Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 33695109
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33695109 Rab9 effector protein with kelch motifs [Homo
sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens] 794 0.0
gi|98986457 host cell factor 1 [Homo sapiens] 96 5e-20
gi|7019405 host cell factor C2 [Homo sapiens] 94 2e-19
gi|7657301 kelch domain containing 2 [Homo sapiens] 90 3e-18
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ... 81 1e-15
gi|16945972 kelch domain containing 3 [Homo sapiens] 80 3e-15
gi|21314675 kelch domain containing 4 [Homo sapiens] 77 2e-14
gi|44917619 kelch domain containing 10 [Homo sapiens] 72 6e-13
gi|11056006 kelch-like 12 [Homo sapiens] 62 6e-10
gi|26190616 kelch domain containing 1 [Homo sapiens] 61 1e-09
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens] 57 2e-08
gi|62955044 F-box protein 42 [Homo sapiens] 55 8e-08
gi|11545731 gigaxonin [Homo sapiens] 55 1e-07
gi|158508542 kelch-like 33 [Homo sapiens] 54 2e-07
gi|24432026 kelch-like [Homo sapiens] 54 2e-07
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 54 3e-07
gi|148664209 kelch-like 10 [Homo sapiens] 53 5e-07
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 53 5e-07
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 52 1e-06
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 52 1e-06
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 52 1e-06
gi|55741643 kelch-like 14 [Homo sapiens] 51 1e-06
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 50 4e-06
gi|45643138 kelch-like 13 [Homo sapiens] 49 7e-06
gi|24308181 kelch-like 9 [Homo sapiens] 49 7e-06
gi|34101268 kelch-like 8 [Homo sapiens] 48 1e-05
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 48 2e-05
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 48 2e-05
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 47 2e-05
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 47 2e-05
>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
Length = 372
Score = 794 bits (2051), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MKQLPVLEPGDKPRKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNR 60
MKQLPVLEPGDKPRKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNR
Sbjct: 1 MKQLPVLEPGDKPRKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNR 60
Query: 61 SFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLN 120
SFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLN
Sbjct: 61 SFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLN 120
Query: 121 PETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTW 180
PETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTW
Sbjct: 121 PETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTW 180
Query: 181 SQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAP 240
SQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAP
Sbjct: 181 SQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAP 240
Query: 241 AGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCI 300
AGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCI
Sbjct: 241 AGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCI 300
Query: 301 IPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGGMNTEG 360
IPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGGMNTEG
Sbjct: 301 IPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGGMNTEG 360
Query: 361 EIYDDCIVTVVD 372
EIYDDCIVTVVD
Sbjct: 361 EIYDDCIVTVVD 372
>gi|98986457 host cell factor 1 [Homo sapiens]
Length = 2035
Score = 95.9 bits (237), Expect = 5e-20
Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 31/265 (11%)
Query: 50 VFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQ 109
+ + GG N ++H + +QW + +G +P A++ C R+ VFGG +
Sbjct: 45 IVVFGGGNEG-IVDELHVYNTATNQWFIPAVRGDIPP-GCAAYGFVCDGTRLLVFGGMVE 102
Query: 110 SGN-RNCLQVLNPETRTWT-----TPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQ 163
G N L L W TP+ PPP PR H+ S +GN+ Y+FGG ++
Sbjct: 103 YGKYSNDLYELQASRWEWKRLKAKTPK-NGPPPCPRLGHSFSL-VGNKCYLFGGLANDSE 160
Query: 164 PVQDT------KLHVFD----ANTLTWSQPETLGNPPSPRHGHVMVA------AGTKLFI 207
++ L++ + + + W P T G P PR H V +KL I
Sbjct: 161 DPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVI 220
Query: 208 HGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGAL 267
+GG++G R DL +DI + W K + +G AP + HSA +G +Y+FGG P
Sbjct: 221 YGGMSGCRL-GDLWTLDIDTLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMD 279
Query: 268 DTMYQYHTEEQHWT----LLKFDTL 288
D H +E T L DT+
Sbjct: 280 DVKVATHEKEWKCTNTLACLNLDTM 304
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/246 (30%), Positives = 114/246 (46%), Gaps = 45/246 (18%)
Query: 25 GDSPCARVGHSCSYLPPVGNAKRGKVFIVGGA---------NPNRSFSDVHTMDL----G 71
G PC R+GHS S VGN K ++ GG N R +D++ ++L G
Sbjct: 131 GPPPCPRLGHSFSL---VGN----KCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSG 183
Query: 72 KHQWDLDTCKGLLP--RYEHASFI---PSCTPDRIWVFGGANQSGNR-NCLQVLNPETRT 125
WD+ G+LP R H + + ++ ++GG SG R L L+ +T T
Sbjct: 184 VVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGG--MSGCRLGDLWTLDIDTLT 241
Query: 126 WTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG-------GERGAQPVQDTK----LHVFD 174
W P ++ P PR+ H S+ IGN++YVFGG + A ++ K L +
Sbjct: 242 WNKPSLSGVAPLPRSLH-SATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLN 300
Query: 175 ANTLTWSQ--PETL-GNPPSPRHGHVMVAAGTKLFIHGGLAGDR--FYDDLHCIDISDMK 229
+T+ W +TL N P R GH VA T+L+I G G R + + + C D+ ++
Sbjct: 301 LDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLE 360
Query: 230 WQKLNP 235
+K P
Sbjct: 361 TEKPPP 366
Score = 59.3 bits (142), Expect = 5e-09
Identities = 38/120 (31%), Positives = 53/120 (44%), Gaps = 6/120 (5%)
Query: 187 GNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAH 246
G P PRHGH VA + + GG + D+LH + + +W G P GCAA+
Sbjct: 27 GPVPRPRHGHRAVAIKELIVVFGG-GNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAY 85
Query: 247 SAVAMGKHVYIFGGMTPAGAL-DTMYQYHTEEQHWTLLKFDTLL----PPGRLDHSMCII 301
V G + +FGGM G + +Y+ W LK T P RL HS ++
Sbjct: 86 GFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLV 145
Score = 58.2 bits (139), Expect = 1e-08
Identities = 70/284 (24%), Positives = 108/284 (38%), Gaps = 54/284 (19%)
Query: 18 WYTLTVPGDSP--CARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFS-DVHTMDLGKHQ 74
W+ V GD P CA G C ++ + GG +S D++ + + +
Sbjct: 69 WFIPAVRGDIPPGCAAYGFVCDGT---------RLLVFGGMVEYGKYSNDLYELQASRWE 119
Query: 75 WD---LDTCKGLLPRYEHASFIPSCTPDRIWVFGG-ANQSGN--RNCLQVLNP----ETR 124
W T K P S ++ ++FGG AN S + N + LN E R
Sbjct: 120 WKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELR 179
Query: 125 ------TWTTPEVTSPPPSPRTFHTSSAAIG-----NQLYVFGGGERGAQPVQDTKLHVF 173
W P P PR HT+ ++L ++GG + L
Sbjct: 180 PGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGG----MSGCRLGDLWTL 235
Query: 174 DANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGG---LAGD-----------RFYDD 219
D +TLTW++P G P PR H G K+++ GG L D + +
Sbjct: 236 DIDTLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNT 295
Query: 220 LHCIDISDMKWQKL---NPTGAAPAGCAAHSAVAMGKHVYIFGG 260
L C+++ M W+ + P A H AVA+ +YI+ G
Sbjct: 296 LACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSG 339
Score = 32.7 bits (73), Expect = 0.54
Identities = 18/65 (27%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 229 KWQKL-NPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDT 287
+W+++ +G P H AVA+ + + +FGG G +D ++ Y+T W +
Sbjct: 18 RWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGN-EGIVDELHVYNTATNQWFIPAVRG 76
Query: 288 LLPPG 292
+PPG
Sbjct: 77 DIPPG 81
>gi|7019405 host cell factor C2 [Homo sapiens]
Length = 792
Score = 94.0 bits (232), Expect = 2e-19
Identities = 83/279 (29%), Positives = 115/279 (41%), Gaps = 34/279 (12%)
Query: 25 GDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLL 84
G P AR GH A R + I GG N + ++H + +QW L +G +
Sbjct: 17 GPVPRARHGHRAV-------AIRELMIIFGGGNEGIA-DELHVYNTATNQWFLPAVRGDI 68
Query: 85 PRYEHA-SFIPSCTPDRIWVFGGANQSGN-RNCLQVLNPETRTWTT----PEVTSPPPSP 138
P A F+ C RI VFGG + G N L L W P + PP P
Sbjct: 69 PPGCAAHGFV--CDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPHPPPSGLPPCP 126
Query: 139 RTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFD----------ANTLTWSQPETLGN 188
R H+ S GN+ Y+FGG ++ + + + + WS P T G
Sbjct: 127 RLGHSFSL-YGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGV 185
Query: 189 PPSPRHGHVMV------AAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAG 242
PSPR H V + K+++ GG+ G R DDL +D+ M W K G P
Sbjct: 186 VPSPRESHTAVIYCKKDSGSPKMYVFGGMCGARL-DDLWQLDLETMSWSKPETKGTVPLP 244
Query: 243 CAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWT 281
+ H+A +G +YIFGG P +T H E T
Sbjct: 245 RSLHTASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCT 283
Score = 79.3 bits (194), Expect = 5e-15
Identities = 72/226 (31%), Positives = 102/226 (45%), Gaps = 48/226 (21%)
Query: 25 GDSPCARVGHSCSYLPPVGNAKRGKVFIVGGA---------NPNRSFSDVHTMDL----G 71
G PC R+GHS S GN K ++ GG N R +D + ++L G
Sbjct: 121 GLPPCPRLGHSFSLY---GN----KCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSG 173
Query: 72 KHQWDLDTCKGLLP--RYEHASFIPSCTPD----RIWVFGGANQSGNR-NCLQVLNPETR 124
W + KG++P R H + I C D +++VFGG G R + L L+ ET
Sbjct: 174 VVGWSIPVTKGVVPSPRESHTAVI-YCKKDSGSPKMYVFGG--MCGARLDDLWQLDLETM 230
Query: 125 TWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG-----GERGAQPVQD------TKLHVF 173
+W+ PE P PR+ HT+S IGN++Y+FGG GE D +
Sbjct: 231 SWSKPETKGTVPLPRSLHTASV-IGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYL 289
Query: 174 DANTLTW------SQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAG 213
