMSIEAELV- 616
LQ + E G +R L + ++ +VE N G+ + S + ++E++L
Sbjct: 1257 LQVKFNE----GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 617 IEQMKEQHHRDICCLRLEL---EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEK 673
+++ ++ +R L +L ED+ + +QL+E +E K E + TL
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE--------EEEAKHNLEKQIATLHA 1364
Query: 674 QISDLKNEIAELQGQAAVLKEAHH------EATCRHEEEKKQLQVKLEEEKTHLQEKL-- 725
Q++D+K ++ + G +E E + EEK KLE+ KT LQ++L
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 726 ---RLQHEMELKARLTQAQASFER--------------EREGLQSSAWTEE-KVRGLTQE 767
L H+ + L + Q F++ ER+ ++ A +E K L +
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Query: 768 LEQFHQE--QLTSLVEKHTLEKEEL--RKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
LE+ ++ +L L ++ E E+L K+ + K EL++ + +E + +Q+E +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-E 1543
Query: 824 FQSDCQKVTE---RCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 880
+ + Q + R E LQ+++ ++ ++L+ EQ E+K Q L ++ E +
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ-------LVRQVREMEA 1596
Query: 881 LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLS 940
L++ +++++ ++ ++ EM K + H++S R + ++ L L Q+ +
Sbjct: 1597 ELEDE-RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-------QAQMK 1648
Query: 941 DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 1000
D + EL + REE+L QA +E ++L+ +E E Q ++E L A E
Sbjct: 1649 DCMRELDDTR----ASREEILAQAKENE----KKLKSMEAEMIQLQEE----LAAAERAK 1696
Query: 1001 KATCETADRERAEMSTEISRLQSK----IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1056
+ A +ER E++ EI+ K ++E ++ + ++ L+ EE +G+ L
Sbjct: 1697 R----QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL-----EEEQGNTEL 1747
Query: 1057 ---SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQRLQKLEPGLVMS 1111
L + Q+ + N D L+L+R+H Q EN + E L+ +LQ++E G V S
Sbjct: 1748 INDRLKKANLQIDQINTD--LNLERSHAQK-NENARQQLERQNKELKVKLQEME-GTVKS 1803
Query: 1112 ------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR--RHVLSDLEDD------- 1156
+ L+ + +T+ +Q KQV + + VL ++D+
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKE--RQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Query: 1157 -EVRDLGSTGTSSVQRQ-EVKIEESEASVEGFSELENSEETRTESWELKN-QISQLQEQL 1213
+ D ST ++RQ E EE++ + +L+ E TE+ + N ++S L+ +L
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 113 bits (282), Expect = 2e-24
Identities = 253/1270 (19%), Positives = 499/1270 (39%), Gaps = 248/1270 (19%)
Query: 873 QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 932
Q C K KR++ + + ++L++ +L + +L ++ L VS
Sbjct: 787 QACCRGYLARKAFAKRQQQLTAM-----KVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVS 841
Query: 933 ETQQSLLSDQ-----ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 987
++ +++ + + E + + + L E E + Q A E+L Q + E E E +
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAE 900
Query: 988 EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML----QSGCQ 1043
E+ ++L A + + C + E LQ++ K+MQQ L +S Q
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960
Query: 1044 VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1103
+ E+V + L L++ + +LE+ +N K+A E L+ R+
Sbjct: 961 KLQLEKVTTEAKLKKLEEEQIILED-----------------QNCKLAKEKKLLEDRI-- 1001
Query: 1104 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDL 1161
EF N E+ E ++K + + +H +++DLE+ R+
Sbjct: 1002 ---------------AEFTTNLTEEEE------KSKSLAKLKNKHEAMITDLEERLRRE- 1039
Query: 1162 GSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCD 1221
++Q ++E++ +EG +S +L +QI++LQ Q+ L
Sbjct: 1040 --------EKQRQELEKTRRKLEG------------DSTDLSDQIAELQAQIAELKMQLA 1079
Query: 1222 RASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
+ E+ Q L V + M A K + L +S LQE+L ++
Sbjct: 1080 KKEEELQAALARVEEEAAQKNM------ALKKIRELESQISE----LQEDLESERASRNK 1129
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKL 1341
A + ++L E+ L+ EL+ + T L ++ E+N+L L+ + +
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ------EVNILKKTLEEEAKT- 1182
Query: 1342 QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLE 1401
EA ++ + + + +L + LE+ + V +E+ KQ +
Sbjct: 1183 ------------HEAQIQEMRQKHSQAVEELAEQLEQ----TKRVKANLEKAKQTLENER 1226
Query: 1402 GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELE 1461
G +L +VK L G + +R +V+ Q L Q K + + EL
Sbjct: 1227 G--ELANEVKV----LLQGKGDSEHKRKKVEAQ--------LQELQVKFNEGERVRTELA 1272
Query: 1462 LEKTKLQ-ELTRKLKERVTILVKQKDVLSHGEKEE--ELKAMMHDLQITCSEMQQKVELL 1518
+ TKLQ EL + VT L+ Q D S ++ L++ + D Q E ++ L
Sbjct: 1273 DKVTKLQVEL-----DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNLK--LGTLNGSQEEMWQKTE-------TVKQ 1569
+ ++++ E + R ++ EE++ NL+ + TL+ +M +K E T ++
Sbjct: 1328 STKLKQVEDEKNSFREQLE--EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 1570 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQK----------NSQNQEKLQELNQR 1619
+QK +E L ++ E +L+ T L Q+ Q+ L++ ++
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 1620 LTEMLCQ-------------------KEKEPGNSALEEREQEKFNLKEELERCKVQSSTL 1660
++L + +EKE +L +E K ELER Q T
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 1661 VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLK 1720
+ L + +V H +++ L+ ++E+MK
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK--------------------------T 1539
Query: 1721 EKEALSEELNSCVD-KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLED 1779
+ E L +EL + D KL L+ A +++ + + QS K QLV +V+ +E
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV---RQVREMEA 1596
Query: 1780 TVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQ 1839
+++ Q S + + + + + L+ + S +K E L Q
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN---------RDEAIKQLRKLQAQM 1647
Query: 1840 KRLSWDKLDHLMNEEQQLLWQ--ENER----LQTMVQNTKAELTHSREKVRQLESNLLPK 1893
K +LD +++L Q ENE+ ++ + + EL + RQ +
Sbjct: 1648 KD-CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Query: 1894 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK 1953
+ N SG +EK L+ Q ++E LE+E L N+ LK
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEE-------------LEEEQGNTELINDRLK 1753
Query: 1954 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ------LQRQL 2007
K +++D+ ++ RS A + + Q L++Q + + Q ++ + +
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENAR----QQLERQNKELKVKLQEMEGTVKSKYKASI 1809
Query: 2008 LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQE----- 2062
E L+E+L+N T E + +++ +++V+ + + ++ +
Sbjct: 1810 TALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869
Query: 2063 -KVNQLKEQV 2071
++ QLK Q+
Sbjct: 1870 TRLKQLKRQL 1879
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 157 bits (396), Expect = 1e-37
Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)
Query: 760 KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
KV+ L Q Q + Q ++ L+K + R++ E +EL++ ++ E N Q
Sbjct: 840 KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 820 IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 877
++A+ + ++ +++ R + Q LE E++ E++ + Q + E+ ++ Q+ +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 878 AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 930
+E L+E L+ EK T+ ++ E + N + ER+ L + + DL N
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 931 VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 990
++E ++ + + +LK+ H+ + E E L E+ + Q LE+L+ + + + +
Sbjct: 1015 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 991 SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1049
++ ++ I + + A +E E+ ++RL +I + A + L+ I + +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1124
Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
+ D + + E+ + G+ L +L+ E + ++ + R ++ + V
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1178
Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1162
+ LDE E + Q + T+Q+E R D LE + G
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 1163 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
+QEV K ++ EA V+ S+ + E R EL +++ +LQ ++ +
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1295
Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1279
+ A K L DV+ L +L+ + + + + KL +VS + L+EE ++ +
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1352
Query: 1280 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1332
DE +E + L + +L D KK+++ T +LE+ + E E L
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1390
K+EK + + Q D + L+N + + N+ + + ++ + +++ +
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1449
E + E + E T+ L +A E A ++ +E R N+++ E L+ +D
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1523
Query: 1450 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1490
+A ++E KT+L+EL T K R+ + ++ ++D+ +
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 1491 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1544
E+ EE L+ +H+ + + +++ L +KL+ + + L+ + E++
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643
Query: 1545 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
I L+ L S++E++ + +++ +++ + L++ ++ +
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 1593 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1649
+Q DLE EL+++ + + LQ+ +RL + Q E+E LEE + + +
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1758
Query: 1650 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1703
+ + Q+ L + L E S + QQ +N L+ +L +M+ + ++
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
+ KI+ + E+ +EK+A ++ L DK K LL+ + ++ + ++ Q+
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1875
Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
+++ + +++ E+ Q +N +++ +L + EA+ +EV +L +L+ S
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935
Query: 1824 WAP 1826
+ P
Sbjct: 1936 FVP 1938
Score = 149 bits (377), Expect = 2e-35
Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)
Query: 433 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
+E + A ++EL+K +E+ Q+A + ELEQ+ + E+N ++++L + + E
Sbjct: 851 EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 493 LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
+ A K E E + ++++ LE +E+R Q++ E ++ +
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 951
Query: 553 LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 612
+ D L+ +LEE A + L+L + EA +E E + ++ N L+
Sbjct: 952 MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1000
Query: 613 AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 659
++ E+ D+ E E+K ++ +E + E V KK + E
Sbjct: 1001 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 660 MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
+K++ E + +QI+DL+ +IAEL+ Q A +E A R ++E Q K
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1107
Query: 720 HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
+ +K+R EL+ ++ Q + ER + E++ R L +ELE E
Sbjct: 1108 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1155
Query: 780 VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 839
+ TL+ ++EL K ++E+ ++ ++ E +Q++ Q Q V E E
Sbjct: 1156 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1212
Query: 840 QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 899
++ K + + K E E +L E + +E ++K Q
Sbjct: 1213 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1261
Query: 900 REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 954
+E+ K + LN V + Q ++ + + N +E + L+ + L S +L
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1317
Query: 955 REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1014
++ +E+L + + S +L +LE E + + ++ ++ A +N+ + +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1366
Query: 1015 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074
ST +L K++Q S + L+ G + ++E+E +L QQ EE
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1416
Query: 1075 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1134
L++ + +E + ++ +Q + LE L A++ +
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1135 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
+ R K+ + ++ L + LE E +L T E + + + ELE S+
Sbjct: 1477 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 1194 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1244
T+ E+K Q+ +L+++L L + + + K Q DL ++K + L
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 1245 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1297
+R +Y+ ED ++ L+ +L+ +E + D A++ +E ++ +LQ
Sbjct: 1595 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651
Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
++K + E S DE+ +E L+ + +LQE + + +A
Sbjct: 1652 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1707
Query: 1358 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1411
LE E+ E + L L++ R+ + + + EE ++E +E + + K
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 1412 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
++E+A T Q ++ ++ QN+ + + + G F ++TIA LE + +
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1825
Query: 1467 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1514
L+E + K+ T +KQKD +L E E E+ K +++++
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 1515 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1574
+E ES+++ L+ E+ E + ++ L S+ +T V +
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1944
Query: 1575 QKMVENLKKQISELKIKNQQLDLENTELSQ 1604
++++EN SE + + D T+ S+
Sbjct: 1945 RRVIENADG--SEEETDTRDADFNGTKASE 1972
Score = 148 bits (374), Expect = 5e-35
Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)
Query: 351 ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
A E+EL TK +A + E++ L ++ Q+ EK L+ L +L + A E+
Sbjct: 856 AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 909
Query: 411 DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 459
AA ++ E L +++ EE ++R L+ E +K +Q+L ++A +Q+L
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 460 ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 508
+LE+ +AK ++ + D + + +N++L E +LLE AE+ + +NLT
Sbjct: 970 QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1026
Query: 509 KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 564
KL+ E++++E + + S E + +L +++ Q LQ Q+ EL+ +L
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 565 -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 604
+E Q + RL KN+ +++ G I + + L SE
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 605 ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
L ++++ ++++ + +++ L+ L+++ R +E Q+ E +A E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 659 NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
+ ++ E L+K L+ E A+L G+ VL +A E E +KK+L+ +++
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1262
Query: 716 E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 753
E + L +K+ +LQ+E+E + L +A+ AS + + Q
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322
Query: 754 SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
E + + ++ +L Q +E+ SL ++ L++E K+ LE+H L + +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 813 CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 857
S +EA +FQ + + +T++ E L+ + R +QEL DL + Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 858 RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 895
R+ EK Q +F++ DE + AEA+E KET L R +L
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1497
Query: 896 LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
+E E K K + +V + + + +LE + ETQ + Q+ EL+
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1553
Query: 953 ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
EL+ E+ + + Q + ER D++ +E +L + ++ E ++RA
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613
Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
+ +L+ +K+++ LQ+ + G EE ++Q +L + D
Sbjct: 1614 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1657
Query: 1073 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1117
L+ A KEN K A ++ +LQ+ L E L +E
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 1118 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1166
A+ G A Q E + R Q +E ++ R + + +++ + +T
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 1167 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1220
S+ Q+ E ++ E + E+E + +++ +S L+ +I+QL+EQ+ +
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 1221 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1269
A+ +K + L + ++ + KM E+ E + K K E+ E+ +
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 1270 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1326
R ++ DEA E+N+ + EV L+ +L++ E +F+ +S IEN +
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1952
Score = 139 bits (351), Expect = 2e-32
Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)
Query: 560 LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 619
LQ +E Q + L ++ E +E +H +EE N L ++AE +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 620 MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 679
E+ + + ELE+ + E +L+E +E+ Q+ + E + +Q+ DL+
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 956
Query: 680 NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 739
++ E + L+ A + ++ + ++ V ++++ L ++ +L L+ R++
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1010
Query: 740 AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
+ E EEK + LT +L+ H+ ++ L + L+KEE ++ LEK +
Sbjct: 1011 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1057
Query: 800 RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
R+L+ + +QI A+ + K E ++AL L+ Q+ L++ +
Sbjct: 1058 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116
Query: 860 EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 917
E + ++D ++ A + E KR+ L +E E L+ ++ L+S +
Sbjct: 1117 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1167
Query: 918 -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 976
R + Q++ L+ + + Q+ E++ H + + E E L Q ++ + +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 977 RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
LE E+ QE + KL A ++ C +R RAE++ ++ +LQ+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Query: 1024 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1068
+ IK + S S LQ +++ EE + + L+Q E+ E
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1345
Query: 1069 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
N L Q E K+N++ ++T +L +KL+ L+E F
Sbjct: 1346 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1184
T+ + ++ T+ + +L DD V DL + S++++++ K ++ A +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
S E R E+ + + + + + L + A E K++L +LK +++ L
Sbjct: 1462 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 1245 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1304
S K +DV + L++ R +ET+ +E +EL E+ +D ++E
Sbjct: 1517 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 1305 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1358
+ E+ +NEE + R + E +L++ QR E L
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626
Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1418
++LE++ D I + EE + ++R + +++ ++E LE +A +
Sbjct: 1627 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1671
Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1477
T + ++++ + L+ Q+ + + +LEK +L +EL L R
Sbjct: 1672 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 1478 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
+ +++ L+A + L+ E Q +E + K Q+ L NE+
Sbjct: 1725 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
T + L +E+ K + E A K K I+ L+ K QL+
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1828
Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1652
