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Search of human proteins with 33620769
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo
sapiens]
(1792 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 3611 0.0
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 3528 0.0
gi|28077093 retinoblastoma-binding protein 6 isoform 3 [Homo sap... 205 4e-52
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 124 1e-27
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 117 1e-25
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 117 1e-25
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 110 2e-23
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 109 2e-23
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 109 2e-23
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 105 5e-22
gi|87299628 biorientation of chromosomes in cell division 1-like... 104 7e-22
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 103 1e-21
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] 102 3e-21
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 100 2e-20
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 100 2e-20
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 98 6e-20
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 98 8e-20
gi|167234419 thyroid hormone receptor associated protein 3 [Homo... 97 1e-19
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 97 1e-19
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 97 1e-19
gi|150170670 piccolo isoform 2 [Homo sapiens] 94 9e-19
gi|150378539 piccolo isoform 1 [Homo sapiens] 94 9e-19
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 91 8e-18
gi|148746195 trichohyalin [Homo sapiens] 85 7e-16
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 84 9e-16
gi|169218320 PREDICTED: similar to BCL2-associated transcription... 83 2e-15
gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens] 82 4e-15
gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 82 5e-15
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 82 5e-15
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 82 5e-15
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 3611 bits (9364), Expect = 0.0
Identities = 1792/1792 (100%), Positives = 1792/1792 (100%)
Query: 1 MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD 60
MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD
Sbjct: 1 MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD 60
Query: 61 NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANL 120
NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANL
Sbjct: 61 NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANL 120
Query: 121 AEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDK 180
AEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDK
Sbjct: 121 AEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDK 180
Query: 181 NFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLP 240
NFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLP
Sbjct: 181 NFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLP 240
Query: 241 EEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCH 300
EEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCH
Sbjct: 241 EEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCH 300
Query: 301 QNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRS 360
QNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRS
Sbjct: 301 QNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRS 360
Query: 361 PISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISV 420
PISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISV
Sbjct: 361 PISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISV 420
Query: 421 HSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLL 480
HSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLL
Sbjct: 421 HSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLL 480
Query: 481 HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE 540
HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE
Sbjct: 481 HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE 540
Query: 541 RSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP 600
RSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP
Sbjct: 541 RSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP 600
Query: 601 PPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDE 660
PPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDE
Sbjct: 601 PPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDE 660
Query: 661 FTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS 720
FTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS
Sbjct: 661 FTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS 720
Query: 721 RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS 780
RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS
Sbjct: 721 RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS 780
Query: 781 PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK 840
PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK
Sbjct: 781 PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK 840
Query: 841 YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPE 900
YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPE
Sbjct: 841 YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPE 900
Query: 901 KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS
Sbjct: 901 KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
Query: 961 REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK 1020
REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK
Sbjct: 961 REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK 1020
Query: 1021 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK 1080
RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK
Sbjct: 1021 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK 1080
Query: 1081 DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL 1140
DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL
Sbjct: 1081 DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL 1140
Query: 1141 DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI 1200
DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI
Sbjct: 1141 DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI 1200
Query: 1201 SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1260
SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG
Sbjct: 1201 SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1260
Query: 1261 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK 1320
SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK
Sbjct: 1261 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK 1320
Query: 1321 WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDV 1380
WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDV
Sbjct: 1321 WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDV 1380
Query: 1381 SHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF 1440
SHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF
Sbjct: 1381 SHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF 1440
Query: 1441 KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS 1500
KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS
Sbjct: 1441 KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS 1500
Query: 1501 PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1560
PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS
Sbjct: 1501 PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1560
Query: 1561 VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSH 1620
VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSH
Sbjct: 1561 VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSH 1620
Query: 1621 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1680
SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA
Sbjct: 1621 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1680
Query: 1681 AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK 1740
AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK
Sbjct: 1681 AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK 1740
Query: 1741 HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV 1792
HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV
Sbjct: 1741 HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV 1792
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 3528 bits (9148), Expect = 0.0
Identities = 1758/1792 (98%), Positives = 1758/1792 (98%), Gaps = 34/1792 (1%)
Query: 1 MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD 60
MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD
Sbjct: 1 MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD 60
Query: 61 NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANL 120
NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANL
Sbjct: 61 NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANL 120
Query: 121 AEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDK 180
AEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDK
Sbjct: 121 AEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDK 180
Query: 181 NFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLP 240
NFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLP
Sbjct: 181 NFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLP 240
Query: 241 EEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCH 300
EEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCH
Sbjct: 241 EEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCH 300
Query: 301 QNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRS 360
QNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRS
Sbjct: 301 QNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRS 360
Query: 361 PISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISV 420
PISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISV
Sbjct: 361 PISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISV 420
Query: 421 HSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLL 480
HSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLL
Sbjct: 421 HSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLL 480
Query: 481 HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE 540
HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE
Sbjct: 481 HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE 540
Query: 541 RSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP 600
RSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP
Sbjct: 541 RSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP 600
Query: 601 PPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDE 660
PPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEE
Sbjct: 601 PPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEE--------- 651
Query: 661 FTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS 720
SKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS
Sbjct: 652 -------------------------SKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS 686
Query: 721 RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS 780
RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS
Sbjct: 687 RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS 746
Query: 781 PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK 840
PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK
Sbjct: 747 PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK 806
Query: 841 YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPE 900
YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPE
Sbjct: 807 YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPE 866
Query: 901 KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS
Sbjct: 867 KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 926
Query: 961 REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK 1020
REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK
Sbjct: 927 REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK 986
Query: 1021 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK 1080
RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK
Sbjct: 987 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK 1046
Query: 1081 DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL 1140
DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL
Sbjct: 1047 DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL 1106
Query: 1141 DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI 1200
DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI
Sbjct: 1107 DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI 1166
Query: 1201 SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1260
SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG
Sbjct: 1167 SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1226
Query: 1261 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK 1320
SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK
Sbjct: 1227 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK 1286
Query: 1321 WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDV 1380
WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDV
Sbjct: 1287 WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDV 1346
Query: 1381 SHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF 1440
SHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF
Sbjct: 1347 SHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF 1406
Query: 1441 KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS 1500
KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS
Sbjct: 1407 KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS 1466
Query: 1501 PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1560
PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS
Sbjct: 1467 PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1526
Query: 1561 VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSH 1620
VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSH
Sbjct: 1527 VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSH 1586
Query: 1621 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1680
SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA
Sbjct: 1587 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1646
Query: 1681 AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK 1740
AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK
Sbjct: 1647 AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK 1706
Query: 1741 HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV 1792
HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV
Sbjct: 1707 HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV 1758
>gi|28077093 retinoblastoma-binding protein 6 isoform 3 [Homo
sapiens]
Length = 118
Score = 205 bits (521), Expect = 4e-52
Identities = 102/108 (94%), Positives = 105/108 (97%)
Query: 1 MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD 60
MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD
Sbjct: 1 MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD 60
Query: 61 NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSAS 108
NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKA+ ++ S
Sbjct: 61 NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAVCKNTIS 108
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 124 bits (310), Expect = 1e-27
Identities = 326/1473 (22%), Positives = 510/1473 (34%), Gaps = 216/1473 (14%)
Query: 481 HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE 540
H + P + R G P E S P+ + S Y ++ +
Sbjct: 287 HTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKS 346
Query: 541 RSQRTQGPSLPATPVFVPVPPPPLY------PPPPHTLPLP--PGVPPPQFSP---QFPP 589
++ + P +T P P P L P P T PL P PP + SP + PP
Sbjct: 347 ATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPP 406
Query: 590 GQPPPAGYSVPPPGFPPAPANLSTP-WVSSGVQTAHSNTIPTTQ----APPLSREEFYRE 644
P S PP+P SS ++ P + + P S+ +
Sbjct: 407 KSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGR 466
Query: 645 QRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSK 704
+R K S+ + A + + +R SRS+SP S RS+ + +
Sbjct: 467 AKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRS--RSAQRWGR 524
Query: 705 SRSGSTRSRSYS----------------RSFSRSHSRSYSRSPPYPRRGRGKS--RNYRS 746
SRS R RS S RS S RS+SRSP R R ++ R RS
Sbjct: 525 SRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRS 584
Query: 747 RSRSHGYHRSRSRSP---------PYRRYHSRSRSP--QAFRGQSPNKRNVPQGETEREY 795
RSR+ RSRSR+P P RR SRSR+P + R +SP +R R
Sbjct: 585 RSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRS 644
Query: 796 FNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSA 855
P A GRS R P + R R R + + A + R
Sbjct: 645 GRSRSRTP------ARRGRSRS-RTPARRGRSRSRTPARRSGRSR-SRTPARRGRSRSRT 696
Query: 856 NRENFSPERFLPLNIRN---SPFTRGR------REDYVGGQSHRSRNIGSNYPEK--LSA 904
R S R L R+ +P RGR R++ RSR+ S +K +S+
Sbjct: 697 PRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISS 756
Query: 905 RDGH---NQKDNTKSKEKESENAPGDGKGNKHKKH---RKRRKGEESEGFLNPELLETSR 958
R + + KS+ + G K K R+ R G + SR
Sbjct: 757 RRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSR 816
Query: 959 KSREPTGVEENKT------DSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDK---RER 1009
S P +++KT S P TP R + + +SV+ + +
Sbjct: 817 SSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESS 876
Query: 1010 DKPKAKGDKTKRKN-DGSAVSKKENIVKP------AKGPQEKVDG-----ERERSPRSEP 1057
P+ K R + GS+ + ++ P + PQ KV +R S S P
Sbjct: 877 PDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSP 936
Query: 1058 -PIKKAKEETPKTDNTKS---------------SSSSQKDEKI--TGTPRKAHSKSAKEH 1099
P + TP+ + S S SS D K+ PR++HS S +
Sbjct: 937 SPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPY 996
Query: 1100 QETK--------------PVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKN----KPLD 1141
+ K P +EK K + K+ P ++ L
Sbjct: 997 PKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQ 1056
Query: 1142 NKGEKR-----KRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTP- 1195
KG+ + + T V + S SK + + K R P TE R+P
Sbjct: 1057 LKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSP--KGGRSRSSSPVTELASRSPI 1114
Query: 1196 EKDKISLSA-PAKKIKLNRETGKKIGSTENI----SNTKEPSEKLESTSSKVKQEKVKGK 1250
+D+ SA P K ++ E + + + SN+ +LE+ SK
Sbjct: 1115 RQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESK--------- 1165
Query: 1251 VRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDV 1310
K+ +T PV+ E + + ++T + + E
Sbjct: 1166 --EKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETK 1223
Query: 1311 IIMIQVPQSKWDKDDFESEEEDVKSTQPISSV-GKPASVIKNVSTKPSNIVKYPEKESEP 1369
+P S D++ E E KS +P + +S +K +ST SN PE E P
Sbjct: 1224 EQNSALPTSSQDEELMEVVE---KSEEPAGQILSHLSSELKEMST--SNFESSPEVEERP 1278
Query: 1370 SEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLE----KEN----PEKRKN 1421
+ + T D S E + ASS G ++ L +EN P + +N
Sbjct: 1279 AVSL---TLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRN 1335
Query: 1422 STQPEKESNL---DRLNEQGNFKSLSQSSKEARTSDKHDSTRAS--SNKDFTPNRDKKTD 1476
S E N + E N L+Q + K STR+S S+ + +P+ +K
Sbjct: 1336 SGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAG 1395
Query: 1477 YDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSP 1536
+ + SS D +PSR + S++ + P + LP+ + S+ +S
Sbjct: 1396 MSSNQSISSPVLDAVPR------TPSRERSSSA---SSPEMKDGLPRTPSRRSRSGSSPG 1446
Query: 1537 SRDRK--PHDHKATYDT-------KRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKL 1587
RD P H + + + P+ D +P R+ SS
Sbjct: 1447 LRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELN 1506
Query: 1588 LYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSE 1647
L P Q E+ +D+ TV P L SR S + +A + +ESDS
Sbjct: 1507 NKCLTP---QRERSGSESSVDQKTVARTP-LGQRSRSGSSQELDVKPSASPQERSESDSS 1562
Query: 1648 SNVSVK-------EEESSGNISKDLKDKIVEKAKESLDTAAVVQV--GISRNQSHS---- 1694
+ K S + D K ++ + S + V R QS S
Sbjct: 1563 PDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSP 1622
Query: 1695 -----SPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1749
+P P RS S S S+ R S SS+ + K + ++ + K K
Sbjct: 1623 EPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKS 1682
Query: 1750 HAGTEVELEKSQKHKHKKKK-SKKNKDKEKEKE 1781
+S +K + S++++ E
Sbjct: 1683 RTPPRRRSSRSSPELTRKARLSRRSRSASSSPE 1715
Score = 85.1 bits (209), Expect = 6e-16
Identities = 211/1106 (19%), Positives = 397/1106 (35%), Gaps = 178/1106 (16%)
Query: 668 ELMEYKKIQKER-RRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRS 726
+L E + + ER R +F S S GSS+ ++R + + +S S
Sbjct: 123 QLAELNEKKNERLRAAFGISDSYVDGSSFD----PQRRAREAKQPAPEPPKPYSLVRESS 178
Query: 727 YSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNV 786
SRSP ++ + K ++ RS S R R +S +++ S S S + + +SP ++
Sbjct: 179 SSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKR-KHRSPTPKSK 237
Query: 787 PQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYA 846
+ + ++ +R P P +A+ S D + R R R K +
Sbjct: 238 RKSKDKKRKRSR-STTPAPKSRRAHRSTSADSASSSDTSRSRS-----RSAAAKTHTTAL 291
Query: 847 AGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARD 906
AG P P++ R ++PF+ G + R + PE + +
Sbjct: 292 AGRSPSPASGRRGEG----------DAPFSE-------PGTTSTQR---PSSPETATKQP 331
Query: 907 GHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRK----GEESEGFLNPELLETSRKSRE 962
+D K K+++S P E G +P+ L T+ S+E
Sbjct: 332 SSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGG--SPQPLATTPLSQE 389
Query: 963 PTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRK 1022
P PS T R P E + S SE P + K R
Sbjct: 390 PVNP-----------PSEASPTRDRSPPKSPEKLPQSSSSES-----SPPSPQPTKVSRH 433
Query: 1023 NDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIK--KAKEETP--KTDNTKSSSSS 1078
S S K PA G ++ RS K K+ TP + ++S +++
Sbjct: 434 ASSSPESPKP---APAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATA 490
Query: 1079 QKDEKITGTP-RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNE-- 1135
++ + TP ++ HS+S S + + + +++ P
Sbjct: 491 KRGRSRSRTPTKRGHSRSR------------------SPQWRRSRSAQRWGRSRSPQRRG 532
Query: 1136 KNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDT--EKMDR 1193
+++ G R R T+ +G S S + + R P R
Sbjct: 533 RSRSPQRPGWSRSRNTQRRG-----RSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSR 587
Query: 1194 TPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQE-------K 1246
TP + + P ++ +R ++ S ++ P+ + T S V++ +
Sbjct: 588 TPARRRSRSRTPTRRRSRSRTPARR-----GRSRSRTPARRRSRTRSPVRRRSRSRSPAR 642
Query: 1247 VKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVR---KSEEKTDTK--RTVIKTMEEYNN 1301
G+ R + G S + S +P R +S +T + R+ +T +
Sbjct: 643 RSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRS 702
Query: 1302 DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPIS-SVGKPASVIKNVSTKPSNIV 1360
+ + + PQ + + +++Q S S P +S++ S +
Sbjct: 703 RSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSL 762
Query: 1361 KYPEKESEPSEKIQKFTKDVS---HEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPE 1417
P +++ +++ S + Q + S++ +S K K++ +P
Sbjct: 763 SSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPP 822
Query: 1418 KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNK----DFTPNRDK 1473
++ S P ++S+ + KS + + + TS + + + + + +P+ +
Sbjct: 823 PKQKSKTPSRQSH-SSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPEL 881
Query: 1474 KTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSN 1533
K+ +R S T + SPSR+ +P+ + + + S S+
Sbjct: 882 KSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSP------QPKVKAIISPRQRSHSGSSS 935
Query: 1534 SSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNP 1593
SPSR ++ ++SV +PC + E +L ++ SS
Sbjct: 936 PSPSR----------VTSRTTPRRSRSV--SPCSNVESRLLPRYSHSGSSS--------- 974
Query: 1594 PETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
P+T+V+ E Q ++ P P++ +A P + S S+S
Sbjct: 975 PDTKVKPETPPRQSHSGSISPYPKV---------------KAQTPPGPSLSGSKS--PCP 1017
Query: 1654 EEESSGNISKDLKDKIVEKAKESLDTAAVVQ---------VGISRNQSHSSPSVSPS-RS 1703
+E+S KD +V+ SL A V+ G+S Q SP RS
Sbjct: 1018 QEKS--------KDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRS 1069
Query: 1704 HSPSGSQTRSHSSSAS-SAESQDSKK 1728
+ S +SHS S S ++SQ S K
Sbjct: 1070 DTSSPEVRQSHSESPSLQSKSQTSPK 1095
Score = 74.7 bits (182), Expect = 7e-13
Identities = 218/1164 (18%), Positives = 406/1164 (34%), Gaps = 149/1164 (12%)
Query: 643 REQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTY 702
RE+++ +++K +S+ + + K+ K+++R SRS +P S + S T
Sbjct: 207 RERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRS-TS 265
Query: 703 SKSRSGSTRSRSYSRS-FSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSP 761
+ S S S SRS SRS +++H+ + + P P GR R G S
Sbjct: 266 ADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGR----------RGEG---DAPFSE 312
Query: 762 PYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDP 821
P R SP+ Q + P + +++ + P P ++ G P
Sbjct: 313 PGTTSTQRPSSPETATKQPSS----PYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTP 368
Query: 822 FEKERYREWERKYREWYEKYYKGYAAGAQPRPSA----NRENFSP--------ERFLPLN 869
ER+ G P+P A ++E +P +R P +
Sbjct: 369 LLAERH--------------------GGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKS 408
Query: 870 IRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGK 929
P + Q + S+ PE S + G K
Sbjct: 409 PEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAK 468
Query: 930 GNKHKKHRKRRKGEESEGFLNPELLETSR-KSREPTGVEENKTDSLFVLPSRDDATPVRD 988
+K H R+ S +P + R +SR PT +++ S SR R
Sbjct: 469 RDKSHSHTPSRRMGRSR---SPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRS 525
Query: 989 EPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGE 1048
+ R R+ + ++ R+ + S ++ P
Sbjct: 526 RSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTP-----AR 580
Query: 1049 RERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP--RKAHSKSAKEHQETKPVK 1106
R RS P ++++ TP ++S + +++ + TP R++ ++S +
Sbjct: 581 RGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSP 640
Query: 1107 EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNK-PLDNKGEKRKRKTEEKG-----VDKDF 1160
+ + S+ + A++ +++ P G R R +G +
Sbjct: 641 ARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRG 700
Query: 1161 ESSSMKISKLEVTEIVKPSPKRKMEPDTEKMD--RTPEKDKISLSAP-AKKIKLNRETGK 1217
S S + + + P + + +E+ + RT ++ S S+P KK +++ +
Sbjct: 701 RSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSR 760
Query: 1218 KIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGS 1277
+ S + + ++ + S SS ++K + RR +G+ + S + S
Sbjct: 761 SLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSS 820
Query: 1278 PVRKSEEKTDTKRTVIKTMEEYN-NDNTAPAEDVIIMIQVPQ---SKWDKDDFESE-EED 1332
P K + KT ++++ + T P + I Q + + + FES + +
Sbjct: 821 PPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPE 880
Query: 1333 VKSTQPI--SSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVK 1390
+KS P S G +K+ ST P + P + S P K++ +S H
Sbjct: 881 LKSRTPSRHSCSGSSPPRVKS-STPPR---QSPSRSSSPQPKVKAI---ISPRQRSHSGS 933
Query: 1391 SSKNSASSEKGKTKDRDYSVLEKENPEKR-------KNSTQPE---KESNLDRLNEQGNF 1440
SS + + T R SV N E R S+ P+ K R + G+
Sbjct: 934 SSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSI 993
Query: 1441 K-------------SLSQSSKEARTSDKHDS---------TRASSNKDFTP--------- 1469
SLS S DS + + K TP
Sbjct: 994 SPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVS 1053
Query: 1470 -------------NRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPR 1516
+R + + R+ S + T K SR+ + ++
Sbjct: 1054 SLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSP 1113
Query: 1517 EERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEA 1576
+D + KS SP + R D ++Y T N + +EK L
Sbjct: 1114 IRQDRGEFSASPMLKSGMSPEQSRFQSD-SSSYPTVDSNSLLGQSRLETAESKEKMALPP 1172
Query: 1577 RNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAA 1636
+ + +S + +P Q E + + K T++ P+ S SS T+E + A
Sbjct: 1173 QEDATASPPRQKDKFSPFPVQDRPE--SSLVFKDTLRTPPR-ERSGAGSSPETKEQNSAL 1229
Query: 1637 FEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQ----VGISRNQS 1692
P ++ + V K EE +G I L ++ E + + +++ V+ V ++ +QS
Sbjct: 1230 --PTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQS 1287
Query: 1693 HSSPSVSPSRSHSPSGSQTRSHSS 1716
S S+ S + S H S
Sbjct: 1288 QSQASLEAVEVPSMASSWGGPHFS 1311
Score = 72.0 bits (175), Expect = 5e-12
Identities = 171/842 (20%), Positives = 308/842 (36%), Gaps = 93/842 (11%)
Query: 950 NPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFK-SVSEKDKRE 1008
NP++L+ RK R E L + ++ + + TF+ + EKD
Sbjct: 54 NPDILDHERKRRVELRCLE--------LEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNP 105
Query: 1009 RDKPKAKGDK---TKRKNDGSAVSKKENIVKPAKGPQEK-VDGERERSPRSEPPIKKAKE 1064
K + G + T+ KK ++ A G + VDG R K+
Sbjct: 106 GGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAP 165
Query: 1065 ETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEH---QETKPVKEEKVKKDYSKDVKSE 1121
E PK + SSS + TP++ K K+ E+ + E+ K K +SE
Sbjct: 166 EPPKPYSLVRESSSSRSP----TPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSE 221
Query: 1122 KLTTKEE-KAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSP 1180
+ K + ++ P K K D K ++ + T + S+S + T +
Sbjct: 222 SESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRS 281
Query: 1181 KRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSS 1240
T R+P +PA R G S ++T+ PS +T
Sbjct: 282 AAAKTHTTALAGRSP--------SPASG---RRGEGDAPFSEPGTTSTQRPSSPETATKQ 330
Query: 1241 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN 1300
+ K K +++ + T S S + +ST +P E+ + T
Sbjct: 331 PSSPYEDKDKDKKEKSATRPSPSP--ERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQ 388
Query: 1301 NDNTAPAEDVIIMIQVPQSKWDK-DDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNI 1359
P+E + P +K S E S QP + V + AS S KP+
Sbjct: 389 EPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQP-TKVSRHASSSPE-SPKPAPA 446
Query: 1360 V-KYPEKESEPSEKIQ---KFTKDVSH-EIIQHEVKSSKNSASSEKGKTKDRDYSVL--- 1411
+ E S P+ K + + +D SH + S++ A++++G+++ R +
Sbjct: 447 PGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHS 506
Query: 1412 -----------------EKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSD 1454
+P++R S P++ N Q + S+S++ R+
Sbjct: 507 RSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQR--RGRSRSARRGRSHS 564
Query: 1455 KHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD---SPSRNKDSAS-- 1509
+ +TR S + TP R + +R + ++RR TRR+ +P+R S S
Sbjct: 565 RSPATRGRS-RSRTPARRGR----SRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRT 619
Query: 1510 GQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCK-- 1567
+ + R + ++ S S SR R P + ++ P +S + P +
Sbjct: 620 PARRRSRTRSPVRRRSRSRSPARRSGRSRSRTP-ARRGRSRSRTPARRGRSRSRTPARRS 678
Query: 1568 DREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSD 1627
R + AR + S P + + + +S + PQ S SS+
Sbjct: 679 GRSRSRTPARRGRSRS--------RTPRRGRSRSRSLVRRGRSHSR-TPQRRGRSGSSSE 729
Query: 1628 LTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKD-KIVEKAKESLDTAAVVQVG 1686
++ S S S+ +K+ S S+ L + K++ SL +
Sbjct: 730 RKNKS-----RTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSP 784
Query: 1687 ISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKK 1746
+ +S + P S S S P +++R+ + S+ S K+K K ++ H H K
Sbjct: 785 CPKQKSQTPPRRSRSGSSQPK-AKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK 843
Query: 1747 HK 1748
K
Sbjct: 844 VK 845
Score = 59.7 bits (143), Expect = 2e-08
Identities = 242/1281 (18%), Positives = 417/1281 (32%), Gaps = 175/1281 (13%)
Query: 560 PPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSG 619
PP PP P P P+ P Q +G S P P + +TP S
Sbjct: 896 PPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPS---RVTSRTTPRRSRS 952
Query: 620 VQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKER 679
V + + + P S ++K E + + + K K Q
Sbjct: 953 VSPC--SNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKV-----KAQTPP 1005
Query: 680 RRSFSRSKSPYS----------------------------GSSYSRSSYTYSKSRSGST- 710
S S SKSP G SY S K +S ++
Sbjct: 1006 GPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSP 1065
Query: 711 --RSRSYSRSFSRSHSRS---YSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRR 765
RS + S +SHS S S+S P+ GR +S S SRSP +
Sbjct: 1066 DHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRS--------SSPVTELASRSPIRQD 1117
Query: 766 YHSRSRSPQAFRGQSPNKRN----------------VPQGETEREYFNRYREVPPPYDMK 809
S SP G SP + + Q E +PP D
Sbjct: 1118 RGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDAT 1177
Query: 810 AYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLN 869
A R D PF + E +++ + +GA P +N + LP +
Sbjct: 1178 ASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRE-RSGAGSSPETKEQNSA----LPTS 1232
Query: 870 IRNSPFTRG-RREDYVGGQ--SHRSRNIG----SNYPEKLSARDGH------NQKDNTKS 916
++ + + GQ SH S + SN+ + +Q + S
Sbjct: 1233 SQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQAS 1292
Query: 917 KEKESENAPGDGKGNKH--KKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 974
E + G H +H++ E L ++ P G E N S
Sbjct: 1293 LEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPL---EFRNSGPLGTEMNTGFSS 1349
Query: 975 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENI 1034
V ++D + P + T S+ K++ R + + + + + +S ++I
Sbjct: 1350 EV---KEDL----NGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSI 1402
Query: 1035 VKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSK 1094
P + S S P +K TP + SS +D +GTP +
Sbjct: 1403 SSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDG--SGTPSRHSLS 1460
Query: 1095 SAKEHQETKPVKEEKVKKDYSKDVKSEKLT-TKEEKAKKPNEKNKPLDNK--GEKRKRKT 1151
+ + P + + + + + L T +++ P+ L+NK +R+R
Sbjct: 1461 GSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPE--LNNKCLTPQRERSG 1518
Query: 1152 EEKGVDKDF--------ESSSMKISKLEVTEIVKPSPKRKME--PDTEKMDRTPEKDKI- 1200
E VD+ S S +L+V P + + + PD++ RTP + +
Sbjct: 1519 SESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSR 1578
Query: 1201 SLSAPA--KKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGT 1258
S S+P K +L+ + GS+ + + + + +S S + K
Sbjct: 1579 SGSSPEVDSKSRLSPRRSRS-GSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSR 1637
Query: 1259 EGSSSTLVDYTSTSSTGGSPVRKSEE---KTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQ 1315
GSSS S G S S E K+ T R ++ E + P
Sbjct: 1638 SGSSSK---GRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTP--------- 1685
Query: 1316 VPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKES-EPSEKIQ 1374
P+ + + E + S + S+ P + S P + P S EP+EK +
Sbjct: 1686 -PRRRSSRSSPELTRKARLSRRSRSASSSP----ETRSRTPPRHRRSPSVSSPEPAEKSR 1740
Query: 1375 KFTKDVSHEIIQHEVKSSKNSASSEK--GKTKDRDYSVLEKENPEKRKN--------STQ 1424
+ S + + S + + S K G + R S EK +R++ S +
Sbjct: 1741 SSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR 1800
Query: 1425 PEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSS 1484
++ + R+ + S S AR S+R + TP +K +
Sbjct: 1801 RQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAP 1860
Query: 1485 SKR-RDEKNELTRRKD----------------SPSRNKDSASGQKNKPREERDLPKKGTG 1527
KR R + T R+ SP + S S R R +
Sbjct: 1861 WKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSR 1920
Query: 1528 DSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKL 1587
+S + P R+ T +R T V + + R V R+ +S
Sbjct: 1921 RRSRSRTPPVTRRRSRSRTPT-TRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSP--- 1976
Query: 1588 LYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSE 1647
+ ++ +T + +S P + SR +S +TR + P
Sbjct: 1977 ---ITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSR-TSPVTRRRSRSRTPPAIRRRSRS 2032
Query: 1648 SNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPS 1707
+ + S ++ + + + + + S+ S RS S +
Sbjct: 2033 RTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSAT 2092
Query: 1708 GSQTRSHSSSASSAESQDSKK 1728
TR+HS S + + +S +
Sbjct: 2093 PPATRNHSGSRTPPVALNSSR 2113
Score = 55.5 bits (132), Expect = 5e-07
Identities = 68/253 (26%), Positives = 100/253 (39%), Gaps = 13/253 (5%)
Query: 576 PGVPPPQFS-PQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAP 634
PGVP P G P+ + P ++ S+ SS ++ S++ ++
Sbjct: 2499 PGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGS 2558
Query: 635 PLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSS 694
S E + + K+ + +E + +R+R S S S S SS
Sbjct: 2559 SSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSS 2618
Query: 695 YSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSR----------SPPYPRRGRGKSRNY 744
S SS + S S S S+ S S S S S S S S ++ SP P G +SR+
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSP 2678
Query: 745 RSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNK--RNVPQGETEREYFNRYREV 802
R S RS S SP RR S SP+ + S + R +G++ R RE
Sbjct: 2679 RKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRET 2738
Query: 803 PPPYDMKAYYGRS 815
P P M+ RS
Sbjct: 2739 PSPRPMRHRSSRS 2751
Score = 45.8 bits (107), Expect = 4e-04
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 3/155 (1%)
Query: 1638 EPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRN-QSHSSP 1696
E D N E + + + +L +K E+ + + + G S + Q +
Sbjct: 100 EKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRARE 159
Query: 1697 SVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVE 1756
+ P+ S R SSS S Q KKKKKKK++ + + ++ +K + + +
Sbjct: 160 AKQPAPEPPKPYSLVRESSSSRSPTPKQ--KKKKKKKDRGRRSESSSPRRERKKSSKKKK 217
Query: 1757 LEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVT 1791
+ K +K +S K K K K+K ++ +S T
Sbjct: 218 HRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTT 252
Score = 43.1 bits (100), Expect = 0.002
Identities = 62/339 (18%), Positives = 110/339 (32%), Gaps = 30/339 (8%)
Query: 943 EESEGFLNPELLETSRKSREPTGVEENKTDS---------LFVLPSRDDATPVRDEPMDA 993
E G +P LL+ +R P+ +++ S + PS+ P +D+P
Sbjct: 2391 ERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSP 2450
Query: 994 ESITFKSVSEKDKRERDKPKAKGDKTKR----KNDGSAVSKKENIVKPAKGPQEKVDGER 1049
F S + + P A SA + PA G GE
Sbjct: 2451 VPSAFSDQS-RCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEP 2509
Query: 1050 ERSPRSEPP-----IKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKP 1104
S ++ P ++ AKE + ++ SSSSS + + + S S+ + P
Sbjct: 2510 PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP 2569
Query: 1105 VKEEKVKKDYSKDVKSEKLTTKEEKAKKP-----------NEKNKPLDNKGEKRKRKTEE 1153
V+ E K + K +E + +P + + + +
Sbjct: 2570 VQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSS 2629
Query: 1154 KGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNR 1213
SSS S KP P+ +P + K E+ S P ++ +R
Sbjct: 2630 SSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSR 2689
Query: 1214 ETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVR 1252
S P ++ S+S + + +G R
Sbjct: 2690 SLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSR 2728
Score = 42.7 bits (99), Expect = 0.003
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 1699 SPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKK-EKKKHKKHKKHKKHKKHAGTEVEL 1757
S SRS +P + + +ES ++++KK +KKKH+ + KK K + T
Sbjct: 178 SSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSK 237
Query: 1758 EKSQKHKHKKKKSKKNKDKEKEKEK 1782
KS+ K K+ +S K + +
Sbjct: 238 RKSKDKKRKRSRSTTPAPKSRRAHR 262
Score = 38.9 bits (89), Expect = 0.045
Identities = 47/151 (31%), Positives = 51/151 (33%), Gaps = 54/151 (35%)
Query: 677 KERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSH------------- 723
K +RRS S S S S SS S SS + S S S S+ S S S S S S
Sbjct: 2602 KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPK 2661
Query: 724 --------------------------SRSYSRSP---------PYPR------RGRGKSR 742
SRS S SP P PR RG R
Sbjct: 2662 PASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRR 2721
Query: 743 NYRSRSRSHGYHRSRSRSPPYRRYHSRSRSP 773
R SRS + R R P H SRSP
Sbjct: 2722 GQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752
Score = 38.5 bits (88), Expect = 0.059
Identities = 26/107 (24%), Positives = 42/107 (39%), Gaps = 11/107 (10%)
Query: 1687 ISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKE----KKKH---- 1738
+ + S SP+ + RS SSS + SKKKK + E K+KH
Sbjct: 174 VRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPT 233
Query: 1739 ---KKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEK 1782
K+ K KK K+ T + + H+ S + D + + +
Sbjct: 234 PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSR 280
Score = 37.7 bits (86), Expect = 0.10
Identities = 107/497 (21%), Positives = 163/497 (32%), Gaps = 92/497 (18%)
Query: 114 LTKTANLAEANASEEDKIKAMMSQS-----GHEYDP---INYMKKPLGPPPPSYTCFRCG 165
+T+T LAE N + ++++A S G +DP K+P PP Y+ R
Sbjct: 118 VTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRES 177
Query: 166 KPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDA 225
K + G R +S+ R K + + K+ PT +
Sbjct: 178 SSSRSPTPKQKKKKKKKDRGRR-SESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKS 236
Query: 226 EAYAIGKKEK------PPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSY 279
+ + KK K P S+ D + + G S
Sbjct: 237 KRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSP 296
Query: 280 CDECIRTALLESD---EHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQL 336
R E D T Q SP+ +Q + ++++ K
Sbjct: 297 SPASGRRG--EGDAPFSEPGTTSTQRPSSPETAT-----KQPSSPYEDKDKDKKEKSATR 349
Query: 337 PPPPP------PIPP-PRPLIQR----NLQPLMRSPISRQ-----------------QDP 368
P P P P PP P PL+ + QPL +P+S++ + P
Sbjct: 350 PSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSP 409
Query: 369 LMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDG- 427
+P +SSS PS ++ + + P S P+ AP +I+ S +S G
Sbjct: 410 EKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREIS---SSPTSKNRSHGR 466
Query: 428 PFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHG----- 482
RD + P+ + S T+ + TP+ G S
Sbjct: 467 AKRDKSHSHTPSRRMGRSRSPATAKRGRSRSR-----------TPTKRGHSRSRSPQWRR 515
Query: 483 -----QLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRH 537
+ + P R +R RPGW S RRG RS RGR
Sbjct: 516 SRSAQRWGRSRSPQRRGRSR-SPQRPGWSRSRNTQ---------RRGRS---RSARRGRS 562
Query: 538 HSERSQRTQGPSLPATP 554
HS RS T+G S TP
Sbjct: 563 HS-RSPATRGRSRSRTP 578
Score = 32.0 bits (71), Expect = 5.6
Identities = 47/240 (19%), Positives = 86/240 (35%), Gaps = 28/240 (11%)
Query: 1552 KRPN-----EETKSVDKNPCKDREKHVLEARNNKESSGNKL----LYILNPPETQVEKEQ 1602
KRPN E K + C + E+ + E ++ K+ L +L KE+
Sbjct: 51 KRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEE 110
Query: 1603 ITGQIDKSTVKPKPQLSHSSRLSSDLTRET--------DEAAFEPDYNESDSESNVSVKE 1654
GQ + V QL+ + ++ R D ++F+P +++
Sbjct: 111 TPGQ--RPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPP 168
Query: 1655 E------ESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSG 1708
+ ESS + S K K K K+ D + R + S RS S S
Sbjct: 169 KPYSLVRESSSSRSPTPKQK---KKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESK 225
Query: 1709 SQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKK 1768
+ + S +S+D K+K+ + K + H+ + + + +S+ K
Sbjct: 226 KRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAK 285
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 117 bits (293), Expect = 1e-25
Identities = 169/930 (18%), Positives = 326/930 (35%), Gaps = 63/930 (6%)
Query: 884 VGGQSHRSRNIGSNYPEKLSARDGHNQ------KDNTKSKEKESENAPGDGK----GNKH 933
+ G S +RNI + ++ Q K N K+ + E N G G+ GNK
Sbjct: 378 IKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKT-QGEVVNIEGPGQKSEPGNK- 435
Query: 934 KKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENK------TDSLFVLPSRDDATPVR 987
H S+G+ + + + S + +P +E+ ++S SR DA+
Sbjct: 436 VGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNS 495
Query: 988 DEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDG 1047
DE D + + +E D + D N+G+ + K + KG + D
Sbjct: 496 DESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSD---SGKGKSDSSDS 552
Query: 1048 ERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKE 1107
+ S S + ++ ++++ S SS D + + S ++ + ++ +
Sbjct: 553 DSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSD 612
Query: 1108 EKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKI 1167
D S D KS+ + K + D+K + + + + D SS
Sbjct: 613 SSDSSD-SSDSKSD--------SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSS 663
Query: 1168 SKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1227
+ + ++ S + D + D + S + + S+++ +
Sbjct: 664 NSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESS-----DSSDSSDSDSSDSSDS 718
Query: 1228 TKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1287
+ S +S++S + + + SS + S++S+ S S + +D
Sbjct: 719 SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSD 778
Query: 1288 TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1347
+ + + ++ N++ + D S D +S + D S SS +S
Sbjct: 779 SSNS----SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD-SSNSSDSSNSSDSS 833
Query: 1348 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ--HEVKSSKNSASSEKGKTKD 1405
N S + +S+ S + S + + SS +S S+E + D
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893
Query: 1406 R-DYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSN 1464
D S + NS+ SN +E N S SS + +SD DS+ +S++
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953
Query: 1465 KDFTPNRDKKTDYDTREYSSSKRRDEKN--ELTRRKDSPSRNKDSASGQKNKPREERDLP 1522
D + + D D+ + +SS D N + + DS + S S + + D
Sbjct: 954 SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Query: 1523 KKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKES 1582
++S S D + D+ ++ + S D + D ++ ++ +S
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS----DSSDSSDS 1069
Query: 1583 SGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYN 1642
S + + + + + D S S SS SSD + +D + N
Sbjct: 1070 SDS------SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSD-SSDSSDSSDSSDSSDSSN 1122
Query: 1643 ESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSR 1702
SDS + + S N S + +S D++ S + S SS S + S
Sbjct: 1123 SSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1182
Query: 1703 SHSPSGSQTRSHSS-------SASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEV 1755
S S S S SS S+ S++S DS + + + +
Sbjct: 1183 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSD 1242
Query: 1756 ELEKSQKHKHKKKKSKKNKDKEKEKEKDDQ 1785
+ S + + E D Q
Sbjct: 1243 SSDSSNSSDSSDSSDSSDSTSDSNDESDSQ 1272
Score = 107 bits (266), Expect = 1e-22
Identities = 146/831 (17%), Positives = 295/831 (35%), Gaps = 42/831 (5%)
Query: 904 ARDGHNQKDNTKSKEKESENAP----GDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK 959
++D N D+ +++ +S++ D GN + + K + +G + ++S
Sbjct: 498 SKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDS 557
Query: 960 SREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKT 1019
S + + +DS S D + D ++S + S + D + D +
Sbjct: 558 SNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSS 617
Query: 1020 KRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQ 1079
+ S SK E+ + + D S S+ ++ + N+ SS S
Sbjct: 618 DSSDSKSDSSKSESDSSDSDSKSDSSD-----SNSSDSSDNSDSSDSSNSSNSSDSSDSS 672
Query: 1080 KDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKP 1139
+ + ++S + + ++ E D S S+ + + + N
Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSS 732
Query: 1140 --LDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEK 1197
D+ + + D SS + + ++ S ++ D +
Sbjct: 733 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSS 792
Query: 1198 DKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTG 1257
D S + + + S + SN+ + S +S+ S + G
Sbjct: 793 DSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS--DSSDG 850
Query: 1258 TEGSSSTLVDYTSTS-STGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQV 1316
++ SS D +++S S+ S S + +D+ + E N+ +++ + +
Sbjct: 851 SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSS----DSNESSNSSDSSDSSN------- 899
Query: 1317 PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKF 1376
S D D + + S+ S S + S+ SN + +
Sbjct: 900 -SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 1377 TKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNE 1436
+ D S+ + SS +S SS + D S ++ + +S + + D N
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Query: 1437 QGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTR 1496
+ S S SS + +SD DS+ +S + D + + D D+ + S S + ++ +
Sbjct: 1019 SDSSNS-SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1077
Query: 1497 RKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNE 1556
DS + S S + + D +S S D + D+ ++
Sbjct: 1078 SSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1137
Query: 1557 ETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKP 1616
+ S D + + ++ ++ +SS + + + + D S
Sbjct: 1138 SSNSSDSSDSSESS----DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1193
Query: 1617 QLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKES 1676
S SS SSD + +D + D ++S S+ S + S N S D D + +S
Sbjct: 1194 DSSDSSD-SSDSSDSSDSS----DSSDSSDSSDSSDSSDSSDSNESSDSSD-----SSDS 1243
Query: 1677 LDTAAVVQVGISRNQSHS-SPSVSPSRSHSPSGSQTRSHSSSASSAESQDS 1726
D++ S + S S S S S S S SG+ + S S S +E DS
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDS 1294
Score = 100 bits (249), Expect = 1e-20
Identities = 171/880 (19%), Positives = 313/880 (35%), Gaps = 83/880 (9%)
Query: 876 TRGRREDYVGGQSHRSRNIGSN-----YPEKLSARDGHNQKDNTKSKEKESENAPGDGKG 930
++G+ G + +IG N Y + D HN+ D K+ + E EN+ G +
Sbjct: 277 SKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSE-ENSAGIPED 335
Query: 931 NKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEP 990
N ++ +K E K E +E++T + V S+D ++
Sbjct: 336 NGSQRIEDTQKLNHRES-----------KRVENRITKESETHA--VGKSQDKGIEIKGPS 382
Query: 991 MDAESITFKSVSEKDKRERDKP-----------KAKGDKTKRKNDGSAVSKKENIVKPAK 1039
+IT K V + ++ + DK K +G+ + G +
Sbjct: 383 SGNRNIT-KEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNT 441
Query: 1040 GPQEKVDGER-----ERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSK 1094
G DG ++S + + P + +E+ D+ S S + + + SK
Sbjct: 442 GSDSNSDGYDSYDFDDKSMQGDDP--NSSDESNGNDDANSESDNNSSSRGDASYNSDESK 499
Query: 1095 SAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK 1154
++K +++ D S T + N N D K + K K++
Sbjct: 500 DNGNGSDSKGAEDD--------DSDSTSDTNNSDSNGNGNNGNDDND-KSDSGKGKSDSS 550
Query: 1155 GVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRE 1214
D D SS + ++ + D+ D + D S + +
Sbjct: 551 --DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSS 608
Query: 1215 TGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSST 1274
+ + S++K S K ES SS K ++ +SS D + +S +
Sbjct: 609 DSSDSSDSSDSSDSKSDSSKSESDSSDSDS---------KSDSSDSNSSDSSDNSDSSDS 659
Query: 1275 GGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVK 1334
S + + + N+ +++ + D S D +S + D
Sbjct: 660 SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDS------SNSSESSDSSDSSDSDSS 713
Query: 1335 STQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKN 1394
+ S+ S N S + +S S + SS +
Sbjct: 714 DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS 773
Query: 1395 SASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSD 1454
S SS+ + D + S ++ + +S + D + + S SS + +SD
Sbjct: 774 SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD--SSDSSDSDSSNSSDSSNSSD 831
Query: 1455 KHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNK 1514
DS+ +S + D + + D +D D+ S S + ++ + +S + S S + +
Sbjct: 832 SSDSSNSSDSSDSSDSSDG-SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN 890
Query: 1515 PREERDLPKKGTGDSK-KSNSSPSRDRKPHDHKA----TYDTKRPNEETKSVDKNPCKDR 1569
+ D DS SNSS S D + + D ++ + S D + D
Sbjct: 891 SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD- 949
Query: 1570 EKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLS--SD 1627
+ ++ N+ +SS + N ++ + + D S S SS S SD
Sbjct: 950 SSNSSDSSNSSDSSNSSDSSDSNSSDSS-DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008
Query: 1628 LTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGI 1687
+ +D + N SDS SN S + S + S D D + +S D++
Sbjct: 1009 SSDSSDSSNSSDSSNSSDS-SNSSDSSDSSDSSDSSDSSD-----SSDSSDSSNSSDSSD 1062
Query: 1688 SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSAS-SAESQDS 1726
S + S SS S S S S S S SS++S S++S DS
Sbjct: 1063 SSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS 1102
Score = 74.7 bits (182), Expect = 7e-13
Identities = 109/696 (15%), Positives = 232/696 (33%), Gaps = 23/696 (3%)
Query: 896 SNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLE 955
SN + + D + D++ S + +S+++ + + S+ N + +
Sbjct: 599 SNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSD 658
Query: 956 TSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 1015
+S S + +DS S D + S + +S D + D
Sbjct: 659 SSNSSNSSDS--SDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS---- 712
Query: 1016 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSS 1075
D + N S+ S N + + S S + + + +D++ SS
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS-SDSSDSSNSSDSSDSS 771
Query: 1076 SSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNE 1135
SS + + S S+ + ++ + D S S + +
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSS-DSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830
Query: 1136 KNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTP 1195
+ N + G D D + S + + ++ S ++ + +
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN 890
Query: 1196 EKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKV 1255
D S + + + N S++ E S ++++S
Sbjct: 891 SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950
Query: 1256 TGTEGSS-----STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDV 1310
+ + SS S D + ++S+ S S + +D+ + + + ++ N++ + D
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS-DSSDSSDSSNSSDSSDS 1009
Query: 1311 IIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPS 1370
S + +S S SS +S + S ++ +S S
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1069
Query: 1371 EKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESN 1430
+ SS +S SS+ + D S ++ + +S + +
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1129
Query: 1431 LDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDE 1490
D + + S S SS + +SD DS+ +S + D + + D D+ S S +
Sbjct: 1130 SDSSDSSDSSNS-SDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 1491 KNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRD-RKPHDHKATY 1549
++ + DS + S S + + D S S+SS S D + D +
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-------SSDSSDSSDSSDSNESSDSSDSS 1241
Query: 1550 DTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGN 1585
D+ + + S D + D + +++ SGN
Sbjct: 1242 DSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGN 1277
Score = 73.6 bits (179), Expect = 2e-12
Identities = 101/680 (14%), Positives = 215/680 (31%), Gaps = 26/680 (3%)
Query: 882 DYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRK 941
D S + + S+ + + + N D++ S + ++ D +
Sbjct: 637 DSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSS 696
Query: 942 GEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSV 1001
