Guide to the Human Genome
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Search of human proteins with 33946313

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33946313 ninein isoform 4 [Homo sapiens]
         (2096 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33946313 ninein isoform 4 [Homo sapiens]                          4100   0.0  
gi|33946321 ninein isoform 5 [Homo sapiens]                          4020   0.0  
gi|148536869 ninein isoform 2 [Homo sapiens]                         3964   0.0  
gi|148536871 ninein isoform 1 [Homo sapiens]                         3894   0.0  
gi|55749678 ninein-like [Homo sapiens]                                424   e-118
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    225   3e-58
gi|21735548 centrosomal protein 2 [Homo sapiens]                      212   3e-54
gi|148746195 trichohyalin [Homo sapiens]                              208   4e-53
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   206   2e-52
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   204   1e-51
gi|71061468 centromere protein E [Homo sapiens]                       200   1e-50
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       176   2e-43
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       176   2e-43
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        176   2e-43
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        176   2e-43
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        176   2e-43
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        176   2e-43
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        176   2e-43
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        176   2e-43
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    170   1e-41
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            169   3e-41
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   167   1e-40
gi|55770834 centromere protein F [Homo sapiens]                       163   2e-39
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        160   2e-38
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    157   1e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   157   1e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   157   1e-37
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]        155   3e-37
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                153   1e-36
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   153   1e-36

>gi|33946313 ninein isoform 4 [Homo sapiens]
          Length = 2096

 Score = 4100 bits (10633), Expect = 0.0
 Identities = 2096/2096 (100%), Positives = 2096/2096 (100%)

Query: 1    MAEVTVPRVYVVFGIHCIMAKASSDVQVSGFHRKIQHVKNELCHMLSLEEVAPVLQQTLL 60
            MAEVTVPRVYVVFGIHCIMAKASSDVQVSGFHRKIQHVKNELCHMLSLEEVAPVLQQTLL
Sbjct: 1    MAEVTVPRVYVVFGIHCIMAKASSDVQVSGFHRKIQHVKNELCHMLSLEEVAPVLQQTLL 60

Query: 61   QDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQ 120
            QDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQ
Sbjct: 61   QDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQ 120

Query: 121  ESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQS 180
            ESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQS
Sbjct: 121  ESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQS 180

Query: 181  GSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPD 240
            GSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPD
Sbjct: 181  GSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPD 240

Query: 241  GTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRV 300
            GTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRV
Sbjct: 241  GTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRV 300

Query: 301  FSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTK 360
            FSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTK
Sbjct: 301  FSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTK 360

Query: 361  NSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERR 420
            NSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERR
Sbjct: 361  NSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERR 420

Query: 421  NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA
Sbjct: 421  NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
            LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT
Sbjct: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540

Query: 541  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 600
            QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG
Sbjct: 541  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 600

Query: 601  SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 660
            SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM
Sbjct: 601  SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 660

Query: 661  KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
            KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH
Sbjct: 661  KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720

Query: 721  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
            LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV
Sbjct: 721  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780

Query: 781  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
            EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ
Sbjct: 781  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840

Query: 841  SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
            SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER
Sbjct: 841  SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900

Query: 901  EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV 960
            EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV
Sbjct: 901  EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV 960

Query: 961  LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR 1020
            LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR
Sbjct: 961  LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR 1020

Query: 1021 LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1080
            LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH
Sbjct: 1021 LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAH 1080

Query: 1081 EQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQ 1140
            EQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQ
Sbjct: 1081 EQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQ 1140

Query: 1141 VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
            VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW
Sbjct: 1141 VEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED
Sbjct: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEV 1320
            VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEV
Sbjct: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEV 1320

Query: 1321 KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV 1380
            KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV
Sbjct: 1321 KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV 1380

Query: 1381 PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEEN 1440
            PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEEN
Sbjct: 1381 PRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEEN 1440

Query: 1441 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500
            TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM
Sbjct: 1441 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500

Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEM 1560
            MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEM
Sbjct: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEM 1560

Query: 1561 WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL 1620
            WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL
Sbjct: 1561 WQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL 1620

Query: 1621 TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1680
            TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ
Sbjct: 1621 TEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1680

Query: 1681 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
            ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS
Sbjct: 1681 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740

Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800
            LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ
Sbjct: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800

Query: 1801 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ 1860
            EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ
Sbjct: 1801 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ 1860

Query: 1861 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920
            ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ
Sbjct: 1861 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920

Query: 1921 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPH 1980
            FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPH
Sbjct: 1921 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPH 1980

Query: 1981 AWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT 2040
            AWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT
Sbjct: 1981 AWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT 2040

Query: 2041 VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH 2096
            VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH
Sbjct: 2041 VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH 2096


>gi|33946321 ninein isoform 5 [Homo sapiens]
          Length = 2090

 Score = 4020 bits (10425), Expect = 0.0
 Identities = 2056/2061 (99%), Positives = 2057/2061 (99%)

Query: 36   QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95
            Q    +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 30   QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89

Query: 96   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155
            CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 90   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149

Query: 156  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215
            QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 150  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209

Query: 216  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275
            ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 210  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269

Query: 276  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335
            MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 270  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329

Query: 336  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395
            DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 330  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389

Query: 396  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
            LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 390  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449

Query: 456  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
            KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509

Query: 516  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575
            NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 510  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569

Query: 576  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635
            LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 570  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629

Query: 636  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695
            EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 630  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689

Query: 696  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755
            HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 690  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 756  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815
            WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 750  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
            RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869

Query: 876  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935
            AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 870  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929

Query: 936  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
            QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 930  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989

Query: 996  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
            MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 990  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049

Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
            LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109

Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
            EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169

Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
            IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229

Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
            VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289

Query: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
            LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349

Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
            ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409

Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
            AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469

Query: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535
            ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529

Query: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
            ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589

Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
            DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649

Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
            QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709

Query: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775
            EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769

Query: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835
            NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829

Query: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895
            HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889

Query: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
            KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949

Query: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015
            QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009

Query: 2016 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPG 2075
            HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPG
Sbjct: 2010 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPG 2069

Query: 2076 HLCSPTSHSSFNSSFTSLYCH 2096
            HLCSPTSHSSFNSSFTSLYCH
Sbjct: 2070 HLCSPTSHSSFNSSFTSLYCH 2090


>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score = 3964 bits (10281), Expect = 0.0
 Identities = 2030/2036 (99%), Positives = 2032/2036 (99%)

Query: 36   QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95
            Q    +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 30   QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89

Query: 96   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155
            CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 90   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149

Query: 156  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215
            QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 150  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209

Query: 216  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275
            ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 210  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269

Query: 276  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335
            MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 270  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329

Query: 336  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395
            DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 330  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389

Query: 396  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
            LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 390  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449

Query: 456  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
            KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509

Query: 516  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575
            NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 510  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569

Query: 576  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635
            LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 570  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629

Query: 636  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695
            EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 630  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689

Query: 696  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755
            HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 690  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 756  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815
            WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 750  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
            RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869

Query: 876  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935
            AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 870  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929

Query: 936  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
            QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 930  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989

Query: 996  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
            MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 990  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049

Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
            LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109

Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
            EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169

Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
            IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229

Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
            VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289

Query: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
            LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349

Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
            ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409

Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
            AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469

Query: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535
            ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529

Query: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
            ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589

Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
            DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649

Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
            QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709

Query: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775
            EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769

Query: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835
            NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829

Query: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895
            HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889

Query: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
            KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949

Query: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015
            QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009

Query: 2016 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
            HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ+
Sbjct: 2010 HLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 274/1466 (18%), Positives = 568/1466 (38%), Gaps = 217/1466 (14%)

Query: 704  EEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 763
            +EE +   +   +   H + +   ++E E + R          +        W EEK++ 
Sbjct: 130  DEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQE 189

Query: 764  LTQELE-----QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 818
            + ++L        ++++L S+ E++ L+  +   E+LE+    L              T 
Sbjct: 190  VCEDLGITRDGHLNRKKLVSICEQYGLQNVD--GEMLEEVFHNLDPDG----------TM 237

Query: 819  QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECA-E 877
             +E  F      + +  +S   S    YRQ  + L  Q  +E  +       +T      
Sbjct: 238  SVEDFFYG----LFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFR 293

Query: 878  AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ----DLEDLRNVSE 933
                L + +       ++ T + E +E +            Q++L+     L+   N++E
Sbjct: 294  VFSCLDDGMGHASVERILDTWQEEGIENS------------QEILKALDFSLDGNINLTE 341

Query: 934  TQQSLLSDQILELKSSHKRELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 992
               +L ++ ++   S H+  L   + E+       +Q+     E+ ++  D ++ E +  
Sbjct: 342  LTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR---EKEKLRSDLDKAEKLKS 398

Query: 993  LLAME-NIHKATCETADRERA-----EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIG 1046
            L+A E + H A  E  +         E    I+ L++++++ ++            Q  G
Sbjct: 399  LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI---------LQQAG 449

Query: 1047 EEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP 1106
            ++ +E +  +   +  E  + +   + L      E  + EN +   E   L  +LQ+   
Sbjct: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN-- 507

Query: 1107 GLVMSSCLDEPATEFFGNT-AEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDLGS 1163
                   L+    E FG+      E FLQ+ R  Q+     R   VL D  D+   +L  
Sbjct: 508  -------LENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560

Query: 1164 -TGTSSVQRQEVKIEESEA------------------------SVEGFSELENSEETRTE 1198
                  V R  +K   SE                         S+E    +E  +E    
Sbjct: 561  YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620

Query: 1199 S-----WELKNQISQLQEQLMMLCADCDRASEK-KQDLLFDVSVLKKKLKMLERIPEASP 1252
                   EL++++   ++QL      C +A E  KQ    +   L+K++  L+       
Sbjct: 621  DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ 680

Query: 1253 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1312
                + ++   E  C  EE +    +    LE  K    E  RLQ E++    +T+   S
Sbjct: 681  GQAAVLKEAHHEATCRHEEEKK---QLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 737

Query: 1313 LEKSYDEVKIE---NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI 1369
             E+  + ++      E++  L   L+   ++   S+V++      E   E LE +    +
Sbjct: 738  FEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE-KHQREL 796

Query: 1370 LQLNQTLE-ECVPRVRSVHHVIE-ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE 1427
             +  + +E EC  R   +    + +C++  +  E   Q LE     E+  L       QE
Sbjct: 797  QEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDL-------QE 849

Query: 1428 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDV 1487
            + R       EE +     +D+  Q  A   EL      L+E  ++ K    +L +++++
Sbjct: 850  QQR-------EEKSQWEFEKDELTQECAEAQEL------LKETLKREKTTSLVLTQEREM 896

Query: 1488 LSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISN 1547
            L     E+  K  ++ + +   ++ Q +E LR  SE  Q   S    E+ + ++ +    
Sbjct: 897  L-----EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 951

Query: 1548 LKLGTLNGSQEEMW-QKTETVKQENAAV-QKMVENLKKQISELKIKNQQLDLENTELSQK 1605
             ++    G+ E++  Q+ E ++ E+    Q+M+  L    +  K   +  D E  E+S +
Sbjct: 952  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1011

Query: 1606 NSQNQEKLQELNQRLTEML-----CQ---KEKEPGNSALEEREQEKFNLKEELERCKVQS 1657
             S+ Q K++E+ Q  + +      CQ   +E+  G+ AL   +Q +  L+E  +   V  
Sbjct: 1012 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGD---VLL 1068

Query: 1658 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEK 1717
            S   +  +A    VK+ T I + +  L K  LE    +  C D     +   +     E 
Sbjct: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQK--LEPGLVMSSCLD-EPATEFFGNTAEQTEP 1125

Query: 1718 LLKEKEALSEELNSCVDKLAKSSLLEHRI--------ATMKQEQKSWEHQSASLK--SQL 1767
             L++    ++++     +   S L +  +        +++++++   E   AS++  S+L
Sbjct: 1126 FLQQNR--TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1183

Query: 1768 VASQE---KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824
              S+E   +   L++ +  +  Q+  + +D     ++K+ L  +V  L K+L+       
Sbjct: 1184 ENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML---ER 1240

Query: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVR 1884
             PE +     L+    R +    D L  E + +  + +E L+   + T AE+   +++++
Sbjct: 1241 IPEASPKYKLLYEDVSREN----DCLQEELRMMETRYDEALENNKELT-AEVFRLQDELK 1295

Query: 1885 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1944
            ++E                     +  LSL++  D+ + E    N  V ++    ++L+ 
Sbjct: 1296 KMEE------------------VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQE 1337

Query: 1945 IHLEN-------EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
              ++          L+  +++ D  ++++        P        ++  +Q+       
Sbjct: 1338 SVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE------- 1390

Query: 1998 EQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK----- 2052
             Q+L+   QLL  E++  H    L             Q Q++      ++  + K     
Sbjct: 1391 NQYLEGNTQLL--EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448

Query: 2053 -----LKLVKRLLQEKVNQLKEQVSL 2073
                 L+L K  LQE   +LKE+V++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTI 1474


>gi|148536871 ninein isoform 1 [Homo sapiens]
          Length = 2046

 Score = 3894 bits (10099), Expect = 0.0
 Identities = 1992/1997 (99%), Positives = 1993/1997 (99%)

Query: 36   QHVKNELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 95
            Q    +LCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD
Sbjct: 30   QEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPD 89

Query: 96   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 155
            CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT
Sbjct: 90   CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKT 149

Query: 156  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 215
            QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS
Sbjct: 150  QRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVS 209

Query: 216  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 275
            ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS
Sbjct: 210  ICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLS 269

Query: 276  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 335
            MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL
Sbjct: 270  MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKAL 329

Query: 336  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 395
            DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD
Sbjct: 330  DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD 389

Query: 396  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
            LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG
Sbjct: 390  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 449

Query: 456  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
            KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE
Sbjct: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 509

Query: 516  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 575
            NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR
Sbjct: 510  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLR 569

Query: 576  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 635
            LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL
Sbjct: 570  LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL 629

Query: 636  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 695
            EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA
Sbjct: 630  EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEA 689

Query: 696  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 755
            HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA
Sbjct: 690  HHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSA 749

Query: 756  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 815
            WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR
Sbjct: 750  WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNR 809

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
            RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC
Sbjct: 810  RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869

Query: 876  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935
            AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ
Sbjct: 870  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929

Query: 936  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
            QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA
Sbjct: 930  QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989

Query: 996  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
            MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA
Sbjct: 990  MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049

Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
            LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD
Sbjct: 1050 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1109

Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
            EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK
Sbjct: 1110 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1169

Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
            IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS
Sbjct: 1170 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1229

Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
            VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR
Sbjct: 1230 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1289

Query: 1296 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
            LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE
Sbjct: 1290 LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1349

Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
            ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI
Sbjct: 1350 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1409

Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
            AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1469

Query: 1476 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1535
            ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE
Sbjct: 1470 ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNE 1529

Query: 1536 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
            ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL
Sbjct: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589

Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
            DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1649

Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
            QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1709

Query: 1716 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775
            EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ
Sbjct: 1710 EKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769

Query: 1776 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1835
            NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL
Sbjct: 1770 NLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGL 1829

Query: 1836 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1895
            HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ
Sbjct: 1830 HNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQ 1889

Query: 1896 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
            KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK
Sbjct: 1890 KHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949

Query: 1956 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2015
            QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQ 2009

Query: 2016 HLQEELENRTSETNTPQ 2032
            HLQEELENRTSETNTPQ
Sbjct: 2010 HLQEELENRTSETNTPQ 2026



 Score =  139 bits (350), Expect = 3e-32
 Identities = 342/1663 (20%), Positives = 669/1663 (40%), Gaps = 323/1663 (19%)

Query: 448  EQILQQAGKQRLELEQEIEKA---KTEENYIRDRLALSLKENSRLENELLENAEKLAEYE 504
            E+IL    ++ +E  QEI KA     + N     L L+L EN  L  +   +   LA ++
Sbjct: 308  ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL-ENELLVTKNSIHQAALASFK 366

Query: 505  NLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL 564
                 L   ++ V+ EK               E+L    ++ E+   ++  +VD+  + +
Sbjct: 367  AEIRHLLERVDQVVREK---------------EKLRSDLDKAEKLKSLMASEVDDHHAAI 411

Query: 565  EEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQH 624
            E  R     LR  L     E + A    +  E     ++     + +E E+   + +E +
Sbjct: 412  E--RRNEYNLR-KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENY 468

Query: 625  HRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 684
             RD   L L+   ++ +      E + + +K  E     +EN T+ L++   +L+N +AE
Sbjct: 469  IRDRLALSLKENSRLEN------ELLENAEKLAE-----YENLTNKLQR---NLENVLAE 514

Query: 685  LQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 744
              G                  +    +  L+EE                  RLTQ +  +
Sbjct: 515  KFGDL----------------DPSSAEFFLQEE------------------RLTQMRNEY 540

Query: 745  EREREGLQSSAWTEEKVRGLTQELEQFH-QEQLTSLVEKHTLEKEELRKELLEKHQRELQ 803
            ER+   LQ      ++V  L  ELE++  Q ++  L  K++  +E      +E +   ++
Sbjct: 541  ERQCRVLQ------DQVDELQSELEEYRAQGRVLRLPLKNSPSEE------VEANSGGIE 588

Query: 804  EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ 863
                    ECN     IEA             E  ++ ++ ++ +++  L+ +  ++   
Sbjct: 589  PEHGLGSEECNPLNMSIEA-------------ELVIEQMKEQHHRDICCLRLELEDKVRH 635

Query: 864  WEFEKDELTQECAEAQELLKE-------TLKRE----KTTSLVLTQEREMLEKTYKEHLN 912
            +E + DE    C +AQE +K+       TL+++    K     L  +  +L++ + E   
Sbjct: 636  YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695

Query: 913  SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-SEQLA 971
                E++QL   LE+ +   + +  L  +  L+ + +  +   ERE    Q+ A +E+  
Sbjct: 696  RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755

Query: 972  SQRLERLEMEHDQERQEMMSK-LLAMENIHKATCETADRE----RAEMSTEISRLQSKIK 1026
                + LE  H ++   ++ K  L  E + K   E   RE    R +M TE +R  S+I+
Sbjct: 756  RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIE 815

Query: 1027 EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1086
                     +  QS CQ + E     + AL  L+         G     L+   EQ  +E
Sbjct: 816  ---------AQFQSDCQKVTER---CESALQSLE---------GRYRQELKDLQEQQREE 854

Query: 1087 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR 1146
              +   E   L Q   + +  L  +   ++  +       E  E   +++    V  V R
Sbjct: 855  KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMV--VER 912

Query: 1147 RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1206
            + +L DLED  +R++  T  S +  Q ++++ S        EL   EE   ++   +   
Sbjct: 913  QQLLQDLED--LRNVSETQQSLLSDQILELKSSHKR-----ELREREEVLCQAGASEQLA 965

Query: 1207 SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND 1266
            SQ  E+L M         +++Q+++        KL  +E I      +K   E   RE  
Sbjct: 966  SQRLERLEM------EHDQERQEMM-------SKLLAMENI------HKATCETADRER- 1005

Query: 1267 CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1326
                                 E++ E+ RLQ ++K+M++ T     L+     +  E  E
Sbjct: 1006 --------------------AEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045

Query: 1327 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV 1386
             +       G +  LQ+               E L  E    +L L +  E+ V     +
Sbjct: 1046 GD-------GALSLLQQG--------------EQLLEENGDVLLSLQRAHEQAVKENVKM 1084

Query: 1387 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1446
               I   +Q  Q LE    +   +      +   T +        Q +  L++N T    
Sbjct: 1085 ATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE--------QTEPFLQQNRTK--- 1133

Query: 1447 QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI 1506
            Q +    +  +++LE ++       R L    T  V++++V     K EE +A +     
Sbjct: 1134 QVEGVTRRHVLSDLEDDEV------RDLGSTGTSSVQRQEV-----KIEESEASVEGF-- 1180

Query: 1507 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1566
              SE++         SE+ + E+  L+N+I+ L E+  +        +  ++++      
Sbjct: 1181 --SELEN--------SEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1230

Query: 1567 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1626
            +K++     KM+E + +   + K+  + +  EN  L       QE+L+ +  R  E L  
Sbjct: 1231 LKKK----LKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETRYDEALEN 1279

Query: 1627 KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK 1686
             +         E   E F L++EL++ +  + T +S LE    EVKI+   +      L+
Sbjct: 1280 NK---------ELTAEVFRLQDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVLRLQ 1329

Query: 1687 DELEKMKQ--LHRCPDLSDFQQKISSV-LSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1743
             ++EK+++  + RC D   ++  + ++ +  +  +L+    L++ L  CV ++     + 
Sbjct: 1330 GKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQ----LNQTLEECVPRVRS---VH 1381

Query: 1744 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE 1803
            H I   KQE +  E  +  L+        ++  L  T+Q             R   Q + 
Sbjct: 1382 HVIEECKQENQYLEGNTQLLEK---VKAHEIAWLHGTIQT---------HQERPRVQNQV 1429

Query: 1804 ALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENE 1863
             L++    L  Q ++   ++   E+    + L    ++L  +++  L+ ++  L   E E
Sbjct: 1430 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK-ERVTILVKQKDVLSHGEKE 1488

Query: 1864 R-LQTMVQNTKAELTHSREKVRQL--ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920
              L+ M+ + +   +  ++KV  L  ES  L                +QE   L+ E   
Sbjct: 1489 EELKAMMHDLQITCSEMQQKVELLRYESEKL----------------QQENSILRNEITT 1532

Query: 1921 FQKEQSPANRKVSQMNSLEQEL----ETIHLENEGLKKKQVKLDEQLMEMQ------HLR 1970
              +E S +N K+  +N  ++E+    ET+  EN  ++K    L +Q+ E++       L 
Sbjct: 1533 LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592

Query: 1971 STA-TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2029
            +T  +   S +   LQ L Q+   M+ +++       L + E+   +L+EELE    +++
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1652

Query: 2030 TPQGNQEQLVTVMEERMIEVEQKLKLVKR---LLQEKVNQLKE 2069
            T       LV+ +E  + EV+ +  +V++   LL++++ ++K+
Sbjct: 1653 T-------LVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 274/1466 (18%), Positives = 568/1466 (38%), Gaps = 217/1466 (14%)

Query: 704  EEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 763
            +EE +   +   +   H + +   ++E E + R          +        W EEK++ 
Sbjct: 130  DEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQE 189

Query: 764  LTQELE-----QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 818
            + ++L        ++++L S+ E++ L+  +   E+LE+    L              T 
Sbjct: 190  VCEDLGITRDGHLNRKKLVSICEQYGLQNVD--GEMLEEVFHNLDPDG----------TM 237

Query: 819  QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECA-E 877
             +E  F      + +  +S   S    YRQ  + L  Q  +E  +       +T      
Sbjct: 238  SVEDFFYG----LFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFR 293

Query: 878  AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ----DLEDLRNVSE 933
                L + +       ++ T + E +E +            Q++L+     L+   N++E
Sbjct: 294  VFSCLDDGMGHASVERILDTWQEEGIENS------------QEILKALDFSLDGNINLTE 341

Query: 934  TQQSLLSDQILELKSSHKRELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 992
               +L ++ ++   S H+  L   + E+       +Q+     E+ ++  D ++ E +  
Sbjct: 342  LTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR---EKEKLRSDLDKAEKLKS 398

Query: 993  LLAME-NIHKATCETADRERA-----EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIG 1046
            L+A E + H A  E  +         E    I+ L++++++ ++            Q  G
Sbjct: 399  LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI---------LQQAG 449

Query: 1047 EEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP 1106
            ++ +E +  +   +  E  + +   + L      E  + EN +   E   L  +LQ+   
Sbjct: 450  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRN-- 507

Query: 1107 GLVMSSCLDEPATEFFGNT-AEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDLGS 1163
                   L+    E FG+      E FLQ+ R  Q+     R   VL D  D+   +L  
Sbjct: 508  -------LENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560

Query: 1164 -TGTSSVQRQEVKIEESEA------------------------SVEGFSELENSEETRTE 1198
                  V R  +K   SE                         S+E    +E  +E    
Sbjct: 561  YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620

Query: 1199 S-----WELKNQISQLQEQLMMLCADCDRASEK-KQDLLFDVSVLKKKLKMLERIPEASP 1252
                   EL++++   ++QL      C +A E  KQ    +   L+K++  L+       
Sbjct: 621  DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ 680

Query: 1253 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1312
                + ++   E  C  EE +    +    LE  K    E  RLQ E++    +T+   S
Sbjct: 681  GQAAVLKEAHHEATCRHEEEKK---QLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 737

Query: 1313 LEKSYDEVKIE---NEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI 1369
             E+  + ++      E++  L   L+   ++   S+V++      E   E LE +    +
Sbjct: 738  FEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE-KHQREL 796

Query: 1370 LQLNQTLE-ECVPRVRSVHHVIE-ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE 1427
             +  + +E EC  R   +    + +C++  +  E   Q LE     E+  L       QE
Sbjct: 797  QEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDL-------QE 849

Query: 1428 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDV 1487
            + R       EE +     +D+  Q  A   EL      L+E  ++ K    +L +++++
Sbjct: 850  QQR-------EEKSQWEFEKDELTQECAEAQEL------LKETLKREKTTSLVLTQEREM 896

Query: 1488 LSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISN 1547
            L     E+  K  ++ + +   ++ Q +E LR  SE  Q   S    E+ + ++ +    
Sbjct: 897  L-----EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 951

Query: 1548 LKLGTLNGSQEEMW-QKTETVKQENAAV-QKMVENLKKQISELKIKNQQLDLENTELSQK 1605
             ++    G+ E++  Q+ E ++ E+    Q+M+  L    +  K   +  D E  E+S +
Sbjct: 952  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1011

Query: 1606 NSQNQEKLQELNQRLTEML-----CQ---KEKEPGNSALEEREQEKFNLKEELERCKVQS 1657
             S+ Q K++E+ Q  + +      CQ   +E+  G+ AL   +Q +  L+E  +   V  
Sbjct: 1012 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGD---VLL 1068

Query: 1658 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEK 1717
            S   +  +A    VK+ T I + +  L K  LE    +  C D     +   +     E 
Sbjct: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQK--LEPGLVMSSCLD-EPATEFFGNTAEQTEP 1125

Query: 1718 LLKEKEALSEELNSCVDKLAKSSLLEHRI--------ATMKQEQKSWEHQSASLK--SQL 1767
             L++    ++++     +   S L +  +        +++++++   E   AS++  S+L
Sbjct: 1126 FLQQNR--TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1183

Query: 1768 VASQE---KVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824
              S+E   +   L++ +  +  Q+  + +D     ++K+ L  +V  L K+L+       
Sbjct: 1184 ENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML---ER 1240

Query: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVR 1884
             PE +     L+    R +    D L  E + +  + +E L+   + T AE+   +++++
Sbjct: 1241 IPEASPKYKLLYEDVSREN----DCLQEELRMMETRYDEALENNKELT-AEVFRLQDELK 1295

Query: 1885 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1944
            ++E                     +  LSL++  D+ + E    N  V ++    ++L+ 
Sbjct: 1296 KMEE------------------VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQE 1337

Query: 1945 IHLEN-------EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
              ++          L+  +++ D  ++++        P        ++  +Q+       
Sbjct: 1338 SVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE------- 1390

Query: 1998 EQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK----- 2052
             Q+L+   QLL  E++  H    L             Q Q++      ++  + K     
Sbjct: 1391 NQYLEGNTQLL--EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448

Query: 2053 -----LKLVKRLLQEKVNQLKEQVSL 2073
                 L+L K  LQE   +LKE+V++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTI 1474


>gi|55749678 ninein-like [Homo sapiens]
          Length = 1382

 Score =  424 bits (1090), Expect = e-118
 Identities = 289/794 (36%), Positives = 444/794 (55%), Gaps = 54/794 (6%)

Query: 41  ELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILS-----RTLSNEEHFQEPD 95
           +LC  L LE+  PVL QTLL ++   RV+F++FKE  + +LS     R    +    E  
Sbjct: 34  QLCLKLHLEQQLPVLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESA 93

Query: 96  CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHI----------- 144
            S    PKYV G K YGRRS PE  ++  E   V   E   + +  SH+           
Sbjct: 94  ASSAIPPKYVNGSKWYGRRSRPELCDAATEARRVP--EQQTQASLKSHLWRSASLESVES 151

Query: 145 -PAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGIT 203
             + + +E  K  ++E +EA+GQL+ W+ +D  + Q   SP  D  E +++ V E+LG+ 
Sbjct: 152 PKSDEEAESTKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVG 211

Query: 204 RDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTP 261
             GHL+ ++L  +C+  GLQ ++ E LE++F+ LD DG   +S+E+F  GLF +  +L  
Sbjct: 212 SSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLL 271

Query: 262 SASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIG-FRVFSCLDDGMGHASVERILDTW 320
            +ST  +  K     Q  +ESG  TTT+S++ S     R+FS +DDG G A  +++L  W
Sbjct: 272 ESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMW 331

Query: 321 QEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLE 380
            +EGI+N +EIL++LDFS+D  +NL ELT AL+NEL+   +++ QAALA +  E+ +   
Sbjct: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391

Query: 381 RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALK 440
           +V+Q+ RE++K R DL++AEK       E+DD H+ +E+  E  ++ L++ Y+ER++ L+
Sbjct: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451

Query: 441 NELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 500
           +E+  ERE   +QA +QR  LE ++ + + EE  +R++L L+LKENSRL+ E++E  EKL
Sbjct: 452 SEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKL 511

Query: 501 AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
           ++ E L  KLQ++LE VL +K   L+P SAE   QEER   +  EYE +CR LQD+ DEL
Sbjct: 512 SDSERLALKLQKDLEFVLKDK---LEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDEL 568

Query: 561 QSELEEYRAQGRVLRLPL-KNSPSEEVEANSGGIEPEHGLG----SEECNPLNMSIEAEL 615
           Q+ELE     G   RLP  ++SPS   +     +    GLG    S   N   +SIE EL
Sbjct: 569 QAELE-----GLWARLPKNRHSPSWSPDGRRRQLP---GLGPAGISFLGNSAPVSIETEL 620

Query: 616 VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQI 675
           ++EQ+KE H++D   LR +LE KV +YE+++     + +K +++M+Q    E   LE Q 
Sbjct: 621 MMEQVKE-HYQD---LRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQK 676

Query: 676 SDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKA 735
           +DL+ E+ E   +     +   + T R  E +   Q+ L    T     L L+H   L+ 
Sbjct: 677 ADLE-ELHEKSQEVIWGLQEQLQDTARGPEPE---QMGLAPCCTQALCGLALRHHSHLQQ 732

Query: 736 RLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELL 795
              +A+A    E  GL +        R LT ELE+  Q  L     + +   E+L  E  
Sbjct: 733 IRREAEAELSGELSGLGAL----PARRDLTLELEEPPQGPL----PRGSQRSEQLELERA 784

Query: 796 EKHQRELQEGREKM 809
            K Q    E R +M
Sbjct: 785 LKLQPCASEKRAQM 798



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)

Query: 537  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
            ER  +   E+ ++       +++L  +  ++  QG   RL L  S   EVEA       E
Sbjct: 408  ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457

Query: 597  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
              L  E+ +    ++E ++   Q +E   R+   L L+   ++   +K++ E V     +
Sbjct: 458  RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514

Query: 657  QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
            +    +  ++    L+ ++     E+ A+ +  AAVLKE  +E  CR  +++        
Sbjct: 515  ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566

Query: 716  EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 775
                            EL+A L    A   + R    S +W+ +   G  ++L       
Sbjct: 567  ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604

Query: 776  LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 834
            ++ L     +  E EL  E +++H ++L   R ++ET+ N    +I A            
Sbjct: 605  ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649

Query: 835  CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 894
                   L+  + +E KD+++ +R E S  E +K +L +   ++QE++    ++ + T+ 
Sbjct: 650  -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702

Query: 895  VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 952
                E+  L     + L  + +     LQ +   R  +E + S  L     L  +     
Sbjct: 703  GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759

Query: 953  ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1009
            EL E  +     G+  SEQL  +R  +L+    ++R +M +S  L  E +  A  +  D 
Sbjct: 760  ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819

Query: 1010 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1064
               E   +       +    Q+ T  L  L+ GC   GE  +     GDG  S    G  
Sbjct: 820  PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876

Query: 1065 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1117
                      + Q         +   +   SR+Q          ++ EP    ++ L++P
Sbjct: 877  PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936

Query: 1118 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1171
                         A QT+P + +   +       +   L  ++++  R            
Sbjct: 937  GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996

Query: 1172 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1226
            Q+ +   +E ++E      + E  R  S     Q++  Q       A  +    K     
Sbjct: 997  QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053

Query: 1227 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1278
             K D+   +  L+  ++ LE+  +     +L +  +S EN  L       ++EL   E+ 
Sbjct: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113

Query: 1279 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1327
            +D      E L+ +KE      EV   Q++  K  + ++    L L +     + +NEE 
Sbjct: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173

Query: 1328 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1383
             V +  L   +E++  S  Q+ D        LE L  E     L   +L QTLEE   +V
Sbjct: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233

Query: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1443
            +  H  + + + +      + Q +  V    +A LH  +    E+ R +     EE+   
Sbjct: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287

Query: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503
            L   ++  +    I  L+  +  LQE   KLKE+              EK  +   ++ +
Sbjct: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332

Query: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1541
            L +  + + + ++    +    ++++ +L  ++  LN+
Sbjct: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 83/356 (23%), Positives = 152/356 (42%), Gaps = 68/356 (19%)

Query: 1733 VDKLAKSSLLEHRIATMKQEQKSWEHQSAS---------LKSQLVASQEKVQNLEDTVQN 1783
            V+   + SL  H    +   Q SW+ Q A+         L+ +    + K+ +LED V+ 
Sbjct: 1014 VEVARRGSLPSH--LQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA 1071

Query: 1784 VNLQMSRMKSD---LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1840
            +   +   ++D        +E   LK ++  + ++L+ A         +TH +    Q+K
Sbjct: 1072 LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE--------STHDA----QRK 1119

Query: 1841 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1900
             +       ++ ++++    E E L    QN K +L+    +V QL       HQ     
Sbjct: 1120 EIE------VLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA-STHQAQ--- 1169

Query: 1901 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1960
                   E+ +++++      ++      ++  Q+  L  ELE ++ E++ L+    +L 
Sbjct: 1170 ------NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223

Query: 1961 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQA-----CPMVPREQFLQLQRQL-LQAERIN 2014
            + L E Q     A          L+L Q QA       +VP+++  +L R L LQ E+  
Sbjct: 1224 QTLEESQDQVQGA---------HLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQAR 1274

Query: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
            + L  + E             E+ +   EER+ E E  LK ++ LLQEKV++LKEQ
Sbjct: 1275 RRLDAQREEH-----------EKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQ 1319



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)

Query: 387  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 446
            REK+ + + L   E +   +   VD     +   +     +L EE       LKN+L + 
Sbjct: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103

Query: 447  REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 506
            R++ L+ A        +EIE  K ++      + +  ++N   +++L +   ++ +    
Sbjct: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158

Query: 507  TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 566
                       L ++       + E  +  + LTQ   E  R  +   DQ+ +L+ ELE 
Sbjct: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207

Query: 567  YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 626
               + + L+LP  +  ++ +E +   ++  H                 L + Q + QH +
Sbjct: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249

Query: 627  DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 682
            ++   RL  +D+V    + L       ++  +  ++ HE +    E+++ +    LKN  
Sbjct: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306

Query: 683  AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 741
              LQ +   LKE   + T      K  L +K L  E  HL   L               Q
Sbjct: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345

Query: 742  ASFEREREGLQSSAWTEEKVRGLTQ 766
            A+ E++R   + S   EEKVR L +
Sbjct: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)

Query: 699  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 752
            A+CR + E+ Q    ++EE+     +   +   E +AR   A      + S E  R G  
Sbjct: 966  ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022

Query: 753  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
             S       +G  QE       QL +  E  T    E  K+ +E     L++    +E  
Sbjct: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075

Query: 813  CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 872
             + R +      + +  +++E   + L++  GR RQEL+  +     ++ + E  K +  
Sbjct: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129

Query: 873  QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 926
            + C+E + L       K+ L +     L L QE    +   +EH     V  Q L Q LE
Sbjct: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185

Query: 927  DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 976
            ++    + Q    SDQI +L+           S +    E  + L ++    Q A  RL 
Sbjct: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241

Query: 977  RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1029
            + + +H        Q+R   + +LL+++   +      D +R E   ++   + +++E +
Sbjct: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299

Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1086
                 + ML        +E+ E +    LL   ++L  EN  ++ +LQ   E+   A K+
Sbjct: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357

Query: 1087 NVKMATEISRLQQRLQKLEP 1106
            +  +  ++  L + + ++ P
Sbjct: 1358 SRLLEEKVRALNKLVSRIAP 1377



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)

Query: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503
            L   D     Q  +A  E  +TK+  L R+  +  T L+  +DV+   EK  +L+     
Sbjct: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079

Query: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1563
                        E  R E  +L +EN++L+N++                           
Sbjct: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102

Query: 1564 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1623
               V+QE  A +   +  +K+I  LK   ++   E   L+++N   +++L +LN R+ ++
Sbjct: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159

Query: 1624 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1683
                             QE    + + E  +V    L  SLE  +   + Q+  +Q+   
Sbjct: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200

Query: 1684 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
             L+ ELE + Q H+   L  S+  Q +  S        L+ ++A ++ L   V  + +  
Sbjct: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258

Query: 1741 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1797
            + E HR+ +++ EQ  +  + Q    + QL A++E+V+  E  ++N+ + +      L+ 
Sbjct: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317

Query: 1798 TQQEKEALKQEVMSLHKQLQNA 1819
             +Q ++  K +++     ++NA
Sbjct: 1318 -EQFEKNTKSDLLLKELYVENA 1338



 Score = 38.1 bits (87), Expect = 0.091
 Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)

Query: 799  QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 854
            Q  +Q GRE +++     + + + +E  +  D + +T   +SA+Q      Y QEL    
Sbjct: 333  QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387

Query: 855  EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 910
              Q+ +  Q   E+D+  Q+   A+    E +KE      T   +  ++ + LE+ Y+E 
Sbjct: 388  -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446

Query: 911  L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 959
            L    + +  ER+   +     R   E        +++ L +++      + R  +E  E
Sbjct: 447  LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506

Query: 960  VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1019
            V+ +   SE+LA +  + LE     + +   ++LLA E    A  +  + +  ++     
Sbjct: 507  VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566

Query: 1020 RLQSKIK 1026
             LQ++++
Sbjct: 567  ELQAELE 573



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)

Query: 1569 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1628
            QE +  Q  VE L ++  + +   ++ +  N E  ++       L++L ++  + L Q  
Sbjct: 384  QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443

Query: 1629 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1688
            +E  +    E E E+    E+  R +      V  L+AE + ++ +  +  +EN  L+ E
Sbjct: 444  RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503

Query: 1689 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1731
            +    EK+    R       DL        + + + +L+  E+   +LKE E    +L  
Sbjct: 504  IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563

Query: 1732 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1787
              D+L     LE   A + + + S        + QL     A    + N         L 
Sbjct: 564  RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621

Query: 1788 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1843
            M ++K    DLR   + K    ++E+ +L +  +    K          S L  Q+    
Sbjct: 622  MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677

Query: 1844 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1898
               L+ L  + Q+++W   E+LQ   +  + E         Q    L  +H  HL
Sbjct: 678  --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730



 Score = 35.8 bits (81), Expect = 0.45
 Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)

Query: 963  QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1008
            Q    EQLA+      ++  ++E+ +M +KLL +E++ +A  +  D              
Sbjct: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091

Query: 1009 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1057
                      R R E+    S   ++ KE++          S  +V+  +       LS 
Sbjct: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151

Query: 1058 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1105
                +LQ G++        EE+   +  L ++ E+ V+   + + +I +L+  L+ L   
Sbjct: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211

Query: 1106 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
                  P   ++  L+E   +  G      +     LQ+ R    + V   H L  L+ +
Sbjct: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271

Query: 1157 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1211
            + R          ++Q    E ++EE+E  ++     L+   +   E +E   +   L +
Sbjct: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331

Query: 1212 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1247
            +L +  A   RA     EK++       +L++K++ L ++
Sbjct: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371



 Score = 35.8 bits (81), Expect = 0.45
 Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)

Query: 362  SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 402
            S HQA     +  I+ L + +++VVR       + +KLR +L+             +E  
Sbjct: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223

Query: 403  KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 460
            ++L  S  +V   H  + +    +L+++    ++R+A L   L  + EQ  ++   QR E
Sbjct: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283

Query: 461  LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 520
             E++++   TEE      + L       +E  L E  +KL E      + ++N ++ L  
Sbjct: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330

Query: 521  KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
            K  +L   +A      +   + +   E+Q R+L+++V  L
Sbjct: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  225 bits (574), Expect = 3e-58
 Identities = 414/2007 (20%), Positives = 843/2007 (42%), Gaps = 320/2007 (15%)

Query: 351  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
            +L  E L+ +    + +L+S++ +   L+     + REK+KL+  L +++       +E+
Sbjct: 133  SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192

Query: 411  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEK 467
             +     ++  ++   + D   EE  + I+ L+ ++   ++++  + G   +++ + + +
Sbjct: 193  REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL--RNGPMNVDVLKPLPQ 250

Query: 468  AKTEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 526
             + +          + +EN   + E ++E+   +   E L  +++R  EN+L      + 
Sbjct: 251  LEPQAE------VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQ-ENLLKRCKETIQ 303

Query: 527  PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR----AQGRVLRLPLKNSP 582
                     +E+ T + +E E     LQ+Q+DE   ELE+ +    A+   L   L+++ 
Sbjct: 304  S-------HKEQCTLLTSEKE----ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352

Query: 583  S--EEVEANSGGIEPEHGLGSEECNPLNMSIEAELV--IEQMKEQHHRDICCLRLELEDK 638
            +  E++E + G +  E      E   +     A+L   I+QM  Q       LR + E  
Sbjct: 353  NLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE----LREQKEKS 408

Query: 639  VRHYEKQLDETVVSCKKAQE--------------NMKQRHENETHTLEKQISDLKNEIAE 684
             R   ++L++ + + +K +E               +++  E E  +L++++S +K E+ +
Sbjct: 409  ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468

Query: 685  L-----QGQAAVLKEAHHEATCRHEEE-KKQLQVKLEEEKTHLQEKLRLQHEMELK-ARL 737
            +     + Q A L++ H +   R E+E  K+LQ +  E +  ++  L       LK ++ 
Sbjct: 469  VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528

Query: 738  TQAQASFEREREGLQSSAW---TEEKVRGLTQELEQFHQE--QLTSLVEKHTLEKEELRK 792
             + Q S   E   LQ  A    +E K+R L QE E +     +L S +EK   E +   K
Sbjct: 529  KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 793  EL------------------LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 834
            +L                  +EKH+ EL+  + + +     +   ++ Q+Q++ +K+ E+
Sbjct: 589  DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 835  CESALQSL----EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE---AQELLKETLK 887
            CE   ++L    E  ++  ++++ E+  E+    + E + L+ E +E   A+  L+E L 
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708

Query: 888  REKTTSLVLTQEREMLEKTYKEH----LNSMVVERQQLLQDLEDLRNVSETQQSLL---S 940
              K  +  + QE E      K H    ++S++ E +  +Q  E        Q  LL    
Sbjct: 709  VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768

Query: 941  DQILELKSSH----KRELREREEVLCQAGAS-------------------EQLASQRLER 977
            D+ L+   +H    + +++  E  L QA A                    EQLA  + + 
Sbjct: 769  DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828

Query: 978  LEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM 1037
            L++E   ER  +  ++  +E   K  C   D  + ++   + +L+ +  EM+Q    L+ 
Sbjct: 829  LDLE--TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886

Query: 1038 LQSGCQVIGEEE--------VEGDGALSLLQQGE--------QLLEENGDVLLSLQRAHE 1081
            +       G +E        VE +  +  +++G+        Q L    D +  L   +E
Sbjct: 887  VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946

Query: 1082 QAVKENVKMATEISR----LQQRLQK--LEPGLVMSSCLDEPATEFF------------- 1122
               K   K   ++ +    +Q+ L+K  L+    +   L+  A E               
Sbjct: 947  TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006

Query: 1123 --GNTAEQTEPF--LQQNRTKQVEGVTRRH--VLSDLEDDEVRDLGSTGTSSVQRQEVKI 1176
               N+A  ++    L+ N+ +Q+E +T  H   L+D+     + L        +  E+++
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066

Query: 1177 EESEASVEGFSE------LENSEETRTESWELKNQ-------ISQLQEQLMMLCADCDRA 1223
            +E E  V    +       E  E  +  +W LK +       +++LQEQL    A  +  
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITW-LKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125

Query: 1224 SEKKQDLLFDVSVLK----KKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEEL 1272
            ++ +  L   +  L+    K LK    + E   + K+L E+  R+   L        EE 
Sbjct: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185

Query: 1273 RMMETRYDEALENNKELTAEVFRLQDELKKMEEV----TETFLSLEKSYDEVKIENEELN 1328
            + +++ ++++ ++ ++ + E  +L +EL    ++    TE  L   K+ + + I + + N
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA-KTNELINISSSKTN 1244

Query: 1329 VLVLRL---QGKIEKLQESV-VQRCDCCLWEASLENLEIEPDG---NILQLNQTLEECVP 1381
             ++ R+   Q +  K++E++ ++ C     EA L  L  E +    +  Q    LEE   
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304

Query: 1382 RVRSVHHVIEECKQENQYLE---GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE 1438
            +++S+   IE    E + L+   GN Q     K   I  L   +  +     +  + + E
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364

Query: 1439 ENTTLLGFQDK------HFQHQATIAELEL-----------EKTKLQELTRKLKERVTIL 1481
            +   +     +        Q+  +++E E            EK +L +  + L  +V  L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424

Query: 1482 VKQK-----------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENS 1530
             K+K           +  S  +K+ + +   H  Q T  E+Q ++EL   E+ +  ++ +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQH--QNTVKELQIQLELKSKEAYEKDEQIN 1482

Query: 1531 ILRNEITTLNE---------EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENL 1581
            +L+ E+   N+         ED  S ++    N   E   Q    ++ E+   QK +E +
Sbjct: 1483 LLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE-I 1541

Query: 1582 KKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTE-----MLCQKEKEPGNSAL 1636
            +     LK  NQQ D+E+ EL QK    QE  +E + R+ E     +  + +     + L
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL 1601

Query: 1637 EEREQE----KFNLKEELERCKVQSSTLVSSLEAELSEVK--IQTHIVQQENHLLKDELE 1690
            E +++E      ++K + E  K     L S   A+L+E+K   +  I   +  LL    E
Sbjct: 1602 ETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE 1661

Query: 1691 KMKQLHRCPD--LSDFQQKISS----VLSYNEKLLKEKEALSEELNSCVDKLAKSSLL-- 1742
            K +Q  +  +  LS+   K+      V    EKL   + + SE L   V + AK+     
Sbjct: 1662 KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL--IVPRSAKNVAAYT 1719

Query: 1743 -EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNL----EDTVQNVNLQMSRMKSDLRV 1797
             +    +    QK++E + + L+  L   ++ +Q +    E+TV + + +M     +  +
Sbjct: 1720 EQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSS-HFEMRCQYQERLI 1778

Query: 1798 TQQEKEALKQEVMSLHKQLQNA---GGKSWAPEIATH---PSGLHNQQKRLS----WDKL 1847
              +  EA + E  S+   LQ       K ++  +A H     G +N Q + +    +D +
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDV 1838

Query: 1848 DHLMNEEQ---QLLWQENERLQTMVQNTKA-------ELTHSREKVRQL----------- 1886
               + E++   Q+L Q+ + L + +   K        ELT   EK++ L           
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898

Query: 1887 --ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNS------- 1937
              E N   K + HL     ++  E +   L+ +    ++E+    +++ ++         
Sbjct: 1899 LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958

Query: 1938 -LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQ-QQACPMV 1995
              +QELE +  E +  +++++K +++ +E++H    +T       ++ QL Q +Q   M 
Sbjct: 1959 EHQQELEILKKEYDQEREEKIKQEQEDLELKH---NSTLKQLMREFNTQLAQKEQELEMT 2015

Query: 1996 PREQFLQLQRQLLQAERINQHLQE------ELENRTSETNTPQGNQEQLVTVMEERMIEV 2049
             +E   + Q   ++AE +  H +E      ++  +  +        E+++   EE M   
Sbjct: 2016 IKETINKAQE--VEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAK 2073

Query: 2050 EQKLKLVKRLLQEKVNQLKEQVSLPGH 2076
             + L+     LQ+K  Q  EQ   PG+
Sbjct: 2074 VRDLQTQLEELQKKYQQKLEQEENPGN 2100



 Score =  202 bits (514), Expect = 3e-51
 Identities = 403/1935 (20%), Positives = 822/1935 (42%), Gaps = 350/1935 (18%)

Query: 268  RQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIEN 327
            RQ+   L M+  + +  R+      T     R      +      +E+ L T Q+     
Sbjct: 371  RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK----- 425

Query: 328  SQEILKALDFSLDGNINLTELT-----LALENELLVTKNSIHQAALASFKAEIRHLLERV 382
            ++E  + L   +D  I   E T     ++L+ EL   K  +      S + +I  L    
Sbjct: 426  TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL---- 481

Query: 383  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 442
             Q + EKE  R + +  +KL++      +    A+E+     L+   E+ ++   AL+ E
Sbjct: 482  -QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE-E 539

Query: 443  LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN--AEKL 500
            L  +++ IL ++  +  +L+QE E  +T    +   L  SL+EN     +L  +  AEK 
Sbjct: 540  LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599

Query: 501  AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE- 559
               + +T  ++++   + + K         +  L  E+L  ++ +Y+ +   L+++ ++ 
Sbjct: 600  KHNKEITVMVEKHKTELESLK-------HQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652

Query: 560  -----------LQSELEEYRAQGRVLRLPLKNSPSEEVEAN-SGGIEPEHGLGSEECNPL 607
                        Q+ +EE   +  + +L +K +  E + +  S  ++  H L  EE + L
Sbjct: 653  KETLLKDKEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKL-EEELSVL 710

Query: 608  -----NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KAQENMK 661
                  M  E E  +++ K  H + +  +  E E  ++  EK L + +   +   +E  K
Sbjct: 711  KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770

Query: 662  QRHENETHTLEKQISDLKNEIAELQGQAAVL------KEAHHEATCRHEEEKKQLQVKLE 715
               E++ H +E   +D+K    ELQ  +A L      + A HE T  +EE+  QLQ KL 
Sbjct: 771  HLKEHQAH-VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829

Query: 716  EEKTH--LQEKLRLQHEMELKARLTQAQASFEREREGLQ----SSAWTEEKVRGLTQ--- 766
            + +T   L  K   + E + K   T+  A   + ++ +Q     ++  E+KV+ LTQ   
Sbjct: 830  DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889

Query: 767  -ELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM---ETECNRRTSQIEA 822
             +LE  ++EQ     ++  +EKE +  ++ E  ++E++   +K+   E   +    + E 
Sbjct: 890  SKLEDGNKEQ--EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947

Query: 823  QFQSD---CQKVTERCESALQSL-------EGRYRQELKDLQEQQREEKSQWEFEKDELT 872
            +F++     +KV ++ +   ++L       E + ++EL++   +  +++ Q+  +  E+ 
Sbjct: 948  KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007

Query: 873  QE----CAEAQELLKETLKREKTTSLVLTQEREMLE--KTYKEHLNSMVVERQQL--LQD 924
            Q      ++A   L ET ++E+  SL     RE+ +    +++ LN    E Q++  +Q 
Sbjct: 1008 QANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066

Query: 925  LEDLRNVSETQQSLL---------SDQILELKSSHKRE---LREREEVLCQAGA------ 966
             E  + V+E +Q +L         + +I  LK    ++   L E +E L Q  A      
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126

Query: 967  -SEQLASQRLERLEMEHDQERQE---MMSKLLAMENIHKATCETADRERAEMSTEISRLQ 1022
              E      LE+LE++ ++  +E   +  +L+ ++ +       A+ ++ ++S   S+L+
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML-------AEEDKRKVSELTSKLK 1179

Query: 1023 SKIKEMQQATSPLSMLQSGCQ--VIGEEEVEGDGALSL---LQQGEQLLEENGDVLLSLQ 1077
            +  +E Q   S         +   +  +++  + A+ L    ++ E LLE   + L+++ 
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239

Query: 1078 RAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNR 1137
             +   A+       + IS  Q R  K++  L++ +C              Q     ++  
Sbjct: 1240 SSKTNAI------LSRISHCQHRTTKVKEALLIKTCT-------VSELEAQLRQLTEEQN 1286

Query: 1138 TKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELEN------ 1191
            T  +      H L + ++++++ + +   S V  +E   +E     +  SE E+      
Sbjct: 1287 TLNISFQQATHQLEE-KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345

Query: 1192 ---SEE------TRTESWELKNQISQLQEQLMMLCADCDRA---SEKK------------ 1227
               SE        + E  E K +IS L +QL  L      +   SEK+            
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405

Query: 1228 ---------QDLLFDVSVL-KKKLKMLERIPEASPKY----KLLYEDVSRENDCLQEELR 1273
                     QDL F V  L K+K+  LE++ + S K+    K      ++  + ++E   
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465

Query: 1274 MMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNV-LVL 1332
             +E +  EA E ++++      L  + K+ +      L  E   D+ K+E +E N+   L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFD-----CLKGEMEDDKSKMEKKESNLETEL 1520

Query: 1333 RLQ-GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQ-LNQTLE----ECVPRVRSV 1386
            + Q  +I +L++ + Q+            +EIE    +L+  NQ  +    E V +++  
Sbjct: 1521 KSQTARIMELEDHITQK-----------TIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569

Query: 1387 HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF 1446
              + EE  ++N+  E   ++L     +++  +   ++T ++     N  +  +   L   
Sbjct: 1570 QELGEE--KDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625

Query: 1447 QDKHFQHQATIAELELEK-TKLQELTRKLKERVTILVKQKDVLSHGEKEEE-----LKAM 1500
            +D+          LE E   KL EL RK ++++  + KQ  +LS  E++EE      ++ 
Sbjct: 1626 EDR----------LESESAAKLAELKRKAEQKIAAIKKQ--LLSQMEEKEEQYKKGTESH 1673

Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGT------LN 1554
            + +L     E +++V +L    EKL+   S+  ++  TL    S  N+   T        
Sbjct: 1674 LSELNTKLQEREREVHIL---EEKLK---SVESSQSETLIVPRSAKNVAAYTEQEEADSQ 1727

Query: 1555 GSQEEMWQKTETVKQENAA-----VQKMVENLKKQIS---ELKIKNQQ--LDLENTELSQ 1604
            G  ++ +++  +V Q N       +Q++ +  ++ +S   E++ + Q+  + LE+ E  Q
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ 1787

Query: 1605 KNSQN-----QEKLQELNQRLTEMLCQK-EKEPGNSALEEREQEKFNLKEELERCKVQSS 1658
               Q+     QE+L+E N++ + ++ Q  EKE G + +    Q K NL+           
Sbjct: 1788 HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI----QAKQNLE----------- 1832

Query: 1659 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1718
             +   ++  L E ++   I++Q          K+K+L  C                   L
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQ----------KIKELDSC-------------------L 1863

Query: 1719 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLE 1778
            +++KE    E+     K  K   L+      K  +   E+     KS LV  Q K+    
Sbjct: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV--QPKL---- 1917

Query: 1779 DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQ 1838
              + N+  Q + ++  L   ++EK+ L +E++ L K L+    +        H   L   
Sbjct: 1918 --LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE--------HQQELEIL 1967

Query: 1839 QKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE-----------KVRQLE 1887
            +K    ++ + +  E++ L  + N  L+ +++    +L    +           K +++E
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027

Query: 1888 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV-SQMNSLEQELETIH 1946
            + LL  HQ+  N    +    ++   LKR   ++++       ++ +++  L+ +LE + 
Sbjct: 2028 AELLESHQEETNQ--LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ 2085

Query: 1947 LENEGLKKKQVKLDEQ---------LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
                  KK Q KL+++         +ME+Q   +  T   S    D +L +Q+      R
Sbjct: 2086 ------KKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS----DSKLKEQEF-----R 2130

Query: 1998 EQFLQLQRQLLQAER 2012
            EQ   L+ +L + E+
Sbjct: 2131 EQIHNLEDRLKKYEK 2145



 Score =  164 bits (415), Expect = 8e-40
 Identities = 338/1662 (20%), Positives = 686/1662 (41%), Gaps = 296/1662 (17%)

Query: 606  PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
            P +M  EAE ++      +   +      +E  +  Y  +  E V + +  Q   K+   
Sbjct: 117  PSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176

Query: 666  NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL 725
              + + +K +  +     ELQ      K    E     EE+ + + V L+ + + L+++L
Sbjct: 177  ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISV-LQTQVSLLKQRL 235

Query: 726  R--------------LQHEMELKARLTQAQASFE---------REREGLQSSAWTEEKVR 762
            R              L+ + E+  +    ++  E         +  E LQ     +E + 
Sbjct: 236  RNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL 295

Query: 763  GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE-------KMETECNR 815
               +E  Q H+EQ T L    T EKE L+++L E+ Q EL++ ++       K+ T+   
Sbjct: 296  KRCKETIQSHKEQCTLL----TSEKEALQEQLDERLQ-ELEKIKDLHMAEKTKLITQLRD 350

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLE------GRYRQELKDLQEQQREEKSQWEFEKD 869
              + IE   Q     + E      ++LE       + R  +K +  Q  E + Q E  + 
Sbjct: 351  AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410

Query: 870  ELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR 929
               +E  +A    ++T +  +     + ++ + +EKT +E   S+  E  ++ Q++ D+ 
Sbjct: 411  AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470

Query: 930  NVSETQQSLLSDQILELKSSHKREL-------------RERE--------------EVLC 962
              S        +QI +L+  H++EL             RERE              E L 
Sbjct: 471  KKSS------EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK 524

Query: 963  QAGASEQLASQRLERLEMEH--------------DQERQEMMSKLLAME----------- 997
             +   EQ  S  LE LE++                QE +   +++L +E           
Sbjct: 525  ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584

Query: 998  NIHKATCETADRERAEMSTEISRLQSK-------IKEMQQA--TSPLSMLQSGCQVIGEE 1048
            N  K      + E+ + + EI+ +  K       +K  Q A  T  L +L+   Q   E+
Sbjct: 585  NQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEK 644

Query: 1049 EVEGDGALSLLQQGEQLLEENGDVLLS-LQRAHEQAVK-------ENVKMATEISRLQQR 1100
              E        Q+ E LL++   +  + ++  +E+ ++       E   +++E+S + + 
Sbjct: 645  LRE-----KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699

Query: 1101 LQKLEPGL-VMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLS-----DLE 1154
              KLE  L V+    D+   E      EQ     + +  +QV+ + + H +S        
Sbjct: 700  RHKLEEELSVLKDQTDKMKQELEAKMDEQ-----KNHHQQQVDSIIKEHEVSIQRTEKAL 754

Query: 1155 DDEVRDLG-----------------STGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1197
             D++  L                      + ++R E +++++ A ++ F   +++   +T
Sbjct: 755  KDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT 814

Query: 1198 ESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLL 1257
            +++E   Q++QLQ++L+ L  + +R    KQ  + +V   KK   +   +     + + L
Sbjct: 815  KAYE--EQLAQLQQKLLDL--ETERILLTKQ--VAEVEAQKK--DVCTELDAHKIQVQDL 866

Query: 1258 YEDVSRENDCLQEELRMMETRYDEALEN-------NKELTAE----VFRLQDELKKMEEV 1306
             + + ++N  ++++++ +   Y+  LE+        K++  E    + ++++  KK  E+
Sbjct: 867  MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926

Query: 1307 TETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD 1366
                LS ++  D + I NEE        + K+EK+++   +       + +L+   ++ +
Sbjct: 927  LTQKLSAKE--DSIHILNEEYETKFKNQEKKMEKVKQKAKE------MQETLKKKLLDQE 978

Query: 1367 GNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE--IAWLHGTIQT 1424
                +L + LE         +  +E  ++E Q+   N ++LE  +A+   I+     ++T
Sbjct: 979  A---KLKKELE---------NTALELSQKEKQF---NAKMLEMAQANSAGISDAVSRLET 1023

Query: 1425 HQ-ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1483
            +Q E+     +V   E   ++   +K    QA   + E+ + +LQE     KE+    +K
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ-EIHEIQLQE-----KEQEVAELK 1077

Query: 1484 QKDVLSHGEKEEE------LKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
            QK +L   EKEE       LK        T +E+Q++++        L Q+ + L+  + 
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137

Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
             L E D   +LK  T    QE++ +     +++   V ++   LK    E +      + 
Sbjct: 1138 KL-EVDLNKSLKENTF--LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194

Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLK--------EE 1649
             N  L  K+ + ++  +EL  +L ++ C+K +    + LE +  E  N+           
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQL-DICCKKTE----ALLEAKTNELINISSSKTNAILSR 1249

Query: 1650 LERC-----KVQSSTL-----VSSLEAELSEVKIQTHIV----QQENHLLKDELEKMKQL 1695
            +  C     KV+ + L     VS LEA+L ++  + + +    QQ  H L+++  ++K +
Sbjct: 1250 ISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSM 1309

Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKE---KEALSEELNSCVDKLAKS-SLLEHRIATMKQ 1751
                     +  I S+++  E L KE   ++  + E  SC+ +L K  S   + +  MK+
Sbjct: 1310 ---------KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360

Query: 1752 EQKSWEHQSASLKSQLVASQEKVQN------LEDTVQNVNLQMSRMKSDLRVTQQE---- 1801
            E K  + + +SL  QL     ++QN       E  + ++  Q    K +L    Q+    
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420

Query: 1802 KEALKQEVMSLHKQLQNAGGK--SWAPEIATHPSGLHNQQKRLS-----WDKLDHLMNEE 1854
             + L +E +S  +Q+ +   K   W  +  +  +   N  K L        K  +  +E+
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480

Query: 1855 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL----------LPKHQKHLNPSG-- 1902
              LL +E ++        K E+   + K+ + ESNL          + + + H+      
Sbjct: 1481 INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE 1540

Query: 1903 -------TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1955
                     N  +Q+ +  K    + Q  Q     K +++   E+++ T  LEN+    K
Sbjct: 1541 IESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT--LENQVYSMK 1598

Query: 1956 QVKLDEQLMEMQHLR-STATPSPSPHAWDLQLLQQQACPMV-----PREQFLQLQRQLL- 2008
              +L+ +  E++H+  S  +      A + +L  + A  +        ++   +++QLL 
Sbjct: 1599 -AELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657

Query: 2009 QAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVE 2050
            Q E   +  ++  E+  SE NT    +E+ V ++EE++  VE
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699



 Score =  162 bits (409), Expect = 4e-39
 Identities = 328/1521 (21%), Positives = 631/1521 (41%), Gaps = 238/1521 (15%)

Query: 634  ELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLK 693
            E ED V + +    E ++   +  E     +  +   L      L+ E  +LQG   +L 
Sbjct: 123  EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG---ILS 179

Query: 694  EAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQ 752
            ++  ++  R  E +++LQ+  ++ K HLQE+      E +    + Q Q S  ++R  L+
Sbjct: 180  QSQDKSLRRIAELREELQMD-QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR--LR 236

Query: 753  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
            +     + ++ L Q                      E + E+  K +    +G   +E  
Sbjct: 237  NGPMNVDVLKPLPQL---------------------EPQAEVFTKEENPESDGEPVVEDG 275

Query: 813  CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 872
             + +T +   Q     + + +RC+  +QS    ++++   L      EK   + + DE  
Sbjct: 276  TSVKTLETLQQRVKRQENLLKRCKETIQS----HKEQCTLLTS----EKEALQEQLDERL 327

Query: 873  QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 932
            QE     E +K+    EKT  +   ++ + L +  ++    ++ E ++ + +  +++   
Sbjct: 328  QEL----EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKE-- 381

Query: 933  ETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 992
                    ++I +L+S  K+   + EE+  Q   SE+ A + LE+  +   Q+ +E   K
Sbjct: 382  --------EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA-LSTAQKTEEARRK 432

Query: 993  LLA-MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
            L A M+   K   +T++ ER  +  E+SR++ ++ ++ + +S             EE++ 
Sbjct: 433  LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------EEQI- 478

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                  L +  E+ L      L    +  E+  +E +K+A E S+ +      E     S
Sbjct: 479  ----AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSS--- 1168
              L+E   +      E         R  Q E  T R  + +LE    + L      S   
Sbjct: 535  LALEELELQKKAILTESENKL----RDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590

Query: 1169 -----VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI--SQLQEQLMMLCADCD 1221
                  ++ +   E +    +  +ELE+ +  +   W  K Q+   Q Q ++  L   C+
Sbjct: 591  AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650

Query: 1222 RASE---KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1278
            +  E   K ++++F   + +   K LE++                  D  Q EL  + + 
Sbjct: 651  QEKETLLKDKEIIFQAHIEEMNEKTLEKL------------------DVKQTELESLSSE 692

Query: 1279 YDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1338
              E L+   +L  E+  L+D+  KM++  E  +  +K++ + ++++             I
Sbjct: 693  LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS-------------I 739

Query: 1339 EKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ 1398
             K  E  +QR +  L +             I QL   L+E    ++     +E  + + +
Sbjct: 740  IKEHEVSIQRTEKALKD------------QINQLELLLKERDKHLKEHQAHVENLEADIK 787

Query: 1399 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
              EG  Q        + +      Q++Q     Q +           ++++  Q Q  + 
Sbjct: 788  RSEGELQ--------QASAKLDVFQSYQSATHEQTK----------AYEEQLAQLQQKLL 829

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE-ELKAMMHDLQITCSEMQQKVEL 1517
            +LE E+  L       K+   +  ++KDV +  +  + +++ +M  L+   SEM+QKV+ 
Sbjct: 830  DLETERILL------TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883

Query: 1518 LR--YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1575
            L   YES KL+  N         L E++   N+ L    G ++E+    E + Q+ +A +
Sbjct: 884  LTQVYES-KLEDGNKEQEQTKQILVEKE---NMILQMREGQKKEI----EILTQKLSAKE 935

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +  L ++  E K KNQ+  +E  ++ QK  + QE L+   ++L +   + +KE  N+A
Sbjct: 936  DSIHILNEEY-ETKFKNQEKKME--KVKQKAKEMQETLK---KKLLDQEAKLKKELENTA 989

Query: 1636 LEEREQEK-FNLKEELERCKVQS---STLVSSLEAELSE-VKIQTHIVQQE--------N 1682
            LE  ++EK FN K  LE  +  S   S  VS LE    E ++  T + ++E         
Sbjct: 990  LELSQKEKQFNAK-MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048

Query: 1683 HLLKDELEKMKQLHRC------PDLSDFQQKISSVLSYNEKLLKEKEALSEE-------L 1729
              L  + E+++++H         ++++ +QKI       E++ KE   L EE       L
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108

Query: 1730 NSCVDKLAKSSLLEHRIATMKQEQKS-WEHQSASLKSQLVAS---QEKVQNLEDTVQNVN 1785
            N   ++L + S   + +A  + + K+  E     L   L  +   QE++  L+   +   
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168

Query: 1786 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLS 1843
             ++S + S L+ T +E ++LK      +K L++     K  + E+A        + + L 
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228

Query: 1844 WDKLDHLMN---EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL--LPKHQKHL 1898
              K + L+N    +   +       Q      K  L      V +LE+ L  L + Q  L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288

Query: 1899 NPS---GTMNPTEQEKL---------SLKRECDQFQKE----QSPANRKVSQMNSLEQEL 1942
            N S    T    E+E           SL  E +  QKE    Q  A+ K S +  L++EL
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348

Query: 1943 ----ETIHLENEGLKKKQVK---LDEQLMEMQ-HLRSTATPSPSPHAWDLQLLQ--QQAC 1992
                  + L  E LK+K+V+   L +QL ++   L+++ + S    A      Q  ++ C
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408

Query: 1993 PMVPREQFLQLQRQLLQAERINQHLQ-EELENRTSE-TNTPQGNQEQLVTVMEERMIEVE 2050
             ++ + Q L  +   L  E+I+   Q ++  N+ SE     Q    Q    ++E  I++E
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468

Query: 2051 QKLKLVKRLLQEKVNQLKEQV 2071
             K K       E++N LKE++
Sbjct: 1469 LKSKEAYE-KDEQINLLKEEL 1488



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 80/334 (23%), Positives = 142/334 (42%), Gaps = 61/334 (18%)

Query: 323  EGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERV 382
            E + +  E L+AL   +DG    TEL L    E     + +    L++ +A+   L  ++
Sbjct: 1875 EELTSKYEKLQALQ-QMDGRNKPTEL-LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932

Query: 383  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 442
                REK+KL  ++ + +K                      +LR L +E+++ +  LK E
Sbjct: 1933 AGAEREKQKLGKEIVRLQK----------------------DLRMLRKEHQQELEILKKE 1970

Query: 443  LRKEREQILQQAG-----KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENA 497
              +ERE+ ++Q       K    L+Q + +  T+       L +++KE      E+   A
Sbjct: 1971 YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEV--EA 2028

Query: 498  EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 557
            E L  ++  TN+L + +    AEK  DL  ++  +   EE L     E   + R LQ Q+
Sbjct: 2029 ELLESHQEETNQLLKKI----AEKDDDLKRTAKRY---EEILDAREEEMTAKVRDLQTQL 2081

Query: 558  DELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVI 617
            +ELQ + ++   Q             EE   N      E  L ++      +  +++L  
Sbjct: 2082 EELQKKYQQKLEQ-------------EENPGNDNVTIME--LQTQLAQKTTLISDSKLKE 2126