+ + +++ + L++ +++L E+L Q E E + + + EK N LK +LE
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 1653 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1691
+ +S + ++ L+ EL E + +E + LK +L +
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 110 bits (276), Expect = 1e-23
Identities = 221/1124 (19%), Positives = 459/1124 (40%), Gaps = 145/1124 (12%)
Query: 1020 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1076
RL +K+K + Q T +Q+ Q E + + + L L+Q L E ++L
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 1077 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1136
+A + E +M ++ +Q L+++ M + L+E +++
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 936
Query: 1137 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1196
R +Q++ ++ L+ +E + +Q ++V E +E + + + +
Sbjct: 937 RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996
Query: 1197 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
L + L+E++ L + EK ++L KLK + + +L
Sbjct: 997 -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1043
Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
E+ SR+ L++ R +E + E +L A++ L+ +L K EE E +L +
Sbjct: 1044 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1099
Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
DE+ +N L + L+G I LQE + +R E +L E + +L T
Sbjct: 1100 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1435
L+ + K+E + L E+ ++HE + R ++
Sbjct: 1159 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1203
Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
+EE T L Q + A L+ K L++ L + +L + K + H K++
Sbjct: 1204 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1255
Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1547
+L+A + +LQ CS+ ++ L + KLQ E N I + S+S+
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 1548 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
T QEE QK V + +++ +L+ Q+ E Q L+ + L+ + S
Sbjct: 1316 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 1608 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1654
+++KLQ+ Q+ E L Q+ +E +A ++ E+ K L++EL+
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1433
Query: 1655 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1707
V LVS+LE + + K + +++N K DE ++ + R + +
Sbjct: 1434 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
+ L E+L + + L E+ D ++ + + +++ +++ E Q +K+QL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1821
++++Q ED + + M +K DL+ ++ E ++++ LH+ + +
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 1822 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR- 1880
+ A L K L + E+ + ++ +LQ +++ + EL +R
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1666
Query: 1881 -------------EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQ 1920
+K + LE++L+ + + EK L E +
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726
Query: 1921 FQKEQSPANRKVSQMNS-LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1979
Q E+ +++Q+ LE+E + ++ ++K + ++ E+ RSTA + S
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 1980 HAWDLQLLQQQACPMVPREQFLQ------LQRQLLQAERINQHLQEELENRTSETNTPQG 2033
Q L++Q + + ++ + + E L+E++E E
Sbjct: 1787 R----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE------KVNQLKEQV 2071
+ +Q ++E +++VE + K+ ++ ++ +V QLK Q+
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Score = 106 bits (264), Expect = 3e-22
Identities = 210/977 (21%), Positives = 408/977 (41%), Gaps = 126/977 (12%)
Query: 1169 VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQ 1228
V RQE +++ E ++ E + E + EL+ + SQL E+ +L ++
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELK--ELEQKHSQLTEEKNLL----------QE 894
Query: 1229 DLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKE 1288
L + + + +M R+ A+ K +L E++ E + EE E R + K+
Sbjct: 895 QLQAETELYAEAEEMRVRL--AAKKQEL--EEILHEMEARLEE---EEDRGQQLQAERKK 947
Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG-KIEKLQESVVQ 1347
+ ++ L+++L++ EE L LEK E KI+ E +LV+ Q K+ K ++ + +
Sbjct: 948 MAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 1348 RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL 1407
R + E E N+ +L E +I E + + E + Q L
Sbjct: 1007 RISDLTTNLAEEE---EKAKNLTKLKNKHES----------MISELEVRLKKEEKSRQEL 1053
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-- 1465
EK+K L G E+ I E L K + QA +A L+ E
Sbjct: 1054 EKLKRK----LEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEIAQK 1106
Query: 1466 -----KLQELTRKLKERVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKV 1515
K++EL + + L ++ + EK+ EEL+A+ +L+ T +
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 1516 ELLRYESEKLQQENSILRNEIT--TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAA 1573
EL K +QE ++L+ + T + E + ++ + EE+ ++ E K+ A
Sbjct: 1167 EL----RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKAN 1221
Query: 1574 VQKMVENLKKQISEL--------------KIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
+ K + L+K+ ++L + K ++L+ + EL K S + ELN +
Sbjct: 1222 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE---VKIQTH 1676
+ ++ Q E E L E E + L +++ Q L+ E + V +
Sbjct: 1282 VHKL--QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 1677 IVQQENHLLKDELEKMKQLHRCPD---------LSDFQQKISSVLSYNEKLLKEKEALSE 1727
+++E + L+D+L++ + + + LSD ++K+ S E L + K+ +
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 1728 ELNSCVDKLAKSSLLEHRIATMKQE-QKSWEHQSASLKSQ--LVASQEKVQNLEDTVQNV 1784
E+ + + + + ++ K Q+ + L +Q LV++ EK Q D +
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 1785 NLQMSRMKSDLRVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
+S +D R + E EA ++E +SL + L+ A E+ L + + L
Sbjct: 1460 EKNISSKYADER-DRAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDL 1516
Query: 1843 SWDKLD-----HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP-KHQK 1896
K D H + + ++ L + E ++T ++ + EL + + +LE N+ K Q
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 1897 HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK----VSQMNSLEQELETIHLENEGL 1952
+ E+++ L+R+ +++ E ++ + LE +L+ + L+ +
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 1953 KK------KQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQR 2005
K KQ+ KL Q+ + Q A S + +++A + +QLQ
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQE 1694
Query: 2006 QLLQAERIN-------QHLQEELENRTSETNTPQGNQEQL---VTVMEERMIEVEQKLKL 2055
L AER + L EEL + S N Q + +L + +EE + E + ++
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 2056 VKRLLQEKVNQLKEQVS 2072
+ ++ K Q EQ+S
Sbjct: 1755 MSDRVR-KATQQAEQLS 1770
Score = 41.6 bits (96), Expect = 0.008
Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)
Query: 329 QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 386
+E+ + L SL G L + LE + + + Q + + +R ++ +Q+
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 387 REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 439
E RS K E + +ER+N+ KL E ++K IAAL
Sbjct: 1771 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819
Query: 440 KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 499
+ ++ + EQ+ Q+A + +Q K+ +++ + L +++ ++ + E AEK
Sbjct: 1820 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 500 LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 559
+L+R LE + + S +L + +E + +V+
Sbjct: 1875 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 560 LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
L+S+L R +P + S V N+ G E E
Sbjct: 1924 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1957
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 157 bits (396), Expect = 1e-37
Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)
Query: 760 KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
KV+ L Q Q + Q ++ L+K + R++ E +EL++ ++ E N Q
Sbjct: 847 KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 820 IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 877
++A+ + ++ +++ R + Q LE E++ E++ + Q + E+ ++ Q+ +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 878 AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 930
+E L+E L+ EK T+ ++ E + N + ER+ L + + DL N
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 931 VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 990
++E ++ + + +LK+ H+ + E E L E+ + Q LE+L+ + + + +
Sbjct: 1022 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 991 SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1049
++ ++ I + + A +E E+ ++RL +I + A + L+ I + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1131
Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
+ D + + E+ + G+ L +L+ E + ++ + R ++ + V
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1185
Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1162
+ LDE E + Q + T+Q+E R D LE + G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 1163 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
+QEV K ++ EA V+ S+ + E R EL +++ +LQ ++ +
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1302
Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1279
+ A K L DV+ L +L+ + + + + KL +VS + L+EE ++ +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1359
Query: 1280 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1332
DE +E + L + +L D KK+++ T +LE+ + E E L
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1390
K+EK + + Q D + L+N + + N+ + + ++ + +++ +
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1449
E + E + E T+ L +A E A ++ +E R N+++ E L+ +D
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1530
Query: 1450 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1490
+A ++E KT+L+EL T K R+ + ++ ++D+ +
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590
Query: 1491 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1544
E+ EE L+ +H+ + + +++ L +KL+ + + L+ + E++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 1545 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
I L+ L S++E++ + +++ +++ + L++ ++ +
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 1593 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1649
+Q DLE EL+++ + + LQ+ +RL + Q E+E LEE + + +
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1765
Query: 1650 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1703
+ + Q+ L + L E S + QQ +N L+ +L +M+ + ++
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
+ KI+ + E+ +EK+A ++ L DK K LL+ + ++ + ++ Q+
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1882
Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
+++ + +++ E+ Q +N +++ +L + EA+ +EV +L +L+ S
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942
Query: 1824 WAP 1826
+ P
Sbjct: 1943 FVP 1945
Score = 149 bits (377), Expect = 2e-35
Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)
Query: 433 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
+E + A ++EL+K +E+ Q+A + ELEQ+ + E+N ++++L + + E
Sbjct: 858 EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 493 LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
+ A K E E + ++++ LE +E+R Q++ E ++ +
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 958
Query: 553 LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 612
+ D L+ +LEE A + L+L + EA +E E + ++ N L+
Sbjct: 959 MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1007
Query: 613 AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 659
++ E+ D+ E E+K ++ +E + E V KK + E
Sbjct: 1008 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 660 MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
+K++ E + +QI+DL+ +IAEL+ Q A +E A R ++E Q K
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1114
Query: 720 HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
+ +K+R EL+ ++ Q + ER + E++ R L +ELE E
Sbjct: 1115 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1162
Query: 780 VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 839
+ TL+ ++EL K ++E+ ++ ++ E +Q++ Q Q V E E
Sbjct: 1163 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219
Query: 840 QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 899
++ K + + K E E +L E + +E ++K Q
Sbjct: 1220 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1268
Query: 900 REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 954
+E+ K + LN V + Q ++ + + N +E + L+ + L S +L
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1324
Query: 955 REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1014
++ +E+L + + S +L +LE E + + ++ ++ A +N+ + +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1373
Query: 1015 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074
ST +L K++Q S + L+ G + ++E+E +L QQ EE
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1423
Query: 1075 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1134
L++ + +E + ++ +Q + LE L A++ +
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1135 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
+ R K+ + ++ L + LE E +L T E + + + ELE S+
Sbjct: 1484 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 1194 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1244
T+ E+K Q+ +L+++L L + + + K Q DL ++K + L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 1245 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1297
+R +Y+ ED ++ L+ +L+ +E + D A++ +E ++ +LQ
Sbjct: 1602 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658
Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
++K + E S DE+ +E L+ + +LQE + + +A
Sbjct: 1659 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1714
Query: 1358 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1411
LE E+ E + L L++ R+ + + + EE ++E +E + + K
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 1412 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
++E+A T Q ++ ++ QN+ + + + G F ++TIA LE + +
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1832
Query: 1467 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1514
L+E + K+ T +KQKD +L E E E+ K +++++
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 1515 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1574
+E ES+++ L+ E+ E + ++ L S+ +T V +
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1951
Query: 1575 QKMVENLKKQISELKIKNQQLDLENTELSQ 1604
++++EN SE + + D T+ S+
Sbjct: 1952 RRVIENADG--SEEETDTRDADFNGTKASE 1979
Score = 148 bits (374), Expect = 5e-35
Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)
Query: 351 ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
A E+EL TK +A + E++ L ++ Q+ EK L+ L +L + A E+
Sbjct: 863 AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 916
Query: 411 DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 459
AA ++ E L +++ EE ++R L+ E +K +Q+L ++A +Q+L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 460 ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 508
+LE+ +AK ++ + D + + +N++L E +LLE AE+ + +NLT
Sbjct: 977 QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1033
Query: 509 KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 564
KL+ E++++E + + S E + +L +++ Q LQ Q+ EL+ +L
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 565 -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 604
+E Q + RL KN+ +++ G I + + L SE
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 605 ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
L ++++ ++++ + +++ L+ L+++ R +E Q+ E +A E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 659 NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
+ ++ E L+K L+ E A+L G+ VL +A E E +KK+L+ +++
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1269
Query: 716 E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 753
E + L +K+ +LQ+E+E + L +A+ AS + + Q
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 754 SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
E + + ++ +L Q +E+ SL ++ L++E K+ LE+H L + +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 813 CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 857
S +EA +FQ + + +T++ E L+ + R +QEL DL + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 858 RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 895
R+ EK Q +F++ DE + AEA+E KET L R +L
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1504
Query: 896 LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
+E E K K + +V + + + +LE + ETQ + Q+ EL+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560
Query: 953 ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
EL+ E+ + + Q + ER D++ +E +L + ++ E ++RA
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620
Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
+ +L+ +K+++ LQ+ + G EE ++Q +L + D
Sbjct: 1621 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1664
Query: 1073 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1117
L+ A KEN K A ++ +LQ+ L E L +E
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 1118 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1166
A+ G A Q E + R Q +E ++ R + + +++ + +T
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 1167 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1220
S+ Q+ E ++ E + E+E + +++ +S L+ +I+QL+EQ+ +
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 1221 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1269
A+ +K + L + ++ + KM E+ E + K K E+ E+ +
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 1270 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1326
R ++ DEA E+N+ + EV L+ +L++ E +F+ +S IEN +
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1959
Score = 139 bits (351), Expect = 2e-32
Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)
Query: 560 LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 619
LQ +E Q + L ++ E +E +H +EE N L ++AE +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 620 MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 679
E+ + + ELE+ + E +L+E +E+ Q+ + E + +Q+ DL+
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 963
Query: 680 NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 739
++ E + L+ A + ++ + ++ V ++++ L ++ +L L+ R++
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1017
Query: 740 AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
+ E EEK + LT +L+ H+ ++ L + L+KEE ++ LEK +
Sbjct: 1018 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1064
Query: 800 RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
R+L+ + +QI A+ + K E ++AL L+ Q+ L++ +
Sbjct: 1065 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123
Query: 860 EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 917
E + ++D ++ A + E KR+ L +E E L+ ++ L+S +
Sbjct: 1124 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1174
Query: 918 -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 976
R + Q++ L+ + + Q+ E++ H + + E E L Q ++ + +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 977 RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
LE E+ QE + KL A ++ C +R RAE++ ++ +LQ+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Query: 1024 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1068
+ IK + S S LQ +++ EE + + L+Q E+ E
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1352
Query: 1069 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
N L Q E K+N++ ++T +L +KL+ L+E F
Sbjct: 1353 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1184
T+ + ++ T+ + +L DD V DL + S++++++ K ++ A +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
S E R E+ + + + + + L + A E K++L +LK +++ L
Sbjct: 1469 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 1245 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1304
S K +DV + L++ R +ET+ +E +EL E+ +D ++E
