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Search of human proteins with 33667063
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
(1059 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 2182 0.0
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 277 3e-74
gi|11415040 matriptase [Homo sapiens] 277 4e-74
gi|58218970 protease, serine, 36 [Homo sapiens] 241 2e-63
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 234 2e-61
gi|40254871 transmembrane protease, serine 11E [Homo sapiens] 218 2e-56
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens] 218 2e-56
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 213 8e-55
gi|87196600 polyserase 3 [Homo sapiens] 210 7e-54
gi|13994276 marapsin [Homo sapiens] 204 4e-52
gi|29244926 corin [Homo sapiens] 197 6e-50
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 195 2e-49
gi|223942069 enterokinase precursor [Homo sapiens] 194 4e-49
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 194 5e-49
gi|4506153 prostasin preproprotein [Homo sapiens] 193 6e-49
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 192 1e-48
gi|33695155 hepsin [Homo sapiens] 192 2e-48
gi|4504481 hepsin [Homo sapiens] 192 2e-48
gi|117956391 protease, serine, 33 [Homo sapiens] 192 2e-48
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 191 3e-48
gi|148613878 acrosin precursor [Homo sapiens] 191 4e-48
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 189 9e-48
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 189 9e-48
gi|11545839 protease, serine, 22 [Homo sapiens] 189 9e-48
gi|110815798 ovochymase 1 [Homo sapiens] 189 1e-47
gi|194018492 transmembrane protease, serine 11F [Homo sapiens] 186 1e-46
gi|21614531 testisin isoform 2 [Homo sapiens] 184 4e-46
gi|5803197 testisin isoform 1 [Homo sapiens] 184 5e-46
gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 182 2e-45
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens] 178 2e-44
>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
Length = 1059
Score = 2182 bits (5653), Expect = 0.0
Identities = 1059/1059 (100%), Positives = 1059/1059 (100%)
Query: 1 MEPTVADVHLVPRTTKEVPALDAACCRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHT 60
MEPTVADVHLVPRTTKEVPALDAACCRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHT
Sbjct: 1 MEPTVADVHLVPRTTKEVPALDAACCRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHT 60
Query: 61 AELRGIRWTSSLRRETSDYHRTLTPTLEALLHFLLRPLQTLSLGLEEELLQRGIRARLRE 120
AELRGIRWTSSLRRETSDYHRTLTPTLEALLHFLLRPLQTLSLGLEEELLQRGIRARLRE
Sbjct: 61 AELRGIRWTSSLRRETSDYHRTLTPTLEALLHFLLRPLQTLSLGLEEELLQRGIRARLRE 120
Query: 121 HGISLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDC 180
HGISLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDC
Sbjct: 121 HGISLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDC 180
Query: 181 SDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVS 240
SDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVS
Sbjct: 181 SDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVS 240
Query: 241 AAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTS 300
AAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTS
Sbjct: 241 AAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTS 300
Query: 301 PLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS 360
PLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS
Sbjct: 301 PLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS 360
Query: 361 LYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGV 420
LYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGV
Sbjct: 361 LYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGV 420
Query: 421 YARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVP 480
YARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVP
Sbjct: 421 YARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVP 480
Query: 481 LDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLL 540
LDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLL
Sbjct: 481 LDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLL 540
Query: 541 SAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELAS 600
SAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELAS
Sbjct: 541 SAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELAS 600
Query: 601 PLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV 660
PLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV
Sbjct: 601 PLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV 660
Query: 661 LYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGV 720
LYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGV
Sbjct: 661 LYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGV 720
Query: 721 YTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRV 780
YTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRV
Sbjct: 721 YTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRV 780
Query: 781 TGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPW 840
TGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPW
Sbjct: 781 TGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPW 840
Query: 841 QVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVAR 900
QVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVAR
Sbjct: 841 QVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVAR 900
Query: 901 IYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREG 960
IYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREG
Sbjct: 901 IYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREG 960
Query: 961 GSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSG 1020
GSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSG
Sbjct: 961 GSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSG 1020
Query: 1021 RWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE 1059
RWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE
Sbjct: 1021 RWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE 1059
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 277 bits (709), Expect = 3e-74
Identities = 131/285 (45%), Positives = 179/285 (62%), Gaps = 6/285 (2%)
Query: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGGMEASPGE 213
C +F C + CV K NP+CD + DC DGSDE HC+CGLQ + RIVGG +S GE
Sbjct: 531 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGP---SSRIVGGAVSSEGE 587
Query: 214 FPWQASLRENKEHFCGAAIINARWLVSAAHCFNE--FQDPTKWVAYVGATYLSGSEASTV 271
+PWQASL+ H CG A+I RW+++AAHCF E W ++G + + V
Sbjct: 588 WPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEV 647
Query: 272 RAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGW 331
+V +++ HP + D+ D+DVA+L+L P+ ++PVCLPA +H F P C I+GW
Sbjct: 648 SFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGW 707
Query: 332 GYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPL 391
G L+E + LQK V+L+ Q LC+ +Y + +T RM+CAGY GK D+CQGDSGGPL
Sbjct: 708 GALREGGPIS-NALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPL 766
Query: 392 VCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATT 436
VC+ SGR+FLAG+VSWG+GC GVY R+T + WI + T
Sbjct: 767 VCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT 811
Score = 238 bits (606), Expect = 3e-62
Identities = 117/244 (47%), Positives = 158/244 (64%), Gaps = 6/244 (2%)
Query: 816 DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCF--DVY 873
DCGL + +RIVGG+ + GEWPWQ SL +R R H CG L+A+RW+++AAHCF D
Sbjct: 567 DCGLQGPS-SRIVGGAVSSEGEWPWQASLQVRGR-HICGGALIADRWVITAAHCFQEDSM 624
Query: 874 GDPKQWAAFLGTPFLSGA-EGQLE-RVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLV 931
W FLG + + G++ +V+R+ HP++ + DYDVALL+L PV RS V
Sbjct: 625 ASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAV 684
Query: 932 RPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSR 991
RP+CLP + G C ITGWG++REGG ++ LQK V+L+ + C Y Q++ R
Sbjct: 685 RPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVTPR 744
Query: 992 MLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRG 1051
MLCAG+ +G D+C GD+GGPL C+ SGRW L G+ SWG GCGRP++ GVYTR+ V
Sbjct: 745 MLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVIS 804
Query: 1052 WIGQ 1055
WI Q
Sbjct: 805 WIQQ 808
Score = 201 bits (511), Expect = 3e-51
Identities = 97/238 (40%), Positives = 141/238 (59%), Gaps = 4/238 (1%)
Query: 502 TRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQV---RAHL 558
+R+VGG ++ GE PWQ SL+ RH CG ++ DRW+++AAHCF + L
Sbjct: 575 SRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFL 634
Query: 559 GTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQ 618
G V + R++LHP + D+D+A+L+L P+ + ++PVCLP
Sbjct: 635 GKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSH 694
Query: 619 KFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEG 678
F G C I+GWG +EG LQK V +I Q CS +Y + +T RM+CAG+ +G
Sbjct: 695 FFEPGLHCWITGWGALREGGPIS-NALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKG 753
Query: 679 KVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMS 736
K D+CQGDSGGPL C+ G ++LAG+VSWG+GC + GVYTRIT + WI ++++
Sbjct: 754 KKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT 811
Score = 37.0 bits (84), Expect = 0.099
Identities = 17/42 (40%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 150 KSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCEC 191
+S CPG N CV P CD +DC +G DE +C C
Sbjct: 454 QSDPCPGEFLCSVNGLCV----PACDGVKDCPNGLDERNCVC 491
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 277 bits (708), Expect = 4e-74
Identities = 132/289 (45%), Positives = 185/289 (64%), Gaps = 9/289 (3%)
Query: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGGMEASPGE 213
C +++ C N C++K NPECD +EDCSDGSDE C+CGL+ R A R+VGG +A GE
Sbjct: 567 CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQA-RVVGGTDADEGE 625
Query: 214 FPWQASLRE-NKEHFCGAAIINARWLVSAAHCFNE-----FQDPTKWVAYVGATYLSGSE 267
+PWQ SL + H CGA++I+ WLVSAAHC+ + + DPT+W A++G S
Sbjct: 626 WPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRS 685
Query: 268 ASTVRAQ-VVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKC 326
A V+ + + +I+ HP +N T D+D+A+LEL P + ++P+CLP A+H+FP K
Sbjct: 686 APGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAI 745
Query: 327 LISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGD 386
++GWG+ + +LQK + +++Q C +L +T RM+C G+L G VDSCQGD
Sbjct: 746 WVTGWGHTQYGG-TGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGD 804
Query: 387 SGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEAT 435
SGGPL E GR F AG+VSWG GCA+ +PGVY R+ RDWI E T
Sbjct: 805 SGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENT 853
Score = 235 bits (600), Expect = 1e-61
Identities = 122/250 (48%), Positives = 153/250 (61%), Gaps = 9/250 (3%)
Query: 816 DCGLAP-AALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV-- 872
DCGL R+VGG+ A GEWPWQVSL + H CGA L++ WL+SAAHC+
Sbjct: 603 DCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDR 662
Query: 873 ---YGDPKQWAAFLGTPFLS--GAEG-QLERVARIYKHPFYNLYTLDYDVALLELAGPVR 926
Y DP QW AFLG S A G Q R+ RI HPF+N +T DYD+ALLEL P
Sbjct: 663 GFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAE 722
Query: 927 RSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPV 986
S +VRPICLP+ + P G +TGWG + GG+ A LQK +R++++ TC P
Sbjct: 723 YSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQ 782
Query: 987 QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRV 1046
QI+ RM+C GF GGVDSC GD+GGPL+ E GR GV SWG GC + + PGVYTR+
Sbjct: 783 QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRL 842
Query: 1047 AAVRGWIGQH 1056
R WI ++
Sbjct: 843 PLFRDWIKEN 852
Score = 214 bits (546), Expect = 3e-55
Identities = 113/251 (45%), Positives = 150/251 (59%), Gaps = 10/251 (3%)
Query: 491 ECGARPAMEKPTRVVGGFGAASGEVPWQVSLKE-GSRHFCGATVVGDRWLLSAAHC---- 545
+CG R + + RVVGG A GE PWQVSL G H CGA+++ WL+SAAHC
Sbjct: 603 DCGLR-SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDD 661
Query: 546 --FNHTKVEQVRAHLGTASLLGLGGSPVKIG-LRRVVLHPLYNPGILDFDLAVLELASPL 602
F ++ Q A LG V+ L+R++ HP +N D+D+A+LEL P
Sbjct: 662 RGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPA 721
Query: 603 AFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLY 662
++ ++P+CLP A FP G+ ++GWG+TQ G T +LQK + +I+Q TC L
Sbjct: 722 EYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGG-TGALILQKGEIRVINQTTCENLL 780
Query: 663 NFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYT 722
+T RM+C GFL G VDSCQGDSGGPL+ EA G + AG+VSWG GCAQ KPGVYT
Sbjct: 781 PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT 840
Query: 723 RITRLKGWILE 733
R+ + WI E
Sbjct: 841 RLPLFRDWIKE 851
Score = 39.7 bits (91), Expect = 0.015
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 151 SGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCEC 191
S CPG F+C +C+ K CD DC+D SDE +C C
Sbjct: 450 SDPCPGQ-FTCRTGRCIRK-ELRCDGWADCTDHSDELNCSC 488
Score = 34.3 bits (77), Expect = 0.64
Identities = 16/39 (41%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 156 GNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQ 194
G+ F+C N C + CD DC D SDE C C Q
Sbjct: 491 GHQFTCKNKFC-KPLFWVCDSVNDCGDNSDEQGCSCPAQ 528
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 241 bits (616), Expect = 2e-63
Identities = 187/576 (32%), Positives = 262/576 (45%), Gaps = 96/576 (16%)
Query: 487 PKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCF 546
P+ +CG RP E R+VGG A G PWQVSL G H CG +++ W+LSAAHCF
Sbjct: 33 PEDLDCG-RP--EPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCF 89
Query: 547 NHTKVEQVRAH----LGTASLLG-LGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASP 601
+ A LG S G L G+ + + +V+ Y+ L DLA+L LASP
Sbjct: 90 MTNGTLEPAAEWSVLLGVHSQDGPLDGAHTR-AVAAIVVPANYSQVELGADLALLRLASP 148
Query: 602 LAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATK-PELLQKASVGIIDQKTCSV 660
+ + PVCLP A +F G C +GWG+ QE + P +LQ+ + ++ + TC
Sbjct: 149 ASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQC 208
Query: 661 LYN----FSLT----DRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGC 712