+ S S + + + +DS S D + S + S
Sbjct: 697 NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS---NSSDSSDSSNSSDSSDSSDSSNSS 753
Query: 1002 SEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKK 1061
D + D + + + + ++ + S S+
Sbjct: 754 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS 813
Query: 1062 AKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE 1121
++ ++++ SS+SS + + S S+ + + S D
Sbjct: 814 DSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDS 873
Query: 1122 KLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPK 1181
++ + NE + D+ ++ +SS S + +E S
Sbjct: 874 SNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS-DSSESSNSSDN 932
Query: 1182 RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSK 1241
+ D + D + S + + + S N S++ + S +S+ S
Sbjct: 933 SNSSDSSNSSDSSDSSDSSNSSDSSNS---SDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989
Query: 1242 VKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNN 1301
+ + + SS + S+ S+ S S + +D+ + ++
Sbjct: 990 DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS-------DSSDS 1042
Query: 1302 DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK 1361
+++ + D S D +S + S SS +S N S +
Sbjct: 1043 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS 1102
Query: 1362 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1421
+S S + + SS +S SS + D S ++ + +
Sbjct: 1103 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDS 1162
Query: 1422 STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTRE 1481
S + + D ++ N S SS + +SD DS+ +S + D + + D D+ +
Sbjct: 1163 SDSSDSSDSSDS-SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1221
Query: 1482 YSSSKRRDEKNELTRRKDS-----------PSRNKDSASGQKNKPREERDLPKKGTGDSK 1530
S S + NE + DS S + DS+ + E K G G++
Sbjct: 1222 SSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNN 1281
Query: 1531 KSNSSPSRDRKPHDHKATYD 1550
S+S + +H + D
Sbjct: 1282 GSDSDSDSEGSDSNHSTSDD 1301
Score = 65.9 bits (159), Expect = 3e-10
Identities = 115/572 (20%), Positives = 210/572 (36%), Gaps = 63/572 (11%)
Query: 1192 DRTPEKDKISLSAPAKKIKLNRETGKKIG----STENISNTKEPSEKLESTSSKVKQE-- 1245
D+ + + + + + + +E G ++ ST+N E S + E +S++ +
Sbjct: 159 DKNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQIN 218
Query: 1246 -KVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1304
K G +VT G + L + + S G+ + E D + ++ +N++
Sbjct: 219 SKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSK 278
Query: 1305 APAEDVIIMIQVPQSKWDKDDFES---EEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK 1361
Q Q +DD +S + D K P + + T S
Sbjct: 279 G---------QEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENS 329
Query: 1362 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1421
E S++I+ K E + E + +K S + GK++D+ + K +N
Sbjct: 330 AGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEI--KGPSSGNRN 387
Query: 1422 STQPEKESNLDR--------------LNEQGNFKSLSQSSKEARTSDK--HDSTRASSNK 1465
T+ + N + + QG ++ +++ +K H +T + SN
Sbjct: 388 ITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNS 447
Query: 1466 DFTPNRDKKTDYDTREYSS-SKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKK 1524
D YD+ ++ S + D+ N D + N D+ S N D
Sbjct: 448 D---------GYDSYDFDDKSMQGDDPNS----SDESNGNDDANSESDNNSSSRGDASYN 494
Query: 1525 GTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSG 1584
N S S+ + D +T DT + + N D+ ++ +S
Sbjct: 495 SDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDS 554
Query: 1585 NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD--EAAFEPDYN 1642
+ + ++ + S S SSD + +D +++ D +
Sbjct: 555 SDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSS 614
Query: 1643 E----SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSV 1698
+ SDS+S+ S E +SS + SK D + +S D + S N S SS S
Sbjct: 615 DSSDSSDSKSDSSKSESDSSDSDSK--SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSS 672
Query: 1699 SPSRSHSPSGSQTRSHSS----SASSAESQDS 1726
S S S S S S SS S++S+ES DS
Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDS 704
Score = 54.3 bits (129), Expect = 1e-06
Identities = 98/481 (20%), Positives = 163/481 (33%), Gaps = 80/481 (16%)
Query: 1365 KESEPSEKIQKFTKDVSHEIIQHEVKSSKNSA------SSEKGKTKDRDYSV-------L 1411
+E P + D EII++ ++ N++ +S++ TK+ + + L
Sbjct: 180 QEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGL 239
Query: 1412 EKENPEKRKNSTQPEKE--SNLDRLNEQGNFKSLSQSSK--EARTSDKHDSTRASSNKDF 1467
+ + N +++ S D E GN K S +SK E + K D +S +
Sbjct: 240 DNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQ-- 297
Query: 1468 TPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTG 1527
N D K YD + D NE+ K S S + + N + D K
Sbjct: 298 --NSDSKEYYDPEG-----KEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHR 350
Query: 1528 DSKKSNSSPSRDRKPHDHKATYDT----KRPNEETKSVDKNPCKDREKHVLEARNNKESS 1583
+SK+ + +++ + H + D K P+ +++ K K E KE
Sbjct: 351 ESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNE--------GKEDK 402
Query: 1584 GNKLLYI-LNPPETQVEKEQITGQIDKSTVKPKPQLSHSSR------------------- 1623
G + + +TQ E I G KS +P ++ HS+
Sbjct: 403 GQHGMILGKGNVKTQGEVVNIEGPGQKS--EPGNKVGHSNTGSDSNSDGYDSYDFDDKSM 460
Query: 1624 -----LSSDLTRETDEAAFEPDYNES---DSESNVSVKEEESSGNISKDLKDKIVEKAKE 1675
SSD + D+A E D N S D+ N ++ +G+ SK +D + +
Sbjct: 461 QGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSD 520
Query: 1676 S------------LDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAES 1723
+ D G ++ S S S S S S S S S SS++S
Sbjct: 521 TNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDS 580
Query: 1724 QDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1783
S + + + S K SK D K
Sbjct: 581 DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640
Query: 1784 D 1784
D
Sbjct: 641 D 641
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 117 bits (293), Expect = 1e-25
Identities = 150/635 (23%), Positives = 250/635 (39%), Gaps = 93/635 (14%)
Query: 959 KSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKG-- 1016
KS E V E ++ + + T V +E + E K K++ ++ +A+G
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 1017 DKTKRKNDGSAVSKKENIVKP------------------AKGPQEKVDGERERSPRSEPP 1058
++TK A S ++ P AK P E E+ +SP E
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 1059 IKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKS---AKEHQETK-PVKEEKVKKDY 1114
+ ++P+ + KS + + EK +P K +KS AK ++ K PVKEE
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAK-SPAKEEAKSPAEAKSPEKAKSPVKEE------ 611
Query: 1115 SKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTE 1174
+K K KEE AK P E P EK K T+E+
Sbjct: 612 AKSPAEAKSPVKEE-AKSPAEVKSP-----EKAKSPTKEEA------------------- 646
Query: 1175 IVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEK 1234
SP++ P+ E+ ++PEK K + A AK + E K E S K S
Sbjct: 647 ---KSPEKAKSPEKEEA-KSPEKAKSPVKAEAK----SPEKAKSPVKAEAKSPEKAKSPV 698
Query: 1235 LESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVR---KSEEKTDTKRT 1291
E S EK K V+ + E + S + + T SPV+ KS EK +
Sbjct: 699 KEEAKS---PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEK 755
Query: 1292 VIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKN 1351
KT++ + + PA++ + P K+ + +E+VKS + S K +
Sbjct: 756 A-KTLDVKSPEAKTPAKE---EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE 811
Query: 1352 VSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVL 1411
VK P KE E ++++ E E K+ + EK +K +
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAE----EEKAPATPKTEEKKDSKKEEAPKK 867
Query: 1412 EKENP---EKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFT 1468
E P EK++ + + KES ++ E+ ++ K+ T +K + +D
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEE------AEDKKKVPTPEKEAPAKVEVKEDAK 921
Query: 1469 PNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGD 1528
P +KT+ +E +K + E ++ +K++ KD+ + KP E+ K D
Sbjct: 922 PK--EKTEVAKKEPDDAKAK-EPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978
Query: 1529 SKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1563
K + PS KP KA + +++K +K
Sbjct: 979 DKTLSKEPS---KPKAEKAEKSSSTDQKDSKPPEK 1010
Score = 101 bits (251), Expect = 7e-21
Identities = 135/602 (22%), Positives = 230/602 (38%), Gaps = 89/602 (14%)
Query: 1210 KLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTG--TEGSSSTLVD 1267
K +ET TE T+E +E+ E + + + ++ +G + G E S +
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 1268 YTSTSSTGGSPVR---------KSEEKTDTKRTV-IKTMEEYNNDNTAPAEDVIIMIQVP 1317
S SPV+ KS EK + K +K+ E+ + PA++
Sbjct: 509 AASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKS----PAKE-------- 556
Query: 1318 QSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFT 1377
++K + E+E+ KS + S K S K + P+ K PEK P
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE-AKSPEKAKSP-------- 607
Query: 1378 KDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQ 1437
VK S + K K+ S E ++PEK K+ T+ E +S
Sbjct: 608 -----------VKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE------ 650
Query: 1438 GNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDK---KTDYDTREYSSSKRRDEKNEL 1494
K+ S +EA++ +K S + K +P + K K + + E + S ++E
Sbjct: 651 ---KAKSPEKEEAKSPEKAKSPVKAEAK--SPEKAKSPVKAEAKSPEKAKSPVKEEAKSP 705
Query: 1495 TRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRP 1554
+ K S K+ +EE P+K K+ SP + + P K T D K P
Sbjct: 706 EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK-TLDVKSP 764
Query: 1555 NEETKS-------VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQI 1607
+T + DK P K + V E + E + + L PE ++ K++
Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSP-VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV--- 820
Query: 1608 DKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKD 1667
KS VK + + E ++A P E ++E+ ++ K+
Sbjct: 821 -KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879
Query: 1668 KIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSK 1727
VEK KES +V + ++ V +P+ + + +D+K
Sbjct: 880 PAVEKPKES-------KVEAKKEEAEDKKKVPTPEKEAPAKVEVK-----------EDAK 921
Query: 1728 KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1787
K+K + KK K K+ K A + + + K +K K + K K + K K+D K
Sbjct: 922 PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKT 981
Query: 1788 KS 1789
S
Sbjct: 982 LS 983
Score = 90.9 bits (224), Expect = 1e-17
Identities = 110/453 (24%), Positives = 174/453 (38%), Gaps = 48/453 (10%)
Query: 899 PEKLSARDGHNQK--DNTKSKEKESENAPGDGKG--------NKHKKHRKRRKGEESEGF 948
PEK A+ K + KS KE +P + K + K K E
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA 626
Query: 949 LNPELLETSRKSREPTGVEENKTDSLFVLPSRDDA-------TPVRDEPMDAESITFKSV 1001
+P +++ K++ PT EE K+ P +++A +PV+ E E
Sbjct: 627 KSPAEVKSPEKAKSPTK-EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK 685
Query: 1002 SEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGP--QEKVDGERERSPRSEP-- 1057
+E E+ K K + + S V ++ + AK P +E E+ +SP E
Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAK 745
Query: 1058 -PIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSK 1116
P K E KT + KS + ++ +P + AK + + EK K +
Sbjct: 746 SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKE 805
Query: 1117 DVKS-EKLTTKEEKAKKP-NEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVT- 1173
D K+ EK K+E+ K P E+ KP + K ++ +K EE+ ++ K SK E
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865
Query: 1174 --EIVKPSPKRKMEPDTE---------KMDRTPEKDKI---SLSAPAK-------KIKLN 1212
E KP + K EP E K + +K K+ APAK K K
Sbjct: 866 KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 1213 RETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTS 1272
E KK +P+EK E+ K ++ K K + TE + D T +
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE-DDKTLSK 984
Query: 1273 STGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTA 1305
K+E+ + T + K E+ D A
Sbjct: 985 EPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017
Score = 86.7 bits (213), Expect = 2e-16
Identities = 122/515 (23%), Positives = 206/515 (40%), Gaps = 55/515 (10%)
Query: 745 RSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPP 804
+S + + + ++SP + +++SP +SP + P E+E EV
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP----EKEEAKSPAEVKS 580
Query: 805 PYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAG-AQPRPSANRENFSPE 863
P K+ P ++E E K E + K A A+ + E SP
Sbjct: 581 PEKAKS----------PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630
Query: 864 RFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESEN 923
SP +E+ + +S PEK A+ K K++ K E
Sbjct: 631 EVKSPEKAKSP----TKEEAKSPEKAKS-------PEKEEAKSPEKAKSPVKAEAKSPEK 679
Query: 924 APGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDA 983
A K K ++ K E +PE K++ P EE K+ P +++A
Sbjct: 680 AKSPVKAEA--KSPEKAKSPVKEEAKSPE------KAKSPVK-EEAKSPEKAKSPVKEEA 730
Query: 984 -TPVRDE-PMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGP 1041
TP + + P+ E+ + + +K + K+ KT K + A S + + AK P
Sbjct: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE--ARSPADKFPEKAKSP 788
Query: 1042 --QEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK---DEKITGTPRKAHSKSA 1096
+E E+ +SP E K ++E PK + KS ++ + K+ P+KA + A
Sbjct: 789 VKEEVKSPEKAKSPLKEDA-KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 1097 KEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV 1156
+T+ K+ K ++ K+ K+ K+E A + KP ++K E +K + E+K
Sbjct: 848 PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE-----KPKESKVEAKKEEAEDKKK 902
Query: 1157 DKDFESSSMKISKLEVTEIVKPSPKR---KMEPDTEKMDRTPEKDKISLSAPAKKIKLNR 1213
E + +K+EV E KP K K EPD K + + +AP KK
Sbjct: 903 VPTPEKEAP--AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Query: 1214 ETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVK 1248
+ K + + KE + L SK K EK +
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995
Score = 84.7 bits (208), Expect = 7e-16
Identities = 101/460 (21%), Positives = 201/460 (43%), Gaps = 36/460 (7%)
Query: 1344 KPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD--VSHEIIQHEVKSSKNSASSEK- 1400
K SV ++ K +K EK + + +++ T++ V+ E+ + E K +K E+
Sbjct: 428 KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE 487
Query: 1401 -GKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDST 1459
G+ ++ + E ++P + + PEKE+ + K ++S EA++ +K ++
Sbjct: 488 GGEEEEAEGGEEETKSPPAEE-AASPEKEA-------KSPVKEEAKSPAEAKSPEKEEAK 539
Query: 1460 RASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD--SPSRNKDSASGQKNKPRE 1517
+ K +P + K + + + EK E + SP + K A + P E
Sbjct: 540 SPAEVK--SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE 597
Query: 1518 ERDLPKKGTGDSKKSNSSPSRDRKP--HDHKATYDTKRPNE---ETKSVDKNPCKDREKH 1572
+ P+K K+ SP+ + P + K+ + K P + TK K+P K +
Sbjct: 598 AKS-PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656
Query: 1573 VLEARNNKESSGNKLLYILNPPETQ--VEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTR 1630
EA++ +++ +P + + V+ E + + KS VK + + ++
Sbjct: 657 KEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 716
Query: 1631 ETDEAAFEPDYNESDS--ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGIS 1688
++ E A P E+ + ++ VKEE S K K EKAK +LD + +
Sbjct: 717 KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE-----KAKSPEKAK-TLDVKSPEAKTPA 770
Query: 1689 RNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHK 1748
+ ++ S P ++ SP + +S A S +D+K +K+ KK+ K ++ K
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEVKS-PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 1749 KHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
EV++++ K ++K K +EK+ K ++ K
Sbjct: 830 PQ---EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPK 866
Score = 80.9 bits (198), Expect = 1e-14
Identities = 138/661 (20%), Positives = 252/661 (38%), Gaps = 111/661 (16%)
Query: 1029 SKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1088
S+KE ++ + + +V E +E K+AKEE K + ++ E+ T +P
Sbjct: 450 SEKETVIVEEQTEETQVTEEV-----TEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
Query: 1089 RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKG---E 1145
A ++ E + PVKEE +E + ++E+AK P E P K E
Sbjct: 505 -PAEEAASPEKEAKSPVKEEAKSP-------AEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556
Query: 1146 KRKRKTEEKGVDKDFESSSMKISKLEVTEI-VKPSPKRKMEPDTEKMDRTPEKDKISLSA 1204
+ K E K +K+ S ++ E + K K E + + ++P K++ A
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616
Query: 1205 PAKK-IKLNRETGKKIGSTENI-SNTKEPSEKLESTSSKVKQE-----KVKGKVRRKVTG 1257
AK +K ++ ++ S E S TKE ++ E S K+E K K V+ +
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS 676
Query: 1258 TEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVP 1317
E + S + + SPV++ + + ++ +K + +P ++
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE-------- 728
Query: 1318 QSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKES--EPSEKIQK 1375
++K + +E+ KS + S K K + K S K P KE P++K +
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKA----KTLDVK-SPEAKTPAKEEARSPADKFPE 783
Query: 1376 FTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLN 1435
K ++ EVKS + + S K D EKE P+K + + ++E
Sbjct: 784 KAKSP----VKEEVKSPEKAKSPLK-----EDAKAPEKEIPKKEEVKSPVKEEEK----- 829
Query: 1436 EQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELT 1495
Q K K + +A + TP ++K +D K E
Sbjct: 830 --------PQEVKVKEPPKKAEEEKAPA----TPKTEEK-------------KDSKKEEA 864
Query: 1496 RRKDSPS-RNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRP 1554
+K++P + ++ KP+E + KK + KK +P ++
Sbjct: 865 PKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAP------------- 911
Query: 1555 NEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKP 1614
K K K +EK + + ++ + P EK++ +K K
Sbjct: 912 ---AKVEVKEDAKPKEKTEVAKKEPDDAKAKE-------PSKPAEKKEAAP--EKKDTKE 959
Query: 1615 KPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAK 1674
+ + ++ + D+ + ++ +E K E+SS KD K EKA
Sbjct: 960 EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE-----KAEKSSSTDQKDSKPP--EKAT 1012
Query: 1675 E 1675
E
Sbjct: 1013 E 1013
Score = 79.0 bits (193), Expect = 4e-14
Identities = 133/653 (20%), Positives = 238/653 (36%), Gaps = 91/653 (13%)
Query: 601 PPGFPPAPANLSTPWVSSG-----VQTAHSNTI---PTTQAPPLSREEFYREQRRLKEEE 652
P G P P+ + V S V+ + T+ T+ ++ E E++ KEEE
Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEE 482
Query: 653 KKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRS 712
K+ + E E +E +KSP + S + + + +
Sbjct: 483 GKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542
Query: 713 RSYSRSFSRSHSRSYSRSPPY---PRRGRGKS-RNYRSRSRSHGYHRSRSRSPPYRRYHS 768
S ++S ++ ++SPP P + KS +S ++ + ++SP +
Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602
Query: 769 RSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYR 828
+++SP +SP + P E + EV P KA + + P + +
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSP----AEVKSPE--KAKSPTKEEAKSPEKAKSPE 656
Query: 829 EWERKYREWYEKYYKGYAAGAQPRPS-ANRENFSPERFLPLNIRNSPFTRGRREDYVGGQ 887
+ E K E + K A + S E SPE+ SP +
Sbjct: 657 KEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK------AKSPVKEEAKS------ 704
Query: 888 SHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEG 947
PEK + K+ KS EK + K + K + + + E
Sbjct: 705 -----------PEKAKSP----VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK 749
Query: 948 FLNPELLET----SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSE 1003
+PE +T S +++ P E F ++ +PV++E E +
Sbjct: 750 AKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAK---SPVKEEVKSPEKAKSPLKED 806
Query: 1004 KDKRERDKPKAKGDKTKRKNDGSA----VSKKENIVKPAKGP-----QEKVDGERERSPR 1054
E++ PK + K+ K + V + + K P +EK D ++E +P+
Sbjct: 807 AKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPK 866
Query: 1055 SEPPIKKAKE------ETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE 1108
E P K +E E PK ++ +D+K TP K + ++ KP ++
Sbjct: 867 KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT 926
Query: 1109 KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL----DNKGEKRKRKTEEKGVDKDFESSS 1164
+V K D K+++ KP EK + D K EK K+ E+ + +
Sbjct: 927 EVAKKEPDDAKAKE-------PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979
Query: 1165 MKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGK 1217
+SK +PS +P EK +++ D+ P K + GK
Sbjct: 980 KTLSK-------EPS-----KPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 59.7 bits (143), Expect = 2e-08
Identities = 73/316 (23%), Positives = 133/316 (42%), Gaps = 24/316 (7%)
Query: 1489 DEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKAT 1548
+E+ E T+ + + ++ + ++ EE ++ G +++ S P+ + + +A
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 1549 YDTKRPNEETKSVD--KNPCKDREKHVLEARNNKESSGNKLLYILNPPETQV-EKEQITG 1605
K EE KS K+P K+ K E ++ +++ +PPE + EKE+
Sbjct: 518 SPVK---EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574
Query: 1606 QID-KSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDS--ESNVSVKEEESSGNIS 1662
+ KS K K ++ S ++ E A P E+ S E+ VKEE S
Sbjct: 575 PAEVKSPEKAKSPAKEEAK--SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS---- 628
Query: 1663 KDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSAS--- 1719
+ K EKAK T + + SP ++ SP ++ +S + S
Sbjct: 629 -PAEVKSPEKAKSP--TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK 685
Query: 1720 -SAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVE--LEKSQKHKHKKKKSKKNKDK 1776
A+S + K K+E K +K K K + + + + +++ K K K K + K
Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAK 745
Query: 1777 EKEKEKDDQKVKSVTV 1792
EK K +K K++ V
Sbjct: 746 SPEKAKSPEKAKTLDV 761
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 110 bits (274), Expect = 2e-23
Identities = 235/1191 (19%), Positives = 436/1191 (36%), Gaps = 184/1191 (15%)
Query: 629 PTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRS-- 686
P T +PP E ++ KE+ K K +++E T D ++++ +++R + S S
Sbjct: 261 PRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPA 320
Query: 687 ---KSPYSGSSYSRSSYTYS-------KSRSGSTRSRSYSRSFSRSHSRSYSRSPPY--- 733
SP S +S SS + S R T S SY R+ + RS S P +
Sbjct: 321 GQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS 380
Query: 734 -PRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETE 792
P+R + R +RS R G H S + R H R + R + + R + E +
Sbjct: 381 SPQRKQSPPR-HRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQD 439
Query: 793 REYFNRYREVPPPYD---------------------------MKAYYGRSVDFRDPFEKE 825
+ +R+ P D M+ Y + + RDP +
Sbjct: 440 QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSR 499
Query: 826 R------YREWERK--------YREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIR 871
YR+ E + Y E Y + + R E+ + R IR
Sbjct: 500 STRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESR---SEIR 556
Query: 872 NSPF--------------TRGRREDYVGGQS-----HRSRNIGSNYPEKLSARDGHNQKD 912
N +RG R + S H S S+YPE RD + ++D
Sbjct: 557 NDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE----RDRYPERD 612
Query: 913 N-TKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKT 971
N ++++ E G+ +++ +R N EL R+ +++
Sbjct: 613 NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRR 672
Query: 972 DSLFVLPSRD-----DATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGS 1026
D R+ + R+ D E + + + RER++ + K +R D
Sbjct: 673 DERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRD 732
Query: 1027 AVSKKE-----NIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKD 1081
++E + K + +E+ + ERER E ++ +E + D + +D
Sbjct: 733 HDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWED 792
Query: 1082 E--------------KITGTPRKAHS--KSAKEHQ---ETKPVKEEKVKKDYSKD----- 1117
+ + PR H KS K ++ P + K ++++S D
Sbjct: 793 KDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYN 852
Query: 1118 ----------VKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSM-- 1165
+ S+ + +E ++ P+ + + ++ RK E K + +E +
Sbjct: 853 SGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKE 912
Query: 1166 KISKL----EVTEIVKPSPKRKME-------PDTEKMDRTPEKDKISLSAPAKKIKLNRE 1214
K+S + E TEI++ S R + D E DR +++K K IK +E
Sbjct: 913 KVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE 972
Query: 1215 TGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSST 1274
I NI T E + + K +++K K R+K G S S
Sbjct: 973 DDVGI-ERGNIETTSEDGQVF--SPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKR 1029
Query: 1275 GGSPVRKSEEKTDTKRTVIKTMEEYNN--DNTAPAEDVIIMIQVPQSKWDKDDFESEEED 1332
G TK +++ N +++ ED + D+ + E
Sbjct: 1030 G-----PRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHT 1084
Query: 1333 VKSTQPISSVGKPASVI---KNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEV 1389
+T P S+ +S++ V+T + V + + T ++
Sbjct: 1085 ATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPT 1144
Query: 1390 KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKE 1449
++ N+ ++E K V + E P Q K + R + G+ +S +
Sbjct: 1145 NTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSG 1204
Query: 1450 ARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSS-----KRRDEKNELTRRKDSPSRN 1504
S +DS S + R + RE + S +R+ ++L R + S S +
Sbjct: 1205 RLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTS 1264
Query: 1505 KD-----SASGQKNKPREERDL-PKKGTGDSKKSNSSPSRDRKPHDHKATYDTK--RPNE 1556
D S S +++ P +R + + G+ DS+ + RDR HD + + + R E
Sbjct: 1265 SDRQDSRSHSSRRSSPESDRQVHSRSGSFDSR--DRLQERDRYEHDRERERERRDTRQRE 1322
Query: 1557 ETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQ-ITGQIDKSTVKPK 1615
+ DK+ ++R++ L R + + + E+E+ I+ +++ + +
Sbjct: 1323 WDRDADKDWPRNRDRDRLRERERERERDKR-------RDLDRERERLISDSVERDRDRDR 1375
Query: 1616 PQLSHSSRLSSDLTRETD-EAAFEPDYNESDSESNVSVKEEESSGNISKDL 1665
+ SS++ S E E E D ES S ++++ +E + KDL
Sbjct: 1376 DRTFESSQIESVKRCEAKLEGEHERDL-ESTSRDSLALDKE----RMDKDL 1421
Score = 107 bits (267), Expect = 1e-22
Identities = 227/1171 (19%), Positives = 439/1171 (37%), Gaps = 213/1171 (18%)
Query: 675 IQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRS---- 730
+ K RR+ + S S+ R S S + + + R++ ++ + Y +
Sbjct: 1 MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRNWLKTGNCLYGNTCRFV 60
Query: 731 -PPYPRRGRGKSRNYR-SRSRSHGYHRSRSRSP-------PYRRYHSRSRSP---QAFRG 778
P PR G+G S NYR S R G R R ++ P +R S SP ++ RG
Sbjct: 61 HGPSPR-GKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRG 119
Query: 779 QSPNKRNV-------PQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWE 831
+ K ++ P+ E E + R+ D+ Y + +K + RE
Sbjct: 120 RHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ-RELM 178
Query: 832 RKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRS 891
+ +E EK + + P R SP ++R S + R+
Sbjct: 179 KLEQENMEKREE-IIIKKEVSPEVVRSKLSPSP----SLRKSSKSPKRKSS--------- 224
Query: 892 RNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNP 951
P+ SA + K ++ + ++P + K ++ ++KG + P
Sbjct: 225 -------PKSSSA--------SKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPP 269
Query: 952 --ELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRER 1009
E + +K +E V++ + +RD RD E+ + +R
Sbjct: 270 IPEDIALGKKYKEKYKVKDRIEEK-----TRDGKDRGRD-------------FERQREKR 311
Query: 1010 DKPKAKGDKTKR------KNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAK 1063
DKP++ + ++ S+ +I + + P+ K PP++++
Sbjct: 312 DKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSA 371
Query: 1064 EETPK---TDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE-KVKKDYSKDVK 1119
P + + S + + R H ++++ H +E+ + K+D KD +
Sbjct: 372 SPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSR 431
Query: 1120 SEKLTTKEEKAKKPNEKNK-PLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKP 1178
E+ +++ + + + ++ P D + + R T ++ +D S M+ S+
Sbjct: 432 EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRD--SRDMRDSR--------- 480
Query: 1179 SPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGS-------------TENI 1225
R DT K R P + + A + + R+T +K + E
Sbjct: 481 -EMRDYSRDT-KESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538
Query: 1226 SNTKEPSEKLESTSSKVKQEKVKGKVRRKVT-----GTEGSSSTLVDYTSTSSTGGSPVR 1280
S T+ +E + S+++ +++ G+ R +V G+ GS + +D S++S
Sbjct: 539 SRTEIRNESRNESRSEIRNDRM-GRSRGRVPELPEKGSRGSRGSQIDSHSSNSN------ 591
Query: 1281 KSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPIS 1340
+ +T+ + + DN A D + ++D ++ E D + + PI
Sbjct: 592 -YHDSWETRSSYPERDRYPERDNRDQARDS----SFERRHGERDRRDNRERDQRPSSPIR 646
Query: 1341 SVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEK 1400
G+ E E E+ ++ D V ++ + E+
Sbjct: 647 HQGR-------------------NDELERDERREERRVD--------RVDDRRDERARER 679
Query: 1401 GKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDK-HDST 1459
+ ++RD E+E +R+ + EKE L+R + + + R D+ HD
Sbjct: 680 DRERERDR---ERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRE 736
Query: 1460 RASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREER 1519
R ++ +R+K+ + + E + R+ + E R ++ + ++ + E++
Sbjct: 737 R---ERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDK 793
Query: 1520 DLPKKGTGDSKKSNSSPSRDRKPHD-HKATYDTKRPNEETKSVDKNPCKDREKHVLEARN 1578
D KG D ++ DR P D H KR E + K R +H ++
Sbjct: 794 D---KGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSD- 849
Query: 1579 NKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE 1638
N + + EK ++ Q+ V+P+ S S S LT + E
Sbjct: 850 -----------AYNSGDDKNEKHRLLSQV----VRPQESRSLSP---SHLTEDRQGRWKE 891
Query: 1639 PDYNESDSESNVSVKEEESSGNISKDLKDKI--VEKAKESLDTAAVVQVGISRNQSHSSP 1696
D ES+ +E+E LK+K+ V+K +E + +++ R Q
Sbjct: 892 EDRKPERKESSRRYEEQE--------LKEKVSSVDKQREQTE---ILESSRMRAQDIIGH 940
Query: 1697 SVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVE 1756
S R S R+H D KKK K +KK KK K+ + E
Sbjct: 941 HQSEDRETSD-----RAH----------DENKKKAKIQKKPIKKKKEDDVGIERGNIETT 985
Query: 1757 LEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1787
E Q KK + KK+ +K+++K K D +
Sbjct: 986 SEDGQVFSPKKGQKKKSIEKKRKKSKGDSDI 1016
Score = 94.7 bits (234), Expect = 7e-19
Identities = 185/978 (18%), Positives = 362/978 (37%), Gaps = 110/978 (11%)
Query: 642 YREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKE-----RRRSFSRSKSPYSGSSYS 696
YR+ R ++ +K+ E + + + + + + E R S S ++ G S
Sbjct: 507 YRD-REGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRG 565
Query: 697 RSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRS 756
R K GS S+ S S + ++ S+ YP R R R+ R ++R + R
Sbjct: 566 RVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER- 624
Query: 757 RSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQG---ETEREYFNRYREVPPPYDMKAYYG 813
R+ R R R Q P+ QG E ER+ R V D +
Sbjct: 625 --------RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERA 676
Query: 814 RSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNS 873
R D ++ER RE ER+ EK + A+ R + ER +
Sbjct: 677 RERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRE 736
Query: 874 PFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENA-----PGDG 928
R+ + R E+ R+ +++ + ++KE E G
Sbjct: 737 RERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKG 796
Query: 929 KGNKHKKH---------------RKRRKGEESEGFLNPELLETSRKSREP------TGVE 967
+ ++ +K RK +K +EG +P R+ P +G +
Sbjct: 797 RDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDD 856
Query: 968 ENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSA 1027
+N+ L R + E + E K ER + + ++ + K S+
Sbjct: 857 KNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSS 916
Query: 1028 VSKKEN---IVKPAKGPQEKVDG-----ERERSPRS-----------EPPIKKAKEETPK 1068
V K+ I++ ++ + + G +RE S R+ + PIKK KE+
Sbjct: 917 VDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVG 976
Query: 1069 TDNTKSSSSSQKDEKIT---GTPRKAHSKSAKEHQETKPVKEEKVKKDYSKD--VKSEKL 1123
+ ++S+ + + G +K+ K K+ + + +E+ + K ++ +
Sbjct: 977 IERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPI 1036
Query: 1124 TTKEEKAKKPNEKNKPLDNKGEKRKRKTEE---KGVDKDFESSSMKISKLEVTEIVKPSP 1180
TTKEE + N KN L++ +K + + V E + + + T PSP
Sbjct: 1037 TTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSP 1096
Query: 1181 KRKMEPD-----TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL 1235
+ P T P + +A A + T + N +N +E
Sbjct: 1097 LSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDS 1156
Query: 1236 ESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKT 1295
+ + EKV+ VT + +D +SS G + R + T +
Sbjct: 1157 HRKCHRTRVEKVETP---HVTIEDAQHRKPMDQKRSSSLGSN--RSNRSHTSGR------ 1205
Query: 1296 MEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTK 1355
+ +ND+ + D K S D + T+ + G+ S I +
Sbjct: 1206 LRSPSNDSAHRSGD--------DQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRG 1257
Query: 1356 PSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKEN 1415
+ +++ S ++ + + ++ S++ + + + ++RD ++E
Sbjct: 1258 EPSRSTSSDRQDSRSHSSRRSSPESDRQV------HSRSGSFDSRDRLQERDRYEHDRER 1311
Query: 1416 PEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKH---DSTRA---SSNKDFTP 1469
+R+++ Q E + + D+ + + + + R DK D R S + +
Sbjct: 1312 ERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDR 1371
Query: 1470 NRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPK-KGTGD 1528
+RD+ +++ + S KR + K E +D S ++DS + +K R ++DL +G +
Sbjct: 1372 DRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLA--LDKERMDKDLGSVQGFEE 1429
Query: 1529 SKKSNSSPSRDRKPHDHK 1546
+ KS + S + + K
Sbjct: 1430 TNKSERTESLEAGDDESK 1447
Score = 79.7 bits (195), Expect = 2e-14
Identities = 144/804 (17%), Positives = 300/804 (37%), Gaps = 104/804 (12%)
Query: 1005 DKRERDKPKAKGDKT---KRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKK 1061
D RER K K + T KR + S+ ++ + +E + +ER+P SE +
Sbjct: 84 DLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVE 143
Query: 1062 AKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKV-KKDYSKDVKS 1120
+ +DN + + + +K + K QE +EE + KK+ S +V
Sbjct: 144 WETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVR 203
Query: 1121 EKLTTK---EEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVK 1177
KL+ + +K P K+ P + K+ RKT + + K ++ +
Sbjct: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRT 263
Query: 1178 PSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLES 1237
PSP + D + EK K+ +I+ GK G + +E +K S
Sbjct: 264 PSPPPPIPEDIALGKKYKEKYKVK-----DRIEEKTRDGKDRG--RDFERQREKRDKPRS 316
Query: 1238 TSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTME 1297
TS G+ ++ SSS S GS +++ KRT
Sbjct: 317 TSPA-------GQHHSPISSRHHSSS---------SQSGSSIQRHSPSPRRKRT---PSP 357
Query: 1298 EYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPS 1357
Y T P P + ++ + P+ G+ + T S
Sbjct: 358 SYQRTLTPPLR----RSASPYPSHSLSSPQRKQSPPRHRSPMREKGRH----DHERTSQS 409
Query: 1358 NIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPE 1417
+ ++ +E ++ ++ KD E E + ++S+ + + RD ++ +
Sbjct: 410 HDRRHERREDTRGKRDRE--KDSREE---REYEQDQSSSRDHRDDREPRD----GRDRRD 460
Query: 1418 KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDY 1477
R + E + D + + + S+ +KE+R STR + + RD
Sbjct: 461 ARDTRDRRELRDSRD-MRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKE 519
Query: 1478 DT-----REYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREER--DLPKKGTGDSK 1530
DT R Y + R+E + R +S + ++ + R +LP+KG+ S+
Sbjct: 520 DTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSR 579
Query: 1531 KSN-SSPSRDRKPHDHKATYDT-----KRPNEETKSVDKNPCKDREKHVLEARNNKESSG 1584
S S S + HD T + + P + + ++ +R + R+N+E
Sbjct: 580 GSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQ 639
Query: 1585 NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNES 1644
P + + + ++++ + + ++ + RE D E
Sbjct: 640 R--------PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRE------RER 685
Query: 1645 DSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSH 1704
D E + E +D+ EK +E + R ++ +
Sbjct: 686 DRERERERERE----------RDREREKERE-----------LERERARERER-EREKER 723
Query: 1705 SPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHK 1764
+ R H +D +K+++++ +++ ++ ++ ++ ++ E E E+ + +
Sbjct: 724 DRERDRDRDHDRERERERERDREKEREREREERERERERERERER----ERERERERARE 779
Query: 1765 HKKKKSKKNKDKEKEKEKDDQKVK 1788
K++ ++ ++K+K +DD++ K
Sbjct: 780 RDKERERQRDWEDKDKGRDDRREK 803
Score = 72.8 bits (177), Expect = 3e-12
Identities = 145/766 (18%), Positives = 285/766 (37%), Gaps = 110/766 (14%)
Query: 1039 KGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPR-KAHSKSAK 1097
+ P+ RER + + P+ NT+ SSS + E G R K K K
Sbjct: 76 RSPERPTGDLRERMKNKRQDV----DTEPQKRNTEESSSPVRKESSRGRHREKEDIKITK 131
Query: 1098 EHQETKPVKEEKVKKDYSKDVKSE---------KLTTKEEKAKKPNEKNKPLDNKGEKRK 1148
E T +EE V+ + ++D +L+ + ++ K E K EKR+
Sbjct: 132 ER--TPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKRE 189
Query: 1149 RKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKK 1208
+K V + S K+S SPKRK P + + K ++S+P
Sbjct: 190 EIIIKKEVSPEVVRS--KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTS-AVSSPLLD 246
Query: 1209 IKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDY 1268
+ N +T + S + T P + + K+ K K KV+ ++ +
Sbjct: 247 QQRNSKTNQ---SKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIE----------EK 293
Query: 1269 TSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN-----NDNTAPAEDVIIMIQVPQSKWDK 1323
T G + EK D R+ + ++ + +++ I P + +
Sbjct: 294 TRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKR 353
Query: 1324 DDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHE 1383
S + + T P+ ++ S PS+ + P+++ P + H+
Sbjct: 354 TPSPSYQRTL--TPPLR---------RSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHD 402
Query: 1384 IIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSL 1443
HE S + DR + E E + EK+S +R EQ
Sbjct: 403 ---HERTSQSH----------DRRH-----ERREDTRGKRDREKDSREEREYEQDQ---- 440
Query: 1444 SQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSR 1503
SS++ R D + +D RD++ D+R+ S+ + + T+ P
Sbjct: 441 -SSSRDHR--DDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRD 497
Query: 1504 NKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1563
++ + + RE RD +K ++S S R+ + T E++S +
Sbjct: 498 SRSTRDAHDYRDREGRDTHRKEDTYPEESRSY-GRNHLREESSRTEIRNESRNESRSEIR 556
Query: 1564 NPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSR 1623
N R + + K S G++ QID SHSS
Sbjct: 557 NDRMGRSRGRVPELPEKGSRGSR-----------------GSQID----------SHSSN 589
Query: 1624 LSSDLTRETDEAAFEPD-YNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAV 1682
+ + ET + E D Y E D+ +SS +D+ + ++ ++ +
Sbjct: 590 SNYHDSWETRSSYPERDRYPERDNRDQA----RDSSFERRHGERDRRDNRERDQRPSSPI 645
Query: 1683 VQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHK 1742
G RN R + R + E + +++++++E+++ ++ +
Sbjct: 646 RHQG--RNDELERDERREERRVDRVDDR-RDERARERDRERERDRERERERERERDRERE 702
Query: 1743 KHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
K ++ ++ E E E+ +K + +++ ++ D+E+E+E++ + K
Sbjct: 703 KERELERERARERERER-EKERDRERDRDRDHDRERERERERDREK 747
Score = 60.5 bits (145), Expect = 1e-08
Identities = 81/403 (20%), Positives = 156/403 (38%), Gaps = 60/403 (14%)
Query: 1399 EKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDS 1458
E+ K K +D E + ++S+ KES+ R E+ + K +KE + ++
Sbjct: 87 ERMKNKRQDVDT-EPQKRNTEESSSPVRKESSRGRHREKEDIKI----TKERTPESEEEN 141
Query: 1459 TRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREE 1518
+N+D + N D DY KR+ + EL + + ++ +K E
Sbjct: 142 VEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEV 201
Query: 1519 RDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARN 1578
+ +KS+ SP R P A+ + + +T +V +P D++ RN
Sbjct: 202 VRSKLSPSPSLRKSSKSPKRKSSPKSSSAS----KKDRKTSAVS-SPLLDQQ------RN 250
Query: 1579 NKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE 1638
+K + K P + ++ G+ K K K ++ +R D R+ + +
Sbjct: 251 SKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREK 310
Query: 1639 PDYNESDS-----ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSH 1693
D S S S +S + SS + Q H
Sbjct: 311 RDKPRSTSPAGQHHSPISSRHHSSSSQSGSSI-------------------------QRH 345
Query: 1694 SSPSVSPSRSHSPSGSQTRSHSS----SASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1749
S SP R +PS S R+ + SAS S ++K+ +H+ + K
Sbjct: 346 SP---SPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHD 402
Query: 1750 HAGTEVELEKSQKHKHKKK---KSKKNKDKEKEKEKDDQKVKS 1789
H T +S +H+++ + K++++K+ +E++ ++ +S
Sbjct: 403 HERT----SQSHDRRHERREDTRGKRDREKDSREEREYEQDQS 441
Score = 42.4 bits (98), Expect = 0.004
Identities = 99/446 (22%), Positives = 163/446 (36%), Gaps = 47/446 (10%)
Query: 571 TLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPT 630
T P P P S PP A + P A +T + +S + + S T
Sbjct: 1086 TATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTN 1145
Query: 631 TQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPY 690
T + E+ +R+ R + E+ E + ++ K + ++R S ++S
Sbjct: 1146 TTNNTFANEDSHRKCHRTRVEKV------ETPHVTIEDAQHRKPMDQKRSSSLGSNRSNR 1199
Query: 691 SGSS-YSRSSYTYSKSRSGSTRS--RSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSR 747
S +S RS S RSG +S + S SR ++ S R+ R
Sbjct: 1200 SHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEP 1259
Query: 748 SRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYD 807
SRS R SRS RR S R S + R+ Q E +R +R RE
Sbjct: 1260 SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ-ERDRYEHDRERERERRDT 1318
Query: 808 MKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLP 867
+ + R D P ++R R ER+ +K R +RE ER +
Sbjct: 1319 RQREWDRDADKDWPRNRDRDRLRERERERERDK-----------RRDLDRER---ERLIS 1364
Query: 868 LNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGD 927
++ R R D R R S+ E + + + ++ + E S ++
Sbjct: 1365 DSVE-----RDRDRD-------RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLAL 1412
Query: 928 GKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPS--RDDATP 985
K K + EE+ E LE G +E+K D L S + P
Sbjct: 1413 DKERMDKDLGSVQGFEETNKSERTESLE--------AGDDESKLDDAHSLGSGAGEGYEP 1464
Query: 986 VRDEPMDAESITFKSVSEKDKRERDK 1011
+ D+ +D E + + +D+++ +K
Sbjct: 1465 ISDDELD-EILAGDAEKREDQQDEEK 1489
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 109 bits (273), Expect = 2e-23
Identities = 189/865 (21%), Positives = 349/865 (40%), Gaps = 109/865 (12%)
Query: 980 RDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAK 1039
R TP+R P + +T S E ++ ++K K K+ S+ S +N KP K
Sbjct: 620 RVKTTPLR-RPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDN-PKPNK 677
Query: 1040 GPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEH 1099
P+ K +++ S+ + KE + + S SS D I + H+ +
Sbjct: 678 LPKSKQSETVDQNSDSDEMLAILKEVS------RMSHSSSSDTDIN----EIHTNHKTLY 727
Query: 1100 Q-ETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDK 1158
+T+ K++K K+ TK+ K+ K + +K +KR+ ++E D
Sbjct: 728 DLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISK------KKRQTQSESSNYDS 781
Query: 1159 DFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK 1218
+ E +SK+ K K P+T+ D + E +K S + N +T ++
Sbjct: 782 ELEKEIKSMSKIGAARTTK-----KRIPNTKDFDSS-EDEKHSKKGMDNQGHKNLKTSQE 835
Query: 1219 IGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTL--VDYTS--TSST 1274
GS+++ + K+ E S V ++ ++R ++ + +S++ VD S S
Sbjct: 836 -GSSDD-AERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSF 893
Query: 1275 GGSPVRK-SEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDV 1333
VRK +E K +K KT ++ + + AE + K D+ D SE++
Sbjct: 894 TSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL--------KKDQSDETSEDDKK 945
Query: 1334 KSTQPISSVGKPASVIKNV-------STKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ 1386
+S + KP+ K V + K PE+E K K + +
Sbjct: 946 QSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH--FPKGIKQIKNGTTD 1003
Query: 1387 HEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK-NSTQPEKESNLDRLNEQGNFKSLSQ 1445
E KS K + K K + DY+ EK + +S++ +K N E+ K L +
Sbjct: 1004 GEKKSKKIRDKTSKKKDELSDYA--EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGK 1061
Query: 1446 SSKEARTSDKHDSTRASSNKDFTPNRDKKT---DYDTREYSSSKRRDEKNELTRRKDSPS 1502
SS++ + D+ + S +D + DK+ + R SSKR T+ S S
Sbjct: 1062 SSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRN------TKEIQSGS 1115
Query: 1503 RNKDSA-SGQKNKPREERDLPKKGT---GDSKKSNSSPSRDRKPHDHKATYDTKRPNEET 1558
+ D+ S + NK +++R KK + K+++ S RK D ++ + +++
Sbjct: 1116 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1175
Query: 1559 KSVDKNPCKDR------EKHVLEARNNK-ESSGNKLLYIL-----------NPPETQVEK 1600
S+ + ++ E VL + +SSG++ L N PE ++ K
Sbjct: 1176 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1235
Query: 1601 EQITGQI-------DKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
+ + +I + + +P+ + DE A +ESDS+S S K
Sbjct: 1236 KMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKK 1295
Query: 1654 EEE-----------SSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSR 1702
S G ++ K K E + V S + VS
Sbjct: 1296 PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEV 1355
Query: 1703 SHSPSGSQTRSHSSS-ASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQ 1761
S S + R+ S+ A E+Q S K+KKK+ + K ++ + E+ +
Sbjct: 1356 SESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS-------EEEE 1408
Query: 1762 KHKHKKKKSKKNKDKEKEKEKDDQK 1786
+ K ++++ ++ +++E+E E DD K
Sbjct: 1409 EEKEEEEEEEEEEEEEEEDENDDSK 1433
Score = 93.2 bits (230), Expect = 2e-18
Identities = 177/925 (19%), Positives = 362/925 (39%), Gaps = 57/925 (6%)
Query: 901 KLSAR--DGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSR 958
KLS + D + N ++E+ + + G +K + + + L+ +++ S
Sbjct: 425 KLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIV--SV 482
Query: 959 KSREPTGVEENKTDSLFVLPSRD---DATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 1015
S P + EN ++ V S D D + ++ +++ S+ ++S KD R K K
Sbjct: 483 PSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKL-NISSKDNRGGIKSKTT 541
Query: 1016 GDKTKRKNDG-SAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDN--- 1071
TK + VS + +K A + D + +S P ++K +DN
Sbjct: 542 AKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHL 601
Query: 1072 TKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAK 1131
++ S +E + + + ET PV ++ + +KL+ K
Sbjct: 602 VENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 661
Query: 1132 KPNEKNKPLDN-KGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEK 1190
K N + +DN K K + + + VD++ +S M EV+ + S + D +
Sbjct: 662 KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRM---SHSSSSDTDINE 718
Query: 1191 MDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGK 1250
+ T K L A K + K S + K S K S K +Q + +
Sbjct: 719 I-HTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 777
Query: 1251 VRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDV 1310
E S + + T+ P K + ++ ++ K M+ + N +++
Sbjct: 778 NYDSELEKEIKSMSKIGAARTTKKR-IPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEG 836
Query: 1311 IIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKE-SEP 1369
+ K +++ F S E V I + + S + K KE S
Sbjct: 837 --SSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 894
Query: 1370 SEKIQKF--TKDVSHEIIQHEVKSSKNSAS--SEKGKTKDRDYSVLEKENPEKRKNSTQP 1425
S +++K TK+ S + K ++ S +EK KD+ E + + +K + +
Sbjct: 895 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK 954
Query: 1426 EKESNLDR--LNEQGNFKSLSQSSKEARTSDK--HDSTRASSNKDFTPNRDKKTDYDTRE 1481
+K S+ + + + ++S S +++ ++ H K+ T + +KK+ R+
Sbjct: 955 KKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSK-KIRD 1013
Query: 1482 YSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKP----REERDLPKKGTGDSKKSNSSPS 1537
+SK++DE ++ + + DS+ +K+K RE++ G K+ + S S
Sbjct: 1014 -KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSS 1072
Query: 1538 RDRKPHDHKATYDTKRP--NEETKSVDKNPCKDREKHVLEARNNKE-SSGNKLLYILNPP 1594
K Y K N K + + ++R +++ RN KE SG+
Sbjct: 1073 DTEK-------YSMKEDGCNSSDKRLKRIELRER-RNLSSKRNTKEIQSGSSSSDAEESS 1124
Query: 1595 ETQVEKEQITGQIDKST-VKPKPQLS---HSSRLSSDLTRETDEAAFEPDYNESDSESNV 1650
E +K+Q T K+ VK K + S + R +D+T + + D N S+
Sbjct: 1125 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1184
Query: 1651 SVKEEESSGNISKDLKDKIVEKA-KESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGS 1709
K + + N+ + + E+L + V V + + ++ +
Sbjct: 1185 EQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1244
Query: 1710 QTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKK 1769
S +S E ++ KK+ K+ ++ + + + ++ E K +++H+ +
Sbjct: 1245 NLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR 1304
Query: 1770 SK------KNKDKEKEKEKDDQKVK 1788
K ++ +++K K K+ ++VK
Sbjct: 1305 HKLTVSDGESGEEKKTKPKEHKEVK 1329
Score = 83.6 bits (205), Expect = 2e-15
Identities = 147/743 (19%), Positives = 266/743 (35%), Gaps = 97/743 (13%)
Query: 898 YPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETS 957
Y K A K KS S+ GK K K+++ +SE LE
Sbjct: 727 YDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKE 786
Query: 958 RKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGD 1017
KS G + P+ D DE + + ++ K + + D
Sbjct: 787 IKSMSKIGAARTTKKRI---PNTKDFDSSEDEKHSKKGMD----NQGHKNLKTSQEGSSD 839
Query: 1018 KTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSS 1077
+RK + S E V E R+R P+ + + + K + S +
Sbjct: 840 DAERKQERETFSSAEGTVDKDTTIMEL----RDRLPKKQQA-SASTDGVDKLSGKEQSFT 894
Query: 1078 SQKDEKITGTPRKAH---SKSAKEHQE-TKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKP 1133
S + K+ T K+ +K+ K+ Q+ + E+ +KKD S + + K++ K
Sbjct: 895 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD---KKQSKKGT 951
Query: 1134 NEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDR 1193
EK KP D K + K +++ +ESSS KL E + PK + D
Sbjct: 952 EEKKKPSDFKKKVIK-------MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1004
Query: 1194 TPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRR 1253
+ KI KK +L+ K G ++ ++++ K + + K+ K+ GK R
Sbjct: 1005 EKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSR 1064
Query: 1254 KVTGTEGSSSTLVDYT---------------------------------------STSST 1274
K + SSS Y+ S +
Sbjct: 1065 K--RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEE 1122
Query: 1275 GGSPVRKSEEKTDTKRTVIKTMEEYNND-NTAPAEDVIIMIQVPQSKWDKDDFESEEEDV 1333
+K +++T +K+ + E+ N T+ + S + DD S E
Sbjct: 1123 SSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGS 1182
Query: 1334 KSTQPISSVGK-----------PASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH 1382
Q I V + +S + +S V + +++P +I K +
Sbjct: 1183 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRI---AKKMLL 1239
Query: 1383 EIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENP--EKRKNSTQPEKESNLD-------- 1432
E I+ + S ++ +S ++ + + +ENP E+ KN E +S+ +
Sbjct: 1240 EEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1299
Query: 1433 -RLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEK 1491
RL S +S +E +T K N+ + D + D D +E S+ E
Sbjct: 1300 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSE-DSDFQESGVSEEVSES 1358
Query: 1492 NELTRRKDSPSRNKDSASGQ---KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKAT 1548
+ R + ++ + Q K K + R ++ + KSNS + K + +
Sbjct: 1359 EDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEE 1418
Query: 1549 YDTKRPNEETKSVDKNPCKDREK 1571
+ + E+ K+P K R+K
Sbjct: 1419 EEEEEEEEDENDDSKSPGKGRKK 1441
Score = 73.6 bits (179), Expect = 2e-12
Identities = 170/933 (18%), Positives = 346/933 (37%), Gaps = 162/933 (17%)
Query: 998 FKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPR--- 1054
F+++ + ++ + K K +K+ + + ++ + G ++K+D S
Sbjct: 246 FENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSY 305
Query: 1055 -----SEPPIKKAKEETPKTDNTKSS-----SSSQKDEKITGTPRKAHSKSAKEHQETKP 1104
+ IKKAK+ T N SS + + +I+ + K+ K
Sbjct: 306 SALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIK 365
Query: 1105 VKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV--DKDFES 1162
+++D + + ++ KE+ K+ +K +D K E + RK E+ KD
Sbjct: 366 KAHLALEEDLNSEFRAMDAVNKEKNTKE----HKVIDAKFETKARKGEKPCALEKKDISK 421
Query: 1163 SSMKISKLEV----------TEIVKPSPK---------RKMEPDTEKMDRTPEKDKISLS 1203
S K+S+ +V TE + + RK EP E + + + D +S
Sbjct: 422 SEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVS 481
Query: 1204 APA---KKIKLNRETGKKIGST-----ENISNTKEPSEKLE---STSSKVKQEKVKGKVR 1252
P+ + I N ET ++ S+ + S T++ E + SSK + +K K
Sbjct: 482 VPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTT 541
Query: 1253 RKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKT------MEEYNNDNTAP 1306
KVT T V +++ G ++K K + + + N+DN
Sbjct: 542 AKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHL 601
Query: 1307 AEDVIIMIQVPQSKWDKDDFESEEEDVK-----STQPISSVGKPASVIKNVSTKPSNIVK 1361
E+ + ++ EE D++ T P+ + V N + + VK
Sbjct: 602 VENEVSLLL-------------EESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVK 648
Query: 1362 YPEKESEPSEKIQKFTKDVSHEIIQH----EVKSSKNSASSEKGKTKDRDYSVLEKENPE 1417
+K S P K K ++ S I + ++ SK S + ++ D ++L++ +
Sbjct: 649 EKQKLSVPVRKKDK--RNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS-- 704
Query: 1418 KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKK--- 1474
+ +S+ + + N N + + +Q+ K+ + K S+ + S+ D + K
Sbjct: 705 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSI 764
Query: 1475 -------TDYDTREYSSSKRRDEKN-------ELTRRK-------DSPSRNKDSASGQKN 1513
T ++ Y S ++ K+ T+++ DS K S G N
Sbjct: 765 ISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDN 824
Query: 1514 KPREERDLPKKGTGDS------------------KKSNSSPSRDRKPHDHKATYDTKRPN 1555
+ + ++G+ D K + RDR P +A+ T +
Sbjct: 825 QGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVD 884
Query: 1556 E-----------ETKSVDKNPCKDREKHVLEARNNKESSG-----NKLLYILNPPETQ-- 1597
+ E + V + K++ KH+ K G K L ET
Sbjct: 885 KLSGKEQSFTSLEVRKVAET--KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSED 942
Query: 1598 --------VEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESN 1649
E+++ K +K + Q SS + L + F + + +
Sbjct: 943 DKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTT 1002
Query: 1650 VSVKEEESSGNISKDLKDKIVEKAKESL---DTAAVVQVGISRNQSHSSPSV-------S 1699
K+ + + + KD++ + A++S D+ + S+N ++ S
Sbjct: 1003 DGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKS 1062
Query: 1700 PSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1759
+ S S T +S S D + K+ + ++++ K++ K + + + E+
Sbjct: 1063 SRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEE 1122
Query: 1760 SQK-HKHKKKKSKKNKDKEKEKEKDDQKVKSVT 1791
S + +K KK+++ K KEK +++ T
Sbjct: 1123 SSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTST 1155
Score = 56.2 bits (134), Expect = 3e-07
Identities = 62/311 (19%), Positives = 123/311 (39%), Gaps = 16/311 (5%)
Query: 887 QSHRSRNIGSNYPEKLSARDGHNQKDNTKSKE------KESENAPGDGKGNKHKKHRKRR 940
QS + + P + D N +N +K+ K + ++ DG + + K+R
Sbjct: 1205 QSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKR 1264
Query: 941 KGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESIT--- 997
G+++E E + S + EE+K R T V D E T
Sbjct: 1265 TGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLT-VSDGESGEEKKTKPK 1323
Query: 998 -FKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVD-GERERSPRS 1055
K V +++R+ ++ + VS+ E+ +P +K + E +RS +
Sbjct: 1324 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1383
Query: 1056 EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYS 1115
+ ++ K + + KS+S +++EK + + +E + K +K
Sbjct: 1384 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR 1443