Sbjct: 1524 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 1305 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1358
+ E+ +NEE + R + E +L++ QR E L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633
Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1418
++LE++ D I + EE + ++R + +++ ++E LE +A +
Sbjct: 1634 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1678
Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1477
T + ++++ + L+ Q+ + + +LEK +L +EL L R
Sbjct: 1679 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 1478 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
+ +++ L+A + L+ E Q +E + K Q+ L NE+
Sbjct: 1732 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
T + L +E+ K + E A K K I+ L+ K QL+
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1835
Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1652
+ + +++ + L++ +++L E+L Q E E + + + EK N LK +LE
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 1653 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1691
+ +S + ++ L+ EL E + +E + LK +L +
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 110 bits (276), Expect = 1e-23
Identities = 221/1124 (19%), Positives = 459/1124 (40%), Gaps = 145/1124 (12%)
Query: 1020 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1076
RL +K+K + Q T +Q+ Q E + + + L L+Q L E ++L
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 1077 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1136
+A + E +M ++ +Q L+++ M + L+E +++
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 943
Query: 1137 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1196
R +Q++ ++ L+ +E + +Q ++V E +E + + + +
Sbjct: 944 RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003
Query: 1197 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
L + L+E++ L + EK ++L KLK + + +L
Sbjct: 1004 -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1050
Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
E+ SR+ L++ R +E + E +L A++ L+ +L K EE E +L +
Sbjct: 1051 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1106
Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
DE+ +N L + L+G I LQE + +R E +L E + +L T
Sbjct: 1107 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165
Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1435
L+ + K+E + L E+ ++HE + R ++
Sbjct: 1166 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1210
Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
+EE T L Q + A L+ K L++ L + +L + K + H K++
Sbjct: 1211 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1262
Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1547
+L+A + +LQ CS+ ++ L + KLQ E N I + S+S+
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 1548 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
T QEE QK V + +++ +L+ Q+ E Q L+ + L+ + S
Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 1608 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1654
+++KLQ+ Q+ E L Q+ +E +A ++ E+ K L++EL+
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1440
Query: 1655 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1707
V LVS+LE + + K + +++N K DE ++ + R + +
Sbjct: 1441 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
+ L E+L + + L E+ D ++ + + +++ +++ E Q +K+QL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1821
++++Q ED + + M +K DL+ ++ E ++++ LH+ + +
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 1822 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR- 1880
+ A L K L + E+ + ++ +LQ +++ + EL +R
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1673
Query: 1881 -------------EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQ 1920
+K + LE++L+ + + EK L E +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733
Query: 1921 FQKEQSPANRKVSQMNS-LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1979
Q E+ +++Q+ LE+E + ++ ++K + ++ E+ RSTA + S
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 1980 HAWDLQLLQQQACPMVPREQFLQ------LQRQLLQAERINQHLQEELENRTSETNTPQG 2033
Q L++Q + + ++ + + E L+E++E E
Sbjct: 1794 R----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE------KVNQLKEQV 2071
+ +Q ++E +++VE + K+ ++ ++ +V QLK Q+
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Score = 106 bits (264), Expect = 3e-22
Identities = 210/977 (21%), Positives = 408/977 (41%), Gaps = 126/977 (12%)
Query: 1169 VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQ 1228
V RQE +++ E ++ E + E + EL+ + SQL E+ +L ++
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELK--ELEQKHSQLTEEKNLL----------QE 901
Query: 1229 DLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKE 1288
L + + + +M R+ A+ K +L E++ E + EE E R + K+
Sbjct: 902 QLQAETELYAEAEEMRVRL--AAKKQEL--EEILHEMEARLEE---EEDRGQQLQAERKK 954
Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG-KIEKLQESVVQ 1347
+ ++ L+++L++ EE L LEK E KI+ E +LV+ Q K+ K ++ + +
Sbjct: 955 MAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 1348 RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL 1407
R + E E N+ +L E +I E + + E + Q L
Sbjct: 1014 RISDLTTNLAEEE---EKAKNLTKLKNKHES----------MISELEVRLKKEEKSRQEL 1060
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-- 1465
EK+K L G E+ I E L K + QA +A L+ E
Sbjct: 1061 EKLKRK----LEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEIAQK 1113
Query: 1466 -----KLQELTRKLKERVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKV 1515
K++EL + + L ++ + EK+ EEL+A+ +L+ T +
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 1516 ELLRYESEKLQQENSILRNEIT--TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAA 1573
EL K +QE ++L+ + T + E + ++ + EE+ ++ E K+ A
Sbjct: 1174 EL----RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKAN 1228
Query: 1574 VQKMVENLKKQISEL--------------KIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
+ K + L+K+ ++L + K ++L+ + EL K S + ELN +
Sbjct: 1229 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE---VKIQTH 1676
+ ++ Q E E L E E + L +++ Q L+ E + V +
Sbjct: 1289 VHKL--QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 1677 IVQQENHLLKDELEKMKQLHRCPD---------LSDFQQKISSVLSYNEKLLKEKEALSE 1727
+++E + L+D+L++ + + + LSD ++K+ S E L + K+ +
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 1728 ELNSCVDKLAKSSLLEHRIATMKQE-QKSWEHQSASLKSQ--LVASQEKVQNLEDTVQNV 1784
E+ + + + + ++ K Q+ + L +Q LV++ EK Q D +
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1785 NLQMSRMKSDLRVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
+S +D R + E EA ++E +SL + L+ A E+ L + + L
Sbjct: 1467 EKNISSKYADER-DRAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDL 1523
Query: 1843 SWDKLD-----HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP-KHQK 1896
K D H + + ++ L + E ++T ++ + EL + + +LE N+ K Q
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 1897 HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK----VSQMNSLEQELETIHLENEGL 1952
+ E+++ L+R+ +++ E ++ + LE +L+ + L+ +
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 1953 KK------KQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQR 2005
K KQ+ KL Q+ + Q A S + +++A + +QLQ
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQE 1701
Query: 2006 QLLQAERIN-------QHLQEELENRTSETNTPQGNQEQL---VTVMEERMIEVEQKLKL 2055
L AER + L EEL + S N Q + +L + +EE + E + ++
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 2056 VKRLLQEKVNQLKEQVS 2072
+ ++ K Q EQ+S
Sbjct: 1762 MSDRVR-KATQQAEQLS 1777
Score = 41.6 bits (96), Expect = 0.008
Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)
Query: 329 QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 386
+E+ + L SL G L + LE + + + Q + + +R ++ +Q+
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 387 REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 439
E RS K E + +ER+N+ KL E ++K IAAL
Sbjct: 1778 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826
Query: 440 KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 499
+ ++ + EQ+ Q+A + +Q K+ +++ + L +++ ++ + E AEK
Sbjct: 1827 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 500 LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 559
+L+R LE + + S +L + +E + +V+
Sbjct: 1882 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 560 LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
L+S+L R +P + S V N+ G E E
Sbjct: 1931 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1964
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 155 bits (393), Expect = 3e-37
Identities = 379/1840 (20%), Positives = 758/1840 (41%), Gaps = 310/1840 (16%)
Query: 340 DGNINLTELTLALENELLVT-KNSIHQAALASFKAEIRHLLERVDQVVREKEKLR----S 394
+G+++ + E++++V K S + + + +L+ + V +E LR S
Sbjct: 1032 EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPS 1090
Query: 395 DLDKAEKLKSLMASEVDDHHAAIERRN-----------EYNLRKLDEEYKERIAALKNEL 443
+ DK +K +++ SE +D +E + + ++ E + + +LK EL
Sbjct: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150
Query: 444 RKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR-LALSLKENSRLENE-----LLENA 497
+E+ +++ K + E++ KT+E + L L + + + +E L
Sbjct: 1151 IFAQEEKIKELQKIH---QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207
Query: 498 EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 557
L EY K + N E+ E GD + + LQ+ R +++ L ++V
Sbjct: 1208 SVLGEYYTPALKCEVNAED--KENSGDYISENEDPELQDYRYEVQ--DFQENMHTLLNKV 1263
Query: 558 DE-------LQSELEEYRAQ---GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
E LQ+ L + Q G L +N P EE E
Sbjct: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF------------------- 1304
Query: 608 NMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 666
+SI +++ +E + H + L+ + K+ ++L+ + S ++ + +Q +E
Sbjct: 1305 -LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEA 1363
Query: 667 ETHTLEKQISDLKNEIA--ELQGQAAVLKEAHHEATCRHEE-EKKQLQVKLE-------E 716
E H L+K++ + L + V+ E+ + T KK + +E +
Sbjct: 1364 EIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVK 1423
Query: 717 EKTHLQEKLRLQHEMELKARLTQA----------QASFEREREGLQSSAWTEEKVRGLTQ 766
E+T++ + L Q++ +L+ + + Q R G +++A +++ Q
Sbjct: 1424 EETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQ 1483
Query: 767 ELEQFHQEQLTS-LVEKHTLEKEELR-KELLEKHQRELQE-GREKMETECNRRTSQIEAQ 823
E F++ +L+ + T E +++ KE + +EL E G+E + + + +
Sbjct: 1484 EQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----DIP 1539
Query: 824 FQSDCQ-KVTERCES------ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT---Q 873
DC ++E S QS+ D Q + Q E + EL Q
Sbjct: 1540 ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQ 1599
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
E +A ELL++ R+ +++E L++ K LN + +R + D E+L VSE
Sbjct: 1600 EHQQATELLRQAHMRQMERQ---REDQEQLQEEIKR-LNRQLAQRSSI--DNENL--VSE 1651
Query: 934 TQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL 993
++ LL EL++ + L RE++ C+ S ++Q E + + E Q K
Sbjct: 1652 RERVLLE----ELEALKQLSLAGREKLCCELRNS---STQTQNGNENQGEVEEQTFKEKE 1704
Query: 994 LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGD 1053
L + E ER + +RL + E+ + T+ + EE G
Sbjct: 1705 LDRKP-EDVPPEILSNERYALQKANNRLLKILLEVVKTTAAV------------EETIGR 1751
Query: 1054 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSC 1113
L +L + + L + E +VK V E +R+
Sbjct: 1752 HVLGILDRSSK---SQSSASLIWRSEAEASVKSCVH--EEHTRVT--------------- 1791
Query: 1114 LDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE----DDEVRDLGSTGTSSV 1169
DE + G+ + + + T++ +++R V S D E +L +S +
Sbjct: 1792 -DESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850
Query: 1170 QRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQD 1229
Q K+ EA E S+LE+++ T+TE ++ Q QE A+E
Sbjct: 1851 QAAVEKL--LEAISETSSQLEHAKVTQTEL--MRESFRQKQE-----------ATES--- 1892
Query: 1230 LLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREN---DCLQEELRMMETRYDEALENN 1286
LK + ++ ER+ E S + L ++S+ D +E + E + E +
Sbjct: 1893 -------LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDII 1945
Query: 1287 KELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVV 1346
L E+ + L++ LE +++ E E L+ ++ + +++ ++
Sbjct: 1946 DRLEQELLCASNRLQE----------LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995
Query: 1347 QRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL 1406
Q + + E LE++ Q + ++ +V+++ +EE Q ++++E
Sbjct: 1996 QETE----KLMKEKLEVQ-----CQAEKVRDDLQKQVKALEIDVEE--QVSRFIE----- 2039
Query: 1407 LEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
LE+ K E+ L R QNQ + ++ + F D+ + E E+
Sbjct: 2040 LEQEKNTELMDL-----------RQQNQALEKQLEKMRKFLDEQ------AIDREHERDV 2082
Query: 1467 LQELTRKLKERVTILVKQKDVLSHGEKE-EELKAMMHDLQITCSEMQQKVELLRYESEKL 1525
Q+ +KL++++ ++ + + + H +E E+L + + CSE+ E L+ + ++
Sbjct: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142
Query: 1526 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
+E L + L + +S + +QK E K A K +L+ Q+
Sbjct: 2143 NEEIEKLEFRVRELEQALLVS-----------ADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
Query: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE--KEPGNSALEEREQEK 1643
+ + + E T L ++ Q +E+L+ N+ + ++ Q E K+ + L+E EQE
Sbjct: 2192 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQEN 2251
Query: 1644 FNLKEELERCKV------------------QSSTLVSSLEAELSEVKIQTHIVQQENHLL 1685
K+++E+ + + + ++ E E+ ++ Q +QQ+ +
Sbjct: 2252 KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2311
Query: 1686 KDE--LEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1743
D +E+ +L R D + +I ++S E + + +E E+LN ++KL +
Sbjct: 2312 TDNKVIEEKNELIR-----DLETQIECLMSDQECVKRNREEEIEQLNEVIEKL------Q 2360
Query: 1744 HRIATMKQEQKSWEH----QSASLKSQL-VASQEKVQNLEDTVQNVNLQMSRMKSDLRVT 1798
+A + Q+ H ++ SLK QL V EK+ LE V+ N +M+ MK+ L+ T
Sbjct: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA-LEQQVETANEEMTFMKNVLKET 2419
Query: 1799 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDK--LDHLMNEEQQ 1856
+ L QE+ SL ++ ++ PE + + + H LS DK L+ ++ E+
Sbjct: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDH-----LSKDKPELEVVLTEDAL 2474
Query: 1857 LLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKR 1916
+ ++ +N K + + ++ QLES + K + T+ K +K
Sbjct: 2475 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKD---------LELTQCYK-QIKD 2524
Query: 1917 ECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPS 1976
+Q Q E +K+ + + +E L + Q++L+ + + T S
Sbjct: 2525 MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS------QIQLEAVQEYAKFCQDNQTIS 2578
Query: 1977 PSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQE 2036
P ++Q L Q RE L L RI+ ELE++ E +T ++
Sbjct: 2579 SEPERTNIQNLNQL------REDELGSDISALTL-RIS-----ELESQVVEMHTSLILEK 2626
Query: 2037 QLVTVMEERMIEVEQKLKLVKRLLQ--EKVNQLKEQVSLP 2074
+ V + E+ ++E E+KL +++LL+ EK + KE+ P
Sbjct: 2627 EQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666
Score = 150 bits (380), Expect = 1e-35
Identities = 384/1911 (20%), Positives = 764/1911 (39%), Gaps = 300/1911 (15%)
Query: 350 LALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMAS- 408
L L++ VTK S +A S E L + ++ + E+ LR ++ SL+ S
Sbjct: 1070 LILDHLPSVTKESSLRATQPS---ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
Query: 409 EVDDHHAAIERRNEYNLRKLDEEY----KERIAALKN----ELRKEREQILQQAGKQRLE 460
VD +E + L L EE +E+I L+ EL+ + Q GK
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Query: 461 LEQEIEKAKTEE-NYIRDRLALSL----------------KENS---------------- 487
L +++KA +EE +Y L L KENS
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 488 -----------RLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFL 534
L N++ E KL + +K+ + + +FG+ L EF
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306
Query: 535 QEERLTQMRN---EYERQCRVLQD-QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANS 590
++T + + ++ + LQD + +L+ +++E + L+ LK + + EA
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKET-EQNYEAEI 1365
Query: 591 GGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV----------- 639
++ SE P ++ +++ ++ E ++ C++ ++ +
Sbjct: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
Query: 640 --------RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 691
+ Y++QL+E V K +M +T L + +N + Q A
Sbjct: 1426 TNIVKLLEKQYQEQLEEEVA---KVIVSMSIAFAQQTE-LSRISGGKENTASSKQAHAVC 1481
Query: 692 LKEAHHEATCRHEEEK------KQLQVKLEEEKTHLQEKLRLQHEMELKAR--------- 736
+E H+ + +++ + + VK +EE L ++L +H E+
Sbjct: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG-EHGKEILLSNSDPHDIPE 1540
Query: 737 -----LTQAQASFERER---------EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 782
LT ++ F +++ + + S+ + L +E + +++L ++
Sbjct: 1541 SKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE 1600
Query: 783 HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK-VTERCESALQS 841
H E LR+ + + +R+ +E +E+++ E R Q+ + D + V+ER L+
Sbjct: 1601 HQQATELLRQAHMRQMERQ-REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEE 1659
Query: 842 LEGRYRQELKDLQEQQREE------KSQWEFEKDELTQECAEAQELLKETLKR--EKTTS 893
LE LK L RE+ S + + Q E Q ++ L R E
Sbjct: 1660 LEA-----LKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPP 1714
Query: 894 LVLTQEREMLEKTYKEHLNSM--VVERQQLLQD--------LEDLRNVSETQQSLL--SD 941
+L+ ER L+K L + VV+ +++ + D + S++ SL+ S+
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
Query: 942 QILELKSS-HKRELREREEVLCQAGASEQLA----------------SQRLERLEM---E 981
+KS H+ R +E + S+ SQRL R E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834
Query: 982 HDQERQEMMSKL-----LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLS 1036
D E +E+M + A+E + +A ET+ + T+ ++ ++ Q+AT L
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894
Query: 1037 MLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISR 1096
+ + + EE + L + E +++ D +R ++ ++ E+
Sbjct: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954
Query: 1097 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
RLQ+LE E + + P ++Q ++ E + + + + +
Sbjct: 1955 ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP-VEQQLLQETEKLMKEKLEVQCQAE 2013
Query: 1157 EVRDLGSTGTSSVQRQEVKIE-ESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM 1215
+VRD +Q+Q +E + E V F ELE +E TE +L+ Q L++QL
Sbjct: 2014 KVRD-------DLQKQVKALEIDVEEQVSRFIELE--QEKNTELMDLRQQNQALEKQLEK 2064
Query: 1216 LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1275
+ D E+ D + V +++++ LE+ + P+++ + E +RE + L L+
Sbjct: 2065 MRKFLD---EQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
Query: 1276 ETRYDEALENNKELTAEVFRLQDELKKME-EVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
+ E L + ++L ++ +E++K+E V E +L S D + + + +
Sbjct: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
Query: 1335 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1394
+ ++ + +R E + NLE + + Q + LE V+ +H +E K
Sbjct: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEEQLE----QFREELENKNEEVQQLHMQLEIQK 2237
Query: 1395 QENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF--- 1451
+E+ T+L E + +++ + ++ + + + + QD+H
Sbjct: 2238 KES-----TTRLQELEQENKLF-----------KDDMEKLGLAIKESDAMSTQDQHVLFG 2281
Query: 1452 QHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK----EEELKAMMHDLQIT 1507
+ I E E+E +L E KL++++ I K + E E +++ +M D +
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2341
Query: 1508 CSEMQQKVELLRYESEKLQQENSILRNEIT----TLNEEDSISNLKLGTLNGSQEEMWQK 1563
++++E L EKLQQE + + + + +L+EE +L + + + Q+
Sbjct: 2342 KRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 2401
Query: 1564 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1623
ET +E + +K + E K QL E L ++ ++ EK+Q + +
Sbjct: 2402 VETANEE-------MTFMKNVLKETNFKMNQLTQELFSLKRER-ESVEKIQSIPENSV-- 2451
Query: 1624 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQS---STLVSSLE--AELSEVKIQTHIV 1678
