Guide to the Human Genome
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Search of human proteins with 33469982

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
         (505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                1033   0.0  
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     652   0.0  
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   634   0.0  
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   634   0.0  
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   633   0.0  
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   631   0.0  
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       570   e-162
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      558   e-159
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              557   e-159
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   553   e-157
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   553   e-157
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   545   e-155
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   545   e-155
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   545   e-155
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      490   e-138
gi|4503787 fyn-related kinase [Homo sapiens]                          446   e-125
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   354   1e-97
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             344   9e-95
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               344   9e-95
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             344   9e-95
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             344   9e-95
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             344   9e-95
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   340   2e-93
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   340   2e-93
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]              330   2e-90
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               323   3e-88
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       322   5e-88
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   319   3e-87
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                305   5e-83
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     293   3e-79

>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score = 1033 bits (2670), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK 60
           MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
Sbjct: 1   MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK 60

Query: 61  HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE 120
           HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
Sbjct: 61  HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE 120

Query: 121 MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR 180
           MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
Sbjct: 121 MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR 180

Query: 181 CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS 240
           CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
Sbjct: 181 CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS 240

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360

Query: 361 LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS 420
           LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
Sbjct: 361 LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS 420

Query: 421 FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER 480
           FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
Sbjct: 421 FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER 480

Query: 481 PTFEFLQSVLEDFYTATERQYELQP 505
           PTFEFLQSVLEDFYTATERQYELQP
Sbjct: 481 PTFEFLQSVLEDFYTATERQYELQP 505


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  652 bits (1681), Expect = 0.0
 Identities = 312/463 (67%), Positives = 381/463 (82%), Gaps = 3/463 (0%)

Query: 45  NHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGR 104
           +H +  P       +   VVALYDY A++  DL   KG+++ VL+ +G+WW ARSL T +
Sbjct: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRK 124

Query: 105 EGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSV 164
           EGY+PSN+VARV+SLE E WFF+   RK+AERQLLAP N  GSF+IR+SET KG++SLSV
Sbjct: 125 EGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSV 184

Query: 165 KDVTT-QGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRP 223
           +D    QG+ +KHYKIR LD GG+YISPR TF +LQ LV HY K  DGLCQ+L++PC+  
Sbjct: 185 RDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSS 244

Query: 224 APQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLG 283
            PQ PW +D WEIPR+SL+L +KLG+GQFGEVWM  Y  + KVA+KT+K G+MS EAFL 
Sbjct: 245 KPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLA 304

Query: 284 EANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQ 343
           EANVMK LQH++LV+L+AVVTKEPIYI+TE+MA+G LLDFLK+DEGS+  LP+LID SAQ
Sbjct: 305 EANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 364

Query: 344 IAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWT 402
           IAEGMA+IE+ N IHRDLRAANILVS +L CKIADFGLAR+I D+EYTA+EGAKFPIKWT
Sbjct: 365 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWT 424

Query: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
           APEAI+FG FTIK+DVWSFG+LLME+VTYGR+PYPGMSNPEVIR LERGYRMPRP+ CP 
Sbjct: 425 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPE 484

Query: 463 ELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
           ELY  ++  CW++RPEERPTFE++QSVL+DFYTATE QY+ QP
Sbjct: 485 ELY-NIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  634 bits (1634), Expect = 0.0
 Identities = 305/470 (64%), Positives = 382/470 (81%), Gaps = 11/470 (2%)

Query: 40  PLVVFNHLTPP--PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLA 97
           PLV +    PP  P  ++L      V+AL+ Y   +D DL   KGE+L++L+ +G+WW A
Sbjct: 47  PLVTYEGSNPPASPLQDNL------VIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100

Query: 98  RSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNK 157
           +SL TG+EG++P NFVA+  SLE E WFF++  RK+AERQLLAP N  GSFLIRESE+  
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160

Query: 158 GAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRL 216
           G+FSLSV+D    QGE++KHYKIR LD GG+YISPRITFP L  LV+HY+   DGLC RL
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220

Query: 217 TLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTM 276
           + PC    PQ PW +DEWE+PR++L+LV +LG+GQFGEVWMGYY  + KVA+K+LK+G+M
Sbjct: 221 SRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280

Query: 277 SPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336
           SP+AFL EAN+MK LQH+RLVRLYAVVT+EPIYI+TEYM  G L+DFLKT  G +L++ +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINK 340

Query: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGA 395
           L+DM+AQIAEGMA+IE  N IHRDLRAANILVS+ L CKIADFGLAR+I D+EYTA+EGA
Sbjct: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400

Query: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455
           KFPIKWTAPEAI++G FTIK+DVWSFG+LL E+VT+GR+PYPGM+NPEVI+NLERGYRM 
Sbjct: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460

Query: 456 RPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
           RPD CP ELY+ ++  CW+ RPE+RPTF++L+SVLEDF+TATE QY+ QP
Sbjct: 461 RPDNCPEELYQ-LMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  634 bits (1634), Expect = 0.0
 Identities = 305/470 (64%), Positives = 382/470 (81%), Gaps = 11/470 (2%)

Query: 40  PLVVFNHLTPP--PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLA 97
           PLV +    PP  P  ++L      V+AL+ Y   +D DL   KGE+L++L+ +G+WW A
Sbjct: 47  PLVTYEGSNPPASPLQDNL------VIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100