Query: 618  EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVV 651
            ++ +EQ H         LED+++ YEK +  T V
Sbjct: 2127 QEFREQIHN--------LEDRLKKYEKNVYATTV 2152


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  212 bits (540), Expect = 3e-54
 Identities = 399/1914 (20%), Positives = 799/1914 (41%), Gaps = 286/1914 (14%)

Query: 357  LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA 416
            L ++  + +A L     E+  LL +  +   + EK+   L +  ++     +E+ +H A+
Sbjct: 270  LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329

Query: 417  IERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQR-LELEQEIEKAKTEENYI 475
            + R  +     L +  K+    +   + +E + I Q +G +  LEL+  I    ++ +Y 
Sbjct: 330  LSRNAQEEKLSLQQVIKD----ITQVMVEEGDNIAQGSGHENSLELDSSI---FSQFDYQ 382

Query: 476  RDRLALSLKEN--SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 533
                AL+L  +  +R    + +  ++LA  +   N LQ        ++    +       
Sbjct: 383  DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ--------QQHDQWEEEGKALR 434

Query: 534  LQEERLTQMRNEYERQCRVLQDQVDELQSE-------LEEYRAQGRVLRLPLKNSPSEEV 586
             + ++LT  R+    Q   LQ +VD L  E        EE R Q  VL           V
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494

Query: 587  EANSGGIEPEHGLGSEECNPLNMSI-------EAELVIEQMKEQHHRDICCLRLELEDKV 639
            E    G +   G   E+   L++++       E  + +E  + +   ++  LR  LE   
Sbjct: 495  ELQLQG-DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS- 552

Query: 640  RHYEKQL-----DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ-------- 686
             H E +L      E   +  +A++++ +   +E +TL+ +++DL+    +L         
Sbjct: 553  -HLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEALAL 610

Query: 687  -----GQAAVLKEAHHEATCRH----EEEKKQLQVKLE----------EEKTHLQEKLRL 727
                  Q  +  E  +++ C      E+ +  LQV L           E+ THL+ +L+ 
Sbjct: 611  DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670

Query: 728  QHE--MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ-------LTS 778
              E   EL+A L   Q   E  ++ L  S   +E     T +LEQ HQE          +
Sbjct: 671  AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEVLARA 727

Query: 779  LVEKHTLEKE----ELRKELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTE 833
            + EK  L +E    E+R + +E+ +++L E  + + +      +S  EAQ Q+   +VT+
Sbjct: 728  VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787

Query: 834  -RCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 889
             + E  +Q++   +   + E++ L+ +   E+SQ E E+D   ++ A+A++  K  L+++
Sbjct: 788  GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847

Query: 890  KTT-SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKS 948
            K      + Q RE  EK    H       +Q+L + LE L             + +EL+ 
Sbjct: 848  KAAHEKEVNQLREKWEKERSWH-------QQELAKALESLER-----------EKMELEM 889

Query: 949  SHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD 1008
              K +  E E +  Q       A   L ++++E ++ER  ++  LL  +       +  +
Sbjct: 890  RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949

Query: 1009 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE-EEVEGDGALSLLQQGEQLLE 1067
            R R +M  +      K+KE +      + LQ   + + E      D   +L ++   LL+
Sbjct: 950  RLRQDMKVQ------KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003

Query: 1068 ENGDVLLSL-------------QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS--- 1111
            +  D+   +             QR  EQ V+E ++   E +R+Q+ L++ +  L +S   
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063

Query: 1112 -------------------SCLDEPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRR-H 1148
                               S L +   E  G   E   Q E   Q+ + K+ + + +   
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123

Query: 1149 VLSDLEDDEVRD------LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1202
            +L +LE   + +      L +    + Q Q +++  +E+ +E  +  +          +L
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 1203 KNQISQLQEQLMMLCADCDRAS------------EKKQDLLFDVSVLKKKLKMLERIPEA 1250
             +  S LQ+ L  +C      S            E  Q+    +      L  L     A
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 1251 SPKYKLLYEDV---SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL------- 1300
            S  +K L++D+    +  D L+++++ +E R  +      ++  E+  LQ +L       
Sbjct: 1243 SALHK-LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 1301 -----------KKMEEVTETFLSLEKSYDEVKI-------ENEELNVLVLRLQGKIEKLQ 1342
                        ++ E+ ET  SL+      ++       E E L      L  ++E LQ
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQL-NQTLEECVPRVRSVHHVIEECKQENQYLE 1401
             +VV+          LE  ++    + L+L N+ +E    R +++    E    + + L+
Sbjct: 1362 AAVVEARAQASAAGILEE-DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420

Query: 1402 GNTQLLEKVKA---HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
             N  LL +  A    E+  L G IQ  +++  +Q   +   +  L     +    Q  I 
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
            ELE  ++ L+ L   ++ER   L  Q++ +   EK+ E +  + + Q+   E+++K +++
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--ELEKKDQMI 1538

Query: 1519 RYESEKLQQ-ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ-ENAAVQK 1576
              +  ++Q  +  ++  E   L  E++   ++       Q+++ ++ E  ++ +  A+  
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTH 1592

Query: 1577 MVENLKKQISELKIKNQQL-DLE--NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGN 1633
            +  +L+++  EL+ ++ Q+ DLE  +T L+++  +  ++++   +++ E+  Q++KE   
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL--QRQKEHLT 1650

Query: 1634 SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI-----------QTHIVQQE- 1681
              LE R+QE    KE ++  + Q +     LE +L ++K+           Q  ++Q+  
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710

Query: 1682 ------NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDK 1735
                  +   +  LE MK +     L D ++++     +  +L + K+ L ++L     K
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765

Query: 1736 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1795
            + ++SLL      + Q     E +   L+ QL  ++E+ +  E ++Q+   Q+   +  L
Sbjct: 1766 VGETSLL------LSQR----EQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRAL 1812

Query: 1796 RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH-----L 1850
                QE EAL+QE      Q +    K+ A + A   +  H   K    +  DH      
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HMTLKERHGELQDHKEQARR 1870

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKH-----------LN 1899
            + EE  +  +  + L+ ++ + +AE     + +  L+     + Q+H           L 
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930

Query: 1900 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1959
                +   +QE  +L+ E  Q  + Q  A R  ++  +L++ L   H   +G  K+Q  L
Sbjct: 1931 AQAVLKERDQELEALRAE-SQSSRHQEEAAR--ARAEALQEALGKAHAALQG--KEQHLL 1985

Query: 1960 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2019
            ++  +      STAT   S  A      Q +      R Q  ++Q Q L+ +   Q LQ+
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQ 2042

Query: 2020 ELENRTSETNTPQGNQEQLVTVMEERMIE--VEQKLKLVKRLLQEKVNQLKEQV 2071
             L  R  E    Q  ++ L   + +R+ E  +++K  L +   +E++  L + V
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSV 2096



 Score =  202 bits (515), Expect = 2e-51
 Identities = 356/1733 (20%), Positives = 707/1733 (40%), Gaps = 269/1733 (15%)

Query: 353  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 412
            E E LV + +  +  L + + + + L E++  +   KE L S L +A++  S++      
Sbjct: 730  EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789

Query: 413  HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQ---AGKQRLELEQEIEKAK 469
                I+      + +  E  +  +  LK EL  ER Q  Q+   A +Q  + EQE + A 
Sbjct: 790  LEVQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844

Query: 470  TEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSS 529
             ++    ++    L+E  + E E   + ++LA+      + +  LE  L E+  +++   
Sbjct: 845  EQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902

Query: 530  AEFFLQEER------LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS 583
            A+   +EER      L QM+ E E++   L + + + Q EL +   Q   LR  +K    
Sbjct: 903  AQ--REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960

Query: 584  EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCL----------RL 633
            +E E          G+   +        EA+  +++   QH  D+  L          ++
Sbjct: 961  KEQETT--------GILQTQLQ------EAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006

Query: 634  ELEDKVRHYEKQL----DETVVSCKKAQENMKQRHENET--HTLEKQISDLKNEIAELQG 687
            +L+ +V   + QL    D   +  ++ QE +++  E       LE++ + L   + E + 
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066

Query: 688  QAAVLKEA----HHEATCRHEE------EKKQLQVKLEEEKTHLQEKLR--LQHEMELKA 735
            +  VL+EA      E +   ++      E+K+L  ++E  +  ++EK    L  E +L  
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL-- 1124

Query: 736  RLTQAQASFEREREGLQSSAWTEE--------KVRGLTQELEQFHQEQ------------ 775
             L + +AS   E++ L++S W +E        ++R    +LE    EQ            
Sbjct: 1125 -LEELEASHITEQQ-LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 776  --LTSLVEKHTLEKEELRKEL------------LEKHQRELQE-----------GREKME 810
              L S +++      E R EL            LE  Q   +              E + 
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 811  TECNR------RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ---QREEK 861
            +  ++      +T Q     +   QK+ ER     ++ + +   EL+DLQ Q    +EEK
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT-EAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 862  SQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKTYK------EHLN 912
            S+WE +++ L  E  E  E    L+  L+R +   +    ERE+L+   +      EHL 
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361

Query: 913  SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE--LREREEVLCQAGASEQL 970
            + VVE +        L     T +S L  +  E++S  +R   L+E+ E+    G + Q 
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421

Query: 971  ASQRLERLEMEHDQERQEMMSKLLAMEN---IHKATCETADRERAEMSTEISRLQSKIKE 1027
                L +   E ++E + +  ++  +E    + KA  E    +  + + E+   Q +I+E
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481

Query: 1028 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1087
            +++  S L  L    Q       E +  L++ ++  + LE++ +   + +   E  + E 
Sbjct: 1482 LEKCRSVLEHLPMAVQ-------EREQKLTVQREQIRELEKDRE---TQRNVLEHQLLEL 1531

Query: 1088 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1147
             K    I   + ++Q L+  LV   CL     E       Q +   +    ++ + V   
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591

Query: 1148 HVLSDLED---------DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTE 1198
            H+  DLE+          ++ DL S  T   +  + + +E ++  E   EL+  +E  T+
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651

Query: 1199 SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1258
              E ++Q   LQ++ + +  D       +Q  + +  + + KL + ER  E + + +L+ 
Sbjct: 1652 DLERRDQELMLQKERIQVLED----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707

Query: 1259 EDV------SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM-----EEVT 1307
            E        S+      E ++++    ++ +E  +E   E+  L+D+L++       +V 
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767

Query: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1367
            ET L L +   E+ +  ++L     R QG+++               E SL++   E   
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEA--REQGELK---------------EQSLQSQLDEAQR 1810

Query: 1368 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQTHQ 1426
             + Q +Q LE      +      E  K++   L+G  +     +AH  +   HG +Q H+
Sbjct: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHK 1865

Query: 1427 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD 1486
            E+ R   + +  E   +   ++        + +L  E  + ++    L+++     ++ +
Sbjct: 1866 EQARRLEEELAVEGRRVQALEE-------VLGDLRAESREQEKALLALQQQCAEQAQEHE 1918

Query: 1487 VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1546
            V +   ++  L+A     Q    E  Q++E LR ES+  + +    R     L E    +
Sbjct: 1919 VETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973

Query: 1547 NLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 1606
            +     L G ++ + ++ E  +   A+   +  +L    +  +   + L ++  E+  ++
Sbjct: 1974 H---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030

Query: 1607 SQNQEKLQELNQRLT----EMLCQKEKEP------GNSALEEREQEKFNLKEELERCKVQ 1656
             + QE +Q+L Q L     E+  Q+E+E            E   QEK NL +E E  +++
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090

Query: 1657 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1716
                 S  E +L+  + +  I++      ++ LE +   H+   + +   K+ S+     
Sbjct: 2091 GLHQ-SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL---EP 2146

Query: 1717 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1776
            +L +E E L   L             E R    +++ +      A  K+ + + QE    
Sbjct: 2147 RLQRELERLQAALRQT----------EAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196

Query: 1777 LEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLHKQLQNAG------GKSWAPEI 1828
            L+ +V   + +  R++ +L +T++  EKE L     +   +L + G      G+    E 
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256

Query: 1829 ATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLES 1888
               P G+  Q  R    +L+HL     +L                           +++ 
Sbjct: 2257 EPSPDGMEKQSWR---QRLEHLQQAVARL---------------------------EIDR 2286

Query: 1889 NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1941
            + L +H   L    T+   E+E+  LKRE  +  +  S    K +  +  +Q+
Sbjct: 2287 SRLQRHNVQLR--STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337



 Score =  195 bits (496), Expect = 3e-49
 Identities = 373/1848 (20%), Positives = 765/1848 (41%), Gaps = 236/1848 (12%)

Query: 326  ENSQEILKALDF----SLDGNINLTELTLA--LENELLVTKNSIHQAALASFKAEIRHLL 379
            E  QE+L  L+     SL   I L E   +  LE ELL  + +   AALA  +  I  L 
Sbjct: 522  ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASE---VDDHHAAIERRNEYNLRKLD--EEYKE 434
               + +  E   LR+   K   L   +A +   ++     +E  N+    +++  E+ + 
Sbjct: 582  SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641

Query: 435  RIAALKNELRKEREQI----------LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 484
             +     E  K RE +          LQ+A +   EL+ ++   + E+  I+ +L+ S  
Sbjct: 642  ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701

Query: 485  ENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN 544
            +      +L +  ++    E +  +  +  E ++ EK        A   ++ + + + R 
Sbjct: 702  QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK--------AALEVRLQAVERDRQ 753

Query: 545  EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 604
            +   Q + L    + L+S L E + Q  V+ +        EV+  +     E   G   C
Sbjct: 754  DLAEQLQGLSSAKELLESSLFEAQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRC 810

Query: 605  NPLNMSIEAELVIEQMKEQHHRDICCLRLE----LEDKVRHYEKQLDETVVSCKKAQENM 660
              L +  E     EQ ++   R +     E    LE +   +EK++++     +K +   
Sbjct: 811  LKLELDTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869

Query: 661  KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
            +Q       +LE++  +L+  + E Q +   ++    E   + E    Q+Q++ E+E+  
Sbjct: 870  QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929

Query: 721  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
            L E L     ++ +  L  A    ER R+ ++     E++  G+ Q   Q  Q +L    
Sbjct: 930  LLETL-----LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984

Query: 781  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
             +H   +++L    L++    L + +  ++ +     SQ+ A  Q D Q++ E+      
Sbjct: 985  RQH---RDDL--AALQEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQ------ 1031

Query: 841  SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
                  +++L++ QE  R +K + E EK  LT    E ++ L   L  ++  S+     R
Sbjct: 1032 ----EVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKEQRL---LVLQEADSI-----R 1078

Query: 901  EMLEKTYKEHLNSMVVERQQLLQDLEDLR-NVSETQQSLLSDQ---ILELKSSHKRELRE 956
            +      ++ +     E+++L   +E LR  V E +   L+ +   + EL++SH  E + 
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R  +  Q   + QL      +L +   + + E ++      N  +A        +A++++
Sbjct: 1139 RASLWAQEAKAAQL------QLRLRSTESQLEALAAEQQPGNQAQA--------QAQLAS 1184

Query: 1017 EISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS- 1075
              S LQ  +  + ++   LS        +   E + +GA SL ++G  L   + + + S 
Sbjct: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244

Query: 1076 LQRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1133
            L + H+   K      T+ +R  L+ ++QKLE  L      D  A +   +T  Q    L
Sbjct: 1245 LHKLHQDLWK------TQQTRDVLRDQVQKLEERLT-----DTEAEKSQVHTELQD---L 1290

Query: 1134 QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
            Q+  ++  E  ++     +  + E+ +L  T  +S+Q +  + E      +G  EL  + 
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGERELLQAA 1349

Query: 1194 ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK 1253
            +       L  Q+  LQ  ++   A    A   ++DL    S LK K + +E   E +  
Sbjct: 1350 KE-----NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404

Query: 1254 YKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF-LS 1312
             +   E    +   LQE L ++     E  E  + L  ++  L+ + +  +   E   L 
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 1313 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1372
            L+K   EV ++ E++  L  + +  +E L  +V +R          + L ++ +    Q+
Sbjct: 1465 LKKRNQEVDLQQEQIQELE-KCRSVLEHLPMAVQER---------EQKLTVQRE----QI 1510

Query: 1373 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ 1432
             +  ++   +   + H + E ++++Q +E     ++ +K   +      ++         
Sbjct: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE--------- 1561

Query: 1433 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK----DVL 1488
                LEEN   +  Q K  +      + E ++  L  LT  L+ER   L  Q     D+ 
Sbjct: 1562 ----LEENHHKMECQQKLIKELE--GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615

Query: 1489 SHG--------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLN 1540
            SH         E+++E+K+    ++    E+Q++ E L  + E+  QE  + +  I  L 
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671

Query: 1541 E---------EDSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
            +         E+ +  +KL        L   ++ M ++ E  K  + A +  +E++K   
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK--- 1728

Query: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA--LEEREQEK 1643
              L +++++ ++E  +      ++  +LQEL  +L + L    ++ G ++  L +REQE 
Sbjct: 1729 --LILRDKEKEVECQQ------EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLS 1702
              L+++L+  + Q      SL+++L E +       QE   L+ E ++ + Q  R  + +
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE-HRIATMKQEQKSWEHQSA 1761
            D    +   L      LKE+    ++      +L +   +E  R+  +++       +S 
Sbjct: 1841 D---ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897

Query: 1762 SLKSQLVASQEKV--QNLEDTVQNVNLQMSRMKSD--LRVTQQEKEALKQEVMSLHKQ-- 1815
              +  L+A Q++   Q  E  V+   LQ S +++   L+   QE EAL+ E  S   Q  
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957

Query: 1816 --------LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQT 1867
                    LQ A GK+ A         L   +   S +     +          + +L+ 
Sbjct: 1958 AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017

Query: 1868 MVQNTKAELTHS----REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQK 1923
             ++  + E+       +E V+QL+  L  + ++        +  E+E+L  K    + Q+
Sbjct: 2018 ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE------LRHQQEREQLLEKSLAQRVQE 2071

Query: 1924 EQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWD 1983
                  + + Q    E+E+  +H     L+    + +++++E++  +        PH+  
Sbjct: 2072 NMIQEKQNLGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130

Query: 1984 LQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENR---------TSETNTPQGN 2034
               +++Q+  +   E  LQ + + LQA  + Q    E+E R          ++T     +
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQA-ALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189

Query: 2035 QEQLVTVMEERMIE-------VEQKLKLVKRLLQEKVNQLKEQVSLPG 2075
             +++   ++  ++E       ++ +L+L +R L+      KE++  PG
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALE------KERLHSPG 2231



 Score =  139 bits (351), Expect = 2e-32
 Identities = 327/1562 (20%), Positives = 642/1562 (41%), Gaps = 257/1562 (16%)

Query: 313  VERILDTWQEEGIENSQEILKALDF----SLDGNINLTE-------LTLALENELLVTKN 361
            V ++ + W++E   + QE+ KAL+      ++  + L E       +    E E    ++
Sbjct: 855  VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914

Query: 362  SIHQAALASFKAEIRHLLERVDQVVRE-------KEKLRSDLDKAEKLK-----SLMASE 409
            ++ Q  L + K  +  LLE + Q  +E        E+LR D+ K +KLK      ++ ++
Sbjct: 915  ALCQMQLETEKERV-SLLETLLQTQKELADASQQLERLRQDM-KVQKLKEQETTGILQTQ 972

Query: 410  VDDHHAAIE---RRNEYNLRKLDEEYKERI---AALKNELRKEREQILQQAGKQRLELEQ 463
            + +    ++   R++  +L  L EE    +     L+ ++   + Q++ Q   QRL +EQ
Sbjct: 973  LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL-VEQ 1031

Query: 464  EI-EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENV---LA 519
            E+ EK +  + Y R +  L  +E + L   L+E  ++L   +   +  Q+ L  +   + 
Sbjct: 1032 EVQEKLRETQEYNRIQKELE-REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQ 1090

Query: 520  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD-------ELQSELEEYRAQGR 572
            E  G+    SA+  L  + + +   ++  Q   L ++++       +L++ L    A+  
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150

Query: 573  VLRLPLKNS------------PSEEVEANS------------------------------ 590
             L+L L+++            P  + +A +                              
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210

Query: 591  ---GGIEPEHGLGSE--ECNPLNMSIEAELVIEQM--------KEQHHRDICCLRLELED 637
                G+EP+        +  PL  ++ AE V   +        K Q  RD+      L D
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV------LRD 1264

Query: 638  KVRHYEKQLDETVVSCKKAQ---------------ENMKQRHENETHTLEKQISDLKNEI 682
            +V+  E++L +T    +K+Q               +  K + E + ++LE ++ +L   +
Sbjct: 1265 QVQKLEERLTDT--EAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322

Query: 683  A--------------ELQGQAAVLKEAHHEATCRHE-------EEKKQLQVK--LEEEKT 719
            A              E QG+  +L+ A    T + E       E + Q      LEE+  
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382

Query: 720  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
              +  L+L++E E+++   +AQA  E+    +      +E +  LTQ L +  +E  T  
Sbjct: 1383 TARSALKLKNE-EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441

Query: 780  VEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 838
             +   LEK+ E++K  LE    +L++  ++++ +      Q + Q    C+ V E    A
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ------QEQIQELEKCRSVLEHLPMA 1495

Query: 839  LQSLEGR---YRQELKDLQEQQREEKSQWEFEKDELTQ--ECAEAQELLKETLKREKTTS 893
            +Q  E +    R+++++L++ +  +++  E +  EL +  +  E+Q    + LK++  T 
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555

Query: 894  LVLTQE-------REMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 946
              L  E        E  +K  KE       +R  L     DL   S+  Q+  S QI +L
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA-QSSQIHDL 1614

Query: 947  KSSH---KRELRER-EEVLCQAGASEQLASQRLERLEMEHDQERQEMM------------ 990
            +S      REL+ER +EV  Q    E+L  Q+ E L  + ++  QE+M            
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIEELQRQK-EHLTQDLERRDQELMLQKERIQVLEDQ 1673

Query: 991  ----SKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSGCQVI 1045
                +K+L  E++ +      +R R E++T+   +Q + +E +  + +    L+    ++
Sbjct: 1674 RTRQTKILE-EDLEQIKLSLRERGR-ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731

Query: 1046 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL- 1104
             ++E E +     + + ++L ++    L  L R   +      +   EI  LQQ+LQ+  
Sbjct: 1732 RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791

Query: 1105 EPGLVMSSCLDEPATEFFGNTAEQTEPF--LQQNRTKQVEGVTRR------HVLSDLEDD 1156
            E G +    L     E     A++ +    LQQ + +Q +G   R       +   LE  
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQ-QQAQGQEERVKEKADALQGALEQA 1850

Query: 1157 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET----RTESWELKNQISQLQEQ 1212
             +      G     +++ +  E E +VEG   ++  EE     R ES E +  +  LQ+Q
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEG-RRVQALEEVLGDLRAESREQEKALLALQQQ 1909

Query: 1213 LMMLCADCDRASEKKQDLLFD-----VSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1267
                CA+  +  E +   L D      +VLK++ + LE +   S   +   E      + 
Sbjct: 1910 ----CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965

Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSY-----DEVKI 1322
            LQE L     +   AL+  ++   E   L   L+      +  L   +++     + ++I
Sbjct: 1966 LQEAL----GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 1323 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLE-----NLEIEPDGNILQLNQTL- 1376
            +  E+    LR Q  +++LQ+++ QR +    +   E     +L      N++Q  Q L 
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081

Query: 1377 -EECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH--QERPRVQN 1433
             E     +R +H  + E            QL    K  EI  L  T Q +  +  P    
Sbjct: 2082 QEREEEEIRGLHQSVRE-----------LQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130

Query: 1434 QVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKER---VTILVKQKDVLSH 1490
               +EE +  L   +   Q +    +  L +T+ +E+  + K +   +++   +  V S 
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190

Query: 1491 GEKEEELKAMMHDLQITCSEMQQKVELLR--YESEKLQQENSILRNEITTLNEEDSISNL 1548
             E    L+A + +       +Q ++EL R   E E+L    +    E+ +  E+     +
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ----GV 2246

Query: 1549 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1608
            +LG ++G + E          E  + ++ +E+L++ ++ L+I   +L   N +L     Q
Sbjct: 2247 QLGEVSGVEAE----PSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302

Query: 1609 NQEKLQELNQRLTEMLCQKEKEPGN-SALEEREQEKFNLKEELERCKVQSSTLVSSLEAE 1667
             + + ++L +           E    +A    +Q+    K    +C  +    V  L+A+
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQ 2362

Query: 1668 LS 1669
            L+
Sbjct: 2363 LT 2364



 Score =  104 bits (259), Expect = 1e-21
 Identities = 174/837 (20%), Positives = 364/837 (43%), Gaps = 101/837 (12%)

Query: 1281 EALENNKELTAEVFRLQDELKKME---EVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1337
            EA E ++EL     + Q +L+K E    VTE    L +S  +    NE+   ++  L+  
Sbjct: 259  EAHERSQELIQ--LKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALRET 312

Query: 1338 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1397
            +E L+ +  +  +    EASL     E   ++ Q+ + + + +  V    ++ +    EN
Sbjct: 313  VEILETNHTELME---HEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHEN 367

Query: 1398 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATI 1457
              LE ++ +  +    +       +++   R R   Q + +    L G Q+        +
Sbjct: 368  S-LELDSSIFSQFDYQDADKALTLVRSVLTRRR---QAVQDLRQQLAGCQE-------AV 416

Query: 1458 AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVEL 1517
              L+ +  + +E  + L++R+  L  ++D L+             DLQ     + ++ EL
Sbjct: 417  NLLQQQHDQWEEEGKALRQRLQKLTGERDTLA---------GQTVDLQGEVDSLSKEREL 467

Query: 1518 LRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKM 1577
            L+   E+L+Q+  +L  E   L   +    L+  +  G +EE  ++     +E   +Q+M
Sbjct: 468  LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527

Query: 1578 VENLK----KQISEL----------KIKNQQLDLENTELSQKNSQNQEKLQEL----NQR 1619
            +  L+    + +SEL           ++ + L  E TE++   ++ ++ + EL    N  
Sbjct: 528  LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587

Query: 1620 LTEMLCQKEKEPGNSALEER-EQEKFNLKEELERCKVQSSTLVSSLEA----------EL 1668
             TE+   +      SAL E    +K  L ++L + + ++ ++ S +EA          +L
Sbjct: 588  KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647

Query: 1669 SEVKIQTHIVQQENHLLKDELEKMKQ--LHRCPDLSDFQQKISSVLSYNEKLLKEKEALS 1726
            +E + +   + ++N  L+ +L+K ++       DL D Q++   +    +K L E     
Sbjct: 648  AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----QKKLSESRHQQ 703

Query: 1727 EELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN 1785
            E   + +++L  ++   E  +A   QE+++   + A+L+ +L A +   Q+L + +Q ++
Sbjct: 704  EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763

Query: 1786 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG---------KSWAPEIATHPSGLH 1836
                 ++S L   QQ+   ++     L  Q+Q             +    E+ T  S   
Sbjct: 764  SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823

Query: 1837 NQQ----KRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1892
             ++    ++L+  + +     EQQ    E E  Q   +  K    H +E  + LES  L 
Sbjct: 824  QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES--LE 881

Query: 1893 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1952
            + +  L        TE E +  +RE     +E++ A   + QM  LE E E + L  E L
Sbjct: 882  REKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALCQM-QLETEKERVSL-LETL 934

Query: 1953 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2012
             + Q +L +   +++ LR             +Q L++Q    + + Q  + QR+L +A R
Sbjct: 935  LQTQKELADASQQLERLRQD---------MKVQKLKEQETTGILQTQLQEAQRELKEAAR 985

Query: 2013 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2069
             ++     L+  +S     + + ++ V  ++ +++  +   +LV++ +QEK+ + +E
Sbjct: 986  QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042



 Score = 40.0 bits (92), Expect = 0.024
 Identities = 105/550 (19%), Positives = 212/550 (38%), Gaps = 77/550 (14%)

Query: 1556 SQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQE 1615
            +Q   W+K +  ++       +V  L+ ++ + +   Q+L+           Q  E ++E
Sbjct: 34   NQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEE 93

Query: 1616 LNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEA--------- 1666
             N  L E+L + E+E      E   +    L+  +E+  V +  L   +E          
Sbjct: 94   PN--LDELLVRLEEE--QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR 149

Query: 1667 -ELSEVKIQTHIVQQ-ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEA 1724
             EL   + Q  + Q+     LK E  ++  L R  ++  F++    + S  ++ L E +A
Sbjct: 150  DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWR--EVVTFRRHFLEMKSATDRDLMELKA 207

Query: 1725 ----LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDT 1780
                LS  L +C  +L         +    +E            +QL+    K Q LE  
Sbjct: 208  EHVRLSGSLLTCCLRLT--------VGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKE 259

Query: 1781 VQNVNLQMSRMKS--DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA------------- 1825
                + ++ ++KS  DL   + +    +   +    Q QN   +                
Sbjct: 260  AHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETN 319

Query: 1826 -PEIATHPSGL--HNQQKRLSWDKLDHLMNEEQQLLWQENERL-QTMVQNTKAELTHS-- 1879
              E+  H + L  + Q+++LS   L  ++ +  Q++ +E + + Q        EL  S  
Sbjct: 320  HTELMEHEASLSRNAQEEKLS---LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376

Query: 1880 -------REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLS-LKRECDQFQKEQSPANRK 1931
                    +K   L  ++L + ++ +          QE ++ L+++ DQ+++E       
Sbjct: 377  SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEG------ 430

Query: 1932 VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQA 1991
                 +L Q L+ +  E + L  + V L  ++  +   R     +       L++L+Q+A
Sbjct: 431  ----KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEA 486

Query: 1992 CPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQ 2051
              +      LQLQ    Q ++  Q  QEEL     E    Q    +++  +E +  E   
Sbjct: 487  WRLRRVNVELQLQGDSAQGQKEEQ--QEELHLAVRERERLQ----EMLMGLEAKQSESLS 540

Query: 2052 KLKLVKRLLQ 2061
            +L  ++  L+
Sbjct: 541  ELITLREALE 550


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  208 bits (530), Expect = 4e-53
 Identities = 383/1789 (21%), Positives = 736/1789 (41%), Gaps = 204/1789 (11%)

Query: 347  ELTLALENELLVTKNSIHQAALASFKAEIRHLL-----------ERVDQVVREKEKLRSD 395
            E  L  E E L  +    Q  L   + ++R L            E+  Q +R +++LR  
Sbjct: 250  ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309

Query: 396  LDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAG 455
             ++  + +     E  +     E R E  LR+  EE +E+      +LR+E+E+  ++  
Sbjct: 310  QEEERREQQEERREQQERREQQEERREQQLRREQEERREQ------QLRREQEEERREQQ 363

Query: 456  KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLE 515
             +R + E+  E+    E  +R    L  ++  R E + L   ++L   + L  + Q   E
Sbjct: 364  LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQQLRREQQLRRE 422

Query: 516  NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE----LQSELEEYRAQG 571
              L  +             QEE   + ++E ER+ + L+ + +E    L+ E E  R + 
Sbjct: 423  QQLRRE-------------QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469

Query: 572  RVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ-MKEQHHRDICC 630
               +  LK    EE       +E E     +E     +  E E   EQ +K Q   +   
Sbjct: 470  ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529

Query: 631  LRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAA 690
             RL  E ++R  +++           +E + +R E +    E++   LK E         
Sbjct: 530  QRLRSEQQLRREQEE----------RREQLLKREEEKRLEQERREQRLKRE--------- 570

Query: 691  VLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKL------RLQHEMELKARLTQAQASF 744
              +E   +   + EEE++Q ++K E+E+  L+++L      RL+ E   + RL + +   
Sbjct: 571  --QEERRDQLLKREEERRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPEE 627

Query: 745  EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQREL-Q 803
            ER ++ L+S    E + + L +E ++  +++L    E+  LE+   R+   E+ ++EL +
Sbjct: 628  ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 804  EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ 863
            E +E+       R  + + Q +S+      +  S  +  EG+ R++ ++ + ++RE + Q
Sbjct: 688  EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747

Query: 864  WEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQ 923
            W+ E+    Q+  E Q       +R+ T      Q  E  E+  ++ L++    R+Q  +
Sbjct: 748  WQEEERAHRQQQEEEQ-------RRDFTWQ---WQAEEKSERG-RQRLSARPPLREQRER 796

Query: 924  DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL-ASQRLERLEMEH 982
             L         Q+ L  +   E K   +R+ RERE+ L      EQL   +R ++L+ E 
Sbjct: 797  QLRAEERQQREQRFLPEE---EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853

Query: 983  D---QERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1039
            D   ++++   S+    +   +   E   + R         LQ ++++ QQ      +LQ
Sbjct: 854  DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ------LLQ 907

Query: 1040 SGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQ 1099
               + +  EE E        +Q  Q  EE       LQ+  EQ ++E         R ++
Sbjct: 908  EEEEELQREERE---KRRRQEQERQYREEE-----QLQQEEEQLLRE--------EREKR 951

Query: 1100 RLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVR 1159
            R Q+ E        L +   +  G   E+     ++ + ++ E + +       E+ E R
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 1160 DLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
                      ++ E++ EE +   E   +    E  R   +  + ++ Q +EQL+    +
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEEEQLLGEERE 1069

Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM---- 1275
              R  E ++    +  + +++ ++L   PE   + +   E   RE + LQ+E   +    
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE--RERQCREEEELQQEEEQLLREE 1127

Query: 1276 -ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
             E R  + LE       EV + +++L + E        LE+ Y E +   +E   L+   
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 1335 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLN-QTLEECVPRVRSVHHVIEEC 1393
            Q K  + +E   +  +    +   +    E   + L+   +  +E   R   V+    E 
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247

Query: 1394 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQ---------NQVILEENT 1441
            +Q  Q LE ++QL ++    ++  L G  Q     QER R Q          Q+  EE  
Sbjct: 1248 EQFRQ-LE-DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305

Query: 1442 TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1501
                   K  + +  + E   EK + QE  RK +E   +L ++        +E+ L+   
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER--------EEQPLRRQE 1357

Query: 1502 HDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--LNEEDSISNLKLGTLNGSQEE 1559
             D +    E++ + +  ++    L++E  + R E     L EE      +L      Q+ 
Sbjct: 1358 RDRKFREEELRHQEQGRKF----LEEEQRLRRQERERKFLKEEQ-----QLRCQEREQQL 1408

Query: 1560 MWQKTETVKQENAAVQKMVENLKKQISELKIKNQQ-----LDLENTELSQKNSQNQEKLQ 1614
               +    ++E   + +   + K +  E +++ Q+     L+ E     +++ + +E+ Q
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 1615 ELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQ 1674
             L +R  + L ++E++     LEE +Q +   ++E +R   +        E +  E + Q
Sbjct: 1469 LLQEREEQQLHRQERD--RKFLEEEQQLR---RQERDRKFREQELRSQEPERKFLEEEQQ 1523

Query: 1675 THIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD 1734
             H  Q++   L++E +  +Q        D  +K        E+L +E+E   E+  S  +
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE----EEQLRQERE---EQQLSRQE 1576

Query: 1735 KLAKSSLLEHRIATMKQEQKSW--EHQSASLKSQLVASQEKVQNLEDTVQ----NVNLQM 1788
            +  K  L E ++   +QE+K    E Q    + Q    QE+ +   +  Q        Q+
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636

Query: 1789 SRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1848
             R + D +  ++E +  +QE     +QL++   + +  E      G   Q +R   D+  
Sbjct: 1637 HRQERDRKFLEEEPQLRRQE---REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-- 1691

Query: 1849 HLMNEEQQLLWQENER--LQTMVQNTKAELT---HSREKVRQ-LESNLLPKHQKHLNPSG 1902
                EEQQL  QE ER  LQ   Q  + EL       E++RQ  E   L + +++     
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY----- 1746

Query: 1903 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1962
                 E+E+L  +RE  Q ++++   +RK  +   L QE E   L ++   +K  + ++ 
Sbjct: 1747 -RKILEEEQLRPEREEQQLRRQE--RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803

Query: 1963 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELE 2022
              E +  +         + W+ + LQ            L+ Q Q L+ ER  Q+  E  E
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQ------------LEEQEQRLRQERDRQYRAE--E 1849

Query: 2023 NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
               ++  + +  QE      ++R  E E+KL+      Q+K  Q   QV
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898



 Score =  203 bits (517), Expect = 1e-51
 Identities = 394/1846 (21%), Positives = 762/1846 (41%), Gaps = 241/1846 (13%)

Query: 331  ILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKE 390
            IL+ LD   +G ++  E  L            I + A A + A        + Q     E
Sbjct: 57   ILELLDLDSNGRVDFNEFLLF-----------IFKVAQACYYA--------LGQATGLDE 97

Query: 391  KLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI 450
            + R+  D  E L      E D      +RR E   R+L+EE  +R    + E  +E  + 
Sbjct: 98   EKRARCDGKESLLQDRRQEED------QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151

Query: 451  LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN-----AEKLAEYEN 505
             +Q+ KQ   LEQ  ++ + +E   R R     +E  R E E L++      E+  + E 
Sbjct: 152  EEQSEKQE-RLEQR-DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209

Query: 506  LTNKLQRNLENVLAEKFGDLDPSSAEFFLQEE-------RLTQMRNEYERQCRVLQDQVD 558
            L  +    L     E+         +   QEE       R T +R E E+    LQ++  
Sbjct: 210  LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK----LQEEEP 265

Query: 559  ELQSELEEYRAQGRVL-RLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVI 617
            + Q EL+E   Q R L R  L+    EE +        +     +E        E     
Sbjct: 266  QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325

Query: 618  EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD 677
            E+ ++Q  R    LR E E++    E+QL       ++ Q+  +++ E       ++   
Sbjct: 326  ERREQQEERREQQLRREQEER---REQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 678  LKNEIAELQGQAAVLKE--AHHEATCRHEEE-KKQLQVKLEEEKTHLQEKLRLQHEMELK 734
            L+ E  +L+ +  + +E     E   R E++ +++ Q++ E++    QE+ R + + E +
Sbjct: 383  LRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 735  ARLTQAQASFEREREGLQSSAWT-----EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEE 789
             R  + +   E  R+ L+    T     E + + L ++ E+  +E+   L E+   E++E
Sbjct: 442  RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501

Query: 790  LRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQE 849
             R++ L + Q E +E R K + E  R    ++ + +S+ Q   E+ E   Q L+   R+E
Sbjct: 502  RREQQLRREQEERREQRLKRQEEEER----LQQRLRSEQQLRREQEERREQLLK---REE 554

Query: 850  LKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKE 909
             K L++++RE++ + E +++   Q     +E  ++ LKRE+   L    +RE +E+  +E
Sbjct: 555  EKRLEQERREQRLKRE-QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613

Query: 910  HLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQ 969
                  ++R++  ++       SE Q+     Q+       +RE +ER E   +    E+
Sbjct: 614  ERREQRLKREEPEEERRQQLLKSEEQEERRQQQL-------RREQQERREQRLKREEEEE 666

Query: 970  LASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1029
               QRL+R   EH++ER+E        E   +       + + ++ +E    QSK+    
Sbjct: 667  RLEQRLKR---EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723

Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK 1089
            +        Q G +   E+E +     S LQ  E+            +RAH Q  +E  +
Sbjct: 724  RK-------QEGQRRRQEQEEKRRRRESELQWQEE------------ERAHRQQQEEEQR 764

Query: 1090 -------MATEIS-RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEP-FLQQNRTKQ 1140
                    A E S R +QRL    P        ++   +      +Q E  FL +   K+
Sbjct: 765  RDFTWQWQAEEKSERGRQRLSARPP------LREQRERQLRAEERQQREQRFLPEEEEKE 818

Query: 1141 VEGVTRRH---VLSDLEDDEVRDLGSTGTSSVQRQE--VKIEESEASVEGFSELENSEET 1195
                 RR     L  LE++E           +QR+E   +++E E  ++   E   S+E 
Sbjct: 819  QRRRQRREREKELQFLEEEE----------QLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868

Query: 1196 RTES---WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASP 1252
            R +    W+L+ +  + +  L    A  ++  +++Q L  +   L+++ +   R  E   
Sbjct: 869  RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928

Query: 1253 KYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLS 1312
            +Y+   +    E   L+EE    E R  +  E       ++ + +++L   E        
Sbjct: 929  QYREEEQLQQEEEQLLREE---REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985

Query: 1313 LEKSY-DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENL-EIEPDGNIL 1370
             EK Y +E +++ EE    +LR + +  + QE          WE       E++ +   L
Sbjct: 986  REKKYREEEELQQEEEQ--LLREEREKRRRQE----------WERQYRKKDELQQEEEQL 1033

Query: 1371 QLNQTLEECVPRVRSVHHVIEECKQENQYLEG------NTQLLEKVKAHEIAWLHGTIQT 1424
               +  +  +      +   EE +QE + L G        Q LE+    E        Q 
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093

Query: 1425 HQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ 1484
             +E P  + +   +E       +++  Q +  +   E EK + QEL R+ +E   +  ++
Sbjct: 1094 LREEPEKRRR---QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150

Query: 1485 KDVLSHGEKEEELKAMMHDLQITCSE----MQQKVELLRYESEKLQQENSILRNEITTL- 1539
            + +L    +EE  K    +L+    E     Q++ +LLR E EK +QE      E   L 
Sbjct: 1151 EQLL----REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206

Query: 1540 --------NEEDSISNLKLG--------------TLNGSQEEMWQKTETVKQENAAVQKM 1577
                     +ED  S+LK                   G + E +++ E  +  +   Q+ 
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD 1266

Query: 1578 VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE 1637
            +++L   + E + ++++ +    +   ++   +E+L+   Q+  +   +K +E      E
Sbjct: 1267 LQHL---LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323

Query: 1638 EREQE--------KFNLKEELERCKVQSSTLVSSLEAELSEVKIQ-----THIVQQENHL 1684
            ERE++        KF  +E+L + + +        + +  E +++        +++E  L
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383

Query: 1685 LKDELE----KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
             + E E    K +Q  RC    + +Q++      + K  +E++ LS +     ++  K  
Sbjct: 1384 RRQERERKFLKEEQQLRC---QEREQQLRQ--DRDRKFREEEQQLSRQ-----ERDRKFR 1433

Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800
              E ++   ++E+K  E +    + +    +E+ Q L++  +    Q+ R + D +  ++
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ---QLHRQERDRKFLEE 1490

Query: 1801 EKEALKQEVMSLHKQLQNAGGKSWAPE--IATHPSGLHNQQKRLSWDKLDHLMNEEQQLL 1858
            E++  +QE     ++ +    +S  PE         LH QQ++  +      + EEQQL 
Sbjct: 1491 EQQLRRQE---RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF------LQEEQQLR 1541

Query: 1859 WQENERLQTMVQNTK-AELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEK------ 1911
             QE  + +   ++ K  E    R++  + + +   + +K       +   EQE+      
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601

Query: 1912 LSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              L+R+  Q Q  Q   +RK  +   L QE E   L  +   +K ++ + QL   +  + 
Sbjct: 1602 QQLRRQEGQQQLRQE-RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQ----FLQLQRQLLQAERINQHLQEELENRTSE 2027
                       + QLLQ+     + R++    F + ++QL + ER  + LQEE + R  E
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720

Query: 2028 TNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                   +EQL    E+  +  +++ +  K L +E++   +E+  L
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYR--KILEEEQLRPEREEQQL 1764



 Score =  112 bits (279), Expect = 5e-24
 Identities = 152/666 (22%), Positives = 284/666 (42%), Gaps = 66/666 (9%)

Query: 376  RHLLERVDQVVREKEKLRSDLD-KAEKLKSLMASEVDDHHAAIERRNEYNLRK-LDEEYK 433
            RH  E  +Q+ RE++K     D K+++ K L+  E ++     E   ++   + L +E +
Sbjct: 1291 RHFPEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349

Query: 434  ERIAALKNELRKEREQIL--QQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLEN 491
            E+    +   RK RE+ L  Q+ G++ LE EQ + + + E  ++++   L  +E    E 
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER---EQ 1406

Query: 492  ELLENAE-KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 550
            +L ++ + K  E E   ++ +R+ +    E+         +F  +E++L Q R+   R+ 
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466

Query: 551  RVLQDQVDELQSELEE----YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 606
              L  + +E Q   +E    +  + + LR   ++    E E  S   EPE     EE   
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ--EPERKFLEEE--- 1521

Query: 607  LNMSIEAELVIEQM-KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
                       +Q+ ++Q  R      L+ E ++R  E+         +K +E  + R E
Sbjct: 1522 -----------QQLHRQQRQRKF----LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566

Query: 666  NETHTLEKQISDLKNEIAE--LQGQAAVLKEAHHEATCRHEEEKKQLQV----KLEEEKT 719
             E   L +Q  D K  + E  ++ Q    K    E   R +E ++QL+     K  E++ 
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626

Query: 720  HLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTS 778
             LQE+   Q H  E   +  + +    R+    Q     + K R   Q L++  ++QL  
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686

Query: 779  LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESA 838
                    +EE +    E+ ++ LQE ++    E  R+  + E   Q   Q+   R E  
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746

Query: 839  LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 898
             + LE    +  ++ Q+ +R+E+ +   E+++L QE  E Q+L  +   R+      L Q
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE-REEQQLRSQESDRKFREEEQLRQ 1805

Query: 899  EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRERE 958
            ER                E QQL     D +   E +Q  L +Q   L+    R+ R  E
Sbjct: 1806 ER----------------EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849

Query: 959  EVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEI 1018
            +      A+++ + +  + L  E +Q+R++   + L  E+I +   +  + +R     EI
Sbjct: 1850 QF-----ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR---QQKEEQRHRQVGEI 1901

Query: 1019 SRLQSK 1024
               + K
Sbjct: 1902 KSQEGK 1907


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  206 bits (524), Expect = 2e-52
 Identities = 371/1710 (21%), Positives = 712/1710 (41%), Gaps = 261/1710 (15%)

Query: 393  RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 445
            + DL K  K + ++  +       +E+   E   + + E   + I AL   L      + 
Sbjct: 27   KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86

Query: 446  EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 501
            E EQ      K+ ++++QE+E + T+       L  S    +KE   L+NEL+    K +
Sbjct: 87   ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146

Query: 502  EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 558
            E + NL  +L+   N +  L+E+    + S       +E + ++R  +E Q   LQ Q+D
Sbjct: 147  EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206

Query: 559  ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 618
                E +E   Q       L+N     +EANS   +               S++ EL+  
Sbjct: 207  ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242

Query: 619  QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 671
            Q+K  H  ++  L  ++E   + +E ++       +  V  C+ +++N+++++E E   L
Sbjct: 243  QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302

Query: 672  EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 729
             K  S+    N+I  +  Q     E       +H E+  +   +LE + + L++++   +
Sbjct: 303  RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359

Query: 730  EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 787
             ++LK  +     +  F  ERE L      E K+  L        +E+   ++EK   E 
Sbjct: 360  NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408

Query: 788  EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 844
              L K+    +E+H RE+Q  +E+ + E     S++   F SD +K        +Q L  
Sbjct: 409  AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462

Query: 845  RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 898
              +++ ++LQ++++E    +E  ++  E+ Q E  E+   +    E++K+++ + +   Q
Sbjct: 463  --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520

Query: 899  EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 956
            ++          L +   E+  LL+ +  L+  +E    LLS Q L  EL+++ K  L+E
Sbjct: 521  QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1012
            +  V   + +      + LE       +E+ + ++KL      M+N HK  CE  +R   
Sbjct: 567  KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625

Query: 1013 EMSTEISR------------------LQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGD 1053
            E+  ++ +                  L+  +KE  Q    L  L    +V+ E+ EV   
Sbjct: 626  ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685

Query: 1054 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL--EPGLVMS 1111
               SL ++  +L  E   +   L+    Q  KE+V +   I++L+++LQ +  E   +  
Sbjct: 686  EVKSLYEENNKLSSEKKQLSRDLEVFLSQ--KEDVILKEHITQLEKKLQLMVEEQDNLNK 743

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
               +E   + F  T  Q   FL++  ++  E           E D V  L + G S  + 
Sbjct: 744  LLENEQVQKLFVKT--QLYGFLKEMGSEVSE--------DSEEKDVVNVLQAVGESLAKI 793

Query: 1172 QEVKIEESEASVEGFSELEN-----SEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1226
             E K   +    E   ELE       EE+  +  ELK+ +   +++ ++L  + +    +
Sbjct: 794  NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853

Query: 1227 KQDLLFDVSVLKKK-----------LKMLERIPEASPKYKLLYEDVS---RENDCLQEEL 1272
            K+ L  D+  +K             L  +E + +   K ++  E      +E++ L+  L
Sbjct: 854  KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913

Query: 1273 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIEN-------- 1324
               E R         +  AE+  L+D L K   V    LS  K  +E KIEN        
Sbjct: 914  EQKELR---------DRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEKECKEK 963

Query: 1325 -EELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRV 1383
             E++N + L      ++L  S   R +    +  LE+L  E D    QL+ ++ + +   
Sbjct: 964  EEKINKIKLVAVKAKKELDSS---RKETQTVKEELESLRSEKD----QLSASMRDLIQGA 1016

Query: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI------- 1436
             S  +++ E +++++ L+     +EK +A+        +        +Q + I       
Sbjct: 1017 ESYKNLLLEYEKQSEQLD-----VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071

Query: 1437 ------LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSH 1490
                  L+ N  LL  Q    Q    + + ELE  KLQ+  +K+KE  T + + +++   
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQKIKEHATTVNELEELQVQ 1130

Query: 1491 GEKE-EELKAMMHDLQITCSEMQQ----KVELLRYE--SEKLQQENSILRNEITTLNEED 1543
             +KE ++L+  M +L++   + QQ     +E+  YE   ++L Q+ +   N+I  L +E 
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190

Query: 1544 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1603
             I   K  TL      +    +  +++N  +++++   KK++++ K       +    L 
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK 1250

Query: 1604 QKNSQNQEKLQELNQRLTEMLCQKEK---------EPGNSALEEREQEKFNLKEELERCK 1654
             +   +Q++++    +L E+  +K K         E     L   +Q    L+EE    K
Sbjct: 1251 GELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAK 1310

Query: 1655 VQSSTLVSSLEAELSEVKIQTHIVQQENHLL--------KDELEKMKQL--HRCPDLSDF 1704
             + +T+ S  E E  +V++   + QQ+N  +        K E E ++ L       L D 
Sbjct: 1311 AEQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS 1368

Query: 1705 QQKISSVLSYNEKLLKEKEALSEELNSCV-DKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
            Q  +   +S  + L  E + L E  N  + + ++K + L  ++ +++ E    + +    
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQT 1428

Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
             SQL +  E ++N      +   Q+  ++ + R T    E L+Q++  +  QL     + 
Sbjct: 1429 VSQLTSQNEVLRN------SFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEP 1479

Query: 1824 WAPEIATHPSGLHNQQKRLSWD--KLD-HLMNEEQQLLWQENERLQTMVQNTKAELTHSR 1880
                  +    L N ++R + D   LD H +  E      E E ++T    T  E   S 
Sbjct: 1480 TTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE------EGEGMET----TDTESVSSA 1529

Query: 1881 EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQ 1940
                Q    LL   +  L P        +E+L  K          S   +    +N L +
Sbjct: 1530 STYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK---------LSSTTKSADHLNGLLR 1580

Query: 1941 ELE---TIHLENEGLKKKQVKLDEQLMEMQ 1967
            E E    I +E   L K +++  E+  E +
Sbjct: 1581 ETEATNAILMEQIKLLKSEIRRLERNQERE 1610



 Score =  144 bits (363), Expect = 9e-34
 Identities = 279/1388 (20%), Positives = 589/1388 (42%), Gaps = 238/1388 (17%)

Query: 766  QELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR----------------EKM 809
            ++L +F ++Q+  L++K      EL KE+ E   + + EG                 EK 
Sbjct: 28   EDLIKFAKKQMM-LIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86

Query: 810  ETE-----CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQW 864
            ETE       +   +++ + +    K+ +     L+     Y +E+++L+ +    +S++
Sbjct: 87   ETEQQCLSLKKENIKMKQEVEDSVTKMGD-AHKELEQSHINYVKEIENLKNELMAVRSKY 145

Query: 865  EFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKT----------YKEHL 911
              +K  L ++  EA      L E LK +  +   + + +E +EK            ++ L
Sbjct: 146  SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQL 205

Query: 912  NSMVVERQQLLQDLEDL--RNVSETQQSL--LSDQILELKSSHKRELREREEVLCQAGAS 967
            ++   E+++ +  L+++   N    Q+++  L +++L+LK+ H+ E++E   ++CQ  AS
Sbjct: 206  DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKE---LMCQIEAS 262

Query: 968  EQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE 1027
             +           EH+ E    ++KL  ++      CE +++   +      + + +++ 
Sbjct: 263  AK-----------EHEAE----INKLNELKENLVKQCEASEKNIQK------KYECELEN 301

Query: 1028 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1087
            +++ATS  +     C ++ +E    +  ++      + ++   D L  L+  H     E 
Sbjct: 302  LRKATSNANQDNQICSILLQENTFVEQVVN------EKVKHLEDTLKELESQHSILKDEV 355

Query: 1088 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1147
              M     +L+   Q ++              EFF    +      +    K+ +G    
Sbjct: 356  TYMNNLKLKLEMDAQHIKD-------------EFFHEREDLEFKINELLLAKEEQGCVIE 402

Query: 1148 HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQIS 1207
             + S+L     +   +    + + Q +K E+ +  +   +E   S+  + E   L  +I 
Sbjct: 403  KLKSELAGLNKQFCYTVEQHNREVQSLK-EQHQKEISELNETFLSDSEK-EKLTLMFEIQ 460

Query: 1208 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-RIPEASPKYKLLYEDVSREND 1266
             L+EQ       C+   ++KQ+ + +   L++ +++L+  + E++ K    +E + ++  
Sbjct: 461  GLKEQ-------CENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513

Query: 1267 C----LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKI 1322
                 LQ++LR   T  D  LE    L  E  +L  + + + E+  T  +L++      +
Sbjct: 514  SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573

Query: 1323 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPR 1382
               + + ++  L+GKI  L E                    E D  I +L  + EE    
Sbjct: 574  SLSQRDTMLKELEGKINSLTE--------------------EKDDFINKLKNSHEE---- 609

Query: 1383 VRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI--LEEN 1440
               + +  ++C++E + +    +L +KV+         TIQ + E  +  N++   LEE 
Sbjct: 610  ---MDNFHKKCEREERLI---LELGKKVEQ--------TIQYNSELEQKVNELTGGLEE- 654

Query: 1441 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500
                           T+ E +    KL++L  ++K    +L + K+VLS      E+K++
Sbjct: 655  ---------------TLKEKDQNDQKLEKLMVQMK----VLSEDKEVLS-----AEVKSL 690

Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE-----DSISNLKLGTLNG 1555
              +     SE +Q    L  E    Q+E+ IL+  IT L ++     +   NL     N 
Sbjct: 691  YEENNKLSSEKKQLSRDL--EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENE 748

Query: 1556 SQEEMWQKTET---VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1612
              ++++ KT+    +K+  + V +  E  K  ++ L+   + L   N E      Q  EK
Sbjct: 749  QVQKLFVKTQLYGFLKEMGSEVSEDSEE-KDVVNVLQAVGESLAKINEEKCNLAFQRDEK 807

Query: 1613 LQELNQRLTEMLCQKEK-----EPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAE 1667
            + EL +   E+ C +E+     E   S L + EQEK  L++ELE  ++QS     +L+++
Sbjct: 808  VLELEK---EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EIQSEK--EALQSD 860

Query: 1668 LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSE 1727
            L E+K      + EN  L  ++E++ Q     ++ + ++K       N K L E++ L +
Sbjct: 861  LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD 920

Query: 1728 ---ELNSCVDKLAKS-SLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQN 1783
               EL    D LAKS S+    ++++K+ ++  E+    L+ +    +EK+  ++     
Sbjct: 921  RRAELILLKDSLAKSPSVKNDPLSSVKELEEKIEN----LEKECKEKEEKINKIKLVAVK 976

Query: 1784 VNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA--GGKSWAPEIATHPSGLHNQQKR 1841
               ++   + + +  ++E E+L+ E   L   +++   G +S+   +  +     ++Q  
Sbjct: 977  AKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK--QSEQLD 1034

Query: 1842 LSWDKLDHLMNEEQQLLWQ-ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1900
            +  ++ ++  +  + L  Q  N  LQ    N+  E   +R +  Q  + LL      +  
Sbjct: 1035 VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR 1094

Query: 1901 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1960
            +  M   E E        ++ QKEQ     K+ +  +   ELE + ++   L+K++ +L 
Sbjct: 1095 AKAMVDKELE-------AEKLQKEQ-----KIKEHATTVNELEELQVQ---LQKEKKQLQ 1139

Query: 1961 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE 2020
            + + E++ ++  A              QQ     +    + +L ++L Q      +  E+
Sbjct: 1140 KTMQELELVKKDA--------------QQTTLMNMEIADYERLMKELNQKLTNKNNKIED 1185

Query: 2021 LENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL-----------QEKVNQLKE 2069
            LE         Q   ++ +T ++  + + E+K   +K+LL           Q + + L  
Sbjct: 1186 LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLIL 1245

Query: 2070 QVSLPGHL 2077
            Q SL G L
Sbjct: 1246 QASLKGEL 1253



 Score =  122 bits (307), Expect = 3e-27
 Identities = 260/1339 (19%), Positives = 537/1339 (40%), Gaps = 180/1339 (13%)

Query: 354  NELLVTKNSIHQAALASFKAEIRHLLER----VDQVVREKEKLRSD------------LD 397
            NELL+ K       +   K+E+  L ++    V+Q  RE + L+              L 
Sbjct: 388  NELLLAKEE-QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLS 446

Query: 398  KAEKLKSLMASEVDDHHAAIERR---------NEYNLRKLDEEYKERIAALKNELRKERE 448
             +EK K  +  E+       E           N  +LR++ E  +  +     ++ +E E
Sbjct: 447  DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE 506

Query: 449  QILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 508
             + QQ      EL+Q++  A TE++ + + +     EN +    LL   E + E EN   
Sbjct: 507  SMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK----LLSQQELVPELENTIK 562

Query: 509  KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR 568
             LQ     V        D    E   +   LT+ ++++  + +   +++D    + E   
Sbjct: 563  NLQEK-NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621

Query: 569  AQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI 628
                 L L L     + ++ NS   E E     ++ N L   +E     E +KE+   D 
Sbjct: 622  R----LILELGKKVEQTIQYNS---ELE-----QKVNELTGGLE-----ETLKEKDQNDQ 664

Query: 629  CCLRLELEDKVRHYEKQLDETVVSC------KKAQENMKQRHENETHTLEKQISDLKNEI 682
               +L ++ KV   +K++    V        K + E  +   + E    +K+   LK  I
Sbjct: 665  KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHI 724

Query: 683  AELQGQAAVLKEAHHEATCRHEEE-------KKQLQVKLEEEKTHLQEKLRLQHEMELKA 735
             +L+ +  ++ E         E E       K QL   L+E  + + E    +  + +  
Sbjct: 725  TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQ 784

Query: 736  RLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTLEKEELRKEL 794
             + ++ A    E+  L  +   +EKV  L +E++   +E +    E K  L   E  K L
Sbjct: 785  AVGESLAKINEEKCNL--AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842

Query: 795  LEKHQRELQEGREKMETE------CNRRTSQIEAQFQSDCQKVTERCESALQSLEG---- 844
            L K   E+Q  +E ++++       N +T           ++V++ C  +    E     
Sbjct: 843  LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 902

Query: 845  -RYRQELKDLQEQQ--REEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQERE 901
             +  + LK L EQ+  R+ +++    KD L +  +   + L    + E+    +  + +E
Sbjct: 903  IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 962

Query: 902  MLEK---------TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
              EK           K+ L+S   E Q + ++LE LR+  +   + + D +++   S+K 
Sbjct: 963  KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD-LIQGAESYKN 1021

Query: 953  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
             L E E+       SEQL  ++      EH   R E +++ L    +    CET + +  
Sbjct: 1022 LLLEYEK------QSEQLDVEKERANNFEH---RIEDLTRQLRNSTLQ---CETINSDNE 1069

Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
            ++   I  LQS  K ++     L + ++   V  E E E         Q EQ ++E+   
Sbjct: 1070 DLLARIETLQSNAKLLE--VQILEVQRAKAMVDKELEAE-------KLQKEQKIKEHATT 1120

Query: 1073 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1132
            +  L+    Q  KE      ++ +  Q L+ ++     ++ ++    ++     E  +  
Sbjct: 1121 VNELEELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176

Query: 1133 LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK-IEESEASVEGFSELEN 1191
               N+  ++E + +   +   + + +++  ++  SSVQ+ E K  +  +  V+   EL +
Sbjct: 1177 --TNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234

Query: 1192 SEETRTE----SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1247
            S++  T+       LK ++   Q+Q+ +                    +  +K K+ E +
Sbjct: 1235 SKQAETDHLILQASLKGELEASQQQVEVYKIQL-------------AEITSEKHKIHEHL 1281

Query: 1248 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT 1307
              ++ +++       +    LQEE R  +    E      E  +   R+ + LK+ +  +
Sbjct: 1282 KTSAEQHQRTLSAYQQRVTALQEECRAAKA---EQATVTSEFESYKVRVHNVLKQQKNKS 1338

Query: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1367
             +    +   +  K E E L +L+ +L+ K++  Q ++       +  + L+ L+ E D 
Sbjct: 1339 MS----QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ------INVSELQTLQSEHDT 1388

Query: 1368 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG-NTQLLEKVKAHEIAWLHGTIQTHQ 1426
             + + N+ L+E V +   +   +   + EN  ++  +TQ + ++          T Q   
Sbjct: 1389 LLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL----------TSQNEV 1438

Query: 1427 ERPRVQNQVILEENTTLLGFQDKHFQ--HQATIAELELEKTKLQELTRKLKERVTIL--V 1482
             R   ++QV             +H Q  H+ T+  L+ + +K++    +LK   T    V
Sbjct: 1439 LRNSFRDQV-------------RHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485

Query: 1483 KQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1542
              +  L +  +       + D+     E  + +E    ++E +   ++  ++    LN  
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETT--DTESVSSASTYTQSLEQLLNSP 1543

Query: 1543 DSISNLKLGTLNGSQEEMWQK----TETVKQENAAVQKMVENLKKQISELK-IKNQQLDL 1597
            ++     L     ++EE+ QK    T++    N  +++        + ++K +K++   L
Sbjct: 1544 ETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRL 1603

Query: 1598 ENTELSQKNSQNQEKLQEL 1616
            E  +  +K++ N E L+ +
Sbjct: 1604 ERNQEREKSAANLEYLKNV 1622



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 167/758 (22%), Positives = 328/758 (43%), Gaps = 137/758 (18%)

Query: 347  ELTLALENEL-LVTKNSIHQ-----AALASFKAEIRHLLERVDQVVREKEKLRSDLDKAE 400
            E  L LE E+  + + S+ Q     + L  ++ E   L + ++++  EKE L+SDL    
Sbjct: 806  EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL---- 861

Query: 401  KLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 460
             L+   A+E         R    NL    EE  +  +  K+E+  E+E+   +       
Sbjct: 862  -LEMKNANEK-------TRLENQNLLIQVEEVSQTCS--KSEIHNEKEKCFIK------- 904

Query: 461  LEQEIEKAKTEENYIRDRLA-LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 519
             E E  K   E+  +RDR A L L ++S  ++  ++N + L+  + L  K++ NLE    
Sbjct: 905  -EHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN-DPLSSVKELEEKIE-NLEKECK 961

Query: 520  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLK 579
            EK   ++         ++ L   R E     + ++++++ L+SE ++  A  R L   ++
Sbjct: 962  EKEEKINKIKLVAVKAKKELDSSRKE----TQTVKEELESLRSEKDQLSASMRDL---IQ 1014

Query: 580  NSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV 639
             + S +                      N+ +E E   EQ+  +  R         E ++
Sbjct: 1015 GAESYK----------------------NLLLEYEKQSEQLDVEKER-----ANNFEHRI 1047

Query: 640  RHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNEIAELQ-GQAAVLKEA 695
                +QL  + + C+      E++  R E    TL+     L+ +I E+Q  +A V KE 
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIE----TLQSNAKLLEVQILEVQRAKAMVDKEL 1103

Query: 696  HHEATCRHEE---------EKKQLQVKLEEEKTHLQEKLR----LQHEMELKARLTQAQA 742
              E   + ++         E ++LQV+L++EK  LQ+ ++    ++ + +    +    A
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163

Query: 743  SFEREREGL-QSSAWTEEKVRGLTQEL------EQFHQEQLTSL---VEKHTLEKEELRK 792
             +ER  + L Q       K+  L QE+      ++  QE++TSL   V+++  EK    K
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE-EKNTKIK 1222

Query: 793  ELLEKHQRELQEGRE----------KMETECNRRTSQIE------AQFQSDCQKVTERCE 836
            +LL K ++EL + ++           ++ E      Q+E      A+  S+  K+ E  +
Sbjct: 1223 QLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK 1282

Query: 837  SALQSLE---GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTS 893
            ++ +  +     Y+Q +  LQE+ R  K+    E+  +T E    +  +   LK++K  S
Sbjct: 1283 TSAEQHQRTLSAYQQRVTALQEECRAAKA----EQATVTSEFESYKVRVHNVLKQQKNKS 1338

Query: 894  LVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE 953
              ++Q      K  +EHL  ++ + +  LQD ++   ++ ++   L  +   L   H + 
Sbjct: 1339 --MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396

Query: 954  LRER-------EEVLCQAGASEQLA----SQRLERLEMEHDQERQEMMSKLLAMENIHKA 1002
            L+E         E LC   +   +     +Q + +L  +++  R     ++  ++  H+ 
Sbjct: 1397 LQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456

Query: 1003 TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
            T ET  ++ ++M  ++ +L    K      SP+S  QS
Sbjct: 1457 TVETLQQQLSKMEAQLFQL----KNEPTTRSPVSSQQS 1490


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  204 bits (518), Expect = 1e-51
 Identities = 362/1785 (20%), Positives = 741/1785 (41%), Gaps = 252/1785 (14%)

Query: 353  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 412
            E + L+T+         S  +    L   ++ +  +KEKL  +++  +  K   ++E  +
Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606

Query: 413  HHAAIERRNEYNLRKLDE--EYKERIAALKNELRKEREQI---LQQAGKQRLELEQEIEK 467
             H  +++  E  L+  +      ERI  +   +R+E++++   L+     + E E+++++
Sbjct: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666

Query: 468  AKTEENYIRDRLALSLKENSRLENELLENAEKL-AEYENLTNKLQRNLENVLAEKFGDLD 526
            A+ E   +++++    K   +   EL E  ++L AE     +  +  +E +L+       
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS--- 1723

Query: 527  PSSAEFFLQEERLTQMRNEYE---RQCRVLQDQVDELQSELEEYRAQ-----GRVLRLPL 578
                     +E L +++ EYE   ++ + L  + D L  E+++ + Q      +   L  
Sbjct: 1724 --------MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA 1775

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                  +      G +   G  +EE + L+MS            +             D+
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPG-ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE 698
            + +Y +Q+D+        +E  KQ+++  + TLE + + L ++I+   G+  +L+E   E
Sbjct: 1835 INNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE---E 1890

Query: 699  ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTE 758
             T            K+      +QE+L         +R+T+ + + E E++ L+     +
Sbjct: 1891 VT------------KMNLLNQQIQEEL---------SRVTKLKETAEEEKDDLEERLMNQ 1929

Query: 759  EKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTS 818
              +  L   +  + Q+   + ++   LE E    + L+K   EL+E ++++  E  +  S
Sbjct: 1930 --LAELNGSIGNYCQDVTDAQIKNELLESE---MKNLKKCVSELEEEKQQLVKEKTKVES 1984

Query: 819  QIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEA 878
            +I  ++    Q   +         E   +   K+LQE  +E++     E  +L ++C   
Sbjct: 1985 EIRKEYLEKIQGAQK---------EPGNKSHAKELQELLKEKQQ----EVKQLQKDCIRY 2031

Query: 879  QELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSL 938
            QE +    +  K    V T+ ++ LE T KE+L   V  R++   +L   + + +  QS 
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEIT-KENLAQAVEHRKKAQAELASFKVLLDDTQSE 2090

Query: 939  LSDQILELKSSHKRELRE-REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAM- 996
             + ++L      K+EL+  +E V  Q    ++   +RLE+ E +H +E++ M  KL A+ 
Sbjct: 2091 AA-RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR 2149

Query: 997  -ENIH--------KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1047
             E +H        + T    D+E  ++      L S + ++   T  +S LQ     + +
Sbjct: 2150 REKVHLEETIGEIQVTLNKKDKEVQQLQ---ENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206

Query: 1048 E----EVEGDGALSLLQQGEQLLEENGDVL---LSLQRAHEQAVKENVKMATEISRLQQR 1100
            E    E +   A+   ++  +L E+N  VL   L     H + +K N+       ++ + 
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWES 2266

Query: 1101 LQKLEPGLVMSSC--LDEPATEFFGNTAEQTEPF-LQQNRTKQVEGVTR--RHVLSDLED 1155
              + E  L    C  L     E      E    +   QN   ++E   +  +  L+DL +
Sbjct: 2267 KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSN 2326

Query: 1156 --DEVRDLGSTGTSSVQRQEVKIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQ 1212
              ++ ++        +++QE  I+ S+ S E   ++L+ S E  +    L  +I+  +++
Sbjct: 2327 SLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR---LHEEINMKEQK 2383

Query: 1213 LMMLCADCDRASEKKQDLLFDVSVLK----KKLKMLERIPEASPKYKLLYEDVSREN-DC 1267
            ++ L       S K++ +   ++ L+    K++K LE +     +  ++ E+ +++  D 
Sbjct: 2384 IISLL------SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437

Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1327
              + +  ++T   E ++   +L + V  +       + +   +  LE+ +  + +E ++L
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497

Query: 1328 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
               +     +  KL+E + +     + + + EN ++  D  ++Q  + L + +    S  
Sbjct: 2498 ---IQEAAAENNKLKEEI-RGLRSHMDDLNSENAKL--DAELIQYREDLNQVITIKDSQQ 2551

Query: 1388 HVIEECK-QENQYLEGN-TQLLEKVKAHEIAW--LHGTIQTHQERPRVQNQVI--LEENT 1441
              + E + Q+N+ LE    +L EK+K  E A   L  +    QE  +  ++ I  L+ + 
Sbjct: 2552 KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611

Query: 1442 TLLGFQDKHFQHQATI----AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL 1497
            + L  Q    Q + T+    A+L++++ ++  L+            QK +    E EEEL
Sbjct: 2612 SQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS------SQKRI---AELEEEL 2662

Query: 1498 KAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQ 1557
              +  +      E++ K   L+ E + L  +  I+RNE  T  E       ++  L    
Sbjct: 2663 VCVQKEAAKKVGEIEDK---LKKELKHLHHDAGIMRNETETAEE-------RVAELARDL 2712

Query: 1558 EEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELN 1617
             EM QK   V +EN  +   +++  + +S L+      D  N EL +   +    L+EL 
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ---NSRDHANEELDELKRKYDASLKELA 2769

Query: 1618 QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHI 1677
            Q   + L  +E++    AL        N  EE            +SL          +H+
Sbjct: 2770 QLKEQGLLNRERD----ALLSETAFSMNSTEE------------NSL----------SHL 2803

Query: 1678 VQQENHLL-KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKL 1736
             +    LL KDE    + LH    L D   ++ S       L  E++ L  EL    +K 
Sbjct: 2804 EKLNQQLLSKDE----QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL----EKF 2855

Query: 1737 AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR 1796
             KS   + R A                 +Q   S  +VQ+L+  + ++     R+  +L+
Sbjct: 2856 RKSEEGKQRSA-----------------AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELK 2898

Query: 1797 VTQQEKEALKQEVMSLH---KQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNE 1853
              QQ+   + QE+  LH    QLQ    K+ A +I         +Q+ LSW    H +  
Sbjct: 2899 NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE----ELRQENLSWQHELHQLRM 2954

Query: 1854 EQQLLWQENERLQ-----TMVQNTKAELTHSREKVRQLESN------LLPKHQKHLNPSG 1902
            E+   W+ +ER         + +   +L+H +  +R+L S+      L  ++Q+  +P  
Sbjct: 2955 EKS-SWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPET 3013

Query: 1903 TMNPTEQEKL-----SLKRECDQFQKEQSPANRKVSQMNS----LEQELETIHLE----N 1949
            + +P   + L      L+ + +   KE      ++ Q+NS    L +E  T+ ++    +
Sbjct: 3014 SASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTS 3073

Query: 1950 EGLKKKQ----------VKLDEQLMEMQ--HLRSTATPSPSPHAWDLQLLQQQACPMVPR 1997
            + L++ Q            L++Q+ E+Q   L     P        +           P+
Sbjct: 3074 QSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQ 3133

Query: 1998 EQFLQLQRQLL----QAERINQHLQEELENRTSETNTPQGNQEQL 2038
            + F + Q+QL     +   + + L+EE + R +  N     +EQ+
Sbjct: 3134 QSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178



 Score =  197 bits (501), Expect = 9e-50
 Identities = 385/1784 (21%), Positives = 741/1784 (41%), Gaps = 291/1784 (16%)

Query: 379  LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAA 438
            L++ D+ ++E+ K   +  K +KLK    +++   +  IE         L  E +     
Sbjct: 75   LQQKDEALQEERKAADN--KIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132

Query: 439  LKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAE 498
             K++     E++  +  K +L+ ++E+    T +  +    A    ++S    E +   +
Sbjct: 133  SKHDKSSTEEEMEIEKIKHKLQEKEEL--ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190

Query: 499  KLAEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQ----EERLTQMRNEYERQCRV 552
            +L E E   + LQ  L    AE+     +    A F  Q    E+ L Q+  + + +   
Sbjct: 191  QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE- 249

Query: 553  LQDQVDELQSELEEYRAQ--GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMS 610
            +Q ++  LQ +LEE+     GR   + L        E  +  +  +      E N L  +
Sbjct: 250  MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309

Query: 611  IEAE-----LVIEQMK-EQHHRDICC--LRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 662
            +E E     +++E+M+ E   R +    L+ E+   +  +E Q  +     +     ++Q
Sbjct: 310  VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQ 368

Query: 663  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
            +H+ E       I  L+    ELQ     LK+ + +      E+  Q    +++ +  LQ
Sbjct: 369  KHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQ 428

Query: 723  EKLR----LQHEMELKARLTQAQASF-EREREGLQSSAWTEEKVRGLTQELEQFHQEQLT 777
            +K +      + + L+   T +Q SF +   EG Q  A TEE +  L + + +   E+  
Sbjct: 429  QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ--AVTEENIASLQKRVVELENEKGA 486

Query: 778  SLVEKHTLEKEELRKE---------LLEKHQRELQEGREKMETE----CNRRTSQIEAQF 824
             L+   ++E EEL+ E         LLE   R  +  RE  E       N+R+S  E   
Sbjct: 487  LLLS--SIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE--- 541

Query: 825  QSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE---L 881
                    E  +  L++   +  +EL  L  + +E + +  F K +L  + AE  +   L
Sbjct: 542  --------ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593

Query: 882  LKETLKREKTTSLVLTQEREMLEKTYK-------EHLNSMVVERQQLLQDLEDLRNVSET 934
             ++ +K+ +   +   + +  LE T +       E  +   VE++Q   + +     S T
Sbjct: 594  DQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQ-----SRT 648

Query: 935  QQSL-LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL 993
             + + L+D  +ELKS+ +    + ++ L       Q     LERL+           S++
Sbjct: 649  SEEISLNDAGVELKSTKQ----DGDKSLSAVPDIGQCHQDELERLK-----------SQI 693

Query: 994  LAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEG 1052
            L +E N HKA  E  ++   E + EIS L   I+E ++     S   S    + EE  + 
Sbjct: 694  LELELNFHKAQ-EIYEKNLDEKAKEISNLNQLIEEFKKNADNNS---SAFTALSEERDQL 749

Query: 1053 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGL---- 1108
               +  L    +L  +   + ++L  A  Q   +        + L +++  L        
Sbjct: 750  LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809

Query: 1109 ----VMSSCLDEPATEFFGNTA--EQTEPFLQQNRTKQVEGVTR-RHVLS---------- 1151
                V+ + LD+   +F   +      +  LQ   ++ +EG  R RH+ S          
Sbjct: 810  VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869

Query: 1152 --DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE--GFSELENSEETRTESWELKNQIS 1207
              +LE  ++  L       V+  +  IEE +  V    FS  E   +   E + L  +I 
Sbjct: 870  QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929

Query: 1208 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDC 1267
             L+EQL +L     RA E K++ + + + +   LK  +   E SP  ++  E++  E D 
Sbjct: 930  TLKEQLNLL----SRAEEAKKEQVEEDNEVSSGLK--QNYDEMSPAGQISKEELQHEFDL 983

Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1327
            L++E    + +   AL N KEL   V RL++EL  +++ ++  + L ++ +  ++E ++ 
Sbjct: 984  LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET-ERGEVEEDKE 1042

Query: 1328 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
            N          E  ++ V  +C     E  L+    E +  +  + + LEE +       
Sbjct: 1043 NK---------EYSEKCVTSKCQEI--EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091

Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ---THQERPRVQNQVILEENTTLL 1444
             ++   KQ NQ L+  T  ++ ++A EI+     IQ   T        + V L + T ++
Sbjct: 1092 ALV---KQMNQTLQDKTNQIDLLQA-EISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147

Query: 1445 G----FQDKHFQHQATIAELELEKTKLQELTRKLKERVT----ILVKQKDVLSHGEKEEE 1496
                    +H++ +     L LEK K ++L +KL+E +T    IL K ++   H    EE
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEK-EQLQKKLQEALTSRKAILKKAQEKERH--LREE 1204

Query: 1497 LKAMMHD---LQITCSEMQQKVELLRYESEKLQ-QENSILRNEITTLNEEDSISNLKLGT 1552
            LK    D   LQ    E  ++ E +  +  +LQ Q    +  ++ + ++++S S+     
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP--- 1261

Query: 1553 LNGSQEEMWQKTE-----------------TVKQENAAVQ--KMVENLKKQISELKIKNQ 1593
              G +E +++ TE                 +  ++ +A+Q    V  +K Q+ E++ +  
Sbjct: 1262 --GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319

Query: 1594 QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERC 1653
            +L+L+ +  + + ++  E++ +L +++ +     E E   +   E E    +L+++LE  
Sbjct: 1320 ELELKVSSTTSELTKKSEEVFQLQEQINKQ--GLEIESLKTVSHEAEVHAESLQQKLESS 1377

Query: 1654 KVQSSTL-----------------------VSSLEAELSE-----VKIQTHIVQQENHL- 1684
            ++Q + L                       VS L  +LSE      KIQT I++QE+ + 
Sbjct: 1378 QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437

Query: 1685 ---------LKDELEKMKQLH-------RCPD--------LSDFQQKISSVLSYNEKLLK 1720
                      K+  E++KQL        + P+            Q+K+ + L   ++ LK
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK 1497

Query: 1721 EKEALSEELN---SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNL 1777
            E ++L EEL+     +++L KS      +A ++ +  +   +  ++  +L   QE+   L
Sbjct: 1498 ENKSLQEELSLARGTIERLTKS------LADVESQVSAQNKEKDTVLGRLALLQEERDKL 1551

Query: 1778 -----EDTVQNVNLQMS--RMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT 1830
                    ++N +L  S   +K  L    ++KE L +E+ SL K  + A    W      
Sbjct: 1552 ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL-KSSKIAESTEW------ 1604

Query: 1831 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1890
                   Q+K     K   ++ +  + +  E ER+Q +V+  + E      K+R  E+N 
Sbjct: 1605 -------QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657

Query: 1891 LPKHQKHLNPSGTM-----------NPTEQEKLSLKRECDQFQKEQSPA--------NRK 1931
                ++       M              +Q+ L L+ E D+ + E  PA           
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717

Query: 1932 VSQMNSLEQELETIHLENEGLKKK-------QVKLDEQLMEMQH 1968
            +S   S+++ELE + +E E L KK       +  L E++ +++H
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH 1761



 Score =  194 bits (492), Expect = 1e-48
 Identities = 378/1859 (20%), Positives = 780/1859 (41%), Gaps = 241/1859 (12%)

Query: 315  RILDTWQEE--GIENSQEILKALDFSLDGNINLTELTLALENE---LLVTKNSIHQA--- 366
            +++D  Q+E    E   +IL      ++   N    T+  E E   +L+ K  +  A   
Sbjct: 273  QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332

Query: 367  -ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY-- 423
             +  + + E+ HLLE+ +Q  + + +L S     E+           H A +E +  +  
Sbjct: 333  LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ----------KHKAEMEEKTSHIL 382

Query: 424  NLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSL 483
            +L+K  +E +    ALK++  K    +LQ   +Q ++  Q I++       + D+L    
Sbjct: 383  SLQKTGQELQSACDALKDQNSK----LLQDKNEQAVQSAQTIQQ-------LEDQLQQKS 431

Query: 484  KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 543
            KE S+  N L     + A   +  +      + V  E    L          ++R+ ++ 
Sbjct: 432  KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASL----------QKRVVELE 481

Query: 544  NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS--EEVEANSGGIEPEHGLGS 601
            NE +    +   +++EL++E E+  +Q  +L    +   +  E  E +   I  +    +
Sbjct: 482  NE-KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540

Query: 602  EECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMK 661
            EE          + V+E    Q H+++  L LE+++          +  ++  K Q   K
Sbjct: 541  EE--------SGQDVLENTFSQKHKELSVLLLEMKEA---------QEEIAFLKLQLQGK 583

Query: 662  QRHENETHTLE-KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
            +  E +   L+ K++  ++ E          L++   +      EE     V+ E+  T 
Sbjct: 584  RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAST- 642

Query: 721  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
                   +H+      ++   A  E     L+S+    +K      ++ Q HQ++L  L 
Sbjct: 643  -------EHQSRTSEEISLNDAGVE-----LKSTKQDGDKSLSAVPDIGQCHQDELERL- 689

Query: 781  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
            +   LE        LE +  + QE  EK   E  +  S +  Q   + +K  +   SA  
Sbjct: 690  KSQILE--------LELNFHKAQEIYEKNLDEKAKEISNLN-QLIEEFKKNADNNSSAFT 740

Query: 841  SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
            +L     Q L  ++E     + + + +  +L    AEA+   +   + +     +LT++ 
Sbjct: 741  ALSEERDQLLSQVKELSMVTELRAQVK--QLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798

Query: 901  EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV 960
              L    K    S  V+ + L  +L+D++     Q +L+     +L++     L   E V
Sbjct: 799  HSLSIEAK----SKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854

Query: 961  LCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISR 1020
               +   E+L SQ L + E+E  +  Q ++ K   +E + + T E  D++  E+S  ++ 
Sbjct: 855  RHISSKVEEL-SQALSQKELEITKMDQLLLEKKRDVETLQQ-TIEEKDQQVTEISFSMTE 912

Query: 1021 LQSKIKE--------MQQATSPLSMLQSGCQVIGEEEVEGDGALSL-LQQGEQLLEENGD 1071
               ++ E        ++     L++L S  +   +E+VE D  +S  L+Q    +   G 
Sbjct: 913  KMVQLNEEKFSLGVEIKTLKEQLNLL-SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971

Query: 1072 VLLS-LQRAHEQAVKENVKMATEIS-------RLQQRLQKLEPGLVMSSCLDEPATEFFG 1123
            +    LQ   +   KEN +   ++         L QR+ +LE  L  ++  DE   E   
Sbjct: 972  ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL--ANLKDESKKEIPL 1029

Query: 1124 NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK--IEESEA 1181
            +  E+ E        K+ +  + + V S  ++ E+    +     V+ Q ++  +EE  A
Sbjct: 1030 SETERGEV----EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085

Query: 1182 SVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLF--DVSVLKK 1239
            + E F  L        +  +  NQI  LQ ++    A   +      D      V+++K+
Sbjct: 1086 AEEQFQALVKQMNQTLQ--DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143

Query: 1240 KLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDE 1299
             + +      +S  +K    ++  +   L++E   ++ +  EAL + K +  +    +  
Sbjct: 1144 TVVISPPCTGSSEHWK---PELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200

Query: 1300 LKK-MEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASL 1358
            L++ +++  + +  L++ +DE   ENE +   + +LQ ++ +  +  +   D        
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD------QQ 1254

Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHH---VIEE--C------KQENQYLEGNTQL- 1406
            E+    P          LEE + +    HH   V+E   C       ++   L+G T + 
Sbjct: 1255 ESCSSTPG---------LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVA 1305

Query: 1407 -----LEKVKAHEIAWLHGTIQTHQERPRVQNQVI-LEENTTLLGFQD---KHFQHQATI 1457
                 L++++A ++        T  E  +   +V  L+E     G +    K   H+A +
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365

Query: 1458 ----AELELEKTKLQ----ELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCS 1509
                 + +LE ++LQ    E  R+L+ ++  L K   ++S  +KEE++  +   L     
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQK---LIS--KKEEDVSYLSGQLS---- 1416

Query: 1510 EMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ 1569
              +++  L + ++E ++QE+ +++   T L  +    + ++  L     EM QK E + +
Sbjct: 1417 --EKEAALTKIQTEIIEQED-LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473

Query: 1570 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ--- 1626
            E+ A Q++   L+  +    I  ++   EN  L ++ S  +  ++ L + L ++  Q   
Sbjct: 1474 ESRAKQQIQRKLQAAL----ISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529

Query: 1627 --KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL 1684
              KEK+     L   ++E+  L  E++R  +++ +L SS E+    +K+    + ++   
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES----LKLALEGLTEDKEK 1585

Query: 1685 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEH 1744
            L  E+E +K   +  + +++Q+K   +    E LL+  E +S E          +  ++H
Sbjct: 1586 LVKEIESLKS-SKIAESTEWQEKHKELQKEYEILLQSYENVSNE----------AERIQH 1634

Query: 1745 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEA 1804
             +  ++QE+   +     L+S     +E  + L++  Q +     +M+   +  QQ+   
Sbjct: 1635 VVEAVRQEK---QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691

Query: 1805 LKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1862
            L++E   L  ++  AG   K     + +  + +  + +R+  +     ++++ Q L  E 
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY--ETLSKKFQSLMSEK 1749

Query: 1863 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMN----PTEQEKLSLKRE- 1917
            + L   VQ+ K ++  +  K   LE+     +Q ++   GT +      EQ+ LS+    
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809

Query: 1918 -CDQFQKEQSPANRKVS-------QMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHL 1969
             C +       AN  VS       ++N+  Q+++ +     GL++++ K  E    +++ 
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869

Query: 1970 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ-------AERINQHLQEELE 2022
            ++T     S    +L++LQ++   M    Q  Q+Q +L +       AE     L+E L 
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQ--QIQEELSRVTKLKETAEEEKDDLEERLM 1927

Query: 2023 NRTSETNTPQGNQEQLVT--VMEERMIEVEQK--LKLVKRLLQEKVNQLKEQVSLPGHL 2077
            N+ +E N   GN  Q VT   ++  ++E E K   K V  L +EK   +KE+  +   +
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI 1986



 Score =  190 bits (482), Expect = 1e-47
 Identities = 365/1829 (19%), Positives = 748/1829 (40%), Gaps = 263/1829 (14%)

Query: 370  SFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA-----IERRNEYN 424
            S   EI+ L E+++ + R +E  +  +++  ++ S +    D+   A      E ++E++
Sbjct: 923  SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982

Query: 425  LRKLDEEYKERI--AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS 482
            L K + E ++R   AAL N     R+++LQ+  +    LE+E+   K E    +  + LS
Sbjct: 983  LLKKENEQRKRKLQAALIN-----RKELLQRVSR----LEEELANLKDES---KKEIPLS 1030

Query: 483  LKENSRLENELLENAEKLAEYENLTNKLQR---NLENVLAEKFGDLD---PSSAEFFLQE 536
              E   +E +  EN E   +   +T+K Q     L+  ++EK  +L        E    E
Sbjct: 1031 ETERGEVEEDK-ENKEYSEKC--VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087

Query: 537  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
            E+   +  +  +  +   +Q+D LQ+E+ E +A    +   L  S ++  + +S  +  E
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQA----IIQKLITSNTDASDGDSVALVKE 1143

Query: 597  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
              + S  C   +         E  K +    I  L  E E   +  ++ L       KKA
Sbjct: 1144 TVVISPPCTGSS---------EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194

Query: 657  QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE---EEKKQLQVK 713
            QE  K+RH             L+ E+ + +     L+E   E +  +E   ++ +QLQ++
Sbjct: 1195 QE--KERH-------------LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239

Query: 714  LEEE------KTHLQE-------------KLRLQHEME--LKARLTQAQASFEREREGLQ 752
            + E        T  QE             K   QH  +  L++ L     S   +   LQ
Sbjct: 1240 VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ 1299

Query: 753  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
                    V  +  +L++   E++  L  K +    EL K+  E  Q + Q  ++ +E E
Sbjct: 1300 GGT----SVAQIKAQLKEIEAEKV-ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354

Query: 813  CNRRTSQIEAQFQSDCQKVTERCESALQSLEG--RYRQELKDLQEQQREEKSQWEFEKDE 870
              +  S          Q+  E  +  +  LE     + +L +LQ+   +++    +   +
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414

Query: 871  LTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRN 930
            L+++ A   ++  E +++E     + TQ  EM  K + E +  + VE  ++ Q  E++  
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIKALHTQ-LEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473

Query: 931  VSETQQSL---LSDQILELKSSHKRELREREEVLCQAGASEQLASQR--LERLEMEHDQE 985
             S  +Q +   L   ++  K + K     +EE+    G  E+L      +E      ++E
Sbjct: 1474 ESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533

Query: 986  RQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVI 1045
            +  ++ +L  ++          DR   E  +  S  +S    ++  T     L    + +
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593

Query: 1046 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1105
               ++      +  Q+  + L++  ++LL   +++E    E  ++   +  ++Q  Q+L 
Sbjct: 1594 KSSKIAES---TEWQEKHKELQKEYEILL---QSYENVSNEAERIQHVVEAVRQEKQELY 1647

Query: 1106 PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVR-DLGST 1164
             G + S+  ++  TE     AEQ    +++   K  +   ++ +  + E+D +R ++   
Sbjct: 1648 -GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
            G ++ +  E  +  + +  E   ELE           +K +   L ++   L ++ D  S
Sbjct: 1707 GDTAKECMETLLSSNASMKE---ELER----------VKMEYETLSKKFQSLMSEKDSLS 1753

Query: 1225 EKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDV------SRENDCLQEELRMMETR 1278
            E+ QDL   +     K   LE   +   +  +  E        + E D L    R   + 
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813

Query: 1279 YDEALENNKELTAEVFRLQDE----LKKMEEVTETFLSLEKSYDEVK-----IENEELNV 1329
               + ++     ++ F   DE    L++++++ E    LE+   + K     +ENE+  +
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873

Query: 1330 L--VLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
            L  +    G+++ LQE V +            NL          LNQ ++E + RV  + 
Sbjct: 1874 LSQISTKDGELKMLQEEVTKM-----------NL----------LNQQIQEELSRVTKLK 1912

Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQER---PRVQNQVILEENTTLL 1444
               EE K +          LE+   +++A L+G+I  + +     +++N+++  E   L 
Sbjct: 1913 ETAEEEKDD----------LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNL- 1961

Query: 1445 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1504
                     +  ++ELE EK +L  +  K K    I  +  + +   +KE   K+   +L
Sbjct: 1962 ---------KKCVSELEEEKQQL--VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010

Query: 1505 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLN--EEDSISNLKLGTLNGSQ----- 1557
            Q    E QQ+V+ L+ +  + Q++ S L   +  L   + +S  +L++   N +Q     
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 1558 --------------EEMWQKTETVKQENAAVQKMVENLKKQI-SELKIKNQQLDLENTEL 1602
                          ++   +   V  +N  ++K +++ K+ + S++K K++ L+    + 
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQA 2130

Query: 1603 SQKNSQNQEKLQELNQRLTEMLCQKEKEPG--NSALEEREQEKFNLKEELERCKVQSSTL 1660
             +K+ + ++ +QE    L       E+  G     L ++++E   L+E L+    Q +  
Sbjct: 2131 EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF 2190

Query: 1661 VSSL------------EAELSEVKIQTHIVQQENHL---------LKDELEK----MKQL 1695
              S+            EA+  E K    I  +E  +         LKD+L +    M++L
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250

Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKEK--EALSEELNSCVDKLAKSSLLEH----RIATM 1749
                   +  ++I    +  E  L++K  + L  E    + +L ++  L H     +A +
Sbjct: 2251 KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL 2310

Query: 1750 KQEQKSWEHQSASLKSQLVASQEKVQNLED-------TVQNVNLQMSRMKSDLRVTQQEK 1802
            + E KS + Q   L + L   +E+  NLE         +QN      ++++DL+ +++  
Sbjct: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT 2370

Query: 1803 EALKQEV-MSLHKQLQNAGGKSWAPEIA------THPSGLHNQQKRLSWDKLDHL-MNEE 1854
              L +E+ M   K +    GK  A ++A       H   +   +  LS ++ +++ + EE
Sbjct: 2371 SRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEE 2430

Query: 1855 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSL 1914
             +    +  +L   ++  K E    + ++     ++           G     E+  LS+
Sbjct: 2431 NKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSI 2490

Query: 1915 KRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLME-MQHLRSTA 1973
              E DQ  +E +  N      N L++E+  +    + L  +  KLD +L++  + L    
Sbjct: 2491 ILEKDQLIQEAAAEN------NKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544

Query: 1974 TPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQG 2033
            T   S     L++  QQ   +    ++ +L+ +L ++E  N+ L+          N  Q 
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKEL--ENKYAKLEEKLKESEEANEDLRRSF-------NALQE 2595

Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE 2062
             ++ L   +E   + + Q  + V  L +E
Sbjct: 2596 EKQDLSKEIESLKVSISQLTRQVTALQEE 2624



 Score =  177 bits (448), Expect = 1e-43
 Identities = 380/1859 (20%), Positives = 758/1859 (40%), Gaps = 311/1859 (16%)

Query: 409  EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKA 468
            E+++   A+E+  E   +KL E    R A LK    KER             L +E+++ 
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH------------LREELKQQ 1208

Query: 469  KTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS 528
            K + N ++++     KEN  + ++L +   ++   E++  KL    +         L+  
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQL--QIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266

Query: 529  SAEFFLQEERLTQMRNE---------YERQCRVLQD--QVDELQSELEEYRAQGRVLRLP 577
               F   E+  TQ   E         +      LQ    V +++++L+E  A+   L L 
Sbjct: 1267 L--FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELK 1324

Query: 578  LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDI------CCL 631
            + ++ SE  + +    + +     E+ N   + IE+   +    E H   +        L
Sbjct: 1325 VSSTTSELTKKSEEVFQLQ-----EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379

Query: 632  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 691
            ++   + +R  + +LDE      K +E++      +    E  ++ ++ EI E +     
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYL-SGQLSEKEAALTKIQTEIIEQEDLIKA 1438

Query: 692  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA-QASFEREREG 750
            L          H+E  KQLQV+L E K   +E   +  E   K ++ +  QA+    +E 
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEE---IGEESRAKQQIQRKLQAALISRKEA 1495

Query: 751  LQSSAWTEEKV---RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE 807
            L+ +   +E++   RG  + L +   + + S V     EK+ +   L       LQE R+
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLAL-----LQEERD 1549

Query: 808  KMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG------RYRQELKDLQEQQREEK 861
            K+ TE +R  S +E Q       ++  CES   +LEG      +  +E++ L+  +  E 
Sbjct: 1550 KLITEMDR--SLLENQ------SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601

Query: 862  SQWEFEKDELTQE----CAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE 917
            ++W+ +  EL +E        + +  E  + +     V  +++E+  K      N    E
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661

Query: 918  RQ--QLLQDLEDLRNVSETQQSLLSDQILELKSSHKR----------ELREREEVLCQAG 965
            +Q  +  Q++E+++            +ILEL+  + R            +E  E L  + 
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721

Query: 966  ASEQLASQRLERLEMEHD---QERQEMMSKLLAME------------NIHK-ATCETADR 1009
            AS +   + LER++ME++   ++ Q +MS+  ++             N+ K A  E  ++
Sbjct: 1722 ASMK---EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEK 1778

Query: 1010 ERAEMSTEISRLQSKIKEMQQATSPLSM------------LQSGCQVIGEEEVEGDGALS 1057
               + +      QS   E ++  S LSM             +S    + ++    D   +
Sbjct: 1779 HDNQTNVTEEGTQSIPGETEEQDS-LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837

Query: 1058 LLQQGEQLLEENGDVLLSLQRAHE-QAVKENVK--MATEISRLQQRLQKLEPGLVMSSCL 1114
             LQQ +QL E    +    Q+  E     EN K  + ++IS     L+ L+  +   + L
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897

Query: 1115 DEPATEFFGN------TAEQTEPFLQQNRTKQV-----------EGVTRRHVLSDLEDDE 1157
            ++   E          TAE+ +  L++    Q+           + VT   + ++L + E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957

Query: 1158 VRDLGSTGTSSVQRQEVKIEE-----SEASVEGFSELENSEE---TRTESWELKNQISQL 1209
            +++L    +   + ++  ++E     SE   E   +++ +++    ++ + EL+  + + 
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEK 2017

Query: 1210 QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK---------------- 1253
            Q+++  L  DC R  EK       +S L++ +K LE +   S K                
Sbjct: 2018 QQEVKQLQKDCIRYQEK-------ISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 1254 ---------YKLLYEDVSREND-CLQEELRMMETRYDEALENNKELTAEVFRLQDE--LK 1301
                     +K+L +D   E    L + L++ +      L++NKE      + +DE   +
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKE-----LQSNKESVKSQMKQKDEDLER 2125

Query: 1302 KMEEVTETFLSLEKSYDE---------VKIENE--ELNVLVLRLQGKIEKLQESVVQRC- 1349
            ++E+  E  L  +K+  E         V +E    E+ V + +   ++++LQE++     
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL-- 1407
                +  S+ +L+ + D       + ++E     R     I+  ++E +  E N  +L  
Sbjct: 2186 QLAAFTKSMSSLQDDRD-------RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238

Query: 1408 ---------EKVKA------HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF--QDKH 1450
                     E++K       H+        QT  +  +     +  EN  LL    + +H
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298

Query: 1451 FQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSE 1510
              H +     + E  KL+   + LK+++T      D+ +  EK +E K    +L+    +
Sbjct: 2299 LYHSS-----QNELAKLESELKSLKDQLT------DLSNSLEKCKEQKG---NLEGIIRQ 2344

Query: 1511 MQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQE 1570
             +  ++  ++  E+L+ +    R   + L+EE ++   K+ +L   +EE  Q        
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ-------- 2396

Query: 1571 NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE 1630
              A+ ++ +   K+I EL+    Q + EN  L ++N +  +K  +L + L  +  +KE  
Sbjct: 2397 -VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI--KKENI 2453

Query: 1631 PGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKD 1687
               + L+   +   +L+ + +R       L    E  LS +  +  ++Q+   EN+ LK+
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE---ERHLSIILEKDQLIQEAAAENNKLKE 2510

Query: 1688 ELEKMKQLHRCPDLSDFQQKISS-VLSYNEKL---LKEKEALSEELNSCVDKLAKSSLLE 1743
            E+  ++      DL+    K+ + ++ Y E L   +  K++  ++L     +L ++  LE
Sbjct: 2511 EIRGLRS--HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV--QLQQNKELE 2566

Query: 1744 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-- 1801
            ++ A ++++ K  E  +  L+    A QE+ Q+L   ++++ + +S++   +   Q+E  
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626

Query: 1802 ----KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQL 1857
                   LK +   +H+   +A   S    IA     L   QK  +       + E +  
Sbjct: 2627 LGLYHAQLKVKEEEVHR--LSALFSSSQKRIAELEEELVCVQKEAA-----KKVGEIEDK 2679

Query: 1858 LWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1917
            L +E + L       + E   + E+V +L  +L+   QK L  +        +  S  R 
Sbjct: 2680 LKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRS 2739

Query: 1918 CDQFQKEQSPANRKVSQM-NSLEQEL-ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATP 1975
                Q  +  AN ++ ++    +  L E   L+ +GL  ++   D  L E     ++   
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE--RDALLSETAFSMNSTEE 2797

Query: 1976 SPSPHAWDLQLLQQQACPMVPREQFLQLQRQL----------------LQAERINQHLQE 2019
            +   H   L+ L QQ   +   EQ L L  QL                LQ ER   HL  
Sbjct: 2798 NSLSH---LEKLNQQL--LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER--DHLWN 2850

Query: 2020 ELE----------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQE--KVNQ 2066
            ELE             ++ +T     + L   M     + ++ LK +K L Q+  ++NQ
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909



 Score =  141 bits (355), Expect = 8e-33
 Identities = 291/1452 (20%), Positives = 573/1452 (39%), Gaps = 215/1452 (14%)

Query: 421  NEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            N Y L+++D+  KERIA L+ E +K +E   Q    ++  L  +I     E   +++ + 
Sbjct: 1836 NNY-LQQIDQ-LKERIAGLEEEKQKNKE-FSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
                 N +++ EL    +     E   + L+  L N LAE  G +       + Q+    
Sbjct: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN-----YCQDVTDA 1947

Query: 541  QMRNEY-ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGL 599
            Q++NE  E + + L+  V EL+ E ++           +K     E E     +E   G 
Sbjct: 1948 QIKNELLESEMKNLKKCVSELEEEKQQL----------VKEKTKVESEIRKEYLEKIQGA 1997

Query: 600  GSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 659
              E  N  +     EL+ E+ +E       C+R +  +K+      L+ TV + +  Q  
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ--EKI----SALERTVKALEFVQTE 2051

Query: 660  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEAT---CRHEEEKKQLQVKLEE 716
             ++  E     L + +   K   AEL     +L +   EA      + + KK+LQ   E 
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111

Query: 717  EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQE-- 774
             K+ +++K     + +L+ RL QA+    +E++ +Q      EK+  L +E     +   
Sbjct: 2112 VKSQMKQK-----DEDLERRLEQAEEKHLKEKKNMQ------EKLDALRREKVHLEETIG 2160

Query: 775  QLTSLVEKHTLEKEELRKEL---------LEKHQRELQEGREKMETECNRRTSQIEAQFQ 825
            ++   + K   E ++L++ L           K    LQ+ R+++  E  +   +     Q
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220

Query: 826  SDCQKVTERCESALQSLEGRYRQ------ELKDLQEQQREEKSQWEFEKDELTQECAEAQ 879
            S  +++  + E     L+ + RQ      ELK    +   +K  WE +     Q   + Q
Sbjct: 2221 SKEEEIRLK-EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK----AQTEVQLQ 2275

Query: 880  ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET----- 934
            + + +TL+ E    L   +E   L  + +  L  +  E + L   L DL N  E      
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335

Query: 935  --------------QQSLLSDQILELKSSHKRELRER---------EEVLCQAGASEQLA 971
                          Q S  S + LE      REL  R         ++++      E+  
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI 2395

Query: 972  SQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE--MQ 1029
               +  L  +HD+E +E+   LL+ E       E  +++  + + ++      IK+  +Q
Sbjct: 2396 QVAIAELRQQHDKEIKEL-ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454

Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVK 1089
            Q     S ++S   +  + +        ++   +QL E +  ++L   +  ++A  EN K
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRD-------RIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507

Query: 1090 MATEISRLQQRLQ-------KLEPGLVM-SSCLDEPATEFFGNTAEQTEPFLQQNRTKQV 1141
            +  EI  L+  +        KL+  L+     L++  T       +  E  LQQN+  + 
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567

Query: 1142 EGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWE 1201
            +       L + E+    DL  +  +  + ++   +E E+     S+L        E   
Sbjct: 2568 KYAKLEEKLKESEEAN-EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626

Query: 1202 LKNQISQL---QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1258
            L    +QL   +E++  L A    + ++  +L  ++  ++K+    +++ E   K K   
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA--KKVGEIEDKLKKEL 2684

Query: 1259 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF----LSLE 1314
            + +  +   ++ E    E R  E   +  E+  ++  +  E K +    ++F     SL+
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ 2744

Query: 1315 KSYDEVKIENEELN---------VLVLRLQGKIEKLQESVVQRCDCCL---WEASLENLE 1362
             S D    E +EL          +  L+ QG + + +++++      +    E SL +LE
Sbjct: 2745 NSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLE 2804

Query: 1363 ------IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA 1416
                  +  D  +L L+  LE+   +V+S    +   + E  +L      LEK +  E  
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE---LEKFRKSEEG 2861

Query: 1417 WLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKE 1476
                  Q       VQ+  + +  ++L   +D+          L  E   LQ+   ++ +
Sbjct: 2862 KQRSAAQPSTSPAEVQS--LKKAMSSLQNDRDR----------LLKELKNLQQQYLQINQ 2909

Query: 1477 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1536
             +T L                    H L+    E Q K +  +   E+L+QEN   ++E+
Sbjct: 2910 EITEL--------------------HPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949

Query: 1537 TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE---LKIKNQ 1593
              L  E S   +    +   +E+         Q+ + +Q ++  L+   S+   LK++ Q
Sbjct: 2950 HQLRMEKSSWEIHERRM---KEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006

Query: 1594 QLDLENTELSQKNSQN----------------------QEKLQELNQRLTEMLCQK---- 1627
            +     T  S   SQN                      + ++Q+LN   +++L +K    
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLS 3066

Query: 1628 -EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL-L 1685
             +    + +L E +Q   +L   L  C V     V  L+A    + +     Q++N +  
Sbjct: 3067 IQLCDTSQSLRENQQHYGDL---LNHCAVLEKQ-VQELQAGPLNIDVAPGAPQEKNGVHR 3122

Query: 1686 KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHR 1745
            K + E++++  +    S+ QQ++ +     +++ + ++ L EE +  V      S+ E +
Sbjct: 3123 KSDPEELREPQQ--SFSEAQQQLCNT---RQEVNELRKLLEEERDQRVAAENALSVAEEQ 3177

Query: 1746 IATMKQEQKSWE 1757
            I  +  E   W+
Sbjct: 3178 IRRL--EHSEWD 3187



 Score =  131 bits (330), Expect = 6e-30
 Identities = 288/1451 (19%), Positives = 590/1451 (40%), Gaps = 227/1451 (15%)

Query: 313  VERILDTWQEEGIENSQEILKALDFSLDGNIN--LTELTLA-LENELLVTKNSIHQAALA 369
            V ++ +T +EE  +  + ++  L   L+G+I     ++T A ++NELL       ++ + 
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLA-ELNGSIGNYCQDVTDAQIKNELL-------ESEMK 1959

Query: 370  SFKAEIRHLLERVDQVVREKEKLRSDLDK--AEKLKSLMASEVDDHHA----AIERRNEY 423
            + K  +  L E   Q+V+EK K+ S++ K   EK++       +  HA     + +  + 
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019

Query: 424  NLRKLDEE---YKERIAAL----------KNELRKERE---QILQQAGKQRLELEQEIEK 467
             +++L ++   Y+E+I+AL          + E +K+ E   + L QA + R + + E+  
Sbjct: 2020 EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079

Query: 468  AKTEENYIRDRLALSLKENSRLENELLENAEKLAEY-----ENLTNKLQRNLENVLAEKF 522
             K   +  +   A  L +N +L+ EL  N E +        E+L  +L++  E  L EK 
Sbjct: 2080 FKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139

Query: 523  G---DLDPSSAEFFLQEERLTQMR---NEYERQCRVLQDQVDELQSELEEYRA------- 569
                 LD    E    EE + +++   N+ +++ + LQ+ +D   ++L  +         
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199

Query: 570  -QGRVLRLPLK--NSPSEEVEANSGGIEPEHGLGSEECNPL-----NMSIE-AELVIEQM 620
             + RV+    K     S+ +++     E E  L  + C+ L      MSI   EL I   
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255

Query: 621  KEQHHRDI----CCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQIS 676
            + +H + I        ++L+ KV    +  ++ ++S  +   ++    +NE   LE ++ 
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK 2315

Query: 677  DLKNEIAELQGQAAVLKE--AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELK 734
             LK+++ +L       KE   + E   R +E   Q       + ++ Q +  LQ   EL 
Sbjct: 2316 SLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ-----NSKFSYEQLETDLQASRELT 2370

Query: 735  ARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL 794
            +RL +     E++   L S    EE ++    EL Q H +++  L E    ++EE    L
Sbjct: 2371 SRLHEEINMKEQKIISLLSG--KEEAIQVAIAELRQQHDKEIKEL-ENLLSQEEEENIVL 2427

Query: 795  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 854
             E++++ + +  + MET    +   I+ + Q D      +  S+LQ+   R   + + L+
Sbjct: 2428 EEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS---FVKSMSSLQNDRDRIVGDYQQLE 2484

Query: 855  EQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSM 914
            E+          EKD+L QE A     LKE ++  ++    L  E   L+          
Sbjct: 2485 ERH----LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLD---------- 2530

Query: 915  VVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQR 974
              E  Q  +DL  +  + ++QQ     Q+LE++    +EL  +                +
Sbjct: 2531 -AELIQYREDLNQVITIKDSQQK----QLLEVQLQQNKELENK--------------YAK 2571

Query: 975  LERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP 1034
            LE    E ++  +++     A++            E+ ++S EI  L+  I ++ +  + 
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQ-----------EEKQDLSKEIESLKVSISQLTRQVTA 2620

Query: 1035 LSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEI 1094
            L               + +G L L     ++ EE                 E  +++   
Sbjct: 2621 L---------------QEEGTLGLYHAQLKVKEE-----------------EVHRLSALF 2648

Query: 1095 SRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE 1154
            S  Q+R+ +LE  LV   C+ + A +  G   ++ +  L+        G+ R    ++  
Sbjct: 2649 SSSQKRIAELEEELV---CVQKEAAKKVGEIEDKLKKELK--HLHHDAGIMRNE--TETA 2701

Query: 1155 DDEVRDLGSTGTSSVQRQEVKIEESE---ASVEGFSELENSEETRTESWELKNQISQLQE 1211
            ++ V +L        Q+  +  +E++   A ++ F    +S         L+N      E
Sbjct: 2702 EERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS---------LQNSRDHANE 2752

Query: 1212 QLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEE 1271
            +L       D    K    L +++ LK++  +L R  +A     LL E     N   +  
Sbjct: 2753 EL-------DELKRKYDASLKELAQLKEQ-GLLNRERDA-----LLSETAFSMNSTEENS 2799

Query: 1272 LRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV 1331
            L  +E    + L  +++L     +L+D   +++  ++   SL+   D +  E E+     
Sbjct: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR--- 2856

Query: 1332 LRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECV---PRVRSVHH 1388
               +GK     +      +    + ++ +L+ + D  + +L    ++ +     +  +H 
Sbjct: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHP 2916

Query: 1389 VIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERP--RVQNQVILEENTTLLGF 1446
            +  + ++     +    + E+++   ++W H   Q   E+    +  + + E+    +  
Sbjct: 2917 LKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISD 2976

Query: 1447 QDKHFQH-QATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQ 1505
            +D+   H Q  I EL    ++ Q L  + + + +    +      G +      ++++ +
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQAS---PETSASPDGSQN-----LVYETE 3028

Query: 1506 ITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTE 1565
            +  +++   ++ +  +  ++QQ NS      + L EE +  +++L   + S  E  Q   
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLNS----NFSQLLEEKNTLSIQLCDTSQSLRENQQHYG 3084

Query: 1566 TVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN----SQNQEKLQELNQRLT 1621
             +    A        L+KQ+ EL+     +D+      +KN      + E+L+E  Q  +
Sbjct: 3085 DLLNHCAV-------LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFS 3137

Query: 1622 E---MLCQKEKEPG--NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1676
            E    LC   +E       LEE   ++   +  L   + Q   L  S E + S   I   
Sbjct: 3138 EAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHS-EWDSSRTPIIGS 3196

Query: 1677 IVQQENHLLKD 1687
               QE  LL D
Sbjct: 3197 CGTQEQALLID 3207


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  200 bits (509), Expect = 1e-50
 Identities = 408/1927 (21%), Positives = 803/1927 (41%), Gaps = 278/1927 (14%)

Query: 310  HASVERILDTWQEEGIENSQEILKALDFSLDGNIN-LTELTLALENELLVTKNSIHQAAL 368
            +  +E  +  +Q + +E  +++   L+  L    N +T+LT  ++ +  V K+ +    L
Sbjct: 662  YKQMENDIQLYQSQ-LEAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDLLCNLEL 718

Query: 369  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEY----- 423
               + +I  L + +++ V E E LR ++    +LKSL  SEV+     I+ ++E      
Sbjct: 719  ---EGKITDLQKELNKEVEENEALREEVILLSELKSL-PSEVERLRKEIQDKSEELHIIT 774

Query: 424  -NLRKLDEE--YKE-RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRL 479
                KL  E  +KE R+  L  E+ K ++ +       +   +QE +  KT       + 
Sbjct: 775  SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK-STDQEFQNFKTLHMDFEQKY 833

Query: 480  ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 539
             + L+EN R+  E++  +++  ++++    L+  L    + K  +L   + E   +   +
Sbjct: 834  KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL----SYKTQELQEKTREVQERLNEM 889

Query: 540  TQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG- 598
             Q++ + E +   LQ    E +  L   + Q  +  +       ++++     ++ E   
Sbjct: 890  EQLKEQLENRDSTLQTV--EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947

Query: 599  LGSEECNPLNMSIEAELVIEQMKE---QHHRDICCLRLELEDKVR---HYEKQLDETVVS 652
            L S+  + +NM+I+ +  +    E   QH   I  L+ ++ ++V    H E+   ET   
Sbjct: 948  LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007

Query: 653  CKKAQENMKQRHENETHTLEKQISDLK-NEIAELQGQAAVLKEAHHEATCRHEE---EKK 708
             ++    + ++ + E    +   +D+K NEI E Q +   L +  +E     E    EK+
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067

Query: 709  QLQVKLEEE---KTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSS-----AWTEE 759
            QL+  L+E        QE+LRL   E++ +  +   + +   ++EG  S      A  EE
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127

Query: 760  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
            K++  +Q+L++  Q+ L    E   ++K+    E L+   +  +   E METE      +
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187

Query: 820  IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ---ECA 876
            +   ++       ER    L+ L+  +  E   L+   RE ++     K+EL        
Sbjct: 1188 LNENYEEVKSITKER--KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK 1245

Query: 877  EAQELLKETLKR--EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 934
            E QE + E  +   EKT  ++ TQ+ E      +E +  ++ E Q+LL ++++   VSET
Sbjct: 1246 EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI-PVLHEEQELLPNVKE---VSET 1301

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM-EHDQERQEMMSKL 993
            Q+++   ++L  +S+ K               S  LA   +ERL + E  QE QE +  L
Sbjct: 1302 QETMNELELLTEQSTTKD--------------STTLARIEMERLRLNEKFQESQEEIKSL 1347

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ-QATSPLSMLQSG---CQVIGEEE 1049
                +  K   E  + +  ++   I    +KI+E Q +    L+M +      +++ E E
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407

Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
                   +LL+   ++L     +   LQ +H++ +K   K   ++ RLQ+ LQ       
Sbjct: 1408 QFKPKDSALLRIEIEML----GLSKRLQESHDE-MKSVAKEKDDLQRLQEVLQS------ 1456

Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1169
             S  L E   E      E  E     +   + +  T   +  +L + E      T  S++
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE------TEISTI 1510

Query: 1170 QRQEVKIEESEASVEGFSELENSEETRTESWELKN--QISQLQEQLMMLCADCDRASEKK 1227
            Q+Q   I +         +L+N  +   E  E  N  QIS++QE++  L    +    K 
Sbjct: 1511 QKQLEAIND---------KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561

Query: 1228 QDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNK 1287
              L    S+  K L++  R+ E+  + +++ ++   E   +QE L++     D+  EN K
Sbjct: 1562 SALQ---SIESKMLELTNRLQESQEEIQIMIKE-KEEMKRVQEALQIER---DQLKENTK 1614

Query: 1288 ELTAEVFRLQD---ELKKMEEVTET------FLSLEKSYDEVKIENEELNVLVLRL---- 1334
            E+ A++   Q+   +  KM  V ET         L++ ++  K+  E +    +RL    
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674

Query: 1335 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1394
               +E+++    +R D    E   E L++E D    QL + L E + R        EE K
Sbjct: 1675 HENLEEMRSVTKERDDLRSVE---ETLKVERD----QLKENLRETITRDLEKQ---EELK 1724

Query: 1395 QENQYLEGNTQLLEKV------KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQD 1448
              + +L+ + + ++K+      K +EI+ +   ++   +  + Q+  I EE    L    
Sbjct: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE----LRIAH 1780

Query: 1449 KHF-QHQATI------------------AELELEKTKLQELTRKLKERVTILVKQKDVLS 1489
             H  + Q TI                   +LE    KLQE  ++LK     L+  K  ++
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840

Query: 1490 HGEKE----EELKAMMHDLQITCSEMQ-------QKVELLRYESEKLQQENSILRNEITT 1538
              +K+    E+LK  + D  +T S+++       QK+     E + + +E   LR    T
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900

Query: 1539 LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1598
            L  E       L        E+ Q+ +T +  +   ++ V+ L+++ISE   K  Q+   
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE---KTIQISDI 1957

Query: 1599 NTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEEREQEKFNLKEE---LERCK 1654
              +L +   + Q+K+QEL ++  ++L  KE     +  + E EQ K   + +   ++  +
Sbjct: 1958 QKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017

Query: 1655 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ---LHRCPDLSDFQQKISSV 1711
            + +  L   L   L E++    IV +E    +DEL ++K+   + R   ++  ++ I+  
Sbjct: 2018 MDNFQLTKKLHESLEEIR----IVAKE----RDELRRIKESLKMERDQFIATLREMIARD 2069

Query: 1712 LSYNEKLLKEKEALSEE----LNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
               N ++  EK  LS+       S  +K ++   L  R + M    +     S  L+ ++
Sbjct: 2070 -RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128

Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE 1827
               +E    ++  +    LQ   ++      Q+       E   + K+L+     S+  +
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQR----CSMEFHRIMKKLKYV--LSYVTK 2182

Query: 1828 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE---------NERLQTMVQNTKAELTH 1878
            I       H    +   D +D +  +++ L+  +         +  L+ +  N   +L H
Sbjct: 2183 IKEEQ---HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL-H 2238

Query: 1879 SREKVRQLESNLLP----KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1934
              E ++    +  P    + Q+ L+    M    +E L+ + + ++ +      N ++ Q
Sbjct: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298

Query: 1935 MNSL--------------------------EQELETIHLENEGLKKKQVKLDEQLMEMQH 1968
            +N+                           EQ+L+++  +NE L K    L   L     
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ 2358

Query: 1969 LRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH-------LQEEL 2021
            +  T   + +PH              +  E+  +L+  L +A+    H       +Q+EL
Sbjct: 2359 VNPTTQDNKNPHV-------TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL 2411

Query: 2022 E----------NRTSETNTPQGNQEQLVTVMEERMI--------EVEQ-KLKLVKRLLQE 2062
            E           +  E+N      ++ + V+++++         E+E  K+KLVK  L E
Sbjct: 2412 EVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDL-E 2470

Query: 2063 KVNQLKE 2069
            K+   KE
Sbjct: 2471 KMKNAKE 2477



 Score =  194 bits (492), Expect = 1e-48
 Identities = 399/1970 (20%), Positives = 812/1970 (41%), Gaps = 407/1970 (20%)

Query: 383  DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 442
            + +  E   LR+D D        + +E ++    ++ +N+     LDE       AL+ +
Sbjct: 494  ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKND-----LDE-----FEALERK 543

Query: 443  LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 502
             +K++E          ++L  EI   K   N ++         N  LENEL    E L E
Sbjct: 544  TKKDQE----------MQLIHEISNLK---NLVKHAEVY----NQDLENELSSKVELLRE 586

Query: 503  YENLTNKLQ-----RNLENVLAEKFGDL----DPSSAEFFLQEERLTQMRNEYERQCRVL 553
             E+   KLQ     + LEN+  +    L    DP   +  L +     +  + +R+   L
Sbjct: 587  KEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL--DAKRESAFL 644

Query: 554  QDQVDELQSELEEYRAQGRVLR--LPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI 611
            + +  EL+ +++E     + +   + L  S  E  +     +E E      E   L   I
Sbjct: 645  RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI 704

Query: 612  EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE----NE 667
            + ++          +D+ C  LELE K+   +K+L+      K+ +EN   R E    +E
Sbjct: 705  DGKV---------PKDLLC-NLELEGKITDLQKELN------KEVEENEALREEVILLSE 748

Query: 668  THTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE----------- 716
              +L  ++  L+ EI +   +  ++     +       ++ ++Q  LEE           
Sbjct: 749  LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808

Query: 717  --------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT----- 757
                          +  H+  + + +  +E   R+ Q   +  +E +   SS        
Sbjct: 809  QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868

Query: 758  -------EEKVRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELL-EKHQRELQE--- 804
                   +EK R + + L +  Q  EQL +     TL+  E  K L+ EK Q+ L+E   
Sbjct: 869  SYKTQELQEKTREVQERLNEMEQLKEQLEN--RDSTLQTVEREKTLITEKLQQTLEEVKT 926

Query: 805  -GREKMETECNRRTSQIEA-QFQSDCQKVT-------ERCESALQSLEGRYRQELKDLQE 855
              +EK + +  + + QIE  Q +SD            E+  +AL+SL+ ++++ +  L+ 
Sbjct: 927  LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK-QHQETINTLKS 985

Query: 856  QQREEKSQWEFEKDELTQECAEAQELL-----KETLKREKTTSL--------VLTQEREM 902
            +  EE S+    ++   +   E Q+ +     K+ L+ + T +L        ++ Q+R++
Sbjct: 986  KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045

Query: 903  L-----EKTYKEHLNSMVVERQQLLQDL-EDLRNVSETQQS--LLSDQI---LELKSSHK 951
                  +   ++ L S++ E++QL  DL E++    E Q+   LL D++    E+ +  K
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105

Query: 952  RELREREEVLCQ-----AGASEQL--ASQRLERLE---MEHDQERQEMMSKLLAMENI-- 999
                ++E  L +     A   E+L   SQ+L+  +   +   +E  EM  K+  +EN+  
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165

Query: 1000 ----HKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE------EE 1049
                 + T E  + ER E++ +++    ++K + +    L  LQ   +   +       E
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225

Query: 1050 VEGDGALSLLQQGEQL------LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1103
            +E  G    LQ  E+L      L+E+ + +  L+R+  +   + +    ++ +   +LQ+
Sbjct: 1226 IEATG----LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN-TQDLEKSHTKLQE 1280

Query: 1104 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGS 1163
              P L           E   N  E +E    Q    ++E +T +    D          S
Sbjct: 1281 EIPVL-------HEEQELLPNVKEVSE---TQETMNELELLTEQSTTKD----------S 1320

Query: 1164 TGTSSVQRQEV----KIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
            T  + ++ + +    K +ES+  ++  ++  ++ +T  E+ E+K+   QL+E +    A 
Sbjct: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH--DQLKEHIRETLAK 1378

Query: 1220 CDRASEKKQDLL---------------------FDVSVLKKKLKML---ERIPEASPKYK 1255
               +  K++  L                      D ++L+ +++ML   +R+ E+  + K
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK 1438

Query: 1256 LLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELK--------KMEEVT 1307
                 V++E D LQ    ++++  D+  EN KE+ A+    ++ELK        + E + 
Sbjct: 1439 ----SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494

Query: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP-- 1365
            E  ++L +   E+    ++L  +  +LQ KI+++ E   Q     + E   +  E++   
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554

Query: 1366 -------------DGNILQLNQTLEECVPRVRSVHHVIEECK--------QENQYLEGNT 1404
                         +  +L+L   L+E    ++ +    EE K        + +Q  E   
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614

Query: 1405 QLLEKVKAH---------------------EIAWLHGTIQTHQ------ERPRVQNQVIL 1437
            +++ K+K                       EI  L    +T +      E   ++   IL
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674

Query: 1438 EENTTLLGFQDKHFQHQATIAE-LELEKTKLQE-----LTRKLKERVTILVKQKDVLSHG 1491
             EN   +    K      ++ E L++E+ +L+E     +TR L+++  + +    +  H 
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQ 1734

Query: 1492 EKEEELKAMMHDLQITCSEMQQKVE----LLRYESEKLQQENSI----LRNEITTLN--- 1540
            E  ++L+ ++ +     S MQ+ +E     L+ +  K+Q+E  I    L+ +  T++   
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR 1794

Query: 1541 -----EEDSISNLK--LGTLNGSQEEMWQKTE-------TVKQENAAVQKMV---ENLKK 1583
                 + D +SN++  L   N   +E  Q+ +       T+K++    QK V   E LKK
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQEL-----NQRLTEMLCQKEKEPGNSALEE 1638
            QI +  +   +L++EN  L+QK  +N E+++ +     N R  E   + E++    +L+E
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914

Query: 1639 REQEKFNLKEELERCKVQS---STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1695
             +     +++EL+  ++ S      V  L  ++SE  IQ   +Q++    KDEL+K    
Sbjct: 1915 TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK---- 1970

Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS 1755
                       KI  +     +LL+ KE +              ++   +I  M+Q +K 
Sbjct: 1971 -----------KIQELQKKELQLLRVKEDV--------------NMSHKKINEMEQLKKQ 2005

Query: 1756 WEHQSASLKSQLVASQEKVQNLEDTVQNVNL------QMSRMKSDLRVTQQEKEALKQEV 1809
            +E Q+ S++S  + + +  + L ++++ + +      ++ R+K  L++ + +  A  +E+
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 1810 MSLHKQLQNAGGKSWAPEIATHPSGLHN--QQKRLSWDKLDHLMNEEQQLLWQENERLQT 1867
            ++  +Q          PE      G  +  +  R    ++  L+    + +    E L  
Sbjct: 2066 IARDRQNHQV-----KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE-MDDHYECLNR 2119

Query: 1868 MVQNTKAELTHSREKVRQLESNL-LPKHQ-KHLNPSGTMNPTEQEKLSLKRECDQFQKEQ 1925
            +  + + E+   +E   ++++NL LP  Q KH+    T N         +R   +F +  
Sbjct: 2120 LSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTAN---------QRCSMEFHRIM 2170

Query: 1926 SPANRKVSQMNSL-EQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDL 1984
                  +S +  + E++ E+I+        +  K  E L+++QHL+      PS    DL
Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDC-DVPSRELRDL 2229

Query: 1985 QLLQ------QQACPMVPREQF----LQLQRQLLQAERINQHLQEELENRTSETNTPQGN 2034
            +L Q      ++        +F     + Q+ L   + + Q L+E L  R        G 
Sbjct: 2230 KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289

Query: 2035 QEQ--------------LVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
            Q++              ++ +M E   E E++   + +  ++ +  LKE+
Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNE-STEFEERSATISKEWEQDLKSLKEK 2338



 Score =  164 bits (414), Expect = 1e-39
 Identities = 356/1708 (20%), Positives = 715/1708 (41%), Gaps = 300/1708 (17%)

Query: 353  ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDL--------DKAEKLKS 404
            +NE++  +  I   +L   K E++ +LE    V+ EKE+L++DL        +  E+L+ 
Sbjct: 1035 DNEIIEQQRKIF--SLIQEKNELQQMLE---SVIAEKEQLKTDLKENIEMTIENQEELR- 1088

Query: 405  LMASEVDDHHAAIERRNEYNLRKLDEEYK--ERIAALKNELRKEREQILQQAGKQRLELE 462
            L+  E+      + +   + ++K  E  +  +R+A ++ +L KE+ Q LQ+  +Q L ++
Sbjct: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL-KEKSQQLQEKQQQLLNVQ 1147

Query: 463  QEIEKAKTEENYIRDRLALSLKENS----RLENELLENAEKLAE-YENLTNKLQRNLENV 517
            +E+ + + + N I + L   LK        +E E LE A+KL E YE + +  +      
Sbjct: 1148 EEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK 1206

Query: 518  LAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL-----QDQVDELQSELEEYRAQGR 572
              +K  + +      +++E   T ++ + E +   +     Q+ +DEL+  + E  AQ  
Sbjct: 1207 ELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ-- 1264

Query: 573  VLRLPLKNSPSEEVEANSGGIEPEHGL------GSEECNPLNMSIEAELVIEQMKEQHHR 626
            ++          +++     +  E  L       SE    +N   E EL+ EQ   +   
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN---ELELLTEQSTTKDST 1321

Query: 627  DICCLRLELEDKVRHYEK--QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 684
             +   R+E+E ++R  EK  +  E + S  K ++N+K   E     LE +   LK  I E
Sbjct: 1322 TLA--RIEME-RLRLNEKFQESQEEIKSLTKERDNLKTIKE----ALEVKHDQLKEHIRE 1374

Query: 685  LQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 744
               +    +    ++    E++ +  ++  E E+   ++   L+ E+E+     + Q S 
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434

Query: 745  EREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKE---LLEKHQ-- 799
            +  +   +     +     L  E +Q  +E +  +V KH   +EEL+     L E+ +  
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQL-KENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493

Query: 800  RELQEGREKMETECNRRTSQIEA---QFQSDCQKVTERCE-------------------- 836
             EL+    + ETE +    Q+EA   + Q+  Q++ E+ E                    
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF 1553

Query: 837  --------SALQSLEGRYRQELKDLQEQQRE------EKSQW-------EFEKDELTQEC 875
                    SALQS+E +  +    LQE Q E      EK +        + E+D+L +  
Sbjct: 1554 KEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613

Query: 876  AEAQELLKETLKRE----KTTSLVLTQER----EMLEK---TYKEHLNSMVVERQQLLQ- 923
             E    +KE+ ++E    K T++  TQE+    E L++   T K +L ++  E  +L Q 
Sbjct: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673

Query: 924  ---DLEDLRNVSETQQSLLS---------DQILE-LKSSHKRELREREEVLCQAGASEQL 970
               +LE++R+V++ +  L S         DQ+ E L+ +  R+L ++EE+        ++
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL--------KI 1725

Query: 971  ASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAE---MSTEISRLQSKIKE 1027
                L+  +   D+ R  +  K   + N+ K    + D  +A+   +  E+      +KE
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785

Query: 1028 MQQATSPL-SMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE 1086
             Q+    L  ++      +   + + + + + LQ+  Q L+ N   L++L++     V E
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD----VNE 1841

Query: 1087 NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGV 1144
              K  +E+ +L+++++  +  L +S    E       N A++    L++ ++  K+ + +
Sbjct: 1842 TQKKVSEMEQLKKQIK--DQSLTLSKLEIENL-----NLAQKLHENLEEMKSVMKERDNL 1894

Query: 1145 TRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKN 1204
             R      LE D++++           QE K  + E   E  +    S+E +    +L+ 
Sbjct: 1895 RRVEETLKLERDQLKE---------SLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945

Query: 1205 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE 1264
            +IS+   Q+  +  D D++ ++ Q  + ++   KK+L++L    + +  +K + E    +
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQ--KKELQLLRVKEDVNMSHKKINEMEQLK 2003

Query: 1265 NDCLQEELRMMETRYD-----EALENNKELTAEVFRLQDELKKMEE-----------VTE 1308
                 + L M   R D     + L  + E    V + +DEL++++E              
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLR 2063

Query: 1309 TFLSLEKSYDEVKIENEELNV----LVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIE 1364
              ++ ++   +VK E   L+     L   L+ K  +++E + +  +       L  L ++
Sbjct: 2064 EMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD 2123

Query: 1365 PDGNI-----LQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLH 1419
             +  I     L +       +P +++ H  IE+    NQ        + K   + ++++ 
Sbjct: 2124 LEKEIEFQKELSMRVKANLSLPYLQTKH--IEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181

Query: 1420 GTIQT-HQERPRVQNQVILE-ENTTLLGFQDKHFQHQATIAELELEKTKL--------QE 1469
               +  H+   + +   I E E    L  + +H Q    +   EL   KL        +E
Sbjct: 2182 KIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEE 2241

Query: 1470 LTRKLKERV--TILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527
            + +   E    +I  + + VLS+    +E+   + +   T  ++++    ++ E++++ Q
Sbjct: 2242 ILKDFSESEFPSIKTEFQQVLSN---RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI-S 1586
             N+   N I  +  E +    +  T++   +E  Q  +++K++N  + K  + LK  + S
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATIS---KEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355

Query: 1587 ELKIKNQQLDLENTELSQKNSQ-NQEKLQELNQRLTE------------MLCQKEKE--- 1630
              ++     D +N  ++ + +Q   EK++EL   L E            +  QKE E   
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415

Query: 1631 -----------PGNSALEERE------QEKFNL-----KEELERCKVQSSTL-------V 1661
                         N  LE+ +      Q+K  L     KEE+E  K++   +        
Sbjct: 2416 DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA 2475

Query: 1662 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL--------HRCPDLSD---------- 1703
               E E+S  K      ++   LL++ L + +Q         H  P  S+          
Sbjct: 2476 KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSG 2535

Query: 1704 ----------------FQQKISSVLSYNEKLLKEK-------EALSEELNSCVDKLAKSS 1740
                             +++IS +   NE+L+K+K       + LS E+ +  ++  K  
Sbjct: 2536 IVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595

Query: 1741 LLEHRIATMKQEQKSWE-HQSASLKSQLVASQEKVQNLEDTVQNVNLQM----SRMKSDL 1795
               H+  T +   KS +   +AS K Q+  SQ K +NL+D V   + +     SR KS  
Sbjct: 2596 --AHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKS-- 2651

Query: 1796 RVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
              +           + L  ++QNAG +S
Sbjct: 2652 LPSPHPVRYFDNSSLGLCPEVQNAGAES 2679



 Score =  139 bits (350), Expect = 3e-32
 Identities = 295/1382 (21%), Positives = 578/1382 (41%), Gaps = 222/1382 (16%)

Query: 840  QSLEGRYRQELKDLQEQQRE---EKSQWEFEKDELTQECAEAQELLK-ETLKREKTTSLV 895
            ++L  RYR+E+ DL++Q  E   E      EKD+L Q   E   L K +  K E  T ++
Sbjct: 342  EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401

Query: 896  LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE-- 953
            +T     L++  K      V      L  +  ++N +   Q  +   I     +HK    
Sbjct: 402  VTSSSLTLQQELKAKRKRRVT---WCLGKINKMKNSNYADQFNIPTNI--TTKTHKLSIN 456

Query: 954  -LREREEVLCQAGASEQLASQRLERL-EMEHDQERQEMMSKLLAMENIH------KATCE 1005
             LRE +E +C   +   + S  L+ L E+E +       +KLL  ENI       +A  +
Sbjct: 457  LLREIDESVC---SESDVFSNTLDTLSEIEWNP-----ATKLLNQENIESELNSLRADYD 508

Query: 1006 TADRERAEMSTEISRLQSKIKEMQ-----QATSPLSMLQSGCQVIGE----------EEV 1050
                +  ++ TE   ++ K+KE       +A    +      Q+I E           EV
Sbjct: 509  NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEV 568

Query: 1051 EGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS--------RLQQRL- 1101
                  + L    +LL E  D +  LQ   +    EN+KM    S        +++Q L 
Sbjct: 569  YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLF 628

Query: 1102 --------QKLEPGLVMSSCLD-EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSD 1152
                     K E   + S  L+ +   +    T +Q E  +Q  ++ Q+E   +  V  D
Sbjct: 629  DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS-QLEAKKKMQV--D 685

Query: 1153 LEDD------EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI 1206
            LE +      E+  L S     V +  +   E E  +    +  N E    E+  L+ ++
Sbjct: 686  LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA--LREEV 743

Query: 1207 SQLQEQLMMLCADCDRASEKKQDLLFDVSVL-KKKLKMLERIPEASPKYKLLYEDVSREN 1265
              L E L  L ++ +R  ++ QD   ++ ++  +K K+   +     + + L E++ +  
Sbjct: 744  ILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802

Query: 1266 DCLQ----------------EELRM-METRYDEALENNKELTAEVFRLQDELKKMEEVTE 1308
            D L                 + L M  E +Y   LE N+ +  E+  L  E +K +    
Sbjct: 803  DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS--- 859

Query: 1309 TFLSLEKSYDEVKIENEELNVLVLRLQ---GKIEKLQESVVQRCDCCLWEASLENLEIEP 1365
               SL     E+  + +EL      +Q    ++E+L+E +  R      +++L+ +E E 
Sbjct: 860  ---SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR------DSTLQTVEREK 910

Query: 1366 DGNILQLNQTLEECVPRVRSVHHVIEECKQ-------------------ENQYLEGNTQL 1406
                 +L QTLEE    V+++    ++ KQ                    N  ++   QL
Sbjct: 911  TLITEKLQQTLEE----VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL 966

Query: 1407 ---LEKVKAHEIAWLHGTIQTHQER--PRVQNQVILEENTTLLGFQDKHFQHQ--ATIAE 1459
               LE +K H+      TI T + +    V   + +EENT   G     FQ +      +
Sbjct: 967  RNALESLKQHQ-----ETINTLKSKISEEVSRNLHMEENT---GETKDEFQQKMVGIDKK 1018

Query: 1460 LELEKTKLQELTRKLKE--------RVTILVKQKDVLSH------GEKEEELKAMMHDLQ 1505
             +LE    Q LT  +K+        ++  L+++K+ L         EKE+    +  +++
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 1506 ITCSEMQQKVELLRYESEK-----LQQENSILRNEITTLNEEDSISNL--KLGTLNGSQE 1558
            +T  E Q+++ LL  E +K      Q++N  ++ E       D ++ +  KL   +   +
Sbjct: 1079 MTI-ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 1559 EMWQKTETVKQENAAVQKM---VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQE 1615
            E  Q+   V++E + +QK    +ENLK ++   ++  + ++ E  EL+QK ++N E+++ 
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197

Query: 1616 LNQ-----RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV---QSSTLVSSLEAE 1667
            + +     +  +   + E++     + E E      KEEL+   +   +    +  L   
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS 1257

Query: 1668 LSEVK---IQTHIVQQENHLLKDEL----EKMKQLHRCPDLSDFQQKISSVLSYNEKLLK 1720
            +SE     I T  +++ +  L++E+    E+ + L    ++S+ Q+ ++ +     +LL 
Sbjct: 1258 VSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL-----ELLT 1312

Query: 1721 EKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDT 1780
            E+    +       ++ +  L E +    ++E KS   +  +LK+   A + K   L++ 
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNE-KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371

Query: 1781 VQN--VNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEI-----ATHPS 1833
            ++     +Q S+ K +  +  +EK+    +++S  +Q +         EI     +    
Sbjct: 1372 IRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ 1431

Query: 1834 GLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPK 1893
              H++ K ++ +K D  +   Q++L  E+++L+  ++   A+   + E+++     L  K
Sbjct: 1432 ESHDEMKSVAKEKDD--LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL--K 1487

Query: 1894 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK 1953
             Q+       +N +E+E      E    QK+    N K      L+ +++ I+ + E   
Sbjct: 1488 EQEETINELRVNLSEKE-----TEISTIQKQLEAINDK------LQNKIQEIYEKEEQFN 1536

