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Search of human proteins with 33469929
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33469929 EGF-like, fibronectin type III and laminin G
domains isoform 1 [Homo sapiens]
(1009 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 2074 0.0
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 1596 0.0
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 774 0.0
gi|54873613 agrin [Homo sapiens] 332 8e-91
gi|33469937 EGF-like, fibronectin type III and laminin G domains... 313 7e-85
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 306 5e-83
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 191 2e-48
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 142 2e-33
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 131 3e-30
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 126 1e-28
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 124 6e-28
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 114 4e-25
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 113 1e-24
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 110 5e-24
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 105 2e-22
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 101 4e-21
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 100 9e-21
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 100 1e-20
gi|188528675 slit homolog 1 [Homo sapiens] 92 2e-18
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 89 3e-17
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 88 5e-17
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 87 6e-17
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 86 1e-16
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 85 3e-16
gi|4759146 slit homolog 2 [Homo sapiens] 84 5e-16
gi|110349719 titin isoform N2-A [Homo sapiens] 81 4e-15
gi|110349717 titin isoform novex-2 [Homo sapiens] 81 4e-15
gi|110349713 titin isoform novex-1 [Homo sapiens] 81 4e-15
gi|110349715 titin isoform N2-B [Homo sapiens] 81 4e-15
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 80 1e-14
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 2074 bits (5374), Expect = 0.0
Identities = 1009/1009 (100%), Positives = 1009/1009 (100%)
Query: 1 MDLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRH 60
MDLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRH
Sbjct: 1 MDLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRH 60
Query: 61 PGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
PGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA
Sbjct: 61 PGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF
Sbjct: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
Query: 181 IRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPE 240
IRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPE
Sbjct: 181 IRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPE 240
Query: 241 EAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSIS 300
EAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSIS
Sbjct: 241 EAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSIS 300
Query: 301 NPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVN 360
NPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVN
Sbjct: 301 NPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVN 360
Query: 361 DYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAE 420
DYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAE
Sbjct: 361 DYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAE 420
Query: 421 DGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDG 480
DGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDG
Sbjct: 421 DGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDG 480
Query: 481 LNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAV 540
LNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAV
Sbjct: 481 LNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAV 540
Query: 541 NGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRH 600
NGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRH
Sbjct: 541 NGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRH 600
Query: 601 CEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKD 660
CEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKD
Sbjct: 601 CEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKD 660
Query: 661 FLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGM 720
FLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGM
Sbjct: 661 FLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGM 720
Query: 721 AEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN 780
AEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN
Sbjct: 721 AEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN 780
Query: 781 VENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY 840
VENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY
Sbjct: 781 VENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY 840
Query: 841 DNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLG 900
DNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLG
Sbjct: 841 DNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLG 900
Query: 901 SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG 960
SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG
Sbjct: 901 SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG 960
Query: 961 MKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1009
MKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Sbjct: 961 MKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1009
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 1596 bits (4133), Expect = 0.0
Identities = 771/771 (100%), Positives = 771/771 (100%)
Query: 239 PEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMS 298
PEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMS
Sbjct: 5 PEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMS 64
Query: 299 ISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFC 358
ISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFC
Sbjct: 65 ISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFC 124
Query: 359 VNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAE 418
VNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAE
Sbjct: 125 VNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAE 184
Query: 419 AEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYR 478
AEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYR
Sbjct: 185 AEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYR 244
Query: 479 DGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSL 538
DGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSL
Sbjct: 245 DGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSL 304
Query: 539 AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG 598
AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG
Sbjct: 305 AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG 364
Query: 599 RHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS 658
RHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS
Sbjct: 365 RHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS 424
Query: 659 KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE 718
KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE
Sbjct: 425 KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE 484
Query: 719 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 778
GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG
Sbjct: 485 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 544
Query: 779 VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 838
VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL
Sbjct: 545 VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 604
Query: 839 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 898
TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN
Sbjct: 605 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 664
Query: 899 LGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYV 958
LGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYV
Sbjct: 665 LGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYV 724
Query: 959 GGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1009
GGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Sbjct: 725 GGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 775
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 774 bits (1999), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 635 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 694
MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
Query: 695 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 754
WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP
Sbjct: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 120
Query: 755 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 814
FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF
Sbjct: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
Query: 815 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 874
EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD
Sbjct: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
Query: 875 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 934
SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD
Sbjct: 241 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
Query: 935 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 994
DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV
Sbjct: 301 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 360
Query: 995 EDAVDGKNINTCGAK 1009
EDAVDGKNINTCGAK
Sbjct: 361 EDAVDGKNINTCGAK 375
Score = 172 bits (435), Expect = 2e-42
Identities = 117/384 (30%), Positives = 193/384 (50%), Gaps = 28/384 (7%)
Query: 409 FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKL 468
F+IT FR ++ DG+LLY + G DF+S+ + ++FRF+CG+G ++ SE + L
Sbjct: 3 FEIT--FRPDSGDGVLLYSYDT--GSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
Query: 469 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 528
G WH + + R NG+LQ++ V G ++G +++I T +++GG P+ + + +G
Sbjct: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
Query: 529 RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSY 588
+ F G +Q + +N R I ++ SG +V E ++ C A C HGG+C K + Y
Sbjct: 119 KPFSGSIQKIILNDRTIHVK----HDFTSGVNV-ENAAHPCVRAPCAHGGSCRPRK-EGY 172
Query: 589 ICLCPLGFKGRHCEDAF--TLTIPQFRESLRSYAATPWP-----LEPQHYLSFMEFEITF 641
C CPLGF+G HC+ A + IPQF RSY P + FM F+ T
Sbjct: 173 DCDCPLGFEGLHCQKAIIEAIEIPQFIG--RSYLTYDNPDILKRVSGSRSNVFMRFKTTA 230
Query: 642 RPDSGDGVLLYSYDT---GSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHEL 698
+ DG+LL+ D+ + DF+S+ L G + F ++ GSG + G WH +
Sbjct: 231 K----DGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRV 286
Query: 699 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGS 758
+ R ++G + VD G + G Q+ N +++GG+ + N ++ G
Sbjct: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-ALHTNRQYMRGLVGC 345
Query: 759 IQKIILN-DRTIHVKHDFTSGVNV 781
I L+ D I + D G N+
Sbjct: 346 ISHFTLSTDYHISLVEDAVDGKNI 369
Score = 95.9 bits (237), Expect = 2e-19
Identities = 78/275 (28%), Positives = 125/275 (45%), Gaps = 23/275 (8%)
Query: 303 KTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDY 362
K S ++ P S S+ + + I ++ +GV + + PC C+ C
Sbjct: 112 KKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH--PCVRAPCAHGGSCRPRK 169
Query: 363 TWGGSRCQCTLGKGGESCSEDIV--IQYPQFFGHSYVTFEP---LKN-SYQAFQITLEFR 416
G C C LG G C + I+ I+ PQF G SY+T++ LK S + + F+
Sbjct: 170 E--GYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFK 227
Query: 417 AEAEDGLLLYCGENE-HGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVM 475
A+DGLLL+ G++ DF+SL + +L F +N G+GVA I+ G WH V
Sbjct: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVK 287
Query: 476 LYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN----RGF 531
RDG +G + +++ TG+S G ++ LY+GG A TN RG
Sbjct: 288 AVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-----ALHTNRQYMRGL 342
Query: 532 QGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSS 566
GC+ ++ D + A+ G ++ C +
Sbjct: 343 VGCISHFTLS---TDYHISLVEDAVDGKNINTCGA 374
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 332 bits (852), Expect = 8e-91
Identities = 235/764 (30%), Positives = 356/764 (46%), Gaps = 69/764 (9%)
Query: 301 NPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVN 360
+P S+ + T+A+ P T P P + G+ A PCD C C +
Sbjct: 1290 HPSHTSQPVAKTTAA-PTTRRPPTTAPSRVPGRRPPAPQQP--PKPCDSQPCFHGGTCQD 1346
Query: 361 DYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAE 420
GG C C G+GG C + + P F G S++ F L+ +Y ++ LEFRA
Sbjct: 1347 WALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLR-AYHTLRLALEFRALEP 1405
Query: 421 DGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDG 480
GLLLY G N G+ DF++LA++ +Q RF+ G+G A++ S ++ G WH + L R
Sbjct: 1406 QGLLLYNG-NARGK-DFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHW 1463
Query: 481 LNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPS--AYWLVRATGTNRGFQGCVQSL 538
G L ++ TPV G+S + T L++GG P A + T G +GC++ L
Sbjct: 1464 RRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLL 1523
Query: 539 AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG 598
VN +R+++ P G A G+ VGEC C C G C ++A + C CP G G
Sbjct: 1524 DVNNQRLELGIGP-GAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVG 1582
Query: 599 RHC----------------------EDAFTLTIPQFRESLRSYAATPWP----------- 625
C E P RE A+
Sbjct: 1583 PTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNG 1642
Query: 626 ---LEPQHYLSF-------MEFEITFRPDSGDGVLLYSYDT--GSKDFLSINLAGGHVEF 673
LE + +F M E+ F G+LLY+ G DF+S+ L +EF
Sbjct: 1643 FSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEF 1702
Query: 674 RFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTD 733
R+D G G V+RS +P+TLG W + + R + G L+V V G + T +
Sbjct: 1703 RYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEP 1762
Query: 734 IFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN-AAHPCVRA- 791
+++GG P++ + + + V F G+IQ + L R + V+V + A HPC RA
Sbjct: 1763 LYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRAS 1822
Query: 792 --PCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEA----IEIPQFIGRSYLTYDNPDI 845
PC +G SC PR+ Y C CP GF G HC+K ++E ++ F GR+++ Y N +
Sbjct: 1823 GHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNA-V 1881
Query: 846 LKRVSGSRSNVF-MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVA 904
+ +SN F + +T A GL+LW G + R +D+++L + DG L SYNLGS
Sbjct: 1882 TESEKALQSNHFELSLRTEATQGLVLWSGKATER--ADYVALAIVDGHLQLSYNLGSQPV 1939
Query: 905 SIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI 964
+ N RW RV A R+ + G + V + TG SP QL+ +GAL++GG+ E+
Sbjct: 1940 VLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPEL 1999
Query: 965 AL--HTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTC 1006
+ + Y G VGC+ + + + L+EDAV + C
Sbjct: 2000 PVGPALPKAYGTGFVGCLRDVVVGR-HPLHLLEDAVTKPELRPC 2042
>gi|33469937 EGF-like, fibronectin type III and laminin G domains
isoform 4 [Homo sapiens]
Length = 152
Score = 313 bits (801), Expect = 7e-85
Identities = 152/152 (100%), Positives = 152/152 (100%)
Query: 858 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 917
MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW
Sbjct: 1 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 60
Query: 918 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV 977
HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV
Sbjct: 61 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV 120
Query: 978 GCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1009
GCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Sbjct: 121 GCISHFTLSTDYHISLVEDAVDGKNINTCGAK 152
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/159 (29%), Positives = 76/159 (47%), Gaps = 13/159 (8%)
Query: 413 LEFRAEAEDGLLLYCGENE-HGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGW 471
+ F+ A+DGLLL+ G++ DF+SL + +L F +N G+GVA I+ G W
Sbjct: 1 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 60
Query: 472 HTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN--- 528
H V RDG +G + +++ TG+S G ++ LY+GG A TN
Sbjct: 61 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-----ALHTNRQY 115
Query: 529 -RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSS 566
RG GC+ ++ D + A+ G ++ C +
Sbjct: 116 MRGLVGCISHFTLS---TDYHISLVEDAVDGKNINTCGA 151
Score = 56.6 bits (135), Expect = 1e-07
Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 5/145 (3%)
Query: 641 FRPDSGDGVLLYSYDTGSK---DFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 697
F+ + DG+LL+ D+ + DF+S+ L G + F ++ GSG + G WH
Sbjct: 3 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHR 62
Query: 698 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSG 757
++ R ++G + VD G + G Q+ N +++GG+ + N ++ G
Sbjct: 63 VKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-ALHTNRQYMRGLVG 121
Query: 758 SIQKIILN-DRTIHVKHDFTSGVNV 781
I L+ D I + D G N+
Sbjct: 122 CISHFTLSTDYHISLVEDAVDGKNI 146
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 306 bits (785), Expect = 5e-83
Identities = 205/711 (28%), Positives = 319/711 (44%), Gaps = 121/711 (17%)
Query: 385 VIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENE---------HGRG 435
V+ Y +S++ +K++Y+ F+I + FR ++ DG+LLY G+ + +
Sbjct: 3662 VVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQP 3721
Query: 436 DFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTG 495
DF+S ++ +FRF+ G+G+A I T + LG +HTV L R G L + + PV G
Sbjct: 3722 DFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNG 3781
Query: 496 QSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKA 555
SQG++ + LYLGG P Y + G + GF GCV+ L + G I L
Sbjct: 3782 TSQGKFQGLDLNEELYLGGYPD-YGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNL--- 3837
Query: 556 LSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE------------- 602
+ + C + C + C +GG C ++ SY+C+CP GF G CE
Sbjct: 3838 -TAHGISHCPT--CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACG 3894
Query: 603 ----------------------------DAFTLTIPQFRESLRSYAATPWPLEPQHYLSF 634
+ T+T P SY A P H L
Sbjct: 3895 PDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSL-SGAGSYLALPALTNTHHEL-- 3951
Query: 635 MEFEITFRPDSGDGVLLYSYDTGS--KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 692
++ F+P + DGVLL+S +DF+S+ + GGH+EFR++ GSG VLRS +PL L
Sbjct: 3952 -RLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLAL 4010
Query: 693 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 752
G WH + R K+G L+V+ + V + G + +T +++GGV + + +
Sbjct: 4011 GRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMS 4070
Query: 753 KPFSGSIQKIILNDRTIHVKHDF--TSGVNVENAAHPCVRAPCAHGGSCRPRKE------ 804
F G + ++ +N + + + + F + G+ + PC R PC HG +C P E
Sbjct: 4071 AHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCL 4130
Query: 805 ------------------------------GYDCDCPLGFEGLHCQKAIIEAI------- 827
G C C GF G CQ+ I
Sbjct: 4131 CRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHL 4190
Query: 828 ------EIPQFIGR-----SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDS- 875
+ P G +L + + + + + +T+ GLLLW+G
Sbjct: 4191 EGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEV 4250
Query: 876 -PMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 934
DFISLGL+DG LVF Y LGSG A ++ NDG WHRV A+R+G+ G I VD
Sbjct: 4251 GEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVD 4310
Query: 935 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 985
+G+SPG +N G++Y+GG ++A T ++ G+ GC+ + L
Sbjct: 4311 GEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
Score = 216 bits (549), Expect = 1e-55
Identities = 149/514 (28%), Positives = 231/514 (44%), Gaps = 84/514 (16%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGH-SYVTFEPLKNS 405
C C D+ CVN G C+C LG+ G C E + + P G SY+ L N+
Sbjct: 3888 CHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNT 3947
Query: 406 YQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 465
+ ++ +EF+ A DG+LL+ G DF+SLA++ L+FR+ G+G+A++ S
Sbjct: 3948 HHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEP 4007
Query: 466 IKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRAT 525
+ LG WH V R +G L++N G PV S G+ + T LYLGG + L AT
Sbjct: 4008 LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPAT 4067
Query: 526 GTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC-SSGICDEASCIHGGTCTAIK 584
+ F+GCV ++VNG+R+D+ LG +G+C S C+ C HG TC
Sbjct: 4068 NMSAHFRGCVGEVSVNGKRLDLTYSFLG----SQGIGQCYDSSPCERQPCQHGATCMPAG 4123
Query: 585 ADSYICLCPLGFKGRHCE-------------------DAFTLTIPQF------RESLRSY 619
+ CLC GFKG CE L +P F + S
Sbjct: 4124 EYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGI 4183
Query: 620 AATPWPLE-------PQHYLSFME----------------------FEITFRPDSGDGVL 650
A + W LE P Y ++ E+ R + G+L
Sbjct: 4184 AESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLL 4243
Query: 651 LY-SYDTG----SKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAK 705
L+ + G KDF+S+ L GH+ FR+ GSG L SEDP+ G WH + R +
Sbjct: 4244 LWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGR 4303
Query: 706 NGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV---KKNSGVLKPFSGSIQKI 762
G +QVD +++V G + G + ++IGG P+ + + +SG+ +G ++ +
Sbjct: 4304 RGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGI----TGCVKNL 4359
Query: 763 ILND--------RTIHVKHDFTSGVNVENAAHPC 788
+L+ + + ++H +G N PC
Sbjct: 4360 VLHSARPGAPPPQPLDLQHRAQAGAN----TRPC 4389
Score = 86.3 bits (212), Expect = 1e-16
Identities = 76/254 (29%), Positives = 109/254 (42%), Gaps = 40/254 (15%)
Query: 348 DETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSE-------------------DIVIQY 388
+E C C++ T G+RC C G G C + D QY
Sbjct: 4143 EENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQY 4202
Query: 389 PQFF---------GHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCG--ENEHGRG-D 436
+F GH + P I LE R GLLL+ G E G+G D
Sbjct: 4203 GAYFHDDGFLAFPGHVFSRSLPEVPE----TIELEVRTSTASGLLLWQGVEVGEAGQGKD 4258
Query: 437 FMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ 496
F+SL + L FR+ G+G A +VSE I G WH V R+G G +Q++ V+G+
Sbjct: 4259 FISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGR 4318
Query: 497 SQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLG-- 553
S G + + +Y+GGAP L ++ G GCV++L ++ R P PL
Sbjct: 4319 SPGPNVAVNAKGSVYIGGAPDVATLTGGRFSS-GITGCVKNLVLHSARPGAPPPQPLDLQ 4377
Query: 554 -KALSGADVGECSS 566
+A +GA+ C S
Sbjct: 4378 HRAQAGANTRPCPS 4391
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 191 bits (486), Expect = 2e-48
Identities = 178/749 (23%), Positives = 312/749 (41%), Gaps = 126/749 (16%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQF-----FGH-SYVTFE 400
C+ C + CV + C C G+ G C++ I I P+F FG+ S++ +
Sbjct: 2375 CENNPCGNGATCVPK-SGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYS 2433
Query: 401 PLKNSYQAFQITLEFR-----AEAEDGLLLYCGENEHGRG--DFMSLAIIRRSLQFRFNC 453
+ + ++ L+F+ + ++ L+ + G+ HG DF+++ ++ S+ + +N
Sbjct: 2434 RISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNL 2493
Query: 454 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLG 513
G+G+A I SE G HTV L + G L++++ + + G+ + + Y+G
Sbjct: 2494 GSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVG 2553
Query: 514 GAPSAYW---LVRATGTNRGFQGCVQSLAVNGRRIDMRPW---PLGKALSGADVGECSSG 567
G S Y L GFQGC+ +L V + P G +G VG+C +
Sbjct: 2554 GY-SEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHAS 2612
Query: 568 ICDEASCIHGGTC----------------------TAIKAD------------------- 586
C C +GGTC T D
Sbjct: 2613 PCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLP 2672
Query: 587 -SYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDS 645
Y C CPLG G +CE A +++ P FR + S+ + H ++ F+P +
Sbjct: 2673 HGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMS----FASFHVRKKTHIQLQFQPLA 2728
Query: 646 GDGVLLYS---YDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL--GNWHELRV 700
DG+L Y+ S DFL I+L V+ R++ G T +L + +T+ WH ++
Sbjct: 2729 ADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKA 2788
Query: 701 SRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP--FSGS 758
R G L +D + E A + + NTD +IGGV + + V + +P F G
Sbjct: 2789 GRVGAEGYLDLDGINVTE-KASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGC 2847
Query: 759 IQKIILNDRTIHVKHDFTSG---------------------------------------V 779
I+++I+N++ + + G
Sbjct: 2848 IRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAG 2907
Query: 780 NVENAAHPCVRAPCAHGGSCRPRKE-GYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 838
N N + C+ C H C P + Y C C LG+ G +C+ + +F+G SY+
Sbjct: 2908 NTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENK--TSFSTAKFMGNSYI 2965
Query: 839 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 898
Y +P+ R + + + + F TT +GL++W G + N DF+++GL + L + N
Sbjct: 2966 KYIDPNYRMR-NLQFTTISLNFSTTKTEGLIVWMGIAQNEEN-DFLAIGLHNQTLKIAVN 3023
Query: 899 LGSGVASIMV--NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMR--QLNING 954
LG ++ M NG+F +WH V +++ K +++ + LN +G
Sbjct: 3024 LGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDG 3083
Query: 955 ALYVGGM---KEIALHTNRQYMRGLVGCI 980
Y+GG +++ + T + VG I
Sbjct: 3084 ICYLGGFEYGRKVNIVTQEIFKTNFVGKI 3112
Score = 157 bits (397), Expect = 5e-38
Identities = 180/841 (21%), Positives = 324/841 (38%), Gaps = 151/841 (17%)
Query: 295 KKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSA 354
K I+N ++ ++ PT++ + + V + VA S C + +C
Sbjct: 2056 KNYHINNCRSQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPS-----VCQQDVCHN 2110
Query: 355 DSFCVNDYTWGGS---RCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLK-----NSY 406
C + G +C C L G C +D + +P F G+SY+ LK
Sbjct: 2111 GGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEKEHN 2170
Query: 407 QAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKI 466
+ I L + + +G +LY N G+ F+ L ++ ++ CG I+
Sbjct: 2171 RTVTIYLTIKTNSLNGTILYSNGNNCGK-QFLHLFLVEGRPSVKYGCGNSQNILTVSANY 2229
Query: 467 KLGG--------WHTVMLYRDGLNGLLQLN-NGTPVTGQSQGQYSKIT--FRTPLYLGGA 515
+ +T + G+ ++++ +G P + + S + + ++LG
Sbjct: 2230 SINTNAFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHI 2289
Query: 516 PSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC----------- 564
P+ + + G GF+GC+ L VN + + + +A G ++ C
Sbjct: 2290 PANVQIHKKAGPVYGFRGCILDLQVNNKEFFI----IDEARHGKNIENCHVPWCAHHLCR 2345
Query: 565 --------------------SSGICDEASCIH-----GGTCTAIKADSYICLCPLGFKGR 599
S +C ASC + G TC +CLCP G G
Sbjct: 2346 NNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGP 2405
Query: 600 HCEDAFTLTIPQFRESLRSYAATPWPLEPQ------HYLSFMEFEITFRPDSGDGVLLY- 652
C DA +T P+F ++ T + + HY ++F++ + L++
Sbjct: 2406 LCTDAINITQPRF-SGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFF 2464
Query: 653 ----SYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLG-NWHELRVSRTAKNG 707
+ DFL++ L G V + ++ GSG +RSE PL L H + + + + G
Sbjct: 2465 TGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSE-PLNLSLGVHTVHLGKFFQEG 2523
Query: 708 ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNY-DDVKKNSGVLK-PFSGSIQKI-IL 764
L+VD K +A G + + ++GG Y D+ N K F G I + +
Sbjct: 2524 WLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVR 2583
Query: 765 NDRTIHVK-------HDFTSGVNVENAAHPCVRAPCAHGG-------------------- 797
++ H + H + A PC C +GG
Sbjct: 2584 TEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGS 2643
Query: 798 -------SCRPRKE----------------GYDCDCPLGFEGLHCQKAIIEAIEIPQFIG 834
+C P + GY C CPLG G++C++A+ +I P F
Sbjct: 2644 FCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQAL--SISDPSFRS 2701
Query: 835 R--SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGA 892
S++++ + + K ++++ ++F+ A DG+L + + DF+ + L + +
Sbjct: 2702 NELSWMSFASFHVRK-----KTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSS 2756
Query: 893 LVFSYNLGSG--VASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL 950
+ YNLG + + + N WH +KA R G G + +D T K+ M L
Sbjct: 2757 VQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINV-TEKASTKMSSL 2815
Query: 951 NINGALYVGGMKEIALHTNRQYMR----GLVGCISHFTLSTDYHISLVE-DAVDGKNINT 1005
+ N Y+GG+ + L N + G GCI ++ + + L E A G N+
Sbjct: 2816 DTNTDFYIGGVSSLNL-VNPMAIENEPVGFQGCIRQVIIN-NQELQLTEFGAKGGSNVGD 2873
Query: 1006 C 1006
C
Sbjct: 2874 C 2874
Score = 152 bits (383), Expect = 2e-36
Identities = 170/700 (24%), Positives = 281/700 (40%), Gaps = 110/700 (15%)
Query: 390 QFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEH-GRGDFMSLAIIRRSLQ 448
+++G SY+ F+ + + Q I+LEF+ + GLLLY ++ + G F+ L I +L+
Sbjct: 1887 RYYGDSYLEFQNVALNPQN-NISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLK 1945
Query: 449 FRFNCGTGVAIIVSETKIKL-GGWHTVMLYRDGLNG----LLQLNNGTPVTGQSQGQYSK 503
+ F C T +++ G +L R L+ L L T + K
Sbjct: 1946 YHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGK 2005
Query: 504 ITFRT-PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM--------------- 547
++ +++GG P + ++ + F GC++ + +N R +
Sbjct: 2006 PLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRS 2065
Query: 548 RPWPLGKALSGADVGECSSGI----------------CDEASCIHGGTCTAIKADSYI-- 589
+ + L S D + + G+ C + C +GGTC AI S I
Sbjct: 2066 QGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVS 2125
Query: 590 --CLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW---PLEPQHYLSFMEFEITFRPD 644
C CPL F GR CE L P F + SY P+ LE +H + + +T + +
Sbjct: 2126 FQCDCPLHFTGRFCEKDAGLFFPSFNGN--SYLELPFLKFVLEKEHNRTVTIY-LTIKTN 2182
Query: 645 SGDGVLLYSYDTG-SKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRT 703
S +G +LYS K FL + L G ++ CG+ +L ++ ++
Sbjct: 2183 SLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIR 2242
Query: 704 AKNGILQVDKQKIVEGMAEGGFTQIKCNTDI-----------FIGGVPNYDDVKKNSGVL 752
+ ++E A+G K +T+I F+G +P + K +G +
Sbjct: 2243 YTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPV 2302
Query: 753 KPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHP-CVRAPCAHGGSCRPRKEGYDCDCP 811
F G I + +N++ + + G N+EN P C C + G+C E C+CP
Sbjct: 2303 YGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECP 2362
Query: 812 LGFEGLHCQKAIIE---------------------------------AIEI--PQFIGRS 836
+ G CQ A E AI I P+F G
Sbjct: 2363 RLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTD 2422
Query: 837 YLTYDNPDILKRVSGSRSNVFMRFK-------TTAKDGLLLWRGDSPMRPN-SDFISLGL 888
Y + R+S + K + ++ L+ + G N DF+++GL
Sbjct: 2423 AFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGL 2482
Query: 889 RDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMR 948
+G++V+SYNLGSG+ASI H V + Q G + VDD+ ++ +PG +
Sbjct: 2483 LNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLV 2542
Query: 949 QLNINGALYVGGMKEIA---LHTNRQYMRGLVGCISHFTL 985
LN+ YVGG E L + G GCI FTL
Sbjct: 2543 GLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCI--FTL 2580
Score = 53.1 bits (126), Expect = 1e-06
Identities = 67/287 (23%), Positives = 94/287 (32%), Gaps = 38/287 (13%)
Query: 557 SGADVGECSSGI--CDEASCIHGGTC-TAIKADSYICLCPLGFKGRHCEDAFTLTIPQFR 613
SG CS I CD C++GG C + ++CLCP + G+ C + L
Sbjct: 799 SGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHN 858
Query: 614 ESLRSYAATPWPLEPQHYLSFMEFE-ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE 672
+ QH + EFE D D + L D G + + N
Sbjct: 859 PCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNN------- 911
Query: 673 FRFDCGSGTGVLRSEDPLTLGNWHELRV----SRTAKNGILQVDKQKIVEGMAEGGFTQI 728
FR C G G+ E+ + S KN VD E +
Sbjct: 912 FRCICRPGFS----------GSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGP 961
Query: 729 KCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC 788
C D+ N + P + D + +G+N E C
Sbjct: 962 FCELDV-------------NKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDEC 1008
Query: 789 VRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR 835
+ PC H G C Y CDC GF G HC+ + + P GR
Sbjct: 1009 LSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGR 1055
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 788 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIE 828
C PC + G C+ G+ C CP G+ G +C+K+I E
Sbjct: 1083 CTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAE 1123
Score = 42.0 bits (97), Expect = 0.003
Identities = 17/47 (36%), Positives = 22/47 (46%)
Query: 777 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 823
SG E + C +PC HG C GY C C G+ G HC+ +
Sbjct: 1154 SGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL 1200
Score = 39.3 bits (90), Expect = 0.019
Identities = 36/148 (24%), Positives = 55/148 (37%), Gaps = 35/148 (23%)
Query: 701 SRTAKNGILQVDKQ-----------KIVEG---MAEGGFTQIKCNTDIFIGGVPNYDDVK 746
S KNG +D+ K+V+G + G+ I+C DI DD
Sbjct: 687 SHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDI--------DDCI 738
Query: 747 KNS----GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPR 802
N+ K S Q + L+D G E ++ C PC + +C
Sbjct: 739 LNACEHNSTCKDLHLSYQCVCLSD---------WEGNFCEQESNECKMNPCKNNSTCTDL 789
Query: 803 KEGYDCDCPLGFEGLHCQKAIIEAIEIP 830
+ Y C+C G+ G +C + I E P
Sbjct: 790 YKSYRCECTSGWTGQNCSEEINECDSDP 817
Score = 37.4 bits (85), Expect = 0.072
Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 6/44 (13%)
Query: 560 DVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCED 603
++ ECSS + C+HG C + Y+C C G+ G HCE+
Sbjct: 1161 NINECSS-----SPCLHGADCED-HINGYVCKCQPGWSGHHCEN 1198
Score = 34.7 bits (78), Expect = 0.46
Identities = 38/196 (19%), Positives = 83/196 (42%), Gaps = 17/196 (8%)
Query: 820 QKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRP 879
Q+ +I ++ G SYL + N + ++N+ + F+T + GLLL+
Sbjct: 1876 QRLMISDFSCVRYYGDSYLEFQNVAL-----NPQNNISLEFQTFSSYGLLLYVKQDSNLV 1930
Query: 880 NSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHR----VKAVRDGQSGKITVDD 935
+ FI L + +G L + + +N + + ++ D + ++T+
Sbjct: 1931 DGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILG 1990
Query: 936 YGARTGKSPG--MMRQLNINGALYVGGMKEIALHTNRQY---MRGLVGCISHFTLSTDYH 990
+ +S + + L +G++++GG + LH Q ++ GCI ++ ++
Sbjct: 1991 RNTQICESINHVLGKPLPKSGSVFIGGFPD--LHGKIQMPVPVKNFTGCIEVIEIN-NWR 2047
Query: 991 ISLVEDAVDGKNINTC 1006
+ AV +IN C
Sbjct: 2048 SFIPSKAVKNYHINNC 2063
Score = 33.5 bits (75), Expect = 1.0
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 5/72 (6%)
Query: 534 CVQSLAVNGRRIDM-RPWPLGKALSGADVGECSSGI--CDEASCIHGGTCTAIKADSYIC 590
C+ + ++GR ++ +P G +C I C C++ G C A + C
Sbjct: 1046 CLSNPCLHGRCTELINEYPCSCDADGTST-QCKIKINDCTSIPCMNEGFCQK-SAHGFTC 1103
Query: 591 LCPLGFKGRHCE 602
+CP G+ G +CE
Sbjct: 1104 ICPRGYTGAYCE 1115
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 567 GICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 602
G C C HG C+ I ++S+IC C F G CE
Sbjct: 258 GQCQPHVCFHGN-CSNITSNSFICECDEQFSGPFCE 292
Score = 32.3 bits (72), Expect = 2.3
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDI 384
C C +S C + Y RC+CT G G++CSE+I
Sbjct: 775 CKMNPCKNNSTCTDLYK--SYRCECTSGWTGQNCSEEI 810
Score = 32.3 bits (72), Expect = 2.3
Identities = 12/42 (28%), Positives = 20/42 (47%)
Query: 561 VGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 602
+ C+ + C++GG C ++ C C GF G+ CE
Sbjct: 1118 IDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCE 1159
Score = 31.6 bits (70), Expect = 3.9
Identities = 12/36 (33%), Positives = 19/36 (52%)
Query: 788 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 823
C P + +C+ ++ Y C C GF +C+KAI
Sbjct: 374 CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 142 bits (358), Expect = 2e-33
Identities = 145/527 (27%), Positives = 209/527 (39%), Gaps = 84/527 (15%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 406
C +C CVN GG +C C G + + +P HS++TF L+ +
Sbjct: 1332 CTPGVCKNGGTCVNLLV-GGFKCDCPSGDFEKPYCQVTTRSFP---AHSFITFRGLRQRF 1387
Query: 407 QAFQITLEFRAEAEDGLLLYCGE-NEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 465
F + L F + DGLLLY G NE + DF++L +I+ +Q F+ G +
Sbjct: 1388 H-FTLALSFATKERDGLLLYNGRFNE--KHDFVALEVIQEQVQLTFSAGESTTTVSPFVP 1444
Query: 466 --IKLGGWHTVML--YRDGLNGLLQLNNGTP----------------------------- 492
+ G WHTV L Y L G L G
Sbjct: 1445 GGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSC 1504
Query: 493 -VTGQSQGQYSKITFRTPLYLGGAPSA--YWLVRATGTNRGFQGCVQSLAVNGRRIDMRP 549
G G + PL LGG P + VR R F GC+++L V+ R IDM
Sbjct: 1505 AAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRM----RQFVGCMRNLQVDSRHIDMAD 1560
Query: 550 WPLGKALSGADVG-ECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLT 608
+ A +G G +CD +C +GGTC + D++ C CPLGF G+ C
Sbjct: 1561 FI---ANNGTVPGCPAKKNVCDSNTCHNGGTCVN-QWDAFSCECPLGFGGKSCAQEMANP 1616
Query: 609 IPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAG 668
SL ++ P+ YLS M FR DGVLL + G + +++ L
Sbjct: 1617 QHFLGSSLVAWHGLSLPISQPWYLSLM-----FRTRQADGVLLQAITRG-RSTITLQLRE 1670
Query: 669 GHVEFRFDCGSGTGVLRSEDPL-----TLGNWHELRVSRTAKNG----ILQVD-KQKIVE 718
GHV + GTG+ S L G+WH +++ A G IL D Q+ E
Sbjct: 1671 GHVMLSVE---GTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAE 1727
Query: 719 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKH---DF 775
G + ++I +GG+P GV + F G +Q + ++D V
Sbjct: 1728 GNLGPRLHGLHL-SNITVGGIPG-----PAGGVARGFRGCLQGVRVSDTPEGVNSLDPSH 1781
Query: 776 TSGVNVENAA---HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHC 819
+NVE PC PC C + Y C C G+ G +C
Sbjct: 1782 GESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC 1828
Score = 82.0 bits (201), Expect = 3e-15
Identities = 111/487 (22%), Positives = 190/487 (39%), Gaps = 77/487 (15%)
Query: 566 SGICDEASCIHGGTCTAIKADSYICLCPLG-FKGRHCEDAFTLTIPQFRESLRSYAATPW 624
SG C C +GGTC + + C CP G F+ +C+ T + P S+
Sbjct: 1329 SGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQ-VTTRSFPA-----HSFITFRG 1382
Query: 625 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSK-DFLSINLAGGHVEFRFDCGSGTGV 683
+ H+ + F R DG+LLY+ K DF+++ + V+ F G T
Sbjct: 1383 LRQRFHFTLALSFATKER----DGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTT 1438
Query: 684 LRSEDP--LTLGNWHELRVSRTAKNGILQV------DKQKIV------------------ 717
+ P ++ G WH +++ K + Q +QK+
Sbjct: 1439 VSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSV 1498
Query: 718 --------EGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV-LKPFSGSIQKIILNDRT 768
+G G + + +GGVP D+ ++ V ++ F G ++ + ++ R
Sbjct: 1499 LGNYSCAAQGTQGGSKKSLDLTGPLLLGGVP---DLPESFPVRMRQFVGCMRNLQVDSRH 1555
Query: 769 IHVKHDFTSGVNVENAA---HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIE 825
I + + V + C C +GG+C + + + C+CPLGF G C + E
Sbjct: 1556 IDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQ---E 1612
Query: 826 AIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFIS 885
F+G S + + L + + F+T DG+LL + I+
Sbjct: 1613 MANPQHFLGSSLVAWHG---LSLPISQPWYLSLMFRTRQADGVLL----QAITRGRSTIT 1665
Query: 886 LGLRDGALVFSYNLGSGVASIMVN---GSFNDGRWHRVKAVRDGQSG---KITVDDYGAR 939
L LR+G ++ S G+G+ + + G NDG WH + G I DYG +
Sbjct: 1666 LQLREGHVMLSVE-GTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQ 1724
Query: 940 --TGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDA 997
G + L+++ + VGG+ A RG GC+ +S D
Sbjct: 1725 RAEGNLGPRLHGLHLSN-ITVGGIPGPA----GGVARGFRGCLQGVRVSDTPEGVNSLDP 1779
Query: 998 VDGKNIN 1004
G++IN
Sbjct: 1780 SHGESIN 1786
Score = 67.8 bits (164), Expect = 5e-11
Identities = 79/312 (25%), Positives = 112/312 (35%), Gaps = 60/312 (19%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQ-FFGHSYVTFEPLKNS 405
CD C CVN W C+C LG GG+SC++++ PQ F G S V + L
Sbjct: 1578 CDSNTCHNGGTCVNQ--WDAFSCECPLGFGGKSCAQEMA--NPQHFLGSSLVAWHGLSLP 1633
Query: 406 Y-QAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV---AIIV 461
Q + ++L FR DG+LL RG +R GTG+ ++ +
Sbjct: 1634 ISQPWYLSLMFRTRQADGVLL----QAITRGRSTITLQLREGHVMLSVEGTGLQASSLRL 1689
Query: 462 SETKIKLGGWHTVMLYRDGLNG----LLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPS 517
+ G WH L G +L + G + G + + +GG P
Sbjct: 1690 EPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPG 1749
Query: 518 AYWLVRATGTNRGFQGCVQSLAV-------------NGRRI------------DMRPWPL 552
A G RGF+GC+Q + V +G I D P P
Sbjct: 1750 P-----AGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPA 1804
Query: 553 GKALSGA-DVGECS----------SGICDEASCIHGGTCTAIKA--DSYICLCPLGFKGR 599
S D CS + +CD C H CT + Y C CP + G
Sbjct: 1805 NSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGP 1864
Query: 600 HCEDAFTLTIPQ 611
+CE P+
Sbjct: 1865 YCETRIDQPCPR 1876
Score = 57.8 bits (138), Expect = 5e-08
Identities = 66/298 (22%), Positives = 107/298 (35%), Gaps = 69/298 (23%)
Query: 777 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP------ 830
+G E C PC G CR R+ GY C C G+ G HC+ + P
Sbjct: 1281 TGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNG 1340
Query: 831 -------------------------QFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAK 865
Q RS+ + + + F T +
Sbjct: 1341 GTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKER 1400
Query: 866 DGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI--MVNGSFNDGRWHRVKAV 923
DGLLL+ G DF++L + + +++ G ++ V G +DG+WH V+
Sbjct: 1401 DGLLLYNG--RFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLK 1458
Query: 924 RD-----GQSG-----------KITVD--DYG--------------ARTGKSPGMMRQLN 951
GQ+G +TVD D G A G G + L+
Sbjct: 1459 YYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLD 1518
Query: 952 INGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1009
+ G L +GG+ ++ + MR VGC+ + + + HI + + + + C AK
Sbjct: 1519 LTGPLLLGGVPDLP-ESFPVRMRQFVGCMRNLQVDS-RHIDMADFIANNGTVPGCPAK 1574
Score = 37.7 bits (86), Expect = 0.055
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 346 PCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCS 381
PCD C A+S+C ND W C C G G++C+
Sbjct: 1796 PCDSNPCPANSYCSND--WDSYSCSCDPGYYGDNCT 1829
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 131 bits (330), Expect = 3e-30
Identities = 163/761 (21%), Positives = 311/761 (40%), Gaps = 137/761 (18%)
Query: 306 SRLIPPTSASLPVTTVAPQ-----PIPIQRKGKNGVAIMSRLFDMPCDETLC--SADSFC 358
S+++P S + + P P +G+ GV + + + D+ +C S F
Sbjct: 192 SQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFR 251
Query: 359 VNDYTWGGSRCQ----CTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QIT 412
D + + + +G G+S ++ I F G Y ++ +N Q+ +IT
Sbjct: 252 GKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEIT 309
Query: 413 LEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLG 469
L F+ +GL+L+ G++ D+++LA+ ++ N G+G + E K
Sbjct: 310 LSFKTLQRNGLMLHTGKS----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 365
Query: 470 GWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWL 521
WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+PS L
Sbjct: 366 AWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
Query: 522 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 581
+ +N F GC++ + + + L K D IHG
Sbjct: 426 PGSPVSNN-FMGCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VV 469
Query: 582 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEIT 640
A K ++ L P+ F E+ S+ + P W + +SF
Sbjct: 470 AFKCENVATLDPITF-----------------ETPESFISLPKWNAKKTGSISF-----D 507
Query: 641 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 687
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 508 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 567
Query: 688 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 747
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 568 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 621
Query: 748 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 789
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 622 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 681
Query: 790 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 848
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 737
Query: 849 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 899
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 738 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 791
Query: 900 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 959
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 792 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 847
Query: 960 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 996
E + T R+Y+ + +G + T + +I L ++
Sbjct: 848 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 885
Score = 121 bits (304), Expect = 3e-27
Identities = 152/650 (23%), Positives = 256/650 (39%), Gaps = 101/650 (15%)
Query: 346 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 403
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 679 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 734
Query: 404 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 456
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 735 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 794
Query: 457 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 508
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 795 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 854
Query: 509 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 568
YL PS F G +QSL NG A + C +G
Sbjct: 855 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 887
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 628
D I AD P+ FK + A +L++Y +
Sbjct: 888 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 926
Query: 629 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 686
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 927 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 979
Query: 687 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 743
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 980 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1037
Query: 744 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 798
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 1038 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1097
Query: 799 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 857
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 1098 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1153
Query: 858 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 916
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 1154 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1211
Query: 917 WHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGGMKE 963
+H V+ R G + + VD + G RQL N + +GG ++
Sbjct: 1212 YHVVRFTRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIIIGGKEQ 1259
Score = 105 bits (262), Expect = 2e-22
Identities = 102/382 (26%), Positives = 161/382 (42%), Gaps = 33/382 (8%)
Query: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 914 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 969
Query: 455 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 970 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1028
Query: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 1029 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1085
Query: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 1086 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1141
Query: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 684
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 1142 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1201
Query: 685 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPNYD 743
S + G +H +R +R+ N LQVD ++E G T I IGG
Sbjct: 1202 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG----- 1256
Query: 744 DVKKNSGVLKPFSGSIQKIILN 765
K G +PF G + + N
Sbjct: 1257 ---KEQG--QPFQGQLSGLYYN 1273
Score = 103 bits (256), Expect = 1e-21
Identities = 109/404 (26%), Positives = 164/404 (40%), Gaps = 73/404 (18%)
Query: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 689
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
Query: 690 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 749
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
Query: 750 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 789
LK PF G I+ + +N + VK D + G + A
Sbjct: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
Query: 790 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKA--IIEAIE----------------IP 830
C +GG C + CDC GF G C + +E + I
Sbjct: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA 284
Query: 831 QFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 887
F G Y YD NP + S + + FKT ++GL+L G S +D+++L
Sbjct: 285 TFKGSEYFCYDLSQNP-----IQSSSDEITLSFKTLQRNGLMLHTGKS-----ADYVNLA 334
Query: 888 LRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRD--GQSG------KITVDDY 936
L++GA+ NLGSG + VNG FND WH VK R+ SG I+VD
Sbjct: 335 LKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGI 394
Query: 937 GARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 980
TG + L + YVGG A +GC+
Sbjct: 395 LTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
Score = 102 bits (253), Expect = 2e-21
Identities = 145/627 (23%), Positives = 259/627 (41%), Gaps = 114/627 (18%)
Query: 401 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 457
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
Query: 458 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 516
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
Query: 517 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 561
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
Query: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCED--------AFTLTIPQF 612
GE G C++GG C+ + D +C C GF+G+ C A + Q
Sbjct: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQG 274
Query: 613 R-ESLRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFL 662
+ + Y AT E Y S E ++F+ +G++L+ TG S D++
Sbjct: 275 KSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH---TGKSADYV 331
Query: 663 SINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAK--NGI------LQV 711
++ L G V + GSG E N WH+++V+R + +GI + V
Sbjct: 332 NLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISV 391
Query: 712 DKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHV 771
D G + +T + + ++GG P+ D+ S V F G +++++ + + +
Sbjct: 392 DGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL-PGSPVSNNFMGCLKEVVYKNNDVRL 450
Query: 772 KHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQ 831
+ R K+G D + G+ K A P
Sbjct: 451 E-------------------------LSRLAKQG---DPKMKIHGVVAFKCENVATLDP- 481
Query: 832 FIGRSYLTYDNPD----ILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS------ 881
+T++ P+ + K + ++ F+TT +GL+L+ P
Sbjct: 482 ------ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQM 535
Query: 882 ---DFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYG 937
DF ++ + DG L ++GSG I + NDG W+ V RDG+SG I+V+
Sbjct: 536 IKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT-- 593
Query: 938 ARTG-KSPGMMRQLNINGALYVGGMKE 963
RT +PG L+++ LY+GG+ E
Sbjct: 594 LRTPYTAPGESEILDLDDELYLGGLPE 620
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 126 bits (316), Expect = 1e-28
Identities = 151/690 (21%), Positives = 284/690 (41%), Gaps = 133/690 (19%)
Query: 373 LGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGEN 430
+G G+S ++ I F G Y ++ +N Q+ +ITL F+ +GL+L+ G++
Sbjct: 303 MGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
Query: 431 EHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD-------- 479
D+++LA+ ++ N G+G + E K WH V + R+
Sbjct: 361 ----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG 416
Query: 480 --GLNGL-----LQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQ 532
+N L + ++ TG +Q Y+ + Y+GG+PS L + +N F
Sbjct: 417 HAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNN-FM 475
Query: 533 GCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLC 592
GC++ + + + L K D IHG A K ++ L
Sbjct: 476 GCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VVAFKCENVATLD 520
Query: 593 PLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLL 651
P+ F E+ S+ + P W + +SF FR +G++L
Sbjct: 521 PITF-----------------ETPESFISLPKWNAKKTGSISF-----DFRTTEPNGLIL 558
Query: 652 YSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE-DPLTLGNWHEL 698
+S+ DF +I + GH+ D GSGT +++ + G W+ +
Sbjct: 559 FSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHV 618
Query: 699 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP---- 754
R ++G + V+ + A G + + ++++GG+P + +G++ P
Sbjct: 619 DFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----ENKAGLVFPTEVW 672
Query: 755 -------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCVRAPCAHGGSCR 800
+ G I+ + ++ ++ ++ T+GV + A PC+ PC + G CR
Sbjct: 673 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 732
Query: 801 PRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMR 859
Y CDC G+ G C++ + + G ++ P ++ + +V +R
Sbjct: 733 DGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHTEA---EDVSLR 785
Query: 860 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL---------GSGVASIMVNG 910
F++ G+L+ + R ++D + L L G + + NL G ++
Sbjct: 786 FRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY 842
Query: 911 SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNR 970
+ ND WH V+ VR G+S K+TVDD A TG+ G +L + E + T R
Sbjct: 843 NLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI-------ETGIITER 895
Query: 971 QYMRGL----VGCISHFTLSTDYHISLVED 996
+Y+ + +G + T + +I L ++
Sbjct: 896 RYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 925
Score = 120 bits (301), Expect = 6e-27
Identities = 145/620 (23%), Positives = 245/620 (39%), Gaps = 96/620 (15%)
Query: 346 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 403
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 719 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 774
Query: 404 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 456
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 775 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 834
Query: 457 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 508
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 835 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 894
Query: 509 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 568
YL PS F G +QSL NG A + C +G
Sbjct: 895 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 927
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 628
D I AD P+ FK + A +L++Y +
Sbjct: 928 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 966
Query: 629 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 686
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 967 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 1019
Query: 687 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 743
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 1020 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1077
Query: 744 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 798
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 1078 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1137
Query: 799 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 857
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 1138 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1193
Query: 858 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 916
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 1194 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1251
Query: 917 WHRVKAVRDGQSGKITVDDY 936
+H V+ R G + + VD +
Sbjct: 1252 YHVVRFTRSGGNATLQVDSW 1271
Score = 101 bits (251), Expect = 4e-21
Identities = 91/339 (26%), Positives = 147/339 (43%), Gaps = 22/339 (6%)
Query: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 954 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 1009
Query: 455 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 1010 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1068
Query: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 1069 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1125
Query: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 1126 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1181
Query: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 684
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 1182 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1241
Query: 685 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG 723
S + G +H +R +R+ N LQVD ++E G
Sbjct: 1242 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG 1280
Score = 90.9 bits (224), Expect = 5e-18
Identities = 108/444 (24%), Positives = 164/444 (36%), Gaps = 113/444 (25%)
Query: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 689
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
Query: 690 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 749
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
Query: 750 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 789
LK PF G I+ + +N + VK D + G + A
Sbjct: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
Query: 790 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIE-------------------- 828
C +GG C + CDC GF G C + I ++
Sbjct: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINT 284
Query: 829 -------------------------------IPQFIGRSYLTYD---NPDILKRVSGSRS 854
I F G Y YD NP + S