LY+ F+LT M+CAG+ EG+ D+CQGDSGGPL CEE G ++ AGI S+G GC
Sbjct: 209 LYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEG-GRWFQAGITSFGFGC 267
Query: 713 AQVKKPGVYTRITRLKGWILE-IMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSR 771
+ +PGV+T + + WI E +M S+P P P T P+ T + P
Sbjct: 268 GRRNRPGVFTAVATYEAWIREQVMGSEPGPAFP---------TQPQKTQ------SDPQE 312
Query: 772 PTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGS 831
P + N T++ LP+CG AP
Sbjct: 313 P----------REENCTIA-----------------------LPECGKAPRP-------- 331
Query: 832 AAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCF-DVYGDPKQWAAFLGTPFLSG 890
G WPW+ + + C LV+E W+L+ A CF D L
Sbjct: 332 ----GAWPWEAQVMV-PGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLLP 386
Query: 891 AEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCV 950
+ + ERVAR+ +H + + D+ALL+L PV S RP+CLP P G+RC
Sbjct: 387 SRPRAERVARLVQHENAS-WDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCR 445
Query: 951 ITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISS--------RMLCAGFPQ-GG 1001
+ WG L+ LL C Y Q ++ LC + +
Sbjct: 446 LARWGRGEPALGPGALLE---AELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEE 502
Query: 1002 VDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRP 1037
V SC D+ L C+E G W L G+ + GC RP
Sbjct: 503 VGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGCLRP 537
Score = 231 bits (590), Expect = 2e-60
Identities = 170/534 (31%), Positives = 234/534 (43%), Gaps = 64/534 (11%)
Query: 200 AGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF---NEFQDPTKWVA 256
+ RIVGG A PG +PWQ SL H CG ++I W++SAAHCF + +W
Sbjct: 44 SARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSV 103
Query: 257 YVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAA 316
+G G V IV Y+ D+A+L L SP G + PVCLP A
Sbjct: 104 LLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRA 163
Query: 317 THIFPPSKKCLISGWGYLKE-DFLVKPEVLQKATVELLDQALCASLYGH--------SLT 367
+H F C +GWG ++E D L P VLQ+ + LL +A C LY +
Sbjct: 164 SHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQIL 223
Query: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427
M+CAGY +G+ D+CQGDSGGPLVCEE GR+F AGI S+G GC RPGV+ V
Sbjct: 224 PGMLCAGYPEGRRDTCQGDSGGPLVCEE-GGRWFQAGITSFGFGCGRRNRPGVFTAVATY 282
Query: 428 RDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVP 487
WI E + P A+PT P+ S P + + T+
Sbjct: 283 EAWIREQVMGSE-------------PGPAFPTQPQK-TQSDPQEPREENCTI-------- 320
Query: 488 KLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFN 547
L ECG P G PW+ + C +V + W+L+ A CF
Sbjct: 321 ALPECGKAP--------------RPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFL 366
Query: 548 HTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607
A + L P + R+V H + DLA+L+L +P+ +
Sbjct: 367 DPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHENASWDNAS-DLALLQLRTPVNLSAA 425
Query: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLT 667
+PVCLP F G +C ++ WG + A P L +A ++ C LY
Sbjct: 426 SRPVCLPHPEHYFLPGSRCRLARWGRGEP--ALGPGALLEAE--LLGGWWCHCLYGRQGA 481
Query: 668 --------DRMICAGFLE-GKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGC 712
+C + E +V SC DS L C+E G ++LAGI + GC
Sbjct: 482 AVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGC 534
Score = 189 bits (480), Expect = 1e-47
Identities = 113/257 (43%), Positives = 140/257 (54%), Gaps = 18/257 (7%)
Query: 816 DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875
DCG P RIVGGS A G WPWQVSL H CG L+A W+LSAAHCF G
Sbjct: 37 DCG-RPEPSARIVGGSNAQPGTWPWQVSLH-HGGGHICGGSLIAPSWVLSAAHCFMTNGT 94
Query: 876 PK---QWAAFLGTPFLSGA-EGQLER-VARIYKHPFYNLYTLDYDVALLELAGPVRRSRL 930
+ +W+ LG G +G R VA I Y+ L D+ALL LA P
Sbjct: 95 LEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPA 154
Query: 931 VRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQ--LQKAAVRLLSEQTCRRFYP--- 985
V P+CLP + R GT C TGWG V+E + LQ+ +RLL E TC+ Y
Sbjct: 155 VWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPG 214
Query: 986 -----VQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFP 1040
+QI MLCAG+P+G D+C GD+GGPL C E GRW G+TS+G+GCGR + P
Sbjct: 215 PFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEE-GGRWFQAGITSFGFGCGRRNRP 273
Query: 1041 GVYTRVAAVRGWIGQHI 1057
GV+T VA WI + +
Sbjct: 274 GVFTAVATYEAWIREQV 290
Score = 138 bits (347), Expect = 3e-32
Identities = 142/553 (25%), Positives = 216/553 (39%), Gaps = 87/553 (15%)
Query: 173 ECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAI 232
+ D QE + A ECG P PG +PW+A + C A+
Sbjct: 307 QSDPQEPREENCTIALPECGKAPR--------------PGAWPWEAQVMVPGSRPCHGAL 352
Query: 233 INARWLVSAAHCF---NEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTA 289
++ W+++ A CF N P + + S A +V ++V+H + D A
Sbjct: 353 VSESWVLAPASCFLDPNSSDSPPRDLDAWRVLLPSRPRAE----RVARLVQHENASWDNA 408
Query: 290 DFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKAT 349
D+A+L+L +P+ +PVCLP H F P +C ++ WG + + + P L +A
Sbjct: 409 S-DLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWG--RGEPALGPGALLEA- 464
Query: 350 VELLDQALCASLYGHSLT--------DRMVCAGYLDGK-VDSCQGDSGGPLVCEEPSGRF 400
ELL C LYG +C Y + + V SC DS L+C+E G +
Sbjct: 465 -ELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQE-EGTW 522
Query: 401 FLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTS 460
FLAGI + GC RP + + WI T A + AW
Sbjct: 523 FLAGIRDFPSGCL---RPRAFFPLQTHGPWISHVTRGAYL-----------EDQLAWDWG 568
Query: 461 PESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVS 520
P+ T T + CG R P V+ PW
Sbjct: 569 PDGEETETQTCPPHT------------EHGACGLR-LEAAPVGVLW---------PWLAE 606
Query: 521 LKEGSRHFCGATVVGDRWLLSAAHCF---NHTKVEQVRAHLGTASLLGLGGSPVKIGLRR 577
+ C ++ W+L+A HC T V + +LG A G P + R
Sbjct: 607 VHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRA---GASSLPQGHQVSR 663
Query: 578 VVLHPLYNPGI-LDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQE 636
+V+ + L LA+LEL+S + + P+CL A P G C + GW Q+
Sbjct: 664 LVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGWKEPQD 721
Query: 637 GNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEA 696
+ A+V I+ Q+ C LY L +C + EG+ + C+ S PL C+
Sbjct: 722 ------RVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMT 775
Query: 697 PGVFYLAGIVSWG 709
G + L G+ G
Sbjct: 776 EGSWILVGMAVQG 788
Score = 72.8 bits (177), Expect = 2e-12
Identities = 72/267 (26%), Positives = 109/267 (40%), Gaps = 36/267 (13%)
Query: 803 PDAPEATT-----HTQLPDCGLA-PAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAV 856
PD E T HT+ CGL AA ++ WPW + + + C +
Sbjct: 569 PDGEETETQTCPPHTEHGACGLRLEAAPVGVL---------WPWLAEVHVAG-DRVCTGI 618
Query: 857 LVAERWLLSAAHCFDVYGDPK--QWAAFLGTPFLSGAEG--QLERVARIYKHPFYNLYTL 912
L+A W+L+A HC G +LG S Q+ R+ + P + L
Sbjct: 619 LLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQH--LGL 676
Query: 913 DYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAV 972
+ALLEL+ V S PICL PA PP G C + GW ++ +A AAV
Sbjct: 677 RPPLALLELSSRVEPSPSALPICL-HPAGIPP-GASCWVLGWKEPQDRVPVA-----AAV 729
Query: 973 RLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGY 1032
+L+++ C Y + LC + +G + C + PL C+ G W+L G+ G
Sbjct: 730 SILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG- 788
Query: 1033 GCGRPHFPGVYTRVAAVRGWIGQHIQE 1059
++ + WI Q + E
Sbjct: 789 ------SRELFAAIGPEEAWISQTVGE 809
Score = 70.5 bits (171), Expect = 8e-12
Identities = 71/295 (24%), Positives = 123/295 (41%), Gaps = 47/295 (15%)
Query: 172 PECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGGMEASPGE--FPWQASLRENKEHFCG 229
P+ ++ E + H CGL+ +EA+P +PW A + + C
Sbjct: 569 PDGEETETQTCPPHTEHGACGLR------------LEAAPVGVLWPWLAEVHVAGDRVCT 616
Query: 230 AAIINARWLVSAAHCFNEFQDPTKWVAYVGATYLSGSEASTVR-----AQVVQIVKHPLY 284
++ W+++A HC + + V Y+ YL + AS++ +++V ++ P +
Sbjct: 617 GILLAPGWVLAATHCV--LRPGSTTVPYI-EVYLGRAGASSLPQGHQVSRLVISIRLPQH 673
Query: 285 NADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEV 344
+A+LEL+S + P+CL A PP C + GW KE + V
Sbjct: 674 LGLRP--PLALLELSSRVEPSPSALPICLHPAG--IPPGASCWVLGW---KEP---QDRV 723
Query: 345 LQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAG 404
A V +L Q +C LY L +C Y +G+ + C+ S PL+C+ G + L G
Sbjct: 724 PVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVG 783
Query: 405 IVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPT 459
+ G ++A + WI + +A+ P + S WPT
Sbjct: 784 MAVQG-------SRELFAAIGPEEAWISQTVGEANF--------LPPSGSPHWPT 823
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 234 bits (598), Expect = 2e-61
Identities = 132/311 (42%), Positives = 174/311 (55%), Gaps = 24/311 (7%)
Query: 139 RHKGPL---AERDFKSGR----------CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSD 185
R GPL RD ++GR C +F CGN C K N +CD DC DGSD
Sbjct: 405 RQHGPLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSD 464
Query: 186 EAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF 245
E C C + RI+GG + G +PWQ SL +CGA++I+ WL+SAAHCF
Sbjct: 465 EEGCTCSRSSS--ALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCF 522
Query: 246 --NEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLP 303
N DPT W A++G Y+ G+ + + V +IV H YN+ T D+D+A+L+L+ P
Sbjct: 523 HGNRLSDPTPWTAHLG-MYVQGN--AKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWP 579
Query: 304 --FGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASL 361
+ IQP+C+P +KC ++GWG E VLQ+A VEL+DQ LC S
Sbjct: 580 ETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVST 639
Query: 362 YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPS-GRFFLAGIVSWGIGCAEARRPGV 420
YG +T RM+CAG + GK D+C+GDSGGPL C S G++ L GIVSWG G PGV
Sbjct: 640 YG-IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGV 698
Query: 421 YARVTRLRDWI 431
Y RV+ WI
Sbjct: 699 YTRVSNFVPWI 709
Score = 213 bits (542), Expect = 8e-55
Identities = 114/249 (45%), Positives = 153/249 (61%), Gaps = 13/249 (5%)
Query: 817 CGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCF--DVYG 874
C + +AL RI+GG+ G WPWQVSL + CGA +++ WLLSAAHCF +
Sbjct: 470 CSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAY-CGASVISREWLLSAAHCFHGNRLS 528
Query: 875 DPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLEL--AGPVRRSRLVR 932
DP W A LG ++ G + V RI H +YN T DYD+ALL+L A P +L++
Sbjct: 529 DPTPWTAHLGM-YVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQ 587
Query: 933 PICLPEPAPRPPDGTRCVITGWGSVREG---GSMARQLQKAAVRLLSEQTCRRFYPVQIS 989
PIC+P R G +C +TGWG E GS+ LQ+A V L+ + C Y + I+
Sbjct: 588 PICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLV--LQQAEVELIDQTLCVSTYGI-IT 644
Query: 990 SRMLCAGFPQGGVDSCSGDAGGPLACREPS-GRWVLTGVTSWGYGCGRPHFPGVYTRVAA 1048
SRMLCAG G D+C GD+GGPL+CR S G+W+LTG+ SWG+G GRP+FPGVYTRV+
Sbjct: 645 SRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSN 704
Query: 1049 VRGWIGQHI 1057
WI +++
Sbjct: 705 FVPWIHKYV 713
Score = 186 bits (472), Expect = 1e-46
Identities = 99/241 (41%), Positives = 140/241 (58%), Gaps = 10/241 (4%)
Query: 503 RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQV---RAHLG 559
R++GG G PWQVSL +CGA+V+ WLLSAAHCF+ ++ AHLG
Sbjct: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538
Query: 560 TASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLEL--ASPLAFNKYIQPVCLPLAI 617
+ G + +RR+V+H YN D+D+A+L+L A P + IQP+C+P
Sbjct: 539 ---MYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTG 595
Query: 618 QKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLE 677
Q+ G KC ++GWG E + +LQ+A V +IDQ C Y +T RM+CAG +
Sbjct: 596 QRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGI-ITSRMLCAGIMS 654
Query: 678 GKVDSCQGDSGGPLAC-EEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMS 736
GK D+C+GDSGGPL+C ++ G + L GIVSWG G + PGVYTR++ WI + +
Sbjct: 655 GKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVP 714
Query: 737 S 737
S
Sbjct: 715 S 715
Score = 36.2 bits (82), Expect = 0.17
Identities = 16/36 (44%), Positives = 18/36 (50%), Gaps = 1/36 (2%)
Query: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC 189
CP SF C + CV + CD DC D SDE C
Sbjct: 358 CPVGSFRCSSGLCVPQAQ-RCDGVNDCFDESDELFC 392
>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
Length = 423
Score = 218 bits (555), Expect = 2e-56
Identities = 112/252 (44%), Positives = 157/252 (62%), Gaps = 10/252 (3%)
Query: 188 HCECGLQPAWRMAG--RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF 245
HC CG + + + RIVGG E GE+PWQASL+ + H CGA +INA WLVSAAHCF
Sbjct: 176 HC-CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF 234
Query: 246 NEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFG 305
+++P +W A G T + S ++ + +I+ H Y + D+D+++ EL+SP+P+
Sbjct: 235 TTYKNPARWTASFGVTI----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYT 290
Query: 306 RHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYG 363
+ VCLP A++ F P ++G+G LK D + L++A V L+D C Y
Sbjct: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNH-LRQAQVTLIDATTCNEPQAYN 349
Query: 364 HSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYAR 423
++T RM+CAG L+GK D+CQGDSGGPLV + ++LAGIVSWG CA+ +PGVY R
Sbjct: 350 DAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTR 409
Query: 424 VTRLRDWILEAT 435
VT LRDWI T
Sbjct: 410 VTALRDWITSKT 421
Score = 196 bits (497), Expect = 1e-49
Identities = 107/245 (43%), Positives = 148/245 (60%), Gaps = 10/245 (4%)
Query: 492 CGARPA--MEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549
CG R + + + R+VGG GE PWQ SL+ H CGAT++ WL+SAAHCF
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 550 KVEQVRAHLGTASL-LGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYI 608
K TAS + + S +K GLRR+++H Y D+D+++ EL+SP+ + +
Sbjct: 238 K----NPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAV 293
Query: 609 QPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSL 666
VCLP A +F G ++G+G + ++ L Q A V +ID TC+ YN ++
Sbjct: 294 HRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQ-AQVTLIDATTCNEPQAYNDAI 352
Query: 667 TDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITR 726
T RM+CAG LEGK D+CQGDSGGPL +A ++YLAGIVSWG CA+ KPGVYTR+T