+ +T W SQ + + P PR GH VA GT+L+ G G
Sbjct: 290 NLDTTEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSGRDG 335
Score = 65.1 bits (157), Expect = 1e-10
Identities = 62/212 (29%), Positives = 80/212 (37%), Gaps = 37/212 (17%)
Query: 178 LTWSQPETLGNP-PSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPT 236
L W + + P P RHGH VA + I GG + D+LH + + +W
Sbjct: 7 LNWRRVSSFTGPVPRARHGHRAVAIRELMIIFGG-GNEGIADELHVYNTATNQWFLPAVR 65
Query: 237 GAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPG---- 292
G P GCAAH V G + +FGGM G Y + W K PP
Sbjct: 66 GDIPPGCAAHGFVCDGTRILVFGGMVEYGRYSNEL-YELQASRWLWKKVKPHPPPSGLPP 124
Query: 293 --RLDHSMCIIPWPVTC------ASEKEDSNS-----------LTLNHEAEKEDSADKVM 333
RL HS + + C A+E EDSN+ L L H + + V
Sbjct: 125 CPRLGHSFSL--YGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVT 182
Query: 334 SHSGDSHEESQTATLLC---------LVFGGM 356
S ES TA + C VFGGM
Sbjct: 183 KGVVPSPRESHTAVIYCKKDSGSPKMYVFGGM 214
Score = 62.0 bits (149), Expect = 8e-10
Identities = 75/294 (25%), Positives = 113/294 (38%), Gaps = 71/294 (24%)
Query: 18 WYTLTVPGDSP--CARVGHSCSYLPPVGNAKRGKVFIVGG-ANPNRSFSDVHTMDLGKHQ 74
W+ V GD P CA G C ++ + GG R ++++ + +
Sbjct: 59 WFLPAVRGDIPPGCAAHGFVCDGT---------RILVFGGMVEYGRYSNELYELQASRWL 109
Query: 75 WD----------LDTCKGLLPRYEHASFIPSCTPDRIWVFGG-ANQS--GNRNCLQVLNP 121
W L C PR H+ S ++ ++FGG AN+S N N + LN
Sbjct: 110 WKKVKPHPPPSGLPPC----PRLGHSF---SLYGNKCYLFGGLANESEDSNNNVPRYLND 162
Query: 122 ETRT----------WTTPEVTSPPPSPRTFHTS-----SAAIGNQLYVFGGGERGAQPVQ 166
W+ P PSPR HT+ + ++YVFGG GA+ +
Sbjct: 163 FYELELQHGSGVVGWSIPVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGG-MCGAR-LD 220
Query: 167 DTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGD------------ 214
D L D T++WS+PET G P PR H G K++I GG
Sbjct: 221 D--LWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTETSPHDC 278
Query: 215 --RFYDDLHCIDISDMKWQKL------NPTGAAPAGCAAHSAVAMGKHVYIFGG 260
R +++ +W L + + P A H AVA+G +Y + G
Sbjct: 279 EWRCTSSFSYLNLDTTEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSG 332
>gi|7657301 kelch domain containing 2 [Homo sapiens]
Length = 406
Score = 90.1 bits (222), Expect = 3e-18
Identities = 76/292 (26%), Positives = 116/292 (39%), Gaps = 46/292 (15%)
Query: 65 VHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETR 124
++ M+ G+ W +G +P S C +++FGG + GN N +L+ +
Sbjct: 70 IYNMETGR--WKKINTEGDVPPSMSGS-CAVCVDRVLYLFGGHHSRGNTNKFYMLDSRST 126
Query: 125 T----WTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDT----------- 168
W + PPS + N+L FGG G V T
Sbjct: 127 DRVLQWERIDCQGIPPSSKD-KLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 185
Query: 169 --------KLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDL 220
+H+ D T TWSQP T G PSPR H G + F+ GG D +DL
Sbjct: 186 SHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDL 245
Query: 221 HCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGK-HVYIFGGM-TPAGALDTMYQYHTEEQ 278
H +++ +W +L P G P G + HS + H+++FGG T L + Y +
Sbjct: 246 HYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKN 305
Query: 279 HWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKED-------SNSLTLNHEA 323
W P RL W CAS++ + +N+L ++H A
Sbjct: 306 EWIQFNHPYTEKP-RL--------WHTACASDEGEVIVFGGCANNLLVHHRA 348
Score = 57.0 bits (136), Expect = 3e-08
Identities = 51/214 (23%), Positives = 82/214 (38%), Gaps = 33/214 (15%)
Query: 113 RNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGE-RGAQPVQDTKLH 171
R L + N ET W P P + + + LY+FGG RG K +
Sbjct: 65 REELWIYNMETGRWKKINTEGDVP-PSMSGSCAVCVDRVLYLFGGHHSRG----NTNKFY 119
Query: 172 VFDANT----LTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGG---LAGDR--------- 215
+ D+ + L W + + G PPS + + KL GG L D+
Sbjct: 120 MLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDE 179
Query: 216 -----------FYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPA 264
+ D +H +D W + TG AP+ AAH+ +G ++FGG
Sbjct: 180 TSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRD 239
Query: 265 GALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSM 298
++ ++ + + W L + P GR HS+
Sbjct: 240 ARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSL 273
Score = 47.8 bits (112), Expect = 2e-05
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 9/91 (9%)
Query: 190 PSPRHGHVMVAAGTKLFIHGGLAGDR------FY---DDLHCIDISDMKWQKLNPTGAAP 240
P+ R GHV V+ G +F+ GG ++ FY ++L ++ +W+K+N G P
Sbjct: 29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
Query: 241 AGCAAHSAVAMGKHVYIFGGMTPAGALDTMY 271
+ AV + + +Y+FGG G + Y
Sbjct: 89 PSMSGSCAVCVDRVLYLFGGHHSRGNTNKFY 119
Score = 45.4 bits (106), Expect = 8e-05
Identities = 38/149 (25%), Positives = 63/149 (42%), Gaps = 23/149 (15%)
Query: 17 TWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWD 76
TW G +P R H+C+ VGN RG F+ GG + +D+H ++L +W+
Sbjct: 204 TWSQPITTGKAPSPRAAHACA---TVGN--RG--FVFGGRYRDARMNDLHYLNLDTWEWN 256
Query: 77 LDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWT-------TP 129
+G+ P + + D +++FGG P + WT
Sbjct: 257 ELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTD--------KQPLSDAWTYCISKNEWI 308
Query: 130 EVTSP-PPSPRTFHTSSAAIGNQLYVFGG 157
+ P PR +HT+ A+ ++ VFGG
Sbjct: 309 QFNHPYTEKPRLWHTACASDEGEVIVFGG 337
>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
Length = 840
Score = 81.3 bits (199), Expect = 1e-15
Identities = 55/213 (25%), Positives = 96/213 (45%), Gaps = 14/213 (6%)
Query: 99 DRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG- 157
D I+VFGG N N L + + +W T PP+PR +H S+ G+ ++VFGG
Sbjct: 78 DAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPR-YHHSAVVYGSSMFVFGGY 136
Query: 158 -GERGAQPVQDTKLHVFDANTLT--WSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGD 214
G+ + K +F+ T W++ + G P R H KL+I G G+
Sbjct: 137 TGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGN 196
Query: 215 RFYDDLHCIDISDMK---WQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMY 271
+D+ I + D + W+++ +G P C +++F G + A + ++
Sbjct: 197 ARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLF 256
Query: 272 QYHTEEQHWTLLKFDTLL------PPGRLDHSM 298
Q+ +++ WT + + LL P R H+M
Sbjct: 257 QFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTM 289
Score = 73.2 bits (178), Expect = 4e-13
Identities = 65/250 (26%), Positives = 108/250 (43%), Gaps = 34/250 (13%)
Query: 14 RKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGG------ANPN-RSFSDVH 66
+ +W G P R HS +F+ GG +N N ++ +D+
Sbjct: 101 KDCSWCRAFTTGTPPAPRYHHSAVVYG-------SSMFVFGGYTGDIYSNSNLKNKNDLF 153
Query: 67 TMDLGKHQWDLDTCKGLLP--RYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETR 124
QW +G LP R H + + S D++W+F G + + N + + + R
Sbjct: 154 EYKFATGQWTEWKIEGRLPVARSAHGATVYS---DKLWIFAGYDGNARLNDMWTIGLQDR 210
Query: 125 TWTTPEVTSP----PPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTW 180
T E + PPS F A ++++VF G + GA+ + L F+ TW
Sbjct: 211 ELTCWEEVAQSGEIPPSCCNFPV--AVCRDKMFVFSG-QSGAKITNN--LFQFEFKDKTW 265
Query: 181 SQPET----LGNPPSP--RHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLN 234
++ T G+PP P R+GH MVA L++ GG A + ++LHC D+ W+ +
Sbjct: 266 TRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQ 325
Query: 235 PTGAAPAGCA 244
P+ + G A
Sbjct: 326 PSSDSEVGGA 335
Score = 67.0 bits (162), Expect = 3e-11
Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 13/171 (7%)
Query: 139 RTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVM 198
R+ HT A + +YVFGG + G + D L FD +W + T G PP+PR+ H
Sbjct: 68 RSKHTV-VAYKDAIYVFGG-DNGKTMLND--LLRFDVKDCSWCRAFTTGTPPAPRYHHSA 123
Query: 199 VAAGTKLFIHGGLAGDRF-------YDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAM 251
V G+ +F+ GG GD + +DL + +W + G P +AH A
Sbjct: 124 VVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVY 183
Query: 252 GKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCIIP 302
++IF G L+ M+ +++ T ++ + G + S C P
Sbjct: 184 SDKLWIFAGYDGNARLNDMWTIGLQDRELTC--WEEVAQSGEIPPSCCNFP 232
Score = 66.2 bits (160), Expect = 4e-11
Identities = 53/255 (20%), Positives = 102/255 (40%), Gaps = 19/255 (7%)
Query: 45 AKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGL--LPRYEHASFIPSCTPDRIW 102
A + +++ GG N +D+ D+ W G PRY H++ + + ++
Sbjct: 75 AYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSS---MF 131
Query: 103 VFGGA-------NQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVF 155
VFGG + N+N L T WT ++ P R+ H + ++L++F
Sbjct: 132 VFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAH-GATVYSDKLWIF 190
Query: 156 GGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDR 215
G + A+ + + D W + G P + K+F+ G +G +
Sbjct: 191 AGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAK 250
Query: 216 FYDDLHCIDISDMKWQK------LNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDT 269
++L + D W + L + P H+ VA +H+Y+FGG +
Sbjct: 251 ITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNE 310
Query: 270 MYQYHTEEQHWTLLK 284
++ Y + Q W +++
Sbjct: 311 LHCYDVDFQTWEVVQ 325
Score = 62.0 bits (149), Expect = 8e-10
Identities = 63/257 (24%), Positives = 98/257 (38%), Gaps = 27/257 (10%)
Query: 18 WYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQ--- 74
W + G P AR H + K++I G + N +D+ T+ L +
Sbjct: 162 WTEWKIEGRLPVARSAHGATVYSD-------KLWIFAGYDGNARLNDMWTIGLQDRELTC 214
Query: 75 WDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVT-- 132
W+ G +P +F + D+++VF G + + N L + +TWT
Sbjct: 215 WEEVAQSGEIPP-SCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHL 273
Query: 133 ---SPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWS--QPET-- 185
SPPP R + + A LYVFGG P +LH +D + TW QP +
Sbjct: 274 LRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLP---NELHCYDVDFQTWEVVQPSSDS 330