N A++ ++K L+ L ++S T S E + S + ++T ++
Sbjct: 2452 ---------NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL 2502
Query: 1679 QQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN----EKLLKEK-----------E 1723
Q E+ + +LE + + D+ + Q + +L +K+++EK E
Sbjct: 2503 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2562
Query: 1724 ALSEELNSCVDKLAKSSLLEH-RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQ 1782
A+ E C D SS E I + Q ++ L S + A ++ LE V
Sbjct: 2563 AVQEYAKFCQDNQTISSEPERTNIQNLNQLRED------ELGSDISALTLRISELESQVV 2616
Query: 1783 NVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
++ + K + + ++ +++++ L K L+ K E P + +
Sbjct: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK--- 2673
Query: 1843 SWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSG 1902
+ +L H + E+ + E E L+ TKAEL +EK +L+ LL K
Sbjct: 2674 TTTELFH--SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK--------- 2722
Query: 1903 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1962
E SL+++ Q + + A K+S LE+E ET E + K+ + E
Sbjct: 2723 -----ETNMTSLQKDLSQVRDHLAEAKEKLS---ILEKEDET-----EVQESKKACMFEP 2769
Query: 1963 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMV-PREQFLQLQRQLLQAERINQHLQEEL 2021
L ++ +S A+ + L++ P + + +Q+ LQ+E ++ + E +
Sbjct: 2770 L-PIKLSKSIASQTDG----TLKISSSNQTPQILVKNAGIQIN---LQSECSSEEVTEII 2821
Query: 2022 ENRTSETNTPQGNQEQLVTVMEERMIEVEQKLK----LVKRLLQEKVNQLK 2068
T + Q + ME R I + LK + +LL+E+ LK
Sbjct: 2822 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLK 2872
Score = 146 bits (369), Expect = 2e-34
Identities = 394/2002 (19%), Positives = 787/2002 (39%), Gaps = 331/2002 (16%)
Query: 327 NSQEILKALDFSLDGNINLTELTLALENELL------VTKNSIHQAALASFKAEIRHLLE 380
N Q+ + D ++ + LTE + L+ + +NS H + A + +L
Sbjct: 213 NLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
Query: 381 RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALK 440
Q+ E++ L D K ++ ++ S + + E + +K++ KE I +
Sbjct: 273 HQQQL-EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD---KKVENSNKEEIQEKE 328
Query: 441 NELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 500
+ + +I+++ K+ LEL+ ++ A +++++ +E ++ EL + +K
Sbjct: 329 TIIEELNTKIIEEE-KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKE 387
Query: 501 AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
+ +L +E + D + + + +M E +R+ L+ ++DE+
Sbjct: 388 RQSSEEIKQLMGTVEELQKRNHKDSQ-------FETDIVQRMEQETQRKLEQLRAELDEM 440
Query: 561 ---------QSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI--EPEHGLGSEECNPLNM 609
Q + ++ AQ ++ K + + S E + L + N LN+
Sbjct: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500
Query: 610 SIE-AELVIEQMKEQHH---RDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
++ E++KE+ + C L+ +LED V ++L + ++A++ + ++
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLV----EELSFSREQIQRARQTIAEQES 556
Query: 666 --NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE---EEKTH 720
NE H + DLK EI E+ E +HE E ++KLE +EK
Sbjct: 557 KLNEAHKSLSTVEDLKAEIVSAS-------ESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Query: 721 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVR--GLTQELEQFHQEQLTS 778
+ +++ E EL+ TQ S E E L+ E ++ L L +++Q+
Sbjct: 610 VLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG 669
Query: 779 L-------VEKHTLEKEELR----------KELLEKHQRELQEGREKMETECNRRTSQIE 821
L +E EK+ L +L + Q + E+M + N +IE
Sbjct: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 822 AQFQSDCQKVT-ERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 880
Q + +K T E+ LQ +++K+ + +E+ +Q E E L E ++
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
Query: 881 LLK--ETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSL 938
+LK + +E+ + + + + + +++ + ++ E + L Q L E Q++
Sbjct: 790 MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
Query: 939 LSDQ-----------------ILELK-----SSHKRELREREEVLCQAGASEQLASQRLE 976
S +L++K S +K+EL + ++ +E+L QR+
Sbjct: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL---KALNEELHLQRIN 906
Query: 977 RLEME-----HDQERQEMMSKLLAMENIHKATCETAD------RERAEMST--------- 1016
++ D+++ + L E + K T E + RE+ E+S
Sbjct: 907 PTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQL 966
Query: 1017 -----EISRLQSKIKEMQQATSPLSMLQSGCQVI-----GEEEVEGDGALSLLQQGEQLL 1066
EIS L ++K ++Q +S+ ++I E D +S L G +
Sbjct: 967 KQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTM 1026
Query: 1067 EENG------DVLLSLQRAHEQAVKENVKMAT----EISRLQQRLQKLEPGLVMSSCL-- 1114
G V S + V++ V E S+ +Q + P + S L
Sbjct: 1027 TSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRA 1086
Query: 1115 ------DEPATEFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVLSDLEDDEVRDLGST 1164
D+ E +EQ + LQ + V V +E+++ + L S
Sbjct: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQ--------LMML 1216
+ QE KI+E + + + ++ET E L I +LQ+ L L
Sbjct: 1147 KEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
Query: 1217 CA----------DCDRASEKK---------------QDLLFDVSVLKKKLKMLERIPEAS 1251
C+ C+ +E K QD ++V ++ + L + + +
Sbjct: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTL--LNKVT 1264
Query: 1252 PKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT---E 1308
+Y L +R + ++ M+ + E EN + E + ++ +E++ +
Sbjct: 1265 EEYNKLLVLQTRLSKIWGQQTDGMKLEFGE--ENLPKEETEFLSIHSQMTNLEDIDVNHK 1322
Query: 1309 TFLSLEKSYDEVKIENE--ELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD 1366
+ LS + ++ K+E + EL L+ LQ ++++ +++ +EA + L+
Sbjct: 1323 SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQN---------YEAEIHCLQ---- 1369
Query: 1367 GNILQLNQTLEECVPRVRSVHHV-IEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH 1425
+L E VP V V I E + G+ VK + + GTI+
Sbjct: 1370 ---KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSC-----VKKN----IDGTIE-- 1415
Query: 1426 QERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK 1485
+ ++E T ++ +K +Q Q L+E K+ ++I Q+
Sbjct: 1416 -----FSGEFGVKEETNIVKLLEKQYQEQ------------LEEEVAKVIVSMSIAFAQQ 1458
Query: 1486 DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESE------------KLQQENSILR 1533
LS +E A C + Q ++ + K ++E L
Sbjct: 1459 TELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLS 1518
Query: 1534 NEITTLNEEDSISNLKLGTLNGSQ-------EEMWQKTET--VKQ---ENAAVQKMVENL 1581
E+ +E +SN + S+ EEM+ K +T V+Q + +V M +
Sbjct: 1519 KELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASR 1578
Query: 1582 KKQISELKIKNQQLDL--------ENTEL--------SQKNSQNQEKLQELNQRLTEMLC 1625
+ ++E ++++ + +L + TEL ++ ++QE+LQE +RL L
Sbjct: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638
Query: 1626 QKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL 1685
Q+ + + ERE+ L EELE K S L EL QT + +
Sbjct: 1639 QRSSIDNENLVSERERV---LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695
Query: 1686 KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLA--KSSLLE 1743
+++ K K+L R P+ D +I S Y L K L + L V A + ++
Sbjct: 1696 EEQTFKEKELDRKPE--DVPPEILSNERY--ALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 1744 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL-RVTQQEK 1802
H + + + KS S +S+ AS + + E T S SD+ R
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
Query: 1803 EALKQEVMSLHKQLQNAG--GKSWAPE----IATHPSGLHNQQKRL------SWDKLDHL 1850
+ +E L ++L +G G PE + S L ++L + +L+H
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 1851 MNEEQQLLWQENERLQTMVQNTKA-----ELTHSREKVRQLESNLLPKHQKHLNPSGTMN 1905
+ +L+ + + Q ++ K E H + R+ + L K + G ++
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE------GVID 1925
Query: 1906 PTEQEKLSLKREC-------DQFQKEQSPANRKVSQMNS----LEQELETIHLENEGLKK 1954
EK +R+ D+ ++E A+ ++ ++ + +++E E + + E +K
Sbjct: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
Query: 1955 KQVKLDEQLME----MQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQ---FLQLQRQ- 2006
+ +++QL++ + + DLQ Q +A + EQ F++L+++
Sbjct: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK-QVKALEIDVEEQVSRFIELEQEK 2044
Query: 2007 ---LLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEK 2063
L+ + NQ L+++LE + ++E V ++ + ++EQ+LK+V R
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104
Query: 2064 VNQLKEQVSLPGHLCSPTSHSS 2085
+Q +E L HL T S
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCS 2126
Score = 135 bits (339), Expect = 5e-31
Identities = 366/1905 (19%), Positives = 747/1905 (39%), Gaps = 299/1905 (15%)
Query: 322 EEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 381
EEG E SQ ++++ + + EL L + + L + +A ++ +++ H
Sbjct: 1816 EEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA-ISETSSQLEHAKVT 1874
Query: 382 VDQVVRE--------------KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRK 427
+++RE +E+LR L + + + +A E+ I+ +
Sbjct: 1875 QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD----- 1929
Query: 428 LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 487
++ ER K ++ EQ L A + ELE E ++ + E + + E
Sbjct: 1930 -EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988
Query: 488 RLENELLENAEKLA----EYENLTNKLQRNLENVLAEKFGDLDPSSAEFF-LQEERLTQM 542
+E +LL+ EKL E + K++ +L+ + D++ + F L++E+ T++
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048
Query: 543 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 602
+ +Q + L+ Q+++++ L+E E E + +
Sbjct: 2049 M-DLRQQNQALEKQLEKMRKFLDEQAIDR----------------------EHERDVFQQ 2085
Query: 603 ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 662
E L ++ + + E R++ L L++K + E ++S ++ Q ++++
Sbjct: 2086 EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT----DKCSELLLSKEQLQRDIQE 2141
Query: 663 RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
R+E E LE ++ +L+ + +++ H + E L+V+L+ E+ +
Sbjct: 2142 RNE-EIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELS-LEVQLQAERDAID 2199
Query: 723 EKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE- 781
K + +T + E+ RE L++ E+V+ L +LE +E T L E
Sbjct: 2200 RK---------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL 2247
Query: 782 --KHTLEKEELRK-----------------ELLEKHQRELQEGREKMETECNRRTSQIEA 822
++ L K+++ K L K + +QE +++ + N + ++++
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID-QLNEQVTKLQQ 2306
Query: 823 QFQ-SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL 881
Q + + KV E ++ LE +++ L Q K E E ++L + + Q+
Sbjct: 2307 QLKITTDNKVIEEKNELIRDLE----TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
Query: 882 LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 941
L ++ + L++E + L K L+ ++ E+ L Q +E +++L +
Sbjct: 2363 LANIGQKTSMNAHSLSEEADSL----KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2418
Query: 942 ------QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
Q+ + S KRE E++ S +A L + + E + E K L
Sbjct: 2419 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478
Query: 996 MENIHKATCETADRERAEMSTEISRLQS--------------KIKEMQ-QATSPLSMLQS 1040
+ K+ E + T + +L+S +IK+MQ Q MLQ
Sbjct: 2479 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
Query: 1041 ---GCQVIGEEEVEG----DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE--NVKMA 1091
Q I EE+V L +Q+ + ++N + +R + Q + + ++
Sbjct: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2598
Query: 1092 TEISRLQQRLQKLEPGLV---MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH 1148
++IS L R+ +LE +V S L++ E + E L + + K +EG
Sbjct: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ-KLLEG----- 2652
Query: 1149 VLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELE----NSEETRTESWELKN 1204
++ + E S V + ++ S F+ELE S T+ E K
Sbjct: 2653 --NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKE 2710
Query: 1205 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEAS---PKYKLLYE-- 1259
+ +LQE+L++ + + + ++ K+KL +LE+ E K ++E
Sbjct: 2711 KAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2770
Query: 1260 ----------------------------------DVSRENDCLQEELRMMETRYDEALEN 1285
++ +++C EE+ + +++ E +E
Sbjct: 2771 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2830
Query: 1286 NKEL-TAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQ-------GK 1337
+EL AE+ ++ ++ET + Y V++ EE L +Q
Sbjct: 2831 MQELHAAEILDMES-----RHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2885
Query: 1338 IEKLQES-VVQRCDCC-----------LWEASLENLEIEPDGNILQLNQTLEECVPRVRS 1385
I +L S Q + C ++ + +I +G + + +++
Sbjct: 2886 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKG 2945
Query: 1386 VHHVIEE------CKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE 1439
+ + E+ Y +G +++V + I T + ++ L+
Sbjct: 2946 LLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR 3005
Query: 1440 NTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKA 1499
+ H EL L LQ++ L+ER +L +
Sbjct: 3006 EAEVYDSSQSHESFSDWRGELLL---ALQQVF--LEERSVLLAAFR-------------- 3046
Query: 1500 MMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEE 1559
++T V LL +++Q++ + + L + D S L + +
Sbjct: 3047 ----TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS--LLSEIQALHAQ 3100
Query: 1560 MWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
M + T+K+E + + E L+ I + ++Q L++ Q +L + R
Sbjct: 3101 MNGRKITLKREQESEKPSQELLEYNIQQK--QSQMLEM------------QVELSSMKDR 3146
Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ 1679
TE+ Q++ + E + E K ELE + LEA EVK +T
Sbjct: 3147 ATEL--QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKT---- 3200
Query: 1680 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDK-LA 1737
E HLL D L ++ R +L +K + L +E+ KE+ E L L S + L
Sbjct: 3201 DEVHLLNDTLASEQKKSR--ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
Query: 1738 KSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1797
+ LLE + + + Q+ E Q +QL Q + L+ +++ +++ M S L
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL-- 3316
Query: 1798 TQQEKEALKQEVMSLHKQLQNAGGKSWA-PEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ 1856
+E+E LH QLQ++ G + P + + + L+ E Q+
Sbjct: 3317 -DRERE--------LHAQLQSSDGTGQSRPPLPS-----------------EDLLKELQK 3350
Query: 1857 LLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL-SLK 1915
L +++ R+ ++ T+ S + +Q+E + H+K L N Q+K+ L+
Sbjct: 3351 QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD-RQVHRKTLQTEQEANTEGQKKMHELQ 3409
Query: 1916 RECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK-KKQVKLDEQLMEMQHLRSTAT 1974
+ + Q++ ++V +++ Q L+ I E + + +++ K + + + Q+L T
Sbjct: 3410 SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTT 3469
Query: 1975 PSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQ---EELENRTSETNT- 2030
S + +LQQ+ + +L N L+ ++L+ S+
Sbjct: 3470 WSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVL 3529
Query: 2031 PQGNQE--QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
PQ E Q T +E I V++ + + LQ+ Q E+ SL
Sbjct: 3530 PQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSL 3574
Score = 134 bits (338), Expect = 7e-31
Identities = 332/1570 (21%), Positives = 665/1570 (42%), Gaps = 193/1570 (12%)
Query: 345 LTELTLALEN--ELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAE-K 401
+T L LE E L KN Q + + + R+ ++ +E + + D++K
Sbjct: 2205 ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264
Query: 402 LKSLMASEVDDHH------AAIERRNEYNLRKLDEEYKERIAALK----NELRKEREQIL 451
+K A D H A I + E + +L+E+ + LK N++ +E+ +++
Sbjct: 2265 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2324
Query: 452 QQAGKQR--LELEQEIEKAKTEENY--IRDRLALSLKENSRLENELLENAEKLAEYENLT 507
+ Q L +QE K EE + + + +E + + + NA L+E
Sbjct: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE---A 2381
Query: 508 NKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEY 567
+ L+ L+ V+AEK + E +T M+N + + EL S E
Sbjct: 2382 DSLKHQLDVVIAEKLA----LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2437
Query: 568 RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRD 627
+ ++ +P +NS + ++ S +PE + E S+E + + +E
Sbjct: 2438 ESVEKIQSIP-ENSVNVAIDHLSKD-KPELEVVLTE--DALKSLENQTYFKSFEENGKGS 2493
Query: 628 ICCLR---LELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 684
I L L+LE V + +L + C K ++M+++ + ET L+K+I +L+ +I E
Sbjct: 2494 IINLETRLLQLESTVSAKDLELTQ----CYKQIKDMQEQGQFETEMLQKKIVNLQ-KIVE 2548
Query: 685 LQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 743
+ AA++ + EA + + + Q + E E+T++Q +L+ + EL
Sbjct: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED-EL---------- 2597
Query: 744 FEREREGLQSSAWTEEKVRGLTQELEQFH-----QEQLTSLVEKHTLEKEELRKELL--- 795
G SA T ++ L ++ + H +++ + EK+ LEKE+ EL
Sbjct: 2598 ------GSDISALTL-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL 2650
Query: 796 ---EKHQRELQEGREKMETECNRRTSQI-----EAQFQSDCQKVTERCESALQSLE-GRY 846
EK QRE ++ R + E + T+++ E+ F ++ + + R ES E Y
Sbjct: 2651 EGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEAL--RAESVATKAELASY 2708
Query: 847 RQELKDLQEQQR-EEKSQWEFEKD--ELTQECAEAQELLKETLKREKTTSLVLTQEREML 903
+++ + LQE+ +E + +KD ++ AEA+E L L++E T + +++ M
Sbjct: 2709 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS-ILEKEDETEVQESKKACMF 2767
Query: 904 EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQ 963
E + S+ + L+ + + ++T Q L+ + +++ + E E++ Q
Sbjct: 2768 EPLPIKLSKSIASQTDGTLK----ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQ 2823
Query: 964 AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAE----MSTEIS 1019
++++E+++ H E +L ME+ H + ET RE + E
Sbjct: 2824 F-------TEKIEKMQELHAAE-------ILDMESRHISETETLKREHYVAVQLLKEECG 2869
Query: 1020 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1079
L++ I+ ++ + E+ + S QG L G + S R
Sbjct: 2870 TLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2929
Query: 1080 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQ-TEPFLQQNRT 1138
E++ +I L + + G+ + S + P ++ ++ +Q +EP+L++ +
Sbjct: 2930 -EESESATDSFPKKIKGLLRAVHN--EGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKA 2986
Query: 1139 KQVEGVTRRHVLSDLE---DDEVRDLGST--------GTSSVQRQEVKIEESEASVEGFS 1187
+ + +++ ++ + EV D + G + Q+V +EE + F
Sbjct: 2987 YINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAF- 3045
Query: 1188 ELENSEETRTESWELKNQISQ-LQEQLMMLCA--DCDRASEKKQDLLFDVSVLK-----K 1239
E + T++ L N + Q +QEQ + A +C + ++++ LL ++ L +
Sbjct: 3046 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS-LLSEIQALHAQMNGR 3104
Query: 1240 KLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAE---VFRL 1296
K+ + P +LL ++ ++ + E + + D A E ++L++E V L
Sbjct: 3105 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3164
Query: 1297 QDELKKMEEVTETFLS--------LEKSYDEVKIENEELNVLVLRLQGKIEKLQES--VV 1346
+ EL + + ET L LE EVK + +E+++L L + +K +E +
Sbjct: 3165 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3224
Query: 1347 QRCDCCLWEAS------LENLEIEPDGNI---LQLN-------QTLEECVPRVRSVHHVI 1390
++ L + LE+L+ + LQLN Q L E ++ S +
Sbjct: 3225 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3284
Query: 1391 EECKQENQYLEGNTQLL---EKVKAHEIAW-------LHGTIQ----THQERPRVQNQVI 1436
+ E Q Q+L EKV+ E++ LH +Q T Q RP + ++ +
Sbjct: 3285 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3344
Query: 1437 LEENTTLLGFQDKHFQHQATIAEL--ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKE 1494
L+E L ++KH + I EL E EK KL L + + V +K + + E
Sbjct: 3345 LKELQKQL--EEKH----SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN 3398
Query: 1495 EELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRN-----EITTLNEEDSISNLK 1549
E + MH+LQ ++Q+++E R + KL E L+ + L E+ + +
Sbjct: 3399 TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRR 3458
Query: 1550 LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQN 1609
+ N ++ W T + N +Q+ +E K+ + K+ +++ T + +
Sbjct: 3459 ILYQNLNEPTTWSLTSD-RTRNWVLQQKIEGETKESNYAKL--IEMNGGGTGCNHELEMI 3515