Sbjct: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTA 412
Query: 727 LKGWI 731
L+ WI
Sbjct: 413 LRDWI 417
Score = 185 bits (469), Expect = 2e-46
Identities = 99/234 (42%), Positives = 132/234 (56%), Gaps = 13/234 (5%)
Query: 826 RIVGGSAAGRGEWPWQVSL-WLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLG 884
RIVGG+ GEWPWQ SL W HRCGA L+ WL+SAAHCF Y +P +W A G
Sbjct: 191 RIVGGTEVEEGEWPWQASLQW--DGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFG 248
Query: 885 TPFL-SGAEGQLERVA--RIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAP 941
S + L R+ YKHP + DYD++L EL+ PV + V +CLP+ +
Sbjct: 249 VTIKPSKMKRGLRRIIVHEKYKHPSH-----DYDISLAELSSPVPYTNAVHRVCLPDASY 303
Query: 942 RPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCR--RFYPVQISSRMLCAGFPQ 999
G +TG+G+++ G L++A V L+ TC + Y I+ RMLCAG +
Sbjct: 304 EFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE 363
Query: 1000 GGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
G D+C GD+GGPL + W L G+ SWG C +P+ PGVYTRV A+R WI
Sbjct: 364 GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
Length = 423
Score = 218 bits (555), Expect = 2e-56
Identities = 112/252 (44%), Positives = 157/252 (62%), Gaps = 10/252 (3%)
Query: 188 HCECGLQPAWRMAG--RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF 245
HC CG + + + RIVGG E GE+PWQASL+ + H CGA +INA WLVSAAHCF
Sbjct: 176 HC-CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF 234
Query: 246 NEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFG 305
+++P +W A G T + S ++ + +I+ H Y + D+D+++ EL+SP+P+
Sbjct: 235 TTYKNPARWTASFGVTI----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYT 290
Query: 306 RHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYG 363
+ VCLP A++ F P ++G+G LK D + L++A V L+D C Y
Sbjct: 291 NAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNH-LRQAQVTLIDATTCNEPQAYN 349
Query: 364 HSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYAR 423
++T RM+CAG L+GK D+CQGDSGGPLV + ++LAGIVSWG CA+ +PGVY R
Sbjct: 350 DAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTR 409
Query: 424 VTRLRDWILEAT 435
VT LRDWI T
Sbjct: 410 VTALRDWITSKT 421
Score = 196 bits (497), Expect = 1e-49
Identities = 107/245 (43%), Positives = 148/245 (60%), Gaps = 10/245 (4%)
Query: 492 CGARPA--MEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549
CG R + + + R+VGG GE PWQ SL+ H CGAT++ WL+SAAHCF
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 550 KVEQVRAHLGTASL-LGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYI 608
K TAS + + S +K GLRR+++H Y D+D+++ EL+SP+ + +
Sbjct: 238 K----NPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAV 293
Query: 609 QPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSL 666
VCLP A +F G ++G+G + ++ L Q A V +ID TC+ YN ++
Sbjct: 294 HRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQ-AQVTLIDATTCNEPQAYNDAI 352
Query: 667 TDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITR 726
T RM+CAG LEGK D+CQGDSGGPL +A ++YLAGIVSWG CA+ KPGVYTR+T
Sbjct: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTA 412
Query: 727 LKGWI 731
L+ WI
Sbjct: 413 LRDWI 417
Score = 185 bits (469), Expect = 2e-46
Identities = 99/234 (42%), Positives = 132/234 (56%), Gaps = 13/234 (5%)
Query: 826 RIVGGSAAGRGEWPWQVSL-WLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLG 884
RIVGG+ GEWPWQ SL W HRCGA L+ WL+SAAHCF Y +P +W A G
Sbjct: 191 RIVGGTEVEEGEWPWQASLQW--DGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFG 248
Query: 885 TPFL-SGAEGQLERVA--RIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAP 941
S + L R+ YKHP + DYD++L EL+ PV + V +CLP+ +
Sbjct: 249 VTIKPSKMKRGLRRIIVHEKYKHPSH-----DYDISLAELSSPVPYTNAVHRVCLPDASY 303
Query: 942 RPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCR--RFYPVQISSRMLCAGFPQ 999
G +TG+G+++ G L++A V L+ TC + Y I+ RMLCAG +
Sbjct: 304 EFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE 363
Query: 1000 GGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
G D+C GD+GGPL + W L G+ SWG C +P+ PGVYTRV A+R WI
Sbjct: 364 GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 213 bits (542), Expect = 8e-55
Identities = 109/246 (44%), Positives = 144/246 (58%), Gaps = 9/246 (3%)
Query: 190 ECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQ 249
ECG +P +A RIVGG +PG +PWQAS+ H CG +++ RW+V+AAHC + F+
Sbjct: 208 ECGARP---LASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFR 264
Query: 250 DP--TKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRH 307
+ W + G S A V +I+ HPLY+A D+DVA+L L + L F
Sbjct: 265 LARLSSWRVHAGLVSHSAVRPHQ-GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDT 323
Query: 308 IQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHS 365
+ VCLPA FP +C +SGWG+ ++LQ V L LC S +Y +
Sbjct: 324 VGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGA 383
Query: 366 LTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVT 425
LT RM+CAGYLDG+ D+CQGDSGGPLVC + + L G+VSWG GCAE PGVYA+V
Sbjct: 384 LTPRMLCAGYLDGRADACQGDSGGPLVCPD-GDTWRLVGVVSWGRGCAEPNHPGVYAKVA 442
Query: 426 RLRDWI 431
DWI
Sbjct: 443 EFLDWI 448
Score = 199 bits (506), Expect = 1e-50
Identities = 100/249 (40%), Positives = 145/249 (58%), Gaps = 10/249 (4%)
Query: 488 KLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC-- 545
+ ECGARP +R+VGG A G PWQ S+ G RH CG +V+ RW+++AAHC
Sbjct: 205 RCSECGARPLA---SRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMH 261
Query: 546 -FNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAF 604
F ++ R H G S + + + R++ HPLY+ D+D+A+L L + L F
Sbjct: 262 SFRLARLSSWRVHAGLVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNF 320
Query: 605 NKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTC--SVLY 662
+ + VCLP Q FP G +C +SGWG+T + ++LQ V + + C S +Y
Sbjct: 321 SDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVY 380
Query: 663 NFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYT 722
+ +LT RM+CAG+L+G+ D+CQGDSGGPL C + + L G+VSWG GCA+ PGVY
Sbjct: 381 SGALTPRMLCAGYLDGRADACQGDSGGPLVCPDG-DTWRLVGVVSWGRGCAEPNHPGVYA 439
Query: 723 RITRLKGWI 731
++ WI
Sbjct: 440 KVAEFLDWI 448
Score = 175 bits (443), Expect = 2e-43
Identities = 102/251 (40%), Positives = 129/251 (51%), Gaps = 11/251 (4%)
Query: 816 DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875
+CG P A +RIVGG + G WPWQ S+ L R H CG ++A RW+++AAHC +
Sbjct: 208 ECGARPLA-SRIVGGQSVAPGRWPWQASVALGFR-HTCGGSVLAPRWVVTAAHCMHSFRL 265
Query: 876 PK--QWAAFLGTPFLSGAEG-QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVR 932
+ W G S Q V RI HP Y+ DYDVALL L + S V
Sbjct: 266 ARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG 325
Query: 933 PICLPEPAPRPPDGTRCVITGWGSVREGGSMAR-QLQKAAVRLLSEQTCRR--FYPVQIS 989
+CLP P G+RC ++GWG + + LQ V L S Q C Y ++
Sbjct: 326 AVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALT 385
Query: 990 SRMLCAGFPQGGVDSCSGDAGGPLACREPSG-RWVLTGVTSWGYGCGRPHFPGVYTRVAA 1048
RMLCAG+ G D+C GD+GGPL C P G W L GV SWG GC P+ PGVY +VA
Sbjct: 386 PRMLCAGYLDGRADACQGDSGGPLVC--PDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAE 443
Query: 1049 VRGWIGQHIQE 1059
WI Q+
Sbjct: 444 FLDWIHDTAQD 454
>gi|87196600 polyserase 3 [Homo sapiens]
Length = 553
Score = 210 bits (534), Expect = 7e-54
Identities = 155/583 (26%), Positives = 247/583 (42%), Gaps = 87/583 (14%)
Query: 192 GLQPAWRMAGRIVGGM------EASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF 245
GLQ A R G+ G PGE+PWQAS+R H C +++ W+++AAHCF
Sbjct: 20 GLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCF 79
Query: 246 NEFQ--DPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLP 303
+ + W +G+ G V + YN + D+A+L+L P
Sbjct: 80 EKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTT 139
Query: 304 FGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYG 363
P+CLP H FP C +GW +D P L+ + L+ + C +Y
Sbjct: 140 H----TPLCLPQPAHRFPFGASCWATGWD---QDTSDAPGTLRNLRLRLISRPTCNCIYN 192
Query: 364 --------HSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEA 415
+ M+C G G CQGDSGGP++C EP G + AGI+S+ CA+
Sbjct: 193 QLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQE 252
Query: 416 RRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQA 475
P + W L+A + + LA SPE+P +S +
Sbjct: 253 DAPVLLTNTAAHSSW-LQARVQGAAFLAQ---------------SPETPEMSDEDSCVA- 295
Query: 476 LSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVG 535
CG+ R G A PW+ L + CG +V
Sbjct: 296 ----------------CGS-------LRTAGPQAGAPSPWPWEARLMHQGQLACGGALVS 332
Query: 536 DRWLLSAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAV 595
+ +L+AAHCF + + + +GLG P + GL++++LH Y +D+A+
Sbjct: 333 EEAVLTAAHCFIGRQAPEEWS-------VGLGTRPEEWGLKQLILHGAYTHPEGGYDMAL 385
Query: 596 LELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQ 655
L LA P+ ++P+CLP P G + + G G ++ LQ V ++
Sbjct: 386 LLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISS----LQTVPVTLLGP 441
Query: 656 KTCSVLY------NFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWG 709
+ CS L+ + M+C + G++ SC+G SG PL E G ++LAG+ S+G
Sbjct: 442 RACSRLHAAPGGDGSPILPGMVCTSAV-GELPSCEGLSGAPLV-HEVRGTWFLAGLHSFG 499
Query: 710 IGCAQVKKPGVYTRITRLKGWILEI-----MSSQPLPMSPPST 747
C +P V+T + + W+ + + +P P + P +
Sbjct: 500 DACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGS 542
Score = 140 bits (353), Expect = 6e-33
Identities = 88/237 (37%), Positives = 118/237 (49%), Gaps = 23/237 (9%)
Query: 836 GEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYG--DPKQWAAFLGTPFLSGAEG 893
GEWPWQ S+ R+ H C LVA+ W+L+AAHCF+ + W+ LG+ G
Sbjct: 46 GEWPWQASV-RRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSP 104
Query: 894 QLERV--ARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVI 951
E V A + YN Y+ D+ALL+LA P + P+CLP+PA R P G C
Sbjct: 105 GAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTTHT----PLCLPQPAHRFPFGASCWA 160
Query: 952 TGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSR---------MLCAGFPQGGV 1002
TGW ++ L+ +RL+S TC Y Q+ R MLC G PQ GV
Sbjct: 161 TGWD--QDTSDAPGTLRNLRLRLISRPTCNCIYN-QLHQRHLSNPARPGMLCGG-PQPGV 216
Query: 1003 DS-CSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQ 1058
C GD+GGP+ C EP G WV G+ S+ C + P + T AA W+ +Q
Sbjct: 217 QGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQ 273
Score = 137 bits (344), Expect = 7e-32
Identities = 90/296 (30%), Positives = 126/296 (42%), Gaps = 25/296 (8%)
Query: 492 CGAR-PAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTK 550
CG R P KP GE PWQ S++ H C ++V D W+L+AAHCF
Sbjct: 28 CGQRGPGPPKPQEG----NTVPGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAA 83
Query: 551 VEQVRAH---LGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607
++ + LG+ GL ++G+ + L YN DLA+L+LA P
Sbjct: 84 ATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTTHT-- 141
Query: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLT 667
P+CLP +FP G C +GW + + P L+ + +I + TC+ +YN L
Sbjct: 142 --PLCLPQPAHRFPFGASCWATGW---DQDTSDAPGTLRNLRLRLISRPTCNCIYN-QLH 195
Query: 668 DR---------MICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKP 718
R M+C G G CQGDSGGP+ C E G + AGI+S+ CAQ P
Sbjct: 196 QRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAP 255
Query: 719 GVYTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTP 774
+ T W+ + P T M S L G P+P
Sbjct: 256 VLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSP 311
Score = 118 bits (296), Expect = 3e-26
Identities = 85/259 (32%), Positives = 116/259 (44%), Gaps = 27/259 (10%)
Query: 803 PDAPEATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERW 862
P+ PE + CG R G A WPW+ L + + + CG LV+E
Sbjct: 282 PETPEMSDEDSCVACGSL-----RTAGPQAGAPSPWPWEARL-MHQGQLACGGALVSEEA 335
Query: 863 LLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELA 922
+L+AAHCF P++W+ LGT + + ++ H Y YD+ALL LA
Sbjct: 336 VLTAAHCFIGRQAPEEWSVGLGT------RPEEWGLKQLILHGAYTHPEGGYDMALLLLA 389
Query: 923 GPVRRSRLVRPICLPEPAPRPPDGTRCVITGW--GSVREGGSMARQLQKAAVRLLSEQTC 980
PV +RP+CLP P PDG R GW G R G ++ LQ V LL + C
Sbjct: 390 QPVTLGASLRPLCLPYPDHHLPDGER----GWVLGRARPGAGIS-SLQTVPVTLLGPRAC 444
Query: 981 RRFYPV------QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGC 1034
R + I M+C G + SC G +G PL E G W L G+ S+G C
Sbjct: 445 SRLHAAPGGDGSPILPGMVCTS-AVGELPSCEGLSGAPLV-HEVRGTWFLAGLHSFGDAC 502
Query: 1035 GRPHFPGVYTRVAAVRGWI 1053
P P V+T + A W+
Sbjct: 503 QGPARPAVFTALPAYEDWV 521
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 204 bits (519), Expect = 4e-52
Identities = 100/244 (40%), Positives = 145/244 (59%), Gaps = 11/244 (4%)
Query: 198 RMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAY 257
RM R+VGG + GE+PWQ S++ N HFCG ++I +W+++AAHCF + + +
Sbjct: 30 RMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVL 89
Query: 258 VGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAAT 317
+GA L + A+V Q+ +PLY + DVA++EL +P+PF +I PVCLP +
Sbjct: 90 LGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPS 149
Query: 318 HIFPPSKKCLISGWGY-LKEDFLVKPEVLQKATVELLDQALCASLYG---------HSLT 367
IF C ++GWG +ED L +P +LQK V ++D C LY ++
Sbjct: 150 VIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIK 209
Query: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427
+ M+CAG+ +GK D+C+GDSGGPLVC + AG++SWG GCA RPGVY RVT
Sbjct: 210 NDMLCAGFEEGKKDACKGDSGGPLVCLVGQS-WLQAGVISWGEGCARQNRPGVYIRVTAH 268
Query: 428 RDWI 431
+WI
Sbjct: 269 HNWI 272
Score = 192 bits (488), Expect = 1e-48
Identities = 106/277 (38%), Positives = 157/277 (56%), Gaps = 15/277 (5%)
Query: 473 MQALSTVPLDWVTVPKLQECGARPAMEKP---TRVVGGFGAASGEVPWQVSLKEGSRHFC 529
M+ + VPL + Q A A +P R+VGG GE PWQVS++ HFC
Sbjct: 1 MRRPAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFC 60
Query: 530 GATVVGDRWLLSAAHCFNHT-KVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGI 588
G +++ ++W+L+AAHCF +T + + LG L+ G + +R+V +PLY
Sbjct: 61 GGSLIAEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTA 120
Query: 589 LDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGN-TQEGNATKPELLQK 647
D+A++EL +P+ F YI PVCLP F G C ++GWG+ ++E +P +LQK