Query: 186 -LGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKW-QKLNPTGAAPAGC 243
+G P T + G + D+ +D Q P P+G
Sbjct: 331 EVGGAEVPERACASEEVPTLTYEER--VGFKKSRDVFGLDFGTTSAKQPTQPASELPSGR 388
Query: 244 AAHSAVAMGKHVYIFGG 260
H+A + +YIFGG
Sbjct: 389 LFHAAAVISDAMYIFGG 405
>gi|16945972 kelch domain containing 3 [Homo sapiens]
Length = 382
Score = 80.1 bits (196), Expect = 3e-15
Identities = 71/264 (26%), Positives = 106/264 (40%), Gaps = 48/264 (18%)
Query: 39 LPPVGNAKRGKVFIV-------------------GGANPNRSFSDV-HTMDLGKHQWDLD 78
LPPV +A RG+ +V GG N +V + D+ H+W
Sbjct: 59 LPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTP 118
Query: 79 TCKGLLP--RYEHASFIPSCTPDRI-WVFGGANQSGN--RNCLQVLNPETRTWTTPEVTS 133
G +P R H++ C +I ++FGG Q + N + L+ T TWT
Sbjct: 119 RVSGTVPGARDGHSA----CVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKG 174
Query: 134 PPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDT------KLHVFDANTLTWSQPETLG 187
P R FH S+ +G+ +YVFGG P ++ VFD T W L
Sbjct: 175 SPARWRDFH-SATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW-----LD 228
Query: 188 NPPSP-----RHGHVMVAAGTKLFIHGGLAG--DRFYDDLHCIDISDMKWQKLNPTGAAP 240
PP+P R H +L+I GG +R + DL + W+K+ P G P
Sbjct: 229 CPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGP 288
Query: 241 AGCAAHSAVAMGKHVYIFGGMTPA 264
+G + +FGG +P+
Sbjct: 289 CPRRRQCCCIVGDKIVLFGGTSPS 312
Score = 75.1 bits (183), Expect = 9e-14
Identities = 60/220 (27%), Positives = 89/220 (40%), Gaps = 23/220 (10%)
Query: 100 RIWVFGGANQSGNRNCLQ-----VLNPETRTWTT-PEVTSP-----PPSPRTFHTSSAAI 148
R++ FGG + L+ + N + WT P V S P P + S +
Sbjct: 25 RVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHSTVL 84
Query: 149 GNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIH 208
+ + GG + + L+ FD NT W P G P R GH G ++I
Sbjct: 85 IDDTVLLWGGRNDTEGACNV-LYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIF 143
Query: 209 GGLA--GDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMT---- 262
GG D F +D+H +D S M W + G+ HSA +G H+Y+FGG
Sbjct: 144 GGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFG 203
Query: 263 PAGALDTMY-----QYHTEEQHWTLLKFDTLLPPGRLDHS 297
P + + +Y + T + W +LP GR HS
Sbjct: 204 PFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHS 243
Score = 68.9 bits (167), Expect = 7e-12
Identities = 65/235 (27%), Positives = 95/235 (40%), Gaps = 40/235 (17%)
Query: 18 WYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRS---FSDVHTMDLGKHQ 74
W+T V G P AR GHS L GK+ + G ++ +D+H +D
Sbjct: 115 WFTPRVSGTVPGARDGHSACVL--------GKIMYIFGGYEQQADCFSNDIHKLDTSTMT 166
Query: 75 WDLDTCKGLLPRYE--HASFIPSCTPDRIWVFGG---------ANQSGNRNCLQVLNPET 123
W L KG R+ H++ + ++VFGG +N N ++V + T
Sbjct: 167 WTLICTKGSPARWRDFHSA---TMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRT 223
Query: 124 RTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDTKLHVFDANTLTWSQ 182
W T P R H S+ +LY+FGG R + D L F+ + TW +
Sbjct: 224 EAWLDCPPTPVLPEGRRSH-SAFGYNGELYIFGGYNARLNRHFHD--LWKFNPVSFTWKK 280
Query: 183 PETLGNPPSPRHGHVMVAAGTKLFIHGGLA-------GDRF----YDDLHCIDIS 226
E G P PR G K+ + GG + GD F + DLH +D S
Sbjct: 281 IEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFS 335
Score = 50.4 bits (119), Expect = 2e-06
Identities = 32/123 (26%), Positives = 51/123 (41%), Gaps = 14/123 (11%)
Query: 193 RHGHVMVAAGTKLFIHGGLAGDRFYD-----DLHCIDISDMKWQKLNPTGAAPAGCA--- 244
R H VA G +++ GG Y+ D+H + ++W KL P +A G A
Sbjct: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVV 73
Query: 245 -----AHSAVAMGKHVYIFGGMTPA-GALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSM 298
HS V + V ++GG GA + +Y + W + +P R HS
Sbjct: 74 PYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSA 133
Query: 299 CII 301
C++
Sbjct: 134 CVL 136
>gi|21314675 kelch domain containing 4 [Homo sapiens]
Length = 520
Score = 77.4 bits (189), Expect = 2e-14
Identities = 66/210 (31%), Positives = 94/210 (44%), Gaps = 21/210 (10%)
Query: 67 TMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNR----NCLQVLNPE 122
T+D + Q C PR +AS D + +FGG +G + N L V N
Sbjct: 45 TLDAKRTQTVELPCPPPSPRL-NASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTR 103
Query: 123 TRTWTTPEVTSPPPSPRTFHTSSAAI--GNQLYVFGG---GERGAQPVQDTKLHVFDANT 177
TWT ++ SPPP R H + G QL+VFGG G Q L V T
Sbjct: 104 KDTWTKVDIPSPPPR-RCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLAT 162
Query: 178 LTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDR----FYDDLHCIDISDMKWQKL 233
TW Q ++ G P S R GH MVA +L + GG +Y+D++ ++ W KL
Sbjct: 163 KTWEQVKSTGGP-SGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKL 221
Query: 234 NPTGAAP---AGCAAHSAVAMGKHVYIFGG 260
+P+G P +GC +V + ++GG
Sbjct: 222 SPSGTGPTPRSGC--QMSVTPQGGIVVYGG 249
Score = 62.4 bits (150), Expect = 6e-10
Identities = 68/270 (25%), Positives = 114/270 (42%), Gaps = 35/270 (12%)
Query: 20 TLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGA--NPNRSF--SDVHTMDLGKHQW 75
T+ +P P R+ S S P ++ ++ + GG N ++F ++++ + K W
Sbjct: 53 TVELPCPPPSPRLNASLSVHP-----EKDELILFGGEYFNGQKTFLYNELYVYNTRKDTW 107
Query: 76 DLDTCKGLLPRY-EHASFIPSCTPDRIWVFGGANQSGNRNC------LQVLNPETRTWTT 128
PR H + + ++WVFGG S N L VL+ T+TW
Sbjct: 108 TKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQ 167
Query: 129 PEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQP-VQDTKLHVFDANTLTWSQPETLG 187
+ T P S R+ H A QL +FGG + + ++ F+ +T TWS+ G
Sbjct: 168 VKSTGGP-SGRSGHRM-VAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSG 225
Query: 188 NPPSPRHGHVM-VAAGTKLFIHGGLAGDRF---------YDDLHCIDISDMK-----WQK 232
P+PR G M V + ++GG + R + D+ + D + W +
Sbjct: 226 TGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTR 285
Query: 233 LNPTGAAPAGCAAHS-AVAMGKHVYIFGGM 261
+NP+G P + S A+A FGG+
Sbjct: 286 MNPSGVKPTPRSGFSVAMAPNHQTLFFGGV 315
>gi|44917619 kelch domain containing 10 [Homo sapiens]
Length = 442
Score = 72.4 bits (176), Expect = 6e-13
Identities = 74/299 (24%), Positives = 114/299 (38%), Gaps = 38/299 (12%)
Query: 28 PCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRS------------FSDVHTMDLGKHQW 75
P AR GH C A +++ GG NP+ F ++ W
Sbjct: 89 PPARSGHRCV-------ADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVW 141
Query: 76 DLDTCKGLLPRYEHASFIPSCTPDRIWVFGGAN---QSGNRNCLQVLNPETRTWTTPEVT 132
G +PR E AS + + VFGG N N + V N + + W
Sbjct: 142 HQMGTDGYMPR-ELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR 200
Query: 133 SPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQ--PETLG-NP 189
PS R + + A I LYVFGG + T LH D NT W+Q P L +
Sbjct: 201 GKKPS-RIYGQAMAIINGSLYVFGGT---TGYIYSTDLHKLDLNTREWTQLKPNNLSCDL 256
Query: 190 PSPRHGHVMVAAGTKLFIHGGLAGDRFY--DDLHCIDISDMKWQKL----NPTGAAPAGC 243
P R+ H + G +++I GG Y + +H ++ W+++ + PA
Sbjct: 257 PEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAAR 316
Query: 244 AAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCIIP 302
HS V + V+I GG L +++ + + W +K +P H + P
Sbjct: 317 RCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW--VKLPATMPEPVYFHCAAVTP 373
Score = 61.6 bits (148), Expect = 1e-09
Identities = 54/207 (26%), Positives = 85/207 (41%), Gaps = 13/207 (6%)
Query: 63 SDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPE 122
+DVH ++ +W L +C+G P + + + ++VFGG L L+
Sbjct: 182 NDVHVCNVKYKRWALLSCRGKKPSRIYGQAM-AIINGSLYVFGGTTGYIYSTDLHKLDLN 240
Query: 123 TRTWTT--PEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTW 180
TR WT P S + A G ++Y+ GGG K+H ++ T W
Sbjct: 241 TREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTA-YSLNKIHAYNLETNAW 299
Query: 181 SQPETLGNP----PSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPT 236
+ T + P+ R H V +FI GG G+ D+ +++ +W KL T
Sbjct: 300 EEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAT 359
Query: 237 GAAPA--GCAAHSAVAMGKHVYIFGGM 261
P CA AV +YI GG+
Sbjct: 360 MPEPVYFHCA---AVTPAGCMYIHGGV 383
Score = 52.8 bits (125), Expect = 5e-07
Identities = 48/179 (26%), Positives = 72/179 (40%), Gaps = 16/179 (8%)
Query: 135 PPSPRTFHTSSAAIGNQLYVFGG-----GERGAQPVQD----TKLHVFDANTLTWSQPET 185
PP R+ H A N LYVFGG E G +D +L + T W Q T
Sbjct: 88 PPPARSGHRCVADNTN-LYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGT 146
Query: 186 LGNPPSPRHGHVMVAAGTKLFIHGGLA---GDRFYDDLHCIDISDMKWQKLNPTGAAPAG 242
G P +V G L + GG G+ +D+H ++ +W L+ G P+
Sbjct: 147 DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSR 206
Query: 243 CAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTL---LPPGRLDHSM 298
+ + +Y+FGG T +++ + WT LK + L LP R H +
Sbjct: 207 IYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEI 265
Score = 45.8 bits (107), Expect = 6e-05
Identities = 59/237 (24%), Positives = 90/237 (37%), Gaps = 38/237 (16%)
Query: 18 WYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDL 77
W L+ G P G + + + G +++ GG +D+H +DL +W
Sbjct: 194 WALLSCRGKKPSRIYGQAMAII-------NGSLYVFGGTTGYIYSTDLHKLDLNTREWTQ 246
Query: 78 DTCKGL---LP--RYEHASFIPSCTPDRIWVFGGANQ--SGNRNCLQVLNPETRTW---- 126
L LP RY H + RI++ GG + + N + N ET W
Sbjct: 247 LKPNNLSCDLPEERYRHEI---AHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIA 303
Query: 127 TTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG--GERGAQPVQDTKLHVFDANTLTWSQPE 184
T P P+ R H S I N +++ GG GE + L F L + PE
Sbjct: 304 TKPHEKIGFPAARRCH-SCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPE 362
Query: 185 TLGNPPSPRHGHVMVAAGTKLFIHGGL--------AGDRFYDDLHCIDISDMKWQKL 233
P H + AG ++IHGG+ G F L + ++ W+KL
Sbjct: 363 -----PVYFHCAAVTPAGC-MYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKL 413
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 62.4 bits (150), Expect = 6e-10
Identities = 52/225 (23%), Positives = 86/225 (38%), Gaps = 27/225 (12%)