Sbjct: 285 AKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP-----IQSSSD 339
Query: 855 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIM---VNGS 911
+ + FKT ++GL+L G S +D+++L L++GA+ NLGSG + VNG
Sbjct: 340 EITLSFKTLQRNGLMLHTGKS-----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 394
Query: 912 FNDGRWHRVKAVRDGQ---------------SGKITVDDYGARTGKSPGMMRQLNINGAL 956
FND WH VK R+ + S I+VD TG + L +
Sbjct: 395 FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFF 454
Query: 957 YVGGMKEIALHTNRQYMRGLVGCI 980
YVGG A +GC+
Sbjct: 455 YVGGSPSTADLPGSPVSNNFMGCL 478
Score = 53.9 bits (128), Expect = 7e-07
Identities = 54/221 (24%), Positives = 98/221 (44%), Gaps = 29/221 (13%)
Query: 401 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 457
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
Query: 458 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 516
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
Query: 517 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 561
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
Query: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHC 601
GE G C++GG C+ + D +C C GF+G+ C
Sbjct: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDC 255
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 124 bits (310), Expect = 6e-28
Identities = 139/531 (26%), Positives = 215/531 (40%), Gaps = 82/531 (15%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 406
C +C CVN GG C C G+ E +P S+VTF L+ +
Sbjct: 1407 CANGVCKNGGTCVN-LLIGGFHCVCPPGEYERPYCEVTTRSFPP---QSFVTFRGLRQRF 1462
Query: 407 QAFQITLEFRAEAEDGLLLYCGE-NEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSE-- 463
F I+L F + +GLLLY G NE + DF++L I+ +Q F+ G + +
Sbjct: 1463 H-FTISLTFATQERNGLLLYNGRFNE--KHDFIALEIVDEQVQLTFSAGETTTTVAPKVP 1519
Query: 464 TKIKLGGWHTVML--YRDGLNGLLQLNNG------TPVT------------GQSQGQYS- 502
+ + G WH+V + Y G L L +G VT G+ G YS
Sbjct: 1520 SGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSC 1579
Query: 503 -----------KITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWP 551
+ PL LGG P+ NR F GC+++L+V+G+ +DM +
Sbjct: 1580 AAQGTQTGSKKSLDLTGPLLLGGVPNL--PEDFPVHNRQFVGCMRNLSVDGKNVDMAGF- 1636
Query: 552 LGKALSGADVGECSS--GICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTI 609
A +G G C++ CD C +GGTC + + Y+C CPL F G++CE A
Sbjct: 1637 --IANNGTREG-CAARRNFCDGRRCQNGGTCVN-RWNMYLCECPLRFGGKNCEQAMPHPQ 1692
Query: 610 PQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGG 669
ES+ S++ + YL M FR D VL+ + G F + +
Sbjct: 1693 LFSGESVVSWSDLNIIISVPWYLGLM-----FRTRKEDSVLMEATSGGPTSF-RLQILNN 1746
Query: 670 HVEFRFDCGSG--TGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQ 727
+++F G V+ S +T G WH L + KN + + +V + G Q
Sbjct: 1747 YLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIE--LKNVKEDSEMKHLVTMTLDYGMDQ 1804
Query: 728 IKCNTDIFIGGVPNYDDV-----KKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVE 782
K + + G+ V + V + F G +Q + + +V + +N+
Sbjct: 1805 NKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNV-----ATLNMN 1859
Query: 783 NAA-----------HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 822
NA PC +PC C E Y C C G+ G++C A
Sbjct: 1860 NALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDA 1910
Score = 90.9 bits (224), Expect = 5e-18
Identities = 112/470 (23%), Positives = 195/470 (41%), Gaps = 81/470 (17%)
Query: 563 ECSSGICDEASCIHGGTCTAIKADSYICLCPLG-FKGRHCEDAFTLTIPQFRESLRSYAA 621
+ SG C C +GGTC + + C+CP G ++ +CE PQ + R
Sbjct: 1401 DARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRG--- 1457
Query: 622 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSK-DFLSINLAGGHVEFRFDCGSG 680
L + + + +TF +G+LLY+ K DF+++ + V+ F G
Sbjct: 1458 ----LRQRFHFTI---SLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGET 1510
Query: 681 TGVLRSEDP--LTLGNWHELRVSRTAKNGILQV--------DKQKIV------------- 717
T + + P ++ G WH ++V K I + +K +V
Sbjct: 1511 TTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRF 1570
Query: 718 -----------EGMAEGGFTQIKCNTDIFIGGVPNY-DDVKKNSGVLKPFSGSIQKIILN 765
+G G + + +GGVPN +D ++ + F G ++ + ++
Sbjct: 1571 GKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHN---RQFVGCMRNLSVD 1627
Query: 766 DRTIHVKHDFTSGVNVENAA---HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 822
+ + + + E A + C C +GG+C R Y C+CPL F G +C+
Sbjct: 1628 GKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCE-- 1685
Query: 823 IIEAIEIPQ-FIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 881
+A+ PQ F G S +++ + +I+ V + + F+T +D +L+ P S
Sbjct: 1686 --QAMPHPQLFSGESVVSWSDLNIIISVPW---YLGLMFRTRKEDSVLMEATSG--GPTS 1738
Query: 882 DFISLGLRDGALVFSYNLG-SGVASIMVNG-SFNDGRWH----RVKAVRDGQSGKITVD- 934
L + + L F + G S V S+M++G DG WH +K V++ K V
Sbjct: 1739 --FRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTM 1796
Query: 935 --DYGARTGKSP--GMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 980
DYG K+ GM+ L + ++ VGG E + RG GC+
Sbjct: 1797 TLDYGMDQNKADIGGMLPGLTVR-SVVVGGASEDKVSVR----RGFRGCM 1841
Score = 67.0 bits (162), Expect = 8e-11
Identities = 77/316 (24%), Positives = 126/316 (39%), Gaps = 64/316 (20%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFF-GHSYVTFEPLKNS 405
CD C CVN W C+C L GG++C + + +PQ F G S V++ L
Sbjct: 1653 CDGRRCQNGGTCVN--RWNMYLCECPLRFGGKNCEQ--AMPHPQLFSGESVVSWSDLNII 1708
Query: 406 YQA-FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTG--VAIIVS 462
+ + L FR ED +L+ E G L I+ LQF + G ++++S
Sbjct: 1709 ISVPWYLGLMFRTRKEDSVLM---EATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLS 1765
Query: 463 ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVT---GQSQ------GQYSKITFRTPLYLG 513
++ G WH +++ + ++ + +T G Q G +T R+ + +G
Sbjct: 1766 GLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRS-VVVG 1824
Query: 514 GAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALS-----GADVGE-CSSG 567
GA VR RGF+GC+Q + + G ++ + AL G DV + C+S
Sbjct: 1825 GASEDKVSVR-----RGFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSS 1879
Query: 568 IC----------DEASCI--------------HGGTCTAIKA--------DSYICLCPLG 595
C ++ SC+ H C + A Y+C C
Sbjct: 1880 PCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPS 1939
Query: 596 FKGRHCEDAFTLTIPQ 611
G +CE+ L P+
Sbjct: 1940 HYGPYCENKLDLPCPR 1955
Score = 62.8 bits (151), Expect = 2e-09
Identities = 73/292 (25%), Positives = 115/292 (39%), Gaps = 95/292 (32%)
Query: 788 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIE--------------IPQFI 833
C PC G CR R+ GY C+C F G HC+ ++A + I
Sbjct: 1367 CYSDPCGANGRCRSREGGYTCECFEDFTGEHCE---VDARSGRCANGVCKNGGTCVNLLI 1423
Query: 834 GRSYLT-----YDNP--DILKRVSGSRSNVFMR-------------FKTTAKDGLLLWRG 873
G + Y+ P ++ R +S V R F T ++GLLL+ G
Sbjct: 1424 GGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNG 1483
Query: 874 DSPMRPNSDFISLGLRDGALVFSYNLGSGVASIM--VNGSFNDGRWHRVK---------- 921
DFI+L + D + +++ G ++ V +DGRWH V+
Sbjct: 1484 R--FNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIG 1541
Query: 922 --AVRDGQSGK----ITVDD--------YG--------ARTGKSPGMMRQLNINGALYVG 959
+ G SG+ +TVDD +G A G G + L++ G L +G
Sbjct: 1542 HLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLG 1601
Query: 960 GM----KEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCG 1007
G+ ++ +H NRQ+ VGC+ + +VDGKN++ G
Sbjct: 1602 GVPNLPEDFPVH-NRQF----VGCMRNL-------------SVDGKNVDMAG 1635
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 114 bits (286), Expect = 4e-25
Identities = 141/629 (22%), Positives = 254/629 (40%), Gaps = 118/629 (18%)
Query: 369 CQCT-LGKGGESCSEDIVIQYPQ-------------------FFGHSYVTFEPLKNSYQA 408
C C+ G GG+ CSE+ ++P F G+ + ++ N Q+
Sbjct: 229 CDCSHTGFGGKFCSEE---EHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQS 285
Query: 409 F--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET-- 464
+ITL FR +GL+L+ G++ D+++L++ ++ N G+G + E
Sbjct: 286 STDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVWLVINLGSGAFEALVEPVN 341
Query: 465 -KIKLGGWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGA 515
K WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+
Sbjct: 342 GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGS 401
Query: 516 PSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCI 575
P+ L + +N F GC++ + + L K
Sbjct: 402 PNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELSRLAK--------------------- 439
Query: 576 HGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSF 634
G ++ D L F+ CED L F ES ++ A P W + +S
Sbjct: 440 EGDPKMKLQGD-------LSFR---CEDVAALDPVTF-ESPEAFVALPRWSAKRTGSIS- 487
Query: 635 MEFEITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTG 682
+ FR +G+LL+S GS D+ ++ L GH+ D GSG
Sbjct: 488 ----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGI 543
Query: 683 VLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 741
LR S + G W + R + G + V+ + +A G + +++++GG+P
Sbjct: 544 KLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPE 602
Query: 742 YDDVKK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHP 787
V + + + G ++ + ++ R+ ++ + V V
Sbjct: 603 GGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQ 662
Query: 788 CVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 846
C APC +GG CR + CDC GF G C++ + + G Y+ P+ +
Sbjct: 663 CASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAM 718
Query: 847 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 906
+ +V +RF + GL++ + R ++D + L L G + + NLG G ++
Sbjct: 719 HTEA---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLGKGPETL 772
Query: 907 MVNGSFNDGRWHRVKAVRDGQSGKITVDD 935
ND WH V+ VR G+S +++VD+
Sbjct: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDN 801
Score = 110 bits (274), Expect = 9e-24
Identities = 108/406 (26%), Positives = 171/406 (42%), Gaps = 57/406 (14%)
Query: 636 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 694
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
Query: 695 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 753
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
Query: 754 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 805
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
Query: 806 -YDCDCP-LGFEGLHCQK------------AIIEAIE--IPQFIGRSYLTYD---NPDIL 846
CDC GF G C + E E + F G + YD NP
Sbjct: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNP--- 282
Query: 847 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 906
+ S + + F+T ++GL+L G S +D+++L L+ GA+ NLGSG
Sbjct: 283 --IQSSTDEITLAFRTLQRNGLMLHTGKS-----ADYVNLSLKSGAVWLVINLGSGAFEA 335
Query: 907 M---VNGSFNDGRWHRVKAVRDGQSG--------KITVDDYGARTGKSPGMMRQLNINGA 955
+ VNG FND WH V+ R+ + I+VD TG + L +
Sbjct: 336 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF 395
Query: 956 LYVGGMKEIALHTNRQYMRGLVGCISHFTL-STDYHISLVEDAVDG 1000
Y+GG A +GC+ + D+ + L A +G
Sbjct: 396 FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 441
Score = 108 bits (269), Expect = 3e-23
Identities = 153/651 (23%), Positives = 259/651 (39%), Gaps = 84/651 (12%)
Query: 329 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 385
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 644 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 700
Query: 386 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIR 444
+ + G Y+ P +A ++L F ++ GL++ E D + L +
Sbjct: 701 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESA--DTLRLELDG 756
Query: 445 RSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKI 504
++ N G G + + K+ WHTV + R G + L ++N T V GQ G + ++
Sbjct: 757 GQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQMAGAHMRL 815
Query: 505 TFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC 564
F G + + +N F G + L NG+ P D+ C
Sbjct: 816 EFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCKDGDITYC 864
Query: 565 SSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW 624
E + G AI AD P+ FK R A +L++YA+
Sbjct: 865 ------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQAYAS--- 899
Query: 625 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 684
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G ++
Sbjct: 900 ----------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLM 948
Query: 685 R--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 741
+ S+ P+ WH + VSR N L++D + + + G + +++IGG+
Sbjct: 949 KGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSK 1006
Query: 742 --YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCA 794
+ ++ K F G + + LN R + D + + + C CA
Sbjct: 1007 NMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCA 1066
Query: 795 HGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSR 853
+ G C + +G+ CDC + + G C I G + +TY P R S
Sbjct: 1067 NQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRM 1122
Query: 854 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSF 912
+ + F T + +L+ R DS D++ L + G + +N+G+ +I N
Sbjct: 1123 DRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIV 1180
Query: 913 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 960
+DG++H V+ R G + + VD + G RQL N A+ +GG
Sbjct: 1181 SDGKYHVVRFTRSGGNATLQVDSWPVNERYPAG--RQLTIFNSQAAIKIGG 1229
Score = 102 bits (255), Expect = 1e-21
Identities = 143/603 (23%), Positives = 249/603 (41%), Gaps = 101/603 (16%)
Query: 410 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 468
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
Query: 469 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 528
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
Query: 529 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 585
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
Query: 586 DSYICLCP-LGFKGRHCEDA---------FTLTIPQFRESLRSYAATPW--------PLE 627
C C GF G+ C + TL E + ++ + P++
Sbjct: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQ 284
Query: 628 PQHYLSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINLAGGHVEFRFDCGSGTGVLRS 686
S E + FR +G++L+ TG S D+++++L G V + GSG
Sbjct: 285 S----STDEITLAFRTLQRNGLMLH---TGKSADYVNLSLKSGAVWLVINLGSGAFEALV 337
Query: 687 EDPLTLGN---WHELRVSRTAKN--GI------LQVDKQKIVEGMAEGGFTQIKCNTDIF 735
E N WH++RV+R + GI + VD G + +T + + +
Sbjct: 338 EPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFY 397
Query: 736 IGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAH 795
IGG PN D+ S V F G ++ + ++ +DF ++
Sbjct: 398 IGGSPNTADL-PGSPVSNNFMGCLKDV------VYKNNDFKLELS--------------- 435
Query: 796 GGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAIEIPQFIGRSYLTYDNPD---ILKRVSG 851
R KEG D + +G L + + A++ +T+++P+ L R S
Sbjct: 436 ----RLAKEG---DPKMKLQGDLSFRCEDVAALD--------PVTFESPEAFVALPRWSA 480
Query: 852 SRS-NVFMRFKTTAKDGLLLW---------RGDSPMRPNSDFISLGLRDGALVFSYNLGS 901
R+ ++ + F+TT +GLLL+ G +D+ ++ L DG L ++GS
Sbjct: 481 KRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGS 540
Query: 902 GVASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG 960
G + + NDG W V RDG+ G I+V+ + + G L++ LY+GG
Sbjct: 541 GGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS-RSTPFLATGDSEILDLESELYLGG 599
Query: 961 MKE 963
+ E
Sbjct: 600 LPE 602
Score = 94.7 bits (234), Expect = 4e-19
Identities = 99/384 (25%), Positives = 165/384 (42%), Gaps = 37/384 (9%)
Query: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 887 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 942
Query: 455 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 943 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1001
Query: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 1002 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1058
Query: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 1059 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1114
Query: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 685
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 1115 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1172
Query: 686 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPN 741
++P + G +H +R +R+ N LQVD + E G T I IGG
Sbjct: 1173 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGG--- 1229
Query: 742 YDDVKKNSGVLKPFSGSIQKIILN 765
++ G +PF G + + N
Sbjct: 1230 -----RDQG--RPFQGQVSGLYYN 1246
Score = 92.8 bits (229), Expect = 1e-18
Identities = 97/365 (26%), Positives = 151/365 (41%), Gaps = 44/365 (12%)
Query: 397 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 438
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 464 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 523
Query: 439 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 496
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 524 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 581
Query: 497 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 549
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 582 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRG 641
Query: 550 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 604
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 642 --LAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCERE 698
Query: 605 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 664
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 699 --ATVLSYDGSMYMKIMLPNAMHTEAE----DVSLRFMSQRAYGLMMATTSRESADTLRL 752
Query: 665 NLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGG 724
L GG ++ + G G L + L WH +RV R K+ L VD VEG G
Sbjct: 753 ELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-NVTVEGQMAGA 811
Query: 725 FTQIK 729
+++
Sbjct: 812 HMRLE 816
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 855 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 912
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 901 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 956
Query: 913 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 963
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 957 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1006
Score = 46.2 bits (108), Expect = 2e-04
Identities = 49/205 (23%), Positives = 82/205 (40%), Gaps = 20/205 (9%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 404
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 1060 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1117
Query: 405 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 462
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 1118 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1176
Query: 463 ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ--SQGQYSKITFRTPLYLGGAPSAYW 520
+ G +H V R G N LQ+++ PV + + Q + + + +GG
Sbjct: 1177 NAIVSDGKYHVVRFTRSGGNATLQVDS-WPVNERYPAGRQLTIFNSQAAIKIGGRDQ--- 1232
Query: 521 LVRATGTNRGFQGCVQSLAVNGRRI 545
R FQG V L NG ++
Sbjct: 1233 -------GRPFQGQVSGLYYNGLKV 1250
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 113 bits (282), Expect = 1e-24
Identities = 155/656 (23%), Positives = 258/656 (39%), Gaps = 108/656 (16%)
Query: 340 SRLFDMPCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVT 398
SR+ CD C ++ C + W C CT G G +C + I + G Y+
Sbjct: 267 SRMSAKQCDSYPCKNNAVCKDG--WNRFICDCTGTGYWGRTCEREASIL--SYDGSMYMK 322
Query: 399 F-EPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDFMSLAIIRRSLQFR 450
P+ +A ++ F ++ GLL+ + G + L + ++
Sbjct: 323 IIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRIN 382
Query: 451 FNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-- 508
N G + + K+ WHTV + R G + L +++ G G ++++ F
Sbjct: 383 CNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDV-AEGTMVGDHTRLEFHNIE 441
Query: 509 ------PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRR-IDMRPWPLGKALSGADV 561
Y+ PS+ F G +QSL NG ID+
Sbjct: 442 TGIMTEKRYISVVPSS------------FIGHLQSLMFNGLLYIDL-------------- 475
Query: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAA 621
C +G D I AD P+ FK + S S A
Sbjct: 476 --CKNGDIDYCELKARFGLRNIIAD------PVTFKTK--------------SSYLSLAT 513
Query: 622 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT 681
Q Y S M F+ S DG +L++ G+ DF+++ L G++ + FD G+G
Sbjct: 514 L------QAYTS-MHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGP 565
Query: 682 GVLR--SEDPLTLGNWHELRVSRTAKNG-ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGG 738
V++ S+ PL WH + ++R N L+VD + + + + G + D+++ G
Sbjct: 566 NVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI--NGAKNLDLKGDLYMAG 623
Query: 739 VPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRA 791
+ Y ++ K F G + + LN R + +D SG E + C
Sbjct: 624 LAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQED 683
Query: 792 PCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRS--YLTYDNPDILKR 848
CA+ G C + EG+ CDC + + G C I G+S + Y P R
Sbjct: 684 SCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYI-----FGKSGGLILYTWP-ANDR 737
Query: 849 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMV 908
S + + F TT KDG+L+ +P DF+ L + G + +N+G+ SI
Sbjct: 738 PSTRSDRLAVGFSTTVKDGILVRIDSAP--GLGDFLQLHIEQGKIGVVFNIGTVDISIKE 795
Query: 909 NGS-FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 960
+ NDG++H V+ R+G + + VD++ G RQL N + +GG
Sbjct: 796 ERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTG--RQLTIFNTQAQIAIGG 849
Score = 87.0 bits (214), Expect = 8e-17
Identities = 102/467 (21%), Positives = 189/467 (40%), Gaps = 96/467 (20%)
Query: 511 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 570
Y+GG+PS L + +N F GC++ + I + L + I D
Sbjct: 9 YVGGSPSTADLPGSPVSNN-FMGCLKEVVYKNNDIRLELSRLAR-------------IAD 54
Query: 571 EASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQ 629
I+G K ++ L P+ F E+ +Y + P W +
Sbjct: 55 TKMKIYGEV--VFKCENVATLDPINF-----------------ETPEAYISLPKWNTKRM 95
Query: 630 HYLSFMEFEITFRPDSGDGVLLYSY-------DTGSK-----DFLSINLAGGHVEFRFDC 677
+SF FR +G++L+++ D S+ DF ++ L G++ D
Sbjct: 96 GSISF-----DFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDM 150
Query: 678 GSGT-GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFI 736
GSGT V ++ G W+ + + R ++G + V+ ++ A G + D+++
Sbjct: 151 GSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRR-TPFTASGESEILDLEGDMYL 209
Query: 737 GGVPNYDDVKKNSGVLKP-----------FSGSIQKIILNDRTIHVKH--DFTSGVNVEN 783
GG+P + +G++ P + G I+ + ++ R+ +++ + + V++
Sbjct: 210 GGLP-----ENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKS 264
Query: 784 A-----AHPCVRAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSY 837
+ A C PC + C+ + CDC G+ G C++ I + G Y
Sbjct: 265 SCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREA----SILSYDGSMY 320
Query: 838 LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSY 897
+ P ++ + +V RF + GLL+ + R ++D + L L G +
Sbjct: 321 MKIIMPMVMHTEA---EDVSFRFMSQRAYGLLV---ATTSRDSADTLRLELDGGRVKLMV 374
Query: 898 NL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 935
NL G ++ ND WH V+ VR G+S K+TVDD
Sbjct: 375 NLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
Score = 85.9 bits (211), Expect = 2e-16
Identities = 96/396 (24%), Positives = 168/396 (42%), Gaps = 46/396 (11%)
Query: 401 PLKNSYQAFQITLEFRAEAEDGLLLY----------CGENEHGRGDFMSLAIIRRSLQFR 450
P N+ + I+ +FR +GL+L+ ++ + DF ++ ++ +L
Sbjct: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLL 147
Query: 451 FNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQSQGQYSKITFRT 508
+ G+G + + ++ K G W+ V + RDG +G + +N+ TP T + G+ +
Sbjct: 148 LDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT--ASGESEILDLEG 205
Query: 509 PLYLGGAP-SAYWLVRATG-----TNRGFQGCVQSLAVNGRRIDMRPWPLGKALSG--AD 560
+YLGG P + L+ T N G+ GC++ L ++GR ++R + +G +
Sbjct: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSS 265
Query: 561 VGECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCEDAFTLTIPQFRESLRSY 619
S+ CD C + C + +IC C G+ GR CE +I + S+
Sbjct: 266 CSRMSAKQCDSYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCER--EASILSYDGSMYMK 322
Query: 620 AATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE------- 672
P + + + F G+L+ + S D L + L GG V+
Sbjct: 323 IIMPMVM----HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDC 378
Query: 673 FRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKC 730
R +C S G L + L WH +RV R K+ L VD + EG G T+++
Sbjct: 379 IRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD-DDVAEGTMVGDHTRLEF 437
Query: 731 -NTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 765
N + I Y V +S F G +Q ++ N
Sbjct: 438 HNIETGIMTEKRYISVVPSS-----FIGHLQSLMFN 468
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 110 bits (276), Expect = 5e-24
Identities = 128/530 (24%), Positives = 210/530 (39%), Gaps = 100/530 (18%)
Query: 369 CQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPL--KNSYQAFQITLEFRAEAEDGLLLY 426
C C G G+ C + F SY+ F L N+Y I ++F LLLY
Sbjct: 3962 CHCPFGVFGKHCE----LNSYGFEELSYMEFPSLDPNNNY----IYVKFATIKSHALLLY 4013
Query: 427 CGENEHG-RGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLL 485
+N+ G R +F++L I L+F +N G+G + + K+ G +HTV+ R G+ L
Sbjct: 4014 NYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHFHTVIARRAGMAASL 4073
Query: 486 QLNNGTPVTGQSQGQYSKITFR---------TPLYLGGAPSAYWLVRATG--TNRGFQGC 534
+++ + S + + +GG S +++ G + F GC
Sbjct: 4074 TVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGC 4133
Query: 535 VQSLAVNGRRIDMRPWPLGKALSGADVGECS--SGICDEASCIHGGTCTAIKADSYICLC 592
+ AVNGR ++ P + + +C G C + C HGGTC + C C
Sbjct: 4134 IMEFAVNGRPLE----PSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSWQQ-CHC 4188
Query: 593 PLGFKGRHCEDAFT----------------LTIPQFRESLRSYAATPWPLEPQHYLSFME 636
G G++CE + T ++ + RE L + LEP
Sbjct: 4189 KEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEP---FGVNS 4245
Query: 637 FEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRS--EDPLTLGN 694
E+ FR S +GVL++ + S ++ ++ + G V F D G V R+ E + G+
Sbjct: 4246 LEVKFRTRSENGVLIHIQE--SSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGH 4303
Query: 695 WHELRVSRTAKNGILQVDK---QKIVEGMAEGGFTQIKCNTDIFIGGVP----------- 740
WH + + +L VD+ + I+ + G + I +GG+P
Sbjct: 4304 WHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDV---LTISLGGIPPNQAHRDAQTA 4360
Query: 741 NYDDVKKN---SGVLKPFSG--SIQKIILNDRTIHVKHDFTSGVNVENAAHP-------- 787
+D + G PFSG S+ I D ++ + G N+ A++P
Sbjct: 4361 GFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIG---CRGPNI-CASNPCWGDLLCI 4416
Query: 788 -------------CVRAPCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAI 823
C PC +GGSC P G+ C CP G C+ +
Sbjct: 4417 NQWYAYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVV 4466
Score = 109 bits (272), Expect = 1e-23
Identities = 116/492 (23%), Positives = 207/492 (42%), Gaps = 62/492 (12%)
Query: 529 RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGE-CSSGI--CDEASCIHGGTCTAIKA 585
R C+QS NG P G+ C S + C+ C +GG+C +
Sbjct: 3899 RDINECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQS-GV 3957
Query: 586 DSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDS 645
DSY C CP G G+HCE L F E SY P L+P + +++F
Sbjct: 3958 DSYYCHCPFGVFGKHCE----LNSYGFEEL--SYMEFP-SLDPNNNYIYVKFATI----K 4006
Query: 646 GDGVLLYSYD--TGSK-DFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSR 702
+LLY+YD TG + +FL++ +A + F ++ GSGT L + ++ G++H + R
Sbjct: 4007 SHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHFHTVIARR 4066
Query: 703 TAKNGILQVDKQKIVEGMAEGGFTQIKCNTD---------IFIGGVPNYDDVKKNSGVLK 753
L VD + + + + D + +GG+ + + + + G ++
Sbjct: 4067 AGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVE 4126
Query: 754 P--FSGSIQKIILNDRTIHVKHDFTSGVNVENAAH---PCVRAPCAHGGSCRPRKEGYDC 808
F G I + +N R + + ++ C R+PC HGG+C C
Sbjct: 4127 SHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSWQQC 4186
Query: 809 DCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR-------VSGSRSNVF---- 857
C G G +C+K++ + G+ L Y KR + G+ F
Sbjct: 4187 HCKEGLTGKYCEKSVTPDTAL-SLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNS 4245
Query: 858 --MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFN 913
++F+T +++G+L+ ++ +S++ ++ +++G + F+ + G V +
Sbjct: 4246 LEVKFRTRSENGVLI-----HIQESSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVA 4300
Query: 914 DGRWHRVKAVRDGQSGKITVDDYGARTGKSP----GMMRQLNINGALYVGGMKEIALHTN 969
DG WH ++G + ++VD R P G + L I+ +GG+ H +
Sbjct: 4301 DGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTIS----LGGIPPNQAHRD 4356
Query: 970 RQYMRGLVGCIS 981
Q G GCI+
Sbjct: 4357 AQ-TAGFDGCIA 4367
Score = 89.0 bits (219), Expect = 2e-17
Identities = 72/277 (25%), Positives = 114/277 (41%), Gaps = 41/277 (14%)
Query: 724 GFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN 783
GFT C DI KN + + F GS + T G E+
Sbjct: 3891 GFTGRACERDIN----ECLQSPCKNGAICQNFPGSFNCVCKTGYT---------GKMCES 3937
Query: 784 AAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 843
+ + C PC +GGSC+ + Y C CP G G HC+ + F SY+ + +
Sbjct: 3938 SVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE------LNSYGFEELSYMEFPSL 3991
Query: 844 DILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV 903
D + + ++++F T LLL+ D+ ++F++L + + L FSYNLGSG
Sbjct: 3992 D------PNNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGT 4045
Query: 904 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNI----------- 952
+ +DG +H V A R G + +TVD + PG N+
Sbjct: 4046 YKLTTMKKVSDGHFHTVIARRAGMAASLTVD--SCSENQEPGYCTVSNVAVSDDWTLDVQ 4103
Query: 953 NGALYVGGMKEIALHTNRQ---YMRGLVGCISHFTLS 986
+ VGG++ + R+ VGCI F ++
Sbjct: 4104 PNRVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVN 4140
Score = 50.1 bits (118), Expect = 1e-05
Identities = 63/330 (19%), Positives = 113/330 (34%), Gaps = 66/330 (20%)
Query: 327 PIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIV- 385
P Q G+ + C + C C++ ++W +C C G G+ C + +
Sbjct: 4146 PSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSW--QQCHCKEGLTGKYCEKSVTP 4203
Query: 386 -------------IQYPQFFGHSYVTFEPLKNS----YQAFQITLEFRAEAEDGLLLYCG 428
Q Y+ + L+ + + + ++FR +E+G+L++
Sbjct: 4204 DTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQ 4263
Query: 429 ENEHGRGDFMSLAIIRRSLQFRFNCGTG--VAIIVSETKIKLGGWHTVMLYRDGLNGLLQ 486
E+ ++ ++ I + F + G V + E + G WHT ++ ++G +L
Sbjct: 4264 ES----SNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLS 4319
Query: 487 L----NNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNG 542
+ N Q G +T + LGG P GF GC+ S+ G
Sbjct: 4320 VDRIYNRDIIHPTQDFGGLDVLT----ISLGGIPPNQ--AHRDAQTAGFDGCIASMWYGG 4373
Query: 543 RRIDMRPWPLGKALSGADVGE---------CSS---------------------GICDEA 572
+ ++S D C+S G C
Sbjct: 4374 ESLPFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYRCVPPGDCASH 4433
Query: 573 SCIHGGTCTAIKADSYICLCPLGFKGRHCE 602
C +GG+C + C CP GR CE
Sbjct: 4434 PCQNGGSCEPGLHSGFTCSCPDSHTGRTCE 4463
Score = 45.1 bits (105), Expect = 3e-04
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 788 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 830
C+ +PC GG+C G+ C CP GF G C++ I E ++ P
Sbjct: 3866 CLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSP 3908
Score = 35.8 bits (81), Expect = 0.21
Identities = 45/174 (25%), Positives = 66/174 (37%), Gaps = 46/174 (26%)
Query: 682 GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP- 740
GV +D LT H LR++ + G+ G A ++ + N F+
Sbjct: 3718 GVPTVKDFLTNHYLHFLRIASSQLTGL----------GTAVQLYSAYEENNRTFLLAAVK 3767
Query: 741 -NYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHP-CVRAPCAHGGS 798
N++ SGV F SI++I+L SGV VE+ H CV PC +GGS
Sbjct: 3768 RNHNQYVNPSGVATFFE-SIKEILLRQ----------SGVKVESVDHDSCVHGPCQNGGS 3816
Query: 799 CRPR----------------------KEGYDCDCPLGFEGLHCQKAIIEAIEIP 830
C R + + C C G+ G C+ I E + P
Sbjct: 3817 CLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPSP 3870
Score = 33.9 bits (76), Expect = 0.79
Identities = 21/53 (39%), Positives = 24/53 (45%), Gaps = 3/53 (5%)
Query: 552 LGKALSGADVGECSSGI--CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 602
L K L G C I C + C GGTC + + C CP GF GR CE
Sbjct: 3847 LCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNL-VGGFSCSCPDGFTGRACE 3898
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 105 bits (263), Expect = 2e-22
Identities = 131/610 (21%), Positives = 244/610 (40%), Gaps = 119/610 (19%)
Query: 410 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLG 469
QI + F + +GLLLY G +G DF+S+ + R ++ + G+G ++++ + G
Sbjct: 2328 QIIMLFNTFSPNGLLLYLGS--YGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNG 2385
Query: 470 GWHTVMLYRDGLNGLLQL------NNGTPVTGQSQGQYSKITF--RTPLYLGGAPSAYWL 521
W+ + R+ G+L + +N G++ G S + + P+Y+GG P + +
Sbjct: 2386 TWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSR-V 2444
Query: 522 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 581
VR T + F GC+++L ++ D+ + + G
Sbjct: 2445 VRRGVTTKSFVGCIKNLEISRSTFDL--------------------LRNSYGVRKGCLLE 2484
Query: 582 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITF 641
I++ S++ KG + E L P+ E+ +TF
Sbjct: 2485 PIRSVSFL-------KGGYIE-----------------------LPPKSLSPESEWLVTF 2514
Query: 642 RPDSGDGVLLYSYD-----TGSKD-----FLSINLAGGHVEFRFDCGSGTGVLRS----- 686
+ G++L + G ++ F S+ L GG++E + G GTG+ ++
Sbjct: 2515 ATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAP 2574
Query: 687 EDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCN--TDIFIGGVPNYDD 744
+ G H + + R + +Q+D+ VE M G + + +++++GG+P +
Sbjct: 2575 TGTCSDGQAHSISLVRNRRIITVQLDENNPVE-MKLGTLVESRTINVSNLYVGGIPEGEG 2633
Query: 745 VKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENA-------AHPCVRAPCAHGG 797
+ + + F G I+ +I N + DF S V E + AP A
Sbjct: 2634 TSLLT-MRRSFHGCIKNLIFNLELL----DFNSAVGHEQVDLDTCWLSERPKLAPDAEDS 2688
Query: 798 SCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSY-----LTYDNPDILKRVSGS 852
P + C + A +E + G + L ++ + K++S
Sbjct: 2689 KLLPEPRAFPEQCVVD--------AALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLS-- 2738
Query: 853 RSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSF 912
V + +T A GL+ + + +D+ L L G L F ++LG G +
Sbjct: 2739 ---VELSIRTFASSGLIYYMAH---QNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALL 2792
Query: 913 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQY 972
+DG+WH VK + G ITVD + G L++ G Y+GG+ QY
Sbjct: 2793 SDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPS-------QY 2845
Query: 973 MRGLVGCISH 982
+G I+H
Sbjct: 2846 QARKIGNITH 2855
Score = 85.1 bits (209), Expect = 3e-16
Identities = 88/393 (22%), Positives = 160/393 (40%), Gaps = 71/393 (18%)
Query: 613 RESLRSYAATPWPLEPQ-HYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHV 671
R+ +R+Y +PQ ++ + + D +L Y + + DFL++ + G V
Sbjct: 2124 RDCIRAY-------QPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRV 2176
Query: 672 EFRFDCGSGTGVLRSED-PLTLGNWHELRVSRTAKNGILQVDKQ--------KIVEGMAE 722
F +D GSG+ L D P+ WH + V+R G L V + K +
Sbjct: 2177 AFLWDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGT 2236
Query: 723 GGFTQIKCNTDIFIGGVPNYDDVKKNSGV-LKPFSGSIQKIILNDRTIHVKHDFTSGVNV 781
+ +T +F+GG+ +KK+ V + F G + + LN ++I + + +
Sbjct: 2237 ANVLDVNNSTLMFVGGLGG--QIKKSPAVKVTHFKGCLGEAFLNGKSIGL----WNYIER 2290
Query: 782 ENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYD 841
E C GS + + D G Y +
Sbjct: 2291 EGKCRGCF-------GSSQNEDPSFHFD------------------------GSGYSVVE 2319
Query: 842 NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS 901
K + + + + M F T + +GLLL+ G + DF+S+ L G + +LGS
Sbjct: 2320 -----KSLPATVTQIIMLFNTFSPNGLLLYLGSYGTK---DFLSIELFRGRVKVMTDLGS 2371
Query: 902 GVASIMVNGSFNDGRWHRVKAVRDGQSGKITV-DDYG-----ARTGKSPGMMRQLN--IN 953
G +++ + +N+G W+++ R+ + G + V D Y + G++PG LN
Sbjct: 2372 GPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDK 2431
Query: 954 GALYVGGMKEIALHTNRQYMRGLVGCISHFTLS 986
+YVGG+ + + VGCI + +S
Sbjct: 2432 DPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEIS 2464
Score = 80.9 bits (198), Expect = 6e-15
Identities = 113/546 (20%), Positives = 196/546 (35%), Gaps = 73/546 (13%)
Query: 428 GENEHGRGDFMSLAIIRRSLQFRFNCGTGV----AIIVSETKIKLGGW-HTVMLYRDGLN 482
G+ E F S+ +I +++ N G G A++ + T G H++ L R+
Sbjct: 2535 GDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRI 2594
Query: 483 GLLQLNNGTPVTGQSQGQYSKITFRTP-LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVN 541
+QL+ PV + T LY+GG P T R F GC+++L N
Sbjct: 2595 ITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLT-MRRSFHGCIKNLIFN 2653
Query: 542 GRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHC 601
+D A+ V + + + DS + P F +
Sbjct: 2654 LELLDFN-----SAVGHEQVDLDTCWLSERPKLAPDAE------DSKLLPEPRAFPEQCV 2702
Query: 602 EDAFTLTIP---QFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS 658
DA +P QF + S+ P+ + E++ R + G++ Y
Sbjct: 2703 VDAALEYVPGAHQFGLTQNSHFILPF--NQSAVRKKLSVELSIRTFASSGLIYYMAHQNQ 2760
Query: 659 KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE 718
D+ + L GG + F FD G G + L+ G WH ++ + G + VD ++
Sbjct: 2761 ADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPM 2820
Query: 719 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 778
G T + ++GG+P+ +K + I + +N + + K S
Sbjct: 2821 VTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQLD-KDSPVSA 2879
Query: 779 VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 838
V N + + GS GY L EG Q +
Sbjct: 2880 FTV-NRCYAVAQEGTYFDGS------GY---AALVKEGYKVQSDV--------------- 2914
Query: 839 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 898
N+ + F+T++++G+LL + + D I L L DG ++F N
Sbjct: 2915 ----------------NITLEFRTSSQNGVLLGISTAKV----DAIGLELVDGKVLFHVN 2954
Query: 899 LGSGVASIMVNGS----FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNING 954
G+G + DG+WH ++A + + VD ++ N
Sbjct: 2955 NGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTNN 3014
Query: 955 ALYVGG 960
+YVGG
Sbjct: 3015 PIYVGG 3020
Score = 77.8 bits (190), Expect = 5e-14
Identities = 139/641 (21%), Positives = 238/641 (37%), Gaps = 130/641 (20%)
Query: 399 FEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTG-V 457
++P +S +TL + + D LL Y G + DF+++ + R + F ++ G+G
Sbjct: 2130 YQPQISSTNYNTLTLNVKTQEPDNLLFYLGSST--ASDFLAVEMRRGRVAFLWDLGSGST 2187
Query: 458 AIIVSETKIKLGGWHTVMLYRDGLNGLLQL-----NNGTPV-TGQSQGQYS--KITFRTP 509
+ + I WH++ + R G G L + N +P T +S G + + T
Sbjct: 2188 RLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTL 2247
Query: 510 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGIC 569
+++GG A F+GC+ +NG+ I + W + I
Sbjct: 2248 MFVGGLGGQIKKSPAVKVTH-FKGCLGEAFLNGKSIGL--W---------------NYIE 2289
Query: 570 DEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQ 629
E C R C + P F Y+ L
Sbjct: 2290 REGKC------------------------RGCFGSSQNEDPSFHFDGSGYSVVEKSLPAT 2325
Query: 630 HYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP 689
M F TF P +G+LLY G+KDFLSI L G V+ D GSG L ++
Sbjct: 2326 VTQIIMLFN-TFSP---NGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRR 2381
Query: 690 LTLGNWHELRVSRTAKNGILQV------DKQKIVEGMAEGGFTQI-KCNTD-IFIGGVPN 741
G W+++ R K G+L V ++ +G G + + + + D I++GG+P
Sbjct: 2382 YNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPR 2441
Query: 742 YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRP 801
V + K F G I+ + ++ T + + VR C
Sbjct: 2442 -SRVVRRGVTTKSFVGCIKNLEISRSTFDLLRNSYG-----------VRKGC-------- 2481
Query: 802 RKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFK 861
++E I F+ Y+ ++ + S + F
Sbjct: 2482 ---------------------LLEPIRSVSFLKGGYI-----ELPPKSLSPESEWLVTFA 2515
Query: 862 TTAKDGLLL--WRGDSPMRPNSD-----FISLGLRDGALVFSYNLGSGVASIMV-----N 909
TT G++L GD R + + F S+ L G + N G G
Sbjct: 2516 TTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPT 2575
Query: 910 GSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNIN-GALYVGGMKEIALHT 968
G+ +DG+ H + VR+ + + +D+ K ++ IN LYVGG+ E +
Sbjct: 2576 GTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTS 2635
Query: 969 NRQYMRGLVGCISHFTLS---TDYHISLVEDAVDGKNINTC 1006
R GCI + + D++ ++ + VD ++TC
Sbjct: 2636 LLTMRRSFHGCIKNLIFNLELLDFNSAVGHEQVD---LDTC 2673
Score = 64.7 bits (156), Expect = 4e-10
Identities = 71/335 (21%), Positives = 114/335 (34%), Gaps = 56/335 (16%)
Query: 411 ITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 470
+ L R A GL+ Y + D+ L + L F F+ G G + + G
Sbjct: 2739 VELSIRTFASSGLIYYMAHQN--QADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGK 2796
Query: 471 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRG 530
WHTV G + ++ G + + YLGG PS Y +
Sbjct: 2797 WHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHS 2856
Query: 531 FQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYIC 590
C+ + VN +++D +S V C + + E + G Y
Sbjct: 2857 IPACIGDVTVNSKQLDK-----DSPVSAFTVNRCYA-VAQEGTYFDG--------SGYAA 2902
Query: 591 LCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVL 650
L G+K + S + + FR S +GVL
Sbjct: 2903 LVKEGYKVQ---------------------------------SDVNITLEFRTSSQNGVL 2929
Query: 651 LYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL-----GNWHELRVSRTAK 705
L T D + + L G V F + G+G + + +P T G WH L+ +++
Sbjct: 2930 L-GISTAKVDAIGLELVDGKVLFHVNNGAGR-ITAAYEPKTATVLCDGKWHTLQANKSKH 2987
Query: 706 NGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP 740
L VD + T + N I++GG P
Sbjct: 2988 RITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYP 3022
Score = 45.1 bits (105), Expect = 3e-04
Identities = 38/157 (24%), Positives = 64/157 (40%), Gaps = 13/157 (8%)
Query: 391 FFGHSYVTFEPLKNSYQA---FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSL 447
F G Y +K Y+ ITLEFR +++G+LL + D + L ++ +
Sbjct: 2895 FDGSGYAAL--VKEGYKVQSDVNITLEFRTSSQNGVLLGIST---AKVDAIGLELVDGKV 2949
Query: 448 QFRFNCGTGVAIIVSETKIKL----GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSK 503
F N G G E K G WHT+ + L ++ Q +
Sbjct: 2950 LFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTS 3009
Query: 504 ITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAV 540
+ P+Y+GG P+ + + F+GC++ LA+
Sbjct: 3010 VDTNNPIYVGGYPAGV-KQKCLRSQTSFRGCLRKLAL 3045
Score = 32.3 bits (72), Expect = 2.3
Identities = 29/107 (27%), Positives = 37/107 (34%), Gaps = 28/107 (26%)
Query: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAA 621
G C C+ +HG C C+C LG G C++
Sbjct: 1504 GSCQKCDCNPHGSVHGD-CDRTSGQ---CVCRLGASGLRCDEC----------------- 1542
Query: 622 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAG 668
EP+H L ME + D GVLL D LS+NL G
Sbjct: 1543 -----EPRHIL--METDCVSCDDECVGVLLNDLDEIGDAVLSLNLTG 1582
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 101 bits (251), Expect = 4e-21
Identities = 129/533 (24%), Positives = 199/533 (37%), Gaps = 80/533 (15%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 406
C +C C D GG RCQC G E ++ + F S+V F L+ +
Sbjct: 1479 CVPGVCRNGGTCT-DAPNGGFRCQCPAGGAFEGPRCEVAAR--SFPPSSFVMFRGLRQRF 1535
Query: 407 QAFQITLEFRAEAEDGLLLYCGE-NEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 465
++L F + GLL Y G NE + DF++L ++ ++ ++ G ++
Sbjct: 1536 H-LTLSLSFATVQQSGLLFYNGRLNE--KHDFLALELVAGQVRLTYSTGESNTVVSPTVP 1592
Query: 466 IKL--GGWHTVMLY------RDGLNGL---------------------LQL-----NNGT 491
L G WHTV L D L G LQ N
Sbjct: 1593 GGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSC 1652
Query: 492 PVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWP 551
G + PL LGG P+ +++ F GC++ L ++GRR+DM +
Sbjct: 1653 AAAGVQTSSKKSLDLTGPLLLGGVPNLP--ENFPVSHKDFIGCMRDLHIDGRRVDMAAFV 1710
Query: 552 LGKALSGADVG-ECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 610
A +G G + CD C + G C+ + S+ C CP+GF G+ C+ T+ P
Sbjct: 1711 ---ANNGTMAGCQAKLHFCDSGPCKNSGFCSE-RWGSFSCDCPVGFGGKDCQ--LTMAHP 1764
Query: 611 QFRESLRSYAATPWPLEPQHYLSFMEF-EITFRPDSGDGVLLYSYDTGSKDFLSINLAGG 669
R W +S + + FR + GVL+ G L L G
Sbjct: 1765 HH---FRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLM-QVQAGPHSTLLCQLDRG 1820
Query: 670 HVEFRFDCGSGTGVLRSEDPLTL--GNWHELRVSRTAKNG--------ILQVDKQKIVEG 719
+ GSG D +T+ G WH+LR+ + G ++ +D +
Sbjct: 1821 LLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDT 1880
Query: 720 MAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRT------IHVKH 773
MA G Q + +GG+P + G++ G IQ + L + H
Sbjct: 1881 MAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLV----GCIQGVWLGSTPSGSPALLPPSH 1936
Query: 774 DFTS--GVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAII 824
+ G V NA C PC CR + + C C G+ G C A +
Sbjct: 1937 RVNAEPGCVVTNA---CASGPCPPHADCRDLWQTFSCTCQPGYYGPGCVDACL 1986
Score = 87.8 bits (216), Expect = 5e-17
Identities = 115/469 (24%), Positives = 183/469 (39%), Gaps = 76/469 (16%)
Query: 563 ECSSGICDEASCIHGGTCTAIKADSYICLCPLG--FKGRHCEDAFTLTIPQFRESLRSYA 620
+ +G C C +GGTCT + C CP G F+G CE A P R
Sbjct: 1473 DTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRG-- 1530
Query: 621 ATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSK-DFLSINLAGGHVEFRFDCGS 679
L + +L+ ++F G+L Y+ K DFL++ L G V + G
Sbjct: 1531 -----LRQRFHLTL---SLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGE 1582
Query: 680 GTGVLRSEDP--LTLGNWHELRVS-----RTAKNG-----------ILQVDKQKIVEGM- 720
V+ P L+ G WH + + RT G +L VD + +
Sbjct: 1583 SNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQ 1642
Query: 721 -----------AEGGFTQIKCNTDI----FIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 765
A G T K + D+ +GGVPN + S K F G ++ + ++
Sbjct: 1643 FGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSH--KDFIGCMRDLHID 1700
Query: 766 DRTIHVKHDFTSG---VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 822
R + + + + H C PC + G C R + CDCP+GF G CQ
Sbjct: 1701 GRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLT 1760
Query: 823 IIEAIEIPQFIGRSYLTYD-NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 881
+ F G L+++ D+ V + + F+T A G+L+ P+S
Sbjct: 1761 MAHP---HHFRGNGTLSWNFGSDMAVSVPW---YLGLAFRTRATQGVLM---QVQAGPHS 1811
Query: 882 DFISLGLRDGALVFSYNLGSGVAS--IMVNGSFNDGRWHRVKAVRDGQSG--------KI 931
+ L G L + GSG AS ++ + +DGRWH ++ + G +
Sbjct: 1812 TLL-CQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMV 1870
Query: 932 TVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 980
++D + + G Q L+VGG+ + + +GLVGCI
Sbjct: 1871 SLDFSLFQDTMAVGSELQGLKVKQLHVGGLPP---GSAEEAPQGLVGCI 1916
Score = 54.3 bits (129), Expect = 6e-07
Identities = 44/149 (29%), Positives = 63/149 (42%), Gaps = 26/149 (17%)
Query: 781 VENAAHPCVRAPCAHGGSCRPRKE-GYDCDCPLG--FEGLHCQKAIIEAIEIPQFIGRSY 837
++ A CV C +GG+C G+ C CP G FEG C+ A RS+
Sbjct: 1472 LDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVA-----------ARSF 1520
Query: 838 LTYDNPDILKRVSGSRS----NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGAL 893
P G R + + F T + GLL + G + DF++L L G +
Sbjct: 1521 ----PPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNG--RLNEKHDFLALELVAGQV 1574
Query: 894 VFSYNLGSG--VASIMVNGSFNDGRWHRV 920
+Y+ G V S V G +DG+WH V
Sbjct: 1575 RLTYSTGESNTVVSPTVPGGLSDGQWHTV 1603
Score = 50.1 bits (118), Expect = 1e-05
Identities = 68/294 (23%), Positives = 103/294 (35%), Gaps = 33/294 (11%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFF---GHSYVTFEPLK 403
CD C FC WG C C +G GG+ C + + +P F G F
Sbjct: 1726 CDSGPCKNSGFCSE--RWGSFSCDCPVGFGGKDC--QLTMAHPHHFRGNGTLSWNFGSDM 1781
Query: 404 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVA--IIV 461
+ + L FR A G+L+ H + + R L G+G A +++
Sbjct: 1782 AVSVPWYLGLAFRTRATQGVLMQVQAGPHST---LLCQLDRGLLSVTVTRGSGRASHLLL 1838
Query: 462 SETKIKLGGWHTVMLY-------RDGLNGLL-----QLNNGTPVTGQSQGQYSKITFRTP 509
+ + G WH + L R G + L+ L T G S+ Q K+
Sbjct: 1839 DQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVG-SELQGLKV---KQ 1894
Query: 510 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGIC 569
L++GG P A +G GC+Q + + A+ G + C
Sbjct: 1895 LHVGGLPPG----SAEEAPQGLVGCIQGVWLGSTPSGSPALLPPSHRVNAEPGCVVTNAC 1950
Query: 570 DEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP 623
C C + ++ C C G+ G C DA L Q + S R P
Sbjct: 1951 ASGPCPPHADCRDL-WQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPGAP 2003
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 100 bits (248), Expect = 9e-21
Identities = 81/285 (28%), Positives = 127/285 (44%), Gaps = 36/285 (12%)
Query: 346 PCDETLCSADSFCVNDYTWGGSR----CQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEP 401
PC E C D CV+ + SR CQC GK GE CS + F G+SY+ +
Sbjct: 3798 PCVEKPCPGDMQCVS---YEASRRPFLCQCPPGKLGE-CSGHTSLS---FAGNSYIKYRL 3850
Query: 402 LKNSYQA-FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAII 460
+NS + F++ L R +G+++Y N + L I+ L F+ +CG+G I+
Sbjct: 3851 SENSKEEDFKLALRLRTLQSNGIIMYTRANP-----CIILKIVDGKLWFQLDCGSGPGIL 3905
Query: 461 -VSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAY 519
+S + G WH+V L + L L++ ++ + ++ + +Y G A
Sbjct: 3906 GISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQAD 3965
Query: 520 WL-----VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADV---GECSSGI--- 568
+ R T GFQGC+ S+ +N + ++ K S A+V E G
Sbjct: 3966 NIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQ----NKRSSFAEVVGLTELKLGCVLY 4021
Query: 569 ---CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 610
C + C HGG+CT + + Y C C F GR+CE T P
Sbjct: 4022 PDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFP 4066
Score = 79.3 bits (194), Expect = 2e-14
Identities = 67/293 (22%), Positives = 115/293 (39%), Gaps = 37/293 (12%)
Query: 564 CSSGICD-------EASCIHGGTCTAIKADS--YICLCPLGFKGRHCEDAFTLTIPQFRE 614
C+ G+C E C C + +A ++C CP G G C +L
Sbjct: 3787 CNGGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGE-CSGHTSL------- 3838
Query: 615 SLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFR 674
S + + L + + R +G+++Y T + + + + G + F+
Sbjct: 3839 SFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMY---TRANPCIILKIVDGKLWFQ 3895
Query: 675 FDCGSGTGVLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTD 733
DCGSG G+L S + G+WH + + L +D + A F + +
Sbjct: 3896 LDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESS 3955
Query: 734 IFIGGVPNYDDVK-----KNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH-- 786
I+ G + D+++ + + VL F G + +ILN+ + +++ +S V
Sbjct: 3956 IYFGALVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELK 4015
Query: 787 --------PCVRAPCAHGGSCRPRKE-GYDCDCPLGFEGLHCQKAIIEAIEIP 830
C R+PC HGGSC GY C C F G +C+ I P
Sbjct: 4016 LGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNP 4068
Score = 57.0 bits (136), Expect = 9e-08
Identities = 50/212 (23%), Positives = 87/212 (41%), Gaps = 25/212 (11%)
Query: 787 PCVRAPCAHGGSC---RPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 843
PCV PC C + + C CP G G + F G SY+ Y
Sbjct: 3798 PCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLS------FAGNSYIKYRLS 3851
Query: 844 DILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV 903
+ K + +R +T +G++++ +P I L + DG L F + GSG
Sbjct: 3852 ENSKEED---FKLALRLRTLQSNGIIMYTRANPC------IILKIVDGKLWFQLDCGSGP 3902
Query: 904 ASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMK 962
+ ++G + NDG WH V + +++DD ++P + L+ ++Y G +
Sbjct: 3903 GILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALV 3962
Query: 963 EI----ALHTNR--QYMRGLVGCISHFTLSTD 988
+ +L R Q + G GC+ L+ +
Sbjct: 3963 QADNIRSLTDTRVTQVLSGFQGCLDSVILNNN 3994
Score = 35.4 bits (80), Expect = 0.27
Identities = 19/63 (30%), Positives = 30/63 (47%), Gaps = 4/63 (6%)
Query: 777 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQF-IGR 835
+GV E + C R C +GGSC + C+C G+ G +C + + +P G
Sbjct: 4091 TGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCG---LRPVVVPNIQAGH 4147
Query: 836 SYL 838
SY+
Sbjct: 4148 SYV 4150
Score = 31.6 bits (70), Expect = 3.9
Identities = 11/33 (33%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHC 601
C+ C +GG+C + S++C C G+ G++C
Sbjct: 4102 CEREECENGGSCVNVFG-SFLCNCTPGYVGQYC 4133
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 99.8 bits (247), Expect = 1e-20
Identities = 132/603 (21%), Positives = 240/603 (39%), Gaps = 111/603 (18%)
Query: 391 FFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 448
F G+ + ++ N Q+ +ITL FR +GL+L+ G++ D+++L++ ++
Sbjct: 292 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVW 347
Query: 449 FRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD----------GLNGL-----LQLNNG 490
N G+G + E K WH V + R+ +N L + ++
Sbjct: 348 LVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGI 407
Query: 491 TPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPW 550
TG +Q Y+ + Y+GG+P+ L + +N F GC++ + +
Sbjct: 408 LTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELS 466
Query: 551 PLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 610
L K G ++ D L F+ CED L
Sbjct: 467 RLAK---------------------EGDPKMKLQGD-------LSFR---CEDVAALDPV 495
Query: 611 QFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLLYSYD------TGSK---- 659
F ES ++ A P W + +S + FR +G+LL+S GS
Sbjct: 496 TF-ESPEAFVALPRWSAKRTGSIS-----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQ 549
Query: 660 --DFLSINLAGGHVEFRFDCGSGTGVLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKI 716
D+ ++ L GH+ D GSG LR S + G W + R + G + V+ +
Sbjct: 550 RADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS- 608
Query: 717 VEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-------NSGVLKPFSGSIQKIILNDRTI 769
+A G + +++++GG+P V + + + G ++ + ++ R+
Sbjct: 609 TPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSR 668
Query: 770 HVKH--DFTSGVNV-----ENAAHPCVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQK 821
++ + V V C APC +GG CR + CDC GF G C++
Sbjct: 669 DLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER 728
Query: 822 AIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 881
+ + G Y+ P+ + + +V +RF + GL++ + R ++
Sbjct: 729 EAT----VLSYDGSMYMKIMLPNAMHTEA---EDVSLRFMSQRAYGLMM---ATTSRESA 778
Query: 882 DFISLGLRDGALVFSYNL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 932
D + L L G + + NL G ++ ND WH V+ VR G+S +++
Sbjct: 779 DTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLS 838
Query: 933 VDD 935
VD+
Sbjct: 839 VDN 841
Score = 98.2 bits (243), Expect = 3e-20
Identities = 107/437 (24%), Positives = 170/437 (38%), Gaps = 88/437 (20%)
Query: 636 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 694
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
Query: 695 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 753
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
Query: 754 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 805
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
Query: 806 -YDCDCP-LGFEGLHC--------------------------------------QKAIIE 825
CDC GF G C Q +
Sbjct: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGK 285
Query: 826 AIEIPQFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSD 882
+ F G + YD NP + S + + F+T ++GL+L G S +D
Sbjct: 286 EEFVATFKGNEFFCYDLSHNP-----IQSSTDEITLAFRTLQRNGLMLHTGKS-----AD 335
Query: 883 FISLGLRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRDGQSG---------- 929
+++L L+ GA+ NLGSG + VNG FND WH V+ R+ +
Sbjct: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
Query: 930 -----KITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFT 984
I+VD TG + L + Y+GG A +GC+
Sbjct: 396 LHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 455
Query: 985 L-STDYHISLVEDAVDG 1000
+ D+ + L A +G
Sbjct: 456 YKNNDFKLELSRLAKEG 472
Score = 97.4 bits (241), Expect = 6e-20
Identities = 145/631 (22%), Positives = 247/631 (39%), Gaps = 84/631 (13%)
Query: 329 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 385
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 675 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 731
Query: 386 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDF 437
+ + G Y+ P +A ++L F ++ GL++ E G
Sbjct: 732 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQ 789
Query: 438 MSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQS 497
M L + L+ G + + K+ WHTV + R G + L ++N T V GQ
Sbjct: 790 MKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQM 848
Query: 498 QGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALS 557
G + ++ F G + + +N F G + L NG+ P
Sbjct: 849 AGAHMRLEFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCK 897
Query: 558 GADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLR 617
D+ C E + G AI AD P+ FK R A +L+
Sbjct: 898 DGDITYC------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQ 935
Query: 618 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 677
+YA+ M F+ + DG+LL++ G+ DF+ I L G++ + FD
Sbjct: 936 AYAS-------------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDL 981
Query: 678 GSGTGVLR--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDI 734
G+G +++ S+ P+ WH + VSR N L++D + + + G + ++
Sbjct: 982 GNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGEL 1039
Query: 735 FIGGVPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHP 787
+IGG+ + ++ K F G + + LN R + D + + +
Sbjct: 1040 YIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTT 1099
Query: 788 CVRAPCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 846
C CA+ G C + +G+ CDC + + G C I G + +TY P
Sbjct: 1100 CTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-N 1155
Query: 847 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 906
R S + + F T + +L+ R DS D++ L + G + +N+G+ +I
Sbjct: 1156 DRPSTRMDRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITI 1213
Query: 907 -MVNGSFNDGRWHRVKAVRDGQSGKITVDDY 936
N +DG++H V+ R G + + VD +
Sbjct: 1214 DEPNAIVSDGKYHVVRFTRSGGNATLQVDSW 1244
Score = 94.4 bits (233), Expect = 5e-19
Identities = 90/343 (26%), Positives = 151/343 (44%), Gaps = 26/343 (7%)