Query: 1610 QEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-LKEELERCKVQSSTLVSSLEAEL 1668
++KLQ + +L ++L QK E E + E F ++E ++ +Q L E
Sbjct: 3516 RQKLQCVASKL-QVLPQKASE--RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEP 3572
Query: 1669 SEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEE 1728
S V T LL+ E + + + + + + V+ E++ ++ +
Sbjct: 3573 SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM--VMKLEEQIRWYRQTGAGR 3630
Query: 1729 LNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQM 1788
NS L + +E IA+ E++ W + +L+ L ++ +V L+ ++N +L
Sbjct: 3631 DNSSRFSLNGGANIEAIIAS---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQ 3687
Query: 1789 SRMKSDLRVT 1798
+ VT
Sbjct: 3688 TLSPDSEHVT 3697
Score = 120 bits (301), Expect = 1e-26
Identities = 270/1290 (20%), Positives = 539/1290 (41%), Gaps = 209/1290 (16%)
Query: 795 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 854
LE + EL + ++E E NR ++ + ++ + + E+A++ +G Q +LQ
Sbjct: 157 LEMMESELAGKQHEIE-ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ 215
Query: 855 EQQREEKSQWEFEKDELTQECAEAQELLK-----ETLKR--EKTTSLVLTQEREMLEKTY 907
+ +R EK + E ELT++ + Q + ETL+ +T+ L Q ++ + T+
Sbjct: 216 QARR-EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI-LTH 273
Query: 908 KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQI--------LELKSSHKRELREREE 959
++ L E+ LL+D + + Q S L ++I ++++S+K E++E+E
Sbjct: 274 QQQLE----EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET 329
Query: 960 VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1019
++ + L +E +++ E+ KL TAD+ E+ +I
Sbjct: 330 II-----------EELNTKIIEEEKKTLELKDKL-----------TTADKLLGELQEQIV 367
Query: 1020 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1079
+ +IK M+ ++ ++ E Q E++ + G V +R
Sbjct: 368 QKNQEIKNMK------------LELTNSKQKE-------RQSSEEIKQLMGTVEELQKRN 408
Query: 1080 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTK 1139
H+ + E + Q++L++L L E +G Q + L +
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAEL----------DEMYGQQIVQMKQELIRQHMA 458
Query: 1140 QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES 1199
Q+E + RH + + L S +V ++K+ + E +
Sbjct: 459 QMEEMKTRH-----KGEMENALRSYSNITVNEDQIKLMNVAIN-----------ELNIKL 502
Query: 1200 WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL-KMLERIPEASPKYKLLY 1258
+ +Q +L+E+L ++ + + +DL+ ++S ++++ + + I E K +
Sbjct: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH 562
Query: 1259 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSY 1317
+ +S D E + E+R + L++ E+T +L+ K+ V + S E
Sbjct: 563 KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
Query: 1318 DEVKIE-----NEELNVLVLRLQGK----IEKLQESV----VQRCDCCLWEAS--LENLE 1362
+ ++ + EEL+ L L+ + IEKL++++ Q+ D E S +E ++
Sbjct: 623 ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ 682
Query: 1363 IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLE----KVKAHEIAWL 1418
E D I + NQ + E + +++ + + K E L+ N E + + E L
Sbjct: 683 FEKDNLITKQNQLILE-ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741
Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTR-----K 1473
+Q Q + + + + E+ L Q+K Q +A + L+ EK L+++ +
Sbjct: 742 EQEVQELQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVS 798
Query: 1474 LKERVTIL--VKQKDVLSHGEKE-EELKAMMHDLQITCSEMQQKVELLR----------- 1519
+ER+ L +K K S EKE E L DL+ C ++ +++E R
Sbjct: 799 QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFE 858
Query: 1520 YESEKLQQENSILRNEITTLNEEDSISNL----KLGTLNGSQEEMWQKTETVKQEN---- 1571
++LQ+E + L L + + L KL LN TVK ++
Sbjct: 859 VNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFD 918
Query: 1572 ------AAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR---LTE 1622
A +M E ++K +EL K + E ELSQ+ S E+L++ + L E
Sbjct: 919 EDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNE 978
Query: 1623 MLCQKEKEPGNSALEEREQE---KFNLKEELERCKVQSSTL------VSSLEAELSEVKI 1673
+ ++E +L RE E N E ++ C Q S+L ++S AE S K+
Sbjct: 979 EVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV 1038
Query: 1674 QTHIVQQENHLLKDEL--------EKMKQ----LHRCPDLSDFQQKISSVLSYNEKLLKE 1721
++ +++D++ E+ KQ L P ++ ++ S N+KL KE
Sbjct: 1039 NKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKE 1098
Query: 1722 KEALSEELNSC-----VDKLAKSSLLEHRIATMKQEQKSWEHQS-ASLKSQLV-ASQEKV 1774
L E N ++ S + + +++ ++ + ++ SLK +L+ A +EK+
Sbjct: 1099 LNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKI 1158
Query: 1775 QNLEDTVQNVNLQMSRMKSD----------LRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824
+ L+ Q L++ MK+ L + + +K A+ +E + L + G+ +
Sbjct: 1159 KELQKIHQ---LELQTMKTQETGDEGKPLHLLIGKLQK-AVSEECSYFLQTLCSVLGEYY 1214
Query: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVR 1884
P + ++ + K S D + + E Q E + Q + ++T K+
Sbjct: 1215 TPALKCE---VNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271
Query: 1885 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1944
L++ L + T+ KL E KE++ SQM +LE +++
Sbjct: 1272 VLQTRLSKIWGQQ---------TDGMKLEFGEE--NLPKEETEFLSIHSQMTNLE-DIDV 1319
Query: 1945 IHLENEGLKK--KQVKLDEQLMEMQHLRST 1972
H + ++ KL+EQ+ E++ L S+
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISS 1349
Score = 115 bits (287), Expect = 6e-25
Identities = 275/1361 (20%), Positives = 570/1361 (41%), Gaps = 240/1361 (17%)
Query: 758 EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 817
++K+ +L QF Q + S + + ++++ RK KH +++CN
Sbjct: 7 QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN--- 63
Query: 818 SQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT--QEC 875
E S ++R ES + E + L + E+ E E + T +C
Sbjct: 64 ---EMYINS-----SQRVESTVIP-ESTIMRTLHSGEITSHEQGFSVELESEISTTADDC 114
Query: 876 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKE--------HLNSMVVERQQLLQDLED 927
+ ++ K T+L L +E ++ +Y E HL M E ++E+
Sbjct: 115 SSEVNGCSFVMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE 173
Query: 928 LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 987
L E + + L+ + +++R+ ++ Q A+ Q A +E+
Sbjct: 174 LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR-----------REKD 222
Query: 988 EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1047
E M + L + T ++ ++ + + ++ +++ +LQ+ Q++
Sbjct: 223 ETMREFLEL---------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273
Query: 1048 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
++ L++ + LLE+ Q KE+ M +IS LQ++++
Sbjct: 274 QQ--------QLEEQDHLLED------------YQKKKEDFTM--QISFLQEKIK----- 306
Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1167
V D+ ++ E +++ TK +E + L D + LG
Sbjct: 307 -VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365
Query: 1168 SVQR-QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1226
VQ+ QE+K + E + E ++SEE + +L + +LQ++
Sbjct: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIK----QLMGTVEELQKR-------------N 408
Query: 1227 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENN 1286
+D F+ ++++ + ++ R+ + L+ EL M + + ++
Sbjct: 409 HKDSQFETDIVQR-----------------MEQETQRKLEQLRAELDEMYGQ--QIVQMK 449
Query: 1287 KELTAEVFRLQDELK-----KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQ---GKI 1338
+EL + +E+K +ME ++ ++ + D++K+ N +N L ++LQ +
Sbjct: 450 QELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
Query: 1339 EKLQESV-VQRCDCCLWEASLENLEIE---PDGNILQLNQTLEECVPRVRSVH---HVIE 1391
EKL+E + + + C + LE+L E I + QT+ E ++ H +E
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF 1451
+ K E + + LE E+ +++ +++ +E +L D+
Sbjct: 570 DLKAEIVSASESRKELELKHEAEVT-----------NYKIKLEMLEKEKNAVL---DRMA 615
Query: 1452 QHQATIAELELEKTKL----QELTRKLKERVTI-----LVKQKDVLSHGEKEEELKAMMH 1502
+ Q AELE +T+L +E KLKE + I + K KD L K++ +
Sbjct: 616 ESQE--AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ-----ID 668
Query: 1503 DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTLNGSQEEMW 1561
LQ +EM QK+E +++E + L + + L EI+ L + + S+ N K + E+
Sbjct: 669 GLQ---NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725
Query: 1562 QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT 1621
++ E ++QE +K L++++ EL++K + L+ ++ +K + QEK +L
Sbjct: 726 KEIEILRQE----EKEKGTLEQEVQELQLKTELLE---KQMKEKENDLQEKFAQL----- 773
Query: 1622 EMLCQKEKEPGNSALEEREQEKFNLKEELE-RCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1680
E NS L++ EK L++ L+ V + L++ S K + + ++
Sbjct: 774 --------EAENSILKD---EKKTLEDMLKIHTPVSQEERLIFLDSIKS--KSKDSVWEK 820
Query: 1681 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
E +L +E E +KQ +C L++ +K + S+ EK + +E +C+ K+ K
Sbjct: 821 EIEILIEENEDLKQ--QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV-KDD 877
Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSD------ 1794
L + S Q KS+L A E++ +Q +N +MKS
Sbjct: 878 L-----------EDSKNKQELEYKSKLKALNEELH-----LQRINPTTVKMKSSVFDEDK 921
Query: 1795 --LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1852
+ T + E ++++ L ++L+ K E++ S L Q K+ + +N
Sbjct: 922 TFVAETLEMGEVVEKDTTELMEKLEVT--KREKLELSQRLSDLSEQLKQKHGE--ISFLN 977
Query: 1853 EEQQLLWQENERLQTMVQNTKAELTHSR-EKVRQLESNLLPKHQKHLNPSGTMNPTEQEK 1911
EE + L QE E++ + + + H+R E V+ ++ + L+ TM E
Sbjct: 978 EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV----SSLLDGVVTMTSRGAEG 1033
Query: 1912 LSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDE--QLMEMQHL 1969
S+ + F +E K+ + + E T+ E K++Q+ LD + + L
Sbjct: 1034 -SVSKVNKSFGEES-----KIMVEDKVSFENMTV---GEESKQEQLILDHLPSVTKESSL 1084
Query: 1970 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2029
R+T +L +L+ + + + + ++ L+ + ++Q ++E +EN
Sbjct: 1085 RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ-VREYMENE----- 1138
Query: 2030 TPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
+ L ++ EE + E+K+K ++++ Q ++ +K Q
Sbjct: 1139 ----KDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ 1175
Score = 113 bits (283), Expect = 2e-24
Identities = 316/1689 (18%), Positives = 682/1689 (40%), Gaps = 287/1689 (16%)
Query: 489 LENELLENAEKLAEYENLTNKLQRNLE--NVLAEKFGDLDPSSAEFFLQEE--RLTQMRN 544
LE+E+ A+ + N + + R + N+L E+ +D S +E Q+ L M +
Sbjct: 103 LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMES 162
Query: 545 EYERQCRVLQDQVDELQSELEEYRA--------------------QGRVLRLP--LKNSP 582
E + Q +++EL ELEE R G + +L L+ +
Sbjct: 163 ELAGK----QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR 218
Query: 583 SEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHY 642
E+ E +E +E+ L + + E ++ H L+ + ++ +
Sbjct: 219 REKDETMREFLEL-----TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273
Query: 643 EKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEI----------------AELQ 686
++QL+E Q+++ + ++ + QIS L+ +I E+Q
Sbjct: 274 QQQLEE--------QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Query: 687 GQAAVLKEAHHEATCRHEEEKKQLQVK-----LEEEKTHLQEKL--RLQHEMELKARLTQ 739
+ +++E + + EEEKK L++K ++ LQE++ + Q +K LT
Sbjct: 326 EKETIIEELNTKII---EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 382
Query: 740 AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
++ + E ++ T E+++ + QF + + + ++ + E+LR EL E +
Sbjct: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442
Query: 800 RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYR---QELKDLQEQ 856
+++ + ++++ + + +++ + + + + R S + E + + + +L +
Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNITVNEDQIKLMNVAINELNIK 501
Query: 857 QREEKSQWEFEKDE----LTQECAEAQEL---------LKETLKREKTTSLVLTQEREML 903
++ SQ E K+E L ++CA ++L +E ++R + T + ++ L
Sbjct: 502 LQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT---IAEQESKL 558
Query: 904 EKTYK-----EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRERE 958
+ +K E L + +V + ++LE T + + + + K++ + E +
Sbjct: 559 NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ 618
Query: 959 EVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEI 1018
E + ++ L S E +++ D E + ++ +N+ + D + EMS +I
Sbjct: 619 EAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678
Query: 1019 SRLQ-----------------SKIKEMQQA---------TSPLSMLQSGCQVIGEEEVEG 1052
+Q SK+K++QQ+ T ++ LQ +++ +EE E
Sbjct: 679 ETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE- 737
Query: 1053 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN-VKMATEISRLQQRLQKLEPGLVMS 1111
L+Q Q L+ ++L + E ++E ++ E S L+ + LE L +
Sbjct: 738 ---KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
+ + + E+ FL ++K + V + + +E++E +++
Sbjct: 795 TPVSQ----------EERLIFLDSIKSKSKDSVWEKEIEILIEENE----------DLKQ 834
Query: 1172 QEVKI-EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL 1230
Q +++ EE E FS E +++E+ Q Q + ++ D S+ KQ+L
Sbjct: 835 QCIQLNEEIEKQRNTFSFAE-------KNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
Query: 1231 LFDVSVLKKKLKM------LERIPEASPKYKLLYEDVSRENDCLQEELRMME------TR 1278
+ K KLK L+RI + K K D + + E L M E T
Sbjct: 888 EY-----KSKLKALNEELHLQRINPTTVKMKSSVFD--EDKTFVAETLEMGEVVEKDTTE 940
Query: 1279 YDEALENNKELTAEVF-RLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1337
E LE K E+ RL D +++++ L + +K E E++++ L+
Sbjct: 941 LMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEII 1000
Query: 1338 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1397
I + VQ CD + DG + ++ E V +V + E+
Sbjct: 1001 INHNRAENVQSCD--------TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
Query: 1398 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV----QNQVILEENTTLLGFQ-DKHFQ 1452
+ N + E+ K ++ H T + R +N + +E L Q D Q
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112
Query: 1453 HQATIAELEL----EKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITC 1508
+A L L +++E K++ +K++ + + EK +EL+ +H L++
Sbjct: 1113 MEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQ-KIHQLELQT 1171
Query: 1509 SEMQQ------KVELLRYESEKLQQE-----------------NSILRNEITTLNEEDSI 1545
+ Q+ + LL + +K E L+ E+ ++E+S
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1231
Query: 1546 SNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK----QISELKIKNQQLDLENTE 1601
+ Q+ ++ + + + + K+ E K Q KI QQ D E
Sbjct: 1232 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1291
Query: 1602 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQS---- 1657
++N +E TE L + ++ + K + ++LE+ K++
Sbjct: 1292 FGEENLPKEE---------TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQE 1342
Query: 1658 -STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDL---------SDFQ-- 1705
+L+SSL+ +L E + + E H L+ L+ + + P L SD Q
Sbjct: 1343 LESLISSLQQQLKETE---QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399
Query: 1706 --------QKISSVLSYNEKL-LKEK----EALSEELNSCVDKLAKSSLLEHRIATMKQE 1752
+ I + ++ + +KE+ + L ++ +++ ++ IA +Q
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459
Query: 1753 QKS-----WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQ 1807
+ S E+ ++S ++ V QE+ E +++S+ + + + K+
Sbjct: 1460 ELSRISGGKENTASSKQAHAVCQQEQHYFNE-------MKLSQDQIGFQTFETVDVKFKE 1512
Query: 1808 EVMSLHKQLQNAGGKSWAPEIATHPSGLHN--QQKRLSWDKLDHLMNEEQQLLWQE--NE 1863
E L K+L G EI S H+ + K + + ++++ + ++ ++
Sbjct: 1513 EFKPLSKELGEHG-----KEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHD 1567
Query: 1864 RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE-CDQFQ 1922
+ + +L + E++ + L+ ++Q+H + + ++ +RE +Q Q
Sbjct: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627
Query: 1923 KEQSPANRKVSQMNSLE-----QELETIHLEN-EGLKKKQVKLDEQLMEMQHLRSTATPS 1976
+E NR+++Q +S++ E E + LE E LK+ + E+L ST T +
Sbjct: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687
Query: 1977 PSPHAWDLQ 1985
+ + +++
Sbjct: 1688 GNENQGEVE 1696
Score = 100 bits (250), Expect = 1e-20
Identities = 250/1201 (20%), Positives = 488/1201 (40%), Gaps = 210/1201 (17%)
Query: 983 DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGC 1042
D+ERQ+ + A + +D + + R S K A L++ QS C
Sbjct: 3 DEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC 62
Query: 1043 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQR----AHEQAVKENVKMATEISRLQ 1098
+ ++ Q+ E + ++ +L +HEQ +V++ +EIS
Sbjct: 63 NEM---------YINSSQRVESTVIPESTIMRTLHSGEITSHEQGF--SVELESEISTTA 111
Query: 1099 QRLQKLEPGLVMSSCLDEPAT----EFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVL 1150
G +P E FG +E Q + T + E ++H +
Sbjct: 112 DDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI 171
Query: 1151 SDL--EDDEVR-DLGSTGTSSVQRQEVKIEESEASVEGFSE-----LENSEETRTESWEL 1202
+L E +E+R G+ G +Q E I++ + + + +ET E EL
Sbjct: 172 EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLEL 231
Query: 1203 KNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL----KMLERIPEASPKYKLLY 1258
Q +LQ Q L A + D+ K+++ + LE Y+
Sbjct: 232 TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291
Query: 1259 EDVSRENDCLQEELRMMETRYDEALEN-NKELTAEVFRLQDELKKMEEVTETFLSLEKSY 1317
ED + + LQE++++ E D+ +EN NKE +Q++ +EE+ + EK
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKE------EIQEKETIIEELNTKIIEEEKKT 345
Query: 1318 DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLE 1377
E+K + + L + +LQE +VQ+ ++N+++E + + Q+ E
Sbjct: 346 LELKDKLTTADKL-------LGELQEQIVQK------NQEIKNMKLELTNSKQKERQSSE 392
Query: 1378 ECVPRVRSVHHVIEECKQEN-----------QYLEGNTQL-LEKVKAHEIAWLHGT--IQ 1423
E ++ + +EE ++ N Q +E TQ LE+++A E+ ++G +Q
Sbjct: 393 E----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA-ELDEMYGQQIVQ 447
Query: 1424 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIA----ELELEKTKLQELTRKLKERVT 1479
QE R + E T G + + + I +++L + EL KL++ +
Sbjct: 448 MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
Query: 1480 ILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1539
QK+ L +EEL ++ + +++ VE L + E++Q+ + + + L
Sbjct: 508 ----QKEKL-----KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
Query: 1540 NEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1599
NE ++ L T+ + E+ +E+ K+ + V N K IK + L+ E
Sbjct: 559 NE----AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK-------IKLEMLEKEK 607
Query: 1600 TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELE-------- 1651
+ + +++QE EL + T++L E+E LKE+LE
Sbjct: 608 NAVLDRMAESQEA--ELERLRTQLLFS------------HEEELSKLKEDLEIEHRINIE 653
Query: 1652 ----RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-----ELEKMKQLHRCPDLS 1702
+ + L+ E+S+ KI+T +++N + K E+ K+K L + S
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQ-KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712
Query: 1703 DFQQKISSV--LSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQ 1759
++ + L ++L+++E L V +L K+ LLE + MK+++ + +
Sbjct: 713 KSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQ---MKEKENDLQEK 769
Query: 1760 SASLKSQLVASQEKVQNLEDTV----------QNVNLQMSRMKS-------DLRVTQQEK 1802
A L+++ +++ + LED + + + L + KS ++ + +E
Sbjct: 770 FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829
Query: 1803 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1862
E LKQ+ + L++++ E + + +++ +L EE L +
Sbjct: 830 EDLKQQCIQLNEEI----------EKQRNTFSFAEKNFEVNYQEL----QEEYACLLKVK 875
Query: 1863 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ 1922
+ L+ K EL + + K++ L L H + +NP+ T + K S+ E F
Sbjct: 876 DDLED--SKNKQELEY-KSKLKALNEEL---HLQRINPT-----TVKMKSSVFDEDKTFV 924
Query: 1923 KEQSPANRKVSQ-MNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHA 1981
E V + L ++LE E L ++ L EQL +
Sbjct: 925 AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKH-------------- 970
Query: 1982 WDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSE---------TNTPQ 2032
++ L ++ + ++ + L+ + L+ IN + E +++ ++ T T +
Sbjct: 971 GEISFLNEEVKSLKQEKEQVSLRCRELEI-IINHNRAENVQSCDTQVSSLLDGVVTMTSR 1029
Query: 2033 GNQEQLVTVM----EERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNS 2088
G + + V EE I VE K+ + E+ Q EQ+ L HL S T SS +