Query: 71 GKHQWDLDTCKGLLPRYEHASFIPSCTP-----------DRIWVFGG---ANQSGNRNCL 116
G Q +D + P+ + SF+PS T DRI+V GG ++ + CL
Sbjct: 290 GSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECL 349
Query: 117 QVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDAN 176
E W + P + R + +G+ +YV GG + + T + +D N
Sbjct: 350 DYTADEDGVW----YSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRR---HTSMERYDPN 402
Query: 177 TLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPT 236
WS LG+ + R G +V A ++ GG G + + D W + P
Sbjct: 403 IDQWSM---LGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPM 459
Query: 237 GAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWT 281
+G + H+Y+ GG L ++ Y+ WT
Sbjct: 460 ATKRSGAGV---ALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWT 501
Score = 38.5 bits (88), Expect = 0.010
Identities = 38/172 (22%), Positives = 66/172 (38%), Gaps = 13/172 (7%)
Query: 115 CLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFD 174
C +++ + PE+ S PRT A +G + G G+Q + +D
Sbjct: 248 CRDLVDEAKKFHLRPELRSQMQGPRT----RARLGANEVLLVVGGFGSQQSPIDVVEKYD 303
Query: 175 ANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDIS---DMKWQ 231
T WS L + R V+ ++++ GG G + C+D + D W
Sbjct: 304 PKTQEWS---FLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY 360
Query: 232 KLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLL 283
+ P G A A +G +Y+ GG + +M +Y W++L
Sbjct: 361 SVAPMNVR-RGLAG--ATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSML 409
>gi|26190616 kelch domain containing 1 [Homo sapiens]
Length = 406
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/154 (29%), Positives = 70/154 (45%), Gaps = 8/154 (5%)
Query: 111 GNRNCLQVLNPETRTWTTPEVTSP-PPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTK 169
G N + + + +T+TW PE+ PP PR HT A +GN+ Y+FGG +
Sbjct: 168 GWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTC-AVLGNKGYIFGG---RVLQTRMND 223
Query: 170 LHVFDANTLTWSQPETL-GNPPSPRHGHVMV-AAGTKLFIHGGLAGDRF-YDDLHCIDIS 226
LH + +T TWS T+ G P R H + A KLF+ GGL+ D D +++
Sbjct: 224 LHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVT 283
Query: 227 DMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGG 260
W++L + + + +FGG
Sbjct: 284 TNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGG 317
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/225 (23%), Positives = 88/225 (39%), Gaps = 41/225 (18%)
Query: 64 DVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPET 123
++ T D+ W + +G LP S +C ++++FGG + G N L +N T
Sbjct: 45 EIWTYDIDSGLWRMHLMEGELPASMSGS-CGACINGKLYIFGGYDDKGYSNRLYFVNLRT 103
Query: 124 R--TWTTPEVTS---PPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDTKLHVFDANT 177
R T+ ++T PP+PR S ++L FGG G R +QD FD +
Sbjct: 104 RDETYIWEKITDFEGQPPTPRD-KLSCWVYKDRLIYFGGYGCRRHSELQDC----FDVHD 158
Query: 178 LTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKW-QKLNPT 236
+W + G +++D+H D W Q
Sbjct: 159 ASWEEQIFWG----------------------------WHNDVHIFDTKTQTWFQPEIKG 190
Query: 237 GAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWT 281
G P AAH+ +G YIFGG ++ ++ + + W+
Sbjct: 191 GVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWS 235
Score = 52.0 bits (123), Expect = 9e-07
Identities = 43/166 (25%), Positives = 69/166 (41%), Gaps = 6/166 (3%)
Query: 63 SDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPE 122
+DVH D W KG +P A+ + ++ ++FGG N L LN +
Sbjct: 171 NDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLD 230
Query: 123 TRTWT-TPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWS 181
T TW+ + P R++HT + ++L++ GG P+ D +H + T W
Sbjct: 231 TWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIH--NVTTNCWK 288
Query: 182 QPETLGNPPSPRHGH-VMVAAGTKLFIHGGLAGDRF-YDDLHCIDI 225
Q L PR H + ++ + GG D D HC D+
Sbjct: 289 QLTHLPK-TRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDL 333
Score = 35.8 bits (81), Expect = 0.064
Identities = 23/85 (27%), Positives = 35/85 (41%), Gaps = 6/85 (7%)
Query: 193 RHGHVMVAAGTKLFIHGG---LAGDRFY---DDLHCIDISDMKWQKLNPTGAAPAGCAAH 246
R GH V G L++ GG + + Y D++ DI W+ G PA +
Sbjct: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
Query: 247 SAVAMGKHVYIFGGMTPAGALDTMY 271
+ +YIFGG G + +Y
Sbjct: 73 CGACINGKLYIFGGYDDKGYSNRLY 97
>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
Length = 2778
Score = 57.4 bits (137), Expect = 2e-08
Identities = 64/225 (28%), Positives = 89/225 (39%), Gaps = 27/225 (12%)
Query: 78 DTCKGLLPRYEHASFI-PSCTPDRIWVFGGAN-QSGNRNCLQVLNPETRTWTT----PEV 131
DT L R H P T +W+FGG G L + R WT E
Sbjct: 1435 DTASRFLHRLGHTMVDGPDAT---LWMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAED 1491
Query: 132 TSPPPSPRTFHTSS--AAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQ---PETL 186
P PSPR+FH ++ A +Y+ GG G V + TL W Q P+T+
Sbjct: 1492 GGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGG---VTRDFWVLNLTTLQWRQEKAPQTV 1548
Query: 187 GNPPSPRHGHVMVA-AGTKLFIHGGLAGDR-FYDDLHCIDISDMKWQKLNPTGAAPAGCA 244
P GH + A G L + GG + + F L ++ W +G P G
Sbjct: 1549 ELPAVA--GHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLY 1606
Query: 245 AHSAV--AMGKHVYIFGG----MTPAGALDTMYQYHTEEQHWTLL 283
HSAV +Y+FGG + A +Y H ++ W+LL
Sbjct: 1607 GHSAVYHEATDSLYVFGGFRFHVELAAPSPELYSLHCPDRTWSLL 1651
Score = 46.2 bits (108), Expect = 5e-05
Identities = 46/157 (29%), Positives = 71/157 (45%), Gaps = 14/157 (8%)
Query: 152 LYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVA-AGTKLFIHGG 210
L VFGG + + D L+ F ANT W + L P+ RH HV VA AG+ + + G
Sbjct: 242 LAVFGGQDLN-NALGDLVLYNFSANT--WESWD-LSPAPAARHSHVAVAWAGSLVLMGGE 297
Query: 211 LAGDRFYDDLHCID-ISDMKWQKLNP---TGAAPAGCAAHSAVAMGK-HVYIFGGMTPAG 265
LA +D+ + W+ L P + + P G A H+A + +Y+ GG TP
Sbjct: 298 LADGSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHD 357
Query: 266 ALDT-MYQYH---TEEQHWTLLKFDTLLPPGRLDHSM 298
+ ++++ T +W + PP HSM
Sbjct: 358 LFSSGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSM 394
Score = 43.9 bits (102), Expect = 2e-04
Identities = 65/300 (21%), Positives = 117/300 (39%), Gaps = 38/300 (12%)
Query: 18 WYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDL 77
W+ ++ + AR+G + ++L P G + + GG + N + D+ + + W+
Sbjct: 215 WHNVSARDPAFSARIGAAGAFLSPPG-----LLAVFGGQDLNNALGDLVLYNFSANTWES 269
Query: 78 -DTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGN-RNCLQVLNPETRT-WTTPEVTSP 134
D R+ H + + + GG G+ N + +P R W E+ +P
Sbjct: 270 WDLSPAPAARHSHVAV---AWAGSLVLMGGELADGSLTNDVWAFSPLGRGHW---ELLAP 323
Query: 135 PPS----PRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLT---WSQPETLG 187
P S P +AA+ + ++++ G R + + L F ++ + W Q G
Sbjct: 324 PASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFSSGLFRFRLDSTSGGYWEQVIPAG 383
Query: 188 NPPSPRHGHVMV--AAGTKLFIHGGLAGD--RFYDDLHCIDISDMK---WQKLNPTGA-- 238
P GH MV A L +HGG RF ++ ++ + W L
Sbjct: 384 GRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWTTLKGRDGLQ 443
Query: 239 APAGCAAHSAVAMGKHVYIFGGMTPAGAL------DTMYQYHTEEQHWTLLKFDTLLPPG 292
P A H+A +G ++ ++GG D ++ YH W + L PPG
Sbjct: 444 GPRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQW--VSGAELAPPG 501
Score = 42.0 bits (97), Expect = 9e-04
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 136 PSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPE-----TLGNPP 190
P PR FH +SA +G+ + V GG + D L+ + N W P+ ++G P
Sbjct: 1715 PRPRLFH-ASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNA--WLLPDLTRSASVGPPM 1771
Query: 191 SPRHGHVMVAAGTKLFIHGGLAG 213
H + A G++L+I GG G
Sbjct: 1772 EESVAHAVAAVGSRLYISGGFGG 1794
Score = 41.6 bits (96), Expect = 0.001
Identities = 60/235 (25%), Positives = 93/235 (39%), Gaps = 22/235 (9%)
Query: 45 AKRG-KVFIVGGANPNRSFSD-VHTMDLGKHQWDLDTCKGLLPR--YEHASFIPSCTPDR 100
A+RG + +VGG +P F+ + L W G P Y H++ T D
Sbjct: 1560 ARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEAT-DS 1618
Query: 101 IWVFGG----ANQSGNRNCLQVLNPETRTWT--TPEVTSPPPSPRTFHTSSAAIGNQLYV 154
++VFGG + L L+ RTW+ P + R SS +G Q+
Sbjct: 1619 LYVFGGFRFHVELAAPSPELYSLHCPDRTWSLLAPSQGAKRDRMRNVRGSSRGLG-QVPG 1677
Query: 155 FGGGERGAQPVQDTKLHVFDANTLTWSQPETLG---NPPSPRHGHVMVAAGTKLFIHGGL 211
G G + V+ K+ ++ A T E + P PR H G + + GG
Sbjct: 1678 EQPGSWGFREVRK-KMALWAALAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVLGGR 1736
Query: 212 AG-DRFYDDLHCIDISDMKWQKLNPTGAAPAG-----CAAHSAVAMGKHVYIFGG 260
+ D F D+ ++ W + T +A G AH+ A+G +YI GG
Sbjct: 1737 SDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGG 1791
Score = 41.2 bits (95), Expect = 0.002
Identities = 54/230 (23%), Positives = 83/230 (36%), Gaps = 47/230 (20%)
Query: 18 WYTLTVPGDS---PCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQ 74
W L P S P GH+ + + V +++ GG P+ FS G +
Sbjct: 318 WELLAPPASSSSGPPGLAGHAAALVDDVW------LYVSGGRTPHDLFSS------GLFR 365
Query: 75 WDLDTCKGLL-----------PRYEHASFIPSCTPDRIWVFGGANQSGNR-----NCLQV 118
+ LD+ G P S + + V GG S R N ++
Sbjct: 366 FRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTEL 425
Query: 119 LNPETRTWTTPEVTS--PPPSPRTFHTSSAAIGNQLYVFGGGERG---AQPVQDTKLHVF 173
+ + WTT + P R FHT+S +GN + V+GG + + + +
Sbjct: 426 FHVDRHVWTTLKGRDGLQGPRERAFHTASV-LGNYMVVYGGNVHTHYQEEKCYEDGIFFY 484
Query: 174 DANTLTW---------SQPETLGNPPSPRHGHV-MVAAGTKLFIHGGLAG 213
W PE PPS R+ HV V G+ L + GG +G
Sbjct: 485 HLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSG 534
Score = 35.4 bits (80), Expect = 0.083
Identities = 33/136 (24%), Positives = 54/136 (39%), Gaps = 7/136 (5%)
Query: 25 GDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGL- 83
G P R H+ +Y+P A RG ++++GG D ++L QW +
Sbjct: 1493 GPGPSPRSFHAAAYVP----AGRGAMYLLGGLTAGGVTRDFWVLNLTTLQWRQEKAPQTV 1548