Sbjct: 121 SSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQK 180
Query: 648 ASVGIIDQKTCSVLYN---------FSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPG 698
+V IID C++LY+ ++ + M+CAGF EGK D+C+GDSGGPL C
Sbjct: 181 LAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQS 240
Query: 699 VFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIM 735
+ AG++SWG GCA+ +PGVY R+T WI I+
Sbjct: 241 -WLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRII 276
Score = 182 bits (462), Expect = 1e-45
Identities = 103/250 (41%), Positives = 130/250 (52%), Gaps = 16/250 (6%)
Query: 817 CGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDP 876
CG P L R+VGG GEWPWQVS+ R H CG L+AE+W+L+AAHCF +
Sbjct: 26 CG-RPRMLNRMVGGQDTQEGEWPWQVSIQ-RNGSHFCGGSLIAEQWVLTAAHCFRNTSET 83
Query: 877 KQWAAFLGTPFL--SGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPI 934
+ LG L G RV ++ +P Y DVAL+EL PV + + P+
Sbjct: 84 SLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPV 143
Query: 935 CLPEPAPRPPDGTRCVITGWGSVREGGSM--ARQLQKAAVRLLSEQTCRRFY-------- 984
CLP+P+ G C +TGWGS E + R LQK AV ++ C Y
Sbjct: 144 CLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGY 203
Query: 985 -PVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVY 1043
P I + MLCAGF +G D+C GD+GGPL C W+ GV SWG GC R + PGVY
Sbjct: 204 QPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQS-WLQAGVISWGEGCARQNRPGVY 262
Query: 1044 TRVAAVRGWI 1053
RV A WI
Sbjct: 263 IRVTAHHNWI 272
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 197 bits (500), Expect = 6e-50
Identities = 103/248 (41%), Positives = 144/248 (58%), Gaps = 8/248 (3%)
Query: 816 DCGLAPAALT--RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVY 873
DCG PAA RI+GG + G WPWQ SL H CG VL+A++W+L+ AHCF+
Sbjct: 789 DCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGR 848
Query: 874 GDPKQWAAFLGTPFLSGAEG--QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLV 931
+ W LG L Q V I HP Y+ +DYD++++EL+ + + V
Sbjct: 849 ENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYV 908
Query: 932 RPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQ-ISS 990
RP+CLP P T C ITGWG + G M +LQ+ VR++S + C+ ++ ++ I++
Sbjct: 909 RPVCLPNPEQWLEPDTYCYITGWGHM--GNKMPFKLQEGEVRIISLEHCQSYFDMKTITT 966
Query: 991 RMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGC-GRPHFPGVYTRVAAV 1049
RM+CAG+ G VDSC GD+GGPL C +P GRW L G+TSWG C + PGVY+ V+
Sbjct: 967 RMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYF 1026
Query: 1050 RGWIGQHI 1057
WI + I
Sbjct: 1027 VEWIKRQI 1034
Score = 189 bits (480), Expect = 1e-47
Identities = 94/245 (38%), Positives = 138/245 (56%), Gaps = 6/245 (2%)
Query: 190 ECGLQPAWRMAGRIVGGMEASPGEFPWQASLR-ENKEHFCGAAIINARWLVSAAHCFNEF 248
+CG +PA RM RI+GG + PG +PWQ SL+ E H CG +I +W+++ AHCF
Sbjct: 789 DCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGR 848
Query: 249 QDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHI 308
++ W +G L V I+ HP Y+ D+D++++EL+ + ++
Sbjct: 849 ENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYV 908
Query: 309 QPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYG-HSLT 367
+PVCLP P C I+GWG++ P LQ+ V ++ C S + ++T
Sbjct: 909 RPVCLPNPEQWLEPDTYCYITGWGHMGNKM---PFKLQEGEVRIISLEHCQSYFDMKTIT 965
Query: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGC-AEARRPGVYARVTR 426
RM+CAGY G VDSC GDSGGPLVCE+P GR+ L G+ SWG C ++ PGVY+ V+
Sbjct: 966 TRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSY 1025
Query: 427 LRDWI 431
+WI
Sbjct: 1026 FVEWI 1030
Score = 171 bits (433), Expect = 3e-42
Identities = 94/246 (38%), Positives = 141/246 (57%), Gaps = 7/246 (2%)
Query: 490 QECGARPAMEKPTRVVGGFGAASGEVPWQVSLK-EGSRHFCGATVVGDRWLLSAAHCFNH 548
Q+CG RPA R++GG + G PWQ SL+ E S H CG ++ +W+L+ AHCF
Sbjct: 788 QDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEG 847
Query: 549 TKVEQV-RAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607
+ V + LG +L ++ ++LHP Y+ ++D+D++++EL+ ++ Y
Sbjct: 848 RENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGY 907
Query: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNF-SL 666
++PVCLP Q C I+GWG+ GN P LQ+ V II + C ++ ++
Sbjct: 908 VRPVCLPNPEQWLEPDTYCYITGWGHM--GNKM-PFKLQEGEVRIISLEHCQSYFDMKTI 964
Query: 667 TDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGC-AQVKKPGVYTRIT 725
T RMICAG+ G VDSC GDSGGPL CE+ G + L G+ SWG C ++V PGVY+ ++
Sbjct: 965 TTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVS 1024
Query: 726 RLKGWI 731
WI
Sbjct: 1025 YFVEWI 1030
Score = 42.4 bits (98), Expect = 0.002
Identities = 18/44 (40%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQPAW 197
C + F C + QCV + CD Q DC D SDE +C C + W
Sbjct: 580 CSPSHFKCRSGQCVL-ASRRCDGQADCDDDSDEENCGCKERDLW 622
Score = 37.7 bits (86), Expect = 0.058
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 156 GNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCEC 191
G +F C + C+ +C+ DC D SDEAHC C
Sbjct: 272 GENFLCASGICIPG-KLQCNGYNDCDDWSDEAHCNC 306
Score = 37.7 bits (86), Expect = 0.058
Identities = 15/29 (51%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Query: 161 CGNSQCVTKVNPECDDQEDCSDGSDEAHC 189
C N QC+ +CD EDC DGSDE +C
Sbjct: 387 CRNGQCIPSTF-QCDGDEDCKDGSDEENC 414
Score = 36.6 bits (83), Expect = 0.13
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCEC 191
C N F C +C+ + CD +DC D SDE +C+C
Sbjct: 306 CSENLFHCHTGKCLN-YSLVCDGYDDCGDLSDEQNCDC 342
Score = 35.8 bits (81), Expect = 0.22
Identities = 15/40 (37%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 155 PGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQ 194
P CG+ +C+ + CD DC D SDE +C C Q
Sbjct: 344 PTTEHRCGDGRCIA-MEWVCDGDHDCVDKSDEVNCSCHSQ 382
Score = 35.4 bits (80), Expect = 0.29
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC 189
C + C N CV++ + CD + DCSD SDE C
Sbjct: 655 CQDDELECANHACVSR-DLWCDGEADCSDSSDEWDC 689
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 195 bits (496), Expect = 2e-49
Identities = 100/241 (41%), Positives = 148/241 (61%), Gaps = 9/241 (3%)
Query: 503 RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTK---VEQVRAHLG 559
R+VGG A+ + PWQVSL G+ H CG T++ +W+L+AAHCF T+ +E + + G
Sbjct: 325 RIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAG 384
Query: 560 TASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQK 619
T++L L P + ++++ Y D+D+A++ L+ PL + +I P CLP+ Q
Sbjct: 385 TSNLHQL---PEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQT 441
Query: 620 FPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCS--VLYNFSLTDRMICAGFLE 677
F + C I+G+G T+E + L++ V +ID K C+ ++Y+ LT RM+CAG L
Sbjct: 442 FSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLR 501
Query: 678 GKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSS 737
G DSCQGDSGGPL CE+ +YLAG+ SWG GC Q KPGVYT++T + WI M S
Sbjct: 502 GGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMES 560
Query: 738 Q 738
+
Sbjct: 561 E 561
Score = 187 bits (476), Expect = 3e-47
Identities = 99/245 (40%), Positives = 141/245 (57%), Gaps = 11/245 (4%)
Query: 191 CGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQD 250
CGL+ M GRIVGG AS ++PWQ SL H CG +I+A+W+++AAHCF ++
Sbjct: 317 CGLRA---MTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTRE 373
Query: 251 PT--KWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHI 308
W Y G + L + A + +I+ + Y + D+D+A++ L+ PL HI
Sbjct: 374 KVLEGWKVYAGTSNLHQLPEA---ASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHI 430
Query: 309 QPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSL 366
P CLP F ++ C I+G+G +E L++ V L+D C +Y L
Sbjct: 431 HPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYL 490
Query: 367 TDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTR 426
T RM+CAG L G DSCQGDSGGPLVCE+ + R++LAG+ SWG GC + +PGVY +VT
Sbjct: 491 TPRMMCAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQRNKPGVYTKVTE 549
Query: 427 LRDWI 431
+ WI
Sbjct: 550 VLPWI 554
Score = 167 bits (424), Expect = 4e-41
Identities = 100/246 (40%), Positives = 132/246 (53%), Gaps = 9/246 (3%)
Query: 813 QLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV 872
Q CGL A RIVGG+ A +WPWQVSL H CG L+ +W+L+AAHCF V
Sbjct: 313 QCSHCGLR-AMTGRIVGGALASDSKWPWQVSLHFGTT-HICGGTLIDAQWVLTAAHCFFV 370
Query: 873 YGDP--KQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRL 930
+ + W + GT L + +A I + Y DYD+AL+ L+ P+ S
Sbjct: 371 TREKVLEGWKVYAGTSNLHQLP-EAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAH 429
Query: 931 VRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQ-LQKAAVRLLSEQTCRRF--YPVQ 987
+ P CLP C ITG+G RE L++ V L+ + C + Y
Sbjct: 430 IHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSY 489
Query: 988 ISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVA 1047
++ RM+CAG +GG DSC GD+GGPL C E + RW L GVTSWG GCG+ + PGVYT+V
Sbjct: 490 LTPRMMCAGDLRGGRDSCQGDSGGPLVC-EQNNRWYLAGVTSWGTGCGQRNKPGVYTKVT 548
Query: 1048 AVRGWI 1053
V WI
Sbjct: 549 EVLPWI 554
Score = 30.8 bits (68), Expect = 7.1
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 737 SQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRVTGQPANST--LSAVST 794
+ P SP T A+ + + AG A+P R +P AS PA ++ L+++S
Sbjct: 39 ASPAQASPAGTPPGRASPAQASPAGTPPGRASPGRASPAQASPAQASPARASPALASLSR 98
Query: 795 TARGQTPFPDAPEATT 810
++ G++ + TT
Sbjct: 99 SSSGRSSSARSASVTT 114
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 194 bits (493), Expect = 4e-49
Identities = 102/248 (41%), Positives = 149/248 (60%), Gaps = 6/248 (2%)
Query: 188 HCECGLQPAWR-MAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHC-F 245
H CG + A + + +IVGG A G +PW L CGA+++++ WLVSAAHC +
Sbjct: 769 HKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVY 828
Query: 246 NEFQDPTKWVAYVGATYLSG-SEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPF 304
+P+KW A +G S + TV + +IV +P YN D D+A++ L + +
Sbjct: 829 GRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNY 888
Query: 305 GRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC-ASLYG 363
+IQP+CLP +FPP + C I+GWG + +LQ+A V LL C +
Sbjct: 889 TDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQG-TTANILQEADVPLLSNERCQQQMPE 947
Query: 364 HSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYAR 423
+++T+ M+CAGY +G +DSCQGDSGGPL+C+E + R+FLAG+ S+G CA RPGVYAR
Sbjct: 948 YNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYAR 1006
Query: 424 VTRLRDWI 431
V+R +WI
Sbjct: 1007 VSRFTEWI 1014
Score = 189 bits (481), Expect = 9e-48
Identities = 109/247 (44%), Positives = 142/247 (57%), Gaps = 14/247 (5%)
Query: 817 CGLAPAA---LTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVY 873
CG AA +IVGGS A G WPW V L+ R CGA LV+ WL+SAAHC VY
Sbjct: 772 CGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRL-LCGASLVSSDWLVSAAHC--VY 828
Query: 874 G---DPKQWAAFLGTPF---LSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRR 927
G +P +W A LG L+ + + I +P YN D D+A++ L V
Sbjct: 829 GRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNY 888
Query: 928 SRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYP-V 986
+ ++PICLPE P G C I GWG+V G+ A LQ+A V LLS + C++ P
Sbjct: 889 TDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEY 948
Query: 987 QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRV 1046
I+ M+CAG+ +GG+DSC GD+GGPL C+E + RW L GVTS+GY C P+ PGVY RV
Sbjct: 949 NITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARV 1007
Query: 1047 AAVRGWI 1053
+ WI
Sbjct: 1008 SRFTEWI 1014
Score = 181 bits (459), Expect = 3e-45
Identities = 116/333 (34%), Positives = 172/333 (51%), Gaps = 26/333 (7%)
Query: 408 WGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVS 467
W CAE + V +L + +S P+ T P T+P+ ++
Sbjct: 699 WHTACAENWTTQISNDVCQLLGL---GSGNSSKPIFST----DGGPFVKLNTAPDGHLIL 751
Query: 468 TPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPT-RVVGGFGAASGEVPWQVSLKEGSR 526
TP++ S + L + CG + A + T ++VGG A G PW V L G R
Sbjct: 752 TPSQQCLQDSLIRLQC----NHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGR 807
Query: 527 HFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTASLLGLG-----GSPVKIG--LRRVV 579
CGA++V WL+SAAHC +E + ++LGL SP + + +V
Sbjct: 808 LLCGASLVSSDWLVSAAHCVYGRNLEPSK----WTAILGLHMKSNLTSPQTVPRLIDEIV 863
Query: 580 LHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNA 639
++P YN D D+A++ L + + YIQP+CLP Q FP GR C I+GWG T
Sbjct: 864 INPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQG 922
Query: 640 TKPELLQKASVGIIDQKTC-SVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPG 698
T +LQ+A V ++ + C + +++T+ MICAG+ EG +DSCQGDSGGPL C+E
Sbjct: 923 TTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NN 981
Query: 699 VFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWI 731
++LAG+ S+G CA +PGVY R++R WI
Sbjct: 982 RWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
Score = 40.0 bits (92), Expect = 0.012
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC 189
C + F C N +CV VN CD C DGSDEA C
Sbjct: 643 CKADHFQCKNGECVPLVNL-CDGHLHCEDGSDEADC 677
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 194 bits (492), Expect = 5e-49
Identities = 135/424 (31%), Positives = 208/424 (49%), Gaps = 41/424 (9%)
Query: 26 CRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHTAELRGIRWTSSLRRETSDYHRTLTP 85
C GVV ++ + L LAF + + + +L + + S L + +RTL+
Sbjct: 20 CFIVVAGVVILAVTIALLVYFLAF-DQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSG 78
Query: 86 TLEALLHFLLRPLQTLSLGLEEELLQRGIRA---RLREHGISLAAYGTIVSAELTGRHKG 142
+E+L+ + E L + IRA +LR+ G + A ++ + T + G
Sbjct: 79 RIESLITKTFK---------ESNLRNQFIRAHVAKLRQDGSGVRA-DVVMKFQFTRNNNG 128
Query: 143 PLAERDFKS--GRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC-----ECGLQP 195
+ +S + NS GN + +NP + + +D+A ECG P
Sbjct: 129 ASMKSRIESVLRQMLNNS---GNLE----INPSTE----ITSLTDQAAANWLINECGAGP 177
Query: 196 AWRMAG--RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTK 253
RI+GG EA G +PWQ SLR N H CG ++IN W+++AAHCF +P
Sbjct: 178 DLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRD 237
Query: 254 WVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCL 313