Query: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 927 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 982
Query: 455 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 983 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1041
Query: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 1042 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1098
Query: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 1099 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1154
Query: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 685
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 1155 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1212
Query: 686 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGF 725
++P + G +H +R +R+ N LQVD + E G F
Sbjct: 1213 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
Score = 90.9 bits (224), Expect = 5e-18
Identities = 146/630 (23%), Positives = 249/630 (39%), Gaps = 124/630 (19%)
Query: 410 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 468
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
Query: 469 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 528
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
Query: 529 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 585
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
Query: 586 DSYICLCP-LGFKGRHCEDA---------FTLT--------------------IPQFRES 615
C C GF G+ C + TL + Q +
Sbjct: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKG 284
Query: 616 LRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINL 666
+ AT E Y S E + FR +G++L+ TG S D+++++L
Sbjct: 285 KEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH---TGKSADYVNLSL 341
Query: 667 AGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAKN--GI------------- 708
G V + GSG E N WH++RV+R + GI
Sbjct: 342 KSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVT 401
Query: 709 LQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRT 768
+ VD G + +T + + +IGG PN D+ S V F G ++ +
Sbjct: 402 ISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADL-PGSPVSNNFMGCLKDV------ 454
Query: 769 IHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAI 827
++ +DF ++ R KEG D + +G L + + A+
Sbjct: 455 VYKNNDFKLELS-------------------RLAKEG---DPKMKLQGDLSFRCEDVAAL 492
Query: 828 EIPQFIGRSYLTYDNPD---ILKRVSGSRS-NVFMRFKTTAKDGLLLW---------RGD 874
+ +T+++P+ L R S R+ ++ + F+TT +GLLL+ G
Sbjct: 493 D--------PVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGS 544
Query: 875 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG-SFNDGRWHRVKAVRDGQSGKITV 933
+D+ ++ L DG L ++GSG + + NDG W V RDG+ G I+V
Sbjct: 545 HSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISV 604
Query: 934 DDYGARTGKSPGMMRQLNINGALYVGGMKE 963
+ + + G L++ LY+GG+ E
Sbjct: 605 NS-RSTPFLATGDSEILDLESELYLGGLPE 633
Score = 85.5 bits (210), Expect = 2e-16
Identities = 100/375 (26%), Positives = 153/375 (40%), Gaps = 55/375 (14%)
Query: 397 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 438
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 495 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 554
Query: 439 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 496
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 555 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 612
Query: 497 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 549
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 613 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLR- 671
Query: 550 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 604
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 672 -GLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCER- 728
Query: 605 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 664
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 729 -EATVLSYDGSMYMKIMLPNAM----HTEAEDVSLRFMSQRAYGLMMATTSRESADTLRL 783
Query: 665 NLAGGHVEF--RFDCGSGTGVLRSEDPLTL--------GNWHELRVSRTAKNGILQVDKQ 714
L GG ++ DC G S+ P TL WH +RV R K+ L VD
Sbjct: 784 ELDGGQMKLTVNLDC-LRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-N 841
Query: 715 KIVEGMAEGGFTQIK 729
VEG G +++
Sbjct: 842 VTVEGQMAGAHMRLE 856
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 855 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 912
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 941 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 996
Query: 913 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 963
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1046
Score = 45.1 bits (105), Expect = 3e-04
Identities = 52/224 (23%), Positives = 84/224 (37%), Gaps = 28/224 (12%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 404
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 1100 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1157
Query: 405 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 462
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 1158 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1216
Query: 463 ETKIKLGGWHTVMLYRDGLNGLLQ-----LNNGTPVTGQSQGQYSKITFRTPLYLGGAPS 517
+ G +H V R G N LQ +N P + + R P LG
Sbjct: 1217 NAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVD 1276
Query: 518 AYWL--------------VRATGTNRG--FQGCVQSLAVNGRRI 545
+ L ++ G ++G FQG V L NG ++
Sbjct: 1277 EWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
Score = 43.9 bits (102), Expect = 8e-04
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 850 SGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV-ASIMV 908
+ S + +T A LLL+ D + DF+ L L DG L + L A++ +
Sbjct: 47 AASSGELSFSLRTNATRALLLYLDDGG---DCDFLELLLVDGRLRLRFTLSCAEPATLQL 103
Query: 909 NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 961
+ D RWH V RD + + VD AR + R++ + L+VGG+
Sbjct: 104 DTPVADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGI 155
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 92.4 bits (228), Expect = 2e-18
Identities = 82/306 (26%), Positives = 133/306 (43%), Gaps = 55/306 (17%)
Query: 346 PCDETLCSADSFCVNDYTWGGSR--CQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLK 403
PC+ T C + CV+ G+R CQC G GG C + + + + +Y+ F L+
Sbjct: 1130 PCEGTECQNGANCVDQ----GNRPVCQCLPGFGGPECEKLLSVNFVD--RDTYLQFTDLQ 1183
Query: 404 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT--GVAIIV 461
N +A ITL+ ++G+LLY G+N+H +++ + + ++ ++ G+ AI
Sbjct: 1184 NWPRA-NITLQVSTAEDNGILLYNGDNDH-----IAVELYQGHVRVSYDPGSYPSSAIYS 1237
Query: 462 SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP----S 517
+ET I G +HTV L L ++ G+P+T + G++ + PLY+GG P S
Sbjct: 1238 AET-INDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNS 1296
Query: 518 AYWLVRATGTNRGFQGCVQSLAVNGRRIDMR----------------------------- 548
A + + GF GC+++L +N D
Sbjct: 1297 AAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNA 1356
Query: 549 -PWPLGKALSGADVGEC---SSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDA 604
P P+ +G C + G C C+HG C + A SY C C G+ G C A
Sbjct: 1357 TPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQDGYSGALCNQA 1415
Query: 605 FTLTIP 610
L P
Sbjct: 1416 GALAEP 1421
Score = 68.6 bits (166), Expect = 3e-11
Identities = 51/177 (28%), Positives = 84/177 (47%), Gaps = 18/177 (10%)
Query: 787 PCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR-SYLTYDNPDI 845
PC C +G +C + C C GF G C+K + F+ R +YL + +
Sbjct: 1130 PCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSV-----NFVDRDTYLQFTDLQ- 1183
Query: 846 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 905
+ R+N+ ++ T +G+LL+ GD+ D I++ L G + SY+ GS +S
Sbjct: 1184 ----NWPRANITLQVSTAEDNGILLYNGDN------DHIAVELYQGHVRVSYDPGSYPSS 1233
Query: 906 IMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 961
+ + + NDG++H V+ V Q +++D T + G LN LYVGGM
Sbjct: 1234 AIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGM 1290
Score = 67.4 bits (163), Expect = 6e-11
Identities = 63/266 (23%), Positives = 107/266 (40%), Gaps = 34/266 (12%)
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 628
C+ C +G C + + +C C GF G CE ++ L+ WP
Sbjct: 1131 CEGTECQNGANCVD-QGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPR-- 1187
Query: 629 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVLRSE 687
+ + +++ D+G +LLY+ G D +++ L GHV +D GS + + S
Sbjct: 1188 ----ANITLQVSTAEDNG--ILLYN---GDNDHIAVELYQGHVRVSYDPGSYPSSAIYSA 1238
Query: 688 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 747
+ + G +H + + + L +D + G + +++GG+P V
Sbjct: 1239 ETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMP----VDV 1294
Query: 748 NSGVLK--------PFSGSIQKIILNDRTIHVKHDFTSGV---NVENAAHPCVRAPCAHG 796
NS + F G I+ + +N+ DFT V PC + C HG
Sbjct: 1295 NSAAFRLWQILNGTGFHGCIRNLYINNEL----QDFTKTQMKPGVVPGCEPCRKLYCLHG 1350
Query: 797 GSCRPRKE-GYDCDCPLGFEGLHCQK 821
C+P G C C G+ GLHC +
Sbjct: 1351 -ICQPNATPGPMCHCEAGWVGLHCDQ 1375
Score = 41.6 bits (96), Expect = 0.004
Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 4/48 (8%)
Query: 776 TSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 823
T GVN ++ CV CA+GG C Y C CPL +EG C++ +
Sbjct: 1001 TCGVNTDD----CVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
Score = 39.7 bits (91), Expect = 0.014
Identities = 32/133 (24%), Positives = 54/133 (40%), Gaps = 10/133 (7%)
Query: 480 GLNGLLQLN-NGTPVTGQSQGQYSKITFRTPLYLGGAP-----SAYWL---VRATGTNRG 530
GL L L+ +G ++ +G ++ +T + L +G P WL V+ G
Sbjct: 830 GLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPG 889
Query: 531 FQGCVQSLAVNGRRIDMRPWPLGKALSGADVG-ECSSGICDEASCIHGGTCTAIKADSYI 589
C + G+ + P + + + +C + C + GTC + Y
Sbjct: 890 IARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYR 949
Query: 590 CLCPLGFKGRHCE 602
C CP G+KGR CE
Sbjct: 950 CACPSGYKGRDCE 962
Score = 37.7 bits (86), Expect = 0.055
Identities = 19/46 (41%), Positives = 24/46 (52%), Gaps = 5/46 (10%)
Query: 778 GVNVENAAHPCVRAPCAHGGSCRPRKEGYD----CDCPLGFEGLHC 819
G + E + C PC +GG+C + EG D C CP GFEG C
Sbjct: 958 GRDCEVSLDSCSSGPCENGGTCHAQ-EGEDAPFTCSCPTGFEGPTC 1002
Score = 35.8 bits (81), Expect = 0.21
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 2/41 (4%)
Query: 563 ECSSGICDEASCIHGGTCTAIKADS--YICLCPLGFKGRHC 601
E S C C +GGTC A + + + C CP GF+G C
Sbjct: 962 EVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
Score = 35.8 bits (81), Expect = 0.21
Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 1/42 (2%)
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 610
C + +C +GG C +Y C CPL ++G+ CE L P
Sbjct: 1009 CVDHACANGGVCVD-GVGNYTCQCPLQYEGKACEQLVDLCSP 1049
Score = 33.9 bits (76), Expect = 0.79
Identities = 13/37 (35%), Positives = 22/37 (59%), Gaps = 1/37 (2%)
Query: 788 CVRAPCAHGGSCRPRK-EGYDCDCPLGFEGLHCQKAI 823
C+ +PC + G+C E Y C CP G++G C+ ++
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
Score = 31.6 bits (70), Expect = 3.9
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 9/59 (15%)
Query: 327 PIQRKGKNGVAIMSRLFDMPCDETL--CSADSFCVNDYTWGGSRCQCTLGKGGESCSED 383
P+Q +GK +L D+ C L C ++ CV T G RC+C G G++CSE+
Sbjct: 1032 PLQYEGK----ACEQLVDL-CSPDLNPCQHEAQCVG--TPDGPRCECMPGYAGDNCSEN 1083
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 88.6 bits (218), Expect = 3e-17
Identities = 71/274 (25%), Positives = 114/274 (41%), Gaps = 35/274 (12%)
Query: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 406
C++ C S CV+D C C G+ G+ + G+SYV + +N
Sbjct: 3794 CEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMT----LTGNSYVKYRLTENEN 3849
Query: 407 QA-FQITLEFRAEAEDGLLLYCGENEHGRG-DFMSLAIIRRSLQFRFNCGTGVAII-VSE 463
+ ++T+ R + +++Y RG D+ L I LQ++F+CG+G I+ V
Sbjct: 3850 KLEMKLTMRLRTYSTHAVVMYA------RGTDYSILEIHHGRLQYKFDCGSGPGIVSVQS 3903
Query: 464 TKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVR 523
++ G WH V L +G L L+ +G + G + ++ GG +R
Sbjct: 3904 IQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGH------IR 3957
Query: 524 ATGTNRG--------FQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI------- 568
GT G F+GC+ S+ +NG+ + + P A V + S G
Sbjct: 3958 QQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESV-DVSPGCFLTATED 4016
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 602
C C +GG C A Y C C + G HCE
Sbjct: 4017 CASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCE 4050
Score = 83.2 bits (204), Expect = 1e-15
Identities = 65/271 (23%), Positives = 115/271 (42%), Gaps = 27/271 (9%)
Query: 569 CDEASCIHGGTCTAIK-ADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLE 627
C++ C G C + + + C+CP G G+ C + ++T+ S Y T E
Sbjct: 3794 CEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ-CPGSSSMTLTG--NSYVKYRLT----E 3846
Query: 628 PQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSE 687
++ L M+ + R S V++Y+ T D+ + + G ++++FDCGSG G++ +
Sbjct: 3847 NENKLE-MKLTMRLRTYSTHAVVMYARGT---DYSILEIHHGRLQYKFDCGSGPGIVSVQ 3902
Query: 688 D-PLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVK 746
+ G WH + + L +D+ G A G + + +F GG +
Sbjct: 3903 SIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTR 3962
Query: 747 --KNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVE-----------NAAHPCVRAPC 793
++ V F G + I LN + + + S ++E A C PC
Sbjct: 3963 HGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPC 4022
Query: 794 AHGGSCRPRKE-GYDCDCPLGFEGLHCQKAI 823
+GG C P GY C C + G HC+ ++
Sbjct: 4023 QNGGVCNPSPAGGYYCKCSALYIGTHCEISV 4053
Score = 65.9 bits (159), Expect = 2e-10
Identities = 52/208 (25%), Positives = 92/208 (44%), Gaps = 23/208 (11%)
Query: 786 HPCVRAPCAHGGSC--RPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 843
H C PC G C P +E + C CP G G C + + G SY+ Y
Sbjct: 3792 HGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFG-QCPGSSSMTLT-----GNSYVKYR-- 3843
Query: 844 DILKRVSGSRSNVFMRFKTTAKDGLLLW-RGDSPMRPNSDFISLGLRDGALVFSYNLGSG 902
+ + + + MR +T + ++++ RG +D+ L + G L + ++ GSG
Sbjct: 3844 -LTENENKLEMKLTMRLRTYSTHAVVMYARG-------TDYSILEIHHGRLQYKFDCGSG 3895
Query: 903 VASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG- 960
+ V NDG+WH V +G ++ +D +G +PG ++ LN++ ++ GG
Sbjct: 3896 PGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGH 3955
Query: 961 MKEIALHTNR--QYMRGLVGCISHFTLS 986
+++ R Q G GC+ L+
Sbjct: 3956 IRQQGTRHGRSPQVGNGFRGCMDSIYLN 3983
Score = 42.7 bits (99), Expect = 0.002
Identities = 23/66 (34%), Positives = 30/66 (45%), Gaps = 16/66 (24%)
Query: 559 ADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRS 618
+D+ ECS C+HG C SY C C ++GRHCEDA +
Sbjct: 4126 SDIDECSGN-----PCLHGALCENTHG-SYHCNCSHEYRGRHCEDA----------APNQ 4169
Query: 619 YAATPW 624
Y +TPW
Sbjct: 4170 YVSTPW 4175
Score = 37.7 bits (86), Expect = 0.055
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 788 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIE 825
C PC +GG+C +G C C GF G CQ I E
Sbjct: 4093 CKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDE 4130
Score = 36.2 bits (82), Expect = 0.16
Identities = 14/45 (31%), Positives = 19/45 (42%)
Query: 778 GVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 822
G ++ C PC HG C Y C+C + G HC+ A
Sbjct: 4121 GERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDA 4165
Score = 33.9 bits (76), Expect = 0.79
Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 566 SGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 602
S C + C +GGTC D +C C GF+G C+
Sbjct: 4090 SPYCKDEPCKNGGTCFD-SLDGAVCQCDSGFRGERCQ 4125
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo
sapiens]
Length = 1331
Score = 87.8 bits (216), Expect = 5e-17
Identities = 106/433 (24%), Positives = 180/433 (41%), Gaps = 66/433 (15%)
Query: 411 ITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTG-VAIIVSETKIKLG 469
I L F+ +G++L+ GE + +GD+++L + + L N G+ + I T + G
Sbjct: 212 IALNFKTSESEGVILH-GEGQ--QGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTG 268
Query: 470 G------WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVR 523
WH+V++ R G + L L+ ++ G++ + + GG P +
Sbjct: 269 SLLDDHHWHSVVIERQGRSINLTLDRSMQHF-RTNGEFDYLDLDYEITFGGIPFSG--KP 325
Query: 524 ATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTA- 582
++ + + F+GC++S+ NG +++ K L ++VG S SC+ T
Sbjct: 326 SSSSRKNFKGCMESINYNG--VNITDLARRKKLEPSNVGNLS------FSCVEPYTVPVF 377
Query: 583 IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFR 642
A SY L GR +D F+++ QFR W P L F F
Sbjct: 378 FNATSY-----LEVPGRLNQDLFSVSF-QFR---------TW--NPNGLLVFSHF----- 415
Query: 643 PDSGDGVLLYSYD-TGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVS 701
D + D T SK + IN+ + + D SG+G L G WHE+R
Sbjct: 416 ---ADNLGNVEIDLTESKVGVHINITQTKMS-QIDISSGSG-------LNDGQWHEVRFL 464
Query: 702 RTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQK 761
IL +D + + Q+K F GG N + +S + F G +Q
Sbjct: 465 AKENFAILTIDGDE-ASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQL 523
Query: 762 IILNDRTIHV------KHDFTSGVNVENAA--HPCVRAPCAHGGSCRPRKEGYDCDC-PL 812
I ++D+ +++ K + V+++ A CV C HGG C + + C C
Sbjct: 524 IQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDET 583
Query: 813 GFEGLHCQKAIIE 825
G+ G C +I E
Sbjct: 584 GYSGATCHNSIYE 596
Score = 80.9 bits (198), Expect = 6e-15
Identities = 99/396 (25%), Positives = 163/396 (41%), Gaps = 63/396 (15%)
Query: 628 PQHYLSFMEFE--------ITFRPDSGDGVLLYSYDTGSKDFLSINLAGG-HVEFRFDCG 678
P YL F F+ F+ + GV L + G +DF+ + L V F FD G
Sbjct: 806 PSSYLHFSTFQGETSADISFYFKTLTPWGVFLENM--GKEDFIKLELKSATEVSFSFDVG 863
Query: 679 SGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDK--QKIVEGMAEGGFTQIKCNTDI 734
+G V+RS PL WH + R K LQVD+ Q+I + EG T+++ + +
Sbjct: 864 NGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEG-HTRLELYSQL 922
Query: 735 FIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNVENAAHPCVR-- 790
F+GG +G + F G I+ + +N T+ ++ TSG + + C
Sbjct: 923 FVGG----------AGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGF-ISGCSGHCTSYG 971
Query: 791 APCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRV 849
C +GG C R GY CDC ++G C K + E ++ + P R
Sbjct: 972 TNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWL---RYNFQAPATNARD 1028
Query: 850 SGSR----------------SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLR-DGA 892
S SR + F TT +LL+ +DF+++ ++ G+
Sbjct: 1029 SSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSF----TTDFLAVLVKPTGS 1084
Query: 893 LVFSYNLGSGVASIMV---NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQ 949
L YNLG + + + +G+ H V R ++ + +D Y + + P
Sbjct: 1085 LQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDT 1144
Query: 950 L-NINGALYVGGMKE---IALHTNRQYMRGLVGCIS 981
L N +L++G + E I ++ G GC+S
Sbjct: 1145 LFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLS 1180
Score = 52.4 bits (124), Expect = 2e-06
Identities = 81/344 (23%), Positives = 136/344 (39%), Gaps = 48/344 (13%)
Query: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS-LQFRFNC 453
SY+ F + A I+ F+ G+ L G+ DF+ L + + + F F+
Sbjct: 808 SYLHFSTFQGETSA-DISFYFKTLTPWGVFL----ENMGKEDFIKLELKSATEVSFSFDV 862
Query: 454 GTGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQ-YSKITFRTPL 510
G G IV S T + WH V R+ LQ++ ++ + ++++ + L
Sbjct: 863 GNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQL 922
Query: 511 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 570
++GGA G +GF GC++SL +NG +D+ K SG G SG C
Sbjct: 923 FVGGA----------GGQQGFLGCIRSLRMNGVTLDLE--ERAKVTSGFISG--CSGHCT 968
Query: 571 E--ASCIHGGTCTAIKADSYICLCP-LGFKGRHCED--------------AFTLTIPQFR 613
+C +GG C + Y C C + G C F R
Sbjct: 969 SYGTNCENGGKCLE-RYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNAR 1027
Query: 614 ESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINL-AGGHVE 672
+S P L+ E +F +LLY + + DFL++ + G ++
Sbjct: 1028 DSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLY-ISSFTTDFLAVLVKPTGSLQ 1086
Query: 673 FRFDCGSGTGVLRSED----PLTLGNWHELRVSRTAKNGILQVD 712
R++ G GT + D + G H + ++R K L++D
Sbjct: 1087 IRYNLG-GTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLD 1129
Score = 47.8 bits (112), Expect = 5e-05
Identities = 30/95 (31%), Positives = 48/95 (50%), Gaps = 11/95 (11%)
Query: 847 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS----- 901
K++ + + + FKT+ +G++L G+ D+I+L L+ LV S NLGS
Sbjct: 203 KKMKTLKDVIALNFKTSESEGVIL-HGEGQQ---GDYITLELKKAKLVLSLNLGSNQLGP 258
Query: 902 --GVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 934
G S+M +D WH V R G+S +T+D
Sbjct: 259 IYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLD 293
Score = 42.7 bits (99), Expect = 0.002
Identities = 62/307 (20%), Positives = 116/307 (37%), Gaps = 56/307 (18%)
Query: 639 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT-GVLRSEDPLTLGN--- 694
+ F+ +GV+L+ + D++++ L + + GS G + + G+
Sbjct: 214 LNFKTSESEGVILHG-EGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLD 272
Query: 695 ---WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 751
WH + + R ++ L +D+ + G F + + +I GG+P K +S
Sbjct: 273 DHHWHSVVIERQGRSINLTLDRS-MQHFRTNGEFDYLDLDYEITFGGIPFSG--KPSSSS 329
Query: 752 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 811
K F G ++ I N GVN+ + A P G + C
Sbjct: 330 RKNFKGCMESINYN------------GVNITDLARRKKLEPSNVGNL------SFSC--- 368
Query: 812 LGFEGLHCQKAIIEAIEIPQFIGR-SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLL 870
+E +P F SYL ++ R++ +V +F+T +GLL+
Sbjct: 369 ------------VEPYTVPVFFNATSYL-----EVPGRLNQDLFSVSFQFRTWNPNGLLV 411
Query: 871 WRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS---IMVNGSFNDGRWHRVKAVRDGQ 927
+ S N + + L + + N+ S I NDG+WH V+ +
Sbjct: 412 F---SHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKEN 468
Query: 928 SGKITVD 934
+T+D
Sbjct: 469 FAILTID 475
Score = 39.3 bits (90), Expect = 0.019
Identities = 52/241 (21%), Positives = 92/241 (38%), Gaps = 29/241 (12%)
Query: 379 SCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFM 438
SC E + P FF + P + + F ++ +FR +GLL++ H +
Sbjct: 367 SCVEPYTV--PVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVF----SHFADNLG 420
Query: 439 SLAIIRRSLQFRFNCGTGVAIIVSETKIKL-----------GGWHTVMLYRDGLNGLLQL 487
++ I + GV I +++TK+ G WH V +L +
Sbjct: 421 NVEIDLTESK------VGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTI 474
Query: 488 NNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM 547
+G + ++ + GG + + FQGC+Q + V+ + +++
Sbjct: 475 -DGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNL 533
Query: 548 RPWPLGKALSGADVGECSSGICDEA---SCIHGGTCTAIKADSYICLC-PLGFKGRHCED 603
K S A+V I D C HGG C+ DS+ C C G+ G C +
Sbjct: 534 YEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQ-TWDSFKCTCDETGYSGATCHN 592
Query: 604 A 604
+
Sbjct: 593 S 593
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 87.4 bits (215), Expect = 6e-17
Identities = 88/334 (26%), Positives = 142/334 (42%), Gaps = 47/334 (14%)
Query: 631 YLSFMEFEITFRPDSG--------DGVLLYSYDTGSKDFLSINLAG-GHVEFRFDCGSGT 681
YL F F F D GV L + G KDF+ + ++ + F D G+G
Sbjct: 801 YLHFPTFHAEFSADISFFFKTTALSGVFLENL--GIKDFIRLEISSPSEITFAIDVGNGP 858
Query: 682 GVLRSEDPLTLGN--WHELRVSRTAKNGILQVDK-QKIVEGMAEGGFTQIKCNTDIFIGG 738
L + P L + WH +R R K LQVD + +E G +++ N+ +F+GG
Sbjct: 859 VELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVGG 918
Query: 739 VPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNVENAAH-PCVRAPCAH 795
S K F G I+ + LN + + ++ TSGV H + C +
Sbjct: 919 T---------SSRQKGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHN 969
Query: 796 GGSCRPRKEGYDCDCPLG-FEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVS---- 850
GG C + GY CDC +EG C+K + E + +Y+ + + K +S
Sbjct: 970 GGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSV--TYMFQEPYPVTKNISLSSS 1027
Query: 851 -------GSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSG 902
S+ N+ + F TT LLL+ S + DF+ + L ++G+L Y+L
Sbjct: 1028 AIYTDSAPSKENIALSFVTTQAPSLLLFINSS----SQDFVVVLLCKNGSLQVRYHLNKE 1083
Query: 903 VASIMV--NGSFNDGRWHRVKAVRDGQSGKITVD 934
+ +F + R H +K R+G+ I +D
Sbjct: 1084 ETHVFTIDADNFANRRMHHLKINREGRELTIQMD 1117
Score = 60.5 bits (145), Expect = 8e-09
Identities = 78/339 (23%), Positives = 140/339 (41%), Gaps = 38/339 (11%)
Query: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS-LQFRFNC 453
SY+ F + A I+ F+ A G+ L G DF+ L I S + F +
Sbjct: 800 SYLHFPTFHAEFSA-DISFFFKTTALSGVFL----ENLGIKDFIRLEISSPSEITFAIDV 854
Query: 454 GTGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQ-SQGQYSKITFRTPL 510
G G +V ++ L WH V R+ LQ++N T + S+ + ++ + L
Sbjct: 855 GNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQL 914
Query: 511 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 570
++GG S +GF GC++SL +NG+++D+ K SG G C
Sbjct: 915 FVGGTSSR---------QKGFLGCIRSLHLNGQKMDLE--ERAKVTSGVRPG-CPGHCSS 962
Query: 571 EASCIHGGTCTAIKADSYICLCPLG-FKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQ 629
S H G K + Y+C C ++G C+ + + + S+ P+P+
Sbjct: 963 YGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVS-AVFEAGTSVTYMFQEPYPVTKN 1021
Query: 630 HYLSFM-----------EFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFDC 677
LS ++F +LL+ ++ S+DF+ + L G ++ R+
Sbjct: 1022 ISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLF-INSSSQDFVVVLLCKNGSLQVRYHL 1080
Query: 678 GSGTGVLRSEDPLTLGN--WHELRVSRTAKNGILQVDKQ 714
+ + D N H L+++R + +Q+D+Q
Sbjct: 1081 NKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQQ 1119
Score = 53.9 bits (128), Expect = 7e-07
Identities = 78/330 (23%), Positives = 120/330 (36%), Gaps = 52/330 (15%)
Query: 639 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP-LTLGN--- 694
+ F+ GDGVL + + D +++ L G + + G L S P TLG+
Sbjct: 207 LKFKSMQGDGVLFHG-EGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLGSLLD 265
Query: 695 ---WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 751
WH + + R K VDK +G + + ++ GG+P K + +
Sbjct: 266 DQHWHSVLIERVGKQVNFTVDKHT-QHFRTKGETDALDIDYELSFGGIPVPG--KPGTFL 322
Query: 752 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 811
K F G I+ + N GVN+ + A R + + Y
Sbjct: 323 KKNFHGCIENLYYN------------GVNIIDLAK-------------RRKHQIYT---- 353
Query: 812 LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLW 871
G C + I I G L P I +V +F+T KDGLLL
Sbjct: 354 -GNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQI------DGLSVSFQFRTWNKDGLLL- 405
Query: 872 RGDSPMRPNSDFISLGLRDGAL-VFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGK 930
+ + S + L L G L + + VA I+ + NDG WH V
Sbjct: 406 --STELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWHSVSINARRNRIT 463
Query: 931 ITVDDYGARTGKSPGMMRQLNINGALYVGG 960
+T+DD A + Q+ + Y GG
Sbjct: 464 LTLDDEAAPPAPDSTWV-QIYSGNSYYFGG 492
Score = 52.0 bits (123), Expect = 3e-06
Identities = 87/433 (20%), Positives = 159/433 (36%), Gaps = 67/433 (15%)
Query: 411 ITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 470
I+L+F++ DG+L + GE + RGD ++L + + L N G A + S G
Sbjct: 205 ISLKFKSMQGDGVLFH-GEGQ--RGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLG 261
Query: 471 -------WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVR 523
WH+V++ R G ++ T +++G+ + L GG P
Sbjct: 262 SLLDDQHWHSVLIERVGKQVNFTVDKHTQHF-RTKGETDALDIDYELSFGGIPVPG--KP 318
Query: 524 ATGTNRGFQGCVQSLAVNG-RRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTA 582
T + F GC+++L NG ID+ + +G CS + ++
Sbjct: 319 GTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYTGNVTFSCSEPQIVPITFVN------ 372
Query: 583 IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFR 642
+ SY+ L P PQ + + FR
Sbjct: 373 -SSGSYLLL---------------------------------PGTPQ--IDGLSVSFQFR 396
Query: 643 PDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFD-CGSGTGVLRSEDPLTLGNWHELRVS 701
+ DG+LL + + L ++L GG + + + L G WH + ++
Sbjct: 397 TWNKDGLLLSTELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWHSVSIN 456
Query: 702 RTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQK 761
L +D + + + QI + GG P+ + +K F G ++
Sbjct: 457 ARRNRITLTLD-DEAAPPAPDSTWVQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRL 515
Query: 762 IILNDR---TIHVKHDFTSG-----VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDC-PL 812
I ++++ I V+ +++ + C+ C HGGSC + C+C
Sbjct: 516 IFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDT 575
Query: 813 GFEGLHCQKAIIE 825
+ G C +I E
Sbjct: 576 SYTGATCHNSIYE 588
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 19/132 (14%)
Query: 860 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGA-LVFSYNLGSGVASIMVNGS--FNDGR 916
FKTTA G+ L DFI L + + + F+ ++G+G ++V ND +
Sbjct: 819 FKTTALSGVFLENLGI-----KDFIRLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQ 873
Query: 917 WHRVKAVRDGQSGKITVDDY--GARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMR 974
WH V+A R+ + + VD+ R G R L +N L+VGG ++RQ +
Sbjct: 874 WHYVRAERNLKETSLQVDNLPRSTRETSEEGHFR-LQLNSQLFVGGT------SSRQ--K 924
Query: 975 GLVGCISHFTLS 986
G +GCI L+
Sbjct: 925 GFLGCIRSLHLN 936
Score = 43.5 bits (101), Expect = 0.001
Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 828 EIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 887
++ F GRS L Y K +S + + ++FK+ DG+L + G+ D I+L
Sbjct: 179 DVADFDGRSSLLYRFNQ--KLMSTLKDVISLKFKSMQGDGVL-FHGEGQ---RGDHITLE 232
Query: 888 LRDGALVFSYNLG-------SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGART 940
L+ G L NLG S + S + +D WH V R G+ TVD + +
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQVNFTVDKH-TQH 291
Query: 941 GKSPGMMRQLNINGALYVGGM 961
++ G L+I+ L GG+
Sbjct: 292 FRTKGETDALDIDYELSFGGI 312
Score = 42.7 bits (99), Expect = 0.002
Identities = 56/234 (23%), Positives = 95/234 (40%), Gaps = 15/234 (6%)
Query: 379 SCSEDIVIQYPQFFGHSYVTFEPLKNSYQ--AFQITLEFRAEAEDGLLLYCGENEHGRGD 436
SCSE ++ P F +S ++ L + Q ++ +FR +DGLLL +E
Sbjct: 359 SCSEPQIV--PITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEGSGTL 416
Query: 437 FMSL--AIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPV 493
+SL I+R +Q VA I++ + + G WH+V + L L++ P
Sbjct: 417 LLSLEGGILRLVIQ---KMTERVAEILTGSNLNDGLWHSVSINARRNRITLTLDDEAAPP 473
Query: 494 TGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLG 553
S + +I Y GG P + + FQGC++ + ++ + D+ G
Sbjct: 474 APDST--WVQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQG 531
Query: 554 KA--LSGADVGECS-SGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDA 604
S + CS C C HGG+C+ Y + G C ++
Sbjct: 532 SLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCHNS 585
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 86.3 bits (212), Expect = 1e-16
Identities = 94/388 (24%), Positives = 157/388 (40%), Gaps = 64/388 (16%)
Query: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 692
S+ + + D +L Y DFL+I + G V F +D GSG G + D LT+
Sbjct: 2166 SYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPD-LTI 2224
Query: 693 GN--WHELRVSRTAKNGILQV-----DKQKIV----EGMAEGGFT--QIKCNTDIFIGGV 739
+ W+ + SRT +NG + V K IV + G+T + N +F+GG+
Sbjct: 2225 DDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGL 2284
Query: 740 PNYDDVKKNSGV-LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGS 798
+KK V + F+G + + +++ I G
Sbjct: 2285 TG--KLKKADAVRVITFTGCMGETYFDNKPI---------------------------GL 2315
Query: 799 CRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFM 858
R++ DC +G + ++ QF G Y P R + S V
Sbjct: 2316 WNFREKEGDC------KGCTVSPQVEDSEGTIQFDGEGYALVSRPI---RWYPNISTVMF 2366
Query: 859 RFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWH 918
+F+T + LL++ +R DF+S+ L DG + SY+LGSG+AS++ N + NDG+W
Sbjct: 2367 KFRTFSSSALLMYLATRDLR---DFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWK 2423
Query: 919 RVKAVRDGQSGKITVDDYG-------ARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQ 971
R + I++ D A + L + +Y GG+ +
Sbjct: 2424 SFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEV 2483
Query: 972 YMRGLVGCISHFTLS-TDYHISLVEDAV 998
++ GC+ +S T Y+I D V
Sbjct: 2484 NLKKYSGCLKDIEISRTPYNILSSPDYV 2511
Score = 85.9 bits (211), Expect = 2e-16
Identities = 142/617 (23%), Positives = 246/617 (39%), Gaps = 117/617 (18%)
Query: 390 QFFGHSY-VTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 448
QF G Y + P++ + +FR + LL+Y + DFMS+ + ++
Sbjct: 2342 QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD--LRDFMSVELTDGHIK 2399
Query: 449 FRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQL-----NNGTPVTGQSQGQYSK 503
++ G+G+A +VS G W + L R + + N + S G
Sbjct: 2400 VSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFG 2459
Query: 504 ITFRTP--LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADV 561
+ + +Y GG P+ L R + + GC++ + I P+ +
Sbjct: 2460 LDLKADDKIYFGGLPTLRNL-RPEVNLKKYSGCLKDI-----EISRTPYNI--------- 2504
Query: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQ--FRESLRSY 619
+ + Y+ + KG E+ +T++ P+ F E
Sbjct: 2505 ---------------------LSSPDYVGVT----KGCSLENVYTVSFPKPGFVE----- 2534
Query: 620 AATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSY------------DTGSKDFLSINLA 667
+P P++ E ++F + G++L TG ++ I L
Sbjct: 2535 -LSPVPIDVG-----TEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYV-ILLN 2587
Query: 668 GGHVEFRFDCGSGTG---VLRSEDPLTL-GNWHELRVSRTAKNGILQVDK-QKIVEGMAE 722
G +E G+ T V+R E L G H + V RT +QVD+ ++ ++ +
Sbjct: 2588 RGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTV 2647
Query: 723 GGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVE 782
++K +F+GG P + PF G I +++N V DF V+ +
Sbjct: 2648 EQPIEVK---KLFVGGAPPEFQPSPLRNI-PPFEGCIWNLVINS----VPMDFARPVSFK 2699
Query: 783 NA-----AHPCVR------APCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAIIEAIEI- 829
NA AH +R AP P + P+ G C A+ I
Sbjct: 2700 NADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHG-PCAAESEPALLIG 2758
Query: 830 -PQF-IGRSY---LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFI 884
QF + R+ + +D+ + R++ + + +T A+ GLL + ++DF
Sbjct: 2759 SKQFGLSRNSHIAIAFDDTKVKNRLT-----IELEVRTEAESGLLFYMARIN---HADFA 2810
Query: 885 SLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSP 944
++ LR+G FSY+LGSG M+ NDG+WH++K +R Q G + VD RT SP
Sbjct: 2811 TVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT-ISP 2869
Query: 945 GMMRQLNINGALYVGGM 961
L++ G LYVGG+
Sbjct: 2870 KKADILDVVGMLYVGGL 2886
Score = 73.9 bits (180), Expect = 7e-13
Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 62/381 (16%)
Query: 394 HSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNC 453
H + F+ K + I LE R EAE GLL Y H DF ++ + F ++
Sbjct: 2769 HIAIAFDDTKVKNR-LTIELEVRTEAESGLLFYMARINHA--DFATVQLRNGLPYFSYDL 2825
Query: 454 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLG 513
G+G + TKI G WH + + R G+L ++ + T S + + LY+G
Sbjct: 2826 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT-ISPKKADILDVVGMLYVG 2884
Query: 514 GAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEAS 573
G P Y R GCV++L + E + + S
Sbjct: 2885 GLPINYTTRRIGPVTYSIDGCVRNL---------------------HMAEAPADLEQPTS 2923
Query: 574 CIHGGTCTA-IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYL 632
H GTC A + +Y F G F + F+ L
Sbjct: 2924 SFHVGTCFANAQRGTY-------FDG----TGFAKAVGGFKVGLD--------------- 2957
Query: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG--TGVLRSEDP- 689
+EFE FR + GVLL + D + I + + F D G+G T V + P
Sbjct: 2958 LLVEFE--FRTTTTTGVLL-GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPG 3014
Query: 690 -LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKN 748
L G WH++ ++ L VD ++ T N +F+GG P DD+K+
Sbjct: 3015 HLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFP--DDLKQF 3072
Query: 749 SGVLK-PFSGSIQKIILNDRT 768
PF G I+ + L T
Sbjct: 3073 GLTTSIPFRGCIRSLKLTKGT 3093
Score = 67.0 bits (162), Expect = 8e-11
Identities = 107/507 (21%), Positives = 182/507 (35%), Gaps = 102/507 (20%)
Query: 510 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLGKALSGADVGECSSGI 568
L++GGAP + F+GC+ +L +N +D RP + AD+G C+
Sbjct: 2656 LFVGGAPPEFQPSPLRNIPP-FEGCIWNLVINSVPMDFARP----VSFKNADIGRCAHQK 2710
Query: 569 CDEASCIHGGTCTA--------IKADSYICLCPLGFKG---RHCEDAFTLTIPQFRESLR 617
E G A + ++ P+ G E A + QF S
Sbjct: 2711 LREDE---DGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRN 2767
Query: 618 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 677
S+ A + + + + E+ R ++ G+L Y DF ++ L G F +D
Sbjct: 2768 SHIAIAF--DDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDL 2825
Query: 678 GSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT----- 732
GSG + G WH++++ R+ + GIL VD G + + K +
Sbjct: 2826 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVD------GASNRTISPKKADILDVVG 2879
Query: 733 DIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAP 792
+++GG+P ++ V G ++ + + + ++ +S
Sbjct: 2880 MLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSS--------------- 2924
Query: 793 CAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY-DNPDILKRVSG 851
H G+C F TY D K V G
Sbjct: 2925 -FHVGTC--------------------------------FANAQRGTYFDGTGFAKAVGG 2951
Query: 852 SRSN----VFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG----V 903
+ V F+TT G+LL M D + + + D L+F + G+G V
Sbjct: 2952 FKVGLDLLVEFEFRTTTTTGVLLGISSQKM----DGMGIEMIDEKLMFHVDNGAGRFTAV 3007
Query: 904 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG--- 960
V G DG+WH+V A + ++TVD + N ++VGG
Sbjct: 3008 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3067
Query: 961 -MKEIALHTNRQYMRGLVGCISHFTLS 986
+K+ L T+ + GCI L+
Sbjct: 3068 DLKQFGLTTSIPFR----GCIRSLKLT 3090
Score = 61.6 bits (148), Expect = 4e-09
Identities = 85/411 (20%), Positives = 157/411 (38%), Gaps = 71/411 (17%)
Query: 398 TFEP--LKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT 455
T++P K SY I + + D LL Y G + DF+++ + + + F ++ G+
Sbjct: 2157 TYKPEIKKGSYN--NIVVNVKTAVADNLLFYLGSAKFI--DFLAIEMRKGKVSFLWDVGS 2212
Query: 456 GVAII-VSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG 514
GV + + I W+ ++ R G NG + + G + I T +
Sbjct: 2213 GVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVR-------ALDGPKASIVPST--HHST 2263
Query: 515 APSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASC 574
+P Y ++ F G + +G +A
Sbjct: 2264 SPPGYTILDVDANAMLFVGGL------------------------------TGKLKKADA 2293
Query: 575 IHGGTCTAIKADSYICLCPLG---FKGRHCEDAFTLTIPQFRESL-------RSYAATPW 624
+ T T ++Y P+G F+ + + PQ +S YA
Sbjct: 2294 VRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSR 2353
Query: 625 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 684
P+ +S + F+ FR S +L+Y +DF+S+ L GH++ +D GSG +
Sbjct: 2354 PIRWYPNISTVMFK--FRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASV 2411
Query: 685 RSEDPLTLGNWHELRVSRTAKN---GILQVD---KQKIVEGMAEGGF-TQIKCNTDIFIG 737
S G W +SR K I+ +D ++ I + F +K + I+ G
Sbjct: 2412 VSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFG 2471
Query: 738 GVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD-----FTSGVNVEN 783
G+P +++ LK +SG ++ I ++ ++ T G ++EN
Sbjct: 2472 GLPTLRNLRPEVN-LKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLEN 2521
Score = 52.0 bits (123), Expect = 3e-06
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 18/131 (13%)
Query: 843 PDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG 902
P+I K GS +N+ + KT D LL + G + DF+++ +R G + F +++GSG
Sbjct: 2160 PEIKK---GSYNNIVVNVKTAVADNLLFYLGSAKF---IDFLAIEMRKGKVSFLWDVGSG 2213
Query: 903 VASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGA----------RTGKSPG-MMRQL 950
V + + + +D W+R+ A R G++G I+V + PG + +
Sbjct: 2214 VGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDV 2273
Query: 951 NINGALYVGGM 961
+ N L+VGG+
Sbjct: 2274 DANAMLFVGGL 2284
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 85.1 bits (209), Expect = 3e-16
Identities = 142/620 (22%), Positives = 246/620 (39%), Gaps = 119/620 (19%)
Query: 390 QFFGHSY-VTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 448
QF G Y + P++ + +FR + LL+Y + DFMS+ + ++
Sbjct: 2342 QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD--LRDFMSVELTDGHIK 2399
Query: 449 FRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQL-----NNGTPVTGQSQGQYSK 503
++ G+G+A +VS G W + L R + + N + S G
Sbjct: 2400 VSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFG 2459
Query: 504 ITFRTP--LYLGGAPSAYWL---VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSG 558
+ + +Y GG P+ L R + + GC++ + I P+ +
Sbjct: 2460 LDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDI-----EISRTPYNI------ 2508
Query: 559 ADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQ--FRESL 616
+ + Y+ + KG E+ +T++ P+ F E
Sbjct: 2509 ------------------------LSSPDYVGVT----KGCSLENVYTVSFPKPGFVE-- 2538
Query: 617 RSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSY------------DTGSKDFLSI 664
+P P++ E ++F + G++L TG ++ I
Sbjct: 2539 ----LSPVPIDVG-----TEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYV-I 2588
Query: 665 NLAGGHVEFRFDCGSGTG---VLRSEDPLTL-GNWHELRVSRTAKNGILQVDK-QKIVEG 719
L G +E G+ T V+R E L G H + V RT +QVD+ ++ ++
Sbjct: 2589 LLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQN 2648
Query: 720 MAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGV 779
+ ++K +F+GG P + PF G I +++N V DF V
Sbjct: 2649 LTVEQPIEVK---KLFVGGAPPEFQPSPLRNI-PPFEGCIWNLVINS----VPMDFARPV 2700
Query: 780 NVENA-----AHPCVR------APCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAIIEAI 827
+ +NA AH +R AP P + P+ G C A+
Sbjct: 2701 SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHG-PCAAESEPAL 2759
Query: 828 EI--PQF-IGRSY---LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 881
I QF + R+ + +D+ + R++ + + +T A+ GLL + ++
Sbjct: 2760 LIGSKQFGLSRNSHIAIAFDDTKVKNRLT-----IELEVRTEAESGLLFYMARIN---HA 2811
Query: 882 DFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTG 941
DF ++ LR+G FSY+LGSG M+ NDG+WH++K +R Q G + VD RT
Sbjct: 2812 DFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT- 2870
Query: 942 KSPGMMRQLNINGALYVGGM 961
SP L++ G LYVGG+
Sbjct: 2871 ISPKKADILDVVGMLYVGGL 2890
Score = 83.6 bits (205), Expect = 9e-16
Identities = 94/392 (23%), Positives = 161/392 (41%), Gaps = 68/392 (17%)
Query: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 692
S+ + + D +L Y DFL+I + G V F +D GSG G + D LT+
Sbjct: 2166 SYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPD-LTI 2224
Query: 693 GN--WHELRVSRTAKNGILQV-----DKQKIV----EGMAEGGFT--QIKCNTDIFIGGV 739
+ W+ + SRT +NG + V K IV + G+T + N +F+GG+
Sbjct: 2225 DDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGL 2284
Query: 740 PNYDDVKKNSGV-LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGS 798
+KK V + F+G + + +++ I G
Sbjct: 2285 TG--KLKKADAVRVITFTGCMGETYFDNKPI---------------------------GL 2315
Query: 799 CRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFM 858
R++ DC +G + ++ QF G Y P R + S V
Sbjct: 2316 WNFREKEGDC------KGCTVSPQVEDSEGTIQFDGEGYALVSRPI---RWYPNISTVMF 2366
Query: 859 RFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWH 918
+F+T + LL++ +R DF+S+ L DG + SY+LGSG+AS++ N + NDG+W
Sbjct: 2367 KFRTFSSSALLMYLATRDLR---DFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWK 2423
Query: 919 RVKAVRDGQSGKITVDDYG-------ARTGKSPGMMRQLNINGALYVGG---MKEIALHT 968
R + I++ D A + L + +Y GG ++ +++
Sbjct: 2424 SFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKA 2483
Query: 969 NRQY-MRGLVGCISHFTLS-TDYHISLVEDAV 998
+ ++ GC+ +S T Y+I D V
Sbjct: 2484 RPEVNLKKYSGCLKDIEISRTPYNILSSPDYV 2515
Score = 73.9 bits (180), Expect = 7e-13
Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 62/381 (16%)
Query: 394 HSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNC 453
H + F+ K + I LE R EAE GLL Y H DF ++ + F ++
Sbjct: 2773 HIAIAFDDTKVKNR-LTIELEVRTEAESGLLFYMARINHA--DFATVQLRNGLPYFSYDL 2829
Query: 454 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLG 513
G+G + TKI G WH + + R G+L ++ + T S + + LY+G
Sbjct: 2830 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT-ISPKKADILDVVGMLYVG 2888
Query: 514 GAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEAS 573
G P Y R GCV++L + E + + S
Sbjct: 2889 GLPINYTTRRIGPVTYSIDGCVRNL---------------------HMAEAPADLEQPTS 2927
Query: 574 CIHGGTCTA-IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYL 632
H GTC A + +Y F G F + F+ L
Sbjct: 2928 SFHVGTCFANAQRGTY-------FDG----TGFAKAVGGFKVGLD--------------- 2961
Query: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG--TGVLRSEDP- 689
+EFE FR + GVLL + D + I + + F D G+G T V + P
Sbjct: 2962 LLVEFE--FRTTTTTGVLL-GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPG 3018
Query: 690 -LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKN 748
L G WH++ ++ L VD ++ T N +F+GG P DD+K+
Sbjct: 3019 HLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFP--DDLKQF 3076
Query: 749 SGVLK-PFSGSIQKIILNDRT 768
PF G I+ + L T
Sbjct: 3077 GLTTSIPFRGCIRSLKLTKGT 3097
Score = 67.0 bits (162), Expect = 8e-11
Identities = 107/507 (21%), Positives = 182/507 (35%), Gaps = 102/507 (20%)
Query: 510 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLGKALSGADVGECSSGI 568
L++GGAP + F+GC+ +L +N +D RP + AD+G C+
Sbjct: 2660 LFVGGAPPEFQPSPLRNIPP-FEGCIWNLVINSVPMDFARP----VSFKNADIGRCAHQK 2714
Query: 569 CDEASCIHGGTCTA--------IKADSYICLCPLGFKG---RHCEDAFTLTIPQFRESLR 617
E G A + ++ P+ G E A + QF S
Sbjct: 2715 LREDE---DGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRN 2771
Query: 618 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 677
S+ A + + + + E+ R ++ G+L Y DF ++ L G F +D
Sbjct: 2772 SHIAIAF--DDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDL 2829
Query: 678 GSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT----- 732
GSG + G WH++++ R+ + GIL VD G + + K +
Sbjct: 2830 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVD------GASNRTISPKKADILDVVG 2883
Query: 733 DIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAP 792
+++GG+P ++ V G ++ + + + ++ +S
Sbjct: 2884 MLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSS--------------- 2928
Query: 793 CAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY-DNPDILKRVSG 851
H G+C F TY D K V G
Sbjct: 2929 -FHVGTC--------------------------------FANAQRGTYFDGTGFAKAVGG 2955
Query: 852 SRSN----VFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG----V 903
+ V F+TT G+LL M D + + + D L+F + G+G V
Sbjct: 2956 FKVGLDLLVEFEFRTTTTTGVLLGISSQKM----DGMGIEMIDEKLMFHVDNGAGRFTAV 3011
Query: 904 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG--- 960
V G DG+WH+V A + ++TVD + N ++VGG
Sbjct: 3012 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3071
Query: 961 -MKEIALHTNRQYMRGLVGCISHFTLS 986
+K+ L T+ + GCI L+
Sbjct: 3072 DLKQFGLTTSIPFR----GCIRSLKLT 3094
Score = 59.7 bits (143), Expect = 1e-08
Identities = 85/414 (20%), Positives = 157/414 (37%), Gaps = 73/414 (17%)
Query: 398 TFEP--LKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT 455
T++P K SY I + + D LL Y G + DF+++ + + + F ++ G+
Sbjct: 2157 TYKPEIKKGSYN--NIVVNVKTAVADNLLFYLGSAKFI--DFLAIEMRKGKVSFLWDVGS 2212
Query: 456 GVAII-VSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG 514
GV + + I W+ ++ R G NG + + G + I T +
Sbjct: 2213 GVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVR-------ALDGPKASIVPST--HHST 2263
Query: 515 APSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASC 574
+P Y ++ F G + +G +A
Sbjct: 2264 SPPGYTILDVDANAMLFVGGL------------------------------TGKLKKADA 2293
Query: 575 IHGGTCTAIKADSYICLCPLG---FKGRHCEDAFTLTIPQFRESL-------RSYAATPW 624
+ T T ++Y P+G F+ + + PQ +S YA
Sbjct: 2294 VRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSR 2353
Query: 625 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 684
P+ +S + F+ FR S +L+Y +DF+S+ L GH++ +D GSG +
Sbjct: 2354 PIRWYPNISTVMFK--FRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASV 2411
Query: 685 RSEDPLTLGNWHELRVSRTAKN---GILQVD---KQKIVEGMAEGGF-TQIKCNTDIFIG 737
S G W +SR K I+ +D ++ I + F +K + I+ G
Sbjct: 2412 VSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFG 2471
Query: 738 GVPNYDDVKKNSGV---LKPFSGSIQKIILNDRTIHVKHD-----FTSGVNVEN 783
G+P ++ + LK +SG ++ I ++ ++ T G ++EN
Sbjct: 2472 GLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLEN 2525
Score = 52.0 bits (123), Expect = 3e-06
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 18/131 (13%)
Query: 843 PDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG 902
P+I K GS +N+ + KT D LL + G + DF+++ +R G + F +++GSG
Sbjct: 2160 PEIKK---GSYNNIVVNVKTAVADNLLFYLGSAKF---IDFLAIEMRKGKVSFLWDVGSG 2213
Query: 903 VASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGA----------RTGKSPG-MMRQL 950
V + + + +D W+R+ A R G++G I+V + PG + +
Sbjct: 2214 VGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDV 2273
Query: 951 NINGALYVGGM 961
+ N L+VGG+
Sbjct: 2274 DANAMLFVGGL 2284
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 84.3 bits (207), Expect = 5e-16
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 49/303 (16%)
Query: 346 PCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNS 405
PCD C + C+ CQC G GE C + + + + SY+ K
Sbjct: 1124 PCDNFDCQNGAQCI--VRINEPICQCLPGYQGEKCEKLVSVNFIN--KESYLQIPSAKVR 1179
Query: 406 YQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVA-IIVSET 464
Q ITL+ + + G+LLY G+ +H +++ + R ++ ++ G+ A I S
Sbjct: 1180 PQT-NITLQIATDEDSGILLYKGDKDH-----IAVELYRGRVRASYDTGSHPASAIYSVE 1233
Query: 465 KIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP---SAYWL 521
I G +H V L + L ++ G P + + S + F +PLY+GG P + L
Sbjct: 1234 TINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASL 1293
Query: 522 VRATGTN-RGFQGCVQSLAVNGRRIDMRPWPL------------------GKALSGADVG 562
+A G N F GC+++L +N D + P+ G + G
Sbjct: 1294 RQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAG 1353
Query: 563 ---ECSSG----ICDEAS--------CIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTL 607
EC G +CD+ + C+H GTC I A SY C C G G C++ L
Sbjct: 1354 FTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYSCKCLEGHGGVLCDEEEDL 1412
Query: 608 TIP 610
P
Sbjct: 1413 FNP 1415
Score = 74.7 bits (182), Expect = 4e-13
Identities = 64/266 (24%), Positives = 117/266 (43%), Gaps = 34/266 (12%)
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 628
CD C +G C ++ + IC C G++G CE ++ L+ +A + P
Sbjct: 1125 CDNFDCQNGAQCI-VRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAK---VRP 1180
Query: 629 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG-TGVLRSE 687
Q ++ + D G+LLY G KD +++ L G V +D GS + S
Sbjct: 1181 QTNIT-----LQIATDEDSGILLYK---GDKDHIAVELYRGRVRASYDTGSHPASAIYSV 1232
Query: 688 DPLTLGNWHELRVSRTAKNGILQVD--KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV 745
+ + GN+H + + ++ L VD KI+ +++ + + ++ +++GG+P +V
Sbjct: 1233 ETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQ--STLNFDSPLYVGGMPGKSNV 1290
Query: 746 KK------NSGVLKPFSGSIQKIILNDRTIHVKHDFTS---GVNVENAAHPCVRAPCAHG 796
+G F G I+ + +N DF + PC + CAH
Sbjct: 1291 ASLRQAPGQNGT--SFHGCIRNLYINSEL----QDFQKVPMQTGILPGCEPCHKKVCAH- 1343
Query: 797 GSCRPRKE-GYDCDCPLGFEGLHCQK 821
G+C+P + G+ C+C G+ G C +
Sbjct: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQ 1369
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/177 (28%), Positives = 82/177 (46%), Gaps = 18/177 (10%)
Query: 787 PCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR-SYLTYDNPDI 845
PC C +G C R C C G++G C+K + FI + SYL + +
Sbjct: 1124 PCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSV-----NFINKESYLQIPSAKV 1178
Query: 846 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 905
+ +N+ ++ T G+LL++GD D I++ L G + SY+ GS AS
Sbjct: 1179 RPQ-----TNITLQIATDEDSGILLYKGDK------DHIAVELYRGRVRASYDTGSHPAS 1227
Query: 906 IMVN-GSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 961
+ + + NDG +H V+ + QS ++VD + + LN + LYVGGM
Sbjct: 1228 AIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGM 1284
Score = 42.0 bits (97), Expect = 0.003
Identities = 17/46 (36%), Positives = 27/46 (58%), Gaps = 3/46 (6%)
Query: 778 GVNVENAAHPCVRAPCAHGGSCRPR---KEGYDCDCPLGFEGLHCQ 820
G + + H C+ PC HGG+C + ++G+ C C GFEG +C+
Sbjct: 951 GQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCE 996
Score = 41.2 bits (95), Expect = 0.005
Identities = 31/124 (25%), Positives = 46/124 (37%), Gaps = 15/124 (12%)
Query: 722 EGGFTQIKCNTDIFIGGVPNYDDVK------------KNSGVLKPFSGS--IQKIILNDR 767
EG F + + + IG P Y D K G+ + K++L
Sbjct: 842 EGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTP 901
Query: 768 TIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRK-EGYDCDCPLGFEGLHCQKAIIEA 826
+ VN+ +PC+ PC + G+C + Y C CP GF+G C I
Sbjct: 902 SKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC 961
Query: 827 IEIP 830
I P
Sbjct: 962 ISNP 965
Score = 40.8 bits (94), Expect = 0.006
Identities = 34/136 (25%), Positives = 57/136 (41%), Gaps = 14/136 (10%)
Query: 479 DGLNGLLQLN-NGTPVTGQSQGQYSKITFRTPLYLGGAP-----SAYWL---VRATGTNR 529
DGL L L+ +G ++ +G ++ ++ + L +G P + WL V++
Sbjct: 822 DGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEP 881
Query: 530 GFQGCVQSLAVNGRRIDMRPWPLGKALSGADVG---ECSSGICDEASCIHGGTCTAIKAD 586
G C + + + P DV +C+ C C + GTC + D
Sbjct: 882 GIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNP--CLSNPCKNDGTCNSDPVD 939
Query: 587 SYICLCPLGFKGRHCE 602
Y C CP GFKG+ C+
Sbjct: 940 FYRCTCPYGFKGQDCD 955
Score = 35.4 bits (80), Expect = 0.27
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 569 CDEASCIHGGTCTAIKA--DSYICLCPLGFKGRHCE 602
C C HGGTC + D + C+C GF+G +CE
Sbjct: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCE 996
Score = 35.0 bits (79), Expect = 0.36
Identities = 12/28 (42%), Positives = 15/28 (53%)
Query: 792 PCAHGGSCRPRKEGYDCDCPLGFEGLHC 819
PC H C +G+ CDC G+ G HC
Sbjct: 1046 PCQHDSKCILTPKGFKCDCTPGYVGEHC 1073
Score = 30.8 bits (68), Expect = 6.7
Identities = 12/35 (34%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCED 603
C++ C + TC ++Y CLCP + G CE+
Sbjct: 1002 CEDNDCENNSTCVD-GINNYTCLCPPEYTGELCEE 1035
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 81.3 bits (199), Expect = 4e-15
Identities = 65/205 (31%), Positives = 94/205 (45%), Gaps = 17/205 (8%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG+ PP+ + + ++ WK P G SPI GY + E A + + +
Sbjct: 19488 PGRCDPPV---ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPI-I 19543
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
R + T L+ GTEY + A ++AG G+ S ++D PP P P V
Sbjct: 19544 ERTLKAT-----GLQEGTEYEFRVTAINKAGPGKPSDASKAA-YARDPQYPPGPPAFPKV 19597
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT--SIHERIQMDSMVIKGLDP 208
+ S V+LSW A +G +PI Y VE R D D W ++ + +Q + GL
Sbjct: 19598 YDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSD-NWVRCNLPQNLQKTRFEVTGLME 19656
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDI 233
DT YQF V A+N G S PSD+
Sbjct: 19657 DTQYQFRVYAVNKIGYSD---PSDV 19678
Score = 77.0 bits (188), Expect = 8e-14
Identities = 64/207 (30%), Positives = 96/207 (46%), Gaps = 11/207 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + A ++ W P G SPI GY V + DK ++ + +P+
Sbjct: 13884 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR--CNKMPVK--- 13938
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
TT V G L +YR + A + AG G+ S L +D PP P +P V V
Sbjct: 13939 DTTYRVKG-LTNKKKYRFRVLAENLAGPGKPSKSTE-PILIKDPIDPPWPPGKPTVKDVG 13996
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
+ V L+W +G A I+ Y +E ++ D +W + E + ++ GL Y F
Sbjct: 13997 KTSVRLNWTKPEHDGGAKIESYVIEMLKTGTD-EWVRVAEGVPTTQHLLPGLMEGQEYSF 14055
Query: 215 AVRAMNSHGPSPRSWPSDIIRTLCPEE 241
VRA+N G S S PSD + LC E+
Sbjct: 14056 RVRAVNKAGESEPSEPSDPV--LCREK 14080
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/213 (26%), Positives = 94/213 (44%), Gaps = 13/213 (6%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFY 72
+ S L + R++IR PG PP +++ ++ ++ W P G S + GY V
Sbjct: 29914 IGSYLQSEVIECRSSIRIPG---PPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVER 29970
Query: 73 SEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT 132
EV AD+ ++ V ++R T L G EY + A + G G+ S P
Sbjct: 29971 KEVRADRWVRVNKVPVTMTRYRST------GLTEGLEYEHRVTAINARGSGKPSRPSK-P 30023
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
++ D PP PQ P V + + V+L+W EG + + Y +E + D +WT
Sbjct: 30024 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVD-QHEWTKC 30082
Query: 193 HER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGP 224
+ ++ + L Y+F V A N+ GP
Sbjct: 30083 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGP 30115
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/207 (28%), Positives = 92/207 (44%), Gaps = 26/207 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSE------VGADKSLQEQLHSV 88
GPP + + + ++W+ P++ G PI Y + E V A K+
Sbjct: 14185 GPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAG------ 14238
Query: 89 PLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
P + D+ GTE + + A ++AG G S P + ++ +D PP+ P
Sbjct: 14239 ------PDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI-EDPTSPPSPPLDL 14291
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD--SMVIKGL 206
HV +A++WKP G +PI Y VE P +KW ++ R D V +G+
Sbjct: 14292 HVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMC-PVGTEKWMRVNSRPIKDLKFKVEEGV 14350
Query: 207 DPDTNYQFAVRAMNSHGPSPRSWPSDI 233
PD Y VRA+N+ G S PS+I
Sbjct: 14351 VPDKEYVLRVRAVNAIGVSE---PSEI 14374
Score = 70.5 bits (171), Expect = 8e-12
Identities = 67/239 (28%), Positives = 106/239 (44%), Gaps = 18/239 (7%)
Query: 26 RAAIRKPGKV-GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQE 83
+ I+ P ++ GPP K+ A + + W P + GSPI GY + E G+
Sbjct: 15589 KVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSP--YWS 15646
Query: 84 QLHSVPLSR-DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