Query: 84 -LPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFH 142
LP + + V G + ++G L T TW + + PP+ H
Sbjct: 1549 ELPAVAGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGH 1608
Query: 143 TS-SAAIGNQLYVFGG 157
++ + LYVFGG
Sbjct: 1609 SAVYHEATDSLYVFGG 1624
>gi|62955044 F-box protein 42 [Homo sapiens]
Length = 717
Score = 55.5 bits (132), Expect = 8e-08
Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 14/149 (9%)
Query: 122 ETRTWTTPEVTSPPPSPRTFHTSSAAIGNQ-LYVFGGGERGAQPVQDTKLHVFDANTLTW 180
E+RT+ P P + R H++ NQ +YVFGG + + L D N+ W
Sbjct: 105 ESRTYPYP---GTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEW 161
Query: 181 SQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA---------GDRFYDDLHCIDISDMKWQ 231
+P G+ PSP+ G +V L + GG +RF+D++H S W
Sbjct: 162 IRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWN 221
Query: 232 KLNPTGAAPAGCAAHSAVAMGKHVYIFGG 260
+ T P A HS+ + + +FGG
Sbjct: 222 CIVTTHGPPP-MAGHSSCVIDDKMIVFGG 249
Score = 54.3 bits (129), Expect = 2e-07
Identities = 68/268 (25%), Positives = 100/268 (37%), Gaps = 37/268 (13%)
Query: 20 TLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANP---NRSFSDVHTMDLGKHQWD 76
T PG R HS Y +++ GG N +F+D+ +DL +W
Sbjct: 108 TYPYPGTPITQRFSHSACYYDA-----NQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWI 162
Query: 77 LDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPE-----------TRT 125
G P + + + D + +FGG + Q PE ++
Sbjct: 163 RPLASGSYPSPKAGATL-VVYKDLLVLFGGWTRPSPYPLHQ---PERFFDEIHTYSPSKN 218
Query: 126 WTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPET 185
W VT+ P P H SS I +++ VFGG Q D + V D WS+P
Sbjct: 219 WWNCIVTTHGPPPMAGH-SSCVIDDKMIVFGGSLGSRQMSND--VWVLDLEQWAWSKPNI 275
Query: 186 LGNPPSPRHGH-VMVAAGTKLFIHGGLAG-DRFYDDLHCIDI--SDMKWQKL----NPTG 237
G P PR G +V + I GG G + + D + + WQ L G
Sbjct: 276 SGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHG 335
Query: 238 AAPAGCAAHSAVAMGKHVYIFGGMTPAG 265
A C H A +G+ V +F P+G
Sbjct: 336 APELWC--HPACRVGQCVVVF-SQAPSG 360
Score = 53.9 bits (128), Expect = 2e-07
Identities = 58/234 (24%), Positives = 93/234 (39%), Gaps = 21/234 (8%)
Query: 71 GKHQWDLDTCK----GLLPRYEHASFIPSCTPDRIWVFGGANQSGNR---NCLQVLNPET 123
G QW+ T + R+ H++ ++VFGG QS N L L+ +
Sbjct: 100 GNIQWESRTYPYPGTPITQRFSHSACYYDANQS-MYVFGGCTQSSCNAAFNDLWRLDLNS 158
Query: 124 RTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGA-----QPVQD-TKLHVFDANT 177
+ W P + PSP+ T + L +FGG R + QP + ++H + +
Sbjct: 159 KEWIRPLASGSYPSPKAGATL-VVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSK 217
Query: 178 LTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDR-FYDDLHCIDISDMKWQKLNPT 236
W+ T PP P GH K+ + GG G R +D+ +D+ W K N +
Sbjct: 218 NWWNCIVTTHGPP-PMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNIS 276
Query: 237 GAAPAGCAAHSAVAM-GKHVYIFGGMTPAGAL---DTMYQYHTEEQHWTLLKFD 286
G +P S + + + I GG AL + H+ W LK +
Sbjct: 277 GPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVE 330
>gi|11545731 gigaxonin [Homo sapiens]
Length = 597
Score = 54.7 bits (130), Expect = 1e-07
Identities = 55/201 (27%), Positives = 81/201 (40%), Gaps = 20/201 (9%)
Query: 90 ASFIPSCTPDRIWVFGGANQSGNR-----NCLQVL-NPETRTWTTPEVTSPPPSPRTFHT 143
A+F P + I GG + + C+ L +P + W +P PR H
Sbjct: 264 ANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIE---LAPLSMPRINHG 320
Query: 144 SSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGT 203
+A G L+VFGG + Q + + + DANT T P RH +V
Sbjct: 321 VLSAEGF-LFVFGGQDENKQTLSSGEKYDPDANTWTALPPMN-----EARHNFGIVEIDG 374
Query: 204 KLFIHGGLAGDRFYDDLHCIDISDMKWQKL-NPTGAAPAGCAAHSAVAMGKHVYIFGGMT 262
L+I GG G++ + C DI W K + T GC A AM K +Y GG +
Sbjct: 375 MLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYA----AMKKKIYAMGGGS 430
Query: 263 PAGALDTMYQYHTEEQHWTLL 283
+++ Y Q WT +
Sbjct: 431 YGKLFESVECYDPRTQQWTAI 451
Score = 47.8 bits (112), Expect = 2e-05
Identities = 48/201 (23%), Positives = 79/201 (39%), Gaps = 25/201 (12%)
Query: 101 IWVFGGANQSGNRNCL---QVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG 157
++VFGG Q N+ L + +P+ TWT PP + + I LY+ GG
Sbjct: 328 LFVFGG--QDENKQTLSSGEKYDPDANTWTA----LPPMNEARHNFGIVEIDGMLYILGG 381
Query: 158 GERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFY 217
+ + + + +D + TW++ L R A K++ GG + + +
Sbjct: 382 EDGEKELIS---MECYDIYSKTWTKQPDL---TMVRKIGCYAAMKKKIYAMGGGSYGKLF 435
Query: 218 DDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGM-----TPAGALDTMYQ 272
+ + C D +W + P G A VAM +Y+FGG+ + T
Sbjct: 436 ESVECYDPRTQQWTAICPLKERRFGAVA-CGVAM--ELYVFGGVRSREDAQGSEMVTCKS 492
Query: 273 --YHTEEQHWTLLKFDTLLPP 291
YH E + W L L P
Sbjct: 493 EFYHDEFKRWIYLNDQNLCIP 513
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 53.9 bits (128), Expect = 2e-07
Identities = 56/207 (27%), Positives = 83/207 (40%), Gaps = 16/207 (7%)
Query: 100 RIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGE 159
+++ GG + + ++ NPE W P P P F ++A + QLYV GG
Sbjct: 243 KLYALGGRHNDVALDSVETYNPELNVWR-PAPALPAPC---FAHAAAILEGQLYVSGGCG 298
Query: 160 RGAQPVQDTKLHVFDANTLTWSQPETLGNPPS-PRHGHVMVAAGTKLFIHGGLAGDRFYD 218
Q + L +D +P T +P PR GHVM A G +L++ GGL
Sbjct: 299 GTGQYL--ASLMHYDPKL---EKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLL 353
Query: 219 DLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALD-TMYQYHTEE 277
++ W L P + G A SAV G+ + + G AL ++ Y
Sbjct: 354 SFEAYELRTDSWTHLAPLPSPHVGAA--SAVLQGELLVLGGYSHRTYALSHLIHAYCPGL 411
Query: 278 QHWTLLKFDTLLPPGRLDHSMCIIPWP 304
W L LP R + CI+ P
Sbjct: 412 GRWLCL---GTLPRPRAEMPACILTLP 435
Score = 37.7 bits (86), Expect = 0.017
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 177 TLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCI------DISDMKW 230
T+ W Q L P RHG +A G++L++ GG FY + + + S W
Sbjct: 167 TVEWGQLPALPAPGRFRHGAASLA-GSELYVCGG---QDFYSHSNTLASTLRWEPSQEDW 222
Query: 231 QKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 280
+++ P A + S VA+ +Y GG ALD++ Y+ E W
Sbjct: 223 EEMAPLSQARS---LFSLVALDGKLYALGGRHNDVALDSVETYNPELNVW 269
Score = 30.4 bits (67), Expect = 2.7
Identities = 17/55 (30%), Positives = 28/55 (50%)
Query: 304 PVTCASEKEDSNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGGMNT 358
P C +E DS+ L + E E +A ++ + ++ E A L C+ FG M+T
Sbjct: 35 PAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMST 89
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 53.9 bits (128), Expect = 2e-07
Identities = 48/199 (24%), Positives = 78/199 (39%), Gaps = 19/199 (9%)
Query: 88 EHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAA 147
EHA I+ G + + N ++ +P T +W P + + A
Sbjct: 388 EHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSW----AYVAPLKREVYAHAGAT 443
Query: 148 IGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFI 207
+ ++Y+ G RG +++T H +D + TW TL + P R H M KL++
Sbjct: 444 LEGKMYI-TCGRRGEDYLKET--HCYDPGSNTW---HTLADGPVRRAWHGMATLLNKLYV 497
Query: 208 HGGLAGDRFY-DDLH---CIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTP 263
GG D Y D+H C + +W + P PAG + +Y+ GG +
Sbjct: 498 IGGSNNDAGYRRDVHQVACYSCTSGQWSSVCP---LPAGHGEPGIAVLDNRIYVLGGRSH 554
Query: 264 AGALDTMYQ--YHTEEQHW 280
T Y Y E+ W
Sbjct: 555 NRGSRTGYVHIYDVEKDCW 573
Score = 33.1 bits (74), Expect = 0.41
Identities = 34/148 (22%), Positives = 59/148 (39%), Gaps = 9/148 (6%)
Query: 43 GNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIW 102
G GK++I G + H D G + W G + R H + ++++
Sbjct: 441 GATLEGKMYITCGRRGEDYLKETHCYDPGSNTWH-TLADGPVRRAWHGM---ATLLNKLY 496
Query: 103 VFGGA-NQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTF-HTSSAAIGNQLYVFGGGER 160
V GG+ N +G R V + T+ + +S P P A + N++YV GG
Sbjct: 497 VIGGSNNDAGYRR--DVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSH 554
Query: 161 GAQPVQDTKLHVFDANTLTWSQPETLGN 188
+ + +H++D W + L N
Sbjct: 555 N-RGSRTGYVHIYDVEKDCWEEGPQLDN 581
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 53.5 bits (127), Expect = 3e-07
Identities = 56/241 (23%), Positives = 98/241 (40%), Gaps = 28/241 (11%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLP----RYEHASFIPSCTPDRIWV 103
G++++VGG+N H+ DL + +P R + ++++
Sbjct: 415 GQLYVVGGSNG-------HSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYI 467
Query: 104 FGGAN---QSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGER 160
GG++ Q G +NC V +P T+ WT+ P + R ++ +G LY+ GG E
Sbjct: 468 VGGSDPYGQKGLKNC-DVFDPVTKLWTS----CAPLNIRRHQSAVCELGGYLYIIGGAES 522
Query: 161 GAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDL 220
+ + + + NT T P + R G + KLF+ GG G +
Sbjct: 523 W-NCLNTVERYNPENNTWTLIAPMNVA-----RRGAGVAVLNGKLFVCGGFDGSHAISCV 576
Query: 221 HCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 280
D + +W K+ +P A + V G +Y GG L+T+ Y+ E W
Sbjct: 577 EMYDPTRNEW-KMMGNMTSPRSNAGIATV--GNTIYAVGGFDGNEFLNTVEVYNLESNEW 633
Query: 281 T 281
+
Sbjct: 634 S 634
Score = 52.0 bits (123), Expect = 9e-07
Identities = 45/188 (23%), Positives = 78/188 (41%), Gaps = 16/188 (8%)
Query: 45 AKRGKVFIVGGANP--NRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIW 102
A GK++IVGG++P + + D W +C L R H S + ++
Sbjct: 460 ALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWT--SCAPLNIR-RHQSAVCELG-GYLY 515
Query: 103 VFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGA 162
+ GGA N ++ NPE TWT P + A + +L+V GG + G+
Sbjct: 516 IIGGAESWNCLNTVERYNPENNTWTL----IAPMNVARRGAGVAVLNGKLFVCGGFD-GS 570
Query: 163 QPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHC 222
+ ++ +D W +GN SPR + G ++ GG G+ F + +
Sbjct: 571 HAISCVEM--YDPTRNEWKM---MGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEV 625
Query: 223 IDISDMKW 230
++ +W
Sbjct: 626 YNLESNEW 633
Score = 50.1 bits (118), Expect = 3e-06