Query: 1954 KKQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2012
             KQ+ ++ E++ E++  +       S     LQ ++ +   +  R Q  Q + Q++  E+
Sbjct: 1537 IKQISEVQEKVNELKQFKEHRKAKDSA----LQSIESKMLELTNRLQESQEEIQIMIKEK 1592

Query: 2013 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVK-RLLQEK---VNQLK 2068
              + ++   E    E +  + N +++V  M+E   +  Q LK+      QEK   +  LK
Sbjct: 1593 --EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLK 1650

Query: 2069 EQ 2070
            EQ
Sbjct: 1651 EQ 1652



 Score =  134 bits (337), Expect = 9e-31
 Identities = 298/1488 (20%), Positives = 615/1488 (41%), Gaps = 207/1488 (13%)

Query: 270  LKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQ 329
            LK H   ++ DE  R  +  +A       ++ +  D    H  ++  +    EE     Q
Sbjct: 1244 LKEH--QETIDELRRSVSEKTA-------QIINTQDLEKSHTKLQEEIPVLHEE-----Q 1289

Query: 330  EILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 389
            E+L  +    +    + EL L  E     TK+S     LA  + E   L E+  +   E 
Sbjct: 1290 ELLPNVKEVSETQETMNELELLTEQS--TTKDS---TTLARIEMERLRLNEKFQESQEEI 1344

Query: 390  EKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQ 449
            + L  + D  + +K  +  + D               +L E  +E +A ++    K+ + 
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHD---------------QLKEHIRETLAKIQESQSKQEQS 1389

Query: 450  I-LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTN 508
            + +++   +  ++  E+E+ K +++ +  R+ + +   S+   E  +  + +A+ ++   
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALL-RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ 1448

Query: 509  KLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR---NEYERQCRVLQDQVDELQSELE 565
            +LQ  L++   +   ++    A+    EE L        E E     L+  + E ++E+ 
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508

Query: 566  EYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 625
              + Q   +   L+N   E  E              E+ N   +S   E V E  + + H
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKE------------EQFNIKQISEVQEKVNELKQFKEH 1556

Query: 626  RDICCLRLE-LEDKVRHYEKQLDETVVSCK---KAQENMKQRHENETHTLEKQISDLKNE 681
            R      L+ +E K+     +L E+    +   K +E MK+  E     L+ +   LK  
Sbjct: 1557 RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE----ALQIERDQLKEN 1612

Query: 682  IAELQGQAAVLKEAHHE---ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 738
              E+  +    +E  ++    T  +E ++K  +++  +E+   Q KL L++      RLT
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLT 1671

Query: 739  QA-------QASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELR 791
            Q          S  +ER+ L+S    EE ++    +L++  +E +T  +EK    +EEL+
Sbjct: 1672 QILHENLEEMRSVTKERDDLRS---VEETLKVERDQLKENLRETITRDLEK----QEELK 1724

Query: 792  KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELK 851
              ++  H +E QE  +K+    + +T++I     S+ QK  E    AL++ + + ++EL+
Sbjct: 1725 --IVHMHLKEHQETIDKLRGIVSEKTNEI-----SNMQKDLEHSNDALKAQDLKIQEELR 1777

Query: 852  ----DLQEQQR----------EEKSQWEFEKDELTQECAEAQELLKE---------TLKR 888
                 L+EQQ           E+  +    + +L    A+ QE ++E         TLK+
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837

Query: 889  EKTTSLVLTQEREMLEKTYKEH---LNSMVVER----QQLLQDLEDLRNVSETQQSLLSD 941
            +   +     E E L+K  K+    L+ + +E     Q+L ++LE++++V + +     D
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER-----D 1892

Query: 942  QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM---EH----DQERQEMMSKLL 994
             +  ++ + K E  + +E L +  A +    Q L+   M   EH    D+ R+++  K +
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952

Query: 995  AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML------------QSGC 1042
             + +I K      D+ + E+  +I  LQ K  ++ +    ++M             Q   
Sbjct: 1953 QISDIQK----DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008

Query: 1043 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQR 1100
            Q +  + V  D    L ++  + LEE    +++ +R   + +KE++KM  +  I+ L++ 
Sbjct: 2009 QNLSMQSVRMDN-FQLTKKLHESLEEIR--IVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 1101 LQK------LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE 1154
            + +      ++P   + S   +  TE       + +  L++             +  DLE
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125

Query: 1155 DD-------EVRDLGSTGTSSVQRQEVK---IEESEASVEGFSELENSEETRTESWELKN 1204
             +        +R   +     +Q + ++         S+E    ++  +   +   ++K 
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185

Query: 1205 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIP---EASPKYKLLYEDV 1261
            +  +   +  M   D     EK+++LL  +  L++   +  R     + +    L  E++
Sbjct: 2186 EQHESINKFEMDFID---EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242

Query: 1262 SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1321
             +  D  + E   ++T + + L N KE+T     L++ L    ++ +    ++K  D + 
Sbjct: 2243 LK--DFSESEFPSIKTEFQQVLSNRKEMTQF---LEEWLNTRFDIEKLKNGIQKENDRIC 2297

Query: 1322 IENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVP 1381
              N   N  ++ +  +  + +E          WE  L++L+ E +  + +  QTL+  + 
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISK--EWEQDLKSLK-EKNEKLFKNYQTLKTSLA 2354

Query: 1382 RVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQT--HQERPRVQNQVILEE 1439
                V+   ++ K  +          EK++  E + LH   ++  H+E   ++ Q  LE 
Sbjct: 2355 SGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENS-LHEAKESAMHKESKIIKMQKELEV 2413

Query: 1440 NTTLLGFQDKHFQHQATIAELE--LEKTK--LQELTRKL-------KERVTILVKQKDVL 1488
               ++       + QA + E    LEKTK  +Q L  K+       KE +  L K K V 
Sbjct: 2414 TNDIIA------KLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL-KMKLVK 2466

Query: 1489 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1548
               EK +  K    ++  T + ++ + E++R   E L++        + + + +   SN 
Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526

Query: 1549 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1608
             L    GS      K   +K E+         L+K+IS+LK +N+QL  +  EL   N  
Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEHI-------RLEKEISKLKQQNEQLIKQKNELLSNNQH 2579

Query: 1609 NQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL--ERCK 1654
               +++   +R  +    K+    NS    +     + K+++   +CK
Sbjct: 2580 LSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCK 2627



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 148/717 (20%), Positives = 296/717 (41%), Gaps = 107/717 (14%)

Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
            +LEE   L   Q++  ++   +       T  QEL  K K RVT  + + + + +    +
Sbjct: 379  LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD 438

Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-------------- 1541
            +     +   IT    +  + LLR   E +  E+ +  N + TL+E              
Sbjct: 439  QFNIPTN---ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQEN 495

Query: 1542 -EDSISNLKLG---------TLNGSQEEMWQKTE--------------TVKQENAAVQKM 1577
             E  +++L+            L   +EEM  K +              T K +   +   
Sbjct: 496  IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHE 555

Query: 1578 VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE 1637
            + NLK  +   ++ NQ  DLEN ELS K    +EK  ++ ++L E +        +  LE
Sbjct: 556  ISNLKNLVKHAEVYNQ--DLEN-ELSSKVELLREKEDQI-KKLQEYI-------DSQKLE 604

Query: 1638 EREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM----K 1693
              + +     E +E  K    TL  + E    + K ++  ++ EN  LK++++++    K
Sbjct: 605  NIKMDLSYSLESIEDPKQMKQTLFDA-ETVALDAKRESAFLRSENLELKEKMKELATTYK 663

Query: 1694 QLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEE---LNSCVD-KLAKSSL----LEHR 1745
            Q+    D+  +Q ++ +       L KE ++   E   L S +D K+ K  L    LE +
Sbjct: 664  QMEN--DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 721

Query: 1746 IATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL 1805
            I  +++E      ++ +L+ +++   E +++L   V+ +  ++     +L +   EK+ L
Sbjct: 722  ITDLQKELNKEVEENEALREEVILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKL 780

Query: 1806 KQEVMSLHKQLQNAG-----GKSWAPEIATHPSGLHNQQKRLSWDKLDHL-MNEEQQLLW 1859
              EV  +HK+ +  G     GK+   ++AT  S   +  +     K  H+   ++ +++ 
Sbjct: 781  FSEV--VHKESRVQGLLEEIGKT-KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837

Query: 1860 QENERLQTMVQN--------------TKAELTHS----REKVRQLESNLLPKHQ---KHL 1898
            +ENER+   + N               K EL++     +EK R+++  L    Q   +  
Sbjct: 838  EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897

Query: 1899 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1958
            N   T+   E+EK  +  +  Q  +E         + + L+Q  E++ +E + LK     
Sbjct: 898  NRDSTLQTVEREKTLITEKLQQTLEE---VKTLTQEKDDLKQLQESLQIERDQLKSDIHD 954

Query: 1959 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ----RQLLQAERIN 2014
                 ++ Q     A  S   H   +  L+ +    V R   ++      +   Q + + 
Sbjct: 955  TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG 1014

Query: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
               +++LE + ++T T      +++    +    +++K +L + L  E V   KEQ+
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQML--ESVIAEKEQL 1069



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 101/532 (18%), Positives = 207/532 (38%), Gaps = 60/532 (11%)

Query: 1550 LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQN 1609
            L  L  +    + K      E +  + +++  +K+I +LK + +++ LE    + +  Q 
Sbjct: 317  LTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL 376

Query: 1610 QEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELS 1669
             + L+E                    L++ + EK    E L R  V SS+L    E +  
Sbjct: 377  AQLLEE-----------------KDLLQKVQNEKI---ENLTRMLVTSSSLTLQQELKAK 416

Query: 1670 EVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL 1729
              +  T  + + N +          +         +  I+ +   +E +  E +  S  L
Sbjct: 417  RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTL 476

Query: 1730 NSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS 1789
            ++        S +E   AT    Q++ E +  SL++         + L    + + L++ 
Sbjct: 477  DTL-------SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL- 528

Query: 1790 RMKSDL-RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD 1848
            + K+DL      E++  K + M L  ++ N   K+       +   L N+       K++
Sbjct: 529  KEKNDLDEFEALERKTKKDQEMQLIHEISNL--KNLVKHAEVYNQDLENELS----SKVE 582

Query: 1849 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTE 1908
             L  +E Q+   +       ++N K +L++S E +        PK  K      T+   E
Sbjct: 583  LLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED------PKQMKQ-----TLFDAE 631

Query: 1909 QEKLSLKRECDQFQKEQSPANRKVSQM----NSLEQELETIHLENEGLKKKQVKLDEQLM 1964
               L  KRE    + E      K+ ++      +E +++    + E  KK QV L+++L 
Sbjct: 632  TVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQ 691

Query: 1965 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE---L 2021
               +  +  T        D ++ +   C +    +   LQ++L +    N+ L+EE   L
Sbjct: 692  SAFNEITKLT-----SLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746

Query: 2022 ENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL--QEKVNQLKEQV 2071
                S  +  +  ++++    EE  I   +K KL   ++  + +V  L E++
Sbjct: 747  SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 970  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2443

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2444 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2482

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2483 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2531

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2532 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2557

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2686 EDVR 2689



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 968  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2271

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2325


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1067 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1124

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1125 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1178

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1239 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1290

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1333

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1334 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1382

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1383 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1443 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1560

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1679

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1738

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1843

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1844 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2377

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2431

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1406

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1462

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1521

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1581

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1881

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1882 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2120

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2179

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2180 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2224

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2225 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2283

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2284 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2334

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2335 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2381

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2382 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2436

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2493

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2604

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2605 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2665 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2713



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 974  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1032

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1092

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1093 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1153 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1389 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1507 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1560

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1857

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1914

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1975 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2032

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2447

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2448 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2486

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2487 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2535

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2536 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2561

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2604



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1957 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2070

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2122

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2176

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2177 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2220

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2279

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2338

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2339 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2455 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2495

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2496 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2553

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2554 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2585

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2586 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2634

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2635 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2689

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2690 EDVR 2693



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 972  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1029

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1030 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1085

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1146 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1188

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1189 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1358

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1416

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1417 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1467

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1527

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1702

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1819

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1820 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1927

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1928 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2041

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2218

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2219 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2275

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2276 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2329


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1063 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1121 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1174

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1235 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1286

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1329

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1330 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1439 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1556

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1675

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1734

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1839

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1840 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2373

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2427

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1458

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2116

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2175

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2176 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2280 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2330

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2331 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2377

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2378 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2432

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2489

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2600

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2709



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 970  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1028

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1149 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1385 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1503 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1556

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1853

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1910

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1971 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2028

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2443

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2444 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2482

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2483 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2531

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2532 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2557

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1953 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2066

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2118

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2172

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2173 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2216

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2334

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2335 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2451 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2491

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2550 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2581

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2582 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2630

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2631 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2686 EDVR 2689



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 968  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1081

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1142 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1184

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1185 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1354

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1412

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1413 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1463

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1698

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1815

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1816 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1923

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1924 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2037

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2214

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2215 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2271

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2325


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1031 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1088

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1089 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1142

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1203 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1254

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1297

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1298 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1346

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1347 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1407 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1524

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1643

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1702

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1807

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1808 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2341

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2395

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1370

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1426

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1485

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1545

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1845

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1846 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2084

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2143

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2144 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2188

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2189 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2247

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2248 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2298

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2299 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2345

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2346 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2400

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2457

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2568

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2569 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2629 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2677



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 938  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 996

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 997  AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1056

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1057 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1117 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1353 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1471 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1524

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1821

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1878

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1939 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 1996

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2411

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2412 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2450

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2451 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2499

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2500 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2525

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2568



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1921 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2034

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2086

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2140

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2141 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2184

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2243

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2302

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2303 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2419 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2459

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2460 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2517

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2518 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2549

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2550 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2598

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2599 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2653

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2654 EDVR 2657



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 936  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 993

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 994  QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1049

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1110 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1152

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1153 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1322

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1380

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1381 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1431

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1491

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1666

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1783

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1784 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1891

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1892 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2005

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2182

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2183 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2239

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2240 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2293


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1200 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1257

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1258 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1311

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1372 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1423

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1466

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1467 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1515

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1516 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1576 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1693

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1812

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1871

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1976

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1977 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2510

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2564

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1539

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1595

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1654

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1714

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 2014

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 2015 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2253

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2312

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2313 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2357

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2358 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2416

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2417 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2467

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2468 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2514

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2515 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2569

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2626

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2737

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2738 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2798 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2846



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 1107 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1165

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1225

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1226 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1286 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1522 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1640 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1693

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1990

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 2047

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 2108 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2165

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2580

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2581 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2619

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2620 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2668

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2669 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2694

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2737



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 2090 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2203

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2255

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2309

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2310 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2353

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2412

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2471

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2472 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2588 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2628

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2629 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2686

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2687 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2718

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2719 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2767

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2768 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2822

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2823 EDVR 2826



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 1105 LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1162

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1218

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1279 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1321

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1322 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1491

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1549

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1550 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1600

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1660

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1835

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1952

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1953 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 2060

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 2061 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2174

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2351

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2352 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2408

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2409 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2462


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1041 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1098

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1099 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1152

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1213 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1264

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1307

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1308 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1356

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1357 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1417 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1475

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1476 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1534

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1653

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1712

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1817

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1818 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2351

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2405

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1380

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1436

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1495

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1555

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1855

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1856 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2094

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2153

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2154 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2198

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2199 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2257

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2258 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2308

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2309 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2355

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2356 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2410

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2467

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2578

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2579 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2639 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2687



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 948  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1006

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1066

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1067 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1127 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1363 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1481 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1534

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1831

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1888

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1949 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2006

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2421

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2422 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2460

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2461 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2509

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2510 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2535

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2578



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1931 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2044

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2096

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2150

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2151 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2194

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2253

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2312

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2313 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2429 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2469

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2470 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2527

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2528 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2559

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2560 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2608

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2609 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2663

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2664 EDVR 2667



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 946  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1003

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1059

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1120 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1162

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1163 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1332

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1390

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1391 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1441

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1501

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1676

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1793

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1794 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1901

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1902 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1960 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2015

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2192

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2193 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2249

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2250 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2303


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1049 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1106

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1107 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1160

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1221 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1272

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1315

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1316 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1364

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1365 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1425 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1483

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1484 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1542

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1661

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1720

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1825

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1826 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2359

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2413

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1388

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1444

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1503

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1563

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1863

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1864 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2102

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2161

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2162 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2206

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2207 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2265

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2266 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2316

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2317 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2363

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2364 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2418

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2475

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2586

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2587 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2647 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2695



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 956  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1014

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1074

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1075 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1135 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1371 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1489 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1542

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1839

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1896

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1957 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2014

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2429

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2430 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2468

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2469 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2517

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2518 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2543

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2586



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1879 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1939 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2052

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2104

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2158

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2159 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2202

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2261

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2320

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2321 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2437 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2477

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2478 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2535

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2536 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2567

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2568 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2616

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2617 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2671

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2672 EDVR 2675



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 954  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1011

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1012 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1067

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1068 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1128 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1170

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1171 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1340

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1398

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1399 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1449

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1509

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1629

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1684

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1801

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1802 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1909

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1910 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 1968 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2023

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2200

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2201 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2257

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2258 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2311


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  176 bits (446), Expect = 2e-43
 Identities = 328/1618 (20%), Positives = 664/1618 (41%), Gaps = 233/1618 (14%)

Query: 352  LENELLVTKNSIHQAALASFKAEIRHLLERVDQVVR----EKEKLRSDLDKAEKLKSLMA 407
            L +EL +T   + Q  + S  A     L+ +  V+R     +E LR+  ++ ++ +++ A
Sbjct: 1090 LRSELELTLGKLEQ--VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1147

Query: 408  S--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 465
            +  E++   A++++     LR   E  +    AL++ELR  +E + ++  ++  E + E+
Sbjct: 1148 TLPELEATKASLKK-----LRAQAEAQQPTFDALRDELRGAQE-VGERLQQRHGERDVEV 1201

Query: 466  EKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL-------QRNLENVL 518
            E+ +     + +R    L +    + EL +   +L  Y    + L       +R  E + 
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261

Query: 519  AEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            A    D   +  E   QE+ L +   E ER      ++V+E Q   ++Y    +   L L
Sbjct: 1262 AMPLAD-SQAVREQLRQEQALLE---EIERH----GEKVEECQRFAKQYINAIKDYELQL 1313

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
                ++     S   +P+   GSE             VI     Q + D+     EL   
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSES------------VI-----QEYVDLRTHYSELTTL 1356

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQG---QAAVLKEA 695
               Y K + ET+           +R E E    E+Q ++ +  +AE++    +   L EA
Sbjct: 1357 TSQYIKFISETL-----------RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA 1405

Query: 696  HHEATCRHEEEKKQLQVKLEEE--------------KTHLQEKL---RLQHEMELKARLT 738
            H +A  + E E K+LQ +++EE              K  +QE+L   R   E E++A+  
Sbjct: 1406 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465

Query: 739  QAQASFEREREGLQSSAW--------TEEKVRGLTQELEQFHQEQLTSLVEKHTL--EKE 788
            QA+A+ ER R  ++            TE +  G   EL+        +  +K     E E
Sbjct: 1466 QAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1524

Query: 789  ELRKELLEKHQRELQE-----GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 843
             LR+++ ++ QR+ Q       R K E E  R   Q   Q   + +   E  E  L+  E
Sbjct: 1525 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQAEEAERRLRQAE 1583

Query: 844  -GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET------LKREKTTSLVL 896
              R RQ    L+  QR  +++ + ++    ++ A+ +  L+E       L+ E       
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 897  TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 956
              E E   +  +  L    ++  + L+       V++ Q+SL   +  + K   +RE R 
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARR 1702

Query: 957  REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
            R +   QA    +LA Q LE+     +   Q+ ++    +  + +A  E  +++R  +  
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL-RAETEQGEQQRQLLEE 1761

Query: 1017 EISRLQSKI----KEMQQATSPLSMLQSGCQVIGEEEVEGDG-ALSLLQQGEQLLEENGD 1071
            E++RLQ +     ++ Q+  + L+ +++  +V+   +   +  + S  ++ +Q LE    
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821

Query: 1072 VLLSL--QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQT 1129
                L  + A  +A+ E  K   +++      Q+ E   V+               AE+ 
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL---------------AEKL 1866

Query: 1130 EPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG-FSE 1188
                +  R K    +  +    + E++ +R L        +R E +  + +A +E   ++
Sbjct: 1867 AAIGEATRLKTEAEIALKE--KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924

Query: 1189 LENSEETRTESW-----ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKK--- 1240
            L  + ++  E       +   Q  Q++E+++ L A  ++A+  K +L  ++  ++     
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984

Query: 1241 -LKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ-- 1297
             L+  E+    + + + L  +  R     +E ++      +EA    K    EV RL+  
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044

Query: 1298 -DELKKMEEVTETF----LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR---C 1349
             +E +++ E  E      L L +   + +++ EE       +Q K ++LQ+++ Q     
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 1350 DCCLWEASL--------ENLEIEPDGNILQ----------LNQTLEECVPRVRSVHHVIE 1391
            D    EA          E   ++ +    Q          L Q+ EE            E
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE--RPRVQNQVILEENTTLLGFQDK 1449
            + ++E +         E+    +       ++ H++     ++ +  +E+  T L  Q +
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223

Query: 1450 HFQHQATIAELELEKTKLQ----------------------ELTRKLKERV-----TILV 1482
               HQ  + + EL++ K +                      E   KLK R+      +++
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283

Query: 1483 KQKDVLSH--GEKEEELKAMMHD---LQITCSEM------------QQKVELLRYESEKL 1525
            + KD       E+ E++K +  +   L +   E             QQ+    +   EK+
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343

Query: 1526 Q--QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            Q  QE + L+ E   L ++  ++  +   L   +E+M Q+   + +E    Q+ +E  ++
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQ 2400

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
            +  E+  + ++L L   E+S+  ++ +E  Q   ++  E+  +  +       E   QEK
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT------ELATQEK 2454

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSD 1703
              L + LE  + QS      L   ++E++ +   +QQE  LL+ + E+M+ + +   L +
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA---TMKQEQKSWEHQS 1760
             Q    S LS  + LL+ +  + +E      K     L +  +A    +++EQ+  + Q 
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQE------KAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568

Query: 1761 ASLKSQLVASQEKVQNLE-DTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
               + +LVAS E+ +  + +  + V  +   ++   +  +Q++E L +E   L +QLQ
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626



 Score =  174 bits (440), Expect = 1e-42
 Identities = 313/1489 (21%), Positives = 621/1489 (41%), Gaps = 214/1489 (14%)

Query: 384  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 443
            Q+V  K +L      A+K K    SE         R +   L  L  +Y + I+     +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371

Query: 444  RKEREQILQQAGKQR---------LELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
             +E     QQ  ++R         LE ++++ +A  +     +R A  L++  R++ E++
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1429

Query: 495  ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ 554
               E   + +     +Q  L+ +      ++   +     Q E   + R   E + RV++
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR----QAEAAERSRLRIEEEIRVVR 1485

Query: 555  DQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             Q++  +        EL+  RA+        K    EE E     ++ E     +    L
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVEL 1544

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEK----QLDETVVSCKKAQENMKQR 663
               ++AE    + K++  + +  LRL+ E+  R   +    +  +  V+ + AQ + +  
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1604

Query: 664  HENETHTLEKQISDLKNEIAELQGQAAVLKE-AHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
             +++  +  ++ + L+  + E     A L+E A   A  + E E+ + + + E E+  L+
Sbjct: 1605 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664

Query: 723  E----KLRLQ-HEMELKARLTQAQASFERE---REGLQSSAWTEEKVRG---LTQELEQF 771
                 +LRLQ  E+  +  L QA+A  ++E   RE  +     E+ VR      QELE+ 
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724

Query: 772  HQEQLTSLVEKHTLEKEELR-----------KELLEKHQRELQ-------EGREKMETEC 813
             Q    +  ++   E+E +R           ++LLE+    LQ       + R+++E E 
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784

Query: 814  NRRTSQIE------AQFQSDCQKVTERCESALQSLEGRYRQ---ELKDLQEQQREEKSQW 864
             +  +++E      A+ + + +  +E+ +  L++  GR+R+   E   L+    E K Q 
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844

Query: 865  EFEKDELTQECAEAQELLKETLK------REKTTSLVLTQEREMLEKTYKEHLNSMVVER 918
            +  +++  ++ AEA+ +L E L       R KT + +  +E+E   +  +        +R
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1904

Query: 919  QQLLQ-------DLED----LRNVS----ETQQSLLSD----------QILELKSSHKRE 953
            ++L +       D+E+    LR  S    E Q+ L+ D          +IL LK+S ++ 
Sbjct: 1905 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964

Query: 954  LREREEVLCQAGASEQLASQRL---ERLEMEHDQERQ----EMMSKLLAMENIHKATC-- 1004
               + E+  + G     A   L   E+ E+E  ++RQ    E   +  A E + K+    
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024

Query: 1005 ETADRERAEMSTEISRLQSKIKEM--------QQATSPLSMLQSGCQ--VIGEEEVEGDG 1054
            E A R+R     E+ RL++K++E         Q++   L + Q   Q  +  EE+     
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084

Query: 1055 ALSLLQQGEQLLEENGDVLLSLQ-------RAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
                 Q+ +Q L++   VL  L+       RA E+A +  V+   E ++ ++++++ E  
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER- 2143

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQN---RTKQVEGVTRRHVLSDLEDDEVRDLGST 1164
            L  S+     A       AE+     +Q    R +  +   R+   +D E ++ +     
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE- 2202

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
                  RQ+ ++E+   ++            R +  E  +Q + L E+L  L A+   A+
Sbjct: 2203 ---QTLRQKAQVEQELTTL------------RLQLEETDHQKNLLDEELQRLKAEATEAA 2247

Query: 1225 EKKQDL---LFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
             ++  +   LF V V  ++L  L+   EA  +  L+  D       LQEE   M+   +E
Sbjct: 2248 RQRSQVEEELFSVRVQMEELSKLKARIEAENR-ALILRDKDNTQRFLQEEAEKMKQVAEE 2306

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIE 1339
            A        A +     E  ++ ++ E  L+ +++  E K+  E++  +    RL+ + E
Sbjct: 2307 A--------ARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAE 2357

Query: 1340 KLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
             LQ+         L +     L+ + +    Q+ Q L E     +     +E  +Q    
Sbjct: 2358 LLQQQKE------LAQEQARRLQEDKE----QMAQQLAE---ETQGFQRTLEAERQRQLE 2404

Query: 1400 LEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE-NTTLLGFQDKHFQHQATIA 1458
            +    + L K++  E++      +   +R R Q + I E+ + T L  Q+K       + 
Sbjct: 2405 MSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK----VTLVQ 2459

Query: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
             LE+++ +      +L+E +  L ++K+ L    K  +LK+   ++Q T  + Q   E  
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQ-TVQQEQLLQETQ 2516

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNL---KLGTLNGSQEEMWQKTETVKQENAAVQ 1575
              +   L +++S+L+ E     E+  +  L   ++      +EE  ++ + ++QE   + 
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576

Query: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
              +E  +++  E +   ++   E  +L Q+  Q +E L E NQRL E L           
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL---------QL 2627

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLV----SSLEAELSEV-----------KIQTHIVQQ 1680
            LEE+ +      EE+   +V ++  +     +L+   +E            K+    +Q+
Sbjct: 2628 LEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687

Query: 1681 ENHLLKDELEKMKQLH-------RCPDLSDFQQKISSVLSYNEKLLKEK 1722
               L  +EL+++ Q H       R  D+  + Q  SS+     K   EK
Sbjct: 2688 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEK 2736



 Score =  172 bits (437), Expect = 2e-42
 Identities = 361/1723 (20%), Positives = 685/1723 (39%), Gaps = 278/1723 (16%)

Query: 537  ERLTQMRNEYERQCRVLQDQVD-ELQSELEEYRAQGRVLRLPLKNSPSEE---------- 585
            + L Q   E  R  R + +  D  LQ E  E R   R LRLPL   P+ E          
Sbjct: 997  QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQK 1055

Query: 586  ----VEANSGGI-----EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-- 634
                VE    G+     E E  L   E +P   ++ +EL +   K +  R +  + LE  
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1115

Query: 635  ------------LEDKVRHYEKQLDET---------VVSCKKAQENMKQRHENETHTLEK 673
                         E+ +R +E+QL E          + + K + + ++ + E +  T + 
Sbjct: 1116 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175

Query: 674  QISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEME- 732
                L++E+   Q     L++ H E     E  ++++   LE  +  L +    Q E+E 
Sbjct: 1176 ----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231

Query: 733  LKARLTQAQASFEREREGLQSSAWTEEKVRGL----TQEL-EQFHQEQ-LTSLVEKHTLE 786
            L  +L   + S +     LQ +   +E+++ +    +Q + EQ  QEQ L   +E+H  +
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291

Query: 787  KEELRK------ELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTERCE--S 837
             EE ++        ++ ++ +L   + ++E   +  +  ++++  +S  Q+  +     S
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
             L +L  +Y + + +   +  EE+   E ++ E  +  AE +  L++  +  +  +    
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411

Query: 898  Q-EREMLEKTYKEHLNSMVVERQQLLQDL--------EDLRNVSETQQSLLSDQILELKS 948
            Q ERE   K  ++ +   VV R++   D         E+L+ + ++ ++ +  +  + ++
Sbjct: 1412 QAEREA--KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469

Query: 949  SHKRELREREE---VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCE 1005
            + +  LR  EE   V  Q  A+E+        L+    +  +    K  A E   +   +
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
              D  + +   E+  L S++K   +A       Q   Q + E  ++ + A   L+Q E  
Sbjct: 1530 VQDESQRKRQAEVE-LASRVKAEAEAAREK---QRALQALEELRLQAEEAERRLRQAE-- 1583

Query: 1066 LEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
            +E    V ++L+ A   A  E   K A+   +  Q  + L+   V  + L E A      
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 1125 TAE------QTEPFLQQNRTK---------QVEGVTRRHVLSDLEDD--------EVRDL 1161
             AE      + E  L++ + K         Q E V ++  L+  E +        E R  
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703

Query: 1162 GSTGTSSVQRQEV---KIEESEASVEGFSELENSEET-----RTESWELKNQISQLQEQL 1213
            G     +V+++E+   ++E+     EG ++   + E      R E+ + + Q   L+E+L
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763

Query: 1214 MMLCADCDRASEKKQDLLFDVSVLKKKLKML-------------------ERIPEASPKY 1254
              L  +   A++K+Q+L  +++ ++ ++++L                   +R+   + ++
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
            + L E+ +R     +E  R  +   ++A     E       L ++L  + E T      E
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKLAAIGEATRLKTEAE 1880

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLN 1373
             +  E + ENE L  L      +  +L+E   Q + D    E  L  L    D  + +  
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQK 1937

Query: 1374 QTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQL---LEKVKAHEIAWLHGTIQTHQERP 1429
              +E+ + + R V   I   K    +   G  +L   L +++++    L    Q   E  
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997

Query: 1430 RVQNQVILEENT-----------TLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERV 1478
            R Q Q+  EE             +L   ++   Q +A + E+E  K K++E  R+L+ER 
Sbjct: 1998 R-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERA 2055

Query: 1479 T------ILVKQKDVLSHGEKEEELKAMM-----HDLQITCSEMQQKVELLRYESEKLQQ 1527
                   + + Q+      + EE+  A        +LQ T  + Q  ++ LR E+E  ++
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
                          E + S  ++       E + Q  E   Q  A  Q   E L+K+  +
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVE----EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL--EEREQEKFN 1645
               +  Q +       Q      EK ++  ++      Q E+E     L  EE + +K  
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231

Query: 1646 LKEELERCKVQSSTLV---SSLEAELSEVKIQTHI-------VQQENH------------ 1683
            L EEL+R K +++      S +E EL  V++Q          ++ EN             
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291

Query: 1684 LLKDELEKMKQL-HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEEL--------NSCVD 1734
             L++E EKMKQ+      LS   Q+ + +    E+ L ++ AL+E++             
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351

Query: 1735 KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMS----R 1790
              A++ LL+ +    +++ +  +     +  QL    +  Q   +  +   L+MS    R
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
            +K  +    + +   +++     KQ +  G K    E+AT       Q   +   + DH 
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH- 2470

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
                      + ERL+  +    AEL   +EK++Q E+ LL    +       M   +QE
Sbjct: 2471 ----------DAERLREAI----AELEREKEKLQQ-EAKLLQLKSEE------MQTVQQE 2509

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
            +L         Q+ Q+     +S+ +SL Q    I  E E  K +Q+  DE + + Q LR
Sbjct: 2510 QL--------LQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDE-VAKAQQLR 2558

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
                                           + QRQ  Q E+  Q L   +E    E   
Sbjct: 2559 E------------------------------EQQRQQQQMEQERQRLVASME----EARR 2584

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             Q   E+ V   +E + ++EQ+ +  + LL E+  +L+EQ+ L
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2627



 Score =  123 bits (308), Expect = 2e-27
 Identities = 207/904 (22%), Positives = 373/904 (41%), Gaps = 161/904 (17%)

Query: 326  ENSQEILKALDFSLDGNINLTELTLA----LENELLVTKNSIHQAAL--ASFKAEIRHLL 379
            E   ++ KA D  L+    L E TL     +E E+L  K S  +AA   A  + E+  + 
Sbjct: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979

Query: 380  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 439
               +  +R KE+  ++L+ A + +  +A+E +      E R + +L   +E  ++R AAL
Sbjct: 1980 SNAEDTLRSKEQ--AELEAARQRQ--LAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035

Query: 440  KN---------ELRKERE----------QILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
            +          E R+ RE          Q+ Q+A ++RL+ E++      ++      L 
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK--EQELQ 2093

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
             +L++   + ++L   AE          + +   E   A+    ++        + ERL 
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--------EAERLK 2145

Query: 541  QMRNEYERQCRVLQDQVDELQSELEE---YRAQGRVLRLPLKNSPSEEVEANSGGIEPEH 597
            Q   E  +     Q   ++L+ E E+    RAQ     L  K +   E+E +        
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK------ 2199

Query: 598  GLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KA 656
                           AE  + Q K Q  +++  LRL+LE+   H +  LDE +   K +A
Sbjct: 2200 --------------FAEQTLRQ-KAQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEA 2243

Query: 657  QENMKQRHENETHTLE-----KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
             E  +QR + E          +++S LK  I E + +A +L++  +      EE +K  Q
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNTQRFLQEEAEKMKQ 2302

Query: 712  VKLEEEKTHL--QEKLRLQH--EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
            V  E  +  +  QE  RL+   E +L  +   A+   + + + +Q +   + +   L Q+
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQ 2361

Query: 768  LEQFHQEQLTSLVEKHTLEKEELRKELLEK---HQRELQEGREK---METECNR------ 815
             ++  QEQ   L E    +KE++ ++L E+    QR L+  R++   M  E  R      
Sbjct: 2362 QKELAQEQARRLQE----DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417

Query: 816  RTSQIEAQFQSDCQKVTERCESALQSLEGR--YRQELKDLQEQQREEKSQWEFEKDELTQ 873
              S+ +A+ + D Q+  ++ E   + L       QE   L +    ++ Q + + + L +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
              AE        L+REK     L QE ++L+   +E      V+++QLLQ+ + L     
Sbjct: 2478 AIAE--------LEREKEK---LQQEAKLLQLKSEE---MQTVQQEQLLQETQAL----- 2518

Query: 934  TQQSLLS--DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMS 991
             QQS LS  D +L+ +   ++E  + E++     A  Q   +  +R + + +QERQ ++ 
Sbjct: 2519 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2576

Query: 992  KLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
                      A+ E A R + E    + R Q ++++++Q                     
Sbjct: 2577 ----------ASMEEARRRQHEAEEGVRRKQEELQQLEQQRR------------------ 2608

Query: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
                    QQ E L EEN  +   LQ   EQ  +  +  + E++  Q    K  P     
Sbjct: 2609 --------QQEELLAEENQRLREQLQLLEEQH-RAALAHSEEVTASQVAATKTLPN--GR 2657

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
              LD PA E     AE    F    R    + +    +LS  E   +    +T     +R
Sbjct: 2658 DALDGPAAE-----AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2712

Query: 1172 QEVK 1175
            ++V+
Sbjct: 2713 EDVR 2716



 Score =  111 bits (278), Expect = 6e-24
 Identities = 293/1437 (20%), Positives = 565/1437 (39%), Gaps = 206/1437 (14%)

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            L Q LEQ  QE+  S  ++   E +++R +L     R +   R  ++ E  R  +Q  A+
Sbjct: 995  LLQSLEQGAQEE--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1052

Query: 824  FQSDCQKVTERCESALQ-SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELL 882
             Q    +V    +   + S E      L +        +S+ E    +L Q     + L 
Sbjct: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VRSLS 1108

Query: 883  KETLKREKTTSLVL--TQEREMLEKTYKEHLN------SMVVERQQLLQDLEDLRNVSET 934
               L++ KT SLV+  TQ  E + + ++E L       + + E +     L+ LR  +E 
Sbjct: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168

Query: 935  QQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKL 993
            QQ            + + ELR  +EV       E+L  +  ER +E+E  +ER   +   
Sbjct: 1169 QQPTFD--------ALRDELRGAQEV------GERLQQRHGERDVEVERWRERVAQL--- 1211

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPL-SMLQSGC----QVIGEE 1048
              +E       +T  R+R     E+ +L  +++  +++  PL + LQ       Q+    
Sbjct: 1212 --LERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 1049 EVEGDGALSLLQQGEQLLEE---NGDVLLSLQRAHEQ---AVKE-NVKMATEISRLQQRL 1101
              +       L+Q + LLEE   +G+ +   QR  +Q   A+K+  +++ T  ++L+   
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324

Query: 1102 QKLEPGLVMS-------------------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               +   V S                   + L     +F   T  + E   ++ R  + +
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQ 1381

Query: 1143 GVTRRHVLSDLED--DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW 1200
                R  L+++E   ++ R L      +  + E + +E +  ++   E+   EE   ++ 
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQ 1439

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED 1260
            + K  I +  +QL    ++ +  ++ +Q    + S L        RI E     +L  E 
Sbjct: 1440 QQKRSIQEELQQLRQ-SSEAEIQAKARQAEAAERSRL--------RIEEEIRVVRLQLEA 1490

Query: 1261 VSRENDCLQEELRMMETRYDEALENNKELTAEVFRL----QDELKKMEEVTETFLSLEKS 1316
              R+    + EL+ +  R +EA    ++   E  RL    QDE ++  +      S  K+
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1550

Query: 1317 YDEVKIENEE----LNVLVLRLQGKIEKLQESVVQRC----------------------- 1349
              E   E +     L  L L+ +    +L+++ V+R                        
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610

Query: 1350 DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ--YLEGNTQLL 1407
                  A LE    E    + QL +  E    +        EE ++E +   L+ N  L 
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1670

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             +++A E+A      Q   E+ + +     E      G  ++    Q  +AE ELEK + 
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQELEKQR- 1725

Query: 1468 QELTRKLKERVTI---LVKQKDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESE 1523
            Q      ++R+     L++ +     GE++ +L +  +  LQ   +   QK + L  E  
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            K++ E  +L        EE   ++ K      ++   +++   + +E A ++ + E  K+
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---LAEEAARLRALAEEAKR 1842

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQE 1642
            Q    ++  +    +  E  +  ++    + E  +  TE  +  KEKE  N  L    ++
Sbjct: 1843 Q---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1702
            +   +  LE    Q    +    A+L   K     ++++  L++D L + +Q+       
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLR--KASDSELERQKGLVEDTLRQRRQV------- 1950

Query: 1703 DFQQKISSVLSYNEKLLKEKEALSEEL----NSCVDKLAKSSLLEHRIATMKQ----EQK 1754
              +++I ++ +  EK    K  L  EL    ++  D L      E   A  +Q    E++
Sbjct: 1951 --EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2008

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                    ++  L A +E  +  +  ++ V     R+K+ +   ++ +E  +QE     +
Sbjct: 2009 RRREAEERVQKSLAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQ 2064

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSW------DKLDHLMNE-----------EQQL 1857
              Q A  K    E   H   +  +++ L          LD L  E           E+  
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124

Query: 1858 LWQENERLQTMVQNTKAE-LTHSREKVRQLESNLLPKHQKHLNPS----GTMNPTEQEKL 1912
            +  E E  Q+  Q  +AE L  S E+  Q  +      +K    +          EQ  L
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184

Query: 1913 SLKRECD-QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRS 1971
              K+  D + +K +  A + + Q   +EQEL T+ L+ E    ++  LDE   E+Q L++
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKA 2241

Query: 1972 TATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ-------RQLLQAERIN--QHLQEELE 2022
             AT +    +   Q+ ++     V  E+  +L+       R L+  ++ N  + LQEE E
Sbjct: 2242 EATEAARQRS---QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2298

Query: 2023 ------NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
                     +  +       +L  + EE   ++ Q+  L +++L+EK+  ++E   L
Sbjct: 2299 KMKQVAEEAARLSVAAQEAARLRQLAEE---DLAQQRALAEKMLKEKMQAVQEATRL 2352


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  170 bits (431), Expect = 1e-41
 Identities = 342/1676 (20%), Positives = 710/1676 (42%), Gaps = 232/1676 (13%)

Query: 400  EKLKSLMASEVDDHHAAIERRNEYNLRKLDE----------EYKERIAALKNELRKEREQ 449
            ++LK   + E+DDH   +      + +KL E          +Y+ERI  L+N L++    
Sbjct: 219  KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278

Query: 450  ILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNK 509
            +++    +  E+++ I+  + E+         S K+  +LE+++ +  +KL+  EN  + 
Sbjct: 279  VIETDLSKIYEMQKTIQVLQIEK-------VESTKKMEQLEDKIKDINKKLSSAENDRDI 331

Query: 510  LQRNLENVLAEK-------------FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ 556
            L+R  E +  EK                L PS+ +   Q + +T+      +   V  ++
Sbjct: 332  LRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK---QSDTMTEKERILAQSASV--EE 386

Query: 557  VDELQSELEEYRAQGRVLRLPLKNSPSEEVEAN------SGGIEPEHGLGSEECNPLNMS 610
            V  LQ  L +  A+  ++RL   N  +   E N         +E E  L S+E   L MS
Sbjct: 387  VFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMS 444

Query: 611  -IEAELVIEQMKEQHHRDICC------LRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 663
             ++     E +K    RDI        LRL LE K +   + + E      + +E  +Q 
Sbjct: 445  LLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQN 504

Query: 664  HENETH--TLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHL 721
             E   H   ++ Q+S  +NE     G + + K           +EKK++  +LE++K  +
Sbjct: 505  QEATKHMILIKDQLSKQQNE-----GDSIISKLKQD-----LNDEKKRVH-QLEDDKMDI 553

Query: 722  QEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE 781
             ++L +Q E  +++ +        +++         E+KV  L  +L +  +  ++  ++
Sbjct: 554  TKELDVQKEKLIQSEVALNDLHLTKQK--------LEDKVENLVDQLNKSQESNVS--IQ 603

Query: 782  KHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQS 841
            K  LE     KE + +++ EL   R ++    N+ ++   + F+    K  ER E+ +++
Sbjct: 604  KENLE----LKEHIRQNEEELSRIRNELMQSLNQDSN---SNFKDTLLK--ER-EAEVRN 653

Query: 842  LEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL------- 894
            L+ +   EL+ L E  ++     + E ++L   C + +  L+E L      SL       
Sbjct: 654  LK-QNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVE 712

Query: 895  VLTQEREMLEKTY---KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHK 951
             L  E+  +E      K+ L     + ++ +++L + RN++ +   L  + +++L     
Sbjct: 713  TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 772

Query: 952  REL--------------REREEVLCQAGASEQLASQRLERLEMEHD---------QERQE 988
             E+              +E ++VL  +   ++  +Q + + E+  +         QE  +
Sbjct: 773  MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832

Query: 989  MMSKLLAMENIHKATCETADRERAEMSTEISRLQ---SKIKEMQQATSPLS---MLQSGC 1042
              S+ L    I + T E  DR    M  E + LQ    +++E Q  T+P++    L S  
Sbjct: 833  KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT 892

Query: 1043 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQ 1102
            ++  E        +S L   ++ LEE        +  H Q + E+        + Q ++Q
Sbjct: 893  ELASE--------VSQLNTIKEHLEE--------EIKHHQKIIED--------QNQSKMQ 928

Query: 1103 KLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLG 1162
             L+        +DE   +     A  T+ FL+++   +    T   + + L  +E +D+ 
Sbjct: 929  LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH-EERQDIQ 987

Query: 1163 STGTSSVQRQEVKIEESEASVEGFSELENSEETRTESW-----ELKNQISQLQEQLMMLC 1217
            +  +   Q  +V+      ++E  SE  +  +  TE       E + +I  L E+ + L 
Sbjct: 988  TDNSDIFQETKVQ----SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLT 1043

Query: 1218 ADCDRASEKKQDLLFDVSVLKKKLK---MLERIPEASPKYKLLYEDVSRENDCLQEELRM 1274
               D+ S+ +   L  + + +K L+   +  RI   S    ++Y         LQ++L+ 
Sbjct: 1044 KQIDQLSKDEVGKLTQI-IQQKDLEIQALHARISSTSHTQDVVY---------LQQQLQA 1093

Query: 1275 METRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
                 ++      E T E   L+ E  KM ++     + E +  +++ EN++L+    R 
Sbjct: 1094 YAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV---AAKEAALIKLQDENKKLST---RF 1147

Query: 1335 QGKIEKLQESVVQRCDCCLWEASLE----NLEIEPDGNILQLNQTLEECVPRVRSVHHVI 1390
            +   + +    +Q     + E  +E    + + +    +LQ + T  E    V S  +  
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE-AGGVNS--NQF 1204

Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWL----HGTIQTHQERPRVQNQVILE-ENTTLL- 1444
            EE  QE   L+   + +E+ K   +  +    H + Q  +E  ++Q QV+++ +N + L 
Sbjct: 1205 EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQ 1264

Query: 1445 ----GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1500
                G    + Q++  +     E  ++Q    +L     +L+ + D++S    +    ++
Sbjct: 1265 VDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS---PQLSSASL 1321

Query: 1501 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNE-------ITTLNEED-SISNLKLGT 1552
            +      C     K E+L   SE LQQE   LR         I TL E +  +S+    T
Sbjct: 1322 LTPQSAECLR-ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT 1380

Query: 1553 LNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1612
                ++E  Q    +KQ       + + LK++   +K K+ QL   N   + K ++N E 
Sbjct: 1381 SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNEN-EL 1439

Query: 1613 LQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVK 1672
            L++    L E +   E + G    E  +  +    +E E   +Q + +  S+   L E +
Sbjct: 1440 LRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM--MLREKE 1497

Query: 1673 IQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSC 1732
             + H + +E  L  ++L K K+  +  +L+   Q +++V S  EK +  ++   + + + 
Sbjct: 1498 FECHSM-KEKALAFEQLLKEKEQGKTGELN---QLLNAVKSMQEKTVVFQQERDQVMLAL 1553

Query: 1733 VDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK 1792
              K  +++ L++ +  ++ ++     +   L++ L+ S       ED+     L     +
Sbjct: 1554 KQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLES-------EDSYTREALAAEDRE 1606

Query: 1793 SDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1852
            + LR   ++   L+++++S    ++NA  ++ + ++ +    L+   K+     L   ++
Sbjct: 1607 AKLR---KKVTVLEEKLVSSSNAMENASHQA-SVQVESLQEQLNVVSKQRDETALQLSVS 1662

Query: 1853 EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP--TEQE 1910
            +EQ       ++    + N +  L H +++ + + S  L K QK L      N    E +
Sbjct: 1663 QEQV------KQYALSLANLQMVLEHFQQEEKAMYSAELEK-QKQLIAEWKKNAENLEGK 1715

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM 1966
             +SL+   D+       A+R   Q++  E+++E +  +NE  ++    + ++LM +
Sbjct: 1716 VISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSL 1771



 Score =  158 bits (399), Expect = 6e-38
 Identities = 361/1779 (20%), Positives = 710/1779 (39%), Gaps = 295/1779 (16%)

Query: 436  IAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLE 495
            +A+L  ++    + +L +  +   E+E E+  ++T+E  I    A+   EN RL+    +
Sbjct: 23   LASLTGQISNFTKDMLMEGTE---EVEAELPDSRTKE--IEAIHAILRSENERLKKLCTD 77

Query: 496  NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQD 555
              EK    E    +   +  N L +K  ++    A                 RQ   LQD
Sbjct: 78   LEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKA-----------------RQI-ALQD 119

Query: 556  QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAEL 615
            Q+ +LQS  +   +   V   P   + S    + + GI        ++       I ++ 
Sbjct: 120  QLLKLQSAAQSVPSGAGV---PATTASS----SFAYGISHHPSAFHDDDMDFGDIISSQQ 172

Query: 616  VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQI 675
             I ++  +  R        LE +V H+       +    KAQ       ++E   L+  I
Sbjct: 173  EINRLSNEVSR--------LESEVGHWRH-----IAQTSKAQ-GTDNSDQSEICKLQNII 218

Query: 676  SDLKN----EIAELQGQAAVLKEAHH----EATCRHEEEKKQLQVKLEEEKTHLQEKLRL 727
             +LK     EI + Q + +VL+ AH     E + RH EE    + ++EE +  LQ+    
Sbjct: 219  KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278

Query: 728  QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 787
              E +L       +     + E ++S+    +K+  L  +++  +++  ++  ++  L +
Sbjct: 279  VIETDLSKIYEMQKTIQVLQIEKVEST----KKMEQLEDKIKDINKKLSSAENDRDILRR 334

Query: 788  EELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYR 847
            E+   E L   +R++ E  E ++ EC++   Q  A  QSD     ER  +   S+E  +R
Sbjct: 335  EQ---EQLNVEKRQIMEECENLKLECSKL--QPSAVKQSDTMTEKERILAQSASVEEVFR 389

Query: 848  --QELKDLQ--------------------------EQQREEKSQWEFEKDELTQECAEAQ 879
              Q L D +                          E   +EKS    EK+EL     +  
Sbjct: 390  LQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLN 449

Query: 880  ---ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQ 936
               E++K T  R+ +    L   R  LE   +E LN  + E++ L+ ++E+L    + Q 
Sbjct: 450  NEYEVIKSTATRDISLDSELHDLRLNLEAKEQE-LNQSISEKETLIAEIEEL----DRQN 504

Query: 937  SLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE-------MEHDQERQEM 989
               +  ++ +K    ++  E + ++ +         +R+ +LE        E D +++++
Sbjct: 505  QEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKL 564

Query: 990  MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM--LQSGCQVIGE 1047
            +   +A+ ++H          + ++  ++  L  ++ + Q++   +    L+    +   
Sbjct: 565  IQSEVALNDLHLT--------KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616

Query: 1048 EEVEGDGALSLLQQGEQLLEEN-GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP 1106
            EE        L+Q   Q    N  D LL  + A  + +K+N+   +E+ +L + L+K+  
Sbjct: 617  EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNL---SELEQLNENLKKVAF 673

Query: 1107 GLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGT 1166
             + M +   E       +   Q E  L  N    +E  T    L         + G    
Sbjct: 674  DVKMEN---EKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLK-------MEKGEIEA 723

Query: 1167 SSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQ------------ISQLQEQLM 1214
                 ++  +EE+    +   EL N+    T + +L+++            I++L++ + 
Sbjct: 724  ELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIE 783

Query: 1215 MLCADCDRASEKKQDLLFD----VSVLKKKLKMLERIPEASPKYKL---LYEDVSRENDC 1267
             +  D     +     L +      ++ KK   +E++ E S K +     Y    R+N+ 
Sbjct: 784  QMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI 843

Query: 1268 LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL 1327
            L++ +   +       E N  L  E+ RL++E  +   V +       S  E+  E  +L
Sbjct: 844  LRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADP--KTLDSVTELASEVSQL 901

Query: 1328 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
            N +   L+ +I+  Q+ +  +                 + + +QL Q+L+E    +    
Sbjct: 902  NTIKEHLEEEIKHHQKIIEDQ-----------------NQSKMQLLQSLQEQKKEMDEFR 944

Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI-----QTHQERPRVQ---NQVILEE 1439
            +      Q  Q    +TQL  + K  EI  L  TI     Q H+ER  +Q   + +  E 
Sbjct: 945  Y------QHEQMNATHTQLFLE-KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQET 997

Query: 1440 NTTLLGFQDKHFQHQATIAELE--LEKTKLQELTRKL-KERVTILVKQKDVLSHGE---- 1492
                L  ++   +H  + AE E  ++  K +EL  KL  E+   L KQ D LS  E    
Sbjct: 998  KVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKL 1057

Query: 1493 ----KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1548
                ++++L+      +I+ +   Q V  L+ + +    E    R ++  +  E +  N 
Sbjct: 1058 TQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME----REKVFAVLNEKTRENS 1113

Query: 1549 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTE-LSQKNS 1607
             L T      E  +  + V  + AA+ K+ +  KK  +  +   Q +  E  + LS+   
Sbjct: 1114 HLKT------EYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167

Query: 1608 QNQEKLQELNQRLTEMLCQKE-KEPGNSA-------LEEREQEKFNLKEE---LERCKVQ 1656
            +   ++  L+Q+   +L   +    GN A        EE  QE+  LK++   +E  K Q
Sbjct: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQ 1227

Query: 1657 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-------QLHRCPD--LSDFQQK 1707
              T V +++ E ++++ + H +Q +  +  D   K++       Q +   +  L +F Q+
Sbjct: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287

Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS--WEHQSASLKS 1765
            ++ V     +L   K+ L  +L+    +L+ +SLL  + A   +  KS      S  L+ 
Sbjct: 1288 LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347

Query: 1766 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA 1825
            +L   ++ +Q  + T++ +     R+   +  T + +    ++  S  KQL+        
Sbjct: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK-------- 1399

Query: 1826 PEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQ--ENERLQTMVQNTK---------- 1873
             E       L  ++  L   K D L++  +    +  ENE L+  V N K          
Sbjct: 1400 -EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDI 1458

Query: 1874 AELTHSREKV----RQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ-----KE 1924
             +L    EK+    R  E+      + ++  S  +   E E  S+K +   F+     KE
Sbjct: 1459 GKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKE 1518

Query: 1925 QSPA---NRKVSQMNSLEQELETIHLENE----GLKKKQVKLDEQLMEMQHLRSTATPSP 1977
            Q      N+ ++ + S++++      E +     LK+KQ++      E+Q LR       
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD------ 1572

Query: 1978 SPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQ 2037
                                ++F   Q    + ER+  HL E  ++ T E    +  + +
Sbjct: 1573 --------------------KEFRSNQ----ELERLRNHLLESEDSYTREALAAEDREAK 1608

Query: 2038 L---VTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
            L   VTV+EE+++     ++        +V  L+EQ+++
Sbjct: 1609 LRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNV 1647



 Score =  151 bits (381), Expect = 7e-36
 Identities = 306/1504 (20%), Positives = 634/1504 (42%), Gaps = 208/1504 (13%)

Query: 365  QAALASFKAEIRHL--LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD-HHAAIERRN 421
            Q AL+  + EI  L  L + + +  +  KL+  ++  EK KSL++ E ++   + ++  N
Sbjct: 391  QQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450

Query: 422  EYNLRKLDEEYKERIAALKNELR---KEREQILQQAGKQRLELEQEIEKAKTEENYIRDR 478
            EY + K        + +  ++LR   + +EQ L Q+  ++  L  EIE+   +       
Sbjct: 451  EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 510

Query: 479  LALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEER 538
            + L   + S+ +NE      KL +  N   K    LE+   +   +LD       +Q+E+
Sbjct: 511  MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELD-------VQKEK 563

Query: 539  LTQMR---NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEP 595
            L Q     N+     + L+D+V+ L  +L +                             
Sbjct: 564  LIQSEVALNDLHLTKQKLEDKVENLVDQLNK----------------------------- 594

Query: 596  EHGLGSEECNPLNMSIEAE-LVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK 654
                 S+E N   +SI+ E L +++   Q+  ++  +R EL   +            S  
Sbjct: 595  -----SQESN---VSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD---------SNS 637

Query: 655  KAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV-- 712
              ++ + +  E E   L++ +S+L+     L+  A  +K  + +     E+ + QL+   
Sbjct: 638  NFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697

Query: 713  ----KLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQEL 768
                +L  EK  + E L+++ + E++A L  A+     E    + +       R L    
Sbjct: 698  AGNNQLSLEKNTIVETLKME-KGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSA 756

Query: 769  EQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMET--ECNRRTSQIEAQFQS 826
             Q   E L  L +K  +E  EL+K + E+   + +E ++ + +  E  ++ +Q+  + + 
Sbjct: 757  LQLEHEHLIKLNQKKDMEIAELKKNI-EQMDTDHKETKDVLSSSLEEQKQLTQLINKKEI 815

Query: 827  DCQKVTERCESALQSLEGRYRQELK--DLQEQQREEKSQWEFEKDELTQECAEAQELLKE 884
              +K+ ER  S LQ    +Y Q L+  ++  Q  EEK +      E      E  E L+E
Sbjct: 816  FIEKLKER-SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLRE 874

Query: 885  TLKRE------KTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQD-----LEDLRNVS 932
               R       KT   V     E+ +  T KEHL   +   Q++++D     ++ L+++ 
Sbjct: 875  EQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ 934

Query: 933  ETQQSL--LSDQILELKSSHKRELRER-EEVLCQAGASEQLASQ-RLERLEMEHDQER-- 986
            E ++ +     Q  ++ ++H +   E+ EE+       EQ+ +Q   ER +++ D     
Sbjct: 935  EQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIF 994

Query: 987  QEMMSKLLAMEN------IHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
            QE   + L +EN      + KA  E   +   E   EI  L  K   + +    LS  + 
Sbjct: 995  QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEV 1054

Query: 1041 G--CQVIGEEEVE-------------GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVK 1085
            G   Q+I ++++E                 + L QQ +    E   V   L     +  +
Sbjct: 1055 GKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLN----EKTR 1110

Query: 1086 ENVKMATEISRLQQRLQKLEPGLV--------MSSCLDEPATEFFGNTAEQTEPFLQQNR 1137
            EN  + TE  ++   +   E  L+        +S+  +    + F  T +     +++ +
Sbjct: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIRE-K 1169

Query: 1138 TKQVEGVTRR--HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEET 1195
              +++ ++++   +L+ L+     +    G +S Q +E+  E  +   +     E  ++ 
Sbjct: 1170 DIEIDALSQKCQTLLAVLQTSSTGNEAG-GVNSNQFEELLQERDKLKQQVKKMEEWKQQV 1228

Query: 1196 RTESWELKNQISQLQEQLMMLCA----DCDRASEKKQDLLFDVSVLKKKLKMLERIPEAS 1251
             T    ++++ +QLQE+L  L A    D D  S+ + D    +   ++    L+   +  
Sbjct: 1229 MTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQEL 1288

Query: 1252 PKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL 1311
             + +     +    D L  +L ++  +   A     + +AE  R      K E ++E+  
Sbjct: 1289 AQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQ-SAECLRAS----KSEVLSESSE 1343

Query: 1312 SLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP-DGNIL 1370
             L++  +E++   +E +  +  LQ    +L +S+    +       LE  E E  D  I 
Sbjct: 1344 LLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSE-------LERKEHEQTDSEIK 1396

Query: 1371 QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPR 1430
            QL +  ++ + ++     ++ + K + Q L  N     KV  +E+  L   +   +ER  
Sbjct: 1397 QLKEK-QDVLQKLLKEKDLLIKAKSD-QLLSSNENFTNKVNENEL--LRQAVTNLKERIL 1452

Query: 1431 V----------QNQVILE----ENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKE 1476
            +          +N+ I+E    + T     Q+ + +    + E E E   ++E     ++
Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512

Query: 1477 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1536
                L+K+K+    GE  + L A+    + T    Q++ +++    +K Q EN+ L+NE+
Sbjct: 1513 ----LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQK-QMENTALQNEV 1567

Query: 1537 TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLD 1596
              L +++  SN +L  L   +  + +  ++  +E  A +     L+K+++ L+ K     
Sbjct: 1568 QRLRDKEFRSNQELERL---RNHLLESEDSYTREALAAEDREAKLRKKVTVLEEK----- 1619

Query: 1597 LENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQ 1656
            L ++  + +N+ +Q  +Q   + L E L        N   ++R++    L    E+ K Q
Sbjct: 1620 LVSSSNAMENASHQASVQV--ESLQEQL--------NVVSKQRDETALQLSVSQEQVK-Q 1668

Query: 1657 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1716
             +  +++L+  L       H  Q+E  +   ELEK KQL     ++++++   ++     
Sbjct: 1669 YALSLANLQMVLE------HFQQEEKAMYSAELEKQKQL-----IAEWKKNAENL---EG 1714

Query: 1717 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1776
            K++  +E L +E N+ +D    +S L  ++   +++ +  + Q+   +  L   Q+K+ +
Sbjct: 1715 KVISLQECL-DEANAALD---SASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMS 1770

Query: 1777 LEDT 1780
            L ++
Sbjct: 1771 LANS 1774



 Score =  141 bits (355), Expect = 8e-33
 Identities = 301/1442 (20%), Positives = 581/1442 (40%), Gaps = 251/1442 (17%)

Query: 325  IENSQEILKAL---DFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 381
            + N  E++K+    D SLD  ++   L L  + + L    S  +  +A  +   R   E 
Sbjct: 448  LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507

Query: 382  VDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 441
               ++  K++L    ++ + + S +  +++D    + +  +  +    E   ++   +++
Sbjct: 508  TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQS 567

Query: 442  ELRKEREQILQQAGKQRLE-LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 500
            E+      + +Q  + ++E L  ++ K++ E N    +  L LKE+ R   E        
Sbjct: 568  EVALNDLHLTKQKLEDKVENLVDQLNKSQ-ESNVSIQKENLELKEHIRQNEE-------- 618

Query: 501  AEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFLQEERLTQMRNEYERQCRVLQD--- 555
             E   + N+L ++L       F D  L    AE    ++ L+++    E   +V  D   
Sbjct: 619  -ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM 677

Query: 556  -------QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLN 608
                     ++++ +LEE  A    L L  KN+  E ++   G IE E  L   +   L 
Sbjct: 678  ENEKLVLACEDVRHQLEECLAGNNQLSLE-KNTIVETLKMEKGEIEAE--LCWAKKRLLE 734

Query: 609  MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 668
             + + E  IE++    + +   L+LE E  ++  +K+ D  +   KK  E M   H+   
Sbjct: 735  EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK-DMEIAELKKNIEQMDTDHKETK 793

Query: 669  HTL------EKQISDLKNE----IAELQGQAAVLKE---AHHEATCRHE------EEKKQ 709
              L      +KQ++ L N+    I +L+ +++ L+E    + +A  ++E      EEK +
Sbjct: 794  DVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853

Query: 710  LQVKLEEEKTHLQEKL-RLQHEM----------------ELKARLTQAQASFEREREGL- 751
                ++EE  HLQE+L RL+ E                 EL + ++Q     E   E + 
Sbjct: 854  SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIK 913

Query: 752  ----------QSSAWTEEKVRGLTQELEQF--HQEQLTSLVEKHTLEKEELRKEL---LE 796
                      QS     + ++   +E+++F    EQ+ +   +  LEK+E  K L   +E
Sbjct: 914  HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973

Query: 797  KHQRELQEGREKMETECNRRTSQIEAQF--------QSDCQKV-TERCESALQSLEGRYR 847
            + + +L E R+ ++T+ +    + + Q         + D  K  TER    ++  E    
Sbjct: 974  QIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE---- 1029

Query: 848  QELKDLQEQQREEKSQW-EFEKDEL--------------------------TQECAEAQE 880
             E+K L E+      Q  +  KDE+                          TQ+    Q+
Sbjct: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089

Query: 881  LLKE-TLKREKTTSLV--LTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS 937
             L+   ++REK  +++   T+E   L+  Y + ++ +  +   L++  ++ + +S   +S
Sbjct: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149

Query: 938  LLSDQILELKSSHKRELREREEVL------CQ-----------AGASEQLASQRLERLEM 980
               D   E   +  R +RE++  +      CQ              +  + S + E L  
Sbjct: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209

Query: 981  EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
            E D+ +Q+ + K+   +     T +    E A++  E+ +LQ+++       S L     
Sbjct: 1210 ERDKLKQQ-VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKL----- 1263

Query: 1041 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1100
                    +V+  G +   +Q E  L+  G  L  +Q +  Q       +      L  +
Sbjct: 1264 --------QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ-------LCNTKDLLLGK 1308

Query: 1101 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1160
            L  + P L  +S L   + E     A ++E   + +   Q E    R  L + +D  +R 
Sbjct: 1309 LDIISPQLSSASLLTPQSAECL--RASKSEVLSESSELLQQELEELRKSLQE-KDATIRT 1365

Query: 1161 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1220
            L        Q    ++ +S A+    SELE  E  +T+S E+K Q+ + Q+ L  L  + 
Sbjct: 1366 L--------QENNHRLSDSIAAT---SELERKEHEQTDS-EIK-QLKEKQDVLQKLLKEK 1412

Query: 1221 DRASEKKQD-LLFDVSVLKKKLKMLERIPEASPKYK----LLYEDVSR---ENDCLQEEL 1272
            D   + K D LL        K+   E + +A    K    +L  D+ +   EN+ + E  
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472

Query: 1273 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1332
            R  ET Y    E N + +  +   + E   M+E    F  L K  ++ K    ELN    
Sbjct: 1473 RGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK--TGELN---- 1526

Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEE 1392
            +L   ++ +QE  V               + E D  +L L Q   E       V  + ++
Sbjct: 1527 QLLNAVKSMQEKTVV-------------FQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573

Query: 1393 CKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV-ILEENTTLLGFQDKHF 1451
              + NQ LE   +L   +   E ++    +       +++ +V +LEE         ++ 
Sbjct: 1574 EFRSNQELE---RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENA 1630

Query: 1452 QHQATIAELELEKTKLQELTRKLKERVTILVKQKD--VLSHGEKEEELK---AMMHDLQI 1506
             HQA++                L+E++ ++ KQ+D   L     +E++K     + +LQ+
Sbjct: 1631 SHQASVQ------------VESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQM 1678

Query: 1507 TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET 1566
                 QQ+ E   Y +E  +Q+  I   +    N E  + +L+               E 
Sbjct: 1679 VLEHFQQE-EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ---------------EC 1722

Query: 1567 VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ 1626
            + + NAA    +++  +   +L +K +Q++    EL ++N   QE L ++ ++L  +   
Sbjct: 1723 LDEANAA----LDSASRLTEQLDVKEEQIE----ELKRQNELRQEMLDDVQKKLMSLANS 1774

Query: 1627 KE 1628
             E
Sbjct: 1775 SE 1776


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  169 bits (428), Expect = 3e-41
 Identities = 296/1353 (21%), Positives = 565/1353 (41%), Gaps = 198/1353 (14%)

Query: 705  EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 764
            +E + LQ  L+EEK + +E   L+ E+E    L Q +A    + +GL + +  E  ++ L
Sbjct: 90   QEVQDLQASLKEEKWYSEE---LKKELEKYQGLQQQEA----KPDGLVTDSSAE--LQSL 140

Query: 765  TQELEQ-----FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
             Q+LE+     F+ +Q+  L E+   +      ++  K+  E +  RE  E +  R T +
Sbjct: 141  EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE-RSLREAAEQKVTRLTEE 199

Query: 820  IEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQ 879
            +  +        TE  +          ++EL  +Q        + E E ++L  EC + Q
Sbjct: 200  LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ 259

Query: 880  ELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLL 939
                    +  ++   ++Q R  L K  +E +   V E Q+L   + +L   ++T    L
Sbjct: 260  S-------QYASSEATISQLRSELAKGPQE-VAVYVQELQKLKSSVNELTQKNQT----L 307

Query: 940  SDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME-N 998
            ++ +L+ +  + +   +  E        E ++ + ++    + D + Q++ S+L A E +
Sbjct: 308  TENLLKKEQDYTKLEEKHNE--------ESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359

Query: 999  IHKATCETADR---------ERAEMSTEISRLQSKIKEMQQAT-----------SPLSML 1038
            +H+   E +++         E +E+ T+   L+++ K++QQ             S ++ L
Sbjct: 360  LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419

Query: 1039 QSGCQVIGEEEVEGDGALSLLQQ--GEQLLEEN---GDVLLSLQRAHEQAVKENVKMATE 1093
             S       +  E  G L   +Q   E+L+++     D+ L L R  EQ +KE V  +TE
Sbjct: 420  HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ-LKEKVTNSTE 478

Query: 1094 ISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRH 1148
               LQ +L K +        L +  T          E  L+Q      + + +E + ++ 
Sbjct: 479  ---LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535

Query: 1149 ------VLSDLEDDEVRDLGSTGTSSV--QRQEVKIEESEASVEGFSELENSEETRTESW 1200
                  +  + ED   +     G ++V  Q QE      E   +   +L+N  E+  ++ 
Sbjct: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 1201 ELKNQISQLQEQLMMLCADCDRASEKK---QDLLFDVSVLKKKLKMLERIPEASPKYKLL 1257
            E  N   Q+QEQ   L A  DR    +    +L   ++  K+K+  L+   +A  +  L 
Sbjct: 596  E--NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653

Query: 1258 YE--------DVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME----E 1305
             E        D+    D  Q  L+  +   ++      ++TA++   Q+   ++E    E
Sbjct: 654  AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713

Query: 1306 VTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEP 1365
              E +LSLE+  +E++ + ++L    L ++   E+  + + Q+            L  + 
Sbjct: 714  YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ----------RQLNTDL 763

Query: 1366 DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH 1425
            +    +L++ LE     V S      + +++++ LE   Q L K +  E   L    +T 
Sbjct: 764  ELRATELSKQLEMEKEIVSSTRL---DLQKKSEALESIKQKLTK-QEEEKQILKQDFETL 819