Query: 98  RSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNK 157
           +SL TG+EG++P NFVA+  SLE E WFF++  RK+AERQLLAP N  GSFLIRESE+  
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160

Query: 158 GAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRL 216
           G+FSLSV+D    QGE++KHYKIR LD GG+YISPRITFP L  LV+HY+   DGLC RL
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220

Query: 217 TLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTM 276
           + PC    PQ PW +DEWE+PR++L+LV +LG+GQFGEVWMGYY  + KVA+K+LK+G+M
Sbjct: 221 SRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280

Query: 277 SPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336
           SP+AFL EAN+MK LQH+RLVRLYAVVT+EPIYI+TEYM  G L+DFLKT  G +L++ +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINK 340

Query: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGA 395
           L+DM+AQIAEGMA+IE  N IHRDLRAANILVS+ L CKIADFGLAR+I D+EYTA+EGA
Sbjct: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400

Query: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455
           KFPIKWTAPEAI++G FTIK+DVWSFG+LL E+VT+GR+PYPGM+NPEVI+NLERGYRM 
Sbjct: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460

Query: 456 RPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
           RPD CP ELY+ ++  CW+ RPE+RPTF++L+SVLEDF+TATE QY+ QP
Sbjct: 461 RPDNCPEELYQ-LMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  633 bits (1632), Expect = 0.0
 Identities = 312/517 (60%), Positives = 396/517 (76%), Gaps = 17/517 (3%)

Query: 1   MGLVSSKKPD---------KEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPP 51
           MG + SK  D         K +P++  ++  +     S + +   P   L+         
Sbjct: 1   MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD 60

Query: 52  PDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSN 111
           P+E  D     VVALY Y  ++  DL   KGEK++VL+  G+WW A+SL+T +EG++PSN
Sbjct: 61  PEEQGD----IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSN 116

Query: 112 FVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQ 170
           +VA++ +LE E WFF+   RK+AERQLLAP N AG+FLIRESET KG+FSLSV+D     
Sbjct: 117 YVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVH 176

Query: 171 GELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA 230
           G++IKHYKIR LD GGYYISPRITFP +  +++HY K+ DGLC+RL   C+ P PQ PW 
Sbjct: 177 GDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD 236

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKA 290
           +D WEIPR+S++LV++LG+GQFGEVWMGYY N+ KVA+KTLK GTMS +AFL EAN+MK 
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKT 296

Query: 291 LQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMA 349
           LQH++LVRLYAVVT+ EPIYI+TEYMA+G LLDFLK+DEG ++ LP+LID SAQIAEGMA
Sbjct: 297 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 356

Query: 350 YIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIH 408
           YIER N IHRDLRAAN+LVSE+L CKIADFGLAR+I D+EYTA+EGAKFPIKWTAPEAI+
Sbjct: 357 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 416

Query: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGV 468
           FG FTIK+DVWSFG+LL E+VTYG++PYPG +N +V+  L +GYRMPR + CP ELY  +
Sbjct: 417 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELY-DI 475

Query: 469 IAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
           +  CW+ + EERPTF++LQSVL+DFYTATE QY+ QP
Sbjct: 476 MKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  631 bits (1627), Expect = 0.0
 Identities = 310/494 (62%), Positives = 386/494 (78%), Gaps = 9/494 (1%)

Query: 15  IKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMND 74
           IK K K   S   V  + +  P    L      T  P     +E    VVALY Y  ++ 
Sbjct: 4   IKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDP-----EEQGDIVVALYPYDGIHP 58

Query: 75  RDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEA 134
            DL   KGEK++VL+  G+WW A+SL+T +EG++PSN+VA++ +LE E WFF+   RK+A
Sbjct: 59  DDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDA 118

Query: 135 ERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRI 193
           ERQLLAP N AG+FLIRESET KG+FSLSV+D     G++IKHYKIR LD GGYYISPRI
Sbjct: 119 ERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRI 178

Query: 194 TFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFG 253
           TFP +  +++HY K+ DGLC+RL   C+ P PQ PW +D WEIPR+S++LV++LG+GQFG
Sbjct: 179 TFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFG 238

Query: 254 EVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTK-EPIYIVT 312
           EVWMGYY N+ KVA+KTLK GTMS +AFL EAN+MK LQH++LVRLYAVVT+ EPIYI+T
Sbjct: 239 EVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIIT 298

Query: 313 EYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEAL 372
           EYMA+G LLDFLK+DEG ++ LP+LID SAQIAEGMAYIER N IHRDLRAAN+LVSE+L
Sbjct: 299 EYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESL 358

Query: 373 CCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTY 431
            CKIADFGLAR+I D+EYTA+EGAKFPIKWTAPEAI+FG FTIK+DVWSFG+LL E+VTY
Sbjct: 359 MCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTY 418

Query: 432 GRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE 491
           G++PYPG +N +V+  L +GYRMPR + CP ELY  ++  CW+ + EERPTF++LQSVL+
Sbjct: 419 GKIPYPGRTNADVMTALSQGYRMPRVENCPDELY-DIMKMCWKEKAEERPTFDYLQSVLD 477