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 20/184 (10%)
Query: 105 GGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQP 164
GG N+ ++ NP T W+ +P +PR + +G QLYV GG +
Sbjct: 374 GGYNREECLRTVECYNPHTDHWS---FLAPMRTPRARFQMAVLMG-QLYVVGGSNGHSDD 429
Query: 165 VQDTKLHVFDANTLTWSQ-PETLGNPPSPRHGHVMVAAGTKLFIHGGLA--GDRFYDDLH 221
+ ++ +D+N W PE N R + A KL+I GG G + +
Sbjct: 430 LSCGEM--YDSNIDDWIPVPELRTN----RCNAGVCALNGKLYIVGGSDPYGQKGLKNCD 483
Query: 222 CIDISDMKWQKLNPTGAAPAGCAAHSAVA--MGKHVYIFGGMTPAGALDTMYQYHTEEQH 279
D W T AP H + +G ++YI GG L+T+ +Y+ E
Sbjct: 484 VFDPVTKLW-----TSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNT 538
Query: 280 WTLL 283
WTL+
Sbjct: 539 WTLI 542
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 52.8 bits (125), Expect = 5e-07
Identities = 52/236 (22%), Positives = 88/236 (37%), Gaps = 26/236 (11%)
Query: 50 VFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQ 109
+F +GG + + + D +W TC+ PR H + + +++ GG +
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGA---AYLKGYVYIIGGFDS 349
Query: 110 SGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTK 169
N ++ +P +TW P R + S +GN +Y GG + +
Sbjct: 350 VDYFNSVKRFDPVKKTWHQVA----PMHSRRCYVSVTVLGNFIYAMGGFDGYVR------ 399
Query: 170 LHVFDANTLTWSQPET-LGNPPSPRHGHVMVAAGT----KLFIHGGLAGDRFYDDLHCID 224
NT +PET +P H A+ T K++I GG G+ +
Sbjct: 400 -----LNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYN 454
Query: 225 ISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 280
+W + P + +G +A G+HVY GG A L + Y W
Sbjct: 455 TESNQWTVIAPMRSRRSGIGV---IAYGEHVYAVGGFDGANRLRSAEAYSPVANTW 507
Score = 42.0 bits (97), Expect = 9e-04
Identities = 43/184 (23%), Positives = 68/184 (36%), Gaps = 14/184 (7%)
Query: 101 IWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGER 160
++ GG + N ++ + W VT SPR +H +A + +Y+ GG +
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVN--VTCEEESPRAYH-GAAYLKGYVYIIGGFD- 348
Query: 161 GAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAA-GTKLFIHGGLAGDRFYDD 219
+ FD TW Q P R +V V G ++ GG G +
Sbjct: 349 --SVDYFNSVKRFDPVKKTWHQVA----PMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNT 402
Query: 220 LHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 279
+ +W + P + SA + VYI GG L T Y+TE
Sbjct: 403 AERYEPETNQWTLIAPMHEQRSDA---SATTLYGKVYICGGFNGNECLFTAEVYNTESNQ 459
Query: 280 WTLL 283
WT++
Sbjct: 460 WTVI 463
Score = 42.0 bits (97), Expect = 9e-04
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 25/201 (12%)
Query: 14 RKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKH 73
R W +T +SP R H +YL +G V+I+GG + F+ V D K
Sbjct: 314 RADRWVNVTCEEESP--RAYHGAAYL-------KGYVYIIGGFDSVDYFNSVKRFDPVKK 364
Query: 74 QWDLDTCKGLLPRYEHASFIP-SCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVT 132
W + P + ++ + + I+ GG + N + PET WT +
Sbjct: 365 TW-----HQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWT---LI 416
Query: 133 SPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSP 192
+P R+ S+ + ++Y+ GG G + + +++ ++N T P S
Sbjct: 417 APMHEQRS-DASATTLYGKVYIC-GGFNGNECLFTAEVYNTESNQWTVIAPMR-----SR 469
Query: 193 RHGHVMVAAGTKLFIHGGLAG 213
R G ++A G ++ GG G
Sbjct: 470 RSGIGVIAYGEHVYAVGGFDG 490
Score = 37.7 bits (86), Expect = 0.017
Identities = 34/154 (22%), Positives = 54/154 (35%), Gaps = 15/154 (9%)
Query: 130 EVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNP 189
+ T+P PR + AIG G G P + +DA W
Sbjct: 278 DFTNPLTRPRLPYAILFAIG--------GWSGGSPTN--AIEAYDARADRWVNVTCEEES 327
Query: 190 PSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAV 249
P HG + ++I GG +++ + D W ++ P + S
Sbjct: 328 PRAYHGAAYLKG--YVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYV---SVT 382
Query: 250 AMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLL 283
+G +Y GG L+T +Y E WTL+
Sbjct: 383 VLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLI 416
Score = 30.8 bits (68), Expect = 2.0
Identities = 25/111 (22%), Positives = 41/111 (36%), Gaps = 10/111 (9%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCT-PDRIWVFGG 106
GKV+I GG N N + +QW + + P S I + ++ GG
Sbjct: 433 GKVYICGGFNGNECLFTAEVYNTESNQWTV-----IAPMRSRRSGIGVIAYGEHVYAVGG 487
Query: 107 ANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG 157
+ + + +P TW T P S + + + L+V GG
Sbjct: 488 FDGANRLRSAEAYSPVANTWRTIPTMFNPRS----NFGIEVVDDLLFVVGG 534
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 52.8 bits (125), Expect = 5e-07
Identities = 54/229 (23%), Positives = 98/229 (42%), Gaps = 21/229 (9%)
Query: 30 ARVGHSCSYLPPVGNAKRGKVFIVG--GANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRY 87
AR GH + L G + G A+P+ S V D G ++W + L
Sbjct: 377 ARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM--VAPLRDGV 434
Query: 88 EHASFIPSCTPDRIWVFGGANQSGNR-NCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSA 146
+A+ + + +++VFGG + + + +Q +P WT + + P P + T++A
Sbjct: 435 SNAAVVSAKL--KLFVFGGTSIHRDMVSKVQCYDPSENRWT---IKAECPQPWRY-TAAA 488
Query: 147 AIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLF 206
+G+Q+++ GG + FD T W++ +G+ + R +A+G KL+
Sbjct: 489 VLGSQIFIMGGDTEFTA----ASAYRFDCETNQWTR---IGDMTAKRMSCHALASGNKLY 541
Query: 207 IHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHV 255
+ GG G + L C D + W N P + V+ KH+
Sbjct: 542 VVGGYFGTQRCKTLDCYDPTSDTW---NCITTVPYSLIPTAFVSTWKHL 587
Score = 31.6 bits (70), Expect = 1.2
Identities = 41/166 (24%), Positives = 67/166 (40%), Gaps = 18/166 (10%)
Query: 201 AGTKLFIHGG--LAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIF 258
AG L I GG D+ Y D K +++ P P+ SA A+G VY+
Sbjct: 293 AGHTLLILGGQTFMCDKIYQ-------VDHKAKEIIPKADLPSPRKEFSASAIGCKVYVT 345
Query: 259 GGM-TPAGALDTMYQYHTEEQHWTLLKFDTLLPPG----RLDHSMCIIPWPVTCASEKED 313
GG + G ++ Y T + W+ + G L++ + ++ + A
Sbjct: 346 GGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPA 405
Query: 314 SNSLTLNHEAEKEDSADKVMS----HSGDSHEESQTATLLCLVFGG 355
S S++L + + A+K M G S+ +A L VFGG
Sbjct: 406 SPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGG 451
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 51.6 bits (122), Expect = 1e-06
Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 16/184 (8%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWD-LDTCKGLLPRYEHASFIPSCTPDRIWVFGG 106
G +F VGG + + + + DL + W + G F + D+++V GG
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNG-----RRLQFGVAVLDDKLYVVGG 475
Query: 107 ANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQ 166
+ N ++ NP+T+TW+ PP S A + +Y GG + +
Sbjct: 476 RDGLKTLNTVECYNPKTKTWS----VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYL-- 529
Query: 167 DTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDIS 226
+ +D W+ T+ P S V V +G KL+ GG G + C D
Sbjct: 530 -NTVERWDPQARQWNFVATMSTPRST--VGVAVLSG-KLYAVGGRDGSSCLKSVECFDPH 585
Query: 227 DMKW 230
KW
Sbjct: 586 TNKW 589
Score = 33.5 bits (75), Expect = 0.32
Identities = 43/217 (19%), Positives = 74/217 (34%), Gaps = 22/217 (10%)
Query: 37 SYLPPVGNAKRG--------KVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYE 88
S +PP+ + G ++ VGG + + V D QW+ PR
Sbjct: 496 SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRST 554
Query: 89 HASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAI 148
+ S +++ GG + S ++ +P T WT S R
Sbjct: 555 VGVAVLS---GKLYAVGGRDGSSCLKSVECFDPHTNKWTL----CAQMSKRRGGVGVTTW 607
Query: 149 GNQLYVFGGGERGAQPVQDTK---LHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKL 205
LY GG + A + + +D T W+ ++ R + G KL
Sbjct: 608 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMS---ISRDAVGVCLLGDKL 664
Query: 206 FIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAG 242
+ GG G + + + D +W ++ P AG
Sbjct: 665 YAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 701
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 51.6 bits (122), Expect = 1e-06
Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 16/184 (8%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWD-LDTCKGLLPRYEHASFIPSCTPDRIWVFGG 106
G +F VGG + + + + DL + W + G F + D+++V GG
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNG-----RRLQFGVAVLDDKLYVVGG 460
Query: 107 ANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQ 166
+ N ++ NP+T+TW+ PP S A + +Y GG + +
Sbjct: 461 RDGLKTLNTVECYNPKTKTWS----VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYL-- 514
Query: 167 DTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDIS 226
+ +D W+ T+ P S V V +G KL+ GG G + C D
Sbjct: 515 -NTVERWDPQARQWNFVATMSTPRST--VGVAVLSG-KLYAVGGRDGSSCLKSVECFDPH 570
Query: 227 DMKW 230
KW
Sbjct: 571 TNKW 574
Score = 33.5 bits (75), Expect = 0.32
Identities = 43/217 (19%), Positives = 74/217 (34%), Gaps = 22/217 (10%)
Query: 37 SYLPPVGNAKRG--------KVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYE 88
S +PP+ + G ++ VGG + + V D QW+ PR
Sbjct: 481 SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRST 539
Query: 89 HASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAI 148
+ S +++ GG + S ++ +P T WT S R
Sbjct: 540 VGVAVLS---GKLYAVGGRDGSSCLKSVECFDPHTNKWTL----CAQMSKRRGGVGVTTW 592
Query: 149 GNQLYVFGGGERGAQPVQDTK---LHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKL 205
LY GG + A + + +D T W+ ++ R + G KL
Sbjct: 593 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMS---ISRDAVGVCLLGDKL 649
Query: 206 FIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAG 242
+ GG G + + + D +W ++ P AG
Sbjct: 650 YAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 686
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 51.6 bits (122), Expect = 1e-06
Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 16/184 (8%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWD-LDTCKGLLPRYEHASFIPSCTPDRIWVFGG 106