Query: 1426 QERPRVQNQVILEE-NTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ 1484
             +  ++Q++ +     TT+   Q    + +A + EL   K KL +++  LK         
Sbjct: 820  SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK------ 873

Query: 1485 KDVLSHGEKEEEL-KAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEED 1543
                S  EKE +  KA + DL+ TC E++ ++++    + K Q+E   L+  +    E++
Sbjct: 874  ----SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE---LKKSLE--KEKE 924

Query: 1544 SISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1603
            +   LKL  LN  QE++ Q   T+KQ     Q++  N+ +     + K +Q++    EL 
Sbjct: 925  ASHQLKL-ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983

Query: 1604 ----QKNSQNQEKLQELNQRLTEMLCQKEK--------EPGNSALEE-------REQEKF 1644
                QK     +  Q+L Q   E+  +KEK        E      ++       RE E  
Sbjct: 984  IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043

Query: 1645 NLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQ----ENHLLKDELEKMKQL-HRCP 1699
              +++L+  + + S     L +  +++  Q  ++Q+    +  L +D  +K +QL  RC 
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103

Query: 1700 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1759
             L D Q+         EK LKEKE ++E          KS L E      +QE K     
Sbjct: 1104 ALQDIQK---------EKSLKEKELVNE----------KSKLAEIEEIKCRQE-KEITKL 1143

Query: 1760 SASLKSQLVASQEKVQNLEDT-----VQNVNLQ--MSRMKSDLRVTQQEKEALKQEVMSL 1812
            +  LKS  + S +++ NL+D       Q + LQ     +K+ +   ++ ++ LK +V   
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKE 1203

Query: 1813 HKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT 1872
             ++L+         E     + LH++ K        H  NE +  L  +   L   +   
Sbjct: 1204 EEELKK--------EFIEKEAKLHSEIKEKEVGMKKHEENEAK--LTMQITALNENLGTV 1253

Query: 1873 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQFQKEQ 1925
            K E   S+ +V +LE        +      T+   + E+ +L   C       ++ Q + 
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKV 1313

Query: 1926 SPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1958
                RK+    +  QEL     EN+ L+ K  +
Sbjct: 1314 LELQRKLDNTTAAVQELGR---ENQSLQIKHTQ 1343



 Score =  164 bits (415), Expect = 8e-40
 Identities = 291/1350 (21%), Positives = 568/1350 (42%), Gaps = 241/1350 (17%)

Query: 373  AEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD------HHAAIERRNEYNLR 426
            AE++ L +++++   E   ++   D  E+  + +A+E+ D         ++    E  + 
Sbjct: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 427  KLDEEYKER---IAALKNEL------------RKEREQILQQAGKQRLELEQEIEKAKTE 471
            +L EE  +    I  LK EL            +KE  Q+        LE E+E EK K E
Sbjct: 195  RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254

Query: 472  ENYIRDRLALSLKENSRLENELLENAEKLAEY-----------ENLTNKLQRNLENVLAE 520
               ++ + A S    S+L +EL +  +++A Y             LT K Q   EN+L +
Sbjct: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314

Query: 521  K--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL 578
            +  +  L+    E  + ++ +    ++ +  C+ LQ ++   ++ L     +     L  
Sbjct: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-----LSE 369

Query: 579  KNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDK 638
            K   +++++     +E ++     E   L    E        KEQH        L+L+ +
Sbjct: 370  KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-------KEQH-------GLQLQSE 415

Query: 639  VRHYEKQLDETVVSCKKAQENMKQRHENETHTL---EKQISDLKNEIAELQGQ----AAV 691
            +     +L ET     +A   +K++ +  +  L   E+Q++DL+ +++ L+ Q       
Sbjct: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 692  LKEAHH--EATCRHEEEKKQLQ----VKLEEEKTHLQEKLRL-----QHEMELKARLTQA 740
              E  H  + T +  +E++ LQ     KL E +  L++ LR      Q    L+A L ++
Sbjct: 476  STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535

Query: 741  QAS---FEREREGLQSSAWTEEKVRGLTQELEQFH---QEQLTSLVEK-------HTLEK 787
            + +    E+ERE L +     E    +  +L++ +   QEQ+T L EK       H   +
Sbjct: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 788  EELRKELLEK--HQRELQEGREKMETECNRRTSQIEAQFQSDCQ---KVTERCESALQSL 842
            E L  ++ E+  H R  Q+    +ET  N   SQ+    +   Q   ++  + E  L S 
Sbjct: 596  ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-LLLSA 654

Query: 843  EGRYRQELKDLQ----------EQQREEKSQWEFEKDELTQECAEAQE---LLKETLKRE 889
            E     +  DLQ          + +++E ++   + D++T +  + QE    L+  LK  
Sbjct: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714

Query: 890  KTTSLVLTQEREMLEKTYKE-HLNSMVVE--RQQLLQDLEDLRNVS---ETQQSLLSDQI 943
            K   L L Q+ E LE   K+   +S+ V+  ++Q LQDL+  R ++   E + + LS Q+
Sbjct: 715  KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774

Query: 944  ---LELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 1000
                E+ SS + +L+++ E L      ++L  Q  E+  ++ D E     +K+   E  +
Sbjct: 775  EMEKEIVSSTRLDLQKKSEAL--ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832

Query: 1001 KATCETADRERAEMS-----TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
            +      + ++ +M      TE+S ++ K+ ++  +      L++      +E  +G  A
Sbjct: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS------LKNSKSEFEKENQKGKAA 886

Query: 1056 LSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEIS-RLQQRLQKLEPGLVMSSCL 1114
            +  L++  + L+    V +      ++ +K++++   E S +L+  L  ++  L+ +   
Sbjct: 887  ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ-- 944

Query: 1115 DEPATEFFGNTAEQTEPFLQQ-----NRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1169
                     NT +Q E   QQ     N  KQ     ++ + +   + ++  L  T   + 
Sbjct: 945  ---------NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995

Query: 1170 QRQEV--KIEESEASVEGFSELENSEETRTESW-ELKNQISQLQEQLMMLCADCDRASEK 1226
             +Q++    +E  A  E  S L+N+ E   E++ +L++     + +L+    D     EK
Sbjct: 996  LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055

Query: 1227 ----KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1282
                ++DL+ + + +  + K+++ +  A      L +D +++   LQE  + ++    E 
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAK---ATLEQDSAKKEQQLQERCKALQDIQKEK 1112

Query: 1283 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1342
                KEL        +E  K+ E+ E     EK   E+   NEEL         K+E ++
Sbjct: 1113 SLKEKELV-------NEKSKLAEIEEIKCRQEK---EITKLNEELK------SHKLESIK 1156

Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEG 1402
            E              + NL+   D   L + Q L E   +  S+   +E+ K+  Q L  
Sbjct: 1157 E--------------ITNLK---DAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQIL-- 1196

Query: 1403 NTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELEL 1462
                                         ++QV  EE      F +K  +  + I E E+
Sbjct: 1197 -----------------------------KDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227

Query: 1463 EKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES 1522
               K +E   KL  ++T L             E L  +  + Q      Q++V  L  ++
Sbjct: 1228 GMKKHEENEAKLTMQITAL------------NENLGTVKKEWQ----SSQRRVSELEKQT 1271

Query: 1523 EKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1582
            + L+ E ++L  E T  N +D    L    L G  E      E ++ +   +Q+ ++N  
Sbjct: 1272 DDLRGEIAVL--EATVQNNQDERRALLERCLKGEGE-----IEKLQTKVLELQRKLDNTT 1324

Query: 1583 KQISELKIKNQQLDLENTE-LSQKNSQNQE 1611
              + EL  +NQ L +++T+ L++K +++ E
Sbjct: 1325 AAVQELGRENQSLQIKHTQALNRKWAEDNE 1354



 Score =  157 bits (396), Expect = 1e-37
 Identities = 259/1282 (20%), Positives = 544/1282 (42%), Gaps = 227/1282 (17%)

Query: 847  RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT 906
            RQE++DLQ   +EEK    +  +EL +E  + Q L ++  K +    LV     E+    
Sbjct: 89   RQEVQDLQASLKEEK----WYSEELKKELEKYQGLQQQEAKPD---GLVTDSSAEL---- 137

Query: 907  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA 966
              + L   + E Q    +++ ++++ E + + L+ +I ++KS +  E   RE        
Sbjct: 138  --QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE-------- 187

Query: 967  SEQLASQRLERLEMEHDQER---QEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
                A Q++ RL  E ++E    Q++ ++LL    I          + A +  E+ ++Q+
Sbjct: 188  ---AAEQKVTRLTEELNKEATVIQDLKTELLQRPGI---------EDVAVLKKELVQVQT 235

Query: 1024 KIKEMQ-QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ 1082
             +  M  +       L+  C+ +  +    +  +S L+                      
Sbjct: 236  LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR---------------------- 273

Query: 1083 AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVE 1142
               E  K   E++   Q LQKL+  +   +  ++  TE   N  ++ + + +       E
Sbjct: 274  --SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE---NLLKKEQDYTKLEEKHNEE 328

Query: 1143 GVTRRHVLS-----DLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRT 1197
             V+++++ +     DL+  +++   S   +S+ R  V++ E   + +     E   E  T
Sbjct: 329  SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK--EELSEVET 386

Query: 1198 ESWELKNQISQLQEQLMMLCADCDRASEKKQ---DLLFDVSVLKKKLKMLERIPEASPKY 1254
            +   LK +  QLQ+Q            EK+Q    L  +++ L  KL   ER        
Sbjct: 387  KYQHLKAEFKQLQQQ----------REEKEQHGLQLQSEINQLHSKLLETER-------- 428

Query: 1255 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE 1314
                  +   +  L+E+ ++   +  +  +   +L  ++ RL+++LK  E+VT +   L+
Sbjct: 429  -----QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK--EKVTNS-TELQ 480

Query: 1315 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC----DCCLWEASLENLEIEPDGNIL 1370
               D+ K +++E   L      K+ + Q  + Q      D      +LE L  +   NI 
Sbjct: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 1371 QLNQTLEECVPRVRSVH---HVIEECKQENQYL-EGNTQLLEKVKAHEIAWLHGTIQTHQ 1426
             L +  E+   ++++      V+ + +++N  L E  TQL EK+K           ++H+
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--------ESHK 592

Query: 1427 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELE----KTKLQELTRKLKERVTILV 1482
            +     +  + E+   L   QD+    + ++ EL  +    K K+ +L  ++K +  +L+
Sbjct: 593  QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652

Query: 1483 --------KQKDVLSH--------GEKEEELK----------AMMHDLQITCSEMQQKVE 1516
                    ++ D+ +H         +K++EL           A + D Q  CS+++  ++
Sbjct: 653  SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712

Query: 1517 LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQK 1576
              + +   L+Q+   L  +I  L E DS+       +  S+E+  Q  +  +Q N  ++ 
Sbjct: 713  EYKEKYLSLEQKTEELEGQIKKL-EADSLE------VKASKEQALQDLQQQRQLNTDLEL 765

Query: 1577 MVENLKKQISELK--IKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNS 1634
                L KQ+   K  + + +LDL+         +  E L+ + Q+LT+   ++EK+    
Sbjct: 766  RATELSKQLEMEKEIVSSTRLDLQ---------KKSEALESIKQKLTKQ--EEEKQILKQ 814

Query: 1635 ALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1694
              E   QE     EEL   ++Q++        EL +VK++   +  E   +KD+L K+  
Sbjct: 815  DFETLSQETKIQHEELNN-RIQTTV------TELQKVKMEKEALMTELSTVKDKLSKVSD 867

Query: 1695 LHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQK 1754
                  L + + +        +  + + E   +EL   +    +++L E +   +K+  +
Sbjct: 868  -----SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK--ELKKSLE 920

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
              +  S  LK +L + QE++   ++T++    +  +++ ++   +Q  E  K+++ +L  
Sbjct: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKA 1874
            +L+ A                   QK    +KL   + +  Q L  E E++  +  N + 
Sbjct: 981  ELKIA-----------------VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE- 1022

Query: 1875 ELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQ 1934
                S+E  +QL+S+   +  + L        T Q+  S++ +    Q++      ++  
Sbjct: 1023 ---KSQETFKQLQSDFYGRESELL-------ATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072

Query: 1935 MNSLEQELETIH--LENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQAC 1992
             N L QEL+T    LE +  KK+Q +L E+   +Q ++   +        + +L+ +   
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQ-QLQERCKALQDIQKEKSLK------EKELVNE--- 1122

Query: 1993 PMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK 2052
                + +  +++    + E+    L EEL++   E+     N +    ++ ++ +E++ K
Sbjct: 1123 ----KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178

Query: 2053 LKLVKRLL-QEKVNQ--LKEQV 2071
               +K  + QEK NQ  LK+QV
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQV 1200



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 181/835 (21%), Positives = 341/835 (40%), Gaps = 155/835 (18%)

Query: 1286 NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE--ELNVLVLR-----LQGKI 1338
            N E ++E F     +K +    E F   E  +D         E N+ + R     L+ ++
Sbjct: 33   NNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEV 92

Query: 1339 EKLQESVVQRCDCCLWEAS-----------LENLEIEPDGNILQLNQTLEECVPRVRSVH 1387
            + LQ S+ +      W +            L+  E +PDG +   +  L+       S+ 
Sbjct: 93   QDLQASLKEE----KWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ-------SLE 141

Query: 1388 HVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQ 1447
              +EE + EN  ++    L E+ KA ++A     I++  +  R   +   ++ T L    
Sbjct: 142  QQLEEAQTENFNIKQMKDLFEQ-KAAQLATEIADIKSKYDEERSLREAAEQKVTRLT--- 197

Query: 1448 DKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQIT 1507
                       EL  E T +Q+L  +L +R  I    +DV    ++  +++ +M ++ + 
Sbjct: 198  ----------EELNKEATVIQDLKTELLQRPGI----EDVAVLKKELVQVQTLMDNMTL- 242

Query: 1508 CSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV 1567
              E +++ E L+ E +KLQ + +         + E +IS L+     G QE         
Sbjct: 243  --ERERESEKLKDECKKLQSQYA---------SSEATISQLRSELAKGPQE--------- 282

Query: 1568 KQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1627
                  V   V+ L+K  S +            EL+QKN           Q LTE L +K
Sbjct: 283  ------VAVYVQELQKLKSSVN-----------ELTQKN-----------QTLTENLLKK 314

Query: 1628 EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD 1687
            E++   + LEE+  E+   K+ ++    Q       L++ LS  +   H +  E     +
Sbjct: 315  EQD--YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372

Query: 1688 ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSE---ELNSCVDKLAKSSLLEH 1744
              +K+K+     +LS+ + K   + +  ++L +++E   +   +L S +++L  S LLE 
Sbjct: 373  ATQKLKE-----ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL-HSKLLE- 425

Query: 1745 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR--VTQ--- 1799
                    ++        LK Q   S EK+ + E  V ++ L++SR++  L+  VT    
Sbjct: 426  -------TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478

Query: 1800 ------------QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL 1847
                        QE++AL+Q   +  ++ QN   +    +I      + N +  L   K 
Sbjct: 479  LQHQLDKTKQQHQEQQALQQSTTAKLREAQN-DLEQVLRQIGDKDQKIQNLEALLQKSK- 536

Query: 1848 DHLMNEEQQLLWQENERLQTMVQNTKAE---LTHSREKVRQLESNLLPKHQKHLNPSGTM 1904
                 E   LL +E E L   +Q  + E   L   +EK   L+  +    +K  N S   
Sbjct: 537  -----ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS--- 588

Query: 1905 NPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM 1964
               E  K + +   DQ Q++++       ++ SLE  +  ++ +    K+K  +LD Q+ 
Sbjct: 589  ---ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645

Query: 1965 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE----- 2019
                L  +A  + +    DLQ     A   +  +Q  +L +   Q +++   LQ+     
Sbjct: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ-QELNKITTQLDQVTAKLQDKQEHC 704

Query: 2020 -ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
             +LE+   E      + EQ    +E ++ ++E     VK   ++ +  L++Q  L
Sbjct: 705  SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  167 bits (423), Expect = 1e-40
 Identities = 345/1694 (20%), Positives = 696/1694 (41%), Gaps = 259/1694 (15%)

Query: 375  IRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKE 434
            + H  ER+    RE + LR +L+K      L A    +    I +     ++      KE
Sbjct: 61   LSHSQERLVNETRECQSLRLELEKLNN--QLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118

Query: 435  RIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKE------NSR 488
             + A K +L +  E++ Q+      ++++  EK K E N  +  L L L E      + +
Sbjct: 119  ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK-ESNTTKGELQLKLDELQASDVSVK 177

Query: 489  LENELLENAEKLAEYEN--LTNKLQRNLENVLA---EKFGDLDPSSAEFFLQEE---RLT 540
               + LE  ++L   +N  L  +L+   + +LA   EK  ++         ++E   RL 
Sbjct: 178  YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237

Query: 541  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKN-------------SPSEEVE 587
            +  N  +     LQ  V++L ++L+E + Q   +     N             S +++ E
Sbjct: 238  EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297

Query: 588  ANSG----GIEPEHGLGSEECNPLNMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHY 642
            A S      +E  H L  +E    N +I+  L+ +EQ K+Q  +       E+ +K+   
Sbjct: 298  AKSNELTRAVEELHKL-LKEAGEANKAIQDHLLEVEQSKDQMEK-------EMLEKIGRL 349

Query: 643  EKQLDETVVSCKKAQENMKQRHENETHTLEK-------------QISDLKNEIAELQGQA 689
            EK+L+         +       E E   +               ++++L N   E Q Q 
Sbjct: 350  EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409

Query: 690  AVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEM-ELKARLTQAQASFERER 748
             + K  +       +E  K+++ K    K   +E  R Q  +  L  +L QA    +R +
Sbjct: 410  LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469

Query: 749  EGL-----QSSAWTEE-------------KVRGLTQELEQ------FHQEQLTS------ 778
            E       QSS    +             ++R L  ELE+         E+++S      
Sbjct: 470  EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529

Query: 779  --LVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTE--- 833
              ++ +H +    + +EL +++QR L   RE  ET    R  Q     ++   K+TE   
Sbjct: 530  SEVISQHLVSYRNI-EELQQQNQRLLVALRELGETR--EREEQ-----ETTSSKITELQL 581

Query: 834  RCESALQSLEG--RYRQELKDLQEQQREEKSQWEFEKDELTQECA--EAQEL----LKET 885
            + ESAL  LE   + RQ    L +    ++  +     + T       A  L    L  T
Sbjct: 582  KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641

Query: 886  LKREKTTSLVLTQER-EMLEKTYKEHLNSMVVERQQLLQDLE----DLRNVSETQQSLLS 940
             KR  T+  V T     ++E T      + + + Q++ ++ +    +   +   Q   L 
Sbjct: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701

Query: 941  DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 1000
            +Q+ +L+S + +   + +            AS+R E L+   +  R+E+ S     E   
Sbjct: 702  EQVTDLRSQNTKISTQLD-----------FASKRYEMLQDNVEGYRREITS---LHERNQ 747

Query: 1001 KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLL 1059
            K T  T  +E+         + +  ++++ A   L++ +   + + +E E+     + L 
Sbjct: 748  KLTATTQKQEQI--------INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLS 799

Query: 1060 QQGEQLL-EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV-MSSCLDEP 1117
            QQ E LL E+ G  LL       Q + E  +  T+  RL  +++KLE  +  +   L+  
Sbjct: 800  QQRESLLAEQRGQNLLLTNLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858

Query: 1118 ATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHV-LSDLEDDEVRDLGSTGTSSVQRQEVKI 1176
              +    T       L   R  Q++  T  H+   +L  +  +++ +T    +   EV++
Sbjct: 859  VEQRHTLTRNLDVQLLDTKR--QLDTETNLHLNTKELLKNAQKEI-ATLKQHLSNMEVQV 915

Query: 1177 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1236
                +   G  +  N E+      +L +Q+ Q +EQ+          ++ K+ L    S 
Sbjct: 916  ASQSSQRTGKGQPSNKEDVD----DLVSQLRQTEEQV----------NDLKERLKTSTSN 961

Query: 1237 LKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRL 1296
            +++   M+  + E+  K K + E+V +  +   +E    +T+ ++ L    E+  E   L
Sbjct: 962  VEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL---MEVEKEKQEL 1018

Query: 1297 QDELKKMEEVTETFLS-LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWE 1355
            QD+ ++  E  E  LS L+K+   V+ E +E            ++ +    ++    +  
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078

Query: 1356 ASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEI 1415
             +    E+      ++  Q  +E V ++ SV   +EE  Q+ +     +QLLE     + 
Sbjct: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE-----SQLLEC----KA 1129

Query: 1416 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLK 1475
            +W        +ER R+               +D+  +      +LE +   L +   KL 
Sbjct: 1130 SW--------EERERM--------------LKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167

Query: 1476 ERVTILVKQK-------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE 1528
            ++V   VK+         +   G+ +E++  ++  ++      + + E+ + ES + +Q 
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227

Query: 1529 NSILRNEITTLNEEDSISNLKL---GTLNGSQEEMWQKTET---VKQENAAVQKMVENLK 1582
              +L  E+  L +  +    K+          EE+ +KTET   V + N  +++  E L+
Sbjct: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE 1287

Query: 1583 KQISELKIKNQQLDLE-------NTELSQKNS--QNQEKLQE--------LNQRLTEMLC 1625
            + + +++ K ++L+L+       N ELS+K+   Q ++KL E         NQ L     
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347

Query: 1626 QKEKEPGNSALEERE----------QEKFNLKEELERCKVQ---SSTLVSSLEAELSEVK 1672
              + E     L E+E          +E   LK E+ R       +  L+ SL+ +L++V+
Sbjct: 1348 DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVR 1407

Query: 1673 IQTHIVQQE-NHLLKDELEKMKQLHRCPDLSD-FQQKISSVLSYNEKLLKEKEALSEELN 1730
             +   +Q++ +  + D  EK+K + +   +   ++ +   + +  +K+++     S +  
Sbjct: 1408 TEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQ 1467

Query: 1731 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1790
                 + +   L+  +   + + KS E Q  +L+  L   + + +NL++    +  ++SR
Sbjct: 1468 EQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527

Query: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNA--GGKSWAPEIATHPSGLHNQQKRLSWDKLD 1848
            ++ DL+    ++E L+Q++    ++ + A    KS   +IA H +G+ +Q       K +
Sbjct: 1528 LRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS---KIA-HLAGVKDQ-----LTKEN 1578

Query: 1849 HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL-------NPS 1901
              + +    L Q+ + L   +   K++      ++ +LE  L    ++HL        PS
Sbjct: 1579 EELKQRNGALDQQKDELDVRITALKSQY---EGRISRLERELREHQERHLEQRDEPQEPS 1635

Query: 1902 GTMNPTEQEKLSLK 1915
              + P +Q +++LK
Sbjct: 1636 NKV-PEQQRQITLK 1648



 Score =  150 bits (379), Expect = 1e-35
 Identities = 321/1628 (19%), Positives = 677/1628 (41%), Gaps = 278/1628 (17%)

Query: 632  RLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 691
            R EL    +  + +L++ +   +   + +K RHE      E+Q  +++  ++    Q  +
Sbjct: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS--HSQERL 68

Query: 692  LKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGL 751
            + E     + R E EK   Q+K   EK + + ++     + ++++ T+ +   E E+  L
Sbjct: 69   VNETRECQSLRLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127

Query: 752  --------QSSAWTEEKVRGLTQELEQ-----------FHQEQLTSLVEKHTLEKEELRK 792
                    Q   +  E V+ L ++L++             + Q + +  K+  ++ E  K
Sbjct: 128  IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187

Query: 793  ELLEKHQREL----------------QEGREKMETECN-----RRTSQIEAQF------Q 825
            ELL      L                ++G E +E +CN        S++E Q        
Sbjct: 188  ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN 247

Query: 826  SDCQKVTERCESALQ-------SLEGRYRQELK---DLQEQQREEKSQWEFEKDELTQEC 875
               QK  E   + L+       S+E ++  EL     L    +      E + +ELT+  
Sbjct: 248  EHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAV 307

Query: 876  AEAQELLKETLKREKTTSLVLTQ--------EREMLEKTYK-----EHLNSMV--VERQQ 920
             E  +LLKE  +  K     L +        E+EMLEK  +     E+ N ++   +R+ 
Sbjct: 308  EELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367

Query: 921  LLQDLEDLRNVSETQQSL-------------------LSDQILELKSSHKRELREREEVL 961
             +   E+L  +S T  ++                     DQ+L  K  +KR  +  +E++
Sbjct: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427

Query: 962  CQAGASEQLASQRLERLEMEHDQERQEMMSKLL--AMENIHKATCET--ADRERAEMSTE 1017
             +  A   +  +  +R E E  Q+    +S  L  AM+ I +   +T  A+++ + +  +
Sbjct: 428  KEVEAKAPILKR--QREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485

Query: 1018 ISRLQSKIKEMQQATSPLSM---LQSGCQVIGEEEVEG---DGALSLLQQG-------EQ 1064
              R++ ++K++ Q    L M      G  VI +EEV       +  ++ Q        E+
Sbjct: 486  NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545

Query: 1065 LLEENGDVLLSLQRAHEQAVKENVK-MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFG 1123
            L ++N  +L++L+   E   +E  +  +++I+ LQ +L+     L       +   +   
Sbjct: 546  LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605

Query: 1124 NTAEQTEPF-LQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1182
            +   Q + + +  ++T  V        L D+         ST  +      V + ES  +
Sbjct: 606  SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665

Query: 1183 VEGFSEL-------ENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDV 1234
            +E  + L       EN ++ + E+ +++N Q+ +LQEQ+  L     R+   K     D 
Sbjct: 666  IEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL-----RSQNTKISTQLDF 720

Query: 1235 SVLKKKLKML-ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEV 1293
            +   K+ +ML + +     +   L+E   +     Q++ +++ T   +    N++L    
Sbjct: 721  A--SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778

Query: 1294 FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL---QGKIEKLQESVVQRCD 1350
             R ++  K+ E +  + + L +  + +  E    N+L+  L   QG +E+ +    QR  
Sbjct: 779  VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL- 837

Query: 1351 CCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE---NQYLEGNTQLL 1407
                 + +E LE E      +L   +E+     R++   + + K++      L  NT+ L
Sbjct: 838  ----SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL 1467
             K    EIA    T++ H     VQ   +  +++   G       ++  + +L  +  + 
Sbjct: 894  LKNAQKEIA----TLKQHLSNMEVQ---VASQSSQRTGKGQP--SNKEDVDDLVSQLRQT 944

Query: 1468 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527
            +E    LKER+          +     E+ +AM+  L+ + ++ +Q  E +R   E   +
Sbjct: 945  EEQVNDLKERLK---------TSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK 995

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
            E++  + ++     E      +L      Q++  +  E+++Q+ + ++K + +++ ++ E
Sbjct: 996  ESAEFQTQLEKKLMEVEKEKQEL------QDDKRRAIESMEQQLSELKKTLSSVQNEVQE 1049

Query: 1588 LKIKNQQLDLENTELSQKNSQNQEKL--QELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1645
              ++     L N + ++++ Q Q K+  +  N+   E++          A +E+  +  +
Sbjct: 1050 -ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS 1108

Query: 1646 LKEELE-----------RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM-- 1692
            +++ LE            CK         L+ E+S+   +   ++++N LL D++EK+  
Sbjct: 1109 VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168

Query: 1693 ------KQLHRCP---DLSD---FQQKISSVLSY--NEKLLKEK---------------- 1722
                  K+  + P    LS+    Q++I  +L +   EK + E                 
Sbjct: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRV 1228

Query: 1723 EALSEELNSCVDKL-AKSSLLEHRIATMKQEQ---KSWEHQSASLKSQLVASQEKVQNLE 1778
            E L  EL    D L A+   ++    TM Q +   K  E  +  +++  +  +EK + LE
Sbjct: 1229 ELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK-ERLE 1287

Query: 1779 DTVQNVNLQMSRMKSDLRVTQQEKEAL--KQEVMSLHKQLQNAGGKSWAPEIATHPSGLH 1836
              +Q +  ++ +++ D+   Q+    L  K  ++   K+L     K W          L 
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRW----KARNQHLV 1343

Query: 1837 NQQKRLSWDKLDHLMNEEQ------QLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1890
            +QQK    ++   L++E++      Q L +E  RL+  +  + A LT+++  ++ L+ +L
Sbjct: 1344 SQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDL 1403

Query: 1891 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE 1950
                          N    EK +++++ D    +     + ++Q+  + +  +T   + E
Sbjct: 1404 --------------NKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT---QYE 1446

Query: 1951 GLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQA 2010
             LK +Q K+ E          T+  S   H       Q+Q    V  ++  +L+  L QA
Sbjct: 1447 ELKAQQDKVME----------TSAQSSGDH-------QEQ---HVSVQEMQELKETLNQA 1486

Query: 2011 ERINQHLQEELEN---RTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKV--- 2064
            E  ++ L+ ++EN     SE  T   N       ++E+ ++++ +L  +++ LQ++    
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARN-------LQEQTVQLQSELSRLRQDLQDRTTQE 1539

Query: 2065 NQLKEQVS 2072
             QL++Q++
Sbjct: 1540 EQLRQQIT 1547



 Score =  146 bits (368), Expect = 2e-34
 Identities = 315/1590 (19%), Positives = 659/1590 (41%), Gaps = 251/1590 (15%)

Query: 634  ELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE-----LQGQ 688
            E+E ++ H +++L      C+  +  +++ + N+   L ++  +L  EIA+     +Q Q
Sbjct: 56   EIEKRLSHSQERLVNETRECQSLRLELEKLN-NQLKALTEKNKEL--EIAQDRNIAIQSQ 112

Query: 689  AAVLKE---AHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEM--ELKARLTQAQAS 743
                KE   A      R  E   Q    L E+   L EKL+  +    EL+ +L + QAS
Sbjct: 113  FTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS 172

Query: 744  ----------FEREREGLQS-SAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTLEKEELR 791
                       E+E+E L S + W   +++  T EL    +E+   ++E K  LE ++  
Sbjct: 173  DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE 232

Query: 792  KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELK 851
               LE+    L+   E ++       ++++   +               S+E ++  EL 
Sbjct: 233  VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA------------SMEEKFHNELN 280

Query: 852  ---DLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ--------ER 900
                L    +      E + +ELT+   E  +LLKE  +  K     L +        E+
Sbjct: 281  AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340

Query: 901  EMLEKTYK-----EHLNSMV--VERQQLLQDLEDLRNVSETQQSLLS------------- 940
            EMLEK  +     E+ N ++   +R+  +   E+L  +S T  ++               
Sbjct: 341  EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400

Query: 941  ------DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL 994
                  DQ+L  K  +KR  +  +E++ +  A   +  ++ E  E E  Q+    +S  L
Sbjct: 401  AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQRE--EYERAQKAVASLSVKL 458

Query: 995  --AMENIHKATCET--ADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS---GCQVIGE 1047
              AM+ I +   +T  A+++ + +  +  R++ ++K++ Q    L M      G  VI +
Sbjct: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518

Query: 1048 EEVEG---DGALSLLQQG-------EQLLEENGDVLLSLQRAHEQAVKENVKM-ATEISR 1096
            EEV       +  ++ Q        E+L ++N  +L++L+   E   +E  +  +++I+ 
Sbjct: 519  EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITE 578

Query: 1097 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
            LQ +L+     L       +   +   +   Q + +  +    Q  GV      S L+D 
Sbjct: 579  LQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMY--RILLSQTTGVAIPLHASSLDDV 636

Query: 1157 EVRDLG---STGTSSVQRQEVKIEESEASVEGFSEL-------ENSEETRTESWELKN-Q 1205
             +       ST  +      V + ES  ++E  + L       EN ++ + E+ +++N Q
Sbjct: 637  SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ 696

Query: 1206 ISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-YKLLYEDVSRE 1264
            + +LQEQ+  L     R+   K     D +   K+ +ML+   E   +    L+E   + 
Sbjct: 697  LEKLQEQVTDL-----RSQNTKISTQLDFA--SKRYEMLQDNVEGYRREITSLHERNQKL 749

Query: 1265 NDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIEN 1324
                Q++ +++ T   +    N++L     R ++  K+ E +  + + L +  + +  E 
Sbjct: 750  TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQ 809

Query: 1325 EELNVLVLRLQ---GKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVP 1381
               N+L+  LQ   G +E+ +    QR       + +E LE E      +L   +E+   
Sbjct: 810  RGQNLLLTNLQTIQGILERSETETKQRLS-----SQIEKLEHEISHLKKKLENEVEQRHT 864

Query: 1382 RVRSVHHVIEECKQE---NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE 1438
              R++   + + K++      L  NT+ L K    EIA    T++ H     VQ   +  
Sbjct: 865  LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA----TLKQHLSNMEVQ---VAS 917

Query: 1439 ENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELK 1498
            +++   G       ++  + +L  +  + +E    LKER+          +     E+ +
Sbjct: 918  QSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLKERLK---------TSTSNVEQYQ 966

Query: 1499 AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE 1558
            AM+  L+ + ++ +Q  E +R   E   +E++  + ++     E      +L      Q+
Sbjct: 967  AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL------QD 1020

Query: 1559 EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL--QEL 1616
            +  +  E+++Q+ + ++K + +++ ++ E  ++     L N + ++++ Q Q K+  +  
Sbjct: 1021 DKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQAKIAVEAQ 1079

Query: 1617 NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER-----------CKVQSSTLVSSLE 1665
            N+   E++          A +E+  +  ++++ LE            CK         L+
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139

Query: 1666 AELSEVKIQTHIVQQENHLLKDELEKM--------KQLHRCP---DLSD---FQQKISSV 1711
             E+S+   +   ++++N LL D++EK+        K+  + P    LS+    Q++I  +
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199

Query: 1712 LSY--NEKLLKEK----------------EALSEELNSCVDKL-AKSSLLEHRIATMKQE 1752
            L +   EK + E                 E L  EL    D L A+   ++    TM Q 
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQH 1259

Query: 1753 Q---KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQE- 1808
            +   K  E  +  +++  +  +EK + LE  +Q +  ++ +++ D+   Q+    L ++ 
Sbjct: 1260 EELMKKTETMNVVMETNKMLREEK-ERLEQDLQQMQAKVRKLELDILPLQEANAELSEKS 1318

Query: 1809 -VMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQ------QLLWQE 1861
             ++   K+L     K W          L +QQK    ++   L++E++      Q L +E
Sbjct: 1319 GMLQAEKKLLEEDVKRWK----ARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374

Query: 1862 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQF 1921
              RL+  +  + A LT+++  ++ L+ +L              N    EK +++++ D  
Sbjct: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDL--------------NKVRTEKETIQKDLDAK 1420

Query: 1922 QKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ-----------LMEMQHLR 1970
              +     + ++Q+  + +  +T + E +  + K ++   Q           + EMQ L+
Sbjct: 1421 IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELK 1480

Query: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNT 2030
             T             L Q +        Q   LQ+ L + E   ++LQE+     SE + 
Sbjct: 1481 ET-------------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527

Query: 2031 PQGNQEQLVTVMEERMIEVEQKLKLVKRLL 2060
             + + +   T  E+   ++ +K +  ++ +
Sbjct: 1528 LRQDLQDRTTQEEQLRQQITEKEEKTRKAI 1557



 Score =  116 bits (291), Expect = 2e-25
 Identities = 217/1055 (20%), Positives = 461/1055 (43%), Gaps = 169/1055 (16%)

Query: 313  VERILDTWQEEGIEN----SQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAAL 368
            ++ I + +++E  EN    ++++ K  +   D     T+++  L+      +  + Q  +
Sbjct: 675  LQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLD--FASKRYEMLQDNV 732

Query: 369  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV---DDHHAAIERRNEYNL 425
              ++ EI  L ER        +KL +   K E++ + M  ++   ++  A  E R E NL
Sbjct: 733  EGYRREITSLHER-------NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAE-NL 784

Query: 426  RKLDEEYKERIAALKNELRKEREQILQQAGKQRLEL------EQEIEKAKTEENYIRDRL 479
            +K     KE +   +  L ++RE +L +   Q L L      +  +E+++TE    + RL
Sbjct: 785  KK----EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET---KQRL 837

Query: 480  ALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERL 539
            +  ++   +LE+E+    +KL       + L RNL+  L +    LD  +      +E L
Sbjct: 838  SSQIE---KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894

Query: 540  TQMRNEYERQCRVL----------------------QDQVDELQSELEEYRAQGRVLRLP 577
               + E     + L                      ++ VD+L S+L +   Q   L+  
Sbjct: 895  KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954

Query: 578  LKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELED 637
            LK S S   +  +     E  L  E+               Q+ E+  ++I    + L++
Sbjct: 955  LKTSTSNVEQYQAMVTSLEESLNKEK---------------QVTEEVRKNI---EVRLKE 996

Query: 638  KVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 697
                ++ QL++ ++  +K ++ ++        ++E+Q+S+LK  ++ +Q +   ++EA  
Sbjct: 997  SAE-FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE---VQEALQ 1052

Query: 698  EATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 757
             A+     E++  +   E+ K  ++ + + + E+ L A   +A    +  +E +   A  
Sbjct: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEA---LQAAKEQVSKMASV 1109

Query: 758  EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRK-----ELLEKHQRELQEGREKMETE 812
             + +   TQ+ E    E   S  E+  + K+E+ K     E LEK  R L +  EK+   
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS-- 1167

Query: 813  CNRRTSQIEAQFQSDCQ-KVTERCESALQSLE-GRYRQELKDLQEQQRE----EKSQWEF 866
             ++  + ++   Q      ++E  +S  Q LE  R+ +  K++ E + E    E  ++  
Sbjct: 1168 -DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226

Query: 867  EKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHL----NSMV-VERQQL 921
              + L +E  E Q+ L    ++ + T+  + Q  E+++KT   ++    N M+  E+++L
Sbjct: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERL 1286

Query: 922  LQDLEDLR-NVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM 980
             QDL+ ++  V + +  +L  Q    + S K  + + E+ L +       A  R + L  
Sbjct: 1287 EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA--RNQHLVS 1344

Query: 981  EHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
            +      E   KLL+ + +H    +       +++ EI RL++   E+ ++ + L+  Q+
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQ-------QLTEEIGRLKA---EIARSNASLTNNQN 1394

Query: 1041 GCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR 1100
              Q + E+       L+ ++  ++ ++++ D  +         ++E VK  T++ ++ +R
Sbjct: 1395 LIQSLKED-------LNKVRTEKETIQKDLDAKII-------DIQEKVKTITQVKKIGRR 1440

Query: 1101 LQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRD 1160
             +                T++    A+Q +       + Q  G  +   +S  E  E+++
Sbjct: 1441 YK----------------TQYEELKAQQDK---VMETSAQSSGDHQEQHVSVQEMQELKE 1481

Query: 1161 LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADC 1220
                   ++ + E K +  E+ VE   +  + +E  TE+  L+ Q  QLQ +L  L  D 
Sbjct: 1482 -------TLNQAETKSKSLESQVENLQKTLSEKE--TEARNLQEQTVQLQSELSRLRQDL 1532

Query: 1221 -DRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLL---YEDVSRENDCLQEELRMME 1276
             DR ++++Q       + +K+ K  + I  A  K   L    + +++EN+ L++    ++
Sbjct: 1533 QDRTTQEEQ---LRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589

Query: 1277 TRYDE------ALENNKELTAEVFRLQDELKKMEE 1305
             + DE      AL++  E    + RL+ EL++ +E
Sbjct: 1590 QQKDELDVRITALKSQYE--GRISRLERELREHQE 1622



 Score = 88.2 bits (217), Expect = 8e-17
 Identities = 205/1023 (20%), Positives = 409/1023 (39%), Gaps = 143/1023 (13%)

Query: 1157 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLM 1214
            E  +L     S   + E  + + ++ ++G        +  +E   +E++ ++S  QE+L+
Sbjct: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69

Query: 1215 MLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRM 1274
                +C     + + L   +  L +K K LE   + +   +  +     E +  + +L  
Sbjct: 70   NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129

Query: 1275 METRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
               R  + LE    LT +V RL ++LK   E   T   L+   DE++  +  +     RL
Sbjct: 130  TNERLSQELE---YLTEDVKRLNEKLK---ESNTTKGELQLKLDELQASDVSVKYREKRL 183

Query: 1335 QGKIEKL-QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1393
            + + E L  ++     +       L  L  E    IL+L   LE     V  +   +   
Sbjct: 184  EQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243

Query: 1394 KQENQYLEGNTQ-LLEKVK------------------AH-EIAWLHGTIQTHQERPRVQN 1433
            K  N++L+ + + LL K+K                  AH +++ L+ +     E    + 
Sbjct: 244  KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303

Query: 1434 QVILEENTTLL---GFQDKHFQHQATIAEL---ELEKTKLQELTRKLKERVTILVKQKDV 1487
               +EE   LL   G  +K  Q      E    ++EK  L+++ R  KE    L    D+
Sbjct: 304  TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE----LENANDL 359

Query: 1488 LSHGEK------EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT--- 1538
            LS  ++      EEEL AM          ++  ++L    +  ++ ++ +L  ++     
Sbjct: 360  LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI 419

Query: 1539 ---LNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1595
               L+E       K   L   +EE     E  ++  A++   +E   K+I  L+    + 
Sbjct: 420  NKYLDEIVKEVEAKAPILKRQREEY----ERAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475

Query: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1655
            + +++ L + N + + ++++L+Q++  +L + E+  GN  + + E    ++    E   V
Sbjct: 476  NKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE---V 532

Query: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN 1715
             S  LVS    E  + + Q  +V      L +  E+ +Q      +++ Q K+ S L+  
Sbjct: 533  ISQHLVSYRNIEELQQQNQRLLVALRE--LGETREREEQETTSSKITELQLKLESALTEL 590

Query: 1716 EKLLKEKEALSEELNSCVDK-----------------LAKSSLLEHRIAT---------- 1748
            E+L K ++   + ++S V +                 L  SSL +  +A+          
Sbjct: 591  EQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQT 650

Query: 1749 ---------------------MKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1787
                                 +KQ Q+ +E+             E+++ L++ V ++  Q
Sbjct: 651  VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQ 710

Query: 1788 MSRMKSDL-------RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPE--IATHPSGLHNQ 1838
             +++ + L        + Q   E  ++E+ SLH++ Q     +   E  I T    L   
Sbjct: 711  NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770

Query: 1839 QKRLSWDKL--DHLMNEEQQL------LWQENERLQTMVQNTKAELTHSREKVRQLESNL 1890
             ++L+  ++  ++L  E++ L      L Q+ E L    +     LT+ +     LE + 
Sbjct: 771  NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE 830

Query: 1891 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVS-QMNSLEQELET---IH 1946
                Q+    S  +   E E   LK++ +   +++    R +  Q+   +++L+T   +H
Sbjct: 831  TETKQR---LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLH 887

Query: 1947 LENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQ 2006
            L  + L K   K  E     QHL +      S  +      Q        +E    L  Q
Sbjct: 888  LNTKELLKNAQK--EIATLKQHLSNMEVQVASQSSQRTGKGQPS-----NKEDVDDLVSQ 940

Query: 2007 LLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQ 2066
            L Q E     L+E L  +TS +N  Q   + +VT +EE + + +Q  + V++ ++ ++ +
Sbjct: 941  LRQTEEQVNDLKERL--KTSTSNVEQ--YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKE 996

Query: 2067 LKE 2069
              E
Sbjct: 997  SAE 999



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 72/347 (20%), Positives = 146/347 (42%), Gaps = 56/347 (16%)

Query: 1757 EHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLR-VTQQEKEALKQEVMSLHKQ 1815
            E Q   ++ +L  SQE++ N     Q++ L++ ++ + L+ +T++ KE    +  ++  Q
Sbjct: 51   EQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQ 110

Query: 1816 LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAE 1875
             Q    K    E+      L    +RLS  +L++L  + ++L    NE+L+     TK E
Sbjct: 111  SQFTRTKE---ELEAEKRDLIRTNERLS-QELEYLTEDVKRL----NEKLKES-NTTKGE 161

Query: 1876 L-------------THSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-DQF 1921
            L                REK  + E  LL      LN    +     E L+L RE  ++ 
Sbjct: 162  LQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTE--LKTKTDELLALGREKGNEI 219

Query: 1922 QKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHA 1981
             + +     K  +++ LE+++  +   NE L+K    L  +L E +              
Sbjct: 220  LELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAK-------------- 265

Query: 1982 WDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVT- 2040
                  +QQA      E+F       ++   + +   ++ E +++E         +L+  
Sbjct: 266  ------EQQASM---EEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKE 316

Query: 2041 ------VMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPT 2081
                   +++ ++EVEQ    +++ + EK+ +L++++     L S T
Sbjct: 317  AGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 38/152 (25%)

Query: 322  EEGIENSQEILKALDFSLDGNINLTELTLALENEL--------------------LVTKN 361
            E  +EN Q+ L   +       NL E T+ L++EL                    +  K 
Sbjct: 1494 ESQVENLQKTLSEKETEAR---NLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE 1550

Query: 362  SIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRN 421
               + A+ + K++I HL    DQ+ +E E+L+      ++ K  +               
Sbjct: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL--------------- 1595

Query: 422  EYNLRKLDEEYKERIAALKNELRKEREQILQQ 453
            +  +  L  +Y+ RI+ L+ ELR+ +E+ L+Q
Sbjct: 1596 DVRITALKSQYEGRISRLERELREHQERHLEQ 1627


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  163 bits (412), Expect = 2e-39
 Identities = 378/1794 (21%), Positives = 731/1794 (40%), Gaps = 293/1794 (16%)

Query: 332  LKALDFSLDG-NINLTELTLALEN-ELLVTKNSIHQAALASFKAEIRHLLERVDQVVREK 389
            L+  + SLD  N  L +L   L N EL + ++   +  L      IR  LE  +    + 
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQS 1255

Query: 390  EKLRS----DLDKAEKLKS----LMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 441
            +++      ++D  EK  S    L  S+ D+ H     +   N     E+  E + A K 
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKY 1315

Query: 442  ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 501
            EL  E      +      ++ +E+ K   E   + D       ++  L  EL+E+     
Sbjct: 1316 ELVTELNDSRSECITATRKMAEEVGKLLNEVKILND-------DSGLLHGELVEDIPG-G 1367

Query: 502  EYENLTNKLQRNLENVLAEK--FGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ--- 556
            E+    N+        L E   +  L  S  E  +    L +     + + ++L DQ   
Sbjct: 1368 EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ 1427

Query: 557  ----VDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG---SEECNPLNM 609
                + ELQ+ ++  +A+  VL   L+N   + V+    G+  E GL    S  C P + 
Sbjct: 1428 MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL--EEGLVPSLSSSCVPDSS 1485

Query: 610  SIEA-------ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 662
            S+ +         ++EQ  +        L   LE  V   +  +DE  V C   QE    
Sbjct: 1486 SLSSLGDSSFYRALLEQTGDM------SLLSNLEGAVSANQCSVDE--VFCSSLQEENLT 1537

Query: 663  RHENET-----------------HTLEKQISDLKNE----IAELQGQAAVLKEAHHEATC 701
            R E  +                  +LEK    ++++      E+Q    +L     E  C
Sbjct: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC 1597

Query: 702  RHEE---EKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW-- 756
              ++   E +Q Q KL      ++ KL  + +   +  L    A  + +   L S +   
Sbjct: 1598 LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLG 1657

Query: 757  --TEEKVRGLTQ--ELEQFHQEQLTSLVEKHTLEK---EELRKELLEKHQRELQEGREKM 809
              TE+ ++G  +  ++ + H  + T    KH + +   ++ +++L    ++  + G  K 
Sbjct: 1658 IDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKP 1717

Query: 810  ETECNRRTS---------QIEAQFQSDC----------------------------QKVT 832
              EC+   S         + + Q  S+C                             +V 
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK 1777

Query: 833  ERCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDEL---TQECAEAQELLKETL 886
            E     L+ L   E R R +++ L  + +E  S+   ++ +L    + C E ++++ E L
Sbjct: 1778 ETSNENLRLLHVIEDRDR-KVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGE-L 1835

Query: 887  KREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 946
            K+E +    L+++ E     ++E L   V   + L  DLE   +  ++ +  + D + ++
Sbjct: 1836 KKENSD---LSEKLEYFSCDHQE-LLQRVETSEGLNSDLE--MHADKSSREDIGDNVAKV 1889

Query: 947  KSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHK-ATCE 1005
              S K    + E  L +  + +  AS   E L +E D E  +     L  +N +K     
Sbjct: 1890 NDSWKERFLDVENELSRIRSEK--ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947

Query: 1006 TADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGDGALSLLQQGEQ 1064
              + E + +++E ++L+ ++  M + T+ L  L    +   +E E      L  +Q  E 
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007

Query: 1065 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGN 1124
             ++E  ++L +L       V E +K  T +    Q L+K    L ++ C           
Sbjct: 2008 EVKEKTELLQTL----SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC----------- 2052

Query: 1125 TAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVE 1184
              E      Q N+ K++       + + L + +   L      S   +   +E+ E ++ 
Sbjct: 2053 --ELENQIAQLNKEKELLVKESESLQARLSESDYEKL----NVSKALEAALVEKGEFALR 2106

Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFD-VSVLKKKLKM 1243
              S  E   + R    +L+ +I +  E+  +  A+  +  E++ D L D V  L+++L+M
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRI-EADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165

Query: 1244 LERIPEA----SPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDE 1299
             E   E     +   K   E +  + + +   L++ E          + LT ++   Q +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ 2225

Query: 1300 LKKMEEVTETFLSL--EKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRC-DCCLWEA 1356
            L +++++  +F SL  EK   E++I+ EE    V  LQ ++++L E+V   C D  + +A
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIK-EESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284

Query: 1357 SLENLE--IEPD----GNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKV 1410
            + ++L+  IE +     +I +L   LE    +   V   ++E +     L+G  + LE  
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-- 2342

Query: 1411 KAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQEL 1470
            +  EIA      +T+QE   ++      EN+                 E+E  K K++ +
Sbjct: 2343 RELEIA------RTNQEHAALE-----AENSK---------------GEVETLKAKIEGM 2376

Query: 1471 TRKLK----ERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQ 1526
            T+ L+    + VTI  +++++ +  +KE+E    + +L+I  S  +  ++    E  +++
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQE---RISELEIINSSFENILQEKEQEKVQMK 2433

Query: 1527 QENS----ILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLK 1582
            +++S    +L+ ++  LNE       ++  L+  QE              A +   +NL 
Sbjct: 2434 EKSSTAMEMLQTQLKELNE-------RVAALHNDQE--------------ACKAKEQNLS 2472

Query: 1583 KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQE 1642
             Q+       + L+LE  +L Q   + +     L   +  ++  +E E G   LE++++E
Sbjct: 2473 SQV-------ECLELEKAQLLQGLDEAKNNYIVLQSSVNGLI--QEVEDGKQKLEKKDEE 2523

Query: 1643 KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD---ELEKMKQLHRCP 1699
               LK +++        LVS    +LS+V+ +  + +++N  L++   ELE+  Q+ +  
Sbjct: 2524 ISRLKNQIQ----DQEQLVS----KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575

Query: 1700 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1759
            + S  Q  +  + S  + L  E E    +  S V+K+ K +  E     +++E      +
Sbjct: 2576 NAS-LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE---TELQREMHEMAQK 2631

Query: 1760 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1819
            +A L+ +L  S EK   L   +Q +  ++   K  L+    E   LK+ +  +HK     
Sbjct: 2632 TAELQEEL--SGEK-NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688

Query: 1820 GGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1879
             GK    EIA +   LH  +K+             Q LL   N++ +  +Q  + +LT  
Sbjct: 2689 EGKV-REEIAEYQLRLHEAEKK------------HQALLLDTNKQYEVEIQTYREKLTSK 2735

Query: 1880 RE--KVRQLESNLLPKHQKHLNPS-----GTMNPTEQEKLSLKRECDQFQKEQSPANRK- 1931
             E    ++LE +LL   ++ LN S       +   ++ K+   +  +Q +KE   A  K 
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795

Query: 1932 ---VSQMNSLEQELETIHLENEGLKKKQ----------VKLDEQLMEMQHLRST 1972
               +     LE+E E +  E   L+  Q           K+DE   E++ L+ T
Sbjct: 2796 KLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849



 Score =  154 bits (389), Expect = 9e-37
 Identities = 392/1938 (20%), Positives = 777/1938 (40%), Gaps = 273/1938 (14%)

Query: 317  LDTWQEEGIENSQEILKALDFSLDGNINLT----ELTLALENELLVTKNSIHQAA----- 367
            L+  +E   +  QE L  L F+ + N NL      +  AL +E+   +N+    A     
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130

Query: 368  -LASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIE-RRNEYNL 425
             + + K E   + + V+ +++E E+L   +    + ++L +  + +     E  RN+ N 
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190

Query: 426  R-KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS-L 483
            + ++D E KE      N    + E +L+    +  E E+E E  + E   IR  L  S L
Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250

Query: 484  KENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMR 543
            ++    E   L++ E  AE + ++             +       +A      +      
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGP----------HELSTSQNDNAHLQCSLQTTMNKL 1300

Query: 544  NEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEE 603
            NE E+ C +LQ +  EL +EL + R++     +      +EEV    G +  E  + +++
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSEC----ITATRKMAEEV----GKLLNEVKILNDD 1352

Query: 604  CNPLNMSIEAEL----VIEQMKEQHHRDICCL-------RLELEDK-VRHYEKQLDETVV 651
               L+  +  ++      EQ  EQH   +  L        L L DK V+ +  +L E  +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412

Query: 652  SCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ 711
            S +   + +  +H      +  ++S+L+  +  L+ +  VL            +  K++Q
Sbjct: 1413 SLQSEHKILHDQHCQ----MSSKMSELQTYVDSLKAENLVLSTNLRNF---QGDLVKEMQ 1465

Query: 712  VKLEE---------------------EKTHLQEKLRLQHEMELKARLTQAQASFEREREG 750
            + LEE                     + +  +  L    +M L + L  A ++ +   + 
Sbjct: 1466 LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1525

Query: 751  LQSSAWTEEKV-RGLTQELEQFHQEQLTSLVE--KHTLEKEELRKE----LLEKHQRELQ 803
            +  S+  EE + R  T        E+L SL E  + +LEK E + E    +  K  +EL+
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585

Query: 804  E--GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE-E 860
            +    E+ E +C R+      Q+ S+ ++  ++  S    +E +   E K  ++   E E
Sbjct: 1586 QLLSSERQELDCLRK------QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELE 1639

Query: 861  KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQ 920
             ++ + +  +L+       +       R ++  +      E  E+T K  ++ +  +  Q
Sbjct: 1640 VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQ 1699

Query: 921  LLQDLE-DLRNVSETQQSLLSDQILELKSSHKR-------ELREREEVLCQAGASEQLAS 972
              QDL  D+  ++ET     + +    +S           + +   E + +   S   A 
Sbjct: 1700 --QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757

Query: 973  QRLERLEMEHDQERQEMMSKLLAMENIHKA-TCETADRERAEMSTEISRLQSKI--KEMQ 1029
              ++ L  + D    ++  K  + EN+      E  DR+   +  E+  L SK+  +E+Q
Sbjct: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQ 1817

Query: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQ----QGEQLLEE-------NGDVLLSLQR 1078
              T   + ++   +++GE + E       L+      ++LL+        N D+ +   +
Sbjct: 1818 LMTKIEACIELE-KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876

Query: 1079 AHEQAVKENVK------------MATEISRLQQRLQKLE-PGLVMSSCLDEPATEFFGNT 1125
            +  + + +NV             +  E+SR++     +E   L + + L+   TE     
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-- 1934

Query: 1126 AEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEG 1185
                    + N  KQ   V     LS +  +  +  G   T S +   +  + SE   E 
Sbjct: 1935 ------LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEK 1987

Query: 1186 FSELENSEETRTESWELKN-QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
              ELE+ +       ++   ++ +  E L  L +D         +LL D + L++KL+ L
Sbjct: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS-------ELLKDKTHLQEKLQSL 2040

Query: 1245 ERIPEASPKYKLLYED----VSRENDCLQEELRMMETRYDEA----LENNKELTAEVFRL 1296
            E+  +A    K   E+    +++E + L +E   ++ R  E+    L  +K L A +   
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100

Query: 1297 QDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEA 1356
             +   ++    E    L +  +++++  E      L +  K+++ +       D      
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD------ 2154

Query: 1357 SLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA 1416
             +ENLE E     LQ+++  +E V          E  K E + L+  TQ+ E  ++ ++ 
Sbjct: 2155 KVENLERE-----LQMSEENQELVILDA------ENSKAEVETLK--TQIEEMARSLKVF 2201

Query: 1417 WLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF---------QHQATIAELELEKTKL 1467
             L   +    E+  +  Q+  +E    L   DK           + QA I   E  KT +
Sbjct: 2202 ELD-LVTLRSEKENLTKQI--QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258

Query: 1468 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527
            + L  +LKE        + V +    +E +KA    L     E  Q    +     +L+ 
Sbjct: 2259 EMLQNQLKEL------NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312

Query: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
            +       +  L E +  ++L  G +   + E+  +     QE+AA++   EN K ++  
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLEREL--EIARTNQEHAALE--AENSKGEVET 2368

Query: 1588 LKIKNQ---------QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEE 1638
            LK K +         +LD+      ++N  N+  LQ+  +R++E+  +       + L+E
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNE--LQKEQERISEL--EIINSSFENILQE 2424

Query: 1639 REQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRC 1698
            +EQEK  +KE+       SST +  L+ +L E+  +   +  +    K + + +     C
Sbjct: 2425 KEQEKVQMKEK-------SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC 2477

Query: 1699 PDLSD----------------FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL 1742
             +L                   Q  ++ ++   E   ++ E   EE++   +++     L
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537

Query: 1743 EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ-------NLEDTVQNVNLQMSRMKSDL 1795
              +++ ++ E + W+ Q+  L++  V  ++K+Q       +L+DT++ +      ++++L
Sbjct: 2538 VSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597

Query: 1796 RVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD---KLDHL 1850
             +T+ +K +  ++V  M+  +          A + A     L  ++ RL+ +    L+ +
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657

Query: 1851 MNEEQQL--LWQENERLQTMVQNTKAELTHSREKVRQ--LESNLL-----PKHQKHLNPS 1901
             + + QL  L  EN  L+  +     +      KVR+   E  L       KHQ  L  +
Sbjct: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717

Query: 1902 GTMNPTE----QEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQV 1957
                  E    +EKL+ K EC   QK       ++  + S ++EL      N  LK    
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQK------LEIDLLKSSKEEL------NNSLKATTQ 2765

Query: 1958 KLDE-QLMEMQHLR-STATPSPSPHAWDLQLLQQQACPMVPRE-QFLQLQRQLLQAERIN 2014
             L+E +  +M +L+        +  A     L  ++C  +  E + LQ +   LQA +  
Sbjct: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825

Query: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLL--QEKVNQLKEQVS 2072
            Q     ++ +  E  T     ++L   +EE+  E ++ L     LL   EK+ + KE + 
Sbjct: 2826 QKTGTVMDTKVDELTT---EIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882

Query: 2073 LP-GHLCSPTSHSSFNSS 2089
                HLCS  S      S
Sbjct: 2883 TQVAHLCSQQSKQDSRGS 2900



 Score =  139 bits (350), Expect = 3e-32
 Identities = 248/1139 (21%), Positives = 484/1139 (42%), Gaps = 196/1139 (17%)

Query: 284  RRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNI 343
            +R  TS  + S +         + +G  +V ++ D+W+E  ++   E+ +    S   +I
Sbjct: 1858 QRVETSEGLNSDLEMHADKSSREDIGD-NVAKVNDSWKERFLDVENELSRIR--SEKASI 1914

Query: 344  NLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLK 403
                L L  + E++ T+    +    + +  I  L E +  V  E+ +LR +LD   K  
Sbjct: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974

Query: 404  SLM---ASEVDDHHAAIERRNE---YNLRKLDEEYKERIAALK------NELRKEREQI- 450
            + +   + ++ +    +E       + ++  + E KE+   L+      +EL K++  + 
Sbjct: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034

Query: 451  --LQQAGKQ-------RLELEQEIEKAKTEENYI-------RDRLALS----LKENSRLE 490
              LQ   K        + ELE +I +   E+  +       + RL+ S    L  +  LE
Sbjct: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094

Query: 491  NELLENAE---KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 547
              L+E  E   +L+  +   ++L+R +E +      D          ++  + +   E E
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK--------KQLHIAEKLKERE 2146

Query: 548  RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
            R+   L+D+V+ L+ EL+       ++ L  +NS +E     +   E    L   E + +
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENE 667
             +  E E + +Q++E+  +       EL+  +  ++  L+E     ++A+  +K+  +  
Sbjct: 2207 TLRSEKENLTKQIQEKQGQ-----LSELDKLLSSFKSLLEEK----EQAEIQIKEESKTA 2257

Query: 668  THTLEKQISDLKNEIAELQGQAAVLK----------EAHHEATCRHE--------EEKKQ 709
               L+ Q+ +L   +A L G   ++K          E  H+     E        +EKKQ
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317

Query: 710  LQV--KLEEEKTH---LQEKL-RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRG 763
            L V  +L+E + H   L+ ++  L+ E+E+ AR  Q  A+ E E    +     + K+ G
Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEI-ARTNQEHAALEAENSKGEVET-LKAKIEG 2375

Query: 764  LTQELEQFHQEQLTSLVEK----HTLEKEELR---KELLEKHQRELQEGREKMETECNRR 816
            +TQ L     + +T   EK    + L+KE+ R    E++      + + +E+ + +   +
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435

Query: 817  TSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQEC 875
            +S      Q+  +++ ER  +AL +      QE    +EQ    + +  E EK +L Q  
Sbjct: 2436 SSTAMEMLQTQLKELNERV-AALHN-----DQEACKAKEQNLSSQVECLELEKAQLLQGL 2489

Query: 876  AEAQELLKETLKREKTTSLVLTQE--REMLEKTYKE--HLNSMVVERQQLLQDLEDLRNV 931
             EA+      + +     L+   E  ++ LEK  +E   L + + +++QL+  L  +   
Sbjct: 2490 DEAKN--NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV--- 2544

Query: 932  SETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEM-- 989
             E +  L  +Q LEL++    EL ++ +VL    AS Q     LE L+  +     E+  
Sbjct: 2545 -EGEHQLWKEQNLELRNL-TVELEQKIQVLQSKNASLQ---DTLEVLQSSYKNLENELEL 2599

Query: 990  --MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSG--CQVI 1045
              M K+  +E ++K T +  +            LQ ++ EM Q T+ L    SG   ++ 
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETE------------LQREMHEMAQKTAELQEELSGEKNRLA 2647

Query: 1046 GEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1105
            GE ++  +   S   Q ++L  EN ++  SL   H+  V++  K+  EI+  Q RL + E
Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAE 2707

Query: 1106 PGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG 1165
                                 +     L  N+  +VE  T R  L+  E+          
Sbjct: 2708 --------------------KKHQALLLDTNKQYEVEIQTYREKLTSKEE---------- 2737

Query: 1166 TSSVQRQEVKI-----EESEASVEGFSE-LENSEETRTESWELKNQI----SQLQEQLMM 1215
              S Q+ E+ +     EE   S++  ++ LE  ++T+ ++ +  NQ+     + Q ++ +
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKL 2797

Query: 1216 LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1275
            L   C +  E+K+       +L+K+L  L+   E                   Q+   +M
Sbjct: 2798 LIKSCKQLEEEKE-------ILQKELSQLQAAQEK------------------QKTGTVM 2832

Query: 1276 ETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
            +T+ DE     KEL      L+++ K+ +E  + + SL  S+++++   E L   V  L
Sbjct: 2833 DTKVDELTTEIKELKE---TLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888



 Score =  139 bits (349), Expect = 4e-32
 Identities = 397/1980 (20%), Positives = 776/1980 (39%), Gaps = 343/1980 (17%)

Query: 262  SASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQ 321
            S+++    ++R  S   F  SG +  T S  T  IG R          ++S   +LD   
Sbjct: 229  SSNSQRTPIRRDFSASYF--SGEQEVTPSRSTLQIGKR--DANSSFFDNSSSPHLLDQ-- 282

Query: 322  EEGIENSQEILKALDFSLDGNINLTELTL-ALENELLVTKNSIHQAALASFKAEIRHLLE 380
                      LKA +  L   IN  EL L   E E+    N   +  L   KA++  L+E
Sbjct: 283  ----------LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVE-LIE 331

Query: 381  RV-------DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR-KLDEEY 432
            +        D++VR   +      K   L+  +    +D   + +R+N  + R  L+++ 
Sbjct: 332  KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTED--LSCQRQNAESARCSLEQKI 389

Query: 433  KERIAALKNELRKER---EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRL 489
            KE+    + EL +++   + + Q+  + +  L QE+++AK   N ++  L        +L
Sbjct: 390  KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449

Query: 490  ENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 549
            EN L E  +KL   E      Q                      ++E  L +   E +++
Sbjct: 450  ENNLEEFKQKLCRAEQAFQASQ----------------------IKENELRRSMEEMKKE 487

Query: 550  CRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNM 609
              +L+   ++   E+    A+ + ++  L  S +                 +EE    N 
Sbjct: 488  NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN----------------FAEEMKAKNT 531

Query: 610  SIEAELVIEQMKEQHHRDICCLRLE-LEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 668
            S   E ++  ++E+ ++    L LE L+  V   EKQ D +    KK + +++Q ++  +
Sbjct: 532  S--QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589

Query: 669  HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 728
             T EK+   L + +   + +   LKE     +C   E +K L  ++E EK +LQ K+   
Sbjct: 590  KT-EKESKALLSALELKKKEYEELKEEKTLFSCWKSENEK-LLTQMESEKENLQSKIN-H 646

Query: 729  HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 788
             E  LK +  ++    ER R         E     L+ E+   H    +  VE  T +  
Sbjct: 647  LETCLKTQQIKSHEYNERVRT-------LEMDRENLSVEIRNLHNVLDSKSVEVETQKLA 699

Query: 789  ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 848
             +  EL +K +   Q+ ++++E  C  +TSQ+  Q         E  E  LQ L      
Sbjct: 700  YM--ELQQKAEFSDQKHQKEIENMC-LKTSQLTGQ--------VEDLEHKLQLLS----N 744

Query: 849  ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 908
            E+ D     ++  +++E  +D L  +  +A  +  E  +R    SL+   ++  +  ++ 
Sbjct: 745  EIMDKDRCYQDLHAEYESLRDLLKSK--DASLVTNEDHQR----SLLAFDQQPAMHHSFA 798

Query: 909  EHL---NSMVVERQQ-------------LLQDLEDLRNVS-ETQQSLLSD------QILE 945
              +    SM  ER +             +LQ+  D    S E+Q+ + SD      ++++
Sbjct: 799  NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858

Query: 946  LKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA--- 1002
            +K   +  L + E+ + Q+  +E   SQR+ +L+ +    +  +   L A+EN  K    
Sbjct: 859  IKGEIEENLMKAEQ-MHQSFVAE--TSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915

Query: 1003 ---TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSL- 1058
                 ET   E  E+      L+  +KE+Q  +  LS+          E+ E    +SL 
Sbjct: 916  LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL----------EKKEMSSIISLN 965

Query: 1059 LQQGEQLLEENG---DVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLD 1115
             ++ E+L +ENG   ++  SL +     ++++   A  I   ++ + +L         + 
Sbjct: 966  KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025

Query: 1116 EPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVK 1175
                E  GN                 E +++++  +  ++ ++  L +  TS  + ++ +
Sbjct: 1026 LQRCEETGNA---------------YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNE 1070

Query: 1176 IEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
            +E+ +   E F++      T+    E +NQ   L+ + +      +  ++ + +   +  
Sbjct: 1071 LEQLK---EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE-MTDNQNNSKSEAG 1126

Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYD------EALENN-KE 1288
             LK+++  L+   E   K +    D+ +EN+ L   +++M+T+++      E + N+ KE
Sbjct: 1127 GLKQEIMTLK---EEQNKMQKEVNDLLQENEQL---MKVMKTKHECQNLESEPIRNSVKE 1180

Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQR 1348
              +E  R Q   K   ++    +SL+ SY      N +L  L   L+ K  KLQES  ++
Sbjct: 1181 RESE--RNQCNFKPQMDLEVKEISLD-SY------NAQLVQLEAMLRNKELKLQESEKEK 1231

Query: 1349 CDCCLWEASLENLEIEPDGNILQLNQT-----LEECVPRVRSVHHVIEECKQENQYLEGN 1403
             +C   E  L+ +  + + + LQ  Q+     L++C            E   E +Y+ G 
Sbjct: 1232 -ECLQHE--LQTIRGDLETSNLQDMQSQEISGLKDC------------EIDAEEKYISGP 1276

Query: 1404 TQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELE 1463
             +L      ++ A L  ++QT   +        LE+   +L       +    + EL   
Sbjct: 1277 HEL--STSQNDNAHLQCSLQTTMNKLNE-----LEKICEIL-----QAEKYELVTELNDS 1324

Query: 1464 KTKLQELTRKLKERVTILVKQKDVLS------HGEKEEELKA--------MMHDLQITCS 1509
            +++    TRK+ E V  L+ +  +L+      HGE  E++            H + +   
Sbjct: 1325 RSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL 1384

Query: 1510 EMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ 1569
            +     E L    +++Q   + L+ +  +L  E  I + +   ++    E+    +++K 
Sbjct: 1385 DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKA 1444

Query: 1570 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS---------------------- 1607
            EN  +   + N +  +    +K  QL LE   +   +S                      
Sbjct: 1445 ENLVLSTNLRNFQGDL----VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALL 1500