W+A G + + +R +V I+ H Y + T + D+A++ L + + F + I VCL
Sbjct: 238 WIATSGIS----TTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCL 293
Query: 314 PAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLTDRMV 371
PAAT PP ++GWG + PE L++ V ++ +C + Y ++ M+
Sbjct: 294 PAATQNIPPGSTAYVTGWGAQEYAGHTVPE-LRQGQVRIISNDVCNAPHSYNGAILSGML 352
Query: 372 CAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431
CAG G VD+CQGDSGGPLV E+ +F+ GIVSWG C +PGVY RVT DWI
Sbjct: 353 CAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412
Query: 432 LEAT 435
+ T
Sbjct: 413 RQQT 416
Score = 188 bits (478), Expect = 2e-47
Identities = 102/256 (39%), Positives = 136/256 (53%), Gaps = 11/256 (4%)
Query: 807 EATTHTQLPDCGLAPAALT----RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERW 862
+A + + +CG P +T RI+GG+ A G WPWQVSL L H CG L+ W
Sbjct: 163 QAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHH-CGGSLINNMW 221
Query: 863 LLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLE-RVARIYKHPFYNLYTLDYDVALLEL 921
+L+AAHCF +P+ W A G +S +L RV I H Y T + D+AL+ L
Sbjct: 222 ILTAAHCFRSNSNPRDWIATSG---ISTTFPKLRMRVRNILIHNNYKSATHENDIALVRL 278
Query: 922 AGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCR 981
V ++ + +CLP P G+ +TGWG+ G +L++ VR++S C
Sbjct: 279 ENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCN 338
Query: 982 --RFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHF 1039
Y I S MLCAG PQGGVD+C GD+GGPL + W + G+ SWG CG P
Sbjct: 339 APHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDK 398
Query: 1040 PGVYTRVAAVRGWIGQ 1055
PGVYTRV A WI Q
Sbjct: 399 PGVYTRVTAYLDWIRQ 414
Score = 175 bits (444), Expect = 2e-43
Identities = 93/247 (37%), Positives = 137/247 (55%), Gaps = 8/247 (3%)
Query: 489 LQECGARPAME--KPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCF 546
+ ECGA P + R++GG A G PWQVSL+ + H CG +++ + W+L+AAHCF
Sbjct: 170 INECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCF 229
Query: 547 NHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNK 606
R + T+ + +++ +R +++H Y + D+A++ L + + F K
Sbjct: 230 RSNS--NPRDWIATSGI-STTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTK 286
Query: 607 YIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNF 664
I VCLP A Q P G ++GWG + T PEL Q V II C+ YN
Sbjct: 287 DIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQ-GQVRIISNDVCNAPHSYNG 345
Query: 665 SLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRI 724
++ M+CAG +G VD+CQGDSGGPL E++ ++++ GIVSWG C KPGVYTR+
Sbjct: 346 AILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRV 405
Query: 725 TRLKGWI 731
T WI
Sbjct: 406 TAYLDWI 412
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 193 bits (491), Expect = 6e-49
Identities = 98/271 (36%), Positives = 145/271 (53%), Gaps = 14/271 (5%)
Query: 183 GSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAA 242
G++ A CG+ P RI GG A G++PWQ S+ H CG ++++ +W++SAA
Sbjct: 29 GAEGAEAPCGVAPQ----ARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAA 84
Query: 243 HCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPL 302
HCF + +GA L + + I+ HP Y + + D+A+L+L+ P+
Sbjct: 85 HCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPI 144
Query: 303 PFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDF-LVKPEVLQKATVELLDQALCASL 361
F R+I+P+CLPAA FP C ++GWG++ L+ P+ LQ+ V L+ + C L
Sbjct: 145 TFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCL 204
Query: 362 YG--------HSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCA 413
Y H + + MVCAGY++G D+CQGDSGGPL C G ++L GIVSWG C
Sbjct: 205 YNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC-PVEGLWYLTGIVSWGDACG 263
Query: 414 EARRPGVYARVTRLRDWILEATTKASMPLAP 444
RPGVY + WI T+ + P
Sbjct: 264 ARNRPGVYTLASSYASWIQSKVTELQPRVVP 294
Score = 189 bits (480), Expect = 1e-47
Identities = 104/255 (40%), Positives = 141/255 (55%), Gaps = 16/255 (6%)
Query: 817 CGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDP 876
CG+AP A RI GGS+A G+WPWQVS+ H CG LV+E+W+LSAAHCF
Sbjct: 37 CGVAPQA--RITGGSSAVAGQWPWQVSITYEG-VHVCGGSLVSEQWVLSAAHCFPSEHHK 93
Query: 877 KQWAAFLGTPFLSG--AEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPI 934
+ + LG L + ++ + I HP Y D+ALL+L+ P+ SR +RPI
Sbjct: 94 EAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPI 153
Query: 935 CLPEPAPRPPDGTRCVITGWGSVREGGSM--ARQLQKAAVRLLSEQTCRRFY-------- 984
CLP P+G C +TGWG V S+ + LQ+ V L+S +TC Y
Sbjct: 154 CLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEE 213
Query: 985 PVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYT 1044
P + M+CAG+ +GG D+C GD+GGPL+C G W LTG+ SWG CG + PGVYT
Sbjct: 214 PHFVQEDMVCAGYVEGGKDACQGDSGGPLSC-PVEGLWYLTGIVSWGDACGARNRPGVYT 272
Query: 1045 RVAAVRGWIGQHIQE 1059
++ WI + E
Sbjct: 273 LASSYASWIQSKVTE 287
Score = 188 bits (478), Expect = 2e-47
Identities = 98/252 (38%), Positives = 144/252 (57%), Gaps = 19/252 (7%)
Query: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCF---NH 548
CG P R+ GG A +G+ PWQVS+ H CG ++V ++W+LSAAHCF +H
Sbjct: 37 CGVAPQ----ARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHH 92
Query: 549 TKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYI 608
+ +V+ LG L L+ ++ HP Y D+A+L+L+ P+ F++YI
Sbjct: 93 KEAYEVK--LGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYI 150
Query: 609 QPVCLPLAIQKFPVGRKCMISGWGNTQEG-NATKPELLQKASVGIIDQKTCSVLYNFS-- 665
+P+CLP A FP G C ++GWG+ + P+ LQ+ V +I ++TC+ LYN
Sbjct: 151 RPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAK 210
Query: 666 ------LTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPG 719
+ + M+CAG++EG D+CQGDSGGPL+C G++YL GIVSWG C +PG
Sbjct: 211 PEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC-PVEGLWYLTGIVSWGDACGARNRPG 269
Query: 720 VYTRITRLKGWI 731
VYT + WI
Sbjct: 270 VYTLASSYASWI 281
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 192 bits (489), Expect = 1e-48
Identities = 96/239 (40%), Positives = 139/239 (58%), Gaps = 6/239 (2%)
Query: 825 TRIVGGSAAGRGEWPWQVSLWLR--RREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAF 882
TRIVGG+ + GEWPWQVSL ++ + H CG L+ +W+L+AAHCFD W +
Sbjct: 389 TRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIY 448
Query: 883 LGTPFLSGA--EGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPA 940
G LS + ++ I H Y + ++D+AL++L P+ + +PICLP
Sbjct: 449 SGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKG 508
Query: 941 PRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTC-RRFYPVQISSRMLCAGFPQ 999
T C +TGWG +E G + LQK + L++ + C +R+ +I+ RM+CAG+ +
Sbjct: 509 DTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKE 568
Query: 1000 GGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQ 1058
GG D+C GD+GGPL C+ +G W L G+TSWG GC R PGVYT+VA WI + Q
Sbjct: 569 GGKDACKGDSGGPLVCKH-NGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQ 626
Score = 189 bits (479), Expect = 2e-47
Identities = 99/252 (39%), Positives = 145/252 (57%), Gaps = 7/252 (2%)
Query: 202 RIVGGMEASPGEFPWQASLREN---KEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYV 258
RIVGG +S GE+PWQ SL+ + H CG ++I +W+++AAHCF+ W Y
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYS 449
Query: 259 GATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATH 318
G LS T +Q+ +I+ H Y + D+A+++L +PL + +P+CLP+
Sbjct: 450 GILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGD 509
Query: 319 IFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLY-GHSLTDRMVCAGYLD 377
C ++GWG+ KE ++ +LQK + L+ C Y + +T RMVCAGY +
Sbjct: 510 TSTIYTNCWVTGWGFSKEKGEIQ-NILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKE 568
Query: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTK 437
G D+C+GDSGGPLVC+ +G + L GI SWG GCA +PGVY +V DWILE T+
Sbjct: 569 GGKDACKGDSGGPLVCKH-NGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILE-KTQ 626
Query: 438 ASMPLAPTMAPA 449
+S A +PA
Sbjct: 627 SSDGKAQMQSPA 638
Score = 181 bits (459), Expect = 3e-45
Identities = 87/237 (36%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Query: 502 TRVVGGFGAASGEVPWQVSLK---EGSRHFCGATVVGDRWLLSAAHCFNHTKVEQV-RAH 557
TR+VGG ++ GE PWQVSL+ RH CG +++G +W+L+AAHCF+ ++ V R +
Sbjct: 389 TRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIY 448
Query: 558 LGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAI 617
G +L + ++ +++H Y + D+A+++L +PL + ++ +P+CLP
Sbjct: 449 SGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKG 508
Query: 618 QKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLY-NFSLTDRMICAGFL 676
+ C ++GWG ++E + +LQK ++ ++ + C Y ++ +T RM+CAG+
Sbjct: 509 DTSTIYTNCWVTGWGFSKEKGEIQ-NILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYK 567
Query: 677 EGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILE 733
EG D+C+GDSGGPL C+ G++ L GI SWG GCA+ ++PGVYT++ WILE
Sbjct: 568 EGGKDACKGDSGGPLVCKH-NGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILE 623
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 192 bits (487), Expect = 2e-48
Identities = 101/245 (41%), Positives = 147/245 (60%), Gaps = 15/245 (6%)
Query: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDP-TKWVAYVGA 260
RIVGG + S G +PWQ SLR + H CG ++++ W+++AAHCF E ++W + GA
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221
Query: 261 TYLSGSEASTVRAQVVQIVKHPLY------NADTADFDVAVLELTSPLPFGRHIQPVCLP 314
+ + Q V V H Y N++ D+A++ L+SPLP +IQPVCLP
Sbjct: 222 VAQASPHGLQLGVQAV--VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279
Query: 315 AATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHSLTDRMVC 372
AA K C ++GWG + + + VLQ+A V ++ +C A YG+ + +M C
Sbjct: 280 AAGQALVDGKICTVTGWGN-TQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFC 338
Query: 373 AGYLDGKVDSCQGDSGGPLVCEEP---SGRFFLAGIVSWGIGCAEARRPGVYARVTRLRD 429
AGY +G +D+CQGDSGGP VCE+ + R+ L GIVSWG GCA A++PGVY +V+ R+
Sbjct: 339 AGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFRE 398
Query: 430 WILEA 434
WI +A
Sbjct: 399 WIFQA 403
Score = 181 bits (459), Expect = 3e-45
Identities = 98/255 (38%), Positives = 132/255 (51%), Gaps = 13/255 (5%)
Query: 816 DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875
DCG + RIVGG G WPWQVSL H CG L++ W+L+AAHCF
Sbjct: 152 DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGA-HLCGGSLLSGDWVLTAAHCFPERNR 210
Query: 876 P-KQWAAFLGTPFLSGAEGQLERVARIYKHPFY------NLYTLDYDVALLELAGPVRRS 928
+W F G + G V + H Y N D+AL+ L+ P+ +
Sbjct: 211 VLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
Query: 929 RLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCR--RFYPV 986
++P+CLP DG C +TGWG+ + G A LQ+A V ++S C FY
Sbjct: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330
Query: 987 QISSRMLCAGFPQGGVDSCSGDAGGPLACREP---SGRWVLTGVTSWGYGCGRPHFPGVY 1043
QI +M CAG+P+GG+D+C GD+GGP C + + RW L G+ SWG GC PGVY
Sbjct: 331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390
Query: 1044 TRVAAVRGWIGQHIQ 1058
T+V+ R WI Q I+
Sbjct: 391 TKVSDFREWIFQAIK 405
Score = 181 bits (458), Expect = 4e-45
Identities = 99/259 (38%), Positives = 146/259 (56%), Gaps = 14/259 (5%)
Query: 490 QECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549
Q+CG R R+VGG + G PWQVSL+ H CG +++ W+L+AAHCF
Sbjct: 151 QDCGRRKL--PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208
Query: 550 KVEQVRAHLGTASLLGLGGSPVKIGLRRVVLH----PLYNPGILDF--DLAVLELASPLA 603
R + ++ +++G++ VV H P +P + D+A++ L+SPL
Sbjct: 209 NRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLP 268
Query: 604 FNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTC--SVL 661
+YIQPVCLP A Q G+ C ++GWGNTQ + +LQ+A V II C +
Sbjct: 269 LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQY-YGQQAGVLQEARVPIISNDVCNGADF 327
Query: 662 YNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEA---PGVFYLAGIVSWGIGCAQVKKP 718
Y + +M CAG+ EG +D+CQGDSGGP CE++ + L GIVSWG GCA +KP
Sbjct: 328 YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
Query: 719 GVYTRITRLKGWILEIMSS 737
GVYT+++ + WI + + +
Sbjct: 388 GVYTKVSDFREWIFQAIKT 406
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 192 bits (487), Expect = 2e-48
Identities = 101/245 (41%), Positives = 147/245 (60%), Gaps = 15/245 (6%)
Query: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDP-TKWVAYVGA 260
RIVGG + S G +PWQ SLR + H CG ++++ W+++AAHCF E ++W + GA
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221
Query: 261 TYLSGSEASTVRAQVVQIVKHPLY------NADTADFDVAVLELTSPLPFGRHIQPVCLP 314
+ + Q V V H Y N++ D+A++ L+SPLP +IQPVCLP
Sbjct: 222 VAQASPHGLQLGVQAV--VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279
Query: 315 AATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHSLTDRMVC 372
AA K C ++GWG + + + VLQ+A V ++ +C A YG+ + +M C
Sbjct: 280 AAGQALVDGKICTVTGWGN-TQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFC 338
Query: 373 AGYLDGKVDSCQGDSGGPLVCEEP---SGRFFLAGIVSWGIGCAEARRPGVYARVTRLRD 429
AGY +G +D+CQGDSGGP VCE+ + R+ L GIVSWG GCA A++PGVY +V+ R+
Sbjct: 339 AGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFRE 398
Query: 430 WILEA 434
WI +A
Sbjct: 399 WIFQA 403
Score = 181 bits (459), Expect = 3e-45
Identities = 98/255 (38%), Positives = 132/255 (51%), Gaps = 13/255 (5%)
Query: 816 DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875
DCG + RIVGG G WPWQVSL H CG L++ W+L+AAHCF
Sbjct: 152 DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGA-HLCGGSLLSGDWVLTAAHCFPERNR 210
Query: 876 P-KQWAAFLGTPFLSGAEGQLERVARIYKHPFY------NLYTLDYDVALLELAGPVRRS 928
+W F G + G V + H Y N D+AL+ L+ P+ +
Sbjct: 211 VLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
Query: 929 RLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCR--RFYPV 986
++P+CLP DG C +TGWG+ + G A LQ+A V ++S C FY
Sbjct: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330
Query: 987 QISSRMLCAGFPQGGVDSCSGDAGGPLACREP---SGRWVLTGVTSWGYGCGRPHFPGVY 1043
QI +M CAG+P+GG+D+C GD+GGP C + + RW L G+ SWG GC PGVY
Sbjct: 331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390
Query: 1044 TRVAAVRGWIGQHIQ 1058
T+V+ R WI Q I+
Sbjct: 391 TKVSDFREWIFQAIK 405
Score = 181 bits (458), Expect = 4e-45