Sbjct: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ--EQLIL-DHLPSVTKESSLRA 1086
Query: 2089 S 2089
+
Sbjct: 1087 T 1087
Score = 81.3 bits (199), Expect = 9e-15
Identities = 317/1639 (19%), Positives = 657/1639 (40%), Gaps = 226/1639 (13%)
Query: 85 LSNEEHF----QEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEAR 140
+ + +HF +P+ SLE Q + R + + +E +E+F E +E +EE +
Sbjct: 2170 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE--ELENKNEEVQ 2227
Query: 141 PSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDL----NASQSGSSPPQDWIEEKLQEV 196
H+ + + T R +E E E +L + + L S + S+ Q + K ++
Sbjct: 2228 QLHMQL-EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2286
Query: 197 CEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG 256
++ + D LN + V+ +Q D +++EE + L D +E L +
Sbjct: 2287 IQEKEVEID-QLNEQ--VTKLQQQLKITTDNKVIEEK-NELIRDLETQIE----CLMSDQ 2338
Query: 257 KSLTPSASTPYRQLKRHLS--MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGH-ASV 313
+ + + QL + Q G++T+ ++ S + LD + ++
Sbjct: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
Query: 314 ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENE-------LLVTKNSIHQA 366
E+ ++T EE + + +LK +F ++ LT+ +L+ E + +NS++ A
Sbjct: 2399 EQQVETANEE-MTFMKNVLKETNFKMN---QLTQELFSLKRERESVEKIQSIPENSVNVA 2454
Query: 367 ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 426
+D + ++K +L L + + LKSL E + + E + ++
Sbjct: 2455 ---------------IDHLSKDKPELEVVLTE-DALKSL---ENQTYFKSFEENGKGSII 2495
Query: 427 KLDE---EYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSL 483
L+ + + ++A EL + +QI + + E E +K + + +++A +L
Sbjct: 2496 NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAAL 2555
Query: 484 KENSRLENELLENAEKLAEYENLTNKLQR-NLENVLAEKFGDLDPSSAEFFLQEERLTQM 542
+LE + E A+ + + ++++ +R N++N+ + +L + L+ L
Sbjct: 2556 VSQIQLE-AVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQ 2614
Query: 543 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 602
E + ++QV+ + + E K E++ G E + +
Sbjct: 2615 VVEMHTSLILEKEQVEIAEKNVLE------------KEKKLLELQKLLEGNEKKQREKEK 2662
Query: 603 ECNPLNMSI---EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 659
+ +P ++ + EL + ++ LR E + +L +K QE
Sbjct: 2663 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT----KAELASYKEKAEKLQEE 2718
Query: 660 MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
+ + N T +L+K +S +++ +AE + + ++L++ E +E KK E
Sbjct: 2719 LLVKETNMT-SLQKDLSQVRDHLAEAKEKLSILEK---EDETEVQESKKACM--FEPLPI 2772
Query: 720 HLQEKLRLQHEMELKARLTQAQASFEREREG----LQSSAWTEEKVRGLTQ------ELE 769
L + + Q + LK + + G LQS +EE ++Q +++
Sbjct: 2773 KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2832
Query: 770 QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQE-GREKMETEC--NRRTSQIEAQFQS 826
+ H ++ + +H E E L++E Q +E G K +C ++ S I S
Sbjct: 2833 ELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHS 2892
Query: 827 DCQKVTERCESALQSLEGR----YRQELKDLQEQQREEKSQW---EFEKD------ELTQ 873
D + E C S S G+ + D+ + R E+S+ F K +
Sbjct: 2893 DAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHN 2952
Query: 874 ECAEAQELLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSM--VVERQQLLQDLEDLRN 930
E + L + + S+ E + E K Y ++S+ ++ + QL ++ E + +
Sbjct: 2953 EGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYD 3011
Query: 931 VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLA---SQRLERLEMEHDQERQ 987
S++ +S SD EL + ++ E VL A +E A + + L + ++
Sbjct: 3012 SSQSHES-FSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE 3070
Query: 988 EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP-LSMLQSGCQVIG 1046
+ + AME + KA + E + +++ + +K Q++ P +L+ Q
Sbjct: 3071 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ 3130
Query: 1047 EEEVEGDGALSLLQ-QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1105
+ +E LS ++ + +L E+ + + + + +++ T + + L++LE
Sbjct: 3131 SQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE 3190
Query: 1106 P-GLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL-----SDLEDDEVR 1159
L + DE +T +Q ++++++ + + + +E+
Sbjct: 3191 AFRLEVKDKTDE--VHLLNDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELE 3243
Query: 1160 DLGSTGTSSVQR----------QEVKIEESEASVEGFSELENSEETRTESWELKNQISQL 1209
DL + S QR Q+ + ES+ +E L +++ + + L+ Q+
Sbjct: 3244 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLE 3303
Query: 1210 QEQLMM--LCADCDRASEKKQDL------------LFDVSVLKKKLKMLERIPEASPKYK 1255
E++ + + + DR E L L +LK+ K LE + S +
Sbjct: 3304 SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEE--KHSRIVE 3361
Query: 1256 LLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEK 1315
LL E + D LQ +M + R + K L E + KKM E+ L++
Sbjct: 3362 LLNETEKYKLDSLQTRQQMEKDRQ----VHRKTLQTEQEANTEGQKKMHELQSKVEDLQR 3417
Query: 1316 SYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
+E + + +L++ RLQG +++ Q+ ++R E E+ I LN+
Sbjct: 3418 QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER------EEKRESRRI----LYQNLNEP 3467
Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKA------HEIAWLHGTIQTHQERP 1429
+ R+ + V+++ K E + E N L ++ HE+ + +Q +
Sbjct: 3468 TTWSLTSDRTRNWVLQQ-KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3526
Query: 1430 RVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLS 1489
+V Q E + Q I E+ L+ LQ+LT + E +++ S
Sbjct: 3527 QVLPQKASERLQFETADDEDFIWVQENIDEIILQ---LQKLTGQQGEEPSLV---SPSTS 3580
Query: 1490 HGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE------- 1542
G E L ++Q EL + S+ L +E + LRN + L E+
Sbjct: 3581 CGSLTERL-------------LRQNAELTGHISQ-LTEEKNDLRNMVMKLEEQIRWYRQT 3626
Query: 1543 ----DSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
D+ S L + S++E+W + E +QK ++ + ++ +LK
Sbjct: 3627 GAGRDNSSRFSLNGGANIEAIIASEKEVWNR------EKLTLQKSLKRAEAEVYKLK--- 3677
Query: 1593 QQLDLENTELSQKNSQNQE 1611
+L N L Q S + E
Sbjct: 3678 --AELRNDSLLQTLSPDSE 3694
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 153 bits (387), Expect = 1e-36
Identities = 411/2099 (19%), Positives = 801/2099 (38%), Gaps = 421/2099 (20%)
Query: 329 QEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVRE 388
+E+ KA + L + LENEL + + S + EI L ++++Q RE
Sbjct: 71 EEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRE 130
Query: 389 KEKLRSDLDKAEKLKSLMA---SEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 445
E + +L+K +K+ +A E ++ ++ + R N+ L+K +E+ + I + ++
Sbjct: 131 LEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENK-RLKKKNEQLCQDIIDYQKQIDS 189
Query: 446 EREQILQQAG----------KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLE 495
++E +L + G K+ EL Q +++ +T +++ + +E + E ++
Sbjct: 190 QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE-ANEKIEVQNQEMRKNLEESVQ 248
Query: 496 NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM---RNEYERQCRV 552
EK+ + N + +NV+ + L + + LQ + LT + +NE + V
Sbjct: 249 EMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQLQVQELTDLLKSKNEEDDPIMV 304
Query: 553 -LQDQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 604
+ +V+E + E+ EY+ LR LKN+ + ++N ++ +
Sbjct: 305 AVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQI 364
Query: 605 NPLNMSIEA--------ELVIEQMK-------------EQHHRDICCLRLELEDKVRHYE 643
L +E +IE +K +Q H I L++K + E
Sbjct: 365 KMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAE 424
Query: 644 KQ-------------------------------LDETVVSCKKAQENMKQRHEN------ 666
+ L++ VV K + +K R
Sbjct: 425 RTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTK 484
Query: 667 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEAT-CRHEEEKKQLQVKLEEEKTHLQEKL 725
E + LE +ISD +E L+ + + + + T R+ + KQ Q + E + + +
Sbjct: 485 EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIES 544
Query: 726 RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ---FHQEQLTSLVEK 782
+ ++LK ++ Q ER + S TE+ LT+ + Q + +L L K
Sbjct: 545 LEEERLDLKKKIRQMAQ--ERGKRSATSGLTTEDL--NLTENISQGDRISERKLDLLSLK 600
Query: 783 HTLE----KEELRKELLEKHQRELQEGREKMETECNR------RTSQIEAQFQSDCQKVT 832
+ E E L +EL+EK +R+L+ R + N+ Q+E + Q +
Sbjct: 601 NMSEAQSKNEFLSRELIEK-ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK 659
Query: 833 ER-----------------CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
E E + ++E + + + D + + Q +EL QE
Sbjct: 660 EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719
Query: 876 AEA--------QELLKETLK---REKTTSLVLTQEREML--------------------- 903
E+ Q+L K LK EK TSL+ E +
Sbjct: 720 RESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINS 779
Query: 904 EKTYKEHLNSMVVERQQLLQDLEDLRN-------VSETQQSLLSDQILELKSSHK----- 951
+ Y HL + +++ L++LED V QQSLL + L K + K
Sbjct: 780 QNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKT 839
Query: 952 --RELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATC-ETAD 1008
E R+ E+ + Q + + L L+M+ D+ M K+LA EN K T + +
Sbjct: 840 IKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDE-----MKKILA-ENSRKITVLQVNE 893
Query: 1009 RERAEMSTEISRLQSKIKEM--QQATSPLSMLQSGCQVIG----------------EEEV 1050
+ T + L+ ++++ +Q LSM C+ IG ++ V
Sbjct: 894 KSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
Query: 1051 EGDGALS------------------LLQQGEQLLEE---------------------NGD 1071
+ +LS +LQ+ L++ N +
Sbjct: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKE 1013
Query: 1072 VLLSLQRAH--EQAVKENVKMATEISRLQQR----------LQKLEPGLVMSSCLDEPAT 1119
+ ++ ++ H EQA ++ K+ E S + + + K L M +
Sbjct: 1014 LEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRA 1073
Query: 1120 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE----------DDEVRDLGSTGTSSV 1169
E E L+Q + E T+ L+ + DE+ D S S
Sbjct: 1074 EHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133
Query: 1170 QRQ---EVKIEESEASVEGFSELENSEETRTESWELKNQISQLQ----EQLMMLCADCDR 1222
RQ E++ E E VE S+L + E+ N Q + E L M D
Sbjct: 1134 DRQRILELEKNEMELKVE-VSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
Query: 1223 ASEKKQDLL----FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1278
S++K + +VS+ + L ++ + K + + R L E+ + +
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252
Query: 1279 YDEALENNKELTAEVFRLQDE------LKKMEEVTETFLSLEKSYDEVKI---------E 1323
E K L + L+ + L + E+ ++T + L+ D++KI E
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQE 1310
Query: 1324 NEELNVLVLRLQGKIEKLQESVVQRCDC------CLWEASLENLEIEPDGNILQLNQTLE 1377
+ + L ++ K++ L+E + D W +E L ++ L+LN+ L
Sbjct: 1311 HRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE----LKLNRELV 1366
Query: 1378 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE---IAWLHGTIQTHQERPRVQNQ 1434
+ ++ ++++I E ++ LE +++++ K HE +AW + + Q
Sbjct: 1367 KDKEEIKYLNNIISEYERTISSLE--EEIVQQNKFHEERQMAWDQREVDLER-----QLD 1419
Query: 1435 VILEENTTLLGFQDKHFQHQATIAELELE-KTKLQELTRKLKERVTILVKQKDVL-SHGE 1492
+ + +L K + +I + L +L+ RK+KE + I+++ + S E
Sbjct: 1420 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEE 1479
Query: 1493 KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG- 1551
K +E ++ + + + + LR + ++ E S LK+
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539
Query: 1552 -TLNGSQEEMWQKTETVKQENAAVQKMVEN----LKKQISELKIKNQQLDLENTELSQKN 1606
T+ Q + QK E +K+ ++K E +KK +L I + +L+L+ K
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKF 1599
Query: 1607 SQNQE-----------------KLQELNQRLTEM------LCQKEKEPGNSALEEREQEK 1643
Q +L E+ Q + E L K K+ +RE +
Sbjct: 1600 KQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITE 1659
Query: 1644 FNLKEELERCKVQ----SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH-RC 1698
+KE E K+Q V ++AE+ ++K Q+E+ LK EL+ K+ + R
Sbjct: 1660 LKVKE-FENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRA 1718
Query: 1699 P--DLSDFQQKISSVLSYNEK-----------LLKEKEALSEE--LNSCVDK---LAKSS 1740
P + + +++ S L+ EK L E A +EE +++ K L
Sbjct: 1719 PTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778
Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800
+++ +K + + LK L S+ + +L D + ++N ++ + + +
Sbjct: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838
Query: 1801 EKEALKQEVMSLHKQLQN-AGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN------- 1852
EKE + QE L +Q++ G P S + Q+++ KL++ +
Sbjct: 1839 EKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK--KLENQLEGKVEEVD 1896
Query: 1853 ---------EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1903
+E+ + W+E ++ Q ++ R K+++ E + ++
Sbjct: 1897 LKPMKEKNAKEELIRWEEGKKWQAKIEGI-------RNKLKEKEGEVFTLTKQLNTLKDL 1949
Query: 1904 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL 1963
++EKL+L+R+ K +V + +LE E E E LKK+ + L+ +
Sbjct: 1950 FAKADKEKLTLQRKL----KTTGMTVDQVLGIRALESEKEL-----EELKKRNLDLENDI 2000
Query: 1964 MEMQ--------------HLRSTATPSPSPHAWDLQLLQQ----------QACPMVPREQ 1999
+ M+ HL++ HA + Q + ++ REQ
Sbjct: 2001 LYMRAHQALPRDSVVEDLHLQNRYL-QEKLHALEKQFSKDTYSKPSISGIESDDHCQREQ 2059
Query: 2000 FLQLQRQLLQAERINQHLQEELENR-TSETNTPQGNQEQLVTVMEERMIEVEQKLKLVK 2057
LQ + L +E I Q E N+ + +++ +++ EV++KL V+
Sbjct: 2060 ELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVR 2118
Score = 149 bits (375), Expect = 4e-35
Identities = 301/1518 (19%), Positives = 645/1518 (42%), Gaps = 195/1518 (12%)
Query: 310 HASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALA 369
H E I Q E I EI K +++ E L E+ + K SI + +
Sbjct: 995 HLECENISLKEQVESINKELEITKEKLHTIEQAWE-QETKLGNESSMDKAKKSITNSDIV 1053
Query: 370 SFKAEIRHL-------LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNE 422
S +I L +R + + E LR+ L + E+ E++ A + + N
Sbjct: 1054 SISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF----ELETKFAELTKIN- 1108
Query: 423 YNLRKLDEEYKERIA--ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
+ +K+++ ++ +A K +R++IL+ K +EL+ E+ K + + R ++
Sbjct: 1109 LDAQKVEQMLRDELADSVSKAVSDADRQRILELE-KNEMELKVEVSKLREISDIARRQVE 1167
Query: 481 LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
+ + + E+ +L +Y+ ++ +++L L + L S A + E +T
Sbjct: 1168 ILNAQQQSRDKEVESLRMQLLDYQAQSD--EKSLIAKLHQHNVSLQLSEATALGKLESIT 1225
Query: 541 QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 600
+ E L+ ++DE + L R +GR L+ + + + G P
Sbjct: 1226 SKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT-IQSLRRQFSGALPLAQQE 1284
Query: 601 SEECNPLNMSIEAELVIEQMK--EQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
+ + + ++++MK +Q HR++ LE+E K++ E +L T+ K AQ+
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE-ELISTLKDTKGAQK 1343
Query: 659 NMKQRHENETHTLEK------------QISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 706
+ + E L++ +I L N I+E + + L+E + HEE
Sbjct: 1344 VINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEER 1403
Query: 707 KKQLQVKLEEEKTHLQEKL----RLQHEMELKARL----------------TQAQASFER 746
Q+ ++ + L+ +L R Q+E+ A+ Q + + +
Sbjct: 1404 ----QMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 1459
Query: 747 EREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL-------LEKHQ 799
+E ++ T + L ++L++ +E L E++ L ++++ EL E+ +
Sbjct: 1460 IKENIRIILETRATCKSLEEKLKE--KESALRLAEQNILSRDKVINELRLRLPATAEREK 1517
Query: 800 RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
+ GR++ME + + T +I Q ++ Q + E L+ +Y++ L+ +E+QRE
Sbjct: 1518 LIAELGRKEMEPK-SHHTLKIAHQTIANMQARLNQKEEVLK----KYQRLLEKAREEQRE 1572
Query: 860 EKSQWEFE------------KDELTQECAEAQELLKETLKREKTTS-LVLTQEREMLEKT 906
+ E + L + A +L+K++ T + E E
Sbjct: 1573 IVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAE 1632
Query: 907 YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH-------KRELREREE 959
+ L+S++V+ +++ QDLE R ++E + + L+L+ +H K E+ + +
Sbjct: 1633 QDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKY 1692
Query: 960 VLCQAGASEQLASQRLERLEMEHDQER--------QEMMSKLLAMENIHKATCETADRER 1011
+L Q+ Q L+ + + + + + S+L E KA R
Sbjct: 1693 LLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELR 1752
Query: 1012 AEMS--------TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGE 1063
AEM+ + S+ ++ + Q L++ + + E ++ AL + E
Sbjct: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812
Query: 1064 QLLEEN----GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPAT 1119
L +N + L Q+A+ + ++E ++ E L++++++L GL +P T
Sbjct: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQ-----GKPLT 1867
Query: 1120 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDL------GSTGTSSVQRQE 1173
+ + E+ + +++ Q+EG L +++ ++ G + ++
Sbjct: 1868 DNKQSLIEELQRKVKKLEN-QLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIR 1926
Query: 1174 VKIEESEASVEGFSELENS---------EETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
K++E E V ++ N+ +E T +LK + + L + + ++
Sbjct: 1927 NKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKEL 1986
Query: 1225 E--KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1282
E KK++L + +L R +A P+ ++ ED+ +N LQE+L +E ++ +
Sbjct: 1987 EELKKRNLDLENDILYM------RAHQALPRDSVV-EDLHLQNRYLQEKLHALEKQFSKD 2039
Query: 1283 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1342
+ ++ D ++ +E+ + L L E+K + E+ N + RL+ ++ L+
Sbjct: 2040 TYSKPSISG--IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLK 2097
Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYL-- 1400
E C+ E + ++ + +T+ E + + V+E+ ++EN+ L
Sbjct: 2098 EM----CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKK 2153
Query: 1401 --------------EGNTQL---LEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1443
+ N +L LEK+KAH L + H E + I+ EN L
Sbjct: 2154 ASGILTSEKMANIEQENEKLKAELEKLKAH----LGHQLSMHYESKTKGTEKIIAENERL 2209
Query: 1444 LGFQDKHFQHQATIAE-LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMH 1502
K + + AE L + K L+ L E++T+ +++ G++ + ++
Sbjct: 2210 R----KELKKETDAAEKLRIAKNNLEILN----EKMTVQLEET-----GKRLQFAESRGP 2256
Query: 1503 DLQITCSEMQQKVELLR-YESEKLQQENSILRNE--ITTLNEEDSISNLKLGTLNGSQEE 1559
L+ S+ + + + R YE++ + E I + IT L + + + +N E+
Sbjct: 2257 QLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNED 2316
Query: 1560 MWQKTETVKQ--ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL-QEL 1616
+ Q+ + +K E A + + LK+++ L++ N QLD E EL + N+++ E
Sbjct: 2317 LEQQIKILKHVPEGAETE---QGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373
Query: 1617 NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1676
+ L +K K+ + L+ + EK +LKEE+++ K + S E+ ++K
Sbjct: 2374 TIPDADQLKEKIKDL-ETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYK 2432
Query: 1677 IVQQENHLLKDELEKMKQ 1694
++N LL+++++K+ +
Sbjct: 2433 EEVKKNILLEEKVKKLSE 2450
Score = 148 bits (373), Expect = 6e-35
Identities = 333/1715 (19%), Positives = 699/1715 (40%), Gaps = 262/1715 (15%)
Query: 441 NELRKERE----------QILQQAGKQRLELE-QEIEKAKTEENYIRDRLALSLKENSRL 489
NEL+ E++ Q L + Q +EL +E+EKA E+ ++L + +L
Sbjct: 38 NELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVM---KL 94
Query: 490 ENELLENAEKLA---EYENLTNKLQRNLENVLAEKFGDLDPSSAEF----------FLQE 536
ENEL E A++ A + L N++ + LE L +K +L+ E L+
Sbjct: 95 ENEL-EMAQQSAGGRDTRFLRNEICQ-LEKQLEQKDRELEDMEKELEKEKKVNEQLALRN 152
Query: 537 ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
E ++ R+ + L+ + ++L ++ +Y+ Q + L + E+ + S +
Sbjct: 153 EEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKN 212
Query: 597 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
+ L + + + EA IE ++ +R LE+ V+ EK DE
Sbjct: 213 YEL-IQYLDEIQTLTEANEKIEVQNQE-------MRKNLEESVQEMEKMTDEY-----NR 259
Query: 657 QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE------ATCRHEEEKKQL 710
+ + + +N L+K+ + ++ EL +LK + E A EE K +
Sbjct: 260 MKAIVHQTDNVIDQLKKENDHYQLQVQELTD---LLKSKNEEDDPIMVAVNAKVEEWKLI 316
Query: 711 QVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 770
++E Q+ L E A+L +++ ++G+Q + +++ LT+++EQ
Sbjct: 317 LSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER---DSQIKMLTEQVEQ 373
Query: 771 FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK 830