Query: 1116 KDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEI 1175
K +K +KL T+ + A K E+ + + E+ + K E +D + I+ T++
Sbjct: 1444 KILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPIT----TKL 1499
Query: 1176 VKPSPKRKMEP 1186
V + EP
Sbjct: 1500 VLDEDEETKEP 1510
Score = 55.8 bits (133), Expect = 4e-07
Identities = 116/641 (18%), Positives = 238/641 (37%), Gaps = 108/641 (16%)
Query: 902 LSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSR 961
L R K+ +K + ++ DG + +K K+ + +E+ + + + + +
Sbjct: 896 LEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKK 955
Query: 962 EPTGVE----------ENKTDSLFVLPSRDDAT-------PVRDEPMDAESITFKSVSEK 1004
+P+ + E+ +D LP R++ +++ D E + K + +K
Sbjct: 956 KPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKS-KKIRDK 1014
Query: 1005 DKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKE 1064
+++D+ +K+ K D S+ + A G ++K +S R +
Sbjct: 1015 TSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDT 1074
Query: 1065 E--TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEK 1122
E + K D SS K ++ + ++ KE Q + + + +K K ++
Sbjct: 1075 EKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNK--KKKQ 1132
Query: 1123 LTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKR 1182
T+ ++KA EK + KRK+ D E + E S ++
Sbjct: 1133 RTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQN----SIGE--GSSDEQ 1186
Query: 1183 KMEPDTEKM--------DRTPEKDKISLSAP----------------AKKIKLNRETGKK 1218
K++P TE + ++ + +S S P AKK+ L E
Sbjct: 1187 KIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL-EEIKAN 1245
Query: 1219 IGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSS----------TLVDY 1268
+ S E+ S+ EP E + T + ++ + + +V S S L+ +
Sbjct: 1246 LSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRH 1305
Query: 1269 TSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1328
T S G S K + + K + + +++++ ++ +S ++ ES
Sbjct: 1306 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD-------FQESGVSEEVSES 1358
Query: 1329 EEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHE 1388
E+E +P + K A + +N + Y +K+ K+Q E
Sbjct: 1359 EDEQ----RPRTRSAKKAELEENQRS-------YKQKKKRRRIKVQ-------------E 1394
Query: 1389 VKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSK 1448
SS+N ++SE E E+++ + E+E + +E + KS + K
Sbjct: 1395 DSSSENKSNSE--------------EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRK 1440
Query: 1449 EARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRD 1489
+ R K D R + +++ RE K R+
Sbjct: 1441 KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLRE 1481
Score = 34.3 bits (77), Expect = 1.1
Identities = 23/115 (20%), Positives = 49/115 (42%), Gaps = 6/115 (5%)
Query: 1404 KDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASS 1463
K D+ E E+ + + N D+++ G+ + ++SKE TS S + S
Sbjct: 17 KLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGS 76
Query: 1464 NKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREE 1518
+R K+ +Y S ++ T +D+ + N ++ ++ P+E+
Sbjct: 77 ------SRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKED 125
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 109 bits (273), Expect = 2e-23
Identities = 189/865 (21%), Positives = 349/865 (40%), Gaps = 109/865 (12%)
Query: 980 RDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAK 1039
R TP+R P + +T S E ++ ++K K K+ S+ S +N KP K
Sbjct: 658 RVKTTPLR-RPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDN-PKPNK 715
Query: 1040 GPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEH 1099
P+ K +++ S+ + KE + + S SS D I + H+ +
Sbjct: 716 LPKSKQSETVDQNSDSDEMLAILKEVS------RMSHSSSSDTDIN----EIHTNHKTLY 765
Query: 1100 Q-ETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDK 1158
+T+ K++K K+ TK+ K+ K + +K +KR+ ++E D
Sbjct: 766 DLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISK------KKRQTQSESSNYDS 819
Query: 1159 DFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK 1218
+ E +SK+ K K P+T+ D + E +K S + N +T ++
Sbjct: 820 ELEKEIKSMSKIGAARTTK-----KRIPNTKDFDSS-EDEKHSKKGMDNQGHKNLKTSQE 873
Query: 1219 IGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTL--VDYTS--TSST 1274
GS+++ + K+ E S V ++ ++R ++ + +S++ VD S S
Sbjct: 874 -GSSDD-AERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSF 931
Query: 1275 GGSPVRK-SEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDV 1333
VRK +E K +K KT ++ + + AE + K D+ D SE++
Sbjct: 932 TSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL--------KKDQSDETSEDDKK 983
Query: 1334 KSTQPISSVGKPASVIKNV-------STKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ 1386
+S + KP+ K V + K PE+E K K + +
Sbjct: 984 QSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH--FPKGIKQIKNGTTD 1041
Query: 1387 HEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK-NSTQPEKESNLDRLNEQGNFKSLSQ 1445
E KS K + K K + DY+ EK + +S++ +K N E+ K L +
Sbjct: 1042 GEKKSKKIRDKTSKKKDELSDYA--EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGK 1099
Query: 1446 SSKEARTSDKHDSTRASSNKDFTPNRDKKT---DYDTREYSSSKRRDEKNELTRRKDSPS 1502
SS++ + D+ + S +D + DK+ + R SSKR T+ S S
Sbjct: 1100 SSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRN------TKEIQSGS 1153
Query: 1503 RNKDSA-SGQKNKPREERDLPKKGT---GDSKKSNSSPSRDRKPHDHKATYDTKRPNEET 1558
+ D+ S + NK +++R KK + K+++ S RK D ++ + +++
Sbjct: 1154 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1213
Query: 1559 KSVDKNPCKDR------EKHVLEARNNK-ESSGNKLLYIL-----------NPPETQVEK 1600
S+ + ++ E VL + +SSG++ L N PE ++ K
Sbjct: 1214 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1273
Query: 1601 EQITGQI-------DKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
+ + +I + + +P+ + DE A +ESDS+S S K
Sbjct: 1274 KMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKK 1333
Query: 1654 EEE-----------SSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSR 1702
S G ++ K K E + V S + VS
Sbjct: 1334 PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEV 1393
Query: 1703 SHSPSGSQTRSHSSS-ASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQ 1761
S S + R+ S+ A E+Q S K+KKK+ + K ++ + E+ +
Sbjct: 1394 SESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS-------EEEE 1446
Query: 1762 KHKHKKKKSKKNKDKEKEKEKDDQK 1786
+ K ++++ ++ +++E+E E DD K
Sbjct: 1447 EEKEEEEEEEEEEEEEEEDENDDSK 1471
Score = 93.2 bits (230), Expect = 2e-18
Identities = 177/925 (19%), Positives = 362/925 (39%), Gaps = 57/925 (6%)
Query: 901 KLSAR--DGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSR 958
KLS + D + N ++E+ + + G +K + + + L+ +++ S
Sbjct: 463 KLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIV--SV 520
Query: 959 KSREPTGVEENKTDSLFVLPSRD---DATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 1015
S P + EN ++ V S D D + ++ +++ S+ ++S KD R K K
Sbjct: 521 PSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKL-NISSKDNRGGIKSKTT 579
Query: 1016 GDKTKRKNDG-SAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDN--- 1071
TK + VS + +K A + D + +S P ++K +DN
Sbjct: 580 AKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHL 639
Query: 1072 TKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAK 1131
++ S +E + + + ET PV ++ + +KL+ K
Sbjct: 640 VENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 699
Query: 1132 KPNEKNKPLDN-KGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEK 1190
K N + +DN K K + + + VD++ +S M EV+ + S + D +
Sbjct: 700 KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRM---SHSSSSDTDINE 756
Query: 1191 MDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGK 1250
+ T K L A K + K S + K S K S K +Q + +
Sbjct: 757 I-HTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 815
Query: 1251 VRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDV 1310
E S + + T+ P K + ++ ++ K M+ + N +++
Sbjct: 816 NYDSELEKEIKSMSKIGAARTTKKR-IPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEG 874
Query: 1311 IIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKE-SEP 1369
+ K +++ F S E V I + + S + K KE S
Sbjct: 875 --SSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 932
Query: 1370 SEKIQKF--TKDVSHEIIQHEVKSSKNSAS--SEKGKTKDRDYSVLEKENPEKRKNSTQP 1425
S +++K TK+ S + K ++ S +EK KD+ E + + +K + +
Sbjct: 933 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK 992
Query: 1426 EKESNLDR--LNEQGNFKSLSQSSKEARTSDK--HDSTRASSNKDFTPNRDKKTDYDTRE 1481
+K S+ + + + ++S S +++ ++ H K+ T + +KK+ R+
Sbjct: 993 KKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSK-KIRD 1051
Query: 1482 YSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKP----REERDLPKKGTGDSKKSNSSPS 1537
+SK++DE ++ + + DS+ +K+K RE++ G K+ + S S
Sbjct: 1052 -KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSS 1110
Query: 1538 RDRKPHDHKATYDTKRP--NEETKSVDKNPCKDREKHVLEARNNKE-SSGNKLLYILNPP 1594
K Y K N K + + ++R +++ RN KE SG+
Sbjct: 1111 DTEK-------YSMKEDGCNSSDKRLKRIELRER-RNLSSKRNTKEIQSGSSSSDAEESS 1162
Query: 1595 ETQVEKEQITGQIDKST-VKPKPQLS---HSSRLSSDLTRETDEAAFEPDYNESDSESNV 1650
E +K+Q T K+ VK K + S + R +D+T + + D N S+
Sbjct: 1163 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1222
Query: 1651 SVKEEESSGNISKDLKDKIVEKA-KESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGS 1709
K + + N+ + + E+L + V V + + ++ +
Sbjct: 1223 EQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1282
Query: 1710 QTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKK 1769
S +S E ++ KK+ K+ ++ + + + ++ E K +++H+ +
Sbjct: 1283 NLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR 1342
Query: 1770 SK------KNKDKEKEKEKDDQKVK 1788
K ++ +++K K K+ ++VK
Sbjct: 1343 HKLTVSDGESGEEKKTKPKEHKEVK 1367
Score = 83.6 bits (205), Expect = 2e-15
Identities = 147/743 (19%), Positives = 266/743 (35%), Gaps = 97/743 (13%)
Query: 898 YPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETS 957
Y K A K KS S+ GK K K+++ +SE LE
Sbjct: 765 YDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKE 824
Query: 958 RKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGD 1017
KS G + P+ D DE + + ++ K + + D
Sbjct: 825 IKSMSKIGAARTTKKRI---PNTKDFDSSEDEKHSKKGMD----NQGHKNLKTSQEGSSD 877
Query: 1018 KTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSS 1077
+RK + S E V E R+R P+ + + + K + S +
Sbjct: 878 DAERKQERETFSSAEGTVDKDTTIMEL----RDRLPKKQQA-SASTDGVDKLSGKEQSFT 932
Query: 1078 SQKDEKITGTPRKAH---SKSAKEHQE-TKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKP 1133
S + K+ T K+ +K+ K+ Q+ + E+ +KKD S + + K++ K
Sbjct: 933 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD---KKQSKKGT 989
Query: 1134 NEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDR 1193
EK KP D K + K +++ +ESSS KL E + PK + D
Sbjct: 990 EEKKKPSDFKKKVIK-------MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1042
Query: 1194 TPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRR 1253
+ KI KK +L+ K G ++ ++++ K + + K+ K+ GK R
Sbjct: 1043 EKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSR 1102
Query: 1254 KVTGTEGSSSTLVDYT---------------------------------------STSST 1274
K + SSS Y+ S +
Sbjct: 1103 K--RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEE 1160
Query: 1275 GGSPVRKSEEKTDTKRTVIKTMEEYNND-NTAPAEDVIIMIQVPQSKWDKDDFESEEEDV 1333
+K +++T +K+ + E+ N T+ + S + DD S E
Sbjct: 1161 SSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGS 1220
Query: 1334 KSTQPISSVGK-----------PASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH 1382
Q I V + +S + +S V + +++P +I K +
Sbjct: 1221 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRI---AKKMLL 1277
Query: 1383 EIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENP--EKRKNSTQPEKESNLD-------- 1432
E I+ + S ++ +S ++ + + +ENP E+ KN E +S+ +
Sbjct: 1278 EEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1337
Query: 1433 -RLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEK 1491
RL S +S +E +T K N+ + D + D D +E S+ E
Sbjct: 1338 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSE-DSDFQESGVSEEVSES 1396
Query: 1492 NELTRRKDSPSRNKDSASGQ---KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKAT 1548
+ R + ++ + Q K K + R ++ + KSNS + K + +
Sbjct: 1397 EDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEE 1456
Query: 1549 YDTKRPNEETKSVDKNPCKDREK 1571
+ + E+ K+P K R+K
Sbjct: 1457 EEEEEEEEDENDDSKSPGKGRKK 1479
Score = 73.6 bits (179), Expect = 2e-12
Identities = 170/933 (18%), Positives = 346/933 (37%), Gaps = 162/933 (17%)
Query: 998 FKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPR--- 1054
F+++ + ++ + K K +K+ + + ++ + G ++K+D S
Sbjct: 284 FENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSY 343
Query: 1055 -----SEPPIKKAKEETPKTDNTKSS-----SSSQKDEKITGTPRKAHSKSAKEHQETKP 1104
+ IKKAK+ T N SS + + +I+ + K+ K
Sbjct: 344 SALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIK 403
Query: 1105 VKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV--DKDFES 1162
+++D + + ++ KE+ K+ +K +D K E + RK E+ KD
Sbjct: 404 KAHLALEEDLNSEFRAMDAVNKEKNTKE----HKVIDAKFETKARKGEKPCALEKKDISK 459
Query: 1163 SSMKISKLEV----------TEIVKPSPK---------RKMEPDTEKMDRTPEKDKISLS 1203
S K+S+ +V TE + + RK EP E + + + D +S
Sbjct: 460 SEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVS 519
Query: 1204 APA---KKIKLNRETGKKIGST-----ENISNTKEPSEKLE---STSSKVKQEKVKGKVR 1252
P+ + I N ET ++ S+ + S T++ E + SSK + +K K
Sbjct: 520 VPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTT 579
Query: 1253 RKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKT------MEEYNNDNTAP 1306
KVT T V +++ G ++K K + + + N+DN
Sbjct: 580 AKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHL 639
Query: 1307 AEDVIIMIQVPQSKWDKDDFESEEEDVK-----STQPISSVGKPASVIKNVSTKPSNIVK 1361
E+ + ++ EE D++ T P+ + V N + + VK
Sbjct: 640 VENEVSLLL-------------EESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVK 686
Query: 1362 YPEKESEPSEKIQKFTKDVSHEIIQH----EVKSSKNSASSEKGKTKDRDYSVLEKENPE 1417
+K S P K K ++ S I + ++ SK S + ++ D ++L++ +
Sbjct: 687 EKQKLSVPVRKKDK--RNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS-- 742
Query: 1418 KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKK--- 1474
+ +S+ + + N N + + +Q+ K+ + K S+ + S+ D + K
Sbjct: 743 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSI 802
Query: 1475 -------TDYDTREYSSSKRRDEKN-------ELTRRK-------DSPSRNKDSASGQKN 1513
T ++ Y S ++ K+ T+++ DS K S G N
Sbjct: 803 ISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDN 862
Query: 1514 KPREERDLPKKGTGDS------------------KKSNSSPSRDRKPHDHKATYDTKRPN 1555
+ + ++G+ D K + RDR P +A+ T +
Sbjct: 863 QGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVD 922
Query: 1556 E-----------ETKSVDKNPCKDREKHVLEARNNKESSG-----NKLLYILNPPETQ-- 1597
+ E + V + K++ KH+ K G K L ET
Sbjct: 923 KLSGKEQSFTSLEVRKVAET--KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSED 980
Query: 1598 --------VEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESN 1649
E+++ K +K + Q SS + L + F + + +
Sbjct: 981 DKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTT 1040
Query: 1650 VSVKEEESSGNISKDLKDKIVEKAKESL---DTAAVVQVGISRNQSHSSPSV-------S 1699
K+ + + + KD++ + A++S D+ + S+N ++ S
Sbjct: 1041 DGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKS 1100
Query: 1700 PSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1759
+ S S T +S S D + K+ + ++++ K++ K + + + E+
Sbjct: 1101 SRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEE 1160
Query: 1760 SQK-HKHKKKKSKKNKDKEKEKEKDDQKVKSVT 1791
S + +K KK+++ K KEK +++ T
Sbjct: 1161 SSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTST 1193
Score = 56.2 bits (134), Expect = 3e-07
Identities = 62/311 (19%), Positives = 123/311 (39%), Gaps = 16/311 (5%)
Query: 887 QSHRSRNIGSNYPEKLSARDGHNQKDNTKSKE------KESENAPGDGKGNKHKKHRKRR 940
QS + + P + D N +N +K+ K + ++ DG + + K+R
Sbjct: 1243 QSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKR 1302
Query: 941 KGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESIT--- 997
G+++E E + S + EE+K R T V D E T
Sbjct: 1303 TGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLT-VSDGESGEEKKTKPK 1361
Query: 998 -FKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVD-GERERSPRS 1055
K V +++R+ ++ + VS+ E+ +P +K + E +RS +
Sbjct: 1362 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1421
Query: 1056 EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYS 1115
+ ++ K + + KS+S +++EK + + +E + K +K
Sbjct: 1422 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR 1481
Query: 1116 KDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEI 1175
K +K +KL T+ + A K E+ + + E+ + K E +D + I+ T++
Sbjct: 1482 KILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPIT----TKL 1537
Query: 1176 VKPSPKRKMEP 1186
V + EP
Sbjct: 1538 VLDEDEETKEP 1548
Score = 55.8 bits (133), Expect = 4e-07
Identities = 116/641 (18%), Positives = 238/641 (37%), Gaps = 108/641 (16%)
Query: 902 LSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSR 961
L R K+ +K + ++ DG + +K K+ + +E+ + + + + +
Sbjct: 934 LEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKK 993
Query: 962 EPTGVE----------ENKTDSLFVLPSRDDAT-------PVRDEPMDAESITFKSVSEK 1004
+P+ + E+ +D LP R++ +++ D E + K + +K
Sbjct: 994 KPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKS-KKIRDK 1052
Query: 1005 DKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKE 1064
+++D+ +K+ K D S+ + A G ++K +S R +
Sbjct: 1053 TSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDT 1112
Query: 1065 E--TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEK 1122
E + K D SS K ++ + ++ KE Q + + + +K K ++
Sbjct: 1113 EKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNK--KKKQ 1170
Query: 1123 LTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKR 1182
T+ ++KA EK + KRK+ D E + E S ++
Sbjct: 1171 RTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQN----SIGE--GSSDEQ 1224
Query: 1183 KMEPDTEKM--------DRTPEKDKISLSAP----------------AKKIKLNRETGKK 1218
K++P TE + ++ + +S S P AKK+ L E
Sbjct: 1225 KIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL-EEIKAN 1283
Query: 1219 IGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSS----------TLVDY 1268
+ S E+ S+ EP E + T + ++ + + +V S S L+ +
Sbjct: 1284 LSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRH 1343
Query: 1269 TSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1328
T S G S K + + K + + +++++ ++ +S ++ ES
Sbjct: 1344 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD-------FQESGVSEEVSES 1396
Query: 1329 EEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHE 1388
E+E +P + K A + +N + Y +K+ K+Q E
Sbjct: 1397 EDEQ----RPRTRSAKKAELEENQRS-------YKQKKKRRRIKVQ-------------E 1432
Query: 1389 VKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSK 1448
SS+N ++SE E E+++ + E+E + +E + KS + K
Sbjct: 1433 DSSSENKSNSE--------------EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRK 1478
Query: 1449 EARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRD 1489
+ R K D R + +++ RE K R+
Sbjct: 1479 KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLRE 1519
Score = 32.3 bits (72), Expect = 4.2
Identities = 34/151 (22%), Positives = 64/151 (42%), Gaps = 13/151 (8%)
Query: 1484 SSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPH 1543
SS+ +E + R + + +K S SG + E ++GT S+KS SS S K
Sbjct: 25 SSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSK--EEGTSSSEKSKSSGSSRSK-- 80
Query: 1544 DHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQI 1603
++P+ TK V+ + K + + + E+S N + P T + + +
Sbjct: 81 --------RKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEP 132
Query: 1604 TGQIDKSTVKPKPQLSHSSRLSSDLTRETDE 1634
DK K P+ S++ ++ ++ E
Sbjct: 133 VLNEDKDDFK-GPEFRSRSKMKTENLKKRGE 162
Score = 31.6 bits (70), Expect = 7.2
Identities = 22/113 (19%), Positives = 47/113 (41%), Gaps = 6/113 (5%)
Query: 1404 KDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASS 1463
K D+ E E+ + + N D+++ G+ + ++SKE TS S + S
Sbjct: 17 KLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGS 76
Query: 1464 NKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPR 1516
+R K+ +Y S ++ T +D+ + N ++ ++ P+
Sbjct: 77 ------SRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPK 123
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 105 bits (261), Expect = 5e-22
Identities = 173/777 (22%), Positives = 301/777 (38%), Gaps = 109/777 (14%)
Query: 1028 VSKKENIVK-PAKGPQEKVDGERERSPRSEP--PIKKAKEETPKTDNTKSSSSSQKDEKI 1084
+S +ENI P+ + K + ++R E +KK E+ K D + SS +K E+
Sbjct: 110 LSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRER- 168
Query: 1085 TGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKG 1144
+ +PR+ S+S + + PV+ E+ K+ +S+ + + A + EK L
Sbjct: 169 SRSPRRRKSRSPSPRRRSSPVRRER-KRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPS 227
Query: 1145 EKRKRKTEEKGVDKDFESSSMKISKLE-VTEIVKPSPKRKMEPDTEKMDRTPEKDKISLS 1203
K K + ++ S +K+ K E + E +PSP++ + + EK P S S
Sbjct: 228 VKVKEPSVQEATST---SDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKS 284
Query: 1204 ---------APAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRK 1254
+ + + +R + S + PS + + ++ + R
Sbjct: 285 RSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSP 344
Query: 1255 VTGTEGSSSTLVDYTSTSSTGGS-------PVRKSEEKTDTKRTVIKTMEEYNNDNTAPA 1307
V SS++L +S+SS+ S P R S T+R +P
Sbjct: 345 VRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPP 404
Query: 1308 EDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS-VIKNVSTK----PSNIVKY 1362
P K + + ++ S G+ + V K+ T+ PS K
Sbjct: 405 A-------TPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKP 457
Query: 1363 PEKESEPSEKIQKFTKDVSHEIIQH--EVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK 1420
+ E SE+ K K + + +Q + + +SS+ G + S E E P++
Sbjct: 458 RKVELSESEE-DKGGKMAAADSVQQRRQYRRQNQQSSSDSGSS-----SSSEDERPKRSH 511
Query: 1421 NSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTR 1480
K + R +S S S ++ + K S R + +P ++ +
Sbjct: 512 -----VKNGEVGRRRRHSPSRSASPSPRKRQ---KETSPRGRRRRSPSPPPTRRRRSPSP 563
Query: 1481 EYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDL-----PKKGTGDSK---KS 1532
+RR RR SP + S S ++ P +R PK+ T K
Sbjct: 564 APPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKR 623
Query: 1533 NSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILN 1592
+SPS P + + P + + V K R L +++ K SS ++
Sbjct: 624 RASPS----PPPKRRVSHSPPPKQRSSPVTK-----RRSPSLSSKHRKGSSPSRSTREAR 674
Query: 1593 PPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSV 1652
P+ + + P+P+ +S + R A+ P +S S S +
Sbjct: 675 SPQPN----------KRHSPSPRPRAPQTSSSPPPVRRG---ASSSPQRRQSPSPSTRPI 721
Query: 1653 KEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSV--------SPSRSH 1704
+ +S+ + K ++KA S +V +V SR+ S S SP +S
Sbjct: 722 RR------VSRTPEPKKIKKAA-SPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQ 774
Query: 1705 SPSGS--------QTRSHSSSASSAESQDSK---KKKKKKEKKKHKKHKKHKKHKKH 1750
SPS + + +S + S S + D + KKKKKK+ KKHKK KKHKKHKKH
Sbjct: 775 SPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKH 831
Score = 92.4 bits (228), Expect = 3e-18
Identities = 163/754 (21%), Positives = 267/754 (35%), Gaps = 144/754 (19%)
Query: 636 LSREEFYREQRRLKEEE-KKKSKLDEFTNDFAKELMEYKKIQKER----RRSFSRSKSPY 690
L +EE +QR++++E+ K DE + KE E + ++ER RR SRS SP
Sbjct: 126 LKKEEI--KQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPR 183
Query: 691 SGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSP------------------- 731
SS R S SRS R++S S S + P
Sbjct: 184 RRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSD 243
Query: 732 ---------------PYPRRGRGKSRNY-----RSRSRSHGYHRSRSRSP----PYRRYH 767
P P + K + RSRSRS R+RSRSP P RR+
Sbjct: 244 ILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHR 303
Query: 768 SRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERY 827
SRSRS R SP +R P+ T R +PPP R R P + R
Sbjct: 304 SRSRSYSPRRRPSPRRRPSPRRRTPP------RRMPPP-------PRHRRSRSPVRRRRR 350
Query: 828 REWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQ 887
+G+ S++R P++ P +SP + RR
Sbjct: 351 S--------------SASLSGSSSSSSSSRSRSPPKK--PPKRTSSPPRKTRRLSPSASP 394
Query: 888 SHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEG 947
R R + + ++++ +PG G K KH+ K E
Sbjct: 395 PRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSG-KVTKHKGTEKRESPSP 453
Query: 948 FLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKR 1007
P +E S EE+K + S R + + S + S S +D+R
Sbjct: 454 APKPRKVELSES-------EEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDER 506
Query: 1008 ERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETP 1067
+ G+ +R+ + S + K K + G R RSP S PP ++ + +P
Sbjct: 507 PKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPR--GRRRRSP-SPPPTRRRRSPSP 563
Query: 1068 ---------KTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKV-------- 1110
T + + S + + +PR+ + + + P K
Sbjct: 564 APPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKR 623
Query: 1111 --------KKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES 1162
K+ S ++ ++ K + P+ +K KG R T E + +
Sbjct: 624 RASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSK--HRKGSSPSRSTREARSPQPNKR 681
Query: 1163 SS---------MKISKLEVTEIVKPSPKRKMEPD-----TEKMDRTPEKDKISLSAPAKK 1208
S S V SP+R+ P ++ RTPE KI +A
Sbjct: 682 HSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASP-- 739
Query: 1209 IKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDY 1268
+ ++ +++ S+ ++S + EP+ K K V+ + T S + V
Sbjct: 740 ---SPQSVRRVSSSRSVSGSPEPAAK--------KPPAPPSPVQSQSPSTNWSPAVPVKK 788
Query: 1269 TSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND 1302
+ + SP R S+++ K+ K +++ D
Sbjct: 789 AKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKD 822
Score = 67.0 bits (162), Expect = 2e-10
Identities = 138/602 (22%), Positives = 197/602 (32%), Gaps = 108/602 (17%)
Query: 517 PPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPP 576
PP R RS R R S + S +P PP PP T L P
Sbjct: 333 PPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPP--KKPPKRTSSPPRKTRRLSP 390
Query: 577 GVPPPQFSPQ-FPPGQPPPAGYSVPPP--GFPPAPANLS-TPWVSSGVQTAHSNTIPTTQ 632
PP+ + PP PPP P P + +S +P +SG T H T
Sbjct: 391 SASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRES 450
Query: 633 APPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSG 692
P + +K +L E D ++ +Q+ RR + R S
Sbjct: 451 PSPAPKP--------------RKVELSESEEDKGGKMAAADSVQQ--RRQYRRQNQQSSS 494
Query: 693 SSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHG 752
S S SS + + ++ R S SRS S SP R R K + R R R
Sbjct: 495 DSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSP----RKRQKETSPRGRRR--- 547
Query: 753 YHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYY 812
RS SPP R R RSP P +R P R PPP
Sbjct: 548 ----RSPSPPPTR---RRRSPSP--APPPRRRRTPTPPPRRR-----TPSPPPRR----- 588
Query: 813 GRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRN 872
R P + +R+Y P P R SP P R
Sbjct: 589 ------RSPSPRRYSPPIQRRY---------------SPSPPPKRRTASPPP--PPKRRA 625
Query: 873 SPFTRG-RREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGN 931
SP RR + RS + LS++ ++K ++ S+ +P K
Sbjct: 626 SPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSK---HRKGSSPSRSTREARSPQPNK-- 680
Query: 932 KHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPM 991
+H + R + S P V + S P R +
Sbjct: 681 RHSPSPRPRAPQTSSS---------------PPPVRRGASSS-----------PQRRQSP 714
Query: 992 DAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERER 1051
+ + VS + ++ K A + S+ S + AK P + +
Sbjct: 715 SPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQ 774
Query: 1052 SPRSE----PPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKE 1107
SP + P+KKAK TP ++S +K K H K K+H++ K K+
Sbjct: 775 SPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKD-KKHKKHKKHKK 833
Query: 1108 EK 1109
EK
Sbjct: 834 EK 835
Score = 55.1 bits (131), Expect = 6e-07
Identities = 141/616 (22%), Positives = 206/616 (33%), Gaps = 75/616 (12%)
Query: 490 PVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPS 549
PVR R G S+ SPP++ + S R R + +R PS
Sbjct: 344 PVR-RRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPS 402
Query: 550 LPATPVFVPVPPPPLYPPPP----HTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFP 605
PATP PP + P P T V P + S + + S P P
Sbjct: 403 PPATP-----PPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRES-PSPAPK 456
Query: 606 PAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDF 665
P LS G + A ++++ + YR Q + + S E
Sbjct: 457 PRKVELSESEEDKGGKMAAADSV--------QQRRQYRRQNQQSSSDSGSSSSSEDERP- 507
Query: 666 AKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSR 725
+ ++ ++ + RR S SRS SP +S + RS S RS S +
Sbjct: 508 KRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPP 567
Query: 726 SYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQ---AFRGQSPN 782
R+P P R R S R RS S R SPP +R +S S P+ A P
Sbjct: 568 RRRRTPTPPPRRRTPSPPPRRRSPS-----PRRYSPPIQRRYSPSPPPKRRTASPPPPPK 622
Query: 783 KRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYY 842
+R P +R R PPP + P K R K+R+
Sbjct: 623 RRASPSPPPKR----RVSHSPPPKQRSS----------PVTKRRSPSLSSKHRK------ 662
Query: 843 KGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKL 902
G+ P S RE SP+ N R+SP R R R S+ P++
Sbjct: 663 -----GSSPSRS-TREARSPQP----NKRHSPSPRPRAPQ-TSSSPPPVRRGASSSPQRR 711
Query: 903 SARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSRE 962
+ + S+ E + K RR +PE ++K
Sbjct: 712 QSPSPSTRPIRRVSRTPEPKKIK---KAASPSPQSVRRVSSSRSVSGSPE--PAAKKPPA 766
Query: 963 PTGVEENKTDSLFVLPS-----RDDATPVRDEP--MDAESITFKSVSEKDKRERDKPKAK 1015
P ++++ S P+ TP P D E K +KDK+ + K K
Sbjct: 767 PPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHK 826
Query: 1016 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSS 1075
K +K A + + A + E EP K + E+ DN
Sbjct: 827 KHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEP---KKETESEAEDNLDDL 883
Query: 1076 SSSQKDEKITGTPRKA 1091
+ EK + RKA
Sbjct: 884 EKHLR-EKALRSMRKA 898
Score = 51.2 bits (121), Expect = 9e-06
Identities = 142/687 (20%), Positives = 223/687 (32%), Gaps = 129/687 (18%)
Query: 602 PGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEF 661
P P + P V T+ +P + P +E E+ KE+EK+K++
Sbjct: 221 PELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPS-PEKNSKKEKEKEKTR---- 275
Query: 662 TNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTY-SKSRSGSTRSRSYSRSFS 720
+ R RS SRS++ S++R + S+SRS S R R R
Sbjct: 276 --------------PRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRP 321
Query: 721 RSHSRSYSRS-PPYPRRGRGKSRNYRSR-------SRSHGYHRSRSRSPPYRRYHSRSRS 772
R+ R PP PR R +S R R S SRSRSPP + S
Sbjct: 322 SPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSP 381
Query: 773 PQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWER 832
P+ R SP+ R + PPP K + + + K R
Sbjct: 382 PRKTRRLSPSA-----SPPRRRHRPSPPATPPP---KTRHSPTPQQSNRTRKSRVSVSPG 433
Query: 833 KYREWYEKYYKGYAAGAQPRPSANR---ENFSPERFLPLNIRNSPFTRGRREDYVGGQSH 889
+ K+ KG P P+ E E + + + RR+ Q
Sbjct: 434 RTSGKVTKH-KGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQS 492
Query: 890 RSRNIGSNYPEKLSARDGHNQKDNTKSKEKESEN---APGDGKGNKHKKHRKRRKGEES- 945
S + S+ E + H + + + S + +P K K R RR+ S
Sbjct: 493 SSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSP 552
Query: 946 ---EGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFK--- 999
+P R+ R PT +T S P R +P R P +
Sbjct: 553 PPTRRRRSPSPAPPPRRRRTPTPPPRRRTPS--PPPRRRSPSPRRYSPPIQRRYSPSPPP 610
Query: 1000 ---------------SVSEKDKRE---RDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGP 1041
S S KR PK + ++ S SK P++
Sbjct: 611 KRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRST 670
Query: 1042 QEKVDGE---------RERSPR---SEPPIKKAKEE--------------------TPKT 1069
+E + R R+P+ S PP+++ TP+
Sbjct: 671 REARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEP 730
Query: 1070 DNTKSSSSS--------QKDEKITGTPRKAHSK-----SAKEHQETK-------PVKEEK 1109
K ++S ++G+P A K S + Q PVK+ K
Sbjct: 731 KKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAK 790
Query: 1110 VKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISK 1169
++ +K KK +K D K +K K+ +EK V ++ +
Sbjct: 791 SPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAI 850
Query: 1170 LEVT-------EIVKPSPKRKMEPDTE 1189
T + P PK++ E + E
Sbjct: 851 AAATTTLAQEEPVAAPEPKKETESEAE 877
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 104 bits (260), Expect = 7e-22
Identities = 192/937 (20%), Positives = 351/937 (37%), Gaps = 156/937 (16%)
Query: 900 EKLSARDGHNQKDNTKSKEKESENAPG----DGKGNKHKKHRKRRKGEESEGFLNPELLE 955
++ SA + N K+ E+ S+ P D +K + E+S E LE
Sbjct: 213 QEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLE 272
Query: 956 TSRKSRE----PTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDK 1011
T+ KS E P VEE K + + + + K V ++ +++K
Sbjct: 273 TAPKSEEFSDLPCPVEEIKNYT---------------KEHNNLILLNKDVQQESSEQKNK 317
Query: 1012 PKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDN 1071
KG+K N+ KKE K K E + + E K+AKE+ ++
Sbjct: 318 STDKGEKKPDSNE-KGERKKEKKEKTEKKFDHSKKSEDTQKVKDE---KQAKEKEVESLK 373
Query: 1072 TKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAK 1131
S +S K + + GT + + + + V ++ D+ S + T+EE
Sbjct: 374 LPSEKNSNKAKTVEGTKEDFSLIDS----DVDGLTDITVSSVHTSDLSSFEEDTEEEVVT 429
Query: 1132 KPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKM 1191
+ + + + E++ ++ + K D SS K + + KP K D++
Sbjct: 430 SDSMEEGEITSDDEEKNKQNKTKTQTSD--SSEGKTKSVRHAYVHKPYLYSKYYSDSDD- 486
Query: 1192 DRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKV 1251
+ T E+ + S++ ++ L R+ N ++ EK + + K K K KG+
Sbjct: 487 ELTVEQRRQSIAKEKEERLLRRQI-----------NREKLEEKRKQKAEKTKSSKTKGQG 535
Query: 1252 RRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVI 1311
R V E S+ +L E K + V+K E +
Sbjct: 536 RSSVDLEESSTKSL-----------------EPKAARIKEVLK-------------ERKV 565
Query: 1312 IMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKP----SNIVKYPEKES 1367
+ +V SK K D + EE+ K Q K K S +K+ +S
Sbjct: 566 LEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKS 625
Query: 1368 EPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEK 1427
EPS+ ++ ++ + H V +KN S LE+E+ KR+ ST
Sbjct: 626 EPSKPARRLSESL------HVVDENKNE-------------SKLEREH--KRRTSTPVIM 664
Query: 1428 ESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR 1487
E + E+ + + + + + + + + S+ K+ KK D +T S +
Sbjct: 665 EG----VQEETDTRDVKRQVERSEICTEEPQKQKSTLKN--EKHLKKDDSETPHLKSLLK 718
Query: 1488 RDEKN--ELTRRKDSPSRNKDSASGQ-----KNKPREERDL--PKKGTGDSKKSNSSPSR 1538
++ K+ E R+ +PS +K S + +K +E +L +KG + +
Sbjct: 719 KEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQ 778
Query: 1539 DRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQV 1598
+ D K +K NE SV K +++++ N NK L+ +T+
Sbjct: 779 TKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKA 838
Query: 1599 E---KEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKE- 1654
E + +I K ++ K R S + + + D + ++ +SN+ +E
Sbjct: 839 EHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSED------KCDMDSTNMDSNLKPEEV 892
Query: 1655 -EESSGNISKDLKDKIVEKAKESLDTAAV------VQVGISRNQSHSSPSVSPSRSHSPS 1707
+ L++K+V K+K V +Q G ++ + P + + S
Sbjct: 893 VHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDS 952
Query: 1708 GSQTRSH------------------SSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1749
Q +S SSSA S + S + K K+K+K K
Sbjct: 953 EKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDS----- 1007
Query: 1750 HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQK 1786
T +E + S HK + K K+K++ K D K
Sbjct: 1008 -TSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDK 1043
Score = 91.7 bits (226), Expect = 6e-18
Identities = 176/863 (20%), Positives = 324/863 (37%), Gaps = 122/863 (14%)
Query: 915 KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 974
+S KE E + N+ K KR++ E + +T + R +EE+ T SL
Sbjct: 495 QSIAKEKEERLLRRQINREKLEEKRKQKAEKT-----KSSKTKGQGRSSVDLEESSTKSL 549
Query: 975 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENI 1034
+R E + + K V+ KR++D ++ +K KE +
Sbjct: 550 EPKAARIK------EVLKERKVLEKKVALSKKRKKDSRNV--EENSKKKQQYEEDSKETL 601
Query: 1035 VKPAKGPQEKVDGERERS---PRSEP--PIKKAKEETPKTDNTKSSSSSQKDEKI-TGTP 1088
+EK+ +E +SEP P ++ E D K+ S +++ K T TP
Sbjct: 602 KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTP 661
Query: 1089 RKAHSKSAKEHQETKPVK----------------------EEKVKKDYSKDVKSEKLTTK 1126
+ +E +T+ VK E+ +KKD S+ + L K
Sbjct: 662 --VIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKK 719
Query: 1127 EEKA--KKPNEKNKPLDNK---GEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPK 1181
E K+ +KP + P ++K K K K D+ SS K K+E I K S +
Sbjct: 720 EVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVE-ENIQKQSQQ 778
Query: 1182 RKMEPDTEKMDRTPEKDKISLSAPAKK--------IKLNRETGKKIGSTE---NISNTKE 1230
K+ D + ++ +++ LS K IK + K+ E + TK
Sbjct: 779 TKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKA 838
Query: 1231 PSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKR 1290
+ S+ SK++++ + G + +T S S D ST K EE ++
Sbjct: 839 EHKSRRSSDSKIQKDSL-GSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEK 897
Query: 1291 TVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIK 1350
K++ E E +++ K + ++ V T+ K A+
Sbjct: 898 RRTKSLLE---------EKLVLK--------SKSKTQGKQVKVVETELQEGATKQAT--- 937
Query: 1351 NVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSV 1410
+ KP E +SE K + K ++ ++++ +SA S + + R
Sbjct: 938 --TPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLP 995
Query: 1411 LEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPN 1470
L KE + K+ST E +L++ +SL SSK+ + D+
Sbjct: 996 LAKEKYKSDKDSTSTRLER---KLSDGHKSRSLKHSSKDIKKKDE--------------- 1037
Query: 1471 RDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSK 1530
+K D D +E SS + N K R ++ G ++ + + S
Sbjct: 1038 -NKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLST 1096
Query: 1531 KSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYI 1590
S SS R +K D T P +E +D P + V + ++N+ ++ + +
Sbjct: 1097 PSGSSLQRPKKSGDM-----TLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDS 1151
Query: 1591 LNPPE---TQVEKEQI-TGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAF---EPDYNE 1643
N + V+K+++ T D P + + ++S+ + D + +
Sbjct: 1152 ENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQS 1211
Query: 1644 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1703
+ S+ N KE G ++ + V + L +A + +N +++ +
Sbjct: 1212 AVSKMNPGEKEPIHRGTTEVNIDSETVHR---MLLSAPSENDRVQKNLKNTA-----AEE 1263
Query: 1704 HSPSGSQTRSHSSSASSAESQDS 1726
H G T HS++ S+ S S
Sbjct: 1264 HVAQGDATLEHSTNLDSSPSLSS 1286
Score = 80.5 bits (197), Expect = 1e-14
Identities = 148/665 (22%), Positives = 244/665 (36%), Gaps = 102/665 (15%)
Query: 1186 PDTEKMDRTPEKDKISLSAPAKKI------------KLNRETGKKIGSTENISNTKEPSE 1233
PD EK D + + P+ + LN+E STE SN K
Sbjct: 174 PDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTET-SNAK---- 228
Query: 1234 KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYT-STSSTGGSPVR---KSEEKTDTK 1289
TS + ++ T E +S + D ST+ +GG + KSEE +D
Sbjct: 229 ----TSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLP 284
Query: 1290 RTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVI 1349
V EE N +++ V Q ES E+ KST KP S
Sbjct: 285 CPV----EEIKNYTKEHNNLILLNKDVQQ--------ESSEQKNKSTD--KGEKKPDSNE 330
Query: 1350 KNVSTKPSNIVKYPE----KESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKD 1405
K K + K+SE ++K++ + E+ ++ S KNS ++ +
Sbjct: 331 KGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTK 390
Query: 1406 RDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNK 1465
D+S+++ + + S+L E + ++ S E D + NK
Sbjct: 391 EDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNK 450
Query: 1466 DFTPNRDKKTD--------YDTREYSSSKR-RDEKNELT--RRKDSPSRNKDSASGQKNK 1514
T D Y + Y SK D +ELT +R+ S ++ K+ ++
Sbjct: 451 TKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQI 510
Query: 1515 PREERDLPKKGTGDSKKSNSSPSRDRKPHD-HKATYDTKRPN--------EETKSVDKNP 1565
RE+ + +K + KS+ + + R D +++ + P +E K ++K
Sbjct: 511 NREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKV 570
Query: 1566 CKDREKHVLEARNNKESSGNKLLYILNPPET-----QVEKEQITGQIDKSTVKPKPQLSH 1620
+ K ++RN +E+S K Y + ET EKE+I+ + V K + S
Sbjct: 571 ALSK-KRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSK 629
Query: 1621 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1680
+R S+ DE N S E E S + I+E +E DT
Sbjct: 630 PARRLSESLHVVDE------------NKNESKLEREHKRRTSTPV---IMEGVQEETDTR 674
Query: 1681 ----AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKK--- 1733
V + I + S + H H S E + SK+K +++
Sbjct: 675 DVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTP 734
Query: 1734 -EKKKHKKHKKHKKHKKHAGTEVELEKS----------QKHKHKKKKSKKNKDKEKEKEK 1782
E K KHK G E EL S QK + K S +K + K K +
Sbjct: 735 SEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHR 794
Query: 1783 DDQKV 1787
+++K+
Sbjct: 795 NERKL 799
Score = 66.2 bits (160), Expect = 3e-10
Identities = 77/359 (21%), Positives = 148/359 (41%), Gaps = 39/359 (10%)
Query: 868 LNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGD 927
LN+ NS F R + + +S+ I S + A GH+ + + K E+E + P
Sbjct: 2715 LNVENSGF---RTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPK- 2770
Query: 928 GKGNKHKKHRKRRKGEESEGFLNPELL----ETSRKS---REPTGVEENKTDSLFVLPSR 980
K K+H + E + NP++L ET+++ EP +E + L LP
Sbjct: 2771 ---RKRKQHYLSSEDEPDD---NPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKT 2824
Query: 981 DDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKEN---IVKP 1037
T S T + + EKD E + G+K ++ +D + S++E+ I+K
Sbjct: 2825 SSET---------NSTTSRVMEEKD--EYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
Query: 1038 AKGPQEKVDGERERSPRSEPPIKKA---KEETPKTDNTKSSSSSQKDEKITGTPRKAHSK 1094
+G K E + + E++P + K + + +++ ++ S
Sbjct: 2874 KRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISN 2933
Query: 1095 SAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK 1154
E + V+ K S V + +++ E+ ++ + + D K ++ + EE+
Sbjct: 2934 DDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEE 2993
Query: 1155 GVDKDFESSSMKISKLEVTEI---VKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIK 1210
D+ +++ ++ E + PS KRK E RT + ++ AP KK K
Sbjct: 2994 EEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGA-RTRGQQRVE-EAPVKKAK 3050
Score = 56.2 bits (134), Expect = 3e-07
Identities = 81/397 (20%), Positives = 158/397 (39%), Gaps = 61/397 (15%)
Query: 1344 KPASVIKNVSTKPSNIVKYPEKESEPSEK--IQKFTKDVSHEIIQHEVKSSKNSASSEKG 1401
+P V ++++ + S E SE K I KD + I H V++ E
Sbjct: 2707 EPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEE-- 2764
Query: 1402 KTKDRDYSVLEKENPEKRKN----STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHD 1457
E+ P++++ S++ E + N D L+ + + + ++ ++ HD
Sbjct: 2765 ----------ERHMPKRKRKQHYLSSEDEPDDNPDVLDSR-----IETAQRQCPETEPHD 2809
Query: 1458 STRASSNKDFT--PNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKP 1515
T+ +++D P +T+ T K +E T K P +N D K++
Sbjct: 2810 -TKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK--PEQNDDDTI--KSQE 2864
Query: 1516 REERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLE 1575
++ + K+ G +K + K D + + +V+++P + K +
Sbjct: 2865 EDQPIIIKRKRGRPRKYPVETTLKMK--------DDSKTDTGIVTVEQSPSSSKLKVMQT 2916
Query: 1576 ARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRL-SSDLTRETDE 1634
+NKE++ + I N +E+I + + KPK L+ S SS+ R+ +
Sbjct: 2917 DESNKETANLQERSISNDDG----EEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK 2972
Query: 1635 AAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHS 1694
+ +P ++ + ES+ +EEE E T + + R+++
Sbjct: 2973 SVSDPVEDKKEQESDEEEEEEE--------------EDEPSGATTRSTTRSEAQRSKTQL 3018
Query: 1695 SPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1731
SPS+ R SP G++TR E KK K+
Sbjct: 3019 SPSIKRKREVSPPGARTRGQ----QRVEEAPVKKAKR 3051
Score = 42.4 bits (98), Expect = 0.004
Identities = 62/337 (18%), Positives = 135/337 (40%), Gaps = 69/337 (20%)
Query: 1473 KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQ------KNKPREERDLPKKGT 1526
+ + + T E S+ ++ + RKD N ++ SG K EER +PK+
Sbjct: 2718 ENSGFRTNEEIHSESYNKGEISSGRKD----NAEAISGHSVEADPKEVEEEERHMPKR-- 2771
Query: 1527 GDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNK 1586
K+ S + +P D+ D++ + + C + E H + N+++
Sbjct: 2772 ---KRKQHYLSSEDEPDDNPDVLDSRIETAQRQ------CPETEPHDTKEENSRD----- 2817
Query: 1587 LLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDS 1646
+ P+T E T ++ ++ K + S SS+ T E +P+ N+ D+
Sbjct: 2818 ---LEELPKTSSETNSTTSRV----MEEKDEYS-----SSETTGE------KPEQNDDDT 2859
Query: 1647 ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSP 1706
+K +E I+ K K V+ + + + + SP
Sbjct: 2860 -----IKSQEED--------QPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSP 2906
Query: 1707 SGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK----KHKKHKKHKKHAGTEVELEKSQK 1762
S S+ + + S+ E+ + +++ + + K ++ +K K+ + E S+
Sbjct: 2907 SSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEP 2966
Query: 1763 HKHKKK--------KSKKNKDKEKEKEKDDQKVKSVT 1791
+ ++K K ++ D+E+E+E++D+ + T
Sbjct: 2967 ERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATT 3003
Score = 41.6 bits (96), Expect = 0.007
Identities = 66/331 (19%), Positives = 126/331 (38%), Gaps = 42/331 (12%)
Query: 1471 RDKKTDYDTRE-YSSSKRRDEK---NELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT 1526
RD D DT+ Y + ++R + N L SP NK+ + + + + G
Sbjct: 72 RDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGI 131
Query: 1527 G-------DSKKSNS-SPSRDRKPHDHKATYDTKRPNE-ETKSVDKNPCKDREKHVLEAR 1577
D K +++ P ++ H+ AT + K T D+ P +
Sbjct: 132 DRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTP 191
Query: 1578 NNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAF 1637
+ N + IL T + +E + T K S +L S T +T
Sbjct: 192 GPSANVANDAMSILETI-TSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTST--- 247
Query: 1638 EPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPS 1697
++ + +++ KE+ ++ + + L+ K++E D V+ + + H++
Sbjct: 248 ----DKERTSEDMADKEKSTADSGGEGLET--APKSEEFSDLPCPVEEIKNYTKEHNNLI 301
Query: 1698 VSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVEL 1757
+ + SS + + +KK EK + KK KK K KK
Sbjct: 302 LL--------NKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKF------- 346
Query: 1758 EKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
H K + ++K KD+++ KEK+ + +K
Sbjct: 347 ----DHSKKSEDTQKVKDEKQAKEKEVESLK 373
Score = 40.4 bits (93), Expect = 0.016
Identities = 66/294 (22%), Positives = 96/294 (32%), Gaps = 46/294 (15%)
Query: 1500 SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETK 1559
S +R S K R + LP + T D+ S D + K+T D+ ET
Sbjct: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE-KSTADSGGEGLETA 274
Query: 1560 SVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLS 1619
+ D V E +N + N L +LN Q EQ DK KP
Sbjct: 275 PKSEE-FSDLPCPVEEIKNYTKEHNN--LILLNKDVQQESSEQKNKSTDKGEKKP----- 326
Query: 1620 HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAK---ES 1676
S + +E E + + SE VK+E K K+K VE K E
Sbjct: 327 -DSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDE-------KQAKEKEVESLKLPSEK 378
Query: 1677 LDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKK 1736
A G + S V + S T SS E +
Sbjct: 379 NSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE------------ 426
Query: 1737 KHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1790
T +E+ + ++K+K+NK K + + + K KSV
Sbjct: 427 --------------VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
Score = 36.2 bits (82), Expect = 0.29
Identities = 20/39 (51%), Positives = 20/39 (51%), Gaps = 6/39 (15%)
Query: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAG 596
P PPPP PPPP P P PPP P PG P AG
Sbjct: 7 PQPPPPAPPPPP---PQPQPQPPP---PPPGPGAGPGAG 39
Score = 33.1 bits (74), Expect = 2.5
Identities = 20/46 (43%), Positives = 21/46 (45%), Gaps = 11/46 (23%)
Query: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPG 603
P P PP PPP PPPQ PQ PP PPP + P G
Sbjct: 5 PQPQPPPPAPPP---------PPPQPQPQPPP--PPPGPGAGPGAG 39
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 103 bits (258), Expect = 1e-21
Identities = 186/809 (22%), Positives = 318/809 (39%), Gaps = 126/809 (15%)
Query: 951 PELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERD 1010
P + +T K R + E+ + LPS+ ++E + + K + ++
Sbjct: 528 PVVKQTKLKQRADS--RESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVE-SKE 584
Query: 1011 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTD 1070
K K DK + +V++KE P+K V E ++ K AKE+T K +
Sbjct: 585 KVMVKKDKPIKTETKPSVTEKE---VPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKE 641
Query: 1071 NTKSSSSSQKDEKITGTPRKAHSKSAKE---HQETKPVKEEKVKKDYSKDVKSE--KLTT 1125
TK +K+EK P+K +K + +E KP KEE VKK+ K++K E K
Sbjct: 642 -TKVKPEDKKEEK--EKPKKEVAKKEDKTPIKKEEKPKKEE-VKKEVKKEIKKEEKKEPK 697
Query: 1126 KEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES--SSMKISKLEVTEIVKPSPKRK 1183
KE K + P ++ K K EK++ K EEK K+ + K S ++E KP+
Sbjct: 698 KEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPA---A 754
Query: 1184 MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVK 1243
++P K + + +KD ++ P +K K+K
Sbjct: 755 LKPKVPKKEESVKKDSVAAGKPKEK-------------------------------GKIK 783
Query: 1244 QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND- 1302
K +GK V G+ +T + + G ++ + +R+++ + E+ D
Sbjct: 784 VIKKEGKAAEAVAAAVGTGATT---AAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF 840
Query: 1303 NTAPAEDVIIMIQV-PQSKWDKDDFESEEEDVKSTQPISS--VGKPASVIKNVSTKPSNI 1359
AE+V + + PQ + +D EE +K T+P+ + + K V K + P
Sbjct: 841 EELKAEEVDVTKDIKPQLELIED-----EEKLKETEPVEAYVIQKEREVTKGPAESPDEG 895
Query: 1360 VKYPE---------KESEPSEK-----IQKFTK-----DVSHEIIQHEVKSSKNSA---- 1396
+ E +E EP EK I+KF + S E +E K+ A
Sbjct: 896 ITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE 955
Query: 1397 ----------SSEKGKTKDRDYSVLEKEN--PEKRKN--STQPEKESNLDRLNEQGNFKS 1442
+S+ T+D + + E + EKR++ S E ++D E+G
Sbjct: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKG---E 1012
Query: 1443 LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS 1502
QS +EA DK + R +++ P + + DY + E +P+
Sbjct: 1013 AEQSEEEADEEDKAEDAR---EEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPT 1069
Query: 1503 RNKDSASGQKNKPREERDLPKKGTGDSKKSNS-SPSRDRKPHDHKATYDTKRPNEETKSV 1561
+ + S + D G +S+ + S +R+ +P + AT + E S
Sbjct: 1070 KQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISS- 1128
Query: 1562 DKNPCKDRE--KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK-STVKPKPQL 1618
+ P + + V+ N E + + +N T+ E + + K + V P
Sbjct: 1129 EPTPMDEMSTPRDVMSDETNNEETESPSQEFVN--ITKYESSLYSQEYSKPADVTPLNGF 1186
Query: 1619 SHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLD 1678
S S+ +A DYN S S + EE + S L+D + K S
Sbjct: 1187 SEGSK---------TDATDGKDYNASASTISPPSSMEEDKFSRSA-LRDAYCSEVKAS-- 1234
Query: 1679 TAAVVQVGISRNQSHS-SPSVSPSRSHSP 1706
T ++ IS S SPS SPS S SP
Sbjct: 1235 TTLDIKDSISAVSSEKVSPSKSPSLSPSP 1263
Score = 51.2 bits (121), Expect = 9e-06
Identities = 44/197 (22%), Positives = 88/197 (44%), Gaps = 8/197 (4%)
Query: 1595 ETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKE 1654
+T++++ + + K KP P S S + T E + + +S+ V VK+
Sbjct: 532 QTKLKQRADSRESLKPAAKPLPSKSVRKE-SKEETPEVTKVNHVEKPPKVESKEKVMVKK 590
Query: 1655 EESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPS-GSQTRS 1713
++ I + K + EK S + + V+ ++ Q+ V P + + +T+
Sbjct: 591 DKP---IKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA---TDVKPKAAKEKTVKKETKV 644
Query: 1714 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773
+ + K+ KK++K KK +K KK + + E++K +K + KK+ K+
Sbjct: 645 KPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
Query: 1774 KDKEKEKEKDDQKVKSV 1790
KE +KE ++ K V
Sbjct: 705 PPKEVKKEVKKEEKKEV 721
Score = 43.9 bits (102), Expect = 0.001
Identities = 40/180 (22%), Positives = 75/180 (41%), Gaps = 6/180 (3%)
Query: 1607 IDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEE-SSGNISKDL 1665
+ K + + P+++ + + E+ E +E+ SV E+E S +
Sbjct: 557 VRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPV 616
Query: 1666 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1725
K ++ EK + A + + + ++ P P + + E +
Sbjct: 617 KAEVAEKQATDVKPKAAKEKTVKK-ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP 675
Query: 1726 SK---KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEK 1782
K KK+ KKE KK +K K+ KK K E++K K + KK+ K+ K+ +KE +K
Sbjct: 676 KKEEVKKEVKKEIKKEEK-KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKK 734
Score = 43.5 bits (101), Expect = 0.002
Identities = 36/125 (28%), Positives = 59/125 (47%), Gaps = 8/125 (6%)
Query: 978 PSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK-----RKNDGSAVSKKE 1032
P D + V E + E K++ +KD +E+ K K G KTK +K+DG +
Sbjct: 2212 PRHPDVSMVDPEALAIEQNLGKAL-KKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAA 2270
Query: 1033 NIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAH 1092
+ KPA + R SP+ + ++KA + T T K++ +KD++ +
Sbjct: 2271 S-PKPAGLKESSDKVSRVASPKKKESVEKAAKPT-TTPEVKAARGEEKDKETKNAANASA 2328
Query: 1093 SKSAK 1097
SKSAK
Sbjct: 2329 SKSAK 2333
Score = 38.5 bits (88), Expect = 0.059
Identities = 105/520 (20%), Positives = 179/520 (34%), Gaps = 114/520 (21%)
Query: 900 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEE----SEGFLNPELLE 955
EK D +D E+ SE + K + GEE S +P E
Sbjct: 916 EKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDE 975
Query: 956 TSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 1015
S K+ + E + + S DD +E MD E+I K +E+ + E D+
Sbjct: 976 ESAKAEADAYIREKRES----VASGDDRA---EEDMD-EAIE-KGEAEQSEEEADEEDKA 1026
Query: 1016 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERE-------------RSPRSEPPIKKA 1062
D + + + + ++ ++ E E + +SP EP
Sbjct: 1027 EDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIH 1086
Query: 1063 KEETP---KTDNTKSSSSSQKDEKITGTPRKAHSKSAKE-HQETKPVKEEKVKKDYSKDV 1118
E P +++ T S +++D+ T +++S E E P+ E +D D
Sbjct: 1087 DETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDE 1146
Query: 1119 KSEKLT----------TKEEKAKKPNEKNKPLDN---KGEKRKRKTEEKGVDKDFESSSM 1165
+ + T TK E + E +KP D G KT+ KD+ +S+
Sbjct: 1147 TNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATD-GKDYNASAS 1205
Query: 1166 KISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAK-----KIKLNRETGKKIG 1220
IS P ME D K R+ +D A K ++ + +K+
Sbjct: 1206 TIS-----------PPSSMEED--KFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVS 1252
Query: 1221 STENISNTKEPSEKLEST---------------------------SSKVKQEKVKGKVR- 1252
+++ S + P LE T S +V QE V+
Sbjct: 1253 PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCAS 1312
Query: 1253 ------------RKVTGTEGSSSTLVDYTSTSSTG----------GSPV--RKSEEKTDT 1288
+ VTG+ G + T S+ PV S+ K +
Sbjct: 1313 PEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDEN 1372
Query: 1289 KRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1328
+R + M+E D+ +P E V+ ++ P + +ES
Sbjct: 1373 ERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYES 1412
Score = 35.4 bits (80), Expect = 0.50