++ P+++ + E + L G +Y+ A + AG G S P ++ D PP
Sbjct: 15647 RVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSD-PEVAGDPIFPP 15705
Query: 143 AAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHE---RIQMD 199
P P V + S ++L WKP A +G +PI+ Y VE ++ + W ++E I
Sbjct: 15706 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVE-MQEEGTTDWKRVNEPDKLITTC 15764
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ L Y+F V+A+N G S P +I T EE P D+GA
Sbjct: 15765 ECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEE-------PEVFIDIGA 15816
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/226 (26%), Positives = 100/226 (44%), Gaps = 23/226 (10%)
Query: 10 RLLLLASSL-GPGAVS-------LRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP 61
R +LA +L GPG S ++ I P G P +G T+ + W P H
Sbjct: 13954 RFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK---TSVRLNWTKPEHD 14010
Query: 62 G-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + I Y + + G D+ ++ ++ +PTT+ ++ L G EY + A ++A
Sbjct: 14011 GGAKIESYVIEMLKTGTDEWVR-------VAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 14063
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G+ S P L ++ PP+ P+ VI ++ + L W +G +PI Y VE
Sbjct: 14064 GESEPSEPSD-PVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE- 14121
Query: 181 IRPDFDKK-WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ D +K W ++ ++ + L + Y F V A N+ G S
Sbjct: 14122 -KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS 14166
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/233 (25%), Positives = 102/233 (43%), Gaps = 13/233 (5%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
+ L + LG S+ ++ G GP DIK + ++ + W+ P G +PIL Y +
Sbjct: 14459 ITLENKLGSATASIN--VKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVL 14516
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
E G + +P+ + DL P EY + A ++ G G ++
Sbjct: 14517 ERREAG-------RRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 14569
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
++QD PP P V + + ++WKP +G + I Y +E I +++W
Sbjct: 14570 -PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKG-EERWK 14627
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
+E + + + KGL+ YQF VRA N+ G S S + + + P +A
Sbjct: 14628 RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDA 14680
Score = 69.3 bits (168), Expect = 2e-11
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 19/216 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADK 79
G+ S ++ K GPP +K+ + + W+ P G S I Y V DK
Sbjct: 19375 GSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIV-------DK 19427
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQD 137
+ + +S +P T + L G EY+ I A ++ G G + P ++++
Sbjct: 19428 RETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP----AIAKN 19483
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
PP P + ++ + +SWKP A +G +PI Y +E R WT ++ + I
Sbjct: 19484 PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLE-KRETQAVNWTKVNRKPI 19542
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
++ GL T Y+F V A+N GP PSD
Sbjct: 19543 IERTLKATGLQEGTEYEFRVTAINKAGPGK---PSD 19575
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/213 (27%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP D+K+ + + + WKMP G I GY + +K + ++ D
Sbjct: 15913 GPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVI-------EKRTIDGKAWTKVNPDC 15965
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+T V+ DL +Y + A ++ G G TT ++D PP P + + +++
Sbjct: 15966 GSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT-ARDPIYPPDPPIKLKIGLIT 16024
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIR--PDFDKK--WTSIHER-IQMDSMVIKGLDPD 209
+ V LSWKP ++G +P+ +Y VE + P KK W ++R ++ ++ L
Sbjct: 16025 KNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEG 16084
Query: 210 TNYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V+A+N+ G PS P D R P
Sbjct: 16085 GEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMP 16117
Score = 67.8 bits (164), Expect = 5e-11
Identities = 55/212 (25%), Positives = 91/212 (42%), Gaps = 22/212 (10%)
Query: 38 PLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P ++K G + + + W+ P G SP+ GY V EV + L +P
Sbjct: 13491 PKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP- 13549
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGR---LSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
DL G EY + A ++ G G + P +++T P P P +
Sbjct: 13550 ------DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMST-------PATVPDPPENVKW 13596
Query: 154 SD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
D + + L+W P ++G + I+ Y VE P KW + E + M + GL+
Sbjct: 13597 RDRTANSIFLTWDPPKNDGGSRIKGYIVERC-PRGSDKWVACGEPVAETKMEVTGLEEGK 13655
Query: 211 NYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V+A+N G S S P++ I+ + +EA
Sbjct: 13656 WYAYRVKALNRQGASKPSRPTEEIQAVDTQEA 13687
Score = 67.8 bits (164), Expect = 5e-11
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 15/214 (7%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
L + + G VS++ + K GPP D+++ + + + WK P G S I Y V
Sbjct: 17289 LTVENPAGSKTVSVKVLVLD--KPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVV 17346
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPR 129
+V + + PLS L G +Y +AA +Q G+G + +P+
Sbjct: 17347 ERRDVASAQWS-------PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPK 17399
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D PP P+ H + V +EV+L W +G +PI Y VE+ + + + W
Sbjct: 17400 PIKAL--DPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEY-QEEGTQDW 17456
Query: 190 TSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
++ V+ GL Y+F V+A N G
Sbjct: 17457 IKFKTVTNLE-CVVTGLQQGKTYRFRVKAENIVG 17489
Score = 66.6 bits (161), Expect = 1e-10
Identities = 58/197 (29%), Positives = 82/197 (41%), Gaps = 11/197 (5%)
Query: 49 TAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPG 107
++ S+ W P+ G S + GY + E DK ++ I TT + L P
Sbjct: 30344 SSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHN------KTQITTTMYTVTGLVPD 30397
Query: 108 TEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGAS 167
EY+ I A + G +SP + +D P+ P + ++ +S V L W+
Sbjct: 30398 AEYQFRIIAQNDVGLSE-TSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPEC 30456
Query: 168 EGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS- 225
+G I Y VE+ R D W S ERI+ I GL T Y+F V A N G S
Sbjct: 30457 DGGKEILGYWVEY-RQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSR 30515
Query: 226 PRSWPSDIIRTLCPEEA 242
PR I L EA
Sbjct: 30516 PRRTAMSIKTKLTSGEA 30532
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/201 (27%), Positives = 85/201 (42%), Gaps = 12/201 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP +++ ++ ++ W P G SPI Y + +K +L +S DI
Sbjct: 20474 GPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYIL-------EKRETSRLLWTVVSEDI 20526
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ V L G EY ++A + GKG V + D PP P++P V V+
Sbjct: 20527 QSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMV--DRFGPPGPPEKPEVSNVT 20584
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQ 213
+ +SWK +G + I Y VE R +W +I + + GL + Y+
Sbjct: 20585 KNTATVSWKRPVDDGGSEITGYHVE-RREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYE 20643
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F V A N G P S SD +
Sbjct: 20644 FRVSAENRAGIGPPSEASDSV 20664
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/199 (25%), Positives = 89/199 (44%), Gaps = 13/199 (6%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ ++ + ++ W P G S I GY + E + + ++ V R
Sbjct: 25985 PPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKS 26044
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL--SQDSCLPPAAPQQPHVIVV 153
T L+ G EY + A + AG LS P + L ++D P+ P +P ++
Sbjct: 26045 T------GLREGCEYEYRVYAENAAG---LSLPSETSPLIRAEDPVFLPSPPSKPKIVDS 26095
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
+ + ++W +G API Y+VE+ + D D W + + ++ I GL Y
Sbjct: 26096 GKTTITIAWVKPLFDGGAPITGYTVEYKKSD-DTDWKTSIQSLRGTEYTISGLTTGAEYV 26154
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V+++N G S S SD
Sbjct: 26155 FRVKSVNKVGASDPSDSSD 26173
Score = 63.9 bits (154), Expect = 7e-10
Identities = 55/205 (26%), Positives = 94/205 (45%), Gaps = 21/205 (10%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP LD+K N + W P G S I G+ + + ++H+ +
Sbjct: 15198 GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDA--------KMHTWRQPIET 15249
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV-TTLSQDSCLPPAAPQQPHVIVV 153
++ I L G EY+ + A ++ G G P + L+ D PP +P++
Sbjct: 15250 ERSKCDITGLLEGQEYKFRVIAKNKFGCG---PPVEIGPILAVDPLGPPTSPERLTYTER 15306
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIR---PDFDKKWTSIHERI-QMDSMVIKGLDPD 209
+ S + L WK S G +PIQ Y +E R PDF++ +++R+ S +++ LD
Sbjct: 15307 TKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFER----VNKRLCPTTSFLVENLDEH 15362
Query: 210 TNYQFAVRAMNSHGPSPRSWPSDII 234
Y+F V+A+N G S S P +++
Sbjct: 15363 QMYEFRVKAVNEIGESEPSLPLNVV 15387
Score = 63.5 bits (153), Expect = 9e-10
Identities = 54/204 (26%), Positives = 89/204 (43%), Gaps = 14/204 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ A+ + + W P G + I GY + +K +E + ++
Sbjct: 24903 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYIL-------EKRDKEGVRWTKCNKKT 24955
Query: 95 PTTEEV-IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
T + + L G Y +AA + AG G S P V + D+ PP P P V
Sbjct: 24956 LTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPS-VFYRACDALYPPGPPSNPKVTDT 25014
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMVIKGLDPDTN 211
S S V+L+W +G AP++ Y VE ++ +WT+ +Q + L +T
Sbjct: 25015 SRSSVSLAWSKPIYDGGAPVKGYVVE-VKEAAADEWTTCTPPTGLQGKQFTVTKLKENTE 25073
Query: 212 YQFAVRAMNSHG-PSPRSWPSDII 234
Y F + A+NS G P + P ++
Sbjct: 25074 YNFRICAINSEGVGEPATLPGSVV 25097
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/220 (25%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVP 89
KPG+ PP K+ T + W P + G I GY + +K + VP
Sbjct: 18395 KPGRPDPPEVTKVSKEEMT---VVWNPPEYDGGKSITGYFL-------EKKEKHSTRWVP 18444
Query: 90 LSRD-IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
+++ IP + +L P EY+ + A ++ G G S P +++D PP P
Sbjct: 18445 VNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSR-PVVAKDPIEPPGPPTNF 18503
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-----DKKWTSIHERIQM--DSM 201
V+ + + L W +G API Y VE +RP D+ W + Q+
Sbjct: 18504 RVVDTTKHSITLGWGKPVYDGGAPIIGYVVE-MRPKIADASPDEGWKRCNAAAQLVRKEF 18562
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
+ LD + Y+F V A N G P+++ + P+E
Sbjct: 18563 TVTSLDENQEYEFRVCAQNQVGIGR---PAELKEAIKPKE 18599
Score = 62.8 bits (151), Expect = 2e-09
Identities = 50/191 (26%), Positives = 83/191 (43%), Gaps = 11/191 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + + ++ W P GS I GY + E KSL L I
Sbjct: 27067 GPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY---FLEKRDKKSLG---WFKVLKETI 27120
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + + L ++Y+ + A + AG+G S P + D PP P + + +
Sbjct: 27121 RDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAA-DPIDPPGPPAKIRIADST 27179
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTNY 212
S + L W +G + + Y VE IR +++WT++ + ++ V+ L P NY
Sbjct: 27180 KSSITLGWSKPVYDGGSAVTGYVVE-IRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNY 27238
Query: 213 QFAVRAMNSHG 223
F V A+N G
Sbjct: 27239 YFRVSAVNCAG 27249
Score = 62.4 bits (150), Expect = 2e-09
Identities = 59/214 (27%), Positives = 86/214 (40%), Gaps = 25/214 (11%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSE------VGADKSLQEQL 85
G P + ++ +N + W P G SPI+GY + E V A+ +L
Sbjct: 19090 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL---- 19145
Query: 86 HSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAP 145
+ +TE L G EY I A ++AG S P T +P P
Sbjct: 19146 --------VRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTAR----MPVDPP 19193
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK--KWTSIHERIQMDSMVI 203
+P VI V+ S V+L W +G + I Y VE + DK + + +I +
Sbjct: 19194 GKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTA 19253
Query: 204 KGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTL 237
GL+ YQF A + SP S PSD + L
Sbjct: 19254 TGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 19287
Score = 62.0 bits (149), Expect = 3e-09
Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 19/220 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G S + G+ GPP+ IK +++ ++ W P+ G S I Y + +
Sbjct: 16203 GTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI-------E 16255
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
K + V +S + I L G EY I A ++ G G T + S
Sbjct: 16256 KREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFS 16315
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
P AP +P V V+ + + ++W+ +G +P+ Y +E ++ K+W ++ R +
Sbjct: 16316 V--PGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLE-MKDTTSKRWKRVN-RDPI 16371
Query: 199 DSMV------IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+M + GL ++YQF V A+N+ G P S PSD
Sbjct: 16372 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD 16411
Score = 62.0 bits (149), Expect = 3e-09
Identities = 50/211 (23%), Positives = 96/211 (45%), Gaps = 10/211 (4%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYS 73
L S G++++ I + GPP I++ ++C + +I W P + G G +
Sbjct: 25467 LCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDG----GCQISNY 25522
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
V ++ H V S+ + T I L G+EY+ + A ++ GK S V
Sbjct: 25523 IVEKKETTSTTWHIV--SQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV-- 25578
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH 193
+++ PP P P V+ + S + ++W+ ++G + + Y +E+ + W+ +
Sbjct: 25579 VAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY-KERSSILWSKAN 25637
Query: 194 ERIQMDS-MVIKGLDPDTNYQFAVRAMNSHG 223
+ + D+ M + GLD Y++ V A N G
Sbjct: 25638 KILIADTQMKVSGLDEGLMYEYRVYAENIAG 25668
Score = 60.8 bits (146), Expect = 6e-09
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 20/221 (9%)
Query: 15 ASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYS 73
++ L AV ++ ++PG G P + +++ +QW P + G + I+GY +
Sbjct: 24488 SAPLDSKAVIVQYPFKEPGPPGTPF---VTSISKDQMLVQWHEPVNDGGTKIIGYHLEQK 24544
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
E + L +L+ P I T+ L G EY ++A + G G+ S
Sbjct: 24545 E--KNSILWVKLNKTP----IQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF- 24597
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-DKKW-TS 191
+++D C PP P+ IV++ + V L WK A +G + I Y VE + D D +W +
Sbjct: 24598 VARDPCDPPGRPE---AIVITRNNVTLKWKKPAYDGGSKITGYIVE--KKDLPDGRWMKA 24652
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + GL D Y+F V A N+ G S PSD
Sbjct: 24653 SFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNF--SEPSD 24691
Score = 60.8 bits (146), Expect = 6e-09
Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 19/233 (8%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L L +++G + ++R I KPG G P++ K + ++ W+ P G + T
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPGGPIEFK--TVTAEKITLLWRPPADDGGAKI--TH 27000
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
+ E + + S L I TT ++I G EY + A ++ G G
Sbjct: 27001 YIVEKRETSRVVWSMVSEHLEECIITTTKII----KGNEYIFRVRAVNKYGIGEPLESDS 27056
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-- 188
V +++++ + P P P V ++ + + + W ++G + I Y +E DKK
Sbjct: 27057 V--VAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLE----KRDKKSL 27110
Query: 189 -WTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
W + E I+ + GL +++YQ+ V A+N+ G P S PS+ + P
Sbjct: 27111 GWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADP 27163
Score = 60.8 bits (146), Expect = 6e-09
Identities = 63/227 (27%), Positives = 98/227 (43%), Gaps = 19/227 (8%)
Query: 12 LLLASSLGPGAVSLRA-AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYT 69
L+L + G AV ++ I P PL+ + + + W+ P G + ILGY
Sbjct: 30207 LVLENKCGKKAVYIKVRVIGSPNSPEGPLEYD--DIQVRSVRVSWRPPADDGGADILGYI 30264
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSP 128
+ EV + + + T V+ LK EY ++A +Q G + L S
Sbjct: 30265 LERREV-------PKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSE 30317
Query: 129 RHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
VT + + PP P P V+ V+ S V+LSW +G + + Y +E DK
Sbjct: 30318 EPVTPKTPLN--PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDK 30375
Query: 188 KWTSIHERIQMDSMV--IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
W H + Q+ + + + GL PD YQF + A N G S S S+
Sbjct: 30376 -WVR-HNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASE 30420
Score = 60.5 bits (145), Expect = 8e-09
Identities = 47/201 (23%), Positives = 92/201 (45%), Gaps = 7/201 (3%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
G P + ++ + ++ W+ P + G SP+ GY + + + + ++++ P+
Sbjct: 16318 GAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKR--WKRVNRDPIKAMT 16375
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ L G++Y+ + A + AG G S P T ++D PP P P V +
Sbjct: 16376 LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPAT-ARDPIAPPGPPF-PKVTDWT 16433
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTNYQ 213
S L W P +G + + Y VE+ + + ++W ++ ++ +V+ GL Y+
Sbjct: 16434 KSSADLEWSPPLKDGGSKVTGYIVEY-KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYK 16492
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F VRA+N G +D+I
Sbjct: 16493 FRVRAVNIAGIGEPGEVTDVI 16513
Score = 60.1 bits (144), Expect = 1e-08
Identities = 52/211 (24%), Positives = 92/211 (43%), Gaps = 17/211 (8%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
GPPL++ + +N S+ W+ P + G + T + E+ S++ + D+
Sbjct: 13192 GPPLNVTITDVNRFGVSLTWEPPEYDGGAEI--TNYVIELRDKTSIRWDTAMTVRAEDLS 13249
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + D+ G EY + A ++ G G+ S+ ++ P P P + SD
Sbjct: 13250 AT---VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD----PIERPSPPVNLTSSD 13302
Query: 156 ---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTN 211
S V L W+P +G +PI Y +E D W + ++ + + + GL+
Sbjct: 13303 QTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKD-NWIRCNMKLVPELTYKVTGLEKGNK 13361
Query: 212 YQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V A N G S PS+I+ L ++A
Sbjct: 13362 YLYRVSAENKAGVSD---PSEILGPLTADDA 13389
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/197 (27%), Positives = 78/197 (39%), Gaps = 12/197 (6%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP + + + + W PR G S I Y V D + +L S
Sbjct: 13783 KPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVV--ERRATDSEVWHKLSSTVKDT 13840
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T+ L P EY +AA + G G +T Q PP P +
Sbjct: 13841 NFKATK-----LIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFD--PPGPPTRLEPSD 13893
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKGLDPDTN 211
++ V L+W +G +PI Y VE + PD D KW ++ D+ +KGL
Sbjct: 13894 ITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD-KWVRCNKMPVKDTTYRVKGLTNKKK 13952
Query: 212 YQFAVRAMNSHGPSPRS 228
Y+F V A N GP S
Sbjct: 13953 YRFRVLAENLAGPGKPS 13969
Score = 59.3 bits (142), Expect = 2e-08
Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 18/226 (7%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLS 91
K GPP IK+ ++ T+ +I W+ P G+P+ GY V + L P+S
Sbjct: 29831 KPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWL-------PVS 29883
Query: 92 RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVI 151
+ + L G EY +AA ++ G G + S S P P+ +
Sbjct: 29884 ESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS--SIRIPGPPETLQIF 29941
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEF--IRPDFDKKWTSIHE-RIQMDSMVIKGLDP 208
VS + L+W P +G + + Y VE +R D +W +++ + M GL
Sbjct: 29942 DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRAD---RWVRVNKVPVTMTRYRSTGLTE 29998
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITD 254
Y+ V A+N+ G S PS I + P PR +TD
Sbjct: 29999 GLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPR-VTD 30043
Score = 59.3 bits (142), Expect = 2e-08
Identities = 67/216 (31%), Positives = 95/216 (43%), Gaps = 23/216 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEV--GADKSLQEQLHS 87
KP K P+ I+ AL + I WK P G S I Y V E GA+ L S
Sbjct: 30722 KPDKPTGPIVIE--ALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAIS 30779
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT--LSQDSCLPPAAP 145
V R + TE G +RVS A + G +S P V++ + + P AP
Sbjct: 30780 VTTCRIVNLTENA------GYYFRVS--AQNTFG---ISDPLEVSSVVIIKSPFEKPGAP 30828
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIK 204
+P + V+ ++WKP AS+G A I+ Y +E R KW S+ E I+ +K
Sbjct: 30829 GKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVK 30887
Query: 205 GLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPE 240
L Y+F V+ N G S W S+I + P+
Sbjct: 30888 NLIEGLEYEFRVKCENLGGES--EW-SEISEPITPK 30920
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/215 (25%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 19 GPGAVSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGA 77
GP VS + P G P + + + ++W P+ GSPILGY + EV +
Sbjct: 14886 GPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREVNS 14945
Query: 78 ------DKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+KSL L + + L G Y + A + AG G+ S P
Sbjct: 14946 THWSRVNKSLLNALKAN------------VDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 14993
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
T + D PP P P V S + + L W+P A G I Y V+ ++
Sbjct: 14994 KT-AHDPISPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC 15051
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSP 226
+ I++ +K + +Y+ V A+N+ G P
Sbjct: 15052 TEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGP 15086
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/186 (25%), Positives = 80/186 (43%), Gaps = 11/186 (5%)
Query: 53 IQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRV 112
+ W P G PI Y + E ++ ++ V P T+ + DL G +Y
Sbjct: 17030 VTWNKPHDGGKPITNYILEKRE-----TMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 17084
Query: 113 SIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAP 172
++A ++ G G S P ++D P+ P P I + + V L+W+P +G +
Sbjct: 17085 RVSAENEIGIGDPSPPSK-PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSK 17143
Query: 173 IQYYSVEFIRPDFDKKWTSIH---ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRS 228
I Y VE+ + D++W + E + GL Y+F V A+N+ G S P
Sbjct: 17144 ILGYIVEYQKVG-DEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 17202
Query: 229 WPSDII 234
P ++
Sbjct: 17203 VPEPVL 17208
Score = 58.9 bits (141), Expect = 2e-08
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 15/217 (6%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTV 70
L L + G AV + +R GP D+K+ + T+ + W P + GS + Y V
Sbjct: 18678 LTLVNPAGEKAVFVN--VRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIV 18735
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG-RLSSPR 129
E AD+ ++ ++ T + +L PG EY + A ++ G G P+
Sbjct: 18736 EKRE--ADRKTWS-----TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPK 18788
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFD-KK 188
V L+ D P P++ V ++ + L+W P +G A I Y + + +
Sbjct: 18789 PV--LASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADR 18846
Query: 189 WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
WT + ++ S+V+ GL Y+F V A N+ G S
Sbjct: 18847 WTE-YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVS 18882
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/226 (26%), Positives = 95/226 (42%), Gaps = 20/226 (8%)
Query: 30 RKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSV 88
R PG G P+ + + S+ W P + G S + G+ V E + L +++++
Sbjct: 27755 RIPGPPGKPV---IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKE--RNSILWQKVNTS 27809
Query: 89 PLS-RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
P+S R+ T L G +Y+ + A + AG S P T + P P
Sbjct: 27810 PISGREYRAT-----GLVEGLDYQFRVYAENSAGLSSPSDPSKFTL----AVSPVDPPGT 27860
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH-ERIQMDSMVIKGL 206
P I V+ + L W P +G + I YS+E + +++W + + + GL
Sbjct: 27861 PDYIDVTRETITLKWNPPLRDGGSKIVGYSIE--KRQGNERWVRCNFTDVSECQYTVTGL 27918
Query: 207 DPDTNYQFAVRAMNSHGP-SPRSWPSDIIRTLCPEEAGSGRYGPRY 251
P Y+F + A N+ G SP S S II T +GP Y
Sbjct: 27919 SPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEY 27964
Score = 58.5 bits (140), Expect = 3e-08
Identities = 55/214 (25%), Positives = 96/214 (44%), Gaps = 13/214 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGAD 78
G S+ ++ + GPP + + + ++ WK P + GS I+ Y V E
Sbjct: 22623 GERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETS-- 22680
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
+L + ++ T + L G EY I A ++ G G V ++++
Sbjct: 22681 -----RLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPV--VAKNP 22733
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
+ P AP+ P V V+ + + W+ AS+G + I Y +E R +WT H+R+
Sbjct: 22734 FVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLE-KRDKEGIRWTRCHKRLIG 22792
Query: 199 D-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPS 231
+ + + GL + +Y+F V A N+ G S S PS
Sbjct: 22793 ELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPS 22826
Score = 58.5 bits (140), Expect = 3e-08
Identities = 54/236 (22%), Positives = 96/236 (40%), Gaps = 12/236 (5%)
Query: 2 DLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRH 60
D IR + +L S++G G S+ ++ + GPP +K+ + + W P
Sbjct: 24770 DCIRTDGGQYILKLSNVG-GTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQ 24828
Query: 61 PGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + + + +K +L +S ++ + L PG EY + A ++
Sbjct: 24829 DGGANISHYII------EKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 24882
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G G VT + PP P P V ++ + ++W +G I+ Y +E
Sbjct: 24883 GIGEPLESGPVTACNPYK--PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILE- 24939
Query: 181 IRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIR 235
R +WT +++ D + + GL +Y+F V A N+ G S PS R
Sbjct: 24940 KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 24995
Score = 58.2 bits (139), Expect = 4e-08
Identities = 59/212 (27%), Positives = 93/212 (43%), Gaps = 21/212 (9%)
Query: 36 GPPLDIKLGALNCTA--FSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
GPP + L+ T +I W+ P+ G SP++ Y V + D +S
Sbjct: 17605 GPPTG-PINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTW-------GVVSS 17656
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT-TLSQDSCLPPAAPQQPHVI 151
T+ I L+ G EY + A ++ G G P T T+++ PP+ P +P V
Sbjct: 17657 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVG---PPLDSTPTVAKHKFSPPSPPGKPVVT 17713
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDT 210
++++ +SW S+G +PI Y +E R + KW +++ D + GL
Sbjct: 17714 DITENAATVSWTLPKSDGGSPITGYYME--RREVTGKWVRVNKTPIADLKFRVTGLYEGN 17771
Query: 211 NYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V A N G PSP S P R + P
Sbjct: 17772 TYEFRVFAENLAGLSKPSPSSDPIKACRPIKP 17803
Score = 57.8 bits (138), Expect = 5e-08
Identities = 60/223 (26%), Positives = 94/223 (42%), Gaps = 19/223 (8%)
Query: 21 GAVSLRAAIRKPG-KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G +S++ + KPG GP IK + A +++W P+ G S I Y + +
Sbjct: 20066 GTISIKV-VGKPGIPTGP---IKFDEVTAEAMTLKWAPPKDDGGSEITNYIL-------E 20114
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQD 137
K V + + T + L G EY ++A ++ G G L S V D
Sbjct: 20115 KRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFD 20174
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
P AP P+++ V V+L+W G +PI Y +EF + W ++ I
Sbjct: 20175 V---PDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEF-KERNSLLWKRANKTPI 20230
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+M + GL Y+F V A+N G S PS+ + L P
Sbjct: 20231 RMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDP 20273
Score = 56.2 bits (134), Expect = 1e-07
Identities = 53/193 (27%), Positives = 85/193 (44%), Gaps = 14/193 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG G P+ + L + + + +QW P GS ++GY + E + L +L+ P
Sbjct: 22341 PGPPGTPV-VTLSSRD--SMEVQWNEPISDGGSRVIGYHLERKE--RNSILWVKLNKTP- 22394
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
IP T+ L+ G EY ++A + G G+ S +++D C PP P+
Sbjct: 22395 ---IPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECY-VARDPCDPPGRPE---A 22447
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
I+V+ + V L WK +G + I Y VE + + I + GL D
Sbjct: 22448 IIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDH 22507
Query: 211 NYQFAVRAMNSHG 223
Y+F V A N+ G
Sbjct: 22508 RYEFRVIARNAAG 22520
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/195 (26%), Positives = 84/195 (43%), Gaps = 13/195 (6%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQ-EQLHSVPL 90
G GPP ++ + ++ WK P G S I GY V E KSL+ + P+
Sbjct: 20570 GPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE---KKSLRWVRAIKTPV 20626
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
S D+ + L+ G+ Y ++A ++AG G S + L +D+ PP P PHV
Sbjct: 20627 S-DLRCK---VTGLQEGSTYEFRVSAENRAGIGPPSEASD-SVLMKDAAYPPGPPSNPHV 20681
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW--TSIHERIQMDSMVIKGLDP 208
+ +L+W +G I Y VE + D+ W + +++ V+ L
Sbjct: 20682 TDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVG-DEAWIKDTTGTALRITQFVVPDLQT 20740
Query: 209 DTNYQFAVRAMNSHG 223
Y F + A+N G
Sbjct: 20741 KEKYNFRISAINDAG 20755
Score = 55.5 bits (132), Expect = 3e-07
Identities = 55/211 (26%), Positives = 87/211 (41%), Gaps = 16/211 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG PP DI ++ A S+ W +P G S I Y V +V V
Sbjct: 18992 PGPPQPPFDIS--DIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDW-------VTA 19042
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQDSCLPPAAPQQPH 149
+ T +G L PG EY + A ++ G L+SP+ V +Q P+ P+
Sbjct: 19043 LASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMV---AQFPFGVPSEPKNAR 19099
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDP 208
V V+ + ++W S+G +PI Y +E + W ++ ++ GL
Sbjct: 19100 VTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN-SLLWVKANDTLVRSTEYPCAGLVE 19158
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
Y F + A+N G SP S P++ + P
Sbjct: 19159 GLEYSFRIYALNKAGSSPPSKPTEYVTARMP 19189
Score = 53.9 bits (128), Expect = 7e-07
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 15/201 (7%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLH 86
A+ G PP + ++ + + + W P G S I+ Y V + + ++
Sbjct: 21648 AVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCN-- 21705
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQ--DSCLPPAA 144
+ + + L G EY I A + AG +S+P + + D+ P
Sbjct: 21706 ----KKTLTDLRYKVSGLTEGHEYEFRIMAENAAG---ISAPSPTSPFYKACDTVFKPGP 21758
Query: 145 PQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMV 202
P P V+ S S ++++W +G + I Y VE P+ D +W + ++ S
Sbjct: 21759 PGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEED-EWQIVTPPAGLKATSYT 21817
Query: 203 IKGLDPDTNYQFAVRAMNSHG 223
I GL + Y+ + AMNS G
Sbjct: 21818 ITGLTENQEYKIRIYAMNSEG 21838
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/225 (25%), Positives = 96/225 (42%), Gaps = 17/225 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP L+++ + + ++ W +P GS I Y V E + +S ++
Sbjct: 20869 GPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREA------TRKSYSTATTKCH 20922
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T +V G L G EY + A ++ G G + S+ P+ P +++ ++
Sbjct: 20923 KCTYKVTG-LSEGCEYFFRVMAENEYGIGEPTETTEPVKASE----APSPPDSLNIMDIT 20977
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S V+L+W +G + I Y +E R D+ WT I ++ V++ L Y F
Sbjct: 20978 KSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQ-WTHI-TTVKGLECVVRNLTEGEEYTF 21035
Query: 215 AVRAMNSHGPS-PRSWPSDIIR--TLCPEEAGSGRYGPRYITDMG 256
V A+NS G S PR I++ T+ PE G Y I G
Sbjct: 21036 QVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 21080
Score = 52.8 bits (125), Expect = 2e-06
Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 11/200 (5%)
Query: 37 PPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ + ++W +P + GSPI Y V +V K Q + +
Sbjct: 14086 PPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRR-KGWQT------VDTTVK 14138
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T+ + L G+ Y +AA + G+ + + L++D+ P P V+ V+
Sbjct: 14139 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIED-SVLAKDTFTTPGPPYALAVVDVTK 14197
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQF 214
V L W+P ++G PIQ Y +E + +W + D + + + T QF
Sbjct: 14198 RHVDLKWEPPKNDGGRPIQRYVIE-KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQF 14256
Query: 215 AVRAMNSHGPSPRSWPSDII 234
VRA N G S P++I+
Sbjct: 14257 QVRAENEAGVGHPSEPTEIL 14276
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 18/194 (9%)
Query: 52 SIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RDIPTTEEVIGDLKPGTE 109
S+ W P+ G SPI GY + + E + L ++ + P+ RD T L G E
Sbjct: 20193 SLTWTDPKKTGGSPITGYHLEFKE--RNSLLWKRANKTPIRMRDFKVT-----GLTEGLE 20245
Query: 110 YRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEG 169
Y + A + AG G+ S P ++ D PP +P VI ++ + V L W +G
Sbjct: 20246 YEFRVMAINLAGVGKPSLPSE-PVVALDPIDPPG---KPEVINITRNSVTLIWTEPKYDG 20301
Query: 170 SAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+ Y VE R K W H + + + L Y+F +RA N+ G S
Sbjct: 20302 GHKLTGYIVE-KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAI--S 20358
Query: 229 WPSDIIRT-LCPEE 241
PS+ T +C +E
Sbjct: 20359 APSESTETIICKDE 20372
Score = 52.0 bits (123), Expect = 3e-06
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 14/182 (7%)
Query: 46 LNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDL 104
++ A SI+W+ P H G S I+GY V E ++E + VP + +V G L
Sbjct: 28852 VSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKE--NKVPC---LECNYKVTG-L 28905
Query: 105 KPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKP 164
G EY+ A + AG + S ++Q+ P AP +P V V+ S V+L W
Sbjct: 28906 VEGLEYQFRTYALNAAGVSKASEASR-PIMAQN---PVDAPGRPEVTDVTRSTVSLIWSA 28961
Query: 165 GASEGSAPIQYYSVEF--IRPDFDKKWTSIHERIQMDS-MVIKGLDPDTNYQFAVRAMNS 221
A +G + + Y +E + D +W + I D+ + L Y+F V A N+
Sbjct: 28962 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNA 29021
Query: 222 HG 223
G
Sbjct: 29022 AG 29023
Score = 52.0 bits (123), Expect = 3e-06
Identities = 53/221 (23%), Positives = 85/221 (38%), Gaps = 23/221 (10%)
Query: 19 GPGA------VSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
GPG + R + P G P ++ G + IQW P G + I Y V
Sbjct: 29221 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHII---IQWTKPESDGGNEISNYLV- 29276
Query: 72 YSEVGADKSLQEQLHSVPLSRD--IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
DK ++ L +++D + T + L G +Y+ + A + AG S
Sbjct: 29277 ------DKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEAS 29330
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ + + S P P P V+ + ++L+W +G I Y +E D D +W
Sbjct: 29331 NFISCREPS-YTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTD-QW 29388
Query: 190 TSIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+H I+ + L Y F V A+N G S S
Sbjct: 29389 YRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYS 29429
Score = 51.2 bits (121), Expect = 5e-06
Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 18/199 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+++ + ++ + + W+ P GSPI+ Y V K E+ ++ +
Sbjct: 19788 GPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV-------QKRDAERKSWSTVTTEC 19840
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + +L+ G Y + A ++ G G R SQ P V VS
Sbjct: 19841 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQT----PGPVVDLKVRSVS 19896
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S ++ WK S+G + I Y V+F+ + KW + + + + K L Y F
Sbjct: 19897 KSSCSIGWKKPHSDGGSRIIGYVVDFLTE--ENKWQRVMKSLSLQYSA-KDLTEGKEYTF 19953
Query: 215 AVRAMNSHGPSPRSWPSDI 233
V A N +G PS+I
Sbjct: 19954 RVSAENENG---EGTPSEI 19969
Score = 51.2 bits (121), Expect = 5e-06
Identities = 50/188 (26%), Positives = 80/188 (42%), Gaps = 13/188 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP K+ + + W++P + G S ++GY + Y E L + + + ++
Sbjct: 25588 GPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKE--RSSILWSKANKILIA--- 25642
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T+ + L G Y + A + AG G+ S ++D C PP QP V ++
Sbjct: 25643 -DTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDPPG---QPEVTNIT 25697
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQ 213
V+L W +G A I Y VE R D +W + IQ + L D Y+
Sbjct: 25698 RKSVSLKWSKPHYDGGAKITGYIVE-RRELPDGRWLKCNYTNIQETYFEVTELTEDQRYE 25756
Query: 214 FAVRAMNS 221
F V A N+
Sbjct: 25757 FRVFARNA 25764
Score = 51.2 bits (121), Expect = 5e-06
Identities = 74/330 (22%), Positives = 123/330 (37%), Gaps = 27/330 (8%)
Query: 11 LLLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYT 69
+L L + G +V++ + KPG PL+I L S+ W P+ G + Y
Sbjct: 25861 VLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN--GLTAEKCSLSWGRPQEDGGADIDYY 25918
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
+ +K L ++ T + L G EY + ++ G G
Sbjct: 25919 I------VEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESV 25972
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D P+ P + V+ + L W S+G + I Y +E R +W
Sbjct: 25973 AIKAL--DPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIE-RREKNSLRW 26029
Query: 190 TSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
++++ D V GL Y++ V A N+ G S S S +IR P S
Sbjct: 26030 VRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSK 26089
Query: 249 PRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
P+ + D I+ VKPL + VE KK ++ KT +
Sbjct: 26090 PKIV-------------DSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQS 26136
Query: 309 IPPTSASLP-VTTVAPQPIPIQRKGKNGVA 337
+ T ++ +TT A ++ K G +
Sbjct: 26137 LRGTEYTISGLTTGAEYVFRVKSVNKVGAS 26166
Score = 50.4 bits (119), Expect = 8e-06
Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 10/112 (8%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K PP++ + C + + W+ PRH GS ILGY V Y +VG D+ + H+
Sbjct: 17112 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVG-DEEWRRANHT---PE 17167
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV--TTLSQDSCLPP 142
P T+ + L+ G Y+ + A + AG+ S P HV L +D PP
Sbjct: 17168 SCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKDRLEPP 17216
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/207 (24%), Positives = 84/207 (40%), Gaps = 15/207 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PGKV P I+ + ++ W P + G +PI Y + +K +L +
Sbjct: 28052 PGKVVGP--IRFTNITGEKMTLWWDAPLNDGCAPITHYII-------EKRETSRLAWALI 28102
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
L G EY+ ++A ++ G GR V ++Q P AP P
Sbjct: 28103 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPV--VAQIQYTVPDAPGIPEP 28160
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDP 208
++ + + L+W S+G + IQ Y +E R +W + + I + GL
Sbjct: 28161 SNITGNSITLTWARPESDGGSEIQQYILE-RREKKSTRWVKVISKRPISETRFKVTGLTE 28219
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIR 235
Y+F V A N+ G P S S +I+
Sbjct: 28220 GNEYEFHVMAENAAGVGPASGISRLIK 28246
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/244 (21%), Positives = 98/244 (40%), Gaps = 15/244 (6%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L + ++ G AVS+ + PG G ++ CT + W +P+ G + + +
Sbjct: 29120 LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCT---LAWSLPQEDGGAEITHYI 29176
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
++ +L+ V + + PT V+ L EY + A ++ G G
Sbjct: 29177 ------VERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEP 29230
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
+ ++++S P+ P P + + + W S+G I Y V+ R +WT
Sbjct: 29231 I--VARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDK-REKKSLRWT 29287
Query: 191 SIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
+++ + + + L +YQF V A+N+ G S S S+ I P
Sbjct: 29288 RVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSA 29347
Query: 249 PRYI 252
PR +
Sbjct: 29348 PRVV 29351
Score = 49.3 bits (116), Expect = 2e-05
Identities = 56/219 (25%), Positives = 86/219 (39%), Gaps = 21/219 (9%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G S +R PP+++K+ + + SI W+ P GS I Y V +K
Sbjct: 23020 GTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIV-------EK 23072
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ + + I L+ G Y + A ++ G G + + D
Sbjct: 23073 REATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG-------LPAQTADPI 23125
Query: 140 LPPAAPQQPHVIVVSD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERI 196
PQ P I V D + V+LSW +G + I Y VE ++ +KW+ R+
Sbjct: 23126 KVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVE-MQAKHSEKWSEC-ARV 23183
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
+ VI L Y F V A+N G S PRS I+
Sbjct: 23184 KSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIV 23222
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/216 (25%), Positives = 88/216 (40%), Gaps = 15/216 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G+ S +R GPP D+K+ + T+ ++ W P GS I Y V +K
Sbjct: 21938 GSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIV-------EK 21990
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ ++ + T + L+ G Y + A ++ G G + T S +
Sbjct: 21991 RESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE----TAESVKAS 22046
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
P P + ++ V+ + V+LSW+ +G + I Y VE D KW + +++
Sbjct: 22047 ERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSD-KWATC-ATVKVT 22104
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
I GL Y F V A N G S PR +I
Sbjct: 22105 EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 22140
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/192 (22%), Positives = 81/192 (42%), Gaps = 13/192 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RD 93
GPP +++ + + ++ W P G S I+GY V +K + + + + R
Sbjct: 23820 GPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIV-------EKRDRSGIRWIKCNKRR 23872
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
I + L EY ++A + AG G SP V + D P P H++
Sbjct: 23873 ITDLRLRVTGLTEDHEYEFRVSAENAAGVGE-PSPATVYYKACDPVFKPGPPTNAHIVDT 23931
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTN 211
+ + + L+W +G + I Y VE + D +++W + + +++ I L
Sbjct: 23932 TKNSITLAWGKPIYDGGSEILGYVVEICKAD-EEEWQIVTPQTGLRVTRFEISKLTEHQE 23990
Query: 212 YQFAVRAMNSHG 223
Y+ V A+N G
Sbjct: 23991 YKIRVCALNKVG 24002
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/206 (22%), Positives = 87/206 (42%), Gaps = 14/206 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADK 79
G+ S ++ GPP ++ + + + + W+ P G+ + Y + DK
Sbjct: 24102 GSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVI-------DK 24154
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ +S T + +L G Y + A ++ G G T + +
Sbjct: 24155 RESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVE----TVDAVKAA 24210
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
PP+ P + + VS + +L W+ +G + + Y VE ++P +KW+ + E ++
Sbjct: 24211 EPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVE-MQPKGTEKWSIVAES-KVC 24268
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ V+ GL YQF V+A N G S
Sbjct: 24269 NAVVTGLSSGQEYQFRVKAYNEKGKS 24294
Score = 48.1 bits (113), Expect = 4e-05
Identities = 59/239 (24%), Positives = 93/239 (38%), Gaps = 28/239 (11%)
Query: 16 SSLGPGAVSLRAAIRKPGKV---------GPPLD-IKLGALNCTAFSIQWKMPRHPGS-P 64
S GP ++ R + + G V GPP IK ++ + W P + G P
Sbjct: 21131 SDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 21190
Query: 65 ILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR 124
I Y V + + V L+ + T L G EY+ + A ++ G G
Sbjct: 21191 ISNYVVEMRQT-------DSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGP 21243
Query: 125 LSSPRHVTTLSQDSCLP---PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFI 181
+T+ + P P P P V V+ + +SW S+G +PI Y VE
Sbjct: 21244 -----GITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVE-R 21297
Query: 182 RPDFDKKWTSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ W ++ + + ++ GL Y+F V A N G S S PS+ + L P
Sbjct: 21298 KERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDP 21356
Score = 47.8 bits (112), Expect = 5e-05
Identities = 47/200 (23%), Positives = 77/200 (38%), Gaps = 13/200 (6%)
Query: 32 PGKVGPP-LDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVP 89
PG VG P L L +C + W P G SPI Y + +K ++ P
Sbjct: 16616 PGPVGTPFLAHNLTNESC---KLTWFSPEDDGGSPITNYVI-------EKRESDRRAWTP 16665
Query: 90 LSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPH 149
++ + + L G Y IAA + G G + + +P P+
Sbjct: 16666 VTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPER-PEDLE 16724
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPD 209
V V+ + V L+W P +G + I Y +E +K ++ + +KGL
Sbjct: 16725 VKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEG 16784
Query: 210 TNYQFAVRAMNSHGPSPRSW 229
Y++ V A+N G S+
Sbjct: 16785 DTYEYRVSAVNIVGQGKPSF 16804
Score = 47.4 bits (111), Expect = 7e-05
Identities = 52/207 (25%), Positives = 87/207 (42%), Gaps = 27/207 (13%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP++ + T+ +W+ P G S I+ YT L+++ + P S I
Sbjct: 14803 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYT-----------LEKKDKTKPDSEWI 14851
Query: 95 PTTEEV------IGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQDSCLPPAAPQ 146
T + + L G EY + A ++ G G +S P +++D PP AP
Sbjct: 14852 VVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP----LVAKDPFGPPDAPD 14907
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKG 205
+P V V+ + + + W GS + Y+ + R W+ +++ + + G
Sbjct: 14908 KPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEK--REVNSTHWSRVNKSLLNALKANVDG 14965
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSD 232
L Y F V A N+ GP S PSD
Sbjct: 14966 LLEGLTYVFRVCAENAAGPGKFSPPSD 14992
Score = 47.4 bits (111), Expect = 7e-05
Identities = 49/189 (25%), Positives = 78/189 (41%), Gaps = 13/189 (6%)
Query: 50 AFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGT 108
A ++ W +P+ G SPI GY + EV +++ P++ + + L G
Sbjct: 17719 AATVSWTLPKSDGGSPITGYYMERREVTGK---WVRVNKTPIA----DLKFRVTGLYEGN 17771
Query: 109 EYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASE 168
Y + A + AG + SP + PP P P + S L W S+
Sbjct: 17772 TYEFRVFAENLAGLSK-PSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSD 17830
Query: 169 GSAPIQYYSVEFIRPDFDKKWTSIH--ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGP-S 225
G +PI Y VE +P +W I+ E I+ + + GL Y+F ++A N G
Sbjct: 17831 GGSPILGYVVECQKPG-TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 17889
Query: 226 PRSWPSDII 234
PR +I
Sbjct: 17890 PRELAESVI 17898
Score = 47.4 bits (111), Expect = 7e-05
Identities = 51/219 (23%), Positives = 90/219 (41%), Gaps = 14/219 (6%)
Query: 13 LLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVF 71
+L +S G+ S ++ + GPP +++ + S+ W P G + + V
Sbjct: 23697 ILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYV- 23755
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+K +L ++ ++ T + L G EY I A ++ G G V
Sbjct: 23756 -----VEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPV 23810
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
L ++ + P P+ V ++ + + W S+G + I Y VE R +W
Sbjct: 23811 --LMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVE-KRDRSGIRWIK 23867
Query: 192 IHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHG---PSP 226
++R D + + GL D Y+F V A N+ G PSP
Sbjct: 23868 CNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSP 23906
Score = 47.0 bits (110), Expect = 9e-05
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 26/264 (9%)
Query: 22 AVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKS 80
A SL ++ GPP +I + + + + W +P + G+P+ Y + +K
Sbjct: 26265 AASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHI-------EKR 26317
Query: 81 LQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCL 140
+ V ++ + + +L+ G Y ++ ++ G G + + +++
Sbjct: 26318 EASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE---- 26373
Query: 141 PPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P+ P++ V +S V+L+W +G + I +Y VE + K W +
Sbjct: 26374 KPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKG-QKNWVKC-AVAKSTH 26431
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS-PRS--WPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ GL ++ Y F V A N G S PR P I L P E + P + + A
Sbjct: 26432 HVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNF-PSHTVYVRA 26490
Query: 258 GEDDEGFEDDLDLDISFEEVKPLP 281
G +L +DI KPLP
Sbjct: 26491 G-------SNLKVDIPISG-KPLP 26506
Score = 46.2 bits (108), Expect = 2e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 17/214 (7%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
L +S G +L + K GPP +K+ + + ++ W P++ G S I Y V
Sbjct: 22222 LTNSAGEAIETLNVIVLD--KPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIV- 22278
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
E + Q+ S ++R TT + LK G EY+ IAA ++ GK +
Sbjct: 22279 --EKRDTSTTTWQIVSATVAR---TTIKACR-LKTGCEYQFRIAAENRYGKSTYLNSE-- 22330
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWT 190
T++Q P P P V + S + + W S+G + + Y +E R + + W
Sbjct: 22331 PTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLE--RKERNSILWV 22388
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
+++ I GL+ Y+F V A N G
Sbjct: 22389 KLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVG 22422
Score = 46.2 bits (108), Expect = 2e-04
Identities = 49/192 (25%), Positives = 76/192 (39%), Gaps = 11/192 (5%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP+ ++ ++ I W+ P + G G + V + H V S
Sbjct: 24404 KPGPPVGPVRFDEVSADFVVISWEPPAYTG----GCQISNYIVEKRDTTTTTWHMV--SA 24457
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T I LK GTEY+ I A ++ GK + V + Q P P P V
Sbjct: 24458 TVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAV--IVQYPFKEPGPPGTPFVTS 24515
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTN 211
+S ++ + W ++G I Y +E + W +++ IQ GLD
Sbjct: 24516 ISKDQMLVQWHEPVNDGGTKIIGYHLE-QKEKNSILWVKLNKTPIQDTKFKTTGLDEGLE 24574
Query: 212 YQFAVRAMNSHG 223
Y+F V A N G
Sbjct: 24575 YEFKVSAENIVG 24586
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP I++ ++ ++ W P + G S + GY V + +E+ +V ++
Sbjct: 27168 GPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQ-----GEEEEWTTVSTKGEV 27222
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
TTE V+ +LKPG Y ++A + AG+G
Sbjct: 27223 RTTEYVVSNLKPGVNYYFRVSAVNCAGQG 27251
Score = 45.8 bits (107), Expect = 2e-04
Identities = 32/118 (27%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 26 RAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQ 84
R A++ GP +D+K+ +++ ++ SI WK P GS I+GY V + + + Q
Sbjct: 19875 RDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDF--LTEENKWQRV 19932
Query: 85 LHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
+ S+ L DL G EY ++A ++ G+G +P +T +++D + P
Sbjct: 19933 MKSLSLQYSAK-------DLTEGKEYTFRVSAENENGEG---TPSEITVVARDDVVAP 19980
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + +SW P ++G + + +Y VE D K W+++ ++ S + L P Y
Sbjct: 18710 VTKTSCHVSWAPPENDGGSQVTHYIVEKREAD-RKTWSTVTPEVKKTSFHVTNLVPGNEY 18768
Query: 213 QFAVRAMNSHGPS-PRSWPSDII 234
F V A+N +GP P P ++
Sbjct: 18769 YFRVTAVNEYGPGVPTDVPKPVL 18791
Score = 43.9 bits (102), Expect = 8e-04
Identities = 60/208 (28%), Positives = 84/208 (40%), Gaps = 30/208 (14%)
Query: 36 GPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRD 93
GPP+ + + I WK P G S I Y + EVG D + P++
Sbjct: 16913 GPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWM-------PVTSA 16965
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL-SQDSCLPPAAPQQPHVIV 152
T + L G +Y I A + G +S P ++ ++D P AP QP V
Sbjct: 16966 SAKTTCKVSKLLEGKDYIFRIHAENLYG---ISDPLVSDSMKAKDRFRVPDAPDQPIVTE 17022
Query: 153 VSDSEVALSW-KPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM--VIKGLDPD 209
V+ ++W KP +G PI Y +E R K+W R+ D + K PD
Sbjct: 17023 VTKDSALVTWNKP--HDGGKPITNYILE-KRETMSKRWA----RVTKDPIHPYTKFRVPD 17075
Query: 210 ----TNYQFAVRAMNSHG---PSPRSWP 230
Y+F V A N G PSP S P
Sbjct: 17076 LLEGCQYEFRVSAENEIGIGDPSPPSKP 17103
Score = 43.9 bits (102), Expect = 8e-04
Identities = 56/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)
Query: 38 PLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P+++ + + + ++ W+ P G+ I Y V +K + ++ +
Sbjct: 25202 PVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIV-------EKRETTRKAYATITNNCTK 25254
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDS 156
T I +L+ G Y + A ++ G G + +S+ PP P + ++ V+ +
Sbjct: 25255 TTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE----PPLPPGRVTLVDVTRN 25310
Query: 157 EVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAV 216
+ W+ S+G + I Y VE ++ +KW++ +++ I GL Y F V
Sbjct: 25311 TATIKWEKPESDGGSKITGYVVE-MQTKGSEKWSTC-TQVKTLEATISGLTAGEEYVFRV 25368
Query: 217 RAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFE 275
A+N G S PR +I E P + ++ A E L +D+ F+
Sbjct: 25369 AAVNEKGRSDPRQLGVPVIAR--DIEIKPSVELPFHTFNVKARE-------QLKIDVPFK 25419
Query: 276 EVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
+ + L E+ ++++S+ KT++ L
Sbjct: 25420 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSL 25452
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 14/119 (11%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLH 86
A++ PP + L ++ T+ S+ W+ P H GS +LGY V G +K
Sbjct: 24206 AVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEK------- 24258
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR--HVTTLSQDSCLPPA 143
+ + V+ L G EY+ + AY++ GK S PR V +++D + P+
Sbjct: 24259 -WSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGK---SDPRVLGVPVIAKDLTIQPS 24313
Score = 43.5 bits (101), Expect = 0.001
Identities = 51/217 (23%), Positives = 97/217 (44%), Gaps = 16/217 (7%)
Query: 29 IRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHS 87
I +PG V P+++ +++ + + W P+ G + I Y V E G + QL
Sbjct: 28738 IGRPGPVTGPIEVS--SVSAESCVLSWGEPKDGGGTEITNYIVEKRESG---TTAWQL-- 28790
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQ 146
++ + T+ + L EY +++ ++ G +S P +++ +PP+AP
Sbjct: 28791 --VNSSVKRTQIKVTHLTKYMEYSFRVSSENRFG---VSKPLESAPIIAEHPFVPPSAPT 28845
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKG 205
+P V VS + +++ W+ +G + I Y VE + W ++ ++ + + G
Sbjct: 28846 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTG 28904
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
L YQF A+N+ G S S S I P +A
Sbjct: 28905 LVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDA 28941
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/103 (30%), Positives = 42/103 (40%), Gaps = 7/103 (6%)
Query: 124 RLSSPRHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIR 182
R++ P V TL PP+ P+ P + V LSW G I YS+E R
Sbjct: 27644 RIAVPITVITLG-----PPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEK-R 27697
Query: 183 PDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
W + + + + L D YQF VRA N +G S
Sbjct: 27698 ETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 27740
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/217 (24%), Positives = 81/217 (37%), Gaps = 28/217 (12%)
Query: 27 AAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP----ILG--YTVFYSEVGADKS 80
+A+ K G VG PLD + IQ+ +P PG P I G T+ ++ +D
Sbjct: 28127 SAVNKFG-VGRPLDS-----DPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGG 28180
Query: 81 LQEQLH-------------SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSS 127
+ Q + V R I T + L G EY + A + AG G S
Sbjct: 28181 SEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASG 28240
Query: 128 PRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
+ ++ PP P V S + V+L W +G I Y +E + D
Sbjct: 28241 ISRLIKC-REPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLG- 28298
Query: 188 KWTSIH-ERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
W ++ E + L Y+F V A+N G
Sbjct: 28299 DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 28335
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P+ P + V+ + LSW P +G A I +Y V+ R WT++ +Q+
Sbjct: 21555 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQK-RETSRLAWTNVASEVQVTK 21613
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ + L Y F V A+N +G
Sbjct: 21614 LKVTKLLKGNEYIFRVMAVNKYG 21636
Score = 42.0 bits (97), Expect = 0.003
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 14/199 (7%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
P +K ++ + ++ W P + G I Y V + + V +S +
Sbjct: 23326 PKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIV------QKRDTTTTVWDV-VSATVA 23378
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + LK GTEY+ I A ++ G+ + ++Q P P P +S
Sbjct: 23379 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI--VAQYPYKEPGPPGTPFATAISK 23436
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWTSIHERIQMDSMV-IKGLDPDTNYQ 213
+ + W + G +P+ Y +E R + + WT +++ I D+ + L+ Y+
Sbjct: 23437 DSMVIQWHEPVNNGGSPVIGYHLE--RKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYE 23494