Query: 1608 ---------QNQEKLQELNQ-RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQS 1657
                      N E     NQ  + E+ C   +E   +  E        ++E    C+V  
Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYR 1560

Query: 1658 STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHR--CPDLSDFQQKISSV-LSY 1714
             +L    E   S+  ++   +Q+   LL  E +++  L +    +   +QQK++SV L  
Sbjct: 1561 QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM 1620

Query: 1715 NEKLLKEK---EALSEELNSCVDKLAKSSLLEHRIATMKQEQK----------SWEHQSA 1761
              KL  EK   E LS EL     +L    L    +  +  E            S EH S 
Sbjct: 1621 ESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE 1680

Query: 1762 SLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVT---------------QQEKEALK 1806
            + +        ++ + +D  Q++NL + ++     V                +   E   
Sbjct: 1681 TTERTPKHDVHQICD-KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739

Query: 1807 QEVMSLHKQLQNAGGKSWAP-EIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERL 1865
            Q       +L  +G  +  P +   +   +HN Q R+         NE  +LL    +R 
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK-----ETSNENLRLLHVIEDR- 1793

Query: 1866 QTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQ 1925
               V++   E+     K+   E  L+ K +  +     +   ++E   L  + + F  + 
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853

Query: 1926 SPANRKVSQMNSLEQELE-------------TIHLENEGLKKKQVKLDEQLMEMQHLRST 1972
                ++V     L  +LE              +   N+  K++ + ++ +L  ++  +++
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913

Query: 1973 ATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQ 2032
                      DL+++Q +          L L++     +++   L+EEL   TSE N  +
Sbjct: 1914 IEHEALYLEADLEVVQTEK---------LCLEKDNENKQKVIVCLEEELSVVTSERNQLR 1964

Query: 2033 GN----------QEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTS 2082
            G            +QL   M+E+  E+E         +Q    ++KE+  L   L S  S
Sbjct: 1965 GELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024



 Score =  132 bits (331), Expect = 5e-30
 Identities = 348/1759 (19%), Positives = 673/1759 (38%), Gaps = 303/1759 (17%)

Query: 443  LRKEREQILQQAGKQRLELEQEIEKAKTEEN---YIRDRLALSL-KENSRLENELLENAE 498
            L + +E +  +A ++  ELE +++K K E+    +  D L  +L K+  ++ENE  E   
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63

Query: 499  KLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 558
                  NL  + QR +E                     E L + + +   + +V + QV+
Sbjct: 64   ------NLKRENQRLMEIC-------------------ESLEKTKQKISHELQVKESQVN 98

Query: 559  ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 618
              + +L   + Q   L   LK   SE   +       +  L     NP N   +      
Sbjct: 99   FQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSL-----NPCNTPQKI----- 148

Query: 619  QMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDL 678
                                   +   L  +        E++K+++  E    ++  +++
Sbjct: 149  -----------------------FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185

Query: 679  KNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLT 738
            K   A+   Q       +H    RH+        + E+  +HL       +      R  
Sbjct: 186  KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-----SNSQRTPIRRD 240

Query: 739  QAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH 798
             + + F  E+E   S +  +   R        F       L+++   + +ELR ++ E  
Sbjct: 241  FSASYFSGEQEVTPSRSTLQIGKRDANSSF--FDNSSSPHLLDQLKAQNQELRNKINELE 298

Query: 799  QRELQEGREKMETECNRRTSQIEAQFQS------DCQKVTERCESALQSLEGRY------ 846
             R LQ   ++M+ + N +  +++ Q +       + +KV  +C   L     +Y      
Sbjct: 299  LR-LQGHEKEMKGQVN-KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTK 356

Query: 847  ----RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREM 902
                 Q+LK L E    ++   E  +  L Q+  E ++  +E L R++ +   L QE   
Sbjct: 357  YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE--- 413

Query: 903  LEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLC 962
                        +  + +L Q+L+  +N+    Q+ L D++  +K   +  L E ++ LC
Sbjct: 414  -----------CIQMKARLTQELQQAKNMHNVLQAEL-DKLTSVKQQLENNLEEFKQKLC 461

Query: 963  ---QAGASEQLASQRLER-----------LEMEHDQERQEMMSKLLAMENIHKAT----- 1003
               QA  + Q+    L R           L+   +Q+ +E+      ++NI +       
Sbjct: 462  RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521

Query: 1004 -CETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQG 1062
              E    +     T +  LQ KI + + + +    L+     + + E + D +  LL++ 
Sbjct: 522  FAEEMKAKNTSQETMLRDLQEKINQQENSLT----LEKLKLAVADLEKQRDCSQDLLKKR 577

Query: 1063 EQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFF 1122
            E  +E+  D L        +  KE+  + + +   ++  ++L+    + SC      +  
Sbjct: 578  EHHIEQLNDKL-------SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630

Query: 1123 GNTAEQTEPFLQQ-------NRTKQVEGVTRRHVLSDLEDD------EVRDLGSTGTS-- 1167
                 + E    +        +T+Q++       +  LE D      E+R+L +   S  
Sbjct: 631  TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690

Query: 1168 -SVQRQEVKIEESEASVEGFSELENSEETRT---ESWELKNQISQLQEQLMMLCADCDRA 1223
              V+ Q++   E +   E FS+ ++ +E      ++ +L  Q+  L+ +L +L  +    
Sbjct: 691  VEVETQKLAYMELQQKAE-FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDK 749

Query: 1224 SEKKQDLLFDVSVLKKKLKMLER-------------IPEASPKYKLLYEDVSRENDCLQE 1270
                QDL  +   L+  LK  +                +  P     + ++  E   +  
Sbjct: 750  DRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPS 809

Query: 1271 ELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT-------ETFLSLEKSYDEVKIE 1323
            E        D++ +N+  L   V  L+  L+  +++        E  + ++   +E  ++
Sbjct: 810  ERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMK 869

Query: 1324 NEELN-VLVLRLQGKIEKLQESVVQRCDCCLWEAS-LENLEIEPDGNILQL----NQTLE 1377
             E+++   V     +I KLQE      +      S LEN E E     LQL     +T +
Sbjct: 870  AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE-----LQLLNDKVETEQ 924

Query: 1378 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVIL 1437
              +  ++  +H++E+  +E Q L   T  LEK +   I  L+   +   E    +N  + 
Sbjct: 925  AEIQELKKSNHLLEDSLKELQLL-SETLSLEKKEMSSIISLN---KREIEELTQENGTLK 980

Query: 1438 EENTTLLGFQDKHFQHQATIAELELEKTK-LQELTRKLKERVTILVKQKDVLSHG----- 1491
            E N +L   +    Q   + A    E+ K + EL+ + K+   IL+++ +   +      
Sbjct: 981  EINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLS 1040

Query: 1492 -------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDS 1544
                   EK  +L+ ++++    C   + ++E L+   E   +E+     ++    E + 
Sbjct: 1041 QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK---EAFAKEHQEFLTKLAFAEERNQ 1097

Query: 1545 ISNLKLGTLNGS-QEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELS 1603
               L+L T+  + + EM       K E          LK++I  LK +  ++  E  +L 
Sbjct: 1098 NLMLELETVQQALRSEMTDNQNNSKSE-------AGGLKQEIMTLKEEQNKMQKEVNDLL 1150

Query: 1604 QKNSQNQEKLQELNQRLTEMLCQK-EKEPGNSALEEREQEK--FNLKEELERCKVQSSTL 1660
            Q+N Q  + ++      T+  CQ  E EP  ++++ERE E+   N K +++  +V+  +L
Sbjct: 1151 QENEQLMKVMK------TKHECQNLESEPIRNSVKERESERNQCNFKPQMD-LEVKEISL 1203

Query: 1661 VS------SLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQ-QKISSV-- 1711
             S       LEA L   +++    ++E   L+ EL+ ++      +L D Q Q+IS +  
Sbjct: 1204 DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD 1263

Query: 1712 --LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1769
              +   EK +     LS   N   D       L+  +  + + +K  E   A        
Sbjct: 1264 CEIDAEEKYISGPHELSTSQN---DNAHLQCSLQTTMNKLNELEKICEILQAE------- 1313

Query: 1770 SQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQN--AGGKSWAPE 1827
              E V  L D+         +M  ++     E + L  +   LH +L     GG     E
Sbjct: 1314 KYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGG-----E 1368

Query: 1828 IATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLE 1887
                P    N+Q  +S   LD   N  + L   + E     VQ   AEL   +EK   L+
Sbjct: 1369 FGEQP----NEQHPVSLAPLDE-SNSYEHLTLSDKE-----VQMHFAEL---QEKFLSLQ 1415

Query: 1888 SNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHL 1947
            S     H +H   S  M+  +    SLK E                   +L       + 
Sbjct: 1416 SEHKILHDQHCQMSSKMSELQTYVDSLKAE-------------------NLVLSTNLRNF 1456

Query: 1948 ENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQF--LQLQR 2005
            + + +K+ Q+ L+E L  +  L S+  P  S     L  L   +      EQ   + L  
Sbjct: 1457 QGDLVKEMQLGLEEGL--VPSLSSSCVPDSS----SLSSLGDSSFYRALLEQTGDMSLLS 1510

Query: 2006 QLLQAERINQ---------HLQEELENRTSETNTPQGNQEQLVTVME---ERMIEVEQKL 2053
             L  A   NQ          LQEE   R    + P    E+L ++ E   + + ++E+K+
Sbjct: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570

Query: 2054 KLVKRLLQEKVNQLKEQVS 2072
            +    +  +++ +L++ +S
Sbjct: 1571 ESQGIMKNKEIQELEQLLS 1589



 Score =  127 bits (319), Expect = 1e-28
 Identities = 379/1818 (20%), Positives = 734/1818 (40%), Gaps = 256/1818 (14%)

Query: 317  LDTWQEEGIENSQEILKALDFSLDG--------NINLTELTLALENELLVTKNSIHQAAL 368
            L+ W+E     + + ++ L+  LD            L  L  AL+ +    +N   +   
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT- 63

Query: 369  ASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKL 428
             + K E + L+E  + + + K+K+  +L   E   +    +++     IE+  +   R  
Sbjct: 64   -NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122

Query: 429  DEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 488
             E  + + AA   ++        Q+     L   Q    +K E+  ++++    ++E  R
Sbjct: 123  SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED--LKEKYNKEVEERKR 180

Query: 489  LENELLE-NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 547
            LE E+    A+K ++         R++    A        SS+ F  Q+E+     +   
Sbjct: 181  LEAEVKALQAKKASQTLPQATMNHRDIARHQA--------SSSVFSWQQEKTPSHLSSNS 232

Query: 548  RQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
            ++  + +D      S  +E       L++  +++ S   + NS        L ++     
Sbjct: 233  QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFD-NSSSPHLLDQLKAQNQELR 291

Query: 608  NMSIEAELVIE----QMKEQHHRDICCLRLELED-KVRHYEKQLDETVVSCKKAQENMKQ 662
            N   E EL ++    +MK Q ++    L+L+LE  KV   EK  ++ +  C+        
Sbjct: 292  NKINELELRLQGHEKEMKGQVNK-FQELQLQLEKAKVELIEK--EKVLNKCRDELVRTTA 348

Query: 663  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
            +++  +     + + L+ ++ +L    +  ++    A C  E++ K+ + + +EE +  Q
Sbjct: 349  QYDQAS----TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404

Query: 723  EKLRL--QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
               +   Q  +++KARLTQ     +     LQ+     +K+  + Q+LE   +E      
Sbjct: 405  RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL---DKLTSVKQQLENNLEE------ 455

Query: 781  EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERC--ESA 838
             K  L + E   +  +  + EL+   E+M+ E N   S  E       QK  E C  E+ 
Sbjct: 456  FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE-------QKAREVCHLEAE 508

Query: 839  LQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQ 898
            L++++    Q     +E + +  SQ    +D   QE    QE    +L  EK    V   
Sbjct: 509  LKNIKQCLNQSQNFAEEMKAKNTSQETMLRD--LQEKINQQE---NSLTLEKLKLAVADL 563

Query: 899  EREMLEKTYKEHLNSMVVERQQLLQDLED-LRNVSETQQSLLSDQILELKSSHKRELRER 957
            E++      ++    ++ +R+  ++ L D L    +  ++LLS   LELK     EL+E 
Sbjct: 564  EKQ------RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS--ALELKKKEYEELKE- 614

Query: 958  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKA----------TCETA 1007
            E+ L     SE       E+L  + + E++ + SK+  +E   K              T 
Sbjct: 615  EKTLFSCWKSEN------EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668

Query: 1008 DRERAEMSTEISRLQSKI--KEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
            + +R  +S EI  L + +  K ++  T  L+ ++                   LQQ  + 
Sbjct: 669  EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME-------------------LQQKAEF 709

Query: 1066 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNT 1125
             ++           H+   KE   M  + S+L  +++ LE  L + S         + + 
Sbjct: 710  SDQK----------HQ---KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756

Query: 1126 AEQTEPFLQQNRTKQVEGVTRR-HVLSDLEDDE--------VRDLGSTGTSSVQRQEVKI 1176
              + E      ++K    VT   H  S L  D+           +G  G+   +R E ++
Sbjct: 757  HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL 816

Query: 1177 EESEASVEGFSELENSEETRTESWELKNQI-SQLQEQLMMLCADCDRASEKKQDLLFDVS 1235
             E++ S +  + L+N  ++   S E + Q+ S LQ+Q       C+   + K ++  + +
Sbjct: 817  -EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ-------CEELVQIKGEI--EEN 866

Query: 1236 VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR 1295
            ++K +      + E S +   L ED S   + + E L  +E +  E    N ++  E   
Sbjct: 867  LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926

Query: 1296 LQDELKKMEEVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIEKL--QESVVQRCDCC 1352
            +Q ELKK   + E  L  L+   + + +E +E++ ++   + +IE+L  +   ++  +  
Sbjct: 927  IQ-ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985

Query: 1353 LWEASLENLEIEPDGNILQLNQTLEECV-PRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1411
            L +  +         N++Q +++    +  R +S+  + ++ KQE   L    +  E   
Sbjct: 986  LNQEKM---------NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE--ETGN 1034

Query: 1412 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1471
            A+E   L    +  QE+   + + +L E T+L                 E  K +L++L 
Sbjct: 1035 AYED--LSQKYKAAQEK-NSKLECLLNECTSL----------------CENRKNELEQLK 1075

Query: 1472 RKL-KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESE-KLQQEN 1529
                KE    L K    L+  E+  +      +L +    +QQ +     +++   + E 
Sbjct: 1076 EAFAKEHQEFLTK----LAFAEERNQ------NLMLELETVQQALRSEMTDNQNNSKSEA 1125

Query: 1530 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQ----KTETVKQENAAVQKMVENLKKQI 1585
              L+ EI TL EE +    ++  L    E++ +    K E    E+  ++  V+  + + 
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185

Query: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN 1645
            ++   K  Q+DLE  E+S  +S N + +Q     L  ML  KE +     L+E E+EK  
Sbjct: 1186 NQCNFK-PQMDLEVKEIS-LDSYNAQLVQ-----LEAMLRNKELK-----LQESEKEKEC 1233

Query: 1646 LKEELE--RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL-KDELEKMK--QLHRCPD 1700
            L+ EL+  R  +++S L      E+S +K    I  +E ++    EL   +    H    
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGLK-DCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292

Query: 1701 LSDFQQKISSVLSYNEKLLKEKEALSEELN-SCVDKLAKSSLLEHRIATMKQEQKSWEHQ 1759
            L     K++ +    E L  EK  L  ELN S  + +  +  +   +  +  E K     
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352

Query: 1760 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1819
            S  L  +LV      +  E   +   + ++ +           E+   E ++L  +    
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL----------DESNSYEHLTLSDK---- 1398

Query: 1820 GGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1879
                   E+  H + L  Q+K LS      +++++   +  +   LQT V + KAE    
Sbjct: 1399 -------EVQMHFAEL--QEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449

Query: 1880 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLE 1939
               +R  + +L+ + Q  L         E    SL   C       S           LE
Sbjct: 1450 STNLRNFQGDLVKEMQLGLE--------EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLE 1501

Query: 1940 QELETIHLEN-EG-LKKKQVKLDE---QLMEMQHLRSTATPS-PSPHAWDLQLLQQQACP 1993
            Q  +   L N EG +   Q  +DE     ++ ++L    TPS P+    +L+ L +    
Sbjct: 1502 QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCE---- 1557

Query: 1994 MVPREQFLQLQRQL-LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQK 2052
             V R+   +L+ ++  Q    N+ +QE  +  +SE       ++Q ++  E    + +QK
Sbjct: 1558 -VYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE----QWQQK 1612

Query: 2053 LKLVKRLLQEKVNQLKEQ 2070
            L  V   ++ K+   K+Q
Sbjct: 1613 LTSVTLEMESKLAAEKKQ 1630



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 109/522 (20%), Positives = 222/522 (42%), Gaps = 68/522 (13%)

Query: 1573 AVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG 1632
            A+QK ++ L+ Q+ +LK + QQ   +   L     + ++K++  N++      ++E +  
Sbjct: 16   ALQK-IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE--NEKTEGTNLKRENQRL 72

Query: 1633 NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKM 1692
                E  E+ K  +  EL+  + Q    V+  E +L+  K Q   ++QE    K ELE+ 
Sbjct: 73   MEICESLEKTKQKISHELQVKESQ----VNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128

Query: 1693 KQLHRCPDLS----DFQQKI-SSVLSYNEKLLKEK-EALSEELNSCVDKLAKSSLLEHRI 1746
            +Q  +  D+S    +  QKI ++ L+ ++     K E L E+ N  V++  +   LE  +
Sbjct: 129  QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR---LEAEV 185

Query: 1747 ATMKQEQKSWEHQSASLKSQLVASQEKVQNL-----EDTVQNV--NLQMSRMKSDLRVTQ 1799
              ++ ++ S     A++  + +A  +   ++     E T  ++  N Q + ++ D   + 
Sbjct: 186  KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245

Query: 1800 QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLW 1859
               E   QEV      LQ  G +        + S  H          LD L  + Q+L  
Sbjct: 246  FSGE---QEVTPSRSTLQ-IGKRDANSSFFDNSSSPH---------LLDQLKAQNQELRN 292

Query: 1860 QENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECD 1919
            + NE L+  +Q  + E+     K ++L+  L     + +     +N    E +    + D
Sbjct: 293  KINE-LELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351

Query: 1920 QFQKEQSPANRKVSQ----MNSLEQELETIHLE-NEGLKKKQVKLDEQLMEMQHLRSTAT 1974
            Q   + +   +K+ +    ++   Q  E+      + +K+K+ +  E+L   Q       
Sbjct: 352  QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR------ 405

Query: 1975 PSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGN 2034
                      Q L Q+   M  R     L ++L QA+ ++  LQ EL+  TS     + N
Sbjct: 406  --------SFQTLDQECIQMKAR-----LTQELQQAKNMHNVLQAELDKLTSVKQQLENN 452

Query: 2035 QEQLVTVMEERMIEVEQKL---KLVKRLLQEKVNQLKEQVSL 2073
             E+     ++++   EQ     ++ +  L+  + ++K++ +L
Sbjct: 453  LEE----FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  160 bits (404), Expect = 2e-38
 Identities = 338/1582 (21%), Positives = 638/1582 (40%), Gaps = 254/1582 (16%)

Query: 347  ELTLALENELLVTKNS--------IHQAALASFKAEIRHLLERVDQVVREKE-----KLR 393
            EL LA   +LL  K++        I + AL + K     L  +  + +R+K      +L 
Sbjct: 234  ELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 394  SDLDKAEKLKSLMASEVDDHHAAIERRN---EYNLRKLDEEYKERIAALKNELRKEREQI 450
              L + + LK+   S++D     +   N    + LR+     ++   AL NEL +E  + 
Sbjct: 294  ETLKQCQDLKT-EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDAL-NELTEEHSKA 351

Query: 451  LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL 510
             Q+  +++ +LE+E+  A  ++  + ++            NE+L+   KL++ E   ++L
Sbjct: 352  TQEWLEKQAQLEKELSAALQDKKCLEEK------------NEILQG--KLSQLEEHLSQL 397

Query: 511  QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE------- 563
            Q N      E  GD+        L++E  T   N  + Q RV   + +  Q E       
Sbjct: 398  QDNPPQEKGEVLGDVLQLET---LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER 454

Query: 564  --LEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV-IEQM 620
               EE + Q   L   L++S S   +A     +     G+     +  S+ +EL  +   
Sbjct: 455  GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQV-ASLTSELTTLNAT 513

Query: 621  KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKN 680
             +Q  +++  L+ + ++K    + QL +T+   ++A + ++ + E  + +L+++   LK 
Sbjct: 514  IQQQDQELAGLKQQAKEK----QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK- 568

Query: 681  EIAELQGQAAVLKEAHHEATCRHEEEK---------KQLQVKLEEEKTHLQEKLRLQHEM 731
            E+AE Q +A     A   AT   E E          KQL+  LE+EK    E L+ Q ++
Sbjct: 569  EVAEKQ-EATRQDHAQQLATAAEEREASLRERDAALKQLEA-LEKEKAAKLEILQQQLQV 626

Query: 732  ELKAR------LTQAQ---ASFEREREGLQSSAWT----EEKVRGLTQELE-QFHQEQLT 777
              +AR      +TQAQ   A   R+ E LQ+   T    + + +    ELE Q   EQ  
Sbjct: 627  ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686

Query: 778  SLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCES 837
            +  ++   ++++  +E L+  +  L+  +  +E E  R    +E Q     Q+     ++
Sbjct: 687  ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ-----QRCISELKA 741

Query: 838  ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLT 897
              +SL  ++++E K+L+E++   K       +   Q+  EA +   E L+RE   ++   
Sbjct: 742  ETRSLVEQHKRERKELEEERAGRKGL-----EARLQQLGEAHQAETEVLRRELAEAMAA- 795

Query: 898  QEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSS---HKREL 954
                  + T +     +V E     +  ED +       ++  +Q++ LK      ++EL
Sbjct: 796  ------QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL 849

Query: 955  REREEVLC--QAGASEQLASQRLERLEMEHDQER--QEMMSKLLAMENIHKATCETADRE 1010
            +E +E +   ++ +  Q++ Q+ E  E+  +  R  Q++  K +  + +      T   +
Sbjct: 850  QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD-DLSTLQEK 908

Query: 1011 RAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENG 1070
             A  S E++RL++ +++  +     S      +++ E    GD      +Q E L E+ G
Sbjct: 909  MAATSKEVARLETLVRKAGEQQETASR-----ELVKEPARAGD------RQPEWLEEQQG 957

Query: 1071 DVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTE 1130
                S Q A +   +E  +M  E+ RL+  L + +              E  G    +  
Sbjct: 958  RQFCSTQAALQAMEREAEQMGNELERLRAALMESQG----------QQQEERGQQEREVA 1007

Query: 1131 PFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEV---KIEESEASVEGFS 1187
               Q+    Q +    +   ++LE      L          QE     + E E   +  +
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA 1067

Query: 1188 ELENSEETRT-ESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1246
            +L   E  +  E  EL+  + QL+EQL         A ++K+      S    + +   R
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQLKEQL---------AKKEKEH----ASGSGAQSEAAGR 1114

Query: 1247 IPEASPKYKLLYEDVSR-ENDCL--QEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1303
                 PK + L  +VS+ E  C   QE+   +E   +    +  E  + +  LQ +L++ 
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174

Query: 1304 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQ--GKIEKLQESVVQRCDCCLWEASLENL 1361
             +       L  S   +     EL     ++Q   K E   ++ V R      EA  +N 
Sbjct: 1175 AQ------ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR---QEAERKNS 1225

Query: 1362 EIEP-DGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAW--- 1417
             I   +  +  LN+ + E     + +  ++    +++Q LE   +LL+   A   A    
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285

Query: 1418 ----LHGTIQT---HQERPRVQNQVILEENTT-----------LLGFQDKHFQHQATIAE 1459
                L   +Q+     E+ RV ++ + +E T+           L  +Q+K FQ +  ++ 
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345

Query: 1460 LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1519
            L+LE T  Q L       V+ L+  K +    + E+      H                R
Sbjct: 1346 LQLEHTSTQAL-------VSELLPAKHLCQQLQAEQAAAEKRH----------------R 1382

Query: 1520 YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ---ENAAVQK 1576
             E E+ +Q    LR E+     E       LG L   ++++ ++  T +Q   E A+  +
Sbjct: 1383 EELEQSKQAAGGLRAELLRAQRE-------LGELIPLRQKVAEQERTAQQLRAEKASYAE 1435

Query: 1577 MVENLKKQISELKIKNQQL--------DLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1628
             +  LKK    L  +N+ L             EL Q   +  ++L  +       L + +
Sbjct: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ 1495

Query: 1629 KEPGNSALE------EREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQEN 1682
            +E  ++A E      + E  K  + EE +R + +   L + +E        Q  + Q+E 
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE--------QLEVFQREQ 1547

Query: 1683 HLLKDELEKMKQLHRCPDLSDFQQ-KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSL 1741
                +EL K  +L      S  QQ K+ +V +   +  +E + L  +LN           
Sbjct: 1548 TKQVEELSK--KLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ-------- 1597

Query: 1742 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE 1801
                 A + Q++++ EH    +        EK +   D  +  N ++      L   Q+E
Sbjct: 1598 -----AQLSQKEQAAEHYKLQM--------EKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644

Query: 1802 KEALKQEVMSLHKQLQNAGGKS 1823
             + L+ E   L  +LQ AG K+
Sbjct: 1645 NKELRAEAERLGHELQQAGLKT 1666



 Score =  157 bits (397), Expect = 1e-37
 Identities = 299/1456 (20%), Positives = 594/1456 (40%), Gaps = 220/1456 (15%)

Query: 770  QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE--KMETECNRRTSQIEAQFQSD 827
            QF   +L   +      ++EL  EL E  +   ++  +   M+   +R     E Q  S 
Sbjct: 213  QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASP 272

Query: 828  CQ-KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET- 885
             + K  E      +SL  R  + LK  Q+  + EKSQ + + ++L++E  +    L+E  
Sbjct: 273  LEPKELEELRDKNESLTMRLHETLKQCQDL-KTEKSQMDRKINQLSEENGDLSFKLREFA 331

Query: 886  --LKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD---LEDLRNVSETQQSLLS 940
              L++ +     LT+E     + + E    +  E    LQD   LE+   + + + S L 
Sbjct: 332  SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391

Query: 941  DQILELKSSHKRELRE-----------REEVLCQAGASEQLASQRLERLEMEHDQERQEM 989
            + + +L+ +  +E  E           ++E    A  + QL + R+E LE E  Q+    
Sbjct: 392  EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA-RVEMLETERGQQE--- 447

Query: 990  MSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQA---------------TSP 1034
             +KLLA E  H       + E+ ++S+ I+ LQS I  + QA               T+ 
Sbjct: 448  -AKLLA-ERGH------FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 1035 LSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHE--QAVKENVKMAT 1092
            ++ L S    +     + D  L+ L+Q  Q  E+   +  +LQ+  +  Q ++  V+  +
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQ--QAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557

Query: 1093 EISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRT--KQVEGVTRRHV- 1149
              S L+Q+ Q+L+          +   +     AE+ E  L++     KQ+E + +    
Sbjct: 558  --SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615

Query: 1150 -LSDLED-----DEVRDLGSTGTSSVQRQEV----KIEESEASVEGFSELENSEETRTES 1199
             L  L+      +E RD   T  +  QR++     K+EE +A VE           R E 
Sbjct: 616  KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE---------TARQEQ 666

Query: 1200 WELKNQISQLQEQL---MMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
             E + Q+++L+ QL        + +R +++K  L   +  LK+ LK+ +   E       
Sbjct: 667  HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE------- 719

Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
              E+  R  D L+E+ R +        E   E  + V + + E K++EE       LE  
Sbjct: 720  --EEKRRAADALEEQQRCIS-------ELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770

Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESVVQRCD-----CCLWEASLENLEIEPDGNILQ 1371
              ++   ++    ++ R   +    Q +    C+        W    E+ + E       
Sbjct: 771  LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830

Query: 1372 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI----QTHQE 1427
              + L             ++E K++   +E +++L    + +E+A LH  +    Q  QE
Sbjct: 831  FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890

Query: 1428 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQ--K 1485
            +  V+ Q + ++ +TL          Q  +A    E  +L+ L RK  E+     ++  K
Sbjct: 891  K-EVRAQKLADDLSTL----------QEKMAATSKEVARLETLVRKAGEQQETASRELVK 939

Query: 1486 DVLSHGEK-----EEELKAMMHDLQITCSEMQQKVELLRYESEKL-----------QQEN 1529
            +    G++     EE+        Q     M+++ E +  E E+L           Q+E 
Sbjct: 940  EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999

Query: 1530 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET-VKQENAAVQKMVENLKKQISEL 1588
                 E+  L +E   +   L     ++ E+  + +  + ++      + E L   ++E 
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK 1059

Query: 1589 KIKNQQL-DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKE----------------P 1631
            + K+Q+L  L   E +Q   +  E+L++  ++L E L +KEKE                P
Sbjct: 1060 EGKDQELAKLRGLEAAQ--IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117

Query: 1632 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEK 1691
                LE    E   L+++ ++ + Q+ +L  SLEAE +    +   ++     L+++ ++
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177

Query: 1692 MKQLHRCPDLSDFQQKISS----VLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIA 1747
            +   H    L+  Q+++++    V  +++   + K  ++        K +  S LE  ++
Sbjct: 1178 LG--HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235

Query: 1748 TMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQ 1807
             + ++    E +S  LK  ++A  EK Q LE+ ++   L  +   S+     +   AL++
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR---LLQAETASNSARAAERSSALRE 1292

Query: 1808 EVMSLHKQL----------------QNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLM 1851
            EV SL ++                 Q    +    E+         +++ LS  +L+H  
Sbjct: 1293 EVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTS 1352

Query: 1852 NEE--QQLLWQENERLQTMVQNTKAELTHSRE--KVRQLESNLLPKHQKHLNPSGTMNPT 1907
             +    +LL  ++   Q   +   AE  H  E  + +Q    L  +  +     G + P 
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPL 1412

Query: 1908 EQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK--------QVKL 1959
             Q+    +R   Q + E++       Q++ L++    +  EN GL ++        +V+L
Sbjct: 1413 RQKVAEQERTAQQLRAEKASY---AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469

Query: 1960 DEQ----LMEMQHLRSTATP-------SPSPHAWDLQLLQQQ----ACPMVPREQFLQLQ 2004
            D+     + E+  +R+ A              A +L+++  +       ++   Q  Q +
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529

Query: 2005 RQLLQAE--------RINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV 2056
            RQ L A+        R      EEL  + ++++     Q+Q +  ++ +  E +Q+    
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE---- 1585

Query: 2057 KRLLQEKVNQLKEQVS 2072
             + LQ ++N+L+ Q+S
Sbjct: 1586 AQRLQAQLNELQAQLS 1601



 Score =  149 bits (377), Expect = 2e-35
 Identities = 291/1470 (19%), Positives = 591/1470 (40%), Gaps = 174/1470 (11%)

Query: 368  LASFKAEIRHLLERVDQVVREKEKLRSD-LDKAEKLKSLMASEVDDHHAAIERRNEYNLR 426
            L  F + ++ L + ++++  E  K   + L+K  +L+  +++ + D    +E +NE    
Sbjct: 327  LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC-LEEKNEILQG 385

Query: 427  KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN 486
            KL +  +E ++ L++   +E+ ++L     Q   L+QE          ++ R+ +   E 
Sbjct: 386  KLSQ-LEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQLQARVEMLETER 443

Query: 487  SRLENELLENA----EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM 542
             + E +LL       E+  +  +L   LQ ++ N L++   +L+ +S        RLT  
Sbjct: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN-LSQAKEELEQASQA---HGARLTAQ 499

Query: 543  RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 602
                  +   L   + +   EL   + Q +  +  L  +  ++ +A+ G       L S 
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 603  ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYE---KQLD----ETVVSCKK 655
                     E     E  ++ H + +     E E  +R  +   KQL+    E     + 
Sbjct: 560  LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619

Query: 656  AQENMKQRHE------NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQ 709
             Q+ ++  +E            +++ ++L  ++ ELQ      ++  HEA  +  E + Q
Sbjct: 620  LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679

Query: 710  L---QVKLEEEKTHLQEKLRLQHEME-LKARLTQAQASFEREREGLQSSAWTEEKVRGLT 765
            L   Q K  E++   QEK +LQ +++ LK  L   + S E E+   +++   EE+ R ++
Sbjct: 680  LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR--RAADALEEQQRCIS 737

Query: 766  QELEQFHQEQLTSLVEKHTLEKEELRKEL-----LEKHQRELQEGREKMETECNRRTSQI 820
            +      + +  SLVE+H  E++EL +E      LE   ++L E  +  ETE  RR    
Sbjct: 738  EL-----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA-ETEVLRREL-- 789

Query: 821  EAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 880
             A+  +        CE  ++ +   +R+  +D Q+++ +  + ++ +   L +EC +A++
Sbjct: 790  -AEAMAAQHTAESECEQLVKEVAA-WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQ 847

Query: 881  LLKETLKR----EKTTSLVLTQEREMLEKTYK------EHLNSMVVERQQLLQDLEDLRN 930
             L+E  ++    E  + L +++++  L + +       + +    V  Q+L  DL  L+ 
Sbjct: 848  ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907

Query: 931  -VSETQQSLLSDQILELKSSHKRELREREEVLCQAGA-----------------SEQLAS 972
             ++ T + +   + L  K+  ++E   RE V   A A                 S Q A 
Sbjct: 908  KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967

Query: 973  QRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQAT 1032
            Q +ER   +   E + + + L+  +   +      +RE A ++ E  R Q+ +   + A 
Sbjct: 968  QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027

Query: 1033 SPLSM-LQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMA 1091
            + L M LQ+    + E+ VE       L       E     L  L+      +KE  ++ 
Sbjct: 1028 AELEMRLQNA---LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084

Query: 1092 TEISRLQQRLQKLEPGLVMSSCLDEPA---TEFFG---------------------NTAE 1127
              + +L+++L K E      S     A   TE  G                       A+
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144

Query: 1128 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1187
              E  L+  R  + E  +    L    +++ ++LG + ++    Q  ++      V+  S
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR-ELAAFRTKVQDHS 1203

Query: 1188 ELENSEET-----RTESWELKNQISQLQEQLMMLCADC-DRASEKKQDLLFDVSVLKKKL 1241
            + E+  +      R E+    + IS L+E++ +L     ++  E K+     ++  +K  
Sbjct: 1204 KAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263

Query: 1242 KMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE---ALEN-NKELTAEVFRLQ 1297
            K+ ER+     +        +  +  L+EE++ +    ++   A EN  +ELT++  R +
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323

Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
            +  ++++   E F   E++   +++E+     LV  L       Q+  +Q       +  
Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ--LQAEQAAAEKRH 1381

Query: 1358 LENLEIEPDG------NILQLNQTLEECVP---RVRSVHHVIEECKQENQYLEGNTQLLE 1408
             E LE            +L+  + L E +P   +V       ++ + E         +L+
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441

Query: 1409 KVKAHEIAWLHGTIQTHQ----ERPRVQNQVILEENTTLLGFQDKHFQHQATI------- 1457
            K         HG +        ER  +  Q +  E   L   ++K+ Q  A +       
Sbjct: 1442 KA--------HGLLAEENRGLGERANLGRQFLEVE---LDQAREKYVQELAAVRADAETR 1490

Query: 1458 -AELELEKT----KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQ 1512
             AE++ E      +L+ +T K +     +++++      E+ ++L A +  L++   E  
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ--EERQKLTAQVEQLEVFQREQT 1548

Query: 1513 QKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENA 1572
            ++VE L  +     Q + + + ++  +  +   S  +   L     E+  +    +Q   
Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE 1608

Query: 1573 AVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG 1632
              +  +E  K      K +NQ+L  +   L Q   +N+E L+   +RL            
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE-LRAEAERLG----------- 1656

Query: 1633 NSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV---QQENHLLKD-E 1688
                 E +Q     KE  + C+   +  V SLEA+++    Q   +   Q     LK  E
Sbjct: 1657 ----HELQQAGLKTKEAEQTCR-HLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711

Query: 1689 LEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1718
             +   QL    D  D   +  + LS   KL
Sbjct: 1712 PQAKPQLDLSIDSLDLSCEEGTPLSITSKL 1741



 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 201/982 (20%), Positives = 388/982 (39%), Gaps = 151/982 (15%)

Query: 1125 TAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR--------QEVKI 1176
            T +  +  + Q R  ++  +  +   S LE  E+ +L     S   R        Q++K 
Sbjct: 245  TEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKT 304

Query: 1177 EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV 1236
            E+S+   +     E + +   +  E  + + QLQ+ L  L  +  +A+++          
Sbjct: 305  EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEW--------- 355

Query: 1237 LKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFR- 1295
            L+K+ ++ + +  A    K L E    +N+ LQ +L  +E    +  +N  +   EV   
Sbjct: 356  LEKQAQLEKELSAALQDKKCLEE----KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGD 411

Query: 1296 -LQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLW 1354
             LQ E  K E  T                   L     +LQ ++E L+    Q+      
Sbjct: 412  VLQLETLKQEAAT-------------------LAANNTQLQARVEMLETERGQQ------ 446

Query: 1355 EASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE 1414
            EA L    +   G+  +  Q L   +  ++S    + + K+E          LE+     
Sbjct: 447  EAKL----LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEE----------LEQASQAH 492

Query: 1415 IAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKL 1474
             A L   + +        N  I +++  L G + +  + QA +A+   ++ +  +  R  
Sbjct: 493  GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552

Query: 1475 KERVTILVKQKDV-LSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES-----EKLQQE 1528
             E+++  +KQK+  L    +++E     H  Q+  +  +++  L   ++     E L++E
Sbjct: 553  VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612

Query: 1529 NS----ILRNEITTLNEEDSISNLKL-------GTLNGSQEEMWQKTETVKQENAAVQKM 1577
             +    IL+ ++   NE    +   +         L+   EE+    ET +QE    Q  
Sbjct: 613  KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672

Query: 1578 VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL--TEMLCQKEKEPGNSA 1635
            V  L+ Q+       QQ   E   ++Q+  Q QE+LQ L + L  T+   ++EK     A
Sbjct: 673  VAELELQLRS----EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728

Query: 1636 LEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1695
            LEE+++    LK E      Q       LE E +  K     +QQ     + E E +++ 
Sbjct: 729  LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR- 787

Query: 1696 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAK-SSLLEHRIATMKQEQK 1754
                +L++      +  S  E+L+KE  A  E       + A+  ++ + ++ T+K+E +
Sbjct: 788  ----ELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843

Query: 1755 SWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHK 1814
                     + +L  ++EKV  +E    +  LQ+SR +++L           Q+V     
Sbjct: 844  K-------ARQELQEAKEKVAGIES---HSELQISRQQNELAELHANLARALQQVQEKEV 893

Query: 1815 QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNT-K 1873
            + Q       A +++T                    + E+     +E  RL+T+V+   +
Sbjct: 894  RAQKL-----ADDLST--------------------LQEKMAATSKEVARLETLVRKAGE 928

Query: 1874 AELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVS 1933
             + T SRE V++               +G   P   E+   ++ C   Q       R+  
Sbjct: 929  QQETASRELVKEPAR------------AGDRQPEWLEEQQGRQFCST-QAALQAMEREAE 975

Query: 1934 QMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACP 1993
            QM +  + L    +E++G  ++Q +  +Q  E+  L      + +    DL L +     
Sbjct: 976  QMGNELERLRAALMESQG--QQQEERGQQEREVARLTQERGRAQA----DLALEKAARA- 1028

Query: 1994 MVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKL 2053
                E  ++LQ  L +       LQE L +  +E         +L  +   ++ E+E+  
Sbjct: 1029 ----ELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084

Query: 2054 KLVKRLLQEKVNQLKEQVSLPG 2075
            + VK+L ++   + KE  S  G
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSG 1106



 Score = 81.6 bits (200), Expect = 7e-15
 Identities = 168/824 (20%), Positives = 335/824 (40%), Gaps = 103/824 (12%)

Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV------HHVIEECKQE 1396
            E+V+Q  DC ++   ++ +    +G  + L Q + E +  V S       H    EC   
Sbjct: 25   EAVLQLQDCSIFIKIIDRIHGTEEGQQI-LKQPVSERLDFVCSFLQKNRKHPSSPECLVS 83

Query: 1397 NQ-YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE-ENTTLLGFQDKHFQHQ 1454
             Q  LEG+   LE  K   +   H T+ +   R   Q +  ++ E   +L F   H    
Sbjct: 84   AQKVLEGSE--LELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGL 141

Query: 1455 ATIAELE--LEKT------------KLQELTRKLKERVTILVKQKDVLSH-------GEK 1493
                +LE  L+K             +L   + + K  +  L  QK   S        G  
Sbjct: 142  NLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSP 201

Query: 1494 EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTL 1553
               +  ++   Q     +++++   R   ++L+ E +  R  +T  + + ++   ++  L
Sbjct: 202  ASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL 261

Query: 1554 NGSQEEMW------QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
                E+        ++ E ++ +N ++   +    KQ  +LK +  Q+D +  +LS++N 
Sbjct: 262  ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321

Query: 1608 QNQEKLQELNQRLTEM--LCQKEKEPGNSALEEREQEKFNLKEEL------ERCKVQSST 1659
                KL+E    L ++     +  E  + A +E  +++  L++EL      ++C  + + 
Sbjct: 322  DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381

Query: 1660 L----VSSLEAELSEVKIQTHIVQQENHLLKD--ELEKMKQLHRCPDLSDFQQKISSVLS 1713
            +    +S LE  LS+  +Q +  Q++  +L D  +LE +KQ       ++ Q +    + 
Sbjct: 382  ILQGKLSQLEEHLSQ--LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439

Query: 1714 YNEKLLKEKEALSEELNSCVDKLAKSSL---LEHRIATMKQ-----EQKSWEH------Q 1759
              E+  +E + L+E  +   +K   SSL   L+  I+ + Q     EQ S  H      Q
Sbjct: 440  ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 1760 SASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE---------------A 1804
             ASL S+L      +Q  +  +  +  Q    ++ L  T Q++E               +
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 1805 LKQEVMSLHK--QLQNAGGKSWAPEIAT----------HPSGLHNQQKRLSWDKLDHL-- 1850
            LKQ+   L +  + Q A  +  A ++AT                 Q + L  +K   L  
Sbjct: 560  LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619

Query: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
            + ++ Q+  +  +  QT V   + E      KV +L++ +    Q+       +   E +
Sbjct: 620  LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679

Query: 1911 KLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQV-KLDEQLMEMQHL 1969
              S +++  + ++     ++   Q+ +L++ L+      E  K++    L+EQ   +  L
Sbjct: 680  LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739

Query: 1970 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2029
            ++        H  + + L+++       E  LQ   +  QAE   + L+ EL    +  +
Sbjct: 740  KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE--TEVLRRELAEAMAAQH 797

Query: 2030 TPQGNQEQL---VTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
            T +   EQL   V    ER  + +Q+      + QE++  LKE+
Sbjct: 798  TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE 841


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  157 bits (397), Expect = 1e-37
 Identities = 241/1117 (21%), Positives = 485/1117 (43%), Gaps = 191/1117 (17%)

Query: 343  INLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLD-KAEK 401
            + + E  LA EN L  T+    Q+ L + K +++  L+   ++  E E+LR+ L  K ++
Sbjct: 855  VKVREKQLAAENRL--TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912

Query: 402  LKSLMASEVDDHHAAIERRNE--YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 459
            L+ +      D  A +E   E   +L+   ++ ++ I  L+ +L +E E   Q+   +++
Sbjct: 913  LEEIC----HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE-ESARQKLQLEKV 967

Query: 460  ELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 519
              E +++K + E+  + D+     KE   LE+ + E    L E E  +  L + L+N   
Sbjct: 968  TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-LKNKHE 1026

Query: 520  EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQ----GRVLR 575
                DL+        Q + L + R + E     L DQ+ ELQ+++ E + Q       L+
Sbjct: 1027 AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086

Query: 576  LPLKNSPSEEVEAN----------SGGIEPEHGLGSEECN-------------------- 605
              L     E  + N          S   E +  L SE  +                    
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146

Query: 606  PLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
             L  ++++    ++++ +  +++  L+  LE++ + +E Q+ E      +A E + ++ E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206

Query: 666  NETHT---LEKQISDLKNEIAELQGQAAVLKEAHHEATCRH---EEEKKQLQVKLEEE-- 717
                    LEK    L+NE  EL  +  VL +   ++  +    E + ++LQVK  E   
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266

Query: 718  -KTHLQEKL-RLQHEME-----------LKARLTQAQASFEREREGLQSSAWTEEKVR-G 763
             +T L +K+ +LQ E++             ++LT+  ++ E + +  Q     E + +  
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326

Query: 764  LTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKH----QRELQEGREKMETE--CNRRT 817
            L+ +L+Q   E+ +    +  LE+EE  K  LEK       ++ + ++KME    C    
Sbjct: 1327 LSTKLKQVEDEKNSF---REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 1383

Query: 818  SQIEAQFQSDCQKVTERCESA------LQSLEGRYRQELKDLQ---EQQRE-----EKSQ 863
             +++ + Q D + +++R E        L+  + R +QEL DL    + QR+     EK Q
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443

Query: 864  WEF-----EKDELTQECAEAQELLKETLKREKTTSLVLTQ----------EREMLEKTY- 907
             +F     E+  ++ + AE ++  +   + ++T +L L +          E E L K + 
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503

Query: 908  -----------------------KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL 944
                                   K  L   V E +  L++LED    +E  +  L   + 
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563

Query: 945  ELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH---- 1000
             +K+  +R+L+ R+E   Q+   ++   +++  +E E + ER++    + A + +     
Sbjct: 1564 AMKAQFERDLQGRDE---QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620

Query: 1001 --KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSL 1058
              +A  ++A++ R E   ++ +LQ+++K+  +        +   +++ + +       S+
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE--EILAQAKENEKKLKSM 1678

Query: 1059 LQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQ-------QRLQKLEPGLVMS 1111
              +  QL EE    L + +RA  QA +E  ++A EI+          +  ++LE  +   
Sbjct: 1679 EAEMIQLQEE----LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ- 1733

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ- 1170
              L+E   E  GNT       L  +R K+          ++L+ D++    +   S  Q 
Sbjct: 1734 --LEEELEEEQGNTE------LINDRLKK----------ANLQIDQINTDLNLERSHAQK 1775

Query: 1171 ----RQEVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLMMLCADCDRAS 1224
                RQ+++ +  E  V+   E+E + +++ ++    L+ +I+QL+EQL       D  +
Sbjct: 1776 NENARQQLERQNKELKVK-LQEMEGTVKSKYKASITALEAKIAQLEEQL-------DNET 1827

Query: 1225 EKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALE 1284
            +++Q     V   +KKLK +    +   +    Y+D   + D     L+ ++ + +EA E
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD---QADKASTRLKQLKRQLEEAEE 1884

Query: 1285 NNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVK 1321
              +   A   +LQ EL   E+ TET  ++ +    +K
Sbjct: 1885 EAQRANASRRKLQREL---EDATETADAMNREVSSLK 1918



 Score =  153 bits (386), Expect = 2e-36
 Identities = 241/1117 (21%), Positives = 472/1117 (42%), Gaps = 202/1117 (18%)

Query: 433  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
            +E + A + EL K RE+  Q A + RL   + ++     E        L L+E  + E E
Sbjct: 844  EEEMMAKEEELVKVREK--QLAAENRLTEMETLQSQLMAEK-------LQLQEQLQAETE 894

Query: 493  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
            L   AE+L     LT K Q      L E   DL+    E   +EER   ++ E ++    
Sbjct: 895  LCAEAEELRA--RLTAKKQE-----LEEICHDLEARVEE---EEERCQHLQAEKKK---- 940

Query: 553  LQDQVDELQSELEEYRAQGRVLRLP-------LKNSPSEEV--EANSGGIEPEHGLGSEE 603
            +Q  + EL+ +LEE  +  + L+L        LK    E++  E  +  +  E  L  + 
Sbjct: 941  MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000

Query: 604  CNPLNMSI----EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 659
                  ++    E    + ++K +H   I     +LE+++R  EKQ  E         E 
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMIT----DLEERLRREEKQRQEL--------EK 1048

Query: 660  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV------K 713
             +++ E ++  L  QI++L+ +IAEL+ Q A  +E    A  R EEE  Q  +      +
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108

Query: 714  LEEEKTHLQEKLRLQHEM-------------ELKARLTQAQASFEREREGLQSSAWTEEK 760
            LE + + LQE L  +                EL+A  T+ + + +      +  +  E++
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168

Query: 761  VRGLTQELEQ---FHQEQLTSLVEKHTLEKEELRKEL--LEKHQRELQEGREKMETECNR 815
            V  L + LE+    H+ Q+  + +KH+   EEL ++L   ++ +  L++ ++ +E E   
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228

Query: 816  RTSQIEA--QFQSDCQKVTERCESALQSLE------GRYRQELKD--------------L 853
              ++++   Q + D +   ++ E+ LQ L+       R R EL D              L
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288

Query: 854  QEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNS 913
              Q   + S+   +   L  +  + QELL+E  +++ + S  L Q  +  + +++E L  
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE-KNSFREQLEE 1347

Query: 914  MVVERQQLLQDLEDLRNVSETQQSLLSDQI--LELKSSHKRELREREEVLCQAGASEQLA 971
                +  L + +  L       +  + D +  LE     KR+L++  E L Q    +  A
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407

Query: 972  SQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER-------------AEMSTEI 1018
              +LE+ +    QE  ++   L+ +++  ++ C    +++             A+ + E 
Sbjct: 1408 YDKLEKTKTRLQQELDDL---LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464

Query: 1019 SRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQ-----QGEQLLEENGDV- 1072
             R +++ +E +  T  LS+ ++      EE +E    L  L      + E L+    DV 
Sbjct: 1465 DRAEAEAREKE--TKALSLARA-----LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517

Query: 1073 -----LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE 1127
                 L   +RA EQ V+E   M T++  L+  LQ  E   +      +     F    +
Sbjct: 1518 KSVHELEKSKRALEQQVEE---MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574

Query: 1128 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1187
              +   ++ + + V  V  R + ++LED+  R   S   ++ ++ E+ +++ EA      
Sbjct: 1575 GRDEQSEEKKKQLVRQV--REMEAELEDE--RKQRSMAVAARKKLEMDLKDLEA------ 1624

Query: 1188 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-- 1245
             ++++ + R E+ +   Q+ +LQ Q+     + D     ++++L      +KKLK +E  
Sbjct: 1625 HIDSANKNRDEAIK---QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681

Query: 1246 --RIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1303
              ++ E     +       +E D L +E+     +   ALE  + L A + +L++EL++ 
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741

Query: 1304 EEVTE-----------------TFLSLEKSY--------DEVKIENEELNVLVLRLQGKI 1338
            +  TE                 T L+LE+S+         +++ +N+EL V +  ++G +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801

Query: 1339 -------------------EKLQESVVQRCDCC----LWEASLENLEIEPDG---NILQL 1372
                               E+L     +R   C      E  L+++ ++ D    N  Q 
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861

Query: 1373 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEK 1409
                ++   R++ +   +EE ++E Q    + + L++
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898



 Score =  141 bits (355), Expect = 8e-33
 Identities = 230/1020 (22%), Positives = 447/1020 (43%), Gaps = 181/1020 (17%)

Query: 313  VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 372
            +E++    + + +E  Q IL+  +  L     L E  +A E    +T+      +LA  K
Sbjct: 964  LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA-EFTTNLTEEEEKSKSLAKLK 1022

Query: 373  AEIRHLLERVDQVVREKEKLRSDLDKAEK----------------------LKSLMASEV 410
             +   ++  +++ +R +EK R +L+K  +                      LK  +A + 
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082

Query: 411  DDHHAAIERRNE------YNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQE 464
            ++  AA+ R  E        L+K+  E + +I+ L+ +L  ER     +A KQ+ +L +E
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERAS-RNKAEKQKRDLGEE 1140

Query: 465  IEKAKTEENYIRDRLALSLKENSRLENEL-------------------------LENAEK 499
            +E  KTE     D  A   +  S+ E E+                          +  E+
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200

Query: 500  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 559
            LAE    T +++ NLE         L+    E   + + L Q + + E + + ++ Q+ E
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQ----TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256

Query: 560  LQSELEEYRAQGRVLRLPLKNSPSE-EVEA-NSGGIEPEHGLGSEECNPLNMSIEAELV- 616
            LQ +  E    G  +R  L +  ++ +VE  N  G+  +    S +      ++E++L  
Sbjct: 1257 LQVKFNE----GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312

Query: 617  IEQMKEQHHRDICCLRLEL---EDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEK 673
             +++ ++ +R    L  +L   ED+   + +QL+E        +E  K   E +  TL  
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE--------EEEAKHNLEKQIATLHA 1364

Query: 674  QISDLKNEIAELQGQAAVLKEAHH------EATCRHEEEKKQLQVKLEEEKTHLQEKL-- 725
            Q++D+K ++ +  G     +E         E   +  EEK     KLE+ KT LQ++L  
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424

Query: 726  ---RLQHEMELKARLTQAQASFER--------------EREGLQSSAWTEE-KVRGLTQE 767
                L H+ +    L + Q  F++              ER+  ++ A  +E K   L + 
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484

Query: 768  LEQFHQE--QLTSLVEKHTLEKEEL--RKELLEKHQRELQEGREKMETECNRRTSQIEAQ 823
            LE+  ++  +L  L ++   E E+L   K+ + K   EL++ +  +E +     +Q+E +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-E 1543

Query: 824  FQSDCQKVTE---RCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 880
             + + Q   +   R E  LQ+++ ++ ++L+   EQ  E+K Q       L ++  E + 
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ-------LVRQVREMEA 1596

Query: 881  LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLS 940
             L++  +++++ ++   ++ EM  K  + H++S    R + ++ L  L       Q+ + 
Sbjct: 1597 ELEDE-RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-------QAQMK 1648

Query: 941  DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 1000
            D + EL  +       REE+L QA  +E    ++L+ +E E  Q ++E    L A E   
Sbjct: 1649 DCMRELDDTR----ASREEILAQAKENE----KKLKSMEAEMIQLQEE----LAAAERAK 1696

Query: 1001 KATCETADRERAEMSTEISRLQSK----IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1056
            +     A +ER E++ EI+    K    ++E ++  + ++ L+        EE +G+  L
Sbjct: 1697 R----QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL-----EEEQGNTEL 1747

Query: 1057 ---SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATE--ISRLQQRLQKLEPGLVMS 1111
                L +   Q+ + N D  L+L+R+H Q   EN +   E     L+ +LQ++E G V S
Sbjct: 1748 INDRLKKANLQIDQINTD--LNLERSHAQK-NENARQQLERQNKELKVKLQEME-GTVKS 1803

Query: 1112 ------SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR--RHVLSDLEDD------- 1156
                  + L+    +       +T+   +Q   KQV    +  + VL  ++D+       
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKE--RQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861

Query: 1157 -EVRDLGSTGTSSVQRQ-EVKIEESEASVEGFSELENSEETRTESWELKN-QISQLQEQL 1213
             +  D  ST    ++RQ E   EE++ +     +L+   E  TE+ +  N ++S L+ +L
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  113 bits (282), Expect = 2e-24
 Identities = 253/1270 (19%), Positives = 499/1270 (39%), Gaps = 248/1270 (19%)

Query: 873  QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 932
            Q C       K   KR++  + +     ++L++    +L     +  +L   ++ L  VS
Sbjct: 787  QACCRGYLARKAFAKRQQQLTAM-----KVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVS 841

Query: 933  ETQQSLLSDQ-----ILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 987
              ++ +++ +     + E + + +  L E E +  Q  A E+L  Q   + E E   E +
Sbjct: 842  RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAE 900

Query: 988  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSML----QSGCQ 1043
            E+ ++L A +   +  C   +    E       LQ++ K+MQQ    L       +S  Q
Sbjct: 901  ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960

Query: 1044 VIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQK 1103
             +  E+V  +  L  L++ + +LE+                 +N K+A E   L+ R+  
Sbjct: 961  KLQLEKVTTEAKLKKLEEEQIILED-----------------QNCKLAKEKKLLEDRI-- 1001

Query: 1104 LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH--VLSDLEDDEVRDL 1161
                            EF  N  E+ E      ++K +  +  +H  +++DLE+   R+ 
Sbjct: 1002 ---------------AEFTTNLTEEEE------KSKSLAKLKNKHEAMITDLEERLRRE- 1039

Query: 1162 GSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCD 1221
                    ++Q  ++E++   +EG            +S +L +QI++LQ Q+  L     
Sbjct: 1040 --------EKQRQELEKTRRKLEG------------DSTDLSDQIAELQAQIAELKMQLA 1079

Query: 1222 RASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
            +  E+ Q  L  V     +  M      A  K + L   +S     LQE+L       ++
Sbjct: 1080 KKEEELQAALARVEEEAAQKNM------ALKKIRELESQISE----LQEDLESERASRNK 1129

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKL 1341
            A +  ++L  E+  L+ EL+   + T     L    ++      E+N+L   L+ + +  
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ------EVNILKKTLEEEAKT- 1182

Query: 1342 QESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLE 1401
                         EA ++ +  +    + +L + LE+     + V   +E+ KQ  +   
Sbjct: 1183 ------------HEAQIQEMRQKHSQAVEELAEQLEQ----TKRVKANLEKAKQTLENER 1226

Query: 1402 GNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELE 1461
            G  +L  +VK      L G   +  +R +V+ Q        L   Q K  + +    EL 
Sbjct: 1227 G--ELANEVKV----LLQGKGDSEHKRKKVEAQ--------LQELQVKFNEGERVRTELA 1272

Query: 1462 LEKTKLQ-ELTRKLKERVTILVKQKDVLSHGEKEE--ELKAMMHDLQITCSEMQQKVELL 1518
             + TKLQ EL     + VT L+ Q D  S    ++   L++ + D Q    E  ++   L
Sbjct: 1273 DKVTKLQVEL-----DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327

Query: 1519 RYESEKLQQENSILRNEITTLNEEDSISNLK--LGTLNGSQEEMWQKTE-------TVKQ 1569
              + ++++ E +  R ++    EE++  NL+  + TL+    +M +K E       T ++
Sbjct: 1328 STKLKQVEDEKNSFREQLE--EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385

Query: 1570 ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQK----------NSQNQEKLQELNQR 1619
                +QK +E L ++  E      +L+   T L Q+            Q+   L++  ++
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445

Query: 1620 LTEMLCQ-------------------KEKEPGNSALEEREQEKFNLKEELERCKVQSSTL 1660
              ++L +                   +EKE    +L    +E    K ELER   Q  T 
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505

Query: 1661 VSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLK 1720
            +  L +   +V    H +++    L+ ++E+MK                           
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK--------------------------T 1539

Query: 1721 EKEALSEELNSCVD-KLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLED 1779
            + E L +EL +  D KL     L+   A  +++ +  + QS   K QLV    +V+ +E 
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV---RQVREMEA 1596

Query: 1780 TVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQ 1839
             +++   Q S   +  +  + + + L+  + S +K            E       L  Q 
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN---------RDEAIKQLRKLQAQM 1647

Query: 1840 KRLSWDKLDHLMNEEQQLLWQ--ENER----LQTMVQNTKAELTHSREKVRQLESNLLPK 1893
            K     +LD      +++L Q  ENE+    ++  +   + EL  +    RQ +      
Sbjct: 1648 KD-CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706

Query: 1894 HQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK 1953
              +  N SG      +EK  L+    Q ++E             LE+E     L N+ LK
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEE-------------LEEEQGNTELINDRLK 1753

Query: 1954 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ------LQRQL 2007
            K  +++D+   ++   RS A  + +      Q L++Q   +  + Q ++       +  +
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENAR----QQLERQNKELKVKLQEMEGTVKSKYKASI 1809

Query: 2008 LQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQE----- 2062
               E     L+E+L+N T E         +    +++ +++V+ + +  ++   +     
Sbjct: 1810 TALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869

Query: 2063 -KVNQLKEQV 2071
             ++ QLK Q+
Sbjct: 1870 TRLKQLKRQL 1879


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  157 bits (396), Expect = 1e-37
 Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)

Query: 760  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 840  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 820  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 877
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 878  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 930
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 931  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 990
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1015 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 991  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1049
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1124

Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1178

Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1162
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 1163 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1295

Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1279
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1352

Query: 1280 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1332
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412

Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1390
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1449
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1523

Query: 1450 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1490
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583

Query: 1491 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1544
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 1545 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 1593 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1649
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1758

Query: 1650 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1703
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1875

Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+     S
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935

Query: 1824 WAP 1826
            + P
Sbjct: 1936 FVP 1938



 Score =  149 bits (377), Expect = 2e-35
 Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)

Query: 433  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 851  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 493  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 951

Query: 553  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 612
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 952  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1000

Query: 613  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 659
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1001 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 660  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1107

Query: 720  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1108 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1155

Query: 780  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 839
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1156 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1212

Query: 840  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 899
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1213 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1261

Query: 900  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 954
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1317

Query: 955  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1014
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1366

Query: 1015 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1416

Query: 1075 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1134
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 1135 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1477 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534

Query: 1194 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1244
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594

Query: 1245 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1297
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1595 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651

Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1652 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1707

Query: 1358 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1411
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 1412 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1825

Query: 1467 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1514
            L+E      + K+  T  +KQKD     +L   E E    E+ K           +++++
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885

Query: 1515 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1574
            +E    ES+++      L+ E+    E +     ++  L  S+     +T  V    +  
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1944

Query: 1575 QKMVENLKKQISELKIKNQQLDLENTELSQ 1604
            ++++EN     SE +   +  D   T+ S+
Sbjct: 1945 RRVIENADG--SEEETDTRDADFNGTKASE 1972



 Score =  148 bits (374), Expect = 5e-35
 Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)

Query: 351  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 856  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 909

Query: 411  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 459
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 910  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969

Query: 460  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 508
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 970  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1026

Query: 509  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 564
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 565  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 604
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 605  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 659  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1262

Query: 716  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 753
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322

Query: 754  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 813  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 857
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 858  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 895
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1497

Query: 896  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1553

Query: 953  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613

Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1614 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1657

Query: 1073 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1117
               L+ A           KEN K A     ++ +LQ+ L   E       L      +E 
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717

Query: 1118 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1166
            A+   G  A Q E    + R  Q           +E ++ R   +  + +++ +  +T  
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777

Query: 1167 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1220
            S+ Q+ E   ++ E   +       E+E + +++ +S    L+ +I+QL+EQ+     + 
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837

Query: 1221 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1269
              A+    +K + L   +  ++ + KM E+  E + K        K   E+   E+  + 
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897

Query: 1270 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1326
               R ++   DEA E+N+ +  EV  L+ +L++  E   +F+   +S     IEN +
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1952



 Score =  139 bits (351), Expect = 2e-32
 Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)

Query: 560  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 619
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 620  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 679
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 956

Query: 680  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 739
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1010

Query: 740  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1011 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1057

Query: 800  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1058 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116

Query: 860  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 917
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1117 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1167

Query: 918  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 976
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227

Query: 977  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287

Query: 1024 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1068
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1345

Query: 1069 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1346 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1184
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461

Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1462 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 1245 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1304
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1517 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 1305 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1358
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1418
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1627 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1671

Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1477
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1672 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724

Query: 1478 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1725 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1828

Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1652
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888

Query: 1653 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1691
             + +S  + ++   L+ EL E       + +E + LK +L +
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score =  110 bits (276), Expect = 1e-23
 Identities = 221/1124 (19%), Positives = 459/1124 (40%), Gaps = 145/1124 (12%)

Query: 1020 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1076
            RL +K+K + Q T     +Q+     Q   E + + +  L  L+Q    L E  ++L   
Sbjct: 836  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 1077 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1136
             +A  +   E  +M   ++  +Q L+++     M + L+E                 +++
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 936

Query: 1137 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1196
            R +Q++   ++     L+ +E  +        +Q ++V  E     +E    + + +  +
Sbjct: 937  RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996

Query: 1197 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
                 L  +   L+E++  L  +     EK ++L         KLK       +  + +L
Sbjct: 997  -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1043

Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
              E+ SR+   L++  R +E    +  E   +L A++  L+ +L K EE  E   +L + 
Sbjct: 1044 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1099

Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
             DE+  +N  L   +  L+G I  LQE +  +R      E    +L  E +    +L  T
Sbjct: 1100 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158

Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1435
            L+    +           K+E +       L E+ ++HE            +  R ++  
Sbjct: 1159 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1203

Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
             +EE T  L       Q +   A L+  K  L++    L   + +L + K  + H  K++
Sbjct: 1204 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1255

Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1547
            +L+A + +LQ  CS+ ++    L  +  KLQ E        N      I    +  S+S+
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 1548 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
                T    QEE  QK   V  +   +++   +L+ Q+ E     Q L+   + L+ + S
Sbjct: 1316 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 1608 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1654
             +++KLQ+               Q+  E L Q+ +E   +A ++ E+ K  L++EL+   
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1433

Query: 1655 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1707
            V       LVS+LE +  + K    + +++N   K  DE ++ +   R  +       + 
Sbjct: 1434 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
            +   L   E+L +  + L  E+    D ++    +   +  +++ +++ E Q   +K+QL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548

Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1821
               ++++Q  ED    + + M  +K     DL+   ++ E  ++++   LH+ + +    
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608

Query: 1822 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR- 1880
            +      A     L    K L       +   E+ +  ++  +LQ  +++ + EL  +R 
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1666

Query: 1881 -------------EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQ 1920
                         +K + LE++L+   +            + EK  L  E        + 
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726

Query: 1921 FQKEQSPANRKVSQMNS-LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1979
             Q E+     +++Q+   LE+E   +   ++ ++K   + ++   E+   RSTA  + S 
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 1980 HAWDLQLLQQQACPMVPREQFLQ------LQRQLLQAERINQHLQEELENRTSETNTPQG 2033
                 Q L++Q   +  +   ++       +  +   E     L+E++E    E      
Sbjct: 1787 R----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842

Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE------KVNQLKEQV 2071
            + +Q    ++E +++VE + K+ ++  ++      +V QLK Q+
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886



 Score =  106 bits (264), Expect = 3e-22
 Identities = 210/977 (21%), Positives = 408/977 (41%), Gaps = 126/977 (12%)

Query: 1169 VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQ 1228
            V RQE +++  E  ++   E +   E   +  EL+ + SQL E+  +L          ++
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKAENELK--ELEQKHSQLTEEKNLL----------QE 894

Query: 1229 DLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKE 1288
             L  +  +  +  +M  R+  A+ K +L  E++  E +   EE    E R  +     K+
Sbjct: 895  QLQAETELYAEAEEMRVRL--AAKKQEL--EEILHEMEARLEE---EEDRGQQLQAERKK 947

Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG-KIEKLQESVVQ 1347
            +  ++  L+++L++ EE     L LEK   E KI+  E  +LV+  Q  K+ K ++ + +
Sbjct: 948  MAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006

Query: 1348 RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL 1407
            R        + E    E   N+ +L    E           +I E +   +  E + Q L
Sbjct: 1007 RISDLTTNLAEEE---EKAKNLTKLKNKHES----------MISELEVRLKKEEKSRQEL 1053

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-- 1465
            EK+K      L G      E+       I E    L     K  + QA +A L+ E    
Sbjct: 1054 EKLKRK----LEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEIAQK 1106

Query: 1466 -----KLQELTRKLKERVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKV 1515
                 K++EL   + +    L  ++   +  EK+     EEL+A+  +L+ T      + 
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166

Query: 1516 ELLRYESEKLQQENSILRNEIT--TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAA 1573
            EL      K +QE ++L+  +   T + E  +  ++      + EE+ ++ E  K+  A 
Sbjct: 1167 EL----RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKAN 1221

Query: 1574 VQKMVENLKKQISEL--------------KIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
            + K  + L+K+ ++L              + K ++L+ +  EL  K S  +    ELN +
Sbjct: 1222 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281

Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE---VKIQTH 1676
            + ++  Q E E     L E E +   L +++     Q       L+ E  +   V  +  
Sbjct: 1282 VHKL--QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339

Query: 1677 IVQQENHLLKDELEKMKQLHRCPD---------LSDFQQKISSVLSYNEKLLKEKEALSE 1727
             +++E + L+D+L++  +  +  +         LSD ++K+    S  E L + K+   +
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399

Query: 1728 ELNSCVDKLAKSSLLEHRIATMKQE-QKSWEHQSASLKSQ--LVASQEKVQNLEDTVQNV 1784
            E+ +   +  + +    ++   K   Q+  +     L +Q  LV++ EK Q   D +   
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 1785 NLQMSRMKSDLRVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
               +S   +D R  + E EA ++E   +SL + L+ A       E+      L  + + L
Sbjct: 1460 EKNISSKYADER-DRAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDL 1516

Query: 1843 SWDKLD-----HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP-KHQK 1896
               K D     H + + ++ L  + E ++T ++  + EL  + +   +LE N+   K Q 
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 1897 HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK----VSQMNSLEQELETIHLENEGL 1952
              +        E+++  L+R+  +++ E     ++     +    LE +L+ + L+ +  
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636

Query: 1953 KK------KQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQR 2005
             K      KQ+ KL  Q+ + Q     A  S        +  +++A  +      +QLQ 
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQE 1694

Query: 2006 QLLQAERIN-------QHLQEELENRTSETNTPQGNQEQL---VTVMEERMIEVEQKLKL 2055
             L  AER         + L EEL +  S  N  Q  + +L   +  +EE + E +  ++ 
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 2056 VKRLLQEKVNQLKEQVS 2072
            +   ++ K  Q  EQ+S
Sbjct: 1755 MSDRVR-KATQQAEQLS 1770



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)