+ +E +EK+T E+L+ EL R K + +++T ++
Sbjct: 374 YTKE-----MEKNTCIIEDLKNELQ----------RNKGASTLSQQTHMKIQSTLDILKE 418
Query: 831 VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREK 890
T+ E + E R++ K+L E + K ++E E A + +K K
Sbjct: 419 KTKEAERTAELAEADAREKDKELVEALKRLK---DYESGVYGLEDAVVE------IKNCK 469
Query: 891 TTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH 950
+ +E E+L K +N + ++ L + E LR + + D S H
Sbjct: 470 NQIKIRDREIEILTK----EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKH 525
Query: 951 KRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL--LAMENIHKATCETAD 1008
++ + R E Q+ + +E LE +ER ++ K+ +A E ++
Sbjct: 526 LKQQQYRAE--------NQILLKEIESLE----EERLDLKKKIRQMAQERGKRSATSGLT 573
Query: 1009 RERAEMSTEISRLQSKIKEMQQ---ATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
E ++ IS+ +I E + + +S QS + + E +E E+
Sbjct: 574 TEDLNLTENISQ-GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK----------ERD 622
Query: 1066 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS---SCLDEPATEFF 1122
LE + V+ Q ++ V+EN ++ + + Q +++++ + + L P+ E
Sbjct: 623 LERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERL 682
Query: 1123 GNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1182
N E +K EG+ + + D++ TG + RQE++ ES
Sbjct: 683 VNAIE----------SKNAEGIFDASLHLKAQVDQL-----TGRNEELRQELR--ESRKE 725
Query: 1183 VEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRA-----------SEKKQDLL 1231
+S+ + + E + + + E ++ D + + + L+
Sbjct: 726 AINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785
Query: 1232 FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTA 1291
+ L+ K K L+ + ++ Y + + + L Y E L +
Sbjct: 786 HLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL----------YKEYLSEKETWKT 835
Query: 1292 EVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDC 1351
E +++E +K+E+ + D +K++ E N L+ LQ +++++ + +
Sbjct: 836 ESKTIKEEKRKLEDQVQQ--------DAIKVK--EYNNLLNALQMDSDEMKKILAEN--- 882
Query: 1352 CLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1411
+ L++ I Q TL E ++R E KQ+N+ L ++ EK+
Sbjct: 883 ---SRKITVLQVNEKSLIRQYT-TLVELERQLRK-----ENEKQKNELLSMEAEVCEKI- 932
Query: 1412 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1471
G +Q +E + + K + +++ELEL + ELT
Sbjct: 933 --------GCLQRFKEMAIFKIAAL-----------QKVVDNSVSLSELELANKQYNELT 973
Query: 1472 RKLKE---RVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKVELLRYESE 1523
K ++ + +LV++ L H E E E+++++ +L+IT ++ + E
Sbjct: 974 AKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKL--------HTIE 1025
Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
+ ++ + L NE + + SI+N + +++ + K +Q QKM E+L+
Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085
Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
+ +++ +N +L+ + EL++ N Q+ Q L L + + + + + E E+ +
Sbjct: 1086 SLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNE 1145
Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEV-KIQTHIVQQENHLLKDELEKMK-QLHRCPDL 1701
LK E+ + + E+S++ + Q I+ + E+E ++ QL
Sbjct: 1146 MELKVEVSKLR------------EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQ 1193
Query: 1702 SDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSA 1761
SD + I+ + +N L + +L S KL K R+ EQK E + A
Sbjct: 1194 SDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRL-----EQKLDEKEQA 1248
Query: 1762 SLKSQLVASQEKVQNLEDTVQNVNLQMS---------RMKSDLRVTQQEKEALKQEVMSL 1812
++L + + ++L T+Q++ Q S + + Q +K + QE+ +
Sbjct: 1249 LYYARL-EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNS 1307
Query: 1813 HKQLQNAGGKS--------WAPEIATHPSGLHNQQKRLSWD-KLDHLMNEEQQL---LWQ 1860
++ +N K+ E+ + QK ++W K++ L +E +L L +
Sbjct: 1308 QQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK 1367
Query: 1861 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920
+ E ++ + N +E + + LE ++ +++ H +Q ++ L+R+ D
Sbjct: 1368 DKEEIK-YLNNIISEYERT---ISSLEEEIVQQNKFH---EERQMAWDQREVDLERQLDI 1420
Query: 1921 FQKEQSPANRKVSQMNSLEQEL--ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS 1978
F ++Q+ + + ++ L N+ L+ K+ E + + R+T
Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQ-LEIALRKIKENIRIILETRATCKSLEE 1479
Query: 1979 PHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQ--E 2036
L+ ++ R++ + R L A + L EL + E + +
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539
Query: 2037 QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
Q + M+ R+ + E+ LK +RLL++ + +E V
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIV 1574
Score = 139 bits (351), Expect = 2e-32
Identities = 412/2027 (20%), Positives = 815/2027 (40%), Gaps = 328/2027 (16%)
Query: 332 LKALDFSLDGNINLTELTLALENELLVT----KNSIHQAALASFKAEIRHLLERVDQVVR 387
LK DF LD N L E + LE + ++ +NS H ++AE + LL+ ++ +
Sbjct: 491 LKISDF-LDENEALRE-RVGLEPKTMIDLTEFRNSKHLKQ-QQYRAENQILLKEIESLEE 547
Query: 388 E----KEKLRSDLDKAEKLKSLMASEVDDHHAA--IERRNEYNLRKLDEEYKERIAALKN 441
E K+K+R + K + +D + I + + + RKLD + +LKN
Sbjct: 548 ERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLD------LLSLKN 601
Query: 442 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 501
E + + ++ +E E+++E+++T +++L ++EN +LE + E + +
Sbjct: 602 --MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK 659
Query: 502 EYEN-----------LTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 550
E + + L+R + + ++ + +S Q ++LT E ++
Sbjct: 660 EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719
Query: 551 RVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANS---GGIEPEHGLGSEECNPL 607
R + + +L +A ++ L + S + E ++ GI+ G+ + +
Sbjct: 720 RESRKEAINYSQQLA--KANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASII 777
Query: 608 NMSIEAELVIEQMKEQHHRDICCLRLELEDK------VRHYEKQLDETVVSCKKAQENMK 661
N E + + Q E + + L LED +RH + L + +S K+ +
Sbjct: 778 NSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTES 837
Query: 662 QRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT-- 719
+ + E LE Q+ ++ E L+ E E +++ V EK+
Sbjct: 838 KTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
Query: 720 -------HLQEKLRLQHE------MELKARLTQAQASFERERE----------------- 749
L+ +LR ++E + ++A + + +R +E
Sbjct: 898 RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957
Query: 750 GLQSSAWTEEKVRGLTQELEQFHQE-----QLTSLVEKHTLEKEELRKELLEKHQRELQE 804
L ++ LT + Q+ Q TS +E E L KE +E +EL+
Sbjct: 958 SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISL-KEQVESINKELEI 1016
Query: 805 GREKMETECNRRTSQIEAQFQSDCQKVTERC-ESALQSLEGRYRQ-ELKDLQEQQREEKS 862
+EK+ T + + +S K + S + S+ + E+K+L E+QR E
Sbjct: 1017 TKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAE-- 1074
Query: 863 QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLL 922
C + E L+ +LK+ + + L E + E T K +L++ VE Q L
Sbjct: 1075 -----------HCQKMYEHLRTSLKQMEERNFEL--ETKFAELT-KINLDAQKVE-QMLR 1119
Query: 923 QDLEDLRNVSETQQSLLSDQILELKS---------SHKREL----REREEVLC--QAGAS 967
+L D +VS+ +ILEL+ S RE+ R + E+L Q
Sbjct: 1120 DELAD--SVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRD 1177
Query: 968 EQLASQRLERLEMEHDQERQEMMSKLLAME---NIHKATC----ETADRERAEMSTEISR 1020
+++ S R++ L+ + + + +++KL + +AT E+ + +M R
Sbjct: 1178 KEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLR 1237
Query: 1021 LQSKIKEMQQAT-----SPLSMLQSGCQVIGEEEVEGDGALSLLQQ---GEQLLEENGDV 1072
L+ K+ E +QA + + Q I + GAL L QQ + +++ D
Sbjct: 1238 LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDK 1297
Query: 1073 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1132
L +Q + + +E+ M + ++ +L+ LE ++S+ D + N + E
Sbjct: 1298 LKIMQEM-KNSQQEHRNMENKTLEMELKLKGLEE--LISTLKDTKGAQKVINWHMKIEEL 1354
Query: 1133 LQQNRTKQVEGVTRRH---VLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1189
Q E V + L+++ + R + S VQ+ + E A + +L
Sbjct: 1355 RLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDL 1414
Query: 1190 ENS--------EETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL 1241
E E + + + + + + L + A K ++ + + +
Sbjct: 1415 ERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATC 1474
Query: 1242 KMLE-RIPEASPKYKLLYEDVSRENDCLQE-ELRMMETRYDEALE---NNKELTAE---- 1292
K LE ++ E +L +++ + + E LR+ T E L KE+ +
Sbjct: 1475 KSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHT 1534
Query: 1293 -------VFRLQDELKKMEEVTETFLSL-EKSYDE----VKIENEELNVLVLRLQGKIEK 1340
+ +Q L + EEV + + L EK+ +E VK E+L++L RL E
Sbjct: 1535 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL----EL 1590
Query: 1341 LQESVVQRCDCCLWEASLEN-LEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
+S + + W+ ++ + + + ++L + + + S+ ++ + K+ +Q
Sbjct: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQD 1650
Query: 1400 LEGNTQLLE-KVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
LE ++ E KVK E L E +V+ +V E+ LL K + Q +
Sbjct: 1651 LERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV--EDLKYLLDQSQK--ESQCLKS 1706
Query: 1459 ELELEK--------TKLQELTRKLKERVTILVKQKDVLSHG--EKEEELKAMMHDLQITC 1508
EL+ +K T ++ L +LK ++ + KQ+ LS E E+ A + I+
Sbjct: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISA 1766
Query: 1509 SE-------MQQKVEL----LRYESEKLQQENSILRNEI-TTLNEEDSISNLKLGTLNGS 1556
+ +QQ V+ L+ + E L + L+ + T+ N E+S+++ L LN
Sbjct: 1767 TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTD-NLNDLNNE 1825
Query: 1557 QEEMWQKTETVKQENAAVQKMVENLKKQISELK--------IKNQQLDLENTELSQKNSQ 1608
++ + + +E + + + LK+QI L N+Q +E + K +
Sbjct: 1826 LQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
Query: 1609 NQ--EKLQELNQRLTEMLCQKEK--------------EPGNSALEEREQEKFNLKEELER 1652
NQ K++E++ + + KE+ E + L+E+E E F L ++L
Sbjct: 1886 NQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNT 1945
Query: 1653 CK---VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-ELEKMKQLHRCPDLSDFQQKI 1708
K ++ +L+ +L + V L + ELE++K+ + + +
Sbjct: 1946 LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005
Query: 1709 SSVL---SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKS 1765
L S E L + L E+L++ + +K + + I+ ++ + Q K
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ-KE 2064
Query: 1766 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA 1825
L S E ++ L+ ++ N + R+K+ +R ++ E LK+E + ++L + G +
Sbjct: 2065 NLKLSSENIE-LKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS 2123
Query: 1826 ----PEIATHPSGLHN-----QQKRLSWDKLDHLMNEEQQL-LWQENERLQTMVQNTKAE 1875
PE+ + Q++ K ++ E+ + QENE+L+ ++ KA
Sbjct: 2124 GKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAH 2183
Query: 1876 LTH--------------------------------SREKVRQLESNL----------LPK 1893
L H + EK+R ++NL L +
Sbjct: 2184 LGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEE 2243
Query: 1894 HQKHLNPSGTMNP---------------TEQEKLSLKR-ECDQFQKEQS----------- 1926
K L + + P T + LK E D +K QS
Sbjct: 2244 TGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEA 2303
Query: 1927 -PANRKVSQMN-SLEQELETIHLENEGLKKKQ-VKLDEQLMEMQHLRSTATPSPSPHAWD 1983
+KV++ N LEQ+++ + EG + +Q +K + Q++ + + + + H +
Sbjct: 2304 TEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIE 2363
Query: 1984 LQLLQQQACPMVP-----REQFLQLQRQLLQAERINQHLQEELENRTSE-TNTPQGNQEQ 2037
Q A +P +E+ L+ QL ++ QHL+EE++ E N E+
Sbjct: 2364 ANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEE 2423
Query: 2038 LVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHS 2084
+ + EV++ + LL+EKV +L EQ+ + L SP + S
Sbjct: 2424 IEDLKYNYKEEVKKNI-----LLEEKVKKLSEQLGV--ELTSPVAAS 2463
Score = 95.5 bits (236), Expect = 5e-19
Identities = 226/1145 (19%), Positives = 463/1145 (40%), Gaps = 218/1145 (19%)
Query: 313 VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 372
+ER LD + + EIL A + ++ + +L L N+L + AL K
Sbjct: 1414 LERQLDIFDRQ----QNEILNAAQKFEEATGSIPDPSLPLPNQL--------EIALRKIK 1461
Query: 373 AEIRHLLER------VDQVVREKE------------------KLRSDLDKAEKLKSLMAS 408
IR +LE +++ ++EKE +LR L + + L+A
Sbjct: 1462 ENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIA- 1520
Query: 409 EVDDHHAAIERRNEYNLRKLDEEYKERIAAL--KNELRKEREQILQQAGKQRLELEQEIE 466
+ +E ++ + L+ + A L K E+ K+ +++L++A +++ E+ ++
Sbjct: 1521 --ELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREI---VK 1575
Query: 467 KAKTEENYIRDRLAL----SLKENSRLENELLENAE----------KLAEYENLTNKLQR 512
K + + + + RL L SL + + +L++ + +LAE E +
Sbjct: 1576 KHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDD 1635
Query: 513 NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ----DQVDELQSELEEYR 568
+L ++L + L S + Q E E+E LQ D+V ++++E+E+ +
Sbjct: 1636 SLSSLLVK----LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLK 1691
Query: 569 A---QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 625
Q + LK+ + EANS + L ++++L + KE+
Sbjct: 1692 YLLDQSQKESQCLKSELQAQKEANSRA-------PTTTMRNLVERLKSQLAL---KEKQQ 1741
Query: 626 RDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAEL 685
+ + LEL ++ ++ + S K+A N++Q + T L+ Q+ DL + +L
Sbjct: 1742 KALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKL 1801
Query: 686 QGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFE 745
+ K + T + +LQ K + L+EK + E + + + +
Sbjct: 1802 KEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEND------ELKRQIK 1855
Query: 746 REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 805
R GLQ T+ K SL+E ELQ
Sbjct: 1856 RLTSGLQGKPLTDNK----------------QSLIE-------------------ELQRK 1880
Query: 806 REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG-RYRQELKDLQEQQREEKSQW 864
+K+E + + +++ + K E ++ EG +++ +++ ++ + +E+
Sbjct: 1881 VKKLENQLEGKVEEVDLK----PMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK---- 1932
Query: 865 EFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD 924
E E LT++ LK+ + L L ++ + T + L +E ++ L++
Sbjct: 1933 EGEVFTLTKQL----NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEE 1988
Query: 925 LE----DLRN---VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER 977
L+ DL N Q+L D ++E R L+E+ L + + + + +
Sbjct: 1989 LKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISG 2048
Query: 978 LEM-EHDQERQEMMSK--LLAMENIH----------------------KATCETADRERA 1012
+E +H Q QE+ + L+ ENI K CE +E+A
Sbjct: 2049 IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKA 2108
Query: 1013 EMSTEISRLQSK------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL------SLLQ 1060
E+ ++ ++ I E+++ + + Q E+ + G L ++ Q
Sbjct: 2109 EVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168
Query: 1061 QGEQLLEE----NGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDE 1116
+ E+L E + L +E K K+ E RL++ L+K +
Sbjct: 2169 ENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-----------ET 2217
Query: 1117 PATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV---QRQE 1173
A E A+ L + T Q+E +R ++ ++ S S+ + E
Sbjct: 2218 DAAEKL-RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE 2276
Query: 1174 VKIEESEASV----EGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQD 1229
K++E E + + ++L+ + TE + N+ ++ EQ + + +E +Q
Sbjct: 2277 TKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG 2336
Query: 1230 LLFDVSVL--------KKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
L ++ VL K+K +++ +I EA+ K + E + D L+E+++ +ET+
Sbjct: 2337 LKRELQVLRLANHQLDKEKAELIHQI-EAN-KDQSGAESTIPDADQLKEKIKDLETQL-- 2392
Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETF-LSLEKSYDEVKIENEELNVLVLRLQGKIEK 1340
K E L++E+KK+++ E F S + +++K +E + L+ K++K
Sbjct: 2393 -----KMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447
Query: 1341 LQESV 1345
L E +
Sbjct: 2448 LSEQL 2452
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 153 bits (387), Expect = 1e-36
Identities = 224/1134 (19%), Positives = 499/1134 (44%), Gaps = 120/1134 (10%)
Query: 760 KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
KV+ L Q Q + Q ++ L+K + R++ E +EL++ ++ E N Q
Sbjct: 847 KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 820 IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 877
++A+ + ++ +++ R + Q LE E++ E++ + Q + E+ ++ Q+ +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 878 AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 930
+E L+E L+ EK T+ ++ E + N + ER+ L + + DL N
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 931 VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 990
++E ++ + + +LK+ H+ + E E L E+ + Q LE+L+ + + + +
Sbjct: 1022 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 991 SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1049
++ ++ I + + A +E E+ ++RL +I + A + L+ I + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1131
Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
+ D + + E+ + G+ L +L+ E + ++ + R ++ + V
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1185
Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1162
+ LDE E + Q + T+Q+E R D LE + G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 1163 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
+QEV K ++ EA V+ S+ + E R EL +++ +LQ ++ +
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1302
Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1279
+ A K L DV+ L +L+ + + + + KL +VS + L+EE ++ +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1359
Query: 1280 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1332
DE +E + L + +L D KK+++ T +LE+ + E E L
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1390
K+EK + + Q D + L+N + + N+ + + ++ + +++ +
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1449
E + E + E T+ L +A E A ++ +E R N+++ E L+ +D
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1530
Query: 1450 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1490
+A ++E KT+L+EL T K R+ + ++ ++D+ +
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590
Query: 1491 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1544
E+ EE L+ +H+ + + +++ L +KL+ + + L+ + E++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 1545 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
I L+ L S++E++ + +++ +++ + L++ ++ +
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 1593 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1649
+Q DLE EL+++ + + LQ+ +RL + Q E+E LEE + + +
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1765
Query: 1650 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1703
+ + Q+ L + L E S + QQ +N L+ +L +M+ + ++
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
+ KI+ + E+ +EK+A ++ L DK K LL+ + ++ + ++ Q+
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1882
Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
+++ + +++ E+ Q +N +++ +L + EA+ +EV +L +L+
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 147 bits (371), Expect = 1e-34
Identities = 251/1125 (22%), Positives = 481/1125 (42%), Gaps = 189/1125 (16%)
Query: 351 ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
A E+EL TK +A + E++ L ++ Q+ EK L+ L +L + A E+
Sbjct: 863 AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 916
Query: 411 DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 459
AA ++ E L +++ EE ++R L+ E +K +Q+L ++A +Q+L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 460 ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 508
+LE+ +AK ++ + D + + +N++L E +LLE AE+ + +NLT
Sbjct: 977 QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1033
Query: 509 KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 564
KL+ E++++E + + S E + +L +++ Q LQ Q+ EL+ +L
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 565 -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 604
+E Q + RL KN+ +++ G I + + L SE
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 605 ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
L ++++ ++++ + +++ L+ L+++ R +E Q+ E +A E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 659 NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