Query: 492 DFYTATERQYELQP 505
           DFYTATE QY+ QP
Sbjct: 478 DFYTATEGQYQQQP 491


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  570 bits (1469), Expect = e-162
 Identities = 283/446 (63%), Positives = 349/446 (78%), Gaps = 8/446 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           VALYDY A  + DL   KGEK Q+L  + GDWW ARSL TG  GY+PSN+VA V+S++ E
Sbjct: 88  VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
            W+F   GRK+AERQLL+  N  G+FLIRESET KGA+SLS++D    +G+ +KHYKIR 
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQ----NPWAQDEWEIP 237
           LD GGYYI+ R  F +LQ LVQHYS++  GLC RL +PC +  P+    +   +D WEIP
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIP 267

Query: 238 RQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLV 297
           R+SL+L+++LG+GQFGEVWMG +  N KVAIKTLK GTMSPE+FL EA +MK L+H++LV
Sbjct: 268 RESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLV 327

Query: 298 RLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSI 357
           +LYAVV++EPIYIVTEYM +G LLDFLK  EG  L LP L+DM+AQ+A GMAYIERMN I
Sbjct: 328 QLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387

Query: 358 HRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKA 416
           HRDLR+ANILV   L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA  +G FTIK+
Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447

Query: 417 DVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSR 476
           DVWSFG+LL E+VT GRVPYPGM+N EV+  +ERGYRMP P  CP  L+  ++  CW+  
Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKD 506

Query: 477 PEERPTFEFLQSVLEDFYTATERQYE 502
           PEERPTFE+LQS LED++TATE QY+
Sbjct: 507 PEERPTFEYLQSFLEDYFTATEPQYQ 532


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  558 bits (1438), Expect = e-159
 Identities = 281/443 (63%), Positives = 341/443 (76%), Gaps = 5/443 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           VALYDY A  + DL   KGEK Q+L  + GDWW ARSL TG  GY+PSN+VA V+S++ E
Sbjct: 88  VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
            W+F   GRK+AERQLL+  N  G+FLIRESET KGA+SLS++D    +G+ +KHYKIR 
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
           LD GGYYI+ R  F +LQ LVQHYS+K DGLC  LT+      PQ    A+D WE+ R+S
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRS 267

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           L L +KLG G F EVW+G +  N KVAIKTLK GTMSPE+FL EA +MK L+H++LV+LY
Sbjct: 268 LCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 327

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVV++EPIYIVTEYM +G LLDFLK  EG  L LP L+DM+AQ+A GMAYIERMN IHRD
Sbjct: 328 AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRD 387

Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
           LR+ANILV   L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA  +G FTIK+DVW
Sbjct: 388 LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 447

Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
           SFG+LL E+VT GRVPYPGM+N EV+  +ERGYRMP P  CP  L+  ++  CW+  PEE
Sbjct: 448 SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEE 506

Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
           RPTFE+LQS LED++TATE QY+
Sbjct: 507 RPTFEYLQSFLEDYFTATEPQYQ 529


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  557 bits (1436), Expect = e-159
 Identities = 277/443 (62%), Positives = 340/443 (76%), Gaps = 5/443 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           VALYDY A    DL   KGE+ Q++  T GDWW ARS+ TG+ GY+PSN+VA  +S++ E
Sbjct: 97  VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAE 156

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
            W+F   GRK+AER LL P N+ G FL+RESET KGA+SLS++D    +G+ +KHYKIR 
Sbjct: 157 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRK 216

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
           LD GGYYI+ R  F +LQ LV+HY++  DGLC +LT  C    PQ    A+D WEIPR+S
Sbjct: 217 LDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRES 276

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           LRL  KLG G FGEVWMG +    KVAIKTLK GTM PEAFL EA +MK L+H++LV LY
Sbjct: 277 LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY 336

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVV++EPIYIVTE+M++G LLDFLK  +G  L LP+L+DM+AQIA+GMAYIERMN IHRD
Sbjct: 337 AVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRD 396

Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
           LRAANILV E L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA  +G FTIK+DVW
Sbjct: 397 LRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 456

Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
           SFG+L  E+VT GRVPYPGM N EV+  +ERGYRMP P  CP  L+  ++  CW+  P+E
Sbjct: 457 SFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE-LMNLCWKKDPDE 515

Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
           RPTFE++QS LED++TATE QY+
Sbjct: 516 RPTFEYIQSFLEDYFTATEPQYQ 538


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  553 bits (1426), Expect = e-157
 Identities = 278/443 (62%), Positives = 338/443 (76%), Gaps = 5/443 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           VALYDY +  + DL   KGE+LQ++  T GDWWLA SL TG+ GY+PSN+VA  +S++ E
Sbjct: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDV-TTQGELIKHYKIRC 181
            W+F    R+E+ER LL   N  G+FL+RESET KGA+ LSV D    +G  +KHYKIR 
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
           LD GG+YI+ R  F SLQ LV +YSK  DGLC RLT  C    PQ    A+D WEIPR+S
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           LRL  KLG G FGEVWMG +    +VAIKTLK GTMSPEAFL EA VMK L+HE+LV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVV++EPIYIVTEYM++G LLDFLK + G  L LP+L+DM+AQIA GMAY+ERMN +HRD
Sbjct: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389

Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
           LRAANILV E L CK+ADFGLAR+I D+EYTA++GAKFPIKWTAPEA  +G FTIK+DVW
Sbjct: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449

Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
           SFG+LL E+ T GRVPYPGM N EV+  +ERGYRMP P  CP  L+  ++ +CWR  PEE
Sbjct: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH-DLMCQCWRKEPEE 508

Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
           RPTFE+LQ+ LED++T+TE QY+
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  553 bits (1426), Expect = e-157
 Identities = 278/443 (62%), Positives = 338/443 (76%), Gaps = 5/443 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           VALYDY +  + DL   KGE+LQ++  T GDWWLA SL TG+ GY+PSN+VA  +S++ E
Sbjct: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDV-TTQGELIKHYKIRC 181
            W+F    R+E+ER LL   N  G+FL+RESET KGA+ LSV D    +G  +KHYKIR 
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
           LD GG+YI+ R  F SLQ LV +YSK  DGLC RLT  C    PQ    A+D WEIPR+S
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           LRL  KLG G FGEVWMG +    +VAIKTLK GTMSPEAFL EA VMK L+HE+LV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVV++EPIYIVTEYM++G LLDFLK + G  L LP+L+DM+AQIA GMAY+ERMN +HRD
Sbjct: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389

Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
           LRAANILV E L CK+ADFGLAR+I D+EYTA++GAKFPIKWTAPEA  +G FTIK+DVW
Sbjct: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449

Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
           SFG+LL E+ T GRVPYPGM N EV+  +ERGYRMP P  CP  L+  ++ +CWR  PEE
Sbjct: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH-DLMCQCWRKEPEE 508

Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
           RPTFE+LQ+ LED++T+TE QY+
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  545 bits (1403), Expect = e-155
 Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           +ALYDY A  + DL   KGEK  +L  T GDWW ARSL +G+ G +PSN+VA V+S++ E
Sbjct: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181
            W+F   GRK+AERQLL+P N  G+FLIRESET KGA+SLS++D   T+G+ +KHYKIR 
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240
           LD GGYYI+ R+ F S+Q LVQHY +  DGLC  L  PC    PQ    A+D WEI R S
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           + L R+LG+G FG+VW+G +  + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY
Sbjct: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVV++EPIYIVTE+M  G LLDFLK  EG  L LP+L+DM+AQ+AEGMAY+ERMN IHRD
Sbjct: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382

Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
           LRAANILV E L CKIADFGLAR+I D EY   +G+KFPIKWTAPEA  FG FTIK+DVW
Sbjct: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442

Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
           SFG+LL E++T GR+PYPGM+  EV+  +E+GY MP P  CP  LY   + + WR  PEE
Sbjct: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501

Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
           RPTFE+LQS LED++T+ E QY+
Sbjct: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  545 bits (1403), Expect = e-155
 Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           +ALYDY A  + DL   KGEK  +L  T GDWW ARSL +G+ G +PSN+VA V+S++ E
Sbjct: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181
            W+F   GRK+AERQLL+P N  G+FLIRESET KGA+SLS++D   T+G+ +KHYKIR 
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240
           LD GGYYI+ R+ F S+Q LVQHY +  DGLC  L  PC    PQ    A+D WEI R S
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           + L R+LG+G FG+VW+G +  + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY
Sbjct: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVV++EPIYIVTE+M  G LLDFLK  EG  L LP+L+DM+AQ+AEGMAY+ERMN IHRD
Sbjct: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382

Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
           LRAANILV E L CKIADFGLAR+I D EY   +G+KFPIKWTAPEA  FG FTIK+DVW
Sbjct: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442

Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
           SFG+LL E++T GR+PYPGM+  EV+  +E+GY MP P  CP  LY   + + WR  PEE
Sbjct: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501

Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
           RPTFE+LQS LED++T+ E QY+
Sbjct: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  545 bits (1403), Expect = e-155
 Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           +ALYDY A  + DL   KGEK  +L  T GDWW ARSL +G+ G +PSN+VA V+S++ E
Sbjct: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181
            W+F   GRK+AERQLL+P N  G+FLIRESET KGA+SLS++D   T+G+ +KHYKIR 
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240
           LD GGYYI+ R+ F S+Q LVQHY +  DGLC  L  PC    PQ    A+D WEI R S
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262

Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
           + L R+LG+G FG+VW+G +  + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY
Sbjct: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322

Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
           AVV++EPIYIVTE+M  G LLDFLK  EG  L LP+L+DM+AQ+AEGMAY+ERMN IHRD
Sbjct: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382

Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
           LRAANILV E L CKIADFGLAR+I D EY   +G+KFPIKWTAPEA  FG FTIK+DVW
Sbjct: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442

Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
           SFG+LL E++T GR+PYPGM+  EV+  +E+GY MP P  CP  LY   + + WR  PEE
Sbjct: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501

Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
           RPTFE+LQS LED++T+ E QY+
Sbjct: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  490 bits (1261), Expect = e-138
 Identities = 256/442 (57%), Positives = 309/442 (69%), Gaps = 55/442 (12%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
           VALYDY A  + DL   KGEK Q+L  + GDWW ARSL TG  GY+PSN+VA V+S++ E
Sbjct: 88  VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147

Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
            W+F   GRK+AERQLL+  N  G+FLIRESET KGA+SLS++D    +G+ +KHYKIR 
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207

Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSL 241
           LD GGYYI+ R  F +LQ LVQHYS                                   
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYS----------------------------------- 232

Query: 242 RLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYA 301
                           G +  N KVAIKTLK GTMSPE+FL EA +MK L+H++LV+LYA
Sbjct: 233 ----------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYA 276