Query: 329  QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 386
            +E+ + L  SL G   L +    LE  +   +  +   Q  + +    +R   ++ +Q+ 
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 387  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 439
             E    RS   K E  +             +ER+N+    KL E       ++K  IAAL
Sbjct: 1771 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 440  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 499
            + ++ +  EQ+ Q+A +     +Q   K+  +++     + L +++  ++  +  E AEK
Sbjct: 1820 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874

Query: 500  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 559
                     +L+R LE        + +  S        +L +  +E       +  +V+ 
Sbjct: 1875 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923

Query: 560  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
            L+S+L   R       +P + S    V  N+ G E E
Sbjct: 1924 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1957


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  157 bits (396), Expect = 1e-37
 Identities = 226/1143 (19%), Positives = 502/1143 (43%), Gaps = 120/1143 (10%)

Query: 760  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 847  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 820  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 877
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 878  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 930
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 931  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 990
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1022 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 991  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1049
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1131

Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1185

Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1162
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 1163 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1302

Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1279
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1359

Query: 1280 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1332
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419

Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1390
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1449
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1530

Query: 1450 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1490
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 1491 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1544
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 1545 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 1593 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1649
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1765

Query: 1650 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1703
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1882

Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKS 1823
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+     S
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942

Query: 1824 WAP 1826
            + P
Sbjct: 1943 FVP 1945



 Score =  149 bits (377), Expect = 2e-35
 Identities = 252/1230 (20%), Positives = 513/1230 (41%), Gaps = 166/1230 (13%)

Query: 433  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 858  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 493  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 958

Query: 553  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 612
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 959  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1007

Query: 613  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 659
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1008 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 660  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1114

Query: 720  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1115 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1162

Query: 780  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 839
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1163 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219

Query: 840  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 899
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1220 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1268

Query: 900  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 954
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1324

Query: 955  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1014
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1373

Query: 1015 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1423

Query: 1075 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1134
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 1135 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1484 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 1194 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1244
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601

Query: 1245 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1297
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1602 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658

Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1659 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1714

Query: 1358 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1411
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 1412 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1832

Query: 1467 LQELTR---KLKERVTILVKQKD-----VLSHGEKE----EELKAMMHDLQITCSEMQQK 1514
            L+E      + K+  T  +KQKD     +L   E E    E+ K           +++++
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892

Query: 1515 VELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAV 1574
            +E    ES+++      L+ E+    E +     ++  L  S+     +T  V    +  
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK-SKLRRGNETSFVPSRRSGG 1951

Query: 1575 QKMVENLKKQISELKIKNQQLDLENTELSQ 1604
            ++++EN     SE +   +  D   T+ S+
Sbjct: 1952 RRVIENADG--SEEETDTRDADFNGTKASE 1979



 Score =  148 bits (374), Expect = 5e-35
 Identities = 253/1137 (22%), Positives = 493/1137 (43%), Gaps = 201/1137 (17%)

Query: 351  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 863  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 916

Query: 411  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 459
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976

Query: 460  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 508
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 977  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1033

Query: 509  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 564
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 565  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 604
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 605  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 659  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1269

Query: 716  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 753
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 754  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 813  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 857
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 858  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 895
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1504

Query: 896  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560

Query: 953  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620

Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1621 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1664

Query: 1073 LLSLQRAHEQ------AVKENVKMA----TEISRLQQRLQKLE-----PGLVMSSCLDEP 1117
               L+ A           KEN K A     ++ +LQ+ L   E       L      +E 
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724

Query: 1118 ATEFFGNTAEQTEPFLQQNRTKQ-----------VEGVTRRHVLSDLEDDEVRDLGSTGT 1166
            A+   G  A Q E    + R  Q           +E ++ R   +  + +++ +  +T  
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784

Query: 1167 SSVQRQEVKIEESEASVE----GFSELENSEETRTESW--ELKNQISQLQEQLMMLCADC 1220
            S+ Q+ E   ++ E   +       E+E + +++ +S    L+ +I+QL+EQ+     + 
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844

Query: 1221 DRAS----EKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYEDVSRENDCLQ 1269
              A+    +K + L   +  ++ + KM E+  E + K        K   E+   E+  + 
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904

Query: 1270 EELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1326
               R ++   DEA E+N+ +  EV  L+ +L++  E   +F+   +S     IEN +
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET--SFVPSRRSGGRRVIENAD 1959



 Score =  139 bits (351), Expect = 2e-32
 Identities = 242/1182 (20%), Positives = 493/1182 (41%), Gaps = 146/1182 (12%)

Query: 560  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 619
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 620  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 679
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 963

Query: 680  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 739
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1017

Query: 740  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1018 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1064

Query: 800  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1065 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123

Query: 860  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 917
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1124 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1174

Query: 918  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 976
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234

Query: 977  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294

Query: 1024 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1068
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1352

Query: 1069 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1353 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1184
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1469 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 1245 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1304
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1524 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 1305 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1358
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1418
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1634 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1678

Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1477
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1679 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731

Query: 1478 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1732 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1835

Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1652
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 1653 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDELEK 1691
             + +S  + ++   L+ EL E       + +E + LK +L +
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score =  110 bits (276), Expect = 1e-23
 Identities = 221/1124 (19%), Positives = 459/1124 (40%), Gaps = 145/1124 (12%)

Query: 1020 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1076
            RL +K+K + Q T     +Q+     Q   E + + +  L  L+Q    L E  ++L   
Sbjct: 843  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 1077 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1136
             +A  +   E  +M   ++  +Q L+++     M + L+E                 +++
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 943

Query: 1137 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1196
            R +Q++   ++     L+ +E  +        +Q ++V  E     +E    + + +  +
Sbjct: 944  RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003

Query: 1197 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
                 L  +   L+E++  L  +     EK ++L         KLK       +  + +L
Sbjct: 1004 -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1050

Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
              E+ SR+   L++  R +E    +  E   +L A++  L+ +L K EE  E   +L + 
Sbjct: 1051 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1106

Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
             DE+  +N  L   +  L+G I  LQE +  +R      E    +L  E +    +L  T
Sbjct: 1107 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165

Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1435
            L+    +           K+E +       L E+ ++HE            +  R ++  
Sbjct: 1166 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1210

Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
             +EE T  L       Q +   A L+  K  L++    L   + +L + K  + H  K++
Sbjct: 1211 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1262

Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1547
            +L+A + +LQ  CS+ ++    L  +  KLQ E        N      I    +  S+S+
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 1548 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
                T    QEE  QK   V  +   +++   +L+ Q+ E     Q L+   + L+ + S
Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 1608 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1654
             +++KLQ+               Q+  E L Q+ +E   +A ++ E+ K  L++EL+   
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1440

Query: 1655 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1707
            V       LVS+LE +  + K    + +++N   K  DE ++ +   R  +       + 
Sbjct: 1441 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
            +   L   E+L +  + L  E+    D ++    +   +  +++ +++ E Q   +K+QL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555

Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1821
               ++++Q  ED    + + M  +K     DL+   ++ E  ++++   LH+ + +    
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615

Query: 1822 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR- 1880
            +      A     L    K L       +   E+ +  ++  +LQ  +++ + EL  +R 
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1673

Query: 1881 -------------EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQ 1920
                         +K + LE++L+   +            + EK  L  E        + 
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733

Query: 1921 FQKEQSPANRKVSQMNS-LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1979
             Q E+     +++Q+   LE+E   +   ++ ++K   + ++   E+   RSTA  + S 
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 1980 HAWDLQLLQQQACPMVPREQFLQ------LQRQLLQAERINQHLQEELENRTSETNTPQG 2033
                 Q L++Q   +  +   ++       +  +   E     L+E++E    E      
Sbjct: 1794 R----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849

Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE------KVNQLKEQV 2071
            + +Q    ++E +++VE + K+ ++  ++      +V QLK Q+
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893



 Score =  106 bits (264), Expect = 3e-22
 Identities = 210/977 (21%), Positives = 408/977 (41%), Gaps = 126/977 (12%)

Query: 1169 VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQ 1228
            V RQE +++  E  ++   E +   E   +  EL+ + SQL E+  +L          ++
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKAENELK--ELEQKHSQLTEEKNLL----------QE 901

Query: 1229 DLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKE 1288
             L  +  +  +  +M  R+  A+ K +L  E++  E +   EE    E R  +     K+
Sbjct: 902  QLQAETELYAEAEEMRVRL--AAKKQEL--EEILHEMEARLEE---EEDRGQQLQAERKK 954

Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG-KIEKLQESVVQ 1347
            +  ++  L+++L++ EE     L LEK   E KI+  E  +LV+  Q  K+ K ++ + +
Sbjct: 955  MAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 1348 RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL 1407
            R        + E    E   N+ +L    E           +I E +   +  E + Q L
Sbjct: 1014 RISDLTTNLAEEE---EKAKNLTKLKNKHES----------MISELEVRLKKEEKSRQEL 1060

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-- 1465
            EK+K      L G      E+       I E    L     K  + QA +A L+ E    
Sbjct: 1061 EKLKRK----LEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEIAQK 1113

Query: 1466 -----KLQELTRKLKERVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKV 1515
                 K++EL   + +    L  ++   +  EK+     EEL+A+  +L+ T      + 
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173

Query: 1516 ELLRYESEKLQQENSILRNEIT--TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAA 1573
            EL      K +QE ++L+  +   T + E  +  ++      + EE+ ++ E  K+  A 
Sbjct: 1174 EL----RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKAN 1228

Query: 1574 VQKMVENLKKQISEL--------------KIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
            + K  + L+K+ ++L              + K ++L+ +  EL  K S  +    ELN +
Sbjct: 1229 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288

Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE---VKIQTH 1676
            + ++  Q E E     L E E +   L +++     Q       L+ E  +   V  +  
Sbjct: 1289 VHKL--QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346

Query: 1677 IVQQENHLLKDELEKMKQLHRCPD---------LSDFQQKISSVLSYNEKLLKEKEALSE 1727
             +++E + L+D+L++  +  +  +         LSD ++K+    S  E L + K+   +
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 1728 ELNSCVDKLAKSSLLEHRIATMKQE-QKSWEHQSASLKSQ--LVASQEKVQNLEDTVQNV 1784
            E+ +   +  + +    ++   K   Q+  +     L +Q  LV++ EK Q   D +   
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 1785 NLQMSRMKSDLRVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
               +S   +D R  + E EA ++E   +SL + L+ A       E+      L  + + L
Sbjct: 1467 EKNISSKYADER-DRAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDL 1523

Query: 1843 SWDKLD-----HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP-KHQK 1896
               K D     H + + ++ L  + E ++T ++  + EL  + +   +LE N+   K Q 
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 1897 HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK----VSQMNSLEQELETIHLENEGL 1952
              +        E+++  L+R+  +++ E     ++     +    LE +L+ + L+ +  
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643

Query: 1953 KK------KQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQR 2005
             K      KQ+ KL  Q+ + Q     A  S        +  +++A  +      +QLQ 
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQE 1701

Query: 2006 QLLQAERIN-------QHLQEELENRTSETNTPQGNQEQL---VTVMEERMIEVEQKLKL 2055
             L  AER         + L EEL +  S  N  Q  + +L   +  +EE + E +  ++ 
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 2056 VKRLLQEKVNQLKEQVS 2072
            +   ++ K  Q  EQ+S
Sbjct: 1762 MSDRVR-KATQQAEQLS 1777



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 39/277 (14%)

Query: 329  QEILKALDFSLDGNINLTELTLALENELLVTKNSIH--QAALASFKAEIRHLLERVDQVV 386
            +E+ + L  SL G   L +    LE  +   +  +   Q  + +    +R   ++ +Q+ 
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 387  REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE-------EYKERIAAL 439
             E    RS   K E  +             +ER+N+    KL E       ++K  IAAL
Sbjct: 1778 NELATERSTAQKNESARQ-----------QLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 440  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 499
            + ++ +  EQ+ Q+A +     +Q   K+  +++     + L +++  ++  +  E AEK
Sbjct: 1827 EAKIAQLEEQVEQEARE-----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881

Query: 500  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE 559
                     +L+R LE        + +  S        +L +  +E       +  +V+ 
Sbjct: 1882 ---GNARVKQLKRQLE--------EAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930

Query: 560  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
            L+S+L   R       +P + S    V  N+ G E E
Sbjct: 1931 LKSKL---RRGNETSFVPSRRSGGRRVIENADGSEEE 1964


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score =  155 bits (393), Expect = 3e-37
 Identities = 379/1840 (20%), Positives = 758/1840 (41%), Gaps = 310/1840 (16%)

Query: 340  DGNINLTELTLALENELLVT-KNSIHQAALASFKAEIRHLLERVDQVVREKEKLR----S 394
            +G+++    +   E++++V  K S     +     + + +L+ +  V +E   LR    S
Sbjct: 1032 EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPS 1090

Query: 395  DLDKAEKLKSLMASEVDDHHAAIERRN-----------EYNLRKLDEEYKERIAALKNEL 443
            + DK +K  +++ SE +D    +E +            +     ++ E  + + +LK EL
Sbjct: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150

Query: 444  RKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR-LALSLKENSRLENE-----LLENA 497
               +E+ +++  K     + E++  KT+E     + L L + +  +  +E     L    
Sbjct: 1151 IFAQEEKIKELQKIH---QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207

Query: 498  EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 557
              L EY     K + N E+   E  GD    + +  LQ+ R      +++     L ++V
Sbjct: 1208 SVLGEYYTPALKCEVNAED--KENSGDYISENEDPELQDYRYEVQ--DFQENMHTLLNKV 1263

Query: 558  DE-------LQSELEEYRAQ---GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
             E       LQ+ L +   Q   G  L    +N P EE E                    
Sbjct: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF------------------- 1304

Query: 608  NMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 666
             +SI +++  +E +   H   +  L+   + K+    ++L+  + S ++  +  +Q +E 
Sbjct: 1305 -LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEA 1363

Query: 667  ETHTLEKQISDLKNEIA--ELQGQAAVLKEAHHEATCRHEE-EKKQLQVKLE-------E 716
            E H L+K++  +        L   + V+ E+  + T       KK +   +E       +
Sbjct: 1364 EIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVK 1423

Query: 717  EKTHLQEKLRLQHEMELKARLTQA----------QASFEREREGLQSSAWTEEKVRGLTQ 766
            E+T++ + L  Q++ +L+  + +           Q    R   G +++A +++      Q
Sbjct: 1424 EETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQ 1483

Query: 767  ELEQFHQEQLTS-LVEKHTLEKEELR-KELLEKHQRELQE-GREKMETECNRRTSQIEAQ 823
            E   F++ +L+   +   T E  +++ KE  +   +EL E G+E + +  +      +  
Sbjct: 1484 EQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----DIP 1539

Query: 824  FQSDCQ-KVTERCES------ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT---Q 873
               DC   ++E   S        QS+         D   Q    + Q E  + EL    Q
Sbjct: 1540 ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQ 1599

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 933
            E  +A ELL++   R+        +++E L++  K  LN  + +R  +  D E+L  VSE
Sbjct: 1600 EHQQATELLRQAHMRQMERQ---REDQEQLQEEIKR-LNRQLAQRSSI--DNENL--VSE 1651

Query: 934  TQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL 993
             ++ LL     EL++  +  L  RE++ C+   S   ++Q     E + + E Q    K 
Sbjct: 1652 RERVLLE----ELEALKQLSLAGREKLCCELRNS---STQTQNGNENQGEVEEQTFKEKE 1704

Query: 994  LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGD 1053
            L  +       E    ER  +    +RL   + E+ + T+ +            EE  G 
Sbjct: 1705 LDRKP-EDVPPEILSNERYALQKANNRLLKILLEVVKTTAAV------------EETIGR 1751

Query: 1054 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSC 1113
              L +L +  +         L  +   E +VK  V    E +R+                
Sbjct: 1752 HVLGILDRSSK---SQSSASLIWRSEAEASVKSCVH--EEHTRVT--------------- 1791

Query: 1114 LDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE----DDEVRDLGSTGTSSV 1169
             DE    + G+   + +  +    T++   +++R V S       D E  +L    +S +
Sbjct: 1792 -DESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850

Query: 1170 QRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQD 1229
            Q    K+   EA  E  S+LE+++ T+TE   ++    Q QE           A+E    
Sbjct: 1851 QAAVEKL--LEAISETSSQLEHAKVTQTEL--MRESFRQKQE-----------ATES--- 1892

Query: 1230 LLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREN---DCLQEELRMMETRYDEALENN 1286
                   LK + ++ ER+ E S   + L  ++S+     D   +E  + E +  E  +  
Sbjct: 1893 -------LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDII 1945

Query: 1287 KELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVV 1346
              L  E+    + L++          LE    +++ E E L+     ++ +   +++ ++
Sbjct: 1946 DRLEQELLCASNRLQE----------LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995

Query: 1347 QRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL 1406
            Q  +    +   E LE++      Q  +  ++   +V+++   +EE  Q ++++E     
Sbjct: 1996 QETE----KLMKEKLEVQ-----CQAEKVRDDLQKQVKALEIDVEE--QVSRFIE----- 2039

Query: 1407 LEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
            LE+ K  E+  L           R QNQ + ++   +  F D+         + E E+  
Sbjct: 2040 LEQEKNTELMDL-----------RQQNQALEKQLEKMRKFLDEQ------AIDREHERDV 2082

Query: 1467 LQELTRKLKERVTILVKQKDVLSHGEKE-EELKAMMHDLQITCSEMQQKVELLRYESEKL 1525
             Q+  +KL++++ ++ + + +  H  +E E+L   + +    CSE+    E L+ + ++ 
Sbjct: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142

Query: 1526 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
             +E   L   +  L +   +S            + +QK E  K   A   K   +L+ Q+
Sbjct: 2143 NEEIEKLEFRVRELEQALLVS-----------ADTFQKVEDRKHFGAVEAKPELSLEVQL 2191

Query: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE--KEPGNSALEEREQEK 1643
               +    + + E T L ++  Q +E+L+  N+ + ++  Q E  K+   + L+E EQE 
Sbjct: 2192 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQEN 2251

Query: 1644 FNLKEELERCKV------------------QSSTLVSSLEAELSEVKIQTHIVQQENHLL 1685
               K+++E+  +                  + + ++   E E+ ++  Q   +QQ+  + 
Sbjct: 2252 KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2311

Query: 1686 KDE--LEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1743
             D   +E+  +L R     D + +I  ++S  E + + +E   E+LN  ++KL      +
Sbjct: 2312 TDNKVIEEKNELIR-----DLETQIECLMSDQECVKRNREEEIEQLNEVIEKL------Q 2360

Query: 1744 HRIATMKQEQKSWEH----QSASLKSQL-VASQEKVQNLEDTVQNVNLQMSRMKSDLRVT 1798
              +A + Q+     H    ++ SLK QL V   EK+  LE  V+  N +M+ MK+ L+ T
Sbjct: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA-LEQQVETANEEMTFMKNVLKET 2419

Query: 1799 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDK--LDHLMNEEQQ 1856
              +   L QE+ SL ++ ++       PE + + +  H     LS DK  L+ ++ E+  
Sbjct: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDH-----LSKDKPELEVVLTEDAL 2474

Query: 1857 LLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKR 1916
               +     ++  +N K  + +   ++ QLES +  K          +  T+  K  +K 
Sbjct: 2475 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKD---------LELTQCYK-QIKD 2524

Query: 1917 ECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPS 1976
              +Q Q E     +K+  +  + +E     L +      Q++L+      +  +   T S
Sbjct: 2525 MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS------QIQLEAVQEYAKFCQDNQTIS 2578

Query: 1977 PSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQE 2036
              P   ++Q L Q       RE  L      L   RI+     ELE++  E +T    ++
Sbjct: 2579 SEPERTNIQNLNQL------REDELGSDISALTL-RIS-----ELESQVVEMHTSLILEK 2626

Query: 2037 QLVTVMEERMIEVEQKLKLVKRLLQ--EKVNQLKEQVSLP 2074
            + V + E+ ++E E+KL  +++LL+  EK  + KE+   P
Sbjct: 2627 EQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666



 Score =  150 bits (380), Expect = 1e-35
 Identities = 384/1911 (20%), Positives = 764/1911 (39%), Gaps = 300/1911 (15%)

Query: 350  LALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMAS- 408
            L L++   VTK S  +A   S   E   L + ++ +  E+  LR  ++      SL+ S 
Sbjct: 1070 LILDHLPSVTKESSLRATQPS---ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126

Query: 409  EVDDHHAAIERRNEYNLRKLDEEY----KERIAALKN----ELRKEREQILQQAGKQRLE 460
             VD     +E   +  L  L EE     +E+I  L+     EL+  + Q     GK    
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186

Query: 461  LEQEIEKAKTEE-NYIRDRLALSL----------------KENS---------------- 487
            L  +++KA +EE +Y    L   L                KENS                
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246

Query: 488  -----------RLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGD--LDPSSAEFFL 534
                        L N++ E   KL   +   +K+     + +  +FG+  L     EF  
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306

Query: 535  QEERLTQMRN---EYERQCRVLQD-QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANS 590
               ++T + +    ++ +   LQD +  +L+ +++E  +    L+  LK +  +  EA  
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKET-EQNYEAEI 1365

Query: 591  GGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV----------- 639
              ++      SE   P ++ +++ ++ E   ++      C++  ++  +           
Sbjct: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425

Query: 640  --------RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAV 691
                    + Y++QL+E V    K   +M      +T  L +     +N  +  Q  A  
Sbjct: 1426 TNIVKLLEKQYQEQLEEEVA---KVIVSMSIAFAQQTE-LSRISGGKENTASSKQAHAVC 1481

Query: 692  LKEAHHEATCRHEEEK------KQLQVKLEEEKTHLQEKLRLQHEMELKAR--------- 736
             +E H+    +  +++      + + VK +EE   L ++L  +H  E+            
Sbjct: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG-EHGKEILLSNSDPHDIPE 1540

Query: 737  -----LTQAQASFERER---------EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK 782
                 LT ++  F +++         + +  S+    +   L +E  +  +++L    ++
Sbjct: 1541 SKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE 1600

Query: 783  HTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK-VTERCESALQS 841
            H    E LR+  + + +R+ +E +E+++ E  R   Q+  +   D +  V+ER    L+ 
Sbjct: 1601 HQQATELLRQAHMRQMERQ-REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEE 1659

Query: 842  LEGRYRQELKDLQEQQREE------KSQWEFEKDELTQECAEAQELLKETLKR--EKTTS 893
            LE      LK L    RE+       S  + +     Q   E Q   ++ L R  E    
Sbjct: 1660 LEA-----LKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPP 1714

Query: 894  LVLTQEREMLEKTYKEHLNSM--VVERQQLLQD--------LEDLRNVSETQQSLL--SD 941
             +L+ ER  L+K     L  +  VV+    +++        + D  + S++  SL+  S+
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774

Query: 942  QILELKSS-HKRELREREEVLCQAGASEQLA----------------SQRLERLEM---E 981
                +KS  H+   R  +E +     S+                   SQRL R      E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834

Query: 982  HDQERQEMMSKL-----LAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLS 1036
             D E +E+M  +      A+E + +A  ET+ +      T+   ++   ++ Q+AT  L 
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894

Query: 1037 MLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISR 1096
              +   + + EE    +     L + E +++   D     +R  ++      ++  E+  
Sbjct: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954

Query: 1097 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
               RLQ+LE          E  +        +  P ++Q   ++ E + +  +    + +
Sbjct: 1955 ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP-VEQQLLQETEKLMKEKLEVQCQAE 2013

Query: 1157 EVRDLGSTGTSSVQRQEVKIE-ESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM 1215
            +VRD        +Q+Q   +E + E  V  F ELE  +E  TE  +L+ Q   L++QL  
Sbjct: 2014 KVRD-------DLQKQVKALEIDVEEQVSRFIELE--QEKNTELMDLRQQNQALEKQLEK 2064

Query: 1216 LCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1275
            +    D   E+  D   +  V +++++ LE+  +  P+++ + E  +RE + L   L+  
Sbjct: 2065 MRKFLD---EQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121

Query: 1276 ETRYDEALENNKELTAEVFRLQDELKKME-EVTETFLSLEKSYDEVKIENEELNVLVLRL 1334
              +  E L + ++L  ++    +E++K+E  V E   +L  S D  +   +  +   +  
Sbjct: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181

Query: 1335 QGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1394
            + ++    +   +R      E  + NLE + +    Q  + LE     V+ +H  +E  K
Sbjct: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEEQLE----QFREELENKNEEVQQLHMQLEIQK 2237

Query: 1395 QENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF--- 1451
            +E+      T+L E  + +++            +  ++   +  + +  +  QD+H    
Sbjct: 2238 KES-----TTRLQELEQENKLF-----------KDDMEKLGLAIKESDAMSTQDQHVLFG 2281

Query: 1452 QHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEK----EEELKAMMHDLQIT 1507
            +    I E E+E  +L E   KL++++ I    K +    E     E +++ +M D +  
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2341

Query: 1508 CSEMQQKVELLRYESEKLQQENSILRNEIT----TLNEEDSISNLKLGTLNGSQEEMWQK 1563
                ++++E L    EKLQQE + +  + +    +L+EE      +L  +   +  + Q+
Sbjct: 2342 KRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 2401

Query: 1564 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1623
             ET  +E       +  +K  + E   K  QL  E   L ++  ++ EK+Q + +     
Sbjct: 2402 VETANEE-------MTFMKNVLKETNFKMNQLTQELFSLKRER-ESVEKIQSIPENSV-- 2451

Query: 1624 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQS---STLVSSLE--AELSEVKIQTHIV 1678
                     N A++   ++K  L+  L    ++S    T   S E   + S + ++T ++
Sbjct: 2452 ---------NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL 2502

Query: 1679 QQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYN----EKLLKEK-----------E 1723
            Q E+ +   +LE  +   +  D+ +  Q  + +L       +K+++EK           E
Sbjct: 2503 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2562

Query: 1724 ALSEELNSCVDKLAKSSLLEH-RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQ 1782
            A+ E    C D    SS  E   I  + Q ++        L S + A   ++  LE  V 
Sbjct: 2563 AVQEYAKFCQDNQTISSEPERTNIQNLNQLRED------ELGSDISALTLRISELESQVV 2616

Query: 1783 NVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
             ++  +   K  + + ++     +++++ L K L+    K    E    P  +   +   
Sbjct: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK--- 2673

Query: 1843 SWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSG 1902
            +  +L H  + E+   + E E L+     TKAEL   +EK  +L+  LL K         
Sbjct: 2674 TTTELFH--SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK--------- 2722

Query: 1903 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1962
                 E    SL+++  Q +   + A  K+S    LE+E ET     E  + K+  + E 
Sbjct: 2723 -----ETNMTSLQKDLSQVRDHLAEAKEKLS---ILEKEDET-----EVQESKKACMFEP 2769

Query: 1963 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMV-PREQFLQLQRQLLQAERINQHLQEEL 2021
            L  ++  +S A+ +       L++      P +  +   +Q+    LQ+E  ++ + E +
Sbjct: 2770 L-PIKLSKSIASQTDG----TLKISSSNQTPQILVKNAGIQIN---LQSECSSEEVTEII 2821

Query: 2022 ENRTSETNTPQGNQEQLVTVMEERMIEVEQKLK----LVKRLLQEKVNQLK 2068
               T +    Q      +  ME R I   + LK    +  +LL+E+   LK
Sbjct: 2822 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLK 2872



 Score =  146 bits (369), Expect = 2e-34
 Identities = 394/2002 (19%), Positives = 787/2002 (39%), Gaps = 331/2002 (16%)

Query: 327  NSQEILKALDFSLDGNINLTELTLALENELL------VTKNSIHQAALASFKAEIRHLLE 380
            N Q+  +  D ++   + LTE +  L+ +          +NS H +  A      + +L 
Sbjct: 213  NLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272

Query: 381  RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALK 440
               Q+  E++ L  D  K ++  ++  S + +     E   +   +K++   KE I   +
Sbjct: 273  HQQQL-EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD---KKVENSNKEEIQEKE 328

Query: 441  NELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 500
              + +   +I+++  K+ LEL+ ++  A      +++++    +E   ++ EL  + +K 
Sbjct: 329  TIIEELNTKIIEEE-KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKE 387

Query: 501  AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
             +      +L   +E +      D          + + + +M  E +R+   L+ ++DE+
Sbjct: 388  RQSSEEIKQLMGTVEELQKRNHKDSQ-------FETDIVQRMEQETQRKLEQLRAELDEM 440

Query: 561  ---------QSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI--EPEHGLGSEECNPLNM 609
                     Q  + ++ AQ   ++   K      + + S     E +  L +   N LN+
Sbjct: 441  YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500

Query: 610  SIE-AELVIEQMKEQHH---RDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHE 665
             ++      E++KE+      + C L+ +LED V    ++L  +    ++A++ + ++  
Sbjct: 501  KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLV----EELSFSREQIQRARQTIAEQES 556

Query: 666  --NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE---EEKTH 720
              NE H     + DLK EI           E+  E   +HE E    ++KLE   +EK  
Sbjct: 557  KLNEAHKSLSTVEDLKAEIVSAS-------ESRKELELKHEAEVTNYKIKLEMLEKEKNA 609

Query: 721  LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVR--GLTQELEQFHQEQLTS 778
            + +++    E EL+   TQ   S E E   L+     E ++    L   L   +++Q+  
Sbjct: 610  VLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG 669

Query: 779  L-------VEKHTLEKEELR----------KELLEKHQRELQEGREKMETECNRRTSQIE 821
            L       +E    EK+ L            +L +  Q  +    E+M  + N    +IE
Sbjct: 670  LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729

Query: 822  AQFQSDCQKVT-ERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQE 880
               Q + +K T E+    LQ       +++K+ +   +E+ +Q E E   L  E    ++
Sbjct: 730  ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789

Query: 881  LLK--ETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSL 938
            +LK    + +E+    + + + +  +  +++ +  ++ E + L Q    L    E Q++ 
Sbjct: 790  MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849

Query: 939  LSDQ-----------------ILELK-----SSHKRELREREEVLCQAGASEQLASQRLE 976
             S                   +L++K     S +K+EL  + ++      +E+L  QR+ 
Sbjct: 850  FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL---KALNEELHLQRIN 906

Query: 977  RLEME-----HDQERQEMMSKLLAMENIHKATCETAD------RERAEMST--------- 1016
               ++      D+++  +   L   E + K T E  +      RE+ E+S          
Sbjct: 907  PTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQL 966

Query: 1017 -----EISRLQSKIKEMQQATSPLSMLQSGCQVI-----GEEEVEGDGALSLLQQGEQLL 1066
                 EIS L  ++K ++Q    +S+     ++I      E     D  +S L  G   +
Sbjct: 967  KQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTM 1026

Query: 1067 EENG------DVLLSLQRAHEQAVKENVKMAT----EISRLQQRLQKLEPGLVMSSCL-- 1114
               G       V  S     +  V++ V        E S+ +Q +    P +   S L  
Sbjct: 1027 TSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRA 1086

Query: 1115 ------DEPATEFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVLSDLEDDEVRDLGST 1164
                  D+   E     +EQ +  LQ    +     V       V   +E+++ + L S 
Sbjct: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146

Query: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQ--------LMML 1216
                +  QE KI+E +   +   +   ++ET  E   L   I +LQ+         L  L
Sbjct: 1147 KEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206

Query: 1217 CA----------DCDRASEKK---------------QDLLFDVSVLKKKLKMLERIPEAS 1251
            C+           C+  +E K               QD  ++V   ++ +  L  + + +
Sbjct: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTL--LNKVT 1264

Query: 1252 PKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT---E 1308
             +Y  L    +R +    ++   M+  + E  EN  +   E   +  ++  +E++    +
Sbjct: 1265 EEYNKLLVLQTRLSKIWGQQTDGMKLEFGE--ENLPKEETEFLSIHSQMTNLEDIDVNHK 1322

Query: 1309 TFLSLEKSYDEVKIENE--ELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD 1366
            + LS  +  ++ K+E +  EL  L+  LQ ++++ +++         +EA +  L+    
Sbjct: 1323 SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQN---------YEAEIHCLQ---- 1369

Query: 1367 GNILQLNQTLEECVPRVRSVHHV-IEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTH 1425
                +L    E  VP    V  V I E   +     G+      VK +    + GTI+  
Sbjct: 1370 ---KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSC-----VKKN----IDGTIE-- 1415

Query: 1426 QERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK 1485
                    +  ++E T ++   +K +Q Q            L+E   K+   ++I   Q+
Sbjct: 1416 -----FSGEFGVKEETNIVKLLEKQYQEQ------------LEEEVAKVIVSMSIAFAQQ 1458

Query: 1486 DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESE------------KLQQENSILR 1533
              LS     +E  A        C + Q     ++   +            K ++E   L 
Sbjct: 1459 TELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLS 1518

Query: 1534 NEITTLNEEDSISNLKLGTLNGSQ-------EEMWQKTET--VKQ---ENAAVQKMVENL 1581
             E+    +E  +SN     +  S+       EEM+ K +T  V+Q   +  +V  M  + 
Sbjct: 1519 KELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASR 1578

Query: 1582 KKQISELKIKNQQLDL--------ENTEL--------SQKNSQNQEKLQELNQRLTEMLC 1625
            +  ++E ++++ + +L        + TEL         ++  ++QE+LQE  +RL   L 
Sbjct: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638

Query: 1626 QKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLL 1685
            Q+      + + ERE+    L EELE  K  S      L  EL     QT    +    +
Sbjct: 1639 QRSSIDNENLVSERERV---LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695

Query: 1686 KDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLA--KSSLLE 1743
            +++  K K+L R P+  D   +I S   Y   L K    L + L   V   A  + ++  
Sbjct: 1696 EEQTFKEKELDRKPE--DVPPEILSNERY--ALQKANNRLLKILLEVVKTTAAVEETIGR 1751

Query: 1744 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL-RVTQQEK 1802
            H +  + +  KS    S   +S+  AS +   + E T        S   SD+ R      
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811

Query: 1803 EALKQEVMSLHKQLQNAG--GKSWAPE----IATHPSGLHNQQKRL------SWDKLDHL 1850
              + +E   L ++L  +G  G    PE    +    S L    ++L      +  +L+H 
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871

Query: 1851 MNEEQQLLWQENERLQTMVQNTKA-----ELTHSREKVRQLESNLLPKHQKHLNPSGTMN 1905
               + +L+ +   + Q   ++ K      E  H   + R+  +  L K +      G ++
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE------GVID 1925

Query: 1906 PTEQEKLSLKREC-------DQFQKEQSPANRKVSQMNS----LEQELETIHLENEGLKK 1954
                EK   +R+        D+ ++E   A+ ++ ++ +    +++E E +  + E +K 
Sbjct: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985

Query: 1955 KQVKLDEQLME----MQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQ---FLQLQRQ- 2006
            +   +++QL++    +   +            DLQ  Q +A  +   EQ   F++L+++ 
Sbjct: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK-QVKALEIDVEEQVSRFIELEQEK 2044

Query: 2007 ---LLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEK 2063
               L+   + NQ L+++LE      +    ++E    V ++ + ++EQ+LK+V R     
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104

Query: 2064 VNQLKEQVSLPGHLCSPTSHSS 2085
             +Q +E   L  HL   T   S
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCS 2126



 Score =  135 bits (339), Expect = 5e-31
 Identities = 366/1905 (19%), Positives = 747/1905 (39%), Gaps = 299/1905 (15%)

Query: 322  EEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 381
            EEG E SQ ++++     + +    EL L + + L      + +A ++   +++ H    
Sbjct: 1816 EEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA-ISETSSQLEHAKVT 1874

Query: 382  VDQVVRE--------------KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRK 427
              +++RE              +E+LR  L +  + +  +A E+      I+   +     
Sbjct: 1875 QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD----- 1929

Query: 428  LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 487
             ++   ER    K ++    EQ L  A  +  ELE E ++ + E   +  +      E  
Sbjct: 1930 -EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988

Query: 488  RLENELLENAEKLA----EYENLTNKLQRNLENVLAEKFGDLDPSSAEFF-LQEERLTQM 542
             +E +LL+  EKL     E +    K++ +L+  +     D++   + F  L++E+ T++
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048

Query: 543  RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 602
              +  +Q + L+ Q+++++  L+E                           E E  +  +
Sbjct: 2049 M-DLRQQNQALEKQLEKMRKFLDEQAIDR----------------------EHERDVFQQ 2085

Query: 603  ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 662
            E   L   ++     + + E   R++  L   L++K      +  E ++S ++ Q ++++
Sbjct: 2086 EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT----DKCSELLLSKEQLQRDIQE 2141

Query: 663  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 722
            R+E E   LE ++ +L+  +         +++  H      + E   L+V+L+ E+  + 
Sbjct: 2142 RNE-EIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELS-LEVQLQAERDAID 2199

Query: 723  EKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE- 781
             K         +  +T  +   E+ RE L++     E+V+ L  +LE   +E  T L E 
Sbjct: 2200 RK---------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL 2247

Query: 782  --KHTLEKEELRK-----------------ELLEKHQRELQEGREKMETECNRRTSQIEA 822
              ++ L K+++ K                  L  K  + +QE   +++ + N + ++++ 
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID-QLNEQVTKLQQ 2306

Query: 823  QFQ-SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL 881
            Q + +   KV E     ++ LE     +++ L   Q   K   E E ++L +   + Q+ 
Sbjct: 2307 QLKITTDNKVIEEKNELIRDLE----TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362

Query: 882  LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 941
            L    ++    +  L++E + L    K  L+ ++ E+  L Q +E         +++L +
Sbjct: 2363 LANIGQKTSMNAHSLSEEADSL----KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2418

Query: 942  ------QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
                  Q+ +   S KRE    E++      S  +A   L + + E +    E   K L 
Sbjct: 2419 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478

Query: 996  MENIHKATCETADRERAEMSTEISRLQS--------------KIKEMQ-QATSPLSMLQS 1040
             +   K+  E        + T + +L+S              +IK+MQ Q      MLQ 
Sbjct: 2479 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538

Query: 1041 ---GCQVIGEEEVEG----DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE--NVKMA 1091
                 Q I EE+V         L  +Q+  +  ++N  +    +R + Q + +    ++ 
Sbjct: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2598

Query: 1092 TEISRLQQRLQKLEPGLV---MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH 1148
            ++IS L  R+ +LE  +V    S  L++   E       + E  L + + K +EG     
Sbjct: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ-KLLEG----- 2652

Query: 1149 VLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELE----NSEETRTESWELKN 1204
              ++ +  E     S     V +   ++  S      F+ELE     S  T+ E    K 
Sbjct: 2653 --NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKE 2710

Query: 1205 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEAS---PKYKLLYE-- 1259
            +  +LQE+L++   +     +    +   ++  K+KL +LE+  E      K   ++E  
Sbjct: 2711 KAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2770

Query: 1260 ----------------------------------DVSRENDCLQEELRMMETRYDEALEN 1285
                                               ++ +++C  EE+  + +++ E +E 
Sbjct: 2771 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2830

Query: 1286 NKEL-TAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQ-------GK 1337
             +EL  AE+  ++        ++ET     + Y  V++  EE   L   +Q         
Sbjct: 2831 MQELHAAEILDMES-----RHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2885

Query: 1338 IEKLQES-VVQRCDCC-----------LWEASLENLEIEPDGNILQLNQTLEECVPRVRS 1385
            I +L  S   Q  + C           ++    +  +I  +G   +     +    +++ 
Sbjct: 2886 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKG 2945

Query: 1386 VHHVIEE------CKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEE 1439
            +   +           E+ Y +G    +++V    +      I T      +  ++ L+ 
Sbjct: 2946 LLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR 3005

Query: 1440 NTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKA 1499
               +      H        EL L    LQ++   L+ER  +L   +              
Sbjct: 3006 EAEVYDSSQSHESFSDWRGELLL---ALQQVF--LEERSVLLAAFR-------------- 3046

Query: 1500 MMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEE 1559
                 ++T       V LL    +++Q++    +  +  L + D  S   L  +     +
Sbjct: 3047 ----TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS--LLSEIQALHAQ 3100

Query: 1560 MWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
            M  +  T+K+E  + +   E L+  I +   ++Q L++            Q +L  +  R
Sbjct: 3101 MNGRKITLKREQESEKPSQELLEYNIQQK--QSQMLEM------------QVELSSMKDR 3146

Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ 1679
             TE+  Q++       + E + E    K ELE         +  LEA   EVK +T    
Sbjct: 3147 ATEL--QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKT---- 3200

Query: 1680 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDK-LA 1737
             E HLL D L   ++  R  +L    +K  + L  +E+  KE+ E L   L S   + L 
Sbjct: 3201 DEVHLLNDTLASEQKKSR--ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258

Query: 1738 KSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1797
             + LLE +   + + Q+  E Q     +QL   Q +   L+  +++  +++  M S L  
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL-- 3316

Query: 1798 TQQEKEALKQEVMSLHKQLQNAGGKSWA-PEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ 1856
              +E+E        LH QLQ++ G   + P + +                 + L+ E Q+
Sbjct: 3317 -DRERE--------LHAQLQSSDGTGQSRPPLPS-----------------EDLLKELQK 3350

Query: 1857 LLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL-SLK 1915
             L +++ R+  ++  T+     S +  +Q+E +    H+K L      N   Q+K+  L+
Sbjct: 3351 QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD-RQVHRKTLQTEQEANTEGQKKMHELQ 3409

Query: 1916 RECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK-KKQVKLDEQLMEMQHLRSTAT 1974
             + +  Q++     ++V +++   Q L+ I  E +  + +++ K + + +  Q+L    T
Sbjct: 3410 SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTT 3469

Query: 1975 PSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQ---EELENRTSETNT- 2030
             S +       +LQQ+         + +L          N  L+   ++L+   S+    
Sbjct: 3470 WSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVL 3529

Query: 2031 PQGNQE--QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSL 2073
            PQ   E  Q  T  +E  I V++ +  +   LQ+   Q  E+ SL
Sbjct: 3530 PQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSL 3574



 Score =  134 bits (338), Expect = 7e-31
 Identities = 332/1570 (21%), Positives = 665/1570 (42%), Gaps = 193/1570 (12%)

Query: 345  LTELTLALEN--ELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAE-K 401
            +T L   LE   E L  KN   Q      + + +    R+ ++ +E +  + D++K    
Sbjct: 2205 ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264

Query: 402  LKSLMASEVDDHH------AAIERRNEYNLRKLDEEYKERIAALK----NELRKEREQIL 451
            +K   A    D H      A I +  E  + +L+E+  +    LK    N++ +E+ +++
Sbjct: 2265 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2324

Query: 452  QQAGKQR--LELEQEIEKAKTEENY--IRDRLALSLKENSRLENELLENAEKLAEYENLT 507
            +    Q   L  +QE  K   EE    + + +    +E + +  +   NA  L+E     
Sbjct: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE---A 2381

Query: 508  NKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEY 567
            + L+  L+ V+AEK         +     E +T M+N  +     +     EL S   E 
Sbjct: 2382 DSLKHQLDVVIAEKLA----LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2437

Query: 568  RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRD 627
             +  ++  +P +NS +  ++  S   +PE  +   E      S+E +   +  +E     
Sbjct: 2438 ESVEKIQSIP-ENSVNVAIDHLSKD-KPELEVVLTE--DALKSLENQTYFKSFEENGKGS 2493

Query: 628  ICCLR---LELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAE 684
            I  L    L+LE  V   + +L +    C K  ++M+++ + ET  L+K+I +L+ +I E
Sbjct: 2494 IINLETRLLQLESTVSAKDLELTQ----CYKQIKDMQEQGQFETEMLQKKIVNLQ-KIVE 2548

Query: 685  LQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEEKTHLQEKLRLQHEMELKARLTQAQAS 743
             +  AA++ +   EA   + +  +  Q +  E E+T++Q   +L+ + EL          
Sbjct: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED-EL---------- 2597

Query: 744  FEREREGLQSSAWTEEKVRGLTQELEQFH-----QEQLTSLVEKHTLEKEELRKELL--- 795
                  G   SA T  ++  L  ++ + H     +++   + EK+ LEKE+   EL    
Sbjct: 2598 ------GSDISALTL-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL 2650

Query: 796  ---EKHQRELQEGREKMETECNRRTSQI-----EAQFQSDCQKVTERCESALQSLE-GRY 846
               EK QRE ++ R   + E  + T+++     E+ F ++ + +  R ES     E   Y
Sbjct: 2651 EGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEAL--RAESVATKAELASY 2708

Query: 847  RQELKDLQEQQR-EEKSQWEFEKD--ELTQECAEAQELLKETLKREKTTSLVLTQEREML 903
            +++ + LQE+   +E +    +KD  ++    AEA+E L   L++E  T +  +++  M 
Sbjct: 2709 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS-ILEKEDETEVQESKKACMF 2767

Query: 904  EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQ 963
            E    +   S+  +    L+    + + ++T Q L+ +  +++    +    E  E++ Q
Sbjct: 2768 EPLPIKLSKSIASQTDGTLK----ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQ 2823

Query: 964  AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAE----MSTEIS 1019
                    ++++E+++  H  E       +L ME+ H +  ET  RE       +  E  
Sbjct: 2824 F-------TEKIEKMQELHAAE-------ILDMESRHISETETLKREHYVAVQLLKEECG 2869

Query: 1020 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1079
             L++ I+ ++          +        E+    + S   QG  L    G  + S  R 
Sbjct: 2870 TLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2929

Query: 1080 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQ-TEPFLQQNRT 1138
             E++         +I  L + +     G+ + S  + P ++   ++ +Q +EP+L++ + 
Sbjct: 2930 -EESESATDSFPKKIKGLLRAVHN--EGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKA 2986

Query: 1139 KQVEGVTRRHVLSDLE---DDEVRDLGST--------GTSSVQRQEVKIEESEASVEGFS 1187
                  + + +++ ++   + EV D   +        G   +  Q+V +EE    +  F 
Sbjct: 2987 YINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAF- 3045

Query: 1188 ELENSEETRTESWELKNQISQ-LQEQLMMLCA--DCDRASEKKQDLLFDVSVLK-----K 1239
              E +    T++  L N + Q +QEQ +   A  +C + ++++  LL ++  L      +
Sbjct: 3046 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS-LLSEIQALHAQMNGR 3104

Query: 1240 KLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAE---VFRL 1296
            K+ +        P  +LL  ++ ++   + E    + +  D A E  ++L++E   V  L
Sbjct: 3105 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3164

Query: 1297 QDELKKMEEVTETFLS--------LEKSYDEVKIENEELNVLVLRLQGKIEKLQES--VV 1346
            + EL + +   ET L         LE    EVK + +E+++L   L  + +K +E    +
Sbjct: 3165 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3224

Query: 1347 QRCDCCLWEAS------LENLEIEPDGNI---LQLN-------QTLEECVPRVRSVHHVI 1390
            ++    L  +       LE+L+   +      LQLN       Q L E   ++ S   + 
Sbjct: 3225 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3284

Query: 1391 EECKQENQYLEGNTQLL---EKVKAHEIAW-------LHGTIQ----THQERPRVQNQVI 1436
            +    E Q      Q+L   EKV+  E++        LH  +Q    T Q RP + ++ +
Sbjct: 3285 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3344

Query: 1437 LEENTTLLGFQDKHFQHQATIAEL--ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKE 1494
            L+E    L  ++KH    + I EL  E EK KL  L  + +      V +K + +  E  
Sbjct: 3345 LKELQKQL--EEKH----SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN 3398

Query: 1495 EELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRN-----EITTLNEEDSISNLK 1549
             E +  MH+LQ    ++Q+++E  R +  KL  E   L+      +   L  E+   + +
Sbjct: 3399 TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRR 3458

Query: 1550 LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQN 1609
            +   N ++   W  T   +  N  +Q+ +E   K+ +  K+   +++   T  + +    
Sbjct: 3459 ILYQNLNEPTTWSLTSD-RTRNWVLQQKIEGETKESNYAKL--IEMNGGGTGCNHELEMI 3515

Query: 1610 QEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-LKEELERCKVQSSTLVSSLEAEL 1668
            ++KLQ +  +L ++L QK  E      E  + E F  ++E ++   +Q   L      E 
Sbjct: 3516 RQKLQCVASKL-QVLPQKASE--RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEP 3572

Query: 1669 SEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEE 1728
            S V   T        LL+   E    + +  +  +  + +  V+   E++   ++  +  
Sbjct: 3573 SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM--VMKLEEQIRWYRQTGAGR 3630

Query: 1729 LNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQM 1788
             NS    L   + +E  IA+   E++ W  +  +L+  L  ++ +V  L+  ++N +L  
Sbjct: 3631 DNSSRFSLNGGANIEAIIAS---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQ 3687

Query: 1789 SRMKSDLRVT 1798
            +       VT
Sbjct: 3688 TLSPDSEHVT 3697



 Score =  120 bits (301), Expect = 1e-26
 Identities = 270/1290 (20%), Positives = 539/1290 (41%), Gaps = 209/1290 (16%)

Query: 795  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 854
            LE  + EL   + ++E E NR   ++   + ++  +  +  E+A++  +G   Q   +LQ
Sbjct: 157  LEMMESELAGKQHEIE-ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ 215

Query: 855  EQQREEKSQWEFEKDELTQECAEAQELLK-----ETLKR--EKTTSLVLTQEREMLEKTY 907
            + +R EK +   E  ELT++  + Q   +     ETL+     +T+  L Q ++ +  T+
Sbjct: 216  QARR-EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI-LTH 273

Query: 908  KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQI--------LELKSSHKRELREREE 959
            ++ L     E+  LL+D +  +     Q S L ++I         ++++S+K E++E+E 
Sbjct: 274  QQQLE----EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET 329

Query: 960  VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1019
            ++           + L    +E +++  E+  KL            TAD+   E+  +I 
Sbjct: 330  II-----------EELNTKIIEEEKKTLELKDKL-----------TTADKLLGELQEQIV 367

Query: 1020 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1079
            +   +IK M+             ++   ++ E        Q  E++ +  G V    +R 
Sbjct: 368  QKNQEIKNMK------------LELTNSKQKE-------RQSSEEIKQLMGTVEELQKRN 408

Query: 1080 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTK 1139
            H+ +  E   +       Q++L++L   L           E +G    Q +  L +    
Sbjct: 409  HKDSQFETDIVQRMEQETQRKLEQLRAEL----------DEMYGQQIVQMKQELIRQHMA 458

Query: 1140 QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES 1199
            Q+E +  RH     + +    L S    +V   ++K+     +           E   + 
Sbjct: 459  QMEEMKTRH-----KGEMENALRSYSNITVNEDQIKLMNVAIN-----------ELNIKL 502

Query: 1200 WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL-KMLERIPEASPKYKLLY 1258
             +  +Q  +L+E+L ++  +      + +DL+ ++S  ++++ +  + I E   K    +
Sbjct: 503  QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH 562

Query: 1259 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSY 1317
            + +S   D   E +   E+R +  L++  E+T    +L+   K+   V +    S E   
Sbjct: 563  KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622

Query: 1318 DEVKIE-----NEELNVLVLRLQGK----IEKLQESV----VQRCDCCLWEAS--LENLE 1362
            + ++ +      EEL+ L   L+ +    IEKL++++     Q+ D    E S  +E ++
Sbjct: 623  ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ 682

Query: 1363 IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLE----KVKAHEIAWL 1418
             E D  I + NQ + E + +++ +   +   K E   L+ N    E    + +  E   L
Sbjct: 683  FEKDNLITKQNQLILE-ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741

Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTR-----K 1473
               +Q  Q +  +  + + E+   L   Q+K  Q +A  + L+ EK  L+++ +      
Sbjct: 742  EQEVQELQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVS 798

Query: 1474 LKERVTIL--VKQKDVLSHGEKE-EELKAMMHDLQITCSEMQQKVELLR----------- 1519
             +ER+  L  +K K   S  EKE E L     DL+  C ++ +++E  R           
Sbjct: 799  QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFE 858

Query: 1520 YESEKLQQENSILRNEITTLNEEDSISNL----KLGTLNGSQEEMWQKTETVKQEN---- 1571
               ++LQ+E + L      L +  +   L    KL  LN           TVK ++    
Sbjct: 859  VNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFD 918

Query: 1572 ------AAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQR---LTE 1622
                  A   +M E ++K  +EL  K +    E  ELSQ+ S   E+L++ +     L E
Sbjct: 919  EDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNE 978

Query: 1623 MLCQKEKEPGNSALEEREQE---KFNLKEELERCKVQSSTL------VSSLEAELSEVKI 1673
             +   ++E    +L  RE E     N  E ++ C  Q S+L      ++S  AE S  K+
Sbjct: 979  EVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV 1038

Query: 1674 QTHIVQQENHLLKDEL--------EKMKQ----LHRCPDLSDFQQKISSVLSYNEKLLKE 1721
                 ++   +++D++        E+ KQ    L   P ++      ++  S N+KL KE
Sbjct: 1039 NKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKE 1098

Query: 1722 KEALSEELNSC-----VDKLAKSSLLEHRIATMKQEQKSWEHQS-ASLKSQLV-ASQEKV 1774
               L  E N         ++  S +    +  +++  ++ + ++  SLK +L+ A +EK+
Sbjct: 1099 LNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKI 1158

Query: 1775 QNLEDTVQNVNLQMSRMKSD----------LRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824
            + L+   Q   L++  MK+           L + + +K A+ +E     + L +  G+ +
Sbjct: 1159 KELQKIHQ---LELQTMKTQETGDEGKPLHLLIGKLQK-AVSEECSYFLQTLCSVLGEYY 1214

Query: 1825 APEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVR 1884
             P +      ++ + K  S D +    + E Q    E +  Q  +     ++T    K+ 
Sbjct: 1215 TPALKCE---VNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271

Query: 1885 QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELET 1944
             L++ L     +          T+  KL    E     KE++      SQM +LE +++ 
Sbjct: 1272 VLQTRLSKIWGQQ---------TDGMKLEFGEE--NLPKEETEFLSIHSQMTNLE-DIDV 1319

Query: 1945 IHLENEGLKK--KQVKLDEQLMEMQHLRST 1972
             H       +  ++ KL+EQ+ E++ L S+
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISS 1349



 Score =  115 bits (287), Expect = 6e-25
 Identities = 275/1361 (20%), Positives = 570/1361 (41%), Gaps = 240/1361 (17%)

Query: 758  EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 817
            ++K+     +L QF Q +  S  +  + ++++ RK    KH           +++CN   
Sbjct: 7    QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN--- 63

Query: 818  SQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT--QEC 875
               E    S     ++R ES +   E    + L   +    E+    E E +  T   +C
Sbjct: 64   ---EMYINS-----SQRVESTVIP-ESTIMRTLHSGEITSHEQGFSVELESEISTTADDC 114

Query: 876  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKE--------HLNSMVVERQQLLQDLED 927
            +         ++  K T+L L +E   ++ +Y E        HL  M  E      ++E+
Sbjct: 115  SSEVNGCSFVMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE 173

Query: 928  LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 987
            L    E  +     + L+     +  +++R+ ++ Q  A+ Q A            +E+ 
Sbjct: 174  LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR-----------REKD 222

Query: 988  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1047
            E M + L +         T   ++ ++  +  +    ++    +++   +LQ+  Q++  
Sbjct: 223  ETMREFLEL---------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273

Query: 1048 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1107
            ++         L++ + LLE+             Q  KE+  M  +IS LQ++++     
Sbjct: 274  QQ--------QLEEQDHLLED------------YQKKKEDFTM--QISFLQEKIK----- 306

Query: 1108 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1167
             V     D+          ++ E  +++  TK +E   +   L D      + LG     
Sbjct: 307  -VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365

Query: 1168 SVQR-QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1226
             VQ+ QE+K  + E +     E ++SEE +    +L   + +LQ++              
Sbjct: 366  IVQKNQEIKNMKLELTNSKQKERQSSEEIK----QLMGTVEELQKR-------------N 408

Query: 1227 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENN 1286
             +D  F+  ++++                 + ++  R+ + L+ EL  M  +  + ++  
Sbjct: 409  HKDSQFETDIVQR-----------------MEQETQRKLEQLRAELDEMYGQ--QIVQMK 449

Query: 1287 KELTAEVFRLQDELK-----KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQ---GKI 1338
            +EL  +     +E+K     +ME    ++ ++  + D++K+ N  +N L ++LQ    + 
Sbjct: 450  QELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509

Query: 1339 EKLQESV-VQRCDCCLWEASLENLEIE---PDGNILQLNQTLEECVPRVRSVH---HVIE 1391
            EKL+E + +   + C  +  LE+L  E       I +  QT+ E   ++   H     +E
Sbjct: 510  EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569

Query: 1392 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF 1451
            + K E      + + LE     E+              +++ +++ +E   +L   D+  
Sbjct: 570  DLKAEIVSASESRKELELKHEAEVT-----------NYKIKLEMLEKEKNAVL---DRMA 615

Query: 1452 QHQATIAELELEKTKL----QELTRKLKERVTI-----LVKQKDVLSHGEKEEELKAMMH 1502
            + Q   AELE  +T+L    +E   KLKE + I     + K KD L    K++     + 
Sbjct: 616  ESQE--AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ-----ID 668

Query: 1503 DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTLNGSQEEMW 1561
             LQ   +EM QK+E +++E + L  + + L  EI+ L + + S+ N K   +     E+ 
Sbjct: 669  GLQ---NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725

Query: 1562 QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT 1621
            ++ E ++QE    +K    L++++ EL++K + L+    ++ +K +  QEK  +L     
Sbjct: 726  KEIEILRQE----EKEKGTLEQEVQELQLKTELLE---KQMKEKENDLQEKFAQL----- 773

Query: 1622 EMLCQKEKEPGNSALEEREQEKFNLKEELE-RCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1680
                    E  NS L++   EK  L++ L+    V     +  L++  S  K +  + ++
Sbjct: 774  --------EAENSILKD---EKKTLEDMLKIHTPVSQEERLIFLDSIKS--KSKDSVWEK 820

Query: 1681 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
            E  +L +E E +KQ  +C  L++  +K  +  S+ EK  +      +E  +C+ K+ K  
Sbjct: 821  EIEILIEENEDLKQ--QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV-KDD 877

Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSD------ 1794
            L           + S   Q    KS+L A  E++      +Q +N    +MKS       
Sbjct: 878  L-----------EDSKNKQELEYKSKLKALNEELH-----LQRINPTTVKMKSSVFDEDK 921

Query: 1795 --LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1852
              +  T +  E ++++   L ++L+    K    E++   S L  Q K+   +     +N
Sbjct: 922  TFVAETLEMGEVVEKDTTELMEKLEVT--KREKLELSQRLSDLSEQLKQKHGE--ISFLN 977

Query: 1853 EEQQLLWQENERLQTMVQNTKAELTHSR-EKVRQLESNLLPKHQKHLNPSGTMNPTEQEK 1911
            EE + L QE E++    +  +  + H+R E V+  ++ +       L+   TM     E 
Sbjct: 978  EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV----SSLLDGVVTMTSRGAEG 1033

Query: 1912 LSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDE--QLMEMQHL 1969
             S+ +    F +E      K+   + +  E  T+    E  K++Q+ LD    + +   L
Sbjct: 1034 -SVSKVNKSFGEES-----KIMVEDKVSFENMTV---GEESKQEQLILDHLPSVTKESSL 1084

Query: 1970 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2029
            R+T          +L +L+ +   +  + +  ++   L+ +  ++Q ++E +EN      
Sbjct: 1085 RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ-VREYMENE----- 1138

Query: 2030 TPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
                  + L ++ EE +   E+K+K ++++ Q ++  +K Q
Sbjct: 1139 ----KDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ 1175



 Score =  113 bits (283), Expect = 2e-24
 Identities = 316/1689 (18%), Positives = 682/1689 (40%), Gaps = 287/1689 (16%)

Query: 489  LENELLENAEKLAEYENLTNKLQRNLE--NVLAEKFGDLDPSSAEFFLQEE--RLTQMRN 544
            LE+E+   A+  +   N  + + R  +  N+L E+   +D S +E   Q+    L  M +
Sbjct: 103  LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMES 162

Query: 545  EYERQCRVLQDQVDELQSELEEYRA--------------------QGRVLRLP--LKNSP 582
            E   +    Q +++EL  ELEE R                      G + +L   L+ + 
Sbjct: 163  ELAGK----QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR 218

Query: 583  SEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHY 642
             E+ E     +E      +E+   L +  +     E ++   H       L+ + ++  +
Sbjct: 219  REKDETMREFLEL-----TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273

Query: 643  EKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEI----------------AELQ 686
            ++QL+E        Q+++ + ++ +      QIS L+ +I                 E+Q
Sbjct: 274  QQQLEE--------QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325

Query: 687  GQAAVLKEAHHEATCRHEEEKKQLQVK-----LEEEKTHLQEKL--RLQHEMELKARLTQ 739
             +  +++E + +     EEEKK L++K      ++    LQE++  + Q    +K  LT 
Sbjct: 326  EKETIIEELNTKII---EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 382

Query: 740  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
            ++    +  E ++    T E+++    +  QF  + +  + ++   + E+LR EL E + 
Sbjct: 383  SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442

Query: 800  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYR---QELKDLQEQ 856
            +++ + ++++  +   +  +++ + + + +    R  S +   E + +     + +L  +
Sbjct: 443  QQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNITVNEDQIKLMNVAINELNIK 501

Query: 857  QREEKSQWEFEKDE----LTQECAEAQEL---------LKETLKREKTTSLVLTQEREML 903
             ++  SQ E  K+E    L ++CA  ++L          +E ++R + T   + ++   L
Sbjct: 502  LQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT---IAEQESKL 558

Query: 904  EKTYK-----EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRERE 958
             + +K     E L + +V   +  ++LE       T   +  + + + K++    + E +
Sbjct: 559  NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ 618

Query: 959  EVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEI 1018
            E   +   ++ L S   E  +++ D E +  ++     +N+     +  D  + EMS +I
Sbjct: 619  EAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678

Query: 1019 SRLQ-----------------SKIKEMQQA---------TSPLSMLQSGCQVIGEEEVEG 1052
              +Q                 SK+K++QQ+         T  ++ LQ   +++ +EE E 
Sbjct: 679  ETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE- 737

Query: 1053 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN-VKMATEISRLQQRLQKLEPGLVMS 1111
                  L+Q  Q L+   ++L    +  E  ++E   ++  E S L+   + LE  L + 
Sbjct: 738  ---KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794

Query: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
            + + +          E+   FL   ++K  + V  + +   +E++E           +++
Sbjct: 795  TPVSQ----------EERLIFLDSIKSKSKDSVWEKEIEILIEENE----------DLKQ 834

Query: 1172 QEVKI-EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL 1230
            Q +++ EE E     FS  E       +++E+  Q  Q +   ++   D    S+ KQ+L
Sbjct: 835  QCIQLNEEIEKQRNTFSFAE-------KNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887

Query: 1231 LFDVSVLKKKLKM------LERIPEASPKYKLLYEDVSRENDCLQEELRMME------TR 1278
             +     K KLK       L+RI   + K K    D   +   + E L M E      T 
Sbjct: 888  EY-----KSKLKALNEELHLQRINPTTVKMKSSVFD--EDKTFVAETLEMGEVVEKDTTE 940

Query: 1279 YDEALENNKELTAEVF-RLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1337
              E LE  K    E+  RL D  +++++       L +    +K E E++++    L+  
Sbjct: 941  LMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEII 1000

Query: 1338 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1397
            I   +   VQ CD          +    DG +   ++  E  V +V        +   E+
Sbjct: 1001 INHNRAENVQSCD--------TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052

Query: 1398 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV----QNQVILEENTTLLGFQ-DKHFQ 1452
            +    N  + E+ K  ++   H    T +   R     +N  + +E   L   Q D   Q
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112

Query: 1453 HQATIAELEL----EKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITC 1508
             +A    L L       +++E     K++    +K++ + +  EK +EL+  +H L++  
Sbjct: 1113 MEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQ-KIHQLELQT 1171

Query: 1509 SEMQQ------KVELLRYESEKLQQE-----------------NSILRNEITTLNEEDSI 1545
             + Q+       + LL  + +K   E                    L+ E+   ++E+S 
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1231

Query: 1546 SNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK----QISELKIKNQQLDLENTE 1601
              +        Q+  ++  +  +  +  + K+ E   K    Q    KI  QQ D    E
Sbjct: 1232 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1291

Query: 1602 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQS---- 1657
              ++N   +E         TE L    +      ++   + K +  ++LE+ K++     
Sbjct: 1292 FGEENLPKEE---------TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQE 1342

Query: 1658 -STLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDL---------SDFQ-- 1705
              +L+SSL+ +L E +      + E H L+  L+ + +    P L         SD Q  
Sbjct: 1343 LESLISSLQQQLKETE---QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399

Query: 1706 --------QKISSVLSYNEKL-LKEK----EALSEELNSCVDKLAKSSLLEHRIATMKQE 1752
                    + I   + ++ +  +KE+    + L ++    +++     ++   IA  +Q 
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459

Query: 1753 QKS-----WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQ 1807
            + S      E+ ++S ++  V  QE+    E       +++S+ +   +  +      K+
Sbjct: 1460 ELSRISGGKENTASSKQAHAVCQQEQHYFNE-------MKLSQDQIGFQTFETVDVKFKE 1512

Query: 1808 EVMSLHKQLQNAGGKSWAPEIATHPSGLHN--QQKRLSWDKLDHLMNEEQQLLWQE--NE 1863
            E   L K+L   G      EI    S  H+  + K       + + ++++  + ++  ++
Sbjct: 1513 EFKPLSKELGEHG-----KEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHD 1567

Query: 1864 RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE-CDQFQ 1922
             +     +   +L  + E++  +   L+ ++Q+H   +  +      ++  +RE  +Q Q
Sbjct: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627

Query: 1923 KEQSPANRKVSQMNSLE-----QELETIHLEN-EGLKKKQVKLDEQLMEMQHLRSTATPS 1976
            +E    NR+++Q +S++      E E + LE  E LK+  +   E+L       ST T +
Sbjct: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687

Query: 1977 PSPHAWDLQ 1985
             + +  +++
Sbjct: 1688 GNENQGEVE 1696



 Score =  100 bits (250), Expect = 1e-20
 Identities = 250/1201 (20%), Positives = 488/1201 (40%), Gaps = 210/1201 (17%)

Query: 983  DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGC 1042
            D+ERQ+ +    A     +     +D +      +  R  S  K    A   L++ QS C
Sbjct: 3    DEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC 62

Query: 1043 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQR----AHEQAVKENVKMATEISRLQ 1098
              +          ++  Q+ E  +     ++ +L      +HEQ    +V++ +EIS   
Sbjct: 63   NEM---------YINSSQRVESTVIPESTIMRTLHSGEITSHEQGF--SVELESEISTTA 111

Query: 1099 QRLQKLEPGLVMSSCLDEPAT----EFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVL 1150
                    G        +P      E FG     +E   Q + T     + E   ++H +
Sbjct: 112  DDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI 171

Query: 1151 SDL--EDDEVR-DLGSTGTSSVQRQEVKIEESEASVEGFSE-----LENSEETRTESWEL 1202
             +L  E +E+R   G+ G   +Q  E  I++ +  +   +          +ET  E  EL
Sbjct: 172  EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLEL 231

Query: 1203 KNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL----KMLERIPEASPKYKLLY 1258
              Q  +LQ Q   L A     +        D+   K+++    + LE        Y+   
Sbjct: 232  TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291

Query: 1259 EDVSRENDCLQEELRMMETRYDEALEN-NKELTAEVFRLQDELKKMEEVTETFLSLEKSY 1317
            ED + +   LQE++++ E   D+ +EN NKE       +Q++   +EE+    +  EK  
Sbjct: 292  EDFTMQISFLQEKIKVYEMEQDKKVENSNKE------EIQEKETIIEELNTKIIEEEKKT 345

Query: 1318 DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLE 1377
             E+K +    + L       + +LQE +VQ+         ++N+++E   +  +  Q+ E
Sbjct: 346  LELKDKLTTADKL-------LGELQEQIVQK------NQEIKNMKLELTNSKQKERQSSE 392

Query: 1378 ECVPRVRSVHHVIEECKQEN-----------QYLEGNTQL-LEKVKAHEIAWLHGT--IQ 1423
            E    ++ +   +EE ++ N           Q +E  TQ  LE+++A E+  ++G   +Q
Sbjct: 393  E----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA-ELDEMYGQQIVQ 447

Query: 1424 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIA----ELELEKTKLQELTRKLKERVT 1479
              QE  R     + E  T   G  +   +  + I     +++L    + EL  KL++  +
Sbjct: 448  MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507

Query: 1480 ILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1539
                QK+ L     +EEL  ++ +      +++  VE L +  E++Q+    +  + + L
Sbjct: 508  ----QKEKL-----KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558

Query: 1540 NEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1599
            NE    ++  L T+   + E+   +E+ K+     +  V N K       IK + L+ E 
Sbjct: 559  NE----AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK-------IKLEMLEKEK 607

Query: 1600 TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELE-------- 1651
              +  + +++QE   EL +  T++L               E+E   LKE+LE        
Sbjct: 608  NAVLDRMAESQEA--ELERLRTQLLFS------------HEEELSKLKEDLEIEHRINIE 653

Query: 1652 ----RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-----ELEKMKQLHRCPDLS 1702
                   +     +  L+ E+S+ KI+T   +++N + K      E+ K+K L +    S
Sbjct: 654  KLKDNLGIHYKQQIDGLQNEMSQ-KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712

Query: 1703 DFQQKISSV--LSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQ 1759
              ++    +  L    ++L+++E     L   V +L  K+ LLE +   MK+++   + +
Sbjct: 713  KSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQ---MKEKENDLQEK 769

Query: 1760 SASLKSQLVASQEKVQNLEDTV----------QNVNLQMSRMKS-------DLRVTQQEK 1802
             A L+++    +++ + LED +          + + L   + KS       ++ +  +E 
Sbjct: 770  FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829