+ ++ E L+K L+ E A+L G+ VL +A E E +KK+L+ +++
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1269
Query: 716 E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 753
E + L +K+ +LQ+E+E + L +A+ AS + + Q
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 754 SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
E + + ++ +L Q +E+ SL ++ L++E K+ LE+H L + +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 813 CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 857
S +EA +FQ + + +T++ E L+ + R +QEL DL + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 858 RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 895
R+ EK Q +F++ DE + AEA+E KET L R +L
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1504
Query: 896 LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
+E E K K + +V + + + +LE + ETQ + Q+ EL+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560
Query: 953 ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
EL+ E+ + + Q + ER D++ +E +L + ++ E ++RA
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620
Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
+ +L+ +K+++ LQ+ + G EE ++Q +L + D
Sbjct: 1621 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1664
Query: 1073 LLSLQRAHEQ------AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
L+ A KEN K A L+ L +L+ L + + A A
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKA---KSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGF 1186
E+ L Q E ++ LE++ + G+ S + ++ + + S E
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 1187 SELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1246
+E +++ + +L+ Q +L+ +L + K ++ L+ K+ LE
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH------EMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 1247 IPEASPKYK------LLYEDVSRENDCLQ-EELRMMETRYDEALENNKELTAEVFRLQDE 1299
E + K L +D + LQ E+ R M +Y E E A V +L+ +
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG---NARVKQLKRQ 1892
Query: 1300 LKKMEEVTETF----LSLEKSYDEVKIENE----ELNVLVLRLQG 1336
L++ EE ++ L++ DE NE E+N L +L+G
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937
Score = 145 bits (367), Expect = 3e-34
Identities = 246/1108 (22%), Positives = 460/1108 (41%), Gaps = 172/1108 (15%)
Query: 321 QEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLE 380
+++ EN + L+ L NL + L E EL + + LA+ K E+ +L
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM-RVRLAAKKQELEEILH 932
Query: 381 RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIER----RNEYNLRKLDEEYK--- 433
++ + E+E L +AE+ K MA ++ D +E R + L K+ E K
Sbjct: 933 EMEARLEEEEDRGQQL-QAERKK--MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 434 --ERIAAL---KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 488
+ I + N+L KER+ + ++ L +E EKAK ++ S
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI----SE 1045
Query: 489 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 548
LE L + + E E L KL+ + + E+ DL AE +Q L + E +
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQ---LAKKEEELQA 1101
Query: 549 QCRVLQDQVDELQSELEEYRA-QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
L D++ + + L++ R +G + L+ E A + + + LG EE L
Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLG-EELEAL 1158
Query: 608 NMSIEAEL----VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 663
+E L ++++ + +++ L+ L+++ R +E Q+ E +A E + ++
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 664 HENETHT---LEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE---- 716
E L+K L+ E A+L G+ VL +A E E +KK+L+ +++E
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQELQSK 1274
Query: 717 ------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQSSAWTE 758
+ L +K+ +LQ+E+E + L +A+ AS + + Q E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 759 EKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 817
+ + ++ +L Q +E+ SL ++ L++E K+ LE+H L + +
Sbjct: 1335 TRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 818 SQIEA------QFQSDCQKVTERCESA------LQSLEGRYRQELKDLQ---EQQRE--- 859
S +EA +FQ + + +T++ E L+ + R +QEL DL + QR+
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 860 --EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLVLTQER 900
EK Q +F++ DE + AEA+E KET L R +L +E
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALEAKEEL 1509
Query: 901 EMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 957
E K K + +V + + + +LE + ETQ + Q+ EL+ EL+
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED----ELQAT 1565
Query: 958 EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1017
E+ + + Q + ER D++ +E +L + ++ E ++RA +
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 1018 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQ 1077
+L+ +K+++ LQ+ + G EE ++Q +L + D L+
Sbjct: 1626 KKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDFQRELE 1669
Query: 1078 RAHEQ------AVKENVKMA----TEISRLQQRLQKLEPG-----LVMSSCLDEPATEFF 1122
A KEN K A ++ +LQ+ L E L +E A+
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 1123 GNTAEQTEPFLQQNRTKQVE-----------GVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
G A Q E + R Q+E ++ R + + +++ + +T S+ Q+
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 1172 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL 1231
E ++ E + + E +S + K+ I+ L+ ++ L ++ + +KQ
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 1232 FDVSVLKKKLK-----------MLERIPEASPK-------YKLLYEDVSRENDCLQEELR 1273
+ KKLK M E+ E + K K E+ E+ + R
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 1274 MMETRYDEALENNKELTAEVFRLQDELK 1301
++ DEA E+N+ + EV L+ +L+
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 145 bits (366), Expect = 4e-34
Identities = 245/1200 (20%), Positives = 509/1200 (42%), Gaps = 169/1200 (14%)
Query: 433 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
+E + A ++EL+K +E+ Q+A + ELEQ+ + E+N ++++L + + E
Sbjct: 858 EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 493 LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
+ A K E E + ++++ LE +E+R Q++ E ++ +
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 958
Query: 553 LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 612
+ D L+ +LEE A + L+L + EA +E E + ++ N L+
Sbjct: 959 MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1007
Query: 613 AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 659
++ E+ D+ E E+K ++ +E + E V KK + E
Sbjct: 1008 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 660 MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
+K++ E + +QI+DL+ +IAEL+ Q A +E A R ++E Q K
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1114
Query: 720 HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
+ +K+R EL+ ++ Q + ER + E++ R L +ELE E
Sbjct: 1115 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1162
Query: 780 VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 839
+ TL+ ++EL K ++E+ ++ ++ E +Q++ Q Q V E E
Sbjct: 1163 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219
Query: 840 QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 899
++ K + + K E E +L E + +E ++K Q
Sbjct: 1220 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1268
Query: 900 REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 954
+E+ K + LN V + Q ++ + + N +E + L+ + L S +L
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1324
Query: 955 REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1014
++ +E+L + + S +L +LE E + + ++ ++ A +N+ + +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1373
Query: 1015 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074
ST +L K++Q S + L+ G + ++E+E +L QQ EE
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1423
Query: 1075 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1134
L++ + +E + ++ +Q + LE L A++ +
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1135 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
+ R K+ + ++ L + LE E +L T E + + + ELE S+
Sbjct: 1484 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 1194 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1244
T+ E+K Q+ +L+++L L + + + K Q DL ++K + L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 1245 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1297
+R +Y+ ED ++ L+ +L+ +E + D A++ +E ++ +LQ
Sbjct: 1602 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658
Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
++K + E S DE+ +E L+ + +LQE + + +A
Sbjct: 1659 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1714
Query: 1358 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1411
LE E+ E + L L++ R+ + + + EE ++E +E + + K
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 1412 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
++E+A T Q ++ ++ QN+ + + + G F ++TIA LE + +
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1832
Query: 1467 LQE-LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKL 1525
L+E + ++ +E KQ S +K+++LK ++ LQ+ + ++ E + ++EK
Sbjct: 1833 LEEQVEQEARE------KQAATKSLKQKDKKLKEIL--LQV--EDERKMAEQYKEQAEKG 1882
Query: 1526 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
L+ ++ EE +N ++ ++ ++ + + N A+ + V LK ++
Sbjct: 1883 NARVKQLKRQLEEAEEESQ-------RINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 139 bits (349), Expect = 4e-32
Identities = 242/1180 (20%), Positives = 492/1180 (41%), Gaps = 146/1180 (12%)
Query: 560 LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 619
LQ +E Q + L ++ E +E +H +EE N L ++AE +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 620 MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 679
E+ + + ELE+ + E +L+E +E+ Q+ + E + +Q+ DL+
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 963
Query: 680 NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 739
++ E + L+ A + ++ + ++ V ++++ L ++ +L L+ R++
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1017
Query: 740 AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
+ E EEK + LT +L+ H+ ++ L + L+KEE ++ LEK +
Sbjct: 1018 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1064
Query: 800 RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
R+L+ + +QI A+ + K E ++AL L+ Q+ L++ +
Sbjct: 1065 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123
Query: 860 EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 917
E + ++D ++ A + E KR+ L +E E L+ ++ L+S +
Sbjct: 1124 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1174
Query: 918 -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 976
R + Q++ L+ + + Q+ E++ H + + E E L Q ++ + +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 977 RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
LE E+ QE + KL A ++ C +R RAE++ ++ +LQ+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Query: 1024 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1068
+ IK + S S LQ +++ EE + + L+Q E+ E
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1352
Query: 1069 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
N L Q E K+N++ ++T +L +KL+ L+E F
Sbjct: 1353 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1184
T+ + ++ T+ + +L DD V DL + S++++++ K ++ A +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
S E R E+ + + + + + L + A E K++L +LK +++ L
Sbjct: 1469 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 1245 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1304
S K +DV + L++ R +ET+ +E +EL E+ +D ++E
Sbjct: 1524 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 1305 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1358
+ E+ +NEE + R + E +L++ QR E L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633
Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1418
++LE++ D I + EE + ++R + +++ ++E LE +A +
Sbjct: 1634 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1678
Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1477
T + ++++ + L+ Q+ + + +LEK +L +EL L R
Sbjct: 1679 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 1478 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
+ +++ L+A + L+ E Q +E + K Q+ L NE+
Sbjct: 1732 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
T + L +E+ K + E A K K I+ L+ K QL+
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1835
Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1652
+ + +++ + L++ +++L E+L Q E E + + + EK N LK +LE
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 1653 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDEL 1689
+ +S + ++ L+ EL E + +E + LK +L
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 110 bits (276), Expect = 1e-23
Identities = 221/1124 (19%), Positives = 459/1124 (40%), Gaps = 145/1124 (12%)
Query: 1020 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1076
RL +K+K + Q T +Q+ Q E + + + L L+Q L E ++L
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 1077 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1136
+A + E +M ++ +Q L+++ M + L+E +++
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 943
Query: 1137 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1196
R +Q++ ++ L+ +E + +Q ++V E +E + + + +
Sbjct: 944 RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003
Query: 1197 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
L + L+E++ L + EK ++L KLK + + +L
Sbjct: 1004 -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1050
Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
E+ SR+ L++ R +E + E +L A++ L+ +L K EE E +L +
Sbjct: 1051 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1106
Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
DE+ +N L + L+G I LQE + +R E +L E + +L T
Sbjct: 1107 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165
Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1435
L+ + K+E + L E+ ++HE + R ++
Sbjct: 1166 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1210
Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
+EE T L Q + A L+ K L++ L + +L + K + H K++
Sbjct: 1211 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1262
Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1547
+L+A + +LQ CS+ ++ L + KLQ E N I + S+S+
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 1548 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
T QEE QK V + +++ +L+ Q+ E Q L+ + L+ + S
Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 1608 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1654
+++KLQ+ Q+ E L Q+ +E +A ++ E+ K L++EL+
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1440
Query: 1655 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1707
V LVS+LE + + K + +++N K DE ++ + R + +
Sbjct: 1441 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
+ L E+L + + L E+ D ++ + + +++ +++ E Q +K+QL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1821
++++Q ED + + M +K DL+ ++ E ++++ LH+ + +
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 1822 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR- 1880
+ A L K L + E+ + ++ +LQ +++ + EL +R
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1673
Query: 1881 -------------EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQ 1920
+K + LE++L+ + + EK L E +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733
Query: 1921 FQKEQSPANRKVSQMNS-LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1979
Q E+ +++Q+ LE+E + ++ ++K + ++ E+ RSTA + S
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 1980 HAWDLQLLQQQACPMVPREQFLQ------LQRQLLQAERINQHLQEELENRTSETNTPQG 2033
Q L++Q + + ++ + + E L+E++E E
Sbjct: 1794 R----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE------KVNQLKEQV 2071
+ +Q ++E +++VE + K+ ++ ++ +V QLK Q+
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Score = 106 bits (264), Expect = 3e-22
Identities = 210/977 (21%), Positives = 408/977 (41%), Gaps = 126/977 (12%)
Query: 1169 VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQ 1228
V RQE +++ E ++ E + E + EL+ + SQL E+ +L ++
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELK--ELEQKHSQLTEEKNLL----------QE 901
Query: 1229 DLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKE 1288
L + + + +M R+ A+ K +L E++ E + EE E R + K+
Sbjct: 902 QLQAETELYAEAEEMRVRL--AAKKQEL--EEILHEMEARLEE---EEDRGQQLQAERKK 954
Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG-KIEKLQESVVQ 1347
+ ++ L+++L++ EE L LEK E KI+ E +LV+ Q K+ K ++ + +
Sbjct: 955 MAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 1348 RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL 1407
R + E E N+ +L E +I E + + E + Q L
Sbjct: 1014 RISDLTTNLAEEE---EKAKNLTKLKNKHES----------MISELEVRLKKEEKSRQEL 1060
Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-- 1465
EK+K L G E+ I E L K + QA +A L+ E
Sbjct: 1061 EKLKRK----LEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEIAQK 1113
Query: 1466 -----KLQELTRKLKERVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKV 1515
K++EL + + L ++ + EK+ EEL+A+ +L+ T +
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 1516 ELLRYESEKLQQENSILRNEIT--TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAA 1573
EL K +QE ++L+ + T + E + ++ + EE+ ++ E K+ A
Sbjct: 1174 EL----RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKAN 1228
Query: 1574 VQKMVENLKKQISEL--------------KIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
+ K + L+K+ ++L + K ++L+ + EL K S + ELN +
Sbjct: 1229 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE---VKIQTH 1676
+ ++ Q E E L E E + L +++ Q L+ E + V +
Sbjct: 1289 VHKL--QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 1677 IVQQENHLLKDELEKMKQLHRCPD---------LSDFQQKISSVLSYNEKLLKEKEALSE 1727
+++E + L+D+L++ + + + LSD ++K+ S E L + K+ +
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 1728 ELNSCVDKLAKSSLLEHRIATMKQE-QKSWEHQSASLKSQ--LVASQEKVQNLEDTVQNV 1784
E+ + + + + ++ K Q+ + L +Q LV++ EK Q D +
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1785 NLQMSRMKSDLRVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
+S +D R + E EA ++E +SL + L+ A E+ L + + L
Sbjct: 1467 EKNISSKYADER-DRAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDL 1523
Query: 1843 SWDKLD-----HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP-KHQK 1896
K D H + + ++ L + E ++T ++ + EL + + +LE N+ K Q
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 1897 HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK----VSQMNSLEQELETIHLENEGL 1952
+ E+++ L+R+ +++ E ++ + LE +L+ + L+ +
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 1953 KK------KQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQR 2005
K KQ+ KL Q+ + Q A S + +++A + +QLQ
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQE 1701
Query: 2006 QLLQAERIN-------QHLQEELENRTSETNTPQGNQEQL---VTVMEERMIEVEQKLKL 2055
L AER + L EEL + S N Q + +L + +EE + E + ++
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 2056 VKRLLQEKVNQLKEQVS 2072
+ ++ K Q EQ+S
Sbjct: 1762 MSDRVR-KATQQAEQLS 1777
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,428,771
Number of Sequences: 37866
Number of extensions: 3608181
Number of successful extensions: 49992
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 496
Number of HSP's successfully gapped in prelim test: 1534
Number of HSP's that attempted gapping in prelim test: 16160
Number of HSP's gapped (non-prelim): 14520
length of query: 2096
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1978
effective length of database: 13,779,330
effective search space: 27255514740
effective search space used: 27255514740
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.