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V A N G S S+
Sbjct: 23495 FRVYAENIVGVGKASKNSE 23513
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/101 (28%), Positives = 42/101 (41%), Gaps = 1/101 (0%)
Query: 142 PAAPQQPHVI-VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI + + +SWKP A +G + I Y VE +W + I + +
Sbjct: 30723 PDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTT 30782
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
I L + Y F V A N+ G S S ++ P E
Sbjct: 30783 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFE 30823
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 23/190 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+ ++ + T ++W+ P + G I+GY V VG ++ S + I
Sbjct: 15004 GPPIP-RVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNE------WSRCTEKMI 15056
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ + +++ G +Y++ ++A + AG+G + VT A PQ+P +
Sbjct: 15057 KVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV---------AEPQEPPAV--- 15104
Query: 155 DSEVALSWKPGAS-EGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
E+ +S K G ++ +V RP K WT + D +VI + +
Sbjct: 15105 --ELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELI 15162
Query: 214 FAVRAMNSHG 223
HG
Sbjct: 15163 IKDALRKDHG 15172
Score = 40.0 bits (92), Expect = 0.011
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 1/98 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP++ ++ V L+W+P +G +P+ Y VE R K WT + + +
Sbjct: 13488 PSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVE-KREVSRKTWTKVMDFVTDLEF 13546
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ L Y F V A N GP ++ + + P
Sbjct: 13547 TVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTP 13584
Score = 40.0 bits (92), Expect = 0.011
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P P + VS + L+W P +G +PI+ Y +E R WT + E IQ
Sbjct: 20473 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILE-KRETSRLLWTVVSEDIQSCRH 20531
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
V L Y F V A+N +G
Sbjct: 20532 VATKLIQGNEYIFRVSAVNHYG 20553
Score = 39.3 bits (90), Expect = 0.019
Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 8/140 (5%)
Query: 92 RDIPTTEEVIGDLKP-GTEYRVSIAAYSQAGKGRLS--SPRHVTTLSQDSCL--PPAAPQ 146
RD PT + D+ P G++ + AA+ G L+ +P T+S + P P+
Sbjct: 17257 RDAPTKARI--DVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPR 17314
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGL 206
V + L+WK +G + I Y VE R +W+ + + S K L
Sbjct: 17315 DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER-RDVASAQWSPLSATSKKKSHFAKHL 17373
Query: 207 DPDTNYQFAVRAMNSHGPSP 226
+ Y F V A N +G P
Sbjct: 17374 NEGNQYLFRVAAENQYGRGP 17393
Score = 39.3 bits (90), Expect = 0.019
Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 9/112 (8%)
Query: 15 ASSLGPGA-VSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVF 71
A+ +GP + +S R+P GPP +K+ + T S++W P G I+GY +
Sbjct: 28232 AAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIE 28291
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
+ H V + T V DL+ G EY+ ++A + AGKG
Sbjct: 28292 MCKADLG-----DWHKVNAEACVKTRYTVT-DLQAGEEYKFRVSAINGAGKG 28337
Score = 38.9 bits (89), Expect = 0.025
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP + V V LSW+P +G A I Y VE R K + +I +
Sbjct: 25199 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE-KRETTRKAYATITNNCTKTTF 25257
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
I+ L +Y F V A N +G
Sbjct: 25258 RIENLQEGCSYYFRVLASNEYG 25279
Score = 38.9 bits (89), Expect = 0.025
Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 14/158 (8%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + L+W +G A I +Y VE R W + S V+ L + Y
Sbjct: 29152 VTQEKCTLAWSLPQEDGGAEITHYIVER-RETSRLNWVIVEGECPTLSYVVTRLIKNNEY 29210
Query: 213 QFAVRAMNSHGPSPRSWPSDIIRTL---------CPEEAGSGRYGPRYITDMGAGEDDEG 263
F VRA+N +GP I+ PEE G+G+ +I + +G
Sbjct: 29211 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK---EHIIIQWTKPESDG 29267
Query: 264 FEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISN 301
+ + + E K L T+ NK ++V ++ +++
Sbjct: 29268 GNEISNYLVDKREKKSLRWTR-VNKDYVVYDTRLKVTS 29304
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/100 (33%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
T+ D P P+ V VS V L+W AS+G + I Y VE + +W +
Sbjct: 31113 TVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRV 31171
Query: 193 HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + VI L T+YQF V A N G S S PS+
Sbjct: 31172 GQARETRYTVI-NLFGKTSYQFRVIAENKFGLSKPSEPSE 31210
Score = 37.7 bits (86), Expect = 0.055
Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 2/85 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI +++ V L W+P +G + + Y + R WT + +
Sbjct: 26570 PGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY-ILLKRETSTAVWTEVSATVARTM 26628
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS 225
M + L YQF ++A N G S
Sbjct: 26629 MKVMKLTTGEEYQFRIKAENRFGIS 26653
Score = 37.0 bits (84), Expect = 0.094
Identities = 36/171 (21%), Positives = 69/171 (40%), Gaps = 17/171 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP + ++ + ++ W P + G +PI+GY V AD S E + +
Sbjct: 18498 GPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 18557
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
E + L EY + A +Q G GR + +++ P + P + + +
Sbjct: 18558 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAE-------LKEAIKPKEILEPPEIDLDA 18610
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKG 205
+ + G PI+ +++ RP W ++ +D++V KG
Sbjct: 18611 SMRKLVIVRAG-----CPIRLFAIVRGRPAPKVTW----RKVGIDNVVRKG 18652
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDS 200
P P V +S ++W+P +G +PI Y V+ + D ++K W+++ S
Sbjct: 19787 PGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ--KRDAERKSWSTVTTECSKTS 19844
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ L+ +Y F V A N +G
Sbjct: 19845 FRVANLEEGKSYFFRVFAENEYG 19867
Score = 36.6 bits (83), Expect = 0.12
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
PAA Q+ V VS V L W P +G +PI Y +E R + W+ + + S
Sbjct: 27366 PAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE-KRDATKRTWSVVSHKCSSTSF 27424
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
+ L T + F V A N G
Sbjct: 27425 KLIDLSEKTPFFFRVLAENEIG 27446
Score = 34.3 bits (77), Expect = 0.61
Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 2/88 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ L W +G A I +Y VE R + W I E+ + L Y
Sbjct: 28460 VTRGSATLMWDAPLLDGGARIHHYVVEK-REASRRSWQVISEKCTRQIFKVNDLAEGVPY 28518
Query: 213 QFAVRAMNSHG-PSPRSWPSDIIRTLCP 239
F V A+N +G P P I+ T P
Sbjct: 28519 YFRVSAVNEYGVGEPYEMPEPIVATEQP 28546
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/142 (28%), Positives = 57/142 (40%), Gaps = 16/142 (11%)
Query: 89 PLS-RDIPTTEEV----IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPA 143
PLS + I TT E I + K G + R I ++ GK V + P
Sbjct: 13039 PLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDV-------PG 13091
Query: 144 APQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDSMV 202
+ V D EV+L+W+ ++G + I Y VE R D +K W +R +
Sbjct: 13092 PVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVE--RRDIKRKTWVLATDRAESCEFT 13149
Query: 203 IKGLDP-DTNYQFAVRAMNSHG 223
+ GL Y F V A N G
Sbjct: 13150 VTGLQKGGVEYLFRVSARNRVG 13171
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 11/197 (5%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQ-LHSVPLSR 92
+V P + ++L T ++ P H + + G + E ++++ E+ ++ +++
Sbjct: 15392 EVPPTIKLRLSVRGDT-IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 15450
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQQPHVI 151
+ + E +L R Y+ RL S R+V D P+ P+ V
Sbjct: 15451 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDR---PSPPRNLAVT 15507
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK---WTSIHERIQMDSMVIKGLDP 208
+ L+W G + I +Y ++ + D +K W + I L P
Sbjct: 15508 DIKAESCYLTWDAPLDNGGSEITHYVID--KRDASRKKAEWEEVTNTAVEKRYGIWKLIP 15565
Query: 209 DTNYQFAVRAMNSHGPS 225
+ Y+F VRA+N +G S
Sbjct: 15566 NGQYEFRVRAVNKYGIS 15582
Score = 32.0 bits (71), Expect = 3.0
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
V L +D+P E I + + I+A + +G + S+ +V P Q
Sbjct: 17955 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR-------PGPCQN 18007
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLD 207
V V+ +SW+ G + I + VE+ +P+ K W+ + + ++ L
Sbjct: 18008 LKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPN-QKGWSIVASDV-TKRLIKANLL 18065
Query: 208 PDTNYQFAVRAMNSHGPSP 226
+ Y F V A N G P
Sbjct: 18066 ANNEYYFRVCAENKVGVGP 18084
Score = 31.2 bits (69), Expect = 5.1
Identities = 21/93 (22%), Positives = 33/93 (35%), Gaps = 1/93 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P + ++ VS + W P +G IQ Y +E W++ +
Sbjct: 18297 PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETK-RMVWSTYSATVLTPGT 18355
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDII 234
+ L Y F VRA N G P + +I
Sbjct: 18356 TVTRLIEGNEYIFRVRAENKIGTGPPTESKPVI 18388
Score = 30.4 bits (67), Expect = 8.8
Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 8/124 (6%)
Query: 111 RVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGS 170
+ +I A +Q+GK + T L + P P V VS V ++W+ +G
Sbjct: 29514 KYTIEAENQSGK------KSATVLVKVYDTPGPCPSVK-VKEVSRDSVTITWEIPTIDGG 29566
Query: 171 APIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWP 230
AP+ Y VE R + + ++ + I GL T Y F V N +G
Sbjct: 29567 APVNNYIVE-KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCET 29625
Query: 231 SDII 234
SD +
Sbjct: 29626 SDAV 29629
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 81.3 bits (199), Expect = 4e-15
Identities = 65/205 (31%), Positives = 94/205 (45%), Gaps = 17/205 (8%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG+ PP+ + + ++ WK P G SPI GY + E A + + +
Sbjct: 13183 PGRCDPPV---ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPI-I 13238
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
R + T L+ GTEY + A ++AG G+ S ++D PP P P V
Sbjct: 13239 ERTLKAT-----GLQEGTEYEFRVTAINKAGPGKPSDASKAA-YARDPQYPPGPPAFPKV 13292
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT--SIHERIQMDSMVIKGLDP 208
+ S V+LSW A +G +PI Y VE R D D W ++ + +Q + GL
Sbjct: 13293 YDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSD-NWVRCNLPQNLQKTRFEVTGLME 13351
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDI 233
DT YQF V A+N G S PSD+
Sbjct: 13352 DTQYQFRVYAVNKIGYSD---PSDV 13373
Score = 77.0 bits (188), Expect = 8e-14
Identities = 64/207 (30%), Positives = 96/207 (46%), Gaps = 11/207 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + A ++ W P G SPI GY V + DK ++ + +P+
Sbjct: 7579 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR--CNKMPVK--- 7633
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
TT V G L +YR + A + AG G+ S L +D PP P +P V V
Sbjct: 7634 DTTYRVKG-LTNKKKYRFRVLAENLAGPGKPSKSTE-PILIKDPIDPPWPPGKPTVKDVG 7691
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
+ V L+W +G A I+ Y +E ++ D +W + E + ++ GL Y F
Sbjct: 7692 KTSVRLNWTKPEHDGGAKIESYVIEMLKTGTD-EWVRVAEGVPTTQHLLPGLMEGQEYSF 7750
Query: 215 AVRAMNSHGPSPRSWPSDIIRTLCPEE 241
VRA+N G S S PSD + LC E+
Sbjct: 7751 RVRAVNKAGESEPSEPSDPV--LCREK 7775
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/213 (26%), Positives = 94/213 (44%), Gaps = 13/213 (6%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFY 72
+ S L + R++IR PG PP +++ ++ ++ W P G S + GY V
Sbjct: 23609 IGSYLQSEVIECRSSIRIPG---PPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVER 23665
Query: 73 SEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT 132
EV AD+ ++ V ++R T L G EY + A + G G+ S P
Sbjct: 23666 KEVRADRWVRVNKVPVTMTRYRST------GLTEGLEYEHRVTAINARGSGKPSRPSK-P 23718
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
++ D PP PQ P V + + V+L+W EG + + Y +E + D +WT
Sbjct: 23719 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVD-QHEWTKC 23777
Query: 193 HER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGP 224
+ ++ + L Y+F V A N+ GP
Sbjct: 23778 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGP 23810
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/207 (28%), Positives = 92/207 (44%), Gaps = 26/207 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSE------VGADKSLQEQLHSV 88
GPP + + + ++W+ P++ G PI Y + E V A K+
Sbjct: 7880 GPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAG------ 7933
Query: 89 PLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
P + D+ GTE + + A ++AG G S P + ++ +D PP+ P
Sbjct: 7934 ------PDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI-EDPTSPPSPPLDL 7986
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD--SMVIKGL 206
HV +A++WKP G +PI Y VE P +KW ++ R D V +G+
Sbjct: 7987 HVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMC-PVGTEKWMRVNSRPIKDLKFKVEEGV 8045
Query: 207 DPDTNYQFAVRAMNSHGPSPRSWPSDI 233
PD Y VRA+N+ G S PS+I
Sbjct: 8046 VPDKEYVLRVRAVNAIGVSE---PSEI 8069
Score = 70.5 bits (171), Expect = 8e-12
Identities = 67/239 (28%), Positives = 106/239 (44%), Gaps = 18/239 (7%)
Query: 26 RAAIRKPGKV-GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQE 83
+ I+ P ++ GPP K+ A + + W P + GSPI GY + E G+
Sbjct: 9284 KVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSP--YWS 9341
Query: 84 QLHSVPLSR-DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
++ P+++ + E + L G +Y+ A + AG G S P ++ D PP
Sbjct: 9342 RVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSD-PEVAGDPIFPP 9400
Query: 143 AAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHE---RIQMD 199
P P V + S ++L WKP A +G +PI+ Y VE ++ + W ++E I
Sbjct: 9401 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVE-MQEEGTTDWKRVNEPDKLITTC 9459
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ L Y+F V+A+N G S P +I T EE P D+GA
Sbjct: 9460 ECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEE-------PEVFIDIGA 9511
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/226 (26%), Positives = 100/226 (44%), Gaps = 23/226 (10%)
Query: 10 RLLLLASSL-GPGAVS-------LRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP 61
R +LA +L GPG S ++ I P G P +G T+ + W P H
Sbjct: 7649 RFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK---TSVRLNWTKPEHD 7705
Query: 62 G-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + I Y + + G D+ ++ ++ +PTT+ ++ L G EY + A ++A
Sbjct: 7706 GGAKIESYVIEMLKTGTDEWVR-------VAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7758
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G+ S P L ++ PP+ P+ VI ++ + L W +G +PI Y VE
Sbjct: 7759 GESEPSEPSD-PVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE- 7816
Query: 181 IRPDFDKK-WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ D +K W ++ ++ + L + Y F V A N+ G S
Sbjct: 7817 -KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS 7861
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/233 (25%), Positives = 102/233 (43%), Gaps = 13/233 (5%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
+ L + LG S+ ++ G GP DIK + ++ + W+ P G +PIL Y +
Sbjct: 8154 ITLENKLGSATASIN--VKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVL 8211
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
E G + +P+ + DL P EY + A ++ G G ++
Sbjct: 8212 ERREAG-------RRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8264
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
++QD PP P V + + ++WKP +G + I Y +E I +++W
Sbjct: 8265 -PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKG-EERWK 8322
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
+E + + + KGL+ YQF VRA N+ G S S + + + P +A
Sbjct: 8323 RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDA 8375
Score = 69.3 bits (168), Expect = 2e-11
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 19/216 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADK 79
G+ S ++ K GPP +K+ + + W+ P G S I Y V DK
Sbjct: 13070 GSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIV-------DK 13122
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQD 137
+ + +S +P T + L G EY+ I A ++ G G + P ++++
Sbjct: 13123 RETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP----AIAKN 13178
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
PP P + ++ + +SWKP A +G +PI Y +E R WT ++ + I
Sbjct: 13179 PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLE-KRETQAVNWTKVNRKPI 13237
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
++ GL T Y+F V A+N GP PSD
Sbjct: 13238 IERTLKATGLQEGTEYEFRVTAINKAGPGK---PSD 13270
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/213 (27%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP D+K+ + + + WKMP G I GY + +K + ++ D
Sbjct: 9608 GPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVI-------EKRTIDGKAWTKVNPDC 9660
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+T V+ DL +Y + A ++ G G TT ++D PP P + + +++
Sbjct: 9661 GSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT-ARDPIYPPDPPIKLKIGLIT 9719
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIR--PDFDKK--WTSIHER-IQMDSMVIKGLDPD 209
+ V LSWKP ++G +P+ +Y VE + P KK W ++R ++ ++ L
Sbjct: 9720 KNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEG 9779
Query: 210 TNYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V+A+N+ G PS P D R P
Sbjct: 9780 GEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMP 9812
Score = 67.8 bits (164), Expect = 5e-11
Identities = 55/212 (25%), Positives = 91/212 (42%), Gaps = 22/212 (10%)
Query: 38 PLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P ++K G + + + W+ P G SP+ GY V EV + L +P
Sbjct: 7186 PKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP- 7244
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGR---LSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
DL G EY + A ++ G G + P +++T P P P +
Sbjct: 7245 ------DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMST-------PATVPDPPENVKW 7291
Query: 154 SD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
D + + L+W P ++G + I+ Y VE P KW + E + M + GL+
Sbjct: 7292 RDRTANSIFLTWDPPKNDGGSRIKGYIVERC-PRGSDKWVACGEPVAETKMEVTGLEEGK 7350
Query: 211 NYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V+A+N G S S P++ I+ + +EA
Sbjct: 7351 WYAYRVKALNRQGASKPSRPTEEIQAVDTQEA 7382
Score = 67.8 bits (164), Expect = 5e-11
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 15/214 (7%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
L + + G VS++ + K GPP D+++ + + + WK P G S I Y V
Sbjct: 10984 LTVENPAGSKTVSVKVLVLD--KPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVV 11041
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPR 129
+V + + PLS L G +Y +AA +Q G+G + +P+
Sbjct: 11042 ERRDVASAQWS-------PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPK 11094
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D PP P+ H + V +EV+L W +G +PI Y VE+ + + + W
Sbjct: 11095 PIKAL--DPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEY-QEEGTQDW 11151
Query: 190 TSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
++ V+ GL Y+F V+A N G
Sbjct: 11152 IKFKTVTNLE-CVVTGLQQGKTYRFRVKAENIVG 11184
Score = 66.6 bits (161), Expect = 1e-10
Identities = 58/197 (29%), Positives = 82/197 (41%), Gaps = 11/197 (5%)
Query: 49 TAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPG 107
++ S+ W P+ G S + GY + E DK ++ I TT + L P
Sbjct: 24039 SSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHN------KTQITTTMYTVTGLVPD 24092
Query: 108 TEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGAS 167
EY+ I A + G +SP + +D P+ P + ++ +S V L W+
Sbjct: 24093 AEYQFRIIAQNDVGLSE-TSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPEC 24151
Query: 168 EGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS- 225
+G I Y VE+ R D W S ERI+ I GL T Y+F V A N G S
Sbjct: 24152 DGGKEILGYWVEY-RQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSR 24210
Query: 226 PRSWPSDIIRTLCPEEA 242
PR I L EA
Sbjct: 24211 PRRTAMSIKTKLTSGEA 24227
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/201 (27%), Positives = 85/201 (42%), Gaps = 12/201 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP +++ ++ ++ W P G SPI Y + +K +L +S DI
Sbjct: 14169 GPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYIL-------EKRETSRLLWTVVSEDI 14221
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ V L G EY ++A + GKG V + D PP P++P V V+
Sbjct: 14222 QSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMV--DRFGPPGPPEKPEVSNVT 14279
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQ 213
+ +SWK +G + I Y VE R +W +I + + GL + Y+
Sbjct: 14280 KNTATVSWKRPVDDGGSEITGYHVE-RREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYE 14338
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F V A N G P S SD +
Sbjct: 14339 FRVSAENRAGIGPPSEASDSV 14359
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/199 (25%), Positives = 89/199 (44%), Gaps = 13/199 (6%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ ++ + ++ W P G S I GY + E + + ++ V R
Sbjct: 19680 PPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKS 19739
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL--SQDSCLPPAAPQQPHVIVV 153
T L+ G EY + A + AG LS P + L ++D P+ P +P ++
Sbjct: 19740 T------GLREGCEYEYRVYAENAAG---LSLPSETSPLIRAEDPVFLPSPPSKPKIVDS 19790
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
+ + ++W +G API Y+VE+ + D D W + + ++ I GL Y
Sbjct: 19791 GKTTITIAWVKPLFDGGAPITGYTVEYKKSD-DTDWKTSIQSLRGTEYTISGLTTGAEYV 19849
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V+++N G S S SD
Sbjct: 19850 FRVKSVNKVGASDPSDSSD 19868
Score = 63.9 bits (154), Expect = 7e-10
Identities = 55/205 (26%), Positives = 94/205 (45%), Gaps = 21/205 (10%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP LD+K N + W P G S I G+ + + ++H+ +
Sbjct: 8893 GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDA--------KMHTWRQPIET 8944
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV-TTLSQDSCLPPAAPQQPHVIVV 153
++ I L G EY+ + A ++ G G P + L+ D PP +P++
Sbjct: 8945 ERSKCDITGLLEGQEYKFRVIAKNKFGCG---PPVEIGPILAVDPLGPPTSPERLTYTER 9001
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIR---PDFDKKWTSIHERI-QMDSMVIKGLDPD 209
+ S + L WK S G +PIQ Y +E R PDF++ +++R+ S +++ LD
Sbjct: 9002 TKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFER----VNKRLCPTTSFLVENLDEH 9057
Query: 210 TNYQFAVRAMNSHGPSPRSWPSDII 234
Y+F V+A+N G S S P +++
Sbjct: 9058 QMYEFRVKAVNEIGESEPSLPLNVV 9082
Score = 63.5 bits (153), Expect = 9e-10
Identities = 54/204 (26%), Positives = 89/204 (43%), Gaps = 14/204 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ A+ + + W P G + I GY + +K +E + ++
Sbjct: 18598 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYIL-------EKRDKEGVRWTKCNKKT 18650
Query: 95 PTTEEV-IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
T + + L G Y +AA + AG G S P V + D+ PP P P V
Sbjct: 18651 LTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPS-VFYRACDALYPPGPPSNPKVTDT 18709
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMVIKGLDPDTN 211
S S V+L+W +G AP++ Y VE ++ +WT+ +Q + L +T
Sbjct: 18710 SRSSVSLAWSKPIYDGGAPVKGYVVE-VKEAAADEWTTCTPPTGLQGKQFTVTKLKENTE 18768
Query: 212 YQFAVRAMNSHG-PSPRSWPSDII 234
Y F + A+NS G P + P ++
Sbjct: 18769 YNFRICAINSEGVGEPATLPGSVV 18792
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/220 (25%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVP 89
KPG+ PP K+ T + W P + G I GY + +K + VP
Sbjct: 12090 KPGRPDPPEVTKVSKEEMT---VVWNPPEYDGGKSITGYFL-------EKKEKHSTRWVP 12139
Query: 90 LSRD-IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
+++ IP + +L P EY+ + A ++ G G S P +++D PP P
Sbjct: 12140 VNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSR-PVVAKDPIEPPGPPTNF 12198
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-----DKKWTSIHERIQM--DSM 201
V+ + + L W +G API Y VE +RP D+ W + Q+
Sbjct: 12199 RVVDTTKHSITLGWGKPVYDGGAPIIGYVVE-MRPKIADASPDEGWKRCNAAAQLVRKEF 12257
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
+ LD + Y+F V A N G P+++ + P+E
Sbjct: 12258 TVTSLDENQEYEFRVCAQNQVGIGR---PAELKEAIKPKE 12294
Score = 62.8 bits (151), Expect = 2e-09
Identities = 50/191 (26%), Positives = 83/191 (43%), Gaps = 11/191 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + + ++ W P GS I GY + E KSL L I
Sbjct: 20762 GPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY---FLEKRDKKSLG---WFKVLKETI 20815
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + + L ++Y+ + A + AG+G S P + D PP P + + +
Sbjct: 20816 RDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAA-DPIDPPGPPAKIRIADST 20874
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTNY 212
S + L W +G + + Y VE IR +++WT++ + ++ V+ L P NY
Sbjct: 20875 KSSITLGWSKPVYDGGSAVTGYVVE-IRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNY 20933
Query: 213 QFAVRAMNSHG 223
F V A+N G
Sbjct: 20934 YFRVSAVNCAG 20944
Score = 62.4 bits (150), Expect = 2e-09
Identities = 59/214 (27%), Positives = 86/214 (40%), Gaps = 25/214 (11%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSE------VGADKSLQEQL 85
G P + ++ +N + W P G SPI+GY + E V A+ +L
Sbjct: 12785 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL---- 12840
Query: 86 HSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAP 145
+ +TE L G EY I A ++AG S P T +P P
Sbjct: 12841 --------VRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTAR----MPVDPP 12888
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK--KWTSIHERIQMDSMVI 203
+P VI V+ S V+L W +G + I Y VE + DK + + +I +
Sbjct: 12889 GKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTA 12948
Query: 204 KGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTL 237
GL+ YQF A + SP S PSD + L
Sbjct: 12949 TGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12982
Score = 62.0 bits (149), Expect = 3e-09
Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 19/220 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G S + G+ GPP+ IK +++ ++ W P+ G S I Y + +
Sbjct: 9898 GTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI-------E 9950
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
K + V +S + I L G EY I A ++ G G T + S
Sbjct: 9951 KREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFS 10010
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
P AP +P V V+ + + ++W+ +G +P+ Y +E ++ K+W ++ R +
Sbjct: 10011 V--PGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLE-MKDTTSKRWKRVN-RDPI 10066
Query: 199 DSMV------IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+M + GL ++YQF V A+N+ G P S PSD
Sbjct: 10067 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD 10106
Score = 62.0 bits (149), Expect = 3e-09
Identities = 50/211 (23%), Positives = 96/211 (45%), Gaps = 10/211 (4%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYS 73
L S G++++ I + GPP I++ ++C + +I W P + G G +
Sbjct: 19162 LCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDG----GCQISNY 19217
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
V ++ H V S+ + T I L G+EY+ + A ++ GK S V
Sbjct: 19218 IVEKKETTSTTWHIV--SQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV-- 19273
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH 193
+++ PP P P V+ + S + ++W+ ++G + + Y +E+ + W+ +
Sbjct: 19274 VAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY-KERSSILWSKAN 19332
Query: 194 ERIQMDS-MVIKGLDPDTNYQFAVRAMNSHG 223
+ + D+ M + GLD Y++ V A N G
Sbjct: 19333 KILIADTQMKVSGLDEGLMYEYRVYAENIAG 19363
Score = 60.8 bits (146), Expect = 6e-09
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 20/221 (9%)
Query: 15 ASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYS 73
++ L AV ++ ++PG G P + +++ +QW P + G + I+GY +
Sbjct: 18183 SAPLDSKAVIVQYPFKEPGPPGTPF---VTSISKDQMLVQWHEPVNDGGTKIIGYHLEQK 18239
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
E + L +L+ P I T+ L G EY ++A + G G+ S
Sbjct: 18240 E--KNSILWVKLNKTP----IQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF- 18292
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-DKKW-TS 191
+++D C PP P+ IV++ + V L WK A +G + I Y VE + D D +W +
Sbjct: 18293 VARDPCDPPGRPE---AIVITRNNVTLKWKKPAYDGGSKITGYIVE--KKDLPDGRWMKA 18347
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + GL D Y+F V A N+ G S PSD
Sbjct: 18348 SFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNF--SEPSD 18386
Score = 60.8 bits (146), Expect = 6e-09
Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 19/233 (8%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L L +++G + ++R I KPG G P++ K + ++ W+ P G + T
Sbjct: 20640 LKLRNAMGSASATIRVQILDKPGPPGGPIEFK--TVTAEKITLLWRPPADDGGAKI--TH 20695
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
+ E + + S L I TT ++I G EY + A ++ G G
Sbjct: 20696 YIVEKRETSRVVWSMVSEHLEECIITTTKII----KGNEYIFRVRAVNKYGIGEPLESDS 20751
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-- 188
V +++++ + P P P V ++ + + + W ++G + I Y +E DKK
Sbjct: 20752 V--VAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLE----KRDKKSL 20805
Query: 189 -WTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
W + E I+ + GL +++YQ+ V A+N+ G P S PS+ + P
Sbjct: 20806 GWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADP 20858
Score = 60.8 bits (146), Expect = 6e-09
Identities = 63/227 (27%), Positives = 98/227 (43%), Gaps = 19/227 (8%)
Query: 12 LLLASSLGPGAVSLRA-AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYT 69
L+L + G AV ++ I P PL+ + + + W+ P G + ILGY
Sbjct: 23902 LVLENKCGKKAVYIKVRVIGSPNSPEGPLEYD--DIQVRSVRVSWRPPADDGGADILGYI 23959
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSP 128
+ EV + + + T V+ LK EY ++A +Q G + L S
Sbjct: 23960 LERREV-------PKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSE 24012
Query: 129 RHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
VT + + PP P P V+ V+ S V+LSW +G + + Y +E DK
Sbjct: 24013 EPVTPKTPLN--PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDK 24070
Query: 188 KWTSIHERIQMDSMV--IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
W H + Q+ + + + GL PD YQF + A N G S S S+
Sbjct: 24071 -WVR-HNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASE 24115
Score = 60.5 bits (145), Expect = 8e-09
Identities = 47/201 (23%), Positives = 92/201 (45%), Gaps = 7/201 (3%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
G P + ++ + ++ W+ P + G SP+ GY + + + + ++++ P+
Sbjct: 10013 GAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKR--WKRVNRDPIKAMT 10070
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ L G++Y+ + A + AG G S P T ++D PP P P V +
Sbjct: 10071 LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPAT-ARDPIAPPGPPF-PKVTDWT 10128
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTNYQ 213
S L W P +G + + Y VE+ + + ++W ++ ++ +V+ GL Y+
Sbjct: 10129 KSSADLEWSPPLKDGGSKVTGYIVEY-KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYK 10187
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F VRA+N G +D+I
Sbjct: 10188 FRVRAVNIAGIGEPGEVTDVI 10208
Score = 60.1 bits (144), Expect = 1e-08
Identities = 52/211 (24%), Positives = 92/211 (43%), Gaps = 17/211 (8%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
GPPL++ + +N S+ W+ P + G + T + E+ S++ + D+
Sbjct: 6887 GPPLNVTITDVNRFGVSLTWEPPEYDGGAEI--TNYVIELRDKTSIRWDTAMTVRAEDLS 6944
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + D+ G EY + A ++ G G+ S+ ++ P P P + SD
Sbjct: 6945 AT---VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD----PIERPSPPVNLTSSD 6997
Query: 156 ---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTN 211
S V L W+P +G +PI Y +E D W + ++ + + + GL+
Sbjct: 6998 QTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKD-NWIRCNMKLVPELTYKVTGLEKGNK 7056
Query: 212 YQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V A N G S PS+I+ L ++A
Sbjct: 7057 YLYRVSAENKAGVSD---PSEILGPLTADDA 7084
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/197 (27%), Positives = 78/197 (39%), Gaps = 12/197 (6%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP + + + + W PR G S I Y V D + +L S
Sbjct: 7478 KPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVV--ERRATDSEVWHKLSSTVKDT 7535
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T+ L P EY +AA + G G +T Q PP P +
Sbjct: 7536 NFKATK-----LIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFD--PPGPPTRLEPSD 7588
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKGLDPDTN 211
++ V L+W +G +PI Y VE + PD D KW ++ D+ +KGL
Sbjct: 7589 ITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD-KWVRCNKMPVKDTTYRVKGLTNKKK 7647
Query: 212 YQFAVRAMNSHGPSPRS 228
Y+F V A N GP S
Sbjct: 7648 YRFRVLAENLAGPGKPS 7664
Score = 59.3 bits (142), Expect = 2e-08
Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 18/226 (7%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLS 91
K GPP IK+ ++ T+ +I W+ P G+P+ GY V + L P+S
Sbjct: 23526 KPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWL-------PVS 23578
Query: 92 RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVI 151
+ + L G EY +AA ++ G G + S S P P+ +
Sbjct: 23579 ESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS--SIRIPGPPETLQIF 23636
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEF--IRPDFDKKWTSIHE-RIQMDSMVIKGLDP 208
VS + L+W P +G + + Y VE +R D +W +++ + M GL
Sbjct: 23637 DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRAD---RWVRVNKVPVTMTRYRSTGLTE 23693
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITD 254
Y+ V A+N+ G S PS I + P PR +TD
Sbjct: 23694 GLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPR-VTD 23738
Score = 59.3 bits (142), Expect = 2e-08
Identities = 67/216 (31%), Positives = 95/216 (43%), Gaps = 23/216 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEV--GADKSLQEQLHS 87
KP K P+ I+ AL + I WK P G S I Y V E GA+ L S
Sbjct: 24417 KPDKPTGPIVIE--ALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAIS 24474
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT--LSQDSCLPPAAP 145
V R + TE G +RVS A + G +S P V++ + + P AP
Sbjct: 24475 VTTCRIVNLTENA------GYYFRVS--AQNTFG---ISDPLEVSSVVIIKSPFEKPGAP 24523
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIK 204
+P + V+ ++WKP AS+G A I+ Y +E R KW S+ E I+ +K
Sbjct: 24524 GKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVK 24582
Query: 205 GLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPE 240
L Y+F V+ N G S W S+I + P+
Sbjct: 24583 NLIEGLEYEFRVKCENLGGES--EW-SEISEPITPK 24615
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/215 (25%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 19 GPGAVSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGA 77
GP VS + P G P + + + ++W P+ GSPILGY + EV +
Sbjct: 8581 GPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREVNS 8640
Query: 78 ------DKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+KSL L + + L G Y + A + AG G+ S P
Sbjct: 8641 THWSRVNKSLLNALKAN------------VDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8688
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
T + D PP P P V S + + L W+P A G I Y V+ ++
Sbjct: 8689 KT-AHDPISPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC 8746
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSP 226
+ I++ +K + +Y+ V A+N+ G P
Sbjct: 8747 TEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGP 8781
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/186 (25%), Positives = 80/186 (43%), Gaps = 11/186 (5%)
Query: 53 IQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRV 112
+ W P G PI Y + E ++ ++ V P T+ + DL G +Y
Sbjct: 10725 VTWNKPHDGGKPITNYILEKRE-----TMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 10779
Query: 113 SIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAP 172
++A ++ G G S P ++D P+ P P I + + V L+W+P +G +
Sbjct: 10780 RVSAENEIGIGDPSPPSK-PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSK 10838
Query: 173 IQYYSVEFIRPDFDKKWTSIH---ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRS 228
I Y VE+ + D++W + E + GL Y+F V A+N+ G S P
Sbjct: 10839 ILGYIVEYQKVG-DEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 10897
Query: 229 WPSDII 234
P ++
Sbjct: 10898 VPEPVL 10903
Score = 58.9 bits (141), Expect = 2e-08
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 15/217 (6%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTV 70
L L + G AV + +R GP D+K+ + T+ + W P + GS + Y V
Sbjct: 12373 LTLVNPAGEKAVFVN--VRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIV 12430
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG-RLSSPR 129
E AD+ ++ ++ T + +L PG EY + A ++ G G P+
Sbjct: 12431 EKRE--ADRKTWS-----TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPK 12483
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFD-KK 188
V L+ D P P++ V ++ + L+W P +G A I Y + + +
Sbjct: 12484 PV--LASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADR 12541
Query: 189 WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
WT + ++ S+V+ GL Y+F V A N+ G S
Sbjct: 12542 WTE-YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVS 12577
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/226 (26%), Positives = 95/226 (42%), Gaps = 20/226 (8%)
Query: 30 RKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSV 88
R PG G P+ + + S+ W P + G S + G+ V E + L +++++
Sbjct: 21450 RIPGPPGKPV---IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKE--RNSILWQKVNTS 21504
Query: 89 PLS-RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
P+S R+ T L G +Y+ + A + AG S P T + P P
Sbjct: 21505 PISGREYRAT-----GLVEGLDYQFRVYAENSAGLSSPSDPSKFTL----AVSPVDPPGT 21555
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH-ERIQMDSMVIKGL 206
P I V+ + L W P +G + I YS+E + +++W + + + GL
Sbjct: 21556 PDYIDVTRETITLKWNPPLRDGGSKIVGYSIE--KRQGNERWVRCNFTDVSECQYTVTGL 21613
Query: 207 DPDTNYQFAVRAMNSHGP-SPRSWPSDIIRTLCPEEAGSGRYGPRY 251
P Y+F + A N+ G SP S S II T +GP Y
Sbjct: 21614 SPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEY 21659
Score = 58.5 bits (140), Expect = 3e-08
Identities = 55/214 (25%), Positives = 96/214 (44%), Gaps = 13/214 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGAD 78
G S+ ++ + GPP + + + ++ WK P + GS I+ Y V E
Sbjct: 16318 GERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETS-- 16375
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
+L + ++ T + L G EY I A ++ G G V ++++
Sbjct: 16376 -----RLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPV--VAKNP 16428
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
+ P AP+ P V V+ + + W+ AS+G + I Y +E R +WT H+R+
Sbjct: 16429 FVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLE-KRDKEGIRWTRCHKRLIG 16487
Query: 199 D-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPS 231
+ + + GL + +Y+F V A N+ G S S PS
Sbjct: 16488 ELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPS 16521
Score = 58.5 bits (140), Expect = 3e-08
Identities = 54/236 (22%), Positives = 96/236 (40%), Gaps = 12/236 (5%)
Query: 2 DLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRH 60
D IR + +L S++G G S+ ++ + GPP +K+ + + W P
Sbjct: 18465 DCIRTDGGQYILKLSNVG-GTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQ 18523
Query: 61 PGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + + + +K +L +S ++ + L PG EY + A ++
Sbjct: 18524 DGGANISHYII------EKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 18577
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G G VT + PP P P V ++ + ++W +G I+ Y +E
Sbjct: 18578 GIGEPLESGPVTACNPYK--PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILE- 18634
Query: 181 IRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIR 235
R +WT +++ D + + GL +Y+F V A N+ G S PS R
Sbjct: 18635 KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 18690
Score = 58.2 bits (139), Expect = 4e-08
Identities = 59/212 (27%), Positives = 93/212 (43%), Gaps = 21/212 (9%)
Query: 36 GPPLDIKLGALNCTA--FSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
GPP + L+ T +I W+ P+ G SP++ Y V + D +S
Sbjct: 11300 GPPTG-PINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTW-------GVVSS 11351
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT-TLSQDSCLPPAAPQQPHVI 151
T+ I L+ G EY + A ++ G G P T T+++ PP+ P +P V
Sbjct: 11352 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVG---PPLDSTPTVAKHKFSPPSPPGKPVVT 11408
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDT 210
++++ +SW S+G +PI Y +E R + KW +++ D + GL
Sbjct: 11409 DITENAATVSWTLPKSDGGSPITGYYME--RREVTGKWVRVNKTPIADLKFRVTGLYEGN 11466
Query: 211 NYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V A N G PSP S P R + P
Sbjct: 11467 TYEFRVFAENLAGLSKPSPSSDPIKACRPIKP 11498
Score = 57.8 bits (138), Expect = 5e-08
Identities = 60/223 (26%), Positives = 94/223 (42%), Gaps = 19/223 (8%)
Query: 21 GAVSLRAAIRKPG-KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G +S++ + KPG GP IK + A +++W P+ G S I Y + +
Sbjct: 13761 GTISIKV-VGKPGIPTGP---IKFDEVTAEAMTLKWAPPKDDGGSEITNYIL-------E 13809
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQD 137
K V + + T + L G EY ++A ++ G G L S V D
Sbjct: 13810 KRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFD 13869
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
P AP P+++ V V+L+W G +PI Y +EF + W ++ I
Sbjct: 13870 V---PDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEF-KERNSLLWKRANKTPI 13925
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+M + GL Y+F V A+N G S PS+ + L P
Sbjct: 13926 RMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDP 13968
Score = 56.2 bits (134), Expect = 1e-07
Identities = 53/193 (27%), Positives = 85/193 (44%), Gaps = 14/193 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG G P+ + L + + + +QW P GS ++GY + E + L +L+ P
Sbjct: 16036 PGPPGTPV-VTLSSRD--SMEVQWNEPISDGGSRVIGYHLERKE--RNSILWVKLNKTP- 16089
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
IP T+ L+ G EY ++A + G G+ S +++D C PP P+
Sbjct: 16090 ---IPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECY-VARDPCDPPGRPE---A 16142
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
I+V+ + V L WK +G + I Y VE + + I + GL D
Sbjct: 16143 IIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDH 16202
Query: 211 NYQFAVRAMNSHG 223
Y+F V A N+ G
Sbjct: 16203 RYEFRVIARNAAG 16215
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/195 (26%), Positives = 84/195 (43%), Gaps = 13/195 (6%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQ-EQLHSVPL 90
G GPP ++ + ++ WK P G S I GY V E KSL+ + P+
Sbjct: 14265 GPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE---KKSLRWVRAIKTPV 14321
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
S D+ + L+ G+ Y ++A ++AG G S + L +D+ PP P PHV
Sbjct: 14322 S-DLRCK---VTGLQEGSTYEFRVSAENRAGIGPPSEASD-SVLMKDAAYPPGPPSNPHV 14376
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW--TSIHERIQMDSMVIKGLDP 208
+ +L+W +G I Y VE + D+ W + +++ V+ L
Sbjct: 14377 TDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVG-DEAWIKDTTGTALRITQFVVPDLQT 14435
Query: 209 DTNYQFAVRAMNSHG 223
Y F + A+N G
Sbjct: 14436 KEKYNFRISAINDAG 14450
Score = 55.5 bits (132), Expect = 3e-07
Identities = 55/211 (26%), Positives = 87/211 (41%), Gaps = 16/211 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG PP DI ++ A S+ W +P G S I Y V +V V
Sbjct: 12687 PGPPQPPFDIS--DIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDW-------VTA 12737
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQDSCLPPAAPQQPH 149
+ T +G L PG EY + A ++ G L+SP+ V +Q P+ P+
Sbjct: 12738 LASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMV---AQFPFGVPSEPKNAR 12794
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDP 208
V V+ + ++W S+G +PI Y +E + W ++ ++ GL
Sbjct: 12795 VTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN-SLLWVKANDTLVRSTEYPCAGLVE 12853
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
Y F + A+N G SP S P++ + P
Sbjct: 12854 GLEYSFRIYALNKAGSSPPSKPTEYVTARMP 12884
Score = 53.9 bits (128), Expect = 7e-07
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 15/201 (7%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLH 86
A+ G PP + ++ + + + W P G S I+ Y V + + ++
Sbjct: 15343 AVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCN-- 15400
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQ--DSCLPPAA 144
+ + + L G EY I A + AG +S+P + + D+ P
Sbjct: 15401 ----KKTLTDLRYKVSGLTEGHEYEFRIMAENAAG---ISAPSPTSPFYKACDTVFKPGP 15453
Query: 145 PQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMV 202
P P V+ S S ++++W +G + I Y VE P+ D +W + ++ S
Sbjct: 15454 PGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEED-EWQIVTPPAGLKATSYT 15512
Query: 203 IKGLDPDTNYQFAVRAMNSHG 223
I GL + Y+ + AMNS G
Sbjct: 15513 ITGLTENQEYKIRIYAMNSEG 15533
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/225 (25%), Positives = 96/225 (42%), Gaps = 17/225 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP L+++ + + ++ W +P GS I Y V E + +S ++
Sbjct: 14564 GPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREA------TRKSYSTATTKCH 14617
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T +V G L G EY + A ++ G G + S+ P+ P +++ ++
Sbjct: 14618 KCTYKVTG-LSEGCEYFFRVMAENEYGIGEPTETTEPVKASE----APSPPDSLNIMDIT 14672
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S V+L+W +G + I Y +E R D+ WT I ++ V++ L Y F
Sbjct: 14673 KSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQ-WTHI-TTVKGLECVVRNLTEGEEYTF 14730
Query: 215 AVRAMNSHGPS-PRSWPSDIIR--TLCPEEAGSGRYGPRYITDMG 256
V A+NS G S PR I++ T+ PE G Y I G
Sbjct: 14731 QVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 14775
Score = 52.8 bits (125), Expect = 2e-06
Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 11/200 (5%)
Query: 37 PPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ + ++W +P + GSPI Y V +V K Q + +
Sbjct: 7781 PPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRR-KGWQT------VDTTVK 7833
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T+ + L G+ Y +AA + G+ + + L++D+ P P V+ V+
Sbjct: 7834 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIED-SVLAKDTFTTPGPPYALAVVDVTK 7892
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQF 214
V L W+P ++G PIQ Y +E + +W + D + + + T QF
Sbjct: 7893 RHVDLKWEPPKNDGGRPIQRYVIE-KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQF 7951
Query: 215 AVRAMNSHGPSPRSWPSDII 234
VRA N G S P++I+
Sbjct: 7952 QVRAENEAGVGHPSEPTEIL 7971
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 18/194 (9%)
Query: 52 SIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RDIPTTEEVIGDLKPGTE 109
S+ W P+ G SPI GY + + E + L ++ + P+ RD T L G E
Sbjct: 13888 SLTWTDPKKTGGSPITGYHLEFKE--RNSLLWKRANKTPIRMRDFKVT-----GLTEGLE 13940
Query: 110 YRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEG 169
Y + A + AG G+ S P ++ D PP +P VI ++ + V L W +G
Sbjct: 13941 YEFRVMAINLAGVGKPSLPSE-PVVALDPIDPPG---KPEVINITRNSVTLIWTEPKYDG 13996
Query: 170 SAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+ Y VE R K W H + + + L Y+F +RA N+ G S
Sbjct: 13997 GHKLTGYIVE-KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAI--S 14053
Query: 229 WPSDIIRT-LCPEE 241
PS+ T +C +E
Sbjct: 14054 APSESTETIICKDE 14067
Score = 52.0 bits (123), Expect = 3e-06
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 14/182 (7%)
Query: 46 LNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDL 104
++ A SI+W+ P H G S I+GY V E ++E + VP + +V G L
Sbjct: 22547 VSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKE--NKVPC---LECNYKVTG-L 22600
Query: 105 KPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKP 164
G EY+ A + AG + S ++Q+ P AP +P V V+ S V+L W
Sbjct: 22601 VEGLEYQFRTYALNAAGVSKASEASR-PIMAQN---PVDAPGRPEVTDVTRSTVSLIWSA 22656
Query: 165 GASEGSAPIQYYSVEF--IRPDFDKKWTSIHERIQMDS-MVIKGLDPDTNYQFAVRAMNS 221
A +G + + Y +E + D +W + I D+ + L Y+F V A N+
Sbjct: 22657 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNA 22716
Query: 222 HG 223
G
Sbjct: 22717 AG 22718
Score = 52.0 bits (123), Expect = 3e-06
Identities = 53/221 (23%), Positives = 85/221 (38%), Gaps = 23/221 (10%)
Query: 19 GPGA------VSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
GPG + R + P G P ++ G + IQW P G + I Y V
Sbjct: 22916 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHII---IQWTKPESDGGNEISNYLV- 22971
Query: 72 YSEVGADKSLQEQLHSVPLSRD--IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
DK ++ L +++D + T + L G +Y+ + A + AG S
Sbjct: 22972 ------DKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEAS 23025
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ + + S P P P V+ + ++L+W +G I Y +E D D +W
Sbjct: 23026 NFISCREPS-YTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTD-QW 23083
Query: 190 TSIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+H I+ + L Y F V A+N G S S
Sbjct: 23084 YRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYS 23124
Score = 51.2 bits (121), Expect = 5e-06
Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 18/199 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+++ + ++ + + W+ P GSPI+ Y V K E+ ++ +
Sbjct: 13483 GPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV-------QKRDAERKSWSTVTTEC 13535
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + +L+ G Y + A ++ G G R SQ P V VS
Sbjct: 13536 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQT----PGPVVDLKVRSVS 13591
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S ++ WK S+G + I Y V+F+ + KW + + + + K L Y F
Sbjct: 13592 KSSCSIGWKKPHSDGGSRIIGYVVDFLTE--ENKWQRVMKSLSLQYSA-KDLTEGKEYTF 13648
Query: 215 AVRAMNSHGPSPRSWPSDI 233
V A N +G PS+I
Sbjct: 13649 RVSAENENG---EGTPSEI 13664
Score = 51.2 bits (121), Expect = 5e-06
Identities = 50/188 (26%), Positives = 80/188 (42%), Gaps = 13/188 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP K+ + + W++P + G S ++GY + Y E L + + + ++
Sbjct: 19283 GPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKE--RSSILWSKANKILIA--- 19337
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T+ + L G Y + A + AG G+ S ++D C PP QP V ++
Sbjct: 19338 -DTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDPPG---QPEVTNIT 19392
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQ 213
V+L W +G A I Y VE R D +W + IQ + L D Y+
Sbjct: 19393 RKSVSLKWSKPHYDGGAKITGYIVE-RRELPDGRWLKCNYTNIQETYFEVTELTEDQRYE 19451
Query: 214 FAVRAMNS 221
F V A N+
Sbjct: 19452 FRVFARNA 19459
Score = 51.2 bits (121), Expect = 5e-06
Identities = 74/330 (22%), Positives = 123/330 (37%), Gaps = 27/330 (8%)
Query: 11 LLLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYT 69
+L L + G +V++ + KPG PL+I L S+ W P+ G + Y
Sbjct: 19556 VLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN--GLTAEKCSLSWGRPQEDGGADIDYY 19613
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
+ +K L ++ T + L G EY + ++ G G
Sbjct: 19614 I------VEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESV 19667
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D P+ P + V+ + L W S+G + I Y +E R +W
Sbjct: 19668 AIKAL--DPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIE-RREKNSLRW 19724
Query: 190 TSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
++++ D V GL Y++ V A N+ G S S S +IR P S
Sbjct: 19725 VRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSK 19784
Query: 249 PRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
P+ + D I+ VKPL + VE KK ++ KT +
Sbjct: 19785 PKIV-------------DSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQS 19831
Query: 309 IPPTSASLP-VTTVAPQPIPIQRKGKNGVA 337
+ T ++ +TT A ++ K G +
Sbjct: 19832 LRGTEYTISGLTTGAEYVFRVKSVNKVGAS 19861
Score = 50.4 bits (119), Expect = 8e-06
Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 10/112 (8%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K PP++ + C + + W+ PRH GS ILGY V Y +VG D+ + H+
Sbjct: 10807 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVG-DEEWRRANHT---PE 10862
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV--TTLSQDSCLPP 142
P T+ + L+ G Y+ + A + AG+ S P HV L +D PP
Sbjct: 10863 SCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKDRLEPP 10911
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/207 (24%), Positives = 84/207 (40%), Gaps = 15/207 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PGKV P I+ + ++ W P + G +PI Y + +K +L +
Sbjct: 21747 PGKVVGP--IRFTNITGEKMTLWWDAPLNDGCAPITHYII-------EKRETSRLAWALI 21797
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
L G EY+ ++A ++ G GR V ++Q P AP P
Sbjct: 21798 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPV--VAQIQYTVPDAPGIPEP 21855
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDP 208
++ + + L+W S+G + IQ Y +E R +W + + I + GL
Sbjct: 21856 SNITGNSITLTWARPESDGGSEIQQYILE-RREKKSTRWVKVISKRPISETRFKVTGLTE 21914
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIR 235
Y+F V A N+ G P S S +I+
Sbjct: 21915 GNEYEFHVMAENAAGVGPASGISRLIK 21941
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/244 (21%), Positives = 98/244 (40%), Gaps = 15/244 (6%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L + ++ G AVS+ + PG G ++ CT + W +P+ G + + +
Sbjct: 22815 LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCT---LAWSLPQEDGGAEITHYI 22871
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
++ +L+ V + + PT V+ L EY + A ++ G G
Sbjct: 22872 ------VERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEP 22925
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
+ ++++S P+ P P + + + W S+G I Y V+ R +WT
Sbjct: 22926 I--VARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDK-REKKSLRWT 22982
Query: 191 SIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
+++ + + + L +YQF V A+N+ G S S S+ I P
Sbjct: 22983 RVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSA 23042
Query: 249 PRYI 252
PR +
Sbjct: 23043 PRVV 23046
Score = 49.3 bits (116), Expect = 2e-05
Identities = 56/219 (25%), Positives = 86/219 (39%), Gaps = 21/219 (9%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G S +R PP+++K+ + + SI W+ P GS I Y V +K
Sbjct: 16715 GTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIV-------EK 16767
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ + + I L+ G Y + A ++ G G + + D
Sbjct: 16768 REATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG-------LPAQTADPI 16820
Query: 140 LPPAAPQQPHVIVVSD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERI 196
PQ P I V D + V+LSW +G + I Y VE ++ +KW+ R+
Sbjct: 16821 KVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVE-MQAKHSEKWSEC-ARV 16878
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
+ VI L Y F V A+N G S PRS I+
Sbjct: 16879 KSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIV 16917
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/216 (25%), Positives = 88/216 (40%), Gaps = 15/216 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G+ S +R GPP D+K+ + T+ ++ W P GS I Y V +K
Sbjct: 15633 GSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIV-------EK 15685
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ ++ + T + L+ G Y + A ++ G G + T S +
Sbjct: 15686 RESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE----TAESVKAS 15741
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
P P + ++ V+ + V+LSW+ +G + I Y VE D KW + +++
Sbjct: 15742 ERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSD-KWATC-ATVKVT 15799
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
I GL Y F V A N G S PR +I
Sbjct: 15800 EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 15835
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/192 (22%), Positives = 81/192 (42%), Gaps = 13/192 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RD 93
GPP +++ + + ++ W P G S I+GY V +K + + + + R
Sbjct: 17515 GPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIV-------EKRDRSGIRWIKCNKRR 17567
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
I + L EY ++A + AG G SP V + D P P H++
Sbjct: 17568 ITDLRLRVTGLTEDHEYEFRVSAENAAGVGE-PSPATVYYKACDPVFKPGPPTNAHIVDT 17626
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTN 211
+ + + L+W +G + I Y VE + D +++W + + +++ I L
Sbjct: 17627 TKNSITLAWGKPIYDGGSEILGYVVEICKAD-EEEWQIVTPQTGLRVTRFEISKLTEHQE 17685
Query: 212 YQFAVRAMNSHG 223
Y+ V A+N G
Sbjct: 17686 YKIRVCALNKVG 17697
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/206 (22%), Positives = 87/206 (42%), Gaps = 14/206 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADK 79
G+ S ++ GPP ++ + + + + W+ P G+ + Y + DK
Sbjct: 17797 GSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVI-------DK 17849
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ +S T + +L G Y + A ++ G G T + +
Sbjct: 17850 RESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVE----TVDAVKAA 17905
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
PP+ P + + VS + +L W+ +G + + Y VE ++P +KW+ + E ++
Sbjct: 17906 EPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVE-MQPKGTEKWSIVAES-KVC 17963
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ V+ GL YQF V+A N G S
Sbjct: 17964 NAVVTGLSSGQEYQFRVKAYNEKGKS 17989
Score = 48.1 bits (113), Expect = 4e-05
Identities = 59/239 (24%), Positives = 93/239 (38%), Gaps = 28/239 (11%)
Query: 16 SSLGPGAVSLRAAIRKPGKV---------GPPLD-IKLGALNCTAFSIQWKMPRHPGS-P 64
S GP ++ R + + G V GPP IK ++ + W P + G P
Sbjct: 14826 SDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14885
Query: 65 ILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR 124
I Y V + + V L+ + T L G EY+ + A ++ G G
Sbjct: 14886 ISNYVVEMRQT-------DSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGP 14938