Identities = 99/259 (38%), Positives = 146/259 (56%), Gaps = 14/259 (5%)
Query: 490 QECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549
Q+CG R R+VGG + G PWQVSL+ H CG +++ W+L+AAHCF
Sbjct: 151 QDCGRRKL--PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208
Query: 550 KVEQVRAHLGTASLLGLGGSPVKIGLRRVVLH----PLYNPGILDF--DLAVLELASPLA 603
R + ++ +++G++ VV H P +P + D+A++ L+SPL
Sbjct: 209 NRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLP 268
Query: 604 FNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTC--SVL 661
+YIQPVCLP A Q G+ C ++GWGNTQ + +LQ+A V II C +
Sbjct: 269 LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQY-YGQQAGVLQEARVPIISNDVCNGADF 327
Query: 662 YNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEA---PGVFYLAGIVSWGIGCAQVKKP 718
Y + +M CAG+ EG +D+CQGDSGGP CE++ + L GIVSWG GCA +KP
Sbjct: 328 YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
Query: 719 GVYTRITRLKGWILEIMSS 737
GVYT+++ + WI + + +
Sbjct: 388 GVYTKVSDFREWIFQAIKT 406
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 192 bits (487), Expect = 2e-48
Identities = 111/250 (44%), Positives = 136/250 (54%), Gaps = 16/250 (6%)
Query: 817 CGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDP 876
CG P +RIVGG GEWPWQ S+ R H CG L+A +W+L+AAHCF P
Sbjct: 28 CG-QPRMSSRIVGGRDGRDGEWPWQASIQ-HRGAHVCGGSLIAPQWVLTAAHCFPRRALP 85
Query: 877 KQWAAFLGTPFLSGAEGQLERVA--RIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPI 934
++ LG L + V R+ P Y+ D+ALL+L PV S V+P+
Sbjct: 86 AEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPV 145
Query: 935 CLPEPAPRPPDGTRCVITGWGSVREGGSMA--RQLQKAAVRLLSEQTCRRFYPVQ----- 987
CLP P RPP GT C +TGWGS+R G + R LQ V LL +TC Y V
Sbjct: 146 CLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQ 205
Query: 988 ----ISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVY 1043
+ LCAG+PQG D+C GD+GGPL C + SG WVL GV SWG GC P+ PGVY
Sbjct: 206 AERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQ-SGSWVLVGVVSWGKGCALPNRPGVY 264
Query: 1044 TRVAAVRGWI 1053
T VA WI
Sbjct: 265 TSVATYSPWI 274
Score = 184 bits (468), Expect = 3e-46
Identities = 104/251 (41%), Positives = 139/251 (55%), Gaps = 14/251 (5%)
Query: 191 CGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQD 250
CG QP RM+ RIVGG + GE+PWQAS++ H CG ++I +W+++AAHCF
Sbjct: 28 CG-QP--RMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRAL 84
Query: 251 PTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQP 310
P ++ +GA L + T+ V +++ P Y+ D A D+A+L+L P+P +QP
Sbjct: 85 PAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQP 144
Query: 311 VCLPAATHIFPPSKKCLISGWGYLKEDF-LVKPEVLQKATVELLDQALCASLYGHSL--- 366
VCLP PP C ++GWG L+ L + LQ V LLD C LY
Sbjct: 145 VCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVP 204
Query: 367 -TDRMV-----CAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGV 420
+R+V CAGY G D+CQGDSGGPL C + SG + L G+VSWG GCA RPGV
Sbjct: 205 QAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQ-SGSWVLVGVVSWGKGCALPNRPGV 263
Query: 421 YARVTRLRDWI 431
Y V WI
Sbjct: 264 YTSVATYSPWI 274
Score = 172 bits (437), Expect = 1e-42
Identities = 97/256 (37%), Positives = 142/256 (55%), Gaps = 17/256 (6%)
Query: 488 KLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFN 547
K CG +P M +R+VGG GE PWQ S++ H CG +++ +W+L+AAHCF
Sbjct: 24 KSAACG-QPRMS--SRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFP 80
Query: 548 HTKVE-QVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNK 606
+ + R LG L + + +RRV+L P Y+ DLA+L+L P+ +
Sbjct: 81 RRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSA 140
Query: 607 YIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPEL--LQKASVGIIDQKTCSVLYNF 664
+QPVCLP+ + P G C ++GWG+ + G PE LQ V ++D +TC LY+
Sbjct: 141 RVQPVCLPVPGARPPPGTPCRVTGWGSLRPG-VPLPEWRPLQGVRVPLLDSRTCDGLYHV 199
Query: 665 SL----TDRMI-----CAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQV 715
+R++ CAG+ +G D+CQGDSGGPL C ++ G + L G+VSWG GCA
Sbjct: 200 GADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQS-GSWVLVGVVSWGKGCALP 258
Query: 716 KKPGVYTRITRLKGWI 731
+PGVYT + WI
Sbjct: 259 NRPGVYTSVATYSPWI 274
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 191 bits (485), Expect = 3e-48
Identities = 104/247 (42%), Positives = 148/247 (59%), Gaps = 8/247 (3%)
Query: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC-FNHTK 550
CG R +R+VGG + + PWQ SL+ H CG +V+ W+++AAHC ++
Sbjct: 207 CGHRRGYS--SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYL 264
Query: 551 VEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQP 610
+ +G SLL +P + + ++V H Y P L D+A+++LA PL FN+ IQP
Sbjct: 265 PKSWTIQVGLVSLLD-NPAPSHL-VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQP 322
Query: 611 VCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCS--VLYNFSLTD 668
VCLP + + FP G+ C SGWG T++G +L A+V +I K C+ +Y ++
Sbjct: 323 VCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 382
Query: 669 RMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLK 728
M+CAG+L G VDSCQGDSGGPL C+E ++ L G S+GIGCA+V KPGVYTR+T
Sbjct: 383 SMLCAGYLTGGVDSCQGDSGGPLVCQER-RLWKLVGATSFGIGCAEVNKPGVYTRVTSFL 441
Query: 729 GWILEIM 735
WI E M
Sbjct: 442 DWIHEQM 448
Score = 191 bits (484), Expect = 4e-48
Identities = 102/236 (43%), Positives = 133/236 (56%), Gaps = 5/236 (2%)
Query: 200 AGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVG 259
+ RIVGG + ++PWQASL+ H CG ++I W+++AAHC + P W VG
Sbjct: 214 SSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVG 273
Query: 260 ATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHI 319
L + A + V +IV H Y D+A+++L PL F IQPVCLP +
Sbjct: 274 LVSLLDNPAPS--HLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEEN 331
Query: 320 FPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHSLTDRMVCAGYLD 377
FP K C SGWG ++ VL A V L+ +C +YG ++ M+CAGYL
Sbjct: 332 FPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLT 391
Query: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILE 433
G VDSCQGDSGGPLVC+E + L G S+GIGCAE +PGVY RVT DWI E
Sbjct: 392 GGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHE 446
Score = 182 bits (461), Expect = 2e-45
Identities = 101/250 (40%), Positives = 139/250 (55%), Gaps = 7/250 (2%)
Query: 813 QLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHC-FD 871
Q CG +RIVGG+ + +WPWQ SL + H CG ++ W+++AAHC +D
Sbjct: 203 QCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGY-HLCGGSVITPLWIITAAHCVYD 261
Query: 872 VYGDPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLV 931
+Y PK W +G L V +I H Y L D+AL++LAGP+ + ++
Sbjct: 262 LYL-PKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMI 320
Query: 932 RPICLPEPAPRPPDGTRCVITGWGSVREG-GSMARQLQKAAVRLLSEQTC--RRFYPVQI 988
+P+CLP PDG C +GWG+ +G G + L AAV L+S + C R Y I
Sbjct: 321 QPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGII 380
Query: 989 SSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAA 1048
S MLCAG+ GGVDSC GD+GGPL C+E W L G TS+G GC + PGVYTRV +
Sbjct: 381 SPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTS 439
Query: 1049 VRGWIGQHIQ 1058
WI + ++
Sbjct: 440 FLDWIHEQME 449
>gi|148613878 acrosin precursor [Homo sapiens]
Length = 421
Score = 191 bits (484), Expect = 4e-48
Identities = 111/305 (36%), Positives = 161/305 (52%), Gaps = 25/305 (8%)
Query: 185 DEAHCE--CGLQPAWRMAG--RIVGGMEASPGEFPWQASLR-----ENKEHFCGAAIINA 235
D A C+ CGL+ G RIVGG A G +PW SL+ ++ H CG +++N+
Sbjct: 21 DNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNS 80
Query: 236 RWLVSAAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQ-----VVQIVKHPLYNADTAD 290
RW+++AAHCF + W GA ++ V+A V +I+ H YN+ T
Sbjct: 81 RWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEG 140
Query: 291 FDVAVLELTSPLPFGRHIQPVCLPAATHIFPP-SKKCLISGWGYLKEDFLVKPEVLQKAT 349
D+A++E+T P+ GR I P CLP P S+ C ++GWGY++E +L +A
Sbjct: 141 NDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEAR 200
Query: 350 VELLDQALCASL--YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEE-PSGRFFLAGIV 406
V+L+D LC S Y + VCAGY GK+D+CQGDSGGPL+C++ + + GI
Sbjct: 201 VDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGIT 260
Query: 407 SWGIGCAEARRPGVYARVTRLRDWILE-------ATTKASMPLAPTMAPAPAAPSTAWPT 459
SWG+GCA A+RPG+Y +WI +++ P PT P P P + P
Sbjct: 261 SWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPI 320
Query: 460 SPESP 464
S P
Sbjct: 321 SAHLP 325
Score = 172 bits (437), Expect = 1e-42
Identities = 112/338 (33%), Positives = 161/338 (47%), Gaps = 25/338 (7%)
Query: 503 RVVGGFGAASGEVPWQVSLK-----EGSRHFCGATVVGDRWLLSAAHCF-NHTKVEQVRA 556
R+VGG A G PW VSL+ H CG +++ RW+L+AAHCF V R
Sbjct: 42 RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
Query: 557 HLGTASLLGLGGSPVKIGLR-----RVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPV 611
G + PVK L+ ++++H YN D+A++E+ P++ ++I P
Sbjct: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
Query: 612 CLPLAIQKFPVG-RKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVL--YNFSLTD 668
CLP P G + C ++GWG +E +L +A V +ID C+ YN +
Sbjct: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
Query: 669 RMICAGFLEGKVDSCQGDSGGPLACEEA-PGVFYLAGIVSWGIGCAQVKKPGVYTRITRL 727
+CAG+ GK+D+CQGDSGGPL C+++ + + GI SWG+GCA+ K+PG+YT
Sbjct: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
Query: 728 KGWILEIMSSQPLPM-----SPPSTTRMLATTSPRT---TAGLTVPGATPSRPTPGAASR 779
WI + S L M PP TTR P + +A L P RP P
Sbjct: 282 LNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPA 341
Query: 780 VTGQPANSTLSAVSTTARGQTPFPDAPEAT--THTQLP 815
+P S A P P P T + T+LP
Sbjct: 342 AQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLP 379
Score = 159 bits (403), Expect = 1e-38
Identities = 93/261 (35%), Positives = 127/261 (48%), Gaps = 20/261 (7%)
Query: 817 CGLA----PAALTRIVGGSAAGRGEWPWQVSLWL----RRREHRCGAVLVAERWLLSAAH 868
CGL P RIVGG AA G WPW VSL + R H CG L+ RW+L+AAH
Sbjct: 29 CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
Query: 869 CFDVYGDPKQWAAFLGTPFLSGAEG-------QLERVARIYKHPFYNLYTLDYDVALLEL 921
CF + W G ++ Q V +I H YN T D+AL+E+
Sbjct: 89 CFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEI 148
Query: 922 AGPVRRSRLVRPICLPEPAPRPPDGTR-CVITGWGSVREGGSMARQ-LQKAAVRLLSEQT 979
P+ R + P CLP P G++ C + GWG + E L +A V L+
Sbjct: 149 TPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDL 208
Query: 980 CR--RFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACRE-PSGRWVLTGVTSWGYGCGR 1036
C ++Y ++ +CAG+P G +D+C GD+GGPL C++ +V+ G+TSWG GC R
Sbjct: 209 CNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCAR 268
Query: 1037 PHFPGVYTRVAAVRGWIGQHI 1057
PG+YT WI I
Sbjct: 269 AKRPGIYTATWPYLNWIASKI 289
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 189 bits (481), Expect = 9e-48
Identities = 103/244 (42%), Positives = 138/244 (56%), Gaps = 6/244 (2%)
Query: 191 CGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNE-FQ 249
CG+ RIVGG A PG +PWQ SL H CG +II W+V+AAHC +
Sbjct: 281 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLN 340
Query: 250 DPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQ 309
+P W A+ G S QV +++ HP Y++ T + D+A+++L PL F ++
Sbjct: 341 NPWHWTAFAGILRQSFMFYG-AGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVK 399
Query: 310 PVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLT 367
PVCLP + P + C ISGWG +E EVL A V L++ C S +Y + +T
Sbjct: 400 PVCLPNPGMMLQPEQLCWISGWGATEEKGKTS-EVLNAAKVLLIETQRCNSRYVYDNLIT 458
Query: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427
M+CAG+L G VDSCQGDSGGPLV + + ++L G SWG GCA+A RPGVY V
Sbjct: 459 PAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 517
Query: 428 RDWI 431
DWI
Sbjct: 518 TDWI 521
Score = 174 bits (440), Expect = 5e-43
Identities = 101/246 (41%), Positives = 135/246 (54%), Gaps = 14/246 (5%)
Query: 817 CG--LAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV-Y 873
CG L + +RIVGG +A G WPWQVSL ++ H CG ++ W+++AAHC +
Sbjct: 281 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQN-VHVCGGSIITPEWIVTAAHCVEKPL 339
Query: 874 GDPKQWAAFLGTPFLS----GAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSR 929
+P W AF G S GA Q+E+V HP Y+ T + D+AL++L P+ +
Sbjct: 340 NNPWHWTAFAGILRQSFMFYGAGYQVEKVI---SHPNYDSKTKNNDIALMKLQKPLTFND 396
Query: 930 LVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTC--RRFYPVQ 987
LV+P+CLP P C I+GWG+ E G + L A V L+ Q C R Y
Sbjct: 397 LVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL 456
Query: 988 ISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVA 1047
I+ M+CAGF QG VDSC GD+GGPL + + W L G TSWG GC + + PGVY V
Sbjct: 457 ITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVM 515
Query: 1048 AVRGWI 1053
WI
Sbjct: 516 VFTDWI 521
Score = 168 bits (426), Expect = 2e-41
Identities = 94/250 (37%), Positives = 136/250 (54%), Gaps = 11/250 (4%)
Query: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC----FN 547
CG + +R+VGG A G PWQVSL + H CG +++ W+++AAHC N
Sbjct: 281 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLN 340
Query: 548 HTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607
+ A + S + G + +V+ HP Y+ + D+A+++L PL FN
Sbjct: 341 NPWHWTAFAGILRQSFMFYGAG---YQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 397
Query: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCS--VLYNFS 665
++PVCLP + C ISGWG T+E T E+L A V +I+ + C+ +Y+
Sbjct: 398 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTS-EVLNAAKVLLIETQRCNSRYVYDNL 456
Query: 666 LTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRIT 725
+T MICAGFL+G VDSCQGDSGGPL + +++L G SWG GCA+ +PGVY +
Sbjct: 457 ITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVM 515
Query: 726 RLKGWILEIM 735
WI M
Sbjct: 516 VFTDWIYRQM 525
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 189 bits (481), Expect = 9e-48
Identities = 103/244 (42%), Positives = 138/244 (56%), Gaps = 6/244 (2%)
Query: 191 CGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNE-FQ 249
CG+ RIVGG A PG +PWQ SL H CG +II W+V+AAHC +
Sbjct: 244 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLN 303