Identities = 59/267 (22%), Positives = 99/267 (37%), Gaps = 47/267 (17%)
Query: 1531 KSNSSPSRDRKPHDHKATYDTKRPNEETKS---VDKN-PCKDREKHVLEARN--NKESSG 1584
KS S++ P K + K P E+K V K+ P K K + + +KE
Sbjct: 555 KSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEP- 613
Query: 1585 NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE-PDYNE 1643
+P + +V ++Q T VKPK + + + + E + E P
Sbjct: 614 -------SPVKAEVAEKQATD------VKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
Query: 1644 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1703
+ E +K+EE K K+++ ++ K+ + + + P +
Sbjct: 661 AKKEDKTPIKKEE------KPKKEEVKKEVKKEI-----------KKEEKKEPKKEVKKE 703
Query: 1704 HSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKH 1763
P E + KK++K+ KK+ KK K K +E + + K
Sbjct: 704 TPPK------EVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKP 757
Query: 1764 KHKKKKSKKNKDK---EKEKEKDDQKV 1787
K KK+ KD K KEK KV
Sbjct: 758 KVPKKEESVKKDSVAAGKPKEKGKIKV 784
Score = 33.1 bits (74), Expect = 2.5
Identities = 58/237 (24%), Positives = 79/237 (33%), Gaps = 28/237 (11%)
Query: 938 KRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPS---------RDDATPVRD 988
K K E S F+NP LE S EPT E P + D TP
Sbjct: 2091 KHPKTELSPSFINPNPLEWFA-SEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTS 2149
Query: 989 EPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIV--KPAKGPQEKVD 1046
A S T V + + + P D D S + V K P V
Sbjct: 2150 VSESAPSQTDSDVPPETE---ECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQ 2206
Query: 1047 GERERSPRSEPPIKKAKEETPKTDNT-----KSSSSSQKDEKITGTPRKAHSKSAKEHQE 1101
+R SPR P + E + K + K GT K+ S K +
Sbjct: 2207 -DRSPSPR-HPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGK 2264
Query: 1102 TKPVKEE------KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTE 1152
+KP+ K D V S K EKA KP + +GE++ ++T+
Sbjct: 2265 SKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETK 2321
>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
Length = 1462
Score = 102 bits (254), Expect = 3e-21
Identities = 199/958 (20%), Positives = 368/958 (38%), Gaps = 149/958 (15%)
Query: 628 IPTTQAPPLSR-----EEFYREQRRLKEEEKKKSKLDEFTNDFA----KELMEYKKIQKE 678
IP + +PP SR + + R++E + K + L + ++ KE K
Sbjct: 608 IPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKR 667
Query: 679 RRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSH----SRSYSRSPPYP 734
+ S S +S YS S RSS + +SRS S+RSRSYSRS++RS S S SRSP
Sbjct: 668 EKNSES-DQSTYSKYS-DRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSR 725
Query: 735 RRGRGKSRNYRSRSRSHGY--------HRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNV 786
R K ++ SRS Y R++ R + +S S + +
Sbjct: 726 SHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKY 785
Query: 787 PQGETEREYFNRYREVPPPYDMKAYYGRS--VDFRDPFEKERYREWERKYREWYEKYYKG 844
+G +Y E D + +S + EKE+ + ER + + ++ +G
Sbjct: 786 VKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNK--QEKNRG 843
Query: 845 YAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVG----GQSHRSRNIGSNYPE 900
R + + + + L ++RN ++ +R++Y G +S+ R++ N
Sbjct: 844 EEKSKSERECPHSKKRTLKENLSDHLRNG--SKPKRKNYAGSKWDSESNSERDVTKN--- 898
Query: 901 KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
++ D+ S +KE A D + + H K ++ + KS
Sbjct: 899 --------SKNDSHPSSDKEEGEATSDSESEVSEIHIK---------------VKPTTKS 935
Query: 961 REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK 1020
T + ++ ++ R D+E S + + K ++ K +K + K
Sbjct: 936 STNTSLPDDN--------GAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSK-ENLK 986
Query: 1021 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK 1080
R++ K + +K K + K +R+++ +PP++ +EE + D+ K + K
Sbjct: 987 REH----TKKVKEKLKGKKDKKHKAP-KRKQAFHWQPPLEFGEEEEEEIDD-KQVTQESK 1040
Query: 1081 DEKIT---GTPRKAHSKSAKEHQETKPVKEE--KVKKDYSKDVKSEKLTTKEEKAKKPNE 1135
++K++ T + K+ K +E K + V D + K + + A E
Sbjct: 1041 EKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEE 1100
Query: 1136 KNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTP 1195
L N + E+ V E +E+ + SP K++ T
Sbjct: 1101 NVACLQN------IQHVEESVPNGVEDVLQTDDNMEICTPDRSSP--------AKVEETS 1146
Query: 1196 EKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKV 1255
L P I L ++ T+ P ++ S + + KV G+V
Sbjct: 1147 PLGNARLDTPDINIVLKQDMA-----------TEHPQAEVVKQESSMSESKVLGEV---- 1191
Query: 1256 TGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN--------NDNTAPA 1307
G + SSS S +S G S +K + + K + N T+ A
Sbjct: 1192 -GKQDSSS-----ASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSA 1245
Query: 1308 EDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKES 1367
+V ++ VP+ K + ++KS + +P S+ V K + + + P +
Sbjct: 1246 VEVKVLTTVPEMK-----PQGLRIEIKSKNKV----RPGSLFDEV-RKTARLNRRPRNQE 1295
Query: 1368 EPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEK 1427
S++ D S + +S S S + K++ R SV + + ++ST +
Sbjct: 1296 SSSDEQTPSRDDDS------QSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYR 1349
Query: 1428 ESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRA-SSNKDFTPNRDKKTDYDTREYSSSK 1486
+ R +G + RT + S R+ S++ + +R + + YD S S
Sbjct: 1350 SRSYSRSRSRGWY-------SRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSY 1402
Query: 1487 RRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHD 1544
D +R S SR++ S S + + R + G +S+ S S R P +
Sbjct: 1403 TYDSYYSRSR---SRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSE 1457
Score = 95.5 bits (236), Expect = 4e-19
Identities = 182/922 (19%), Positives = 358/922 (38%), Gaps = 110/922 (11%)
Query: 900 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK 959
+K + +G + N+ S + S + + + ++ +KH++R P++ + ++
Sbjct: 190 KKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRR-----------PKVKRSKKR 238
Query: 960 SREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKT 1019
+E + EE P A + +++ +SV KRE KP + ++
Sbjct: 239 RKEASSSEE---------PRNKHAMNPKGHSERSDTNEKRSVDSSAKRE--KPVVRPEEI 287
Query: 1020 KRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETP-------KTDNT 1072
+ + +++ V A+ P+ K+ +P + K+ + T
Sbjct: 288 PPVPENRFLLRRDMPVVTAE-PEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPR 346
Query: 1073 KSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKS----EKLTTKEE 1128
S S D+ + TP + + P E+ K D D S E+ ++
Sbjct: 347 SRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRS 406
Query: 1129 KAKKPNEKNKPLD---NKGEKRKRKTEEKGVDKDFESSSMKISKLEVTE---IVKPSPKR 1182
++ N L + G +KR+ E+K K + + T+ I+ PS
Sbjct: 407 RSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIE 466
Query: 1183 KMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKV 1242
+ T +M + ++++ S S+ ++ K S +++ ++ S + S
Sbjct: 467 SSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSK--SDKDVQSSLTHSSRDSYRSKSH 524
Query: 1243 KQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND 1302
Q +G R + S S + +SS G R S+ + R + E
Sbjct: 525 SQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASK----SPRKTASQLSENKPV 580
Query: 1303 NTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1362
T P + ++ E+V QP+ + P VI + P + K
Sbjct: 581 KTEPLRATM----------------AQNENVV-VQPVVAENIP--VIPLSDSPPPSRWKP 621
Query: 1363 PEKESEPS-EKIQKFTKDVSHEI-IQH-----EVKSSKNSASSEKG-KTKDRDYSVLEKE 1414
+K +PS E+IQ+ +H + IQ +K + +S+S K K + D S K
Sbjct: 622 GQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKY 681
Query: 1415 NPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKK 1474
+ ++S + S+ R + +S S +S H +R+ S++ + N+
Sbjct: 682 SDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASS-------HSRSRSPSSRSHSRNKYSD 734
Query: 1475 TDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNS 1534
+R S + + +R+ S K+S S +K+ E+ L K K
Sbjct: 735 HSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYV----KGRD 790
Query: 1535 SPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKH-VLEARNNKESSGNKLLYILNP 1593
S RK + +++ D +E++ +++EK +E +NK+ N
Sbjct: 791 RSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEK--------NR 842
Query: 1594 PETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
E + + E+ K T+K LS R S R+ + + DSESN
Sbjct: 843 GEEKSKSERECPHSKKRTLKEN--LSDHLRNGSKPKRKNYAGS------KWDSESNSERD 894
Query: 1654 EEESSGNISKDLKDKIV-EKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTR 1712
++S N S DK E +S + + + + S+ + P + + S+ R
Sbjct: 895 VTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQR 954
Query: 1713 SHSSSASSAESQDSKKKKKKKEKKKH-KKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSK 1771
+ S+S S +S+ + K +K KH K ++H K +++ +K +KHK K+K
Sbjct: 955 T-STSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQA 1013
Query: 1772 KNKD------KEKEKEKDDQKV 1787
+ +E+E+E DD++V
Sbjct: 1014 FHWQPPLEFGEEEEEEIDDKQV 1035
Score = 84.0 bits (206), Expect = 1e-15
Identities = 232/1163 (19%), Positives = 398/1163 (34%), Gaps = 203/1163 (17%)
Query: 647 RLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSR 706
R ++ KK+ L + +K K +R RS SRS S S S R K
Sbjct: 449 RRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERS-SRSSSLSSHHSSKRDWSKSDKDV 507
Query: 707 SGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRY 766
S S S+SHS+SYSR G +SR S+S SH RS+SRS +
Sbjct: 508 QSSLTHSSRDSYRSKSHSQSYSR-------GSSRSRT-ASKSSSHSRSRSKSRSSSKSGH 559
Query: 767 HSR-SRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKE 825
R S+SP+ Q + V V P + A + D
Sbjct: 560 RKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQP--VVAENIPVIPLSDSPPPS 617
Query: 826 RYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVG 885
R++ ++ ++ YE+ + A LP+ S ++ ++
Sbjct: 618 RWKPGQKPWKPSYERIQEMKA--------------KTTHLLPIQ---STYSLANIKETGS 660
Query: 886 GQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEES 945
S+ R EK S D Q +K ++ SE++P + R R S
Sbjct: 661 SSSYHKR-------EKNSESD---QSTYSKYSDRSSESSP-------RSRSRSSRSRSYS 703
Query: 946 EGFLNPELLETSR-KSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEK 1004
+ L +S +SR P+ ++ D + S ++ S+S
Sbjct: 704 RSYTRSRSLASSHSRSRSPSSRSHSRNK-------------YSDHSQCSRSSSYTSISSD 750
Query: 1005 DKRE---RDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKK 1061
D R R + K + K S+ S+K K KG + RS
Sbjct: 751 DGRRAKRRLRSSGKKNSVSHKKHSSS-SEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSS 809
Query: 1062 AKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE 1121
E++ + +++ S+Q+ EK G + H+K K E K E + + +K E
Sbjct: 810 DSEQS----SVQATQSAQEKEK-QGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLK-E 863
Query: 1122 KLTTKEEKAKKPNEKNKPLDNKGEK-RKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSP 1180
L+ KP KN G K E+ V K+ ++ S S E E S
Sbjct: 864 NLSDHLRNGSKPKRKNYA----GSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSE 919
Query: 1181 KR------KMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTK-EPSE 1233
K++P T+ T D + K K T GS N N + +P +
Sbjct: 920 SEVSEIHIKVKPTTKSSTNTSLPDD---NGAWKSSKQRTSTSDSEGSCSNSENNRGKPQK 976
Query: 1234 KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVI 1293
+ +K+E K KV+ K+ G K D K
Sbjct: 977 HKHGSKENLKREHTK-KVKEKLKG---------------------------KKDKKHKAP 1008
Query: 1294 KTMEEYNNDNTAPAEDVIIMIQVPQSKWDKD-DFESEEEDVKSTQPISSVGKPASVIKNV 1352
K + ++ W +F EEE+ + ++ K V +N
Sbjct: 1009 KRKQAFH--------------------WQPPLEFGEEEEEEIDDKQVTQESKEKKVSENN 1048
Query: 1353 STKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLE 1412
T NI+K EK SE + T VS ++ Q SK S S
Sbjct: 1049 ETIKDNILK-TEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTA------------ 1095
Query: 1413 KENPEKRKNSTQPEKESNLDRLNEQGNFKSLS--QSSKEARTSDKHDSTRASSNKDF-TP 1469
LN + N L Q +E+ + D + N + TP
Sbjct: 1096 ---------------------LNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTP 1134
Query: 1470 NRDKKTDYDTREYSSSKRRD--EKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTG 1527
+R + + R D + N + ++ + + Q++ E + L + G
Sbjct: 1135 DRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQ 1194
Query: 1528 DSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKL 1587
DS ++ + + + A + +DK + L A N SS ++
Sbjct: 1195 DSSSASLASAGESTGKKEVAE------KSQINLIDKKWKPLQGVGNLAAPNAATSSAVEV 1248
Query: 1588 LYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSE 1647
+ PE + + +I +K K ++ S D R+T P ES S+
Sbjct: 1249 KVLTTVPEMKPQGLRIE-------IKSKNKVRPGSLF--DEVRKTARLNRRPRNQESSSD 1299
Query: 1648 SNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPS 1707
++++S + K K++ +R+ S+S S SRS S +
Sbjct: 1300 EQTPSRDDDSQSRSPSRSRSKSETKSRHR-----------TRSVSYSH---SRSRSRSST 1345
Query: 1708 GS-QTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK 1766
S ++RS+S S S + + + + +K H+ + + + + +S+ + +
Sbjct: 1346 SSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYD 1405
Query: 1767 KKKSKKNKDKEKEKEKDDQKVKS 1789
S+ ++ + +S
Sbjct: 1406 SYYSRSRSRSRSQRSDSYHRGRS 1428
Score = 80.1 bits (196), Expect = 2e-14
Identities = 219/1180 (18%), Positives = 411/1180 (34%), Gaps = 179/1180 (15%)
Query: 685 RSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNY 744
RS+S S S SS T + R R+Y S+ S P R +S +
Sbjct: 346 RSRS-CSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQ 404
Query: 745 RSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPP 804
RSRS S+ + S + + +H + R + + + K+ Q R + R +
Sbjct: 405 RSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKK---QKHCRRHKQTKKRRILI 461
Query: 805 PYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPER 864
P D+++ + + ++ER ++ S+ R+ ++
Sbjct: 462 PSDIESSKSSTRRMKSSCDRER----------------SSRSSSLSSHHSSKRDWSKSDK 505
Query: 865 FLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENA 924
+ S T R+ Y +S + GS+ S H ++S+ K ++
Sbjct: 506 DV-----QSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSH-----SRSRSKSRSSS 555
Query: 925 PGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDAT 984
+ K RK + E L + E V+ +++ V+P D
Sbjct: 556 KSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPP 615
Query: 985 PVRDEP--------------MDAESITFKSV-------------SEKDKRERDKPKAKGD 1017
P R +P M A++ + S +R+K
Sbjct: 616 PSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQ 675
Query: 1018 KTKRK-NDGSAVSKKENIVKPAKGPQEKVDGERERS-----PRSEPPIKKAKEETPKTDN 1071
T K +D S+ S + + ++ R RS RS P ++ +D+
Sbjct: 676 STYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDH 735
Query: 1072 TKSSSSS-----------------QKDEKITGTPRKAHSKSAKEHQETKPVK-------- 1106
++ S SS + K K HS S+++ +K VK
Sbjct: 736 SQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCV 795
Query: 1107 ----EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES 1162
E + DYS D + + + +K + + +++ R E+ +++
Sbjct: 796 RKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPH 855
Query: 1163 SSMKISKLEVTEIVK--PSPKRK----MEPDTE-KMDRTPEKDKISLSAPAKKIKLNRET 1215
S + K +++ ++ PKRK + D+E +R K+ + S P+ + T
Sbjct: 856 SKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEAT 915
Query: 1216 GKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTG 1275
I +P+ K ST++ + + K ++ T T S + + S ++ G
Sbjct: 916 SDSESEVSEIHIKVKPTTK-SSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSN--SENNRG 972
Query: 1276 GSPVRKSEEKTDTKRTVIKTMEE-----YNNDNTAPAEDVIIMIQVPQSKWDKDDFESEE 1330
K K + KR K ++E + + AP Q P +F EE
Sbjct: 973 KPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPL------EFGEEE 1026
Query: 1331 EDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVK 1390
E+ + ++ K V +N T NI+K EK SE + T VS ++ Q
Sbjct: 1027 EEEIDDKQVTQESKEKKVSENNETIKDNILK-TEKSSEEDLSGKHDTVTVSSDLDQFTKD 1085
Query: 1391 SSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLS--QSSK 1448
SK S S LN + N L Q +
Sbjct: 1086 DSKLSISP---------------------------------TALNTEENVACLQNIQHVE 1112
Query: 1449 EARTSDKHDSTRASSNKDF-TPNRDKKTDYDTREYSSSKRRD--EKNELTRRKDSPSRNK 1505
E+ + D + N + TP+R + + R D + N + ++ + +
Sbjct: 1113 ESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQ 1172
Query: 1506 DSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNP 1565
Q++ E + L + G DS ++ + + + A + +DK
Sbjct: 1173 AEVVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVA------EKSQINLIDKKW 1226
Query: 1566 CKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLS 1625
+ L A N SS ++ + PE + + +I +K K ++ S
Sbjct: 1227 KPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRI-------EIKSKNKVRPGSLF- 1278
Query: 1626 SDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQV 1685
D R+T P ES S+ ++++S + K K++ + V
Sbjct: 1279 -DEVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRS---VSY 1334
Query: 1686 GISRNQSHSSPSVSPSRSHSPSGS-------QTRSHSSSASSAESQ--DSKKKKKKKEKK 1736
SR++S SS S SRS+S S S +TRS SSS S +S S+ + +
Sbjct: 1335 SHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYD 1394
Query: 1737 KHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDK 1776
H + + + ++ + + + + +S + +
Sbjct: 1395 PHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSR 1434
Score = 76.6 bits (187), Expect = 2e-13
Identities = 202/1105 (18%), Positives = 395/1105 (35%), Gaps = 142/1105 (12%)
Query: 697 RSSYTYSKSRSGSTRSRSYSRSFSRS---HSRSYSRSPPYPRRGRGKSRNYRSRSRSHGY 753
R T+S+ S+ S S S S S S H RS RR + K R RS+
Sbjct: 189 RKKPTHSEGSDSSSNSSSSSESSSESELEHERS--------RRRKHKRRPKVKRSKKRRK 240
Query: 754 HRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYG 813
S S P R H+ + + R + KR+V + R E+PP + +
Sbjct: 241 EASSSEEP--RNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLR 298
Query: 814 RSVDFRD-----------PFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSP 862
R + P ++ + R+ + Y + R + ++
Sbjct: 299 RDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDS 358
Query: 863 ERFLPLNIRNSPFTRGRR----EDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKE 918
P R R E + G S S + E+ ++ + N +
Sbjct: 359 SETPPHWKEEMQRLRAYRPPSGEKWSKGDK-LSDPCSSRWDERSLSQRSRSWSYNGYYSD 417
Query: 919 KESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLP 978
+ G K + +K K +K + + R+ P+ +E +K+ + +
Sbjct: 418 LSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKS 477
Query: 979 SRDDATPVRDEPMDAESITFKSVSEKDKR-ERDKPKAKGDKTKRKNDGSAVSKKENIVKP 1037
S D R + + + + S+ DK + + D + K+ + S+ + +
Sbjct: 478 SCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRT 537
Query: 1038 AKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAK 1097
A K+ + ++SSS S ++ + +PR K+A
Sbjct: 538 A---------------------SKSSSHSRSRSKSRSSSKSGHRKRASKSPR----KTAS 572
Query: 1098 EHQETKPVKEEKVKKDYSKD-------VKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK 1150
+ E KPVK E ++ +++ V +E + P + KP G+K +
Sbjct: 573 QLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKP----GQKPWKP 628
Query: 1151 TEEKGVDKDFES-------SSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLS 1203
+ E+ + ++ S+ ++ ++ T KR+ ++++ + D+ S S
Sbjct: 629 SYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSES 688
Query: 1204 APAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSS 1263
+P + + +R + + S + S L S+ S+ + + R K + S
Sbjct: 689 SPRSRSRSSR--------SRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYS-DHSQCS 739
Query: 1264 TLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDV------IIMIQVP 1317
YTS SS G ++ + K +V +++ T ++ V + +
Sbjct: 740 RSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYS 799
Query: 1318 QSKWDKD-DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKF 1376
+S+ D +SE+ V++TQ K + + + + N + EK E
Sbjct: 800 ESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKN--RGEEKSKSERECPHSK 857
Query: 1377 TKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNE 1436
+ + + H SK + G D + S E++ + KN + P + E
Sbjct: 858 KRTLKENLSDHLRNGSKPKRKNYAGSKWDSE-SNSERDVTKNSKNDSHPSSD------KE 910
Query: 1437 QGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRR----DEKN 1492
+G S S+S +T++S+N D + SSK+R D +
Sbjct: 911 EGEATSDSESEVSEIHIKVKPTTKSSTNTSLPD--------DNGAWKSSKQRTSTSDSEG 962
Query: 1493 ELTRRKDSPSRNKDSASGQKNKPREE--RDLPKKGTGDSKKSNSSPSRDRKPH------- 1543
+ +++ + + G K + E + + +K G K + +P R + H
Sbjct: 963 SCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEF 1022
Query: 1544 --DHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKE 1601
+ + D K+ +E+K +K ++ E ++SS L + + +
Sbjct: 1023 GEEEEEEIDDKQVTQESK--EKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDLD 1080
Query: 1602 QITGQIDKSTVKPKPQ--------LSHSSRLSSDLTRETDEAAFEPDYNE---SDSESNV 1650
Q T K ++ P L + + + ++ D E D S
Sbjct: 1081 QFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPA 1140
Query: 1651 SVKEEESSGNISKDLKD-KIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGS 1709
V+E GN D D IV K + + Q + + +S S+S S+ G
Sbjct: 1141 KVEETSPLGNARLDTPDINIVLKQDMATEHP---QAEVVKQES----SMSESKVLGEVGK 1193
Query: 1710 QTRSHSSSASSAESQDSKKKKKKKE 1734
Q S +S AS+ ES K+ +K +
Sbjct: 1194 QDSSSASLASAGESTGKKEVAEKSQ 1218
Score = 52.8 bits (125), Expect = 3e-06
Identities = 138/683 (20%), Positives = 249/683 (36%), Gaps = 103/683 (15%)
Query: 624 HSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSF 683
HS ++ +S ++ R +RRL+ KK S + + +++ + K ++ R S
Sbjct: 735 HSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSC 794
Query: 684 SRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRN 743
R YS+SRS S YS +S ++ + ++G+ R
Sbjct: 795 VRK---------------YSESRS----SLDYSSDSEQSSVQATQSAQEKEKQGQ-MERT 834
Query: 744 YRSRSRSHGYHRSRS-RSPPY--RRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYR 800
+ + ++ G +S+S R P+ +R + S G P ++N + + E N R
Sbjct: 835 HNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSE-SNSER 893
Query: 801 EVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENF 860
+V K S D E E + E + E + K +P ++
Sbjct: 894 DV-----TKNSKNDSHPSSDKEEGEATSDSESEVSEIHIK--------VKPTTKSSTNTS 940
Query: 861 SPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKE 920
P+ S R D G S+ N G K +++ ++ K KEK
Sbjct: 941 LPD---DNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKL 997
Query: 921 SENAPGDGKGNKHKKHR--KRRK----------GEESEGFLNPELLETSRKSREPTGVEE 968
KG K KKH+ KR++ GEE E ++ + + +++S+E E
Sbjct: 998 --------KGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDK--QVTQESKEKKVSEN 1047
Query: 969 NKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAV 1028
N+T +L + + +E + + T S+ D+ +D K T A+
Sbjct: 1048 NETIKDNILKTEKSS----EEDLSGKHDTVTVSSDLDQFTKDDSKLSISPT-------AL 1096
Query: 1029 SKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1088
+ +EN+ + + E P + + + +SS + ++ G
Sbjct: 1097 NTEENV-----ACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNA 1151
Query: 1089 R--------KAHSKSAKEHQETKPVKEE------KVKKDYSK-DVKSEKLTTKEEKAKKP 1133
R A EH + + VK+E KV + K D S L + E K
Sbjct: 1152 RLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKK 1211
Query: 1134 NEKNKPLDNKGEKRKRKTEEKG---VDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEK 1190
K N +K+ + + G SS++++ L +KP R K
Sbjct: 1212 EVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNK 1271
Query: 1191 MDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGK 1250
+ D++ K +LNR + S++ T + +S S + K + K
Sbjct: 1272 VRPGSLFDEV-----RKTARLNRRPRNQESSSD--EQTPSRDDDSQSRSPSRSRSKSETK 1324
Query: 1251 VRRKVTGTEGSSSTLVDYTSTSS 1273
R + S S +STSS
Sbjct: 1325 SRHRTRSVSYSHSRSRSRSSTSS 1347
Score = 43.1 bits (100), Expect = 0.002
Identities = 77/347 (22%), Positives = 131/347 (37%), Gaps = 51/347 (14%)
Query: 1441 KSLSQSSKEARTSDKH-DSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD 1499
KS+ ++ R H + + +SSN + +++ E+ S+RR K + K
Sbjct: 179 KSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESEL---EHERSRRRKHKRR-PKVKR 234
Query: 1500 SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETK 1559
S R K+++S ++ PR + + KG + +N E +
Sbjct: 235 SKKRRKEASSSEE--PRNKHAMNPKGHSERSDTN-----------------------EKR 269
Query: 1560 SVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLS 1619
SVD + REK V+ N+ L + P E E + KP +S
Sbjct: 270 SVDSSA--KREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVS 327
Query: 1620 HSSRLSSDL------TRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKA 1673
S R T + E D ++S SE+ KEE + + K
Sbjct: 328 KSGRKIKGRGTIRYHTPPRSRSCSESDDDDS-SETPPHWKEEMQRLRAYRPPSGEKWSKG 386
Query: 1674 KESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKK- 1732
+ D + SR S RS S S + S S+A + ++K+KK
Sbjct: 387 DKLSDPCS------SRWDERSLSQ----RSRSWSYNGYYSDLSTARHSGHHKKRRKEKKV 436
Query: 1733 KEKKKHKKHKKHKKHKKHAGTEVELEKS-QKHKHKKKKSKKNKDKEK 1778
K KKK KK K ++HK+ + + + K ++ K + D+E+
Sbjct: 437 KHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRER 483
Score = 37.0 bits (84), Expect = 0.17
Identities = 27/87 (31%), Positives = 35/87 (40%), Gaps = 1/87 (1%)
Query: 642 YREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYT 701
Y+ R + S D + + Y + R RS RS S + G SY+R S +
Sbjct: 1377 YKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRS-QRSDSYHRGRSYNRRSRS 1435
Query: 702 YSKSRSGSTRSRSYSRSFSRSHSRSYS 728
S S RSYS S S S YS
Sbjct: 1436 CRSYGSDSESDRSYSHHRSPSESSRYS 1462
Score = 32.7 bits (73), Expect = 3.3
Identities = 15/62 (24%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Query: 1725 DSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKK-KSKKNKDKEKEKEKD 1783
+ K+KK + + + +E+E E+S++ KHK++ K K++K + KE
Sbjct: 186 EKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSS 245
Query: 1784 DQ 1785
++
Sbjct: 246 EE 247
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 99.8 bits (247), Expect = 2e-20
Identities = 197/968 (20%), Positives = 382/968 (39%), Gaps = 151/968 (15%)
Query: 889 HRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGF 948
H S + G KL R G N K E+ + A + K R+ ++ E +
Sbjct: 233 HDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLK--REVPLSDDDESY 290
Query: 949 LNPELLETSRKSREPTGVEEN-----KTDSLF-----VLPSRDDATPVRDE----PMDAE 994
+ E +S P+ V+EN + DSL +LPS+ DE D E
Sbjct: 291 TDSE----EAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDE 346
Query: 995 SITF----KSVSEKDKRERDKPKAKGDKTKRKNDGSAVSK--KENIVKPAKGPQEKVDGE 1048
I + + K++R+ ++P+A+ K + + K K KP++ +
Sbjct: 347 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 406
Query: 1049 RERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE 1108
E + +++ I + P+T N S ++K+ ++G EH++ VK +
Sbjct: 407 DEEALQNKK-ISTSCSVIPETSN--SDMQTKKEYVVSG-----------EHKQKGKVKRK 452
Query: 1109 KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLD-NKGEKRKRKTEEKG-VDKDF------ 1160
K+ +K+ ++++L K+EK K N + L N G KT E+G K F
Sbjct: 453 L--KNQNKNKENQEL--KQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDT 508
Query: 1161 --------------------ESSSMKISKLEVTEIVKP-SPKRKMEPDTEKMDRT----- 1194
E S + + + P S + ++PD + D T
Sbjct: 509 SLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFL 568
Query: 1195 PEKDKISLSAPAKKIKLNRETGKKIGSTENIS-NTKEPSEKLESTSSKVKQEKVKGKVRR 1253
PE + +K K ++ + G N ++ S E++ +K+ +GK +
Sbjct: 569 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 628
Query: 1254 KVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIM 1313
K K EK K+ + E+Y ++A +++
Sbjct: 629 K---------------------HKLKHKEREKEKHKKEIEGEKEKYKTKDSA--KELQRS 665
Query: 1314 IQVPQSKWDKDDFESEEED---VKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPS 1370
++ + W ++ F+S+E + + ++ K + + KN+ S K+ KE
Sbjct: 666 VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFK 725
Query: 1371 EKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESN 1430
E+ K K+ + ++K K + KD +++ L E+ EKE +
Sbjct: 726 EERDKIKKESEKSFREEKIKDLKEERENIP-TDKDSEFTSLGMSAIEESIGLHLVEKEID 784
Query: 1431 LDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDE 1490
+++ ++ + K S+ E R+ K K F ++KK + E+ S K +
Sbjct: 785 IEK--QEKHIKE-SKEKPEKRSQIKEKDIEKMERKTF--EKEKKIKH---EHKSEK---D 833
Query: 1491 KNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYD 1550
K +L+ D S K +E + K K + SR++ H D
Sbjct: 834 KLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH----D 889
Query: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
++P +E ++ + +EKH++E + NK+S ++ Y + EK++ + +KS
Sbjct: 890 KEKPEKE-----RHLAESKEKHLME-KKNKQSDNSE--YSKSEKGKNKEKDRELDKKEKS 941
Query: 1611 TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNIS------KD 1664
K +++S + + ++ + D N++ E +S+KE+ + KD
Sbjct: 942 RDKESINITNSKHI------QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 995
Query: 1665 LKDKIVEKAKESLDTAAVVQVG----ISRNQSHSSPSVSP-SRSHSPSGSQTRSHSSSAS 1719
KDK +++ KE +Q+ + P SP S+ P + + +
Sbjct: 996 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1055
Query: 1720 SAESQDSKKKKKKKE-KKKHKKHKKHKKHKKHAG---TEVELEKSQKHKHKKKKSKKNKD 1775
S E S K + ++ KKHK+ K K+ ++ E++++ +K KH +S KNK+
Sbjct: 1056 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTES-KNKE 1114
Query: 1776 KEKEKEKD 1783
+ K +
Sbjct: 1115 LTRSKSSE 1122
Score = 97.8 bits (242), Expect = 8e-20
Identities = 179/882 (20%), Positives = 350/882 (39%), Gaps = 94/882 (10%)
Query: 917 KEKESENAPGDGKGNKHKKHRKR--RKGEESEGFLNPELLETSRKSREPTGVEENK-TDS 973
KE+ EN P K + K K K +S+ +L +S +S + ++ K + S
Sbjct: 360 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 419
Query: 974 LFVLP--SRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKK 1031
V+P S D ++ + E V K K + + + K++ +G ++
Sbjct: 420 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKE--NQELKQEKEGKENTRI 477
Query: 1032 ENI-----VKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITG 1086
N+ + ++ +E+ + + SP+ + + T K+ S ++ +
Sbjct: 478 TNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQ 537
Query: 1087 TPRKAHSKSAKEHQETKP--VKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKG 1144
K +P V+ + + ++ + S K +EK+K ++K+ L+ G
Sbjct: 538 EHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSK--HQKDFHLEF-G 594
Query: 1145 EKRKRKTEEKGVDKDFESSSMKISKL--EVTEIVKPSPKRK-MEPDTEKMDRTPEKDKIS 1201
EK K +++ FE+S + K+ E + K K K E + K + EK+K
Sbjct: 595 EKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYK 654
Query: 1202 LSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGS 1261
AK+++ + E ++ EN + E + + + + K K+ + + + +
Sbjct: 655 TKDSAKELQRSVEFDREFWK-ENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 713
Query: 1262 SSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKW 1321
V ++K EK+ + + EE N T S++
Sbjct: 714 KEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDK-----------DSEF 762
Query: 1322 DKDDFESEEEDV--KSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD 1379
+ EE + + + K IK KP + EK+ E E+ + F K+
Sbjct: 763 TSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER-KTFEKE 821
Query: 1380 VSHEIIQHEVKSSKN----SASSEKGKTKDRDYSV-LEK--ENPEKRKNSTQPEKESNLD 1432
I+HE KS K+ S +K K KD+ YS EK + EK KN+ +K + +
Sbjct: 822 KK---IKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDRE 878
Query: 1433 RLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR-RDEK 1491
+ E+ + K KE ++H S K ++K++D EYS S++ ++++
Sbjct: 879 KSREKMDRKH----DKEKPEKERH--LAESKEKHLMEKKNKQSD--NSEYSKSEKGKNKE 930
Query: 1492 NELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKA-TYD 1550
+ K SR+K+S + +K +E G+ + S K D T D
Sbjct: 931 KDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD 990
Query: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
K +++ K +D+ +D+ K ++ N LL + + +
Sbjct: 991 GKEKDKKDKDIDRYKERDKHKDKIQI--------NSLLKLKSEAD--------------- 1027
Query: 1611 TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIV 1670
KPKP+ SS S D TR ++ D ++ E +S+K+ E K K+KI
Sbjct: 1028 --KPKPK---SSPASKD-TRPKEKRLVNDDLMQTSFERMLSLKDLEIE-QWHKKHKEKIK 1080
Query: 1671 EKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK 1730
+K KE L +++ I + H+P+ S+ + + S SS + K+K
Sbjct: 1081 QKEKERLRNRNCLELKIKDKEK---------TKHTPTESKNKELTRSKSSEVTDAYTKEK 1131
Query: 1731 KKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKK 1772
+ K+ ++ K+ G + + ++ + +++K
Sbjct: 1132 QPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1173
Score = 67.8 bits (164), Expect = 9e-11
Identities = 194/977 (19%), Positives = 349/977 (35%), Gaps = 147/977 (15%)
Query: 916 SKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLF 975
+K +SEN+ D N +K R+ ++ + +E S S+E K F
Sbjct: 7 TKPIQSENSDSDS--NMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPF 64
Query: 976 VLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIV 1035
+ +P R+E D S+ +K +K K K + +K+ ++ +
Sbjct: 65 TI------SPSRNEERD---------SDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLS 109
Query: 1036 KPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPR-KAHSK 1094
+ + R+ SP S P + TP T SSSS QKD+ R +
Sbjct: 110 ERKQMALLMQMTARDNSPDSTP--NHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLH 167
Query: 1095 SAKEHQETKPVKE------EKVKKDYS-------------KDVKSEKLTTKEEKAKKPNE 1135
A + K VKE KD++ DV + + + +
Sbjct: 168 MAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLD 227
Query: 1136 KNKPLDNKGEKRKR---KTEEKGVDKDFESSSMKISKLEV--TEIVKPSPKRK--MEPDT 1188
+ PL + R K + F+++ ++V TE ++ KR+ + D
Sbjct: 228 DDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDD 287
Query: 1189 EKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEP-----------SEKLES 1237
E + E ++ S+ + I E I ++ I +K P + E
Sbjct: 288 ESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEE 347
Query: 1238 TSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTME 1297
+ + + K +RK E + L + P +K R + + E
Sbjct: 348 INKMIDDRHILRKEQRKENEPEAEKTHLF---AKQEKAFYPKSFKSKKQKPSRVLYSSTE 404
Query: 1298 EYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPS 1357
+ + + +P++ D ++++E V S + GK +KN +
Sbjct: 405 SSDEEALQNKKISTSCSVIPET--SNSDMQTKKEYVVSGEH-KQKGKVKRKLKNQNKNKE 461
Query: 1358 NIVKYPEKESEPSEKIQKFT-----------------------KDVSHEIIQH--EVKSS 1392
N EKE + + +I T KD + + H KS
Sbjct: 462 NQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSP 521
Query: 1393 KNSAS-SEKGKTKDRDYSVLEKENPEKRKNSTQPE----KESNLDRLNEQGNFKSLSQSS 1447
K+S SEK T + +P + S QP+ + + L E + KS
Sbjct: 522 KHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKE 581
Query: 1448 KEARTSDKHDSTRASSN-----KDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS 1502
K D H SN +D +P + +D ++ + +K++L ++
Sbjct: 582 KSKHQKDFHLEFGEKSNAKIKDEDHSPTFE-NSDCTLKKMDKEGKTLKKHKLKHKEREKE 640
Query: 1503 RNKDSASGQKNKPREE---RDLPKKGTGDSK-------KSNSSPSRDRKPHDHKATYDTK 1552
++K G+K K + + ++L + D + KS+ + T + K
Sbjct: 641 KHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKK 700
Query: 1553 RPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTV 1612
E+ DK+ +EKHV + RN KE I E +E+I ++
Sbjct: 701 SKLEKNIKDDKS---TKEKHVSKERNFKEERDK----IKKESEKSFREEKIKDLKEEREN 753
Query: 1613 KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVS-VKEEESSGNISKDLKDKIVE 1671
P + S + L E+ E D E +KE + +K+K +E
Sbjct: 754 IPTDKDSEFTSLGMSAIEES--IGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIE 811
Query: 1672 K------------------AKESLDTAAVVQVGISRNQ--SHSSPSVSPSRSHSPSGSQT 1711
K K+ LD + V +++ SH + S + +
Sbjct: 812 KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 871
Query: 1712 RSHSSSASSAESQDSKKKKKKKEKKKH-----KKHKKHKKHKKHAGTEVELEKSQKHKHK 1766
+ S E D K K+K EK++H +KH KK+K+ + E KS+K K+K
Sbjct: 872 KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNS--EYSKSEKGKNK 929
Query: 1767 KKKSKKNKDKEKEKEKD 1783
+K + +K KEK ++K+
Sbjct: 930 EKDRELDK-KEKSRDKE 945
Score = 64.7 bits (156), Expect = 8e-10
Identities = 119/563 (21%), Positives = 210/563 (37%), Gaps = 117/563 (20%)
Query: 824 KERYREWERKYREWYEKYYKGYAAGAQPRPSANREN-FSPERFLPLNIRNSPFTRGRRED 882
KER +E +K E ++ YK + + + S + F E F F ED
Sbjct: 635 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF---------FKSDETED 685
Query: 883 YVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKG 942
H S + EK S + N KD+ +KEK K K+ R + K
Sbjct: 686 LFLNMEHESLTL-----EKKSKLE-KNIKDDKSTKEKHVS------KERNFKEERDKIK- 732
Query: 943 EESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVS 1002
+ESE E ++ ++ RE +++ + + + +++ + + + I +
Sbjct: 733 KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH---LVEKEIDIEKQE 789
Query: 1003 EKDKRERDKPKAKG---DKTKRKNDGSAVSKKENIVKPAKGPQEK------VDGERERSP 1053
+ K ++KP+ + +K K + K++ I K ++K VD +E+
Sbjct: 790 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 849
Query: 1054 RSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKD 1113
+K +E K+ NT + + EK + K ++H + KP KE + +
Sbjct: 850 LYSHHTEKCHKEGEKSKNTAAIKKTDDREK-------SREKMDRKHDKEKPEKERHLAES 902
Query: 1114 YSKDV--KSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK--------TEEKGVDKDFESS 1163
K + K K + E +K KNK D + +K+++ T K + ++ +SS
Sbjct: 903 KEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSS 962
Query: 1164 SMKISK------LEVTEIVKPSP--------KRKMEPDTEK-MDRTPEKDKISLSAPAKK 1208
+ +K L + E K P K K + D ++ +R KDKI +++
Sbjct: 963 IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS---L 1019
Query: 1209 IKLNRETGKKIGSTENISNTKEPSEK------LESTS--------------------SKV 1242
+KL E K + S P EK L TS K+
Sbjct: 1020 LKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKI 1079
Query: 1243 KQE-------------KVKGKVRRKVTGTEGSSSTLVDYTSTSSTGG--------SPVRK 1281
KQ+ K+K K + K T TE + L S+ T V
Sbjct: 1080 KQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSN 1139
Query: 1282 SEEKTDTKRTVIKTMEEYNNDNT 1304
+ DTK + + +DN+
Sbjct: 1140 RSQSVDTKNVMTLGKSSFVSDNS 1162
Score = 57.0 bits (136), Expect = 2e-07
Identities = 143/766 (18%), Positives = 282/766 (36%), Gaps = 111/766 (14%)
Query: 1111 KKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKL 1170
K ++K ++SE + +KP + + K E V K+ + S KL
Sbjct: 3 KSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL 62
Query: 1171 EVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKK------------------IKLN 1212
T SP R E D++ PEK K A KK L
Sbjct: 63 PFTI----SPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLM 118
Query: 1213 RETGK--KIGSTENISNTKEPSEKLESTSSKVKQEKV-----KGKVRRKVTGTEGSSSTL 1265
+ T + ST N + P++K +SS +++KV +G+ + G +
Sbjct: 119 QMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQV 178
Query: 1266 VDYTSTSS-------TGGSPVRK--SEEKTDTKRTVIKTMEEYNN---DNTAPAED---- 1309
+ S + G +P+ + + D + +I + N D+ P D
Sbjct: 179 KELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASS 238
Query: 1310 -----VIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKN-----------VS 1353
V ++++ + + + DV T+ + + K + + S
Sbjct: 239 GHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQS 298
Query: 1354 TKPSNIVKYPEKESE------PSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRD 1407
PS++ + + E+E S++I + + ++E K + E K D D
Sbjct: 299 VNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDD---EEINKMID-D 354
Query: 1408 YSVLEKENPEKRKNSTQPEKE---SNLDRLNEQGNFKSLSQ-------SSKEARTSDKHD 1457
+L KE ++++N + EK + ++ +FKS Q SS E+ +
Sbjct: 355 RHILRKE--QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQ 412
Query: 1458 STRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPRE 1517
+ + S++ P +EY S +K ++ R+ + ++NK++ ++ K +
Sbjct: 413 NKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGK 472
Query: 1518 ERDLPKKGTGDSKKSNSSPSRD----RKPHDHKATYDTKRPNEETKSVDKNPC--KDREK 1571
E T ++ S +R+ RK K + T K+ C +++
Sbjct: 473 ENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQS 532
Query: 1572 HVLEARNNKE--SSGNKLLYILNPPETQVEKEQITGQIDKSTVKP---KPQLSHSSRLSS 1626
L+ + K S G+ + L P + + + + S+VK K + H
Sbjct: 533 TPLKQEHTKTCLSPGSSEM-SLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHL 591
Query: 1627 DLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVG 1686
+ +++ + D++ + S+ ++K+ + G K K K E+ KE
Sbjct: 592 EFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIE---- 647
Query: 1687 ISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD----------SKKKKKKKEKK 1736
+ + + + S + + S E++D + +KK K EK
Sbjct: 648 -GEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 706
Query: 1737 -KHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKE 1781
K K K K K + E +K +K K + +K KD ++E+E
Sbjct: 707 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERE 752
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 99.8 bits (247), Expect = 2e-20
Identities = 197/968 (20%), Positives = 382/968 (39%), Gaps = 151/968 (15%)
Query: 889 HRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGF 948
H S + G KL R G N K E+ + A + K R+ ++ E +
Sbjct: 256 HDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLK--REVPLSDDDESY 313
Query: 949 LNPELLETSRKSREPTGVEEN-----KTDSLF-----VLPSRDDATPVRDE----PMDAE 994
+ E +S P+ V+EN + DSL +LPS+ DE D E
Sbjct: 314 TDSE----EAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDE 369
Query: 995 SITF----KSVSEKDKRERDKPKAKGDKTKRKNDGSAVSK--KENIVKPAKGPQEKVDGE 1048
I + + K++R+ ++P+A+ K + + K K KP++ +
Sbjct: 370 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 429
Query: 1049 RERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE 1108
E + +++ I + P+T N S ++K+ ++G EH++ VK +
Sbjct: 430 DEEALQNKK-ISTSCSVIPETSN--SDMQTKKEYVVSG-----------EHKQKGKVKRK 475
Query: 1109 KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLD-NKGEKRKRKTEEKG-VDKDF------ 1160
K+ +K+ ++++L K+EK K N + L N G KT E+G K F
Sbjct: 476 L--KNQNKNKENQEL--KQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDT 531
Query: 1161 --------------------ESSSMKISKLEVTEIVKP-SPKRKMEPDTEKMDRT----- 1194
E S + + + P S + ++PD + D T
Sbjct: 532 SLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFL 591
Query: 1195 PEKDKISLSAPAKKIKLNRETGKKIGSTENIS-NTKEPSEKLESTSSKVKQEKVKGKVRR 1253
PE + +K K ++ + G N ++ S E++ +K+ +GK +
Sbjct: 592 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 651
Query: 1254 KVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIM 1313
K K EK K+ + E+Y ++A +++
Sbjct: 652 K---------------------HKLKHKEREKEKHKKEIEGEKEKYKTKDSA--KELQRS 688
Query: 1314 IQVPQSKWDKDDFESEEED---VKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPS 1370
++ + W ++ F+S+E + + ++ K + + KN+ S K+ KE
Sbjct: 689 VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFK 748
Query: 1371 EKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESN 1430
E+ K K+ + ++K K + KD +++ L E+ EKE +
Sbjct: 749 EERDKIKKESEKSFREEKIKDLKEERENIP-TDKDSEFTSLGMSAIEESIGLHLVEKEID 807
Query: 1431 LDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDE 1490
+++ ++ + K S+ E R+ K K F ++KK + E+ S K +
Sbjct: 808 IEK--QEKHIKE-SKEKPEKRSQIKEKDIEKMERKTF--EKEKKIKH---EHKSEK---D 856
Query: 1491 KNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYD 1550
K +L+ D S K +E + K K + SR++ H D
Sbjct: 857 KLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH----D 912
Query: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
++P +E ++ + +EKH++E + NK+S ++ Y + EK++ + +KS
Sbjct: 913 KEKPEKE-----RHLAESKEKHLME-KKNKQSDNSE--YSKSEKGKNKEKDRELDKKEKS 964
Query: 1611 TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNIS------KD 1664
K +++S + + ++ + D N++ E +S+KE+ + KD
Sbjct: 965 RDKESINITNSKHI------QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 1018
Query: 1665 LKDKIVEKAKESLDTAAVVQVG----ISRNQSHSSPSVSP-SRSHSPSGSQTRSHSSSAS 1719
KDK +++ KE +Q+ + P SP S+ P + + +
Sbjct: 1019 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1078
Query: 1720 SAESQDSKKKKKKKE-KKKHKKHKKHKKHKKHAG---TEVELEKSQKHKHKKKKSKKNKD 1775
S E S K + ++ KKHK+ K K+ ++ E++++ +K KH +S KNK+
Sbjct: 1079 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTES-KNKE 1137
Query: 1776 KEKEKEKD 1783
+ K +
Sbjct: 1138 LTRSKSSE 1145
Score = 97.8 bits (242), Expect = 8e-20
Identities = 179/882 (20%), Positives = 350/882 (39%), Gaps = 94/882 (10%)
Query: 917 KEKESENAPGDGKGNKHKKHRKR--RKGEESEGFLNPELLETSRKSREPTGVEENK-TDS 973
KE+ EN P K + K K K +S+ +L +S +S + ++ K + S
Sbjct: 383 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 442
Query: 974 LFVLP--SRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKK 1031
V+P S D ++ + E V K K + + + K++ +G ++
Sbjct: 443 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKE--NQELKQEKEGKENTRI 500
Query: 1032 ENI-----VKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITG 1086
N+ + ++ +E+ + + SP+ + + T K+ S ++ +
Sbjct: 501 TNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQ 560
Query: 1087 TPRKAHSKSAKEHQETKP--VKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKG 1144
K +P V+ + + ++ + S K +EK+K ++K+ L+ G
Sbjct: 561 EHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSK--HQKDFHLEF-G 617
Query: 1145 EKRKRKTEEKGVDKDFESSSMKISKL--EVTEIVKPSPKRK-MEPDTEKMDRTPEKDKIS 1201
EK K +++ FE+S + K+ E + K K K E + K + EK+K
Sbjct: 618 EKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYK 677
Query: 1202 LSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGS 1261
AK+++ + E ++ EN + E + + + + K K+ + + + +
Sbjct: 678 TKDSAKELQRSVEFDREFWK-ENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 736
Query: 1262 SSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKW 1321
V ++K EK+ + + EE N T S++
Sbjct: 737 KEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDK-----------DSEF 785
Query: 1322 DKDDFESEEEDV--KSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD 1379
+ EE + + + K IK KP + EK+ E E+ + F K+
Sbjct: 786 TSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER-KTFEKE 844
Query: 1380 VSHEIIQHEVKSSKN----SASSEKGKTKDRDYSV-LEK--ENPEKRKNSTQPEKESNLD 1432
I+HE KS K+ S +K K KD+ YS EK + EK KN+ +K + +
Sbjct: 845 KK---IKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDRE 901
Query: 1433 RLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR-RDEK 1491
+ E+ + K KE ++H S K ++K++D EYS S++ ++++
Sbjct: 902 KSREKMDRKH----DKEKPEKERH--LAESKEKHLMEKKNKQSD--NSEYSKSEKGKNKE 953
Query: 1492 NELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKA-TYD 1550
+ K SR+K+S + +K +E G+ + S K D T D
Sbjct: 954 KDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD 1013
Query: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
K +++ K +D+ +D+ K ++ N LL + + +
Sbjct: 1014 GKEKDKKDKDIDRYKERDKHKDKIQI--------NSLLKLKSEAD--------------- 1050
Query: 1611 TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIV 1670
KPKP+ SS S D TR ++ D ++ E +S+K+ E K K+KI
Sbjct: 1051 --KPKPK---SSPASKD-TRPKEKRLVNDDLMQTSFERMLSLKDLEIE-QWHKKHKEKIK 1103
Query: 1671 EKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK 1730
+K KE L +++ I + H+P+ S+ + + S SS + K+K
Sbjct: 1104 QKEKERLRNRNCLELKIKDKEK---------TKHTPTESKNKELTRSKSSEVTDAYTKEK 1154
Query: 1731 KKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKK 1772
+ K+ ++ K+ G + + ++ + +++K
Sbjct: 1155 QPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
Score = 68.6 bits (166), Expect = 5e-11
Identities = 199/994 (20%), Positives = 358/994 (36%), Gaps = 158/994 (15%)
Query: 916 SKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLF 975
+K +SEN+ D N +K R+ ++ + +E S S+E K F
Sbjct: 7 TKPIQSENSDSDS--NMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPF 64
Query: 976 VL-PSRDDATPVRDEPMDAES------------ITFKSVSEKDKRERDKPKAKGDKTKRK 1022
+ PSR++ RD D++ ++++ SEK+ E+ K K + K
Sbjct: 65 TISPSRNEE---RDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKST 121
Query: 1023 ND----GSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSS 1078
G +S+++ + + R+ SP S P + TP T SSSS
Sbjct: 122 PVSILFGYPLSERKQMALLMQMTA------RDNSPDSTP--NHPSQTTPAQKKTPSSSSR 173
Query: 1079 QKDEKITGTPR-KAHSKSAKEHQETKPVKE------EKVKKDYS-------------KDV 1118
QKD+ R + A + K VKE KD++ DV
Sbjct: 174 QKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 233
Query: 1119 KSEKLTTKEEKAKKPNEKNKPLDNKGEKRKR---KTEEKGVDKDFESSSMKISKLEV--T 1173
+ + + + + PL + R K + F+++ ++V T
Sbjct: 234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAET 293
Query: 1174 EIVKPSPKRK--MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEP 1231
E ++ KR+ + D E + E ++ S+ + I E I ++ I +K P
Sbjct: 294 EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTP 353
Query: 1232 -----------SEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVR 1280
+ E + + + K +RK E + L + P
Sbjct: 354 LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLF---AKQEKAFYPKS 410
Query: 1281 KSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPIS 1340
+K R + + E + + + +P++ D ++++E V S +
Sbjct: 411 FKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPET--SNSDMQTKKEYVVSGEH-K 467
Query: 1341 SVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFT----------------------- 1377
GK +KN + N EKE + + +I T
Sbjct: 468 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 527
Query: 1378 KDVSHEIIQH--EVKSSKNSAS-SEKGKTKDRDYSVLEKENPEKRKNSTQPE----KESN 1430
KD + + H KS K+S SEK T + +P + S QP+ +
Sbjct: 528 KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTE 587
Query: 1431 LDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSN-----KDFTPNRDKKTDYDTREYSSS 1485
+ L E + KS K D H SN +D +P + +D ++
Sbjct: 588 SEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFE-NSDCTLKKMDKE 646
Query: 1486 KRRDEKNELTRRKDSPSRNKDSASGQKNKPREE---RDLPKKGTGDSK-------KSNSS 1535
+ +K++L ++ ++K G+K K + + ++L + D + KS+ +
Sbjct: 647 GKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 706
Query: 1536 PSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPE 1595
T + K E+ DK+ +EKHV + RN KE I E
Sbjct: 707 EDLFLNMEHESLTLEKKSKLEKNIKDDKS---TKEKHVSKERNFKEERDK----IKKESE 759
Query: 1596 TQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVS-VKE 1654
+E+I ++ P + S + L E+ E D E +KE
Sbjct: 760 KSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEES--IGLHLVEKEIDIEKQEKHIKE 817
Query: 1655 EESSGNISKDLKDKIVEK------------------AKESLDTAAVVQVGISRNQ--SHS 1694
+ +K+K +EK K+ LD + V +++ SH
Sbjct: 818 SKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH 877
Query: 1695 SPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKH-----KKHKKHKKHKK 1749
+ S + + + S E D K K+K EK++H +KH KK+K+
Sbjct: 878 TEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQ 937
Query: 1750 HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1783
+ E KS+K K+K+K + +K KEK ++K+
Sbjct: 938 SDNS--EYSKSEKGKNKEKDRELDK-KEKSRDKE 968
Score = 64.7 bits (156), Expect = 8e-10
Identities = 119/563 (21%), Positives = 210/563 (37%), Gaps = 117/563 (20%)
Query: 824 KERYREWERKYREWYEKYYKGYAAGAQPRPSANREN-FSPERFLPLNIRNSPFTRGRRED 882
KER +E +K E ++ YK + + + S + F E F F ED
Sbjct: 658 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF---------FKSDETED 708
Query: 883 YVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKG 942
H S + EK S + N KD+ +KEK K K+ R + K
Sbjct: 709 LFLNMEHESLTL-----EKKSKLE-KNIKDDKSTKEKHVS------KERNFKEERDKIK- 755
Query: 943 EESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVS 1002
+ESE E ++ ++ RE +++ + + + +++ + + + I +
Sbjct: 756 KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH---LVEKEIDIEKQE 812
Query: 1003 EKDKRERDKPKAKG---DKTKRKNDGSAVSKKENIVKPAKGPQEK------VDGERERSP 1053
+ K ++KP+ + +K K + K++ I K ++K VD +E+
Sbjct: 813 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 872
Query: 1054 RSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKD 1113
+K +E K+ NT + + EK + K ++H + KP KE + +
Sbjct: 873 LYSHHTEKCHKEGEKSKNTAAIKKTDDREK-------SREKMDRKHDKEKPEKERHLAES 925
Query: 1114 YSKDV--KSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK--------TEEKGVDKDFESS 1163
K + K K + E +K KNK D + +K+++ T K + ++ +SS
Sbjct: 926 KEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSS 985
Query: 1164 SMKISK------LEVTEIVKPSP--------KRKMEPDTEK-MDRTPEKDKISLSAPAKK 1208
+ +K L + E K P K K + D ++ +R KDKI +++
Sbjct: 986 IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS---L 1042
Query: 1209 IKLNRETGKKIGSTENISNTKEPSEK------LESTS--------------------SKV 1242
+KL E K + S P EK L TS K+
Sbjct: 1043 LKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKI 1102
Query: 1243 KQE-------------KVKGKVRRKVTGTEGSSSTLVDYTSTSSTGG--------SPVRK 1281
KQ+ K+K K + K T TE + L S+ T V
Sbjct: 1103 KQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSN 1162
Query: 1282 SEEKTDTKRTVIKTMEEYNNDNT 1304
+ DTK + + +DN+
Sbjct: 1163 RSQSVDTKNVMTLGKSSFVSDNS 1185
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 98.2 bits (243), Expect = 6e-20
Identities = 198/910 (21%), Positives = 342/910 (37%), Gaps = 122/910 (13%)
Query: 916 SKEKESENAPGDGKGNKHKKHRKRR-KGEESEGFLNPELLETSRKSREPTGVEENKTDSL 974
SK +E NA + NK KK RK+ KG E + +S E + E+ DSL
Sbjct: 437 SKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSL 496
Query: 975 FVLPSRDDATPVRDEPMDAESITFKSVSE--KDKRERDKPKAKGDKTK--RKNDGSAVSK 1030
+ V +P S++ S S ++ P TK R ++ +S
Sbjct: 497 GSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISS 556
Query: 1031 K--ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1088
+ + + ++ E + S ++ K + ++ K +S S+K +
Sbjct: 557 PAWSEVSSLSDSTRTRLTSESDYSSEGSS-VESLKPVRKRQEHRKRASLSEKKSPFLSSA 615
Query: 1089 RKAHSKSAKEHQETKPVK-------EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLD 1141
A K KE + K K +EK + S+++K + T + E +K+ ++K L+
Sbjct: 616 EGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLE 675
Query: 1142 NKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDK-I 1200
N + K + D+D K+SK+++ E K + D + + R + +K I
Sbjct: 676 ND-LSTENKLKVLKHDRDHFKKEEKLSKMKLEE------KEWLFKDEKSLKRIKDTNKDI 728
Query: 1201 SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1260
S S +K + N+ E + KE S K E ++ +E+ K K + + + E
Sbjct: 729 SRSFREEKDRSNK--------AEKERSLKEKSPKEEKL--RLYKEERKKKSKDRPSKLEK 778
Query: 1261 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK 1320
+ D S K + K + +EY N N
Sbjct: 779 KNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQF--------------- 823
Query: 1321 WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEK-IQKFTKD 1379
+ +D + D + + S + + K + S + Y + +S+ K I + K+
Sbjct: 824 LENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKE 883
Query: 1380 VSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGN 1439
S E + K + KDRDY L+K N EKRK T+ K
Sbjct: 884 DSKERRRDSRAREKRDYREPFFRKKDRDY--LDK-NSEKRKEQTEKHKSVP--------- 931
Query: 1440 FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD 1499
LS+ K+ R S + R + + RD + +K + E +
Sbjct: 932 -GYLSEKDKKRRESAEAGRDRKDALESCKERRDGR----------AKPEEAHREELKECG 980
Query: 1500 SPSRNKDSASGQKNKPRE--ERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1557
S KD + G K E ER P + K+ P ++RK Y K +++
Sbjct: 981 CESGFKDKSDGDFGKGLEPWERHHPAR----EKEKKDGPDKERKEKTKPERYKEKSSDKD 1036
Query: 1558 T--KSVDKNPCKDRE--KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1613
KS+ + KD+E K E ++ KE +T + ++ +D+ K
Sbjct: 1037 KSEKSILEKCQKDKEFDKCFKEKKDTKEKH----------KDTHGKDKERKASLDQG--K 1084
Query: 1614 PKPQLSHSSRLSSDLTRETDE----------AAFEPDYNESDSESNVS--VKEEESSGNI 1661
K + + +S D + + D+ A D +E D +S + K E+S
Sbjct: 1085 EKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLP 1144
Query: 1662 SKD-LKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS 1720
D L++K E+ +E+ S SS P R R +A +
Sbjct: 1145 RTDGLQEK--EEGREAY---------ASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADA 1193
Query: 1721 AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKK----NKDK 1776
+ K +K KEKK + +K+K K A + +K K K +K KK +K K
Sbjct: 1194 GRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAK 1253
Query: 1777 EKEKEKDDQK 1786
K KEK D++