Query: 302 VVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDL 361
           VV++EPIYIVTEYM +G LLDFLK  EG  L LP L+DM+AQ+A GMAYIERMN IHRDL
Sbjct: 277 VVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL 336

Query: 362 RAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS 420
           R+ANILV   L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA  +G FTIK+DVWS
Sbjct: 337 RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 396

Query: 421 FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER 480
           FG+LL E+VT GRVPYPGM+N EV+  +ERGYRMP P  CP  L+  ++  CW+  PEER
Sbjct: 397 FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEER 455

Query: 481 PTFEFLQSVLEDFYTATERQYE 502
           PTFE+LQS LED++TATE QY+
Sbjct: 456 PTFEYLQSFLEDYFTATEPQYQ 477


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  446 bits (1147), Expect = e-125
 Identities = 229/452 (50%), Positives = 310/452 (68%), Gaps = 23/452 (5%)

Query: 61  HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGD-WWLARSLVTGREG-------YVPSNF 112
           H+ VAL+DY A    DL    G+KLQVL    + WW AR L   R+G       Y+PSN+
Sbjct: 45  HYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNY 104

Query: 113 VARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGE 172
           VA   SL+ E WFF + GR +AE+QLL   NK GSFLIRESE+ KG FSLSV D    G 
Sbjct: 105 VAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD----GA 160

Query: 173 LIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVR---PAPQNPW 229
           ++KHY+I+ LDEGG++++ R  F +L   V HY+K  DGLC +L  PC++   PAP +  
Sbjct: 161 VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLS 220

Query: 230 AQ--DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANV 287
            +  D+WEI R S++L+++LGSGQFGEVW G + N   VA+KTLK G+M P  FL EA +
Sbjct: 221 YKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQI 280

Query: 288 MKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAE 346
           MK L+H +L++LYAV T E PIYI+TE M  G L ++L+ D GS++ L + +DM+AQ+A 
Sbjct: 281 MKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVAS 340

Query: 347 GMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARI--IDSE--YTAQEGAKFPIKWT 402
           GMAY+E  N IHRDL A N+LV E    K+ADFGLAR+  +D+E  Y ++   K P+KWT
Sbjct: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400

Query: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
           APEAI    F+IK+DVWSFG+LL E++TYG++PY GM+  +VI+ L + YR+P+P  CP 
Sbjct: 401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQ 460

Query: 463 ELYRGVIAECWRSRPEERPTFEFLQSVLEDFY 494
           + Y  ++ ECW + P+ERPTFE L+  LED++
Sbjct: 461 QFY-NIMLECWNAEPKERPTFETLRWKLEDYF 491


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  354 bits (908), Expect = 1e-97
 Identities = 195/448 (43%), Positives = 270/448 (60%), Gaps = 15/448 (3%)

Query: 49  PPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGRE--G 106
           P  P E         +ALYD+TA    +L + +G++L  L+  G +  AR L +G+   G
Sbjct: 42  PTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRL-SGQPSAG 100

Query: 107 YVPSNFVARV--ESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSV 164
            VP   VA+   E+L  + W+F    R +A++ LL+P N+ G+FLIR SE++ G +SLSV
Sbjct: 101 LVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSV 160

Query: 165 KDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPA 224
           +        + HY++    +G  Y+     FP L+ L+ +Y      +   L  PC+   
Sbjct: 161 RAQAK----VCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM--- 213

Query: 225 PQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGE 284
           PQ    QD WE P     L RKLG G FGEVW G +  ++ VAIK +K   M       E
Sbjct: 214 PQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKE 273

Query: 285 ANVMKALQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQ 343
              +K L+HERL+RL+AV +  EP+YIVTE M +G L  FL T EG  L LP L+  + Q
Sbjct: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333

Query: 344 IAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWT 402
           +AEGM+Y+E    +HRDL A N+LV + L CK+ADFGLAR++ D  Y+    +K P+KWT
Sbjct: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWT 393

Query: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
           APEA ++ VF+ K+DVWSFGVLL EV TYG+ PY GM+N E ++ + RGYR+PRP  CP 
Sbjct: 394 APEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPA 453

Query: 463 ELYRGVIAECWRSRPEERPTFEFLQSVL 490
           E+Y  ++ ECWRS PEERP+F  L+  L
Sbjct: 454 EVY-VLMLECWRSSPEERPSFATLREKL 480


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  344 bits (883), Expect = 9e-95
 Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)

Query: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W   RS     +G+VPSN++ 
Sbjct: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148

Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 202

Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
            HY+I    +G  Y++    F +L  LV H+S   DGL   L  P   C +P        
Sbjct: 203 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 262

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
            D+WE+ R  + +  KLG GQ+GEV++G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 263 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 322

Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
            ++H  LV+L  V T EP  YIVTEYM  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382

Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 442

Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+GYRM +P+ CPP++Y  
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 501

Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
           ++  CW+  P +RP+F       E  +
Sbjct: 502 LMRACWKWSPADRPSFAETHQAFETMF 528


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  344 bits (883), Expect = 9e-95
 Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)

Query: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W   RS     +G+VPSN++ 
Sbjct: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 163

Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 217

Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
            HY+I    +G  Y++    F +L  LV H+S   DGL   L  P   C +P        
Sbjct: 218 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 277

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
            D+WE+ R  + +  KLG GQ+GEV++G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 278 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 337

Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
            ++H  LV+L  V T EP  YIVTEYM  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 397

Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 457

Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+GYRM +P+ CPP++Y  
Sbjct: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 516

Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
           ++  CW+  P +RP+F       E  +
Sbjct: 517 LMRACWKWSPADRPSFAETHQAFETMF 543


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  344 bits (883), Expect = 9e-95
 Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)

Query: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W   RS     +G+VPSN++ 
Sbjct: 85  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 142

Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 143 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 196

Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
            HY+I    +G  Y++    F +L  LV H+S   DGL   L  P   C +P        
Sbjct: 197 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 256

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
            D+WE+ R  + +  KLG GQ+GEV++G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 257 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 316

Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
            ++H  LV+L  V T EP  YIVTEYM  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 317 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 376

Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 377 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 436

Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+GYRM +P+ CPP++Y  
Sbjct: 437 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 495

Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
           ++  CW+  P +RP+F       E  +
Sbjct: 496 LMRACWKWSPADRPSFAETHQAFETMF 522


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  344 bits (883), Expect = 9e-95
 Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)

Query: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W   RS     +G+VPSN++ 
Sbjct: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148

Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 202

Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
            HY+I    +G  Y++    F +L  LV H+S   DGL   L  P   C +P        
Sbjct: 203 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 262

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
            D+WE+ R  + +  KLG GQ+GEV++G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 263 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 322

Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
            ++H  LV+L  V T EP  YIVTEYM  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382

Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 442

Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+GYRM +P+ CPP++Y  
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 501

Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
           ++  CW+  P +RP+F       E  +
Sbjct: 502 LMRACWKWSPADRPSFAETHQAFETMF 528


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  344 bits (883), Expect = 9e-95
 Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)

Query: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W   RS     +G+VPSN++ 
Sbjct: 70  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 127

Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 128 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 181

Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
            HY+I    +G  Y++    F +L  LV H+S   DGL   L  P   C +P        
Sbjct: 182 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 241

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
            D+WE+ R  + +  KLG GQ+GEV++G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 242 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 301

Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
            ++H  LV+L  V T EP  YIVTEYM  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 302 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 361

Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 362 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 421

Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+GYRM +P+ CPP++Y  
Sbjct: 422 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 480

Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
           ++  CW+  P +RP+F       E  +
Sbjct: 481 LMRACWKWSPADRPSFAETHQAFETMF 507


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  340 bits (872), Expect = 2e-93
 Identities = 191/457 (41%), Positives = 273/457 (59%), Gaps = 18/457 (3%)

Query: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W  A++     +G+VPSN++ 
Sbjct: 60  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 117

Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 118 PVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---YEGR-V 171

Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA---- 230
            HY+I    +G  Y+S    F +L  LV H+S   DGL   L  P  +      +     
Sbjct: 172 YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 231

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
            D+WE+ R  + +  KLG GQ+GEV+ G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 232 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 291

Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
            ++H  LV+L  V T+EP  YI+TE+M  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 351

Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 352 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 411

Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+ YRM RP+ CP ++Y  
Sbjct: 412 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE- 470

Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQ 504
           ++  CW+  P +RP+F  +    E  +  +    E++
Sbjct: 471 LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 507


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  340 bits (872), Expect = 2e-93
 Identities = 191/457 (41%), Positives = 273/457 (59%), Gaps = 18/457 (3%)

Query: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W  A++     +G+VPSN++ 
Sbjct: 79  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 136

Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 137 PVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---YEGR-V 190

Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA---- 230
            HY+I    +G  Y+S    F +L  LV H+S   DGL   L  P  +      +     
Sbjct: 191 YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 250

Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
            D+WE+ R  + +  KLG GQ+GEV+ G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 251 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 310

Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
            ++H  LV+L  V T+EP  YI+TE+M  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 311 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 370

Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 371 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 430

Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+ YRM RP+ CP ++Y  
Sbjct: 431 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE- 489

Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQ 504
           ++  CW+  P +RP+F  +    E  +  +    E++
Sbjct: 490 LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 526


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score =  330 bits (846), Expect = 2e-90
 Identities = 179/436 (41%), Positives = 256/436 (58%), Gaps = 11/436 (2%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTG----REGYVPSNFVARVESL 119
           V L+D+ +  D +L    G+   V +    WW A  L        +GYVP N++A  E++
Sbjct: 14  VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73

Query: 120 EMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKI 179
           E E WFF    R EA R+L A  N  G+FLIR SE     + LSV+D     + ++HYKI
Sbjct: 74  ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT----QAVRHYKI 129

Query: 180 RCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQ 239
                G  +++  ++F SL  LV ++  +      RL  PC +  P+     D+WE PR+
Sbjct: 130 WRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPRE 189

Query: 240 SLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFL-GEANVMKALQHERLVR 298
              L RKLGSG FGEV+ G +K+ ++VAIK +    +  +  L  E   MK L+H+ ++ 
Sbjct: 190 EFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILA 249

Query: 299 LYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSI 357
           LYAVV+  +P+YI+TE MA+G LL+ L+  +   L +  L+D++ Q+AEGM Y+E  N I
Sbjct: 250 LYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYI 309

Query: 358 HRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKAD 417
           HRDL A NILV E   CK+ DFGLAR+I  +         P KWTAPEA+  G ++ K+D
Sbjct: 310 HRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSD 369