Query: 125 LSSPRHVTTLSQDSCLP---PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFI 181
+T+ + P P P P V V+ + +SW S+G +PI Y VE
Sbjct: 14939 -----GITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVE-R 14992
Query: 182 RPDFDKKWTSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ W ++ + + ++ GL Y+F V A N G S S PS+ + L P
Sbjct: 14993 KERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDP 15051
Score = 47.8 bits (112), Expect = 5e-05
Identities = 47/200 (23%), Positives = 77/200 (38%), Gaps = 13/200 (6%)
Query: 32 PGKVGPP-LDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVP 89
PG VG P L L +C + W P G SPI Y + +K ++ P
Sbjct: 10311 PGPVGTPFLAHNLTNESC---KLTWFSPEDDGGSPITNYVI-------EKRESDRRAWTP 10360
Query: 90 LSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPH 149
++ + + L G Y IAA + G G + + +P P+
Sbjct: 10361 VTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPER-PEDLE 10419
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPD 209
V V+ + V L+W P +G + I Y +E +K ++ + +KGL
Sbjct: 10420 VKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEG 10479
Query: 210 TNYQFAVRAMNSHGPSPRSW 229
Y++ V A+N G S+
Sbjct: 10480 DTYEYRVSAVNIVGQGKPSF 10499
Score = 47.4 bits (111), Expect = 7e-05
Identities = 52/207 (25%), Positives = 87/207 (42%), Gaps = 27/207 (13%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP++ + T+ +W+ P G S I+ YT L+++ + P S I
Sbjct: 8498 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYT-----------LEKKDKTKPDSEWI 8546
Query: 95 PTTEEV------IGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQDSCLPPAAPQ 146
T + + L G EY + A ++ G G +S P +++D PP AP
Sbjct: 8547 VVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP----LVAKDPFGPPDAPD 8602
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKG 205
+P V V+ + + + W GS + Y+ + R W+ +++ + + G
Sbjct: 8603 KPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEK--REVNSTHWSRVNKSLLNALKANVDG 8660
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSD 232
L Y F V A N+ GP S PSD
Sbjct: 8661 LLEGLTYVFRVCAENAAGPGKFSPPSD 8687
Score = 47.4 bits (111), Expect = 7e-05
Identities = 49/189 (25%), Positives = 78/189 (41%), Gaps = 13/189 (6%)
Query: 50 AFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGT 108
A ++ W +P+ G SPI GY + EV +++ P++ + + L G
Sbjct: 11414 AATVSWTLPKSDGGSPITGYYMERREVTGK---WVRVNKTPIA----DLKFRVTGLYEGN 11466
Query: 109 EYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASE 168
Y + A + AG + SP + PP P P + S L W S+
Sbjct: 11467 TYEFRVFAENLAGLSK-PSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSD 11525
Query: 169 GSAPIQYYSVEFIRPDFDKKWTSIH--ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGP-S 225
G +PI Y VE +P +W I+ E I+ + + GL Y+F ++A N G
Sbjct: 11526 GGSPILGYVVECQKPG-TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 11584
Query: 226 PRSWPSDII 234
PR +I
Sbjct: 11585 PRELAESVI 11593
Score = 47.4 bits (111), Expect = 7e-05
Identities = 51/219 (23%), Positives = 90/219 (41%), Gaps = 14/219 (6%)
Query: 13 LLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVF 71
+L +S G+ S ++ + GPP +++ + S+ W P G + + V
Sbjct: 17392 ILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYV- 17450
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+K +L ++ ++ T + L G EY I A ++ G G V
Sbjct: 17451 -----VEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPV 17505
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
L ++ + P P+ V ++ + + W S+G + I Y VE R +W
Sbjct: 17506 --LMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVE-KRDRSGIRWIK 17562
Query: 192 IHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHG---PSP 226
++R D + + GL D Y+F V A N+ G PSP
Sbjct: 17563 CNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSP 17601
Score = 47.0 bits (110), Expect = 9e-05
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 26/264 (9%)
Query: 22 AVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKS 80
A SL ++ GPP +I + + + + W +P + G+P+ Y + +K
Sbjct: 19960 AASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHI-------EKR 20012
Query: 81 LQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCL 140
+ V ++ + + +L+ G Y ++ ++ G G + + +++
Sbjct: 20013 EASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE---- 20068
Query: 141 PPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P+ P++ V +S V+L+W +G + I +Y VE + K W +
Sbjct: 20069 KPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKG-QKNWVKC-AVAKSTH 20126
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS-PRS--WPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ GL ++ Y F V A N G S PR P I L P E + P + + A
Sbjct: 20127 HVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNF-PSHTVYVRA 20185
Query: 258 GEDDEGFEDDLDLDISFEEVKPLP 281
G +L +DI KPLP
Sbjct: 20186 G-------SNLKVDIPISG-KPLP 20201
Score = 46.2 bits (108), Expect = 2e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 17/214 (7%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
L +S G +L + K GPP +K+ + + ++ W P++ G S I Y V
Sbjct: 15917 LTNSAGEAIETLNVIVLD--KPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIV- 15973
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
E + Q+ S ++R TT + LK G EY+ IAA ++ GK +
Sbjct: 15974 --EKRDTSTTTWQIVSATVAR---TTIKACR-LKTGCEYQFRIAAENRYGKSTYLNSE-- 16025
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWT 190
T++Q P P P V + S + + W S+G + + Y +E R + + W
Sbjct: 16026 PTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLE--RKERNSILWV 16083
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
+++ I GL+ Y+F V A N G
Sbjct: 16084 KLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVG 16117
Score = 46.2 bits (108), Expect = 2e-04
Identities = 49/192 (25%), Positives = 76/192 (39%), Gaps = 11/192 (5%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP+ ++ ++ I W+ P + G G + V + H V S
Sbjct: 18099 KPGPPVGPVRFDEVSADFVVISWEPPAYTG----GCQISNYIVEKRDTTTTTWHMV--SA 18152
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T I LK GTEY+ I A ++ GK + V + Q P P P V
Sbjct: 18153 TVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAV--IVQYPFKEPGPPGTPFVTS 18210
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTN 211
+S ++ + W ++G I Y +E + W +++ IQ GLD
Sbjct: 18211 ISKDQMLVQWHEPVNDGGTKIIGYHLE-QKEKNSILWVKLNKTPIQDTKFKTTGLDEGLE 18269
Query: 212 YQFAVRAMNSHG 223
Y+F V A N G
Sbjct: 18270 YEFKVSAENIVG 18281
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP I++ ++ ++ W P + G S + GY V + +E+ +V ++
Sbjct: 20863 GPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQ-----GEEEEWTTVSTKGEV 20917
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
TTE V+ +LKPG Y ++A + AG+G
Sbjct: 20918 RTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20946
Score = 45.8 bits (107), Expect = 2e-04
Identities = 32/118 (27%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 26 RAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQ 84
R A++ GP +D+K+ +++ ++ SI WK P GS I+GY V + + + Q
Sbjct: 13570 RDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDF--LTEENKWQRV 13627
Query: 85 LHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
+ S+ L DL G EY ++A ++ G+G +P +T +++D + P
Sbjct: 13628 MKSLSLQYSAK-------DLTEGKEYTFRVSAENENGEG---TPSEITVVARDDVVAP 13675
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + +SW P ++G + + +Y VE D K W+++ ++ S + L P Y
Sbjct: 12405 VTKTSCHVSWAPPENDGGSQVTHYIVEKREAD-RKTWSTVTPEVKKTSFHVTNLVPGNEY 12463
Query: 213 QFAVRAMNSHGPS-PRSWPSDII 234
F V A+N +GP P P ++
Sbjct: 12464 YFRVTAVNEYGPGVPTDVPKPVL 12486
Score = 43.9 bits (102), Expect = 8e-04
Identities = 60/208 (28%), Positives = 84/208 (40%), Gaps = 30/208 (14%)
Query: 36 GPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRD 93
GPP+ + + I WK P G S I Y + EVG D + P++
Sbjct: 10608 GPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWM-------PVTSA 10660
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL-SQDSCLPPAAPQQPHVIV 152
T + L G +Y I A + G +S P ++ ++D P AP QP V
Sbjct: 10661 SAKTTCKVSKLLEGKDYIFRIHAENLYG---ISDPLVSDSMKAKDRFRVPDAPDQPIVTE 10717
Query: 153 VSDSEVALSW-KPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM--VIKGLDPD 209
V+ ++W KP +G PI Y +E R K+W R+ D + K PD
Sbjct: 10718 VTKDSALVTWNKP--HDGGKPITNYILE-KRETMSKRWA----RVTKDPIHPYTKFRVPD 10770
Query: 210 ----TNYQFAVRAMNSHG---PSPRSWP 230
Y+F V A N G PSP S P
Sbjct: 10771 LLEGCQYEFRVSAENEIGIGDPSPPSKP 10798
Score = 43.9 bits (102), Expect = 8e-04
Identities = 56/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)
Query: 38 PLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P+++ + + + ++ W+ P G+ I Y V +K + ++ +
Sbjct: 18897 PVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIV-------EKRETTRKAYATITNNCTK 18949
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDS 156
T I +L+ G Y + A ++ G G + +S+ PP P + ++ V+ +
Sbjct: 18950 TTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE----PPLPPGRVTLVDVTRN 19005
Query: 157 EVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAV 216
+ W+ S+G + I Y VE ++ +KW++ +++ I GL Y F V
Sbjct: 19006 TATIKWEKPESDGGSKITGYVVE-MQTKGSEKWSTC-TQVKTLEATISGLTAGEEYVFRV 19063
Query: 217 RAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFE 275
A+N G S PR +I E P + ++ A E L +D+ F+
Sbjct: 19064 AAVNEKGRSDPRQLGVPVIAR--DIEIKPSVELPFHTFNVKARE-------QLKIDVPFK 19114
Query: 276 EVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
+ + L E+ ++++S+ KT++ L
Sbjct: 19115 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSL 19147
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 14/119 (11%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLH 86
A++ PP + L ++ T+ S+ W+ P H GS +LGY V G +K
Sbjct: 17901 AVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEK------- 17953
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR--HVTTLSQDSCLPPA 143
+ + V+ L G EY+ + AY++ GK S PR V +++D + P+
Sbjct: 17954 -WSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGK---SDPRVLGVPVIAKDLTIQPS 18008
Score = 43.5 bits (101), Expect = 0.001
Identities = 51/217 (23%), Positives = 97/217 (44%), Gaps = 16/217 (7%)
Query: 29 IRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHS 87
I +PG V P+++ +++ + + W P+ G + I Y V E G + QL
Sbjct: 22433 IGRPGPVTGPIEVS--SVSAESCVLSWGEPKDGGGTEITNYIVEKRESG---TTAWQL-- 22485
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQ 146
++ + T+ + L EY +++ ++ G +S P +++ +PP+AP
Sbjct: 22486 --VNSSVKRTQIKVTHLTKYMEYSFRVSSENRFG---VSKPLESAPIIAEHPFVPPSAPT 22540
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKG 205
+P V VS + +++ W+ +G + I Y VE + W ++ ++ + + G
Sbjct: 22541 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTG 22599
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
L YQF A+N+ G S S S I P +A
Sbjct: 22600 LVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDA 22636
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/103 (30%), Positives = 42/103 (40%), Gaps = 7/103 (6%)
Query: 124 RLSSPRHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIR 182
R++ P V TL PP+ P+ P + V LSW G I YS+E R
Sbjct: 21339 RIAVPITVITLG-----PPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEK-R 21392
Query: 183 PDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
W + + + + L D YQF VRA N +G S
Sbjct: 21393 ETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 21435
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/217 (24%), Positives = 81/217 (37%), Gaps = 28/217 (12%)
Query: 27 AAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP----ILG--YTVFYSEVGADKS 80
+A+ K G VG PLD + IQ+ +P PG P I G T+ ++ +D
Sbjct: 21822 SAVNKFG-VGRPLDS-----DPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGG 21875
Query: 81 LQEQLH-------------SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSS 127
+ Q + V R I T + L G EY + A + AG G S
Sbjct: 21876 SEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASG 21935
Query: 128 PRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
+ ++ PP P V S + V+L W +G I Y +E + D
Sbjct: 21936 ISRLIKC-REPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLG- 21993
Query: 188 KWTSIH-ERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
W ++ E + L Y+F V A+N G
Sbjct: 21994 DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 22030
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P+ P + V+ + LSW P +G A I +Y V+ R WT++ +Q+
Sbjct: 15250 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQK-RETSRLAWTNVASEVQVTK 15308
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ + L Y F V A+N +G
Sbjct: 15309 LKVTKLLKGNEYIFRVMAVNKYG 15331
Score = 42.0 bits (97), Expect = 0.003
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 14/199 (7%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
P +K ++ + ++ W P + G I Y V + + V +S +
Sbjct: 17021 PKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIV------QKRDTTTTVWDV-VSATVA 17073
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + LK GTEY+ I A ++ G+ + ++Q P P P +S
Sbjct: 17074 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI--VAQYPYKEPGPPGTPFATAISK 17131
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWTSIHERIQMDSMV-IKGLDPDTNYQ 213
+ + W + G +P+ Y +E R + + WT +++ I D+ + L+ Y+
Sbjct: 17132 DSMVIQWHEPVNNGGSPVIGYHLE--RKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYE 17189
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V A N G S S+
Sbjct: 17190 FRVYAENIVGVGKASKNSE 17208
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/101 (28%), Positives = 42/101 (41%), Gaps = 1/101 (0%)
Query: 142 PAAPQQPHVI-VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI + + +SWKP A +G + I Y VE +W + I + +
Sbjct: 24418 PDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTT 24477
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
I L + Y F V A N+ G S S ++ P E
Sbjct: 24478 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFE 24518
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 23/190 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+ ++ + T ++W+ P + G I+GY V VG ++ S + I
Sbjct: 8699 GPPIP-RVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNE------WSRCTEKMI 8751
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ + +++ G +Y++ ++A + AG+G + VT A PQ+P +
Sbjct: 8752 KVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV---------AEPQEPPAV--- 8799
Query: 155 DSEVALSWKPGAS-EGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
E+ +S K G ++ +V RP K WT + D +VI + +
Sbjct: 8800 --ELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELI 8857
Query: 214 FAVRAMNSHG 223
HG
Sbjct: 8858 IKDALRKDHG 8867
Score = 40.0 bits (92), Expect = 0.011
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 1/98 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP++ ++ V L+W+P +G +P+ Y VE R K WT + + +
Sbjct: 7183 PSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVE-KREVSRKTWTKVMDFVTDLEF 7241
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ L Y F V A N GP ++ + + P
Sbjct: 7242 TVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTP 7279
Score = 40.0 bits (92), Expect = 0.011
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P P + VS + L+W P +G +PI+ Y +E R WT + E IQ
Sbjct: 14168 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILE-KRETSRLLWTVVSEDIQSCRH 14226
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
V L Y F V A+N +G
Sbjct: 14227 VATKLIQGNEYIFRVSAVNHYG 14248
Score = 39.3 bits (90), Expect = 0.019
Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 8/140 (5%)
Query: 92 RDIPTTEEVIGDLKP-GTEYRVSIAAYSQAGKGRLS--SPRHVTTLSQDSCL--PPAAPQ 146
RD PT + D+ P G++ + AA+ G L+ +P T+S + P P+
Sbjct: 10952 RDAPTKARI--DVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPR 11009
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGL 206
V + L+WK +G + I Y VE R +W+ + + S K L
Sbjct: 11010 DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER-RDVASAQWSPLSATSKKKSHFAKHL 11068
Query: 207 DPDTNYQFAVRAMNSHGPSP 226
+ Y F V A N +G P
Sbjct: 11069 NEGNQYLFRVAAENQYGRGP 11088
Score = 39.3 bits (90), Expect = 0.019
Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 9/112 (8%)
Query: 15 ASSLGPGA-VSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVF 71
A+ +GP + +S R+P GPP +K+ + T S++W P G I+GY +
Sbjct: 21927 AAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIE 21986
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
+ H V + T V DL+ G EY+ ++A + AGKG
Sbjct: 21987 MCKADLG-----DWHKVNAEACVKTRYTVT-DLQAGEEYKFRVSAINGAGKG 22032
Score = 38.9 bits (89), Expect = 0.025
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP + V V LSW+P +G A I Y VE R K + +I +
Sbjct: 18894 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE-KRETTRKAYATITNNCTKTTF 18952
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
I+ L +Y F V A N +G
Sbjct: 18953 RIENLQEGCSYYFRVLASNEYG 18974
Score = 38.9 bits (89), Expect = 0.025
Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 14/158 (8%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + L+W +G A I +Y VE R W + S V+ L + Y
Sbjct: 22847 VTQEKCTLAWSLPQEDGGAEITHYIVER-RETSRLNWVIVEGECPTLSYVVTRLIKNNEY 22905
Query: 213 QFAVRAMNSHGPSPRSWPSDIIRTL---------CPEEAGSGRYGPRYITDMGAGEDDEG 263
F VRA+N +GP I+ PEE G+G+ +I + +G
Sbjct: 22906 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK---EHIIIQWTKPESDG 22962
Query: 264 FEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISN 301
+ + + E K L T+ NK ++V ++ +++
Sbjct: 22963 GNEISNYLVDKREKKSLRWTR-VNKDYVVYDTRLKVTS 22999
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/100 (33%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
T+ D P P+ V VS V L+W AS+G + I Y VE + +W +
Sbjct: 24808 TVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRV 24866
Query: 193 HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + VI L T+YQF V A N G S S PS+
Sbjct: 24867 GQARETRYTVI-NLFGKTSYQFRVIAENKFGLSKPSEPSE 24905
Score = 37.7 bits (86), Expect = 0.055
Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 2/85 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI +++ V L W+P +G + + Y + R WT + +
Sbjct: 20265 PGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY-ILLKRETSTAVWTEVSATVARTM 20323
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS 225
M + L YQF ++A N G S
Sbjct: 20324 MKVMKLTTGEEYQFRIKAENRFGIS 20348
Score = 37.0 bits (84), Expect = 0.094
Identities = 36/171 (21%), Positives = 69/171 (40%), Gaps = 17/171 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP + ++ + ++ W P + G +PI+GY V AD S E + +
Sbjct: 12193 GPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 12252
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
E + L EY + A +Q G GR + +++ P + P + + +
Sbjct: 12253 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAE-------LKEAIKPKEILEPPEIDLDA 12305
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKG 205
+ + G PI+ +++ RP W ++ +D++V KG
Sbjct: 12306 SMRKLVIVRAG-----CPIRLFAIVRGRPAPKVTW----RKVGIDNVVRKG 12347
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDS 200
P P V +S ++W+P +G +PI Y V+ + D ++K W+++ S
Sbjct: 13482 PGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ--KRDAERKSWSTVTTECSKTS 13539
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ L+ +Y F V A N +G
Sbjct: 13540 FRVANLEEGKSYFFRVFAENEYG 13562
Score = 36.6 bits (83), Expect = 0.12
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
PAA Q+ V VS V L W P +G +PI Y +E R + W+ + + S
Sbjct: 21061 PAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE-KRDATKRTWSVVSHKCSSTSF 21119
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
+ L T + F V A N G
Sbjct: 21120 KLIDLSEKTPFFFRVLAENEIG 21141
Score = 34.3 bits (77), Expect = 0.61
Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 2/88 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ L W +G A I +Y VE R + W I E+ + L Y
Sbjct: 22155 VTRGSATLMWDAPLLDGGARIHHYVVEK-REASRRSWQVISEKCTRQIFKVNDLAEGVPY 22213
Query: 213 QFAVRAMNSHG-PSPRSWPSDIIRTLCP 239
F V A+N +G P P I+ T P
Sbjct: 22214 YFRVSAVNEYGVGEPYEMPEPIVATEQP 22241
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/142 (28%), Positives = 57/142 (40%), Gaps = 16/142 (11%)
Query: 89 PLS-RDIPTTEEV----IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPA 143
PLS + I TT E I + K G + R I ++ GK V + P
Sbjct: 6734 PLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDV-------PG 6786
Query: 144 APQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDSMV 202
+ V D EV+L+W+ ++G + I Y VE R D +K W +R +
Sbjct: 6787 PVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVE--RRDIKRKTWVLATDRAESCEFT 6844
Query: 203 IKGLDP-DTNYQFAVRAMNSHG 223
+ GL Y F V A N G
Sbjct: 6845 VTGLQKGGVEYLFRVSARNRVG 6866
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 11/197 (5%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQ-LHSVPLSR 92
+V P + ++L T ++ P H + + G + E ++++ E+ ++ +++
Sbjct: 9087 EVPPTIKLRLSVRGDT-IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 9145
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQQPHVI 151
+ + E +L R Y+ RL S R+V D P+ P+ V
Sbjct: 9146 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDR---PSPPRNLAVT 9202
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK---WTSIHERIQMDSMVIKGLDP 208
+ L+W G + I +Y ++ + D +K W + I L P
Sbjct: 9203 DIKAESCYLTWDAPLDNGGSEITHYVID--KRDASRKKAEWEEVTNTAVEKRYGIWKLIP 9260
Query: 209 DTNYQFAVRAMNSHGPS 225
+ Y+F VRA+N +G S
Sbjct: 9261 NGQYEFRVRAVNKYGIS 9277
Score = 32.0 bits (71), Expect = 3.0
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
V L +D+P E I + + I+A + +G + S+ +V P Q
Sbjct: 11650 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR-------PGPCQN 11702
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLD 207
V V+ +SW+ G + I + VE+ +P+ K W+ + + ++ L
Sbjct: 11703 LKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPN-QKGWSIVASDV-TKRLIKANLL 11760
Query: 208 PDTNYQFAVRAMNSHGPSP 226
+ Y F V A N G P
Sbjct: 11761 ANNEYYFRVCAENKVGVGP 11779
Score = 31.2 bits (69), Expect = 5.1
Identities = 21/93 (22%), Positives = 33/93 (35%), Gaps = 1/93 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P + ++ VS + W P +G IQ Y +E W++ +
Sbjct: 11992 PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETK-RMVWSTYSATVLTPGT 12050
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDII 234
+ L Y F VRA N G P + +I
Sbjct: 12051 TVTRLIEGNEYIFRVRAENKIGTGPPTESKPVI 12083
Score = 30.4 bits (67), Expect = 8.8
Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 8/124 (6%)
Query: 111 RVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGS 170
+ +I A +Q+GK + T L + P P V VS V ++W+ +G
Sbjct: 23209 KYTIEAENQSGK------KSATVLVKVYDTPGPCPSVK-VKEVSRDSVTITWEIPTIDGG 23261
Query: 171 APIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWP 230
AP+ Y VE R + + ++ + I GL T Y F V N +G
Sbjct: 23262 APVNNYIVE-KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCET 23320
Query: 231 SDII 234
SD +
Sbjct: 23321 SDAV 23324
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 81.3 bits (199), Expect = 4e-15
Identities = 65/205 (31%), Positives = 94/205 (45%), Gaps = 17/205 (8%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG+ PP+ + + ++ WK P G SPI GY + E A + + +
Sbjct: 13116 PGRCDPPV---ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPI-I 13171
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
R + T L+ GTEY + A ++AG G+ S ++D PP P P V
Sbjct: 13172 ERTLKAT-----GLQEGTEYEFRVTAINKAGPGKPSDASKAA-YARDPQYPPGPPAFPKV 13225
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT--SIHERIQMDSMVIKGLDP 208
+ S V+LSW A +G +PI Y VE R D D W ++ + +Q + GL
Sbjct: 13226 YDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSD-NWVRCNLPQNLQKTRFEVTGLME 13284
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDI 233
DT YQF V A+N G S PSD+
Sbjct: 13285 DTQYQFRVYAVNKIGYSD---PSDV 13306
Score = 77.0 bits (188), Expect = 8e-14
Identities = 64/207 (30%), Positives = 96/207 (46%), Gaps = 11/207 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + A ++ W P G SPI GY V + DK ++ + +P+
Sbjct: 7512 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR--CNKMPVK--- 7566
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
TT V G L +YR + A + AG G+ S L +D PP P +P V V
Sbjct: 7567 DTTYRVKG-LTNKKKYRFRVLAENLAGPGKPSKSTE-PILIKDPIDPPWPPGKPTVKDVG 7624
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
+ V L+W +G A I+ Y +E ++ D +W + E + ++ GL Y F
Sbjct: 7625 KTSVRLNWTKPEHDGGAKIESYVIEMLKTGTD-EWVRVAEGVPTTQHLLPGLMEGQEYSF 7683
Query: 215 AVRAMNSHGPSPRSWPSDIIRTLCPEE 241
VRA+N G S S PSD + LC E+
Sbjct: 7684 RVRAVNKAGESEPSEPSDPV--LCREK 7708
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/213 (26%), Positives = 94/213 (44%), Gaps = 13/213 (6%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFY 72
+ S L + R++IR PG PP +++ ++ ++ W P G S + GY V
Sbjct: 23542 IGSYLQSEVIECRSSIRIPG---PPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVER 23598
Query: 73 SEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT 132
EV AD+ ++ V ++R T L G EY + A + G G+ S P
Sbjct: 23599 KEVRADRWVRVNKVPVTMTRYRST------GLTEGLEYEHRVTAINARGSGKPSRPSK-P 23651
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
++ D PP PQ P V + + V+L+W EG + + Y +E + D +WT
Sbjct: 23652 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVD-QHEWTKC 23710
Query: 193 HER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGP 224
+ ++ + L Y+F V A N+ GP
Sbjct: 23711 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGP 23743
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/207 (28%), Positives = 92/207 (44%), Gaps = 26/207 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSE------VGADKSLQEQLHSV 88
GPP + + + ++W+ P++ G PI Y + E V A K+
Sbjct: 7813 GPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAG------ 7866
Query: 89 PLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
P + D+ GTE + + A ++AG G S P + ++ +D PP+ P
Sbjct: 7867 ------PDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI-EDPTSPPSPPLDL 7919
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD--SMVIKGL 206
HV +A++WKP G +PI Y VE P +KW ++ R D V +G+
Sbjct: 7920 HVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMC-PVGTEKWMRVNSRPIKDLKFKVEEGV 7978
Query: 207 DPDTNYQFAVRAMNSHGPSPRSWPSDI 233
PD Y VRA+N+ G S PS+I
Sbjct: 7979 VPDKEYVLRVRAVNAIGVSE---PSEI 8002
Score = 70.5 bits (171), Expect = 8e-12
Identities = 67/239 (28%), Positives = 106/239 (44%), Gaps = 18/239 (7%)
Query: 26 RAAIRKPGKV-GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQE 83
+ I+ P ++ GPP K+ A + + W P + GSPI GY + E G+
Sbjct: 9217 KVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSP--YWS 9274
Query: 84 QLHSVPLSR-DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
++ P+++ + E + L G +Y+ A + AG G S P ++ D PP
Sbjct: 9275 RVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSD-PEVAGDPIFPP 9333
Query: 143 AAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHE---RIQMD 199
P P V + S ++L WKP A +G +PI+ Y VE ++ + W ++E I
Sbjct: 9334 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVE-MQEEGTTDWKRVNEPDKLITTC 9392
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ L Y+F V+A+N G S P +I T EE P D+GA
Sbjct: 9393 ECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEE-------PEVFIDIGA 9444
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/226 (26%), Positives = 100/226 (44%), Gaps = 23/226 (10%)
Query: 10 RLLLLASSL-GPGAVS-------LRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP 61
R +LA +L GPG S ++ I P G P +G T+ + W P H
Sbjct: 7582 RFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK---TSVRLNWTKPEHD 7638
Query: 62 G-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + I Y + + G D+ ++ ++ +PTT+ ++ L G EY + A ++A
Sbjct: 7639 GGAKIESYVIEMLKTGTDEWVR-------VAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7691
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G+ S P L ++ PP+ P+ VI ++ + L W +G +PI Y VE
Sbjct: 7692 GESEPSEPSD-PVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE- 7749
Query: 181 IRPDFDKK-WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ D +K W ++ ++ + L + Y F V A N+ G S
Sbjct: 7750 -KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS 7794
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/233 (25%), Positives = 102/233 (43%), Gaps = 13/233 (5%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
+ L + LG S+ ++ G GP DIK + ++ + W+ P G +PIL Y +
Sbjct: 8087 ITLENKLGSATASIN--VKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVL 8144
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
E G + +P+ + DL P EY + A ++ G G ++
Sbjct: 8145 ERREAG-------RRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8197
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
++QD PP P V + + ++WKP +G + I Y +E I +++W
Sbjct: 8198 -PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKG-EERWK 8255
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
+E + + + KGL+ YQF VRA N+ G S S + + + P +A
Sbjct: 8256 RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDA 8308
Score = 69.3 bits (168), Expect = 2e-11
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 19/216 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADK 79
G+ S ++ K GPP +K+ + + W+ P G S I Y V DK
Sbjct: 13003 GSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIV-------DK 13055
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQD 137
+ + +S +P T + L G EY+ I A ++ G G + P ++++
Sbjct: 13056 RETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP----AIAKN 13111
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
PP P + ++ + +SWKP A +G +PI Y +E R WT ++ + I
Sbjct: 13112 PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLE-KRETQAVNWTKVNRKPI 13170
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
++ GL T Y+F V A+N GP PSD
Sbjct: 13171 IERTLKATGLQEGTEYEFRVTAINKAGPGK---PSD 13203
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/213 (27%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP D+K+ + + + WKMP G I GY + +K + ++ D
Sbjct: 9541 GPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVI-------EKRTIDGKAWTKVNPDC 9593
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+T V+ DL +Y + A ++ G G TT ++D PP P + + +++
Sbjct: 9594 GSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT-ARDPIYPPDPPIKLKIGLIT 9652
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIR--PDFDKK--WTSIHER-IQMDSMVIKGLDPD 209
+ V LSWKP ++G +P+ +Y VE + P KK W ++R ++ ++ L
Sbjct: 9653 KNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEG 9712
Query: 210 TNYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V+A+N+ G PS P D R P
Sbjct: 9713 GEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMP 9745
Score = 67.8 bits (164), Expect = 5e-11
Identities = 55/212 (25%), Positives = 91/212 (42%), Gaps = 22/212 (10%)
Query: 38 PLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P ++K G + + + W+ P G SP+ GY V EV + L +P
Sbjct: 7119 PKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP- 7177
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGR---LSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
DL G EY + A ++ G G + P +++T P P P +
Sbjct: 7178 ------DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMST-------PATVPDPPENVKW 7224
Query: 154 SD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
D + + L+W P ++G + I+ Y VE P KW + E + M + GL+
Sbjct: 7225 RDRTANSIFLTWDPPKNDGGSRIKGYIVERC-PRGSDKWVACGEPVAETKMEVTGLEEGK 7283
Query: 211 NYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V+A+N G S S P++ I+ + +EA
Sbjct: 7284 WYAYRVKALNRQGASKPSRPTEEIQAVDTQEA 7315
Score = 67.8 bits (164), Expect = 5e-11
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 15/214 (7%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
L + + G VS++ + K GPP D+++ + + + WK P G S I Y V
Sbjct: 10917 LTVENPAGSKTVSVKVLVLD--KPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVV 10974
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPR 129
+V + + PLS L G +Y +AA +Q G+G + +P+
Sbjct: 10975 ERRDVASAQWS-------PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPK 11027
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D PP P+ H + V +EV+L W +G +PI Y VE+ + + + W
Sbjct: 11028 PIKAL--DPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEY-QEEGTQDW 11084
Query: 190 TSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
++ V+ GL Y+F V+A N G
Sbjct: 11085 IKFKTVTNLE-CVVTGLQQGKTYRFRVKAENIVG 11117
Score = 66.6 bits (161), Expect = 1e-10
Identities = 58/197 (29%), Positives = 82/197 (41%), Gaps = 11/197 (5%)
Query: 49 TAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPG 107
++ S+ W P+ G S + GY + E DK ++ I TT + L P
Sbjct: 23972 SSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHN------KTQITTTMYTVTGLVPD 24025
Query: 108 TEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGAS 167
EY+ I A + G +SP + +D P+ P + ++ +S V L W+
Sbjct: 24026 AEYQFRIIAQNDVGLSE-TSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPEC 24084
Query: 168 EGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS- 225
+G I Y VE+ R D W S ERI+ I GL T Y+F V A N G S
Sbjct: 24085 DGGKEILGYWVEY-RQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSR 24143
Query: 226 PRSWPSDIIRTLCPEEA 242
PR I L EA
Sbjct: 24144 PRRTAMSIKTKLTSGEA 24160
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/201 (27%), Positives = 85/201 (42%), Gaps = 12/201 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP +++ ++ ++ W P G SPI Y + +K +L +S DI
Sbjct: 14102 GPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYIL-------EKRETSRLLWTVVSEDI 14154
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ V L G EY ++A + GKG V + D PP P++P V V+
Sbjct: 14155 QSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMV--DRFGPPGPPEKPEVSNVT 14212
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQ 213
+ +SWK +G + I Y VE R +W +I + + GL + Y+
Sbjct: 14213 KNTATVSWKRPVDDGGSEITGYHVE-RREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYE 14271
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F V A N G P S SD +
Sbjct: 14272 FRVSAENRAGIGPPSEASDSV 14292
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/199 (25%), Positives = 89/199 (44%), Gaps = 13/199 (6%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ ++ + ++ W P G S I GY + E + + ++ V R
Sbjct: 19613 PPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKS 19672
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL--SQDSCLPPAAPQQPHVIVV 153
T L+ G EY + A + AG LS P + L ++D P+ P +P ++
Sbjct: 19673 T------GLREGCEYEYRVYAENAAG---LSLPSETSPLIRAEDPVFLPSPPSKPKIVDS 19723
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
+ + ++W +G API Y+VE+ + D D W + + ++ I GL Y
Sbjct: 19724 GKTTITIAWVKPLFDGGAPITGYTVEYKKSD-DTDWKTSIQSLRGTEYTISGLTTGAEYV 19782
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V+++N G S S SD
Sbjct: 19783 FRVKSVNKVGASDPSDSSD 19801
Score = 63.9 bits (154), Expect = 7e-10
Identities = 55/205 (26%), Positives = 94/205 (45%), Gaps = 21/205 (10%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP LD+K N + W P G S I G+ + + ++H+ +
Sbjct: 8826 GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDA--------KMHTWRQPIET 8877
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV-TTLSQDSCLPPAAPQQPHVIVV 153
++ I L G EY+ + A ++ G G P + L+ D PP +P++
Sbjct: 8878 ERSKCDITGLLEGQEYKFRVIAKNKFGCG---PPVEIGPILAVDPLGPPTSPERLTYTER 8934
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIR---PDFDKKWTSIHERI-QMDSMVIKGLDPD 209
+ S + L WK S G +PIQ Y +E R PDF++ +++R+ S +++ LD
Sbjct: 8935 TKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFER----VNKRLCPTTSFLVENLDEH 8990
Query: 210 TNYQFAVRAMNSHGPSPRSWPSDII 234
Y+F V+A+N G S S P +++
Sbjct: 8991 QMYEFRVKAVNEIGESEPSLPLNVV 9015
Score = 63.5 bits (153), Expect = 9e-10
Identities = 54/204 (26%), Positives = 89/204 (43%), Gaps = 14/204 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ A+ + + W P G + I GY + +K +E + ++
Sbjct: 18531 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYIL-------EKRDKEGVRWTKCNKKT 18583
Query: 95 PTTEEV-IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
T + + L G Y +AA + AG G S P V + D+ PP P P V
Sbjct: 18584 LTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPS-VFYRACDALYPPGPPSNPKVTDT 18642
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMVIKGLDPDTN 211
S S V+L+W +G AP++ Y VE ++ +WT+ +Q + L +T
Sbjct: 18643 SRSSVSLAWSKPIYDGGAPVKGYVVE-VKEAAADEWTTCTPPTGLQGKQFTVTKLKENTE 18701
Query: 212 YQFAVRAMNSHG-PSPRSWPSDII 234
Y F + A+NS G P + P ++
Sbjct: 18702 YNFRICAINSEGVGEPATLPGSVV 18725
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/220 (25%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVP 89
KPG+ PP K+ T + W P + G I GY + +K + VP
Sbjct: 12023 KPGRPDPPEVTKVSKEEMT---VVWNPPEYDGGKSITGYFL-------EKKEKHSTRWVP 12072
Query: 90 LSRD-IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
+++ IP + +L P EY+ + A ++ G G S P +++D PP P
Sbjct: 12073 VNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSR-PVVAKDPIEPPGPPTNF 12131
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-----DKKWTSIHERIQM--DSM 201
V+ + + L W +G API Y VE +RP D+ W + Q+
Sbjct: 12132 RVVDTTKHSITLGWGKPVYDGGAPIIGYVVE-MRPKIADASPDEGWKRCNAAAQLVRKEF 12190
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
+ LD + Y+F V A N G P+++ + P+E
Sbjct: 12191 TVTSLDENQEYEFRVCAQNQVGIGR---PAELKEAIKPKE 12227
Score = 62.8 bits (151), Expect = 2e-09
Identities = 50/191 (26%), Positives = 83/191 (43%), Gaps = 11/191 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + + ++ W P GS I GY + E KSL L I
Sbjct: 20695 GPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY---FLEKRDKKSLG---WFKVLKETI 20748
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + + L ++Y+ + A + AG+G S P + D PP P + + +
Sbjct: 20749 RDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAA-DPIDPPGPPAKIRIADST 20807
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTNY 212
S + L W +G + + Y VE IR +++WT++ + ++ V+ L P NY
Sbjct: 20808 KSSITLGWSKPVYDGGSAVTGYVVE-IRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNY 20866
Query: 213 QFAVRAMNSHG 223
F V A+N G
Sbjct: 20867 YFRVSAVNCAG 20877
Score = 62.4 bits (150), Expect = 2e-09
Identities = 59/214 (27%), Positives = 86/214 (40%), Gaps = 25/214 (11%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSE------VGADKSLQEQL 85
G P + ++ +N + W P G SPI+GY + E V A+ +L
Sbjct: 12718 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL---- 12773
Query: 86 HSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAP 145
+ +TE L G EY I A ++AG S P T +P P
Sbjct: 12774 --------VRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTAR----MPVDPP 12821
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK--KWTSIHERIQMDSMVI 203
+P VI V+ S V+L W +G + I Y VE + DK + + +I +
Sbjct: 12822 GKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTA 12881
Query: 204 KGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTL 237
GL+ YQF A + SP S PSD + L
Sbjct: 12882 TGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12915
Score = 62.0 bits (149), Expect = 3e-09
Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 19/220 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G S + G+ GPP+ IK +++ ++ W P+ G S I Y + +
Sbjct: 9831 GTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI-------E 9883
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
K + V +S + I L G EY I A ++ G G T + S
Sbjct: 9884 KREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFS 9943
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
P AP +P V V+ + + ++W+ +G +P+ Y +E ++ K+W ++ R +
Sbjct: 9944 V--PGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLE-MKDTTSKRWKRVN-RDPI 9999
Query: 199 DSMV------IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+M + GL ++YQF V A+N+ G P S PSD
Sbjct: 10000 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD 10039
Score = 62.0 bits (149), Expect = 3e-09
Identities = 50/211 (23%), Positives = 96/211 (45%), Gaps = 10/211 (4%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYS 73
L S G++++ I + GPP I++ ++C + +I W P + G G +
Sbjct: 19095 LCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDG----GCQISNY 19150
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
V ++ H V S+ + T I L G+EY+ + A ++ GK S V
Sbjct: 19151 IVEKKETTSTTWHIV--SQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV-- 19206
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH 193
+++ PP P P V+ + S + ++W+ ++G + + Y +E+ + W+ +
Sbjct: 19207 VAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY-KERSSILWSKAN 19265
Query: 194 ERIQMDS-MVIKGLDPDTNYQFAVRAMNSHG 223
+ + D+ M + GLD Y++ V A N G
Sbjct: 19266 KILIADTQMKVSGLDEGLMYEYRVYAENIAG 19296
Score = 60.8 bits (146), Expect = 6e-09
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 20/221 (9%)
Query: 15 ASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYS 73
++ L AV ++ ++PG G P + +++ +QW P + G + I+GY +
Sbjct: 18116 SAPLDSKAVIVQYPFKEPGPPGTPF---VTSISKDQMLVQWHEPVNDGGTKIIGYHLEQK 18172
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
E + L +L+ P I T+ L G EY ++A + G G+ S
Sbjct: 18173 E--KNSILWVKLNKTP----IQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF- 18225
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-DKKW-TS 191
+++D C PP P+ IV++ + V L WK A +G + I Y VE + D D +W +
Sbjct: 18226 VARDPCDPPGRPE---AIVITRNNVTLKWKKPAYDGGSKITGYIVE--KKDLPDGRWMKA 18280
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + GL D Y+F V A N+ G S PSD
Sbjct: 18281 SFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNF--SEPSD 18319
Score = 60.8 bits (146), Expect = 6e-09
Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 19/233 (8%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L L +++G + ++R I KPG G P++ K + ++ W+ P G + T
Sbjct: 20573 LKLRNAMGSASATIRVQILDKPGPPGGPIEFK--TVTAEKITLLWRPPADDGGAKI--TH 20628
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
+ E + + S L I TT ++I G EY + A ++ G G
Sbjct: 20629 YIVEKRETSRVVWSMVSEHLEECIITTTKII----KGNEYIFRVRAVNKYGIGEPLESDS 20684
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-- 188
V +++++ + P P P V ++ + + + W ++G + I Y +E DKK
Sbjct: 20685 V--VAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLE----KRDKKSL 20738
Query: 189 -WTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
W + E I+ + GL +++YQ+ V A+N+ G P S PS+ + P
Sbjct: 20739 GWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADP 20791
Score = 60.8 bits (146), Expect = 6e-09
Identities = 63/227 (27%), Positives = 98/227 (43%), Gaps = 19/227 (8%)
Query: 12 LLLASSLGPGAVSLRA-AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYT 69
L+L + G AV ++ I P PL+ + + + W+ P G + ILGY
Sbjct: 23835 LVLENKCGKKAVYIKVRVIGSPNSPEGPLEYD--DIQVRSVRVSWRPPADDGGADILGYI 23892
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSP 128
+ EV + + + T V+ LK EY ++A +Q G + L S
Sbjct: 23893 LERREV-------PKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSE 23945
Query: 129 RHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
VT + + PP P P V+ V+ S V+LSW +G + + Y +E DK
Sbjct: 23946 EPVTPKTPLN--PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDK 24003
Query: 188 KWTSIHERIQMDSMV--IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
W H + Q+ + + + GL PD YQF + A N G S S S+
Sbjct: 24004 -WVR-HNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASE 24048
Score = 60.5 bits (145), Expect = 8e-09
Identities = 47/201 (23%), Positives = 92/201 (45%), Gaps = 7/201 (3%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
G P + ++ + ++ W+ P + G SP+ GY + + + + ++++ P+
Sbjct: 9946 GAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKR--WKRVNRDPIKAMT 10003
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ L G++Y+ + A + AG G S P T ++D PP P P V +
Sbjct: 10004 LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPAT-ARDPIAPPGPPF-PKVTDWT 10061
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTNYQ 213
S L W P +G + + Y VE+ + + ++W ++ ++ +V+ GL Y+
Sbjct: 10062 KSSADLEWSPPLKDGGSKVTGYIVEY-KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYK 10120
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F VRA+N G +D+I
Sbjct: 10121 FRVRAVNIAGIGEPGEVTDVI 10141
Score = 60.1 bits (144), Expect = 1e-08
Identities = 52/211 (24%), Positives = 92/211 (43%), Gaps = 17/211 (8%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
GPPL++ + +N S+ W+ P + G + T + E+ S++ + D+
Sbjct: 6820 GPPLNVTITDVNRFGVSLTWEPPEYDGGAEI--TNYVIELRDKTSIRWDTAMTVRAEDLS 6877
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + D+ G EY + A ++ G G+ S+ ++ P P P + SD
Sbjct: 6878 AT---VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD----PIERPSPPVNLTSSD 6930
Query: 156 ---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTN 211
S V L W+P +G +PI Y +E D W + ++ + + + GL+
Sbjct: 6931 QTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKD-NWIRCNMKLVPELTYKVTGLEKGNK 6989
Query: 212 YQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V A N G S PS+I+ L ++A
Sbjct: 6990 YLYRVSAENKAGVSD---PSEILGPLTADDA 7017
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/197 (27%), Positives = 78/197 (39%), Gaps = 12/197 (6%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP + + + + W PR G S I Y V D + +L S
Sbjct: 7411 KPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVV--ERRATDSEVWHKLSSTVKDT 7468
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T+ L P EY +AA + G G +T Q PP P +
Sbjct: 7469 NFKATK-----LIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFD--PPGPPTRLEPSD 7521
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKGLDPDTN 211
++ V L+W +G +PI Y VE + PD D KW ++ D+ +KGL
Sbjct: 7522 ITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD-KWVRCNKMPVKDTTYRVKGLTNKKK 7580
Query: 212 YQFAVRAMNSHGPSPRS 228
Y+F V A N GP S
Sbjct: 7581 YRFRVLAENLAGPGKPS 7597
Score = 59.3 bits (142), Expect = 2e-08
Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 18/226 (7%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLS 91
K GPP IK+ ++ T+ +I W+ P G+P+ GY V + L P+S
Sbjct: 23459 KPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWL-------PVS 23511
Query: 92 RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVI 151
+ + L G EY +AA ++ G G + S S P P+ +
Sbjct: 23512 ESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS--SIRIPGPPETLQIF 23569
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEF--IRPDFDKKWTSIHE-RIQMDSMVIKGLDP 208
VS + L+W P +G + + Y VE +R D +W +++ + M GL
Sbjct: 23570 DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRAD---RWVRVNKVPVTMTRYRSTGLTE 23626
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITD 254
Y+ V A+N+ G S PS I + P PR +TD
Sbjct: 23627 GLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPR-VTD 23671
Score = 59.3 bits (142), Expect = 2e-08
Identities = 67/216 (31%), Positives = 95/216 (43%), Gaps = 23/216 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEV--GADKSLQEQLHS 87
KP K P+ I+ AL + I WK P G S I Y V E GA+ L S
Sbjct: 24350 KPDKPTGPIVIE--ALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAIS 24407
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT--LSQDSCLPPAAP 145
V R + TE G +RVS A + G +S P V++ + + P AP
Sbjct: 24408 VTTCRIVNLTENA------GYYFRVS--AQNTFG---ISDPLEVSSVVIIKSPFEKPGAP 24456
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIK 204
+P + V+ ++WKP AS+G A I+ Y +E R KW S+ E I+ +K
Sbjct: 24457 GKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVK 24515
Query: 205 GLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPE 240
L Y+F V+ N G S W S+I + P+
Sbjct: 24516 NLIEGLEYEFRVKCENLGGES--EW-SEISEPITPK 24548
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/215 (25%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 19 GPGAVSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGA 77
GP VS + P G P + + + ++W P+ GSPILGY + EV +
Sbjct: 8514 GPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREVNS 8573
Query: 78 ------DKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+KSL L + + L G Y + A + AG G+ S P
Sbjct: 8574 THWSRVNKSLLNALKAN------------VDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8621
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
T + D PP P P V S + + L W+P A G I Y V+ ++
Sbjct: 8622 KT-AHDPISPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC 8679
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSP 226
+ I++ +K + +Y+ V A+N+ G P
Sbjct: 8680 TEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGP 8714
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/186 (25%), Positives = 80/186 (43%), Gaps = 11/186 (5%)
Query: 53 IQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRV 112
+ W P G PI Y + E ++ ++ V P T+ + DL G +Y
Sbjct: 10658 VTWNKPHDGGKPITNYILEKRE-----TMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 10712
Query: 113 SIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAP 172
++A ++ G G S P ++D P+ P P I + + V L+W+P +G +
Sbjct: 10713 RVSAENEIGIGDPSPPSK-PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSK 10771
Query: 173 IQYYSVEFIRPDFDKKWTSIH---ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRS 228
I Y VE+ + D++W + E + GL Y+F V A+N+ G S P
Sbjct: 10772 ILGYIVEYQKVG-DEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 10830
Query: 229 WPSDII 234
P ++
Sbjct: 10831 VPEPVL 10836
Score = 58.9 bits (141), Expect = 2e-08
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 15/217 (6%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTV 70
L L + G AV + +R GP D+K+ + T+ + W P + GS + Y V
Sbjct: 12306 LTLVNPAGEKAVFVN--VRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIV 12363
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG-RLSSPR 129
E AD+ ++ ++ T + +L PG EY + A ++ G G P+
Sbjct: 12364 EKRE--ADRKTWS-----TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPK 12416
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFD-KK 188
V L+ D P P++ V ++ + L+W P +G A I Y + + +
Sbjct: 12417 PV--LASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADR 12474
Query: 189 WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
WT + ++ S+V+ GL Y+F V A N+ G S
Sbjct: 12475 WTE-YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVS 12510
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/226 (26%), Positives = 95/226 (42%), Gaps = 20/226 (8%)
Query: 30 RKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSV 88
R PG G P+ + + S+ W P + G S + G+ V E + L +++++
Sbjct: 21383 RIPGPPGKPV---IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKE--RNSILWQKVNTS 21437
Query: 89 PLS-RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
P+S R+ T L G +Y+ + A + AG S P T + P P
Sbjct: 21438 PISGREYRAT-----GLVEGLDYQFRVYAENSAGLSSPSDPSKFTL----AVSPVDPPGT 21488
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH-ERIQMDSMVIKGL 206
P I V+ + L W P +G + I YS+E + +++W + + + GL
Sbjct: 21489 PDYIDVTRETITLKWNPPLRDGGSKIVGYSIE--KRQGNERWVRCNFTDVSECQYTVTGL 21546
Query: 207 DPDTNYQFAVRAMNSHGP-SPRSWPSDIIRTLCPEEAGSGRYGPRY 251
P Y+F + A N+ G SP S S II T +GP Y
Sbjct: 21547 SPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEY 21592
Score = 58.5 bits (140), Expect = 3e-08
Identities = 55/214 (25%), Positives = 96/214 (44%), Gaps = 13/214 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGAD 78
G S+ ++ + GPP + + + ++ WK P + GS I+ Y V E
Sbjct: 16251 GERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETS-- 16308
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
+L + ++ T + L G EY I A ++ G G V ++++
Sbjct: 16309 -----RLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPV--VAKNP 16361
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
+ P AP+ P V V+ + + W+ AS+G + I Y +E R +WT H+R+
Sbjct: 16362 FVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLE-KRDKEGIRWTRCHKRLIG 16420
Query: 199 D-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPS 231
+ + + GL + +Y+F V A N+ G S S PS
Sbjct: 16421 ELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPS 16454
Score = 58.5 bits (140), Expect = 3e-08
Identities = 54/236 (22%), Positives = 96/236 (40%), Gaps = 12/236 (5%)
Query: 2 DLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRH 60
D IR + +L S++G G S+ ++ + GPP +K+ + + W P
Sbjct: 18398 DCIRTDGGQYILKLSNVG-GTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQ 18456
Query: 61 PGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + + + +K +L +S ++ + L PG EY + A ++
Sbjct: 18457 DGGANISHYII------EKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 18510
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G G VT + PP P P V ++ + ++W +G I+ Y +E
Sbjct: 18511 GIGEPLESGPVTACNPYK--PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILE- 18567
Query: 181 IRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIR 235
R +WT +++ D + + GL +Y+F V A N+ G S PS R
Sbjct: 18568 KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 18623
Score = 58.2 bits (139), Expect = 4e-08
Identities = 59/212 (27%), Positives = 93/212 (43%), Gaps = 21/212 (9%)
Query: 36 GPPLDIKLGALNCTA--FSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
GPP + L+ T +I W+ P+ G SP++ Y V + D +S
Sbjct: 11233 GPPTG-PINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTW-------GVVSS 11284
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT-TLSQDSCLPPAAPQQPHVI 151
T+ I L+ G EY + A ++ G G P T T+++ PP+ P +P V
Sbjct: 11285 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVG---PPLDSTPTVAKHKFSPPSPPGKPVVT 11341
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDT 210
++++ +SW S+G +PI Y +E R + KW +++ D + GL
Sbjct: 11342 DITENAATVSWTLPKSDGGSPITGYYME--RREVTGKWVRVNKTPIADLKFRVTGLYEGN 11399
Query: 211 NYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V A N G PSP S P R + P
Sbjct: 11400 TYEFRVFAENLAGLSKPSPSSDPIKACRPIKP 11431
Score = 57.8 bits (138), Expect = 5e-08
Identities = 60/223 (26%), Positives = 94/223 (42%), Gaps = 19/223 (8%)
Query: 21 GAVSLRAAIRKPG-KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G +S++ + KPG GP IK + A +++W P+ G S I Y + +
Sbjct: 13694 GTISIKV-VGKPGIPTGP---IKFDEVTAEAMTLKWAPPKDDGGSEITNYIL-------E 13742
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQD 137
K V + + T + L G EY ++A ++ G G L S V D
Sbjct: 13743 KRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFD 13802
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
P AP P+++ V V+L+W G +PI Y +EF + W ++ I
Sbjct: 13803 V---PDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEF-KERNSLLWKRANKTPI 13858
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+M + GL Y+F V A+N G S PS+ + L P
Sbjct: 13859 RMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDP 13901
Score = 56.2 bits (134), Expect = 1e-07
Identities = 53/193 (27%), Positives = 85/193 (44%), Gaps = 14/193 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG G P+ + L + + + +QW P GS ++GY + E + L +L+ P
Sbjct: 15969 PGPPGTPV-VTLSSRD--SMEVQWNEPISDGGSRVIGYHLERKE--RNSILWVKLNKTP- 16022
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
IP T+ L+ G EY ++A + G G+ S +++D C PP P+
Sbjct: 16023 ---IPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECY-VARDPCDPPGRPE---A 16075
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
I+V+ + V L WK +G + I Y VE + + I + GL D
Sbjct: 16076 IIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDH 16135
Query: 211 NYQFAVRAMNSHG 223
Y+F V A N+ G
Sbjct: 16136 RYEFRVIARNAAG 16148
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/195 (26%), Positives = 84/195 (43%), Gaps = 13/195 (6%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQ-EQLHSVPL 90
G GPP ++ + ++ WK P G S I GY V E KSL+ + P+
Sbjct: 14198 GPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE---KKSLRWVRAIKTPV 14254
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
S D+ + L+ G+ Y ++A ++AG G S + L +D+ PP P PHV
Sbjct: 14255 S-DLRCK---VTGLQEGSTYEFRVSAENRAGIGPPSEASD-SVLMKDAAYPPGPPSNPHV 14309
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW--TSIHERIQMDSMVIKGLDP 208
+ +L+W +G I Y VE + D+ W + +++ V+ L
Sbjct: 14310 TDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVG-DEAWIKDTTGTALRITQFVVPDLQT 14368
Query: 209 DTNYQFAVRAMNSHG 223
Y F + A+N G
Sbjct: 14369 KEKYNFRISAINDAG 14383
Score = 55.5 bits (132), Expect = 3e-07
Identities = 55/211 (26%), Positives = 87/211 (41%), Gaps = 16/211 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG PP DI ++ A S+ W +P G S I Y V +V V
Sbjct: 12620 PGPPQPPFDIS--DIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDW-------VTA 12670
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQDSCLPPAAPQQPH 149
+ T +G L PG EY + A ++ G L+SP+ V +Q P+ P+
Sbjct: 12671 LASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMV---AQFPFGVPSEPKNAR 12727
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDP 208
V V+ + ++W S+G +PI Y +E + W ++ ++ GL
Sbjct: 12728 VTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN-SLLWVKANDTLVRSTEYPCAGLVE 12786
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
Y F + A+N G SP S P++ + P
Sbjct: 12787 GLEYSFRIYALNKAGSSPPSKPTEYVTARMP 12817
Score = 53.9 bits (128), Expect = 7e-07
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 15/201 (7%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLH 86
A+ G PP + ++ + + + W P G S I+ Y V + + ++