G +F VGG + + + + DL + W + G F + D+++V GG
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNG-----RRLQFGVAVLDDKLYVVGG 521
Query: 107 ANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQ 166
+ N ++ NP+T+TW+ PP S A + +Y GG + +
Sbjct: 522 RDGLKTLNTVECYNPKTKTWS----VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYL-- 575
Query: 167 DTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDIS 226
+ +D W+ T+ P S V V +G KL+ GG G + C D
Sbjct: 576 -NTVERWDPQARQWNFVATMSTPRST--VGVAVLSG-KLYAVGGRDGSSCLKSVECFDPH 631
Query: 227 DMKW 230
KW
Sbjct: 632 TNKW 635
Score = 33.5 bits (75), Expect = 0.32
Identities = 43/217 (19%), Positives = 74/217 (34%), Gaps = 22/217 (10%)
Query: 37 SYLPPVGNAKRG--------KVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYE 88
S +PP+ + G ++ VGG + + V D QW+ PR
Sbjct: 542 SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRST 600
Query: 89 HASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAI 148
+ S +++ GG + S ++ +P T WT S R
Sbjct: 601 VGVAVLS---GKLYAVGGRDGSSCLKSVECFDPHTNKWTL----CAQMSKRRGGVGVTTW 653
Query: 149 GNQLYVFGGGERGAQPVQDTK---LHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKL 205
LY GG + A + + +D T W+ ++ R + G KL
Sbjct: 654 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMS---ISRDAVGVCLLGDKL 710
Query: 206 FIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAG 242
+ GG G + + + D +W ++ P AG
Sbjct: 711 YAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 747
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 51.2 bits (121), Expect = 1e-06
Identities = 73/290 (25%), Positives = 118/290 (40%), Gaps = 43/290 (14%)
Query: 15 KATWYTLTV-PGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGA---NPNRSFSDVHTMDL 70
K TW LT+ P +S H C + V N +F++GG NPN S T +
Sbjct: 349 KKTWKILTIMPYNS-----AHHC--VVEVENF----LFVLGGEDQWNPNGKHS---TNFV 394
Query: 71 GKHQWDLDTCKGLLPRYEHASFIPSCTPDR-IWVFGGANQSGNRNCLQVLNPETRTWTTP 129
++ ++ L P E + +C D+ ++V GG N++G + ++ N ET W
Sbjct: 395 SRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEW--- 451
Query: 130 EVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNP 189
S P P H + A ++Y+ GG G L+ +D W++ + +
Sbjct: 452 RYVSSLPQPLAAH-AGAVHNGKIYISGGVHNGEYV---PWLYCYDPVMDVWARKQDMN-- 505
Query: 190 PSPRHGHVMVAAGTKLFIHGG--LAGDRFYDDL--HCIDISDMKWQKLNP---TGAAPAG 242
+ R H + +L+ GG L G D + C D +W L G + G
Sbjct: 506 -TKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPG 564
Query: 243 CAAHSAVAMGKHVYIFGGMT-PAGAL-DTMYQYHTEEQHWTLLKFDTLLP 290
CA + +Y+ GG + GA + Y E+ WT L+ D P
Sbjct: 565 CA-----VLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEP 609
Score = 32.3 bits (72), Expect = 0.70
Identities = 32/134 (23%), Positives = 49/134 (36%), Gaps = 11/134 (8%)
Query: 152 LYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGL 211
L + GG G + + +D TW + L P H +V LF+ GG
Sbjct: 324 LLLVGGLPPGPDRLPSNLVQYYDDEKKTW---KILTIMPYNSAHHCVVEVENFLFVLGGE 380
Query: 212 A-----GDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGA 266
G + + D W +L P A + A + KH+Y+ GG G
Sbjct: 381 DQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRA---SFYACRLDKHLYVIGGRNETGY 437
Query: 267 LDTMYQYHTEEQHW 280
L ++ Y+ E W
Sbjct: 438 LSSVECYNLETNEW 451
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 49.7 bits (117), Expect = 4e-06
Identities = 57/237 (24%), Positives = 101/237 (42%), Gaps = 37/237 (15%)
Query: 30 ARVGHSCSYLPPVGNAKRGKVFIVGG---------ANPNRSFSDVHTMDLGKHQWDLDTC 80
AR GH + L + +++VGG A+P+ S V D ++W +
Sbjct: 377 ARFGHGSAEL-------KHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTM--- 426
Query: 81 KGLLPRYEHASFIPSCTPD-RIWVFGGANQSGNR-NCLQVLNPETRTWTTPEVTSPPPSP 138
+ P E S + +++ FGG + S ++ +Q + WT P T P P
Sbjct: 427 --VAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVP-ATCPQPWR 483
Query: 139 RTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVM 198
+T++A +GNQ+++ GG + + F++ T W++ +G+ + R
Sbjct: 484 ---YTAAAVLGNQIFIMGGDTEFSA----CSAYKFNSETYQWTK---VGDVTAKRMSCHA 533
Query: 199 VAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHV 255
VA+G KL++ GG G + L C D + W N P + V+ KH+
Sbjct: 534 VASGNKLYVVGGYFGIQRCKTLDCYDPTLDVW---NSITTVPYSLIPTAFVSTWKHL 587
Score = 29.6 bits (65), Expect = 4.6
Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 10/83 (12%)
Query: 202 GTKLFIHGG--LAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFG 259
G LF+ GG D+ Y + D K +++ P P+ SA A+G VYI G
Sbjct: 294 GHALFLLGGQTFMCDKLY-------LVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITG 346
Query: 260 GM-TPAGALDTMYQYHTEEQHWT 281
G + G ++ Y T + W+
Sbjct: 347 GRGSENGVSKDVWVYDTLHEEWS 369
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 48.9 bits (115), Expect = 7e-06
Identities = 47/189 (24%), Positives = 72/189 (38%), Gaps = 21/189 (11%)
Query: 85 PRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQV-----LNPETRTWTTPEVTSPPPSPR 139
PRY+H + + ++V GG + + V +P W +V S
Sbjct: 378 PRYQHGIAVIG---NFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWM--QVASLNEKRT 432
Query: 140 TFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMV 199
FH S A+ LY GG R A T + ++ T W+ + P +GH
Sbjct: 433 FFHLS--ALKGYLYAVGG--RNAAGELPT-VECYNPRTNEWTYVAKMSEP---HYGHAGT 484
Query: 200 AAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFG 259
G ++I GG+ D F +L C D KW + P H +G+ +Y+ G
Sbjct: 485 VYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVR---GLHCMCTVGERLYVIG 541
Query: 260 GMTPAGALD 268
G G D
Sbjct: 542 GNHFRGTSD 550
Score = 37.0 bits (84), Expect = 0.029
Identities = 32/130 (24%), Positives = 51/130 (39%), Gaps = 11/130 (8%)
Query: 157 GGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA---- 212
GG Q V +L ++D W ++L +PR+ H + G L++ GG +
Sbjct: 346 GGVLRQQLVVSKELRMYDEKAHEW---KSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 402
Query: 213 -GDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMY 271
G D + D KW ++ H + G ++Y GG AG L T+
Sbjct: 403 KGKTAVDTVFRFDPRYNKWMQVASLNEKRT--FFHLSALKG-YLYAVGGRNAAGELPTVE 459
Query: 272 QYHTEEQHWT 281
Y+ WT
Sbjct: 460 CYNPRTNEWT 469
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 48.9 bits (115), Expect = 7e-06
Identities = 44/189 (23%), Positives = 69/189 (36%), Gaps = 21/189 (11%)
Query: 85 PRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQV-----LNPETRTWTTPEVTSPPPSPR 139
PRY+H + + ++V GG + + V +P W +V S
Sbjct: 336 PRYQHGIAVIG---NFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWM--QVASLNEKRT 390
Query: 140 TFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMV 199
FH S A+ LY GG + + ++ WS + P +GH
Sbjct: 391 FFHLS--ALKGHLYAVGGRSAAGELAT---VECYNPRMNEWSYVAKMSEP---HYGHAGT 442
Query: 200 AAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFG 259
G ++I GG+ D F ++L C D KW + P H +G +Y+ G
Sbjct: 443 VYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVR---GLHCMCTVGDKLYVIG 499
Query: 260 GMTPAGALD 268
G G D
Sbjct: 500 GNHFRGTSD 508
Score = 37.4 bits (85), Expect = 0.022
Identities = 32/130 (24%), Positives = 51/130 (39%), Gaps = 11/130 (8%)
Query: 157 GGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA---- 212
GG Q V +L ++D W +L +PR+ H + G L++ GG +
Sbjct: 304 GGVLRQQLVVSKELRMYDERAQEW---RSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 360
Query: 213 -GDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMY 271
G D + D KW ++ H + G H+Y GG + AG L T+
Sbjct: 361 KGKTAVDTVFRFDPRYNKWMQVASLNEKRT--FFHLSALKG-HLYAVGGRSAAGELATVE 417
Query: 272 QYHTEEQHWT 281
Y+ W+
Sbjct: 418 CYNPRMNEWS 427
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/151 (21%), Positives = 61/151 (40%), Gaps = 9/151 (5%)
Query: 134 PPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPR 193
P + R H ++ ++Y GG + + +FD T W ++ + R
Sbjct: 350 PEMNSRRRHVGVISVEGKVYAVGGHDGNEHL---GSMEMFDPLTNKWMMKASMN---TKR 403
Query: 194 HGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGK 253
G + + G ++ GGL + ++D+ DI +W + P G +VA+
Sbjct: 404 RGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGV---GSVALVN 460
Query: 254 HVYIFGGMTPAGALDTMYQYHTEEQHWTLLK 284
HVY GG +L ++ +Y W +K
Sbjct: 461 HVYAVGGNDGMASLSSVERYDPHLDKWIEVK 491
Score = 40.4 bits (93), Expect = 0.003
Identities = 53/264 (20%), Positives = 98/264 (37%), Gaps = 26/264 (9%)
Query: 29 CARVGHSCSYLPPVGNAKR---------GKVFIVGGANPNRSFSDVHTMDLGKHQWDLDT 79
C + + + P N++R GKV+ VGG + N + D ++W +
Sbjct: 338 CYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKA 397
Query: 80 CKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPR 139
R + I+ GG + + N ++ + E+ W+T +P +PR
Sbjct: 398 SMNTKRR----GIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWST---VAPMNTPR 450
Query: 140 TFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMV 199
S A+ N +Y GG + A + + +D + W + + +G R G+ +
Sbjct: 451 G-GVGSVALVNHVYAVGGNDGMASL---SSVERYDPHLDKWIEVKEMG---QRRAGNGVS 503
Query: 200 AAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFG 259
L++ GG + + D KW + G A MGK ++ G
Sbjct: 504 KLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGI--ATVMGK-IFAVG 560
Query: 260 GMTPAGALDTMYQYHTEEQHWTLL 283
G L+T+ + W L+
Sbjct: 561 GHNGNAYLNTVEAFDPVLNRWELV 584
Score = 38.5 bits (88), Expect = 0.010
Identities = 38/196 (19%), Positives = 75/196 (38%), Gaps = 16/196 (8%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPS-CTPDRIWVFGG 106
G ++ +GG + N F+DV D+ QW + P + S + ++ GG
Sbjct: 413 GPIYAIGGLDDNTCFNDVERYDIESDQWST-----VAPMNTPRGGVGSVALVNHVYAVGG 467
Query: 107 ANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQ 166
+ + + ++ +P W + R + + LYV GG + + P+
Sbjct: 468 NDGMASLSSVERYDPHLDKW----IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNS-PL- 521