Sbjct: 1254 SKHKEKSDKE 1263
Score = 87.4 bits (215), Expect = 1e-16
Identities = 221/1161 (19%), Positives = 419/1161 (36%), Gaps = 142/1161 (12%)
Query: 696 SRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHR 755
S +++ S S STR+R S S S S P +R + R S +S
Sbjct: 555 SSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSS 614
Query: 756 SRSRSPPYRRYHS---RSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYY 812
+ P + + ++ + + + ++ Q + + Y + D
Sbjct: 615 AEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILL 674
Query: 813 GRSVDF----------RDPFEKE-RYREWERKYREWYEKYYKGYAAGAQPRPSANRE-NF 860
+ RD F+KE + + + + +EW K K +R
Sbjct: 675 ENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFRE 734
Query: 861 SPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKE 920
+R S + +E+ + + + P KL ++ + K++ SKEKE
Sbjct: 735 EKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN--DLKEDKISKEKE 792
Query: 921 SENAPGDGKGNKHKKHRKRRKGEE---SEGFLNPELLETSRKSREPTGVEENKTDSLFVL 977
K K K +R+ +E FL E + S + + +DS F
Sbjct: 793 KIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDF 852
Query: 978 PSRDD----ATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKEN 1033
D T RD D+ + ++D +ER + +K + ++
Sbjct: 853 KGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDY 912
Query: 1034 IVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKI-TGTPRKAH 1092
+ K ++ +E+ + + KK +E + K + S K+ + P +AH
Sbjct: 913 LDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAH 972
Query: 1093 SKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRK-RKT 1151
+ KE K+ K D+ K ++ + + A++ +K+ P + EK K +
Sbjct: 973 REELKECGCESGFKD-KSDGDFGKGLEPWE---RHHPAREKEKKDGPDKERKEKTKPERY 1028
Query: 1152 EEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKL 1211
+EK DKD S+ EK + E DK K K
Sbjct: 1029 KEKSSDKDKSEKSI----------------------LEKCQKDKEFDKCFKEKKDTKEKH 1066
Query: 1212 NRETGKKIGSTENISNTKEPSEK----LESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVD 1267
GK ++ KE EK + S K++ KGK + + + D
Sbjct: 1067 KDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDD 1126
Query: 1268 YTSTSSTGGSPVRKSE-EKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDF 1326
S +G S+ +TD + + E Y +D + D Q P+ + DK
Sbjct: 1127 RDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDK----QHPERQKDK--- 1179
Query: 1327 ESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD-VSHEII 1385
E D + + + G+ K K+ EK+ + S + K KD S +
Sbjct: 1180 --EPRDRRKDRGAADAGR--------DKKEKVFEKHKEKKDKESTEKYKDRKDRASVDST 1229
Query: 1386 QHEV-------KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQG 1438
Q + K+ K A+ +K K+K ++ S +KE+ ++RK+S + E +L
Sbjct: 1230 QDKKNKQKLPEKAEKKHAAEDKAKSKHKEKS--DKEHSKERKSSRSADAEKSL------- 1280
Query: 1439 NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDK------------KTDYDTREYSSSK 1486
+ L + + D +D S+ FT + + D + S+
Sbjct: 1281 -LEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESAC 1339
Query: 1487 RRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT----GDSKKSNSSPSRDRKP 1542
++ E R + S S +K S ++ K +E+ + +KG G S+K + +D
Sbjct: 1340 LPEKLKEKERHRHSSSSSKKSHDRERAK-KEKAEKKEKGEDYKEGGSRKDSGQYEKDFLE 1398
Query: 1543 HD-HKATYDTKRPNEET--KSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVE 1599
D + +Y+ K E+ K+++ + ++K+ E +K+ K L +
Sbjct: 1399 ADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIE--KELKPYGSSAINIL 1456
Query: 1600 KEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSG 1659
KE+ + + + + + L DE E + ++++S
Sbjct: 1457 KEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELL-----RHHRDEQKPATRDKDSPP 1511
Query: 1660 NISKDLKDKIVE--------KAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQT 1711
+ LKDK + K KE A + G S+ + V+PS+ ++
Sbjct: 1512 RV---LKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARP 1568
Query: 1712 RSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSK 1771
R ++ +K+ + ++HK+HK+ K + +K +H +S
Sbjct: 1569 REKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMK---------QMEKLRH---RSG 1616
Query: 1772 KNKDKEKEKEKDDQKVKSVTV 1792
K KEK K DD + K + +
Sbjct: 1617 DPKLKEKAKPADDGRKKGLDI 1637
Score = 82.8 bits (203), Expect = 3e-15
Identities = 166/839 (19%), Positives = 303/839 (36%), Gaps = 126/839 (15%)
Query: 1016 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSS 1075
G T ++ S+ E P+ P VDG S + KAK P
Sbjct: 285 GKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEP-------- 336
Query: 1076 SSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEK--VKKDYSKDVKSEKLTTKEEKAKKP 1133
+K T + + + Q+ P ++K +KKDY K+ KS + + K
Sbjct: 337 ------QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKS 390
Query: 1134 NEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKIS-----KLEVTEIVKPSPKRKMEPDT 1188
KN + K + ++ D E +S+ + +L I+ S R+
Sbjct: 391 YTKNNTIAPKKASHRILSD----TSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAK 446
Query: 1189 EKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVK 1248
++ ++ K K ++++ + + K S+E+ S + E E + S +K
Sbjct: 447 QQKEKNKVKKKRKKETKGREVRFGKRS-DKFCSSESESESSESGE--DDRDSLGSSGCLK 503
Query: 1249 GKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAE 1308
G + + S + + +STSS G S +K + T + + ++
Sbjct: 504 GS---PLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWS 560
Query: 1309 DVIIMIQVPQSK-WDKDDFESEEEDVKSTQP---------------------------IS 1340
+V + +++ + D+ SE V+S +P +
Sbjct: 561 EVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVP 620
Query: 1341 SVGKPASVIKNVSTKPSNIVKYP------------------EKESEPSEKIQKFTKDVSH 1382
+ K V+K TK + K E + S+K D+S
Sbjct: 621 KLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLST 680
Query: 1383 E----IIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKES---NLDRLN 1435
E +++H+ K K K +++++ ++++ ++ K++ + S DR N
Sbjct: 681 ENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSN 740
Query: 1436 EQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELT 1495
+ +SL + S + + R +KD +KK D + S K + K +
Sbjct: 741 KAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKE 800
Query: 1496 RRKDSPSRNKDSASGQ---KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHD-HKATYDT 1551
+ K +DSA + KN+ E D+K S S RDR D +++D
Sbjct: 801 KLKKEKVYREDSAFDEYCNKNQFLENE--------DTKFSLSDDQRDRWFSDLSDSSFDF 852
Query: 1552 KRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKST 1611
K + + V + R+ K S KL+ +++ + + +
Sbjct: 853 KGED------------SWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDY 900
Query: 1612 VKP---KPQLSHSSRLSSDLTRETDEAAFEPDY-NESDSESNVSVKEEESSGNISKDLKD 1667
+P K + + S +T++ P Y +E D K+ S +D KD
Sbjct: 901 REPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKD-------KKRRESAEAGRDRKD 953
Query: 1668 KIVEKAKESLDTAAVVQVGISRNQSH---SSPSVSPSRSHSPSGSQTRSHSSSASSAESQ 1724
+ E KE D A + S S G + A E +
Sbjct: 954 AL-ESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKK 1012
Query: 1725 DSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1783
D K++KEK K +++K+ K + + LEK QK K K K+ KD KEK KD
Sbjct: 1013 DG-PDKERKEKTKPERYKEKSSDKDKSEKSI-LEKCQKDKEFDKCFKEKKD-TKEKHKD 1068
Score = 57.8 bits (138), Expect = 9e-08
Identities = 132/660 (20%), Positives = 237/660 (35%), Gaps = 91/660 (13%)
Query: 634 PPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGS 693
P R+E + +R KE+ K K ++ + ++ E+ K KE++ + + K +
Sbjct: 1015 PDKERKEKTKPER-YKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKD 1073
Query: 694 SYSRSSYTYSKSRSGSTRSRSYSRSFS--RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSH 751
++S K + S FS + + +S +S + R
Sbjct: 1074 KERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGS 1133
Query: 752 GYHRSR-SRSPPYRRYHSRSRSPQAF---RGQSPNKRNVPQGETEREYFNRYREVPPPYD 807
G+ S P + +A+ R + + + P+ + ++E P D
Sbjct: 1134 GFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKE----------PRD 1183
Query: 808 MKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLP 867
+ G + RD EK + E+K +E EKY
Sbjct: 1184 RRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKD------------------------ 1219
Query: 868 LNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGD 927
R+D S + + PEK A H +D KSK KE +
Sbjct: 1220 ------------RKDRASVDSTQDKKNKQKLPEK--AEKKHAAEDKAKSKHKEKSD---- 1261
Query: 928 GKGNKHKKHRKRRKGEESEGFLNPELLETS-RKSREPTG--VEENKTDSLFVLPSRDDAT 984
+H K RK + ++E L +L E + + RE + + E +DS T
Sbjct: 1262 ---KEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLT 1318
Query: 985 PVRD----EPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKG 1040
+ EP + + + +E+++ + +K+ +D +KKE K KG
Sbjct: 1319 AFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRER-AKKEKAEKKEKG 1377
Query: 1041 PQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQ 1100
K G R+ S + E +A + + N K+ + D+ I + K+ E +
Sbjct: 1378 EDYKEGGSRKDSGQYEKDFLEA-DAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSERE 1436
Query: 1101 ETKPV-KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGE----------KRKR 1149
+K + KE K + ++ EK ++ + K +EK + D + R
Sbjct: 1437 PSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHH 1496
Query: 1150 KTEEKGVDKDFESSSMKI---SKLEVTEIVKPSPKRKMEPDTEKMDRTPEK-----DKIS 1201
+ E+K +D +S + S+ E + K K + EK P K DK++
Sbjct: 1497 RDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVA 1556
Query: 1202 LSA-PAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1260
S P KK RE G S + S+K + K+ K + K K+ G
Sbjct: 1557 PSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSG 1616
Score = 55.5 bits (132), Expect = 5e-07
Identities = 97/394 (24%), Positives = 155/394 (39%), Gaps = 71/394 (18%)
Query: 1448 KEARTSDKHDSTRASSNKD---FTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRN 1504
K TS + ST +S +D F P+ + E+ + KN ++ +P ++
Sbjct: 286 KGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKD 345
Query: 1505 K----DSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1560
+ + + P +++ L KK KSNS S P E KS
Sbjct: 346 EYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISI---------------PKMEVKS 390
Query: 1561 VDKN----PCKDREKHVLEARNNKESS-----GNKL---LYILNPPETQVEKEQITGQID 1608
KN P K + + + + +++S G KL + + P E Q +
Sbjct: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKE 450
Query: 1609 KSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDK 1668
K+ VK K + R + +D+ +ES+SES+ S +++ S S LK
Sbjct: 451 KNKVKKKRKKETKGR-EVRFGKRSDKFCS----SESESESSESGEDDRDSLGSSGCLKGS 505
Query: 1669 -IVEKAKE---SLDTAAVVQVGIS----RNQSH----------------SSPSVSPSRSH 1704
+V K SL ++ G S +N SH SSP+ S S
Sbjct: 506 PLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSL 565
Query: 1705 SPSGSQTR-----SHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1759
S S ++TR +SS SS ES +K+++ K+ KK G +L+K
Sbjct: 566 SDS-TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDK 624
Query: 1760 SQK--HKHKKKKSKKNKDKEKEKEKDDQKVKSVT 1791
K KHK K KNK+K + + K+KS T
Sbjct: 625 EGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFT 658
Score = 34.7 bits (78), Expect = 0.86
Identities = 87/439 (19%), Positives = 165/439 (37%), Gaps = 40/439 (9%)
Query: 1379 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQP--EKESNLDRLNE 1436
D E+ + K + G+ KD D EK+ PE+++ +P K L +
Sbjct: 46 DGGKEVRERASKRKLPFTAGANGEQKDSD---TEKQGPERKRIKKEPVTRKAGLLFGMGL 102
Query: 1437 QGNFKS--LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTR--EYSSSKRRDEKN 1492
G LS+ + A A+S D TP ++ + S+SK +D+ N
Sbjct: 103 SGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVN 162
Query: 1493 ELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTK 1552
+ R ++ + + + R ++L +G + K + + + ++ YD
Sbjct: 163 KRNERGET----RLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEA-CNRGYYDVA 217
Query: 1553 RPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLL--YILNPPETQVEKEQITGQIDKS 1610
+ + D + + +A NN KLL Y NP ++ + E +
Sbjct: 218 KQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSP 277
Query: 1611 T----VKPKPQLSHSSRLSSDLTRETDEAAFEP----DYNESDSESNVSVKEEESSGNIS 1662
T + K + S S++ + E D +F P D N +DSE +K + +
Sbjct: 278 TMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQ 337
Query: 1663 K---DLKDKIVEKAKESLDTAAVVQ-----VGISRNQSHSSPSVSPSRSHSPSGSQTR-- 1712
K +KD+ + D V R ++ S+ +S + S ++
Sbjct: 338 KATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTI 397
Query: 1713 -----SHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKK 1767
SH + +++ +D+ EK + H K + + +K +K+K KK
Sbjct: 398 APKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQK-EKNKVKK 456
Query: 1768 KKSKKNKDKEKEKEKDDQK 1786
K+ K+ K +E K K
Sbjct: 457 KRKKETKGREVRFGKRSDK 475
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 97.8 bits (242), Expect = 8e-20
Identities = 131/637 (20%), Positives = 257/637 (40%), Gaps = 107/637 (16%)
Query: 1050 ERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEK 1109
E P+S+ +KK +++ K+ ++ SSSSS D + S+S+ + +++ EEK
Sbjct: 176 ELIPKSK--VKKEEKKRHKSSSSSSSSSSDSDSS-------SDSQSSSDSSDSESATEEK 226
Query: 1110 VKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISK 1169
KK K K+ + KE+K +K ++K+ +++ E + + + ++
Sbjct: 227 SKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIP----- 281
Query: 1170 LEVTEIVKPSPKRKMEPDTEKMDRTPEKD---KISLSAPAKKIKLNRETGKKIGS----- 1221
E +++ SP + E + + +R E++ S A ++ L +G+KI
Sbjct: 282 -ENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRR 340
Query: 1222 --TENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPV 1279
T + S +++ + E T +QE + + R +G + SPV
Sbjct: 341 YRTPSRSRSRDRFRRSE-TPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPV 399
Query: 1280 RKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPI 1339
R E K R V +S K++ E + +D KS
Sbjct: 400 RVKERKITDHR------------------------NVSESPNRKNEKEKKVKDHKS---- 431
Query: 1340 SSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSE 1399
++K +I + EK+ + K++K KS S S E
Sbjct: 432 -------------NSKERDIRRNSEKDDKYKNKVKK------------RAKSKSRSKSKE 466
Query: 1400 KGKTKDRDYSVLEKENPEKR----------KNSTQPEKESNLDRLNEQGNFKSLSQSSKE 1449
K K+K+RD N EKR +N + EK+S+ + +Q +S +S +
Sbjct: 467 KSKSKERDSK--HNRNEEKRMRSRSKGRDHENVKEKEKQSD-SKGKDQERSRSKEKSKQL 523
Query: 1450 ARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR---RDEKNELTRRKDSPSRNKD 1506
S++HD +++ +R ++ D ++S + R R + +RR S + ++D
Sbjct: 524 ESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRD 583
Query: 1507 SASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPC 1566
+ ++ E++ ++G S++ + P R R + D+ R +E +S +N
Sbjct: 584 RSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDS-RSSEREESQSRNKD 642
Query: 1567 KDREKHVLEARNNKESSGNKLLYIL----NPPETQVEKEQITGQIDKSTVKPKPQLSHSS 1622
K R + + + S K +Y N EK+ Q S +K Q S +
Sbjct: 643 KYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIK---QSSQDN 699
Query: 1623 RLSSDLTRETDE----AAFEPDYNESDSESNVSVKEE 1655
L S + + ++ ++ E + +S + N V E+
Sbjct: 700 ELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEK 736
Score = 80.9 bits (198), Expect = 1e-14
Identities = 129/617 (20%), Positives = 227/617 (36%), Gaps = 88/617 (14%)
Query: 891 SRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGK-----GNKHKKHRKRRKGEES 945
S + S+ + S+ D + D++ S+ E + K KHKK +K+RK +
Sbjct: 194 SSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKK 253
Query: 946 EGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKD 1005
E + + EE + P ++ +R P A+ K+ +
Sbjct: 254 SASSESEAENLEAQPQSTVRPEE-------IPPIPENRFLMRKSPPKADEKERKNRERER 306
Query: 1006 KRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1065
+RE + P ++ +R+ + +K P + R+R RSE P ++E
Sbjct: 307 ERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETP-PHWRQE 365
Query: 1066 TPKTDNTKSSSSSQ--KDEKITGTPRKAHSKSAKEHQETKPVKEEKV------KKDYSKD 1117
+ + SS + K +K K + +S +E K V K + K
Sbjct: 366 MQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKK 425
Query: 1118 VKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVK 1177
VK K +KE ++ +EK+ NK +KR K++ + K+ S + SK E
Sbjct: 426 VKDHKSNSKERDIRRNSEKDDKYKNKVKKR-AKSKSRSKSKEKSKSKERDSKHNRNE--- 481
Query: 1178 PSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLES 1237
+++M ++ D K+K +++ K G + S +KE S++LES
Sbjct: 482 ---EKRMRSRSKGRDHENVKEK------------EKQSDSK-GKDQERSRSKEKSKQLES 525
Query: 1238 TSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTM- 1296
S++ K K K RR S S D T + S R+ D R V
Sbjct: 526 KSNEHDHSKSKEKDRR-----AQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580
Query: 1297 ---------------EEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISS 1341
+EY + + + + P + D D +S++ S
Sbjct: 581 DRDRSRSKEYHRYREQEYRRRGRSRSRE----RRTPPGRSRSKDRRRRRRDSRSSEREES 636
Query: 1342 VGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKG 1401
+ +N +K S+ KE+ SEK + ++K H NS+++ +
Sbjct: 637 QSRNKDKYRNQESKSSH-----RKENSESEK-RMYSKSRDH-----------NSSNNSRE 679
Query: 1402 KTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRA 1461
K DRD S K + N + N + + + + +Q SK H+
Sbjct: 680 KKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHE---- 735
Query: 1462 SSNKDFTPNRDKKTDYD 1478
NK F TD D
Sbjct: 736 -KNKKFDHESSPGTDED 751
Score = 80.1 bits (196), Expect = 2e-14
Identities = 122/581 (20%), Positives = 215/581 (37%), Gaps = 76/581 (13%)
Query: 1240 SKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEY 1299
SKVK+E+ K R K + + SSS+ D +S+ S S SE T+ K K
Sbjct: 181 SKVKKEEKK---RHKSSSSSSSSSSDSD-SSSDSQSSSDSSDSESATEEKSKKRKKKHRK 236
Query: 1300 NNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNI 1359
N+ + + K K E + QP S+V +P I
Sbjct: 237 NSRKHKKEKK-------KRKKSKKSASSESEAENLEAQPQSTV------------RPEEI 277
Query: 1360 VKYPEKE----SEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKEN 1415
PE P + +K K+ E + + AS ++ R ++
Sbjct: 278 PPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRG 337
Query: 1416 PEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTS--------DKHDSTRASSNKDF 1467
P + + ++ R +++ Q ++ R S DK + N+
Sbjct: 338 PRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRS 397
Query: 1468 TPNRDKKTDYDTREYSSS-KRRDEKNELTRRKDSPSRNKD----SASGQKNKPREERDLP 1522
++ D R S S R++EK + + S S+ +D S K K + ++
Sbjct: 398 PVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAK 457
Query: 1523 KKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKES 1582
K SK+ + S RD K + + + KR +K D K++EK ++E
Sbjct: 458 SKSRSKSKEKSKSKERDSKHNRN----EEKRMRSRSKGRDHENVKEKEKQSDSKGKDQER 513
Query: 1583 SGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYN 1642
S +K E + E + + D S K K + + S D+T+ + YN
Sbjct: 514 SRSK--------EKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKG------KHSYN 559
Query: 1643 ESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSR 1702
E + S + + D +D+ K + G SR++ +P P R
Sbjct: 560 SRTRERSRSRDRSRRVRSRTHD-RDRSRSKEYHRYREQEYRRRGRSRSRERRTP---PGR 615
Query: 1703 SHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQK 1762
S S + R S S+ ESQ K K + ++ K K++ + +K ++ S
Sbjct: 616 SRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSN 675
Query: 1763 HKHKKKKSK--------KNKDKEKE------KEKDDQKVKS 1789
+ +KK + K ++ E K K+D+K++S
Sbjct: 676 NSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRS 716
Score = 76.6 bits (187), Expect = 2e-13
Identities = 127/618 (20%), Positives = 232/618 (37%), Gaps = 129/618 (20%)
Query: 652 EKKKSKLDEFTNDFAK-------ELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSK 704
E + K D + FA+ EL+ K++KE ++ R KS S SS S S + S
Sbjct: 153 EIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKK---RHKSSSSSSSSSSDSDSSSD 209
Query: 705 SRSGSTRSRSYS-------------RSFSRSHSRSYSRS--------------------- 730
S+S S S S S R SR H + +
Sbjct: 210 SQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQ 269
Query: 731 --------PPYPR----------RGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRS 772
PP P + K R R R R + S+ Y+R +RS
Sbjct: 270 STVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRS 329
Query: 773 PQAFRGQSPNKRNVPQGETEREYFNRYREVPPPY--------DMKAYYGRSVDFRDPFEK 824
+ +G+ P + P R+ F R E PP + M+ G D E
Sbjct: 330 GRKIKGRGPRRYRTPSRSRSRDRFRR-SETPPHWRQEMQRAQRMRVSSGERWIKGDKSEL 388
Query: 825 ERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYV 884
+E +R E+ + ++ S NR+N E+ + + NS +E +
Sbjct: 389 NEIKENQRSPVRVKERKITDHRNVSE---SPNRKN-EKEKKVKDHKSNS------KERDI 438
Query: 885 GGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEE 944
S + + ++ ++ K+ +KSKE++S++ N+ K+ R R KG +
Sbjct: 439 RRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKH-----NRNEEKRMRSRSKGRD 493
Query: 945 SEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEK 1004
E E S+ + + K+ L + D + +++ A+S + + K
Sbjct: 494 HENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITK 553
Query: 1005 DK-------RERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEP 1057
K RER + + + + + + S+ + + + + R R R+ P
Sbjct: 554 GKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPP 613
Query: 1058 PIKKAKEETPKTDNTKSSSSSQ---------KDEKITGTPRKAHSKSAK-------EHQE 1101
++K+ + +++SS + ++++ + RK +S+S K +H
Sbjct: 614 GRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNS 673
Query: 1102 TKPVKEEKVKKDYS-----------KDVKSEKLTTKEEK-----AKKPNEKNKPLDNK-- 1143
+ +E+K +D S ++KS L KE++ +K N+K+K +N
Sbjct: 674 SNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHV 733
Query: 1144 GEKRKRKTEEK--GVDKD 1159
EK K+ E G D+D
Sbjct: 734 HEKNKKFDHESSPGTDED 751
Score = 71.6 bits (174), Expect = 6e-12
Identities = 84/445 (18%), Positives = 170/445 (38%), Gaps = 62/445 (13%)
Query: 1376 FTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLN 1435
F + +S + + E+++ K A+S K + R S E K K + +S+ +
Sbjct: 141 FGQVISGQEVVREIENQKTDAAS-KPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSS 199
Query: 1436 EQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELT 1495
+ S S S + +SD +T S K R KK ++R++ K++ +K++ +
Sbjct: 200 SSSDSDSSSDSQSSSDSSDSESATEEKSKK-----RKKKHRKNSRKHKKEKKKRKKSKKS 254
Query: 1496 RRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPN 1555
+S + N ++ +P E +P+ K + ++RK + + + PN
Sbjct: 255 ASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPN 314
Query: 1556 EETKSVDKNPCKDREKHVLEARN-------NKESSGNKLLYILNPPETQVEKEQ------ 1602
+ S + R ++ R ++ S ++ PP + E ++
Sbjct: 315 SQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRV 374
Query: 1603 ------ITG---------QIDKSTVKPKPQ-LSHSSRLSSDLTRETDEAAFEPDYNESDS 1646
I G + +S V+ K + ++ +S R+ ++ D+ +
Sbjct: 375 SSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSK 434
Query: 1647 ESNV---SVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1703
E ++ S K+++ + K K K K+KE S+++ S
Sbjct: 435 ERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEK-----------SKSKERDSKHNRNEEK 483
Query: 1704 HSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKH 1763
S S+ R H + + DSK K +++ + K K + K S +H
Sbjct: 484 RMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESK-------------SNEH 530
Query: 1764 KHKKKKSKKNKDKEKEKEKDDQKVK 1788
H K K K + + + +E D K K
Sbjct: 531 DHSKSKEKDRRAQSRSRECDITKGK 555
Score = 59.3 bits (142), Expect = 3e-08
Identities = 84/363 (23%), Positives = 141/363 (38%), Gaps = 50/363 (13%)
Query: 626 NTIPTTQAPPLS-REEFYREQRRLKEE-----EKKKSKLDEFTNDFAKELM-------EY 672
N I Q P+ +E + R + E EK+K D +N +++ +Y
Sbjct: 389 NEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKY 448
Query: 673 KKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSR---SFSRSHSRSYSR 729
K K+R +S SRSKS S R S ++++ RSRS R + +S S+
Sbjct: 449 KNKVKKRAKSKSRSKSKEKSKSKERDS-KHNRNEEKRMRSRSKGRDHENVKEKEKQSDSK 507
Query: 730 SPPYPR-RGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSP------- 781
R R + KS+ S+S H + +S+ + RR SRSR +G+
Sbjct: 508 GKDQERSRSKEKSKQLESKSNEHDHSKSKEKD---RRAQSRSRECDITKGKHSYNSRTRE 564
Query: 782 -----------NKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREW 830
R + + + ++RYRE Y + RS + R P + R ++
Sbjct: 565 RSRSRDRSRRVRSRTHDRDRSRSKEYHRYRE--QEYRRRG-RSRSRERRTPPGRSRSKDR 621
Query: 831 ERK-------YREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDY 883
R+ RE + K + + S +EN E+ + R+ + RE
Sbjct: 622 RRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKK 681
Query: 884 VG-GQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKG 942
QS S+ S+ +L + N++D E EN G+ N H + ++
Sbjct: 682 ADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFD 741
Query: 943 EES 945
ES
Sbjct: 742 HES 744
Score = 54.3 bits (129), Expect = 1e-06
Identities = 97/484 (20%), Positives = 168/484 (34%), Gaps = 97/484 (20%)
Query: 631 TQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPY 690
++ PP R+E R QR ++ K D+ EL E K+ Q+ R R + +
Sbjct: 356 SETPPHWRQEMQRAQRMRVSSGERWIKGDK------SELNEIKENQRSPVRVKERKITDH 409
Query: 691 SGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRS 750
S S + + + +S S R R+ + +R + KSR+ +S+ +S
Sbjct: 410 RNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRS-KSKEKS 468
Query: 751 HGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKA 810
R + R R RS R + + NV + E + +
Sbjct: 469 KSKERDSKHN---RNEEKRMRS----RSKGRDHENVKEKEKQSD---------------- 505
Query: 811 YYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNI 870
+ D KE+ ++ E K E K AQ R
Sbjct: 506 --SKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRS----------------- 546
Query: 871 RNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKG 930
R T+G+ + R+R + R + +D ++SKE
Sbjct: 547 RECDITKGKH-----SYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEY----------- 590
Query: 931 NKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEP 990
+++++ RR+G SR+ R P G +K RD + R+E
Sbjct: 591 HRYREQEYRRRGR-----------SRSRERRTPPGRSRSKDRR---RRRRDSRSSEREES 636
Query: 991 MDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERE 1050
KDK + K+ K +++ SK + ++K D
Sbjct: 637 QS---------RNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKAD---- 683
Query: 1051 RSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKV 1110
R + P K K+ + + S +++DEKI + K + KS + QE V E+
Sbjct: 684 ---RDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKS--KGQENDHVHEKNK 738
Query: 1111 KKDY 1114
K D+
Sbjct: 739 KFDH 742
Score = 37.0 bits (84), Expect = 0.17
Identities = 35/138 (25%), Positives = 57/138 (41%), Gaps = 36/138 (26%)
Query: 1654 EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRS 1713
E + + SK + + E + + V + R++S SS S S S S S S SQ
Sbjct: 155 ENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQ--- 211
Query: 1714 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773
SS+ S++S+ + ++K KK KKKH K +
Sbjct: 212 --SSSDSSDSESATEEKSKKRKKKH-------------------------------RKNS 238
Query: 1774 KDKEKEKEKDDQKVKSVT 1791
+ +KEK+K + KS +
Sbjct: 239 RKHKKEKKKRKKSKKSAS 256
>gi|167234419 thyroid hormone receptor associated protein 3 [Homo
sapiens]
Length = 955
Score = 97.4 bits (241), Expect = 1e-19
Identities = 208/939 (22%), Positives = 336/939 (35%), Gaps = 193/939 (20%)
Query: 691 SGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRS 750
S ++ S+S S+SRS S RSRS S S SRS SRS SRS R R S RSRS S
Sbjct: 2 SKTNKSKSGSRSSRSRSAS-RSRSRSFSKSRSRSRSLSRS-----RKRRLSSRSRSRSYS 55
Query: 751 HGYHRSRSRSPPYR----RYHSRS-RSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPP 805
++R R+ Y+ R H+R R P FRG+ N+ P G+ R + YR
Sbjct: 56 PAHNRERNHPRVYQNRDFRGHNRGYRRPYYFRGR--NRGFYPWGQYNRGGYGNYRS---- 109
Query: 806 YDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERF 865
W+ YR+ Y PR +R SP+R
Sbjct: 110 -----------------------NWQ-NYRQAY-----------SPRRGRSRSR-SPKRR 133
Query: 866 LPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESEN-- 923
P SP +R + S RSR S+ +R +++ + K K+ S++
Sbjct: 134 SP-----SPRSRSHSRNSDKSSSDRSRRSSSSRSSSNHSRVESSKRKSAKEKKSSSKDSR 188
Query: 924 ---APGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSR 980
A GD +G++ K+ + G S+ + +S +P T S +
Sbjct: 189 PSQAAGDNQGDEAKE--QTFSGGTSQD-------TKASESSKPWPDATYGTGSASRASAV 239
Query: 981 DDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKG 1040
+ +P P + V + R PK + GS +
Sbjct: 240 SELSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPPLSSTSQMGSTLPSGAGYQSGTHQ 299
Query: 1041 PQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGT--------PRKAH 1092
Q G SP + P+ K+ P T +T SS ++ G +K
Sbjct: 300 GQFD-HGSGSLSPSKKSPVGKS---PPSTGSTYGSSQKEESAASGGAAYTKRYLEEQKTE 355
Query: 1093 SKSAKEHQETKPVKEEKVKKDYSKD-------VKSEKLTTKEEKAK----KPNEKNKPLD 1141
+ KE ++T KE+ +K D +KS+ K + K + K L
Sbjct: 356 NGKDKEQKQTNTDKEKIKEKGSFSDTGLGDGKMKSDSFAPKTDSEKPFRGSQSPKRYKLR 415
Query: 1142 NKGEKRK---RKTEEKGVDKDFESSSMKISKLE-----VTEIVKPSPKRKME-------- 1185
+ EK+ K E DKD ++ K S+ + +++++ + ++ E
Sbjct: 416 DDFEKKMADFHKEEMDDQDKD-KAKGRKESEFDDEPKFMSKVIGANKNQEEEKSGKWEGL 474
Query: 1186 ----PDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSK 1241
P EK +T E ++ S +KK + GK+ +E P + T+ K
Sbjct: 475 VYAPPGKEKQRKTEELEEESFPERSKK----EDRGKR---SEGGHRGFVPEKNFRVTAYK 527
Query: 1242 VKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNN 1301
QEK RK + + + G P KS + V M+ ++
Sbjct: 528 AVQEKSSSPPPRKTSESR---------DKLGAKGDFPTGKSSFSITREAQVNVRMDSFDE 578
Query: 1302 DNTAP----AEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPS 1357
D P A++ + + S + +F S + ++S Q
Sbjct: 579 DLARPSGLLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQ-------------------- 618
Query: 1358 NIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPE 1417
+ PSE + + H + +H SS G T ++ K E
Sbjct: 619 -------SQRSPSELFAQHIVTIVHHVKEHHFGSS--------GMTLHERFTKYLKRGTE 663
Query: 1418 KR--KNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKT 1475
+ KN PE +D S S K D+ S R K + K
Sbjct: 664 QEAAKNKKSPEIHRRID--------ISPSTFRKHGLAHDEMKSPREPGYK--AEGKYKDD 713
Query: 1476 DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKK---- 1531
D R +++ ++ +L R K S + +S + + E+ + KG+ KK
Sbjct: 714 PVDLRLDIERRKKHKERDLKRGKSRESVDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRA 773
Query: 1532 ---SNSSPSRDRKPHDHKA---TYDTKRPNEETKSVDKN 1564
S SS S + H +KA T +T+ E T DK+
Sbjct: 774 RDRSRSSSSSSQSSHSYKAEEYTEETEEREESTTGFDKS 812
Score = 77.4 bits (189), Expect = 1e-13
Identities = 151/764 (19%), Positives = 280/764 (36%), Gaps = 116/764 (15%)
Query: 1049 RERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQ--ETKPVK 1106
R RSP+ P +++ + +D + S S R + S+S+ H E+ K
Sbjct: 126 RSRSPKRRSPSPRSRSHSRNSDKSSSDRSR----------RSSSSRSSSNHSRVESSKRK 175
Query: 1107 EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMK 1166
K KK SKD + + DN+G++ K +T G +D ++S
Sbjct: 176 SAKEKKSSSKDSRPSQAAG---------------DNQGDEAKEQTFSGGTSQDTKASESS 220
Query: 1167 ISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK-------- 1218
+ T + + + +R+P +L +P + + + R + +
Sbjct: 221 KPWPDATYGTGSASRASAVSELSPRERSP-----ALKSPLQSVVVRRRSPRPSPVPKPSP 275
Query: 1219 -IGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGS 1277
+ ST + +T +S + + + + G + G S ST ST GS
Sbjct: 276 PLSSTSQMGSTLPSGAGYQSGTHQGQFDHGSGSLSPSKKSPVGKSPP-----STGSTYGS 330
Query: 1278 PVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQ 1337
++ + + +EE +N E Q+ DK E +K
Sbjct: 331 SQKEESAASGGAAYTKRYLEEQKTENGKDKEQ-------KQTNTDK-------EKIKEKG 376
Query: 1338 PISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSAS 1397
S G +K+ S P + P + S+ S K K D ++ + +
Sbjct: 377 SFSDTGLGDGKMKSDSFAPKTDSEKPFRGSQ-SPKRYKLRDDFEKKMADFHKEEMDDQ-- 433
Query: 1398 SEKGKTKDRDYSVLEKENPEKRK----NSTQPEKESNLDRLNEQGNFKSLSQSSKEARTS 1453
+K K K R S + E K N Q E++S G ++ L +
Sbjct: 434 -DKDKAKGRKESEFDDEPKFMSKVIGANKNQEEEKS--------GKWEGLVYAPPG---K 481
Query: 1454 DKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRR-DEKN-ELTRRKDSPSRNKDSASGQ 1511
+K T + F P R KK D R + EKN +T K + + S+S
Sbjct: 482 EKQRKTEELEEESF-PERSKKEDRGKRSEGGHRGFVPEKNFRVTAYK---AVQEKSSSPP 537
Query: 1512 KNKPREERD-LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTK--RPNEETKSVDKNPCKD 1568
K E RD L KG + KS+ S +R+ + + ++D RP+ + ++ C+D
Sbjct: 538 PRKTSESRDKLGAKGDFPTGKSSFSITREAQVNVRMDSFDEDLARPSG-LLAQERKLCRD 596
Query: 1569 REKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSS------ 1622
L N KE + + ++Q ++ Q + V + S
Sbjct: 597 -----LVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLH 651
Query: 1623 -RLSSDLTRETDEAAFE----PDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESL 1677
R + L R T++ A + P+ + S + ++ + + K ++ + +
Sbjct: 652 ERFTKYLKRGTEQEAAKNKKSPEIHRRIDISPSTFRKHGLAHDEMKSPREPGYKAEGKYK 711
Query: 1678 DTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKK 1737
D +++ I R + H + +S S S +S S+++ +K +K
Sbjct: 712 DDPVDLRLDIERRKKHKERDLKRGKSRE-----------SVDSRDSSHSRERSAEKTEKT 760
Query: 1738 HKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKE 1781
HK KK KKH++ S + H K + ++ E+ +E
Sbjct: 761 HKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYTEETEEREE 804
Score = 43.5 bits (101), Expect = 0.002
Identities = 100/479 (20%), Positives = 166/479 (34%), Gaps = 59/479 (12%)
Query: 680 RRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRG 739
RR SRS+SP K RS S RSRS+SR+ +S S R R
Sbjct: 121 RRGRSRSRSP--------------KRRSPSPRSRSHSRNSDKSSS----------DRSR- 155
Query: 740 KSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPN---KRNVPQGETEREYF 796
+S + RS S S+ +S ++ S+ P G + K G T ++
Sbjct: 156 RSSSSRSSSNHSRVESSKRKSAKEKKSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQD-- 213
Query: 797 NRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSAN 856
+ E P+ Y S + RE + + PRPS
Sbjct: 214 TKASESSKPWPDATYGTGSASRASAVSELSPRERSPALKSPLQSV---VVRRRSPRPSPV 270
Query: 857 RENFSPERFLPLNIRNSPFTRGRREDYVGGQ-SHRSRNIGSNYPEKLSARDGHNQKDNTK 915
+ P P G + GQ H S ++ + +
Sbjct: 271 PKPSPPLSSTSQMGSTLPSGAGYQSGTHQGQFDHGSGSLSPSKKSPVGKSPPSTGSTYGS 330
Query: 916 SKEKESENAPGDGKGNKHKKHRKRRKGEESE-GFLNPELLETSRK-SREPTGVEENKTDS 973
S+++ES + G ++ + +K G++ E N + + K S TG+ + K S
Sbjct: 331 SQKEESAASGGAAYTKRYLEEQKTENGKDKEQKQTNTDKEKIKEKGSFSDTGLGDGKMKS 390
Query: 974 LFVLPSRDDATPVRDEP-------MDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGS 1026
P D P R D +++ ++DK KAKG K +D
Sbjct: 391 DSFAPKTDSEKPFRGSQSPKRYKLRDDFEKKMADFHKEEMDDQDKDKAKGRKESEFDDEP 450
Query: 1027 AVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITG 1086
K ++ K +E+ G+ E + P KE+ KT+ + S ++ +K
Sbjct: 451 KFMSK--VIGANKNQEEEKSGKWEGLVYAPP----GKEKQRKTEELEEESFPERSKK--- 501
Query: 1087 TPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGE 1145
+S H+ P K +V K+ + + +K +E L KG+
Sbjct: 502 --EDRGKRSEGGHRGFVPEKNFRVTA-----YKAVQEKSSSPPPRKTSESRDKLGAKGD 553
Score = 37.4 bits (85), Expect = 0.13
Identities = 58/264 (21%), Positives = 99/264 (37%), Gaps = 46/264 (17%)
Query: 670 MEYKKIQKER--RRSFSRSKSPYSGSSYSR--SSYTYSKSRSGSTRSRSYSRSFSRSHSR 725
+E +K KER +R SR SS+SR S+ K+ GS + + + R+ RS S
Sbjct: 721 IERRKKHKERDLKRGKSRESVDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRARDRSRSS 780
Query: 726 SYSRSPPYPRRGRGKSRNYRSRSRSH-GYHRSRSRSP----PYRRYHSRSRSPQAFRGQS 780
S S + + + R S G+ +SR + P R R+R FR +
Sbjct: 781 SSSSQSSHSYKAEEYTEETEEREESTTGFDKSRLGTKDFVGPSERGGGRARGTFQFRARG 840
Query: 781 PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK 840
R +G N DF+ ++ R EW+ +Y +K
Sbjct: 841 ---RGWGRGNYSGNNNNNSNN---------------DFQ---KRNREEEWDPEYTPKSKK 879
Query: 841 YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYP- 899
YY +RE ++++ F RGR G R + +
Sbjct: 880 YYL----------HDDREGEGSDKWVSRGRGRGAFPRGR-----GRFMFRKSSTSPKWAH 924
Query: 900 EKLSARDGHNQKDNTKSKEKESEN 923
+K S +G + D + ++ +E ++
Sbjct: 925 DKFSGEEGEIEDDESGTENREEKD 948
Score = 35.0 bits (79), Expect = 0.66
Identities = 33/127 (25%), Positives = 53/127 (41%), Gaps = 9/127 (7%)
Query: 643 REQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYT- 701
RE ++ + + E T K + KK ++ R RS S S S S SY YT
Sbjct: 738 RESVDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYTE 797
Query: 702 ----YSKSRSGSTRSRSYSRSFSRSHSRSYSRSP---PYPRRGRGKSR-NYRSRSRSHGY 753
+S +G +SR ++ F R R+ + RGRG R NY + ++
Sbjct: 798 ETEEREESTTGFDKSRLGTKDFVGPSERGGGRARGTFQFRARGRGWGRGNYSGNNNNNSN 857
Query: 754 HRSRSRS 760
+ + R+
Sbjct: 858 NDFQKRN 864
Score = 34.7 bits (78), Expect = 0.86
Identities = 24/101 (23%), Positives = 39/101 (38%), Gaps = 18/101 (17%)
Query: 1695 SPSVSPSRSHSPS----GSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKH 1750
SP SRS SP ++RSHS ++ + S S++ + H +
Sbjct: 119 SPRRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSSRSSSNHSR---------- 168
Query: 1751 AGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVT 1791
VE K + K KK SK ++ + + + K T
Sbjct: 169 ----VESSKRKSAKEKKSSSKDSRPSQAAGDNQGDEAKEQT 205
Score = 32.7 bits (73), Expect = 3.3
Identities = 33/119 (27%), Positives = 55/119 (46%), Gaps = 9/119 (7%)
Query: 643 REQRRLKEEEKKKSKLDEFTNDFAKELMEY----KKIQKERRRSFSRSKSPYSGSSYSRS 698
R+ +R K E S+ + + + E E K QK+ RR+ RS+ S SS S+S
Sbjct: 730 RDLKRGKSRESVDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRARDRSR---SSSSSSQS 786
Query: 699 SYTY-SKSRSGSTRSRSYSRS-FSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHR 755
S++Y ++ + T R S + F +S + P R G ++ R+R G+ R
Sbjct: 787 SHSYKAEEYTEETEEREESTTGFDKSRLGTKDFVGPSERGGGRARGTFQFRARGRGWGR 845
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 97.1 bits (240), Expect = 1e-19
Identities = 120/547 (21%), Positives = 210/547 (38%), Gaps = 70/547 (12%)
Query: 1280 RKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMI----------QVPQSKWDKDDFESE 1329
RKS + T K ++ ND + P + I + Q P KW + F
Sbjct: 25 RKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRK- 83
Query: 1330 EEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESE------PSEKIQK------FT 1377
+ PI + + + +++ T +++ K K+S+ P +K K T
Sbjct: 84 ---ILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYAT 140
Query: 1378 KDVSHEIIQ-----------------HEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK 1420
S +I++ HE + SK S SS + + ++ + K +K K
Sbjct: 141 NPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDK 200
Query: 1421 NSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFT----PNRDKKTD 1476
++ K++N + L+ + N K + SK + + S N DF + D+ +
Sbjct: 201 KDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESIN 260
Query: 1477 YDT--REYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNS 1534
+D R YS + ++ + T+ KD+ K E + K DSKK
Sbjct: 261 FDAWLRNYSQNNSKNYSLKYTKYT-----KKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
Query: 1535 SPSRDRKPHD-HKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNP 1593
+ +D K D K T T + ++K K+ KD++K +++K+ K P
Sbjct: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKL---KKDDKKKDTKKY-----P 367
Query: 1594 PETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
T E K L +S+ + D ++ + F D +ES+ ES S K
Sbjct: 368 ESTDTESGDA-----KDARNDSRNLKKASK-NDDKKKDAKKITFSTD-SESELESKESQK 420
Query: 1654 EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRS 1713
+E+ SK K V+ +ES D + + + + S+ ++
Sbjct: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
Query: 1714 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773
S+ ++ + K KK KEKK KK K K T+ E ++S K K K
Sbjct: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
Query: 1774 KDKEKEK 1780
D E E+
Sbjct: 541 SDTESEE 547
Score = 70.9 bits (172), Expect = 1e-11
Identities = 89/396 (22%), Positives = 150/396 (37%), Gaps = 77/396 (19%)
Query: 1459 TRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREE 1518
T A F KT EY SK DEK +KDS + A+ ++K E
Sbjct: 92 TAAREQTPFRHLYTSKTHLKKAEYKKSK--DEKGGTPLKKDSKKKGGSYATNPESKQIVE 149
Query: 1519 RDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARN 1578
++ D SS ++ K++ +T ++ +K+V KN C ++K +++N
Sbjct: 150 EKTKRQNEADKTPLKSSHENEQSKKS-KSSSETNPESQNSKTVSKN-CSQKDKK--DSKN 205
Query: 1579 NKESSGNKLLYILNPPETQVEKEQ---------------------ITGQID--------- 1608
+K+++ + L+ N P+ +++ + + GQ D
Sbjct: 206 SKKTN-TEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAW 264
Query: 1609 --------------KSTVKPKPQLSHSSRLSSDLTRETDEAA------------------ 1636
K T K +++ SSD E + A
Sbjct: 265 LRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKK 324
Query: 1637 -FEPDYNESDSESNVSVKEEESSGN----ISKDLKDKIVEKAKESLDTAAVVQVGISRNQ 1691
+ D +D+ES S E + + + KD K K +K ES DT + +RN
Sbjct: 325 DVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG-DAKDARND 383
Query: 1692 SHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHA 1751
S + S + + + S S ES++S+K +KK +KK K K
Sbjct: 384 SRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK-DKKDSKTDNKKSVKNDEE 442
Query: 1752 GTEVELE-KSQKHKHKKKKSKKNKDKEKEKEKDDQK 1786
T+ + E K K KK + K KD +K+ +K D K
Sbjct: 443 STDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAK 478
Score = 70.1 bits (170), Expect = 2e-11
Identities = 114/539 (21%), Positives = 204/539 (37%), Gaps = 55/539 (10%)
Query: 1089 RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNK-PLDNKGEKR 1147
+KA K +K+ + P+K++ KK S E EEK K+ NE +K PL + E
Sbjct: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENE 170
Query: 1148 KRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAK 1207
+ K + + + ES + K ++ K K + +TE + + + P K
Sbjct: 171 QSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLH--------TKNNPKK 222
Query: 1208 KIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVD 1267
+K ++ + I SE S V + G+ + + + L +
Sbjct: 223 DLKRSKTSNDPI------------SEICSENSLNVDFLMLVGQSDDESINFD---AWLRN 267
Query: 1268 YTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAED---VIIMIQVPQSKWD-- 1322
Y+ +S S K DTK+ K+ + + D+ +D V ++ K D
Sbjct: 268 YSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK 327
Query: 1323 KDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH 1382
KD ++ E S K +K K + KYPE S + D
Sbjct: 328 KDTESTDAESGDSKDERKDTKKDKKKLKK-DDKKKDTKKYPESTDTESGDAKDARNDS-- 384
Query: 1383 EIIQHEVKSSKNSASSEKGK--TKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF 1440
++ K+SKN + K T D S E E+ E +K+ + +K+S D N
Sbjct: 385 ---RNLKKASKNDDKKKDAKKITFSTD-SESELESKESQKDEKKDKKDSKTDNKKSVKN- 439
Query: 1441 KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS 1500
+ S +A + K DS + ++ KK D K+ +KN + +S
Sbjct: 440 ---DEESTDADSEPKGDSKKGKKDEKKGKKDSKKDD--------KKKDAKKNAESTEMES 488
Query: 1501 PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1560
K K K ++D+ K D++ +++ K +T E +S
Sbjct: 489 DLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEES 548
Query: 1561 VDKNPCKDR--EKHVLEARNNKESSGNKLLYILNPPET---QVEKEQITGQIDKSTVKP 1614
+ K K + E A + E +K + ++ +T + ++ TG++ S KP
Sbjct: 549 LYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKP 607
Score = 65.1 bits (157), Expect = 6e-10
Identities = 90/459 (19%), Positives = 182/459 (39%), Gaps = 49/459 (10%)
Query: 908 HNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVE 967
H T K+ E + + + G KK K++ G + NPE S++ E
Sbjct: 102 HLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYAT---NPE----SKQIVEEKTKR 154
Query: 968 ENKTDSLFVLPSRDD--------ATPVRDEPMDAESITFKSVSEKDKRE----------- 1008
+N+ D + S ++ ++ E ++++++ K+ S+KDK++
Sbjct: 155 QNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVS-KNCSQKDKKDSKNSKKTNTEF 213
Query: 1009 ---RDKPKAKGDKTKRKNDGSAVSKKEN------IVKPAKGPQEKVDGE---RERSPRSE 1056
++ PK ++K ND + EN ++ + E ++ + R S +
Sbjct: 214 LHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNS 273
Query: 1057 PPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSK 1116
+ K D K++ S E K SK K K VK++ KKD K
Sbjct: 274 KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVK-----KNVKKDDKKKDVKK 328
Query: 1117 DVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIV 1176
D +S + + K ++ + K K + +K+ T++ D ES K ++ + +
Sbjct: 329 DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK 388
Query: 1177 KPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSE--- 1233
K S + D +K+ + + + S ++K + + K + +++ N +E ++
Sbjct: 389 KASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS 448
Query: 1234 KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS--TGGSPVRKSEEKTDTKRT 1291
+ + S K K+++ KGK K + + + T S + S+EK +K+
Sbjct: 449 EPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD 508
Query: 1292 VIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEE 1330
+ K + A ++ +K D ESEE
Sbjct: 509 IKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEE 547
Score = 54.7 bits (130), Expect = 8e-07
Identities = 69/280 (24%), Positives = 123/280 (43%), Gaps = 46/280 (16%)
Query: 1537 SRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPET 1596
+R++ P H T T E K KD + +++K+ G+ Y NP
Sbjct: 94 AREQTPFRHLYTSKTHLKKAEYKK-----SKDEKGGTPLKKDSKKKGGS---YATNPESK 145
Query: 1597 QV--EKEQITGQIDKSTVKP--KPQLSHSSRLSSDLTRETDEA------AFEPDYNESDS 1646
Q+ EK + + DK+ +K + + S S+ SS+ E+ + + D +S +
Sbjct: 146 QIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKN 205
Query: 1647 ESNVSVKEEESSGNISKDLK------DKIVEKAKE-SLDTAAVVQVGISRNQSHSSPSVS 1699
+ + + N KDLK D I E E SL+ ++ VG S ++S + +
Sbjct: 206 SKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWL 265
Query: 1700 PSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1759
R++S + S +++S + +D+KK KK + + K KK K +++K
Sbjct: 266 --RNYSQNNS--KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK------KVKK 315
Query: 1760 SQKHKHKKKKSKK-----------NKDKEKEKEKDDQKVK 1788
+ K KKK KK +KD+ K+ +KD +K+K
Sbjct: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLK 355
Score = 46.2 bits (108), Expect = 3e-04
Identities = 78/443 (17%), Positives = 173/443 (39%), Gaps = 24/443 (5%)
Query: 649 KEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSG 708
+ E+ KKSK TN ++ K ++ + S++ S + + +T + +
Sbjct: 168 ENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKN----SKKTNTEFLHTKNNPKKD 223
Query: 709 STRSRSYSRSFSRSHSRSYSRSPPYPRRGRG--KSRNYRSRSRSHGYHRSRSRSPPYRRY 766
RS++ + S S + G+ +S N+ + R++ + S++ S Y +Y
Sbjct: 224 LKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKY 283
Query: 767 HSRSRSPQAFRGQSPNKRNVPQGETEREYFNRY-----REVPPPYDMKAYYGRSVDFRDP 821
+ A + + + + + + ++ D ++ S D +D
Sbjct: 284 TKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE 343
Query: 822 FEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRRE 881
K+ ++ ++ ++ +K K Y ++ + R L +N + ++
Sbjct: 344 -RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK 402
Query: 882 DYVGGQSHRS-RNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRR 940
S + S EK +D + ++ES +A + KG+ K + +
Sbjct: 403 ITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEK 462
Query: 941 KGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKS 1000
KG++ + + ++K+ E T +E + S++ +D DA T
Sbjct: 463 KGKKDS--KKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDT--- 517
Query: 1001 VSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIK 1060
E E D+ G KT K GS +E++ KP G ++K+D S S+ ++
Sbjct: 518 --ESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKP--GAKKKIDESDGTSANSK--ME 571
Query: 1061 KAKEETPKTDNTKSSSSSQKDEK 1083
+ + ++K ++ ++K EK
Sbjct: 572 GLESKRGFRMSSKKTTFNEKGEK 594
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 97.1 bits (240), Expect = 1e-19
Identities = 203/994 (20%), Positives = 368/994 (37%), Gaps = 155/994 (15%)
Query: 844 GYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLS 903
G+++ S++ N S +R + NS + R++ G + +SR+ P+ +S
Sbjct: 130 GHSSQRTSAGSSSGTNSSGQRHDRESYNNSG-SSSRKKGQHGSEHSKSRSSSPGKPQAVS 188
Query: 904 ARDGHNQKDNTK---SKEKESENAPGDGKGNKHKKHRKR-RKGEESEGFLNPELLETSRK 959
+ + + + + SKE + +P D N R G+ S P L+ S
Sbjct: 189 SLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPPSLMSKSNS 248
Query: 960 S-REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDK 1018
++PT +V P D + + +E + S S + KP +K
Sbjct: 249 MLQKPTA---------YVRPM--DGQESMEPKLSSEH--YSSQSHGNSMTELKPSSKAHL 295
Query: 1019 TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTK---SS 1075
TK K + A G VD + S PP A KT+ +K +
Sbjct: 296 TKLKIPSQPLDAS------ASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPT 349
Query: 1076 SSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNE 1135
SQ+ TG ++ + ++K + ++ +K S+D E+ K P
Sbjct: 350 KESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGS 409
Query: 1136 KNKPLDNKGEKRKRKTEEK----------GVDKDFESSSMKISKLEVTEIVKPSPKRKME 1185
++P + E ++ G D + ESSS E ++ P P+
Sbjct: 410 NSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPE---P 466
Query: 1186 PDTEK--MDRTPEKDKISLSAPAKKIKLN-------RETGKKIGSTENISNTKEPSEKLE 1236
P T K +D K +PA + N ++ G++ G+ + ++T P E
Sbjct: 467 PPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSS 526
Query: 1237 ST------------------------SSKVKQEKVKGKVRRKVT----------GTEGSS 1262
+T S Q + GK + K G + S
Sbjct: 527 ATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIES 586
Query: 1263 STLVDYTST-------SSTGGS--PVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIM 1313
T VD S+ ++T GS P K E K+ + T K + + ++ + ++I
Sbjct: 587 ETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREII-- 644
Query: 1314 IQVPQSKWDKDDFES---EEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKE---- 1366
+ S D D+ ES + K + + KP+SV + S + E++
Sbjct: 645 -ETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLS 703
Query: 1367 --SEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQ 1424
SEP ++ K + + + K K + KG+ K+ V EK E +K ++
Sbjct: 704 PLSEPDDRYPLIVKIDLNLLTRIPGKPYKET-EPPKGEKKN----VPEKHTREAQKQAS- 757
Query: 1425 PEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDST-RASSNKDFT--------------- 1468
EK SN + + + + SK+ +T DK+ + + SSN++ +
Sbjct: 758 -EKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPA 816
Query: 1469 ---PNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKG 1525
P++D KT++ +R+ + S+ K+ K++ +K+S+S K K E K
Sbjct: 817 GPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEG----KTS 872
Query: 1526 TGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSG- 1584
+ + +PS T D+ +P TK V + + ++ EA+ K ++
Sbjct: 873 SSSKEVKEKAPSSSSNCPPSAPTLDSSKPRR-TKLVFDDRNYSADHYLQEAKKLKHNADA 931
Query: 1585 -----NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEP 1639
K +Y L+ + +E + + + P P S + L + + A P
Sbjct: 932 LSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIKYTMKLKNYLA--P 989
Query: 1640 DYNESDSESNVSVKEEES----------SGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1689
D +D V ES N K K + E K S + + G+
Sbjct: 990 DATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKT-LTEHLKNSYNNSQAPSPGLGS 1048
Query: 1690 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAES 1723
VSP S SG+ + SS+++S S
Sbjct: 1049 KAVGMPSPVSPKLSPGNSGNYSSGASSASASGSS 1082
Score = 74.7 bits (182), Expect = 7e-13
Identities = 184/954 (19%), Positives = 331/954 (34%), Gaps = 125/954 (13%)
Query: 594 PAGYSVPPPGFPPAPANLSTP-WVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKE-- 650
P ++P P PP+ S P + +H ++ T P S + + L+
Sbjct: 72 PKLVAIPKPTVPPSADEKSNPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSGLQSGH 131
Query: 651 -EEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGS 709
++ + TN Q+ R S++ S S S + +SKSRS S
Sbjct: 132 SSQRTSAGSSSGTNSSG---------QRHDRESYNNSGS--SSRKKGQHGSEHSKSRSSS 180
Query: 710 TRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKS-----RNYRSRSR---SHGYHRSRSRSP 761
S + SHSRS+ R KS N+ S SR S G H ++S P
Sbjct: 181 PGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPP 240
Query: 762 P-YRRYHSRSRSPQAF-RGQSPNKRNVPQGETE----REYFNRYREVPP----------- 804
+ +S + P A+ R + P+ +E + + N E+ P
Sbjct: 241 SLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKI 300
Query: 805 ---PYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENF- 860
P D A V D KE W + + P + + NF
Sbjct: 301 PSQPLDASA--SGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFG 358
Query: 861 --SPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKE 918
+R+ P N H+S+++ + + S+ D ++D K+
Sbjct: 359 TGEQKRYNPSKTSN---------------GHQSKSMLKDDLKLSSSEDSDGEQDCDKTMP 403
Query: 919 KESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLP 978
+ + + + + + H ++S E S E + + +
Sbjct: 404 RSTPGS--NSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSAS 461
Query: 979 SRDDATPVRDEPMD--AESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVK 1036
+ P +D + VS + + P ++G K + + G+ N
Sbjct: 462 PEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTG-----NSYT 516
Query: 1037 PAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITG--TPRKAHSK 1094
GP+E R ++ I+K E + + S S + G P+KA
Sbjct: 517 DTSGPKETSSATPGRDSKT---IQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKA 573
Query: 1095 SAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK 1154
+A+E + + E + D + + S + + ++KPN K + + R T EK
Sbjct: 574 AAEEPRGGLKI-ESETPVDLASSMPSSRHKAATKGSRKPNIK-----KESKSSPRPTAEK 627
Query: 1155 GVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRE 1214
K SS K ++ +E DT D + E + + S+ K +
Sbjct: 628 KKYKSTSKSSQKSREI-------------IETDTSSSD-SDESESLPPSSQTPKYPESNR 673
Query: 1215 TGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSST 1274
T K S E +E S + S ++++++ + +D +
Sbjct: 674 TPVKPSSVE-----EEDSFFRQRMFSPMEEKELLSPLSE--PDDRYPLIVKIDLNLLTRI 726
Query: 1275 GGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVK 1334
G P +++E K+ V E++ + A + + + K + D+ SE + K
Sbjct: 727 PGKPYKETEPPKGEKKNV---PEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPK 783
Query: 1335 STQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKN 1394
+ S+ KP+S N + + K EK+ PS +KD E S+
Sbjct: 784 TEDKNSAGHKPSS---NRESSKQSAAK--EKDLLPSPAGPVPSKDPKTE------HGSRK 832
Query: 1395 SASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSD 1454
S+ K S E K +ST +K++ +G S S+ KE S
Sbjct: 833 RTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKT-------EGKTSSSSKEVKEKAPSS 885
Query: 1455 KHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSA 1508
+ ++ D + R K +D R YS+ E +L D+ S + A
Sbjct: 886 SSNCPPSAPTLDSSKPRRTKLVFDDRNYSADHYLQEAKKLKHNADALSDRFEKA 939
Score = 67.4 bits (163), Expect = 1e-10
Identities = 153/803 (19%), Positives = 280/803 (34%), Gaps = 88/803 (10%)
Query: 1020 KRKNDGSAVSKKENIVKPA----------KGPQEKVDGERERSPRSEPPIKKAKEETPKT 1069
++++ GS S K V PA G Q +R + S + ++
Sbjct: 96 EQRHGGSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRES 155
Query: 1070 DNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEK 1129
N SSS +K G HSKS + KP + +S+ ++ + + ++
Sbjct: 156 YNNSGSSSRKK-----GQHGSEHSKS-RSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQR 209
Query: 1130 AKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTE 1189
+K P + + D+ R + + + F S M S + + KP+ + E
Sbjct: 210 SKSPRDPDANWDSPS--RVPFSSGQHSTQSFPPSLMSKSN---SMLQKPTAYVRPMDGQE 264
Query: 1190 KMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKG 1249
M+ K+S + + N T K S +++ K PS+ L++++S
Sbjct: 265 SME-----PKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASG--DVSCVD 317
Query: 1250 KVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAED 1309
++ +++T + T + + P E + T + YN T+
Sbjct: 318 EILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGT--GEQKRYNPSKTSNGHQ 375
Query: 1310 VIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEP 1369
M++ +D + E+ D T P S+ G +++PS+ SE
Sbjct: 376 SKSMLKDDLKLSSSEDSDGEQ-DCDKTMPRSTPGS--------NSEPSH------HNSEG 420