Sbjct: 15276 AVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCN-- 15333
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQ--DSCLPPAA 144
+ + + L G EY I A + AG +S+P + + D+ P
Sbjct: 15334 ----KKTLTDLRYKVSGLTEGHEYEFRIMAENAAG---ISAPSPTSPFYKACDTVFKPGP 15386
Query: 145 PQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMV 202
P P V+ S S ++++W +G + I Y VE P+ D +W + ++ S
Sbjct: 15387 PGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEED-EWQIVTPPAGLKATSYT 15445
Query: 203 IKGLDPDTNYQFAVRAMNSHG 223
I GL + Y+ + AMNS G
Sbjct: 15446 ITGLTENQEYKIRIYAMNSEG 15466
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/225 (25%), Positives = 96/225 (42%), Gaps = 17/225 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP L+++ + + ++ W +P GS I Y V E + +S ++
Sbjct: 14497 GPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREA------TRKSYSTATTKCH 14550
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T +V G L G EY + A ++ G G + S+ P+ P +++ ++
Sbjct: 14551 KCTYKVTG-LSEGCEYFFRVMAENEYGIGEPTETTEPVKASE----APSPPDSLNIMDIT 14605
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S V+L+W +G + I Y +E R D+ WT I ++ V++ L Y F
Sbjct: 14606 KSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQ-WTHI-TTVKGLECVVRNLTEGEEYTF 14663
Query: 215 AVRAMNSHGPS-PRSWPSDIIR--TLCPEEAGSGRYGPRYITDMG 256
V A+NS G S PR I++ T+ PE G Y I G
Sbjct: 14664 QVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 14708
Score = 52.8 bits (125), Expect = 2e-06
Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 11/200 (5%)
Query: 37 PPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ + ++W +P + GSPI Y V +V K Q + +
Sbjct: 7714 PPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRR-KGWQT------VDTTVK 7766
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T+ + L G+ Y +AA + G+ + + L++D+ P P V+ V+
Sbjct: 7767 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIED-SVLAKDTFTTPGPPYALAVVDVTK 7825
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQF 214
V L W+P ++G PIQ Y +E + +W + D + + + T QF
Sbjct: 7826 RHVDLKWEPPKNDGGRPIQRYVIE-KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQF 7884
Query: 215 AVRAMNSHGPSPRSWPSDII 234
VRA N G S P++I+
Sbjct: 7885 QVRAENEAGVGHPSEPTEIL 7904
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 18/194 (9%)
Query: 52 SIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RDIPTTEEVIGDLKPGTE 109
S+ W P+ G SPI GY + + E + L ++ + P+ RD T L G E
Sbjct: 13821 SLTWTDPKKTGGSPITGYHLEFKE--RNSLLWKRANKTPIRMRDFKVT-----GLTEGLE 13873
Query: 110 YRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEG 169
Y + A + AG G+ S P ++ D PP +P VI ++ + V L W +G
Sbjct: 13874 YEFRVMAINLAGVGKPSLPSE-PVVALDPIDPPG---KPEVINITRNSVTLIWTEPKYDG 13929
Query: 170 SAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+ Y VE R K W H + + + L Y+F +RA N+ G S
Sbjct: 13930 GHKLTGYIVE-KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAI--S 13986
Query: 229 WPSDIIRT-LCPEE 241
PS+ T +C +E
Sbjct: 13987 APSESTETIICKDE 14000
Score = 52.0 bits (123), Expect = 3e-06
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 14/182 (7%)
Query: 46 LNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDL 104
++ A SI+W+ P H G S I+GY V E ++E + VP + +V G L
Sbjct: 22480 VSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKE--NKVPC---LECNYKVTG-L 22533
Query: 105 KPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKP 164
G EY+ A + AG + S ++Q+ P AP +P V V+ S V+L W
Sbjct: 22534 VEGLEYQFRTYALNAAGVSKASEASR-PIMAQN---PVDAPGRPEVTDVTRSTVSLIWSA 22589
Query: 165 GASEGSAPIQYYSVEF--IRPDFDKKWTSIHERIQMDS-MVIKGLDPDTNYQFAVRAMNS 221
A +G + + Y +E + D +W + I D+ + L Y+F V A N+
Sbjct: 22590 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNA 22649
Query: 222 HG 223
G
Sbjct: 22650 AG 22651
Score = 52.0 bits (123), Expect = 3e-06
Identities = 53/221 (23%), Positives = 85/221 (38%), Gaps = 23/221 (10%)
Query: 19 GPGA------VSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
GPG + R + P G P ++ G + IQW P G + I Y V
Sbjct: 22849 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHII---IQWTKPESDGGNEISNYLV- 22904
Query: 72 YSEVGADKSLQEQLHSVPLSRD--IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
DK ++ L +++D + T + L G +Y+ + A + AG S
Sbjct: 22905 ------DKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEAS 22958
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ + + S P P P V+ + ++L+W +G I Y +E D D +W
Sbjct: 22959 NFISCREPS-YTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTD-QW 23016
Query: 190 TSIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+H I+ + L Y F V A+N G S S
Sbjct: 23017 YRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYS 23057
Score = 51.2 bits (121), Expect = 5e-06
Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 18/199 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+++ + ++ + + W+ P GSPI+ Y V K E+ ++ +
Sbjct: 13416 GPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV-------QKRDAERKSWSTVTTEC 13468
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + +L+ G Y + A ++ G G R SQ P V VS
Sbjct: 13469 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQT----PGPVVDLKVRSVS 13524
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S ++ WK S+G + I Y V+F+ + KW + + + + K L Y F
Sbjct: 13525 KSSCSIGWKKPHSDGGSRIIGYVVDFLTE--ENKWQRVMKSLSLQYSA-KDLTEGKEYTF 13581
Query: 215 AVRAMNSHGPSPRSWPSDI 233
V A N +G PS+I
Sbjct: 13582 RVSAENENG---EGTPSEI 13597
Score = 51.2 bits (121), Expect = 5e-06
Identities = 50/188 (26%), Positives = 80/188 (42%), Gaps = 13/188 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP K+ + + W++P + G S ++GY + Y E L + + + ++
Sbjct: 19216 GPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKE--RSSILWSKANKILIA--- 19270
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T+ + L G Y + A + AG G+ S ++D C PP QP V ++
Sbjct: 19271 -DTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDPPG---QPEVTNIT 19325
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQ 213
V+L W +G A I Y VE R D +W + IQ + L D Y+
Sbjct: 19326 RKSVSLKWSKPHYDGGAKITGYIVE-RRELPDGRWLKCNYTNIQETYFEVTELTEDQRYE 19384
Query: 214 FAVRAMNS 221
F V A N+
Sbjct: 19385 FRVFARNA 19392
Score = 51.2 bits (121), Expect = 5e-06
Identities = 74/330 (22%), Positives = 123/330 (37%), Gaps = 27/330 (8%)
Query: 11 LLLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYT 69
+L L + G +V++ + KPG PL+I L S+ W P+ G + Y
Sbjct: 19489 VLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN--GLTAEKCSLSWGRPQEDGGADIDYY 19546
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
+ +K L ++ T + L G EY + ++ G G
Sbjct: 19547 I------VEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESV 19600
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D P+ P + V+ + L W S+G + I Y +E R +W
Sbjct: 19601 AIKAL--DPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIE-RREKNSLRW 19657
Query: 190 TSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
++++ D V GL Y++ V A N+ G S S S +IR P S
Sbjct: 19658 VRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSK 19717
Query: 249 PRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
P+ + D I+ VKPL + VE KK ++ KT +
Sbjct: 19718 PKIV-------------DSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQS 19764
Query: 309 IPPTSASLP-VTTVAPQPIPIQRKGKNGVA 337
+ T ++ +TT A ++ K G +
Sbjct: 19765 LRGTEYTISGLTTGAEYVFRVKSVNKVGAS 19794
Score = 50.4 bits (119), Expect = 8e-06
Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 10/112 (8%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K PP++ + C + + W+ PRH GS ILGY V Y +VG D+ + H+
Sbjct: 10740 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVG-DEEWRRANHT---PE 10795
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV--TTLSQDSCLPP 142
P T+ + L+ G Y+ + A + AG+ S P HV L +D PP
Sbjct: 10796 SCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKDRLEPP 10844
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/207 (24%), Positives = 84/207 (40%), Gaps = 15/207 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PGKV P I+ + ++ W P + G +PI Y + +K +L +
Sbjct: 21680 PGKVVGP--IRFTNITGEKMTLWWDAPLNDGCAPITHYII-------EKRETSRLAWALI 21730
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
L G EY+ ++A ++ G GR V ++Q P AP P
Sbjct: 21731 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPV--VAQIQYTVPDAPGIPEP 21788
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDP 208
++ + + L+W S+G + IQ Y +E R +W + + I + GL
Sbjct: 21789 SNITGNSITLTWARPESDGGSEIQQYILE-RREKKSTRWVKVISKRPISETRFKVTGLTE 21847
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIR 235
Y+F V A N+ G P S S +I+
Sbjct: 21848 GNEYEFHVMAENAAGVGPASGISRLIK 21874
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/244 (21%), Positives = 98/244 (40%), Gaps = 15/244 (6%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L + ++ G AVS+ + PG G ++ CT + W +P+ G + + +
Sbjct: 22748 LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCT---LAWSLPQEDGGAEITHYI 22804
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
++ +L+ V + + PT V+ L EY + A ++ G G
Sbjct: 22805 ------VERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEP 22858
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
+ ++++S P+ P P + + + W S+G I Y V+ R +WT
Sbjct: 22859 I--VARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDK-REKKSLRWT 22915
Query: 191 SIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
+++ + + + L +YQF V A+N+ G S S S+ I P
Sbjct: 22916 RVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSA 22975
Query: 249 PRYI 252
PR +
Sbjct: 22976 PRVV 22979
Score = 49.3 bits (116), Expect = 2e-05
Identities = 56/219 (25%), Positives = 86/219 (39%), Gaps = 21/219 (9%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G S +R PP+++K+ + + SI W+ P GS I Y V +K
Sbjct: 16648 GTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIV-------EK 16700
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ + + I L+ G Y + A ++ G G + + D
Sbjct: 16701 REATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG-------LPAQTADPI 16753
Query: 140 LPPAAPQQPHVIVVSD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERI 196
PQ P I V D + V+LSW +G + I Y VE ++ +KW+ R+
Sbjct: 16754 KVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVE-MQAKHSEKWSEC-ARV 16811
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
+ VI L Y F V A+N G S PRS I+
Sbjct: 16812 KSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIV 16850
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/216 (25%), Positives = 88/216 (40%), Gaps = 15/216 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G+ S +R GPP D+K+ + T+ ++ W P GS I Y V +K
Sbjct: 15566 GSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIV-------EK 15618
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ ++ + T + L+ G Y + A ++ G G + T S +
Sbjct: 15619 RESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE----TAESVKAS 15674
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
P P + ++ V+ + V+LSW+ +G + I Y VE D KW + +++
Sbjct: 15675 ERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSD-KWATC-ATVKVT 15732
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
I GL Y F V A N G S PR +I
Sbjct: 15733 EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 15768
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/192 (22%), Positives = 81/192 (42%), Gaps = 13/192 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RD 93
GPP +++ + + ++ W P G S I+GY V +K + + + + R
Sbjct: 17448 GPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIV-------EKRDRSGIRWIKCNKRR 17500
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
I + L EY ++A + AG G SP V + D P P H++
Sbjct: 17501 ITDLRLRVTGLTEDHEYEFRVSAENAAGVGE-PSPATVYYKACDPVFKPGPPTNAHIVDT 17559
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTN 211
+ + + L+W +G + I Y VE + D +++W + + +++ I L
Sbjct: 17560 TKNSITLAWGKPIYDGGSEILGYVVEICKAD-EEEWQIVTPQTGLRVTRFEISKLTEHQE 17618
Query: 212 YQFAVRAMNSHG 223
Y+ V A+N G
Sbjct: 17619 YKIRVCALNKVG 17630
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/206 (22%), Positives = 87/206 (42%), Gaps = 14/206 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADK 79
G+ S ++ GPP ++ + + + + W+ P G+ + Y + DK
Sbjct: 17730 GSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVI-------DK 17782
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ +S T + +L G Y + A ++ G G T + +
Sbjct: 17783 RESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVE----TVDAVKAA 17838
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
PP+ P + + VS + +L W+ +G + + Y VE ++P +KW+ + E ++
Sbjct: 17839 EPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVE-MQPKGTEKWSIVAES-KVC 17896
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ V+ GL YQF V+A N G S
Sbjct: 17897 NAVVTGLSSGQEYQFRVKAYNEKGKS 17922
Score = 48.1 bits (113), Expect = 4e-05
Identities = 59/239 (24%), Positives = 93/239 (38%), Gaps = 28/239 (11%)
Query: 16 SSLGPGAVSLRAAIRKPGKV---------GPPLD-IKLGALNCTAFSIQWKMPRHPGS-P 64
S GP ++ R + + G V GPP IK ++ + W P + G P
Sbjct: 14759 SDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14818
Query: 65 ILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR 124
I Y V + + V L+ + T L G EY+ + A ++ G G
Sbjct: 14819 ISNYVVEMRQT-------DSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGP 14871
Query: 125 LSSPRHVTTLSQDSCLP---PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFI 181
+T+ + P P P P V V+ + +SW S+G +PI Y VE
Sbjct: 14872 -----GITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVE-R 14925
Query: 182 RPDFDKKWTSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ W ++ + + ++ GL Y+F V A N G S S PS+ + L P
Sbjct: 14926 KERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDP 14984
Score = 47.8 bits (112), Expect = 5e-05
Identities = 47/200 (23%), Positives = 77/200 (38%), Gaps = 13/200 (6%)
Query: 32 PGKVGPP-LDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVP 89
PG VG P L L +C + W P G SPI Y + +K ++ P
Sbjct: 10244 PGPVGTPFLAHNLTNESC---KLTWFSPEDDGGSPITNYVI-------EKRESDRRAWTP 10293
Query: 90 LSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPH 149
++ + + L G Y IAA + G G + + +P P+
Sbjct: 10294 VTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPER-PEDLE 10352
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPD 209
V V+ + V L+W P +G + I Y +E +K ++ + +KGL
Sbjct: 10353 VKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEG 10412
Query: 210 TNYQFAVRAMNSHGPSPRSW 229
Y++ V A+N G S+
Sbjct: 10413 DTYEYRVSAVNIVGQGKPSF 10432
Score = 47.4 bits (111), Expect = 7e-05
Identities = 52/207 (25%), Positives = 87/207 (42%), Gaps = 27/207 (13%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP++ + T+ +W+ P G S I+ YT L+++ + P S I
Sbjct: 8431 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYT-----------LEKKDKTKPDSEWI 8479
Query: 95 PTTEEV------IGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQDSCLPPAAPQ 146
T + + L G EY + A ++ G G +S P +++D PP AP
Sbjct: 8480 VVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP----LVAKDPFGPPDAPD 8535
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKG 205
+P V V+ + + + W GS + Y+ + R W+ +++ + + G
Sbjct: 8536 KPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEK--REVNSTHWSRVNKSLLNALKANVDG 8593
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSD 232
L Y F V A N+ GP S PSD
Sbjct: 8594 LLEGLTYVFRVCAENAAGPGKFSPPSD 8620
Score = 47.4 bits (111), Expect = 7e-05
Identities = 49/189 (25%), Positives = 78/189 (41%), Gaps = 13/189 (6%)
Query: 50 AFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGT 108
A ++ W +P+ G SPI GY + EV +++ P++ + + L G
Sbjct: 11347 AATVSWTLPKSDGGSPITGYYMERREVTGK---WVRVNKTPIA----DLKFRVTGLYEGN 11399
Query: 109 EYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASE 168
Y + A + AG + SP + PP P P + S L W S+
Sbjct: 11400 TYEFRVFAENLAGLSK-PSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSD 11458
Query: 169 GSAPIQYYSVEFIRPDFDKKWTSIH--ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGP-S 225
G +PI Y VE +P +W I+ E I+ + + GL Y+F ++A N G
Sbjct: 11459 GGSPILGYVVECQKPG-TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 11517
Query: 226 PRSWPSDII 234
PR +I
Sbjct: 11518 PRELAESVI 11526
Score = 47.4 bits (111), Expect = 7e-05
Identities = 51/219 (23%), Positives = 90/219 (41%), Gaps = 14/219 (6%)
Query: 13 LLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVF 71
+L +S G+ S ++ + GPP +++ + S+ W P G + + V
Sbjct: 17325 ILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYV- 17383
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+K +L ++ ++ T + L G EY I A ++ G G V
Sbjct: 17384 -----VEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPV 17438
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
L ++ + P P+ V ++ + + W S+G + I Y VE R +W
Sbjct: 17439 --LMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVE-KRDRSGIRWIK 17495
Query: 192 IHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHG---PSP 226
++R D + + GL D Y+F V A N+ G PSP
Sbjct: 17496 CNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSP 17534
Score = 47.0 bits (110), Expect = 9e-05
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 26/264 (9%)
Query: 22 AVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKS 80
A SL ++ GPP +I + + + + W +P + G+P+ Y + +K
Sbjct: 19893 AASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHI-------EKR 19945
Query: 81 LQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCL 140
+ V ++ + + +L+ G Y ++ ++ G G + + +++
Sbjct: 19946 EASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE---- 20001
Query: 141 PPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P+ P++ V +S V+L+W +G + I +Y VE + K W +
Sbjct: 20002 KPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKG-QKNWVKC-AVAKSTH 20059
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS-PRS--WPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ GL ++ Y F V A N G S PR P I L P E + P + + A
Sbjct: 20060 HVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNF-PSHTVYVRA 20118
Query: 258 GEDDEGFEDDLDLDISFEEVKPLP 281
G +L +DI KPLP
Sbjct: 20119 G-------SNLKVDIPISG-KPLP 20134
Score = 46.2 bits (108), Expect = 2e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 17/214 (7%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
L +S G +L + K GPP +K+ + + ++ W P++ G S I Y V
Sbjct: 15850 LTNSAGEAIETLNVIVLD--KPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIV- 15906
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
E + Q+ S ++R TT + LK G EY+ IAA ++ GK +
Sbjct: 15907 --EKRDTSTTTWQIVSATVAR---TTIKACR-LKTGCEYQFRIAAENRYGKSTYLNSE-- 15958
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWT 190
T++Q P P P V + S + + W S+G + + Y +E R + + W
Sbjct: 15959 PTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLE--RKERNSILWV 16016
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
+++ I GL+ Y+F V A N G
Sbjct: 16017 KLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVG 16050
Score = 46.2 bits (108), Expect = 2e-04
Identities = 49/192 (25%), Positives = 76/192 (39%), Gaps = 11/192 (5%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP+ ++ ++ I W+ P + G G + V + H V S
Sbjct: 18032 KPGPPVGPVRFDEVSADFVVISWEPPAYTG----GCQISNYIVEKRDTTTTTWHMV--SA 18085
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T I LK GTEY+ I A ++ GK + V + Q P P P V
Sbjct: 18086 TVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAV--IVQYPFKEPGPPGTPFVTS 18143
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTN 211
+S ++ + W ++G I Y +E + W +++ IQ GLD
Sbjct: 18144 ISKDQMLVQWHEPVNDGGTKIIGYHLE-QKEKNSILWVKLNKTPIQDTKFKTTGLDEGLE 18202
Query: 212 YQFAVRAMNSHG 223
Y+F V A N G
Sbjct: 18203 YEFKVSAENIVG 18214
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP I++ ++ ++ W P + G S + GY V + +E+ +V ++
Sbjct: 20796 GPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQ-----GEEEEWTTVSTKGEV 20850
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
TTE V+ +LKPG Y ++A + AG+G
Sbjct: 20851 RTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20879
Score = 45.8 bits (107), Expect = 2e-04
Identities = 32/118 (27%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 26 RAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQ 84
R A++ GP +D+K+ +++ ++ SI WK P GS I+GY V + + + Q
Sbjct: 13503 RDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDF--LTEENKWQRV 13560
Query: 85 LHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
+ S+ L DL G EY ++A ++ G+G +P +T +++D + P
Sbjct: 13561 MKSLSLQYSAK-------DLTEGKEYTFRVSAENENGEG---TPSEITVVARDDVVAP 13608
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + +SW P ++G + + +Y VE D K W+++ ++ S + L P Y
Sbjct: 12338 VTKTSCHVSWAPPENDGGSQVTHYIVEKREAD-RKTWSTVTPEVKKTSFHVTNLVPGNEY 12396
Query: 213 QFAVRAMNSHGPS-PRSWPSDII 234
F V A+N +GP P P ++
Sbjct: 12397 YFRVTAVNEYGPGVPTDVPKPVL 12419
Score = 43.9 bits (102), Expect = 8e-04
Identities = 60/208 (28%), Positives = 84/208 (40%), Gaps = 30/208 (14%)
Query: 36 GPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRD 93
GPP+ + + I WK P G S I Y + EVG D + P++
Sbjct: 10541 GPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWM-------PVTSA 10593
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL-SQDSCLPPAAPQQPHVIV 152
T + L G +Y I A + G +S P ++ ++D P AP QP V
Sbjct: 10594 SAKTTCKVSKLLEGKDYIFRIHAENLYG---ISDPLVSDSMKAKDRFRVPDAPDQPIVTE 10650
Query: 153 VSDSEVALSW-KPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM--VIKGLDPD 209
V+ ++W KP +G PI Y +E R K+W R+ D + K PD
Sbjct: 10651 VTKDSALVTWNKP--HDGGKPITNYILE-KRETMSKRWA----RVTKDPIHPYTKFRVPD 10703
Query: 210 ----TNYQFAVRAMNSHG---PSPRSWP 230
Y+F V A N G PSP S P
Sbjct: 10704 LLEGCQYEFRVSAENEIGIGDPSPPSKP 10731
Score = 43.9 bits (102), Expect = 8e-04
Identities = 56/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)
Query: 38 PLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P+++ + + + ++ W+ P G+ I Y V +K + ++ +
Sbjct: 18830 PVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIV-------EKRETTRKAYATITNNCTK 18882
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDS 156
T I +L+ G Y + A ++ G G + +S+ PP P + ++ V+ +
Sbjct: 18883 TTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE----PPLPPGRVTLVDVTRN 18938
Query: 157 EVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAV 216
+ W+ S+G + I Y VE ++ +KW++ +++ I GL Y F V
Sbjct: 18939 TATIKWEKPESDGGSKITGYVVE-MQTKGSEKWSTC-TQVKTLEATISGLTAGEEYVFRV 18996
Query: 217 RAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFE 275
A+N G S PR +I E P + ++ A E L +D+ F+
Sbjct: 18997 AAVNEKGRSDPRQLGVPVIAR--DIEIKPSVELPFHTFNVKARE-------QLKIDVPFK 19047
Query: 276 EVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
+ + L E+ ++++S+ KT++ L
Sbjct: 19048 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSL 19080
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 14/119 (11%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLH 86
A++ PP + L ++ T+ S+ W+ P H GS +LGY V G +K
Sbjct: 17834 AVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEK------- 17886
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR--HVTTLSQDSCLPPA 143
+ + V+ L G EY+ + AY++ GK S PR V +++D + P+
Sbjct: 17887 -WSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGK---SDPRVLGVPVIAKDLTIQPS 17941
Score = 43.5 bits (101), Expect = 0.001
Identities = 51/217 (23%), Positives = 97/217 (44%), Gaps = 16/217 (7%)
Query: 29 IRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHS 87
I +PG V P+++ +++ + + W P+ G + I Y V E G + QL
Sbjct: 22366 IGRPGPVTGPIEVS--SVSAESCVLSWGEPKDGGGTEITNYIVEKRESG---TTAWQL-- 22418
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQ 146
++ + T+ + L EY +++ ++ G +S P +++ +PP+AP
Sbjct: 22419 --VNSSVKRTQIKVTHLTKYMEYSFRVSSENRFG---VSKPLESAPIIAEHPFVPPSAPT 22473
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKG 205
+P V VS + +++ W+ +G + I Y VE + W ++ ++ + + G
Sbjct: 22474 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTG 22532
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
L YQF A+N+ G S S S I P +A
Sbjct: 22533 LVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDA 22569
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/103 (30%), Positives = 42/103 (40%), Gaps = 7/103 (6%)
Query: 124 RLSSPRHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIR 182
R++ P V TL PP+ P+ P + V LSW G I YS+E R
Sbjct: 21272 RIAVPITVITLG-----PPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEK-R 21325
Query: 183 PDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
W + + + + L D YQF VRA N +G S
Sbjct: 21326 ETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 21368
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/217 (24%), Positives = 81/217 (37%), Gaps = 28/217 (12%)
Query: 27 AAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP----ILG--YTVFYSEVGADKS 80
+A+ K G VG PLD + IQ+ +P PG P I G T+ ++ +D
Sbjct: 21755 SAVNKFG-VGRPLDS-----DPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGG 21808
Query: 81 LQEQLH-------------SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSS 127
+ Q + V R I T + L G EY + A + AG G S
Sbjct: 21809 SEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASG 21868
Query: 128 PRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
+ ++ PP P V S + V+L W +G I Y +E + D
Sbjct: 21869 ISRLIKC-REPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLG- 21926
Query: 188 KWTSIH-ERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
W ++ E + L Y+F V A+N G
Sbjct: 21927 DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21963
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P+ P + V+ + LSW P +G A I +Y V+ R WT++ +Q+
Sbjct: 15183 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQK-RETSRLAWTNVASEVQVTK 15241
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ + L Y F V A+N +G
Sbjct: 15242 LKVTKLLKGNEYIFRVMAVNKYG 15264
Score = 42.0 bits (97), Expect = 0.003
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 14/199 (7%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
P +K ++ + ++ W P + G I Y V + + V +S +
Sbjct: 16954 PKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIV------QKRDTTTTVWDV-VSATVA 17006
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + LK GTEY+ I A ++ G+ + ++Q P P P +S
Sbjct: 17007 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI--VAQYPYKEPGPPGTPFATAISK 17064
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWTSIHERIQMDSMV-IKGLDPDTNYQ 213
+ + W + G +P+ Y +E R + + WT +++ I D+ + L+ Y+
Sbjct: 17065 DSMVIQWHEPVNNGGSPVIGYHLE--RKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYE 17122
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V A N G S S+
Sbjct: 17123 FRVYAENIVGVGKASKNSE 17141
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/101 (28%), Positives = 42/101 (41%), Gaps = 1/101 (0%)
Query: 142 PAAPQQPHVI-VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI + + +SWKP A +G + I Y VE +W + I + +
Sbjct: 24351 PDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTT 24410
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
I L + Y F V A N+ G S S ++ P E
Sbjct: 24411 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFE 24451
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 23/190 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+ ++ + T ++W+ P + G I+GY V VG ++ S + I
Sbjct: 8632 GPPIP-RVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNE------WSRCTEKMI 8684
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ + +++ G +Y++ ++A + AG+G + VT A PQ+P +
Sbjct: 8685 KVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV---------AEPQEPPAV--- 8732
Query: 155 DSEVALSWKPGAS-EGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
E+ +S K G ++ +V RP K WT + D +VI + +
Sbjct: 8733 --ELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELI 8790
Query: 214 FAVRAMNSHG 223
HG
Sbjct: 8791 IKDALRKDHG 8800
Score = 40.0 bits (92), Expect = 0.011
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 1/98 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP++ ++ V L+W+P +G +P+ Y VE R K WT + + +
Sbjct: 7116 PSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVE-KREVSRKTWTKVMDFVTDLEF 7174
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ L Y F V A N GP ++ + + P
Sbjct: 7175 TVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTP 7212
Score = 40.0 bits (92), Expect = 0.011
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P P + VS + L+W P +G +PI+ Y +E R WT + E IQ
Sbjct: 14101 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILE-KRETSRLLWTVVSEDIQSCRH 14159
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
V L Y F V A+N +G
Sbjct: 14160 VATKLIQGNEYIFRVSAVNHYG 14181
Score = 39.3 bits (90), Expect = 0.019
Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 8/140 (5%)
Query: 92 RDIPTTEEVIGDLKP-GTEYRVSIAAYSQAGKGRLS--SPRHVTTLSQDSCL--PPAAPQ 146
RD PT + D+ P G++ + AA+ G L+ +P T+S + P P+
Sbjct: 10885 RDAPTKARI--DVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPR 10942
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGL 206
V + L+WK +G + I Y VE R +W+ + + S K L
Sbjct: 10943 DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER-RDVASAQWSPLSATSKKKSHFAKHL 11001
Query: 207 DPDTNYQFAVRAMNSHGPSP 226
+ Y F V A N +G P
Sbjct: 11002 NEGNQYLFRVAAENQYGRGP 11021
Score = 39.3 bits (90), Expect = 0.019
Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 9/112 (8%)
Query: 15 ASSLGPGA-VSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVF 71
A+ +GP + +S R+P GPP +K+ + T S++W P G I+GY +
Sbjct: 21860 AAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIE 21919
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
+ H V + T V DL+ G EY+ ++A + AGKG
Sbjct: 21920 MCKADLG-----DWHKVNAEACVKTRYTVT-DLQAGEEYKFRVSAINGAGKG 21965
Score = 38.9 bits (89), Expect = 0.025
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP + V V LSW+P +G A I Y VE R K + +I +
Sbjct: 18827 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE-KRETTRKAYATITNNCTKTTF 18885
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
I+ L +Y F V A N +G
Sbjct: 18886 RIENLQEGCSYYFRVLASNEYG 18907
Score = 38.9 bits (89), Expect = 0.025
Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 14/158 (8%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + L+W +G A I +Y VE R W + S V+ L + Y
Sbjct: 22780 VTQEKCTLAWSLPQEDGGAEITHYIVER-RETSRLNWVIVEGECPTLSYVVTRLIKNNEY 22838
Query: 213 QFAVRAMNSHGPSPRSWPSDIIRTL---------CPEEAGSGRYGPRYITDMGAGEDDEG 263
F VRA+N +GP I+ PEE G+G+ +I + +G
Sbjct: 22839 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK---EHIIIQWTKPESDG 22895
Query: 264 FEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISN 301
+ + + E K L T+ NK ++V ++ +++
Sbjct: 22896 GNEISNYLVDKREKKSLRWTR-VNKDYVVYDTRLKVTS 22932
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/100 (33%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
T+ D P P+ V VS V L+W AS+G + I Y VE + +W +
Sbjct: 24741 TVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRV 24799
Query: 193 HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + VI L T+YQF V A N G S S PS+
Sbjct: 24800 GQARETRYTVI-NLFGKTSYQFRVIAENKFGLSKPSEPSE 24838
Score = 37.7 bits (86), Expect = 0.055
Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 2/85 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI +++ V L W+P +G + + Y + R WT + +
Sbjct: 20198 PGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY-ILLKRETSTAVWTEVSATVARTM 20256
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS 225
M + L YQF ++A N G S
Sbjct: 20257 MKVMKLTTGEEYQFRIKAENRFGIS 20281
Score = 37.0 bits (84), Expect = 0.094
Identities = 36/171 (21%), Positives = 69/171 (40%), Gaps = 17/171 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP + ++ + ++ W P + G +PI+GY V AD S E + +
Sbjct: 12126 GPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 12185
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
E + L EY + A +Q G GR + +++ P + P + + +
Sbjct: 12186 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAE-------LKEAIKPKEILEPPEIDLDA 12238
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKG 205
+ + G PI+ +++ RP W ++ +D++V KG
Sbjct: 12239 SMRKLVIVRAG-----CPIRLFAIVRGRPAPKVTW----RKVGIDNVVRKG 12280
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDS 200
P P V +S ++W+P +G +PI Y V+ + D ++K W+++ S
Sbjct: 13415 PGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ--KRDAERKSWSTVTTECSKTS 13472
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ L+ +Y F V A N +G
Sbjct: 13473 FRVANLEEGKSYFFRVFAENEYG 13495
Score = 36.6 bits (83), Expect = 0.12
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
PAA Q+ V VS V L W P +G +PI Y +E R + W+ + + S
Sbjct: 20994 PAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE-KRDATKRTWSVVSHKCSSTSF 21052
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
+ L T + F V A N G
Sbjct: 21053 KLIDLSEKTPFFFRVLAENEIG 21074
Score = 34.3 bits (77), Expect = 0.61
Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 2/88 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ L W +G A I +Y VE R + W I E+ + L Y
Sbjct: 22088 VTRGSATLMWDAPLLDGGARIHHYVVEK-REASRRSWQVISEKCTRQIFKVNDLAEGVPY 22146
Query: 213 QFAVRAMNSHG-PSPRSWPSDIIRTLCP 239
F V A+N +G P P I+ T P
Sbjct: 22147 YFRVSAVNEYGVGEPYEMPEPIVATEQP 22174
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/142 (28%), Positives = 57/142 (40%), Gaps = 16/142 (11%)
Query: 89 PLS-RDIPTTEEV----IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPA 143
PLS + I TT E I + K G + R I ++ GK V + P
Sbjct: 6667 PLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDV-------PG 6719
Query: 144 APQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDSMV 202
+ V D EV+L+W+ ++G + I Y VE R D +K W +R +
Sbjct: 6720 PVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVE--RRDIKRKTWVLATDRAESCEFT 6777
Query: 203 IKGLDP-DTNYQFAVRAMNSHG 223
+ GL Y F V A N G
Sbjct: 6778 VTGLQKGGVEYLFRVSARNRVG 6799
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 11/197 (5%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQ-LHSVPLSR 92
+V P + ++L T ++ P H + + G + E ++++ E+ ++ +++
Sbjct: 9020 EVPPTIKLRLSVRGDT-IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 9078
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQQPHVI 151
+ + E +L R Y+ RL S R+V D P+ P+ V
Sbjct: 9079 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDR---PSPPRNLAVT 9135
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK---WTSIHERIQMDSMVIKGLDP 208
+ L+W G + I +Y ++ + D +K W + I L P
Sbjct: 9136 DIKAESCYLTWDAPLDNGGSEITHYVID--KRDASRKKAEWEEVTNTAVEKRYGIWKLIP 9193
Query: 209 DTNYQFAVRAMNSHGPS 225
+ Y+F VRA+N +G S
Sbjct: 9194 NGQYEFRVRAVNKYGIS 9210
Score = 32.0 bits (71), Expect = 3.0
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
V L +D+P E I + + I+A + +G + S+ +V P Q
Sbjct: 11583 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR-------PGPCQN 11635
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLD 207
V V+ +SW+ G + I + VE+ +P+ K W+ + + ++ L
Sbjct: 11636 LKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPN-QKGWSIVASDV-TKRLIKANLL 11693
Query: 208 PDTNYQFAVRAMNSHGPSP 226
+ Y F V A N G P
Sbjct: 11694 ANNEYYFRVCAENKVGVGP 11712
Score = 31.2 bits (69), Expect = 5.1
Identities = 21/93 (22%), Positives = 33/93 (35%), Gaps = 1/93 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P + ++ VS + W P +G IQ Y +E W++ +
Sbjct: 11925 PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETK-RMVWSTYSATVLTPGT 11983
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDII 234
+ L Y F VRA N G P + +I
Sbjct: 11984 TVTRLIEGNEYIFRVRAENKIGTGPPTESKPVI 12016
Score = 30.4 bits (67), Expect = 8.8
Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 8/124 (6%)
Query: 111 RVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGS 170
+ +I A +Q+GK + T L + P P V VS V ++W+ +G
Sbjct: 23142 KYTIEAENQSGK------KSATVLVKVYDTPGPCPSVK-VKEVSRDSVTITWEIPTIDGG 23194
Query: 171 APIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWP 230
AP+ Y VE R + + ++ + I GL T Y F V N +G
Sbjct: 23195 APVNNYIVE-KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCET 23253
Query: 231 SDII 234
SD +
Sbjct: 23254 SDAV 23257
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 81.3 bits (199), Expect = 4e-15
Identities = 65/205 (31%), Positives = 94/205 (45%), Gaps = 17/205 (8%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG+ PP+ + + ++ WK P G SPI GY + E A + + +
Sbjct: 12991 PGRCDPPV---ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPI-I 13046
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
R + T L+ GTEY + A ++AG G+ S ++D PP P P V
Sbjct: 13047 ERTLKAT-----GLQEGTEYEFRVTAINKAGPGKPSDASKAA-YARDPQYPPGPPAFPKV 13100
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT--SIHERIQMDSMVIKGLDP 208
+ S V+LSW A +G +PI Y VE R D D W ++ + +Q + GL
Sbjct: 13101 YDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSD-NWVRCNLPQNLQKTRFEVTGLME 13159
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDI 233
DT YQF V A+N G S PSD+
Sbjct: 13160 DTQYQFRVYAVNKIGYSD---PSDV 13181
Score = 77.0 bits (188), Expect = 8e-14
Identities = 64/207 (30%), Positives = 96/207 (46%), Gaps = 11/207 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + A ++ W P G SPI GY V + DK ++ + +P+
Sbjct: 7387 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR--CNKMPVK--- 7441
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
TT V G L +YR + A + AG G+ S L +D PP P +P V V
Sbjct: 7442 DTTYRVKG-LTNKKKYRFRVLAENLAGPGKPSKSTE-PILIKDPIDPPWPPGKPTVKDVG 7499
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
+ V L+W +G A I+ Y +E ++ D +W + E + ++ GL Y F
Sbjct: 7500 KTSVRLNWTKPEHDGGAKIESYVIEMLKTGTD-EWVRVAEGVPTTQHLLPGLMEGQEYSF 7558
Query: 215 AVRAMNSHGPSPRSWPSDIIRTLCPEE 241
VRA+N G S S PSD + LC E+
Sbjct: 7559 RVRAVNKAGESEPSEPSDPV--LCREK 7583
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/213 (26%), Positives = 94/213 (44%), Gaps = 13/213 (6%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFY 72
+ S L + R++IR PG PP +++ ++ ++ W P G S + GY V
Sbjct: 23417 IGSYLQSEVIECRSSIRIPG---PPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVER 23473
Query: 73 SEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT 132
EV AD+ ++ V ++R T L G EY + A + G G+ S P
Sbjct: 23474 KEVRADRWVRVNKVPVTMTRYRST------GLTEGLEYEHRVTAINARGSGKPSRPSK-P 23526
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
++ D PP PQ P V + + V+L+W EG + + Y +E + D +WT
Sbjct: 23527 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVD-QHEWTKC 23585
Query: 193 HER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGP 224
+ ++ + L Y+F V A N+ GP
Sbjct: 23586 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGP 23618
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/207 (28%), Positives = 92/207 (44%), Gaps = 26/207 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSE------VGADKSLQEQLHSV 88
GPP + + + ++W+ P++ G PI Y + E V A K+
Sbjct: 7688 GPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAG------ 7741
Query: 89 PLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
P + D+ GTE + + A ++AG G S P + ++ +D PP+ P
Sbjct: 7742 ------PDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI-EDPTSPPSPPLDL 7794
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD--SMVIKGL 206
HV +A++WKP G +PI Y VE P +KW ++ R D V +G+
Sbjct: 7795 HVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMC-PVGTEKWMRVNSRPIKDLKFKVEEGV 7853
Query: 207 DPDTNYQFAVRAMNSHGPSPRSWPSDI 233
PD Y VRA+N+ G S PS+I
Sbjct: 7854 VPDKEYVLRVRAVNAIGVSE---PSEI 7877
Score = 70.5 bits (171), Expect = 8e-12
Identities = 67/239 (28%), Positives = 106/239 (44%), Gaps = 18/239 (7%)
Query: 26 RAAIRKPGKV-GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQE 83
+ I+ P ++ GPP K+ A + + W P + GSPI GY + E G+
Sbjct: 9092 KVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSP--YWS 9149
Query: 84 QLHSVPLSR-DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
++ P+++ + E + L G +Y+ A + AG G S P ++ D PP
Sbjct: 9150 RVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSD-PEVAGDPIFPP 9208
Query: 143 AAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHE---RIQMD 199
P P V + S ++L WKP A +G +PI+ Y VE ++ + W ++E I
Sbjct: 9209 GPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVE-MQEEGTTDWKRVNEPDKLITTC 9267
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ L Y+F V+A+N G S P +I T EE P D+GA
Sbjct: 9268 ECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEE-------PEVFIDIGA 9319
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/226 (26%), Positives = 100/226 (44%), Gaps = 23/226 (10%)
Query: 10 RLLLLASSL-GPGAVS-------LRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP 61
R +LA +L GPG S ++ I P G P +G T+ + W P H
Sbjct: 7457 RFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK---TSVRLNWTKPEHD 7513
Query: 62 G-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + I Y + + G D+ ++ ++ +PTT+ ++ L G EY + A ++A
Sbjct: 7514 GGAKIESYVIEMLKTGTDEWVR-------VAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7566
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G+ S P L ++ PP+ P+ VI ++ + L W +G +PI Y VE
Sbjct: 7567 GESEPSEPSD-PVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE- 7624
Query: 181 IRPDFDKK-WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ D +K W ++ ++ + L + Y F V A N+ G S
Sbjct: 7625 -KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS 7669
Score = 69.7 bits (169), Expect = 1e-11
Identities = 59/233 (25%), Positives = 102/233 (43%), Gaps = 13/233 (5%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
+ L + LG S+ ++ G GP DIK + ++ + W+ P G +PIL Y +
Sbjct: 7962 ITLENKLGSATASIN--VKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVL 8019
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
E G + +P+ + DL P EY + A ++ G G ++
Sbjct: 8020 ERREAG-------RRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8072
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
++QD PP P V + + ++WKP +G + I Y +E I +++W
Sbjct: 8073 -PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKG-EERWK 8130
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
+E + + + KGL+ YQF VRA N+ G S S + + + P +A
Sbjct: 8131 RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDA 8183
Score = 69.3 bits (168), Expect = 2e-11
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 19/216 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADK 79
G+ S ++ K GPP +K+ + + W+ P G S I Y V DK
Sbjct: 12878 GSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIV-------DK 12930
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQD 137
+ + +S +P T + L G EY+ I A ++ G G + P ++++
Sbjct: 12931 RETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP----AIAKN 12986
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
PP P + ++ + +SWKP A +G +PI Y +E R WT ++ + I
Sbjct: 12987 PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLE-KRETQAVNWTKVNRKPI 13045
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
++ GL T Y+F V A+N GP PSD
Sbjct: 13046 IERTLKATGLQEGTEYEFRVTAINKAGPGK---PSD 13078
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/213 (27%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP D+K+ + + + WKMP G I GY + +K + ++ D
Sbjct: 9416 GPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVI-------EKRTIDGKAWTKVNPDC 9468
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+T V+ DL +Y + A ++ G G TT ++D PP P + + +++
Sbjct: 9469 GSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTT-ARDPIYPPDPPIKLKIGLIT 9527
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIR--PDFDKK--WTSIHER-IQMDSMVIKGLDPD 209
+ V LSWKP ++G +P+ +Y VE + P KK W ++R ++ ++ L
Sbjct: 9528 KNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEG 9587
Query: 210 TNYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V+A+N+ G PS P D R P
Sbjct: 9588 GEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMP 9620
Score = 67.8 bits (164), Expect = 5e-11
Identities = 55/212 (25%), Positives = 91/212 (42%), Gaps = 22/212 (10%)
Query: 38 PLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P ++K G + + + W+ P G SP+ GY V EV + L +P
Sbjct: 6994 PKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP- 7052
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGR---LSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
DL G EY + A ++ G G + P +++T P P P +
Sbjct: 7053 ------DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMST-------PATVPDPPENVKW 7099
Query: 154 SD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
D + + L+W P ++G + I+ Y VE P KW + E + M + GL+
Sbjct: 7100 RDRTANSIFLTWDPPKNDGGSRIKGYIVERC-PRGSDKWVACGEPVAETKMEVTGLEEGK 7158
Query: 211 NYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V+A+N G S S P++ I+ + +EA
Sbjct: 7159 WYAYRVKALNRQGASKPSRPTEEIQAVDTQEA 7190
Score = 67.8 bits (164), Expect = 5e-11
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 15/214 (7%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTV 70
L + + G VS++ + K GPP D+++ + + + WK P G S I Y V
Sbjct: 10792 LTVENPAGSKTVSVKVLVLD--KPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVV 10849
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPR 129
+V + + PLS L G +Y +AA +Q G+G + +P+
Sbjct: 10850 ERRDVASAQWS-------PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPK 10902
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D PP P+ H + V +EV+L W +G +PI Y VE+ + + + W
Sbjct: 10903 PIKAL--DPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEY-QEEGTQDW 10959
Query: 190 TSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
++ V+ GL Y+F V+A N G
Sbjct: 10960 IKFKTVTNLE-CVVTGLQQGKTYRFRVKAENIVG 10992
Score = 66.6 bits (161), Expect = 1e-10
Identities = 58/197 (29%), Positives = 82/197 (41%), Gaps = 11/197 (5%)
Query: 49 TAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPG 107
++ S+ W P+ G S + GY + E DK ++ I TT + L P
Sbjct: 23847 SSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHN------KTQITTTMYTVTGLVPD 23900
Query: 108 TEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGAS 167
EY+ I A + G +SP + +D P+ P + ++ +S V L W+
Sbjct: 23901 AEYQFRIIAQNDVGLSE-TSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPEC 23959
Query: 168 EGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS- 225
+G I Y VE+ R D W S ERI+ I GL T Y+F V A N G S
Sbjct: 23960 DGGKEILGYWVEY-RQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSR 24018
Query: 226 PRSWPSDIIRTLCPEEA 242
PR I L EA
Sbjct: 24019 PRRTAMSIKTKLTSGEA 24035
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/201 (27%), Positives = 85/201 (42%), Gaps = 12/201 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP +++ ++ ++ W P G SPI Y + +K +L +S DI
Sbjct: 13977 GPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYIL-------EKRETSRLLWTVVSEDI 14029
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ V L G EY ++A + GKG V + D PP P++P V V+
Sbjct: 14030 QSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMV--DRFGPPGPPEKPEVSNVT 14087
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT-SIHERIQMDSMVIKGLDPDTNYQ 213
+ +SWK +G + I Y VE R +W +I + + GL + Y+
Sbjct: 14088 KNTATVSWKRPVDDGGSEITGYHVE-RREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYE 14146
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F V A N G P S SD +
Sbjct: 14147 FRVSAENRAGIGPPSEASDSV 14167
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/199 (25%), Positives = 89/199 (44%), Gaps = 13/199 (6%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ ++ + ++ W P G S I GY + E + + ++ V R
Sbjct: 19488 PPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKS 19547
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL--SQDSCLPPAAPQQPHVIVV 153
T L+ G EY + A + AG LS P + L ++D P+ P +P ++
Sbjct: 19548 T------GLREGCEYEYRVYAENAAG---LSLPSETSPLIRAEDPVFLPSPPSKPKIVDS 19598
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
+ + ++W +G API Y+VE+ + D D W + + ++ I GL Y
Sbjct: 19599 GKTTITIAWVKPLFDGGAPITGYTVEYKKSD-DTDWKTSIQSLRGTEYTISGLTTGAEYV 19657
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V+++N G S S SD
Sbjct: 19658 FRVKSVNKVGASDPSDSSD 19676
Score = 63.9 bits (154), Expect = 7e-10
Identities = 55/205 (26%), Positives = 94/205 (45%), Gaps = 21/205 (10%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP LD+K N + W P G S I G+ + + ++H+ +
Sbjct: 8701 GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDA--------KMHTWRQPIET 8752
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV-TTLSQDSCLPPAAPQQPHVIVV 153
++ I L G EY+ + A ++ G G P + L+ D PP +P++
Sbjct: 8753 ERSKCDITGLLEGQEYKFRVIAKNKFGCG---PPVEIGPILAVDPLGPPTSPERLTYTER 8809
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIR---PDFDKKWTSIHERI-QMDSMVIKGLDPD 209
+ S + L WK S G +PIQ Y +E R PDF++ +++R+ S +++ LD
Sbjct: 8810 TKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFER----VNKRLCPTTSFLVENLDEH 8865
Query: 210 TNYQFAVRAMNSHGPSPRSWPSDII 234
Y+F V+A+N G S S P +++
Sbjct: 8866 QMYEFRVKAVNEIGESEPSLPLNVV 8890
Score = 63.5 bits (153), Expect = 9e-10
Identities = 54/204 (26%), Positives = 89/204 (43%), Gaps = 14/204 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ A+ + + W P G + I GY + +K +E + ++
Sbjct: 18406 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYIL-------EKRDKEGVRWTKCNKKT 18458
Query: 95 PTTEEV-IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
T + + L G Y +AA + AG G S P V + D+ PP P P V
Sbjct: 18459 LTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPS-VFYRACDALYPPGPPSNPKVTDT 18517
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMVIKGLDPDTN 211
S S V+L+W +G AP++ Y VE ++ +WT+ +Q + L +T
Sbjct: 18518 SRSSVSLAWSKPIYDGGAPVKGYVVE-VKEAAADEWTTCTPPTGLQGKQFTVTKLKENTE 18576
Query: 212 YQFAVRAMNSHG-PSPRSWPSDII 234
Y F + A+NS G P + P ++
Sbjct: 18577 YNFRICAINSEGVGEPATLPGSVV 18600
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/220 (25%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVP 89
KPG+ PP K+ T + W P + G I GY + +K + VP
Sbjct: 11898 KPGRPDPPEVTKVSKEEMT---VVWNPPEYDGGKSITGYFL-------EKKEKHSTRWVP 11947
Query: 90 LSRD-IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQP 148
+++ IP + +L P EY+ + A ++ G G S P +++D PP P
Sbjct: 11948 VNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSR-PVVAKDPIEPPGPPTNF 12006
Query: 149 HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-----DKKWTSIHERIQM--DSM 201
V+ + + L W +G API Y VE +RP D+ W + Q+
Sbjct: 12007 RVVDTTKHSITLGWGKPVYDGGAPIIGYVVE-MRPKIADASPDEGWKRCNAAAQLVRKEF 12065
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
+ LD + Y+F V A N G P+++ + P+E
Sbjct: 12066 TVTSLDENQEYEFRVCAQNQVGIGR---PAELKEAIKPKE 12102
Score = 62.8 bits (151), Expect = 2e-09
Identities = 50/191 (26%), Positives = 83/191 (43%), Gaps = 11/191 (5%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP ++ + + ++ W P GS I GY + E KSL L I
Sbjct: 20570 GPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY---FLEKRDKKSLG---WFKVLKETI 20623
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + + L ++Y+ + A + AG+G S P + D PP P + + +
Sbjct: 20624 RDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAA-DPIDPPGPPAKIRIADST 20682
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTNY 212
S + L W +G + + Y VE IR +++WT++ + ++ V+ L P NY
Sbjct: 20683 KSSITLGWSKPVYDGGSAVTGYVVE-IRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNY 20741
Query: 213 QFAVRAMNSHG 223
F V A+N G
Sbjct: 20742 YFRVSAVNCAG 20752
Score = 62.4 bits (150), Expect = 2e-09
Identities = 59/214 (27%), Positives = 86/214 (40%), Gaps = 25/214 (11%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSE------VGADKSLQEQL 85
G P + ++ +N + W P G SPI+GY + E V A+ +L
Sbjct: 12593 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTL---- 12648
Query: 86 HSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAP 145
+ +TE L G EY I A ++AG S P T +P P
Sbjct: 12649 --------VRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTAR----MPVDPP 12696
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK--KWTSIHERIQMDSMVI 203
+P VI V+ S V+L W +G + I Y VE + DK + + +I +
Sbjct: 12697 GKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTA 12756
Query: 204 KGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTL 237
GL+ YQF A + SP S PSD + L
Sbjct: 12757 TGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12790
Score = 62.0 bits (149), Expect = 3e-09
Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 19/220 (8%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G S + G+ GPP+ IK +++ ++ W P+ G S I Y + +
Sbjct: 9706 GTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI-------E 9758
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
K + V +S + I L G EY I A ++ G G T + S
Sbjct: 9759 KREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFS 9818
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
P AP +P V V+ + + ++W+ +G +P+ Y +E ++ K+W ++ R +
Sbjct: 9819 V--PGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLE-MKDTTSKRWKRVN-RDPI 9874
Query: 199 DSMV------IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+M + GL ++YQF V A+N+ G P S PSD
Sbjct: 9875 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD 9914
Score = 62.0 bits (149), Expect = 3e-09
Identities = 50/211 (23%), Positives = 96/211 (45%), Gaps = 10/211 (4%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYS 73
L S G++++ I + GPP I++ ++C + +I W P + G G +
Sbjct: 18970 LCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDG----GCQISNY 19025
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
V ++ H V S+ + T I L G+EY+ + A ++ GK S V
Sbjct: 19026 IVEKKETTSTTWHIV--SQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV-- 19081
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH 193
+++ PP P P V+ + S + ++W+ ++G + + Y +E+ + W+ +
Sbjct: 19082 VAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY-KERSSILWSKAN 19140
Query: 194 ERIQMDS-MVIKGLDPDTNYQFAVRAMNSHG 223
+ + D+ M + GLD Y++ V A N G
Sbjct: 19141 KILIADTQMKVSGLDEGLMYEYRVYAENIAG 19171
Score = 60.8 bits (146), Expect = 6e-09
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 20/221 (9%)
Query: 15 ASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYS 73
++ L AV ++ ++PG G P + +++ +QW P + G + I+GY +
Sbjct: 17991 SAPLDSKAVIVQYPFKEPGPPGTPF---VTSISKDQMLVQWHEPVNDGGTKIIGYHLEQK 18047
Query: 74 EVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT 133
E + L +L+ P I T+ L G EY ++A + G G+ S
Sbjct: 18048 E--KNSILWVKLNKTP----IQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF- 18100
Query: 134 LSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDF-DKKW-TS 191
+++D C PP P+ IV++ + V L WK A +G + I Y VE + D D +W +
Sbjct: 18101 VARDPCDPPGRPE---AIVITRNNVTLKWKKPAYDGGSKITGYIVE--KKDLPDGRWMKA 18155
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + GL D Y+F V A N+ G S PSD
Sbjct: 18156 SFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNF--SEPSD 18194
Score = 60.8 bits (146), Expect = 6e-09
Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 19/233 (8%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L L +++G + ++R I KPG G P++ K + ++ W+ P G + T
Sbjct: 20448 LKLRNAMGSASATIRVQILDKPGPPGGPIEFK--TVTAEKITLLWRPPADDGGAKI--TH 20503
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
+ E + + S L I TT ++I G EY + A ++ G G
Sbjct: 20504 YIVEKRETSRVVWSMVSEHLEECIITTTKII----KGNEYIFRVRAVNKYGIGEPLESDS 20559
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-- 188
V +++++ + P P P V ++ + + + W ++G + I Y +E DKK
Sbjct: 20560 V--VAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLE----KRDKKSL 20613
Query: 189 -WTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
W + E I+ + GL +++YQ+ V A+N+ G P S PS+ + P
Sbjct: 20614 GWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADP 20666
Score = 60.8 bits (146), Expect = 6e-09
Identities = 63/227 (27%), Positives = 98/227 (43%), Gaps = 19/227 (8%)
Query: 12 LLLASSLGPGAVSLRA-AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYT 69
L+L + G AV ++ I P PL+ + + + W+ P G + ILGY
Sbjct: 23710 LVLENKCGKKAVYIKVRVIGSPNSPEGPLEYD--DIQVRSVRVSWRPPADDGGADILGYI 23767
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSP 128
+ EV + + + T V+ LK EY ++A +Q G + L S
Sbjct: 23768 LERREV-------PKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSE 23820
Query: 129 RHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
VT + + PP P P V+ V+ S V+LSW +G + + Y +E DK
Sbjct: 23821 EPVTPKTPLN--PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDK 23878
Query: 188 KWTSIHERIQMDSMV--IKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
W H + Q+ + + + GL PD YQF + A N G S S S+
Sbjct: 23879 -WVR-HNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASE 23923
Score = 60.5 bits (145), Expect = 8e-09
Identities = 47/201 (23%), Positives = 92/201 (45%), Gaps = 7/201 (3%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
G P + ++ + ++ W+ P + G SP+ GY + + + + ++++ P+
Sbjct: 9821 GAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKR--WKRVNRDPIKAMT 9878
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ L G++Y+ + A + AG G S P T ++D PP P P V +
Sbjct: 9879 LGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPAT-ARDPIAPPGPPF-PKVTDWT 9936
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTNYQ 213