Query: 167 DTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDIS 226
+ + +D + W L +PR G + K+F GG G+ + + + D
Sbjct: 522 -SSVERYDPRSNKWDYVAAL---TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 577
Query: 227 DMKWQKLNPTGAAPAG 242
+W+ + AG
Sbjct: 578 LNRWELVGSVSHCRAG 593
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/237 (22%), Positives = 92/237 (38%), Gaps = 24/237 (10%)
Query: 50 VFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQ 109
+++ GG + +DV W+L + +PR H S + +I+ GG
Sbjct: 638 IYLSGGMESGVTLADVWCYMSLLDNWNL-VSRMTVPRCRHNSLVYD---GKIYTLGGLGV 693
Query: 110 SGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAI-GNQLYVFGGGERGAQPVQDT 168
+GN + ++ + T W + P P+ H+++A + G ++YVFGG +
Sbjct: 694 AGNVDHVERYDTITNQWE-----AVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVL 748
Query: 169 KLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDM 228
+ +V NT ++ + + N +P V +FI GG I D
Sbjct: 749 QSYVPQTNTWSFIESPMIDNKYAP-----AVTLNGFVFILGGAYA-------RATTIYDP 796
Query: 229 KWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGM--TPAGALDTMYQYHTEEQHWTLL 283
+ + SAV + +Y GG+ + AL M Y WTLL
Sbjct: 797 EKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLL 853
Score = 43.9 bits (102), Expect = 2e-04
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 9/121 (7%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGA 107
GK++ +GG + V D +QW+ LP+ H++ C +I+VFGG
Sbjct: 683 GKIYTLGGLGVAGNVDHVERYDTITNQWE---AVAPLPKAVHSAAATVC-GGKIYVFGGV 738
Query: 108 NQSGN-RNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQ 166
N++G LQ P+T TW+ E P + + + +++ GG A +
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIE----SPMIDNKYAPAVTLNGFVFILGGAYARATTIY 794
Query: 167 D 167
D
Sbjct: 795 D 795
Score = 42.0 bits (97), Expect = 9e-04
Identities = 45/170 (26%), Positives = 71/170 (41%), Gaps = 21/170 (12%)
Query: 120 NPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTL- 178
NP+ W + S P R F + +A G+ +Y+ GG E G T V+ +L
Sbjct: 609 NPQNNKWYP--LASLPFYDREFFSVVSA-GDNIYLSGGMESGV-----TLADVWCYMSLL 660
Query: 179 -TWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTG 237
W+ + PR H + K++ GGL D + D +W+ +
Sbjct: 661 DNWN---LVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAV---- 713
Query: 238 AAPAGCAAHSAVAM--GKHVYIFGGMTPAG-ALDTMYQYHTEEQHWTLLK 284
AP A HSA A G +Y+FGG+ AG A + Y + W+ ++
Sbjct: 714 -APLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIE 762
Score = 38.9 bits (89), Expect = 0.008
Identities = 38/167 (22%), Positives = 64/167 (38%), Gaps = 6/167 (3%)
Query: 115 CLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGER-GAQPVQDTKLHVF 173
C ++N R P +PRT SA + + + GG + G + +
Sbjct: 549 CRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCW 608
Query: 174 DANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKL 233
+ W +L P R +V+AG +++ GG+ D+ C W +
Sbjct: 609 NPQNNKWYPLASL--PFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 234 NPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 280
+ C +S V GK +Y GG+ AG +D + +Y T W
Sbjct: 667 SRMTVPR--CRHNSLVYDGK-IYTLGGLGVAGNVDHVERYDTITNQW 710
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/237 (22%), Positives = 92/237 (38%), Gaps = 24/237 (10%)
Query: 50 VFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQ 109
+++ GG + +DV W+L + +PR H S + +I+ GG
Sbjct: 638 IYLSGGMESGVTLADVWCYMSLLDNWNL-VSRMTVPRCRHNSLVYD---GKIYTLGGLGV 693
Query: 110 SGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAI-GNQLYVFGGGERGAQPVQDT 168
+GN + ++ + T W + P P+ H+++A + G ++YVFGG +
Sbjct: 694 AGNVDHVERYDTITNQWE-----AVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVL 748
Query: 169 KLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDM 228
+ +V NT ++ + + N +P V +FI GG I D
Sbjct: 749 QSYVPQTNTWSFIESPMIDNKYAP-----AVTLNGFVFILGGAYA-------RATTIYDP 796
Query: 229 KWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGM--TPAGALDTMYQYHTEEQHWTLL 283
+ + SAV + +Y GG+ + AL M Y WTLL
Sbjct: 797 EKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLL 853
Score = 43.9 bits (102), Expect = 2e-04
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 9/121 (7%)
Query: 48 GKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGA 107
GK++ +GG + V D +QW+ LP+ H++ C +I+VFGG
Sbjct: 683 GKIYTLGGLGVAGNVDHVERYDTITNQWE---AVAPLPKAVHSAAATVC-GGKIYVFGGV 738
Query: 108 NQSGN-RNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQ 166
N++G LQ P+T TW+ E P + + + +++ GG A +
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIE----SPMIDNKYAPAVTLNGFVFILGGAYARATTIY 794
Query: 167 D 167
D
Sbjct: 795 D 795
Score = 42.0 bits (97), Expect = 9e-04
Identities = 45/170 (26%), Positives = 71/170 (41%), Gaps = 21/170 (12%)
Query: 120 NPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTL- 178
NP+ W + S P R F + +A G+ +Y+ GG E G T V+ +L
Sbjct: 609 NPQNNKWYP--LASLPFYDREFFSVVSA-GDNIYLSGGMESGV-----TLADVWCYMSLL 660
Query: 179 -TWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTG 237
W+ + PR H + K++ GGL D + D +W+ +
Sbjct: 661 DNWN---LVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAV---- 713
Query: 238 AAPAGCAAHSAVAM--GKHVYIFGGMTPAG-ALDTMYQYHTEEQHWTLLK 284
AP A HSA A G +Y+FGG+ AG A + Y + W+ ++
Sbjct: 714 -APLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIE 762
Score = 38.9 bits (89), Expect = 0.008
Identities = 38/167 (22%), Positives = 64/167 (38%), Gaps = 6/167 (3%)
Query: 115 CLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGER-GAQPVQDTKLHVF 173
C ++N R P +PRT SA + + + GG + G + +
Sbjct: 549 CRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCW 608
Query: 174 DANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKL 233
+ W +L P R +V+AG +++ GG+ D+ C W +
Sbjct: 609 NPQNNKWYPLASL--PFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 234 NPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 280
+ C +S V GK +Y GG+ AG +D + +Y T W
Sbjct: 667 SRMTVPR--CRHNSLVYDGK-IYTLGGLGVAGNVDHVERYDTITNQW 710
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 47.4 bits (111), Expect = 2e-05
Identities = 54/218 (24%), Positives = 86/218 (39%), Gaps = 23/218 (10%)
Query: 100 RIWVFGGANQSGNRNCL-QVLNPETRTWTTPEVTSPPPSPRTFHTSSAAI--GNQLYVFG 156
+I+ GG+ + L + + T +W T PS T S + +YV G
Sbjct: 383 KIYTSGGSEVGNSALYLFECYDTRTESWHTK------PSMLTQRCSHGMVEANGLIYVCG 436
Query: 157 G--GERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGD 214
G G + V ++ V+D T TW++ L R H +V K+F GG G
Sbjct: 437 GSLGNNVSGRVLNS-CEVYDPATETWTE---LCPMIEARKNHGLVFVKDKIFAVGGQNGL 492
Query: 215 RFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYH 274
D++ DI +W+ ++P P A+G VY+ G G L + +Y+
Sbjct: 493 GGLDNVEYYDIKLNEWKMVSPM---PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 549
Query: 275 TEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKE 312
TE W P + C+I TC + +E
Sbjct: 550 TETDKWVANSKVRAFPV-----TSCLICVVDTCGANEE 582
Score = 31.6 bits (70), Expect = 1.2
Identities = 44/189 (23%), Positives = 68/189 (35%), Gaps = 23/189 (12%)
Query: 100 RIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGE 159
RI +FGG+ R NP+ +WT P + + N +Y+ GG +
Sbjct: 294 RIALFGGSQPQSCR----YFNPKDYSWTDIRC----PFEKRRDAACVFWDNVVYILGGSQ 345
Query: 160 RGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGL-AGDRFYD 218
P++ + N + S LG PP+PR AA K++ GG G+
Sbjct: 346 --LFPIKRMDCY----NVVKDSWYSKLG-PPTPRDSLAACAAEGKIYTSGGSEVGNSALY 398
Query: 219 DLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGM----TPAGALDTMYQYH 274
C D W P+ +H V +Y+ GG L++ Y
Sbjct: 399 LFECYDTRTESWH-TKPSMLTQR--CSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYD 455
Query: 275 TEEQHWTLL 283
+ WT L
Sbjct: 456 PATETWTEL 464
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 47.4 bits (111), Expect = 2e-05
Identities = 54/218 (24%), Positives = 86/218 (39%), Gaps = 23/218 (10%)
Query: 100 RIWVFGGANQSGNRNCL-QVLNPETRTWTTPEVTSPPPSPRTFHTSSAAI--GNQLYVFG 156
+I+ GG+ + L + + T +W T PS T S + +YV G
Sbjct: 361 KIYTSGGSEVGNSALYLFECYDTRTESWHTK------PSMLTQRCSHGMVEANGLIYVCG 414
Query: 157 G--GERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGD 214
G G + V ++ V+D T TW++ L R H +V K+F GG G
Sbjct: 415 GSLGNNVSGRVLNS-CEVYDPATETWTE---LCPMIEARKNHGLVFVKDKIFAVGGQNGL 470
Query: 215 RFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYH 274
D++ DI +W+ ++P P A+G VY+ G G L + +Y+
Sbjct: 471 GGLDNVEYYDIKLNEWKMVSPM---PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 527
Query: 275 TEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKE 312
TE W P + C+I TC + +E
Sbjct: 528 TETDKWVANSKVRAFPV-----TSCLICVVDTCGANEE 560
Score = 31.6 bits (70), Expect = 1.2
Identities = 44/189 (23%), Positives = 68/189 (35%), Gaps = 23/189 (12%)
Query: 100 RIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGE 159
RI +FGG+ R NP+ +WT P + + N +Y+ GG +
Sbjct: 272 RIALFGGSQPQSCR----YFNPKDYSWTDIRC----PFEKRRDAACVFWDNVVYILGGSQ 323
Query: 160 RGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGL-AGDRFYD 218
P++ + N + S LG PP+PR AA K++ GG G+
Sbjct: 324 --LFPIKRMDCY----NVVKDSWYSKLG-PPTPRDSLAACAAEGKIYTSGGSEVGNSALY 376
Query: 219 DLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGM----TPAGALDTMYQYH 274
C D W P+ +H V +Y+ GG L++ Y
Sbjct: 377 LFECYDTRTESWH-TKPSMLTQR--CSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYD 433
Query: 275 TEEQHWTLL 283
+ WT L
Sbjct: 434 PATETWTEL 442
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,027,855
Number of Sequences: 37866
Number of extensions: 933874
Number of successful extensions: 2895
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 2500
Number of HSP's gapped (non-prelim): 241
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.