Query: 1370 SEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK-------NS 1422
++ + + S S S+SS+ + + E E P K N
Sbjct: 421 ADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNK 480
Query: 1423 TQPEKESNLDRLNEQGNFKSLSQSSKEAR---TSDKH-DSTRASSNKDFTPNRDKKTDYD 1478
P K S ++ N S KE R T + + D++ TP RD KT
Sbjct: 481 VNPHKVSPASSVDS--NIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQK 538
Query: 1479 TREYSSSKRRD--EKNELTRR----KDSPSRNKDSASGQKN---KPREERDLPKKGTGDS 1529
E +++ + + T+R K P + + +A+ + K E + + S
Sbjct: 539 GSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPS 598
Query: 1530 KKSNSSPSRDRKPHDHKATYDTKRPNEETK---SVDKNPCKDREKHVLEARNNKESSGNK 1586
+ ++ RKP+ K + + RP E K S K+ K RE + ++
Sbjct: 599 SRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESES 658
Query: 1587 LLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDS 1646
L PP +Q K + +++ VKP S + +E +E D
Sbjct: 659 L-----PPSSQTPKYP---ESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDD 710
Query: 1647 ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSP 1706
+ VK I +L +I K + + + + + + + S
Sbjct: 711 RYPLIVK-------IDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQA---SEKV 760
Query: 1707 SGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK 1766
S R H + + S+ K K + K HK + K+ A E +L S
Sbjct: 761 SNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVP 820
Query: 1767 KKKSKKNKDKEKEKEKDDQKVKS 1789
K K K +KS
Sbjct: 821 SKDPKTEHGSRKRTISQSSSLKS 843
Score = 64.7 bits (156), Expect = 8e-10
Identities = 144/742 (19%), Positives = 260/742 (35%), Gaps = 95/742 (12%)
Query: 1069 TDNTKSSSSSQKDEKITGTPRKAHSKS------AKEHQETKPVKEEKVKKDYSKDVKSEK 1122
++++KS SSS + + +HS+S +KEHQ +K ++ D V
Sbjct: 171 SEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSS 230
Query: 1123 ------------LTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKI--- 1167
++ +KP +P+D + + + E + +S ++
Sbjct: 231 GQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPS 290
Query: 1168 SKLEVTEIVKPSPK--RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENI 1225
SK +T++ PS D +D ++ S P I +T
Sbjct: 291 SKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKT---------- 340
Query: 1226 SNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEK 1285
+K P ES S + K K + S S L D SS+ S + +K
Sbjct: 341 EPSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDK 400
Query: 1286 TDTKRTVIKTME--EYNNDNTAPAEDVIIMIQVPQSKWDKD-DFESEEEDVKSTQPISSV 1342
T + T E +N++ + D +S D + ES D ++ +P S
Sbjct: 401 TMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSA 460
Query: 1343 GKPASVIKNVSTKPSNIVKYPEKESEPSEKIQ--KFTKDVSHEIIQHEVKSSKNSASSEK 1400
PE E P+ K Q + V+ + N SS+
Sbjct: 461 S-------------------PEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQG 501
Query: 1401 GKTKDRDY----SVLEKENPEKRKNSTQPEKESNLDRLNEQGNFK----SLSQSSKEART 1452
K + R+ S + P++ ++T + + +E G + + S S+ + RT
Sbjct: 502 YKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRT 561
Query: 1453 SDKHDSTRASSNKDFTPNRDKKTDYDTR-EYSSSKRRDEKNELTRRKDSPSRNKDSASGQ 1511
K +A P K + +T + +SS T+ P+ K+S S
Sbjct: 562 VGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSP 621
Query: 1512 KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKN--PCK-- 1567
+ P E+ K + S+KS D D + ++ K + N P K
Sbjct: 622 R--PTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPS 679
Query: 1568 --DREKHVLEARNNKESSGNKLLYILNPPE------TQVEKEQITGQIDKSTVKPKPQLS 1619
+ E R +LL L+ P+ +++ +T K + +P
Sbjct: 680 SVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKG 739
Query: 1620 HSSRLSSDLTRETDEAAFEP--------DYNESDSESNVSVK----EEESSGN---ISKD 1664
+ TRE + A E NE D+ ++ S K ++ S+G+ +++
Sbjct: 740 EKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRE 799
Query: 1665 LKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQ 1724
+ K K+ L + A H S + S+S S S + +S SS S
Sbjct: 800 SSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSS 859
Query: 1725 DSKKKKKKKEKKKHKKHKKHKK 1746
+ K+KK + K + +K
Sbjct: 860 STSKQKKTEGKTSSSSKEVKEK 881
Score = 35.0 bits (79), Expect = 0.66
Identities = 112/637 (17%), Positives = 216/637 (33%), Gaps = 59/637 (9%)
Query: 1176 VKPSPKRKMEPD--TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSE 1233
V PS K P+ ++ + + K + PA +++ + S + T S
Sbjct: 82 VPPSADEKSNPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSS 141
Query: 1234 KLESTSSKVKQEKV---KGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKR 1290
++S + + G RK G GS + S SS+ G P S + R
Sbjct: 142 SGTNSSGQRHDRESYNNSGSSSRK-KGQHGSEHS----KSRSSSPGKPQAVSSLNSSHSR 196
Query: 1291 TVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDD---FESEEEDVKSTQPISSVGKPAS 1347
+ + ND+ + + P + WD F S + +S P S + K S
Sbjct: 197 S-------HGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPP-SLMSKSNS 248
Query: 1348 VIKNVSTKPSNIVKYPEKESEPSEKIQ-KFTKDVSHEIIQHEVKSSKNS-------ASSE 1399
+++ KP+ V+ + + K+ + SH E+K S + S
Sbjct: 249 MLQ----KPTAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQP 304
Query: 1400 KGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDST 1459
+ D S +++ E + P + E F ++ S+++ +
Sbjct: 305 LDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTG-EQK 363
Query: 1460 RASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL--TRRKDSPSRNKDSASGQKNKPRE 1517
R + +K ++ K D + SSS+ D + + T + +P N + +
Sbjct: 364 RYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADN 423
Query: 1518 ERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEAR 1577
RD +G S S + D +A ++ + E + N + + + +
Sbjct: 424 SRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQ-LDNWLNKVN 482
Query: 1578 NNKESSGNKLLYILNPPETQVEK----EQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD 1633
+K S + + N P +Q K EQ TG T PK S + S ++
Sbjct: 483 PHKVSPASSV--DSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGS 540
Query: 1634 EAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSH 1693
E+ +S ++S+ + + K + E+ + L + V ++ +
Sbjct: 541 ESG--RGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPS 598
Query: 1694 SSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGT 1753
S + S P+ ++SK + +KK K K
Sbjct: 599 SRHKAATKGSRKPN--------------IKKESKSSPRPTAEKKKYKSTSKSSQKSREII 644
Query: 1754 EVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1790
E + S + + K E + K SV
Sbjct: 645 ETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSV 681
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 94.4 bits (233), Expect = 9e-19
Identities = 185/882 (20%), Positives = 341/882 (38%), Gaps = 149/882 (16%)
Query: 990 PMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKG----PQEKV 1045
P A+SI K ++ E+ +PKA+ T ++ + KK +K +K PQ+ V
Sbjct: 988 PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTE---TEKKPPPIKDSKSLTAEPQKAV 1044
Query: 1046 -DGERERSPRSEPPIKKAKEET------PKTDNTKSSSSSQ------------------- 1079
+ E+SP+ E K E P NT + +Q
Sbjct: 1045 LPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEW 1104
Query: 1080 ------KDEKITG-----------------TPRKAHSKSAKEHQETKPVKEEKVKKDYSK 1116
I+G +P ++S+ + P + K++
Sbjct: 1105 LCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV 1164
Query: 1117 DVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIV 1176
++EK+ ++ K EK P+ +K+ EE ++KD K +
Sbjct: 1165 KTEAEKVILEKVKETLSMEKIPPMVTTDQKQ----EESKLEKD---------KASALQEK 1211
Query: 1177 KPSPK-RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL 1235
KP P+ +K+ P+ EK+ +K + P + KK+ S +E L
Sbjct: 1212 KPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPE-------DKKLLPEAKTSAPEEQKHDL 1264
Query: 1236 ESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKT 1295
+ ++ +EK++G+V K T ++ G+P +E T +T+
Sbjct: 1265 LKSQVQIAEEKLEGRVAPKTVQEGKQPQTKME----GLPSGTPQSLPKEDDKTTKTI--- 1317
Query: 1296 MEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTK 1355
E+ TA + V + + + DK D S ++ KS Q +S G + I + +
Sbjct: 1318 KEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQP-KSPQGLSDTGYSSDGISSSLGE 1376
Query: 1356 PSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKEN 1415
+++ EK+ K F+++ S S+ S+ K + S+LE +
Sbjct: 1377 IPSLIPTDEKDILKGLKKDSFSQE------------SSPSSPSDLAKLESTVLSILEAQA 1424
Query: 1416 P----EKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNR 1471
EK + TQP + S ++ +Q +SLS++ E S++ KD T +
Sbjct: 1425 STLADEKSEKKTQPHEVSP-EQPKDQEKTQSLSETL-EITISEEEIKESQEERKD-TFKK 1481
Query: 1472 DKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKK 1531
D + D SSK EK+E D +R + S +++ E +P++ S
Sbjct: 1482 DSQQDIP-----SSKDHKEKSEFV--DDITTRREPYDSVEESSESENSPVPQRKRRTSVG 1534
Query: 1532 SNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYIL 1591
S+SS D D++ EE + K + + E N+L I
Sbjct: 1535 SSSS--------DEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEIS 1586
Query: 1592 NPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLT-------RETDEAAFEPD---- 1640
+ E+Q +KE+ G+ K T +L+ S S D + D+ AF+
Sbjct: 1587 SSTESQ-KKEETKGK-GKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELK 1644
Query: 1641 YNESDSESNVSVKEEESSG-------NISKDLKDKIVEKA---KESL---DTAAVVQVGI 1687
Y E+ S+ + + G ++ + DK ++ K SL + + +
Sbjct: 1645 YRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESL 1704
Query: 1688 SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKH 1747
+ + S S H+ S + S +S +S E DS KK E K+ +K +H
Sbjct: 1705 TDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRK----ARH 1760
Query: 1748 KKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKS 1789
+ H +E S + + +++ + K++EK++E + Q+ KS
Sbjct: 1761 RPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKS 1802
Score = 73.6 bits (179), Expect = 2e-12
Identities = 158/763 (20%), Positives = 291/763 (38%), Gaps = 100/763 (13%)
Query: 1036 KPAKGPQEKVDGERERSPRSEPP---IKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAH 1092
K A PQ K+ ++E+ ++E ++K KE ++ QK E+ K
Sbjct: 1147 KTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEE-----SKLE 1201
Query: 1093 SKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTE 1152
A QE KP+ EEK + EK+ ++E+K +K P D K + +
Sbjct: 1202 KDKASALQEKKPLPEEK-----KLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA 1256
Query: 1153 EKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL-SAPAKKIKL 1211
+ D S ++I++ ++ V P ++ + KM+ P SL K K
Sbjct: 1257 PEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT 1316
Query: 1212 NRETGKK--IGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTG--TEGSSSTLVD 1267
+E + + + KE +EK + S ++ K TG ++G SS+L +
Sbjct: 1317 IKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGE 1376
Query: 1268 YTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFE 1327
S T + K +K + + + + A E ++ I Q+ D
Sbjct: 1377 IPSLIPTDEKDILKGLKKD----SFSQESSPSSPSDLAKLESTVLSILEAQASTLAD--- 1429
Query: 1328 SEEEDVKSTQPIS-SVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ 1386
E+ K TQP S +P K S + + E+E + S Q+ KD + Q
Sbjct: 1430 --EKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKES---QEERKDTFKKDSQ 1484
Query: 1387 HEVKSSKN----SASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKS 1442
++ SSK+ S + T+ Y +E+ + + Q ++ +++ + +
Sbjct: 1485 QDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQE 1544
Query: 1443 LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS 1502
SQ S E + S+++D + + D + + + SS +K E T+ K +
Sbjct: 1545 DSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKIT 1604
Query: 1503 RNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVD 1562
K R L +K S + R HD E+ ++ D
Sbjct: 1605 AGK------------HRRLTRK---SSTSIDEDAGRRHSWHD-----------EDDEAFD 1638
Query: 1563 KNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSS 1622
++P L+ R K +L+ + + ++ ST+ K S
Sbjct: 1639 ESP-------ELKYRETKSQESEELVVTGGGGLRRFKTIEL-----NSTIADKYSAESSQ 1686
Query: 1623 RLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAV 1682
+ +S E EP E + ES E+ S G S L A +
Sbjct: 1687 KKTSLYFDE------EP---ELEMESLTDSPEDRSRGEGSSSL------HASSFTPGTSP 1731
Query: 1683 VQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHK 1742
V S SSPS S ++ R H + E DS ++++ +E+++ K +
Sbjct: 1732 TSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIE--DSSEEEELREEEELLKEQ 1789
Query: 1743 KHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQ 1785
+ ++ E+E+ Q+ K KKSKK+KD+ + + + ++
Sbjct: 1790 EKQR---------EIEQQQR-KSSSKKSKKDKDELRAQRRRER 1822
Score = 64.3 bits (155), Expect = 1e-09
Identities = 165/820 (20%), Positives = 294/820 (35%), Gaps = 127/820 (15%)
Query: 1032 ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKA 1091
+++ KPA + V E++++P ++ K+ K P TD SSS++ K + +
Sbjct: 727 DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPD-----IPSS 781
Query: 1092 HSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKA-KKPNEKNKPLDNKGEKRKRK 1150
+S E + T P+K + K S EK++ + KA +P +K + + G + K
Sbjct: 782 KVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESK 841
Query: 1151 TEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIK 1210
+K VD + K E E K K +PD + M + + +
Sbjct: 842 -GQKQVD--------PVQKKE--EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVP 890
Query: 1211 LNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTS 1270
+++ K + S + QE V GK+ +S L+
Sbjct: 891 TPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI---- 946
Query: 1271 TSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKW-DKDDFESE 1329
ST G P S+ + AP + Q P S+ K ++
Sbjct: 947 --STAGQPGPHSQ-----------------SGPGAPMKQAPAPSQPPTSQGPPKSTGQAP 987
Query: 1330 EEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPS--EKIQKFTKDVSHEIIQH 1387
KS PA+ + + VK E E +P + + T + ++
Sbjct: 988 PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047
Query: 1388 EV-KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLN----------- 1435
++ KS K ++ KT + ++ K+ P + + NL N
Sbjct: 1048 KLEKSPKPESTCPLCKT---ELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEW 1104
Query: 1436 -------------EQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREY 1482
+ G+ + + + + S T +SS K P + K +E
Sbjct: 1105 LCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV 1164
Query: 1483 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPK-KGTGDSKKSNSSPSRDRK 1541
K EK L + K++ S K ++ +EE L K K + +K +
Sbjct: 1165 ---KTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLI 1221
Query: 1542 PHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKE 1601
P + K + K+P E +K P + +K + EA K S+ + + L + Q+ +E
Sbjct: 1222 PEEEKIRSEEKKPLLE----EKKPTPEDKKLLPEA---KTSAPEEQKHDLLKSQVQIAEE 1274
Query: 1602 QITGQIDKSTVK--PKPQLSHS---SRLSSDLTRETDE------------AAFEPDYNES 1644
++ G++ TV+ +PQ S L +E D+ +PD E
Sbjct: 1275 KLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEP 1334
Query: 1645 DSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSP---- 1700
E + KE++ S D K+ + L GIS + PS+ P
Sbjct: 1335 GKEK--TEKEDDKS-----DTSSSQQPKSPQGLSDTGYSSDGISSSLG-EIPSLIPTDEK 1386
Query: 1701 -----------SRSHSPSGSQ--TRSHSSSASSAESQDSKKKKKKKEKKKHKKH---KKH 1744
S+ SPS + S+ S E+Q S +K EKK ++
Sbjct: 1387 DILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQP 1446
Query: 1745 KKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDD 1784
K +K LE + + K+ ++ KD K+ + D
Sbjct: 1447 KDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQD 1486
Score = 61.2 bits (147), Expect = 9e-09
Identities = 116/574 (20%), Positives = 223/574 (38%), Gaps = 62/574 (10%)
Query: 1011 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTD 1070
K K KT ++ + K + V+P K EK D + + S +P + +T +
Sbjct: 1308 KEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSS 1367
Query: 1071 NTKSSSSSQ------KDEK--ITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEK 1122
+ SSS + DEK + G + + S +E + P K++ ++++
Sbjct: 1368 DGISSSLGEIPSLIPTDEKDILKGLKKDSFS---QESSPSSPSDLAKLESTVLSILEAQA 1424
Query: 1123 LTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKR 1182
T +EK++K K +P + E+ K + + + + + E + IS+ E+ E +
Sbjct: 1425 STLADEKSEK---KTQPHEVSPEQPKDQEKTQSLSETLE---ITISEEEIKE------SQ 1472
Query: 1183 KMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKV 1242
+ DT K D + I +++ +K ++I+ +EP + +E SS+
Sbjct: 1473 EERKDTFKKDSQQD------------IPSSKDHKEKSEFVDDITTRREPYDSVEE-SSES 1519
Query: 1243 KQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND 1302
+ V + RR G+ S +Y S G EE+ ++ +I+ + D
Sbjct: 1520 ENSPVPQRKRRTSVGSSSSD----EYKQEDSQG-----SGEEEDFIRKQIIEMSAD--ED 1568
Query: 1303 NTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1362
+ +D I Q+ + + + EE K + GK + + ST
Sbjct: 1569 ASGSEDDEFIRNQLKEISSSTESQKKEETKGKGK---ITAGKHRRLTRKSSTSIDE--DA 1623
Query: 1363 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1422
+ S E + F D S E+ E KS ++ G R + +E + K S
Sbjct: 1624 GRRHSWHDEDDEAF--DESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYS 1681
Query: 1423 TQPEKESNLDRLNEQG--NFKSLSQSSKEARTSDKHDSTRASS-NKDFTPNRDKKTDYDT 1479
+ ++ +E+ +SL+ S ++ + S ASS +P D D+
Sbjct: 1682 AESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDS 1741
Query: 1480 REYSSSKRRDEKNE--LTRRKDSPSRNKDSASGQKNKPREERDLPK---KGTGDSKKSNS 1534
S K+ + K + R P S ++ + REE +L K K ++
Sbjct: 1742 DSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRK 1801
Query: 1535 SPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKD 1568
S S+ K + +R +T + +P +D
Sbjct: 1802 SSSKKSKKDKDELRAQRRRERPKTPPSNLSPIED 1835
Score = 43.5 bits (101), Expect = 0.002
Identities = 71/305 (23%), Positives = 101/305 (33%), Gaps = 42/305 (13%)
Query: 332 LRKQLPPPP-PPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSN 390
++ LP P PPI P P +P + P + P P+ L
Sbjct: 294 VKPSLPSPSKPPIQQPTPG-----KPPAQQPGHEKSQP---GPAKPPAQPSGLTKPLAQQ 345
Query: 391 QSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGT 450
++ PPV ++ P P + + + G + S + P A LA G
Sbjct: 346 PGTVKPPVQPPGTTKPPAQP-----LGPAKPPAQQTGSEKPSSEQPGPKA-LAQPPGVGK 399
Query: 451 SSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNK 510
+ + QV GTP L Q GP + +PG G+
Sbjct: 400 TPAQQPGPAKPPTQQV---GTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGK-------- 448
Query: 511 LGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYP---P 567
P QQ G+ S ++ ++ + GP+ P P PPP P
Sbjct: 449 -----IPAQQAGPGKTSAQQT-----GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAK 498
Query: 568 PPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNT 627
PP P PP Q P P Q P S PP P A S S +A +T
Sbjct: 499 PPSQQPGSTKPPPQQPGPAKPSPQQPG---STKPPSQQPGSAKPSAQQPSPAKPSAQQST 555
Query: 628 IPTTQ 632
P +Q
Sbjct: 556 KPVSQ 560
Score = 43.5 bits (101), Expect = 0.002
Identities = 98/426 (23%), Positives = 140/426 (32%), Gaps = 92/426 (21%)
Query: 231 GKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTA--- 287
GK +PP + PS+ +P + +C +C V + C EC T
Sbjct: 564 GKPLQPPTV--SPSAKQPPSQGLP-KTICPLCNTTELLLHVPEKANFNTCTECQTTVCSL 620
Query: 288 --------LLESDEHTCPTCHQN-----DVSPDALIANKFLRQAVNNFKNETGYTKRLRK 334
L E E C C D++P L+ A T + K
Sbjct: 621 CGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTA------PVTTTSAVSK 674
Query: 335 QLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSL 394
P P P + Q L ++P ++ PL V + H +PS +
Sbjct: 675 SSPQPQQTSPKKDAAPK---QDLSKAPEPKKPPPL---VKQPTLHGSPSAKA-------- 720
Query: 395 APPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNK----ILPAAALASEHSKGT 450
P + S PAP + SV SE+ P D K + P L S S T
Sbjct: 721 KQPPEADSLSKPAPPKEP------SVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774
Query: 451 S----SIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWE 506
S + + EEK TP L S Q P TG RP +
Sbjct: 775 KPDIPSSKVQSQAEEKT-------TPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASD 827
Query: 507 HSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYP 566
++S P S ++G+ + Q+ + P T +
Sbjct: 828 SK-----IISHPGP---------SSESKGQKQVDPVQKKEEPKKAQTKM----------S 863
Query: 567 PPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPW-VSSGVQTAHS 625
P P P+P G P P PG P AG +VP P P P S + ++ G T
Sbjct: 864 PKPDAKPMPKGSPTP-------PGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAP 916
Query: 626 NTIPTT 631
+ PTT
Sbjct: 917 KSQPTT 922
Score = 41.6 bits (96), Expect = 0.007
Identities = 82/352 (23%), Positives = 113/352 (32%), Gaps = 74/352 (21%)
Query: 302 NDVSPDALIANKF-----LRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQP 356
N +S + + NKF + + + + T K ++K+ P I PP LQ
Sbjct: 161 NALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPP-------LQQ 213
Query: 357 LMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATV 416
PI +QQ P P+ T SISS + PP +G P P P
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGT--PKSISSQQPEKIKSQPPGTGKPIQGPTQTP------ 265
Query: 417 SISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLG 476
+D+ LP AS + I + G
Sbjct: 266 --------------QTDHAKLPLQRDASRPQTKQADI--------------------VRG 291
Query: 477 QSLLHGQLIPTTGPVRINT-ARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRG 535
+S+ P+ P++ T +P +PG E S PP Q + +
Sbjct: 292 ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP--GPAKPPAQPSGLTKPLAQQPGTV 349
Query: 536 RHHSERSQRTQGPSLPATPVFVPV-----PPPPLYPPPPHTLPLPPGV---PPPQFSPQF 587
+ + T+ P+ P P P P P P L PPGV P Q P
Sbjct: 350 KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAK 409
Query: 588 PP----GQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPP 635
PP G P P AP TP VQ IP QA P
Sbjct: 410 PPTQQVGTPKPLAQQPGLQSPAKAPGPTKTP-----VQQPGPGKIPAQQAGP 456
Score = 40.0 bits (92), Expect = 0.020
Identities = 33/105 (31%), Positives = 43/105 (40%), Gaps = 27/105 (25%)
Query: 549 SLPATP--------VFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP 600
SLPA P + + PPP PPPP P PP PPP PP PPP P
Sbjct: 2385 SLPAKPRPFFRSSSLDISAQPPPPPPPPP---PPPPPPPPPP-----PPPLPPPTS---P 2433
Query: 601 PPGFPP-------APANLSTPWVSSGVQTAHSNTIPTTQAPPLSR 638
P P +P +TP + V T + + + P++R
Sbjct: 2434 KPTILPKKKLTVASPVTTATP-LFDAVTTLETTAVLRSNGLPVTR 2477
Score = 38.9 bits (89), Expect = 0.045
Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 12/86 (13%)
Query: 335 QLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIP-----VTSSSTHPAPSISSLTS 389
Q PPPPPP PPP P P + P S + P ++P V S T P ++T+
Sbjct: 2404 QPPPPPPPPPPPPPPPPPPPPPPLPPPTSPK--PTILPKKKLTVASPVTTATPLFDAVTT 2461
Query: 390 NQSSLAPPVSGNP-----SSAPAPVP 410
+++ +G P ++AP PVP
Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPPVP 2487
Score = 38.5 bits (88), Expect = 0.059
Identities = 29/82 (35%), Positives = 37/82 (45%), Gaps = 8/82 (9%)
Query: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVS 617
P PPPP PPPP P PP +PPP SP+ P P +V P P + +
Sbjct: 2407 PPPPPPPPPPPPPPPPPPPPLPPPT-SPK--PTILPKKKLTVASPVTTATPLFDAVTTLE 2463
Query: 618 SGVQTAHSNTIPTTQ----APP 635
+ SN +P T+ APP
Sbjct: 2464 T-TAVLRSNGLPVTRICTTAPP 2484
Score = 35.8 bits (81), Expect = 0.38
Identities = 28/102 (27%), Positives = 36/102 (35%), Gaps = 10/102 (9%)
Query: 535 GRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPP 594
G + +Q PS + +P P P + + P PPP P PP PP
Sbjct: 2364 GETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPP- 2422
Query: 595 AGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPL 636
PPP PP + T + A P T A PL
Sbjct: 2423 -----PPPPLPPPTSPKPTILPKKKLTVAS----PVTTATPL 2455
Score = 35.4 bits (80), Expect = 0.50
Identities = 63/283 (22%), Positives = 103/283 (36%), Gaps = 70/283 (24%)
Query: 889 HRSRNIGSNYPEKLSARDGHN--------QKDNTKSKEKESENAPGDGKGNKHKKHRKRR 940
HR + + S++P K S R K T + + PG K K R
Sbjct: 82 HRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSR 141
Query: 941 KGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKS 1000
+L E + S P + E ++L + S + + P D S + S
Sbjct: 142 T----------DLKEEHKSSMMPGFLSE--VNALSAVSSVVN----KFNPFDLISDSEAS 185
Query: 1001 VSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIK 1060
E K+++ K +G K E I+KP Q +++ P +P
Sbjct: 186 QEETTKKQKVVQKEQG-------------KPEGIIKPPLQQQPPKPIPKQQGPGRDPL-- 230
Query: 1061 KAKEETPKTDNTKSSSSSQKDEKI--------------TGTPRKAHSKSAKEHQETKP-- 1104
+ D T S SSQ+ EKI T TP+ H+K + ++P
Sbjct: 231 -------QQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQT 283
Query: 1105 -----VKEEKVKKDYSKDVKS--EKLTTKEEKAKKP-NEKNKP 1139
V+ E VK K ++ T + A++P +EK++P
Sbjct: 284 KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP 326
Score = 35.0 bits (79), Expect = 0.66
Identities = 51/222 (22%), Positives = 86/222 (38%), Gaps = 22/222 (9%)
Query: 1075 SSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPN 1134
SS K + T A SKS+ + Q+T P K+ K+D SK + +K K+P
Sbjct: 655 SSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKK---PPPLVKQPT 711
Query: 1135 EKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRT 1194
P + + + K S + K V + KP + ++P T+ + +
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVAD-DKPKQPKMVKPTTDLVSSS 770
Query: 1195 PEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRK 1254
K + P+ K++ E + + +++ +PS+ T KV K R
Sbjct: 771 SATTKPDI--PSSKVQSQAE---EKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR-- 823
Query: 1255 VTGTEGSSSTLVDYTSTSSTGG-----SPVRKSEE--KTDTK 1289
S S ++ + SS PV+K EE K TK
Sbjct: 824 ----PASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTK 861
Score = 32.7 bits (73), Expect = 3.3
Identities = 79/334 (23%), Positives = 110/334 (32%), Gaps = 77/334 (23%)
Query: 333 RKQLPPPPPPIPPPRPLIQRNLQPLMR-SPISRQQDPLMIPVTSSSTHPAPSISSLTSNQ 391
++ L P P PP PL++ QP + SP ++ + P P S + PAP ++
Sbjct: 691 KQDLSKAPEPKKPP-PLVK---QPTLHGSPSAKAKQP---PEADSLSKPAPPKEPSVPSE 743
Query: 392 SSLAPPVSGNP--------------SSAPAPVPDITATVSISVHSEKSDGPFRDS----- 432
AP P SS+ PDI ++ S EK+ P +
Sbjct: 744 QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPS 803
Query: 433 -------------DNKILPAAALASE--HSKGTSSIAITALMEEKGY-QVPVLGTPSLLG 476
D+K +P A S+ G SS E KG QV +
Sbjct: 804 QSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSS-------ESKGQKQVDPVQKKEEPK 856
Query: 477 QSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYR-SINRG 535
++ P P+ + P G RP G V PQQ + + R S+N G
Sbjct: 857 KAQTKMSPKPDAKPMPKGSPTPPGPRP------TAGQTVPTPQQSPKPQEQSRRFSLNLG 910
Query: 536 R-HHSERSQRTQGPSLPATPVF------------------VPVPPPPLYPPPPHTLPLPP 576
+ +SQ T +F P P P P P
Sbjct: 911 SITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAP 970
Query: 577 GVPPPQFSPQFPPGQPPPA-GYSVPPPGFPPAPA 609
PP P GQ PPA S+P APA
Sbjct: 971 SQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPA 1004
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 94.4 bits (233), Expect = 9e-19
Identities = 185/882 (20%), Positives = 341/882 (38%), Gaps = 149/882 (16%)
Query: 990 PMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKG----PQEKV 1045
P A+SI K ++ E+ +PKA+ T ++ + KK +K +K PQ+ V
Sbjct: 988 PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTE---TEKKPPPIKDSKSLTAEPQKAV 1044
Query: 1046 -DGERERSPRSEPPIKKAKEET------PKTDNTKSSSSSQ------------------- 1079
+ E+SP+ E K E P NT + +Q
Sbjct: 1045 LPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEW 1104
Query: 1080 ------KDEKITG-----------------TPRKAHSKSAKEHQETKPVKEEKVKKDYSK 1116
I+G +P ++S+ + P + K++
Sbjct: 1105 LCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV 1164
Query: 1117 DVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIV 1176
++EK+ ++ K EK P+ +K+ EE ++KD K +
Sbjct: 1165 KTEAEKVILEKVKETLSMEKIPPMVTTDQKQ----EESKLEKD---------KASALQEK 1211
Query: 1177 KPSPK-RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL 1235
KP P+ +K+ P+ EK+ +K + P + KK+ S +E L
Sbjct: 1212 KPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPE-------DKKLLPEAKTSAPEEQKHDL 1264
Query: 1236 ESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKT 1295
+ ++ +EK++G+V K T ++ G+P +E T +T+
Sbjct: 1265 LKSQVQIAEEKLEGRVAPKTVQEGKQPQTKME----GLPSGTPQSLPKEDDKTTKTI--- 1317
Query: 1296 MEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTK 1355
E+ TA + V + + + DK D S ++ KS Q +S G + I + +
Sbjct: 1318 KEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQP-KSPQGLSDTGYSSDGISSSLGE 1376
Query: 1356 PSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKEN 1415
+++ EK+ K F+++ S S+ S+ K + S+LE +
Sbjct: 1377 IPSLIPTDEKDILKGLKKDSFSQE------------SSPSSPSDLAKLESTVLSILEAQA 1424
Query: 1416 P----EKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNR 1471
EK + TQP + S ++ +Q +SLS++ E S++ KD T +
Sbjct: 1425 STLADEKSEKKTQPHEVSP-EQPKDQEKTQSLSETL-EITISEEEIKESQEERKD-TFKK 1481
Query: 1472 DKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKK 1531
D + D SSK EK+E D +R + S +++ E +P++ S
Sbjct: 1482 DSQQDIP-----SSKDHKEKSEFV--DDITTRREPYDSVEESSESENSPVPQRKRRTSVG 1534
Query: 1532 SNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYIL 1591
S+SS D D++ EE + K + + E N+L I
Sbjct: 1535 SSSS--------DEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEIS 1586
Query: 1592 NPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLT-------RETDEAAFEPD---- 1640
+ E+Q +KE+ G+ K T +L+ S S D + D+ AF+
Sbjct: 1587 SSTESQ-KKEETKGK-GKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELK 1644
Query: 1641 YNESDSESNVSVKEEESSG-------NISKDLKDKIVEKA---KESL---DTAAVVQVGI 1687
Y E+ S+ + + G ++ + DK ++ K SL + + +
Sbjct: 1645 YRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESL 1704
Query: 1688 SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKH 1747
+ + S S H+ S + S +S +S E DS KK E K+ +K +H
Sbjct: 1705 TDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRK----ARH 1760
Query: 1748 KKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKS 1789
+ H +E S + + +++ + K++EK++E + Q+ KS
Sbjct: 1761 RPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKS 1802
Score = 73.6 bits (179), Expect = 2e-12
Identities = 158/763 (20%), Positives = 291/763 (38%), Gaps = 100/763 (13%)
Query: 1036 KPAKGPQEKVDGERERSPRSEPP---IKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAH 1092
K A PQ K+ ++E+ ++E ++K KE ++ QK E+ K
Sbjct: 1147 KTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEE-----SKLE 1201
Query: 1093 SKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTE 1152
A QE KP+ EEK + EK+ ++E+K +K P D K + +
Sbjct: 1202 KDKASALQEKKPLPEEK-----KLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA 1256
Query: 1153 EKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL-SAPAKKIKL 1211
+ D S ++I++ ++ V P ++ + KM+ P SL K K
Sbjct: 1257 PEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT 1316
Query: 1212 NRETGKK--IGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTG--TEGSSSTLVD 1267
+E + + + KE +EK + S ++ K TG ++G SS+L +
Sbjct: 1317 IKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGE 1376
Query: 1268 YTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFE 1327
S T + K +K + + + + A E ++ I Q+ D
Sbjct: 1377 IPSLIPTDEKDILKGLKKD----SFSQESSPSSPSDLAKLESTVLSILEAQASTLAD--- 1429
Query: 1328 SEEEDVKSTQPIS-SVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ 1386
E+ K TQP S +P K S + + E+E + S Q+ KD + Q
Sbjct: 1430 --EKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKES---QEERKDTFKKDSQ 1484
Query: 1387 HEVKSSKN----SASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKS 1442
++ SSK+ S + T+ Y +E+ + + Q ++ +++ + +
Sbjct: 1485 QDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQE 1544
Query: 1443 LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS 1502
SQ S E + S+++D + + D + + + SS +K E T+ K +
Sbjct: 1545 DSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKIT 1604
Query: 1503 RNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVD 1562
K R L +K S + R HD E+ ++ D
Sbjct: 1605 AGK------------HRRLTRK---SSTSIDEDAGRRHSWHD-----------EDDEAFD 1638
Query: 1563 KNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSS 1622
++P L+ R K +L+ + + ++ ST+ K S
Sbjct: 1639 ESP-------ELKYRETKSQESEELVVTGGGGLRRFKTIEL-----NSTIADKYSAESSQ 1686
Query: 1623 RLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAV 1682
+ +S E EP E + ES E+ S G S L A +
Sbjct: 1687 KKTSLYFDE------EP---ELEMESLTDSPEDRSRGEGSSSL------HASSFTPGTSP 1731
Query: 1683 VQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHK 1742
V S SSPS S ++ R H + E DS ++++ +E+++ K +
Sbjct: 1732 TSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIE--DSSEEEELREEEELLKEQ 1789
Query: 1743 KHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQ 1785
+ ++ E+E+ Q+ K KKSKK+KD+ + + + ++
Sbjct: 1790 EKQR---------EIEQQQR-KSSSKKSKKDKDELRAQRRRER 1822
Score = 64.3 bits (155), Expect = 1e-09
Identities = 165/820 (20%), Positives = 294/820 (35%), Gaps = 127/820 (15%)
Query: 1032 ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKA 1091
+++ KPA + V E++++P ++ K+ K P TD SSS++ K + +
Sbjct: 727 DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPD-----IPSS 781
Query: 1092 HSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKA-KKPNEKNKPLDNKGEKRKRK 1150
+S E + T P+K + K S EK++ + KA +P +K + + G + K
Sbjct: 782 KVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESK 841
Query: 1151 TEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIK 1210
+K VD + K E E K K +PD + M + + +
Sbjct: 842 -GQKQVD--------PVQKKE--EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVP 890
Query: 1211 LNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTS 1270
+++ K + S + QE V GK+ +S L+
Sbjct: 891 TPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI---- 946
Query: 1271 TSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKW-DKDDFESE 1329
ST G P S+ + AP + Q P S+ K ++
Sbjct: 947 --STAGQPGPHSQ-----------------SGPGAPMKQAPAPSQPPTSQGPPKSTGQAP 987
Query: 1330 EEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPS--EKIQKFTKDVSHEIIQH 1387
KS PA+ + + VK E E +P + + T + ++
Sbjct: 988 PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047
Query: 1388 EV-KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLN----------- 1435
++ KS K ++ KT + ++ K+ P + + NL N
Sbjct: 1048 KLEKSPKPESTCPLCKT---ELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEW 1104
Query: 1436 -------------EQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREY 1482
+ G+ + + + + S T +SS K P + K +E
Sbjct: 1105 LCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV 1164
Query: 1483 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPK-KGTGDSKKSNSSPSRDRK 1541
K EK L + K++ S K ++ +EE L K K + +K +
Sbjct: 1165 ---KTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLI 1221
Query: 1542 PHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKE 1601
P + K + K+P E +K P + +K + EA K S+ + + L + Q+ +E
Sbjct: 1222 PEEEKIRSEEKKPLLE----EKKPTPEDKKLLPEA---KTSAPEEQKHDLLKSQVQIAEE 1274
Query: 1602 QITGQIDKSTVK--PKPQLSHS---SRLSSDLTRETDE------------AAFEPDYNES 1644
++ G++ TV+ +PQ S L +E D+ +PD E
Sbjct: 1275 KLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEP 1334
Query: 1645 DSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSP---- 1700
E + KE++ S D K+ + L GIS + PS+ P
Sbjct: 1335 GKEK--TEKEDDKS-----DTSSSQQPKSPQGLSDTGYSSDGISSSLG-EIPSLIPTDEK 1386
Query: 1701 -----------SRSHSPSGSQ--TRSHSSSASSAESQDSKKKKKKKEKKKHKKH---KKH 1744
S+ SPS + S+ S E+Q S +K EKK ++
Sbjct: 1387 DILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQP 1446
Query: 1745 KKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDD 1784
K +K LE + + K+ ++ KD K+ + D
Sbjct: 1447 KDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQD 1486
Score = 61.2 bits (147), Expect = 9e-09
Identities = 116/574 (20%), Positives = 223/574 (38%), Gaps = 62/574 (10%)
Query: 1011 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTD 1070
K K KT ++ + K + V+P K EK D + + S +P + +T +
Sbjct: 1308 KEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSS 1367
Query: 1071 NTKSSSSSQ------KDEK--ITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEK 1122
+ SSS + DEK + G + + S +E + P K++ ++++
Sbjct: 1368 DGISSSLGEIPSLIPTDEKDILKGLKKDSFS---QESSPSSPSDLAKLESTVLSILEAQA 1424
Query: 1123 LTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKR 1182
T +EK++K K +P + E+ K + + + + + E + IS+ E+ E +
Sbjct: 1425 STLADEKSEK---KTQPHEVSPEQPKDQEKTQSLSETLE---ITISEEEIKE------SQ 1472
Query: 1183 KMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKV 1242
+ DT K D + I +++ +K ++I+ +EP + +E SS+
Sbjct: 1473 EERKDTFKKDSQQD------------IPSSKDHKEKSEFVDDITTRREPYDSVEE-SSES 1519
Query: 1243 KQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND 1302
+ V + RR G+ S +Y S G EE+ ++ +I+ + D
Sbjct: 1520 ENSPVPQRKRRTSVGSSSSD----EYKQEDSQG-----SGEEEDFIRKQIIEMSAD--ED 1568
Query: 1303 NTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1362
+ +D I Q+ + + + EE K + GK + + ST
Sbjct: 1569 ASGSEDDEFIRNQLKEISSSTESQKKEETKGKGK---ITAGKHRRLTRKSSTSIDE--DA 1623
Query: 1363 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1422
+ S E + F D S E+ E KS ++ G R + +E + K S
Sbjct: 1624 GRRHSWHDEDDEAF--DESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYS 1681
Query: 1423 TQPEKESNLDRLNEQG--NFKSLSQSSKEARTSDKHDSTRASS-NKDFTPNRDKKTDYDT 1479
+ ++ +E+ +SL+ S ++ + S ASS +P D D+
Sbjct: 1682 AESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDS 1741
Query: 1480 REYSSSKRRDEKNE--LTRRKDSPSRNKDSASGQKNKPREERDLPK---KGTGDSKKSNS 1534
S K+ + K + R P S ++ + REE +L K K ++
Sbjct: 1742 DSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRK 1801
Query: 1535 SPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKD 1568
S S+ K + +R +T + +P +D
Sbjct: 1802 SSSKKSKKDKDELRAQRRRERPKTPPSNLSPIED 1835
Score = 43.5 bits (101), Expect = 0.002
Identities = 71/305 (23%), Positives = 101/305 (33%), Gaps = 42/305 (13%)
Query: 332 LRKQLPPPP-PPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSN 390
++ LP P PPI P P +P + P + P P+ L
Sbjct: 294 VKPSLPSPSKPPIQQPTPG-----KPPAQQPGHEKSQP---GPAKPPAQPSGLTKPLAQQ 345
Query: 391 QSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGT 450
++ PPV ++ P P + + + G + S + P A LA G
Sbjct: 346 PGTVKPPVQPPGTTKPPAQP-----LGPAKPPAQQTGSEKPSSEQPGPKA-LAQPPGVGK 399
Query: 451 SSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNK 510
+ + QV GTP L Q GP + +PG G+
Sbjct: 400 TPAQQPGPAKPPTQQV---GTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGK-------- 448
Query: 511 LGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYP---P 567
P QQ G+ S ++ ++ + GP+ P P PPP P
Sbjct: 449 -----IPAQQAGPGKTSAQQT-----GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAK 498
Query: 568 PPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNT 627
PP P PP Q P P Q P S PP P A S S +A +T
Sbjct: 499 PPSQQPGSTKPPPQQPGPAKPSPQQPG---STKPPSQQPGSAKPSAQQPSPAKPSAQQST 555
Query: 628 IPTTQ 632
P +Q
Sbjct: 556 KPVSQ 560
Score = 43.5 bits (101), Expect = 0.002
Identities = 98/426 (23%), Positives = 140/426 (32%), Gaps = 92/426 (21%)
Query: 231 GKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTA--- 287
GK +PP + PS+ +P + +C +C V + C EC T
Sbjct: 564 GKPLQPPTV--SPSAKQPPSQGLP-KTICPLCNTTELLLHVPEKANFNTCTECQTTVCSL 620
Query: 288 --------LLESDEHTCPTCHQN-----DVSPDALIANKFLRQAVNNFKNETGYTKRLRK 334
L E E C C D++P L+ A T + K
Sbjct: 621 CGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTA------PVTTTSAVSK 674
Query: 335 QLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSL 394
P P P + Q L ++P ++ PL V + H +PS +
Sbjct: 675 SSPQPQQTSPKKDAAPK---QDLSKAPEPKKPPPL---VKQPTLHGSPSAKA-------- 720
Query: 395 APPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNK----ILPAAALASEHSKGT 450
P + S PAP + SV SE+ P D K + P L S S T
Sbjct: 721 KQPPEADSLSKPAPPKEP------SVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774
Query: 451 S----SIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWE 506
S + + EEK TP L S Q P TG RP +
Sbjct: 775 KPDIPSSKVQSQAEEKT-------TPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASD 827
Query: 507 HSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYP 566
++S P S ++G+ + Q+ + P T +
Sbjct: 828 SK-----IISHPGP---------SSESKGQKQVDPVQKKEEPKKAQTKM----------S 863
Query: 567 PPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPW-VSSGVQTAHS 625
P P P+P G P P PG P AG +VP P P P S + ++ G T
Sbjct: 864 PKPDAKPMPKGSPTP-------PGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAP 916
Query: 626 NTIPTT 631
+ PTT
Sbjct: 917 KSQPTT 922
Score = 41.6 bits (96), Expect = 0.007
Identities = 82/352 (23%), Positives = 113/352 (32%), Gaps = 74/352 (21%)
Query: 302 NDVSPDALIANKF-----LRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQP 356
N +S + + NKF + + + + T K ++K+ P I PP LQ
Sbjct: 161 NALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPP-------LQQ 213
Query: 357 LMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATV 416
PI +QQ P P+ T SISS + PP +G P P P
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGT--PKSISSQQPEKIKSQPPGTGKPIQGPTQTP------ 265
Query: 417 SISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLG 476
+D+ LP AS + I + G
Sbjct: 266 --------------QTDHAKLPLQRDASRPQTKQADI--------------------VRG 291
Query: 477 QSLLHGQLIPTTGPVRINT-ARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRG 535
+S+ P+ P++ T +P +PG E S PP Q + +
Sbjct: 292 ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP--GPAKPPAQPSGLTKPLAQQPGTV 349
Query: 536 RHHSERSQRTQGPSLPATPVFVPV-----PPPPLYPPPPHTLPLPPGV---PPPQFSPQF 587
+ + T+ P+ P P P P P P L PPGV P Q P
Sbjct: 350 KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAK 409
Query: 588 PP----GQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPP 635
PP G P P AP TP VQ IP QA P
Sbjct: 410 PPTQQVGTPKPLAQQPGLQSPAKAPGPTKTP-----VQQPGPGKIPAQQAGP 456
Score = 40.0 bits (92), Expect = 0.020
Identities = 33/105 (31%), Positives = 43/105 (40%), Gaps = 27/105 (25%)
Query: 549 SLPATP--------VFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP 600
SLPA P + + PPP PPPP P PP PPP PP PPP P
Sbjct: 2385 SLPAKPRPFFRSSSLDISAQPPPPPPPPP---PPPPPPPPPP-----PPPLPPPTS---P 2433
Query: 601 PPGFPP-------APANLSTPWVSSGVQTAHSNTIPTTQAPPLSR 638
P P +P +TP + V T + + + P++R
Sbjct: 2434 KPTILPKKKLTVASPVTTATP-LFDAVTTLETTAVLRSNGLPVTR 2477
Score = 38.9 bits (89), Expect = 0.045
Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 12/86 (13%)
Query: 335 QLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIP-----VTSSSTHPAPSISSLTS 389
Q PPPPPP PPP P P + P S + P ++P V S T P ++T+
Sbjct: 2404 QPPPPPPPPPPPPPPPPPPPPPPLPPPTSPK--PTILPKKKLTVASPVTTATPLFDAVTT 2461
Query: 390 NQSSLAPPVSGNP-----SSAPAPVP 410
+++ +G P ++AP PVP
Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPPVP 2487
Score = 38.5 bits (88), Expect = 0.059
Identities = 29/82 (35%), Positives = 37/82 (45%), Gaps = 8/82 (9%)
Query: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVS 617
P PPPP PPPP P PP +PPP SP+ P P +V P P + +
Sbjct: 2407 PPPPPPPPPPPPPPPPPPPPLPPPT-SPK--PTILPKKKLTVASPVTTATPLFDAVTTLE 2463
Query: 618 SGVQTAHSNTIPTTQ----APP 635
+ SN +P T+ APP
Sbjct: 2464 T-TAVLRSNGLPVTRICTTAPP 2484
Score = 35.8 bits (81), Expect = 0.38
Identities = 28/102 (27%), Positives = 36/102 (35%), Gaps = 10/102 (9%)
Query: 535 GRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPP 594
G + +Q PS + +P P P + + P PPP P PP PP
Sbjct: 2364 GETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPP- 2422
Query: 595 AGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPL 636
PPP PP + T + A P T A PL
Sbjct: 2423 -----PPPPLPPPTSPKPTILPKKKLTVAS----PVTTATPL 2455
Score = 35.4 bits (80), Expect = 0.50
Identities = 63/283 (22%), Positives = 103/283 (36%), Gaps = 70/283 (24%)
Query: 889 HRSRNIGSNYPEKLSARDGHN--------QKDNTKSKEKESENAPGDGKGNKHKKHRKRR 940
HR + + S++P K S R K T + + PG K K R
Sbjct: 82 HRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSR 141
Query: 941 KGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKS 1000
+L E + S P + E ++L + S + + P D S + S
Sbjct: 142 T----------DLKEEHKSSMMPGFLSE--VNALSAVSSVVN----KFNPFDLISDSEAS 185
Query: 1001 VSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIK 1060
E K+++ K +G K E I+KP Q +++ P +P
Sbjct: 186 QEETTKKQKVVQKEQG-------------KPEGIIKPPLQQQPPKPIPKQQGPGRDPL-- 230
Query: 1061 KAKEETPKTDNTKSSSSSQKDEKI--------------TGTPRKAHSKSAKEHQETKP-- 1104
+ D T S SSQ+ EKI T TP+ H+K + ++P
Sbjct: 231 -------QQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQT 283
Query: 1105 -----VKEEKVKKDYSKDVKS--EKLTTKEEKAKKP-NEKNKP 1139
V+ E VK K ++ T + A++P +EK++P
Sbjct: 284 KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP 326
Score = 35.0 bits (79), Expect = 0.66
Identities = 51/222 (22%), Positives = 86/222 (38%), Gaps = 22/222 (9%)
Query: 1075 SSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPN 1134
SS K + T A SKS+ + Q+T P K+ K+D SK + +K K+P
Sbjct: 655 SSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKK---PPPLVKQPT 711
Query: 1135 EKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRT 1194
P + + + K S + K V + KP + ++P T+ + +
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVAD-DKPKQPKMVKPTTDLVSSS 770
Query: 1195 PEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRK 1254
K + P+ K++ E + + +++ +PS+ T KV K R
Sbjct: 771 SATTKPDI--PSSKVQSQAE---EKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR-- 823
Query: 1255 VTGTEGSSSTLVDYTSTSSTGG-----SPVRKSEE--KTDTK 1289
S S ++ + SS PV+K EE K TK
Sbjct: 824 ----PASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTK 861
Score = 32.7 bits (73), Expect = 3.3
Identities = 79/334 (23%), Positives = 110/334 (32%), Gaps = 77/334 (23%)
Query: 333 RKQLPPPPPPIPPPRPLIQRNLQPLMR-SPISRQQDPLMIPVTSSSTHPAPSISSLTSNQ 391
++ L P P PP PL++ QP + SP ++ + P P S + PAP ++
Sbjct: 691 KQDLSKAPEPKKPP-PLVK---QPTLHGSPSAKAKQP---PEADSLSKPAPPKEPSVPSE 743
Query: 392 SSLAPPVSGNP--------------SSAPAPVPDITATVSISVHSEKSDGPFRDS----- 432
AP P SS+ PDI ++ S EK+ P +
Sbjct: 744 QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPS 803
Query: 433 -------------DNKILPAAALASE--HSKGTSSIAITALMEEKGY-QVPVLGTPSLLG 476
D+K +P A S+ G SS E KG QV +
Sbjct: 804 QSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSS-------ESKGQKQVDPVQKKEEPK 856
Query: 477 QSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYR-SINRG 535
++ P P+ + P G RP G V PQQ + + R S+N G
Sbjct: 857 KAQTKMSPKPDAKPMPKGSPTPPGPRP------TAGQTVPTPQQSPKPQEQSRRFSLNLG 910
Query: 536 R-HHSERSQRTQGPSLPATPVF------------------VPVPPPPLYPPPPHTLPLPP 576
+ +SQ T +F P P P P P
Sbjct: 911 SITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAP 970
Query: 577 GVPPPQFSPQFPPGQPPPA-GYSVPPPGFPPAPA 609
PP P GQ PPA S+P APA
Sbjct: 971 SQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPA 1004
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 91.3 bits (225), Expect = 8e-18
Identities = 146/676 (21%), Positives = 261/676 (38%), Gaps = 109/676 (16%)
Query: 988 DEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDG 1047
D +DA + + ++E K K K K K+K D +++I+K + + G
Sbjct: 16 DIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQD----FDEDDILKELEELSLEAQG 71
Query: 1048 -ERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVK 1106
+ +R + P + +EE D K +K + K +K + KP
Sbjct: 72 IKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKV 131
Query: 1107 EEKVKKDYSKDVKSEKLTTKEE-KAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSM 1165
E D D KL K + KA+K N+K + + K+ E ++ ES
Sbjct: 132 EMYSGSDDDDDF--NKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDE 189
Query: 1166 KISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKD-KISLSAPAKKIKLNRETGK------- 1217
L+ + K + K K P+ E + + KI A K K RE K
Sbjct: 190 SDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAK 249
Query: 1218 --KIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTG 1275
K+ E + K+ K + + K ++E VK KV T TG
Sbjct: 250 LRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKV-------------------TVDTG 290
Query: 1276 GSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKS 1335
P SEEK +T T E +N+ +D + K +K++ E E++ S
Sbjct: 291 VIPA--SEEKAET-----PTAAEDDNEGDKKKKD------KKKKKGEKEEKEKEKKKGPS 337
Query: 1336 TQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNS 1395
+ ++ + + +K + ++ E E+I++
Sbjct: 338 KATVKAMQEALAKLKEEEER---------QKREEEERIKRL------------------- 369
Query: 1396 ASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDK 1455
E+ + K ++ LE+E E++K Q EKE +RL ++G K L++S +EAR +
Sbjct: 370 ---EELEAKRKEEERLEQEKRERKK---QKEKERK-ERLKKEG--KLLTKSQREARARAE 420
Query: 1456 HDSTRASSNKDFTPNRD----KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQ 1511
+ P++D K+ Y+ ++ ++ E E++ + + + G
Sbjct: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV 480
Query: 1512 KNK--------PREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1563
K P EE D G D ++ +S K +K + K EE + ++
Sbjct: 481 PEKEETPPPVEPEEEEDTEDAGL-DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEE 539
Query: 1564 NPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQ-IDKSTVKPKPQLSHSS 1622
+D E E ES G++ + + +V E+ +G+ +DK KP ++S S
Sbjct: 540 EEEEDEESEE-EEEEEGESEGSE----GDEEDEKVSDEKDSGKTLDK---KPSKEMSSDS 591
Query: 1623 RLSSDLTRETDEAAFE 1638
SD R +E A++
Sbjct: 592 EYDSDDDRTKEERAYD 607
Score = 87.4 bits (215), Expect = 1e-16
Identities = 138/619 (22%), Positives = 247/619 (39%), Gaps = 70/619 (11%)
Query: 922 ENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRD 981
E P KG K KK +K++ +E + L E S E G++ ++ +++ V P+ +
Sbjct: 34 EQEPQKSKGKK-KKEKKKQDFDEDD-----ILKELEELSLEAQGIKADR-ETVAVKPTEN 86
Query: 982 DATPV--RDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKN----DGSAVSKKEN-I 1034
+ +D+ + +S + D E + +K KT + GS N +
Sbjct: 87 NEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKL 146
Query: 1035 VKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSK 1094
K AKG +K + + + S E KK KE + N+ S + DE + K
Sbjct: 147 PKKAKGKAQKSNKKWDGSEEDEDNSKKIKERS--RINSSGESGDESDEFLQSR------K 198
Query: 1095 SAKEHQETKP---VKEEKVKKDYS---KDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK-- 1146
K++Q+ KP ++ D S K V +K KE + KK +E+ L EK
Sbjct: 199 GQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEE 258
Query: 1147 ----RKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL 1202
+K ++++K + FE ++K SK+ V V P+ + K E T D K
Sbjct: 259 LETGKKDQSKQKESQRKFEEETVK-SKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD 317
Query: 1203 SAPAKKIKLNRETGKKIG-STENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGS 1261
K K +E KK G S + +E KL+ + K+E+ + R + +
Sbjct: 318 KKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRK 377
Query: 1262 SSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQ-----V 1316
++ +K +E+ + + K + + + A AE + ++Q V
Sbjct: 378 EEERLEQEKRERKK----QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEV 433
Query: 1317 PQ--SKWDKDDFESEEEDVKSTQPISS--VGKPASVIKNVSTKPSNIVKYPEKESEPSEK 1372
P S K +++ K Q + S V + + V + PEKE P
Sbjct: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV---PEKEETPPPV 490
Query: 1373 IQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKES--N 1430
+ +D + ++ E K + + KENPE+ + + E+E +
Sbjct: 491 EPEEEEDTEDAGLDDW---EAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547
Query: 1431 LDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTD--YDT--------R 1480
+ E+G + ++ + SD+ DS + K P+++ +D YD+ R
Sbjct: 548 EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKK---PSKEMSSDSEYDSDDDRTKEER 604
Query: 1481 EYSSSKRRDEKNELTRRKD 1499
Y +KRR EK L K+
Sbjct: 605 AYDKAKRRIEKRRLEHSKN 623
Score = 78.2 bits (191), Expect = 7e-14
Identities = 151/730 (20%), Positives = 261/730 (35%), Gaps = 148/730 (20%)
Query: 1068 KTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVK----EEKVKKDYSKD-----V 1118
K KS S++ D + + A + QE + K +EK K+D+ +D +
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 1119 KSEKLTTKEEKAKKPNEKNKPLDNKGE----KRKRKTEEKGVDKDFESSSMKISKLEVTE 1174
+ L + KA + KP +N E K K+K +KG + F+ + E E
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS-----EELE 117
Query: 1175 IVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEK 1234
K+ +P E + + D + K K + K GS E+ N+K
Sbjct: 118 DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSK----- 172
Query: 1235 LESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIK 1294
K+K + R +G G S D S G +K + K
Sbjct: 173 -----------KIKERSRINSSGESGDES---DEFLQSRKG--------QKKNQKNKPGP 210
Query: 1295 TMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVST 1354
+E N D+ A + + V Q K +K + E ++ D + +
Sbjct: 211 NIESGNEDDDASFK----IKTVAQKKAEKKERERKKRDEEKAK----------------- 249
Query: 1355 KPSNIVKYPEKES-EPSEKIQKFTKDVSHEIIQHEVKSSKN------SASSEKGKTKDRD 1407
+ K EKE E +K Q K+ + + VKS AS EK +T
Sbjct: 250 ----LRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAA 305
Query: 1408 YSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDF 1467
E + +K K + EKE ++ ++G K+ ++ +EA K + R ++
Sbjct: 306 EDDNEGDKKKKDKKKKKGEKEEK-EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364
Query: 1468 TPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTG 1527
R ++ + +E + EK E ++K+ + + G K + +R+ +
Sbjct: 365 RIKRLEELEAKRKE--EERLEQEKRERKKQKEKERKERLKKEG-KLLTKSQREARARAEA 421
Query: 1528 DSKKSNSS----PSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARN----- 1578
K + PS+D P KRP E K K P + K V E+
Sbjct: 422 TLKLLQAQGVEVPSKDSLPK--------KRPIYEDKKRKKIPQQLESKEVSESMELCAAV 473
Query: 1579 --------NKESSGNKLLYILNPPETQVEKEQITGQI-----DKSTVKPKPQLSHSSRLS 1625
KE + PP + E+E+ T + + + +++
Sbjct: 474 EVMEQGVPEKEET---------PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVH 524
Query: 1626 SDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQV 1685
++ +E E + E D ES +EE S D +D+ V K+S T
Sbjct: 525 IEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTL----- 579
Query: 1686 GISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKK-EKKKHKKHKKH 1744
PS+ SS S +S D + K+++ +K K + K+
Sbjct: 580 -----------DKKPSK-----------EMSSDSEYDSDDDRTKEERAYDKAKRRIEKRR 617
Query: 1745 KKHKKHAGTE 1754
+H K+ TE
Sbjct: 618 LEHSKNVNTE 627
Score = 69.7 bits (169), Expect = 2e-11
Identities = 115/474 (24%), Positives = 183/474 (38%), Gaps = 78/474 (16%)
Query: 895 GSNYPEKLSARDGHNQKDNTKSKEK---ESENAPGDG--------KGNKHKKHRKRRKGE 943
G E L +R G QK N K+K ES N D + KK R+R+K +
Sbjct: 187 GDESDEFLQSRKG--QKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRD 244
Query: 944 ESEGFLNP----ELLETSRKSR----------EPTGVEENKTDSLFVLPSRDDATPVRDE 989
E + L E LET +K + E V+ T V+P+ ++ +
Sbjct: 245 EEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKA---ET 301
Query: 990 PMDAESITFKSVSEKDKRERDKPKAKG-----DKTKRKNDGSAVSK--KENIVKPAKGPQ 1042
P AE +E DK+++DK K KG +K K+K A K +E + K + +
Sbjct: 302 PTAAEDD-----NEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356
Query: 1043 EKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQET 1102
+ E ER R E K KEE + + K QK+++ +K K +E
Sbjct: 357 RQKREEEERIKRLEELEAKRKEE-ERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREA 415
Query: 1103 KPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL--DNKGEKRKRKTEEKGVDKDF 1160
+ E +K ++ V E +K K +P+ D K +K ++ E K V +
Sbjct: 416 RARAEATLKLLQAQGV--------EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESM 467
Query: 1161 E-SSSMKI------SKLEVTEIVKPSPKRKME----PDTEKMDRTPEKDKISLSAPAKKI 1209