S L W P +G + + Y VE+ + + ++W ++ ++ +V+ GL Y+
Sbjct: 9937 KSSADLEWSPPLKDGGSKVTGYIVEY-KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYK 9995
Query: 214 FAVRAMNSHGPSPRSWPSDII 234
F VRA+N G +D+I
Sbjct: 9996 FRVRAVNIAGIGEPGEVTDVI 10016
Score = 60.1 bits (144), Expect = 1e-08
Identities = 52/211 (24%), Positives = 92/211 (43%), Gaps = 17/211 (8%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
GPPL++ + +N S+ W+ P + G + T + E+ S++ + D+
Sbjct: 6695 GPPLNVTITDVNRFGVSLTWEPPEYDGGAEI--TNYVIELRDKTSIRWDTAMTVRAEDLS 6752
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + D+ G EY + A ++ G G+ S+ ++ P P P + SD
Sbjct: 6753 AT---VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD----PIERPSPPVNLTSSD 6805
Query: 156 ---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTN 211
S V L W+P +G +PI Y +E D W + ++ + + + GL+
Sbjct: 6806 QTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKD-NWIRCNMKLVPELTYKVTGLEKGNK 6864
Query: 212 YQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
Y + V A N G S PS+I+ L ++A
Sbjct: 6865 YLYRVSAENKAGVSD---PSEILGPLTADDA 6892
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/197 (27%), Positives = 78/197 (39%), Gaps = 12/197 (6%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP + + + + W PR G S I Y V D + +L S
Sbjct: 7286 KPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVV--ERRATDSEVWHKLSSTVKDT 7343
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T+ L P EY +AA + G G +T Q PP P +
Sbjct: 7344 NFKATK-----LIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFD--PPGPPTRLEPSD 7396
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKGLDPDTN 211
++ V L+W +G +PI Y VE + PD D KW ++ D+ +KGL
Sbjct: 7397 ITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD-KWVRCNKMPVKDTTYRVKGLTNKKK 7455
Query: 212 YQFAVRAMNSHGPSPRS 228
Y+F V A N GP S
Sbjct: 7456 YRFRVLAENLAGPGKPS 7472
Score = 59.3 bits (142), Expect = 2e-08
Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 18/226 (7%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLS 91
K GPP IK+ ++ T+ +I W+ P G+P+ GY V + L P+S
Sbjct: 23334 KPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWL-------PVS 23386
Query: 92 RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVI 151
+ + L G EY +AA ++ G G + S S P P+ +
Sbjct: 23387 ESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRS--SIRIPGPPETLQIF 23444
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEF--IRPDFDKKWTSIHE-RIQMDSMVIKGLDP 208
VS + L+W P +G + + Y VE +R D +W +++ + M GL
Sbjct: 23445 DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRAD---RWVRVNKVPVTMTRYRSTGLTE 23501
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITD 254
Y+ V A+N+ G S PS I + P PR +TD
Sbjct: 23502 GLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPR-VTD 23546
Score = 59.3 bits (142), Expect = 2e-08
Identities = 67/216 (31%), Positives = 95/216 (43%), Gaps = 23/216 (10%)
Query: 31 KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEV--GADKSLQEQLHS 87
KP K P+ I+ AL + I WK P G S I Y V E GA+ L S
Sbjct: 24225 KPDKPTGPIVIE--ALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAIS 24282
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTT--LSQDSCLPPAAP 145
V R + TE G +RVS A + G +S P V++ + + P AP
Sbjct: 24283 VTTCRIVNLTENA------GYYFRVS--AQNTFG---ISDPLEVSSVVIIKSPFEKPGAP 24331
Query: 146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIK 204
+P + V+ ++WKP AS+G A I+ Y +E R KW S+ E I+ +K
Sbjct: 24332 GKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVK 24390
Query: 205 GLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPE 240
L Y+F V+ N G S W S+I + P+
Sbjct: 24391 NLIEGLEYEFRVKCENLGGES--EW-SEISEPITPK 24423
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/215 (25%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 19 GPGAVSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGA 77
GP VS + P G P + + + ++W P+ GSPILGY + EV +
Sbjct: 8389 GPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREVNS 8448
Query: 78 ------DKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+KSL L + + L G Y + A + AG G+ S P
Sbjct: 8449 THWSRVNKSLLNALKAN------------VDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8496
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
T + D PP P P V S + + L W+P A G I Y V+ ++
Sbjct: 8497 KT-AHDPISPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC 8554
Query: 192 IHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSP 226
+ I++ +K + +Y+ V A+N+ G P
Sbjct: 8555 TEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGP 8589
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/186 (25%), Positives = 80/186 (43%), Gaps = 11/186 (5%)
Query: 53 IQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRV 112
+ W P G PI Y + E ++ ++ V P T+ + DL G +Y
Sbjct: 10533 VTWNKPHDGGKPITNYILEKRE-----TMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 10587
Query: 113 SIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAP 172
++A ++ G G S P ++D P+ P P I + + V L+W+P +G +
Sbjct: 10588 RVSAENEIGIGDPSPPSK-PVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSK 10646
Query: 173 IQYYSVEFIRPDFDKKWTSIH---ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRS 228
I Y VE+ + D++W + E + GL Y+F V A+N+ G S P
Sbjct: 10647 ILGYIVEYQKVG-DEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 10705
Query: 229 WPSDII 234
P ++
Sbjct: 10706 VPEPVL 10711
Score = 58.9 bits (141), Expect = 2e-08
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 15/217 (6%)
Query: 12 LLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTV 70
L L + G AV + +R GP D+K+ + T+ + W P + GS + Y V
Sbjct: 12181 LTLVNPAGEKAVFVN--VRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIV 12238
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG-RLSSPR 129
E AD+ ++ ++ T + +L PG EY + A ++ G G P+
Sbjct: 12239 EKRE--ADRKTWS-----TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPK 12291
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFD-KK 188
V L+ D P P++ V ++ + L+W P +G A I Y + + +
Sbjct: 12292 PV--LASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADR 12349
Query: 189 WTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
WT + ++ S+V+ GL Y+F V A N+ G S
Sbjct: 12350 WTE-YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVS 12385
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/226 (26%), Positives = 95/226 (42%), Gaps = 20/226 (8%)
Query: 30 RKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSV 88
R PG G P+ + + S+ W P + G S + G+ V E + L +++++
Sbjct: 21258 RIPGPPGKPV---IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKE--RNSILWQKVNTS 21312
Query: 89 PLS-RDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
P+S R+ T L G +Y+ + A + AG S P T + P P
Sbjct: 21313 PISGREYRAT-----GLVEGLDYQFRVYAENSAGLSSPSDPSKFTL----AVSPVDPPGT 21363
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIH-ERIQMDSMVIKGL 206
P I V+ + L W P +G + I YS+E + +++W + + + GL
Sbjct: 21364 PDYIDVTRETITLKWNPPLRDGGSKIVGYSIE--KRQGNERWVRCNFTDVSECQYTVTGL 21421
Query: 207 DPDTNYQFAVRAMNSHGP-SPRSWPSDIIRTLCPEEAGSGRYGPRY 251
P Y+F + A N+ G SP S S II T +GP Y
Sbjct: 21422 SPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEY 21467
Score = 58.5 bits (140), Expect = 3e-08
Identities = 55/214 (25%), Positives = 96/214 (44%), Gaps = 13/214 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGAD 78
G S+ ++ + GPP + + + ++ WK P + GS I+ Y V E
Sbjct: 16126 GERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETS-- 16183
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDS 138
+L + ++ T + L G EY I A ++ G G V ++++
Sbjct: 16184 -----RLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPV--VAKNP 16236
Query: 139 CLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQM 198
+ P AP+ P V V+ + + W+ AS+G + I Y +E R +WT H+R+
Sbjct: 16237 FVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLE-KRDKEGIRWTRCHKRLIG 16295
Query: 199 D-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPS 231
+ + + GL + +Y+F V A N+ G S S PS
Sbjct: 16296 ELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPS 16329
Score = 58.5 bits (140), Expect = 3e-08
Identities = 54/236 (22%), Positives = 96/236 (40%), Gaps = 12/236 (5%)
Query: 2 DLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRH 60
D IR + +L S++G G S+ ++ + GPP +K+ + + W P
Sbjct: 18273 DCIRTDGGQYILKLSNVG-GTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQ 18331
Query: 61 PGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQA 120
G + + + +K +L +S ++ + L PG EY + A ++
Sbjct: 18332 DGGANISHYII------EKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKY 18385
Query: 121 GKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEF 180
G G VT + PP P P V ++ + ++W +G I+ Y +E
Sbjct: 18386 GIGEPLESGPVTACNPYK--PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILE- 18442
Query: 181 IRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIR 235
R +WT +++ D + + GL +Y+F V A N+ G S PS R
Sbjct: 18443 KRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 18498
Score = 58.2 bits (139), Expect = 4e-08
Identities = 59/212 (27%), Positives = 93/212 (43%), Gaps = 21/212 (9%)
Query: 36 GPPLDIKLGALNCTA--FSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
GPP + L+ T +I W+ P+ G SP++ Y V + D +S
Sbjct: 11108 GPPTG-PINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTW-------GVVSS 11159
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT-TLSQDSCLPPAAPQQPHVI 151
T+ I L+ G EY + A ++ G G P T T+++ PP+ P +P V
Sbjct: 11160 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVG---PPLDSTPTVAKHKFSPPSPPGKPVVT 11216
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDT 210
++++ +SW S+G +PI Y +E R + KW +++ D + GL
Sbjct: 11217 DITENAATVSWTLPKSDGGSPITGYYME--RREVTGKWVRVNKTPIADLKFRVTGLYEGN 11274
Query: 211 NYQFAVRAMNSHG---PSPRSWPSDIIRTLCP 239
Y+F V A N G PSP S P R + P
Sbjct: 11275 TYEFRVFAENLAGLSKPSPSSDPIKACRPIKP 11306
Score = 57.8 bits (138), Expect = 5e-08
Identities = 60/223 (26%), Positives = 94/223 (42%), Gaps = 19/223 (8%)
Query: 21 GAVSLRAAIRKPG-KVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGAD 78
G +S++ + KPG GP IK + A +++W P+ G S I Y + +
Sbjct: 13569 GTISIKV-VGKPGIPTGP---IKFDEVTAEAMTLKWAPPKDDGGSEITNYIL-------E 13617
Query: 79 KSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQD 137
K V + + T + L G EY ++A ++ G G L S V D
Sbjct: 13618 KRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFD 13677
Query: 138 SCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-I 196
P AP P+++ V V+L+W G +PI Y +EF + W ++ I
Sbjct: 13678 V---PDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEF-KERNSLLWKRANKTPI 13733
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+M + GL Y+F V A+N G S PS+ + L P
Sbjct: 13734 RMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDP 13776
Score = 56.2 bits (134), Expect = 1e-07
Identities = 53/193 (27%), Positives = 85/193 (44%), Gaps = 14/193 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG G P+ + L + + + +QW P GS ++GY + E + L +L+ P
Sbjct: 15844 PGPPGTPV-VTLSSRD--SMEVQWNEPISDGGSRVIGYHLERKE--RNSILWVKLNKTP- 15897
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
IP T+ L+ G EY ++A + G G+ S +++D C PP P+
Sbjct: 15898 ---IPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECY-VARDPCDPPGRPE---A 15950
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
I+V+ + V L WK +G + I Y VE + + I + GL D
Sbjct: 15951 IIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDH 16010
Query: 211 NYQFAVRAMNSHG 223
Y+F V A N+ G
Sbjct: 16011 RYEFRVIARNAAG 16023
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/195 (26%), Positives = 84/195 (43%), Gaps = 13/195 (6%)
Query: 33 GKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQ-EQLHSVPL 90
G GPP ++ + ++ WK P G S I GY V E KSL+ + P+
Sbjct: 14073 GPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE---KKSLRWVRAIKTPV 14129
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
S D+ + L+ G+ Y ++A ++AG G S + L +D+ PP P PHV
Sbjct: 14130 S-DLRCK---VTGLQEGSTYEFRVSAENRAGIGPPSEASD-SVLMKDAAYPPGPPSNPHV 14184
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW--TSIHERIQMDSMVIKGLDP 208
+ +L+W +G I Y VE + D+ W + +++ V+ L
Sbjct: 14185 TDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVG-DEAWIKDTTGTALRITQFVVPDLQT 14243
Query: 209 DTNYQFAVRAMNSHG 223
Y F + A+N G
Sbjct: 14244 KEKYNFRISAINDAG 14258
Score = 55.5 bits (132), Expect = 3e-07
Identities = 55/211 (26%), Positives = 87/211 (41%), Gaps = 16/211 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PG PP DI ++ A S+ W +P G S I Y V +V V
Sbjct: 12495 PGPPQPPFDIS--DIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDW-------VTA 12545
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR-LSSPRHVTTLSQDSCLPPAAPQQPH 149
+ T +G L PG EY + A ++ G L+SP+ V +Q P+ P+
Sbjct: 12546 LASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMV---AQFPFGVPSEPKNAR 12602
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDP 208
V V+ + ++W S+G +PI Y +E + W ++ ++ GL
Sbjct: 12603 VTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN-SLLWVKANDTLVRSTEYPCAGLVE 12661
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
Y F + A+N G SP S P++ + P
Sbjct: 12662 GLEYSFRIYALNKAGSSPPSKPTEYVTARMP 12692
Score = 53.9 bits (128), Expect = 7e-07
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 15/201 (7%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLH 86
A+ G PP + ++ + + + W P G S I+ Y V + + ++
Sbjct: 15151 AVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCN-- 15208
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQ--DSCLPPAA 144
+ + + L G EY I A + AG +S+P + + D+ P
Sbjct: 15209 ----KKTLTDLRYKVSGLTEGHEYEFRIMAENAAG---ISAPSPTSPFYKACDTVFKPGP 15261
Query: 145 PQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI--HERIQMDSMV 202
P P V+ S S ++++W +G + I Y VE P+ D +W + ++ S
Sbjct: 15262 PGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEED-EWQIVTPPAGLKATSYT 15320
Query: 203 IKGLDPDTNYQFAVRAMNSHG 223
I GL + Y+ + AMNS G
Sbjct: 15321 ITGLTENQEYKIRIYAMNSEG 15341
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/225 (25%), Positives = 96/225 (42%), Gaps = 17/225 (7%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GP L+++ + + ++ W +P GS I Y V E + +S ++
Sbjct: 14372 GPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREA------TRKSYSTATTKCH 14425
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T +V G L G EY + A ++ G G + S+ P+ P +++ ++
Sbjct: 14426 KCTYKVTG-LSEGCEYFFRVMAENEYGIGEPTETTEPVKASE----APSPPDSLNIMDIT 14480
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S V+L+W +G + I Y +E R D+ WT I ++ V++ L Y F
Sbjct: 14481 KSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQ-WTHI-TTVKGLECVVRNLTEGEEYTF 14538
Query: 215 AVRAMNSHGPS-PRSWPSDIIR--TLCPEEAGSGRYGPRYITDMG 256
V A+NS G S PR I++ T+ PE G Y I G
Sbjct: 14539 QVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 14583
Score = 52.8 bits (125), Expect = 2e-06
Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 11/200 (5%)
Query: 37 PPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
PP +++ + ++W +P + GSPI Y V +V K Q + +
Sbjct: 7589 PPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRR-KGWQT------VDTTVK 7641
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T+ + L G+ Y +AA + G+ + + L++D+ P P V+ V+
Sbjct: 7642 DTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIED-SVLAKDTFTTPGPPYALAVVDVTK 7700
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKGLDPDTNYQF 214
V L W+P ++G PIQ Y +E + +W + D + + + T QF
Sbjct: 7701 RHVDLKWEPPKNDGGRPIQRYVIE-KKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQF 7759
Query: 215 AVRAMNSHGPSPRSWPSDII 234
VRA N G S P++I+
Sbjct: 7760 QVRAENEAGVGHPSEPTEIL 7779
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 18/194 (9%)
Query: 52 SIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RDIPTTEEVIGDLKPGTE 109
S+ W P+ G SPI GY + + E + L ++ + P+ RD T L G E
Sbjct: 13696 SLTWTDPKKTGGSPITGYHLEFKE--RNSLLWKRANKTPIRMRDFKVT-----GLTEGLE 13748
Query: 110 YRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEG 169
Y + A + AG G+ S P ++ D PP +P VI ++ + V L W +G
Sbjct: 13749 YEFRVMAINLAGVGKPSLPSE-PVVALDPIDPPG---KPEVINITRNSVTLIWTEPKYDG 13804
Query: 170 SAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+ Y VE R K W H + + + L Y+F +RA N+ G S
Sbjct: 13805 GHKLTGYIVE-KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAI--S 13861
Query: 229 WPSDIIRT-LCPEE 241
PS+ T +C +E
Sbjct: 13862 APSESTETIICKDE 13875
Score = 52.0 bits (123), Expect = 3e-06
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 14/182 (7%)
Query: 46 LNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDL 104
++ A SI+W+ P H G S I+GY V E ++E + VP + +V G L
Sbjct: 22355 VSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKE--NKVPC---LECNYKVTG-L 22408
Query: 105 KPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKP 164
G EY+ A + AG + S ++Q+ P AP +P V V+ S V+L W
Sbjct: 22409 VEGLEYQFRTYALNAAGVSKASEASR-PIMAQN---PVDAPGRPEVTDVTRSTVSLIWSA 22464
Query: 165 GASEGSAPIQYYSVEF--IRPDFDKKWTSIHERIQMDS-MVIKGLDPDTNYQFAVRAMNS 221
A +G + + Y +E + D +W + I D+ + L Y+F V A N+
Sbjct: 22465 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNA 22524
Query: 222 HG 223
G
Sbjct: 22525 AG 22526
Score = 52.0 bits (123), Expect = 3e-06
Identities = 53/221 (23%), Positives = 85/221 (38%), Gaps = 23/221 (10%)
Query: 19 GPGA------VSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
GPG + R + P G P ++ G + IQW P G + I Y V
Sbjct: 22724 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHII---IQWTKPESDGGNEISNYLV- 22779
Query: 72 YSEVGADKSLQEQLHSVPLSRD--IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
DK ++ L +++D + T + L G +Y+ + A + AG S
Sbjct: 22780 ------DKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEAS 22833
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ + + S P P P V+ + ++L+W +G I Y +E D D +W
Sbjct: 22834 NFISCREPS-YTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTD-QW 22891
Query: 190 TSIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRS 228
+H I+ + L Y F V A+N G S S
Sbjct: 22892 YRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYS 22932
Score = 51.2 bits (121), Expect = 5e-06
Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 18/199 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+++ + ++ + + W+ P GSPI+ Y V K E+ ++ +
Sbjct: 13291 GPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVV-------QKRDAERKSWSTVTTEC 13343
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T + +L+ G Y + A ++ G G R SQ P V VS
Sbjct: 13344 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQT----PGPVVDLKVRSVS 13399
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQF 214
S ++ WK S+G + I Y V+F+ + KW + + + + K L Y F
Sbjct: 13400 KSSCSIGWKKPHSDGGSRIIGYVVDFLTE--ENKWQRVMKSLSLQYSA-KDLTEGKEYTF 13456
Query: 215 AVRAMNSHGPSPRSWPSDI 233
V A N +G PS+I
Sbjct: 13457 RVSAENENG---EGTPSEI 13472
Score = 51.2 bits (121), Expect = 5e-06
Identities = 50/188 (26%), Positives = 80/188 (42%), Gaps = 13/188 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP K+ + + W++P + G S ++GY + Y E L + + + ++
Sbjct: 19091 GPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKE--RSSILWSKANKILIA--- 19145
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
T+ + L G Y + A + AG G+ S ++D C PP QP V ++
Sbjct: 19146 -DTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVP-ARDPCDPPG---QPEVTNIT 19200
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI-HERIQMDSMVIKGLDPDTNYQ 213
V+L W +G A I Y VE R D +W + IQ + L D Y+
Sbjct: 19201 RKSVSLKWSKPHYDGGAKITGYIVE-RRELPDGRWLKCNYTNIQETYFEVTELTEDQRYE 19259
Query: 214 FAVRAMNS 221
F V A N+
Sbjct: 19260 FRVFARNA 19267
Score = 51.2 bits (121), Expect = 5e-06
Identities = 74/330 (22%), Positives = 123/330 (37%), Gaps = 27/330 (8%)
Query: 11 LLLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYT 69
+L L + G +V++ + KPG PL+I L S+ W P+ G + Y
Sbjct: 19364 VLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN--GLTAEKCSLSWGRPQEDGGADIDYY 19421
Query: 70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
+ +K L ++ T + L G EY + ++ G G
Sbjct: 19422 I------VEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESV 19475
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
+ L D P+ P + V+ + L W S+G + I Y +E R +W
Sbjct: 19476 AIKAL--DPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIE-RREKNSLRW 19532
Query: 190 TSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
++++ D V GL Y++ V A N+ G S S S +IR P S
Sbjct: 19533 VRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSK 19592
Query: 249 PRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
P+ + D I+ VKPL + VE KK ++ KT +
Sbjct: 19593 PKIV-------------DSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQS 19639
Query: 309 IPPTSASLP-VTTVAPQPIPIQRKGKNGVA 337
+ T ++ +TT A ++ K G +
Sbjct: 19640 LRGTEYTISGLTTGAEYVFRVKSVNKVGAS 19669
Score = 50.4 bits (119), Expect = 8e-06
Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 10/112 (8%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K PP++ + C + + W+ PRH GS ILGY V Y +VG D+ + H+
Sbjct: 10615 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVG-DEEWRRANHT---PE 10670
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV--TTLSQDSCLPP 142
P T+ + L+ G Y+ + A + AG+ S P HV L +D PP
Sbjct: 10671 SCPETKYKVTGLRDGQTYKFRVLAVNAAGE---SDPAHVPEPVLVKDRLEPP 10719
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/207 (24%), Positives = 84/207 (40%), Gaps = 15/207 (7%)
Query: 32 PGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPL 90
PGKV P I+ + ++ W P + G +PI Y + +K +L +
Sbjct: 21555 PGKVVGP--IRFTNITGEKMTLWWDAPLNDGCAPITHYII-------EKRETSRLAWALI 21605
Query: 91 SRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHV 150
L G EY+ ++A ++ G GR V ++Q P AP P
Sbjct: 21606 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPV--VAQIQYTVPDAPGIPEP 21663
Query: 151 IVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDP 208
++ + + L+W S+G + IQ Y +E R +W + + I + GL
Sbjct: 21664 SNITGNSITLTWARPESDGGSEIQQYILE-RREKKSTRWVKVISKRPISETRFKVTGLTE 21722
Query: 209 DTNYQFAVRAMNSHGPSPRSWPSDIIR 235
Y+F V A N+ G P S S +I+
Sbjct: 21723 GNEYEFHVMAENAAGVGPASGISRLIK 21749
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/244 (21%), Positives = 98/244 (40%), Gaps = 15/244 (6%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
L + ++ G AVS+ + PG G ++ CT + W +P+ G + + +
Sbjct: 22623 LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCT---LAWSLPQEDGGAEITHYI 22679
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
++ +L+ V + + PT V+ L EY + A ++ G G
Sbjct: 22680 ------VERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEP 22733
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWT 190
+ ++++S P+ P P + + + W S+G I Y V+ R +WT
Sbjct: 22734 I--VARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDK-REKKSLRWT 22790
Query: 191 SIHER--IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYG 248
+++ + + + L +YQF V A+N+ G S S S+ I P
Sbjct: 22791 RVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSA 22850
Query: 249 PRYI 252
PR +
Sbjct: 22851 PRVV 22854
Score = 49.3 bits (116), Expect = 2e-05
Identities = 56/219 (25%), Positives = 86/219 (39%), Gaps = 21/219 (9%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G S +R PP+++K+ + + SI W+ P GS I Y V +K
Sbjct: 16523 GTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIV-------EK 16575
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ + + I L+ G Y + A ++ G G + + D
Sbjct: 16576 REATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG-------LPAQTADPI 16628
Query: 140 LPPAAPQQPHVIVVSD---SEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERI 196
PQ P I V D + V+LSW +G + I Y VE ++ +KW+ R+
Sbjct: 16629 KVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVE-MQAKHSEKWSEC-ARV 16686
Query: 197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
+ VI L Y F V A+N G S PRS I+
Sbjct: 16687 KSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIV 16725
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/216 (25%), Positives = 88/216 (40%), Gaps = 15/216 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMP-RHPGSPILGYTVFYSEVGADK 79
G+ S +R GPP D+K+ + T+ ++ W P GS I Y V +K
Sbjct: 15441 GSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIV-------EK 15493
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ ++ + T + L+ G Y + A ++ G G + T S +
Sbjct: 15494 RESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAE----TAESVKAS 15549
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
P P + ++ V+ + V+LSW+ +G + I Y VE D KW + +++
Sbjct: 15550 ERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSD-KWATC-ATVKVT 15607
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS-PRSWPSDII 234
I GL Y F V A N G S PR +I
Sbjct: 15608 EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 15643
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/192 (22%), Positives = 81/192 (42%), Gaps = 13/192 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLS-RD 93
GPP +++ + + ++ W P G S I+GY V +K + + + + R
Sbjct: 17323 GPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIV-------EKRDRSGIRWIKCNKRR 17375
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVV 153
I + L EY ++A + AG G SP V + D P P H++
Sbjct: 17376 ITDLRLRVTGLTEDHEYEFRVSAENAAGVGE-PSPATVYYKACDPVFKPGPPTNAHIVDT 17434
Query: 154 SDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER--IQMDSMVIKGLDPDTN 211
+ + + L+W +G + I Y VE + D +++W + + +++ I L
Sbjct: 17435 TKNSITLAWGKPIYDGGSEILGYVVEICKAD-EEEWQIVTPQTGLRVTRFEISKLTEHQE 17493
Query: 212 YQFAVRAMNSHG 223
Y+ V A+N G
Sbjct: 17494 YKIRVCALNKVG 17505
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/206 (22%), Positives = 87/206 (42%), Gaps = 14/206 (6%)
Query: 21 GAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADK 79
G+ S ++ GPP ++ + + + + W+ P G+ + Y + DK
Sbjct: 17605 GSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVI-------DK 17657
Query: 80 SLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSC 139
+ +S T + +L G Y + A ++ G G T + +
Sbjct: 17658 RESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVE----TVDAVKAA 17713
Query: 140 LPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD 199
PP+ P + + VS + +L W+ +G + + Y VE ++P +KW+ + E ++
Sbjct: 17714 EPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVE-MQPKGTEKWSIVAES-KVC 17771
Query: 200 SMVIKGLDPDTNYQFAVRAMNSHGPS 225
+ V+ GL YQF V+A N G S
Sbjct: 17772 NAVVTGLSSGQEYQFRVKAYNEKGKS 17797
Score = 48.1 bits (113), Expect = 4e-05
Identities = 59/239 (24%), Positives = 93/239 (38%), Gaps = 28/239 (11%)
Query: 16 SSLGPGAVSLRAAIRKPGKV---------GPPLD-IKLGALNCTAFSIQWKMPRHPGS-P 64
S GP ++ R + + G V GPP IK ++ + W P + G P
Sbjct: 14634 SDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14693
Query: 65 ILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGR 124
I Y V + + V L+ + T L G EY+ + A ++ G G
Sbjct: 14694 ISNYVVEMRQT-------DSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGP 14746
Query: 125 LSSPRHVTTLSQDSCLP---PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFI 181
+T+ + P P P P V V+ + +SW S+G +PI Y VE
Sbjct: 14747 -----GITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVE-R 14800
Query: 182 RPDFDKKWTSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ W ++ + + ++ GL Y+F V A N G S S PS+ + L P
Sbjct: 14801 KERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDP 14859
Score = 47.8 bits (112), Expect = 5e-05
Identities = 47/200 (23%), Positives = 77/200 (38%), Gaps = 13/200 (6%)
Query: 32 PGKVGPP-LDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVP 89
PG VG P L L +C + W P G SPI Y + +K ++ P
Sbjct: 10119 PGPVGTPFLAHNLTNESC---KLTWFSPEDDGGSPITNYVI-------EKRESDRRAWTP 10168
Query: 90 LSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPH 149
++ + + L G Y IAA + G G + + +P P+
Sbjct: 10169 VTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPER-PEDLE 10227
Query: 150 VIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPD 209
V V+ + V L+W P +G + I Y +E +K ++ + +KGL
Sbjct: 10228 VKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEG 10287
Query: 210 TNYQFAVRAMNSHGPSPRSW 229
Y++ V A+N G S+
Sbjct: 10288 DTYEYRVSAVNIVGQGKPSF 10307
Score = 47.4 bits (111), Expect = 7e-05
Identities = 52/207 (25%), Positives = 87/207 (42%), Gaps = 27/207 (13%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP++ + T+ +W+ P G S I+ YT L+++ + P S I
Sbjct: 8306 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYT-----------LEKKDKTKPDSEWI 8354
Query: 95 PTTEEV------IGDLKPGTEYRVSIAAYSQAGKGR--LSSPRHVTTLSQDSCLPPAAPQ 146
T + + L G EY + A ++ G G +S P +++D PP AP
Sbjct: 8355 VVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKP----LVAKDPFGPPDAPD 8410
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV-IKG 205
+P V V+ + + + W GS + Y+ + R W+ +++ + + G
Sbjct: 8411 KPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEK--REVNSTHWSRVNKSLLNALKANVDG 8468
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSD 232
L Y F V A N+ GP S PSD
Sbjct: 8469 LLEGLTYVFRVCAENAAGPGKFSPPSD 8495
Score = 47.4 bits (111), Expect = 7e-05
Identities = 49/189 (25%), Positives = 78/189 (41%), Gaps = 13/189 (6%)
Query: 50 AFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGT 108
A ++ W +P+ G SPI GY + EV +++ P++ + + L G
Sbjct: 11222 AATVSWTLPKSDGGSPITGYYMERREVTGK---WVRVNKTPIA----DLKFRVTGLYEGN 11274
Query: 109 EYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASE 168
Y + A + AG + SP + PP P P + S L W S+
Sbjct: 11275 TYEFRVFAENLAGLSK-PSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSD 11333
Query: 169 GSAPIQYYSVEFIRPDFDKKWTSIH--ERIQMDSMVIKGLDPDTNYQFAVRAMNSHGP-S 225
G +PI Y VE +P +W I+ E I+ + + GL Y+F ++A N G
Sbjct: 11334 GGSPILGYVVECQKPG-TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 11392
Query: 226 PRSWPSDII 234
PR +I
Sbjct: 11393 PRELAESVI 11401
Score = 47.4 bits (111), Expect = 7e-05
Identities = 51/219 (23%), Positives = 90/219 (41%), Gaps = 14/219 (6%)
Query: 13 LLASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVF 71
+L +S G+ S ++ + GPP +++ + S+ W P G + + V
Sbjct: 17200 ILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYV- 17258
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
+K +L ++ ++ T + L G EY I A ++ G G V
Sbjct: 17259 -----VEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPV 17313
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTS 191
L ++ + P P+ V ++ + + W S+G + I Y VE R +W
Sbjct: 17314 --LMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVE-KRDRSGIRWIK 17370
Query: 192 IHERIQMD-SMVIKGLDPDTNYQFAVRAMNSHG---PSP 226
++R D + + GL D Y+F V A N+ G PSP
Sbjct: 17371 CNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSP 17409
Score = 47.0 bits (110), Expect = 9e-05
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 26/264 (9%)
Query: 22 AVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKS 80
A SL ++ GPP +I + + + + W +P + G+P+ Y + +K
Sbjct: 19768 AASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHI-------EKR 19820
Query: 81 LQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCL 140
+ V ++ + + +L+ G Y ++ ++ G G + + +++
Sbjct: 19821 EASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE---- 19876
Query: 141 PPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P+ P++ V +S V+L+W +G + I +Y VE + K W +
Sbjct: 19877 KPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKG-QKNWVKC-AVAKSTH 19934
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS-PRS--WPSDIIRTLCPEEAGSGRYGPRYITDMGA 257
V+ GL ++ Y F V A N G S PR P I L P E + P + + A
Sbjct: 19935 HVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNF-PSHTVYVRA 19993
Query: 258 GEDDEGFEDDLDLDISFEEVKPLP 281
G +L +DI KPLP
Sbjct: 19994 G-------SNLKVDIPISG-KPLP 20009
Score = 46.2 bits (108), Expect = 2e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 17/214 (7%)
Query: 14 LASSLGPGAVSLRAAIRKPGKVGPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVF 71
L +S G +L + K GPP +K+ + + ++ W P++ G S I Y V
Sbjct: 15725 LTNSAGEAIETLNVIVLD--KPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIV- 15781
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHV 131
E + Q+ S ++R TT + LK G EY+ IAA ++ GK +
Sbjct: 15782 --EKRDTSTTTWQIVSATVAR---TTIKACR-LKTGCEYQFRIAAENRYGKSTYLNSE-- 15833
Query: 132 TTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWT 190
T++Q P P P V + S + + W S+G + + Y +E R + + W
Sbjct: 15834 PTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLE--RKERNSILWV 15891
Query: 191 SIHER-IQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
+++ I GL+ Y+F V A N G
Sbjct: 15892 KLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVG 15925
Score = 46.2 bits (108), Expect = 2e-04
Identities = 49/192 (25%), Positives = 76/192 (39%), Gaps = 11/192 (5%)
Query: 34 KVGPPLD-IKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSR 92
K GPP+ ++ ++ I W+ P + G G + V + H V S
Sbjct: 17907 KPGPPVGPVRFDEVSADFVVISWEPPAYTG----GCQISNYIVEKRDTTTTTWHMV--SA 17960
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
+ T I LK GTEY+ I A ++ GK + V + Q P P P V
Sbjct: 17961 TVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAV--IVQYPFKEPGPPGTPFVTS 18018
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHER-IQMDSMVIKGLDPDTN 211
+S ++ + W ++G I Y +E + W +++ IQ GLD
Sbjct: 18019 ISKDQMLVQWHEPVNDGGTKIIGYHLE-QKEKNSILWVKLNKTPIQDTKFKTTGLDEGLE 18077
Query: 212 YQFAVRAMNSHG 223
Y+F V A N G
Sbjct: 18078 YEFKVSAENIVG 18089
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP I++ ++ ++ W P + G S + GY V + +E+ +V ++
Sbjct: 20671 GPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQ-----GEEEEWTTVSTKGEV 20725
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
TTE V+ +LKPG Y ++A + AG+G
Sbjct: 20726 RTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20754
Score = 45.8 bits (107), Expect = 2e-04
Identities = 32/118 (27%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 26 RAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQ 84
R A++ GP +D+K+ +++ ++ SI WK P GS I+GY V + + + Q
Sbjct: 13378 RDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDF--LTEENKWQRV 13435
Query: 85 LHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPP 142
+ S+ L DL G EY ++A ++ G+G +P +T +++D + P
Sbjct: 13436 MKSLSLQYSAK-------DLTEGKEYTFRVSAENENGEG---TPSEITVVARDDVVAP 13483
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + +SW P ++G + + +Y VE D K W+++ ++ S + L P Y
Sbjct: 12213 VTKTSCHVSWAPPENDGGSQVTHYIVEKREAD-RKTWSTVTPEVKKTSFHVTNLVPGNEY 12271
Query: 213 QFAVRAMNSHGPS-PRSWPSDII 234
F V A+N +GP P P ++
Sbjct: 12272 YFRVTAVNEYGPGVPTDVPKPVL 12294
Score = 43.9 bits (102), Expect = 8e-04
Identities = 60/208 (28%), Positives = 84/208 (40%), Gaps = 30/208 (14%)
Query: 36 GPPLD-IKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRD 93
GPP+ + + I WK P G S I Y + EVG D + P++
Sbjct: 10416 GPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWM-------PVTSA 10468
Query: 94 IPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL-SQDSCLPPAAPQQPHVIV 152
T + L G +Y I A + G +S P ++ ++D P AP QP V
Sbjct: 10469 SAKTTCKVSKLLEGKDYIFRIHAENLYG---ISDPLVSDSMKAKDRFRVPDAPDQPIVTE 10525
Query: 153 VSDSEVALSW-KPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM--VIKGLDPD 209
V+ ++W KP +G PI Y +E R K+W R+ D + K PD
Sbjct: 10526 VTKDSALVTWNKP--HDGGKPITNYILE-KRETMSKRWA----RVTKDPIHPYTKFRVPD 10578
Query: 210 ----TNYQFAVRAMNSHG---PSPRSWP 230
Y+F V A N G PSP S P
Sbjct: 10579 LLEGCQYEFRVSAENEIGIGDPSPPSKP 10606
Score = 43.9 bits (102), Expect = 8e-04
Identities = 56/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)
Query: 38 PLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPT 96
P+++ + + + ++ W+ P G+ I Y V +K + ++ +
Sbjct: 18705 PVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIV-------EKRETTRKAYATITNNCTK 18757
Query: 97 TEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDS 156
T I +L+ G Y + A ++ G G + +S+ PP P + ++ V+ +
Sbjct: 18758 TTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE----PPLPPGRVTLVDVTRN 18813
Query: 157 EVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAV 216
+ W+ S+G + I Y VE ++ +KW++ +++ I GL Y F V
Sbjct: 18814 TATIKWEKPESDGGSKITGYVVE-MQTKGSEKWSTC-TQVKTLEATISGLTAGEEYVFRV 18871
Query: 217 RAMNSHGPS-PRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFE 275
A+N G S PR +I E P + ++ A E L +D+ F+
Sbjct: 18872 AAVNEKGRSDPRQLGVPVIAR--DIEIKPSVELPFHTFNVKARE-------QLKIDVPFK 18922
Query: 276 EVKPLPATKGGNKKFLVESKKMSISNPKTISRL 308
+ + L E+ ++++S+ KT++ L
Sbjct: 18923 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSL 18955
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 14/119 (11%)
Query: 28 AIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHP-GSPILGYTVFYSEVGADKSLQEQLH 86
A++ PP + L ++ T+ S+ W+ P H GS +LGY V G +K
Sbjct: 17709 AVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEK------- 17761
Query: 87 SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR--HVTTLSQDSCLPPA 143
+ + V+ L G EY+ + AY++ GK S PR V +++D + P+
Sbjct: 17762 -WSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGK---SDPRVLGVPVIAKDLTIQPS 17816
Score = 43.5 bits (101), Expect = 0.001
Identities = 51/217 (23%), Positives = 97/217 (44%), Gaps = 16/217 (7%)
Query: 29 IRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHS 87
I +PG V P+++ +++ + + W P+ G + I Y V E G + QL
Sbjct: 22241 IGRPGPVTGPIEVS--SVSAESCVLSWGEPKDGGGTEITNYIVEKRESG---TTAWQL-- 22293
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQ 146
++ + T+ + L EY +++ ++ G +S P +++ +PP+AP
Sbjct: 22294 --VNSSVKRTQIKVTHLTKYMEYSFRVSSENRFG---VSKPLESAPIIAEHPFVPPSAPT 22348
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMD-SMVIKG 205
+P V VS + +++ W+ +G + I Y VE + W ++ ++ + + G
Sbjct: 22349 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVE-KKERNTILWVKENKVPCLECNYKVTG 22407
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEA 242
L YQF A+N+ G S S S I P +A
Sbjct: 22408 LVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDA 22444
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/103 (30%), Positives = 42/103 (40%), Gaps = 7/103 (6%)
Query: 124 RLSSPRHVTTLSQDSCLPPAAPQQP-HVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIR 182
R++ P V TL PP+ P+ P + V LSW G I YS+E R
Sbjct: 21147 RIAVPITVITLG-----PPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEK-R 21200
Query: 183 PDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
W + + + + L D YQF VRA N +G S
Sbjct: 21201 ETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 21243
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/217 (24%), Positives = 81/217 (37%), Gaps = 28/217 (12%)
Query: 27 AAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSP----ILG--YTVFYSEVGADKS 80
+A+ K G VG PLD + IQ+ +P PG P I G T+ ++ +D
Sbjct: 21630 SAVNKFG-VGRPLDS-----DPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGG 21683
Query: 81 LQEQLH-------------SVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSS 127
+ Q + V R I T + L G EY + A + AG G S
Sbjct: 21684 SEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASG 21743
Query: 128 PRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDK 187
+ ++ PP P V S + V+L W +G I Y +E + D
Sbjct: 21744 ISRLIKC-REPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLG- 21801
Query: 188 KWTSIH-ERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
W ++ E + L Y+F V A+N G
Sbjct: 21802 DWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21838
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P+ P + V+ + LSW P +G A I +Y V+ R WT++ +Q+
Sbjct: 15058 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQK-RETSRLAWTNVASEVQVTK 15116
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ + L Y F V A+N +G
Sbjct: 15117 LKVTKLLKGNEYIFRVMAVNKYG 15139
Score = 42.0 bits (97), Expect = 0.003
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 14/199 (7%)
Query: 37 PPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95
P +K ++ + ++ W P + G I Y V + + V +S +
Sbjct: 16829 PKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIV------QKRDTTTTVWDV-VSATVA 16881
Query: 96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSD 155
T + LK GTEY+ I A ++ G+ + ++Q P P P +S
Sbjct: 16882 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPI--VAQYPYKEPGPPGTPFATAISK 16939
Query: 156 SEVALSWKPGASEGSAPIQYYSVEFIRPDFDK-KWTSIHERIQMDSMV-IKGLDPDTNYQ 213
+ + W + G +P+ Y +E R + + WT +++ I D+ + L+ Y+
Sbjct: 16940 DSMVIQWHEPVNNGGSPVIGYHLE--RKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYE 16997
Query: 214 FAVRAMNSHGPSPRSWPSD 232
F V A N G S S+
Sbjct: 16998 FRVYAENIVGVGKASKNSE 17016
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/101 (28%), Positives = 42/101 (41%), Gaps = 1/101 (0%)
Query: 142 PAAPQQPHVI-VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI + + +SWKP A +G + I Y VE +W + I + +
Sbjct: 24226 PDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTT 24285
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEE 241
I L + Y F V A N+ G S S ++ P E
Sbjct: 24286 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFE 24326
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 23/190 (12%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP+ ++ + T ++W+ P + G I+GY V VG ++ S + I
Sbjct: 8507 GPPIP-RVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNE------WSRCTEKMI 8559
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
+ + +++ G +Y++ ++A + AG+G + VT A PQ+P +
Sbjct: 8560 KVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV---------AEPQEPPAV--- 8607
Query: 155 DSEVALSWKPGAS-EGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQ 213
E+ +S K G ++ +V RP K WT + D +VI + +
Sbjct: 8608 --ELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELI 8665
Query: 214 FAVRAMNSHG 223
HG
Sbjct: 8666 IKDALRKDHG 8675
Score = 40.0 bits (92), Expect = 0.011
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 1/98 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP++ ++ V L+W+P +G +P+ Y VE R K WT + + +
Sbjct: 6991 PSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVE-KREVSRKTWTKVMDFVTDLEF 7049
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCP 239
+ L Y F V A N GP ++ + + P
Sbjct: 7050 TVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTP 7087
Score = 40.0 bits (92), Expect = 0.011
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P P + VS + L+W P +G +PI+ Y +E R WT + E IQ
Sbjct: 13976 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILE-KRETSRLLWTVVSEDIQSCRH 14034
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
V L Y F V A+N +G
Sbjct: 14035 VATKLIQGNEYIFRVSAVNHYG 14056
Score = 39.3 bits (90), Expect = 0.019
Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 8/140 (5%)
Query: 92 RDIPTTEEVIGDLKP-GTEYRVSIAAYSQAGKGRLS--SPRHVTTLSQDSCL--PPAAPQ 146
RD PT + D+ P G++ + AA+ G L+ +P T+S + P P+
Sbjct: 10760 RDAPTKARI--DVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPR 10817
Query: 147 QPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGL 206
V + L+WK +G + I Y VE R +W+ + + S K L
Sbjct: 10818 DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER-RDVASAQWSPLSATSKKKSHFAKHL 10876
Query: 207 DPDTNYQFAVRAMNSHGPSP 226
+ Y F V A N +G P
Sbjct: 10877 NEGNQYLFRVAAENQYGRGP 10896
Score = 39.3 bits (90), Expect = 0.019
Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 9/112 (8%)
Query: 15 ASSLGPGA-VSLRAAIRKP-GKVGPPLDIKLGALNCTAFSIQWKMPRHPGS-PILGYTVF 71
A+ +GP + +S R+P GPP +K+ + T S++W P G I+GY +
Sbjct: 21735 AAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIE 21794
Query: 72 YSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKG 123
+ H V + T V DL+ G EY+ ++A + AGKG
Sbjct: 21795 MCKADLG-----DWHKVNAEACVKTRYTVT-DLQAGEEYKFRVSAINGAGKG 21840
Score = 38.9 bits (89), Expect = 0.025
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P+AP + V V LSW+P +G A I Y VE R K + +I +
Sbjct: 18702 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE-KRETTRKAYATITNNCTKTTF 18760
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
I+ L +Y F V A N +G
Sbjct: 18761 RIENLQEGCSYYFRVLASNEYG 18782
Score = 38.9 bits (89), Expect = 0.025
Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 14/158 (8%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ + L+W +G A I +Y VE R W + S V+ L + Y
Sbjct: 22655 VTQEKCTLAWSLPQEDGGAEITHYIVER-RETSRLNWVIVEGECPTLSYVVTRLIKNNEY 22713
Query: 213 QFAVRAMNSHGPSPRSWPSDIIRTL---------CPEEAGSGRYGPRYITDMGAGEDDEG 263
F VRA+N +GP I+ PEE G+G+ +I + +G
Sbjct: 22714 IFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK---EHIIIQWTKPESDG 22770
Query: 264 FEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISN 301
+ + + E K L T+ NK ++V ++ +++
Sbjct: 22771 GNEISNYLVDKREKKSLRWTR-VNKDYVVYDTRLKVTS 22807
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/100 (33%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
T+ D P P+ V VS V L+W AS+G + I Y VE + +W +
Sbjct: 24616 TVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRV 24674
Query: 193 HERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSD 232
+ + VI L T+YQF V A N G S S PS+
Sbjct: 24675 GQARETRYTVI-NLFGKTSYQFRVIAENKFGLSKPSEPSE 24713
Score = 37.7 bits (86), Expect = 0.055
Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 2/85 (2%)
Query: 142 PAAPQQPHVIV-VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDS 200
P P P VI +++ V L W+P +G + + Y + R WT + +
Sbjct: 20073 PGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY-ILLKRETSTAVWTEVSATVARTM 20131
Query: 201 MVIKGLDPDTNYQFAVRAMNSHGPS 225
M + L YQF ++A N G S
Sbjct: 20132 MKVMKLTTGEEYQFRIKAENRFGIS 20156
Score = 37.0 bits (84), Expect = 0.094
Identities = 36/171 (21%), Positives = 69/171 (40%), Gaps = 17/171 (9%)
Query: 36 GPPLDIKLGALNCTAFSIQWKMPRHPG-SPILGYTVFYSEVGADKSLQEQLHSVPLSRDI 94
GPP + ++ + ++ W P + G +PI+GY V AD S E + +
Sbjct: 12001 GPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQL 12060
Query: 95 PTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVS 154
E + L EY + A +Q G GR + +++ P + P + + +
Sbjct: 12061 VRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAE-------LKEAIKPKEILEPPEIDLDA 12113
Query: 155 DSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKG 205
+ + G PI+ +++ RP W ++ +D++V KG
Sbjct: 12114 SMRKLVIVRAG-----CPIRLFAIVRGRPAPKVTW----RKVGIDNVVRKG 12155
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDS 200
P P V +S ++W+P +G +PI Y V+ + D ++K W+++ S
Sbjct: 13290 PGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ--KRDAERKSWSTVTTECSKTS 13347
Query: 201 MVIKGLDPDTNYQFAVRAMNSHG 223
+ L+ +Y F V A N +G
Sbjct: 13348 FRVANLEEGKSYFFRVFAENEYG 13370
Score = 36.6 bits (83), Expect = 0.12
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
PAA Q+ V VS V L W P +G +PI Y +E R + W+ + + S
Sbjct: 20869 PAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE-KRDATKRTWSVVSHKCSSTSF 20927
Query: 202 VIKGLDPDTNYQFAVRAMNSHG 223
+ L T + F V A N G
Sbjct: 20928 KLIDLSEKTPFFFRVLAENEIG 20949
Score = 34.3 bits (77), Expect = 0.61
Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 2/88 (2%)
Query: 153 VSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNY 212
V+ L W +G A I +Y VE R + W I E+ + L Y
Sbjct: 21963 VTRGSATLMWDAPLLDGGARIHHYVVEK-REASRRSWQVISEKCTRQIFKVNDLAEGVPY 22021
Query: 213 QFAVRAMNSHG-PSPRSWPSDIIRTLCP 239
F V A+N +G P P I+ T P
Sbjct: 22022 YFRVSAVNEYGVGEPYEMPEPIVATEQP 22049
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/142 (28%), Positives = 57/142 (40%), Gaps = 16/142 (11%)
Query: 89 PLS-RDIPTTEEV----IGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPA 143
PLS + I TT E I + K G + R I ++ GK V + P
Sbjct: 6542 PLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDV-------PG 6594
Query: 144 APQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK-WTSIHERIQMDSMV 202
+ V D EV+L+W+ ++G + I Y VE R D +K W +R +
Sbjct: 6595 PVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVE--RRDIKRKTWVLATDRAESCEFT 6652
Query: 203 IKGLDP-DTNYQFAVRAMNSHG 223
+ GL Y F V A N G
Sbjct: 6653 VTGLQKGGVEYLFRVSARNRVG 6674
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 11/197 (5%)
Query: 34 KVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQ-LHSVPLSR 92
+V P + ++L T ++ P H + + G + E ++++ E+ ++ +++
Sbjct: 8895 EVPPTIKLRLSVRGDT-IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 8953
Query: 93 DIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSP-RHVTTLSQDSCLPPAAPQQPHVI 151
+ + E +L R Y+ RL S R+V D P+ P+ V
Sbjct: 8954 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDR---PSPPRNLAVT 9010
Query: 152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKK---WTSIHERIQMDSMVIKGLDP 208
+ L+W G + I +Y ++ + D +K W + I L P
Sbjct: 9011 DIKAESCYLTWDAPLDNGGSEITHYVID--KRDASRKKAEWEEVTNTAVEKRYGIWKLIP 9068
Query: 209 DTNYQFAVRAMNSHGPS 225
+ Y+F VRA+N +G S
Sbjct: 9069 NGQYEFRVRAVNKYGIS 9085
Score = 32.0 bits (71), Expect = 3.0
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)
Query: 88 VPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQ 147
V L +D+P E I + + I+A + +G + S+ +V P Q
Sbjct: 11458 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR-------PGPCQN 11510
Query: 148 PHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLD 207
V V+ +SW+ G + I + VE+ +P+ K W+ + + ++ L
Sbjct: 11511 LKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPN-QKGWSIVASDV-TKRLIKANLL 11568
Query: 208 PDTNYQFAVRAMNSHGPSP 226
+ Y F V A N G P
Sbjct: 11569 ANNEYYFRVCAENKVGVGP 11587
Score = 31.2 bits (69), Expect = 5.1
Identities = 21/93 (22%), Positives = 33/93 (35%), Gaps = 1/93 (1%)
Query: 142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSM 201
P + ++ VS + W P +G IQ Y +E W++ +
Sbjct: 11800 PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETK-RMVWSTYSATVLTPGT 11858
Query: 202 VIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDII 234
+ L Y F VRA N G P + +I
Sbjct: 11859 TVTRLIEGNEYIFRVRAENKIGTGPPTESKPVI 11891
Score = 30.4 bits (67), Expect = 8.8
Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 8/124 (6%)
Query: 111 RVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGS 170
+ +I A +Q+GK + T L + P P V VS V ++W+ +G
Sbjct: 23017 KYTIEAENQSGK------KSATVLVKVYDTPGPCPSVK-VKEVSRDSVTITWEIPTIDGG 23069
Query: 171 APIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWP 230
AP+ Y VE R + + ++ + I GL T Y F V N +G
Sbjct: 23070 APVNNYIVE-KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCET 23128
Query: 231 SDII 234
SD +
Sbjct: 23129 SDAV 23132
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 79.7 bits (195), Expect = 1e-14
Identities = 65/243 (26%), Positives = 116/243 (47%), Gaps = 30/243 (12%)
Query: 37 PPLDIKLGALNCTAFSIQWKMP---RHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRD 93
PP D+K ++ TA + W+ P H G+ ++GY+V Y +G++ ++++ +P
Sbjct: 608 PPQDVKCVSVRSTAILVSWRPPPPETHNGA-LVGYSVRYRPLGSEDPEPKEVNGIP---- 662
Query: 94 IPTTEEVIGD-LKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV 152
PTT +++ + L+ T+YR++ A+++ G G SSP V T D +P A P++
Sbjct: 663 -PTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRT---DEDVPSAPPRKVEAEA 718
Query: 153 VSDSEVALSWK---PGASEGSAPIQYYSVEFIRPDFDKKW--TSIHERIQMDS--MVIKG 205
++ + + + W+ PG G I+ Y V ++R + + I + + D+ MVI
Sbjct: 719 LNATAIRVLWRSPAPGRQHGQ--IRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITN 776
Query: 206 LDPDTNYQFAVRAMNSHGPSPRSWPSDIIR--------TLCPEEAGSGRYGPRYITDMGA 257
L P+T Y V A G RS P ++ TL ++ G R+ G
Sbjct: 777 LQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGT 836
Query: 258 GED 260
ED
Sbjct: 837 AED 839
Score = 65.9 bits (159), Expect = 2e-10
Identities = 58/214 (27%), Positives = 89/214 (41%), Gaps = 16/214 (7%)
Query: 16 SSLGPGAVSLRAAIRKPGKV--GPPLDIKLGALNCTAFSIQWKMPRHPG---SPILGYTV 70
+ +GPG S +R V PP ++ ALN TA + W+ P PG I GY V
Sbjct: 687 TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPA-PGRQHGQIRGYQV 745
Query: 71 FYSEV-GADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPR 129
Y + GA+ ++ V L+ E VI +L+P T Y +++AAY+ G G S P+
Sbjct: 746 HYVRMEGAEARGPPRIKDVMLA---DAQEMVITNLQPETAYSITVAAYTMKGDGARSKPK 802
Query: 130 HVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW 189
V T P + QQ + + W+P A + Y ++F R D
Sbjct: 803 VVVTKGAVLGRPTLSVQQ-----TPEGSLLARWEPPAGTAEDQVLGYRLQFGRED-STPL 856
Query: 190 TSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
++ D G+ Y F + A + G
Sbjct: 857 ATLEFPPSEDRYTASGVHKGATYVFRLAARSRGG 890
Score = 64.7 bits (156), Expect = 4e-10
Identities = 60/230 (26%), Positives = 102/230 (44%), Gaps = 20/230 (8%)
Query: 12 LLLASSLGPGAVSLRAAIR-KPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTV 70
+L +S+G G +S ++ + G G P++++ A + T+ ++ W PR I+ Y +
Sbjct: 488 VLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES--IIKYEL 545
Query: 71 FYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRH 130
+ E + + PTT V+ DLKP TEY +AA S G G +
Sbjct: 546 LFREGDHGREVGRTFD--------PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVR 597
Query: 131 VTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASE-GSAPIQYYSVEFIRP--DFDK 187
TL P A PQ + V + + +SW+P E + + YSV + RP D
Sbjct: 598 QRTLQSK---PSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRY-RPLGSEDP 653
Query: 188 KWTSIHERIQMDSMV-IKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRT 236
+ ++ + + ++ L+ T Y+ A GP P S P ++RT
Sbjct: 654 EPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPV-VVRT 702
Score = 64.3 bits (155), Expect = 5e-10
Identities = 57/211 (27%), Positives = 89/211 (42%), Gaps = 18/211 (8%)
Query: 16 SSLGPGAVSLRAAIRKPGKVGP---PLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFY 72
+S+G G S + + + G+ P P +++ L+ T +QW+ P P I GY V+Y
Sbjct: 393 NSIGQGPPS-ESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY 451
Query: 73 SEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVT 132
+ Q H+V S + TT +G L Y V + A++ G G LS P V
Sbjct: 452 TMEPEHPVGNWQKHNVDDS--LLTT---VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVK 506
Query: 133 TLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSI 192
T P P S++ + LSW P E I Y + F D ++
Sbjct: 507 TQQG----VPGQPMNLRAEARSETSITLSWSPPRQES---IIKYELLFREGDHGREVGRT 559
Query: 193 HERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
+ S V++ L P+T Y F + A + G
Sbjct: 560 FD--PTTSYVVEDLKPNTEYAFRLAARSPQG 588
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/186 (24%), Positives = 71/186 (38%), Gaps = 14/186 (7%)
Query: 49 TAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGT 108
T+ +I W P+ Y + Y D Q + DI TT IG L P +
Sbjct: 333 TSITITWDSGNP--DPVSYYVIEYKSKSQDGPYQ-------IKEDITTTRYSIGGLSPNS 383
Query: 109 EYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASE 168
EY + ++A + G+G S T Q P +AP+ ++S + + + W+ E
Sbjct: 384 EYEIWVSAVNSIGQGPPSESVVTRTGEQ---APASAPRNVQARMLSATTMIVQWEEPV-E 439
Query: 169 GSAPIQYYSVEF-IRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPR 227
+ I+ Y V + + P+ H + L D Y V A S G P
Sbjct: 440 PNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPL 499
Query: 228 SWPSDI 233
S P +
Sbjct: 500 SDPIQV 505
Score = 38.9 bits (89), Expect = 0.025
Identities = 49/185 (26%), Positives = 75/185 (40%), Gaps = 19/185 (10%)
Query: 54 QWKMPRHPGSP-ILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRV 112
+W+ P +LGY + + G + S P S D T V G Y
Sbjct: 829 RWEPPAGTAEDQVLGYRL---QFGREDSTPLATLEFPPSEDRYTASGV----HKGATYVF 881
Query: 113 SIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIV-VSDSEVALSWKPGA-SEGS 170
+AA S+ G G ++ V ++ +D+ P PQ S V L W P +E +
Sbjct: 882 RLAARSRGGLGEEAA--EVLSIPEDT--PRGHPQILEAAGNASAGTVLLRWLPPVPAERN 937
Query: 171 APIQYYSVEF-----IRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPS 225
I Y+V + P + + + E +++ ++GL PDT Y VRA GP
Sbjct: 938 GAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPG 997
Query: 226 PRSWP 230
P S P
Sbjct: 998 PFSPP 1002
Score = 38.5 bits (88), Expect = 0.032
Identities = 44/165 (26%), Positives = 67/165 (40%), Gaps = 24/165 (14%)
Query: 57 MPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIG--DLKPGTEYRVSI 114
+P I+ YTV E GA +E +P + + P E + LKP T Y + +
Sbjct: 932 VPAERNGAIVKYTVAVREAGALGPARET--ELPAAAE-PGAENALTLQGLKPDTAYDLQV 988
Query: 115 AAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWK-PGASEGSAP- 172
A+++ G G S P T +D +P+ V ++ + V LSW+ P P
Sbjct: 989 RAHTRRGPGPFSPPVRYRTFLRDQ----VSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPY 1044
Query: 173 -IQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAV 216
IQY + D D + T +I L P T Y F +
Sbjct: 1045 KIQYNGLTL---DVDGRTT---------KKLITHLKPHTFYNFVL 1077
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,956,437
Number of Sequences: 37866
Number of extensions: 2113949
Number of successful extensions: 9448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 5450
Number of HSP's gapped (non-prelim): 2992
length of query: 1009
length of database: 18,247,518
effective HSP length: 112
effective length of query: 897
effective length of database: 14,006,526
effective search space: 12563853822
effective search space used: 12563853822
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.