Query: 250 DPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQ 309
+P W A+ G S QV +++ HP Y++ T + D+A+++L PL F ++
Sbjct: 304 NPWHWTAFAGILRQSFMFYG-AGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVK 362
Query: 310 PVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLT 367
PVCLP + P + C ISGWG +E EVL A V L++ C S +Y + +T
Sbjct: 363 PVCLPNPGMMLQPEQLCWISGWGATEEKGKTS-EVLNAAKVLLIETQRCNSRYVYDNLIT 421
Query: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427
M+CAG+L G VDSCQGDSGGPLV + + ++L G SWG GCA+A RPGVY V
Sbjct: 422 PAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480
Query: 428 RDWI 431
DWI
Sbjct: 481 TDWI 484
Score = 174 bits (440), Expect = 5e-43
Identities = 101/246 (41%), Positives = 135/246 (54%), Gaps = 14/246 (5%)
Query: 817 CG--LAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV-Y 873
CG L + +RIVGG +A G WPWQVSL ++ H CG ++ W+++AAHC +
Sbjct: 244 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQN-VHVCGGSIITPEWIVTAAHCVEKPL 302
Query: 874 GDPKQWAAFLGTPFLS----GAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSR 929
+P W AF G S GA Q+E+V HP Y+ T + D+AL++L P+ +
Sbjct: 303 NNPWHWTAFAGILRQSFMFYGAGYQVEKVI---SHPNYDSKTKNNDIALMKLQKPLTFND 359
Query: 930 LVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTC--RRFYPVQ 987
LV+P+CLP P C I+GWG+ E G + L A V L+ Q C R Y
Sbjct: 360 LVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL 419
Query: 988 ISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVA 1047
I+ M+CAGF QG VDSC GD+GGPL + + W L G TSWG GC + + PGVY V
Sbjct: 420 ITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVM 478
Query: 1048 AVRGWI 1053
WI
Sbjct: 479 VFTDWI 484
Score = 168 bits (426), Expect = 2e-41
Identities = 94/250 (37%), Positives = 136/250 (54%), Gaps = 11/250 (4%)
Query: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC----FN 547
CG + +R+VGG A G PWQVSL + H CG +++ W+++AAHC N
Sbjct: 244 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLN 303
Query: 548 HTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607
+ A + S + G + +V+ HP Y+ + D+A+++L PL FN
Sbjct: 304 NPWHWTAFAGILRQSFMFYGAG---YQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360
Query: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCS--VLYNFS 665
++PVCLP + C ISGWG T+E T E+L A V +I+ + C+ +Y+
Sbjct: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTS-EVLNAAKVLLIETQRCNSRYVYDNL 419
Query: 666 LTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRIT 725
+T MICAGFL+G VDSCQGDSGGPL + +++L G SWG GCA+ +PGVY +
Sbjct: 420 ITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVM 478
Query: 726 RLKGWILEIM 735
WI M
Sbjct: 479 VFTDWIYRQM 488
>gi|11545839 protease, serine, 22 [Homo sapiens]
Length = 317
Score = 189 bits (481), Expect = 9e-48
Identities = 91/238 (38%), Positives = 145/238 (60%), Gaps = 9/238 (3%)
Query: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNE-FQDPTKWVAYVGA 260
R+VGG +++ E+PW S+++N H C +++ +RW+++AAHCF + P + +GA
Sbjct: 49 RVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA 108
Query: 261 TYLSGSEASTVRAQVVQIVKHPLYN-ADTADFDVAVLELTSPLPFGRHIQPVCLPAATHI 319
L + + + V + HP+Y+ + A D+A++ L + F + P+CLP A+
Sbjct: 109 WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIH 168
Query: 320 FPPSKKCLISGWGYLKEDF-LVKPEVLQKATVELLDQALCASLYGHS-----LTDRMVCA 373
PP+ C ISGWG +++ L P+ LQK V ++D +C+ LY +T+ M+CA
Sbjct: 169 LPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCA 228
Query: 374 GYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431
GYL+G+ D+C GDSGGPL+C + G + LAGI+SWG GCAE RPGVY ++ R W+
Sbjct: 229 GYLEGERDACLGDSGGPLMC-QVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWV 285
Score = 181 bits (459), Expect = 3e-45
Identities = 107/285 (37%), Positives = 157/285 (55%), Gaps = 15/285 (5%)
Query: 466 VSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGS 525
+ T T + ST L+ +P CG +P ++ RVVGG + E PW VS+++
Sbjct: 15 LGTFTSLLLLASTAILNAARIPVPPACG-KP--QQLNRVVGGEDSTDSEWPWIVSIQKNG 71
Query: 526 RHFCGATVVGDRWLLSAAHCF--NHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPL 583
H C +++ RW+++AAHCF N K LG L G K+G+ V HP+
Sbjct: 72 THHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPV 131
Query: 584 YN--PGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEG-NAT 640
Y+ G D+A++ L + F++ + P+CLP A P C ISGWG+ Q+G
Sbjct: 132 YSWKEGAC-ADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLP 190
Query: 641 KPELLQKASVGIIDQKTCSVLY-----NFSLTDRMICAGFLEGKVDSCQGDSGGPLACEE 695
P+ LQK V IID + CS LY +T+ M+CAG+LEG+ D+C GDSGGPL C +
Sbjct: 191 HPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMC-Q 249
Query: 696 APGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSSQPL 740
G + LAGI+SWG GCA+ +PGVY ++ + W+ +I+ L
Sbjct: 250 VDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQL 294
Score = 168 bits (426), Expect = 2e-41
Identities = 96/255 (37%), Positives = 138/255 (54%), Gaps = 14/255 (5%)
Query: 815 PDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCF-DVY 873
P CG P L R+VGG + EWPW VS+ + H C L+ RW+++AAHCF D
Sbjct: 39 PACG-KPQQLNRVVGGEDSTDSEWPWIVSIQ-KNGTHHCAGSLLTSRWVITAAHCFKDNL 96
Query: 874 GDPKQWAAFLGTPFLS--GAEGQLERVARIYKHPFYNLYT-LDYDVALLELAGPVRRSRL 930
P ++ LG L G+ Q VA + HP Y+ D+AL+ L ++ S
Sbjct: 97 NKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSER 156
Query: 931 VRPICLPEPAPRPPDGTRCVITGWGSVREGGSM--ARQLQKAAVRLLSEQTCRRFY---- 984
V PICLP+ + P T C I+GWGS+++G + + LQK V ++ + C Y
Sbjct: 157 VLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGA 216
Query: 985 -PVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVY 1043
I+ MLCAG+ +G D+C GD+GGPL C + G W+L G+ SWG GC + PGVY
Sbjct: 217 GQGPITEDMLCAGYLEGERDACLGDSGGPLMC-QVDGAWLLAGIISWGEGCAERNRPGVY 275
Query: 1044 TRVAAVRGWIGQHIQ 1058
++A R W+ + +Q
Sbjct: 276 ISLSAHRSWVEKIVQ 290
>gi|110815798 ovochymase 1 [Homo sapiens]
Length = 1134
Score = 189 bits (480), Expect = 1e-47
Identities = 110/313 (35%), Positives = 163/313 (52%), Gaps = 20/313 (6%)
Query: 164 SQCVTKVNPECDDQED-CSDGSDEAHCECGL---QPAWRMAGRIVGGMEASPGEFPWQAS 219
S+ + K P+ Q + S H CG+ P W ++ RI GG EA P +PWQ
Sbjct: 533 SESLNKFEPKLPPQNNPVSTVKAILHDVCGIPPFSPQW-LSRRIAGGEEACPHCWPWQVG 591
Query: 220 LRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIV 279
LR ++ CG AIIN W+++AAHC +P W G + E++ + I+
Sbjct: 592 LRFLGDYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAGDHDRNLKESTEQVRRAKHII 651
Query: 280 KHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFL 339
H +N + D D+A+++L+SPL + ++PVCLP + S+ C ++GWG + D
Sbjct: 652 VHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSEICAVTGWGSISADGG 711
Query: 340 VKPEVLQKATVELLDQALCASLY--GH--SLTDRMVCAGY-LDGKVDSCQGDSGGPLVCE 394
+ LQ+ V +L++ +C Y H +T++M+CAG+ G+ D CQGDSGGPLVC
Sbjct: 712 LASR-LQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGFAASGEKDFCQGDSGGPLVCR 770
Query: 395 EPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI---------LEATTKASMPLAPT 445
+G F L GIVSWG GC + +PGV+ARV DWI L+ K
Sbjct: 771 HENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQSKINGPASLQTNNKCKTLKQQL 830
Query: 446 MAPAPAAPSTAWP 458
P P+ S +WP
Sbjct: 831 PPPTPSPDSASWP 843
Score = 179 bits (455), Expect = 9e-45
Identities = 103/294 (35%), Positives = 150/294 (51%), Gaps = 15/294 (5%)
Query: 778 SRVTGQPANSTLSAVSTTARGQTPFP--DAPEATTHTQLPD-CGLAPAA----LTRIVGG 830
+R+ G A T+ + + + P + P +T L D CG+ P + RI GG
Sbjct: 519 NRLQGFKARFTILPSESLNKFEPKLPPQNNPVSTVKAILHDVCGIPPFSPQWLSRRIAGG 578
Query: 831 SAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPF--L 888
A WPWQV L +++CG ++ W+L+AAHC + +P W G L
Sbjct: 579 EEACPHCWPWQVGLRFLG-DYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAGDHDRNL 637
Query: 889 SGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTR 948
+ Q+ R I H +N + D D+AL++L+ P+ + +VRP+CLP A
Sbjct: 638 KESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSEI 697
Query: 949 CVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFY----PVQISSRMLCAGFPQGG-VD 1003
C +TGWGS+ G +A +LQ+ V +L + C Y P I+ +M+CAGF G D
Sbjct: 698 CAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGFAASGEKD 757
Query: 1004 SCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHI 1057
C GD+GGPL CR +G +VL G+ SWG GC +P PGV+ RV WI I
Sbjct: 758 FCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQSKI 811
Score = 149 bits (375), Expect = 2e-35
Identities = 87/253 (34%), Positives = 128/253 (50%), Gaps = 19/253 (7%)
Query: 492 CGARPAMEK--PTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549
CG P + R+ GG A PWQV L+ + CG ++ W+L+AAHC
Sbjct: 561 CGIPPFSPQWLSRRIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHC---- 616
Query: 550 KVEQVRAHLGTASLLGLGGSPVKIGLRRV------VLHPLYNPGILDFDLAVLELASPLA 603
V+ L + G +K +V ++H +N D D+A+++L+SPL
Sbjct: 617 -VQLKNNPLSWTIIAGDHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLE 675
Query: 604 FNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYN 663
+N ++PVCLP + + C ++GWG+ L Q+ V +++++ C Y
Sbjct: 676 YNSVVRPVCLPHSAEPLFSSEICAVTGWGSISADGGLASRL-QQIQVHVLEREVCEHTYY 734
Query: 664 FS----LTDRMICAGFL-EGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKP 718
+ +T++MICAGF G+ D CQGDSGGPL C G F L GIVSWG GC Q KP
Sbjct: 735 SAHPGGITEKMICAGFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKP 794
Query: 719 GVYTRITRLKGWI 731
GV+ R+ WI
Sbjct: 795 GVFARVMIFLDWI 807
Score = 140 bits (352), Expect = 8e-33
Identities = 85/253 (33%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 198 RMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPT-KWVA 256
R RI ++ PWQ SL+ ++ HFCG ++I +V+AAHC + + K +
Sbjct: 42 RFFSRISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNIT 101
Query: 257 YVGATY-LSGSEASTVRAQVVQIVKHPLYNA-DTADFDVAVLELTSPLPFGRHIQPVCLP 314
Y L + V +I+ HP YN+ + D+A+L L + FG +QP+CLP
Sbjct: 102 VTSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLP 161
Query: 315 AATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC----ASLYGHSLTDRM 370
+ P CL SGWG + + VLQ+ + ++D C S+ L M
Sbjct: 162 DSDDKVEPGILCLSSGWGKISKTSEYS-NVLQEMELPIMDDRACNTVLKSMNLPPLGRTM 220
Query: 371 VCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRP----------GV 420
+CAG+ D +D+CQGDSGGPLVC G + LAGI SW GCA P G+
Sbjct: 221 LCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGI 280
Query: 421 YARVTRLRDWILE 433
+++V+ L D+I +
Sbjct: 281 FSKVSELMDFITQ 293
Score = 139 bits (349), Expect = 2e-32
Identities = 79/236 (33%), Positives = 126/236 (53%), Gaps = 19/236 (8%)
Query: 516 PWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVR---AHLGTASLLGLGGSPVK 572
PWQVSLK HFCG +++ + +++AAHC + +Q++ G SL
Sbjct: 59 PWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKDKQEQN 118
Query: 573 IGLRRVVLHPLYNPG-ILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGW 631
I + +++ HP YN + D+A+L L + F +QP+CLP + K G C+ SGW
Sbjct: 119 IPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLPDSDDKVEPGILCLSSGW 178
Query: 632 GNTQEGNATKPELLQKASVGIIDQKTCS-VLYNFSLTD---RMICAGFLEGKVDSCQGDS 687
G + + +LQ+ + I+D + C+ VL + +L M+CAGF + +D+CQGDS
Sbjct: 179 GKISK-TSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGDS 237
Query: 688 GGPLACEEAPGVFYLAGIVSWGIGCAQVKKP----------GVYTRITRLKGWILE 733
GGPL C G++ LAGI SW GCA P G++++++ L +I +
Sbjct: 238 GGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGIFSKVSELMDFITQ 293
Score = 133 bits (335), Expect = 8e-31
Identities = 79/239 (33%), Positives = 119/239 (49%), Gaps = 22/239 (9%)
Query: 839 PWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTP-----FLSGAEG 893
PWQVSL H CG L+ E +++AAHC D + KQ T F +
Sbjct: 59 PWQVSL-KSDEHHFCGGSLIQEDRVVTAAHCLDSLSE-KQLKNITVTSGEYSLFQKDKQE 116
Query: 894 QLERVARIYKHPFYNLYT-LDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVIT 952
Q V++I HP YN + D+ALL L V+ V+PICLP+ + G C+ +
Sbjct: 117 QNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLPDSDDKVEPGILCLSS 176
Query: 953 GWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQ----ISSRMLCAGFPQGGVDSCSGD 1008
GWG + + + LQ+ + ++ ++ C + MLCAGFP G+D+C GD
Sbjct: 177 GWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGD 236
Query: 1009 AGGPLACREPSGRWVLTGVTSWGYGCGRPHFP----------GVYTRVAAVRGWIGQHI 1057
+GGPL CR G W+L G+TSW GC P G++++V+ + +I Q++
Sbjct: 237 SGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGIFSKVSELMDFITQNL 295
>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
Length = 438
Score = 186 bits (471), Expect = 1e-46
Identities = 99/245 (40%), Positives = 153/245 (62%), Gaps = 10/245 (4%)
Query: 195 PAWRMAGRIVGGME-ASPGEFPWQASLRE-NKEHFCGAAIINARWLVSAAHCFNEFQDPT 252
PA RIV G E A GE+PWQASL+ H CGA++I+ WL++AAHCF + +DPT
Sbjct: 198 PASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPT 257
Query: 253 KWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVC 312
+W+A GAT V+ V +I+ H Y+ +T + D+A+++L++ + F +Q VC
Sbjct: 258 QWIATFGATI----TPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVC 313
Query: 313 LPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHSLTDRM 370
LP ++ PP ++G+G + +D ++ L++A VE + +C +Y +T M
Sbjct: 314 LPDSSIKLPPKTSVFVTGFGSIVDDGPIQ-NTLRQARVETISTDVCNRKDVYDGLITPGM 372
Query: 371 VCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDW 430
+CAG+++GK+D+C+GDSGGPLV + +++ GIVSWG CA ++PGVY RVT+ RDW
Sbjct: 373 LCAGFMEGKIDACKGDSGGPLVYDN-HDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431
Query: 431 ILEAT 435
I T
Sbjct: 432 IASKT 436
Score = 178 bits (452), Expect = 2e-44
Identities = 97/237 (40%), Positives = 133/237 (56%), Gaps = 6/237 (2%)
Query: 820 APAALTRIVGG-SAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQ 878
A ++ RIV G A GEWPWQ SL L H+CGA L++ WLL+AAHCF DP Q
Sbjct: 199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQ 258
Query: 879 WAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPE 938
W A G A + V +I H Y+ T + D+AL++L+ V S +V+ +CLP+
Sbjct: 259 WIATFGATITPPAVKR--NVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPD 316
Query: 939 PAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRR--FYPVQISSRMLCAG 996