Query: 418 VWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRP 477
           VWSFG+LL E+ + G+VPYPGMSN E    ++ GYRMP P  CPP +++ ++  CW   P
Sbjct: 370 VWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK-LMLTCWCRDP 428

Query: 478 EERPTFEFLQSVLEDF 493
           E+RP F+ L+  L  F
Sbjct: 429 EQRPCFKALRERLSSF 444


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  323 bits (827), Expect = 3e-88
 Identities = 188/476 (39%), Positives = 277/476 (58%), Gaps = 20/476 (4%)

Query: 38  LPPLVVFNHLTPPPPD--EHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDW 94
           LPP        PPPP   E  D  +  VVA+YD+ A    DL++ +G++  +L K    W
Sbjct: 157 LPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHW 216

Query: 95  WLARSLVTGREGYVPSNFVARVES--LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRE 152
           W AR    G EGY+PSN+V   +S  L+   W+ R+  R +AE QLL   +K G F++R+
Sbjct: 217 WRARDKY-GNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRD 274

Query: 153 SETNKGAFSLSV--KDVTTQGELIKHYKIR--CLDEGGYYISPRITFPSLQALVQHYSKK 208
           S +  G +++S+  K         +HY I+        YY++ +  F S+  +++++   
Sbjct: 275 S-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHN 333

Query: 209 GDGLCQRLTLPCVRPAPQNP----WAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNM 264
             GL  RL  P        P    ++ ++WEI    L  +R+LGSG FG V +G ++   
Sbjct: 334 AAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQY 393

Query: 265 KVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDF 323
           KVAIK ++EG M  E F+ EA VM  L H +LV+LY V T++ PIYIVTE+M RGCLL+F
Sbjct: 394 KVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNF 453

Query: 324 LKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR 383
           L+  +G   S   L+ M   + EGM Y+ER + IHRDL A N LVSEA   K++DFG+AR
Sbjct: 454 LRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMAR 512

Query: 384 -IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNP 442
            ++D +YT+  GAKFP+KW  PE  ++  F+ K+DVWSFGVL+ EV T GR+P+   +N 
Sbjct: 513 YVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNY 572

Query: 443 EVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATE 498
           EV+  + RG+R+ +P      +Y  V+  CW+ +PE RP+FE L   +++     E
Sbjct: 573 EVVTMVTRGHRLYQPKLASNYVYE-VMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  322 bits (825), Expect = 5e-88
 Identities = 183/457 (40%), Positives = 279/457 (61%), Gaps = 21/457 (4%)

Query: 49  PPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDWWLARSLVTGREGY 107
           PP P   + E+K  V ALYD+      +L + + E+  +L K    WW AR  + G EG 
Sbjct: 73  PPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRL-GNEGL 131

Query: 108 VPSNFVA--RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVK 165
           +PSN+V   ++ +LE+  W+ R+  R +AE  LL   +K G+F++R+S  + G++++SV 
Sbjct: 132 IPSNYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSR-HLGSYTISVF 189

Query: 166 DVTTQGE--LIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---- 219
               +     IKHY+I+  D G +Y++ R  F S+  L+ ++     GL  RL  P    
Sbjct: 190 MGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLM 249

Query: 220 --CVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMS 277
             C+ PA    ++ ++WEI    L  ++++GSGQFG V +G ++++++VAIK + EG+MS
Sbjct: 250 GSCL-PATAG-FSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMS 307

Query: 278 PEAFLGEANVMKALQHERLVRLYAV-VTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336
            E F+ EA VM  L H +LV+LY V + ++P+YIVTE+M  GCLL++L+ ++G +L    
Sbjct: 308 EEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEM 366

Query: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR-IIDSEYTAQEGA 395
           L+ +   I EGM Y+ER   IHRDL A N LVS     KI+DFG+ R ++D EY +  GA
Sbjct: 367 LLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGA 426

Query: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455
           KFPIKW+ PE   F  ++ K+DVWSFGVL+ EV T G++P+   SN +V+  +  G+R+ 
Sbjct: 427 KFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLY 486

Query: 456 RPDTCPPELYRGVIAECWRSRPEERPTF-EFLQSVLE 491
           RP   P  +Y  V+  CW  +PE RPTF E L++V E
Sbjct: 487 RPHLAPMSIYE-VMYSCWHEKPEGRPTFAELLRAVTE 522


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  319 bits (818), Expect = 3e-87
 Identities = 181/481 (37%), Positives = 282/481 (58%), Gaps = 23/481 (4%)

Query: 29  SAQDKDAPPLPPLVVFNHLT--PPPPDEHL----DEDKHFVVALYDYTAMNDRDLQMLKG 82
           S+  K   PLPP    + +   P PP+         +   VVALYDY  MN  DLQ+ KG
Sbjct: 179 SSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKG 238

Query: 83  EKLQVLKGTG-DWWLARSLVTGREGYVPSNFVARVE-SLEMERWFFRSQGRKEAERQLLA 140
           ++  +L+ +   WW AR    G+EGY+PSN+V   E S+EM  W+ +   R +AE QLL 
Sbjct: 239 DEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLK 296

Query: 141 PINKAGSFLIRESETNKGAFSLSVKDVTT---QGELIKHYKIRCLDEGGYYISPRITFPS 197
              K G F++R+S +  G +++SV   +T   QG +I+HY +    +  YY++ +  F +
Sbjct: 297 QEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQG-VIRHYVVCSTPQSQYYLAEKHLFST 354