E +++++ K E V+P + E D E M E +K+ + ++
Sbjct: 468 ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527
Query: 1210 KLNRETGKKIGSTENISNTKEPSEKLESTS---------SKVKQEKVKGKVRRKVTGTEG 1260
K N E ++ E E E+ E S KV EK GK K E
Sbjct: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM 587
Query: 1261 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMI 1314
SS + D + K++ + + +R +E N NT II +
Sbjct: 588 SSDSEYDSDDDRTKEERAYDKAKRRIEKRR-----LEHSKNVNTEKLRAPIICV 636
Score = 67.4 bits (163), Expect = 1e-10
Identities = 85/410 (20%), Positives = 148/410 (36%), Gaps = 68/410 (16%)
Query: 1393 KNSASSEKGKTKDRDYSVLEKE--------NPEKRKNSTQPEKESNLDRLNEQGNFKSLS 1444
K SE D D L E E +K+ + +KE +E K L
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
Query: 1445 QSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRN 1504
+ S EA+ T A P + + ++ +++ ++ +K +
Sbjct: 64 ELSLEAQGIKADRETVAVK-----PTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELED 118
Query: 1505 KDSASGQKNKPREE-----------RDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR 1553
KDS S + KP+ E LPKK G ++KSN + D+ +K+
Sbjct: 119 KDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN-----SKK 173
Query: 1554 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1613
E ++ D L++R GQ K
Sbjct: 174 IKERSRINSSGESGDESDEFLQSRK--------------------------GQKKNQKNK 207
Query: 1614 PKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKA 1673
P P + + E D+A+F+ ++ ++ KE E + K + + K
Sbjct: 208 PGPNIESGN--------EDDDASFKI---KTVAQKKAEKKERERKKRDEEKAKLRKL-KE 255
Query: 1674 KESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSAS-SAESQDSKKKKKK 1732
KE L+T Q +Q S+ +G S + + +A D++ KKK
Sbjct: 256 KEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKK 315
Query: 1733 KEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEK 1782
K+KKK K K+ K+ +K G K+ + K K ++ + K +E+E+
Sbjct: 316 KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEER 365
Score = 66.6 bits (161), Expect = 2e-10
Identities = 111/599 (18%), Positives = 226/599 (37%), Gaps = 82/599 (13%)
Query: 1213 RETGKKIGSTENISNTKEPSEKLESTSSKVKQE--KVKGKVRRKVTGTEGSSSTLVDYTS 1270
++ K ST++ + + ++E + +QE K KGK +++ + ++
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
Query: 1271 TSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEE 1330
S + K D + +K E + T+ + QS D D E E+
Sbjct: 64 ELSLEAQGI-----KADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELED 118
Query: 1331 EDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVK 1390
+D KS + KP + + S + K P+K ++K K D S E + K
Sbjct: 119 KDSKSKK----TAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNK-KWDGSEEDEDNSKK 173
Query: 1391 SSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEA 1450
+ S + G++ D L+ +K+ +P ++ +FK + + K+A
Sbjct: 174 IKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKA 233
Query: 1451 RTSDKHDSTRASSNKDFTPNRDK------KTDYDTREYSSSKRRDE--KNELT------- 1495
++ R ++K K D ++ S K +E K+++T
Sbjct: 234 EKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIP 293
Query: 1496 ---RRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSS--PSRDRKPHDHKATYD 1550
+ ++P+ +D G K K +++ KKG + K+ PS+ +A
Sbjct: 294 ASEEKAETPTAAEDDNEGDKKKKDKKK---KKGEKEEKEKEKKKGPSKATVKAMQEALAK 350
Query: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
K E K ++ K E+ LEA+ +E +L + Q EKE+ K
Sbjct: 351 LKEEEERQKREEEERIKRLEE--LEAKRKEEE---RLEQEKRERKKQKEKER------KE 399
Query: 1611 TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK----EEESSGNISKDLK 1666
+K + +L S+ + E + E S+ ++ K E++ I + L+
Sbjct: 400 RLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
Query: 1667 DKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDS 1726
K V ++ E V++ G+ + + P V P + + AS E++
Sbjct: 460 SKEVSESMELCAAVEVMEQGVPEKEE-TPPPVEPEEEEDTEDAGLDDWEAMASDEETE-- 516
Query: 1727 KKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQ 1785
++E ++ H K+ ++ +++E+E+E+D++
Sbjct: 517 -----------------------------KVEGNKVHIEVKENPEEEEEEEEEEEEDEE 546
Score = 60.5 bits (145), Expect = 1e-08
Identities = 91/461 (19%), Positives = 189/461 (40%), Gaps = 52/461 (11%)
Query: 1320 KWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD 1379
K K+ E +D +++ + A K + S K EK+ + ++ D
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDE-----DD 57
Query: 1380 VSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGN 1439
+ E+ + +++ A E K + + E + +K+K + +K+S D +E+
Sbjct: 58 ILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE 117
Query: 1440 FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD 1499
K SK +T+ + S+ D N+ K + S+ K + + K
Sbjct: 118 DKD----SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKK 173
Query: 1500 SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETK 1559
R++ ++SG+ +E +KG ++K+ P+ + D A++ K T
Sbjct: 174 IKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIK-----TV 228
Query: 1560 SVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQI-TGQIDKSTVKPKPQL 1618
+ K K+RE+ + R+ +++ KL EKE++ TG+ D+S K +
Sbjct: 229 AQKKAEKKERER---KKRDEEKAKLRKLK----------EKEELETGKKDQSKQKESQRK 275
Query: 1619 SHSSRLSSDLTRET------DEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1672
+ S +T +T +E A P E D+E + K+++ K+ K+K +K
Sbjct: 276 FEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG-EKEEKEKEKKK 334
Query: 1673 AKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKK 1732
S T +Q +++ + Q R E ++K+K+++
Sbjct: 335 GP-SKATVKAMQEALAKLKEEEE-------------RQKREEEERIKRLEELEAKRKEEE 380
Query: 1733 K---EKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKS 1770
+ EK++ KK K+ ++ ++ L KSQ+ + ++
Sbjct: 381 RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421
Score = 42.4 bits (98), Expect = 0.004
Identities = 45/191 (23%), Positives = 82/191 (42%), Gaps = 8/191 (4%)
Query: 1609 KSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGN--ISKDLK 1666
KS K K + D+ +E +E + E ++D E+ V+VK E++ SKD K
Sbjct: 39 KSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRET-VAVKPTENNEEEFTSKDKK 97
Query: 1667 DKIVEKAKESLDT--AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQ 1724
K + K+S D + ++ S+++ + P V + + A+
Sbjct: 98 KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKS 157
Query: 1725 DSKKKKKKKEKKKHKKHKKHKKHKK--HAGTEV-ELEKSQKHKHKKKKSKKNKDKEKEKE 1781
+ K ++++ KK K+ + +G E E +S+K + K +K+K + E E
Sbjct: 158 NKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNE 217
Query: 1782 KDDQKVKSVTV 1792
DD K TV
Sbjct: 218 DDDASFKIKTV 228
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 84.7 bits (208), Expect = 7e-16
Identities = 203/1261 (16%), Positives = 449/1261 (35%), Gaps = 156/1261 (12%)
Query: 638 REEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERR-RSFSRSKSPYSGSSYS 696
R+E ++Q+RL+ E++ + K +E +E E ++ Q+ERR + R +
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEER----REQQEERREQQERREQQEERREQQLRREQEE 345
Query: 697 RSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRS 756
R + + R + R R RR + R + R
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 757 RSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDM-------- 808
+ R R + R Q R + +R+ + E ER RE D
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 809 -KAYYGRSVDFRDPFEKERYREW----ERKYREWYEKYYKGYAAGAQPRPSANRENFSPE 863
R + E+ER W E + RE E+ + + R + E
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 864 RFLPLNIRNSPFTRG----RREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEK 919
L +R+ R RRE + + + + E+ R+ ++D +E+
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLL--KREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 920 ESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPS 979
E K + ++ +R K EE E E E K EP EE + L
Sbjct: 584 ERRQQRL--KREQEERLEQRLKREEVERLEQEERREQRLKREEP---EEERRQQLLKSEE 638
Query: 980 RDDATP--VRDEPMDAESITFKSVSEKD------KRERDKPKAKGDKTKRKNDGSAVSKK 1031
+++ +R E + K E++ KRE ++ + + + + + + + K
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 1032 ENIVKPAKGPQEKVDGERER---SPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1088
I K + + D + + PR + ++ +E+ K +S Q++E+
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER----- 753
Query: 1089 RKAHSKSAKEHQETKPV----KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNK------ 1138
AH + +E Q EEK ++ + L + E+ + E+ +
Sbjct: 754 --AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811
Query: 1139 PLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKD 1198
P + + E+R+R+ E+ + F ++ + E + ++ E + + +D
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 1199 K---------------ISLSAPA------KKIKLNRETGKKIGSTENISNTKEPSEKLES 1237
+ + PA K+ +L +E +++ E ++ E+
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931
Query: 1238 TSSKVKQEKV------KGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRT 1291
+++QE+ + K RR+ + + G P ++ ++ + K
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 1292 VIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKN 1351
+ +++ + + + KD+ + EEE + +
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE-------------- 1037
Query: 1352 VSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVL 1411
+ ++ E++ E++Q+ E + E + ++ E+ K+ +
Sbjct: 1038 ---REKRRLQERERQYREEEELQQ-----EEEQLLGEERETRRRQELERQYRKEEELQQE 1089
Query: 1412 E----KENPEKRKNST-----------QPEKESNLDRLNEQGNFKSLSQSSKEARTSDKH 1456
E +E PEKR+ Q E+E L E+ + L + +E +
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Query: 1457 DSTRASSNKDFTPNRDKKTDYDTREYSSSKR----RDEKNELTRRKDSPSRNKDSASGQK 1512
+ + ++ + Y E + R+E+ + + ++ R ++ QK
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209
Query: 1513 NKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDRE-- 1570
K R RD ++ K P ++ D+K Y R NE+ + ++ + +DR+
Sbjct: 1210 RKQRY-RDEDQRS---DLKWQWEPEKENAVRDNKV-YCKGRENEQFRQLEDSQLRDRQSQ 1264
Query: 1571 ---KHVLEARNNKESSGNKLLYILN----PPETQVEKEQI--TGQIDKSTVKPKPQLSHS 1621
+H+L + ++ + + P E Q+E+E+ + D+ + + K QL
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK-QLLRE 1323
Query: 1622 SRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKD-------------- 1667
R +ETD E + + E ++E ++L+
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383
Query: 1668 KIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSK 1727
+ E+ ++ L ++ Q Q R + + +
Sbjct: 1384 RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQE 1443
Query: 1728 KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1787
+++K E+++ + ++H+K ++ E E+ Q H+ ++ + ++++ +++ D+K
Sbjct: 1444 RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Query: 1788 K 1788
+
Sbjct: 1504 R 1504
Score = 77.8 bits (190), Expect = 9e-14
Identities = 177/1174 (15%), Positives = 437/1174 (37%), Gaps = 131/1174 (11%)
Query: 638 REEFYREQRRLKEEEKKKSKLD--EFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSY 695
+EE + QR L+EEE++ KL+ E + +E + +++++E++ + +
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR-RKQEEERREQQE 319
Query: 696 SRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHR 755
R + + R + R + R RR + R R R
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 756 SRS--RSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETE--REYFNRYREVPPPYDMKAY 811
+ R RR R Q R Q + + E + RE R + ++ K
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 812 YGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIR 871
R + R E+E R+W ++ E E++ + + + ++E ER+L L
Sbjct: 440 QERR-EQRLKREQEERRDWLKREEE-TERHEQ---ERRKQQLKRDQEEERRERWLKLEEE 494
Query: 872 NSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGN 931
+ RRE + R+ +++ +++E E +
Sbjct: 495 ERREQQERREQQL-------------------RREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 932 KHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPM 991
+ + + + E+ + LE R+ + +E + D L R+E
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL----------KREEER 585
Query: 992 DAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERER 1051
+ + ++++ ER + + K ++ +R ++ +P + ++++ E+
Sbjct: 586 RQQRL------KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 1052 SPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVK 1111
R + +++ ++E + +++E++ ++ H + +E + + +E+ +
Sbjct: 640 EERRQQQLRREQQER----REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Query: 1112 KDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLE 1171
+ S+ K + E A++ ++P +G++R+++ EEK ++ S+L+
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--------SELQ 747
Query: 1172 VTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEP 1231
E + R+ + + ++ D T + A K + + + E
Sbjct: 748 WQE--EERAHRQQQEEEQRRDFTWQ-----WQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 1232 SEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRT 1291
E+ + + +E+ K + RR+ E L EE+ +R
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQRREREKELQFL----------------EEEEQLQRRE 844
Query: 1292 VIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKN 1351
+ ++E + E Q KW ++ EEE + + KPA ++
Sbjct: 845 RAQQLQEEEDGLQEDQERRRSQEQRRDQKW---RWQLEEERKRRRHTL--YAKPA--LQE 897
Query: 1352 VSTKPSNIVKYPEKESEPSEKIQKFTKD------VSHEIIQHEVKSSKNSASSEKGKTKD 1405
K +++ E+E + E+ ++ ++ ++ Q E + + + + ++
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 1406 RDYSVLEK-ENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSN 1464
R Y +K + E++ +PEK +R + + L Q ++ ++ R
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 1465 KDFTPNRDKKTDYD--TREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLP 1522
+ + + + + + RE +R E+ R ++ + ++ G++ + R ++L
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077
Query: 1523 KKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKES 1582
++ + + R+ + + +R E + ++ + E+ +L K
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKR-----RRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 1583 SGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEP--- 1639
E Q E+EQ+ ++ + + +L R +L +E ++ E
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLR--EEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Query: 1640 -------DYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQS 1692
Y E + K+ + DLK + + + ++ V G Q
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 1693 HSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAG 1752
+ S+ Q H +++E+ + ++ ++ ++ +H
Sbjct: 1251 R---QLEDSQLRDRQSQQDLQHLLG-------------EQQERDREQERRRWQQRDRHFP 1294
Query: 1753 TEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQK 1786
E +LE+ ++ + K++ K ++K+ +E+ ++K
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Score = 75.1 bits (183), Expect = 6e-13
Identities = 143/971 (14%), Positives = 371/971 (38%), Gaps = 118/971 (12%)
Query: 900 EKLSARDGHNQKDNTKSKEKESEN-APGDGKGNKHKKHRKRRKGEESEGFLNPELLETSR 958
EK + DG + +E++ P D + + R+R+K +E E EL E
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER----ELAEGEE 153
Query: 959 KSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDK 1018
+S + +E+ RDE + + ++ E+ E KG +
Sbjct: 154 QSEKQERLEQRDRQR-------------RDEELWRQRQEWQEREERRAEEEQLQSCKGHE 200
Query: 1019 TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPR------------SEPPIKKAKEET 1066
T+ D + ++E + KG +EK RER R E ++K +E+
Sbjct: 201 TEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260
Query: 1067 PKTDNTKSSSSSQKDEKITGTPRK--AHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLT 1124
+ + + +++E++ R+ + +E Q+ + +E+++++ ++ + ++
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 1125 TKEEKAKK-PNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRK 1183
+E++ ++ E+ + + E+ +R+ ++ +++ E ++ + + E + +R+
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 1184 MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVK 1243
+ E+ R ++ + ++ +L RE + ++ E K +
Sbjct: 381 QQLRREQQLRREQQLRREQQL-RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 1244 QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDN 1303
QE+ + +++R+ + K +++ + + +K EE +
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 1304 TAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISS---------------------- 1341
E ++ Q + + + +EE+ + Q + S
Sbjct: 500 QERREQ---QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 1342 ----VGKPASVIKNVSTKPSNIVKYPEK------ESEPSEKIQKFTKDVSHEIIQHEVKS 1391
+ + + + ++K E+ + E E++++ K E ++ E +
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 1392 SKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEAR 1451
+ E + + + E++ +++ + ++E RL + + L Q K
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676
Query: 1452 TSDKHDSTRASSNKDFTPNRDK----------KTDYDTRE---YS------SSKRRDEKN 1492
++ + A ++ R K +++ D R+ YS +RR E+
Sbjct: 677 EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Query: 1493 ELTRRKDSPS--RNKDSASGQKNKPREERDL-------PKKGTGDSKKSNSSPSRDRKPH 1543
E RR++S + ++ A Q+ + + RD K G + S P R+++
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER 796
Query: 1544 DHKATYDTKR-----PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPE--T 1596
+A +R P EE K + ++REK + ++ + L E
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 1597 QVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEE 1656
Q ++E+ Q + K + QL + R +P E + ++EEE
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERK------RRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 1657 SSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSS 1716
+ K + E+ ++ + + Q + R + R +
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQL--------QQEEEQLLREEREKRRRQERERQYRK 962
Query: 1717 SASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDK 1776
+ ++ ++ +++++ ++ KK+++ ++ E +L + ++ K ++++ ++ K
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 1777 EKEKEKDDQKV 1787
+ E +++++++
Sbjct: 1023 KDELQQEEEQL 1033
Score = 75.1 bits (183), Expect = 6e-13
Identities = 184/1167 (15%), Positives = 426/1167 (36%), Gaps = 120/1167 (10%)
Query: 638 REEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSR 697
R+E+ + R EEE+ +S T +F E ++ E RR K R
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ---QRRER 233
Query: 698 SSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSR 757
+ + R R + + P R + + R R R
Sbjct: 234 QDRVFQEEEEKEWRKR--ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ---ELRR 288
Query: 758 SRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVD 817
R ++ R Q R Q +R Q E RE R
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERRE--QQEERREQQER------------------- 327
Query: 818 FRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTR 877
R+ E+ R ++ R+ E E+ + + RE R L R R
Sbjct: 328 -REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR-REQQLRR 385
Query: 878 G---RREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHK 934
RRE + + R ++L R+ +++ +E+E E + + +
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQL-RREQQLRREQQLRREQEEERHEQKHE-QERR 443
Query: 935 KHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAE 994
+ R +R+ EE +L E ET R +E + L RD R+ + E
Sbjct: 444 EQRLKREQEERRDWLKRE-EETERHE------QERRKQQL----KRDQEEERRERWLKLE 492
Query: 995 SITFKSVSEKDKRE--RDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERS 1052
+ E+ +++ R++ + + + KR+ + + ++ + + QE+ RE+
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE---RREQL 549
Query: 1053 PRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKK 1112
+ E +K E+ + K ++D+ + + + +E +E E+++K+
Sbjct: 550 LKREE--EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER---LEQRLKR 604
Query: 1113 DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEV 1172
+ + ++ E+ + K ++P E+ + K E+++ + +++ + E ++ + E
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664
Query: 1173 TEIVKPSPKRKMEPDTEKMDRTPE-----KDKISLSAPAKKIKLNRETGKKIGSTENISN 1227
E ++ KR+ E + + + E +++I P + +L E + S
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR------QSK 718
Query: 1228 TKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1287
K E + +QE+ + + ++ E + + ++EEK++
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 1288 TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1347
R + ++ + + + F EEE+ + +
Sbjct: 779 RGRQRLSARPPLREQRER-------QLRAEERQQREQRFLPEEEEKEQRR---------- 821
Query: 1348 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRD 1407
+ EKE + E+ ++ + + +Q E + + + + RD
Sbjct: 822 ----------RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 1408 YS-VLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKD 1466
+ E KR+ T K + ++L ++ L + +E + ++ R +
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL--LQEEEEELQREEREKRRRQEQERQ 929
Query: 1467 FTPNRDKKTDYD--TREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKK 1524
+ + + + RE +RR E+ R+ + ++ G++ + R ++ KK
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 1525 GTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSG 1584
+ + R+ + + +R E + K+ + E+ +L K
Sbjct: 990 YREEEELQQEEEQLLREEREKR-----RRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Query: 1585 NKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDE-AAFEPDYNE 1643
+ E Q E+EQ+ G ++ + + +L R +L +E ++ EP+
Sbjct: 1045 ERERQYREEEELQQEEEQLLG--EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR 1102
Query: 1644 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1703
+EEE + L+++ ++ ++ L+ + + + + R
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162
Query: 1704 HSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK-SQK 1762
Q R + ++ + ++++EK++ ++ +++++ + E++ +K Q+
Sbjct: 1163 RQELERQYREE----EELQQEEEQLLREEQEKRRQERERQYREEE-----ELQRQKRKQR 1213
Query: 1763 HKHKKKKS--KKNKDKEKEKEKDDQKV 1787
++ + ++S K + EKE D KV
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Score = 73.2 bits (178), Expect = 2e-12
Identities = 194/1287 (15%), Positives = 485/1287 (37%), Gaps = 163/1287 (12%)
Query: 636 LSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKS------- 688
L RE+ R ++RLK EE+++ + +E E + ++E+ ++ R KS
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706
Query: 689 PYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRN----- 743
+ +R S YS+ R + R + R S + R R +
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 744 ----YRSRSRSHGYHRSRSRSPPYR-------RYHSRSRSPQAFRGQSPNKRNVPQGETE 792
+++ +S + S PP R R R + Q F + K + E
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 793 REYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYR---EWERKYREWY-----EKYYKG 844
RE ++ E + + + D ++++ R + +R+ ++W E+ +
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 845 YAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRS-----------RN 893
+ A+P A +E E+ L L R RE + R
Sbjct: 887 HTLYAKP---ALQEQLRKEQQL-LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Query: 894 IGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPEL 953
+ EK ++ Q K +++ E G+ + ++ R+++ EE E L E
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE--LQQEE 1000
Query: 954 LETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPK 1013
+ R+ RE +E + + D +E + E + + E++++ R++ +
Sbjct: 1001 EQLLREEREKRRRQEWERQY-----RKKDELQQEEEQLLREEREKRRLQERERQYREEEE 1055
Query: 1014 AKGDK---------TKRKNDGSAVSKKENIVKPAKG------PQEKVDGERERSPRSEPP 1058
+ ++ T+R+ + +KE ++ + P+++ ERER R E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 1059 IKKAKEETPKTDNTK------------SSSSSQKDEKITGTPRKAHSKSAKEHQETKPVK 1106
+++ +E+ + + K Q++E++ R+ K ++ E + +
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL---REEPEKRRRQELERQYRE 1172
Query: 1107 EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMK 1166
EE+++++ + ++ E+ ++E+ ++ E+ + L + K++ + E++ D ++ K
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEE-LQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Query: 1167 ISKLEVTEIV---KPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRET------GK 1217
+ + ++ + + + + D++ DR ++D L ++ +E +
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR 1291
Query: 1218 KIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGS 1277
E + ++ K S+ +++ ++ + K E +
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Query: 1278 PVRKSEEKTDTKRTVIKTMEE-------------YNNDNTAPAEDVIIMIQV--PQSKWD 1322
P+R+ E + ++ E+ + E+ + Q Q + D
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 1323 KD-DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKI---QKFTK 1378
+D F EE+ + + + ++ + + + + E K ++ +
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 1379 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQG 1438
+ + + + + K ++ + ++RD E+E + E+E L R Q
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531
Query: 1439 NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRK 1498
F Q ++ R ++ R ++ F + + + ++ S R E++ R +
Sbjct: 1532 KFL---QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS----RQERDRKFRLE 1584
Query: 1499 DSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTK------ 1552
+ R ++ Q+ K E+ ++ G + RDRK + + +
Sbjct: 1585 EQKVRRQE----QERKFMEDEQQLRRQEGQQQLRQE---RDRKFREDEQLLQEREEQQLH 1637
Query: 1553 RPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQV------------EK 1600
R + K +++ P R++ + R++++ + +L E Q E+
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 1601 EQITGQ------IDKSTVKPKPQLSHSSRLSSDLTRETDEAAF--EPDYNESDSESNVSV 1652
+Q+ Q + + + +L R L +ET++ + Y + E +
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 1653 -KEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQT 1711
+EE+ +D K + E+ ++ + + R + + R Q
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR-KFREEEQLRQEREEQQLRPQQ 1816
Query: 1712 RS--HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKK 1769
R + + ++ +++ +++ ++++ ++ +K E EL + ++ K ++++
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Query: 1770 SKKNKD-------KEKEKEKDDQKVKS 1789
+K ++ KE+++ + ++KS
Sbjct: 1877 ERKLREEHIRRQQKEEQRHRQVGEIKS 1903
Score = 71.6 bits (174), Expect = 6e-12
Identities = 201/1209 (16%), Positives = 474/1209 (39%), Gaps = 137/1209 (11%)
Query: 636 LSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSY 695
L RE+ R ++RLK EE ++ + +E ++ ++ ++ ++ERR+ +S+
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEE----RREQRLKREEPEEERRQQLLKSE-----EQE 640
Query: 696 SRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHR 755
R + + R + R RR + + + ++R R
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR----ER 696
Query: 756 SRSRSPPYR-RYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGR 814
+SR P ++ + S + + Q+ P K+ + E+E R RE + + R
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756
Query: 815 SVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPE------RFLPL 868
+ E+ R W+ + E E+ + +A R R+ + E RFLP
Sbjct: 757 Q---QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 869 NIRNSPFTRGRREDYVGGQSHRSRNIG-SNYPEKLSARDGHNQKDNTKSKEKESENAPGD 927
R RRE R + + E+L R+ Q + +E +
Sbjct: 814 EEEKEQRRRQRRE--------REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 928 GKGNKHKKHR----KRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDA 983
+ + +K R + RK + P L E RK ++ EE + R++
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL-------QREER 918
Query: 984 TPVRDEPMDAESITFKSVSEKD----KRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAK 1039
R + + + + + +++ + ER+K + + + + + D K+E ++ +
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL--GE 976
Query: 1040 GPQEKVDGERERSPRSEPPIKKAKEETPKTDN------------TKSSSSSQKDEKITGT 1087
P+++ ERE+ R E +++ +E+ + + K Q++E++
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLL-- 1034
Query: 1088 PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKR 1147
R+ K + +E + +EE+++++ + + E+ T + ++ ++ K + L + E+
Sbjct: 1035 -REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 1148 KRKTEEKGVDKDFESSSMKISKL--EVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAP 1205
R+ EK ++ E + +L E ++++ +++ + E+ R E+
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE------VQ 1147
Query: 1206 AKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTL 1265
++ +L RE +K E +E E + +++E+ K + R+ E
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ- 1206
Query: 1266 VDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDD 1325
RK + + +R+ +K E +N D + + +++ +
Sbjct: 1207 -----------RQKRKQRYRDEDQRSDLKWQWEPEKENA--VRDNKVYCKGRENEQFRQL 1253
Query: 1326 FESEEEDVKSTQPISS-VGKPASVIKNVSTK--PSNIVKYPEKE----SEPSEKIQKFTK 1378
+S+ D +S Q + +G+ + + +PE+E E E ++ K
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313
Query: 1379 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEK-ENPEKRKNSTQPEKESNLDRLNEQ 1437
+ + E + K K ++ + + E+ E P +R+ + +E L R EQ
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL-RHQEQ 1372
Query: 1438 GNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRR 1497
G K L + + R + K+ R ++ + R+ K R+E+ +L+R+
Sbjct: 1373 GR-KFLEEEQRLRRQERERKFL-----KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426
Query: 1498 -KDSPSRNKDSASGQKNKPR----EERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTK 1552
+D R ++ ++ + R EE+ L ++ ++ + H+ D K
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK 1486
Query: 1553 RPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQ--ITGQIDKS 1610
EE + + +DR+ E R+ + P +E+EQ Q +
Sbjct: 1487 FLEEEQQL--RRQERDRKFREQELRSQE------------PERKFLEEEQQLHRQQRQRK 1532
Query: 1611 TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNIS------KD 1664
++ + QL R + E + E +S +E + + ++
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 1665 LKDKIVEKAKESLDTAAVVQVGISRNQS-HSSPSVSPSRSHSPSGSQTRSHSSSASSAES 1723
+ K +E ++ Q+ R++ + R Q R E
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR----KFLEE 1648
Query: 1724 QDSKKKKKKKEKKKHKKHKKHKKHKK--HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKE 1781
+ ++++++++ +H + +K ++ ++ G E +L + ++ + +++ ++ + +E+E++
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Query: 1782 --KDDQKVK 1788
+++Q+++
Sbjct: 1709 FLQEEQQLR 1717
Score = 70.9 bits (172), Expect = 1e-11
Identities = 205/1186 (17%), Positives = 433/1186 (36%), Gaps = 171/1186 (14%)
Query: 640 EFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSS 699
+F E+ +L+ E+ + +E D +E E ++ Q++RR R + +
Sbjct: 832 QFLEEEEQLQRRERAQQLQEE--EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 700 YTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSR---------- 749
Y ++ + + R RR + + R YR +
Sbjct: 890 Y----AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945
Query: 750 -SHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDM 808
R + R YR+ + + G+ P KR ERE +YRE +
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR----RQERE--KKYRE-----EE 994
Query: 809 KAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPL 868
+ R+ EK R +EWER+YR+ E Q RE R L
Sbjct: 995 ELQQEEEQLLREEREKRRRQEWERQYRKKDELQ--------QEEEQLLREEREKRR---L 1043
Query: 869 NIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKE--KESENAPG 926
R + R E+ + Q + +G E+ + R ++ K +E +E E
Sbjct: 1044 QERERQY---REEEEL--QQEEEQLLGE---ERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 927 DGKGNKHKKHRKRRKGEESEGFLNPE-LLETSRKSREPTGVEENKTDSLFVLPSRDDATP 985
+ + ++ R+R+ EE E E LL R+ R +E + V +++
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV--QQEEEQL 1153
Query: 986 VRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKV 1045
+R+EP + E+ RE ++ + + ++ R+ QEK
Sbjct: 1154 LREEPEKRR----RQELERQYREEEELQQEEEQLLREE------------------QEKR 1191
Query: 1046 DGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPV 1105
ERER R E +++ K + D + S D K P K ++ V
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRS-----DLKWQWEPEKENA-----------V 1235
Query: 1106 KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNK-GEKRKRKTEEKGVDKDFESSS 1164
++ KV Y K ++E+ E+ + + + L + GE+++R E++ + ++
Sbjct: 1236 RDNKV---YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER--RRWQQRD 1290
Query: 1165 MKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTEN 1224
+ E E R+ + + ++ DR +++K L ++ + +ET +K E
Sbjct: 1291 RHFPEEEQLE-------REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343
Query: 1225 ISNTKEPSE-KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSE 1283
+ +E + + K ++E+++ + + + E + +R E
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403
Query: 1284 EKTDTK-------RTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDD----------F 1326
+ + R + + D E+ + Q + K+ +++ F
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF 1463
Query: 1327 ESEEE--DVKSTQPISSVGKPASVIKNVST--KPSNIVKYPEKESEPSEKIQKFTKDVSH 1382
EE+ + Q + + ++ + K+ E+E E +KF ++
Sbjct: 1464 REEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ 1523
Query: 1383 --------EIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRL 1434
+ +Q E + + ++ + +DR + E+ E+ + ++ RL
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRL 1583
Query: 1435 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDT------------REY 1482
EQ K Q + D+ R + RD+K D R+
Sbjct: 1584 EEQ---KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Query: 1483 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKP 1542
K +E+ +L R++ R + + K REE L ++G + RDRK
Sbjct: 1641 RDRKFLEEEPQLRRQE----REQQLRHDRDRKFREEEQLLQEGEEQQLRRQE---RDRKF 1693
Query: 1543 HDHKATYDTKRPNEETKSVDKNPCKDR---EKHVLEARNNKESSGNKLLYILNPPETQVE 1599
+ + +R E K + + R E+ E ++ + + L +E
Sbjct: 1694 REEEQ--QLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 1600 KEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSG 1659
+EQ+ + ++ ++ + + R L +E +E ++ +++E
Sbjct: 1752 EEQLRPEREEQQLR-RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 1660 NISKDLKDKIVEKAKESLDTAAVVQ-VGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSA 1718
+ +D +E L Q + R++ + R+ +Q +S
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQY--------RAEEQFATQEKSRREEQ 1862
Query: 1719 SSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHK 1764
+ ++ +K+++++E+K ++H + ++ ++ +V KSQ+ K
Sbjct: 1863 ELWQEEE-QKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 64.7 bits (156), Expect = 8e-10
Identities = 198/1196 (16%), Positives = 438/1196 (36%), Gaps = 220/1196 (18%)
Query: 630 TTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSP 689
T A P +E+ +EQ+ L+EEE+ E ++ ++E+RR
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEE-----------------ELQREEREKRR-------- 922
Query: 690 YSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSR 749
+ R Y + R R +
Sbjct: 923 ------------------------------RQEQERQYREEEQLQQEEEQLLREEREK-- 950
Query: 750 SHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMK 809
R + R YR+ + + G+ P KR ERE +YRE + +
Sbjct: 951 ----RRRQERERQYRKDKKLQQKEEQLLGEEPEKRR----RQERE--KKYRE-----EEE 995
Query: 810 AYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLN 869
R+ EK R +EWER+YR+ E Q RE R L
Sbjct: 996 LQQEEEQLLREEREKRRRQEWERQYRKKDEL--------QQEEEQLLREEREKRR---LQ 1044
Query: 870 IRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKE--KESENAPGD 927
R + R E+ + Q + +G E+ + R ++ K +E +E E +
Sbjct: 1045 ERERQY---REEEEL--QQEEEQLLGE---ERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 928 GKGNKHKKHRKRRKGEESEGFLNPE-LLETSRKSREPTGVEENKTDSLFVLPSRDDATPV 986
+ ++ R+R+ EE E E LL R+ R +E + V +++ +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV--QQEEEQLL 1154
Query: 987 RDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVD 1046
R+EP + E+ RE ++ + + ++ R+ QEK
Sbjct: 1155 REEPEKRR----RQELERQYREEEELQQEEEQLLREE------------------QEKRR 1192
Query: 1047 GERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVK 1106
ERER R E +++ K + D + S D K P K ++ V+
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRS-----DLKWQWEPEKENA-----------VR 1236
Query: 1107 EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDN-KGEKRKRKTEEKGVDKDFESSSM 1165
+ KV Y K ++E+ E+ + + + L + GE+++R E++ + ++
Sbjct: 1237 DNKV---YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE--RRRWQQRDR 1291
Query: 1166 KISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENI 1225
+ E E R+ + + ++ DR +++K L ++ + +ET +K E +
Sbjct: 1292 HFPEEEQLE-------REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL 1344
Query: 1226 SNTKEPSE-KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEE 1284
+E + + K ++E+++ + + G + E+
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQ-----------------------GRKFLEEEQ 1381
Query: 1285 KTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGK 1344
+ + K ++E E + + + + ++ +E D K + V +
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 1345 PASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTK 1404
K + + + K E + +Q+ + H + + K ++ + +
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH----RQERDRKFLEEEQQLRRQ 1497
Query: 1405 DRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSN 1464
+RD E+E + E+E L R Q F Q ++ R ++ R +
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF---LQEEQQLRRQERGQQRRQDRD 1554
Query: 1465 KDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKK 1524
+ F + + + ++ S R E++ R ++ R ++ Q+ K E+ ++
Sbjct: 1555 RKFREEEQLRQEREEQQLS----RQERDRKFRLEEQKVRRQE----QERKFMEDEQQLRR 1606
Query: 1525 GTGDSKKSNSSPSRDRKPHDHKATYDTK------RPNEETKSVDKNPCKDREKHVLEARN 1578
G + RDRK + + + R + K +++ P R++ + R+
Sbjct: 1607 QEGQQQLRQ---ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH 1663
Query: 1579 NKESSGNKLLYILNPPETQ------------VEKEQITGQ------IDKSTVKPKPQLSH 1620
+++ + +L E Q E++Q+ Q + + + +L
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER 1723
Query: 1621 SSRLSSDLTRETDEAAF--EPDYNESDSESNV-SVKEEESSGNISKDLKDKIVEKAKESL 1677
R L +ET++ + Y + E + +EE+ +D K + E+ ++
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783
Query: 1678 DTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTR--SHSSSASSAESQDSKKKKKKKEK 1735
+ ++ S + + R Q R + + ++ +++ +++
Sbjct: 1784 EEQQ-LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842
Query: 1736 KKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKE-KEKEKDDQKVKSV 1790
++++ ++ +K E EL + ++ K ++++ +K +++ + ++K++Q+ + V
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898
Score = 55.8 bits (133), Expect = 4e-07
Identities = 116/775 (14%), Positives = 290/775 (37%), Gaps = 86/775 (11%)
Query: 1036 KPAKGPQEKVDGERERSPRSEPP--IKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHS 1093
+P E+ G+R R R E + + +E++ K + + ++DE++
Sbjct: 123 EPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW-------- 174
Query: 1094 KSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEE 1153
+ +E QE + + E+ + K ++E+ +E+ ++ + L KG + K++
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR---ELLELRRKGREEKQQQRR 231
Query: 1154 KGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNR 1213
+ D+ F+ K + T + K K + E + + E++++ ++ +L R
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR---KLERQELRR 288
Query: 1214 ETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS 1273
E ++ + + ++ K E + ++E+ + + RR+ +
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE 348
Query: 1274 TGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQV--PQSKWDKDDFESEEE 1331
+R+ +E+ ++ + + EE + E + Q + + ++ E+
Sbjct: 349 ---QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 1332 DVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH--------- 1382
++ Q + + + + + + E++ E + Q+ ++
Sbjct: 406 QLRREQQLR---REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 1383 EIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKS 1442
E +HE + K ++ + + + LE+E E+R+ Q +E L R E+ +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEE--ERREQ--QERREQQLRREQEERREQR 518
Query: 1443 LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKN-ELTRRKDSP 1501
L + +E R + S + + + + R KR +EK E RR+
Sbjct: 519 LKRQEEEERLQQRLRS-----------EQQLRREQEERREQLLKREEEKRLEQERREQRL 567
Query: 1502 SRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSV 1561
R ++ Q K EER + R + + + + EE + +
Sbjct: 568 KREQEERRDQLLKREEER-----------------RQQRLKREQEERLEQRLKREEVERL 610
Query: 1562 DKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS 1621
++ ++R + L+ +E +LL E Q E+ Q ++ + Q
Sbjct: 611 EQ---EERREQRLKREEPEEERRQQLL----KSEEQEERRQ-------QQLRREQQERRE 656
Query: 1622 SRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAA 1681
RL + E E + ++ E E ++ +E+E + K K + + D
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 1682 VVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK------KKKEK 1735
R Q S+ + + + Q+ ++++ + +EK
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 1736 KKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1790
+ + + + E +L ++ + +++ + ++KE+ + + ++ K +
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Score = 48.5 bits (114), Expect = 6e-05
Identities = 90/626 (14%), Positives = 236/626 (37%), Gaps = 66/626 (10%)
Query: 1192 DRTPEKDKISLSAPAKKIKLN---RETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVK 1248
DR E+D+ ++++ R K+ ++ +E SEK E + +Q + +
Sbjct: 112 DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDE 171
Query: 1249 GKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAE 1308
R++ E + S G +E+ +R +++ + +
Sbjct: 172 ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ---- 227
Query: 1309 DVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKE-S 1367
Q + ++ D +EE+ K + K +V++ K ++E
Sbjct: 228 ---------QQRRERQDRVFQEEEEKEWR------KRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 1368 EPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTK---DRDYSVLEKENPEKRKNSTQ 1424
E E+++K + Q E + + ++ + K +R E+ ++R+ +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 1425 PEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSS 1484
+E L R E+ + L + +E R + + ++ R+++ RE
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL---RREQQL 389
Query: 1485 SKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHD 1544
+ + + E R++ R + ++ RE++ ++ ++K
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQ---------LRREQEEERHEQKHEQ 440
Query: 1545 HKATYDTKRPNEET----KSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEK 1600
+ KR EE K ++ ++E+ + + ++E + L E + ++
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 1601 EQITGQIDKSTVKPKPQ----------LSHSSRLSSDLTRETDEAAFEPDYNESDS---- 1646
E+ Q+ + + + Q L R L RE +E + E +
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 1647 ---ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1703
E + ++EE + K +++ ++ K + ++ + R +
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEER--LEQRLKREEVERLEQEERREQ 618
Query: 1704 HSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKH 1763
+E Q+ +++++ + +++ ++ ++ K+ ++ E LE+ K
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE----EERLEQRLKR 674
Query: 1764 KHKKKKSKKNKDKEKEKEKDDQKVKS 1789
+H++++ ++ + E+E+E+ +++KS
Sbjct: 675 EHEEER-REQELAEEEQEQARERIKS 699
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 84.3 bits (207), Expect = 9e-16
Identities = 192/940 (20%), Positives = 333/940 (35%), Gaps = 149/940 (15%)
Query: 943 EESEGFLNPELLETSRKSREPTGVEENKTDSLF-VLPSRDDATPVRDEPMDAESITFKSV 1001
E+SE + E S PT V + SL +L ++ ++P + P A + +
Sbjct: 543 EDSES--SSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
Query: 1002 SEKDKRERDKPKAKGDKTKRKNDGSAVS-----------------KKENIVKPAKGPQEK 1044
+EK + + D + +A++ KK N AK +
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 1045 VDGERER------SPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKI-------------T 1085
V + R SP P + P D++ S S ++EK
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 1086 GTPRKAHSKSAKEH--QETKPVKEEKVKKDYS--KDVKSEKLTTKEEKAKKPNEKNKPLD 1141
G KA S K Q T PV K + K K E + EE++ P
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 1142 NKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKIS 1201
K +K + + S+ IS K++ + R P+ +
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
Query: 1202 LSAPAKKIKLNR--------ETGKK--IGSTENISNTKEPSEKLESTSSKVKQEKVKGKV 1251
PA + + +TG + GS+E S+++E +E L K +++ +
Sbjct: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
Query: 1252 R-RKVTGTEGSSSTLVDYTSTSST-------GGSPVRKSEEKTD-----TKRTVIKTMEE 1298
K + +G++ T T S+ GS +S+ + T VIK
Sbjct: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI 960
Query: 1299 YNNDNTAPAEDVIIMIQVP-----------QSKWDKDDFESEEEDV-KSTQPISS----- 1341
+ + N +PA Q +S ESE+EDV +TQ ++
Sbjct: 961 FVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTN 1020
Query: 1342 ----------VGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKS 1391
+ AS+ S+K S+ + +K+ P+ ++ + Q
Sbjct: 1021 VVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQ 1080
Query: 1392 SKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEAR 1451
+K + K K + + E+ + ++S+ S D QG + + +R
Sbjct: 1081 AKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSR 1140
Query: 1452 TSDKHDSTRASSNKD--FTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRN----- 1504
T + T A S++D P++ + Y T + + + K + SPS +
Sbjct: 1141 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK-ATPKLDSSPSVSSTLAA 1199
Query: 1505 KDSASG-QKNKPREERDL--PKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSV 1561
KD G Q+ KP++ + PK G G S ++P + RKP P T ++
Sbjct: 1200 KDDPDGKQEAKPQQAAGMLSPKTG-GKEAASGTTPQKSRKPKKGAGN-----PQASTLAL 1253
Query: 1562 DKN----------PCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKST 1611
N P + + + E + +++ + K + + S
Sbjct: 1254 QSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1313
Query: 1612 VKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVE 1671
+P + S + E EA+ P+ + S+ K +++SG D+K+K
Sbjct: 1314 DQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA--KRDKASG----DVKEK--- 1364
Query: 1672 KAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1731
K K SL G + + G Q+ + SKK+KK
Sbjct: 1365 KGKGSL--------GSQGAKDEPEEELQKGMGTVEGGDQS-----------NPKSKKEKK 1405
Query: 1732 KKEKKKHKKHKKHKKHK-KHAGTEVELEKSQKHKHKKKKS 1770
K +K+K K KK KK K K A T+ SQK K KKKK+
Sbjct: 1406 KSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1445
Score = 61.6 bits (148), Expect = 7e-09
Identities = 124/602 (20%), Positives = 218/602 (36%), Gaps = 102/602 (16%)
Query: 1181 KRKMEPDTE-KMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTS 1239
KRK E D + +T D IS S +++ E + T + + +L ST+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEE------------EEEAEAETAKATPRLASTN 109
Query: 1240 SKVKQEKVKGKVRRKV---TGTEGSSSTLVDYTSTSST------GGSPVRKSEEKTDTKR 1290
S V + ++ K T G + + + +T T G SP + +E +T
Sbjct: 110 SSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANT-- 167
Query: 1291 TVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEED--------VKSTQPISS- 1341
T++ EE + A M+ Q+ +D S ++ VK Q +S
Sbjct: 168 TLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 1342 -----------------VGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD----- 1379
VG +K + P+ K PE+ESE SE+ + ++
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGT 287
Query: 1380 -----VSHEIIQHEVKSSKNSASSEKGKT---KDRDYSVLEKENPEKRKNSTQPEKESNL 1431
S +I+Q S+ + KG T + +V + K + ++ E +
Sbjct: 288 RSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS 347
Query: 1432 DRLNEQGNFKSLSQSSKEARTSDKHDST---RASSNKDFTPNRDKKTDYDTREYSSSKRR 1488
D E K+L Q+ +TS ++ + S K P KT + + KR
Sbjct: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
Query: 1489 DEKNELTRRKDSPSRNKDSASGQKNKPR-EERDLPKKGTGDSKKSNSSPSRDRKPHDHKA 1547
++ + DS A P+ P K +S + ++P+ RK A
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK---ESPRKGAAPAPPRKTGPAAA 464
Query: 1548 TYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQI 1607
+ E+++S + DRE L A N ++ + P+ + G +
Sbjct: 465 QVQVGKQEEDSRSSSEESDSDRE--ALAAMN-----AAQVKPLGKSPQVKPASTMGMGPL 517
Query: 1608 DKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKD 1667
K P + S+ + + E DSES+ EESS + ++
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVGKW-----------EEDSESS----SEESSDSSDGEVPT 562
Query: 1668 KIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSH---SSSASSAESQ 1724
+ ++SL I + + SSP+ P + P Q ++ +S SS ES
Sbjct: 563 AVAPAQEKSLG-------NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESS 615
Query: 1725 DS 1726
DS
Sbjct: 616 DS 617
Score = 53.5 bits (127), Expect = 2e-06
Identities = 64/273 (23%), Positives = 107/273 (39%), Gaps = 34/273 (12%)
Query: 902 LSARDGHNQKDNTKSKEKESENAPGDG-----KGNKHKKHRKRRKGEESEGFLNPELLET 956
L+A+D + K K ++ +P G G +K RK +KG NP+
Sbjct: 1197 LAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAG-----NPQA--- 1248
Query: 957 SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKG 1016
++ N T L P P+ + + A + K ++E ++ER K
Sbjct: 1249 -----STLALQSNITQCLLGQP-----WPLNEAQVQASVV--KVLTELLEQERKKVVDTT 1296
Query: 1017 DKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSS 1076
++ RK S K A+ P+ K + E + K T +S
Sbjct: 1297 KESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTST-------TSK 1349
Query: 1077 SSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEK 1136
K +K +G ++ K + Q K EE+++K ++ K +K KK ++K
Sbjct: 1350 GKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDK 1409
Query: 1137 NKPLDNKGEKRKRKTEEKGVDKDFESSSMKISK 1169
K +K +K K+K +K KD ES S K K
Sbjct: 1410 RK--KDKEKKEKKKKAKKASTKDSESPSQKKKK 1440
Score = 50.1 bits (118), Expect = 2e-05
Identities = 157/868 (18%), Positives = 305/868 (35%), Gaps = 129/868 (14%)
Query: 955 ETSRKSREPTGVEE--NKTDSLFVLPSRDDAT-PVRDEPMDAESITFKSVSEKDKRERD- 1010
++ RKS EP+ ++T+ +P+ A P A+S + + S D+ + +
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEG 214
Query: 1011 KPKAKGDKTKRKNDGSAVSKKENIV-KPAKGPQEKVDGERERSPRSEPPIKKAKEETPKT 1069
KP K + K S+VS KE+ K A P + D + + PP K+AK+ ++
Sbjct: 215 KPSVKPAQVK----ASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEES 270
Query: 1070 DNTKSSSSSQKDEKI-TGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEE 1128
++++ S S+++ T + KA K + + P K K +
Sbjct: 271 ESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 330
Query: 1129 KAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDT 1188
KA KP E ++ + + +T ++S + K SP++ P
Sbjct: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP-- 388
Query: 1189 EKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSE--------KLESTSS 1240
P K + A AK RE + S E+ S + P++ ++ + S+
Sbjct: 389 ----APPGK---TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA 441
Query: 1241 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN 1300
K+ KG T G ++ V R S E++D+ R + M
Sbjct: 442 PAKESPRKGAAPAPPRKT-GPAAAQVQVGKQEEDS----RSSSEESDSDREALAAMN--- 493
Query: 1301 NDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIV 1360
A V + + PQ K ST + +GK A + P+
Sbjct: 494 ------AAQVKPLGKSPQVK------------PASTMGMGPLGKGAGPVPPGKVGPAT-- 533
Query: 1361 KYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK 1420
PS ++ K+ +D S+S E + D + EK
Sbjct: 534 --------PSAQVGKWEED-------------SESSSEESSDSSDGEVPTAVAPAQEKSL 572
Query: 1421 NSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTR 1480
+ K ++ ++ K + D +S+ SS D +
Sbjct: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESS--------DSADSEEAP 624
Query: 1481 EYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDR 1540
++ + ++ + K P + +AS + R P+K + + SSP+
Sbjct: 625 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA--- 681
Query: 1541 KPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEK 1600
T+RP E++ S +++ ++ + + +S G L + +
Sbjct: 682 ------VAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL-------QVKAAS 728
Query: 1601 EQITGQIDKSTV-----KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEE 1655
+ G + + T K P ++ + + ++E + + S ++ SVK+
Sbjct: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
Query: 1656 ESSGNISK----------DLKDKIVEKAKESLDTAAVVQVGISRNQSHSS---------P 1696
++ N + K+V A ++ + RN +S+ P
Sbjct: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
Query: 1697 SVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVE 1756
SV + + + + +QT S SS E DS+++ + + K K H+ A
Sbjct: 849 SVGKAVA-TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK----PSGKTHQIRAALAPA 903
Query: 1757 LEKSQKHKHKKKKSKKNKDKEKEKEKDD 1784
E +K K + ++DD
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDD 931
Score = 48.9 bits (115), Expect = 4e-05
Identities = 53/260 (20%), Positives = 101/260 (38%), Gaps = 24/260 (9%)
Query: 1507 SASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDH----KATYDTKRPNEETKSVD 1562
S G+K K E+ L K T S ++S S + + KAT N D
Sbjct: 57 SELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD 116
Query: 1563 KNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSS 1622
P +EK A+ E +G + +P + ++G+ + + +P
Sbjct: 117 L-PSSMKEK----AKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSA------ 165
Query: 1623 RLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAV 1682
++ L ET+E P + + VS + +SS + D+ + K S+ A V
Sbjct: 166 --NTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223
Query: 1683 VQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHK 1742
+S +S P+R +P+ + + +K+ KK +E+ + +
Sbjct: 224 KASSVSTKES-------PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEG 276
Query: 1743 KHKKHKKHAGTEVELEKSQK 1762
+ + AGT +++ S+K
Sbjct: 277 SESEEEAPAGTRSQVKASEK 296
Score = 43.9 bits (102), Expect = 0.001
Identities = 133/721 (18%), Positives = 258/721 (35%), Gaps = 88/721 (12%)
Query: 1041 PQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQ 1100
P+E + E S SE AK + K+S +PRK + +
Sbjct: 335 PEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKT 394
Query: 1101 ETKPVKEEKVKKDYSKDVKSEKLTTKEE--KAKKPNEKNKPLDNKGEKRKRKTEEKGVDK 1158
K + K++ SE+ ++EE KP+ K + K +
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPA 454
Query: 1159 DFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK 1218
+ ++++V K E D+ + D+ +L+A +N K
Sbjct: 455 PPRKTGPAAAQVQV---------GKQEEDSRSSSEESDSDREALAA------MNAAQVKP 499
Query: 1219 IGSTENISNTKEPSEKLESTSSKVKQEKVKGKV----------RRKVTGTEGSSSTLVDY 1268
+G K P K ST K G V +V E S + +
Sbjct: 500 LG--------KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEE 551
Query: 1269 TSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1328
+S SS G P + + + +++ + P + + +QV K D+ ES
Sbjct: 552 SSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK-PMDNSES 610
Query: 1329 EEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHE 1388
EE S+ S PA++ KP+ +K P+ ++ P + + V+ + +
Sbjct: 611 SEE---SSDSADSEEAPAAMTA-AQAKPA--LKIPQTKACPKKTNTTASAKVAPVRVGTQ 664
Query: 1389 VKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSK 1448
+A+S G + +V +S+ E +S ++ K
Sbjct: 665 APRKAGTATSPAGSSP----AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 1449 EARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRD-----EKNELTRRKDSPSR 1503
+ + S + P KT + + K+ D E+++ SP++
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 1504 NKDSA--SGQKNKPREERDLPKKG---------TGDSKKSNSSPSRDRKP--HDHKATYD 1550
K S + K P R KG T ++ SPS+ + P + +T
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
Query: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
+ P SV K + +E SG+ + E+ E+E T +
Sbjct: 841 ARGP-ASVPSVGKAVATAAQAQT----GPEEDSGS------SEEESDSEEEAET----LA 885
Query: 1611 TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIV 1670