+ + P T +TG+GS+ + G + L++A V +S C R Y I+ MLCAG
Sbjct: 317 SSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAG 376
Query: 997 FPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
F +G +D+C GD+GGPL + W + G+ SWG C P PGVYTRV R WI
Sbjct: 377 FMEGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
Score = 162 bits (411), Expect = 1e-39
Identities = 94/241 (39%), Positives = 142/241 (58%), Gaps = 11/241 (4%)
Query: 496 PAMEKPTRVVGGFGAA-SGEVPWQVSLKE-GSRHFCGATVVGDRWLLSAAHCFNHTK-VE 552
PA R+V G A GE PWQ SL+ GS H CGA+++ + WLL+AAHCF K
Sbjct: 198 PASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPT 257
Query: 553 QVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVC 612
Q A G + VK +R+++LH Y+ + D+A+++L++ + F+ +Q VC
Sbjct: 258 QWIATFGAT----ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVC 313
Query: 613 LPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSLTDRM 670
LP + K P ++G+G+ + + L++A V I C+ +Y+ +T M
Sbjct: 314 LPDSSIKLPPKTSVFVTGFGSIVDDGPIQ-NTLRQARVETISTDVCNRKDVYDGLITPGM 372
Query: 671 ICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGW 730
+CAGF+EGK+D+C+GDSGGPL + ++Y+ GIVSWG CA KKPGVYTR+T+ + W
Sbjct: 373 LCAGFMEGKIDACKGDSGGPLVYDNHD-IWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431
Query: 731 I 731
I
Sbjct: 432 I 432
>gi|21614531 testisin isoform 2 [Homo sapiens]
Length = 312
Score = 184 bits (467), Expect = 4e-46
Identities = 97/271 (35%), Positives = 150/271 (55%), Gaps = 23/271 (8%)
Query: 199 MAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFN-EFQDPTKWVAY 257
+ RIVGG +A G +PWQ SLR H CG ++++ RW ++AAHCF + DP+ W+
Sbjct: 38 ITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQ 97
Query: 258 VGATYLSGS----EASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCL 313
G S +A R V I P Y ++ +D+A+++L++P+ + +HIQP+CL
Sbjct: 98 FGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSP-YDIALVKLSAPVTYTKHIQPICL 156
Query: 314 PAATHIFPPSKKCLISGWGYLKED-FLVKPEVLQKATVELLDQALCASL-----YGHSLT 367
A+T F C ++GWGY+KED L P LQ+ V +++ ++C L + +
Sbjct: 157 QASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIF 216
Query: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427
MVCAG G D+C GDSGGPL C + +G ++ G+VSWG+GC RPGVY ++
Sbjct: 217 GDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPGVYTNISHH 275
Query: 428 RDWILEATTKASMPLAPTMAPAPAAPSTAWP 458
+WI + ++ M + P +WP
Sbjct: 276 FEWIQKLMAQSGM----------SQPDPSWP 296
Score = 166 bits (421), Expect = 8e-41
Identities = 97/243 (39%), Positives = 131/243 (53%), Gaps = 17/243 (6%)
Query: 825 TRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV-YGDPKQWAAFL 883
+RIVGG A G WPWQ SL L H CG L++ RW L+AAHCF+ DP W
Sbjct: 40 SRIVGGEDAELGRWPWQGSLRLWD-SHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQF 98
Query: 884 GT----PFLSGAEGQLER--VARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLP 937
G P + R V+ IY P Y L YD+AL++L+ PV ++ ++PICL
Sbjct: 99 GQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQPICLQ 157
Query: 938 EPAPRPPDGTRCVITGWGSVREGGSMA--RQLQKAAVRLLSEQTCRRFY-----PVQISS 990
+ T C +TGWG ++E ++ LQ+ V +++ C + I
Sbjct: 158 ASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFG 217
Query: 991 RMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVR 1050
M+CAG QGG D+C GD+GGPLAC + +G W GV SWG GCGRP+ PGVYT ++
Sbjct: 218 DMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPGVYTNISHHF 276
Query: 1051 GWI 1053
WI
Sbjct: 277 EWI 279
Score = 164 bits (416), Expect = 3e-40
Identities = 95/267 (35%), Positives = 142/267 (53%), Gaps = 17/267 (6%)
Query: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKV 551
CG R +R+VGG A G PWQ SL+ H CG +++ RW L+AAHCF
Sbjct: 33 CGRRVIT---SRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLS 89
Query: 552 E------QVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFN 605
+ Q S L + + + L P Y G +D+A+++L++P+ +
Sbjct: 90 DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYT 148
Query: 606 KYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNA-TKPELLQKASVGIIDQKTCSVL--- 661
K+IQP+CL + +F C ++GWG +E A P LQ+ V II+ C+ L
Sbjct: 149 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 208
Query: 662 YNF--SLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPG 719
Y+F + M+CAG +G D+C GDSGGPLAC + G++Y G+VSWG+GC + +PG
Sbjct: 209 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPG 267
Query: 720 VYTRITRLKGWILEIMSSQPLPMSPPS 746
VYT I+ WI ++M+ + PS
Sbjct: 268 VYTNISHHFEWIQKLMAQSGMSQPDPS 294
>gi|5803197 testisin isoform 1 [Homo sapiens]
Length = 314
Score = 184 bits (466), Expect = 5e-46
Identities = 97/273 (35%), Positives = 150/273 (54%), Gaps = 25/273 (9%)
Query: 199 MAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF---NEFQDPTKWV 255
+ RIVGG +A G +PWQ SLR H CG ++++ RW ++AAHCF ++ DP+ W+
Sbjct: 38 ITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWM 97
Query: 256 AYVGATYLSGS----EASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPV 311
G S +A R V I P Y + +D+A+++L++P+ + +HIQP+
Sbjct: 98 VQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQPI 156
Query: 312 CLPAATHIFPPSKKCLISGWGYLKED-FLVKPEVLQKATVELLDQALCASL-----YGHS 365
CL A+T F C ++GWGY+KED L P LQ+ V +++ ++C L +
Sbjct: 157 CLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKD 216
Query: 366 LTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVT 425
+ MVCAG G D+C GDSGGPL C + +G ++ G+VSWG+GC RPGVY ++
Sbjct: 217 IFGDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPGVYTNIS 275
Query: 426 RLRDWILEATTKASMPLAPTMAPAPAAPSTAWP 458
+WI + ++ M + P +WP
Sbjct: 276 HHFEWIQKLMAQSGM----------SQPDPSWP 298
Score = 169 bits (427), Expect = 2e-41
Identities = 98/245 (40%), Positives = 132/245 (53%), Gaps = 19/245 (7%)
Query: 825 TRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD---PKQWAA 881
+RIVGG A G WPWQ SL L H CG L++ RW L+AAHCF+ Y D P W
Sbjct: 40 SRIVGGEDAELGRWPWQGSLRLWD-SHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMV 98
Query: 882 FLGT----PFLSGAEGQLER--VARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPIC 935
G P + R V+ IY P Y L YD+AL++L+ PV ++ ++PIC
Sbjct: 99 QFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQPIC 157
Query: 936 LPEPAPRPPDGTRCVITGWGSVREGGSMA--RQLQKAAVRLLSEQTCRRFY-----PVQI 988
L + T C +TGWG ++E ++ LQ+ V +++ C + I
Sbjct: 158 LQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDI 217
Query: 989 SSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAA 1048
M+CAG QGG D+C GD+GGPLAC + +G W GV SWG GCGRP+ PGVYT ++
Sbjct: 218 FGDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPGVYTNISH 276
Query: 1049 VRGWI 1053
WI
Sbjct: 277 HFEWI 281
Score = 164 bits (414), Expect = 5e-40
Identities = 95/269 (35%), Positives = 142/269 (52%), Gaps = 19/269 (7%)
Query: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTK- 550
CG R +R+VGG A G PWQ SL+ H CG +++ RW L+AAHCF
Sbjct: 33 CGRRVIT---SRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSD 89
Query: 551 -------VEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLA 603
+ Q S L + + + L P Y G +D+A+++L++P+
Sbjct: 90 LSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVT 148
Query: 604 FNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNA-TKPELLQKASVGIIDQKTCSVL- 661
+ K+IQP+CL + +F C ++GWG +E A P LQ+ V II+ C+ L
Sbjct: 149 YTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLF 208
Query: 662 --YNF--SLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKK 717
Y+F + M+CAG +G D+C GDSGGPLAC + G++Y G+VSWG+GC + +
Sbjct: 209 LKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNR 267
Query: 718 PGVYTRITRLKGWILEIMSSQPLPMSPPS 746
PGVYT I+ WI ++M+ + PS
Sbjct: 268 PGVYTNISHHFEWIQKLMAQSGMSQPDPS 296
>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
Length = 416
Score = 182 bits (461), Expect = 2e-45
Identities = 97/246 (39%), Positives = 149/246 (60%), Gaps = 12/246 (4%)
Query: 492 CGARPAMEKPT--RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549
CG + A T ++V G + G PWQ S++ RH+CGA+++ RWLLSAAHCF
Sbjct: 171 CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCF--- 227
Query: 550 KVEQVRAHLGTASLLGLGGSPVKIG-LRRVVLHPLYN-PGILDFDLAVLELASPLAFNKY 607
++ + T + + P ++ ++ H Y+ PG+ D D+A+++LA ++F +Y
Sbjct: 228 -AKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHD-DIALVQLAEEVSFTEY 285
Query: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFS-- 665
I+ +CLP A K +++GWG T N + P +LQ+ + IID K C+ Y +S
Sbjct: 286 IRKICLPEAKMKLSENDNVVVTGWG-TLYMNGSFPVILQEDFLKIIDNKICNASYAYSGF 344
Query: 666 LTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRIT 725
+TD M+CAGF+ G+ D+CQ DSGGPLA ++ +++L GIVSWG GC + KPGVYTR+T
Sbjct: 345 VTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVT 404
Query: 726 RLKGWI 731
+ WI
Sbjct: 405 SYRNWI 410
Score = 176 bits (447), Expect = 8e-44
Identities = 90/251 (35%), Positives = 142/251 (56%), Gaps = 13/251 (5%)
Query: 191 CGLQPAWRM--AGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEF 248
CG Q A + +IV G + G +PWQAS++ H+CGA++I++RWL+SAAHCF +
Sbjct: 171 CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKK 230
Query: 249 QDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHI 308
+ W G + +V I+ H Y++ D+A+++L + F +I
Sbjct: 231 NNSKDWTVNFGIVV----NKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYI 286
Query: 309 QPVCLPAATHIFPPSKKCLISGWG--YLKEDFLVKPEVLQKATVELLDQALCASLYGHS- 365
+ +CLP A + +++GWG Y+ F P +LQ+ ++++D +C + Y +S
Sbjct: 287 RKICLPEAKMKLSENDNVVVTGWGTLYMNGSF---PVILQEDFLKIIDNKICNASYAYSG 343
Query: 366 -LTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARV 424
+TD M+CAG++ G+ D+CQ DSGGPL + + L GIVSWG GC + +PGVY RV
Sbjct: 344 FVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRV 403
Query: 425 TRLRDWILEAT 435
T R+WI T
Sbjct: 404 TSYRNWITSKT 414
Score = 174 bits (442), Expect = 3e-43
Identities = 91/234 (38%), Positives = 129/234 (55%), Gaps = 13/234 (5%)
Query: 826 RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885
+IV G ++ G WPWQ S+ + R H CGA L++ RWLLSAAHCF + K W G
Sbjct: 184 KIVNGKSSLEGAWPWQASMQWKGR-HYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGI 242
Query: 886 ----PFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAP 941
P+++ +V I H Y+ L D+AL++LA V + +R ICLPE
Sbjct: 243 VVNKPYMT------RKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKM 296
Query: 942 RPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQ--ISSRMLCAGFPQ 999
+ + V+TGWG++ GS LQ+ ++++ + C Y ++ MLCAGF
Sbjct: 297 KLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMS 356
Query: 1000 GGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
G D+C D+GGPLA + W L G+ SWG GCG+ + PGVYTRV + R WI
Sbjct: 357 GEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410
>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
Length = 247
Score = 178 bits (452), Expect = 2e-44
Identities = 89/229 (38%), Positives = 128/229 (55%), Gaps = 12/229 (5%)
Query: 503 RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTAS 562
++VGG+ VP+QVSL G HFCG +++ ++W++SA HC+ +++ LG +
Sbjct: 23 KIVGGYNCEENSVPYQVSLNSGY-HFCGGSLINEQWVVSAGHCYK----SRIQVRLGEHN 77
Query: 563 LLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPV 622
+ L G+ I +++ HP Y+ L+ D+ +++L+S N + + LP A
Sbjct: 78 IEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPA--T 135
Query: 623 GRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDS 682
G KC+ISGWGNT A P+ LQ ++ Q C Y +T M C GFLEG DS
Sbjct: 136 GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDS 195
Query: 683 CQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWI 731
CQGDSGGP+ C L G+VSWG GCAQ KPGVYT++ WI
Sbjct: 196 CQGDSGGPVVCNG-----QLQGVVSWGDGCAQKNKPGVYTKVYNYVKWI 239
Score = 156 bits (395), Expect = 9e-38
Identities = 85/232 (36%), Positives = 121/232 (52%), Gaps = 17/232 (7%)
Query: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGAT 261
+IVGG P+Q SL HFCG ++IN +W+VSA HC+ ++ +G
Sbjct: 23 KIVGGYNCEENSVPYQVSLNSGY-HFCGGSLINEQWVVSAGHCYK-----SRIQVRLGEH 76
Query: 262 YLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFP 321
+ E + +I++HP Y+ T + D+ +++L+S + + LP A P
Sbjct: 77 NIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTA----P 132
Query: 322 PSK--KCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGK 379
P+ KCLISGWG P+ LQ +L QA C + Y +T M C G+L+G
Sbjct: 133 PATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGG 192
Query: 380 VDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431
DSCQGDSGGP+VC L G+VSWG GCA+ +PGVY +V WI
Sbjct: 193 KDSCQGDSGGPVVCNGQ-----LQGVVSWGDGCAQKNKPGVYTKVYNYVKWI 239
Score = 144 bits (364), Expect = 3e-34
Identities = 89/231 (38%), Positives = 123/231 (53%), Gaps = 17/231 (7%)
Query: 826 RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885
+IVGG P+QVSL H CG L+ E+W++SA HC+ + LG
Sbjct: 23 KIVGGYNCEENSVPYQVSL--NSGYHFCGGSLINEQWVVSAGHCYK-----SRIQVRLGE 75
Query: 886 PFLSGAEG--QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRP 943
+ EG Q A+I +HP Y+ TL+ D+ L++L+ + V I LP AP P
Sbjct: 76 HNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPT-AP-P 133
Query: 944 PDGTRCVITGWGSVREGGS-MARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGV 1002
GT+C+I+GWG+ G+ +LQ +LS+ C YP +I+S M C GF +GG
Sbjct: 134 ATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGK 193
Query: 1003 DSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
DSC GD+GGP+ C L GV SWG GC + + PGVYT+V WI
Sbjct: 194 DSCQGDSGGPVVCNGQ-----LQGVVSWGDGCAQKNKPGVYTKVYNYVKWI 239
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,200,259
Number of Sequences: 37866
Number of extensions: 2365497
Number of successful extensions: 14625
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 9378
Number of HSP's gapped (non-prelim): 3548
length of query: 1059
length of database: 18,247,518
effective HSP length: 113
effective length of query: 946
effective length of database: 13,968,660
effective search space: 13214352360
effective search space used: 13214352360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.