Query: 198 LQALVQHYSKKGDGLCQRLTLPCVRPAPQNP----WAQDEWEIPRQSLRLVRKLGSGQFG 253
           +  L+ ++     GL  RL  P  +     P         WEI  + L  +++LG+GQFG
Sbjct: 355 IPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFG 414

Query: 254 EVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVT 312
            V  G ++    VAIK +KEG+MS + F+ EA VM  L HE+LV+LY V TK+ PI+I+T
Sbjct: 415 VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIIT 474

Query: 313 EYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEAL 372
           EYMA GCLL++L+ +   R    +L++M   + E M Y+E    +HRDL A N LV++  
Sbjct: 475 EYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG 533

Query: 373 CCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTY 431
             K++DFGL+R ++D EYT+  G+KFP++W+ PE + +  F+ K+D+W+FGVL+ E+ + 
Sbjct: 534 VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL 593

Query: 432 GRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE 491
           G++PY   +N E   ++ +G R+ RP     ++Y  ++  CW  + +ERPTF+ L S + 
Sbjct: 594 GKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYT-IMYSCWHEKADERPTFKILLSNIL 652

Query: 492 D 492
           D
Sbjct: 653 D 653


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  305 bits (782), Expect = 5e-83
 Identities = 179/479 (37%), Positives = 271/479 (56%), Gaps = 29/479 (6%)

Query: 22  QWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLK 81
           Q+ P K +++     PLPP    N      P+E +      V+ALYDY   + ++L + +
Sbjct: 145 QYDPTKNASKK----PLPPTPEDNRRPLWEPEETV------VIALYDYQTNDPQELALRR 194

Query: 82  GEKLQVLKGTG-DWWLARSLVTGREGYVPSNFVARVE--SLEMERWFFRSQGRKEAERQL 138
            E+  +L  +   WW  +    G EGYVPS+++      +LE   W+ +S  R +AE+ L
Sbjct: 195 NEEYCLLDSSEIHWWRVQDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEK-L 252

Query: 139 LAPINKAGSFLIRESETNKGAFSLSVKD---VTTQGELIKHYKIRCLDEGG--YYISPRI 193
           L    K G+F++R+S T  G +++SV     V+     IKHY I+  ++    YY++ + 
Sbjct: 253 LLDTGKEGAFMVRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKY 311

Query: 194 TFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQD----EWEIPRQSLRLVRKLGS 249
            F S+  L+ ++   G GL  RL  P      + P        +W I    L  V+++GS
Sbjct: 312 VFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGS 371

Query: 250 GQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PI 308
           GQFG V +GY+ N  KVAIKT++EG MS E F+ EA VM  L H +LV+LY V  ++ PI
Sbjct: 372 GQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPI 431

Query: 309 YIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILV 368
            +V E+M  GCL D+L+T  G   +   L+ M   + EGMAY+E    IHRDL A N LV
Sbjct: 432 CLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLV 490

Query: 369 SEALCCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLME 427
            E    K++DFG+ R ++D +YT+  G KFP+KW +PE   F  ++ K+DVWSFGVL+ E
Sbjct: 491 GENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWE 550

Query: 428 VVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFL 486
           V + G++PY   SN EV+ ++  G+R+ +P      +Y+ ++  CW+ RPE+RP F  L
Sbjct: 551 VFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ-IMNHCWKERPEDRPAFSRL 608


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  293 bits (749), Expect = 3e-79
 Identities = 174/445 (39%), Positives = 260/445 (58%), Gaps = 27/445 (6%)

Query: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGTGD--WWLARSLVTGREGYVPSNFVARVES--- 118
           +A Y++    ++DL   KG+ L ++  T D  W+ A++ V GREG +P+N+V + E    
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKA 73

Query: 119 ---LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIK 175
              L +  WF     R++AER L  P  + G FL+RES    G ++L V   +  G+ ++
Sbjct: 74  GTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCV---SCDGK-VE 127

Query: 176 HYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRP---APQNPWAQD 232
           HY+I         I   + F +L  LV+HY+   DGLC RL  P V     A Q+ + + 
Sbjct: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186

Query: 233 EWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQ 292
            W +  + L+L++ +G G+FG+V +G Y+ N KVA+K +K    + +AFL EA+VM  L+
Sbjct: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQLR 244

Query: 293 HERLVRLYAVVTKEP--IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAY 350
           H  LV+L  V+ +E   +YIVTEYMA+G L+D+L++   S L    L+  S  + E M Y
Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304

Query: 351 IERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFG 410
           +E  N +HRDL A N+LVSE    K++DFGL +   S    Q+  K P+KWTAPEA+   
Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---TQDTGKLPVKWTAPEALREK 361

Query: 411 VFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIA 470
            F+ K+DVWSFG+LL E+ ++GRVPYP +   +V+  +E+GY+M  PD CPP +Y  V+ 
Sbjct: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE-VMK 420

Query: 471 ECWRSRPEERPTFEFLQSVLEDFYT 495
            CW      RP+F  L+  LE   T
Sbjct: 421 NCWHLDAAMRPSFLQLREQLEHIKT 445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,898,258
Number of Sequences: 37866
Number of extensions: 1018077
Number of successful extensions: 5476
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 310
Number of HSP's that attempted gapping in prelim test: 3012
Number of HSP's gapped (non-prelim): 1276
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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