VKP + +H R + +E+ P S +++ SG+ S++
Sbjct: 886 QVKPSGK-THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSD-- 942
Query: 1671 EKAKESLDTAAVVQ---VGISRNQSHSSPSVSPSRSH---SPSGSQTRSHSSSASSAESQ 1724
+A ++ +A V++ + + N+S + P+ +P+++ +P ++ ++ +SS+ES+
Sbjct: 943 GEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESE 1002
Query: 1725 D 1725
D
Sbjct: 1003 D 1003
Score = 40.8 bits (94), Expect = 0.012
Identities = 112/626 (17%), Positives = 215/626 (34%), Gaps = 64/626 (10%)
Query: 955 ETSRKSREPTGVEENKTDSLFVLPS------RDDATPVRDEPMDAESITFKSVSEKDKRE 1008
E S S E + EE V PS R P ++ P + T + +
Sbjct: 866 EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 1009 RDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPK 1068
K G ++ + + K P VD R + + P + TP+
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 1069 ----TDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSK-DVKSEKL 1123
+++T SSSS+ +++ + + + + T P ++ S S K
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKE 1045
Query: 1124 TTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRK 1183
+++ KK +D+ G S + ++ KP
Sbjct: 1046 SSRISDGKKQEGPATQVDSA----------VGTLPATSPQSTSVQAKGTNKLRKPKL--- 1092
Query: 1184 MEPDTEKMDRTPEK--DKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL-ESTSS 1240
P+ ++ + PE D S + + + E + S + T +E L E T++
Sbjct: 1093 --PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAA 1150
Query: 1241 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSST-GGSPVRKSEEKTDTKRTVIKTM--- 1296
+ ++ V S S L Y + T S K+ K D+ +V T+
Sbjct: 1151 ESSEDDVVAP----------SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAK 1200
Query: 1297 EEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKP-ASVIKNVSTK 1355
++ + A + M+ K + S KS +P G P AS + S
Sbjct: 1201 DDPDGKQEAKPQQAAGMLS---PKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNI 1257
Query: 1356 PSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKEN 1415
++ P +E ++Q V E+++ E K ++ K + L +
Sbjct: 1258 TQCLLGQPWPLNEA--QVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQ 1315
Query: 1416 PEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKT 1475
P R ++ +K+ G S S ++ T+ K + R ++ D + K +
Sbjct: 1316 PAARTPRSKKKKKLGA------GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGS 1369
Query: 1476 DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDS---KKS 1532
S +DE E ++ D ++ + K +++ D KK KK+
Sbjct: 1370 ------LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1423
Query: 1533 NSSPSRDRKPHDHKATYDTKRPNEET 1558
+ ++D + K K+ E+T
Sbjct: 1424 KKASTKDSESPSQKKKKKKKKTAEQT 1449
Score = 39.7 bits (91), Expect = 0.027
Identities = 89/383 (23%), Positives = 145/383 (37%), Gaps = 55/383 (14%)
Query: 960 SREPTGVEENKTDSLFV--LPSRDDATPVRDEPMDAE-SITFKSVSEKDKRERDKPKAK- 1015
S + T V+ T+ L LP AT + D+E S S SE+D K+
Sbjct: 1073 SPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAH 1132
Query: 1016 --GDKTKRKN----DGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKT 1069
G R + +A S ++++V P+ Q + G +P P +A + TPK
Sbjct: 1133 TLGPTPSRTETLVEETAAESSEDDVVAPS---QSLLSGYM--TPGLTPANSQASKATPKL 1187
Query: 1070 DNTKSSSSS-----QKDEKITGTPRKAHSK-----SAKEHQE-TKPVKEEKVKKDYSKDV 1118
D++ S SS+ D K P++A KE T P K K KK
Sbjct: 1188 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1247
Query: 1119 KSEKLTTKE------------EKAKKPNEKNKPLDNKGEKRKRK---TEEKGVDKDFESS 1163
S +A+ K L E+ ++K T ++ K +ES
Sbjct: 1248 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESR 1307
Query: 1164 SMKISKLEVTEIVKPSPKRKMEPDTE--KMDRTPEKDKISLSAPAKKIKLNRETGKKIG- 1220
K+S + S K+K E + +PEK + AK+ K + + +K G
Sbjct: 1308 KRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1367
Query: 1221 -STENISNTKEPSEKLES----------TSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYT 1269
S + EP E+L+ ++ K K+EK K R+K + +
Sbjct: 1368 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1427
Query: 1270 STSSTGGSPVRKSEEKTDTKRTV 1292
+ S S +K ++K ++TV
Sbjct: 1428 TKDSESPSQKKKKKKKKTAEQTV 1450
>gi|169218320 PREDICTED: similar to BCL2-associated transcription
factor 1 isoform 2 [Homo sapiens]
Length = 869
Score = 83.2 bits (204), Expect = 2e-15
Identities = 205/984 (20%), Positives = 332/984 (33%), Gaps = 210/984 (21%)
Query: 681 RSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYP---RRG 737
RS SRS S S S SS + S+S S R RS SR++SRS SR S Y R
Sbjct: 3 RSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNN 62
Query: 738 RGKSRNYRSRSRSHG--------YHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQG 789
R R Y R R G YHR R P + R HSRS R +SP +R+V
Sbjct: 63 RAMRRPYGYRGRGRGYYQGGGGRYHRGGYR-PVWNRRHSRSPRRGRSRSRSPKRRSVSSQ 121
Query: 790 ETEREYFNRYREVPPPYDMKAY----YGRS-----------------------VDFRDPF 822
+ YR P + Y +S +
Sbjct: 122 RSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKS 181
Query: 823 EKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPER-FLPLNIRNSPFTRGRRE 881
++E +E E +++ K A P + + SP P I P
Sbjct: 182 QEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCS 241
Query: 882 DY-VGGQSHRSRNIGSNYPEKLS---ARDGHNQKDNTKSKEKESENAP------------ 925
D + H ++N S + + R G N S+ S+N+P
Sbjct: 242 DAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAK 301
Query: 926 ----------------------GDGKGNKHKKHRKRRKGEESEGFL----NPELLETSRK 959
GD + K K KR EES FL N E S++
Sbjct: 302 TIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKE 361
Query: 960 SREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKT 1019
G E + + L D + + D+E E + + + D+
Sbjct: 362 KGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEG---DDTEETEDYRQFRKSVLADQG 418
Query: 1020 KRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKE-----ETPKTDNTKS 1074
K S + +E +K + + G RE E K KE E P T K
Sbjct: 419 KSFATASHRNTEEEGLKYKS--KVSLKGNRESDGFREEKNDKHKETGYVVERPSTTKDKH 476
Query: 1075 SSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKK--DYSKDVKSEKLTTKEEKAKK 1132
+ E+IT KE Q + VK EK+K DYS
Sbjct: 477 KEEDKNSERIT---------VKKETQSPEQVKSEKLKDLFDYS----------------- 510
Query: 1133 PNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEP---DTE 1189
PL + R++ T E S ++I K+ ++ +P K KM P D
Sbjct: 511 -----PPLHKNLDAREKSTFR-------EESPLRI-KMIASDSHRPEVKLKMAPVPLDDS 557
Query: 1190 KMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKG 1249
+ KD++ S +K +E +I + + + +STS Q V
Sbjct: 558 NRPASLTKDRLLASTLVHSVKKEQE-------FRSIFDHIKLPQASKSTSESFIQHIV-- 608
Query: 1250 KVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAED 1309
+LV + + + SE T + K EE++ +P +
Sbjct: 609 --------------SLVHHVKEQYFKSAAMTLSERFTSYQ----KATEEHSTRQKSP--E 648
Query: 1310 VIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEP 1369
+ I + S KD + EE V + E+ +
Sbjct: 649 IHRRIDISPSTLRKDTRLAGEERV----------------------------FKEENQKG 680
Query: 1370 SEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKES 1429
+K++ + D+ H+ I H K KG + R EK + ++ + K+
Sbjct: 681 DKKLRCDSADLRHD-IDHRRKERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSY--KDD 737
Query: 1430 NLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRD 1489
+ + + + S S +S + +S + ++ ++F KT ++ +EYS
Sbjct: 738 SKHKREQDHSLSSSSSASPSSPSSREEKESKKEREEEF------KTHHEMKEYSGFA--- 788
Query: 1490 EKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTG--DSKKSNSSPSRDRKPHDHKA 1547
++R + + ++D K R ++G G + KKS SSP + +
Sbjct: 789 ---GVSRPRGTFHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWNHDKYQGDG 845
Query: 1548 TYDTKRPNEETKSVDKNPCKDREK 1571
+ + E K+ CK+ ++
Sbjct: 846 IVEDEEETMENNEEKKDRCKEEKE 869
Score = 73.6 bits (179), Expect = 2e-12
Identities = 144/748 (19%), Positives = 294/748 (39%), Gaps = 108/748 (14%)
Query: 1051 RSPRSEPPIKKAKEETPK---TDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKE 1107
RSPR +++ +PK + +S S S++ + + +PR + S+S+
Sbjct: 101 RSPRRG----RSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSP--------- 147
Query: 1108 EKVKKDYSKDVKSEKLTTKEEKAKKPN---EKNKPLDNKGEKRKRKTEE----KGVDKDF 1160
YSK S++ ++E++ KK ++ PL +K ++ + T E + +D+
Sbjct: 148 ------YSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFN 201
Query: 1161 ESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIG 1220
+SS+ SP+ P + TP S S +
Sbjct: 202 KSSATSGDIWPGLSAYDNSPR---SPHSPSPIATPPSQSSSCS-----------DAPMLS 247
Query: 1221 STENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVR 1280
+ + NT PS+ S ++ R +G+ G+ S+ + S P R
Sbjct: 248 TVHSAKNT--PSQHSHS---------IQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSR 296
Query: 1281 KSEEKT--------DTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK------WDKDDF 1326
+S KT D R + + TA + +S+ + D
Sbjct: 297 RSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDK 356
Query: 1327 ESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKE---SEPSEKIQKFTKDVSHE 1383
E+ +E + + S K S K+ + E +E +E ++F K V +
Sbjct: 357 EASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLAD 416
Query: 1384 IIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSL 1443
K+ A++ T++ K + + + S +E N D+ E G
Sbjct: 417 -------QGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKN-DKHKETGYVVER 468
Query: 1444 SQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDY--DTREYSSS--KRRDEKNELTRRKD 1499
++K+ + +S R + K+ K++ D +YS K D + + T R++
Sbjct: 469 PSTTKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREE 528
Query: 1500 SPSRNKDSASGQKNK---------PREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYD 1550
SP R K AS P ++ + P T D +++ +K + ++ +D
Sbjct: 529 SPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFD 588
Query: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNN-KESSGNKLLYILNPPETQVEKEQITGQIDK 1609
+ + +KS ++ + H++ ++ KE L+ T +K +
Sbjct: 589 HIKLPQASKSTSESFIQ----HIVSLVHHVKEQYFKSAAMTLSERFTSYQK----ATEEH 640
Query: 1610 STVKPKPQLSHSSRLS-SDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDK 1668
ST + P++ +S S L ++T A E + E + + + ++ + S ++ D+ +
Sbjct: 641 STRQKSPEIHRRIDISPSTLRKDTRLAGEERVFKEENQKGDKKLRCD--SADLRHDIDHR 698
Query: 1669 IVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTR----SHSSSASSAESQ 1724
E++KE D+ + SR Q + +S+ R S SSS+S++ S
Sbjct: 699 RKERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSLSSSSSASPSS 758
Query: 1725 DSKKKKKKKEKKKHKKHKKHKKHKKHAG 1752
S +++K+ +K++ ++ K H + K+++G
Sbjct: 759 PSSREEKESKKEREEEFKTHHEMKEYSG 786
Score = 48.9 bits (115), Expect = 4e-05
Identities = 84/435 (19%), Positives = 171/435 (39%), Gaps = 62/435 (14%)
Query: 1389 VKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSK 1448
V + ++S S +G+++ R +P++R S+Q + + + S S S
Sbjct: 94 VWNRRHSRSPRRGRSRSR--------SPKRRSVSSQRSRSRS-----RRSYRSSRSPRSS 140
Query: 1449 EARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSR----- 1503
+R+S + + S + + KK + + +E S K + ++ + PS
Sbjct: 141 SSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEF 200
Query: 1504 NKDSA---------SGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKP-HDHKATYDTKR 1553
NK SA S N PR T S+ S+ S + H K T
Sbjct: 201 NKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNT----- 255
Query: 1554 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYIL----NPPET----QVEKEQITG 1605
P++ + S+ +P + V + S N ++ + +P +T +++ G
Sbjct: 256 PSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRG 315
Query: 1606 QIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESS-GNISKD 1664
+S+ P +++ L R TDE + + ++ + KE+ S G +
Sbjct: 316 ---RSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSEKGRAEGE 372
Query: 1665 LKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSH-----SPSGSQTRSHSSSAS 1719
+D+ E+LD + + G + + + S Q +S ++++
Sbjct: 373 WEDQ------EALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKSFATASH 426
Query: 1720 SAESQDSKKKKKKKEKKKHK-----KHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNK 1774
++ K K K K ++ + +K+ KHK+ G VE + K KHK++ +
Sbjct: 427 RNTEEEGLKYKSKVSLKGNRESDGFREEKNDKHKE-TGYVVERPSTTKDKHKEEDKNSER 485
Query: 1775 DKEKEKEKDDQKVKS 1789
K++ + ++VKS
Sbjct: 486 ITVKKETQSPEQVKS 500
Score = 45.4 bits (106), Expect = 5e-04
Identities = 66/299 (22%), Positives = 115/299 (38%), Gaps = 27/299 (9%)
Query: 1438 GNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRR 1497
G S S SS+ S +R+ S+ +R K+ +R YS S+ RD R
Sbjct: 2 GRSNSRSHSSRSKSRSQSSSRSRSRSH-----SRKKRYRSRSRTYSRSRSRDRMYSRDYR 56
Query: 1498 KDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1557
+D RN + R + G G + P +R+ ++ + +
Sbjct: 57 RD--YRNNRAMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPK 114
Query: 1558 TKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQ 1617
+SV + R + + + SS ++ + P ++ + G +K T K + +
Sbjct: 115 RRSVSSQRSRSRSRRSYRSSRSPRSSSSR----SSSPYSKSPVSKRRGSQEKQTKKAEGE 170
Query: 1618 LSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESL 1677
S L S ++E + FE D +ES E N K +SG+I L + + S
Sbjct: 171 PQEESPLKSK-SQEEPKDTFEHDPSESIDEFN---KSSATSGDIWPGL--SAYDNSPRSP 224
Query: 1678 DTAAVVQVGISRNQS----------HSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDS 1726
+ + + S++ S HS+ + SHS S RS S S + S+ S
Sbjct: 225 HSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYS 283
Score = 31.6 bits (70), Expect = 7.2
Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 1699 SPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1749
S SRSHS S S++RS SSS S + S KK+ + + + + + + + +
Sbjct: 4 SNSRSHS-SRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSR 53
>gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]
Length = 1226
Score = 82.4 bits (202), Expect = 4e-15
Identities = 157/771 (20%), Positives = 297/771 (38%), Gaps = 119/771 (15%)
Query: 1088 PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKR 1147
P K +K KE + VKE KVK++ ++K K+ +EE+ P E+ KP++++ E++
Sbjct: 409 PEKVVNKQCKECEN---VKEIKVKEENETEIKEIKM--EEERNIIPREE-KPIEDEIERK 462
Query: 1148 KRKTEEKGVDKDF-ESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPA 1206
+ G K+ ES + + I KP ++ + R E I + A
Sbjct: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE 522
Query: 1207 KKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLV 1266
+K K + K ++ P K ++K+K K+ ++ E S
Sbjct: 523 EKAKSGYDEWIKADKIVRPADKNVPKIK--------HRKKIKNKLDKEKDKDEKYSPKNC 574
Query: 1267 DYTSTSS----TGGSPVRKSE-EKTDTKRTVIKTMEEYNNDNTAPAEDVIIM-----IQV 1316
S T SP S+ + TD K N +TA + + I +Q
Sbjct: 575 KLRRLSKPPFQTNPSPEMVSKLDLTDAK-----------NSDTAHIKSIEITSILNGLQA 623
Query: 1317 PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKF 1376
+S + +SE+ED + Q + + GK S I +++ ++++ KE + S + +
Sbjct: 624 SESSAE----DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLI---SKEEQNSSSLLEE 676
Query: 1377 TKDVSHEIIQHEV-KSSKNSASSEKGKTKDRDYSVLE--KENPEKRKNSTQPEKESNLDR 1433
K + +I V KS + + ++D DY E K+ + +K++T + + R
Sbjct: 677 NKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKR 736
Query: 1434 -----LNEQGNFKSLSQSSKEARTSDK-----HDSTRASSNKDFTPNRDKKTDYDTREYS 1483
N + K+ S KE + +K +S+ +SS++D + K T T++Y+
Sbjct: 737 GKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMT--PTKKYN 794
Query: 1484 SSKRRDEK----------NELTRRKDSPSRNKDSASGQKNKPREERDL--------PKKG 1525
+ + + +E+ ++ N D Q ++ ++ +D+ PKK
Sbjct: 795 GLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERL-QNSRAKDRKDVWSSIQGQWPKKT 853
Query: 1526 TGDSKKSNSSPSRDRKPH------------DHKATYDTKRPNEETK-----SVDKNPCKD 1568
+ + + + PH A ++ P+ E + +VD P ++
Sbjct: 854 LKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEE 913
Query: 1569 REKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT---GQIDKSTV------KPKPQLS 1619
+ V + + SSG+ + + PP T +T G +S+V P +
Sbjct: 914 KTVEVNDRKAEFPSSGSNSV-LNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEV 972
Query: 1620 HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDT 1679
S + +D T E D A E +S+ S+ + + S + S + + EKA
Sbjct: 973 RSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKR 1032
Query: 1680 AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK 1739
Q G S ++ + ++ G T S S SA +K + K K
Sbjct: 1033 VKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMK 1092
Query: 1740 KHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1790
H KS K KN DK+ + ++ ++ V
Sbjct: 1093 SHS---------------TKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKV 1128
Score = 72.0 bits (175), Expect = 5e-12
Identities = 155/810 (19%), Positives = 309/810 (38%), Gaps = 103/810 (12%)
Query: 919 KESENAPGDGKGNKHKKHRKRRKGEESEGFLNPEL------LETSRKSREPTGVEENKTD 972
KE EN +++ K K EE + E +E + G ++N +
Sbjct: 418 KECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLE 477
Query: 973 SLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKE 1032
S+ ++ ++ +P D E++ K E K + ++ K K+ K +
Sbjct: 478 SIPTHSDQEKEVNIK-KPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKAD 536
Query: 1033 NIVKPA----------KGPQEKVDGERER----SPR-------SEPPIK--KAKEETPKT 1069
IV+PA K + K+D E+++ SP+ S+PP + + E K
Sbjct: 537 KIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKL 596
Query: 1070 DNTKSSSSSQKDEK-------ITGTPRKAHSKSAKEHQETKPVKE------EKVKKDYSK 1116
D T + +S K + G S E ++ + ++ E+ K D+
Sbjct: 597 DLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLT 656
Query: 1117 DVKSEKLTTKEEKAKKPNEKN---------KPLDNKGEKRKRKTEEKGVDKDFESSSMKI 1167
+ +++ ++ +E+ + E+N KP+ E+ ++ E D D+E +
Sbjct: 657 NNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTK 716
Query: 1168 SKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1227
+ +V K + + +P ++ R + L + K + K+ EN SN
Sbjct: 717 KRKDVK---KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSN 773
Query: 1228 TKEPSEKLESTSSKVKQEKVKG-KVRRKVTGTEG--SSSTLVDYTSTSSTGGSPVRKSEE 1284
+ ++ E+ + +K G + +RK T G S + V S R
Sbjct: 774 SSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNS 833
Query: 1285 KTDTKRTV---------IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKS 1335
+ ++ V KT++E +D+ A P+ ++ ++ E+ +S
Sbjct: 834 RAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAA-ASPPHPAPEEGVAEESLQTVAEE-ES 891
Query: 1336 TQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ--HEVKSSK 1393
P + KP V NV +KP EK E +++ +F S+ ++ S
Sbjct: 892 CSPSVELEKPPPV--NVDSKP-----IEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESP 944
Query: 1394 NSASSEKGKTKDRDYSVLEKENPEKRK-NSTQPEKESNLDRLNEQGNFKSLSQSSKEART 1452
+S + +G + +V E P + + S + E +S ++ + G + L +
Sbjct: 945 SSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPA 1004
Query: 1453 SDKHDSTRASSNKDFTPNRDK-----KTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDS 1507
+ +SSN+ + +K K D + SS ++ +++ K + NK
Sbjct: 1005 GFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS----HKATVVNNKKK 1060
Query: 1508 ASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCK 1567
G + EE + T + S S K H K+ T+ P + K+ DK+P
Sbjct: 1061 GKGTNSSDSEELSAGESIT--KSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDP-- 1116
Query: 1568 DREKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT------GQIDKSTVKPKPQLSHS 1621
L+ +N+ K + ++ E E+IT +I K + K +++
Sbjct: 1117 -----DLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASI 1171
Query: 1622 SRLSSDLTRETDEAAFEPDYNESDSESNVS 1651
R L ++ E+A + S S S+++
Sbjct: 1172 DRRRKRLKKKERESAATSSSSSSPSSSSIT 1201
>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
Length = 1441
Score = 82.0 bits (201), Expect = 5e-15
Identities = 167/898 (18%), Positives = 330/898 (36%), Gaps = 153/898 (17%)
Query: 954 LETSRKSREPTGVEENKTDSLFVLPSRDDATPVRD-EPMDAESITFKSVSEKDKRERDKP 1012
++T +E + ++ S+ VL + + +P + E+ S KD +
Sbjct: 497 MKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTAL 556
Query: 1013 KAKGDKTKRKNDGSAVSKKEN-------IVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1065
+ T + + S +KK+ + K K + +D + +R + K+ E
Sbjct: 557 SSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLE 616
Query: 1066 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTT 1125
+ K + +++ +S I + A K E Q T V + VKK + +K + T
Sbjct: 617 SEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFT 676
Query: 1126 KEEKAKKPNEKN----KPLDNKGEKRKRKTEEKGVDKDFESSS-------------MKIS 1168
K E N + +P + KG +K K + K V ++ ++S +K++
Sbjct: 677 KVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLT 736
Query: 1169 KLEVTEIVKP-SPKRKMEPDT--EKMDRTPEKDKIS--------LSAPAKKI------KL 1211
+ KP SP + +EP+ EK ++ EK + +S P K+ K
Sbjct: 737 IRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKA 796
Query: 1212 NRETGKKIGSTENISNTKEPSEKLE-------STSSKVKQEKVKGKVRRKVTGTEGSSST 1264
+++ G+ E S + ++K E T+SKV + K KGKVR + T G
Sbjct: 797 DKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWK- 855
Query: 1265 LVDYTSTSSTGGSPVRKS------EEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQ 1318
Y+S + GS KS EE+ +++ ++ +E P +I++
Sbjct: 856 ---YSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLC--- 909
Query: 1319 SKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTK 1378
+ S + + P +I P+ E F
Sbjct: 910 ------------DSCDSGYHTACLRPPLMII-------------PDGEW--------FCP 936
Query: 1379 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK-----------NSTQPEK 1427
H+++ +++ + +D D ++ +KE E+RK N P++
Sbjct: 937 PCQHKLLCEKLEE----------QLQDLDVALKKKERAERRKERLVYVGISIENIIPPQE 986
Query: 1428 ESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR 1487
+ E+ S+++ R S + + +F D+ + D +E
Sbjct: 987 PDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGG-- 1044
Query: 1488 RDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKA 1547
R KD ++ ++ ++ + + ++K+ + + RK
Sbjct: 1045 ------------GVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLN 1092
Query: 1548 TYDTKRPNEETKSVDKNPCKD--REKHVLEARNNKESSGNKLLYILNPPETQVEKEQITG 1605
D+ +E +S D+ D +++ V+ N ES + PP
Sbjct: 1093 DLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEED-------PPSND------DS 1139
Query: 1606 QIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDL 1665
D + + + S R S L R+T + + D E +SE N +S + S D
Sbjct: 1140 DTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEEN----SRDSESDFSDDF 1195
Query: 1666 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1725
D VE + Q+ N S S +S R H SS+ES++
Sbjct: 1196 SDDFVETRRRRSRRNQKRQI----NYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEE 1251
Query: 1726 SKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1783
S K ++ + K+ K+ + + + E ++ + + K S+K + + E++
Sbjct: 1252 SYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEE 1309
Score = 79.3 bits (194), Expect = 3e-14
Identities = 155/762 (20%), Positives = 285/762 (37%), Gaps = 118/762 (15%)
Query: 1064 EETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKS--- 1120
+ + + DN+ S S +DE+ T ++ + +E +E++ +K E+ D +
Sbjct: 215 KNSSQQDNSSRESPSLEDEE---TKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVL 271
Query: 1121 EKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSP 1180
E+ T K+EK + P+ K EK + EEK + K+ ES S K E VKP
Sbjct: 272 EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKE-ESDSFK-------ENVKP-- 321
Query: 1181 KRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSS 1240
++ + ++ P+ K S+ P + E G NI ++ E +EK S
Sbjct: 322 ---IKVEVKECRADPKDTKSSMEKPVAQEPERIEFGG------NIKSSHEITEK-----S 367
Query: 1241 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN 1300
+ EK+K + K+ P++K E K +
Sbjct: 368 TEETEKLKNDQQAKI----------------------PLKKREIKL-------------S 392
Query: 1301 NDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS-----------VI 1349
+D +P + + P ++ KD+ + EEE K I+++G V
Sbjct: 393 DDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVA 452
Query: 1350 KNVSTKPSNIVKYPEKESE--PSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKG----KT 1403
N T+P Y KE PS+ T+ E + + S K ++ K
Sbjct: 453 PNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKD 512
Query: 1404 KDRDYSVLEKENPEKR-KNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRAS 1462
D SVLE + + + + PE E++LD + S + S + K +
Sbjct: 513 ADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPK 572
Query: 1463 SNKDFTP---------NRDKKT--DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQ 1511
+ KD P + KKT D D + S K+ L K +++
Sbjct: 573 TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPS 632
Query: 1512 KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREK 1571
E+ +K + + +++ + K K +T + + E V+ + + +
Sbjct: 633 NIIDHCEKLASEKEVVECQSTSTVGGQSVK----KVDLETLKEDSEFTKVEMDNLDNAQT 688
Query: 1572 HVLEARNNKESS--GNKLLYILNPPE--TQVEKEQITGQIDKSTVKPKPQLSHSSRLSSD 1627
+E + + S +K Y L P E T E +IT + K +K ++S +
Sbjct: 689 SGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKP-- 746
Query: 1628 LTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGI 1687
++ EP+ + +E KEEE + N+ + L+ + S TA V ++
Sbjct: 747 ---DSPPKVLEPENKQEKTE-----KEEEKT-NVGRTLR----RSPRISRPTAKVAEIRD 793
Query: 1688 SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK-KKKEKKKHKKHKKHKK 1746
+ S + +T S + +SK K K K K + + +
Sbjct: 794 QKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGR 853
Query: 1747 HKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
K + E E S+K ++ ++ + +E DD+ K
Sbjct: 854 WKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCK 895
Score = 66.6 bits (161), Expect = 2e-10
Identities = 161/838 (19%), Positives = 292/838 (34%), Gaps = 137/838 (16%)
Query: 902 LSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNP---ELLETSR 958
LS+ + K KS + + + P + + + K+ ++ L+P E+ +++
Sbjct: 556 LSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTL 615
Query: 959 KSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDK 1018
+S +P E +T + + E ++ +S + K + + K +
Sbjct: 616 ESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEF 675
Query: 1019 TKRKNDGSAVSKKENIVKPA--KGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSS 1076
TK + D ++ I +P+ KG +K + + P +EET ++NT+ +S
Sbjct: 676 TKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVP---------EEETTASENTEITS 726
Query: 1077 SSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEK 1136
QK+ G S K+ ++ P E K K K E+ T ++
Sbjct: 727 ERQKE----GIKLTIRISSRKKKPDSPPKVLEPENKQ-EKTEKEEEKTNVGRTLRRSPRI 781
Query: 1137 NKPLDNKGEKRKRKTEEK---GVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDR 1193
++P E R +K ++K G D + E S + K + EI+K K E DT
Sbjct: 782 SRPTAKVAEIRDQKADKKRGEGED-EVEEESTALQKTDKKEILK-----KSEKDTNS--- 832
Query: 1194 TPEKDKISLSAPAKKIKLNRETGKKI-GSTENISNTKEPSEKLESTSSKVKQEKVKGKVR 1252
K+S P K+ R TG + G + SN + E +S+ ++E+ K
Sbjct: 833 -----KVSKVKPKGKV---RWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEK---- 880
Query: 1253 RKVTGTEGSSSTLVDYTSTSSTGGSP---------------------------------- 1278
E + L D G P
Sbjct: 881 ------ESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWF 934
Query: 1279 ---------VRKSEEKTDTKRTVIKTME--EYNNDNTAPAEDVIIMIQVPQSKWDKDDFE 1327
K EE+ +K E E + I I PQ +D E
Sbjct: 935 CPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQE 994
Query: 1328 SEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQH 1387
+++D K ++ A++++ ST+ + Y + E E I + +D E
Sbjct: 995 EKKKDSKKSK--------ANLLERRSTRTRKCISY--RFDEFDEAIDEAIEDDIKEADGG 1044
Query: 1388 EVKSSKNSASSEKGKTKDRDYSVLEKENPE-------------KRKNSTQPEKESNLDRL 1434
V K+ ++ + KD ++L++E E KR+ + +SNLD
Sbjct: 1045 GVGRGKDISTITGHRGKDIS-TILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEE 1103
Query: 1435 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL 1494
+ FK S E SD++ S +D N D TD+ +R R +
Sbjct: 1104 ESEDEFKISDGSQDEFVVSDENPD---ESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSR 1160
Query: 1495 TRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRP 1554
R+ +P + ++ RD + D R R + K + K
Sbjct: 1161 RLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKED 1220
Query: 1555 NEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQ------------ 1602
+E S K+ + +E + R S + N + ++ KE
Sbjct: 1221 SESDGS-QKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTD 1279
Query: 1603 --ITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESS 1658
++ + KP R+ +D D A + + DS+ V E+ES+
Sbjct: 1280 EYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQEST 1337
Score = 57.4 bits (137), Expect = 1e-07
Identities = 149/789 (18%), Positives = 290/789 (36%), Gaps = 96/789 (12%)
Query: 910 QKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEEN 969
+ DN + + P + KG+ K K + L PE T+ ++ E T +
Sbjct: 679 EMDNLDNAQTSGIEEPSETKGSMQKSKFKYK--------LVPEEETTASENTEITSERQK 730
Query: 970 KTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDG-SAV 1028
+ L + S P D+ + ++++K E+++ K +T R++ S
Sbjct: 731 EGIKLTIRISSRKKKP------DSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRP 784
Query: 1029 SKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE----TPKTDNTKSSSSSQKDE-K 1083
+ K ++ K +++ +GE E S K K+E + K N+K S K + +
Sbjct: 785 TAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVR 844
Query: 1084 ITGTPRKAHSK-SAKEHQETKPVKEEKVKKDYSKDVKSEK--LTTKEEKAKKPNEKNKPL 1140
TG+ + K S+ + E ++ + ++ +SE+ L +E KK N P
Sbjct: 845 WTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHP- 903
Query: 1141 DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI 1200
E + D S + L ++ P + P K+ ++++
Sbjct: 904 ------------ELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQL 951
Query: 1201 SLSAPAKKIKLNRETGKK----IG-STENISNTKEPSEKLESTSSKVKQEKVKGKV-RRK 1254
A K K E K+ +G S ENI +EP + K +K K + R+
Sbjct: 952 QDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERR 1011
Query: 1255 VTGTEGSSSTLVDYTSTS-----------STGGSPVRKSEEKTDTK---RTVIKTMEEYN 1300
T T S D + + GG R + T T + + ++E
Sbjct: 1012 STRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEER 1071
Query: 1301 NDNTAPAEDVIIMIQVPQSKWDKD-DFESEEEDVKSTQPISSVGKPASVIKNVSTK---- 1355
+N P + + D D D +EE+ + IS + V+ + +
Sbjct: 1072 KENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEE 1131
Query: 1356 --PSN-----------IVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGK 1402
PSN + ++P + S ++++ T + E +S +NS SE
Sbjct: 1132 DPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDF 1191
Query: 1403 TKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRAS 1462
+ D +E R+N +++ N +E + + KE R K + +
Sbjct: 1192 SDDFSDDFVETRRRRSRRNQ---KRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSE 1248
Query: 1463 SNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLP 1522
S + + + + S ++R + D ++ +K R E D
Sbjct: 1249 SEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETD-E 1307
Query: 1523 KKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKES 1582
++ ++ + P+RD +P P+E+ + + E+ E N
Sbjct: 1308 EESCDNAHGDANQPARDSQPR--------VLPSEQESTKKPYRIESDEEEDFE---NVGK 1356
Query: 1583 SGNKLLY-ILNPPETQVEK-----EQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAA 1636
G+ L Y +++ P T + E + G+ + + PK + S+ L+S+ T EA
Sbjct: 1357 VGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAG 1416
Query: 1637 FEPDYNESD 1645
P+ E +
Sbjct: 1417 -APEEEEDE 1424
Score = 48.5 bits (114), Expect = 6e-05
Identities = 84/404 (20%), Positives = 145/404 (35%), Gaps = 50/404 (12%)
Query: 902 LSARDGHNQKD-NTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
+S GH KD +T E+ EN +K R+R +S+ L+ E E K
Sbjct: 1052 ISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKI 1111
Query: 961 REPTGVE-----ENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 1015
+ + E EN +S PS DD+ D S + + R+ + + K
Sbjct: 1112 SDGSQDEFVVSDENPDESEEDPPSNDDSDT------DFCSRRLRRHPSRPMRQSRRLRRK 1165
Query: 1016 GDKTKRKNDGSAVSKKENIVKPAKG-----PQEKVDGERERSPRSEPPIKKAKEETPKTD 1070
K K +D +EN + V+ R RS R++ KE++
Sbjct: 1166 TPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDG 1225
Query: 1071 NTKSSSSSQKDEKI-------TGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKL 1123
+ KS ++ ++ + + SK++++ + K K K+ S D SE
Sbjct: 1226 SQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEAD 1285
Query: 1124 TTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRK 1183
+EE+ KP+ K E+ ++ S ++ E KP +
Sbjct: 1286 EEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKP---YR 1342
Query: 1184 MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVK 1243
+E D E+ + E K+GS + S PS +S +
Sbjct: 1343 IESDEEE---------------------DFENVGKVGSPLDYSLVDLPSTNGQSPGKAI- 1380
Query: 1244 QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1287
E + GK K + +S+ S ++GG EE+ D
Sbjct: 1381 -ENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEED 1423
Score = 37.7 bits (86), Expect = 0.10
Identities = 40/168 (23%), Positives = 59/168 (35%), Gaps = 26/168 (15%)
Query: 637 SREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSP---YSGS 693
S++EF E E+ D+ DF + + R+ R K+P YS
Sbjct: 1115 SQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDD 1174
Query: 694 SYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGY 753
S S+ S S S +S F + R RR + + NY+ S S G
Sbjct: 1175 DEEEESEENSRD-SESDFSDDFSDDFVETRRRR-------SRRNQKRQINYKEDSESDGS 1226
Query: 754 HRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYRE 801
+S R RR H KR + E+E Y ++ E
Sbjct: 1227 QKSLRRGKEIRRVH---------------KRRLSSSESEESYLSKNSE 1259
Score = 37.4 bits (85), Expect = 0.13
Identities = 49/219 (22%), Positives = 86/219 (39%), Gaps = 18/219 (8%)
Query: 1574 LEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD 1633
+E +++++ S K + + N E + QID +K Q +SSR S L E
Sbjct: 177 IEEQDDQDGSSWKCI-VRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEET 235
Query: 1634 EAAFEPDYNESDSESNVSVKEEE----SSGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1689
+ E E ES EE+ + + + L++ V+K KE D +V++
Sbjct: 236 KKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKE--DEKELVKL---- 289
Query: 1690 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1749
P + P + + + S + K + KE + K K K
Sbjct: 290 ------PVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKP 343
Query: 1750 HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
A +E K + ++K+ + E EK K+DQ+ K
Sbjct: 344 VAQEPERIEFGGNIKSSHEITEKSTE-ETEKLKNDQQAK 381
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo
sapiens]
Length = 624
Score = 82.0 bits (201), Expect = 5e-15
Identities = 93/384 (24%), Positives = 154/384 (40%), Gaps = 67/384 (17%)
Query: 1416 PEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKT 1475
PE + E E + R+ E +F S + + +++++ S + + +R
Sbjct: 264 PEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR--SKSRSSSK 321
Query: 1476 DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSS 1535
+ R+ S SK R + +R + R S +++K RE R K + S
Sbjct: 322 SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR----------KSRSRS 371
Query: 1536 PSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPE 1595
SRD++ K T + + E K D+ ++REK E KE NK +
Sbjct: 372 HSRDKR----KDTREKIKEKERVKEKDREKEREREK---EREKEKERGKNK--------D 416
Query: 1596 TQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEE 1655
E+E+ D+ K K D RE ++ + E + E + KE+
Sbjct: 417 RDKEREK-----DREKDKEK-----------DREREREKEHEKDRDKEKEKEQD---KEK 457
Query: 1656 ESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHS 1715
E + SK++ +K + K SR S + SRS S + RS S
Sbjct: 458 EREKDRSKEIDEKRKKDKK-------------SRTPPRSYNASRRSRSSSRERRRRRSRS 504
Query: 1716 SSASSAESQDSKKKKKKKE--KKKHKKHKKHKKHKKHAGTEVELE------KSQKHKHKK 1767
SS S S+ K+K + + ++KK KK +K + H E E KS + K
Sbjct: 505 SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGK 564
Query: 1768 KKSKKNKDKEKEKEKDDQKVKSVT 1791
+K +KN KEKE + + SV+
Sbjct: 565 EKLEKNSTSLKEKEHNKEPDSSVS 588
Score = 81.3 bits (199), Expect = 8e-15
Identities = 94/378 (24%), Positives = 157/378 (41%), Gaps = 34/378 (8%)
Query: 666 AKELMEYKKIQKERRRSFSRSKSPYSGSSYSRS-----SYTYSKSRSG----STRSRSYS 716
AKEL E K +E + S + P SG S R S+T SKSRS S R RS S
Sbjct: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS 331
Query: 717 RSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAF 776
+ SRSH+RS SR R R KS ++ RS+S +SRSRS HSR +
Sbjct: 332 KHRSRSHNRSRSRQKD---RRRSKS-PHKKRSKSRERRKSRSRS------HSRDKRKDT- 380
Query: 777 RGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYRE 836
R + K V + + E+E RE + + G++ D EK+R ++ E+
Sbjct: 381 REKIKEKERVKEKDREKE-----REREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 435
Query: 837 WYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGS 896
EK ++ + + + +R ++ + + R S RSR+ S
Sbjct: 436 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS-SS 494
Query: 897 NYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLET 956
+ +R +K+ +++S +P NK K R++ + SE
Sbjct: 495 RERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSM 554
Query: 957 SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKG 1016
+ S + G E+ + +S + + P +S K V +KD ++ K +
Sbjct: 555 RKSSNDRDGKEKLEKNSTSLKEKEHNKEP--------DSSVSKEVDDKDAPRTEENKIQH 606
Query: 1017 DKTKRKNDGSAVSKKENI 1034
+ + N+ + +K E +
Sbjct: 607 NGNCQLNEENLSTKTEAV 624
Score = 70.5 bits (171), Expect = 1e-11
Identities = 85/446 (19%), Positives = 161/446 (36%), Gaps = 83/446 (18%)
Query: 1351 NVSTKPSNIVKYPEKESEPSEKIQKFTKD----VSHEIIQHEVKSSKNSASSEKGKTKDR 1406
N KP + P+ ++ E++ K ++ +S I KS++ + T+ +
Sbjct: 258 NAIVKPPEMT--PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 315
Query: 1407 DYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKD 1466
S + + KR S + N R ++ +S S K +++ ++ S S ++D
Sbjct: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD 375
Query: 1467 FTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT 1526
+ K T +E K +D + E R K+ R K+ G KNK R+ K+
Sbjct: 376 ----KRKDTREKIKEKERVKEKDREKEREREKE---REKEKERG-KNKDRD-----KERE 422
Query: 1527 GDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNK 1586
D +K + +H+ D ++ E+ K ++ KDR K + E R + S
Sbjct: 423 KDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE--KDRSKEIDEKRKKDKKS--- 477
Query: 1587 LLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDS 1646
+ P+ ++SR S +RE +
Sbjct: 478 --------------------------RTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRT 511
Query: 1647 ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSP 1706
+ K S S++ KDK EK ++ +
Sbjct: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHI----------------------------- 542
Query: 1707 SGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK 1766
S+ R S S +S + + K+K E K+ K K+H K + V E K +
Sbjct: 543 --SERRERERSTSMRKSSNDRDGKEKLE--KNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598
Query: 1767 KKKSKKNKDKEKEKEKDDQKVKSVTV 1792
+++K + + +++ K+ V
Sbjct: 599 TEENKIQHNGNCQLNEENLSTKTEAV 624
Score = 70.1 bits (170), Expect = 2e-11
Identities = 71/337 (21%), Positives = 136/337 (40%), Gaps = 20/337 (5%)
Query: 901 KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
K + R G + +T+SK + S + K ++ KHR R + ++ K
Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-SKHRSRSHNRSRSRQKDRRRSKSPHKK 357
Query: 961 REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK 1020
R + E K+ S SRD R++ + E + K + +RER+K + K +
Sbjct: 358 RSKSR-ERRKSRSRS--HSRDKRKDTREKIKEKERV--KEKDREKEREREKEREKEKERG 412
Query: 1021 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK 1080
+ D +K+ K + + + E E+ E ++ KE+ + D +K +K
Sbjct: 413 KNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 472
Query: 1081 DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL 1140
+K + TP ++++ S + ++ + + + S+ + K ++ P +NK
Sbjct: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK- 531
Query: 1141 DNKGEKRKRKTEEKGVDKDFESSSMKIS-------KLEVTEIVKPSPKRKMEPDTEKMDR 1193
D K EK + E+ +++ +S K S KLE + EPD+
Sbjct: 532 DKKREKERDHISERR-ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 590
Query: 1194 TPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKE 1230
+KD AP + + G + EN+S E
Sbjct: 591 VDDKD-----APRTEENKIQHNGNCQLNEENLSTKTE 622
Score = 64.3 bits (155), Expect = 1e-09
Identities = 79/330 (23%), Positives = 129/330 (39%), Gaps = 47/330 (14%)
Query: 1035 VKPAKGPQEKVDGERERS-----PRSEPPIKKAKEETPKTDNTKS---SSSSQKDEKITG 1086
++P G + G R RS RS ++ + ++S S S QKD + +
Sbjct: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352
Query: 1087 TPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK 1146
+P K SKS + + +KD + +K EK KE+ +K E+ K + + E+
Sbjct: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK-EKERVKEKDREKEREREKEREKEKER 411
Query: 1147 RKRKTEEKGVDKDFESSSMKISKLE-VTEIVKPSPKRK-MEPDTEK---------MDRTP 1195
K K +K +KD E K + E E K K K E D EK +D
Sbjct: 412 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 471
Query: 1196 EKDKISLSAP-----------AKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQ 1244
+KDK S + P + + + R + S K S + S S+ K+
Sbjct: 472 KKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK 531
Query: 1245 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1304
+K + K R + S STS S R +EK + T +K E ++
Sbjct: 532 DKKREKERDHI------SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585
Query: 1305 APAEDVIIMIQVPQSKWDKDDFESEEEDVK 1334
+ +++V DKD +EE ++
Sbjct: 586 SVSKEVD----------DKDAPRTEENKIQ 605
Score = 56.2 bits (134), Expect = 3e-07
Identities = 39/143 (27%), Positives = 67/143 (46%), Gaps = 6/143 (4%)
Query: 1648 SNVSVKEEESSGNISKDLKDKIVEKAKE--SLDTAAVVQVGISRNQSHSSPSVSPSRSHS 1705
+N VK E + + ++++++ +E S +AA+ N+ S S +RS S
Sbjct: 257 NNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKS 316
Query: 1706 PSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKH 1765
S S++ S + S S + + ++K + + HKK K E +S+ H
Sbjct: 317 RSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK--SRERRKSRSRSHSR 374
Query: 1766 KKKKSKKNKDKEKE--KEKDDQK 1786
K+K + K KEKE KEKD +K
Sbjct: 375 DKRKDTREKIKEKERVKEKDREK 397
Score = 54.7 bits (130), Expect = 8e-07
Identities = 45/137 (32%), Positives = 62/137 (45%), Gaps = 15/137 (10%)
Query: 643 REQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTY 702
RE+ R K++EK + + E ++ ++ + K+ KE+ R RSK + S T
Sbjct: 421 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 480
Query: 703 SKSRSGSTRSRSYSRSFSRSHSRSYSRSP-------------PYPRRGRGKSRNYRSRSR 749
+S + S RSRS SR R SRS SRSP P P R R K R + R
Sbjct: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP-RSRNKKDKKREKER 539
Query: 750 SH-GYHRSRSRSPPYRR 765
H R R RS R+
Sbjct: 540 DHISERRERERSTSMRK 556
Score = 50.1 bits (118), Expect = 2e-05
Identities = 56/200 (28%), Positives = 81/200 (40%), Gaps = 22/200 (11%)
Query: 643 REQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTY 702
RE+ R +E+E++K K D KE + ++ KE+ R R K + +
Sbjct: 395 REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE------HEKDRDKE 448
Query: 703 SKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSR--SRS 760
+ + R RS R + P R SR RS SR RSR SRS
Sbjct: 449 KEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRS 508
Query: 761 P----PYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSV 816
P +R SRS SP++ R + KR E ER++ + RE M+ +S
Sbjct: 509 PRTSKTIKRKSSRSPSPRS-RNKKDKKR-----EKERDHISERRERERSTSMR----KSS 558
Query: 817 DFRDPFEKERYREWERKYRE 836
+ RD EK K +E
Sbjct: 559 NDRDGKEKLEKNSTSLKEKE 578
Score = 42.7 bits (99), Expect = 0.003
Identities = 64/331 (19%), Positives = 121/331 (36%), Gaps = 36/331 (10%)
Query: 619 GVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKE 678
G +H+ + + + SR + + + R + + +S+ D + +KK K
Sbjct: 306 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSR----QKDRRRSKSPHKKRSKS 361
Query: 679 RRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGR 738
R R SRS+S +S+ + TR + + + R R R
Sbjct: 362 RERRKSRSRS-------------HSRDKRKDTREKIKEKERVKEKDREKERE----REKE 404
Query: 739 GKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNR 798
+ R +++ R + R + R R + + + K E ERE +R
Sbjct: 405 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK-DR 463
Query: 799 YREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYE-KYYKGYAAGAQPRPSANR 857
+E+ D K R D + Y R E + + ++ PR S
Sbjct: 464 SKEI----DEK----RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTI 515
Query: 858 ENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHN--QKDNTK 915
+ S P + R + D++ + R R+ ++ + + RDG +K++T
Sbjct: 516 KRKSSRSPSPRSRNKKDKKREKERDHISERRERERS--TSMRKSSNDRDGKEKLEKNSTS 573
Query: 916 SKEKESENAPGDGKGNKHKKHRKRRKGEESE 946
KEKE P D +K + + EE++
Sbjct: 574 LKEKEHNKEP-DSSVSKEVDDKDAPRTEENK 603
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [Homo
sapiens]
Length = 508
Score = 82.0 bits (201), Expect = 5e-15
Identities = 93/384 (24%), Positives = 154/384 (40%), Gaps = 67/384 (17%)
Query: 1416 PEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKT 1475
PE + E E + R+ E +F S + + +++++ S + + +R
Sbjct: 148 PEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR--SKSRSSSK 205
Query: 1476 DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSS 1535
+ R+ S SK R + +R + R S +++K RE R K + S
Sbjct: 206 SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR----------KSRSRS 255
Query: 1536 PSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPE 1595
SRD++ K T + + E K D+ ++REK E KE NK +
Sbjct: 256 HSRDKR----KDTREKIKEKERVKEKDREKEREREK---EREKEKERGKNK--------D 300
Query: 1596 TQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEE 1655
E+E+ D+ K K D RE ++ + E + E + KE+
Sbjct: 301 RDKEREK-----DREKDKEK-----------DREREREKEHEKDRDKEKEKEQD---KEK 341
Query: 1656 ESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHS 1715
E + SK++ +K + K SR S + SRS S + RS S
Sbjct: 342 EREKDRSKEIDEKRKKDKK-------------SRTPPRSYNASRRSRSSSRERRRRRSRS 388
Query: 1716 SSASSAESQDSKKKKKKKE--KKKHKKHKKHKKHKKHAGTEVELE------KSQKHKHKK 1767
SS S S+ K+K + + ++KK KK +K + H E E KS + K
Sbjct: 389 SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGK 448
Query: 1768 KKSKKNKDKEKEKEKDDQKVKSVT 1791
+K +KN KEKE + + SV+
Sbjct: 449 EKLEKNSTSLKEKEHNKEPDSSVS 472
Score = 81.3 bits (199), Expect = 8e-15
Identities = 94/378 (24%), Positives = 157/378 (41%), Gaps = 34/378 (8%)
Query: 666 AKELMEYKKIQKERRRSFSRSKSPYSGSSYSRS-----SYTYSKSRSG----STRSRSYS 716
AKEL E K +E + S + P SG S R S+T SKSRS S R RS S
Sbjct: 156 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS 215
Query: 717 RSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAF 776
+ SRSH+RS SR R R KS ++ RS+S +SRSRS HSR +
Sbjct: 216 KHRSRSHNRSRSRQKD---RRRSKS-PHKKRSKSRERRKSRSRS------HSRDKRKDT- 264
Query: 777 RGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYRE 836
R + K V + + E+E RE + + G++ D EK+R ++ E+
Sbjct: 265 REKIKEKERVKEKDREKE-----REREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 319
Query: 837 WYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGS 896
EK ++ + + + +R ++ + + R S RSR+ S
Sbjct: 320 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS-SS 378
Query: 897 NYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLET 956
+ +R +K+ +++S +P NK K R++ + SE
Sbjct: 379 RERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSM 438
Query: 957 SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKG 1016
+ S + G E+ + +S + + P +S K V +KD ++ K +
Sbjct: 439 RKSSNDRDGKEKLEKNSTSLKEKEHNKEP--------DSSVSKEVDDKDAPRTEENKIQH 490
Query: 1017 DKTKRKNDGSAVSKKENI 1034
+ + N+ + +K E +
Sbjct: 491 NGNCQLNEENLSTKTEAV 508
Score = 70.5 bits (171), Expect = 1e-11
Identities = 85/446 (19%), Positives = 161/446 (36%), Gaps = 83/446 (18%)
Query: 1351 NVSTKPSNIVKYPEKESEPSEKIQKFTKD----VSHEIIQHEVKSSKNSASSEKGKTKDR 1406
N KP + P+ ++ E++ K ++ +S I KS++ + T+ +
Sbjct: 142 NAIVKPPEMT--PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 199
Query: 1407 DYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKD 1466
S + + KR S + N R ++ +S S K +++ ++ S S ++D
Sbjct: 200 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD 259
Query: 1467 FTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT 1526
+ K T +E K +D + E R K+ R K+ G KNK R+ K+
Sbjct: 260 ----KRKDTREKIKEKERVKEKDREKEREREKE---REKEKERG-KNKDRD-----KERE 306
Query: 1527 GDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNK 1586
D +K + +H+ D ++ E+ K ++ KDR K + E R + S
Sbjct: 307 KDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE--KDRSKEIDEKRKKDKKS--- 361
Query: 1587 LLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDS 1646
+ P+ ++SR S +RE +
Sbjct: 362 --------------------------RTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRT 395
Query: 1647 ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSP 1706
+ K S S++ KDK EK ++ +
Sbjct: 396 SKTIKRKSSRSPSPRSRNKKDKKREKERDHI----------------------------- 426
Query: 1707 SGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK 1766
S+ R S S +S + + K+K E K+ K K+H K + V E K +
Sbjct: 427 --SERRERERSTSMRKSSNDRDGKEKLE--KNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 482
Query: 1767 KKKSKKNKDKEKEKEKDDQKVKSVTV 1792
+++K + + +++ K+ V
Sbjct: 483 TEENKIQHNGNCQLNEENLSTKTEAV 508
Score = 70.1 bits (170), Expect = 2e-11
Identities = 71/337 (21%), Positives = 136/337 (40%), Gaps = 20/337 (5%)
Query: 901 KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
K + R G + +T+SK + S + K ++ KHR R + ++ K
Sbjct: 183 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-SKHRSRSHNRSRSRQKDRRRSKSPHKK 241
Query: 961 REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK 1020
R + E K+ S SRD R++ + E + K + +RER+K + K +
Sbjct: 242 RSKSR-ERRKSRSRS--HSRDKRKDTREKIKEKERV--KEKDREKEREREKEREKEKERG 296
Query: 1021 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK 1080
+ D +K+ K + + + E E+ E ++ KE+ + D +K +K
Sbjct: 297 KNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 356
Query: 1081 DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL 1140
+K + TP ++++ S + ++ + + + S+ + K ++ P +NK
Sbjct: 357 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK- 415
Query: 1141 DNKGEKRKRKTEEKGVDKDFESSSMKIS-------KLEVTEIVKPSPKRKMEPDTEKMDR 1193
D K EK + E+ +++ +S K S KLE + EPD+
Sbjct: 416 DKKREKERDHISERR-ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 474
Query: 1194 TPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKE 1230
+KD AP + + G + EN+S E
Sbjct: 475 VDDKD-----APRTEENKIQHNGNCQLNEENLSTKTE 506
Score = 64.3 bits (155), Expect = 1e-09
Identities = 79/330 (23%), Positives = 129/330 (39%), Gaps = 47/330 (14%)
Query: 1035 VKPAKGPQEKVDGERERS-----PRSEPPIKKAKEETPKTDNTKS---SSSSQKDEKITG 1086
++P G + G R RS RS ++ + ++S S S QKD + +
Sbjct: 177 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 236
Query: 1087 TPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK 1146
+P K SKS + + +KD + +K EK KE+ +K E+ K + + E+
Sbjct: 237 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK-EKERVKEKDREKEREREKEREKEKER 295
Query: 1147 RKRKTEEKGVDKDFESSSMKISKLE-VTEIVKPSPKRK-MEPDTEK---------MDRTP 1195
K K +K +KD E K + E E K K K E D EK +D
Sbjct: 296 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 355
Query: 1196 EKDKISLSAP-----------AKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQ 1244
+KDK S + P + + + R + S K S + S S+ K+
Sbjct: 356 KKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK 415
Query: 1245 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1304
+K + K R + S STS S R +EK + T +K E ++
Sbjct: 416 DKKREKERDHI------SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 469
Query: 1305 APAEDVIIMIQVPQSKWDKDDFESEEEDVK 1334
+ +++V DKD +EE ++
Sbjct: 470 SVSKEVD----------DKDAPRTEENKIQ 489
Score = 56.2 bits (134), Expect = 3e-07
Identities = 39/143 (27%), Positives = 67/143 (46%), Gaps = 6/143 (4%)
Query: 1648 SNVSVKEEESSGNISKDLKDKIVEKAKE--SLDTAAVVQVGISRNQSHSSPSVSPSRSHS 1705
+N VK E + + ++++++ +E S +AA+ N+ S S +RS S
Sbjct: 141 NNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKS 200
Query: 1706 PSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKH 1765
S S++ S + S S + + ++K + + HKK K E +S+ H
Sbjct: 201 RSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK--SRERRKSRSRSHSR 258
Query: 1766 KKKKSKKNKDKEKE--KEKDDQK 1786
K+K + K KEKE KEKD +K
Sbjct: 259 DKRKDTREKIKEKERVKEKDREK 281
Score = 54.7 bits (130), Expect = 8e-07
Identities = 45/137 (32%), Positives = 62/137 (45%), Gaps = 15/137 (10%)
Query: 643 REQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTY 702
RE+ R K++EK + + E ++ ++ + K+ KE+ R RSK + S T
Sbjct: 305 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 364
Query: 703 SKSRSGSTRSRSYSRSFSRSHSRSYSRSP-------------PYPRRGRGKSRNYRSRSR 749
+S + S RSRS SR R SRS SRSP P P R R K R + R
Sbjct: 365 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP-RSRNKKDKKREKER 423
Query: 750 SH-GYHRSRSRSPPYRR 765
H R R RS R+
Sbjct: 424 DHISERRERERSTSMRK 440
Score = 50.1 bits (118), Expect = 2e-05
Identities = 56/200 (28%), Positives = 81/200 (40%), Gaps = 22/200 (11%)
Query: 643 REQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTY 702
RE+ R +E+E++K K D KE + ++ KE+ R R K + +
Sbjct: 279 REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE------HEKDRDKE 332
Query: 703 SKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSR--SRS 760
+ + R RS R + P R SR RS SR RSR SRS
Sbjct: 333 KEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRS 392
Query: 761 P----PYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSV 816
P +R SRS SP++ R + KR E ER++ + RE M+ +S
Sbjct: 393 PRTSKTIKRKSSRSPSPRS-RNKKDKKR-----EKERDHISERRERERSTSMR----KSS 442
Query: 817 DFRDPFEKERYREWERKYRE 836
+ RD EK K +E
Sbjct: 443 NDRDGKEKLEKNSTSLKEKE 462
Score = 42.7 bits (99), Expect = 0.003
Identities = 64/331 (19%), Positives = 121/331 (36%), Gaps = 36/331 (10%)
Query: 619 GVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKE 678
G +H+ + + + SR + + + R + + +S+ D + +KK K
Sbjct: 190 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSR----QKDRRRSKSPHKKRSKS 245
Query: 679 RRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGR 738
R R SRS+S +S+ + TR + + + R R R
Sbjct: 246 RERRKSRSRS-------------HSRDKRKDTREKIKEKERVKEKDREKERE----REKE 288
Query: 739 GKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNR 798
+ R +++ R + R + R R + + + K E ERE +R
Sbjct: 289 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK-DR 347
Query: 799 YREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYE-KYYKGYAAGAQPRPSANR 857
+E+ D K R D + Y R E + + ++ PR S
Sbjct: 348 SKEI----DEK----RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTI 399
Query: 858 ENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHN--QKDNTK 915
+ S P + R + D++ + R R+ ++ + + RDG +K++T
Sbjct: 400 KRKSSRSPSPRSRNKKDKKREKERDHISERRERERS--TSMRKSSNDRDGKEKLEKNSTS 457
Query: 916 SKEKESENAPGDGKGNKHKKHRKRRKGEESE 946
KEKE P D +K + + EE++
Sbjct: 458 LKEKEHNKEP-DSSVSKEVDDKDAPRTEENK 487
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.124 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,681,304
Number of Sequences: 37866
Number of extensions: 5006245
Number of successful extensions: 84437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1005
Number of HSP's successfully gapped in prelim test: 2311
Number of HSP's that attempted gapping in prelim test: 26554
Number of HSP's gapped (non-prelim): 30897
length of query: 1792
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1675
effective length of database: 13,817,196
effective search space: 23143803300
effective search space used: 23143803300
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.