Query: 1803 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1862
            E LKQ+ + L++++          E   +      +   +++ +L     EE   L +  
Sbjct: 830  EDLKQQCIQLNEEI----------EKQRNTFSFAEKNFEVNYQEL----QEEYACLLKVK 875

Query: 1863 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ 1922
            + L+      K EL + + K++ L   L   H + +NP+     T + K S+  E   F 
Sbjct: 876  DDLED--SKNKQELEY-KSKLKALNEEL---HLQRINPT-----TVKMKSSVFDEDKTFV 924

Query: 1923 KEQSPANRKVSQ-MNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHA 1981
             E       V +    L ++LE    E   L ++   L EQL +                
Sbjct: 925  AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKH-------------- 970

Query: 1982 WDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSE---------TNTPQ 2032
             ++  L ++   +   ++ + L+ + L+   IN +  E +++  ++         T T +
Sbjct: 971  GEISFLNEEVKSLKQEKEQVSLRCRELEI-IINHNRAENVQSCDTQVSSLLDGVVTMTSR 1029

Query: 2033 GNQEQLVTVM----EERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNS 2088
            G +  +  V     EE  I VE K+      + E+  Q  EQ+ L  HL S T  SS  +
Sbjct: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ--EQLIL-DHLPSVTKESSLRA 1086

Query: 2089 S 2089
            +
Sbjct: 1087 T 1087



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 317/1639 (19%), Positives = 657/1639 (40%), Gaps = 226/1639 (13%)

Query: 85   LSNEEHF----QEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEAR 140
            + + +HF     +P+ SLE Q +  R       + +   +E +E+F E   +E  +EE +
Sbjct: 2170 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE--ELENKNEEVQ 2227

Query: 141  PSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDL----NASQSGSSPPQDWIEEKLQEV 196
              H+   +  +   T R +E E E +L   + + L      S + S+  Q  +  K  ++
Sbjct: 2228 QLHMQL-EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2286

Query: 197  CEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG 256
             ++  +  D  LN +  V+  +Q      D +++EE  + L  D    +E     L  + 
Sbjct: 2287 IQEKEVEID-QLNEQ--VTKLQQQLKITTDNKVIEEK-NELIRDLETQIE----CLMSDQ 2338

Query: 257  KSLTPSASTPYRQLKRHLS--MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGH-ASV 313
            + +  +      QL   +    Q     G++T+ ++   S     +   LD  +    ++
Sbjct: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398

Query: 314  ERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENE-------LLVTKNSIHQA 366
            E+ ++T  EE +   + +LK  +F ++    LT+   +L+ E         + +NS++ A
Sbjct: 2399 EQQVETANEE-MTFMKNVLKETNFKMN---QLTQELFSLKRERESVEKIQSIPENSVNVA 2454

Query: 367  ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR 426
                           +D + ++K +L   L + + LKSL   E   +  + E   + ++ 
Sbjct: 2455 ---------------IDHLSKDKPELEVVLTE-DALKSL---ENQTYFKSFEENGKGSII 2495

Query: 427  KLDE---EYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSL 483
             L+    + +  ++A   EL +  +QI     + + E E   +K    +  + +++A +L
Sbjct: 2496 NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAAL 2555

Query: 484  KENSRLENELLENAEKLAEYENLTNKLQR-NLENVLAEKFGDLDPSSAEFFLQEERLTQM 542
                +LE  + E A+   + + ++++ +R N++N+   +  +L    +   L+   L   
Sbjct: 2556 VSQIQLE-AVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQ 2614

Query: 543  RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 602
              E      + ++QV+  +  + E            K     E++    G E +     +
Sbjct: 2615 VVEMHTSLILEKEQVEIAEKNVLE------------KEKKLLELQKLLEGNEKKQREKEK 2662

Query: 603  ECNPLNMSI---EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQEN 659
            + +P ++ +     EL     +     ++  LR E        + +L       +K QE 
Sbjct: 2663 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT----KAELASYKEKAEKLQEE 2718

Query: 660  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
            +  +  N T +L+K +S +++ +AE + + ++L++   E     +E KK      E    
Sbjct: 2719 LLVKETNMT-SLQKDLSQVRDHLAEAKEKLSILEK---EDETEVQESKKACM--FEPLPI 2772

Query: 720  HLQEKLRLQHEMELKARLTQAQASFEREREG----LQSSAWTEEKVRGLTQ------ELE 769
             L + +  Q +  LK   +        +  G    LQS   +EE    ++Q      +++
Sbjct: 2773 KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2832

Query: 770  QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQE-GREKMETEC--NRRTSQIEAQFQS 826
            + H  ++  +  +H  E E L++E     Q   +E G  K   +C  ++  S I     S
Sbjct: 2833 ELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHS 2892

Query: 827  DCQKVTERCESALQSLEGR----YRQELKDLQEQQREEKSQW---EFEKD------ELTQ 873
            D  +  E C S   S  G+       +  D+  + R E+S+     F K        +  
Sbjct: 2893 DAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHN 2952

Query: 874  ECAEAQELLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSM--VVERQQLLQDLEDLRN 930
            E  +   L +      +  S+    E  + E K Y   ++S+  ++ + QL ++ E + +
Sbjct: 2953 EGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYD 3011

Query: 931  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLA---SQRLERLEMEHDQERQ 987
             S++ +S  SD   EL  + ++   E   VL  A  +E  A   +  +  L     + ++
Sbjct: 3012 SSQSHES-FSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE 3070

Query: 988  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP-LSMLQSGCQVIG 1046
            + +    AME + KA   +   E   +  +++  +  +K  Q++  P   +L+   Q   
Sbjct: 3071 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ 3130

Query: 1047 EEEVEGDGALSLLQ-QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE 1105
             + +E    LS ++ +  +L E+     + +     +  +  +++ T +    + L++LE
Sbjct: 3131 SQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE 3190

Query: 1106 P-GLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL-----SDLEDDEVR 1159
               L +    DE       +T        +Q ++++++    +         + + +E+ 
Sbjct: 3191 AFRLEVKDKTDE--VHLLNDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELE 3243

Query: 1160 DLGSTGTSSVQR----------QEVKIEESEASVEGFSELENSEETRTESWELKNQISQL 1209
            DL  +  S  QR          Q+  + ES+  +E    L +++ +  +   L+ Q+   
Sbjct: 3244 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLE 3303

Query: 1210 QEQLMM--LCADCDRASEKKQDL------------LFDVSVLKKKLKMLERIPEASPKYK 1255
             E++ +  + +  DR  E    L            L    +LK+  K LE   + S   +
Sbjct: 3304 SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEE--KHSRIVE 3361

Query: 1256 LLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEK 1315
            LL E    + D LQ   +M + R      + K L  E     +  KKM E+      L++
Sbjct: 3362 LLNETEKYKLDSLQTRQQMEKDRQ----VHRKTLQTEQEANTEGQKKMHELQSKVEDLQR 3417

Query: 1316 SYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
              +E + +  +L++   RLQG +++ Q+  ++R      E   E+  I        LN+ 
Sbjct: 3418 QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER------EEKRESRRI----LYQNLNEP 3467

Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKA------HEIAWLHGTIQTHQERP 1429
                +   R+ + V+++ K E +  E N   L ++        HE+  +   +Q    + 
Sbjct: 3468 TTWSLTSDRTRNWVLQQ-KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3526

Query: 1430 RVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLS 1489
            +V  Q   E         +     Q  I E+ L+   LQ+LT +  E  +++       S
Sbjct: 3527 QVLPQKASERLQFETADDEDFIWVQENIDEIILQ---LQKLTGQQGEEPSLV---SPSTS 3580

Query: 1490 HGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE------- 1542
             G   E L             ++Q  EL  + S+ L +E + LRN +  L E+       
Sbjct: 3581 CGSLTERL-------------LRQNAELTGHISQ-LTEEKNDLRNMVMKLEEQIRWYRQT 3626

Query: 1543 ----DSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
                D+ S   L        +  S++E+W +      E   +QK ++  + ++ +LK   
Sbjct: 3627 GAGRDNSSRFSLNGGANIEAIIASEKEVWNR------EKLTLQKSLKRAEAEVYKLK--- 3677

Query: 1593 QQLDLENTELSQKNSQNQE 1611
               +L N  L Q  S + E
Sbjct: 3678 --AELRNDSLLQTLSPDSE 3694


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score =  153 bits (387), Expect = 1e-36
 Identities = 411/2099 (19%), Positives = 801/2099 (38%), Gaps = 421/2099 (20%)

Query: 329  QEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVRE 388
            +E+ KA +        L    + LENEL + + S         + EI  L ++++Q  RE
Sbjct: 71   EEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRE 130

Query: 389  KEKLRSDLDKAEKLKSLMA---SEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 445
             E +  +L+K +K+   +A    E ++ ++ + R N+  L+K +E+  + I   + ++  
Sbjct: 131  LEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENK-RLKKKNEQLCQDIIDYQKQIDS 189

Query: 446  EREQILQQAG----------KQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLE 495
            ++E +L + G          K+  EL Q +++ +T      +++ +  +E  +   E ++
Sbjct: 190  QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE-ANEKIEVQNQEMRKNLEESVQ 248

Query: 496  NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQM---RNEYERQCRV 552
              EK+ +  N    +    +NV+ +    L   +  + LQ + LT +   +NE +    V
Sbjct: 249  EMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQLQVQELTDLLKSKNEEDDPIMV 304

Query: 553  -LQDQVDELQ-------SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 604
             +  +V+E +        E+ EY+     LR  LKN+  +  ++N   ++        + 
Sbjct: 305  AVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQI 364

Query: 605  NPLNMSIEA--------ELVIEQMK-------------EQHHRDICCLRLELEDKVRHYE 643
              L   +E           +IE +K             +Q H  I      L++K +  E
Sbjct: 365  KMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAE 424

Query: 644  KQ-------------------------------LDETVVSCKKAQENMKQRHEN------ 666
            +                                L++ VV  K  +  +K R         
Sbjct: 425  RTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTK 484

Query: 667  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEAT-CRHEEEKKQLQVKLEEEKTHLQEKL 725
            E + LE +ISD  +E   L+ +  +  +   + T  R+ +  KQ Q + E +    + + 
Sbjct: 485  EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIES 544

Query: 726  RLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ---FHQEQLTSLVEK 782
              +  ++LK ++ Q     ER +    S   TE+    LT+ + Q     + +L  L  K
Sbjct: 545  LEEERLDLKKKIRQMAQ--ERGKRSATSGLTTEDL--NLTENISQGDRISERKLDLLSLK 600

Query: 783  HTLE----KEELRKELLEKHQRELQEGREKMETECNR------RTSQIEAQFQSDCQKVT 832
            +  E     E L +EL+EK +R+L+  R  +    N+         Q+E   +   Q + 
Sbjct: 601  NMSEAQSKNEFLSRELIEK-ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK 659

Query: 833  ER-----------------CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
            E                   E  + ++E +  + + D     + +  Q     +EL QE 
Sbjct: 660  EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719

Query: 876  AEA--------QELLKETLK---REKTTSLVLTQEREML--------------------- 903
             E+        Q+L K  LK    EK TSL+   E   +                     
Sbjct: 720  RESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINS 779

Query: 904  EKTYKEHLNSMVVERQQLLQDLEDLRN-------VSETQQSLLSDQILELKSSHK----- 951
            +  Y  HL   +  +++ L++LED          V   QQSLL  + L  K + K     
Sbjct: 780  QNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKT 839

Query: 952  --RELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATC-ETAD 1008
               E R+ E+ + Q     +  +  L  L+M+ D+     M K+LA EN  K T  +  +
Sbjct: 840  IKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDE-----MKKILA-ENSRKITVLQVNE 893

Query: 1009 RERAEMSTEISRLQSKIKEM--QQATSPLSMLQSGCQVIG----------------EEEV 1050
            +      T +  L+ ++++   +Q    LSM    C+ IG                ++ V
Sbjct: 894  KSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953

Query: 1051 EGDGALS------------------LLQQGEQLLEE---------------------NGD 1071
            +   +LS                  +LQ+   L++                      N +
Sbjct: 954  DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKE 1013

Query: 1072 VLLSLQRAH--EQAVKENVKMATEISRLQQR----------LQKLEPGLVMSSCLDEPAT 1119
            + ++ ++ H  EQA ++  K+  E S  + +          + K    L M    +    
Sbjct: 1014 LEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRA 1073

Query: 1120 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLE----------DDEVRDLGSTGTSSV 1169
            E      E     L+Q   +  E  T+   L+ +            DE+ D  S   S  
Sbjct: 1074 EHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133

Query: 1170 QRQ---EVKIEESEASVEGFSELENSEETRTESWELKNQISQLQ----EQLMMLCADCDR 1222
             RQ   E++  E E  VE  S+L    +      E+ N   Q +    E L M   D   
Sbjct: 1134 DRQRILELEKNEMELKVE-VSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192

Query: 1223 ASEKKQDLL----FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1278
             S++K  +      +VS+   +   L ++   + K + +     R    L E+ + +   
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252

Query: 1279 YDEALENNKELTAEVFRLQDE------LKKMEEVTETFLSLEKSYDEVKI---------E 1323
              E     K L   +  L+ +      L + E+ ++T + L+   D++KI         E
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQE 1310

Query: 1324 NEELNVLVLRLQGKIEKLQESVVQRCDC------CLWEASLENLEIEPDGNILQLNQTLE 1377
            +  +    L ++ K++ L+E +    D         W   +E L ++     L+LN+ L 
Sbjct: 1311 HRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE----LKLNRELV 1366

Query: 1378 ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHE---IAWLHGTIQTHQERPRVQNQ 1434
            +    ++ ++++I E ++    LE   +++++ K HE   +AW    +   +     Q  
Sbjct: 1367 KDKEEIKYLNNIISEYERTISSLE--EEIVQQNKFHEERQMAWDQREVDLER-----QLD 1419

Query: 1435 VILEENTTLLGFQDKHFQHQATIAELELE-KTKLQELTRKLKERVTILVKQKDVL-SHGE 1492
            +   +   +L    K  +   +I +  L    +L+   RK+KE + I+++ +    S  E
Sbjct: 1420 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEE 1479

Query: 1493 KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG- 1551
            K +E ++ +   +       + +  LR       +   ++        E  S   LK+  
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539

Query: 1552 -TLNGSQEEMWQKTETVKQENAAVQKMVEN----LKKQISELKIKNQQLDLENTELSQKN 1606
             T+   Q  + QK E +K+    ++K  E     +KK   +L I + +L+L+      K 
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKF 1599

Query: 1607 SQNQE-----------------KLQELNQRLTEM------LCQKEKEPGNSALEEREQEK 1643
             Q                    +L E+ Q + E       L  K K+       +RE  +
Sbjct: 1600 KQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITE 1659

Query: 1644 FNLKEELERCKVQ----SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH-RC 1698
              +KE  E  K+Q        V  ++AE+ ++K      Q+E+  LK EL+  K+ + R 
Sbjct: 1660 LKVKE-FENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRA 1718

Query: 1699 P--DLSDFQQKISSVLSYNEK-----------LLKEKEALSEE--LNSCVDK---LAKSS 1740
            P   + +  +++ S L+  EK           L  E  A +EE  +++   K   L    
Sbjct: 1719 PTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778

Query: 1741 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1800
            +++     +K + +        LK  L  S+ +  +L D + ++N ++ + +       +
Sbjct: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838

Query: 1801 EKEALKQEVMSLHKQLQN-AGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN------- 1852
            EKE + QE   L +Q++    G    P      S +   Q+++   KL++ +        
Sbjct: 1839 EKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK--KLENQLEGKVEEVD 1896

Query: 1853 ---------EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1903
                     +E+ + W+E ++ Q  ++         R K+++ E  +    ++       
Sbjct: 1897 LKPMKEKNAKEELIRWEEGKKWQAKIEGI-------RNKLKEKEGEVFTLTKQLNTLKDL 1949

Query: 1904 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL 1963
                ++EKL+L+R+     K       +V  + +LE E E      E LKK+ + L+  +
Sbjct: 1950 FAKADKEKLTLQRKL----KTTGMTVDQVLGIRALESEKEL-----EELKKRNLDLENDI 2000

Query: 1964 MEMQ--------------HLRSTATPSPSPHAWDLQLLQQ----------QACPMVPREQ 1999
            + M+              HL++        HA + Q  +           ++     REQ
Sbjct: 2001 LYMRAHQALPRDSVVEDLHLQNRYL-QEKLHALEKQFSKDTYSKPSISGIESDDHCQREQ 2059

Query: 2000 FLQLQRQLLQAERINQHLQEELENR-TSETNTPQGNQEQLVTVMEERMIEVEQKLKLVK 2057
             LQ +   L +E I    Q E  N+          + +++   +++   EV++KL  V+
Sbjct: 2060 ELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVR 2118



 Score =  149 bits (375), Expect = 4e-35
 Identities = 301/1518 (19%), Positives = 645/1518 (42%), Gaps = 195/1518 (12%)

Query: 310  HASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALA 369
            H   E I    Q E I    EI K    +++      E  L  E+ +   K SI  + + 
Sbjct: 995  HLECENISLKEQVESINKELEITKEKLHTIEQAWE-QETKLGNESSMDKAKKSITNSDIV 1053

Query: 370  SFKAEIRHL-------LERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNE 422
            S   +I  L        +R +   +  E LR+ L + E+       E++   A + + N 
Sbjct: 1054 SISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF----ELETKFAELTKIN- 1108

Query: 423  YNLRKLDEEYKERIA--ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLA 480
             + +K+++  ++ +A    K     +R++IL+   K  +EL+ E+ K +   +  R ++ 
Sbjct: 1109 LDAQKVEQMLRDELADSVSKAVSDADRQRILELE-KNEMELKVEVSKLREISDIARRQVE 1167

Query: 481  LSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLT 540
            +   +    + E+     +L +Y+  ++  +++L   L +    L  S A    + E +T
Sbjct: 1168 ILNAQQQSRDKEVESLRMQLLDYQAQSD--EKSLIAKLHQHNVSLQLSEATALGKLESIT 1225

Query: 541  QMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLG 600
                + E     L+ ++DE +  L   R +GR     L+ +  + +     G  P     
Sbjct: 1226 SKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT-IQSLRRQFSGALPLAQQE 1284

Query: 601  SEECNPLNMSIEAELVIEQMK--EQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
                  + +  +   ++++MK  +Q HR++    LE+E K++  E +L  T+   K AQ+
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE-ELISTLKDTKGAQK 1343

Query: 659  NMKQRHENETHTLEK------------QISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 706
             +    + E   L++            +I  L N I+E +   + L+E   +    HEE 
Sbjct: 1344 VINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEER 1403

Query: 707  KKQLQVKLEEEKTHLQEKL----RLQHEMELKARL----------------TQAQASFER 746
                Q+  ++ +  L+ +L    R Q+E+   A+                  Q + +  +
Sbjct: 1404 ----QMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 1459

Query: 747  EREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL-------LEKHQ 799
             +E ++    T    + L ++L++  +E    L E++ L ++++  EL        E+ +
Sbjct: 1460 IKENIRIILETRATCKSLEEKLKE--KESALRLAEQNILSRDKVINELRLRLPATAEREK 1517

Query: 800  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
               + GR++ME + +  T +I  Q  ++ Q    + E  L+    +Y++ L+  +E+QRE
Sbjct: 1518 LIAELGRKEMEPK-SHHTLKIAHQTIANMQARLNQKEEVLK----KYQRLLEKAREEQRE 1572

Query: 860  EKSQWEFE------------KDELTQECAEAQELLKETLKREKTTS-LVLTQEREMLEKT 906
               + E +               L +    A +L+K++     T    +   E E     
Sbjct: 1573 IVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAE 1632

Query: 907  YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH-------KRELREREE 959
              + L+S++V+ +++ QDLE  R ++E +     +  L+L+ +H       K E+ + + 
Sbjct: 1633 QDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKY 1692

Query: 960  VLCQAGASEQLASQRLERLEMEHDQER--------QEMMSKLLAMENIHKATCETADRER 1011
            +L Q+    Q     L+  +  + +          + + S+L   E   KA        R
Sbjct: 1693 LLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELR 1752

Query: 1012 AEMS--------TEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGE 1063
            AEM+        +  S+ ++ +   Q        L++  + + E  ++   AL   +  E
Sbjct: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812

Query: 1064 QLLEEN----GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPAT 1119
              L +N     + L   Q+A+ + ++E  ++  E   L++++++L  GL       +P T
Sbjct: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQ-----GKPLT 1867

Query: 1120 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDL------GSTGTSSVQRQE 1173
            +   +  E+ +  +++    Q+EG      L  +++   ++       G    + ++   
Sbjct: 1868 DNKQSLIEELQRKVKKLEN-QLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIR 1926

Query: 1174 VKIEESEASVEGFSELENS---------EETRTESWELKNQISQLQEQLMMLCADCDRAS 1224
             K++E E  V   ++  N+         +E  T   +LK     + + L +   + ++  
Sbjct: 1927 NKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKEL 1986

Query: 1225 E--KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEA 1282
            E  KK++L  +  +L        R  +A P+  ++ ED+  +N  LQE+L  +E ++ + 
Sbjct: 1987 EELKKRNLDLENDILYM------RAHQALPRDSVV-EDLHLQNRYLQEKLHALEKQFSKD 2039

Query: 1283 LENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ 1342
              +   ++       D  ++ +E+ +  L L     E+K + E+ N  + RL+ ++  L+
Sbjct: 2040 TYSKPSISG--IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLK 2097

Query: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYL-- 1400
            E     C+    E +    ++       +  +T+ E    +  +  V+E+ ++EN+ L  
Sbjct: 2098 EM----CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKK 2153

Query: 1401 --------------EGNTQL---LEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1443
                          + N +L   LEK+KAH    L   +  H E      + I+ EN  L
Sbjct: 2154 ASGILTSEKMANIEQENEKLKAELEKLKAH----LGHQLSMHYESKTKGTEKIIAENERL 2209

Query: 1444 LGFQDKHFQHQATIAE-LELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMH 1502
                 K  + +   AE L + K  L+ L     E++T+ +++      G++ +  ++   
Sbjct: 2210 R----KELKKETDAAEKLRIAKNNLEILN----EKMTVQLEET-----GKRLQFAESRGP 2256

Query: 1503 DLQITCSEMQQKVELLR-YESEKLQQENSILRNE--ITTLNEEDSISNLKLGTLNGSQEE 1559
             L+   S+  + + + R YE++  + E  I +    IT L +    +  +   +N   E+
Sbjct: 2257 QLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNED 2316

Query: 1560 MWQKTETVKQ--ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL-QEL 1616
            + Q+ + +K   E A  +   + LK+++  L++ N QLD E  EL  +   N+++   E 
Sbjct: 2317 LEQQIKILKHVPEGAETE---QGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373

Query: 1617 NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTH 1676
                 + L +K K+   + L+  + EK +LKEE+++ K +      S   E+ ++K    
Sbjct: 2374 TIPDADQLKEKIKDL-ETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYK 2432

Query: 1677 IVQQENHLLKDELEKMKQ 1694
               ++N LL+++++K+ +
Sbjct: 2433 EEVKKNILLEEKVKKLSE 2450



 Score =  148 bits (373), Expect = 6e-35
 Identities = 333/1715 (19%), Positives = 699/1715 (40%), Gaps = 262/1715 (15%)

Query: 441  NELRKERE----------QILQQAGKQRLELE-QEIEKAKTEENYIRDRLALSLKENSRL 489
            NEL+ E++          Q L +   Q +EL  +E+EKA  E+    ++L   +    +L
Sbjct: 38   NELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVM---KL 94

Query: 490  ENELLENAEKLA---EYENLTNKLQRNLENVLAEKFGDLDPSSAEF----------FLQE 536
            ENEL E A++ A   +   L N++ + LE  L +K  +L+    E            L+ 
Sbjct: 95   ENEL-EMAQQSAGGRDTRFLRNEICQ-LEKQLEQKDRELEDMEKELEKEKKVNEQLALRN 152

Query: 537  ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
            E      ++  R+ + L+ + ++L  ++ +Y+ Q    +  L +   E+ +  S   +  
Sbjct: 153  EEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKN 212

Query: 597  HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
            + L  +  + +    EA   IE   ++       +R  LE+ V+  EK  DE        
Sbjct: 213  YEL-IQYLDEIQTLTEANEKIEVQNQE-------MRKNLEESVQEMEKMTDEY-----NR 259

Query: 657  QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHE------ATCRHEEEKKQL 710
             + +  + +N    L+K+    + ++ EL     +LK  + E      A     EE K +
Sbjct: 260  MKAIVHQTDNVIDQLKKENDHYQLQVQELTD---LLKSKNEEDDPIMVAVNAKVEEWKLI 316

Query: 711  QVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 770
                ++E    Q+ L    E    A+L   +++    ++G+Q     + +++ LT+++EQ
Sbjct: 317  LSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER---DSQIKMLTEQVEQ 373

Query: 771  FHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQK 830
            + +E     +EK+T   E+L+ EL           R K  +  +++T           ++
Sbjct: 374  YTKE-----MEKNTCIIEDLKNELQ----------RNKGASTLSQQTHMKIQSTLDILKE 418

Query: 831  VTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREK 890
             T+  E   +  E   R++ K+L E  +  K   ++E      E A  +      +K  K
Sbjct: 419  KTKEAERTAELAEADAREKDKELVEALKRLK---DYESGVYGLEDAVVE------IKNCK 469

Query: 891  TTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSH 950
                +  +E E+L K     +N + ++    L + E LR     +   + D      S H
Sbjct: 470  NQIKIRDREIEILTK----EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKH 525

Query: 951  KRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKL--LAMENIHKATCETAD 1008
             ++ + R E         Q+  + +E LE    +ER ++  K+  +A E   ++      
Sbjct: 526  LKQQQYRAE--------NQILLKEIESLE----EERLDLKKKIRQMAQERGKRSATSGLT 573

Query: 1009 RERAEMSTEISRLQSKIKEMQQ---ATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQL 1065
             E   ++  IS+   +I E +    +   +S  QS  + +  E +E           E+ 
Sbjct: 574  TEDLNLTENISQ-GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK----------ERD 622

Query: 1066 LEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS---SCLDEPATEFF 1122
            LE +  V+   Q   ++ V+EN ++   +  + Q +++++    +    + L  P+ E  
Sbjct: 623  LERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERL 682

Query: 1123 GNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEAS 1182
             N  E          +K  EG+    +    + D++     TG +   RQE++  ES   
Sbjct: 683  VNAIE----------SKNAEGIFDASLHLKAQVDQL-----TGRNEELRQELR--ESRKE 725

Query: 1183 VEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRA-----------SEKKQDLL 1231
               +S+       + +  E +  + +  E   ++    D             + + + L+
Sbjct: 726  AINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785

Query: 1232 FDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTA 1291
              +  L+ K K L+ + ++   Y   +  +  +   L          Y E L   +    
Sbjct: 786  HLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL----------YKEYLSEKETWKT 835

Query: 1292 EVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDC 1351
            E   +++E +K+E+  +         D +K++  E N L+  LQ   +++++ + +    
Sbjct: 836  ESKTIKEEKRKLEDQVQQ--------DAIKVK--EYNNLLNALQMDSDEMKKILAEN--- 882

Query: 1352 CLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVK 1411
                  +  L++     I Q   TL E   ++R      E  KQ+N+ L    ++ EK+ 
Sbjct: 883  ---SRKITVLQVNEKSLIRQYT-TLVELERQLRK-----ENEKQKNELLSMEAEVCEKI- 932

Query: 1412 AHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELT 1471
                    G +Q  +E    +   +            K   +  +++ELEL   +  ELT
Sbjct: 933  --------GCLQRFKEMAIFKIAAL-----------QKVVDNSVSLSELELANKQYNELT 973

Query: 1472 RKLKE---RVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKVELLRYESE 1523
             K ++   +  +LV++   L H E E     E+++++  +L+IT  ++        +  E
Sbjct: 974  AKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKL--------HTIE 1025

Query: 1524 KLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1583
            +  ++ + L NE +    + SI+N  + +++     +  K    +Q     QKM E+L+ 
Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085

Query: 1584 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1643
             + +++ +N +L+ +  EL++ N   Q+  Q L   L + + +   +     + E E+ +
Sbjct: 1086 SLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNE 1145

Query: 1644 FNLKEELERCKVQSSTLVSSLEAELSEV-KIQTHIVQQENHLLKDELEKMK-QLHRCPDL 1701
              LK E+ + +            E+S++ + Q  I+  +      E+E ++ QL      
Sbjct: 1146 MELKVEVSKLR------------EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQ 1193

Query: 1702 SDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSA 1761
            SD +  I+ +  +N  L   +     +L S   KL K      R+     EQK  E + A
Sbjct: 1194 SDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRL-----EQKLDEKEQA 1248

Query: 1762 SLKSQLVASQEKVQNLEDTVQNVNLQMS---------RMKSDLRVTQQEKEALKQEVMSL 1812
               ++L   + + ++L  T+Q++  Q S         +    +   Q +K  + QE+ + 
Sbjct: 1249 LYYARL-EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNS 1307

Query: 1813 HKQLQNAGGKS--------WAPEIATHPSGLHNQQKRLSWD-KLDHLMNEEQQL---LWQ 1860
             ++ +N   K+           E+ +        QK ++W  K++ L  +E +L   L +
Sbjct: 1308 QQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK 1367

Query: 1861 ENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQ 1920
            + E ++  + N  +E   +   +  LE  ++ +++ H          +Q ++ L+R+ D 
Sbjct: 1368 DKEEIK-YLNNIISEYERT---ISSLEEEIVQQNKFH---EERQMAWDQREVDLERQLDI 1420

Query: 1921 FQKEQSPANRKVSQMNSLEQEL--ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS 1978
            F ++Q+       +       +   ++ L N+ L+    K+ E +  +   R+T      
Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQ-LEIALRKIKENIRIILETRATCKSLEE 1479

Query: 1979 PHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQ--E 2036
                    L+     ++ R++ +   R  L A    + L  EL  +  E  +    +   
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539

Query: 2037 QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
            Q +  M+ R+ + E+ LK  +RLL++   + +E V
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIV 1574



 Score =  139 bits (351), Expect = 2e-32
 Identities = 412/2027 (20%), Positives = 815/2027 (40%), Gaps = 328/2027 (16%)

Query: 332  LKALDFSLDGNINLTELTLALENELLVT----KNSIHQAALASFKAEIRHLLERVDQVVR 387
            LK  DF LD N  L E  + LE + ++     +NS H      ++AE + LL+ ++ +  
Sbjct: 491  LKISDF-LDENEALRE-RVGLEPKTMIDLTEFRNSKHLKQ-QQYRAENQILLKEIESLEE 547

Query: 388  E----KEKLRSDLDKAEKLKSLMASEVDDHHAA--IERRNEYNLRKLDEEYKERIAALKN 441
            E    K+K+R    +  K  +      +D +    I + +  + RKLD      + +LKN
Sbjct: 548  ERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLD------LLSLKN 601

Query: 442  ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 501
                E +   +   ++ +E E+++E+++T     +++L   ++EN +LE  + E  + + 
Sbjct: 602  --MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK 659

Query: 502  EYEN-----------LTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 550
            E +            +   L+R +  + ++    +  +S     Q ++LT    E  ++ 
Sbjct: 660  EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719

Query: 551  RVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANS---GGIEPEHGLGSEECNPL 607
            R  + +      +L   +A  ++  L  + S   + E ++    GI+   G+     + +
Sbjct: 720  RESRKEAINYSQQLA--KANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASII 777

Query: 608  NMSIEAELVIEQMKEQHHRDICCLRLELEDK------VRHYEKQLDETVVSCKKAQENMK 661
            N   E  + + Q  E   + +  L   LED       +RH +  L +  +S K+  +   
Sbjct: 778  NSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTES 837

Query: 662  QRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT-- 719
            +  + E   LE Q+     ++ E       L+    E      E  +++ V    EK+  
Sbjct: 838  KTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897

Query: 720  -------HLQEKLRLQHE------MELKARLTQAQASFERERE----------------- 749
                    L+ +LR ++E      + ++A + +     +R +E                 
Sbjct: 898  RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957

Query: 750  GLQSSAWTEEKVRGLTQELEQFHQE-----QLTSLVEKHTLEKEELRKELLEKHQRELQE 804
             L       ++   LT +     Q+     Q TS +E    E   L KE +E   +EL+ 
Sbjct: 958  SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISL-KEQVESINKELEI 1016

Query: 805  GREKMETECNRRTSQIEAQFQSDCQKVTERC-ESALQSLEGRYRQ-ELKDLQEQQREEKS 862
             +EK+ T       + +   +S   K  +    S + S+  +    E+K+L E+QR E  
Sbjct: 1017 TKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAE-- 1074

Query: 863  QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLL 922
                        C +  E L+ +LK+ +  +  L  E +  E T K +L++  VE Q L 
Sbjct: 1075 -----------HCQKMYEHLRTSLKQMEERNFEL--ETKFAELT-KINLDAQKVE-QMLR 1119

Query: 923  QDLEDLRNVSETQQSLLSDQILELKS---------SHKREL----REREEVLC--QAGAS 967
             +L D  +VS+        +ILEL+          S  RE+    R + E+L   Q    
Sbjct: 1120 DELAD--SVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRD 1177

Query: 968  EQLASQRLERLEMEHDQERQEMMSKLLAME---NIHKATC----ETADRERAEMSTEISR 1020
            +++ S R++ L+ +   + + +++KL        + +AT     E+   +  +M     R
Sbjct: 1178 KEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLR 1237

Query: 1021 LQSKIKEMQQAT-----SPLSMLQSGCQVIGEEEVEGDGALSLLQQ---GEQLLEENGDV 1072
            L+ K+ E +QA         +  +   Q I     +  GAL L QQ    + +++   D 
Sbjct: 1238 LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDK 1297

Query: 1073 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1132
            L  +Q   + + +E+  M  +   ++ +L+ LE   ++S+  D    +   N   + E  
Sbjct: 1298 LKIMQEM-KNSQQEHRNMENKTLEMELKLKGLEE--LISTLKDTKGAQKVINWHMKIEEL 1354

Query: 1133 LQQNRTKQVEGVTRRH---VLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1189
              Q      E V  +     L+++  +  R + S     VQ+ +   E   A  +   +L
Sbjct: 1355 RLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDL 1414

Query: 1190 ENS--------EETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL 1241
            E           E    + + +     + +  + L    + A  K ++ +  +   +   
Sbjct: 1415 ERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATC 1474

Query: 1242 KMLE-RIPEASPKYKLLYEDVSRENDCLQE-ELRMMETRYDEALE---NNKELTAE---- 1292
            K LE ++ E     +L  +++   +  + E  LR+  T   E L      KE+  +    
Sbjct: 1475 KSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHT 1534

Query: 1293 -------VFRLQDELKKMEEVTETFLSL-EKSYDE----VKIENEELNVLVLRLQGKIEK 1340
                   +  +Q  L + EEV + +  L EK+ +E    VK   E+L++L  RL    E 
Sbjct: 1535 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL----EL 1590

Query: 1341 LQESVVQRCDCCLWEASLEN-LEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQY 1399
              +S + +     W+   ++   +  + + ++L +  +    +  S+  ++ + K+ +Q 
Sbjct: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQD 1650

Query: 1400 LEGNTQLLE-KVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
            LE   ++ E KVK  E   L        E  +V+ +V  E+   LL    K  + Q   +
Sbjct: 1651 LERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV--EDLKYLLDQSQK--ESQCLKS 1706

Query: 1459 ELELEK--------TKLQELTRKLKERVTILVKQKDVLSHG--EKEEELKAMMHDLQITC 1508
            EL+ +K        T ++ L  +LK ++ +  KQ+  LS    E   E+ A   +  I+ 
Sbjct: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISA 1766

Query: 1509 SE-------MQQKVEL----LRYESEKLQQENSILRNEI-TTLNEEDSISNLKLGTLNGS 1556
            +        +QQ V+     L+ + E L +    L+  + T+ N E+S+++  L  LN  
Sbjct: 1767 TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTD-NLNDLNNE 1825

Query: 1557 QEEMWQKTETVKQENAAVQKMVENLKKQISELK--------IKNQQLDLENTELSQKNSQ 1608
             ++  +    + +E   + +  + LK+QI  L           N+Q  +E  +   K  +
Sbjct: 1826 LQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885

Query: 1609 NQ--EKLQELNQRLTEMLCQKEK--------------EPGNSALEEREQEKFNLKEELER 1652
            NQ   K++E++ +  +    KE+              E   + L+E+E E F L ++L  
Sbjct: 1886 NQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNT 1945

Query: 1653 CK---VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-ELEKMKQLHRCPDLSDFQQKI 1708
             K    ++     +L+ +L    +    V     L  + ELE++K+ +   +      + 
Sbjct: 1946 LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005

Query: 1709 SSVL---SYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKS 1765
               L   S  E L  +   L E+L++   + +K +  +  I+ ++ +      Q    K 
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ-KE 2064

Query: 1766 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWA 1825
             L  S E ++ L+  ++  N  + R+K+ +R  ++  E LK+E   + ++L +  G   +
Sbjct: 2065 NLKLSSENIE-LKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS 2123

Query: 1826 ----PEIATHPSGLHN-----QQKRLSWDKLDHLMNEEQQL-LWQENERLQTMVQNTKAE 1875
                PE+      +       Q++     K   ++  E+   + QENE+L+  ++  KA 
Sbjct: 2124 GKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAH 2183

Query: 1876 LTH--------------------------------SREKVRQLESNL----------LPK 1893
            L H                                + EK+R  ++NL          L +
Sbjct: 2184 LGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEE 2243

Query: 1894 HQKHLNPSGTMNP---------------TEQEKLSLKR-ECDQFQKEQS----------- 1926
              K L  + +  P               T   +  LK  E D  +K QS           
Sbjct: 2244 TGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEA 2303

Query: 1927 -PANRKVSQMN-SLEQELETIHLENEGLKKKQ-VKLDEQLMEMQHLRSTATPSPSPHAWD 1983
                +KV++ N  LEQ+++ +    EG + +Q +K + Q++ + + +     +   H  +
Sbjct: 2304 TEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIE 2363

Query: 1984 LQLLQQQACPMVP-----REQFLQLQRQLLQAERINQHLQEELENRTSE-TNTPQGNQEQ 2037
                Q  A   +P     +E+   L+ QL  ++   QHL+EE++    E  N      E+
Sbjct: 2364 ANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEE 2423

Query: 2038 LVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHS 2084
            +  +      EV++ +     LL+EKV +L EQ+ +   L SP + S
Sbjct: 2424 IEDLKYNYKEEVKKNI-----LLEEKVKKLSEQLGV--ELTSPVAAS 2463



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 226/1145 (19%), Positives = 463/1145 (40%), Gaps = 218/1145 (19%)

Query: 313  VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 372
            +ER LD +  +      EIL A     +   ++ + +L L N+L        + AL   K
Sbjct: 1414 LERQLDIFDRQ----QNEILNAAQKFEEATGSIPDPSLPLPNQL--------EIALRKIK 1461

Query: 373  AEIRHLLER------VDQVVREKE------------------KLRSDLDKAEKLKSLMAS 408
              IR +LE       +++ ++EKE                  +LR  L    + + L+A 
Sbjct: 1462 ENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIA- 1520

Query: 409  EVDDHHAAIERRNEYNLRKLDEEYKERIAAL--KNELRKEREQILQQAGKQRLELEQEIE 466
              +     +E ++ + L+   +      A L  K E+ K+ +++L++A +++ E+   ++
Sbjct: 1521 --ELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREI---VK 1575

Query: 467  KAKTEENYIRDRLAL----SLKENSRLENELLENAE----------KLAEYENLTNKLQR 512
            K + + + +  RL L    SL +  +   +L++ +           +LAE E    +   
Sbjct: 1576 KHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDD 1635

Query: 513  NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQ----DQVDELQSELEEYR 568
            +L ++L +    L   S +   Q E       E+E     LQ    D+V ++++E+E+ +
Sbjct: 1636 SLSSLLVK----LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLK 1691

Query: 569  A---QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHH 625
                Q +     LK+    + EANS          +     L   ++++L +   KE+  
Sbjct: 1692 YLLDQSQKESQCLKSELQAQKEANSRA-------PTTTMRNLVERLKSQLAL---KEKQQ 1741

Query: 626  RDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAEL 685
            + +    LEL  ++    ++   +  S K+A  N++Q  +  T  L+ Q+ DL   + +L
Sbjct: 1742 KALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKL 1801

Query: 686  QGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFE 745
            +      K   +  T    +   +LQ K +     L+EK  +  E +      + +   +
Sbjct: 1802 KEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEND------ELKRQIK 1855

Query: 746  REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 805
            R   GLQ    T+ K                 SL+E                   ELQ  
Sbjct: 1856 RLTSGLQGKPLTDNK----------------QSLIE-------------------ELQRK 1880

Query: 806  REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG-RYRQELKDLQEQQREEKSQW 864
             +K+E +   +  +++ +      K     E  ++  EG +++ +++ ++ + +E+    
Sbjct: 1881 VKKLENQLEGKVEEVDLK----PMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK---- 1932

Query: 865  EFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQD 924
            E E   LT++       LK+   +     L L ++ +    T  + L    +E ++ L++
Sbjct: 1933 EGEVFTLTKQL----NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEE 1988

Query: 925  LE----DLRN---VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER 977
            L+    DL N        Q+L  D ++E      R L+E+   L +  + +  +   +  
Sbjct: 1989 LKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISG 2048

Query: 978  LEM-EHDQERQEMMSK--LLAMENIH----------------------KATCETADRERA 1012
            +E  +H Q  QE+  +   L+ ENI                       K  CE   +E+A
Sbjct: 2049 IESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKA 2108

Query: 1013 EMSTEISRLQSK------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL------SLLQ 1060
            E+  ++  ++        I E+++    +  +    Q   E+  +  G L      ++ Q
Sbjct: 2109 EVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168

Query: 1061 QGEQLLEE----NGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDE 1116
            + E+L  E       +   L   +E   K   K+  E  RL++ L+K           + 
Sbjct: 2169 ENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-----------ET 2217

Query: 1117 PATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV---QRQE 1173
             A E     A+     L +  T Q+E   +R   ++    ++    S    S+   +  E
Sbjct: 2218 DAAEKL-RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE 2276

Query: 1174 VKIEESEASV----EGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQD 1229
             K++E E  +    +  ++L+   +  TE  +  N+ ++  EQ + +       +E +Q 
Sbjct: 2277 TKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG 2336

Query: 1230 LLFDVSVL--------KKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDE 1281
            L  ++ VL        K+K +++ +I EA+ K +   E    + D L+E+++ +ET+   
Sbjct: 2337 LKRELQVLRLANHQLDKEKAELIHQI-EAN-KDQSGAESTIPDADQLKEKIKDLETQL-- 2392

Query: 1282 ALENNKELTAEVFRLQDELKKMEEVTETF-LSLEKSYDEVKIENEELNVLVLRLQGKIEK 1340
                 K    E   L++E+KK+++  E F  S  +  +++K   +E     + L+ K++K
Sbjct: 2393 -----KMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447

Query: 1341 LQESV 1345
            L E +
Sbjct: 2448 LSEQL 2452


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  153 bits (387), Expect = 1e-36
 Identities = 224/1134 (19%), Positives = 499/1134 (44%), Gaps = 120/1134 (10%)

Query: 760  KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
            KV+ L Q   Q  + Q     ++  L+K + R++  E   +EL++   ++  E N    Q
Sbjct: 847  KVKPLLQVTRQEEEMQ----AKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 820  IEAQFQ--SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAE 877
            ++A+ +  ++ +++  R  +  Q LE     E++   E++ +   Q + E+ ++ Q+  +
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 878  AQELLKE------TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-RN 930
             +E L+E       L+ EK T+    ++ E       +  N +  ER+ L + + DL  N
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 931  VSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMM 990
            ++E ++   +  + +LK+ H+  + E E  L      E+ + Q LE+L+ + + +  +  
Sbjct: 1022 LAEEEEK--AKNLTKLKNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 991  SKLLAME-NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEE 1049
             ++  ++  I +   + A +E  E+   ++RL  +I +   A   +  L+     I + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEE-ELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQ 1131

Query: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
             + D   +   + E+   + G+ L +L+   E  +          ++ + R ++ +   V
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA------TQQELRAKREQEVTV 1185

Query: 1110 MSSCLDEPATEFFGNTAEQTEPFLQ--QNRTKQVEGVTRRHVLSD-----LEDDEVRDLG 1162
            +   LDE          E  +   Q  +  T+Q+E   R     D     LE +     G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 1163 STGTSSVQRQEV--KIEESEASVEGF-SELENSEETRTESWELKNQISQLQEQLMMLCAD 1219
                    +QEV  K ++ EA V+   S+  + E  R    EL +++ +LQ ++  +   
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHKLQNEVESVTGM 1302

Query: 1220 CDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRY 1279
             + A  K   L  DV+ L  +L+  + + +   + KL   +VS +   L+EE   ++ + 
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL---NVSTKLRQLEEERNSLQDQL 1359

Query: 1280 DEALENNKELTAEV----FRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLV---L 1332
            DE +E  + L   +     +L D  KK+++   T  +LE+     + E E L        
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419

Query: 1333 RLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV--HHVI 1390
                K+EK +  + Q  D  +    L+N + +   N+ +  +  ++ +   +++   +  
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLV--VDLDN-QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1391 EECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDK- 1449
            E  + E +  E  T+ L   +A E A     ++  +E  R  N+++  E   L+  +D  
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEA-----LEAKEELERT-NKMLKAEMEDLVSSKDDV 1530

Query: 1450 -------HFQHQATIAELELEKTKLQEL------TRKLKERVTILVK------QKDVLSH 1490
                       +A   ++E  KT+L+EL      T   K R+ + ++      ++D+ + 
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 1491 GEKEEE----LKAMMHDLQITCSEMQQKVELLRYESEKLQQE--NSILRNEITTLNEEDS 1544
             E+ EE    L+  +H+ +    + +++  L     +KL+ +  +  L+ +      E++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 1545 ISNLK------------LGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKN 1592
            I  L+            L     S++E++   +  +++  +++  +  L++ ++  +   
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 1593 QQLDLENTELSQK---NSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEE 1649
            +Q DLE  EL+++   +   +  LQ+  +RL   + Q E+E     LEE +     + + 
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-----LEEEQGNMEAMSDR 1765

Query: 1650 LERCKVQSSTLVSSLEAELSEVKIQTHIVQQ---ENHLLKDELEKMKQLHRC---PDLSD 1703
            + +   Q+  L + L  E S  +      QQ   +N  L+ +L +M+   +      ++ 
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 1704 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL 1763
             + KI+ +    E+  +EK+A ++ L    DK  K  LL+  +   ++  + ++ Q+   
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQ--VEDERKMAEQYKEQAEKG 1882

Query: 1764 KSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1817
             +++   + +++  E+  Q +N    +++ +L    +  EA+ +EV +L  +L+
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  147 bits (371), Expect = 1e-34
 Identities = 251/1125 (22%), Positives = 481/1125 (42%), Gaps = 189/1125 (16%)

Query: 351  ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
            A E+EL  TK    +A     + E++ L ++  Q+  EK  L+  L    +L +  A E+
Sbjct: 863  AKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEM 916

Query: 411  DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQIL--------QQAGKQRL 459
                AA ++  E  L +++   EE ++R   L+ E +K  +Q+L        ++A +Q+L
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976

Query: 460  ELEQEIEKAKTEENYIRDRLALSLKENSRL--ENELLEN---------AEKLAEYENLTN 508
            +LE+   +AK ++  + D + +   +N++L  E +LLE          AE+  + +NLT 
Sbjct: 977  QLEKVTAEAKIKK--LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT- 1033

Query: 509  KLQRNLENVLAE---KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSEL- 564
            KL+   E++++E   +    + S  E    + +L    +++  Q   LQ Q+ EL+ +L 
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 565  -EEYRAQGRVLRL----PLKNSPSEEVEANSGGI-EPEHGLGSEEC-------------- 604
             +E   Q  + RL      KN+  +++    G I + +  L SE                
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 605  ------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQE 658
                    L  ++++    ++++ +  +++  L+  L+++ R +E Q+ E      +A E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 659  NMKQRHE---NETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
             + ++ E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQ 1269

Query: 716  E----------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQS 753
            E           +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q 
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 754  SAWTEEKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
                E + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 813  CNRRTSQIEA------QFQSDCQKVTERCE------SALQSLEGRYRQELKDL---QEQQ 857
                 S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 858  RE-----EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLV 895
            R+     EK Q +F++             DE  +  AEA+E  KET    L R    +L 
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALE 1504

Query: 896  LTQEREMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKR 952
              +E E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED---- 1560

Query: 953  ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERA 1012
            EL+  E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620

Query: 1013 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1072
              +    +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D 
Sbjct: 1621 LAAAAKKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDF 1664

Query: 1073 LLSLQRAHEQ------AVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
               L+ A           KEN K A     L+  L +L+  L  +    + A       A
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKA---KSLEADLMQLQEDLAAAERARKQADLEKEELA 1721

Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGF 1186
            E+    L      Q E       ++ LE++   + G+    S + ++   +  + S E  
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1187 SELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1246
            +E   +++  +   +L+ Q  +L+ +L       +     K      ++ L+ K+  LE 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH------EMEGAVKSKFKSTIAALEAKIAQLEE 1835

Query: 1247 IPEASPKYK------LLYEDVSRENDCLQ-EELRMMETRYDEALENNKELTAEVFRLQDE 1299
              E   + K      L  +D   +   LQ E+ R M  +Y E  E      A V +L+ +
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG---NARVKQLKRQ 1892

Query: 1300 LKKMEEVTETF----LSLEKSYDEVKIENE----ELNVLVLRLQG 1336
            L++ EE ++        L++  DE    NE    E+N L  +L+G
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937



 Score =  145 bits (367), Expect = 3e-34
 Identities = 246/1108 (22%), Positives = 460/1108 (41%), Gaps = 172/1108 (15%)

Query: 321  QEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLE 380
            +++  EN  + L+     L    NL +  L  E EL      + +  LA+ K E+  +L 
Sbjct: 874  RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM-RVRLAAKKQELEEILH 932

Query: 381  RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIER----RNEYNLRKLDEEYK--- 433
             ++  + E+E     L +AE+ K  MA ++ D    +E     R +  L K+  E K   
Sbjct: 933  EMEARLEEEEDRGQQL-QAERKK--MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989

Query: 434  --ERIAAL---KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 488
              + I  +    N+L KER+ + ++       L +E EKAK          ++     S 
Sbjct: 990  LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI----SE 1045

Query: 489  LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 548
            LE  L +  +   E E L  KL+ +  +   E+  DL    AE  +Q   L +   E + 
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQ---LAKKEEELQA 1101

Query: 549  QCRVLQDQVDELQSELEEYRA-QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 607
                L D++ +  + L++ R  +G +    L+     E  A +   + +  LG EE   L
Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLG-EELEAL 1158

Query: 608  NMSIEAEL----VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 663
               +E  L      ++++ +  +++  L+  L+++ R +E Q+ E      +A E + ++
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 664  HENETHT---LEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE---- 716
             E        L+K    L+ E A+L G+  VL +A  E     E +KK+L+ +++E    
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV----EHKKKKLEAQVQELQSK 1274

Query: 717  ------EKTHLQEKL-RLQHEME-LKARLTQAQ----------ASFEREREGLQSSAWTE 758
                   +  L +K+ +LQ+E+E +   L +A+          AS   + +  Q     E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334

Query: 759  EKVR-GLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 817
             + +  ++ +L Q  +E+  SL ++  L++E   K+ LE+H   L       + +     
Sbjct: 1335 TRQKLNVSTKLRQLEEER-NSLQDQ--LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 818  SQIEA------QFQSDCQKVTERCESA------LQSLEGRYRQELKDLQ---EQQRE--- 859
            S +EA      +FQ + + +T++ E        L+  + R +QEL DL    + QR+   
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 860  --EKSQWEFEK-------------DELTQECAEAQELLKET----LKREKTTSLVLTQER 900
              EK Q +F++             DE  +  AEA+E  KET    L R    +L   +E 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE--KETKALSLARALEEALEAKEEL 1509

Query: 901  EMLEKTYKEHLNSMVVERQQL---LQDLEDLRNVSETQQSLLSDQILELKSSHKRELRER 957
            E   K  K  +  +V  +  +   + +LE  +   ETQ   +  Q+ EL+     EL+  
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED----ELQAT 1565

Query: 958  EEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTE 1017
            E+   +   + Q    + ER     D++ +E   +L    + ++   E   ++RA  +  
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625

Query: 1018 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQ 1077
              +L+  +K+++        LQ+   + G EE         ++Q  +L  +  D    L+
Sbjct: 1626 KKKLEGDLKDLE--------LQADSAIKGREEA--------IKQLRKLQAQMKDFQRELE 1669

Query: 1078 RAHEQ------AVKENVKMA----TEISRLQQRLQKLEPG-----LVMSSCLDEPATEFF 1122
             A           KEN K A     ++ +LQ+ L   E       L      +E A+   
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 1123 GNTAEQTEPFLQQNRTKQVE-----------GVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
            G  A Q E    + R  Q+E            ++ R   +  + +++ +  +T  S+ Q+
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 1172 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL 1231
             E   ++ E   +      +  E   +S + K+ I+ L+ ++  L    ++ + +KQ   
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848

Query: 1232 FDVSVLKKKLK-----------MLERIPEASPK-------YKLLYEDVSRENDCLQEELR 1273
              +    KKLK           M E+  E + K        K   E+   E+  +    R
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908

Query: 1274 MMETRYDEALENNKELTAEVFRLQDELK 1301
             ++   DEA E+N+ +  EV  L+ +L+
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  145 bits (366), Expect = 4e-34
 Identities = 245/1200 (20%), Positives = 509/1200 (42%), Gaps = 169/1200 (14%)

Query: 433  KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
            +E + A ++EL+K +E+  Q+A  +  ELEQ+  +   E+N ++++L    +  +  E  
Sbjct: 858  EEEMQAKEDELQKTKER-QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 493  LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 552
             +  A K  E E + ++++  LE                   +E+R  Q++ E ++  + 
Sbjct: 917  RVRLAAKKQELEEILHEMEARLEE------------------EEDRGQQLQAERKKMAQQ 958

Query: 553  LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 612
            + D    L+ +LEE  A  + L+L    +     EA    +E E  +  ++ N L+    
Sbjct: 959  MLD----LEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQNNKLSKE-- 1007

Query: 613  AELVIEQMKEQHHRDICCLRLELEDKVRH-------YEKQLDETVVSCKKAQ------EN 659
                  ++ E+   D+     E E+K ++       +E  + E  V  KK +      E 
Sbjct: 1008 -----RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 660  MKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKT 719
            +K++ E +     +QI+DL+ +IAEL+ Q A  +E    A  R ++E  Q        K 
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ--------KN 1114

Query: 720  HLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSL 779
            +  +K+R     EL+  ++  Q   + ER     +   E++ R L +ELE    E     
Sbjct: 1115 NALKKIR-----ELEGHISDLQEDLDSERAARNKA---EKQKRDLGEELEALKTEL---- 1162

Query: 780  VEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESAL 839
              + TL+    ++EL  K ++E+   ++ ++ E     +Q++   Q   Q V E  E   
Sbjct: 1163 --EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL- 1219

Query: 840  QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 899
                    ++ K  +    + K   E E  +L  E     +  +E   ++K       Q 
Sbjct: 1220 --------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE---AQV 1268

Query: 900  REMLEK-----TYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 954
            +E+  K       +  LN  V + Q  ++ +  + N +E +   L+  +  L S    +L
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS----QL 1324

Query: 955  REREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEM 1014
            ++ +E+L +    +   S +L +LE E +  + ++  ++ A +N+ +            +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER-----------HI 1373

Query: 1015 STEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1074
            ST   +L    K++Q   S +  L+ G +   ++E+E     +L QQ     EE      
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRF-QKEIE-----NLTQQ----YEEKAAAYD 1423

Query: 1075 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1134
             L++   +  +E   +  ++   +Q +  LE        L           A++ +    
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 1135 QNRTKQVEGVTRRHVLSD-LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
            + R K+ + ++    L + LE  E  +L  T        E  +   +   +   ELE S+
Sbjct: 1484 EAREKETKALSLARALEEALEAKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 1194 ET-RTESWELKNQISQLQEQLM-----MLCADCDRASEKKQ---DLLFDVSVLKKKLKML 1244
                T+  E+K Q+ +L+++L       L  + +  + K Q   DL       ++K + L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601

Query: 1245 ERIPEASPKYKLLYEDVSRENDC-------LQEELRMMETRYDEALENNKELTAEVFRLQ 1297
            +R      +Y+   ED  ++          L+ +L+ +E + D A++  +E   ++ +LQ
Sbjct: 1602 QR---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658

Query: 1298 DELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEAS 1357
             ++K  +   E       S DE+    +E       L+  + +LQE +    +    +A 
Sbjct: 1659 AQMKDFQRELE---DARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQAD 1714

Query: 1358 LENLEI-EPDGNILQLNQTLEECVPRVRS-VHHVIEECKQENQYLEGNTQLLEKVK---- 1411
            LE  E+ E   + L     L++   R+ + +  + EE ++E   +E  +  + K      
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 1412 --AHEIAWLHGTIQTHQ---ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTK 1466
              ++E+A    T Q ++   ++   QN+ +  +   + G     F  ++TIA LE +  +
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF--KSTIAALEAKIAQ 1832

Query: 1467 LQE-LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKL 1525
            L+E + ++ +E      KQ    S  +K+++LK ++  LQ+   + ++  E  + ++EK 
Sbjct: 1833 LEEQVEQEARE------KQAATKSLKQKDKKLKEIL--LQV--EDERKMAEQYKEQAEKG 1882

Query: 1526 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
                  L+ ++    EE          +N ++ ++ ++ +   + N A+ + V  LK ++
Sbjct: 1883 NARVKQLKRQLEEAEEESQ-------RINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  139 bits (349), Expect = 4e-32
 Identities = 242/1180 (20%), Positives = 492/1180 (41%), Gaps = 146/1180 (12%)

Query: 560  LQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQ 619
            LQ   +E   Q +   L       ++ E     +E +H   +EE N L   ++AE  +  
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 620  MKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLK 679
              E+    +   + ELE+ +   E +L+E        +E+  Q+ + E   + +Q+ DL+
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEE--------EEDRGQQLQAERKKMAQQMLDLE 963

Query: 680  NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQ 739
             ++ E +     L+     A  + ++ + ++ V ++++   L ++ +L     L+ R++ 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKL-----LEERISD 1017

Query: 740  AQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQ 799
               +   E          EEK + LT +L+  H+  ++ L  +  L+KEE  ++ LEK +
Sbjct: 1018 LTTNLAEE----------EEKAKNLT-KLKNKHESMISELEVR--LKKEEKSRQELEKLK 1064

Query: 800  RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE 859
            R+L+        +     +QI A+ +    K  E  ++AL  L+    Q+   L++ +  
Sbjct: 1065 RKLEGDASDFHEQIADLQAQI-AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123

Query: 860  EKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVE-- 917
            E    + ++D  ++  A  +    E  KR+      L +E E L+   ++ L+S   +  
Sbjct: 1124 EGHISDLQEDLDSERAARNK---AEKQKRD------LGEELEALKTELEDTLDSTATQQE 1174

Query: 918  -RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE 976
             R +  Q++  L+   + +      Q+ E++  H + + E  E L Q   ++    +  +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234

Query: 977  RLEMEH-------------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQS 1023
             LE E+              QE +    KL A     ++ C   +R RAE++ ++ +LQ+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294

Query: 1024 K---------------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEE 1068
            +               IK  +   S  S LQ   +++ EE  +     + L+Q E+  E 
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE--ER 1352

Query: 1069 NGDVLLSLQRAHEQAVKENVK--MATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
            N    L  Q   E   K+N++  ++T   +L    +KL+        L+E    F     
Sbjct: 1353 NS---LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTG--TSSVQRQEVKIEESEASVE 1184
              T+ + ++         T+  +  +L DD V DL +     S++++++ K ++  A  +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 1185 GFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKML 1244
              S     E  R E+     +  + + + + L    + A E K++L     +LK +++ L
Sbjct: 1469 NISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 1245 ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME 1304
                  S K     +DV +    L++  R +ET+ +E     +EL  E+   +D   ++E
Sbjct: 1524 -----VSSK-----DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 1305 EVTETFL-SLEKSYDEVKIENEELNVLVLRLQGKIE-KLQESVVQRCDCCL----WEASL 1358
               +      E+       +NEE    + R   + E +L++   QR          E  L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 1359 ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWL 1418
            ++LE++ D  I    +  EE + ++R +   +++ ++E          LE  +A     +
Sbjct: 1634 KDLELQADSAI----KGREEAIKQLRKLQAQMKDFQRE----------LEDARASRDE-I 1678

Query: 1419 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRKLKER 1477
              T + ++++ +            L+  Q+     +    + +LEK +L +EL   L  R
Sbjct: 1679 FATAKENEKKAK-------SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731

Query: 1478 VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEIT 1537
              +           +++  L+A +  L+    E Q  +E +     K  Q+   L NE+ 
Sbjct: 1732 NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1538 TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDL 1597
            T       +      L    +E+  K    + E A   K     K  I+ L+ K  QL+ 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLH--EMEGAVKSK----FKSTIAALEAKIAQLEE 1835

Query: 1598 ENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN-----LKEELER 1652
            +  + +++     + L++ +++L E+L Q E E   +   + + EK N     LK +LE 
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 1653 CKVQSSTLVSS---LEAELSEVKIQTHIVQQENHLLKDEL 1689
             + +S  + ++   L+ EL E       + +E + LK +L
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  110 bits (276), Expect = 1e-23
 Identities = 221/1124 (19%), Positives = 459/1124 (40%), Gaps = 145/1124 (12%)

Query: 1020 RLQSKIKEMQQATSPLSMLQSG---CQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSL 1076
            RL +K+K + Q T     +Q+     Q   E + + +  L  L+Q    L E  ++L   
Sbjct: 843  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 1077 QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1136
             +A  +   E  +M   ++  +Q L+++     M + L+E                 +++
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHE--MEARLEE-----------------EED 943

Query: 1137 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1196
            R +Q++   ++     L+ +E  +        +Q ++V  E     +E    + + +  +
Sbjct: 944  RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003

Query: 1197 TESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL 1256
                 L  +   L+E++  L  +     EK ++L         KLK       +  + +L
Sbjct: 1004 -----LSKERKLLEERISDLTTNLAEEEEKAKNLT--------KLKNKHESMISELEVRL 1050

Query: 1257 LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS 1316
              E+ SR+   L++  R +E    +  E   +L A++  L+ +L K EE  E   +L + 
Sbjct: 1051 KKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE--ELQAALARL 1106

Query: 1317 YDEVKIENEELNVLVLRLQGKIEKLQESV-VQRCDCCLWEASLENLEIEPDGNILQLNQT 1375
             DE+  +N  L   +  L+G I  LQE +  +R      E    +L  E +    +L  T
Sbjct: 1107 DDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165

Query: 1376 LEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQV 1435
            L+    +           K+E +       L E+ ++HE            +  R ++  
Sbjct: 1166 LDSTATQQEL------RAKREQEVTVLKKALDEETRSHE---------AQVQEMRQKHAQ 1210

Query: 1436 ILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE 1495
             +EE T  L       Q +   A L+  K  L++    L   + +L + K  + H  K++
Sbjct: 1211 AVEELTEQLE------QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH--KKK 1262

Query: 1496 ELKAMMHDLQITCSEMQQKVELLRYESEKLQQE--------NSILRNEITTLNEEDSISN 1547
            +L+A + +LQ  CS+ ++    L  +  KLQ E        N      I    +  S+S+
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 1548 LKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNS 1607
                T    QEE  QK   V  +   +++   +L+ Q+ E     Q L+   + L+ + S
Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 1608 QNQEKLQELN-------------QRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 1654
             +++KLQ+               Q+  E L Q+ +E   +A ++ E+ K  L++EL+   
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQELDDLV 1440

Query: 1655 VQSST---LVSSLEAELSEVKIQTHIVQQENHLLK--DELEKMKQLHRCPDLS--DFQQK 1707
            V       LVS+LE +  + K    + +++N   K  DE ++ +   R  +       + 
Sbjct: 1441 VDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 1708 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQL 1767
            +   L   E+L +  + L  E+    D ++    +   +  +++ +++ E Q   +K+QL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555

Query: 1768 VASQEKVQNLEDTVQNVNLQMSRMKS----DLRVTQQEKEALKQEVM-SLHK-QLQNAGG 1821
               ++++Q  ED    + + M  +K     DL+   ++ E  ++++   LH+ + +    
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615

Query: 1822 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR- 1880
            +      A     L    K L       +   E+ +  ++  +LQ  +++ + EL  +R 
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARA 1673

Query: 1881 -------------EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC-------DQ 1920
                         +K + LE++L+   +            + EK  L  E        + 
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733

Query: 1921 FQKEQSPANRKVSQMNS-LEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1979
             Q E+     +++Q+   LE+E   +   ++ ++K   + ++   E+   RSTA  + S 
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 1980 HAWDLQLLQQQACPMVPREQFLQ------LQRQLLQAERINQHLQEELENRTSETNTPQG 2033
                 Q L++Q   +  +   ++       +  +   E     L+E++E    E      
Sbjct: 1794 R----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849

Query: 2034 NQEQLVTVMEERMIEVEQKLKLVKRLLQE------KVNQLKEQV 2071
            + +Q    ++E +++VE + K+ ++  ++      +V QLK Q+
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893



 Score =  106 bits (264), Expect = 3e-22
 Identities = 210/977 (21%), Positives = 408/977 (41%), Gaps = 126/977 (12%)

Query: 1169 VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQ 1228
            V RQE +++  E  ++   E +   E   +  EL+ + SQL E+  +L          ++
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKAENELK--ELEQKHSQLTEEKNLL----------QE 901

Query: 1229 DLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKE 1288
             L  +  +  +  +M  R+  A+ K +L  E++  E +   EE    E R  +     K+
Sbjct: 902  QLQAETELYAEAEEMRVRL--AAKKQEL--EEILHEMEARLEE---EEDRGQQLQAERKK 954

Query: 1289 LTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQG-KIEKLQESVVQ 1347
            +  ++  L+++L++ EE     L LEK   E KI+  E  +LV+  Q  K+ K ++ + +
Sbjct: 955  MAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 1348 RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL 1407
            R        + E    E   N+ +L    E           +I E +   +  E + Q L
Sbjct: 1014 RISDLTTNLAEEE---EKAKNLTKLKNKHES----------MISELEVRLKKEEKSRQEL 1060

Query: 1408 EKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-- 1465
            EK+K      L G      E+       I E    L     K  + QA +A L+ E    
Sbjct: 1061 EKLKRK----LEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEIAQK 1113

Query: 1466 -----KLQELTRKLKERVTILVKQKDVLSHGEKE-----EELKAMMHDLQITCSEMQQKV 1515
                 K++EL   + +    L  ++   +  EK+     EEL+A+  +L+ T      + 
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173

Query: 1516 ELLRYESEKLQQENSILRNEIT--TLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAA 1573
            EL      K +QE ++L+  +   T + E  +  ++      + EE+ ++ E  K+  A 
Sbjct: 1174 EL----RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKAN 1228

Query: 1574 VQKMVENLKKQISEL--------------KIKNQQLDLENTELSQKNSQNQEKLQELNQR 1619
            + K  + L+K+ ++L              + K ++L+ +  EL  K S  +    ELN +
Sbjct: 1229 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288

Query: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE---VKIQTH 1676
            + ++  Q E E     L E E +   L +++     Q       L+ E  +   V  +  
Sbjct: 1289 VHKL--QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346

Query: 1677 IVQQENHLLKDELEKMKQLHRCPD---------LSDFQQKISSVLSYNEKLLKEKEALSE 1727
             +++E + L+D+L++  +  +  +         LSD ++K+    S  E L + K+   +
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 1728 ELNSCVDKLAKSSLLEHRIATMKQE-QKSWEHQSASLKSQ--LVASQEKVQNLEDTVQNV 1784
            E+ +   +  + +    ++   K   Q+  +     L +Q  LV++ EK Q   D +   
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 1785 NLQMSRMKSDLRVTQQEKEALKQEV--MSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRL 1842
               +S   +D R  + E EA ++E   +SL + L+ A       E+      L  + + L
Sbjct: 1467 EKNISSKYADER-DRAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDL 1523

Query: 1843 SWDKLD-----HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP-KHQK 1896
               K D     H + + ++ L  + E ++T ++  + EL  + +   +LE N+   K Q 
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 1897 HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK----VSQMNSLEQELETIHLENEGL 1952
              +        E+++  L+R+  +++ E     ++     +    LE +L+ + L+ +  
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643

Query: 1953 KK------KQV-KLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQR 2005
             K      KQ+ KL  Q+ + Q     A  S        +  +++A  +      +QLQ 
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQE 1701

Query: 2006 QLLQAERIN-------QHLQEELENRTSETNTPQGNQEQL---VTVMEERMIEVEQKLKL 2055
             L  AER         + L EEL +  S  N  Q  + +L   +  +EE + E +  ++ 
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 2056 VKRLLQEKVNQLKEQVS 2072
            +   ++ K  Q  EQ+S
Sbjct: 1762 MSDRVR-KATQQAEQLS 1777


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,428,771
Number of Sequences: 37866
Number of extensions: 3608181
Number of successful extensions: 49992
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 496
Number of HSP's successfully gapped in prelim test: 1534
Number of HSP's that attempted gapping in prelim test: 16160
Number of HSP's gapped (non-prelim): 14520
length of query: 2096
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1978
effective length of database: 13,779,330
effective search space: 27255514740
effective search space used: 27255514740
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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